                         SEQUENCE LISTING

<110>  Fox Chase Cancer Center
       Katz, Richard A
       Skalka, Anna  M
 
<120>  ASSAY FOR IDENTIFYING AGENTS THAT MODULATE EPIGENETIC SILENCING, 
       AND AGENTS IDENTIFIED THEREBY

<130>  46598-0005-WO-00

<150>  US 61/125,932
<151>  2008-04-30

<160>  863   

<170>  PatentIn version 3.5

<210>  1
<211>  2091
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (64)..(1512)

<400>  1
gagcggagcc gcgggcggga gggcggacgg accgactgac ggtagggacg ggaggcgagc       60

aag atg gcg cag acg cag ggc acc cgg agg aaa gtc tgt tac tac tac        108
    Met Ala Gln Thr Gln Gly Thr Arg Arg Lys Val Cys Tyr Tyr Tyr           
    1               5                   10                  15            

gac ggg gat gtt gga aat tac tat tat gga caa ggc cac cca atg aag        156
Asp Gly Asp Val Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro Met Lys           
                20                  25                  30                

cct cac cga atc cgc atg act cat aat ttg ctg ctc aac tat ggt ctc        204
Pro His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr Gly Leu           
            35                  40                  45                    

tac cga aaa atg gaa atc tat cgc cct cac aaa gcc aat gct gag gag        252
Tyr Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Asn Ala Glu Glu           
        50                  55                  60                        

atg acc aag tac cac agc gat gac tac att aaa ttc ttg cgc tcc atc        300
Met Thr Lys Tyr His Ser Asp Asp Tyr Ile Lys Phe Leu Arg Ser Ile           
    65                  70                  75                            

cgt cca gat aac atg tcg gag tac agc aag cag atg cag aga ttc aac        348
Arg Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met Gln Arg Phe Asn           
80                  85                  90                  95            

gtt ggt gag gac tgt cca gta ttc gat ggc ctg ttt gag ttc tgt cag        396
Val Gly Glu Asp Cys Pro Val Phe Asp Gly Leu Phe Glu Phe Cys Gln           
                100                 105                 110               

ttg tct act ggt ggt tct gtg gca agt gct gtg aaa ctt aat aag cag        444
Leu Ser Thr Gly Gly Ser Val Ala Ser Ala Val Lys Leu Asn Lys Gln           
            115                 120                 125                   

cag acg gac atc gct gtg aat tgg gct ggg ggc ctg cac cat gca aag        492
Gln Thr Asp Ile Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys           
        130                 135                 140                       

aag tcc gag gca tct ggc ttc tgt tac gtc aat gat atc gtc ttg gcc        540
Lys Ser Glu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala           
    145                 150                 155                           

atc ctg gaa ctg cta aag tat cac cag agg gtg ctg tac att gac att        588
Ile Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile           
160                 165                 170                 175           

gat att cac cat ggt gac ggc gtg gaa gag gcc ttc tac acc acg gac        636
Asp Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp           
                180                 185                 190               

cgg gtc atg act gtg tcc ttt cat aag tat gga gag tac ttc cca gga        684
Arg Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly           
            195                 200                 205                   

act ggg gac cta cgg gat atc ggg gct ggc aaa ggc aag tat tat gct        732
Thr Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala           
        210                 215                 220                       

gtt aac tac ccg ctc cga gac ggg att gat gac gag tcc tat gag gcc        780
Val Asn Tyr Pro Leu Arg Asp Gly Ile Asp Asp Glu Ser Tyr Glu Ala           
    225                 230                 235                           

att ttc aag ccg gtc atg tcc aaa gta atg gag atg ttc cag cct agt        828
Ile Phe Lys Pro Val Met Ser Lys Val Met Glu Met Phe Gln Pro Ser           
240                 245                 250                 255           

gcg gtg gtc tta cag tgt ggc tca gac tcc cta tct ggg gat cgg tta        876
Ala Val Val Leu Gln Cys Gly Ser Asp Ser Leu Ser Gly Asp Arg Leu           
                260                 265                 270               

ggt tgc ttc aat cta act atc aaa gga cac gcc aag tgt gtg gaa ttt        924
Gly Cys Phe Asn Leu Thr Ile Lys Gly His Ala Lys Cys Val Glu Phe           
            275                 280                 285                   

gtc aag agc ttt aac ctg cct atg ctg atg ctg gga ggc ggt ggt tac        972
Val Lys Ser Phe Asn Leu Pro Met Leu Met Leu Gly Gly Gly Gly Tyr           
        290                 295                 300                       

acc att cgt aac gtt gcc cgg tgc tgg aca tat gag aca gct gtg gcc       1020
Thr Ile Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala           
    305                 310                 315                           

ctg gat acg gag atc cct aat gag ctt cca tac aat gac tac ttt gaa       1068
Leu Asp Thr Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu           
320                 325                 330                 335           

tac ttt gga cca gat ttc aag ctc cac atc agt cct tcc aat atg act       1116
Tyr Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr           
                340                 345                 350               

aac cag aac acg aat gag tac ctg gag aag atc aaa cag cga ctg ttt       1164
Asn Gln Asn Thr Asn Glu Tyr Leu Glu Lys Ile Lys Gln Arg Leu Phe           
            355                 360                 365                   

gag aac ctt aga atg ctg ccg cac gca cct ggg gtc caa atg cag gcg       1212
Glu Asn Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala           
        370                 375                 380                       

att cct gag gac gcc atc cct gag gag agt ggc gat gag gac gaa gac       1260
Ile Pro Glu Asp Ala Ile Pro Glu Glu Ser Gly Asp Glu Asp Glu Asp           
    385                 390                 395                           

gac cct gac aag cgc atc tcg atc tgc tcc tct gac aaa cga att gcc       1308
Asp Pro Asp Lys Arg Ile Ser Ile Cys Ser Ser Asp Lys Arg Ile Ala           
400                 405                 410                 415           

tgt gag gaa gag ttc tcc gat tct gaa gag gag gga gag ggg ggc cgc       1356
Cys Glu Glu Glu Phe Ser Asp Ser Glu Glu Glu Gly Glu Gly Gly Arg           
                420                 425                 430               

aag aac tct tcc aac ttc aaa aaa gcc aag aga gtc aaa aca gag gat       1404
Lys Asn Ser Ser Asn Phe Lys Lys Ala Lys Arg Val Lys Thr Glu Asp           
            435                 440                 445                   

gaa aaa gag aaa gac cca gag gag aag aaa gaa gtc acc gaa gag gag       1452
Glu Lys Glu Lys Asp Pro Glu Glu Lys Lys Glu Val Thr Glu Glu Glu           
        450                 455                 460                       

aaa acc aag gag gag aag cca gaa gcc aaa ggg gtc aag gag gag gtc       1500
Lys Thr Lys Glu Glu Lys Pro Glu Ala Lys Gly Val Lys Glu Glu Val           
    465                 470                 475                           

aag ttg gcc tga atggacctct ccagctctgg cttcctgctg agtccctcac           1552
Lys Leu Ala                                                               
480                                                                       

gtttcttccc caacccctca gattttatat tttctatttc tctgtgtatt tatataaaaa     1612

tttattaaat ataaatatcc ccagggacag aaaccaaggc cccgagctca gggcagctgt     1672

gctgggtgag ctcttccagg agccaccttg ccacccattc ttcccgttct taactttgaa     1732

ccataaaggg tgccaggtct gggtgaaagg gatactttta tgcaaccata agacaaactc     1792

ctgaaatgcc aagtgcctgc ttagtagctt tggaaaggtg cccttattga acattctaga     1852

aggggtggct gggtcttcaa ggatctcctg tttttttcag gctcctaaag taacatcagc     1912

catttttaga ttggttctgt tttcgtacct tcccactggc ctcaagtgag ccaagaaaca     1972

ctgcctgccc tctgtctgtc ttctcctaat tctgcaggtg gaggttgcta gtctagtttc     2032

ctttttgaga tactattttc atttttgtga gcctctttgt aataaaatgg tacatttct      2091


<210>  2
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gln Thr Gln Gly Thr Arg Arg Lys Val Cys Tyr Tyr Tyr Asp 
1               5                   10                  15      


Gly Asp Val Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro Met Lys Pro 
            20                  25                  30          


His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr Gly Leu Tyr 
        35                  40                  45              


Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Asn Ala Glu Glu Met 
    50                  55                  60                  


Thr Lys Tyr His Ser Asp Asp Tyr Ile Lys Phe Leu Arg Ser Ile Arg 
65                  70                  75                  80  


Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met Gln Arg Phe Asn Val 
                85                  90                  95      


Gly Glu Asp Cys Pro Val Phe Asp Gly Leu Phe Glu Phe Cys Gln Leu 
            100                 105                 110         


Ser Thr Gly Gly Ser Val Ala Ser Ala Val Lys Leu Asn Lys Gln Gln 
        115                 120                 125             


Thr Asp Ile Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys Lys 
    130                 135                 140                 


Ser Glu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala Ile 
145                 150                 155                 160 


Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile Asp 
                165                 170                 175     


Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp Arg 
            180                 185                 190         


Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly Thr 
        195                 200                 205             


Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala Val 
    210                 215                 220                 


Asn Tyr Pro Leu Arg Asp Gly Ile Asp Asp Glu Ser Tyr Glu Ala Ile 
225                 230                 235                 240 


Phe Lys Pro Val Met Ser Lys Val Met Glu Met Phe Gln Pro Ser Ala 
                245                 250                 255     


Val Val Leu Gln Cys Gly Ser Asp Ser Leu Ser Gly Asp Arg Leu Gly 
            260                 265                 270         


Cys Phe Asn Leu Thr Ile Lys Gly His Ala Lys Cys Val Glu Phe Val 
        275                 280                 285             


Lys Ser Phe Asn Leu Pro Met Leu Met Leu Gly Gly Gly Gly Tyr Thr 
    290                 295                 300                 


Ile Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala Leu 
305                 310                 315                 320 


Asp Thr Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu Tyr 
                325                 330                 335     


Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr Asn 
            340                 345                 350         


Gln Asn Thr Asn Glu Tyr Leu Glu Lys Ile Lys Gln Arg Leu Phe Glu 
        355                 360                 365             


Asn Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala Ile 
    370                 375                 380                 


Pro Glu Asp Ala Ile Pro Glu Glu Ser Gly Asp Glu Asp Glu Asp Asp 
385                 390                 395                 400 


Pro Asp Lys Arg Ile Ser Ile Cys Ser Ser Asp Lys Arg Ile Ala Cys 
                405                 410                 415     


Glu Glu Glu Phe Ser Asp Ser Glu Glu Glu Gly Glu Gly Gly Arg Lys 
            420                 425                 430         


Asn Ser Ser Asn Phe Lys Lys Ala Lys Arg Val Lys Thr Glu Asp Glu 
        435                 440                 445             


Lys Glu Lys Asp Pro Glu Glu Lys Lys Glu Val Thr Glu Glu Glu Lys 
    450                 455                 460                 


Thr Lys Glu Glu Lys Pro Glu Ala Lys Gly Val Lys Glu Glu Val Lys 
465                 470                 475                 480 


Leu Ala 
        


<210>  3
<211>  2632
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (208)..(2430)

<400>  3
acgacaatat ggcggcgctt agttgcatga aggcggaaac tctgtgactt ccggtccgta       60

gtggggcctg cggtgggagt gggaaggaag gcggagggaa ccatgcgagg ttctgagaat      120

tgcggcgagg gtcgcctcga gagacggttt ctgagcagga attctgaaat ccccaccact      180

tcctccctcc gggggatttg atcccct atg gcc acc gct aac agc atc atc gtg      234
                              Met Ala Thr Ala Asn Ser Ile Ile Val         
                              1               5                           

ctg gat gat gat gac gaa gat gaa gca gct gct cag cca ggg ccc tcc        282
Leu Asp Asp Asp Asp Glu Asp Glu Ala Ala Ala Gln Pro Gly Pro Ser           
10                  15                  20                  25            

cac cca ctc ccc aat gcg gcc tca cct ggg gca gaa gcc cct agc tcc        330
His Pro Leu Pro Asn Ala Ala Ser Pro Gly Ala Glu Ala Pro Ser Ser           
                30                  35                  40                

tct gag cct cat ggg gcc aga gga agc agt agt tcg ggc ggc aag aaa        378
Ser Glu Pro His Gly Ala Arg Gly Ser Ser Ser Ser Gly Gly Lys Lys           
            45                  50                  55                    

tgc tac aag ctg gag aat gag aag ctg ttc gaa gag ttc ctt gaa ctt        426
Cys Tyr Lys Leu Glu Asn Glu Lys Leu Phe Glu Glu Phe Leu Glu Leu           
        60                  65                  70                        

tgt aag atg cag aca gca gac cac cct gag gtg gtc cca ttc ctc tat        474
Cys Lys Met Gln Thr Ala Asp His Pro Glu Val Val Pro Phe Leu Tyr           
    75                  80                  85                            

aac cgg cag caa cgt gcc cac tct ctg ttt ttg gcc tcg gcg gag ttc        522
Asn Arg Gln Gln Arg Ala His Ser Leu Phe Leu Ala Ser Ala Glu Phe           
90                  95                  100                 105           

tgc aac atc ctc tct agg gtc ctg tct cgg gcc cgg agc cgg cca gcc        570
Cys Asn Ile Leu Ser Arg Val Leu Ser Arg Ala Arg Ser Arg Pro Ala           
                110                 115                 120               

aag ctc tat gtc tac atc aat gag ctc tgc act gtt ctc aag gcc cac        618
Lys Leu Tyr Val Tyr Ile Asn Glu Leu Cys Thr Val Leu Lys Ala His           
            125                 130                 135                   

tca gcc aaa aag aag ctg aac ttg gcc cct gcc gcc acc acc tcc aat        666
Ser Ala Lys Lys Lys Leu Asn Leu Ala Pro Ala Ala Thr Thr Ser Asn           
        140                 145                 150                       

gag ccc tct ggg aat aac cct ccc aca cac ctc tcc ttg gac ccc aca        714
Glu Pro Ser Gly Asn Asn Pro Pro Thr His Leu Ser Leu Asp Pro Thr           
    155                 160                 165                           

aat gct gaa aac act gcc tct cag tct cca agg acc cgt ggt tcc cgg        762
Asn Ala Glu Asn Thr Ala Ser Gln Ser Pro Arg Thr Arg Gly Ser Arg           
170                 175                 180                 185           

cgg cag atc cag cgt ttg gag cag ctg ctg gcg ctc tat gtg gca gag        810
Arg Gln Ile Gln Arg Leu Glu Gln Leu Leu Ala Leu Tyr Val Ala Glu           
                190                 195                 200               

atc cgg cgg ctg cag gaa aag gag ttg gat ctc tca gaa ttg gat gac        858
Ile Arg Arg Leu Gln Glu Lys Glu Leu Asp Leu Ser Glu Leu Asp Asp           
            205                 210                 215                   

cca gac tcc gca tac ctg cag gag gca cgg ttg aag cgt aag ctg atc        906
Pro Asp Ser Ala Tyr Leu Gln Glu Ala Arg Leu Lys Arg Lys Leu Ile           
        220                 225                 230                       

cgc ctc ttt ggg cga cta tgt gag ctg aaa gac tgc tct tca ctg acc        954
Arg Leu Phe Gly Arg Leu Cys Glu Leu Lys Asp Cys Ser Ser Leu Thr           
    235                 240                 245                           

ggc cgt gtc ata gag cag cgc atc ccc tac cgt ggc acc cgc tac cca       1002
Gly Arg Val Ile Glu Gln Arg Ile Pro Tyr Arg Gly Thr Arg Tyr Pro           
250                 255                 260                 265           

gag gtt aac agg cgc att gag cgg ctc atc aac aag cca ggg cct gat       1050
Glu Val Asn Arg Arg Ile Glu Arg Leu Ile Asn Lys Pro Gly Pro Asp           
                270                 275                 280               

acc ttc cct gac tat ggg gat gtg ctt cgg gct gta gag aag gca gct       1098
Thr Phe Pro Asp Tyr Gly Asp Val Leu Arg Ala Val Glu Lys Ala Ala           
            285                 290                 295                   

gcc cga cac agc ctt ggc ctc ccc cga cag cag ctc cag ctc atg gct       1146
Ala Arg His Ser Leu Gly Leu Pro Arg Gln Gln Leu Gln Leu Met Ala           
        300                 305                 310                       

cag gat gcc ttc cga gat gtg ggc atc agg tta cag gag cga cgt cac       1194
Gln Asp Ala Phe Arg Asp Val Gly Ile Arg Leu Gln Glu Arg Arg His           
    315                 320                 325                           

ctc gat ctc atc tac aac ttt ggc tgc cac ctc aca gat gac tat agg       1242
Leu Asp Leu Ile Tyr Asn Phe Gly Cys His Leu Thr Asp Asp Tyr Arg           
330                 335                 340                 345           

cca ggc gtt gac cct gca cta tca gat cct gtg ttg gcc cgg cgc ctt       1290
Pro Gly Val Asp Pro Ala Leu Ser Asp Pro Val Leu Ala Arg Arg Leu           
                350                 355                 360               

cgg gaa aac cgg agt ttg gcc atg agt cgg ctg gat gag gtc atc tcc       1338
Arg Glu Asn Arg Ser Leu Ala Met Ser Arg Leu Asp Glu Val Ile Ser           
            365                 370                 375                   

aaa tat gca atg ttg caa gac aaa agt gag gag ggc gag aga aaa aag       1386
Lys Tyr Ala Met Leu Gln Asp Lys Ser Glu Glu Gly Glu Arg Lys Lys           
        380                 385                 390                       

aga aga gct cgg ctc caa ggc acc tct tcc cac tct gca gac acc ccc       1434
Arg Arg Ala Arg Leu Gln Gly Thr Ser Ser His Ser Ala Asp Thr Pro           
    395                 400                 405                           

gaa gcc tcc ttg gat tct ggt gag ggc cct agt gga atg gca tcc cag       1482
Glu Ala Ser Leu Asp Ser Gly Glu Gly Pro Ser Gly Met Ala Ser Gln           
410                 415                 420                 425           

ggg tgc cct tct gcc tcc aga gct gag aca gat gac gaa gac gat gag       1530
Gly Cys Pro Ser Ala Ser Arg Ala Glu Thr Asp Asp Glu Asp Asp Glu           
                430                 435                 440               

gag agt gat gag gaa gag gag gag gag gag gaa gaa gaa gag gag gag       1578
Glu Ser Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu           
            445                 450                 455                   

gcc aca gat tct gaa gag gag gag gat ctg gaa cag atg cag gag ggt       1626
Ala Thr Asp Ser Glu Glu Glu Glu Asp Leu Glu Gln Met Gln Glu Gly           
        460                 465                 470                       

cag gag gat gat gaa gag gag gac gaa gag gaa gaa gca gca gca ggt       1674
Gln Glu Asp Asp Glu Glu Glu Asp Glu Glu Glu Glu Ala Ala Ala Gly           
    475                 480                 485                           

aaa gat gga gac aag agc ccc atg tcc tca cta cag atc tcc aat gaa       1722
Lys Asp Gly Asp Lys Ser Pro Met Ser Ser Leu Gln Ile Ser Asn Glu           
490                 495                 500                 505           

aag aac ctg gaa cct ggc aaa cag atc agc aga tct tca ggg gag cag       1770
Lys Asn Leu Glu Pro Gly Lys Gln Ile Ser Arg Ser Ser Gly Glu Gln           
                510                 515                 520               

caa aac aaa gga cgc ata gtg tca cca tcg tta ctg tca gaa gaa ccc       1818
Gln Asn Lys Gly Arg Ile Val Ser Pro Ser Leu Leu Ser Glu Glu Pro           
            525                 530                 535                   

ctg gcc ccc tcc agc ata gat gct gaa agc aat gga gaa cag cct gag       1866
Leu Ala Pro Ser Ser Ile Asp Ala Glu Ser Asn Gly Glu Gln Pro Glu           
        540                 545                 550                       

gag ctg acc ctg gag gaa gaa agc cct gtg tct cag ctc ttt gag cta       1914
Glu Leu Thr Leu Glu Glu Glu Ser Pro Val Ser Gln Leu Phe Glu Leu           
    555                 560                 565                           

gag att gaa gct ttg ccc ctg gat acc cct tcc tct gtg gag acg gac       1962
Glu Ile Glu Ala Leu Pro Leu Asp Thr Pro Ser Ser Val Glu Thr Asp           
570                 575                 580                 585           

att tcc tct tcc agg aag caa tca gag gag ccc ttc acc act gtc tta       2010
Ile Ser Ser Ser Arg Lys Gln Ser Glu Glu Pro Phe Thr Thr Val Leu           
                590                 595                 600               

gag aat gga gca ggc atg gtc tct tct act tcc ttc aat gga ggc gtc       2058
Glu Asn Gly Ala Gly Met Val Ser Ser Thr Ser Phe Asn Gly Gly Val           
            605                 610                 615                   

tct cct cac aac tgg gga gat tct ggt ccc ccc tgc aaa aaa tct cgg       2106
Ser Pro His Asn Trp Gly Asp Ser Gly Pro Pro Cys Lys Lys Ser Arg           
        620                 625                 630                       

aag gag aag aag caa aca gga tca ggg cca tta gga aac agc tat gtg       2154
Lys Glu Lys Lys Gln Thr Gly Ser Gly Pro Leu Gly Asn Ser Tyr Val           
    635                 640                 645                           

gaa agg caa agg tca gtg cat gag aag aat ggg aaa aag ata tgt acc       2202
Glu Arg Gln Arg Ser Val His Glu Lys Asn Gly Lys Lys Ile Cys Thr           
650                 655                 660                 665           

ctg ccc agc cca cct tcc ccc ttg gct tcc ttg gcc cca gtt gct gat       2250
Leu Pro Ser Pro Pro Ser Pro Leu Ala Ser Leu Ala Pro Val Ala Asp           
                670                 675                 680               

tcc tcc acg agg gtg gac tct ccc agc cat ggc ctg gtg acc agc tcc       2298
Ser Ser Thr Arg Val Asp Ser Pro Ser His Gly Leu Val Thr Ser Ser           
            685                 690                 695                   

ctc tgc atc cct tct cca gcc cgg ctg tcc caa acc ccc cat tca cag       2346
Leu Cys Ile Pro Ser Pro Ala Arg Leu Ser Gln Thr Pro His Ser Gln           
        700                 705                 710                       

cct cct cgg cct ggt act tgc aag aca agt gtg gcc aca caa tgc gat       2394
Pro Pro Arg Pro Gly Thr Cys Lys Thr Ser Val Ala Thr Gln Cys Asp           
    715                 720                 725                           

cca gaa gag atc atc gtg ctc tca gac tct gat tag ctgcctcccc            2440
Pro Glu Glu Ile Ile Val Leu Ser Asp Ser Asp                               
730                 735                 740                               

ttctccctgc ctccagaatg ttctgggata acatttggag gaaggtggga agcagatgac     2500

tgaggaaggg atggactaag ctaatcccct tttggtggtg tttctttaaa aaaaaaaaaa     2560

agcttaagtt ttacacagaa acattaataa acaataaagt tcttttctta ctgtaaaaaa     2620

aaaaaaaaaa aa                                                         2632


<210>  4
<211>  740
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Thr Ala Asn Ser Ile Ile Val Leu Asp Asp Asp Asp Glu Asp 
1               5                   10                  15      


Glu Ala Ala Ala Gln Pro Gly Pro Ser His Pro Leu Pro Asn Ala Ala 
            20                  25                  30          


Ser Pro Gly Ala Glu Ala Pro Ser Ser Ser Glu Pro His Gly Ala Arg 
        35                  40                  45              


Gly Ser Ser Ser Ser Gly Gly Lys Lys Cys Tyr Lys Leu Glu Asn Glu 
    50                  55                  60                  


Lys Leu Phe Glu Glu Phe Leu Glu Leu Cys Lys Met Gln Thr Ala Asp 
65                  70                  75                  80  


His Pro Glu Val Val Pro Phe Leu Tyr Asn Arg Gln Gln Arg Ala His 
                85                  90                  95      


Ser Leu Phe Leu Ala Ser Ala Glu Phe Cys Asn Ile Leu Ser Arg Val 
            100                 105                 110         


Leu Ser Arg Ala Arg Ser Arg Pro Ala Lys Leu Tyr Val Tyr Ile Asn 
        115                 120                 125             


Glu Leu Cys Thr Val Leu Lys Ala His Ser Ala Lys Lys Lys Leu Asn 
    130                 135                 140                 


Leu Ala Pro Ala Ala Thr Thr Ser Asn Glu Pro Ser Gly Asn Asn Pro 
145                 150                 155                 160 


Pro Thr His Leu Ser Leu Asp Pro Thr Asn Ala Glu Asn Thr Ala Ser 
                165                 170                 175     


Gln Ser Pro Arg Thr Arg Gly Ser Arg Arg Gln Ile Gln Arg Leu Glu 
            180                 185                 190         


Gln Leu Leu Ala Leu Tyr Val Ala Glu Ile Arg Arg Leu Gln Glu Lys 
        195                 200                 205             


Glu Leu Asp Leu Ser Glu Leu Asp Asp Pro Asp Ser Ala Tyr Leu Gln 
    210                 215                 220                 


Glu Ala Arg Leu Lys Arg Lys Leu Ile Arg Leu Phe Gly Arg Leu Cys 
225                 230                 235                 240 


Glu Leu Lys Asp Cys Ser Ser Leu Thr Gly Arg Val Ile Glu Gln Arg 
                245                 250                 255     


Ile Pro Tyr Arg Gly Thr Arg Tyr Pro Glu Val Asn Arg Arg Ile Glu 
            260                 265                 270         


Arg Leu Ile Asn Lys Pro Gly Pro Asp Thr Phe Pro Asp Tyr Gly Asp 
        275                 280                 285             


Val Leu Arg Ala Val Glu Lys Ala Ala Ala Arg His Ser Leu Gly Leu 
    290                 295                 300                 


Pro Arg Gln Gln Leu Gln Leu Met Ala Gln Asp Ala Phe Arg Asp Val 
305                 310                 315                 320 


Gly Ile Arg Leu Gln Glu Arg Arg His Leu Asp Leu Ile Tyr Asn Phe 
                325                 330                 335     


Gly Cys His Leu Thr Asp Asp Tyr Arg Pro Gly Val Asp Pro Ala Leu 
            340                 345                 350         


Ser Asp Pro Val Leu Ala Arg Arg Leu Arg Glu Asn Arg Ser Leu Ala 
        355                 360                 365             


Met Ser Arg Leu Asp Glu Val Ile Ser Lys Tyr Ala Met Leu Gln Asp 
    370                 375                 380                 


Lys Ser Glu Glu Gly Glu Arg Lys Lys Arg Arg Ala Arg Leu Gln Gly 
385                 390                 395                 400 


Thr Ser Ser His Ser Ala Asp Thr Pro Glu Ala Ser Leu Asp Ser Gly 
                405                 410                 415     


Glu Gly Pro Ser Gly Met Ala Ser Gln Gly Cys Pro Ser Ala Ser Arg 
            420                 425                 430         


Ala Glu Thr Asp Asp Glu Asp Asp Glu Glu Ser Asp Glu Glu Glu Glu 
        435                 440                 445             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Thr Asp Ser Glu Glu Glu 
    450                 455                 460                 


Glu Asp Leu Glu Gln Met Gln Glu Gly Gln Glu Asp Asp Glu Glu Glu 
465                 470                 475                 480 


Asp Glu Glu Glu Glu Ala Ala Ala Gly Lys Asp Gly Asp Lys Ser Pro 
                485                 490                 495     


Met Ser Ser Leu Gln Ile Ser Asn Glu Lys Asn Leu Glu Pro Gly Lys 
            500                 505                 510         


Gln Ile Ser Arg Ser Ser Gly Glu Gln Gln Asn Lys Gly Arg Ile Val 
        515                 520                 525             


Ser Pro Ser Leu Leu Ser Glu Glu Pro Leu Ala Pro Ser Ser Ile Asp 
    530                 535                 540                 


Ala Glu Ser Asn Gly Glu Gln Pro Glu Glu Leu Thr Leu Glu Glu Glu 
545                 550                 555                 560 


Ser Pro Val Ser Gln Leu Phe Glu Leu Glu Ile Glu Ala Leu Pro Leu 
                565                 570                 575     


Asp Thr Pro Ser Ser Val Glu Thr Asp Ile Ser Ser Ser Arg Lys Gln 
            580                 585                 590         


Ser Glu Glu Pro Phe Thr Thr Val Leu Glu Asn Gly Ala Gly Met Val 
        595                 600                 605             


Ser Ser Thr Ser Phe Asn Gly Gly Val Ser Pro His Asn Trp Gly Asp 
    610                 615                 620                 


Ser Gly Pro Pro Cys Lys Lys Ser Arg Lys Glu Lys Lys Gln Thr Gly 
625                 630                 635                 640 


Ser Gly Pro Leu Gly Asn Ser Tyr Val Glu Arg Gln Arg Ser Val His 
                645                 650                 655     


Glu Lys Asn Gly Lys Lys Ile Cys Thr Leu Pro Ser Pro Pro Ser Pro 
            660                 665                 670         


Leu Ala Ser Leu Ala Pro Val Ala Asp Ser Ser Thr Arg Val Asp Ser 
        675                 680                 685             


Pro Ser His Gly Leu Val Thr Ser Ser Leu Cys Ile Pro Ser Pro Ala 
    690                 695                 700                 


Arg Leu Ser Gln Thr Pro His Ser Gln Pro Pro Arg Pro Gly Thr Cys 
705                 710                 715                 720 


Lys Thr Ser Val Ala Thr Gln Cys Asp Pro Glu Glu Ile Ile Val Leu 
                725                 730                 735     


Ser Asp Ser Asp 
            740 


<210>  5
<211>  1837
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (112)..(663)

<400>  5
cgctgaggag actccggtca ctgtcctcgc cccgcctccc ccttccctcc ccttggggac       60

caccgggcgc cacgccgcga acgtaatagc tcttcaagtc tgcaataaaa a atg gcc       117
                                                         Met Ala          
                                                         1                

tcc aac aaa act aca ttg caa aaa atg gga aaa aaa cag aat gga aag        165
Ser Asn Lys Thr Thr Leu Gln Lys Met Gly Lys Lys Gln Asn Gly Lys           
        5                   10                  15                        

agt aaa aaa gtt gaa gag gca gag cct gaa gaa ttt gtc gtg gaa aaa        213
Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val Glu Lys           
    20                  25                  30                            

gta cta gat cga cgt gta gtg aat ggg aaa gtg gaa tat ttc ctg aag        261
Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe Leu Lys           
35                  40                  45                  50            

tgg aag gga ttt aca gat gct gac aat act tgg gaa cct gaa gaa aat        309
Trp Lys Gly Phe Thr Asp Ala Asp Asn Thr Trp Glu Pro Glu Glu Asn           
                55                  60                  65                

tta gat tgt cca gaa ttg att gaa gcg ttt ctt aac tct cag aaa gct        357
Leu Asp Cys Pro Glu Leu Ile Glu Ala Phe Leu Asn Ser Gln Lys Ala           
            70                  75                  80                    

ggc aaa gaa aaa gat ggt aca aaa aga aaa tct tta tct gac agt gaa        405
Gly Lys Glu Lys Asp Gly Thr Lys Arg Lys Ser Leu Ser Asp Ser Glu           
        85                  90                  95                        

tct gat gac agc aaa tca aag aag aaa aga gat gct gct gac aaa cca        453
Ser Asp Asp Ser Lys Ser Lys Lys Lys Arg Asp Ala Ala Asp Lys Pro           
    100                 105                 110                           

aga gga ttt gcc aga ggt ctt gat cct gaa aga ata att ggt gcc aca        501
Arg Gly Phe Ala Arg Gly Leu Asp Pro Glu Arg Ile Ile Gly Ala Thr           
115                 120                 125                 130           

gac agc agt gga gaa ttg atg ttt ctc atg aaa tgg aaa gat tca gat        549
Asp Ser Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asp Ser Asp           
                135                 140                 145               

gag gca gac ttg gtg ctg gcg aaa gag gca aat atg aag tgt cct caa        597
Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Met Lys Cys Pro Gln           
            150                 155                 160                   

att gta att gct ttt tat gaa gag aga cta act tgg cat tct tgt cca        645
Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ser Cys Pro           
        165                 170                 175                       

gaa gat gaa gct caa taa ttgttcacat tgttctttta tatatattta               693
Glu Asp Glu Ala Gln                                                       
    180                                                                   

tatatatata taaaaattgg gtcttagatt ttgatttact agtgtgacaa aataactaca      753

tcctaatgaa aatcaagttt gatatgtttg ttttgaaagt agcgttggaa gagttgttgg      813

gggttttttg catccatagc actggttact ttgaacaaat aaataaaagc tttctgtagt      873

tgcttccttt atcagaaaag aacatttgat accatggtat atcatttcct cttcattaaa      933

gaacagcttt tctaaatgtt gggggaaatg tccatagtca ttactcagtc aaaacttgtg      993

ttctcatgag cctaaggacc attctagatt tattacgtgt tttttgtgtg tgtgtgtgtg     1053

tgtgtgtgtg tgtgtatcca taaaatgcat atgtaaattt ttttttgttt ttaagcattc     1113

acccaaacaa aaaaatcaca ggtaaaccca tgtttctgag atgccattat tccaagcaaa     1173

ataagagata atcccttcaa gttaaattga aaattttcct gaaaccatac atttcaagtg     1233

aaataagtaa ttctagatag gacaatttaa attggataat tttaaagtgt ctataattgc     1293

agtggtttat ttgcaaaatt cctaaaagga aaaattttat cactgccatc acagcaggtt     1353

tcctcatcca gatgaggaaa ctagacaaat gctagtgtgt tttaactagc taaacaaaac     1413

taagttaaat gaacatttaa aagtttccct agcgggccat tccttagcaa aatgttggaa     1473

tccctgttgc tacattgact aaaaggtcat gatgaatgga atatgtaaga cttggctcat     1533

agaaacctaa tcagatggtt agaggtgttg gcagtttagg acctgctgtc ataaatgtgt     1593

gaacaacctt ttgtaaccta acctattgac ctgcatgttt tttctttacc ccaattcatt     1653

acatggaggc tcaatcttga gtttgcttta ctggttcagc aaaagccagg aagaacaact     1713

ttgtagtaat caaaatgtta tccaactgta tattgtttac tttattgtaa atactggtga     1773

acagtggtta ataaatagtt ttatattcct ttatgcaaaa aaaaaaaaaa aaaaaaaaaa     1833

aaaa                                                                  1837


<210>  6
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ser Asn Lys Thr Thr Leu Gln Lys Met Gly Lys Lys Gln Asn 
1               5                   10                  15      


Gly Lys Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val 
            20                  25                  30          


Glu Lys Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe 
        35                  40                  45              


Leu Lys Trp Lys Gly Phe Thr Asp Ala Asp Asn Thr Trp Glu Pro Glu 
    50                  55                  60                  


Glu Asn Leu Asp Cys Pro Glu Leu Ile Glu Ala Phe Leu Asn Ser Gln 
65                  70                  75                  80  


Lys Ala Gly Lys Glu Lys Asp Gly Thr Lys Arg Lys Ser Leu Ser Asp 
                85                  90                  95      


Ser Glu Ser Asp Asp Ser Lys Ser Lys Lys Lys Arg Asp Ala Ala Asp 
            100                 105                 110         


Lys Pro Arg Gly Phe Ala Arg Gly Leu Asp Pro Glu Arg Ile Ile Gly 
        115                 120                 125             


Ala Thr Asp Ser Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Ser Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Met Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ser 
                165                 170                 175     


Cys Pro Glu Asp Glu Ala Gln 
            180             


<210>  7
<211>  3284
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (438)..(2255)

<400>  7
aaagcgcatg cgccagctag atgggcagcg aggagagccg caactgccag tccctcgaag       60

gggttagctg tcgttgaacg tcagcacgca gatgcaactg gctctcggca ggggggcgcg      120

cgcaccgctg cggagcgccg gcccgtaggc gcgggagcct ccctattaag ggcacgcgac      180

atcgaggcaa tagtgcgcag gtgcttagcc agaggcggag cccgagaggc aggcagcgga      240

cttccggttc cgggagcaac gaacagccgc ggaggcgaca gctaccgctt cagaggaggc      300

ggccgcggag gaggaggaag gggaggaggg cgaggcggga ggtgcaggag ggaccctcgc      360

catgggtcca cgggcctaga gtggcggaag ataccggcct ggtgccaaac tggctactgc      420

tgcttcctgt ggcctcc atg gct gag gac tgg ctg gac tgc ccg gcc ctg         470
                   Met Ala Glu Asp Trp Leu Asp Cys Pro Ala Leu            
                   1               5                   10                 

ggc cct ggc tgg aag cgc cgc gaa gtc ttt cgc aag tca ggg gcc acc        518
Gly Pro Gly Trp Lys Arg Arg Glu Val Phe Arg Lys Ser Gly Ala Thr           
            15                  20                  25                    

tgt gga cgc tca gac acc tat tac cag agc ccc aca gga gac agg atc        566
Cys Gly Arg Ser Asp Thr Tyr Tyr Gln Ser Pro Thr Gly Asp Arg Ile           
        30                  35                  40                        

cga agc aaa gtt gag ctg act cga tac ctg ggc cct gcg tgt gat ctc        614
Arg Ser Lys Val Glu Leu Thr Arg Tyr Leu Gly Pro Ala Cys Asp Leu           
    45                  50                  55                            

acc ctc ttc gac ttc aaa caa ggc atc ttg tgc tat cca gcc ccc aag        662
Thr Leu Phe Asp Phe Lys Gln Gly Ile Leu Cys Tyr Pro Ala Pro Lys           
60                  65                  70                  75            

gcc cat ccc gtg gcg gtt gcc agc aag aag cga aag aag cct tca agg        710
Ala His Pro Val Ala Val Ala Ser Lys Lys Arg Lys Lys Pro Ser Arg           
                80                  85                  90                

cca gcc aag act cgg aaa cgt cag gtt gga ccc cag agt ggt gag gtc        758
Pro Ala Lys Thr Arg Lys Arg Gln Val Gly Pro Gln Ser Gly Glu Val           
            95                  100                 105                   

agg aag gag gcc ccg agg gat gag acc aag gct gac act gac aca gcc        806
Arg Lys Glu Ala Pro Arg Asp Glu Thr Lys Ala Asp Thr Asp Thr Ala           
        110                 115                 120                       

cca gct tca ttc cct gct cct ggg tgc tgt gag aac tgt gga atc agc        854
Pro Ala Ser Phe Pro Ala Pro Gly Cys Cys Glu Asn Cys Gly Ile Ser           
    125                 130                 135                           

ttc tca ggg gat ggc acc caa agg cag cgg ctc aaa acg ttg tgc aaa        902
Phe Ser Gly Asp Gly Thr Gln Arg Gln Arg Leu Lys Thr Leu Cys Lys           
140                 145                 150                 155           

gac tgt cga gca cag aga att gcc ttc aac cgg gaa cag aga atg ttt        950
Asp Cys Arg Ala Gln Arg Ile Ala Phe Asn Arg Glu Gln Arg Met Phe           
                160                 165                 170               

aag cgt gtg ggc tgt ggg gag tgt gca gcc tgc cag gta aca gaa gac        998
Lys Arg Val Gly Cys Gly Glu Cys Ala Ala Cys Gln Val Thr Glu Asp           
            175                 180                 185                   

tgt ggg gcc tgc tcc acc tgc ctc ctg cag ctg ccc cat gat gtg gca       1046
Cys Gly Ala Cys Ser Thr Cys Leu Leu Gln Leu Pro His Asp Val Ala           
        190                 195                 200                       

tcg ggg ctg ttc tgc aag tgt gaa cgg aga cgc tgc ctc cgg att gtg       1094
Ser Gly Leu Phe Cys Lys Cys Glu Arg Arg Arg Cys Leu Arg Ile Val           
    205                 210                 215                           

gaa agg agc cga ggg tgt gga gta tgc cgg ggc tgt cag acc caa gag       1142
Glu Arg Ser Arg Gly Cys Gly Val Cys Arg Gly Cys Gln Thr Gln Glu           
220                 225                 230                 235           

gat tgt ggc cat tgc ccc atc tgc ctt cgc cct ccc cgc cct ggt ctc       1190
Asp Cys Gly His Cys Pro Ile Cys Leu Arg Pro Pro Arg Pro Gly Leu           
                240                 245                 250               

agg cgc cag tgg aaa tgt gtc cag cga cgt tgc cta cgg ggt aaa cat       1238
Arg Arg Gln Trp Lys Cys Val Gln Arg Arg Cys Leu Arg Gly Lys His           
            255                 260                 265                   

gcc cgc cgc aag gga ggc tgt gac tcc aag atg gct gcc agg cgg cgc       1286
Ala Arg Arg Lys Gly Gly Cys Asp Ser Lys Met Ala Ala Arg Arg Arg           
        270                 275                 280                       

ccc gga gcc cag cca ctg cct cca cca ccc cca tca cag tcc cca gag       1334
Pro Gly Ala Gln Pro Leu Pro Pro Pro Pro Pro Ser Gln Ser Pro Glu           
    285                 290                 295                           

ccc aca gag ccg cac ccc aga gcc ctg gcc ccc tcg cca cct gcc gag       1382
Pro Thr Glu Pro His Pro Arg Ala Leu Ala Pro Ser Pro Pro Ala Glu           
300                 305                 310                 315           

ttc atc tat tac tgt gta gac gag gac gag cta cag ccc tac acg aac       1430
Phe Ile Tyr Tyr Cys Val Asp Glu Asp Glu Leu Gln Pro Tyr Thr Asn           
                320                 325                 330               

cgc cgg cag aac cgc aag tgc ggg gcc tgt gca gcc tgc cta cgg cgg       1478
Arg Arg Gln Asn Arg Lys Cys Gly Ala Cys Ala Ala Cys Leu Arg Arg           
            335                 340                 345                   

atg gac tgt ggc cgc tgc gac ttc tgc tgc gac aag ccc aaa ttc ggg       1526
Met Asp Cys Gly Arg Cys Asp Phe Cys Cys Asp Lys Pro Lys Phe Gly           
        350                 355                 360                       

ggc agc aac cag aag cgc cag aag tgt cgt tgg cgc caa tgc ctg cag       1574
Gly Ser Asn Gln Lys Arg Gln Lys Cys Arg Trp Arg Gln Cys Leu Gln           
    365                 370                 375                           

ttt gcc atg aag cgg ctg ctg ccc agt gtc tgg tca gag tct gag gat       1622
Phe Ala Met Lys Arg Leu Leu Pro Ser Val Trp Ser Glu Ser Glu Asp           
380                 385                 390                 395           

ggg gca gga tcg ccc cca cct tac cgt cgt cga aag agg ccc agc tct       1670
Gly Ala Gly Ser Pro Pro Pro Tyr Arg Arg Arg Lys Arg Pro Ser Ser           
                400                 405                 410               

gcc cga cgg cac cat ctt ggc cct acc ttg aag ccc acc ttg gct aca       1718
Ala Arg Arg His His Leu Gly Pro Thr Leu Lys Pro Thr Leu Ala Thr           
            415                 420                 425                   

cgc aca gcc caa cca gac cat acc cag gct cca acg aag cag gaa gca       1766
Arg Thr Ala Gln Pro Asp His Thr Gln Ala Pro Thr Lys Gln Glu Ala           
        430                 435                 440                       

ggt ggt ggc ttt gtg ctg ccc ccg cct ggc act gac ctt gtg ttt tta       1814
Gly Gly Gly Phe Val Leu Pro Pro Pro Gly Thr Asp Leu Val Phe Leu           
    445                 450                 455                           

cgg gaa ggc gca agc agt cct gtg cag gtg ccg ggc cct gtt gca gct       1862
Arg Glu Gly Ala Ser Ser Pro Val Gln Val Pro Gly Pro Val Ala Ala           
460                 465                 470                 475           

tcc aca gaa gcc ctg ttg cag gag gcc cag tgc tct ggc ctg agt tgg       1910
Ser Thr Glu Ala Leu Leu Gln Glu Ala Gln Cys Ser Gly Leu Ser Trp           
                480                 485                 490               

gtt gtg gcc tta ccc cag gtg aag caa gag aag gcg gat acc cag gac       1958
Val Val Ala Leu Pro Gln Val Lys Gln Glu Lys Ala Asp Thr Gln Asp           
            495                 500                 505                   

gag tgg aca cca ggc aca gct gtc ctg act tct ccc gta ttg gtg cct       2006
Glu Trp Thr Pro Gly Thr Ala Val Leu Thr Ser Pro Val Leu Val Pro           
        510                 515                 520                       

ggc tgc cct agc aag gca gta gac cca ggc ctg cct tct gtg aag caa       2054
Gly Cys Pro Ser Lys Ala Val Asp Pro Gly Leu Pro Ser Val Lys Gln           
    525                 530                 535                           

gag cca cct gac cca gag gag gac aag gag gag aac aag gat gat tct       2102
Glu Pro Pro Asp Pro Glu Glu Asp Lys Glu Glu Asn Lys Asp Asp Ser           
540                 545                 550                 555           

gcc tcc aaa ttg gcc cca gag gaa gag gca gga ggg gct ggc aca ccc       2150
Ala Ser Lys Leu Ala Pro Glu Glu Glu Ala Gly Gly Ala Gly Thr Pro           
                560                 565                 570               

gtg atc acg gag att ttc agc ctg ggt gga acc cgc ttc cga gat aca       2198
Val Ile Thr Glu Ile Phe Ser Leu Gly Gly Thr Arg Phe Arg Asp Thr           
            575                 580                 585                   

gca gtc tgg ttg cca agg tcc aaa gac ctt aaa aaa cct gga gct aga       2246
Ala Val Trp Leu Pro Arg Ser Lys Asp Leu Lys Lys Pro Gly Ala Arg           
        590                 595                 600                       

aag cag tag actggaggct tctacagact gtaggattca agtctgcagg               2295
Lys Gln                                                                   
    605                                                                   

gcaggcactc gggaagggaa gatggatgta aagtgtggga gaccgaggac acagtggagc     2355

ccacgagcac gagctggaac ccacgaggat ggcctggaac ccatgtcagt ctctcaccac     2415

ctccagcttc gatgatgtgg gtgtcctgca gaagaagctg gtgcccttcc tcacagagtt     2475

aaatatgcat ctggcccagg aattagagaa gctgaaagga tgatcctggg gaaggtggag     2535

cagctgcagg cctggctgca ggcctgacta ctgcccacac caacgaggtg atctagcaga     2595

tacatggcaa cgtgtgaact gcaacaacgc ctggtgcccc agcaccaacc ttccaagtgt     2655

aaaaacaatg tgctgctgct tcacttccgc cctccggtta tcaagcaaaa tgtctcttgt     2715

ggcccatctt actggaagag agttccggga aacatagcct caccaaggtg acacattaca     2775

aagccaccct accatgaatc cgctcccaag ggtctcactg ctcacctgag gataactcaa     2835

tataactatg tggctgaaaa tgcaaagctg aagaccatgg atttcatggt gattccagca     2895

agtacagaga ttctatgaag cccacccaga aaaaacttgc tggtcctggc tatttttgtg     2955

tcatttattc aagtattgag aacctggcct gtggtaggca ctgtacttaa tactaggata     3015

cagaaatgca aaagatacgg cccatgcaat tttattaaat gcatcaatat gtattacaaa     3075

tggtgaatgg atttccaact ttatcatgga atttaatgct gaatatatag aattcagaaa     3135

attgttggga ggacagccct tttgtgaacc ttgtttgggg cacagtagga attggaaata     3195

atttagtttc tatctctaag ctgttctatt ttaaaattat ttttaaattt ttattgtccc     3255

acttaaaaaa aaaaaaaaaa aaaaaaaaa                                       3284


<210>  8
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Glu Asp Trp Leu Asp Cys Pro Ala Leu Gly Pro Gly Trp Lys 
1               5                   10                  15      


Arg Arg Glu Val Phe Arg Lys Ser Gly Ala Thr Cys Gly Arg Ser Asp 
            20                  25                  30          


Thr Tyr Tyr Gln Ser Pro Thr Gly Asp Arg Ile Arg Ser Lys Val Glu 
        35                  40                  45              


Leu Thr Arg Tyr Leu Gly Pro Ala Cys Asp Leu Thr Leu Phe Asp Phe 
    50                  55                  60                  


Lys Gln Gly Ile Leu Cys Tyr Pro Ala Pro Lys Ala His Pro Val Ala 
65                  70                  75                  80  


Val Ala Ser Lys Lys Arg Lys Lys Pro Ser Arg Pro Ala Lys Thr Arg 
                85                  90                  95      


Lys Arg Gln Val Gly Pro Gln Ser Gly Glu Val Arg Lys Glu Ala Pro 
            100                 105                 110         


Arg Asp Glu Thr Lys Ala Asp Thr Asp Thr Ala Pro Ala Ser Phe Pro 
        115                 120                 125             


Ala Pro Gly Cys Cys Glu Asn Cys Gly Ile Ser Phe Ser Gly Asp Gly 
    130                 135                 140                 


Thr Gln Arg Gln Arg Leu Lys Thr Leu Cys Lys Asp Cys Arg Ala Gln 
145                 150                 155                 160 


Arg Ile Ala Phe Asn Arg Glu Gln Arg Met Phe Lys Arg Val Gly Cys 
                165                 170                 175     


Gly Glu Cys Ala Ala Cys Gln Val Thr Glu Asp Cys Gly Ala Cys Ser 
            180                 185                 190         


Thr Cys Leu Leu Gln Leu Pro His Asp Val Ala Ser Gly Leu Phe Cys 
        195                 200                 205             


Lys Cys Glu Arg Arg Arg Cys Leu Arg Ile Val Glu Arg Ser Arg Gly 
    210                 215                 220                 


Cys Gly Val Cys Arg Gly Cys Gln Thr Gln Glu Asp Cys Gly His Cys 
225                 230                 235                 240 


Pro Ile Cys Leu Arg Pro Pro Arg Pro Gly Leu Arg Arg Gln Trp Lys 
                245                 250                 255     


Cys Val Gln Arg Arg Cys Leu Arg Gly Lys His Ala Arg Arg Lys Gly 
            260                 265                 270         


Gly Cys Asp Ser Lys Met Ala Ala Arg Arg Arg Pro Gly Ala Gln Pro 
        275                 280                 285             


Leu Pro Pro Pro Pro Pro Ser Gln Ser Pro Glu Pro Thr Glu Pro His 
    290                 295                 300                 


Pro Arg Ala Leu Ala Pro Ser Pro Pro Ala Glu Phe Ile Tyr Tyr Cys 
305                 310                 315                 320 


Val Asp Glu Asp Glu Leu Gln Pro Tyr Thr Asn Arg Arg Gln Asn Arg 
                325                 330                 335     


Lys Cys Gly Ala Cys Ala Ala Cys Leu Arg Arg Met Asp Cys Gly Arg 
            340                 345                 350         


Cys Asp Phe Cys Cys Asp Lys Pro Lys Phe Gly Gly Ser Asn Gln Lys 
        355                 360                 365             


Arg Gln Lys Cys Arg Trp Arg Gln Cys Leu Gln Phe Ala Met Lys Arg 
    370                 375                 380                 


Leu Leu Pro Ser Val Trp Ser Glu Ser Glu Asp Gly Ala Gly Ser Pro 
385                 390                 395                 400 


Pro Pro Tyr Arg Arg Arg Lys Arg Pro Ser Ser Ala Arg Arg His His 
                405                 410                 415     


Leu Gly Pro Thr Leu Lys Pro Thr Leu Ala Thr Arg Thr Ala Gln Pro 
            420                 425                 430         


Asp His Thr Gln Ala Pro Thr Lys Gln Glu Ala Gly Gly Gly Phe Val 
        435                 440                 445             


Leu Pro Pro Pro Gly Thr Asp Leu Val Phe Leu Arg Glu Gly Ala Ser 
    450                 455                 460                 


Ser Pro Val Gln Val Pro Gly Pro Val Ala Ala Ser Thr Glu Ala Leu 
465                 470                 475                 480 


Leu Gln Glu Ala Gln Cys Ser Gly Leu Ser Trp Val Val Ala Leu Pro 
                485                 490                 495     


Gln Val Lys Gln Glu Lys Ala Asp Thr Gln Asp Glu Trp Thr Pro Gly 
            500                 505                 510         


Thr Ala Val Leu Thr Ser Pro Val Leu Val Pro Gly Cys Pro Ser Lys 
        515                 520                 525             


Ala Val Asp Pro Gly Leu Pro Ser Val Lys Gln Glu Pro Pro Asp Pro 
    530                 535                 540                 


Glu Glu Asp Lys Glu Glu Asn Lys Asp Asp Ser Ala Ser Lys Leu Ala 
545                 550                 555                 560 


Pro Glu Glu Glu Ala Gly Gly Ala Gly Thr Pro Val Ile Thr Glu Ile 
                565                 570                 575     


Phe Ser Leu Gly Gly Thr Arg Phe Arg Asp Thr Ala Val Trp Leu Pro 
            580                 585                 590         


Arg Ser Lys Asp Leu Lys Lys Pro Gly Ala Arg Lys Gln 
        595                 600                 605 


<210>  9
<211>  2584
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (230)..(1465)

<400>  9
gggggcgtgg ccccgagaag gcggagacaa gatggccgcc catagcgctt ggaggaccta       60

agaggcggtg gccggggcca cgccccgggc aggagggccg ctctgtgcgc gcccgctcta      120

tgatgcttgc gcgcgtcccc cgcgcgccgc gctgcgggcg gggcgggtct ccgggattcc      180

aagggctcgg ttacggaaga agcgcagcgc cggctgggga gggggctgg atg cgc gcg      238
                                                      Met Arg Ala         
                                                      1                   

cac ccg ggg gga ggc cgc tgc tgc ccg gag cag gag gag ggg gag agt        286
His Pro Gly Gly Gly Arg Cys Cys Pro Glu Gln Glu Glu Gly Glu Ser           
    5                   10                  15                            

gcg gcg ggc ggc agc ggc gct ggc ggc gac tcc gcc ata gag cag ggg        334
Ala Ala Gly Gly Ser Gly Ala Gly Gly Asp Ser Ala Ile Glu Gln Gly           
20                  25                  30                  35            

ggc cag ggc agc gcg ctc gcc ccg tcc ccg gtg agc ggc gtg cgc agg        382
Gly Gln Gly Ser Ala Leu Ala Pro Ser Pro Val Ser Gly Val Arg Arg           
                40                  45                  50                

gaa ggc gct cgg ggc ggc ggc cgt ggc cgg ggg cgg tgg aag cag gcg        430
Glu Gly Ala Arg Gly Gly Gly Arg Gly Arg Gly Arg Trp Lys Gln Ala           
            55                  60                  65                    

ggc cgg ggc ggc ggc gtc tgt ggc cgt ggc cgg ggc cgg ggc cgt ggc        478
Gly Arg Gly Gly Gly Val Cys Gly Arg Gly Arg Gly Arg Gly Arg Gly           
        70                  75                  80                        

cgg gga cgg gga cgg ggc cgg ggc cgg ggc cgc ggc cgt ccc ccg agt        526
Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Pro Pro Ser           
    85                  90                  95                            

ggc ggc agc ggc ctt ggc ggc gac ggc ggc ggc tgc ggc ggc ggc ggc        574
Gly Gly Ser Gly Leu Gly Gly Asp Gly Gly Gly Cys Gly Gly Gly Gly           
100                 105                 110                 115           

agc ggt ggc ggc ggc gcc ccc cgg cgg gag ccg gtc cct ttc ccg tcg        622
Ser Gly Gly Gly Gly Ala Pro Arg Arg Glu Pro Val Pro Phe Pro Ser           
                120                 125                 130               

ggg agc gcg ggg ccg ggg ccc agg gga ccc cgg gcc acg gag agc ggg        670
Gly Ser Ala Gly Pro Gly Pro Arg Gly Pro Arg Ala Thr Glu Ser Gly           
            135                 140                 145                   

aag agg atg gat tgc ccg gcc ctc ccc ccc gga tgg aag aag gag gaa        718
Lys Arg Met Asp Cys Pro Ala Leu Pro Pro Gly Trp Lys Lys Glu Glu           
        150                 155                 160                       

gtg atc cga aaa tct ggg cta agt gct ggc aag agc gat gtc tac tac        766
Val Ile Arg Lys Ser Gly Leu Ser Ala Gly Lys Ser Asp Val Tyr Tyr           
    165                 170                 175                           

ttc agt cca agt ggt aag aag ttc aga agc aag cct cag ttg gca agg        814
Phe Ser Pro Ser Gly Lys Lys Phe Arg Ser Lys Pro Gln Leu Ala Arg           
180                 185                 190                 195           

tac ctg gga aat act gtt gat ctc agc agt ttt gac ttc aga act gga        862
Tyr Leu Gly Asn Thr Val Asp Leu Ser Ser Phe Asp Phe Arg Thr Gly           
                200                 205                 210               

aag atg atg cct agt aaa tta cag aag aac aaa cag aga ctg cga aac        910
Lys Met Met Pro Ser Lys Leu Gln Lys Asn Lys Gln Arg Leu Arg Asn           
            215                 220                 225                   

gat cct ctc aat caa aat aag ggt aaa cca gac ttg aat aca aca ttg        958
Asp Pro Leu Asn Gln Asn Lys Gly Lys Pro Asp Leu Asn Thr Thr Leu           
        230                 235                 240                       

cca att aga caa aca gca tca att ttc aaa caa ccg gta acc aaa gtc       1006
Pro Ile Arg Gln Thr Ala Ser Ile Phe Lys Gln Pro Val Thr Lys Val           
    245                 250                 255                           

aca aat cat cct agt aat aaa gtg aaa tca gac cca caa cga atg aat       1054
Thr Asn His Pro Ser Asn Lys Val Lys Ser Asp Pro Gln Arg Met Asn           
260                 265                 270                 275           

gaa cag cca cgt cag ctt ttc tgg gag aag agg cta caa gga ctt agt       1102
Glu Gln Pro Arg Gln Leu Phe Trp Glu Lys Arg Leu Gln Gly Leu Ser           
                280                 285                 290               

gca tca gat gta aca gaa caa att ata aaa acc atg gaa cta ccc aaa       1150
Ala Ser Asp Val Thr Glu Gln Ile Ile Lys Thr Met Glu Leu Pro Lys           
            295                 300                 305                   

ggt ctt caa gga gtt ggt cca ggt agc aat gat gag acc ctt tta tct       1198
Gly Leu Gln Gly Val Gly Pro Gly Ser Asn Asp Glu Thr Leu Leu Ser           
        310                 315                 320                       

gct gtt gcc agt gct ttg cac aca agc tct gcg cca atc aca ggg caa       1246
Ala Val Ala Ser Ala Leu His Thr Ser Ser Ala Pro Ile Thr Gly Gln           
    325                 330                 335                           

gtc tcc gct gct gtg gaa aag aac cct gct gtt tgg ctt aac aca tct       1294
Val Ser Ala Ala Val Glu Lys Asn Pro Ala Val Trp Leu Asn Thr Ser           
340                 345                 350                 355           

caa ccc ctc tgc aaa gct ttt att gtc aca gat gaa gac atc agg aaa       1342
Gln Pro Leu Cys Lys Ala Phe Ile Val Thr Asp Glu Asp Ile Arg Lys           
                360                 365                 370               

cag gaa gag cga gta cag caa gta cgc aag aaa ttg gaa gaa gca ctg       1390
Gln Glu Glu Arg Val Gln Gln Val Arg Lys Lys Leu Glu Glu Ala Leu           
            375                 380                 385                   

atg gca gac atc ttg tcg cga gct gct gat aca gaa gag atg gat att       1438
Met Ala Asp Ile Leu Ser Arg Ala Ala Asp Thr Glu Glu Met Asp Ile           
        390                 395                 400                       

gaa atg gac agt gga gat gaa gcc taa gaatatgatc aggtaacttt             1485
Glu Met Asp Ser Gly Asp Glu Ala                                           
    405                 410                                               

cgaccgactt tccccaagag aaaattccta gaaattgaac aaaaatgttt ccactggctt     1545

ttgcctgtaa gaaaaaaaat gtacccgagc acatagagct ttttaatagc actaaccaat     1605

gcctttttag atgtattttt gatgtatata tctattattc aaaaaatcat gtttattttg     1665

agtcctagga cttaaaatta gtcttttgta atatcaagca ggaccctaag atgaagctga     1725

gcttttgatg ccaggtgcaa tctactggaa atgtagcact tacgtaaaac atttgtttcc     1785

cccacagttt taataagaac agatcaggaa ttctaaataa atttcccagt taaagattat     1845

tgtgacttca ctgtatataa acatattttt atactttatt gaaaggggac acctgtacat     1905

tcttccatca tcactgtaaa gacaaataaa tgattatatt cacagactga ttggaattct     1965

ttctgttgaa aagcacacac aataaagaac ccctcgttag ccttcctctg atttacattc     2025

aactctgatc cctgggcctt aggtttgaca tggaggtgga ggaagatagc gcatatattt     2085

gcagtatgaa ctattgcctc tggacgttgt gagaattgtg ctttcaccag aatttctaag     2145

aatttctgct aaatatcacc tagcatgtgt aatttttttt ccttgcctgt gacttggact     2205

tttgatagtt ctataagaat aaggcttttt cttcccttgg gcatgagtca gatacacaag     2265

gacccttcag gtgttactag aaggcgtcca tgtttattgt tttttaaaga atgtttggca     2325

ctctctaacg tccactagct tactgagtta tcaggtgcag gtcagactct tggctacagt     2385

gagaggcagc ttctaggcag agttgcttaa tgaaagggtt tgtaatactt tacaaaccat     2445

tacctgtacc tggcctggcc tccaaaatat taacattctt tttctgttga aactcgcgag     2505

tgtaactttc ataccacttg aatttattga tatttaatta tgaaaactag cattacatta     2565

ttaaacgatt tctaaaatc                                                  2584


<210>  10
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Ala His Pro Gly Gly Gly Arg Cys Cys Pro Glu Gln Glu Glu 
1               5                   10                  15      


Gly Glu Ser Ala Ala Gly Gly Ser Gly Ala Gly Gly Asp Ser Ala Ile 
            20                  25                  30          


Glu Gln Gly Gly Gln Gly Ser Ala Leu Ala Pro Ser Pro Val Ser Gly 
        35                  40                  45              


Val Arg Arg Glu Gly Ala Arg Gly Gly Gly Arg Gly Arg Gly Arg Trp 
    50                  55                  60                  


Lys Gln Ala Gly Arg Gly Gly Gly Val Cys Gly Arg Gly Arg Gly Arg 
65                  70                  75                  80  


Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
                85                  90                  95      


Pro Pro Ser Gly Gly Ser Gly Leu Gly Gly Asp Gly Gly Gly Cys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Arg Arg Glu Pro Val Pro 
        115                 120                 125             


Phe Pro Ser Gly Ser Ala Gly Pro Gly Pro Arg Gly Pro Arg Ala Thr 
    130                 135                 140                 


Glu Ser Gly Lys Arg Met Asp Cys Pro Ala Leu Pro Pro Gly Trp Lys 
145                 150                 155                 160 


Lys Glu Glu Val Ile Arg Lys Ser Gly Leu Ser Ala Gly Lys Ser Asp 
                165                 170                 175     


Val Tyr Tyr Phe Ser Pro Ser Gly Lys Lys Phe Arg Ser Lys Pro Gln 
            180                 185                 190         


Leu Ala Arg Tyr Leu Gly Asn Thr Val Asp Leu Ser Ser Phe Asp Phe 
        195                 200                 205             


Arg Thr Gly Lys Met Met Pro Ser Lys Leu Gln Lys Asn Lys Gln Arg 
    210                 215                 220                 


Leu Arg Asn Asp Pro Leu Asn Gln Asn Lys Gly Lys Pro Asp Leu Asn 
225                 230                 235                 240 


Thr Thr Leu Pro Ile Arg Gln Thr Ala Ser Ile Phe Lys Gln Pro Val 
                245                 250                 255     


Thr Lys Val Thr Asn His Pro Ser Asn Lys Val Lys Ser Asp Pro Gln 
            260                 265                 270         


Arg Met Asn Glu Gln Pro Arg Gln Leu Phe Trp Glu Lys Arg Leu Gln 
        275                 280                 285             


Gly Leu Ser Ala Ser Asp Val Thr Glu Gln Ile Ile Lys Thr Met Glu 
    290                 295                 300                 


Leu Pro Lys Gly Leu Gln Gly Val Gly Pro Gly Ser Asn Asp Glu Thr 
305                 310                 315                 320 


Leu Leu Ser Ala Val Ala Ser Ala Leu His Thr Ser Ser Ala Pro Ile 
                325                 330                 335     


Thr Gly Gln Val Ser Ala Ala Val Glu Lys Asn Pro Ala Val Trp Leu 
            340                 345                 350         


Asn Thr Ser Gln Pro Leu Cys Lys Ala Phe Ile Val Thr Asp Glu Asp 
        355                 360                 365             


Ile Arg Lys Gln Glu Glu Arg Val Gln Gln Val Arg Lys Lys Leu Glu 
    370                 375                 380                 


Glu Ala Leu Met Ala Asp Ile Leu Ser Arg Ala Ala Asp Thr Glu Glu 
385                 390                 395                 400 


Met Asp Ile Glu Met Asp Ser Gly Asp Glu Ala 
                405                 410     


<210>  11
<211>  2559
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (23)..(898)

<400>  11
gcgggccgag gagccgggcg ca atg gag cgg aag agg tgg gag tgc ccg gcg        52
                         Met Glu Arg Lys Arg Trp Glu Cys Pro Ala          
                         1               5                   10           

ctc ccg cag ggc tgg gag agg gaa gaa gtg ccc aga agg tcg ggg ctg        100
Leu Pro Gln Gly Trp Glu Arg Glu Glu Val Pro Arg Arg Ser Gly Leu           
                15                  20                  25                

tcg gcc ggc cac agg gat gtc ttt tac tat agc ccg agc ggg aag aag        148
Ser Ala Gly His Arg Asp Val Phe Tyr Tyr Ser Pro Ser Gly Lys Lys           
            30                  35                  40                    

ttc cgc agc aag ccg cag ctg gcg cgc tac ctg ggc ggc tcc atg gac        196
Phe Arg Ser Lys Pro Gln Leu Ala Arg Tyr Leu Gly Gly Ser Met Asp           
        45                  50                  55                        

ctg agc acc ttc gac ttc cgc acg ggc aag atg ctg atg agc aag atg        244
Leu Ser Thr Phe Asp Phe Arg Thr Gly Lys Met Leu Met Ser Lys Met           
    60                  65                  70                            

aac aag agc cgc cag cgc gtg cgc tac gac tcc tcc aac cag gtc aag        292
Asn Lys Ser Arg Gln Arg Val Arg Tyr Asp Ser Ser Asn Gln Val Lys           
75                  80                  85                  90            

ggc aag ccc gac ctg aac acg gcg ctg ccc gtg cgc cag acg gcg tcc        340
Gly Lys Pro Asp Leu Asn Thr Ala Leu Pro Val Arg Gln Thr Ala Ser           
                95                  100                 105               

atc ttc aag cag ccg gtg acc aag att acc aac cac ccc agc aac aag        388
Ile Phe Lys Gln Pro Val Thr Lys Ile Thr Asn His Pro Ser Asn Lys           
            110                 115                 120                   

gtc aag agc gac ccg cag aag gcg gtg gac cag ccg cgc cag ctc ttc        436
Val Lys Ser Asp Pro Gln Lys Ala Val Asp Gln Pro Arg Gln Leu Phe           
        125                 130                 135                       

tgg gag aag aag ctg agc ggc ctg aac gcc ttc gac att gct gag gag        484
Trp Glu Lys Lys Leu Ser Gly Leu Asn Ala Phe Asp Ile Ala Glu Glu           
    140                 145                 150                           

ctg gtc aag acc atg gac ctc ccc aag ggc ctg cag ggg gtg gga cct        532
Leu Val Lys Thr Met Asp Leu Pro Lys Gly Leu Gln Gly Val Gly Pro           
155                 160                 165                 170           

ggc tgc acg gat gag acg ctg ctg tcg gcc atc gcc agc gcc ctg cac        580
Gly Cys Thr Asp Glu Thr Leu Leu Ser Ala Ile Ala Ser Ala Leu His           
                175                 180                 185               

act agc acc atg ccc atc acg gga cag ctc tcg gcc gcc gtg gag aag        628
Thr Ser Thr Met Pro Ile Thr Gly Gln Leu Ser Ala Ala Val Glu Lys           
            190                 195                 200                   

aac ccc ggc gta tgg ctc aac acc acg cag ccc ctg tgc aaa gcc ttc        676
Asn Pro Gly Val Trp Leu Asn Thr Thr Gln Pro Leu Cys Lys Ala Phe           
        205                 210                 215                       

atg gtg acc gac gag gac atc agg aag cag gaa gag ctg gtg cag cag        724
Met Val Thr Asp Glu Asp Ile Arg Lys Gln Glu Glu Leu Val Gln Gln           
    220                 225                 230                           

gtg cgg aag cgg ctg gag gag gcg ctg atg gcc gac atg ctg gcg cac        772
Val Arg Lys Arg Leu Glu Glu Ala Leu Met Ala Asp Met Leu Ala His           
235                 240                 245                 250           

gtg gag gag ctg gcc cgt gac ggg gag gcg ccg ctg gac aag gcc tgc        820
Val Glu Glu Leu Ala Arg Asp Gly Glu Ala Pro Leu Asp Lys Ala Cys           
                255                 260                 265               

gct gag gac gac gac gag gaa gac gag gag gag gag gag gag gag ccc        868
Ala Glu Asp Asp Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Pro           
            270                 275                 280                   

gac ccg gac ccg gag atg gag cac gtc tag ggcaggtgct gcggggccac          918
Asp Pro Asp Pro Glu Met Glu His Val                                       
        285                 290                                           

gggggctccc tggagtcggg tcctggcagt ggggactgcc tggtgaacac agatgtgctt      978

gggatgacgg gtgcctccca agagcttccc atctccctag aagagcccaa gcgtccccgt     1038

cccgtggagt cgctaaagcc agccctccct gtcctttcca gaggccctgc cgagagcccg     1098

tgctgcctgc tggagccgcc tgcagacgcg gtcctcggcc ccacgtgaac caggctcggc     1158

ggcgaagccc agccttggag acacccagga ggaaggccgt gctcctggct ccctcctcgg     1218

cccgtcccca cttcccgggg cctcggggca cacagctggg gctgccccca cccgaaagac     1278

cctccacgct cgtcctctac agagtccggc ttcgggaagt gccgggtgct cctgggccct     1338

gcctggctcc ctacgacctt tgggctcgag gccagctcct ccccatgccc gctgtcccag     1398

ctccttgaga ctggagagca gccagcaggt gcccggcagc tcggcgccac ggcttgctga     1458

cagctgggag ggtttctcgg tctggaggcg tagttttgaa actcacatca cccactgtgc     1518

agcgtgagga cgggactctg gtctgctgtg gggggcatgc aggacggcgc cactctctgc     1578

cctgccatgc ggctggtggt gccacagagc ctcaccgtgc ctgagtggca tgcccaggag     1638

gccgctctcc ttcagtaaat gtaacacagt cgaggcacgt catcgggcag ccttccctgt     1698

gtgccaacgc cagccttcgc ttctgaaaac caaactccag ccgctgccag tcgggacttg     1758

gtcgcccggc gctgccagaa tgctccactg ccagccggcc cccctgcctc ggtttccctt     1818

ctgtttagtg gcgacacagg cacccagctt tggggtggtg ctgacgctcc caggggtgcc     1878

aggagccact gggacagggt gaggctccca gacgctcctc gaggtgccca gctctccagg     1938

gagcttctgg cccaaggccg tctgagggat ctgctcctta accccccagt gccttggcga     1998

gggcaggttc caagccacag acgcctgccc cgagtggact ctgcggccag tccctggtgc     2058

cctcctggcc ctgctgccca gtgagggctc ctacgggtgg gttcattggc ctgggcccag     2118

cgagccccca cctgcattga ccttaggccc atagagaggg cctgtcccgg tgctgcccca     2178

gccaggatct ggtcgctgcc ccagggggac tgatgggcag agtcgcccct gtggctggac     2238

tgtgaccatc cctgatgggg cctgaccgcg ggagctgagg aagcgccgct ccaccgtctg     2298

ccctccaagg acccgcatgg aggcagtggg ctggcagctt cctgctgctc cctgtcagag     2358

tcaaagcaca aatcctcagg acgggctcaa gggccagggc agccgaggga agctccaggt     2418

ggggaccacg tcttcctgag gttggtgccc actggctggg accctttgca gtggggtggc     2478

ctcccctctg tctgcctggt ggagggagcc gtgggcgtgg ggacgtgact gaataaagcc     2538

accatgggtg gatgtgcttg g                                               2559


<210>  12
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Arg Lys Arg Trp Glu Cys Pro Ala Leu Pro Gln Gly Trp Glu 
1               5                   10                  15      


Arg Glu Glu Val Pro Arg Arg Ser Gly Leu Ser Ala Gly His Arg Asp 
            20                  25                  30          


Val Phe Tyr Tyr Ser Pro Ser Gly Lys Lys Phe Arg Ser Lys Pro Gln 
        35                  40                  45              


Leu Ala Arg Tyr Leu Gly Gly Ser Met Asp Leu Ser Thr Phe Asp Phe 
    50                  55                  60                  


Arg Thr Gly Lys Met Leu Met Ser Lys Met Asn Lys Ser Arg Gln Arg 
65                  70                  75                  80  


Val Arg Tyr Asp Ser Ser Asn Gln Val Lys Gly Lys Pro Asp Leu Asn 
                85                  90                  95      


Thr Ala Leu Pro Val Arg Gln Thr Ala Ser Ile Phe Lys Gln Pro Val 
            100                 105                 110         


Thr Lys Ile Thr Asn His Pro Ser Asn Lys Val Lys Ser Asp Pro Gln 
        115                 120                 125             


Lys Ala Val Asp Gln Pro Arg Gln Leu Phe Trp Glu Lys Lys Leu Ser 
    130                 135                 140                 


Gly Leu Asn Ala Phe Asp Ile Ala Glu Glu Leu Val Lys Thr Met Asp 
145                 150                 155                 160 


Leu Pro Lys Gly Leu Gln Gly Val Gly Pro Gly Cys Thr Asp Glu Thr 
                165                 170                 175     


Leu Leu Ser Ala Ile Ala Ser Ala Leu His Thr Ser Thr Met Pro Ile 
            180                 185                 190         


Thr Gly Gln Leu Ser Ala Ala Val Glu Lys Asn Pro Gly Val Trp Leu 
        195                 200                 205             


Asn Thr Thr Gln Pro Leu Cys Lys Ala Phe Met Val Thr Asp Glu Asp 
    210                 215                 220                 


Ile Arg Lys Gln Glu Glu Leu Val Gln Gln Val Arg Lys Arg Leu Glu 
225                 230                 235                 240 


Glu Ala Leu Met Ala Asp Met Leu Ala His Val Glu Glu Leu Ala Arg 
                245                 250                 255     


Asp Gly Glu Ala Pro Leu Asp Lys Ala Cys Ala Glu Asp Asp Asp Glu 
            260                 265                 270         


Glu Asp Glu Glu Glu Glu Glu Glu Glu Pro Asp Pro Asp Pro Glu Met 
        275                 280                 285             


Glu His Val 
    290     


<210>  13
<211>  4449
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (191)..(4066)

<400>  13
ggcactaaag gtttgcttcc gggcgtttct tttgcttccc cttccctctt tcacgcttcc       60

tcccctcccc ctcctccctt atcccttcgc tttcgctctt ttccgtcgag gccgacccct      120

gagttgtgag tctggggtct ggttggtgaa aaagagccct tgaagctgga agacgggaga      180

ggacaaaagc atg tct tcc ctt cct ggg tgc att ggt ttg gat gca gca         229
           Met Ser Ser Leu Pro Gly Cys Ile Gly Leu Asp Ala Ala            
           1               5                   10                         

aca gct aca gtg gag tct gaa gag att gca gag ctg caa cag gca gtg        277
Thr Ala Thr Val Glu Ser Glu Glu Ile Ala Glu Leu Gln Gln Ala Val           
    15                  20                  25                            

gtt gag gaa ctg ggt atc tct atg gag gaa ctt cgg cat ttc atc gat        325
Val Glu Glu Leu Gly Ile Ser Met Glu Glu Leu Arg His Phe Ile Asp           
30                  35                  40                  45            

gag gaa ctg gag aag atg gat tgt gta cag caa cgc aag aag cag cta        373
Glu Glu Leu Glu Lys Met Asp Cys Val Gln Gln Arg Lys Lys Gln Leu           
                50                  55                  60                

gca gag tta gag aca tgg gta ata cag aaa gaa tct gag gtg gct cac        421
Ala Glu Leu Glu Thr Trp Val Ile Gln Lys Glu Ser Glu Val Ala His           
            65                  70                  75                    

gtt gac caa ctc ttt gat gat gca tcc agg gca gtg act aat tgt gag        469
Val Asp Gln Leu Phe Asp Asp Ala Ser Arg Ala Val Thr Asn Cys Glu           
        80                  85                  90                        

tct ttg gtg aag gac ttc tac tcc aag ctg gga cta caa tac cgg gac        517
Ser Leu Val Lys Asp Phe Tyr Ser Lys Leu Gly Leu Gln Tyr Arg Asp           
    95                  100                 105                           

agt agc tct gag gac gaa tct tcc cgg cct aca gaa ata att gag att        565
Ser Ser Ser Glu Asp Glu Ser Ser Arg Pro Thr Glu Ile Ile Glu Ile           
110                 115                 120                 125           

cct gat gaa gat gat gat gtc ctc agt att gat tca ggt gat gct ggg        613
Pro Asp Glu Asp Asp Asp Val Leu Ser Ile Asp Ser Gly Asp Ala Gly           
                130                 135                 140               

agc aga act cca aaa gac cag aag ctc cgt gaa gct atg gct gcc tta        661
Ser Arg Thr Pro Lys Asp Gln Lys Leu Arg Glu Ala Met Ala Ala Leu           
            145                 150                 155                   

aga aag tca gct caa gat gtt cag aag ttc atg gat gct gtc aac aag        709
Arg Lys Ser Ala Gln Asp Val Gln Lys Phe Met Asp Ala Val Asn Lys           
        160                 165                 170                       

aag agc agt tcc cag gat ctg cat aaa gga acc ttg agt cag atg tct        757
Lys Ser Ser Ser Gln Asp Leu His Lys Gly Thr Leu Ser Gln Met Ser           
    175                 180                 185                           

gga gaa cta agc aaa gat ggt gac ctg ata gtc agc atg cga att ctg        805
Gly Glu Leu Ser Lys Asp Gly Asp Leu Ile Val Ser Met Arg Ile Leu           
190                 195                 200                 205           

ggc aag aag aga act aag act tgg cac aaa ggc acc ctt att gcc atc        853
Gly Lys Lys Arg Thr Lys Thr Trp His Lys Gly Thr Leu Ile Ala Ile           
                210                 215                 220               

cag aca gtt ggg cca ggg aag aaa tac aag gtg aaa ttt gac aac aaa        901
Gln Thr Val Gly Pro Gly Lys Lys Tyr Lys Val Lys Phe Asp Asn Lys           
            225                 230                 235                   

gga aag agt cta ctg tcg ggg aac cat att gcc tat gat tac cac cct        949
Gly Lys Ser Leu Leu Ser Gly Asn His Ile Ala Tyr Asp Tyr His Pro           
        240                 245                 250                       

cct gct gac aag ctg tat gtg ggc agt cgg gtg gtc gcc aaa tac aaa        997
Pro Ala Asp Lys Leu Tyr Val Gly Ser Arg Val Val Ala Lys Tyr Lys           
    255                 260                 265                           

gat ggg aat cag gtc tgg ctc tat gct ggc att gta gct gag aca cca       1045
Asp Gly Asn Gln Val Trp Leu Tyr Ala Gly Ile Val Ala Glu Thr Pro           
270                 275                 280                 285           

aac gtc aaa aac aag ctc agg ttt ctc att ttc ttt gat gat ggc tat       1093
Asn Val Lys Asn Lys Leu Arg Phe Leu Ile Phe Phe Asp Asp Gly Tyr           
                290                 295                 300               

gct tcc tat gtc aca cag tcg gaa ctg tat ccc att tgc cgg cca ctg       1141
Ala Ser Tyr Val Thr Gln Ser Glu Leu Tyr Pro Ile Cys Arg Pro Leu           
            305                 310                 315                   

aaa aag act tgg gag gac ata gaa gac atc tcc tgc cgt gac ttc ata       1189
Lys Lys Thr Trp Glu Asp Ile Glu Asp Ile Ser Cys Arg Asp Phe Ile           
        320                 325                 330                       

gag gag tat gtc act gcc tac ccc aac cgc ccc atg gta ctg ctc aag       1237
Glu Glu Tyr Val Thr Ala Tyr Pro Asn Arg Pro Met Val Leu Leu Lys           
    335                 340                 345                           

agt ggc cag ctt atc aag act gag tgg gaa ggc acg tgg tgg aag tcc       1285
Ser Gly Gln Leu Ile Lys Thr Glu Trp Glu Gly Thr Trp Trp Lys Ser           
350                 355                 360                 365           

cga gtt gag gag gtg gat ggc agc cta gtc agg atc ctc ttc ctg gat       1333
Arg Val Glu Glu Val Asp Gly Ser Leu Val Arg Ile Leu Phe Leu Asp           
                370                 375                 380               

gac aaa aga tgt gag tgg atc tat cga ggc tct aca cgg ctg gag ccc       1381
Asp Lys Arg Cys Glu Trp Ile Tyr Arg Gly Ser Thr Arg Leu Glu Pro           
            385                 390                 395                   

atg ttc agc atg aaa aca tcc tca gcc tct gca ctg gag aag aag caa       1429
Met Phe Ser Met Lys Thr Ser Ser Ala Ser Ala Leu Glu Lys Lys Gln           
        400                 405                 410                       

gga cag ctc agg aca cgt cca aat atg ggt gct gtg agg agc aaa ggc       1477
Gly Gln Leu Arg Thr Arg Pro Asn Met Gly Ala Val Arg Ser Lys Gly           
    415                 420                 425                           

cct gtt gtc cag tac aca cag gat ctg acc ggt act gga acc cag ttc       1525
Pro Val Val Gln Tyr Thr Gln Asp Leu Thr Gly Thr Gly Thr Gln Phe           
430                 435                 440                 445           

aag cca gtg gaa ccc cca cag cct aca gct cca cct gcc cca cct ttc       1573
Lys Pro Val Glu Pro Pro Gln Pro Thr Ala Pro Pro Ala Pro Pro Phe           
                450                 455                 460               

cca cct gct cca cct cta tcc ccc caa gca ggt gac agt gac ttg gaa       1621
Pro Pro Ala Pro Pro Leu Ser Pro Gln Ala Gly Asp Ser Asp Leu Glu           
            465                 470                 475                   

agc cag ctt gcc cag tca cgg aag cag gta gcc aaa aag agc acg tcc       1669
Ser Gln Leu Ala Gln Ser Arg Lys Gln Val Ala Lys Lys Ser Thr Ser           
        480                 485                 490                       

ttt cga cca gga tct gtg ggc tct ggt cat tcc tcc cct aca tct cct       1717
Phe Arg Pro Gly Ser Val Gly Ser Gly His Ser Ser Pro Thr Ser Pro           
    495                 500                 505                           

gca ctc agt gaa aat gtc tct ggt ggg aaa cct ggg atc aac cag aca       1765
Ala Leu Ser Glu Asn Val Ser Gly Gly Lys Pro Gly Ile Asn Gln Thr           
510                 515                 520                 525           

tat aga tca cct tta ggc tcc aca gcc tct gcc cca gca ccc tca gca       1813
Tyr Arg Ser Pro Leu Gly Ser Thr Ala Ser Ala Pro Ala Pro Ser Ala           
                530                 535                 540               

ctc ccg gcc cct cca gca ccc cca gtc ttc cat ggc atg ctg gag cgg       1861
Leu Pro Ala Pro Pro Ala Pro Pro Val Phe His Gly Met Leu Glu Arg           
            545                 550                 555                   

gcc cca gca gag ccc tcc tac cgt gct ccc atg gag aag ctt ttc tac       1909
Ala Pro Ala Glu Pro Ser Tyr Arg Ala Pro Met Glu Lys Leu Phe Tyr           
        560                 565                 570                       

tta cct cat gtc tgc agc tat acc tgt ctg tct cga gtc aga cct atg       1957
Leu Pro His Val Cys Ser Tyr Thr Cys Leu Ser Arg Val Arg Pro Met           
    575                 580                 585                           

agg aat gag cag tac cgg ggc aag aac cct ctg ctg gtc ccg tta cta       2005
Arg Asn Glu Gln Tyr Arg Gly Lys Asn Pro Leu Leu Val Pro Leu Leu           
590                 595                 600                 605           

tat gac ttc cgg cgg atg aca gcc cgg cgt cga gtt aac cgc aag atg       2053
Tyr Asp Phe Arg Arg Met Thr Ala Arg Arg Arg Val Asn Arg Lys Met           
                610                 615                 620               

ggc ttt cat gtt atc tat aag aca cct tgt ggt ctc tgc ctt cgg aca       2101
Gly Phe His Val Ile Tyr Lys Thr Pro Cys Gly Leu Cys Leu Arg Thr           
            625                 630                 635                   

atg cag gag ata gaa cgc tac ctt ttc gag act ggc tgt gac ttc ctc       2149
Met Gln Glu Ile Glu Arg Tyr Leu Phe Glu Thr Gly Cys Asp Phe Leu           
        640                 645                 650                       

ttc ctg gag atg ttc tgt ttg gat cca tat gtt ctt gtg gac cga aag       2197
Phe Leu Glu Met Phe Cys Leu Asp Pro Tyr Val Leu Val Asp Arg Lys           
    655                 660                 665                           

ttt cag ccc tat aag cct ttt tac tat att ttg gac atc act tat ggg       2245
Phe Gln Pro Tyr Lys Pro Phe Tyr Tyr Ile Leu Asp Ile Thr Tyr Gly           
670                 675                 680                 685           

aag gaa gat gtt ccc cta tcc tgt gtc aat gag att gac aca acc cct       2293
Lys Glu Asp Val Pro Leu Ser Cys Val Asn Glu Ile Asp Thr Thr Pro           
                690                 695                 700               

cca ccc cag gtg gcc tac agc aag gaa cgt atc ccg ggc aag ggt gtt       2341
Pro Pro Gln Val Ala Tyr Ser Lys Glu Arg Ile Pro Gly Lys Gly Val           
            705                 710                 715                   

ttc att aac aca ggc cct gaa ttt ctg gtt ggc tgt gac tgc aag gat       2389
Phe Ile Asn Thr Gly Pro Glu Phe Leu Val Gly Cys Asp Cys Lys Asp           
        720                 725                 730                       

ggg tgt cgg gac aag tcc aag tgt gcc tgc cat caa cta act atc cag       2437
Gly Cys Arg Asp Lys Ser Lys Cys Ala Cys His Gln Leu Thr Ile Gln           
    735                 740                 745                           

gct aca gcc tgt acc cca gga ggc caa atc aac cct aac tct ggc tac       2485
Ala Thr Ala Cys Thr Pro Gly Gly Gln Ile Asn Pro Asn Ser Gly Tyr           
750                 755                 760                 765           

cag tac aag aga cta gaa gag tgt cta ccc aca ggg gta tat gag tgt       2533
Gln Tyr Lys Arg Leu Glu Glu Cys Leu Pro Thr Gly Val Tyr Glu Cys           
                770                 775                 780               

aac aaa cgc tgc aaa tgt gac cca aac atg tgc aca aac cgg ttg gtg       2581
Asn Lys Arg Cys Lys Cys Asp Pro Asn Met Cys Thr Asn Arg Leu Val           
            785                 790                 795                   

caa cat gga cta caa gtt cgg cta cag cta ttc aag aca cag aac aag       2629
Gln His Gly Leu Gln Val Arg Leu Gln Leu Phe Lys Thr Gln Asn Lys           
        800                 805                 810                       

ggc tgg ggt atc cgc tgc ttg gat gac att gcc aaa ggc tct ttt gtt       2677
Gly Trp Gly Ile Arg Cys Leu Asp Asp Ile Ala Lys Gly Ser Phe Val           
    815                 820                 825                           

tgt att tat gca ggc aaa atc ctg aca gat gac ttt gca gac aag gag       2725
Cys Ile Tyr Ala Gly Lys Ile Leu Thr Asp Asp Phe Ala Asp Lys Glu           
830                 835                 840                 845           

ggt ctg gaa atg ggt gat gag tac ttt gca aat ctg gac cat atc gag       2773
Gly Leu Glu Met Gly Asp Glu Tyr Phe Ala Asn Leu Asp His Ile Glu           
                850                 855                 860               

agc gtg gag aac ttc aaa gaa gga tat gag agt gat gcc ccc tgt tcc       2821
Ser Val Glu Asn Phe Lys Glu Gly Tyr Glu Ser Asp Ala Pro Cys Ser           
            865                 870                 875                   

tct gac agc agt ggt gta gac ttg aag gac cag gaa gat ggc aac agc       2869
Ser Asp Ser Ser Gly Val Asp Leu Lys Asp Gln Glu Asp Gly Asn Ser           
        880                 885                 890                       

ggt aca gag gac cct gaa gag tcc aat gat gat agc tca gat gat aac       2917
Gly Thr Glu Asp Pro Glu Glu Ser Asn Asp Asp Ser Ser Asp Asp Asn           
    895                 900                 905                           

ttc tgt aag gat gag gac ttc agc acc agt tca gtg tgg cgg agc tat       2965
Phe Cys Lys Asp Glu Asp Phe Ser Thr Ser Ser Val Trp Arg Ser Tyr           
910                 915                 920                 925           

gct acc cgg agg cag acc cgg ggc cag aaa gag aac gga ctc tct gag       3013
Ala Thr Arg Arg Gln Thr Arg Gly Gln Lys Glu Asn Gly Leu Ser Glu           
                930                 935                 940               

aca act tcc aag gac tcc cac ccc cca gat ctt gga ccc cca cat att       3061
Thr Thr Ser Lys Asp Ser His Pro Pro Asp Leu Gly Pro Pro His Ile           
            945                 950                 955                   

cct gtt cct ccc tca atc cct gta ggt ggc tgc aat cca cct tcc tcc       3109
Pro Val Pro Pro Ser Ile Pro Val Gly Gly Cys Asn Pro Pro Ser Ser           
        960                 965                 970                       

gaa gag aca ccc aag aac aag gtg gcc tca tgg ttg agc tgc aat agt       3157
Glu Glu Thr Pro Lys Asn Lys Val Ala Ser Trp Leu Ser Cys Asn Ser           
    975                 980                 985                           

gtc agt gaa ggt ggt ttt gct gac tct gat agc  cat tca tcc ttc aag      3205
Val Ser Glu Gly Gly Phe Ala Asp Ser Asp Ser  His Ser Ser Phe Lys          
990                 995                 1000                 1005         

act aat gaa ggt ggg  gag ggc cgg gct ggg  gga agc cga atg gag         3250
Thr Asn Glu Gly Gly  Glu Gly Arg Ala Gly  Gly Ser Arg Met Glu             
                1010                 1015                 1020            

gct gag aag gcc tcc  acc tca gga cta ggc  atc aag gat gag gga         3295
Ala Glu Lys Ala Ser  Thr Ser Gly Leu Gly  Ile Lys Asp Glu Gly             
                1025                 1030                 1035            

gac atc aaa cag gcc  aag aaa gag gac act  gac gac cga aac aag         3340
Asp Ile Lys Gln Ala  Lys Lys Glu Asp Thr  Asp Asp Arg Asn Lys             
                1040                 1045                 1050            

atg tca gta gtt act  gaa agc tct cga aat  tac ggt tac aat cct         3385
Met Ser Val Val Thr  Glu Ser Ser Arg Asn  Tyr Gly Tyr Asn Pro             
                1055                 1060                 1065            

tct cct gtg aag cct  gaa gga ctt cgc cgc  cca cct agt aag act         3430
Ser Pro Val Lys Pro  Glu Gly Leu Arg Arg  Pro Pro Ser Lys Thr             
                1070                 1075                 1080            

agt atg cat caa agc  cga aga ctc atg gct  tct gct cag tcc aac         3475
Ser Met His Gln Ser  Arg Arg Leu Met Ala  Ser Ala Gln Ser Asn             
                1085                 1090                 1095            

cct gat gat gtc ctg  aca ctg tcc agc agc  aca gaa agt gag ggg         3520
Pro Asp Asp Val Leu  Thr Leu Ser Ser Ser  Thr Glu Ser Glu Gly             
                1100                 1105                 1110            

gaa agt ggg acc agc  cga aag ccc act gct  ggt cag act tcg gct         3565
Glu Ser Gly Thr Ser  Arg Lys Pro Thr Ala  Gly Gln Thr Ser Ala             
                1115                 1120                 1125            

aca gcg gtt gac agt  gat gat atc cag acc  ata tcc tct ggc tct         3610
Thr Ala Val Asp Ser  Asp Asp Ile Gln Thr  Ile Ser Ser Gly Ser             
                1130                 1135                 1140            

gaa ggg gat gac ttt  gag gac aag aag aac  atg act ggt cca atg         3655
Glu Gly Asp Asp Phe  Glu Asp Lys Lys Asn  Met Thr Gly Pro Met             
                1145                 1150                 1155            

aag cgt caa gtg gca  gta aaa tca acc cga  ggc ttt gct ctt aaa         3700
Lys Arg Gln Val Ala  Val Lys Ser Thr Arg  Gly Phe Ala Leu Lys             
                1160                 1165                 1170            

tca acc cat ggg att  gca att aaa tca acc  aac atg gcc tct gtg         3745
Ser Thr His Gly Ile  Ala Ile Lys Ser Thr  Asn Met Ala Ser Val             
                1175                 1180                 1185            

gac aag ggg gag agc  gca cct gtt cgt aag  aac aca cgc caa ttc         3790
Asp Lys Gly Glu Ser  Ala Pro Val Arg Lys  Asn Thr Arg Gln Phe             
                1190                 1195                 1200            

tat gat ggc gag gag  tct tgc tac atc att  gat gcc aag ctt gaa         3835
Tyr Asp Gly Glu Glu  Ser Cys Tyr Ile Ile  Asp Ala Lys Leu Glu             
                1205                 1210                 1215            

ggc aac ctg ggc cgc  tac ctc aac cac agt  tgc agc ccc aac ctg         3880
Gly Asn Leu Gly Arg  Tyr Leu Asn His Ser  Cys Ser Pro Asn Leu             
                1220                 1225                 1230            

ttt gtc cag aat gtc  ttc gtg gat acc cat  gat ctt cgc ttc ccc         3925
Phe Val Gln Asn Val  Phe Val Asp Thr His  Asp Leu Arg Phe Pro             
                1235                 1240                 1245            

tgg gtg gcc ttc ttt  gcc agc aaa aga atc  cgg gct ggg aca gaa         3970
Trp Val Ala Phe Phe  Ala Ser Lys Arg Ile  Arg Ala Gly Thr Glu             
                1250                 1255                 1260            

ctt act tgg gac tac  aac tac gag gtg ggc  agt gtg gaa ggc aag         4015
Leu Thr Trp Asp Tyr  Asn Tyr Glu Val Gly  Ser Val Glu Gly Lys             
                1265                 1270                 1275            

gag cta ctc tgt tgc  tgt ggg gcc att gaa  tgc aga gga cgt ctt         4060
Glu Leu Leu Cys Cys  Cys Gly Ala Ile Glu  Cys Arg Gly Arg Leu             
                1280                 1285                 1290            

ctt tag aggacagcct tcttcccaac ccttcttgaa ctgtcgtttc ctcaggaact        4116
Leu                                                                       
                                                                          

gggtcttcct gattgttgaa ccctgacccg aagtctctgg gctagctact ccccccagct     4176

cctagttgat agaaatgggg gttctggacc agatgatccc ttccaatgtg gtgctagcag     4236

gcaggatccc ttctccacct ccaaaggccc taaagggtgg ggagagatca ccactctaac     4296

ctcggcctga catccctccc atcccatatt tgtccaagtg ttcctgcttc taacagactt     4356

tgttcttaga atggagcctg tgtatctact atctccagtt tgtattattt cttgaaagtc     4416

ttttaacaat atgataaaac taagattgtg aaa                                  4449


<210>  14
<211>  1291
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Ser Leu Pro Gly Cys Ile Gly Leu Asp Ala Ala Thr Ala Thr 
1               5                   10                  15      


Val Glu Ser Glu Glu Ile Ala Glu Leu Gln Gln Ala Val Val Glu Glu 
            20                  25                  30          


Leu Gly Ile Ser Met Glu Glu Leu Arg His Phe Ile Asp Glu Glu Leu 
        35                  40                  45              


Glu Lys Met Asp Cys Val Gln Gln Arg Lys Lys Gln Leu Ala Glu Leu 
    50                  55                  60                  


Glu Thr Trp Val Ile Gln Lys Glu Ser Glu Val Ala His Val Asp Gln 
65                  70                  75                  80  


Leu Phe Asp Asp Ala Ser Arg Ala Val Thr Asn Cys Glu Ser Leu Val 
                85                  90                  95      


Lys Asp Phe Tyr Ser Lys Leu Gly Leu Gln Tyr Arg Asp Ser Ser Ser 
            100                 105                 110         


Glu Asp Glu Ser Ser Arg Pro Thr Glu Ile Ile Glu Ile Pro Asp Glu 
        115                 120                 125             


Asp Asp Asp Val Leu Ser Ile Asp Ser Gly Asp Ala Gly Ser Arg Thr 
    130                 135                 140                 


Pro Lys Asp Gln Lys Leu Arg Glu Ala Met Ala Ala Leu Arg Lys Ser 
145                 150                 155                 160 


Ala Gln Asp Val Gln Lys Phe Met Asp Ala Val Asn Lys Lys Ser Ser 
                165                 170                 175     


Ser Gln Asp Leu His Lys Gly Thr Leu Ser Gln Met Ser Gly Glu Leu 
            180                 185                 190         


Ser Lys Asp Gly Asp Leu Ile Val Ser Met Arg Ile Leu Gly Lys Lys 
        195                 200                 205             


Arg Thr Lys Thr Trp His Lys Gly Thr Leu Ile Ala Ile Gln Thr Val 
    210                 215                 220                 


Gly Pro Gly Lys Lys Tyr Lys Val Lys Phe Asp Asn Lys Gly Lys Ser 
225                 230                 235                 240 


Leu Leu Ser Gly Asn His Ile Ala Tyr Asp Tyr His Pro Pro Ala Asp 
                245                 250                 255     


Lys Leu Tyr Val Gly Ser Arg Val Val Ala Lys Tyr Lys Asp Gly Asn 
            260                 265                 270         


Gln Val Trp Leu Tyr Ala Gly Ile Val Ala Glu Thr Pro Asn Val Lys 
        275                 280                 285             


Asn Lys Leu Arg Phe Leu Ile Phe Phe Asp Asp Gly Tyr Ala Ser Tyr 
    290                 295                 300                 


Val Thr Gln Ser Glu Leu Tyr Pro Ile Cys Arg Pro Leu Lys Lys Thr 
305                 310                 315                 320 


Trp Glu Asp Ile Glu Asp Ile Ser Cys Arg Asp Phe Ile Glu Glu Tyr 
                325                 330                 335     


Val Thr Ala Tyr Pro Asn Arg Pro Met Val Leu Leu Lys Ser Gly Gln 
            340                 345                 350         


Leu Ile Lys Thr Glu Trp Glu Gly Thr Trp Trp Lys Ser Arg Val Glu 
        355                 360                 365             


Glu Val Asp Gly Ser Leu Val Arg Ile Leu Phe Leu Asp Asp Lys Arg 
    370                 375                 380                 


Cys Glu Trp Ile Tyr Arg Gly Ser Thr Arg Leu Glu Pro Met Phe Ser 
385                 390                 395                 400 


Met Lys Thr Ser Ser Ala Ser Ala Leu Glu Lys Lys Gln Gly Gln Leu 
                405                 410                 415     


Arg Thr Arg Pro Asn Met Gly Ala Val Arg Ser Lys Gly Pro Val Val 
            420                 425                 430         


Gln Tyr Thr Gln Asp Leu Thr Gly Thr Gly Thr Gln Phe Lys Pro Val 
        435                 440                 445             


Glu Pro Pro Gln Pro Thr Ala Pro Pro Ala Pro Pro Phe Pro Pro Ala 
    450                 455                 460                 


Pro Pro Leu Ser Pro Gln Ala Gly Asp Ser Asp Leu Glu Ser Gln Leu 
465                 470                 475                 480 


Ala Gln Ser Arg Lys Gln Val Ala Lys Lys Ser Thr Ser Phe Arg Pro 
                485                 490                 495     


Gly Ser Val Gly Ser Gly His Ser Ser Pro Thr Ser Pro Ala Leu Ser 
            500                 505                 510         


Glu Asn Val Ser Gly Gly Lys Pro Gly Ile Asn Gln Thr Tyr Arg Ser 
        515                 520                 525             


Pro Leu Gly Ser Thr Ala Ser Ala Pro Ala Pro Ser Ala Leu Pro Ala 
    530                 535                 540                 


Pro Pro Ala Pro Pro Val Phe His Gly Met Leu Glu Arg Ala Pro Ala 
545                 550                 555                 560 


Glu Pro Ser Tyr Arg Ala Pro Met Glu Lys Leu Phe Tyr Leu Pro His 
                565                 570                 575     


Val Cys Ser Tyr Thr Cys Leu Ser Arg Val Arg Pro Met Arg Asn Glu 
            580                 585                 590         


Gln Tyr Arg Gly Lys Asn Pro Leu Leu Val Pro Leu Leu Tyr Asp Phe 
        595                 600                 605             


Arg Arg Met Thr Ala Arg Arg Arg Val Asn Arg Lys Met Gly Phe His 
    610                 615                 620                 


Val Ile Tyr Lys Thr Pro Cys Gly Leu Cys Leu Arg Thr Met Gln Glu 
625                 630                 635                 640 


Ile Glu Arg Tyr Leu Phe Glu Thr Gly Cys Asp Phe Leu Phe Leu Glu 
                645                 650                 655     


Met Phe Cys Leu Asp Pro Tyr Val Leu Val Asp Arg Lys Phe Gln Pro 
            660                 665                 670         


Tyr Lys Pro Phe Tyr Tyr Ile Leu Asp Ile Thr Tyr Gly Lys Glu Asp 
        675                 680                 685             


Val Pro Leu Ser Cys Val Asn Glu Ile Asp Thr Thr Pro Pro Pro Gln 
    690                 695                 700                 


Val Ala Tyr Ser Lys Glu Arg Ile Pro Gly Lys Gly Val Phe Ile Asn 
705                 710                 715                 720 


Thr Gly Pro Glu Phe Leu Val Gly Cys Asp Cys Lys Asp Gly Cys Arg 
                725                 730                 735     


Asp Lys Ser Lys Cys Ala Cys His Gln Leu Thr Ile Gln Ala Thr Ala 
            740                 745                 750         


Cys Thr Pro Gly Gly Gln Ile Asn Pro Asn Ser Gly Tyr Gln Tyr Lys 
        755                 760                 765             


Arg Leu Glu Glu Cys Leu Pro Thr Gly Val Tyr Glu Cys Asn Lys Arg 
    770                 775                 780                 


Cys Lys Cys Asp Pro Asn Met Cys Thr Asn Arg Leu Val Gln His Gly 
785                 790                 795                 800 


Leu Gln Val Arg Leu Gln Leu Phe Lys Thr Gln Asn Lys Gly Trp Gly 
                805                 810                 815     


Ile Arg Cys Leu Asp Asp Ile Ala Lys Gly Ser Phe Val Cys Ile Tyr 
            820                 825                 830         


Ala Gly Lys Ile Leu Thr Asp Asp Phe Ala Asp Lys Glu Gly Leu Glu 
        835                 840                 845             


Met Gly Asp Glu Tyr Phe Ala Asn Leu Asp His Ile Glu Ser Val Glu 
    850                 855                 860                 


Asn Phe Lys Glu Gly Tyr Glu Ser Asp Ala Pro Cys Ser Ser Asp Ser 
865                 870                 875                 880 


Ser Gly Val Asp Leu Lys Asp Gln Glu Asp Gly Asn Ser Gly Thr Glu 
                885                 890                 895     


Asp Pro Glu Glu Ser Asn Asp Asp Ser Ser Asp Asp Asn Phe Cys Lys 
            900                 905                 910         


Asp Glu Asp Phe Ser Thr Ser Ser Val Trp Arg Ser Tyr Ala Thr Arg 
        915                 920                 925             


Arg Gln Thr Arg Gly Gln Lys Glu Asn Gly Leu Ser Glu Thr Thr Ser 
    930                 935                 940                 


Lys Asp Ser His Pro Pro Asp Leu Gly Pro Pro His Ile Pro Val Pro 
945                 950                 955                 960 


Pro Ser Ile Pro Val Gly Gly Cys Asn Pro Pro Ser Ser Glu Glu Thr 
                965                 970                 975     


Pro Lys Asn Lys Val Ala Ser Trp Leu Ser Cys Asn Ser Val Ser Glu 
            980                 985                 990         


Gly Gly Phe Ala Asp Ser Asp Ser  His Ser Ser Phe Lys  Thr Asn Glu 
        995                 1000                 1005             


Gly Gly  Glu Gly Arg Ala Gly  Gly Ser Arg Met Glu  Ala Glu Lys 
    1010                 1015                 1020             


Ala Ser  Thr Ser Gly Leu Gly  Ile Lys Asp Glu Gly  Asp Ile Lys 
    1025                 1030                 1035             


Gln Ala  Lys Lys Glu Asp Thr  Asp Asp Arg Asn Lys  Met Ser Val 
    1040                 1045                 1050             


Val Thr  Glu Ser Ser Arg Asn  Tyr Gly Tyr Asn Pro  Ser Pro Val 
    1055                 1060                 1065             


Lys Pro  Glu Gly Leu Arg Arg  Pro Pro Ser Lys Thr  Ser Met His 
    1070                 1075                 1080             


Gln Ser  Arg Arg Leu Met Ala  Ser Ala Gln Ser Asn  Pro Asp Asp 
    1085                 1090                 1095             


Val Leu  Thr Leu Ser Ser Ser  Thr Glu Ser Glu Gly  Glu Ser Gly 
    1100                 1105                 1110             


Thr Ser  Arg Lys Pro Thr Ala  Gly Gln Thr Ser Ala  Thr Ala Val 
    1115                 1120                 1125             


Asp Ser  Asp Asp Ile Gln Thr  Ile Ser Ser Gly Ser  Glu Gly Asp 
    1130                 1135                 1140             


Asp Phe  Glu Asp Lys Lys Asn  Met Thr Gly Pro Met  Lys Arg Gln 
    1145                 1150                 1155             


Val Ala  Val Lys Ser Thr Arg  Gly Phe Ala Leu Lys  Ser Thr His 
    1160                 1165                 1170             


Gly Ile  Ala Ile Lys Ser Thr  Asn Met Ala Ser Val  Asp Lys Gly 
    1175                 1180                 1185             


Glu Ser  Ala Pro Val Arg Lys  Asn Thr Arg Gln Phe  Tyr Asp Gly 
    1190                 1195                 1200             


Glu Glu  Ser Cys Tyr Ile Ile  Asp Ala Lys Leu Glu  Gly Asn Leu 
    1205                 1210                 1215             


Gly Arg  Tyr Leu Asn His Ser  Cys Ser Pro Asn Leu  Phe Val Gln 
    1220                 1225                 1230             


Asn Val  Phe Val Asp Thr His  Asp Leu Arg Phe Pro  Trp Val Ala 
    1235                 1240                 1245             


Phe Phe  Ala Ser Lys Arg Ile  Arg Ala Gly Thr Glu  Leu Thr Trp 
    1250                 1255                 1260             


Asp Tyr  Asn Tyr Glu Val Gly  Ser Val Glu Gly Lys  Glu Leu Leu 
    1265                 1270                 1275             


Cys Cys  Cys Gly Ala Ile Glu  Cys Arg Gly Arg Leu  Leu 
    1280                 1285                 1290     


<210>  15
<211>  4395
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (339)..(3077)

<400>  15
gcagtgggct ctggcggagg tcgggagaac tgcagggcga aggccgccgg gggctccgcg       60

ggctgcgggg ggaggcactt gacaccggcc cggggagagg aggggccgct gtccctgcgg      120

ccagtgctgg atgcggggac ccagcgcaga agcagcgcca ggtggagcca tcgaagcccc      180

cacccacagg ctgacagagg caccgttcac cagagggctc aacaccggga tctatgttta      240

agttttaact ctcgcctcca aagaccacga taattccttc cccaaagccc agcagccccc      300

cagccccgcg cagccccagc ctgcctcccg gcgcccag atg ccc gcc atg ccc tcc      356
                                          Met Pro Ala Met Pro Ser         
                                          1               5               

agc ggc ccc ggg gac acc agc agc tct gct gcg gag cgg gag gag gac        404
Ser Gly Pro Gly Asp Thr Ser Ser Ser Ala Ala Glu Arg Glu Glu Asp           
            10                  15                  20                    

cga aag gac gga gag gag cag gag gag ccg cgt ggc aag gag gag cgc        452
Arg Lys Asp Gly Glu Glu Gln Glu Glu Pro Arg Gly Lys Glu Glu Arg           
        25                  30                  35                        

caa gag ccc agc acc acg gca cgg aag gtg ggg cgg cct ggg agg aag        500
Gln Glu Pro Ser Thr Thr Ala Arg Lys Val Gly Arg Pro Gly Arg Lys           
    40                  45                  50                            

cgc aag cac ccc ccg gtg gaa agc ggt gac acg cca aag gac cct gcg        548
Arg Lys His Pro Pro Val Glu Ser Gly Asp Thr Pro Lys Asp Pro Ala           
55                  60                  65                  70            

gtg atc tcc aag tcc cca tcc atg gcc cag gac tca ggc gcc tca gag        596
Val Ile Ser Lys Ser Pro Ser Met Ala Gln Asp Ser Gly Ala Ser Glu           
                75                  80                  85                

cta tta ccc aat ggg gac ttg gag aag cgg agt gag ccc cag cca gag        644
Leu Leu Pro Asn Gly Asp Leu Glu Lys Arg Ser Glu Pro Gln Pro Glu           
            90                  95                  100                   

gag ggg agc cct gct ggg ggg cag aag ggc ggg gcc cca gca gag gga        692
Glu Gly Ser Pro Ala Gly Gly Gln Lys Gly Gly Ala Pro Ala Glu Gly           
        105                 110                 115                       

gag ggt gca gct gag acc ctg cct gaa gcc tca aga gca gtg gaa aat        740
Glu Gly Ala Ala Glu Thr Leu Pro Glu Ala Ser Arg Ala Val Glu Asn           
    120                 125                 130                           

ggc tgc tgc acc ccc aag gag ggc cga gga gcc cct gca gaa gcg ggc        788
Gly Cys Cys Thr Pro Lys Glu Gly Arg Gly Ala Pro Ala Glu Ala Gly           
135                 140                 145                 150           

aaa gaa cag aag gag acc aac atc gaa tcc atg aaa atg gag ggc tcc        836
Lys Glu Gln Lys Glu Thr Asn Ile Glu Ser Met Lys Met Glu Gly Ser           
                155                 160                 165               

cgg ggc cgg ctg cgg ggt ggc ttg ggc tgg gag tcc agc ctc cgt cag        884
Arg Gly Arg Leu Arg Gly Gly Leu Gly Trp Glu Ser Ser Leu Arg Gln           
            170                 175                 180                   

cgg ccc atg ccg agg ctc acc ttc cag gcg ggg gac ccc tac tac atc        932
Arg Pro Met Pro Arg Leu Thr Phe Gln Ala Gly Asp Pro Tyr Tyr Ile           
        185                 190                 195                       

agc aag cgc aag cgg gac gag tgg ctg gca cgc tgg aaa agg gag gct        980
Ser Lys Arg Lys Arg Asp Glu Trp Leu Ala Arg Trp Lys Arg Glu Ala           
    200                 205                 210                           

gag aag aaa gcc aag gtc att gca gga atg aat gct gtg gaa gaa aac       1028
Glu Lys Lys Ala Lys Val Ile Ala Gly Met Asn Ala Val Glu Glu Asn           
215                 220                 225                 230           

cag ggg ccc ggg gag tct cag aag gtg gag gag gcc agc cct cct gct       1076
Gln Gly Pro Gly Glu Ser Gln Lys Val Glu Glu Ala Ser Pro Pro Ala           
                235                 240                 245               

gtg cag cag ccc act gac ccc gca tcc ccc act gtg gct acc acg cct       1124
Val Gln Gln Pro Thr Asp Pro Ala Ser Pro Thr Val Ala Thr Thr Pro           
            250                 255                 260                   

gag ccc gtg ggg tcc gat gct ggg gac aag aat gcc acc aaa gca ggc       1172
Glu Pro Val Gly Ser Asp Ala Gly Asp Lys Asn Ala Thr Lys Ala Gly           
        265                 270                 275                       

gat gac gag cca gag tac gag gac ggc cgg ggc ttt ggc att ggg gag       1220
Asp Asp Glu Pro Glu Tyr Glu Asp Gly Arg Gly Phe Gly Ile Gly Glu           
    280                 285                 290                           

ctg gtg tgg ggg aaa ctg cgg ggc ttc tcc tgg tgg cca ggc cgc att       1268
Leu Val Trp Gly Lys Leu Arg Gly Phe Ser Trp Trp Pro Gly Arg Ile           
295                 300                 305                 310           

gtg tct tgg tgg atg acg ggc cgg agc cga gca gct gaa ggc acc cgc       1316
Val Ser Trp Trp Met Thr Gly Arg Ser Arg Ala Ala Glu Gly Thr Arg           
                315                 320                 325               

tgg gtc atg tgg ttc gga gac ggc aaa ttc tca gtg gtg tgt gtt gag       1364
Trp Val Met Trp Phe Gly Asp Gly Lys Phe Ser Val Val Cys Val Glu           
            330                 335                 340                   

aag ctg atg ccg ctg agc tcg ttt tgc agt gcg ttc cac cag gcc acg       1412
Lys Leu Met Pro Leu Ser Ser Phe Cys Ser Ala Phe His Gln Ala Thr           
        345                 350                 355                       

tac aac aag cag ccc atg tac cgc aaa gcc atc tac gag gtc ctg cag       1460
Tyr Asn Lys Gln Pro Met Tyr Arg Lys Ala Ile Tyr Glu Val Leu Gln           
    360                 365                 370                           

gtg gcc agc agc cgc gcg ggg aag ctg ttc ccg gtg tgc cac gac agc       1508
Val Ala Ser Ser Arg Ala Gly Lys Leu Phe Pro Val Cys His Asp Ser           
375                 380                 385                 390           

gat gag agt gac act gcc aag gcc gtg gag gtg cag aac aag ccc atg       1556
Asp Glu Ser Asp Thr Ala Lys Ala Val Glu Val Gln Asn Lys Pro Met           
                395                 400                 405               

att gaa tgg gcc ctg ggg ggc ttc cag cct tct ggc cct aag ggc ctg       1604
Ile Glu Trp Ala Leu Gly Gly Phe Gln Pro Ser Gly Pro Lys Gly Leu           
            410                 415                 420                   

gag cca cca gaa gaa gag aag aat ccc tac aaa gaa gtg tac acg gac       1652
Glu Pro Pro Glu Glu Glu Lys Asn Pro Tyr Lys Glu Val Tyr Thr Asp           
        425                 430                 435                       

atg tgg gtg gaa cct gag gca gct gcc tac gca cca cct cca cca gcc       1700
Met Trp Val Glu Pro Glu Ala Ala Ala Tyr Ala Pro Pro Pro Pro Ala           
    440                 445                 450                           

aaa aag ccc cgg aag agc aca gcg gag aag ccc aag gtc aag gag att       1748
Lys Lys Pro Arg Lys Ser Thr Ala Glu Lys Pro Lys Val Lys Glu Ile           
455                 460                 465                 470           

att gat gag cgc aca aga gag cgg ctg gtg tac gag gtg cgg cag aag       1796
Ile Asp Glu Arg Thr Arg Glu Arg Leu Val Tyr Glu Val Arg Gln Lys           
                475                 480                 485               

tgc cgg aac att gag gac atc tgc atc tcc tgt ggg agc ctc aat gtt       1844
Cys Arg Asn Ile Glu Asp Ile Cys Ile Ser Cys Gly Ser Leu Asn Val           
            490                 495                 500                   

acc ctg gaa cac ccc ctc ttc gtt gga gga atg tgc caa aac tgc aag       1892
Thr Leu Glu His Pro Leu Phe Val Gly Gly Met Cys Gln Asn Cys Lys           
        505                 510                 515                       

aac tgc ttt ctg gag tgt gcg tac cag tac gac gac gac ggc tac cag       1940
Asn Cys Phe Leu Glu Cys Ala Tyr Gln Tyr Asp Asp Asp Gly Tyr Gln           
    520                 525                 530                           

tcc tac tgc acc atc tgc tgt ggg ggc cgt gag gtg ctc atg tgc gga       1988
Ser Tyr Cys Thr Ile Cys Cys Gly Gly Arg Glu Val Leu Met Cys Gly           
535                 540                 545                 550           

aac aac aac tgc tgc agg tgc ttt tgc gtg gag tgt gtg gac ctc ttg       2036
Asn Asn Asn Cys Cys Arg Cys Phe Cys Val Glu Cys Val Asp Leu Leu           
                555                 560                 565               

gtg ggg ccg ggg gct gcc cag gca gcc att aag gaa gac ccc tgg aac       2084
Val Gly Pro Gly Ala Ala Gln Ala Ala Ile Lys Glu Asp Pro Trp Asn           
            570                 575                 580                   

tgc tac atg tgc ggg cac aag ggt acc tac ggg ctg ctg cgg cgg cga       2132
Cys Tyr Met Cys Gly His Lys Gly Thr Tyr Gly Leu Leu Arg Arg Arg           
        585                 590                 595                       

gag gac tgg ccc tcc cgg ctc cag atg ttc ttc gct aat aac cac gac       2180
Glu Asp Trp Pro Ser Arg Leu Gln Met Phe Phe Ala Asn Asn His Asp           
    600                 605                 610                           

cag gaa ttt gac cct cca aag gtt tac cca cct gtc cca gct gag aag       2228
Gln Glu Phe Asp Pro Pro Lys Val Tyr Pro Pro Val Pro Ala Glu Lys           
615                 620                 625                 630           

agg aag ccc atc cgg gtg ctg tct ctc ttt gat gga atc gct aca ggg       2276
Arg Lys Pro Ile Arg Val Leu Ser Leu Phe Asp Gly Ile Ala Thr Gly           
                635                 640                 645               

ctc ctg gtg ctg aag gac ttg ggc att cag gtg gac cgc tac att gcc       2324
Leu Leu Val Leu Lys Asp Leu Gly Ile Gln Val Asp Arg Tyr Ile Ala           
            650                 655                 660                   

tcg gag gtg tgt gag gac tcc atc acg gtg ggc atg gtg cgg cac cag       2372
Ser Glu Val Cys Glu Asp Ser Ile Thr Val Gly Met Val Arg His Gln           
        665                 670                 675                       

ggg aag atc atg tac gtc ggg gac gtc cgc agc gtc aca cag aag cat       2420
Gly Lys Ile Met Tyr Val Gly Asp Val Arg Ser Val Thr Gln Lys His           
    680                 685                 690                           

atc cag gag tgg ggc cca ttc gat ctg gtg att ggg ggc agt ccc tgc       2468
Ile Gln Glu Trp Gly Pro Phe Asp Leu Val Ile Gly Gly Ser Pro Cys           
695                 700                 705                 710           

aat gac ctc tcc atc gtc aac cct gct cgc aag ggc ctc tac gag ggc       2516
Asn Asp Leu Ser Ile Val Asn Pro Ala Arg Lys Gly Leu Tyr Glu Gly           
                715                 720                 725               

act ggc cgg ctc ttc ttt gag ttc tac cgc ctc ctg cat gat gcg cgg       2564
Thr Gly Arg Leu Phe Phe Glu Phe Tyr Arg Leu Leu His Asp Ala Arg           
            730                 735                 740                   

ccc aag gag gga gat gat cgc ccc ttc ttc tgg ctc ttt gag aat gtg       2612
Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe Trp Leu Phe Glu Asn Val           
        745                 750                 755                       

gtg gcc atg ggc gtt agt gac aag agg gac atc tcg cga ttt ctc gag       2660
Val Ala Met Gly Val Ser Asp Lys Arg Asp Ile Ser Arg Phe Leu Glu           
    760                 765                 770                           

tcc aac cct gtg atg att gat gcc aaa gaa gtg tca gct gca cac agg       2708
Ser Asn Pro Val Met Ile Asp Ala Lys Glu Val Ser Ala Ala His Arg           
775                 780                 785                 790           

gcc cgc tac ttc tgg ggt aac ctt ccc ggt atg aac agg ccg ttg gca       2756
Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly Met Asn Arg Pro Leu Ala           
                795                 800                 805               

tcc act gtg aat gat aag ctg gag ctg cag gag tgt ctg gag cat ggc       2804
Ser Thr Val Asn Asp Lys Leu Glu Leu Gln Glu Cys Leu Glu His Gly           
            810                 815                 820                   

agg ata gcc aag ttc agc aaa gtg agg acc att act acg agg tca aac       2852
Arg Ile Ala Lys Phe Ser Lys Val Arg Thr Ile Thr Thr Arg Ser Asn           
        825                 830                 835                       

tcc ata aag cag ggc aaa gac cag cat ttt cct gtc ttc atg aat gag       2900
Ser Ile Lys Gln Gly Lys Asp Gln His Phe Pro Val Phe Met Asn Glu           
    840                 845                 850                           

aaa gag gac atc tta tgg tgc act gaa atg gaa agg gta ttt ggt ttc       2948
Lys Glu Asp Ile Leu Trp Cys Thr Glu Met Glu Arg Val Phe Gly Phe           
855                 860                 865                 870           

cca gtc cac tat act gac gtc tcc aac atg agc cgc ttg gcg agg cag       2996
Pro Val His Tyr Thr Asp Val Ser Asn Met Ser Arg Leu Ala Arg Gln           
                875                 880                 885               

aga ctg ctg ggc cgg tca tgg agc gtg cca gtc atc cgc cac ctc ttc       3044
Arg Leu Leu Gly Arg Ser Trp Ser Val Pro Val Ile Arg His Leu Phe           
            890                 895                 900                   

gct ccg ctg aag gag tat ttt gcg tgt gtg taa gggacatggg ggcaaactga     3097
Ala Pro Leu Lys Glu Tyr Phe Ala Cys Val                                   
        905                 910                                           

ggtagcgaca caaagttaaa caaacaaaca aaaaacacaa aacataataa aacaccaaga     3157

acatgaggat ggagagaagt atcagcaccc agaagagaaa aaggaattta aaacaaaaac     3217

cacagaggcg gaaataccgg agggctttgc cttgcgaaaa gggttggaca tcatctcctg     3277

atttttcaat gttattcttc agtcctattt aaaaacaaaa ccaagctccc ttcccttcct     3337

cccccttccc ttttttttcg gtcagacctt ttattttcta ctcttttcag aggggttttc     3397

tgtttgtttg ggttttgttt cttgctgtga ctgaaacaag aaggttattg cagcaaaaat     3457

cagtaacaaa aaatagtaac aataccttgc agaggaaagg tgggagagag gaaaaaagga     3517

aattctatag aaatctatat attgggttgt tttttttttt gttttttgtt tttttttttt     3577

gggttttttt ttttactata tatctttttt ttgttgtctc tagcctgatc agataggagc     3637

acaagcaggg gacggaaaga gagagacact caggcggcag cattccctcc cagccactga     3697

gctgtcgtgc cagcaccatt cctggtcacg caaaacagaa cccagttagc agcagggaga     3757

cgagaacacc acacaagaca tttttctaca gtatttcagg tgcctaccac acaggaaacc     3817

ttgaagaaaa tcagtttcta gaagccgctg ttacctcttg tttacagttt atatatatat     3877

gatagatatg agatatatat ataaaaggta ctgttaacta ctgtacaacc cgacttcata     3937

atggtgcttt caaacagcga gatgagtaaa aacatcagct tccacgttgc cttctgcgca     3997

aagggtttca ccaaggatgg agaaagggag acagcttgca gatggcgcgt tctcacggtg     4057

ggctcttccc cttggtttgt aacgaagtga aggaggagaa cttgggagcc aggttctccc     4117

tgccaaaaag ggggctagat gaggtggtcg ggcccgtgga cagctgagag tgggattcat     4177

ccagactcat gcaataaccc tttgattgtt ttctaaaagg agactccctc ggcaagatgg     4237

cagagggtac ggagtcttca ggcccagttt ctcactttag ccaattcgag ggctccttgt     4297

ggtgggatca gaactaatcc agagtgtggg aaagtgacag tcaaaacccc acctggagca     4357

aataaaaaaa catacaaaac gtaaaaaaaa aaaaaaaa                             4395


<210>  16
<211>  912
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Pro Ala Met Pro Ser Ser Gly Pro Gly Asp Thr Ser Ser Ser Ala 
1               5                   10                  15      


Ala Glu Arg Glu Glu Asp Arg Lys Asp Gly Glu Glu Gln Glu Glu Pro 
            20                  25                  30          


Arg Gly Lys Glu Glu Arg Gln Glu Pro Ser Thr Thr Ala Arg Lys Val 
        35                  40                  45              


Gly Arg Pro Gly Arg Lys Arg Lys His Pro Pro Val Glu Ser Gly Asp 
    50                  55                  60                  


Thr Pro Lys Asp Pro Ala Val Ile Ser Lys Ser Pro Ser Met Ala Gln 
65                  70                  75                  80  


Asp Ser Gly Ala Ser Glu Leu Leu Pro Asn Gly Asp Leu Glu Lys Arg 
                85                  90                  95      


Ser Glu Pro Gln Pro Glu Glu Gly Ser Pro Ala Gly Gly Gln Lys Gly 
            100                 105                 110         


Gly Ala Pro Ala Glu Gly Glu Gly Ala Ala Glu Thr Leu Pro Glu Ala 
        115                 120                 125             


Ser Arg Ala Val Glu Asn Gly Cys Cys Thr Pro Lys Glu Gly Arg Gly 
    130                 135                 140                 


Ala Pro Ala Glu Ala Gly Lys Glu Gln Lys Glu Thr Asn Ile Glu Ser 
145                 150                 155                 160 


Met Lys Met Glu Gly Ser Arg Gly Arg Leu Arg Gly Gly Leu Gly Trp 
                165                 170                 175     


Glu Ser Ser Leu Arg Gln Arg Pro Met Pro Arg Leu Thr Phe Gln Ala 
            180                 185                 190         


Gly Asp Pro Tyr Tyr Ile Ser Lys Arg Lys Arg Asp Glu Trp Leu Ala 
        195                 200                 205             


Arg Trp Lys Arg Glu Ala Glu Lys Lys Ala Lys Val Ile Ala Gly Met 
    210                 215                 220                 


Asn Ala Val Glu Glu Asn Gln Gly Pro Gly Glu Ser Gln Lys Val Glu 
225                 230                 235                 240 


Glu Ala Ser Pro Pro Ala Val Gln Gln Pro Thr Asp Pro Ala Ser Pro 
                245                 250                 255     


Thr Val Ala Thr Thr Pro Glu Pro Val Gly Ser Asp Ala Gly Asp Lys 
            260                 265                 270         


Asn Ala Thr Lys Ala Gly Asp Asp Glu Pro Glu Tyr Glu Asp Gly Arg 
        275                 280                 285             


Gly Phe Gly Ile Gly Glu Leu Val Trp Gly Lys Leu Arg Gly Phe Ser 
    290                 295                 300                 


Trp Trp Pro Gly Arg Ile Val Ser Trp Trp Met Thr Gly Arg Ser Arg 
305                 310                 315                 320 


Ala Ala Glu Gly Thr Arg Trp Val Met Trp Phe Gly Asp Gly Lys Phe 
                325                 330                 335     


Ser Val Val Cys Val Glu Lys Leu Met Pro Leu Ser Ser Phe Cys Ser 
            340                 345                 350         


Ala Phe His Gln Ala Thr Tyr Asn Lys Gln Pro Met Tyr Arg Lys Ala 
        355                 360                 365             


Ile Tyr Glu Val Leu Gln Val Ala Ser Ser Arg Ala Gly Lys Leu Phe 
    370                 375                 380                 


Pro Val Cys His Asp Ser Asp Glu Ser Asp Thr Ala Lys Ala Val Glu 
385                 390                 395                 400 


Val Gln Asn Lys Pro Met Ile Glu Trp Ala Leu Gly Gly Phe Gln Pro 
                405                 410                 415     


Ser Gly Pro Lys Gly Leu Glu Pro Pro Glu Glu Glu Lys Asn Pro Tyr 
            420                 425                 430         


Lys Glu Val Tyr Thr Asp Met Trp Val Glu Pro Glu Ala Ala Ala Tyr 
        435                 440                 445             


Ala Pro Pro Pro Pro Ala Lys Lys Pro Arg Lys Ser Thr Ala Glu Lys 
    450                 455                 460                 


Pro Lys Val Lys Glu Ile Ile Asp Glu Arg Thr Arg Glu Arg Leu Val 
465                 470                 475                 480 


Tyr Glu Val Arg Gln Lys Cys Arg Asn Ile Glu Asp Ile Cys Ile Ser 
                485                 490                 495     


Cys Gly Ser Leu Asn Val Thr Leu Glu His Pro Leu Phe Val Gly Gly 
            500                 505                 510         


Met Cys Gln Asn Cys Lys Asn Cys Phe Leu Glu Cys Ala Tyr Gln Tyr 
        515                 520                 525             


Asp Asp Asp Gly Tyr Gln Ser Tyr Cys Thr Ile Cys Cys Gly Gly Arg 
    530                 535                 540                 


Glu Val Leu Met Cys Gly Asn Asn Asn Cys Cys Arg Cys Phe Cys Val 
545                 550                 555                 560 


Glu Cys Val Asp Leu Leu Val Gly Pro Gly Ala Ala Gln Ala Ala Ile 
                565                 570                 575     


Lys Glu Asp Pro Trp Asn Cys Tyr Met Cys Gly His Lys Gly Thr Tyr 
            580                 585                 590         


Gly Leu Leu Arg Arg Arg Glu Asp Trp Pro Ser Arg Leu Gln Met Phe 
        595                 600                 605             


Phe Ala Asn Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr Pro 
    610                 615                 620                 


Pro Val Pro Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser Leu Phe 
625                 630                 635                 640 


Asp Gly Ile Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly Ile Gln 
                645                 650                 655     


Val Asp Arg Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile Thr Val 
            660                 665                 670         


Gly Met Val Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp Val Arg 
        675                 680                 685             


Ser Val Thr Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp Leu Val 
    690                 695                 700                 


Ile Gly Gly Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro Ala Arg 
705                 710                 715                 720 


Lys Gly Leu Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr Arg 
                725                 730                 735     


Leu Leu His Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe 
            740                 745                 750         


Trp Leu Phe Glu Asn Val Val Ala Met Gly Val Ser Asp Lys Arg Asp 
        755                 760                 765             


Ile Ser Arg Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala Lys Glu 
    770                 775                 780                 


Val Ser Ala Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly 
785                 790                 795                 800 


Met Asn Arg Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu Leu Gln 
                805                 810                 815     


Glu Cys Leu Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val Arg Thr 
            820                 825                 830         


Ile Thr Thr Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln His Phe 
        835                 840                 845             


Pro Val Phe Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu Met 
    850                 855                 860                 


Glu Arg Val Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn Met 
865                 870                 875                 880 


Ser Arg Leu Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser Val Pro 
                885                 890                 895     


Val Ile Arg His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys Val 
            900                 905                 910         


<210>  17
<211>  1744
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (195)..(1415)

<400>  17
cagcgcccgg gccatggcgg cggcggtggc gggagctgct gtctgagcag cggttgcgga       60

ccgagcgaac ttggcccagg agcccgggcc tagggagagg cgcggcggcg gcgggagcgc      120

gaacggctgg agctggcctt cttcgccttc tcctcggctg tggagccctg gtggggggtc      180

tgcgcccggt cacc atg acg acg ccg gcg aat gcc cag aat gcc agc aaa        230
                Met Thr Thr Pro Ala Asn Ala Gln Asn Ala Ser Lys           
                1               5                   10                    

acg tgg gaa ctg agt ctg tat gag ctg cac cgg acc ccg cag gaa gcc        278
Thr Trp Glu Leu Ser Leu Tyr Glu Leu His Arg Thr Pro Gln Glu Ala           
        15                  20                  25                        

ata atg gat ggc aca gag att gct gtt tcc cct cgg tca ctg cat tca        326
Ile Met Asp Gly Thr Glu Ile Ala Val Ser Pro Arg Ser Leu His Ser           
    30                  35                  40                            

gaa ctc atg tgc cct atc tgc ctg gac atg ctg aag aat acg atg acc        374
Glu Leu Met Cys Pro Ile Cys Leu Asp Met Leu Lys Asn Thr Met Thr           
45                  50                  55                  60            

acc aag gag tgc ctc cac aga ttc tgc tct gac tgc att gtc aca gcc        422
Thr Lys Glu Cys Leu His Arg Phe Cys Ser Asp Cys Ile Val Thr Ala           
                65                  70                  75                

cta cgg agc ggg aac aag gag tgt cct acc tgc cga aag aag ctg gtg        470
Leu Arg Ser Gly Asn Lys Glu Cys Pro Thr Cys Arg Lys Lys Leu Val           
            80                  85                  90                    

tcc aag cga tcc cta cgg cca gac ccc aac ttt gat gcc ctg atc tct        518
Ser Lys Arg Ser Leu Arg Pro Asp Pro Asn Phe Asp Ala Leu Ile Ser           
        95                  100                 105                       

aag atc tat cct agc cgg gag gaa tac gag gcc cat caa gac cga gtg        566
Lys Ile Tyr Pro Ser Arg Glu Glu Tyr Glu Ala His Gln Asp Arg Val           
    110                 115                 120                           

ctt atc cgc ctg agc cgc ctg cac aac cag cag gca ttg agc tcc agc        614
Leu Ile Arg Leu Ser Arg Leu His Asn Gln Gln Ala Leu Ser Ser Ser           
125                 130                 135                 140           

att gag gag ggg cta cgc atg cag gcc atg cac agg gcc cag cgt gtg        662
Ile Glu Glu Gly Leu Arg Met Gln Ala Met His Arg Ala Gln Arg Val           
                145                 150                 155               

agg cgg ccg ata cca ggg tca gat cag acc aca acg atg agt ggg ggg        710
Arg Arg Pro Ile Pro Gly Ser Asp Gln Thr Thr Thr Met Ser Gly Gly           
            160                 165                 170                   

gaa gga gag ccc ggg gag gga gaa ggg gat gga gaa gat gtg agc tca        758
Glu Gly Glu Pro Gly Glu Gly Glu Gly Asp Gly Glu Asp Val Ser Ser           
        175                 180                 185                       

gac tcc gcc cct gac tct gcc cca ggc cct gct ccc aag cga ccc cgt        806
Asp Ser Ala Pro Asp Ser Ala Pro Gly Pro Ala Pro Lys Arg Pro Arg           
    190                 195                 200                           

gga ggg ggc gca ggg ggg agc agt gta ggg aca ggg gga ggc ggc act        854
Gly Gly Gly Ala Gly Gly Ser Ser Val Gly Thr Gly Gly Gly Gly Thr           
205                 210                 215                 220           

ggt ggg gtg ggt ggg ggt gcc ggt tcg gaa gac tct ggt gac cgg gga        902
Gly Gly Val Gly Gly Gly Ala Gly Ser Glu Asp Ser Gly Asp Arg Gly           
                225                 230                 235               

ggg act ctg gga ggg gga acg ctg ggc ccc cca agc cct cct ggg gcc        950
Gly Thr Leu Gly Gly Gly Thr Leu Gly Pro Pro Ser Pro Pro Gly Ala           
            240                 245                 250                   

ccc agc ccc cca gag cca ggt gga gaa att gag ctc gtg ttc cgg ccc        998
Pro Ser Pro Pro Glu Pro Gly Gly Glu Ile Glu Leu Val Phe Arg Pro           
        255                 260                 265                       

cac ccc ctg ctc gtg gag aag gga gaa tac tgc cag acg agg tat gtg       1046
His Pro Leu Leu Val Glu Lys Gly Glu Tyr Cys Gln Thr Arg Tyr Val           
    270                 275                 280                           

aag aca act ggg aat gcc aca gtg gac cac ctc tcc aag tac ttg gcc       1094
Lys Thr Thr Gly Asn Ala Thr Val Asp His Leu Ser Lys Tyr Leu Ala           
285                 290                 295                 300           

ctg cgc att gcc ctc gag cgg agg caa cag cag gaa gca ggg gag cca       1142
Leu Arg Ile Ala Leu Glu Arg Arg Gln Gln Gln Glu Ala Gly Glu Pro           
                305                 310                 315               

gga ggg cct gga ggg ggc gcc tct gac acc gga gga cct gat ggg tgt       1190
Gly Gly Pro Gly Gly Gly Ala Ser Asp Thr Gly Gly Pro Asp Gly Cys           
            320                 325                 330                   

ggc ggg gag ggt ggg ggt gcc gga gga ggt gac ggt cct gag gag cct       1238
Gly Gly Glu Gly Gly Gly Ala Gly Gly Gly Asp Gly Pro Glu Glu Pro           
        335                 340                 345                       

gct ttg ccc agc ctg gag ggc gtc agt gaa aag cag tac acc atc tac       1286
Ala Leu Pro Ser Leu Glu Gly Val Ser Glu Lys Gln Tyr Thr Ile Tyr           
    350                 355                 360                           

atc gca cct gga ggc ggg gcg ttc acg acg ttg aat ggc tcg ctg acc       1334
Ile Ala Pro Gly Gly Gly Ala Phe Thr Thr Leu Asn Gly Ser Leu Thr           
365                 370                 375                 380           

ctg gag ctg gtg aat gag aaa ttc tgg aag gtg tcc cgg cca ctg gag       1382
Leu Glu Leu Val Asn Glu Lys Phe Trp Lys Val Ser Arg Pro Leu Glu           
                385                 390                 395               

ctg tgc tat gct ccc acc aag gat cca aag tga ccccaccagg ggacagccag     1435
Leu Cys Tyr Ala Pro Thr Lys Asp Pro Lys                                   
            400                 405                                       

aggaagggga ccatggggta tccctgtgtc ctggtctatc accccagctt ctttgtcccc     1495

cagtaccccc agcccagcca gccaataaga ggacacaaat gaggacacgt ggcttttata     1555

caaagtatct atatgagatt cttctatatt gtacagagtg gggcaaaaca cgcccccatc     1615

tgctgccttt tctattgccc tgcaacgtcc catctatacg aggtgttgga gaaggtgaag     1675

aaccctccca ttcacgcccg cctaccaaca acaaacgtgc ttttttcctc tttgaaacct     1735

gcaaaaaaa                                                             1744


<210>  18
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Thr Pro Ala Asn Ala Gln Asn Ala Ser Lys Thr Trp Glu Leu 
1               5                   10                  15      


Ser Leu Tyr Glu Leu His Arg Thr Pro Gln Glu Ala Ile Met Asp Gly 
            20                  25                  30          


Thr Glu Ile Ala Val Ser Pro Arg Ser Leu His Ser Glu Leu Met Cys 
        35                  40                  45              


Pro Ile Cys Leu Asp Met Leu Lys Asn Thr Met Thr Thr Lys Glu Cys 
    50                  55                  60                  


Leu His Arg Phe Cys Ser Asp Cys Ile Val Thr Ala Leu Arg Ser Gly 
65                  70                  75                  80  


Asn Lys Glu Cys Pro Thr Cys Arg Lys Lys Leu Val Ser Lys Arg Ser 
                85                  90                  95      


Leu Arg Pro Asp Pro Asn Phe Asp Ala Leu Ile Ser Lys Ile Tyr Pro 
            100                 105                 110         


Ser Arg Glu Glu Tyr Glu Ala His Gln Asp Arg Val Leu Ile Arg Leu 
        115                 120                 125             


Ser Arg Leu His Asn Gln Gln Ala Leu Ser Ser Ser Ile Glu Glu Gly 
    130                 135                 140                 


Leu Arg Met Gln Ala Met His Arg Ala Gln Arg Val Arg Arg Pro Ile 
145                 150                 155                 160 


Pro Gly Ser Asp Gln Thr Thr Thr Met Ser Gly Gly Glu Gly Glu Pro 
                165                 170                 175     


Gly Glu Gly Glu Gly Asp Gly Glu Asp Val Ser Ser Asp Ser Ala Pro 
            180                 185                 190         


Asp Ser Ala Pro Gly Pro Ala Pro Lys Arg Pro Arg Gly Gly Gly Ala 
        195                 200                 205             


Gly Gly Ser Ser Val Gly Thr Gly Gly Gly Gly Thr Gly Gly Val Gly 
    210                 215                 220                 


Gly Gly Ala Gly Ser Glu Asp Ser Gly Asp Arg Gly Gly Thr Leu Gly 
225                 230                 235                 240 


Gly Gly Thr Leu Gly Pro Pro Ser Pro Pro Gly Ala Pro Ser Pro Pro 
                245                 250                 255     


Glu Pro Gly Gly Glu Ile Glu Leu Val Phe Arg Pro His Pro Leu Leu 
            260                 265                 270         


Val Glu Lys Gly Glu Tyr Cys Gln Thr Arg Tyr Val Lys Thr Thr Gly 
        275                 280                 285             


Asn Ala Thr Val Asp His Leu Ser Lys Tyr Leu Ala Leu Arg Ile Ala 
    290                 295                 300                 


Leu Glu Arg Arg Gln Gln Gln Glu Ala Gly Glu Pro Gly Gly Pro Gly 
305                 310                 315                 320 


Gly Gly Ala Ser Asp Thr Gly Gly Pro Asp Gly Cys Gly Gly Glu Gly 
                325                 330                 335     


Gly Gly Ala Gly Gly Gly Asp Gly Pro Glu Glu Pro Ala Leu Pro Ser 
            340                 345                 350         


Leu Glu Gly Val Ser Glu Lys Gln Tyr Thr Ile Tyr Ile Ala Pro Gly 
        355                 360                 365             


Gly Gly Ala Phe Thr Thr Leu Asn Gly Ser Leu Thr Leu Glu Leu Val 
    370                 375                 380                 


Asn Glu Lys Phe Trp Lys Val Ser Arg Pro Leu Glu Leu Cys Tyr Ala 
385                 390                 395                 400 


Pro Thr Lys Asp Pro Lys 
                405     


<210>  19
<211>  3873
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (55)..(2631)

<400>  19
catctgcctg cccttctgcc atccgagcgc cctgactgcg ccacactgca ggcc atg         57
                                                            Met           
                                                            1             

gag aat gag ctg cca gtc cca cat aca tct agc agt gcc tgt gcc acc        105
Glu Asn Glu Leu Pro Val Pro His Thr Ser Ser Ser Ala Cys Ala Thr           
            5                   10                  15                    

agc agt acc agc ggg gcc agt agc agc agt ggc tgc aac aac agc agc        153
Ser Ser Thr Ser Gly Ala Ser Ser Ser Ser Gly Cys Asn Asn Ser Ser           
        20                  25                  30                        

agt ggt gga agt ggc cgc ccc acc ggg ccc cag att tct gtg tac agt        201
Ser Gly Gly Ser Gly Arg Pro Thr Gly Pro Gln Ile Ser Val Tyr Ser           
    35                  40                  45                            

ggt att cca gac cgg cag acc gtg cag gtg atc cag cag gcc ctg cac        249
Gly Ile Pro Asp Arg Gln Thr Val Gln Val Ile Gln Gln Ala Leu His           
50                  55                  60                  65            

aga cag ccc agc acg gcc gct cag tac ctg cag cag atg tac gcc gcc        297
Arg Gln Pro Ser Thr Ala Ala Gln Tyr Leu Gln Gln Met Tyr Ala Ala           
                70                  75                  80                

cag cag cag cac ctc atg ctg cag acc gcg gcg ctc cag cag cag cac        345
Gln Gln Gln His Leu Met Leu Gln Thr Ala Ala Leu Gln Gln Gln His           
            85                  90                  95                    

ctc agc agc gcc cag ctc cag agc ctg gca gcc gta cag cag gca agc        393
Leu Ser Ser Ala Gln Leu Gln Ser Leu Ala Ala Val Gln Gln Ala Ser           
        100                 105                 110                       

ctg gta tcc aat aga caa gga agc act tca ggc agc aat gtg tct gcg        441
Leu Val Ser Asn Arg Gln Gly Ser Thr Ser Gly Ser Asn Val Ser Ala           
    115                 120                 125                           

cag gcc ccg gcc cag tca tct tcg atc aac ctg gca gcc tcc cca gca        489
Gln Ala Pro Ala Gln Ser Ser Ser Ile Asn Leu Ala Ala Ser Pro Ala           
130                 135                 140                 145           

gca gcc cag ctc ctc aac cgg gcc cag agt gtg aac tct gca gca gcc        537
Ala Ala Gln Leu Leu Asn Arg Ala Gln Ser Val Asn Ser Ala Ala Ala           
                150                 155                 160               

tca ggc atc gct cag cag gct gtg ctc ttg ggc aac acg tct tcc cca        585
Ser Gly Ile Ala Gln Gln Ala Val Leu Leu Gly Asn Thr Ser Ser Pro           
            165                 170                 175                   

gcc ctg act gca agc caa gca cag atg tat ctg agg gca cag atg ctc        633
Ala Leu Thr Ala Ser Gln Ala Gln Met Tyr Leu Arg Ala Gln Met Leu           
        180                 185                 190                       

atc ttc acg ccc acg gcc acc gtc gct act gtg cag cct gag ctc ggc        681
Ile Phe Thr Pro Thr Ala Thr Val Ala Thr Val Gln Pro Glu Leu Gly           
    195                 200                 205                           

act ggc tcc ccc gcc cgg ccc ccc acc ccc gcc cag gta cag aac ttg        729
Thr Gly Ser Pro Ala Arg Pro Pro Thr Pro Ala Gln Val Gln Asn Leu           
210                 215                 220                 225           

acc ctc cga aca cag cag aca cca gcg gca gca gcc tcg ggc ccc acc        777
Thr Leu Arg Thr Gln Gln Thr Pro Ala Ala Ala Ala Ser Gly Pro Thr           
                230                 235                 240               

ccc act cag cct gtc ctg ccc agc ttg gcc ctg aaa ccc acg ccg ggc        825
Pro Thr Gln Pro Val Leu Pro Ser Leu Ala Leu Lys Pro Thr Pro Gly           
            245                 250                 255                   

ggt agc cag cct ctg cct acc cca gca cag agc aga aat act gct cag        873
Gly Ser Gln Pro Leu Pro Thr Pro Ala Gln Ser Arg Asn Thr Ala Gln           
        260                 265                 270                       

gct tcc cct gca ggt gcc aag cct ggc ata gct gac agt gtg atg gag        921
Ala Ser Pro Ala Gly Ala Lys Pro Gly Ile Ala Asp Ser Val Met Glu           
    275                 280                 285                           

cca cac aag aaa gga gat ggc aac agc agt gtg cca ggg agc atg gaa        969
Pro His Lys Lys Gly Asp Gly Asn Ser Ser Val Pro Gly Ser Met Glu           
290                 295                 300                 305           

ggc cgg gct ggg ctc agc cgg acg gtt cct gct gtg gct gcc cac ccc       1017
Gly Arg Ala Gly Leu Ser Arg Thr Val Pro Ala Val Ala Ala His Pro           
                310                 315                 320               

ctc att gca cca gcc tat gct cag ctg cag cca cac cag ctc ctc cca       1065
Leu Ile Ala Pro Ala Tyr Ala Gln Leu Gln Pro His Gln Leu Leu Pro           
            325                 330                 335                   

cag cca tcc tca aag cac ctg cag ccc caa ttt gtg atc cag cag cag       1113
Gln Pro Ser Ser Lys His Leu Gln Pro Gln Phe Val Ile Gln Gln Gln           
        340                 345                 350                       

cca cag cca caa cag cag cag ccg ccg ccc cag cag tca cgg cct gtg       1161
Pro Gln Pro Gln Gln Gln Gln Pro Pro Pro Gln Gln Ser Arg Pro Val           
    355                 360                 365                           

ctc caa gct gag ccc cac ccc cag ctc gcc tca gtc tct cca agc gtg       1209
Leu Gln Ala Glu Pro His Pro Gln Leu Ala Ser Val Ser Pro Ser Val           
370                 375                 380                 385           

gcc ctc cag ccc agc tca gag gcc cat gcc atg cca cta ggc ccg gtt       1257
Ala Leu Gln Pro Ser Ser Glu Ala His Ala Met Pro Leu Gly Pro Val           
                390                 395                 400               

aca ccc gcc ctg cca ctc cag tgt ccc act gcc aac ctg cac aag cct       1305
Thr Pro Ala Leu Pro Leu Gln Cys Pro Thr Ala Asn Leu His Lys Pro           
            405                 410                 415                   

ggc ggc agt cag cag tgt cac cct ccc aca cct gat act ggg cct cag       1353
Gly Gly Ser Gln Gln Cys His Pro Pro Thr Pro Asp Thr Gly Pro Gln           
        420                 425                 430                       

aat gga cat ccc gag ggc gtg ccc cac acc cct caa cgc agg ttc cag       1401
Asn Gly His Pro Glu Gly Val Pro His Thr Pro Gln Arg Arg Phe Gln           
    435                 440                 445                           

cac act tca gct gtc atc tta caa ctg cag cct gct tca cca ccc cag       1449
His Thr Ser Ala Val Ile Leu Gln Leu Gln Pro Ala Ser Pro Pro Gln           
450                 455                 460                 465           

cag tgt gtc cct gat gac tgg aaa gaa gtg gca cca ggg gag aaa agt       1497
Gln Cys Val Pro Asp Asp Trp Lys Glu Val Ala Pro Gly Glu Lys Ser           
                470                 475                 480               

gtg cct gag acg cgg tct ggc cca tca cca cat cag cag gct att gtc       1545
Val Pro Glu Thr Arg Ser Gly Pro Ser Pro His Gln Gln Ala Ile Val           
            485                 490                 495                   

act gcc atg cct ggt ggc ctg cct gta ccc acg agc cct aac atc cag       1593
Thr Ala Met Pro Gly Gly Leu Pro Val Pro Thr Ser Pro Asn Ile Gln           
        500                 505                 510                       

ccg tcc cca gct cac gag aca ggg cag ggc att gtt cat gca ctg acc       1641
Pro Ser Pro Ala His Glu Thr Gly Gln Gly Ile Val His Ala Leu Thr           
    515                 520                 525                           

gac ctc agc agc ccc ggc atg acc tca ggg aac gga aac tct gcc tcc       1689
Asp Leu Ser Ser Pro Gly Met Thr Ser Gly Asn Gly Asn Ser Ala Ser           
530                 535                 540                 545           

agc atc gcc ggc act gcc ccc cag aat ggt gag aat aaa cca cca cag       1737
Ser Ile Ala Gly Thr Ala Pro Gln Asn Gly Glu Asn Lys Pro Pro Gln           
                550                 555                 560               

gcc att gtg aaa ccc caa atc ctg acg cat gtt atc gaa ggg ttt gtg       1785
Ala Ile Val Lys Pro Gln Ile Leu Thr His Val Ile Glu Gly Phe Val           
            565                 570                 575                   

atc cag gag ggg gcg gag cct ttc ccg gtg gga cgc tcg tcc ctg ctg       1833
Ile Gln Glu Gly Ala Glu Pro Phe Pro Val Gly Arg Ser Ser Leu Leu           
        580                 585                 590                       

gtg ggg aat ctc aag aag aag tat gca cag ggg ttc ctg cct gag aaa       1881
Val Gly Asn Leu Lys Lys Lys Tyr Ala Gln Gly Phe Leu Pro Glu Lys           
    595                 600                 605                           

ctt cca cag cag gat cac acc acc acc act gac tcg gag atg gag gag       1929
Leu Pro Gln Gln Asp His Thr Thr Thr Thr Asp Ser Glu Met Glu Glu           
610                 615                 620                 625           

ccc tat ctg caa gaa tcc aaa gag gag ggt gct ccc ctc aaa ctc aag       1977
Pro Tyr Leu Gln Glu Ser Lys Glu Glu Gly Ala Pro Leu Lys Leu Lys           
                630                 635                 640               

tgt gag ctc tgt ggc cgg gtg gac ttt gcc tat aag ttc aag cgt tcc       2025
Cys Glu Leu Cys Gly Arg Val Asp Phe Ala Tyr Lys Phe Lys Arg Ser           
            645                 650                 655                   

aag cgc ttc tgt tcc atg gct tgt gca aag agg tac aac gtg gga tgc       2073
Lys Arg Phe Cys Ser Met Ala Cys Ala Lys Arg Tyr Asn Val Gly Cys           
        660                 665                 670                       

acc aaa cgg gtg gga ctt ttc cac tca gac cgg agc aag ctg cag aag       2121
Thr Lys Arg Val Gly Leu Phe His Ser Asp Arg Ser Lys Leu Gln Lys           
    675                 680                 685                           

gca gga gct gcg acc cac aac cgc cgt cgg gcc agc aaa gcc agt ctg       2169
Ala Gly Ala Ala Thr His Asn Arg Arg Arg Ala Ser Lys Ala Ser Leu           
690                 695                 700                 705           

cca cca ctt acc aag gat acc aag aag cag cca aca ggc act gtg ccc       2217
Pro Pro Leu Thr Lys Asp Thr Lys Lys Gln Pro Thr Gly Thr Val Pro           
                710                 715                 720               

ctt tcg gtt act gct gct ttg cag cta aca cac agc cag gaa gac tcc       2265
Leu Ser Val Thr Ala Ala Leu Gln Leu Thr His Ser Gln Glu Asp Ser           
            725                 730                 735                   

agc cgt tgc tca gat aac tca agc tat gag gaa ccc ttg tca ccc atc       2313
Ser Arg Cys Ser Asp Asn Ser Ser Tyr Glu Glu Pro Leu Ser Pro Ile           
        740                 745                 750                       

tca gcc agc tca tct act tcc cgc cgg cga caa ggc cag cgg gac ctg       2361
Ser Ala Ser Ser Ser Thr Ser Arg Arg Arg Gln Gly Gln Arg Asp Leu           
    755                 760                 765                           

gag ctc ccc gac atg cat atg cgg gac ctg gtg ggc atg gga cac cac       2409
Glu Leu Pro Asp Met His Met Arg Asp Leu Val Gly Met Gly His His           
770                 775                 780                 785           

ttc ctg cca agt gag ccc acc aag tgg aat gta gaa gac gtc tac gaa       2457
Phe Leu Pro Ser Glu Pro Thr Lys Trp Asn Val Glu Asp Val Tyr Glu           
                790                 795                 800               

ttc atc cgc tct ctg cca ggc tgc cag gag ata gca gag gaa ttc cgt       2505
Phe Ile Arg Ser Leu Pro Gly Cys Gln Glu Ile Ala Glu Glu Phe Arg           
            805                 810                 815                   

gcc cag gaa atc gac ggg caa gcc ctg ctg ctg ctc aag gag gac cac       2553
Ala Gln Glu Ile Asp Gly Gln Ala Leu Leu Leu Leu Lys Glu Asp His           
        820                 825                 830                       

ctg atg agc gcc atg aac atc aag ctg ggg ccc gcc ctg aag atc tac       2601
Leu Met Ser Ala Met Asn Ile Lys Leu Gly Pro Ala Leu Lys Ile Tyr           
    835                 840                 845                           

gcc cgc atc agc atg ctc aag gac tcc tag ggctggtggc agccaggatt         2651
Ala Arg Ile Ser Met Leu Lys Asp Ser                                       
850                 855                                                   

ctggcccagg gcgcctcctc ccgactgagc agagccagac agacattcct gaggggccca     2711

gaaatggggc cggttggagg gcaggggctc tccctagggg catagctggt gaggaggtct     2771

gggcacctcc tccatggctc tcaggggcct ttcatttctg tgggaggggc agagaggtag     2831

gtggcacaga agatggggct ttatgcttgt aaatattgat agcactggct tcctccaaag     2891

tcccaatact ctagccccgc tctcttcccc tctttctgtc ccccattttc cagggggtat     2951

atggtcaggg ctccccaacc tgagttgggt tacttcaagg gcagccagca ggcctggatg     3011

gaggcctaga aagcccttgc cttccttcct cccacttctt tctccaggcc tggttaactc     3071

ttccgttgtc agcttctccc ccttcagcct gtttctgcag cagccagggt tctcccccct     3131

acaccctctg caggtggaga gagagaagct gggcccagcc gggccgtgcc tgctggcaca     3191

gacgccttaa cgctgtgtgt atgactgtgt gactgtgtgg gagcctggac tgacagatag     3251

gccaagggct actctctggc atctccaggt gttttgtagc aaacagccac ttagtgcttt     3311

gtcctggact ccactcagcc tcaggatggg gaatagccaa gaatggcagc ctcagcgcag     3371

aggcaaggtc agaaagagac ggcgcttcag agtttccttt ccagacaccc ctccccgcac     3431

tgtgaagttc ccctgaccgc cctcctggtt cacaaagagc attaagaaag ctgcggtggt     3491

ctgagcaaca tagcccaaag ggctgagcct cctggcctgc ctgcccgccc accctgggag     3551

tcccagtggt gaggctcaga gaactgctaa ggggaaagaa cagctggagt ttctgttgat     3611

gtgaagaagg cagctcttgg cctcccactc ccacacttct ttgcctataa atcttcctag     3671

cagcaatttg agctacctga ggaggaggca gggcagaaag ggcgagggcc tgcctctgac     3731

ctgccgtgtc ctttgcagga aggaggtagg cacctttctg agcttattct attccccacc     3791

cacaccccca ggcagggttg gaaatgaagg acttttttaa cctttgtttt gttttttaaa     3851

aataaatctg taaaatctgt ct                                              3873


<210>  20
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Asn Glu Leu Pro Val Pro His Thr Ser Ser Ser Ala Cys Ala 
1               5                   10                  15      


Thr Ser Ser Thr Ser Gly Ala Ser Ser Ser Ser Gly Cys Asn Asn Ser 
            20                  25                  30          


Ser Ser Gly Gly Ser Gly Arg Pro Thr Gly Pro Gln Ile Ser Val Tyr 
        35                  40                  45              


Ser Gly Ile Pro Asp Arg Gln Thr Val Gln Val Ile Gln Gln Ala Leu 
    50                  55                  60                  


His Arg Gln Pro Ser Thr Ala Ala Gln Tyr Leu Gln Gln Met Tyr Ala 
65                  70                  75                  80  


Ala Gln Gln Gln His Leu Met Leu Gln Thr Ala Ala Leu Gln Gln Gln 
                85                  90                  95      


His Leu Ser Ser Ala Gln Leu Gln Ser Leu Ala Ala Val Gln Gln Ala 
            100                 105                 110         


Ser Leu Val Ser Asn Arg Gln Gly Ser Thr Ser Gly Ser Asn Val Ser 
        115                 120                 125             


Ala Gln Ala Pro Ala Gln Ser Ser Ser Ile Asn Leu Ala Ala Ser Pro 
    130                 135                 140                 


Ala Ala Ala Gln Leu Leu Asn Arg Ala Gln Ser Val Asn Ser Ala Ala 
145                 150                 155                 160 


Ala Ser Gly Ile Ala Gln Gln Ala Val Leu Leu Gly Asn Thr Ser Ser 
                165                 170                 175     


Pro Ala Leu Thr Ala Ser Gln Ala Gln Met Tyr Leu Arg Ala Gln Met 
            180                 185                 190         


Leu Ile Phe Thr Pro Thr Ala Thr Val Ala Thr Val Gln Pro Glu Leu 
        195                 200                 205             


Gly Thr Gly Ser Pro Ala Arg Pro Pro Thr Pro Ala Gln Val Gln Asn 
    210                 215                 220                 


Leu Thr Leu Arg Thr Gln Gln Thr Pro Ala Ala Ala Ala Ser Gly Pro 
225                 230                 235                 240 


Thr Pro Thr Gln Pro Val Leu Pro Ser Leu Ala Leu Lys Pro Thr Pro 
                245                 250                 255     


Gly Gly Ser Gln Pro Leu Pro Thr Pro Ala Gln Ser Arg Asn Thr Ala 
            260                 265                 270         


Gln Ala Ser Pro Ala Gly Ala Lys Pro Gly Ile Ala Asp Ser Val Met 
        275                 280                 285             


Glu Pro His Lys Lys Gly Asp Gly Asn Ser Ser Val Pro Gly Ser Met 
    290                 295                 300                 


Glu Gly Arg Ala Gly Leu Ser Arg Thr Val Pro Ala Val Ala Ala His 
305                 310                 315                 320 


Pro Leu Ile Ala Pro Ala Tyr Ala Gln Leu Gln Pro His Gln Leu Leu 
                325                 330                 335     


Pro Gln Pro Ser Ser Lys His Leu Gln Pro Gln Phe Val Ile Gln Gln 
            340                 345                 350         


Gln Pro Gln Pro Gln Gln Gln Gln Pro Pro Pro Gln Gln Ser Arg Pro 
        355                 360                 365             


Val Leu Gln Ala Glu Pro His Pro Gln Leu Ala Ser Val Ser Pro Ser 
    370                 375                 380                 


Val Ala Leu Gln Pro Ser Ser Glu Ala His Ala Met Pro Leu Gly Pro 
385                 390                 395                 400 


Val Thr Pro Ala Leu Pro Leu Gln Cys Pro Thr Ala Asn Leu His Lys 
                405                 410                 415     


Pro Gly Gly Ser Gln Gln Cys His Pro Pro Thr Pro Asp Thr Gly Pro 
            420                 425                 430         


Gln Asn Gly His Pro Glu Gly Val Pro His Thr Pro Gln Arg Arg Phe 
        435                 440                 445             


Gln His Thr Ser Ala Val Ile Leu Gln Leu Gln Pro Ala Ser Pro Pro 
    450                 455                 460                 


Gln Gln Cys Val Pro Asp Asp Trp Lys Glu Val Ala Pro Gly Glu Lys 
465                 470                 475                 480 


Ser Val Pro Glu Thr Arg Ser Gly Pro Ser Pro His Gln Gln Ala Ile 
                485                 490                 495     


Val Thr Ala Met Pro Gly Gly Leu Pro Val Pro Thr Ser Pro Asn Ile 
            500                 505                 510         


Gln Pro Ser Pro Ala His Glu Thr Gly Gln Gly Ile Val His Ala Leu 
        515                 520                 525             


Thr Asp Leu Ser Ser Pro Gly Met Thr Ser Gly Asn Gly Asn Ser Ala 
    530                 535                 540                 


Ser Ser Ile Ala Gly Thr Ala Pro Gln Asn Gly Glu Asn Lys Pro Pro 
545                 550                 555                 560 


Gln Ala Ile Val Lys Pro Gln Ile Leu Thr His Val Ile Glu Gly Phe 
                565                 570                 575     


Val Ile Gln Glu Gly Ala Glu Pro Phe Pro Val Gly Arg Ser Ser Leu 
            580                 585                 590         


Leu Val Gly Asn Leu Lys Lys Lys Tyr Ala Gln Gly Phe Leu Pro Glu 
        595                 600                 605             


Lys Leu Pro Gln Gln Asp His Thr Thr Thr Thr Asp Ser Glu Met Glu 
    610                 615                 620                 


Glu Pro Tyr Leu Gln Glu Ser Lys Glu Glu Gly Ala Pro Leu Lys Leu 
625                 630                 635                 640 


Lys Cys Glu Leu Cys Gly Arg Val Asp Phe Ala Tyr Lys Phe Lys Arg 
                645                 650                 655     


Ser Lys Arg Phe Cys Ser Met Ala Cys Ala Lys Arg Tyr Asn Val Gly 
            660                 665                 670         


Cys Thr Lys Arg Val Gly Leu Phe His Ser Asp Arg Ser Lys Leu Gln 
        675                 680                 685             


Lys Ala Gly Ala Ala Thr His Asn Arg Arg Arg Ala Ser Lys Ala Ser 
    690                 695                 700                 


Leu Pro Pro Leu Thr Lys Asp Thr Lys Lys Gln Pro Thr Gly Thr Val 
705                 710                 715                 720 


Pro Leu Ser Val Thr Ala Ala Leu Gln Leu Thr His Ser Gln Glu Asp 
                725                 730                 735     


Ser Ser Arg Cys Ser Asp Asn Ser Ser Tyr Glu Glu Pro Leu Ser Pro 
            740                 745                 750         


Ile Ser Ala Ser Ser Ser Thr Ser Arg Arg Arg Gln Gly Gln Arg Asp 
        755                 760                 765             


Leu Glu Leu Pro Asp Met His Met Arg Asp Leu Val Gly Met Gly His 
    770                 775                 780                 


His Phe Leu Pro Ser Glu Pro Thr Lys Trp Asn Val Glu Asp Val Tyr 
785                 790                 795                 800 


Glu Phe Ile Arg Ser Leu Pro Gly Cys Gln Glu Ile Ala Glu Glu Phe 
                805                 810                 815     


Arg Ala Gln Glu Ile Asp Gly Gln Ala Leu Leu Leu Leu Lys Glu Asp 
            820                 825                 830         


His Leu Met Ser Ala Met Asn Ile Lys Leu Gly Pro Ala Leu Lys Ile 
        835                 840                 845             


Tyr Ala Arg Ile Ser Met Leu Lys Asp Ser 
    850                 855             


<210>  21
<211>  3344
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (101)..(2971)

<400>  21
gcggcagcag cggcgcgggc gggagggcga agagcagcgg ccgcctgagg ggagcccgcg       60

cctccgccgc ctgagaggag gtcgagctgc cgccggggcg atg ctg gag gag ctg        115
                                            Met Leu Glu Glu Leu           
                                            1               5             

gag tgc ggg gcg ccc ggc gcc agg gga gcc gcc aca gcc atg gat tgc        163
Glu Cys Gly Ala Pro Gly Ala Arg Gly Ala Ala Thr Ala Met Asp Cys           
                10                  15                  20                

aaa gat aga cca gct ttt cca gtt aag aag tta ata caa gcc cgt ctg        211
Lys Asp Arg Pro Ala Phe Pro Val Lys Lys Leu Ile Gln Ala Arg Leu           
            25                  30                  35                    

ccg ttt aag cgc ctg aat ctt gtc cca aag ggg aaa gcc gat gac atg        259
Pro Phe Lys Arg Leu Asn Leu Val Pro Lys Gly Lys Ala Asp Asp Met           
        40                  45                  50                        

tca gac gat cag ggt act tct gtg caa agt aaa agc ccc gat tta gag        307
Ser Asp Asp Gln Gly Thr Ser Val Gln Ser Lys Ser Pro Asp Leu Glu           
    55                  60                  65                            

gcc tct ttg gac acc ttg gaa aac aac tgt cat gtg ggt tct gac ata        355
Ala Ser Leu Asp Thr Leu Glu Asn Asn Cys His Val Gly Ser Asp Ile           
70                  75                  80                  85            

gac ttt aga ccg aaa ctt gtc aac ggg aag ggt ccc tta gat aac ttt        403
Asp Phe Arg Pro Lys Leu Val Asn Gly Lys Gly Pro Leu Asp Asn Phe           
                90                  95                  100               

tta aga aat aga atc gaa acc agt att ggc cag agc aca gtc atc att        451
Leu Arg Asn Arg Ile Glu Thr Ser Ile Gly Gln Ser Thr Val Ile Ile           
            105                 110                 115                   

gat ttg aca gag gac tcg aat gag cag cca gac agt ctt gtg gac cac        499
Asp Leu Thr Glu Asp Ser Asn Glu Gln Pro Asp Ser Leu Val Asp His           
        120                 125                 130                       

aat aaa cta aat tct gaa gcc tct ccc tcc agg gag gca ata aat ggc        547
Asn Lys Leu Asn Ser Glu Ala Ser Pro Ser Arg Glu Ala Ile Asn Gly           
    135                 140                 145                           

cag cga gaa gac act ggg gat cag cag ggg ttg ttg aag gcc att cag        595
Gln Arg Glu Asp Thr Gly Asp Gln Gln Gly Leu Leu Lys Ala Ile Gln           
150                 155                 160                 165           

aac gac aag ttg gca ttt cct gga gag acc ctt tca gac att cct tgc        643
Asn Asp Lys Leu Ala Phe Pro Gly Glu Thr Leu Ser Asp Ile Pro Cys           
                170                 175                 180               

aaa aca gag gag gag ggt gtt ggc tgt gga ggt gca ggg agg aga ggc        691
Lys Thr Glu Glu Glu Gly Val Gly Cys Gly Gly Ala Gly Arg Arg Gly           
            185                 190                 195                   

gac tcc cag gaa tgt tcg cca cgg agc tgc ccg gag ctg acg agt ggc        739
Asp Ser Gln Glu Cys Ser Pro Arg Ser Cys Pro Glu Leu Thr Ser Gly           
        200                 205                 210                       

ccg aga atg tgc ccc aga aag gag cag gac agt tgg agt gaa gct ggg        787
Pro Arg Met Cys Pro Arg Lys Glu Gln Asp Ser Trp Ser Glu Ala Gly           
    215                 220                 225                           

ggc atc ctg ttc aaa ggg aag gtg cct atg gtg gtc ttg cag gac atc        835
Gly Ile Leu Phe Lys Gly Lys Val Pro Met Val Val Leu Gln Asp Ile           
230                 235                 240                 245           

ttg gct gtg aga cca ccg caa atc aag tcc ctt cca gcc aca ccc caa        883
Leu Ala Val Arg Pro Pro Gln Ile Lys Ser Leu Pro Ala Thr Pro Gln           
                250                 255                 260               

ggc aag aac atg acc cct gag agt gag gtg ctg gaa tct ttc ccc gaa        931
Gly Lys Asn Met Thr Pro Glu Ser Glu Val Leu Glu Ser Phe Pro Glu           
            265                 270                 275                   

gaa gac tct gta ctc agc cat tcg tcc ctg agc tct ccc tct tcc acc        979
Glu Asp Ser Val Leu Ser His Ser Ser Leu Ser Ser Pro Ser Ser Thr           
        280                 285                 290                       

agc tcg ccc gag ggg ccg cct gct ccc cca aag cag cac agc agt acc       1027
Ser Ser Pro Glu Gly Pro Pro Ala Pro Pro Lys Gln His Ser Ser Thr           
    295                 300                 305                           

agt ccc ttc ccc acc tcc acg ccc ctc cgc aga ata act aag aaa ttc       1075
Ser Pro Phe Pro Thr Ser Thr Pro Leu Arg Arg Ile Thr Lys Lys Phe           
310                 315                 320                 325           

gtc aaa ggc tct aca gag aag aac aag ctc aga ctg caa aga gat cag       1123
Val Lys Gly Ser Thr Glu Lys Asn Lys Leu Arg Leu Gln Arg Asp Gln           
                330                 335                 340               

gag cgt ctg ggc aag cag ctc aag tta cgt gca gaa agg gaa gaa aag       1171
Glu Arg Leu Gly Lys Gln Leu Lys Leu Arg Ala Glu Arg Glu Glu Lys           
            345                 350                 355                   

gag aag ctg aaa gag gag gcc aag cgg gcc aag gag gag gcc aag aag       1219
Glu Lys Leu Lys Glu Glu Ala Lys Arg Ala Lys Glu Glu Ala Lys Lys           
        360                 365                 370                       

aag aag gag gaa gag aag gag ctt aag gaa aag gag agg cgg gag aag       1267
Lys Lys Glu Glu Glu Lys Glu Leu Lys Glu Lys Glu Arg Arg Glu Lys           
    375                 380                 385                           

cgg gag aag gat gag aag gag aag gcg gag aag cag cgg ctc aag gag       1315
Arg Glu Lys Asp Glu Lys Glu Lys Ala Glu Lys Gln Arg Leu Lys Glu           
390                 395                 400                 405           

gag cgg cgc aag gag aga cag gaa gcc ctg gag gct aaa ctt gag gaa       1363
Glu Arg Arg Lys Glu Arg Gln Glu Ala Leu Glu Ala Lys Leu Glu Glu           
                410                 415                 420               

aaa agg aaa aag gaa gaa gag aaa cgg tta aga gaa gaa gag aag cgc       1411
Lys Arg Lys Lys Glu Glu Glu Lys Arg Leu Arg Glu Glu Glu Lys Arg           
            425                 430                 435                   

att aaa gca gag aag gcc gaa atc acg agg ttc ttc cag aaa cca aag       1459
Ile Lys Ala Glu Lys Ala Glu Ile Thr Arg Phe Phe Gln Lys Pro Lys           
        440                 445                 450                       

act cca cag gcc ccc aag acc ctg gcc ggc tcc tgt ggg aag ttt gcc       1507
Thr Pro Gln Ala Pro Lys Thr Leu Ala Gly Ser Cys Gly Lys Phe Ala           
    455                 460                 465                           

ccc ttt gaa att aaa gag cac atg gtc ctg gcc cct cgg cgt cgg acc       1555
Pro Phe Glu Ile Lys Glu His Met Val Leu Ala Pro Arg Arg Arg Thr           
470                 475                 480                 485           

gct ttc cat cca gac ctc tgc agt cag ctg gac cag ctc ctc cag cag       1603
Ala Phe His Pro Asp Leu Cys Ser Gln Leu Asp Gln Leu Leu Gln Gln           
                490                 495                 500               

cag agc ggc gag ttc tcc ttc ttg aaa gac ctc aaa ggc cgg cag ccc       1651
Gln Ser Gly Glu Phe Ser Phe Leu Lys Asp Leu Lys Gly Arg Gln Pro           
            505                 510                 515                   

ctg agg tcc gga ccc acg cac gtt tcc acc cgg aat gca gat att ttt       1699
Leu Arg Ser Gly Pro Thr His Val Ser Thr Arg Asn Ala Asp Ile Phe           
        520                 525                 530                       

aac agt gat gtc gtc atc gtg gag cgt ggg aag ggc gac ggt gtt ccc       1747
Asn Ser Asp Val Val Ile Val Glu Arg Gly Lys Gly Asp Gly Val Pro           
    535                 540                 545                           

gag agg agg aag ttt ggc agg atg aag ctc ctg cag ttc tgt gag aac       1795
Glu Arg Arg Lys Phe Gly Arg Met Lys Leu Leu Gln Phe Cys Glu Asn           
550                 555                 560                 565           

cac cgg cct gcc tac tgg ggt acc tgg aat aag aag acg gca ctc atc       1843
His Arg Pro Ala Tyr Trp Gly Thr Trp Asn Lys Lys Thr Ala Leu Ile           
                570                 575                 580               

cgc gcg cga gac ccc tgg gcc cag gac acg aag ctc ctg gac tat gag       1891
Arg Ala Arg Asp Pro Trp Ala Gln Asp Thr Lys Leu Leu Asp Tyr Glu           
            585                 590                 595                   

gtg gac agt gat gag gag tgg gaa gaa gag gag cct ggg gag tcc ctg       1939
Val Asp Ser Asp Glu Glu Trp Glu Glu Glu Glu Pro Gly Glu Ser Leu           
        600                 605                 610                       

tcc cac agt gag ggg gat gat gat gac gac atg gga gag gat gaa gat       1987
Ser His Ser Glu Gly Asp Asp Asp Asp Asp Met Gly Glu Asp Glu Asp           
    615                 620                 625                           

gag gac gat ggt ttc ttt gtg ccc cat ggg tac ctg tct gag gac gaa       2035
Glu Asp Asp Gly Phe Phe Val Pro His Gly Tyr Leu Ser Glu Asp Glu           
630                 635                 640                 645           

ggt gtg aca gag gag tgt gcc gac cct gag aac cat aag gtc cgc cag       2083
Gly Val Thr Glu Glu Cys Ala Asp Pro Glu Asn His Lys Val Arg Gln           
                650                 655                 660               

aaa ctg aag gcc aag gag tgg gac gag ttc ctg gct aag ggg aag cgc       2131
Lys Leu Lys Ala Lys Glu Trp Asp Glu Phe Leu Ala Lys Gly Lys Arg           
            665                 670                 675                   

ttt cgc gtc ctg caa cct gtg aag atc ggc tgc gtg tgg gcg gct gac       2179
Phe Arg Val Leu Gln Pro Val Lys Ile Gly Cys Val Trp Ala Ala Asp           
        680                 685                 690                       

aga gac tgc gca ggc gat gac ctg aag gta ctg cag cag ttc gca gcc       2227
Arg Asp Cys Ala Gly Asp Asp Leu Lys Val Leu Gln Gln Phe Ala Ala           
    695                 700                 705                           

tgc ttc ctg gag acc ctg ccg gcc cag gag gag cag acg ccc aag gcc       2275
Cys Phe Leu Glu Thr Leu Pro Ala Gln Glu Glu Gln Thr Pro Lys Ala           
710                 715                 720                 725           

tcc aag cgg gag agg aga gac gag cag atc ctg gcc cag ctg ctg ccg       2323
Ser Lys Arg Glu Arg Arg Asp Glu Gln Ile Leu Ala Gln Leu Leu Pro           
                730                 735                 740               

ctc ctg cac ggc aat gtg aac ggg agc aag gtc atc atc cgg gag ttc       2371
Leu Leu His Gly Asn Val Asn Gly Ser Lys Val Ile Ile Arg Glu Phe           
            745                 750                 755                   

cag gag cac tgc cgc cgg gga ctg ctc agc aac cac acc ggc agc ccg       2419
Gln Glu His Cys Arg Arg Gly Leu Leu Ser Asn His Thr Gly Ser Pro           
        760                 765                 770                       

cgg agc ccc tcc acc acc tac ctg cac acc ccc acc ccc agc gag gat       2467
Arg Ser Pro Ser Thr Thr Tyr Leu His Thr Pro Thr Pro Ser Glu Asp           
    775                 780                 785                           

gcc gcc atc ccc tct aag tcc cgg ctc aag cgg ctc att tcc gag aac       2515
Ala Ala Ile Pro Ser Lys Ser Arg Leu Lys Arg Leu Ile Ser Glu Asn           
790                 795                 800                 805           

tca gtg tat gag aag cgg cct gac ttc agg atg tgc tgg tac gtg cac       2563
Ser Val Tyr Glu Lys Arg Pro Asp Phe Arg Met Cys Trp Tyr Val His           
                810                 815                 820               

ccg cag gtg cta cag agc ttc cag cag gag cac ctg ccc gtg ccg tgc       2611
Pro Gln Val Leu Gln Ser Phe Gln Gln Glu His Leu Pro Val Pro Cys           
            825                 830                 835                   

cag tgg agc tat gtg aca tcg gtg ccc tcg gcc ccc aaa gag gac agt       2659
Gln Trp Ser Tyr Val Thr Ser Val Pro Ser Ala Pro Lys Glu Asp Ser           
        840                 845                 850                       

ggc agc gtc ccc tcc acg ggg ccc agc cag ggc act ccc atc tcg ctg       2707
Gly Ser Val Pro Ser Thr Gly Pro Ser Gln Gly Thr Pro Ile Ser Leu           
    855                 860                 865                           

aag agg aag tca gcg ggc agc atg tgc atc acc caa ttc atg aag aag       2755
Lys Arg Lys Ser Ala Gly Ser Met Cys Ile Thr Gln Phe Met Lys Lys           
870                 875                 880                 885           

cgc agg cac gac ggc cag att ggt gct gaa gac atg gac ggc ttc cag       2803
Arg Arg His Asp Gly Gln Ile Gly Ala Glu Asp Met Asp Gly Phe Gln           
                890                 895                 900               

gca gac acg gag gag gag gaa gag gag gag ggc gac tgt atg atc gtg       2851
Ala Asp Thr Glu Glu Glu Glu Glu Glu Glu Gly Asp Cys Met Ile Val           
            905                 910                 915                   

gat gtc ccg gat gct gcg gag gtc caa gcc ccg tgt gga gcc gct tcc       2899
Asp Val Pro Asp Ala Ala Glu Val Gln Ala Pro Cys Gly Ala Ala Ser           
        920                 925                 930                       

gga gct ggg ggt ggt gtg ggg gtg gac acc ggc aag gcc acc ctg acc       2947
Gly Ala Gly Gly Gly Val Gly Val Asp Thr Gly Lys Ala Thr Leu Thr           
    935                 940                 945                           

gcg agc cca ctg ggt gca tcc tga gagcaggggt gacgtatgta gaatgcttag      3001
Ala Ser Pro Leu Gly Ala Ser                                               
950                 955                                                   

ggtgtcctcc ccacagagca gatacttgaa ccgactcaat tcctgtgtaa agagcacttt     3061

gtcctgcttc acggacctcc ccaaagtgtg cagagttcta tataggatgc tggattagtt     3121

cctttgatat ttgtaaaaat tcccccaaga gccgcatatg aatctgccct ttaataaagc     3181

attattgaga ttgctggcct attggggaag cctgcgggca caggagcagg cgtggaatcc     3241

aatacttgta aatgaattga agcgtcagga ccacccgcct ggccacgtgc gcgggcccct     3301

ggacctaacg aggcagtgta taaacttatt ctctagccct gaa                       3344


<210>  22
<211>  956
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Leu Glu Glu Leu Glu Cys Gly Ala Pro Gly Ala Arg Gly Ala Ala 
1               5                   10                  15      


Thr Ala Met Asp Cys Lys Asp Arg Pro Ala Phe Pro Val Lys Lys Leu 
            20                  25                  30          


Ile Gln Ala Arg Leu Pro Phe Lys Arg Leu Asn Leu Val Pro Lys Gly 
        35                  40                  45              


Lys Ala Asp Asp Met Ser Asp Asp Gln Gly Thr Ser Val Gln Ser Lys 
    50                  55                  60                  


Ser Pro Asp Leu Glu Ala Ser Leu Asp Thr Leu Glu Asn Asn Cys His 
65                  70                  75                  80  


Val Gly Ser Asp Ile Asp Phe Arg Pro Lys Leu Val Asn Gly Lys Gly 
                85                  90                  95      


Pro Leu Asp Asn Phe Leu Arg Asn Arg Ile Glu Thr Ser Ile Gly Gln 
            100                 105                 110         


Ser Thr Val Ile Ile Asp Leu Thr Glu Asp Ser Asn Glu Gln Pro Asp 
        115                 120                 125             


Ser Leu Val Asp His Asn Lys Leu Asn Ser Glu Ala Ser Pro Ser Arg 
    130                 135                 140                 


Glu Ala Ile Asn Gly Gln Arg Glu Asp Thr Gly Asp Gln Gln Gly Leu 
145                 150                 155                 160 


Leu Lys Ala Ile Gln Asn Asp Lys Leu Ala Phe Pro Gly Glu Thr Leu 
                165                 170                 175     


Ser Asp Ile Pro Cys Lys Thr Glu Glu Glu Gly Val Gly Cys Gly Gly 
            180                 185                 190         


Ala Gly Arg Arg Gly Asp Ser Gln Glu Cys Ser Pro Arg Ser Cys Pro 
        195                 200                 205             


Glu Leu Thr Ser Gly Pro Arg Met Cys Pro Arg Lys Glu Gln Asp Ser 
    210                 215                 220                 


Trp Ser Glu Ala Gly Gly Ile Leu Phe Lys Gly Lys Val Pro Met Val 
225                 230                 235                 240 


Val Leu Gln Asp Ile Leu Ala Val Arg Pro Pro Gln Ile Lys Ser Leu 
                245                 250                 255     


Pro Ala Thr Pro Gln Gly Lys Asn Met Thr Pro Glu Ser Glu Val Leu 
            260                 265                 270         


Glu Ser Phe Pro Glu Glu Asp Ser Val Leu Ser His Ser Ser Leu Ser 
        275                 280                 285             


Ser Pro Ser Ser Thr Ser Ser Pro Glu Gly Pro Pro Ala Pro Pro Lys 
    290                 295                 300                 


Gln His Ser Ser Thr Ser Pro Phe Pro Thr Ser Thr Pro Leu Arg Arg 
305                 310                 315                 320 


Ile Thr Lys Lys Phe Val Lys Gly Ser Thr Glu Lys Asn Lys Leu Arg 
                325                 330                 335     


Leu Gln Arg Asp Gln Glu Arg Leu Gly Lys Gln Leu Lys Leu Arg Ala 
            340                 345                 350         


Glu Arg Glu Glu Lys Glu Lys Leu Lys Glu Glu Ala Lys Arg Ala Lys 
        355                 360                 365             


Glu Glu Ala Lys Lys Lys Lys Glu Glu Glu Lys Glu Leu Lys Glu Lys 
    370                 375                 380                 


Glu Arg Arg Glu Lys Arg Glu Lys Asp Glu Lys Glu Lys Ala Glu Lys 
385                 390                 395                 400 


Gln Arg Leu Lys Glu Glu Arg Arg Lys Glu Arg Gln Glu Ala Leu Glu 
                405                 410                 415     


Ala Lys Leu Glu Glu Lys Arg Lys Lys Glu Glu Glu Lys Arg Leu Arg 
            420                 425                 430         


Glu Glu Glu Lys Arg Ile Lys Ala Glu Lys Ala Glu Ile Thr Arg Phe 
        435                 440                 445             


Phe Gln Lys Pro Lys Thr Pro Gln Ala Pro Lys Thr Leu Ala Gly Ser 
    450                 455                 460                 


Cys Gly Lys Phe Ala Pro Phe Glu Ile Lys Glu His Met Val Leu Ala 
465                 470                 475                 480 


Pro Arg Arg Arg Thr Ala Phe His Pro Asp Leu Cys Ser Gln Leu Asp 
                485                 490                 495     


Gln Leu Leu Gln Gln Gln Ser Gly Glu Phe Ser Phe Leu Lys Asp Leu 
            500                 505                 510         


Lys Gly Arg Gln Pro Leu Arg Ser Gly Pro Thr His Val Ser Thr Arg 
        515                 520                 525             


Asn Ala Asp Ile Phe Asn Ser Asp Val Val Ile Val Glu Arg Gly Lys 
    530                 535                 540                 


Gly Asp Gly Val Pro Glu Arg Arg Lys Phe Gly Arg Met Lys Leu Leu 
545                 550                 555                 560 


Gln Phe Cys Glu Asn His Arg Pro Ala Tyr Trp Gly Thr Trp Asn Lys 
                565                 570                 575     


Lys Thr Ala Leu Ile Arg Ala Arg Asp Pro Trp Ala Gln Asp Thr Lys 
            580                 585                 590         


Leu Leu Asp Tyr Glu Val Asp Ser Asp Glu Glu Trp Glu Glu Glu Glu 
        595                 600                 605             


Pro Gly Glu Ser Leu Ser His Ser Glu Gly Asp Asp Asp Asp Asp Met 
    610                 615                 620                 


Gly Glu Asp Glu Asp Glu Asp Asp Gly Phe Phe Val Pro His Gly Tyr 
625                 630                 635                 640 


Leu Ser Glu Asp Glu Gly Val Thr Glu Glu Cys Ala Asp Pro Glu Asn 
                645                 650                 655     


His Lys Val Arg Gln Lys Leu Lys Ala Lys Glu Trp Asp Glu Phe Leu 
            660                 665                 670         


Ala Lys Gly Lys Arg Phe Arg Val Leu Gln Pro Val Lys Ile Gly Cys 
        675                 680                 685             


Val Trp Ala Ala Asp Arg Asp Cys Ala Gly Asp Asp Leu Lys Val Leu 
    690                 695                 700                 


Gln Gln Phe Ala Ala Cys Phe Leu Glu Thr Leu Pro Ala Gln Glu Glu 
705                 710                 715                 720 


Gln Thr Pro Lys Ala Ser Lys Arg Glu Arg Arg Asp Glu Gln Ile Leu 
                725                 730                 735     


Ala Gln Leu Leu Pro Leu Leu His Gly Asn Val Asn Gly Ser Lys Val 
            740                 745                 750         


Ile Ile Arg Glu Phe Gln Glu His Cys Arg Arg Gly Leu Leu Ser Asn 
        755                 760                 765             


His Thr Gly Ser Pro Arg Ser Pro Ser Thr Thr Tyr Leu His Thr Pro 
    770                 775                 780                 


Thr Pro Ser Glu Asp Ala Ala Ile Pro Ser Lys Ser Arg Leu Lys Arg 
785                 790                 795                 800 


Leu Ile Ser Glu Asn Ser Val Tyr Glu Lys Arg Pro Asp Phe Arg Met 
                805                 810                 815     


Cys Trp Tyr Val His Pro Gln Val Leu Gln Ser Phe Gln Gln Glu His 
            820                 825                 830         


Leu Pro Val Pro Cys Gln Trp Ser Tyr Val Thr Ser Val Pro Ser Ala 
        835                 840                 845             


Pro Lys Glu Asp Ser Gly Ser Val Pro Ser Thr Gly Pro Ser Gln Gly 
    850                 855                 860                 


Thr Pro Ile Ser Leu Lys Arg Lys Ser Ala Gly Ser Met Cys Ile Thr 
865                 870                 875                 880 


Gln Phe Met Lys Lys Arg Arg His Asp Gly Gln Ile Gly Ala Glu Asp 
                885                 890                 895     


Met Asp Gly Phe Gln Ala Asp Thr Glu Glu Glu Glu Glu Glu Glu Gly 
            900                 905                 910         


Asp Cys Met Ile Val Asp Val Pro Asp Ala Ala Glu Val Gln Ala Pro 
        915                 920                 925             


Cys Gly Ala Ala Ser Gly Ala Gly Gly Gly Val Gly Val Asp Thr Gly 
    930                 935                 940                 


Lys Ala Thr Leu Thr Ala Ser Pro Leu Gly Ala Ser 
945                 950                 955     


<210>  23
<211>  4007
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (216)..(3368)

<400>  23
gacagatacc ctccttccgg ccgcgccact cgggaggcgg atcccgtggg cctgaggagg       60

cttcccccgc ccggtttgct ttccctccct cgctggcgct gccgcgagtc caccgagcgg      120

cctctgagga gcagccgcag gaggaggagg aggtcgtcgg gggcggcggg cggagaccgc      180

gctctcgctt ccccggcggc ggcaagggca ggaca atg gag gtg gcg gtg gag         233
                                       Met Glu Val Ala Val Glu            
                                       1               5                  

aag gcg gtg gcg gcg gcg gca gcg gcc tcg gct gcg gcc tcc ggg ggg        281
Lys Ala Val Ala Ala Ala Ala Ala Ala Ser Ala Ala Ala Ser Gly Gly           
            10                  15                  20                    

ccc tcg gcg gcg ccg agc ggg gag aac gag gcc gag agt cgg cag ggc        329
Pro Ser Ala Ala Pro Ser Gly Glu Asn Glu Ala Glu Ser Arg Gln Gly           
        25                  30                  35                        

ccg gac tcg gag cgc ggc ggc gag gcg gcc cgg ctc aac ctg ttg gac        377
Pro Asp Ser Glu Arg Gly Gly Glu Ala Ala Arg Leu Asn Leu Leu Asp           
    40                  45                  50                            

act tgc gcc gtg tgc cac cag aac atc cag agc cgg gcg ccc aag ctg        425
Thr Cys Ala Val Cys His Gln Asn Ile Gln Ser Arg Ala Pro Lys Leu           
55                  60                  65                  70            

ctg ccc tgc ctg cac tct ttc tgc cag cgc tgc ctg ccc gcg ccc cag        473
Leu Pro Cys Leu His Ser Phe Cys Gln Arg Cys Leu Pro Ala Pro Gln           
                75                  80                  85                

cgc tac ctc atg ctg ccc gcg ccc atg ctg ggc tcg gcc gag acc ccg        521
Arg Tyr Leu Met Leu Pro Ala Pro Met Leu Gly Ser Ala Glu Thr Pro           
            90                  95                  100                   

cca ccc gtc cct gcc ccc ggc tcg ccg gtc agc ggc tcg tcg ccg ttc        569
Pro Pro Val Pro Ala Pro Gly Ser Pro Val Ser Gly Ser Ser Pro Phe           
        105                 110                 115                       

gcc acc caa gtt gga gtc att cgt tgc cca gtt tgc agc caa gaa tgt        617
Ala Thr Gln Val Gly Val Ile Arg Cys Pro Val Cys Ser Gln Glu Cys           
    120                 125                 130                           

gca gag aga cac atc ata gat aac ttt ttt gtg aag gac act act gag        665
Ala Glu Arg His Ile Ile Asp Asn Phe Phe Val Lys Asp Thr Thr Glu           
135                 140                 145                 150           

gtt ccc agc agt aca gta gaa aag tca aat cag gta tgt aca agc tgt        713
Val Pro Ser Ser Thr Val Glu Lys Ser Asn Gln Val Cys Thr Ser Cys           
                155                 160                 165               

gag gac aac gca gaa gcc aat ggg ttt tgt gta gag tgt gtt gaa tgg        761
Glu Asp Asn Ala Glu Ala Asn Gly Phe Cys Val Glu Cys Val Glu Trp           
            170                 175                 180                   

ctc tgc aag acg tgt atc aga gct cat cag agg gta aag ttc aca aaa        809
Leu Cys Lys Thr Cys Ile Arg Ala His Gln Arg Val Lys Phe Thr Lys           
        185                 190                 195                       

gac cac act gtc aga cag aaa gag gaa gta tct cca gag gca gtt ggt        857
Asp His Thr Val Arg Gln Lys Glu Glu Val Ser Pro Glu Ala Val Gly           
    200                 205                 210                           

gtc acc agc cag cga cca gtg ttt tgt cct ttt cat aaa aag gag cag        905
Val Thr Ser Gln Arg Pro Val Phe Cys Pro Phe His Lys Lys Glu Gln           
215                 220                 225                 230           

ctg aag ctg tac tgt gag aca tgt gac aaa ctg aca tgt cga gac tgt        953
Leu Lys Leu Tyr Cys Glu Thr Cys Asp Lys Leu Thr Cys Arg Asp Cys           
                235                 240                 245               

cag ttg tta gaa cat aaa gag cat aga tac caa ttt ata gaa gaa gct       1001
Gln Leu Leu Glu His Lys Glu His Arg Tyr Gln Phe Ile Glu Glu Ala           
            250                 255                 260                   

ttt cag aat cag aaa gtg atc ata gat aca cta atc acc aaa ctg atg       1049
Phe Gln Asn Gln Lys Val Ile Ile Asp Thr Leu Ile Thr Lys Leu Met           
        265                 270                 275                       

gaa aaa aca aaa tac ata aaa ttc aca gga aat cag atc caa aac aga       1097
Glu Lys Thr Lys Tyr Ile Lys Phe Thr Gly Asn Gln Ile Gln Asn Arg           
    280                 285                 290                           

att att gaa gta aat caa aat caa aag cag gtg gaa cag gat att aaa       1145
Ile Ile Glu Val Asn Gln Asn Gln Lys Gln Val Glu Gln Asp Ile Lys           
295                 300                 305                 310           

gtt gct ata ttt aca ctg atg gta gaa ata aat aaa aaa gga aaa gct       1193
Val Ala Ile Phe Thr Leu Met Val Glu Ile Asn Lys Lys Gly Lys Ala           
                315                 320                 325               

cta ctg cat cag tta gag agc ctt gca aag gac cat cgc atg aaa ctt       1241
Leu Leu His Gln Leu Glu Ser Leu Ala Lys Asp His Arg Met Lys Leu           
            330                 335                 340                   

atg caa caa caa cag gaa gtg gct gga ctc tct aaa caa ttg gag cat       1289
Met Gln Gln Gln Gln Glu Val Ala Gly Leu Ser Lys Gln Leu Glu His           
        345                 350                 355                       

gtc atg cat ttt tct aaa tgg gca gtt tcc agt ggc agc agt aca gca       1337
Val Met His Phe Ser Lys Trp Ala Val Ser Ser Gly Ser Ser Thr Ala           
    360                 365                 370                           

tta ctt tat agc aaa cga ctg att aca tac cgg tta cgg cac ctc ctt       1385
Leu Leu Tyr Ser Lys Arg Leu Ile Thr Tyr Arg Leu Arg His Leu Leu           
375                 380                 385                 390           

cgt gca agg tgt gat gca tcc cca gtg acc aac aac acc atc caa ttt       1433
Arg Ala Arg Cys Asp Ala Ser Pro Val Thr Asn Asn Thr Ile Gln Phe           
                395                 400                 405               

cac tgt gat cct agt ttc tgg gct caa aat atc atc aac tta ggt tct       1481
His Cys Asp Pro Ser Phe Trp Ala Gln Asn Ile Ile Asn Leu Gly Ser           
            410                 415                 420                   

tta gta atc gag gat aaa gag agc cag cca caa atg cct aag cag aat       1529
Leu Val Ile Glu Asp Lys Glu Ser Gln Pro Gln Met Pro Lys Gln Asn           
        425                 430                 435                       

cct gtc gtg gaa cag aat tca cag cca cca agt ggt tta tca tca aac       1577
Pro Val Val Glu Gln Asn Ser Gln Pro Pro Ser Gly Leu Ser Ser Asn           
    440                 445                 450                           

cag tta tcc aag ttc cca aca cag atc agc cta gct caa tta cgg ctc       1625
Gln Leu Ser Lys Phe Pro Thr Gln Ile Ser Leu Ala Gln Leu Arg Leu           
455                 460                 465                 470           

cag cat atg cag caa cag gta atg gct cag agg caa cag gtg caa cgg       1673
Gln His Met Gln Gln Gln Val Met Ala Gln Arg Gln Gln Val Gln Arg           
                475                 480                 485               

agg cca gca cct gtg ggt tta cca aac cct aga atg cag ggg ccc atc       1721
Arg Pro Ala Pro Val Gly Leu Pro Asn Pro Arg Met Gln Gly Pro Ile           
            490                 495                 500                   

cag caa cct tcc atc tct cat cag caa ccg cct cca cgt ttg ata aac       1769
Gln Gln Pro Ser Ile Ser His Gln Gln Pro Pro Pro Arg Leu Ile Asn           
        505                 510                 515                       

ttt cag aat cac agc ccc aaa ccc aat gga cca gtt ctt cct cct cat       1817
Phe Gln Asn His Ser Pro Lys Pro Asn Gly Pro Val Leu Pro Pro His           
    520                 525                 530                           

cct caa caa ctg aga tat cca cca aac cag aac ata cca cga caa gca       1865
Pro Gln Gln Leu Arg Tyr Pro Pro Asn Gln Asn Ile Pro Arg Gln Ala           
535                 540                 545                 550           

ata aag cca aac ccc cta cag atg gct ttc ttg gct caa caa gcc ata       1913
Ile Lys Pro Asn Pro Leu Gln Met Ala Phe Leu Ala Gln Gln Ala Ile           
                555                 560                 565               

aaa cag tgg cag atc agc agt gga cag gga acc cca tca act acc aac       1961
Lys Gln Trp Gln Ile Ser Ser Gly Gln Gly Thr Pro Ser Thr Thr Asn           
            570                 575                 580                   

agc aca tcc tct act cct tcc agc ccc acg att act agt gca gca gga       2009
Ser Thr Ser Ser Thr Pro Ser Ser Pro Thr Ile Thr Ser Ala Ala Gly           
        585                 590                 595                       

tat gat gga aag gct ttt ggt tca cct atg atc gat ttg agc tca cca       2057
Tyr Asp Gly Lys Ala Phe Gly Ser Pro Met Ile Asp Leu Ser Ser Pro           
    600                 605                 610                           

gtg gga ggg tct tat aat ctt ccc tct ctt ccg gat att gac tgt tca       2105
Val Gly Gly Ser Tyr Asn Leu Pro Ser Leu Pro Asp Ile Asp Cys Ser           
615                 620                 625                 630           

agt act att atg ctg gac aat att gtg agg aaa gat act aat ata gat       2153
Ser Thr Ile Met Leu Asp Asn Ile Val Arg Lys Asp Thr Asn Ile Asp           
                635                 640                 645               

cat ggc cag cca aga cca ccc tca aac aga acg gtc cag tca cca aat       2201
His Gly Gln Pro Arg Pro Pro Ser Asn Arg Thr Val Gln Ser Pro Asn           
            650                 655                 660                   

tca tca gtg cca tct cca ggc ctt gca gga cct gtt act atg act agt       2249
Ser Ser Val Pro Ser Pro Gly Leu Ala Gly Pro Val Thr Met Thr Ser           
        665                 670                 675                       

gta cac ccc cca ata cgt tca cct agt gcc tcc agc gtt gga agc cga       2297
Val His Pro Pro Ile Arg Ser Pro Ser Ala Ser Ser Val Gly Ser Arg           
    680                 685                 690                           

gga agc tct ggc tct tcc agc aaa cca gca gga gct gac tct aca cac       2345
Gly Ser Ser Gly Ser Ser Ser Lys Pro Ala Gly Ala Asp Ser Thr His           
695                 700                 705                 710           

aaa gtc cca gtg gtc atg ctg gag cca att cga ata aaa caa gaa aac       2393
Lys Val Pro Val Val Met Leu Glu Pro Ile Arg Ile Lys Gln Glu Asn           
                715                 720                 725               

agt gga cca ccg gaa aat tat gat ttc cct gtt gtt ata gtg aag caa       2441
Ser Gly Pro Pro Glu Asn Tyr Asp Phe Pro Val Val Ile Val Lys Gln           
            730                 735                 740                   

gaa tca gat gaa gaa tct agg cct caa aat gcc aat tat cca aga agc       2489
Glu Ser Asp Glu Glu Ser Arg Pro Gln Asn Ala Asn Tyr Pro Arg Ser           
        745                 750                 755                       

ata ctc acc tcc ctg ctc tta aat agc agt cag agc tct act tct gag       2537
Ile Leu Thr Ser Leu Leu Leu Asn Ser Ser Gln Ser Ser Thr Ser Glu           
    760                 765                 770                           

gag act gtg cta aga tca gat gcc cct gat agt aca gga gat caa cct       2585
Glu Thr Val Leu Arg Ser Asp Ala Pro Asp Ser Thr Gly Asp Gln Pro           
775                 780                 785                 790           

gga ctt cac cag gac aat tcc tca aat gga aag tct gaa tgg ttg gat       2633
Gly Leu His Gln Asp Asn Ser Ser Asn Gly Lys Ser Glu Trp Leu Asp           
                795                 800                 805               

cct tcc cag aag tca cct ctt cat gtt gga gag aca agg aaa gag gat       2681
Pro Ser Gln Lys Ser Pro Leu His Val Gly Glu Thr Arg Lys Glu Asp           
            810                 815                 820                   

gac ccc aat gag gac tgg tgt gca gtt tgt caa aac gga ggg gaa ctc       2729
Asp Pro Asn Glu Asp Trp Cys Ala Val Cys Gln Asn Gly Gly Glu Leu           
        825                 830                 835                       

ctc tgc tgt gaa aag tgc ccc aaa gta ttc cat ctt tct tgt cat gtg       2777
Leu Cys Cys Glu Lys Cys Pro Lys Val Phe His Leu Ser Cys His Val           
    840                 845                 850                           

ccc aca ttg aca aat ttt cca agt gga gag tgg att tgc act ttc tgc       2825
Pro Thr Leu Thr Asn Phe Pro Ser Gly Glu Trp Ile Cys Thr Phe Cys           
855                 860                 865                 870           

cga gac tta tct aaa cca gaa gtt gaa tat gat tgt gat gct ccc agt       2873
Arg Asp Leu Ser Lys Pro Glu Val Glu Tyr Asp Cys Asp Ala Pro Ser           
                875                 880                 885               

cac aac tca gaa aaa aag aaa act gaa ggc ctt gtt aag tta aca cct       2921
His Asn Ser Glu Lys Lys Lys Thr Glu Gly Leu Val Lys Leu Thr Pro           
            890                 895                 900                   

ata gat aaa agg aag tgt gag cgc cta ctt tta ttt ctt tac tgc cat       2969
Ile Asp Lys Arg Lys Cys Glu Arg Leu Leu Leu Phe Leu Tyr Cys His           
        905                 910                 915                       

gaa atg agc ctg gct ttt caa gac cct gtt cct cta act gtg cct gat       3017
Glu Met Ser Leu Ala Phe Gln Asp Pro Val Pro Leu Thr Val Pro Asp           
    920                 925                 930                           

tat tac aaa ata att aaa aat cca atg gat ttg tca acc atc aag aaa       3065
Tyr Tyr Lys Ile Ile Lys Asn Pro Met Asp Leu Ser Thr Ile Lys Lys           
935                 940                 945                 950           

aga cta caa gaa gat tat tcc atg tac tca aaa cct gaa gat ttt gta       3113
Arg Leu Gln Glu Asp Tyr Ser Met Tyr Ser Lys Pro Glu Asp Phe Val           
                955                 960                 965               

gct gat ttt aga ttg atc ttt caa aac tgt gct gaa ttc aat gag cct       3161
Ala Asp Phe Arg Leu Ile Phe Gln Asn Cys Ala Glu Phe Asn Glu Pro           
            970                 975                 980                   

gat tca gaa gta gcc aat gct ggt ata aaa ctt gaa aat tat ttt gaa       3209
Asp Ser Glu Val Ala Asn Ala Gly Ile Lys Leu Glu Asn Tyr Phe Glu           
        985                 990                 995                       

gaa ctt  cta aag aac ctc tat  cca gaa aaa agg ttt  ccc aaa cca        3254
Glu Leu  Leu Lys Asn Leu Tyr  Pro Glu Lys Arg Phe  Pro Lys Pro            
    1000                 1005                 1010                        

gaa ttc  agg aat gaa tca gaa  gat aat aaa ttt agt  gat gat tca        3299
Glu Phe  Arg Asn Glu Ser Glu  Asp Asn Lys Phe Ser  Asp Asp Ser            
    1015                 1020                 1025                        

gat gat  gac ttt gta cag ccc  cgg aag aaa cgc ctc  aaa agc att        3344
Asp Asp  Asp Phe Val Gln Pro  Arg Lys Lys Arg Leu  Lys Ser Ile            
    1030                 1035                 1040                        

gaa gaa  cgc cag ttg ctt aaa  taa tatgcagcac cactagcttg               3388
Glu Glu  Arg Gln Leu Leu Lys                                              
    1045                 1050                                             

tgctggtttt tagatttttt tgttttcaaa aaaacatttg tcagtaattt aacatcacta     3448

caaaaagaag agtttgtgac tattctcatc tctgttttgg acgtttacta gactttgatt     3508

tccttaatag cccatttctg ttaacctctt atcactaaga aagaaaggaa agaaggagat     3568

gaatagaaga aagaaaatgg aaagaaggaa aaaaggagga tagaaaaagg atggaagaaa     3628

gaagcattga aaacaaagac attcttccca cttcttggat ttttaaacca cagtctggag     3688

tgatagctac tgtagaaagg aaatagactt tgtatgaact ctttaagttg aaaagtaaaa     3748

aatatatgtg gtttggatgt gtgctttaat tcagctttag aaattaatac cactacccgt     3808

gaattatatg gcctgacaat atgaattagg tgtactgtac tgaagaacag tactccacaa     3868

acatgggtgg taacaagagt tccatcccag gaggccaaac ggtgcaacag aagggtaggt     3928

tagatgctat taagaaggca cttaatagta catcatgtaa gatggcaact gtattaaaga     3988

aaaatccgga aaacaaaaa                                                  4007


<210>  24
<211>  1050
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Glu Val Ala Val Glu Lys Ala Val Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ala Ala Ala Ser Gly Gly Pro Ser Ala Ala Pro Ser Gly Glu Asn Glu 
            20                  25                  30          


Ala Glu Ser Arg Gln Gly Pro Asp Ser Glu Arg Gly Gly Glu Ala Ala 
        35                  40                  45              


Arg Leu Asn Leu Leu Asp Thr Cys Ala Val Cys His Gln Asn Ile Gln 
    50                  55                  60                  


Ser Arg Ala Pro Lys Leu Leu Pro Cys Leu His Ser Phe Cys Gln Arg 
65                  70                  75                  80  


Cys Leu Pro Ala Pro Gln Arg Tyr Leu Met Leu Pro Ala Pro Met Leu 
                85                  90                  95      


Gly Ser Ala Glu Thr Pro Pro Pro Val Pro Ala Pro Gly Ser Pro Val 
            100                 105                 110         


Ser Gly Ser Ser Pro Phe Ala Thr Gln Val Gly Val Ile Arg Cys Pro 
        115                 120                 125             


Val Cys Ser Gln Glu Cys Ala Glu Arg His Ile Ile Asp Asn Phe Phe 
    130                 135                 140                 


Val Lys Asp Thr Thr Glu Val Pro Ser Ser Thr Val Glu Lys Ser Asn 
145                 150                 155                 160 


Gln Val Cys Thr Ser Cys Glu Asp Asn Ala Glu Ala Asn Gly Phe Cys 
                165                 170                 175     


Val Glu Cys Val Glu Trp Leu Cys Lys Thr Cys Ile Arg Ala His Gln 
            180                 185                 190         


Arg Val Lys Phe Thr Lys Asp His Thr Val Arg Gln Lys Glu Glu Val 
        195                 200                 205             


Ser Pro Glu Ala Val Gly Val Thr Ser Gln Arg Pro Val Phe Cys Pro 
    210                 215                 220                 


Phe His Lys Lys Glu Gln Leu Lys Leu Tyr Cys Glu Thr Cys Asp Lys 
225                 230                 235                 240 


Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His Lys Glu His Arg Tyr 
                245                 250                 255     


Gln Phe Ile Glu Glu Ala Phe Gln Asn Gln Lys Val Ile Ile Asp Thr 
            260                 265                 270         


Leu Ile Thr Lys Leu Met Glu Lys Thr Lys Tyr Ile Lys Phe Thr Gly 
        275                 280                 285             


Asn Gln Ile Gln Asn Arg Ile Ile Glu Val Asn Gln Asn Gln Lys Gln 
    290                 295                 300                 


Val Glu Gln Asp Ile Lys Val Ala Ile Phe Thr Leu Met Val Glu Ile 
305                 310                 315                 320 


Asn Lys Lys Gly Lys Ala Leu Leu His Gln Leu Glu Ser Leu Ala Lys 
                325                 330                 335     


Asp His Arg Met Lys Leu Met Gln Gln Gln Gln Glu Val Ala Gly Leu 
            340                 345                 350         


Ser Lys Gln Leu Glu His Val Met His Phe Ser Lys Trp Ala Val Ser 
        355                 360                 365             


Ser Gly Ser Ser Thr Ala Leu Leu Tyr Ser Lys Arg Leu Ile Thr Tyr 
    370                 375                 380                 


Arg Leu Arg His Leu Leu Arg Ala Arg Cys Asp Ala Ser Pro Val Thr 
385                 390                 395                 400 


Asn Asn Thr Ile Gln Phe His Cys Asp Pro Ser Phe Trp Ala Gln Asn 
                405                 410                 415     


Ile Ile Asn Leu Gly Ser Leu Val Ile Glu Asp Lys Glu Ser Gln Pro 
            420                 425                 430         


Gln Met Pro Lys Gln Asn Pro Val Val Glu Gln Asn Ser Gln Pro Pro 
        435                 440                 445             


Ser Gly Leu Ser Ser Asn Gln Leu Ser Lys Phe Pro Thr Gln Ile Ser 
    450                 455                 460                 


Leu Ala Gln Leu Arg Leu Gln His Met Gln Gln Gln Val Met Ala Gln 
465                 470                 475                 480 


Arg Gln Gln Val Gln Arg Arg Pro Ala Pro Val Gly Leu Pro Asn Pro 
                485                 490                 495     


Arg Met Gln Gly Pro Ile Gln Gln Pro Ser Ile Ser His Gln Gln Pro 
            500                 505                 510         


Pro Pro Arg Leu Ile Asn Phe Gln Asn His Ser Pro Lys Pro Asn Gly 
        515                 520                 525             


Pro Val Leu Pro Pro His Pro Gln Gln Leu Arg Tyr Pro Pro Asn Gln 
    530                 535                 540                 


Asn Ile Pro Arg Gln Ala Ile Lys Pro Asn Pro Leu Gln Met Ala Phe 
545                 550                 555                 560 


Leu Ala Gln Gln Ala Ile Lys Gln Trp Gln Ile Ser Ser Gly Gln Gly 
                565                 570                 575     


Thr Pro Ser Thr Thr Asn Ser Thr Ser Ser Thr Pro Ser Ser Pro Thr 
            580                 585                 590         


Ile Thr Ser Ala Ala Gly Tyr Asp Gly Lys Ala Phe Gly Ser Pro Met 
        595                 600                 605             


Ile Asp Leu Ser Ser Pro Val Gly Gly Ser Tyr Asn Leu Pro Ser Leu 
    610                 615                 620                 


Pro Asp Ile Asp Cys Ser Ser Thr Ile Met Leu Asp Asn Ile Val Arg 
625                 630                 635                 640 


Lys Asp Thr Asn Ile Asp His Gly Gln Pro Arg Pro Pro Ser Asn Arg 
                645                 650                 655     


Thr Val Gln Ser Pro Asn Ser Ser Val Pro Ser Pro Gly Leu Ala Gly 
            660                 665                 670         


Pro Val Thr Met Thr Ser Val His Pro Pro Ile Arg Ser Pro Ser Ala 
        675                 680                 685             


Ser Ser Val Gly Ser Arg Gly Ser Ser Gly Ser Ser Ser Lys Pro Ala 
    690                 695                 700                 


Gly Ala Asp Ser Thr His Lys Val Pro Val Val Met Leu Glu Pro Ile 
705                 710                 715                 720 


Arg Ile Lys Gln Glu Asn Ser Gly Pro Pro Glu Asn Tyr Asp Phe Pro 
                725                 730                 735     


Val Val Ile Val Lys Gln Glu Ser Asp Glu Glu Ser Arg Pro Gln Asn 
            740                 745                 750         


Ala Asn Tyr Pro Arg Ser Ile Leu Thr Ser Leu Leu Leu Asn Ser Ser 
        755                 760                 765             


Gln Ser Ser Thr Ser Glu Glu Thr Val Leu Arg Ser Asp Ala Pro Asp 
    770                 775                 780                 


Ser Thr Gly Asp Gln Pro Gly Leu His Gln Asp Asn Ser Ser Asn Gly 
785                 790                 795                 800 


Lys Ser Glu Trp Leu Asp Pro Ser Gln Lys Ser Pro Leu His Val Gly 
                805                 810                 815     


Glu Thr Arg Lys Glu Asp Asp Pro Asn Glu Asp Trp Cys Ala Val Cys 
            820                 825                 830         


Gln Asn Gly Gly Glu Leu Leu Cys Cys Glu Lys Cys Pro Lys Val Phe 
        835                 840                 845             


His Leu Ser Cys His Val Pro Thr Leu Thr Asn Phe Pro Ser Gly Glu 
    850                 855                 860                 


Trp Ile Cys Thr Phe Cys Arg Asp Leu Ser Lys Pro Glu Val Glu Tyr 
865                 870                 875                 880 


Asp Cys Asp Ala Pro Ser His Asn Ser Glu Lys Lys Lys Thr Glu Gly 
                885                 890                 895     


Leu Val Lys Leu Thr Pro Ile Asp Lys Arg Lys Cys Glu Arg Leu Leu 
            900                 905                 910         


Leu Phe Leu Tyr Cys His Glu Met Ser Leu Ala Phe Gln Asp Pro Val 
        915                 920                 925             


Pro Leu Thr Val Pro Asp Tyr Tyr Lys Ile Ile Lys Asn Pro Met Asp 
    930                 935                 940                 


Leu Ser Thr Ile Lys Lys Arg Leu Gln Glu Asp Tyr Ser Met Tyr Ser 
945                 950                 955                 960 


Lys Pro Glu Asp Phe Val Ala Asp Phe Arg Leu Ile Phe Gln Asn Cys 
                965                 970                 975     


Ala Glu Phe Asn Glu Pro Asp Ser Glu Val Ala Asn Ala Gly Ile Lys 
            980                 985                 990         


Leu Glu Asn Tyr Phe Glu Glu Leu  Leu Lys Asn Leu Tyr  Pro Glu Lys 
        995                 1000                 1005             


Arg Phe  Pro Lys Pro Glu Phe  Arg Asn Glu Ser Glu  Asp Asn Lys 
    1010                 1015                 1020             


Phe Ser  Asp Asp Ser Asp Asp  Asp Phe Val Gln Pro  Arg Lys Lys 
    1025                 1030                 1035             


Arg Leu  Lys Ser Ile Glu Glu  Arg Gln Leu Leu Lys  
    1040                 1045                 1050 


<210>  25
<211>  8339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (85)..(3468)

<400>  25
ctgcggctgg ggctgggggc ggcggcggcg gcgacgcggg cggcgggcgg cgcggggcgg       60

tccggcgggt tcaaagagga aaac atg gcg gaa aac aaa ggc ggc ggc gag         111
                           Met Ala Glu Asn Lys Gly Gly Gly Glu            
                           1               5                              

gct gag agc ggc ggc ggg ggc agc ggc agc gcg ccg gta act gcc ggg        159
Ala Glu Ser Gly Gly Gly Gly Ser Gly Ser Ala Pro Val Thr Ala Gly           
10                  15                  20                  25            

gcc gcc ggg ccc gcc gcg cag gag gcg gag ccg cct ctc acc gcg gtg        207
Ala Ala Gly Pro Ala Ala Gln Glu Ala Glu Pro Pro Leu Thr Ala Val           
                30                  35                  40                

ctg gtg gag gag gag gag gag gaa ggc ggc agg gcc ggc gct gag ggc        255
Leu Val Glu Glu Glu Glu Glu Glu Gly Gly Arg Ala Gly Ala Glu Gly           
            45                  50                  55                    

ggc gcg gcc ggg ccc gac gac ggg ggg gtg gcc gcg gcc tcc tcg ggc        303
Gly Ala Ala Gly Pro Asp Asp Gly Gly Val Ala Ala Ala Ser Ser Gly           
        60                  65                  70                        

tcg gcc cag gct gct tca tct cct gcg gcc tca gtg ggc act gga gtt        351
Ser Ala Gln Ala Ala Ser Ser Pro Ala Ala Ser Val Gly Thr Gly Val           
    75                  80                  85                            

gcc ggg ggc gca gta tcg acg ccg gct cca gct cca gcc tcg gct ccc        399
Ala Gly Gly Ala Val Ser Thr Pro Ala Pro Ala Pro Ala Ser Ala Pro           
90                  95                  100                 105           

gct ccg ggt ccc tcg gca ggg ccg cct cct gga ccg cca gcc tcg ctc        447
Ala Pro Gly Pro Ser Ala Gly Pro Pro Pro Gly Pro Pro Ala Ser Leu           
                110                 115                 120               

ctg gac acc tgc gcc gtg tgt cag cag agc ttg cag agc cgg cgt gag        495
Leu Asp Thr Cys Ala Val Cys Gln Gln Ser Leu Gln Ser Arg Arg Glu           
            125                 130                 135                   

gcg gag ccc aag ctg ctg ccc tgt ctt cac tcc ttc tgc ctg cgc tgc        543
Ala Glu Pro Lys Leu Leu Pro Cys Leu His Ser Phe Cys Leu Arg Cys           
        140                 145                 150                       

ctg ccc gag ccg gag cgc cag ctc agc gtg ccc atc ccg ggg ggc agc        591
Leu Pro Glu Pro Glu Arg Gln Leu Ser Val Pro Ile Pro Gly Gly Ser           
    155                 160                 165                           

aac ggc gac atc cag caa gtt ggt gta ata cgg tgc cca gta tgc cgc        639
Asn Gly Asp Ile Gln Gln Val Gly Val Ile Arg Cys Pro Val Cys Arg           
170                 175                 180                 185           

caa gaa tgc aga cag ata gac ctt gtg gat aat tat ttt gtg aaa gac        687
Gln Glu Cys Arg Gln Ile Asp Leu Val Asp Asn Tyr Phe Val Lys Asp           
                190                 195                 200               

aca tct gaa gct cct agc agt tct gat gaa aaa tca gaa cag gta tgt        735
Thr Ser Glu Ala Pro Ser Ser Ser Asp Glu Lys Ser Glu Gln Val Cys           
            205                 210                 215                   

act agt tgt gaa gac aat gca agt gca gtt ggc ttt tgt gta gaa tgt        783
Thr Ser Cys Glu Asp Asn Ala Ser Ala Val Gly Phe Cys Val Glu Cys           
        220                 225                 230                       

gga gag tgg cta tgt aag aca tgt atc gaa gca cat caa aga gta aaa        831
Gly Glu Trp Leu Cys Lys Thr Cys Ile Glu Ala His Gln Arg Val Lys           
    235                 240                 245                           

ttt act aaa gat cac ttg atc agg aag aaa gaa gat gtc tca gag tct        879
Phe Thr Lys Asp His Leu Ile Arg Lys Lys Glu Asp Val Ser Glu Ser           
250                 255                 260                 265           

gtt gga gca tct ggt caa cgc cct gtt ttc tgc cct gta cac aaa caa        927
Val Gly Ala Ser Gly Gln Arg Pro Val Phe Cys Pro Val His Lys Gln           
                270                 275                 280               

gaa cag ttg aaa ctt ttc tgt gaa aca tgt gat aga ttg aca tgt aga        975
Glu Gln Leu Lys Leu Phe Cys Glu Thr Cys Asp Arg Leu Thr Cys Arg           
            285                 290                 295                   

gac tgt cag cta ttg gaa cac aaa gaa cat agg tat cag ttt ttg gaa       1023
Asp Cys Gln Leu Leu Glu His Lys Glu His Arg Tyr Gln Phe Leu Glu           
        300                 305                 310                       

gaa gct ttt caa aat cag aag ggt gca att gag aat cta ctg gcg aaa       1071
Glu Ala Phe Gln Asn Gln Lys Gly Ala Ile Glu Asn Leu Leu Ala Lys           
    315                 320                 325                           

ctt ctt gag aag aag aat tat gtt cat ttt gca gct act cag gtg cag       1119
Leu Leu Glu Lys Lys Asn Tyr Val His Phe Ala Ala Thr Gln Val Gln           
330                 335                 340                 345           

aat agg ata aaa gaa gta aat gag act aac aaa cga gta gaa cag gaa       1167
Asn Arg Ile Lys Glu Val Asn Glu Thr Asn Lys Arg Val Glu Gln Glu           
                350                 355                 360               

att aaa gtg gcc att ttc acc ctt atc aat gaa att aat aag aaa gga       1215
Ile Lys Val Ala Ile Phe Thr Leu Ile Asn Glu Ile Asn Lys Lys Gly           
            365                 370                 375                   

aaa tct ctc tta caa cag cta gag aat gtt aca aag gaa aga cag atg       1263
Lys Ser Leu Leu Gln Gln Leu Glu Asn Val Thr Lys Glu Arg Gln Met           
        380                 385                 390                       

aag tta cta cag cag cag aat gac atc aca ggc ctt tcc cgg cag gtg       1311
Lys Leu Leu Gln Gln Gln Asn Asp Ile Thr Gly Leu Ser Arg Gln Val           
    395                 400                 405                           

aag cat gtt atg aac ttc aca aat tgg gca att gca agt ggc agc agc       1359
Lys His Val Met Asn Phe Thr Asn Trp Ala Ile Ala Ser Gly Ser Ser           
410                 415                 420                 425           

aca gca cta cta tac agc aag cga ctg att act ttc cag ttg cgt cat       1407
Thr Ala Leu Leu Tyr Ser Lys Arg Leu Ile Thr Phe Gln Leu Arg His           
                430                 435                 440               

att ttg aaa gca cgg tgt gat cct gtc cct gct gct aat gga gca ata       1455
Ile Leu Lys Ala Arg Cys Asp Pro Val Pro Ala Ala Asn Gly Ala Ile           
            445                 450                 455                   

cgt ttc cat tgt gat ccc acc ttc tgg gca aag aat gta gtc aat tta       1503
Arg Phe His Cys Asp Pro Thr Phe Trp Ala Lys Asn Val Val Asn Leu           
        460                 465                 470                       

ggt aat cta gta ata gag agt aaa cca gct cct ggt tat act cct aat       1551
Gly Asn Leu Val Ile Glu Ser Lys Pro Ala Pro Gly Tyr Thr Pro Asn           
    475                 480                 485                           

gtt gta gtt ggg caa gtt cct cca ggg aca aac cac att agt aaa acc       1599
Val Val Val Gly Gln Val Pro Pro Gly Thr Asn His Ile Ser Lys Thr           
490                 495                 500                 505           

cct gga cag att aac tta gca cag ctt cga ctc cag cac atg caa caa       1647
Pro Gly Gln Ile Asn Leu Ala Gln Leu Arg Leu Gln His Met Gln Gln           
                510                 515                 520               

caa gta tat gca cag aaa cat cag cag ttg caa cag atg agg atg cag       1695
Gln Val Tyr Ala Gln Lys His Gln Gln Leu Gln Gln Met Arg Met Gln           
            525                 530                 535                   

caa cca cca gca cct gta cca act aca aca aca aca aca caa cag cat       1743
Gln Pro Pro Ala Pro Val Pro Thr Thr Thr Thr Thr Thr Gln Gln His           
        540                 545                 550                       

cct aga caa gca gcc cct cag atg tta caa caa cag cct cct cga ttg       1791
Pro Arg Gln Ala Ala Pro Gln Met Leu Gln Gln Gln Pro Pro Arg Leu           
    555                 560                 565                           

atc agt gtg caa aca atg caa aga ggc aac atg aac tgt gga gct ttt       1839
Ile Ser Val Gln Thr Met Gln Arg Gly Asn Met Asn Cys Gly Ala Phe           
570                 575                 580                 585           

caa gcc cat cag atg aga ctg gct cag aat gct gcc aga ata cca ggg       1887
Gln Ala His Gln Met Arg Leu Ala Gln Asn Ala Ala Arg Ile Pro Gly           
                590                 595                 600               

ata ccc agg cac agc ggc cct caa tat tcc atg atg cag cca cac ctc       1935
Ile Pro Arg His Ser Gly Pro Gln Tyr Ser Met Met Gln Pro His Leu           
            605                 610                 615                   

caa aga caa cac tca aac cca ggg cat gct gga ccc ttt ccc gta gta       1983
Gln Arg Gln His Ser Asn Pro Gly His Ala Gly Pro Phe Pro Val Val           
        620                 625                 630                       

tcg gta cac aac acc aca atc aac cca acg agc cct act aca gca act       2031
Ser Val His Asn Thr Thr Ile Asn Pro Thr Ser Pro Thr Thr Ala Thr           
    635                 640                 645                           

atg gca aat gca aac cga ggt ccc acc agc cca tct gtt aca gca ata       2079
Met Ala Asn Ala Asn Arg Gly Pro Thr Ser Pro Ser Val Thr Ala Ile           
650                 655                 660                 665           

gag cta atc ccc tca gtt acc aat cca gaa aac ctt cca tcg ctg cca       2127
Glu Leu Ile Pro Ser Val Thr Asn Pro Glu Asn Leu Pro Ser Leu Pro           
                670                 675                 680               

gat att cca ccc ata cag ttg gaa gat gct ggc tca agt agt tta gat       2175
Asp Ile Pro Pro Ile Gln Leu Glu Asp Ala Gly Ser Ser Ser Leu Asp           
            685                 690                 695                   

aat cta cta agt aga tac atc tca ggc agt cac cta ccc cca cag cct       2223
Asn Leu Leu Ser Arg Tyr Ile Ser Gly Ser His Leu Pro Pro Gln Pro           
        700                 705                 710                       

aca agc acc atg aat cct tct cca ggt ccc tct gcc ctt tct ccg gga       2271
Thr Ser Thr Met Asn Pro Ser Pro Gly Pro Ser Ala Leu Ser Pro Gly           
    715                 720                 725                           

tca tca ggt tta tcc aat tct cac aca cct gtg aga ccc cca agt act       2319
Ser Ser Gly Leu Ser Asn Ser His Thr Pro Val Arg Pro Pro Ser Thr           
730                 735                 740                 745           

tct agt act ggc agt cga ggc agc tgt ggg tca tca gga aga act gct       2367
Ser Ser Thr Gly Ser Arg Gly Ser Cys Gly Ser Ser Gly Arg Thr Ala           
                750                 755                 760               

gag aag aca agt ctt agt ttc aaa tct gat cag gtg aag gtc aag caa       2415
Glu Lys Thr Ser Leu Ser Phe Lys Ser Asp Gln Val Lys Val Lys Gln           
            765                 770                 775                   

gaa cct ggg act gaa gat gaa ata tgt agc ttt tca gga ggt gta aaa       2463
Glu Pro Gly Thr Glu Asp Glu Ile Cys Ser Phe Ser Gly Gly Val Lys           
        780                 785                 790                       

caa gaa aaa aca gag gat ggc agg agg agt gct tgc atg ttg agc agt       2511
Gln Glu Lys Thr Glu Asp Gly Arg Arg Ser Ala Cys Met Leu Ser Ser           
    795                 800                 805                           

cct gag agt agc ttg aca cca cct ctc tca acc aac ctg cat cta gaa       2559
Pro Glu Ser Ser Leu Thr Pro Pro Leu Ser Thr Asn Leu His Leu Glu           
810                 815                 820                 825           

agt gaa ttg gat gca ttg gca agc ctg gaa aac cat gtg aaa att gaa       2607
Ser Glu Leu Asp Ala Leu Ala Ser Leu Glu Asn His Val Lys Ile Glu           
                830                 835                 840               

cct gca gat atg aat gaa agc tgc aaa cag tca ggg ctc agc agc ctt       2655
Pro Ala Asp Met Asn Glu Ser Cys Lys Gln Ser Gly Leu Ser Ser Leu           
            845                 850                 855                   

gtt aat gga aag tcc cca att cga agc ctc atg cac agg tcg gca agg       2703
Val Asn Gly Lys Ser Pro Ile Arg Ser Leu Met His Arg Ser Ala Arg           
        860                 865                 870                       

att gga gga gat ggc aac aat aaa gat gat gac cca aat gaa gac tgg       2751
Ile Gly Gly Asp Gly Asn Asn Lys Asp Asp Asp Pro Asn Glu Asp Trp           
    875                 880                 885                           

tgt gct gtc tgc caa aac gga gga gat ctc ttg tgc tgc gaa aaa tgt       2799
Cys Ala Val Cys Gln Asn Gly Gly Asp Leu Leu Cys Cys Glu Lys Cys           
890                 895                 900                 905           

cca aag gtc ttt cat cta act tgt cat gtt cca aca cta ctt agc ttt       2847
Pro Lys Val Phe His Leu Thr Cys His Val Pro Thr Leu Leu Ser Phe           
                910                 915                 920               

cca agt ggg gac tgg ata tgc aca ttt tgt aga gat att gga aag cca       2895
Pro Ser Gly Asp Trp Ile Cys Thr Phe Cys Arg Asp Ile Gly Lys Pro           
            925                 930                 935                   

gaa gtt gaa tat gat tgt gat aat ttg caa cat agt aag aag ggg aaa       2943
Glu Val Glu Tyr Asp Cys Asp Asn Leu Gln His Ser Lys Lys Gly Lys           
        940                 945                 950                       

act gcg cag ggg tta agc ccc gtg gac caa agg aaa tgt gaa cgt ctt       2991
Thr Ala Gln Gly Leu Ser Pro Val Asp Gln Arg Lys Cys Glu Arg Leu           
    955                 960                 965                           

ctg ctt tac ctc tat tgc cat gaa tta agt att gaa ttc cag gag cct       3039
Leu Leu Tyr Leu Tyr Cys His Glu Leu Ser Ile Glu Phe Gln Glu Pro           
970                 975                 980                 985           

gtt cct gct tcg ata cca aac tac tat aaa att ata aag aaa cca  atg      3087
Val Pro Ala Ser Ile Pro Asn Tyr Tyr Lys Ile Ile Lys Lys Pro  Met          
                990                 995                 1000              

gat tta tcc acc  gtg aaa aag aag ctt  cag aaa aaa cat tcc  caa        3132
Asp Leu Ser Thr  Val Lys Lys Lys Leu  Gln Lys Lys His Ser  Gln            
            1005                 1010                 1015                

cac tac caa atc  ccg gat gac ttt gtg  gcc gat gtc cgt ttg  atc        3177
His Tyr Gln Ile  Pro Asp Asp Phe Val  Ala Asp Val Arg Leu  Ile            
            1020                 1025                 1030                

ttc aag aac tgt  gaa agg ttt aat gaa  atg atg aaa gtt gtt  caa        3222
Phe Lys Asn Cys  Glu Arg Phe Asn Glu  Met Met Lys Val Val  Gln            
            1035                 1040                 1045                

gtt tat gca gac  aca caa gag att aat  ttg aag gct gat tca  gaa        3267
Val Tyr Ala Asp  Thr Gln Glu Ile Asn  Leu Lys Ala Asp Ser  Glu            
            1050                 1055                 1060                

gta gct cag gca  ggg aaa gca gtt gca  ttg tac ttt gaa gat  aaa        3312
Val Ala Gln Ala  Gly Lys Ala Val Ala  Leu Tyr Phe Glu Asp  Lys            
            1065                 1070                 1075                

ctc aca gag atc  tac tca gac agg acc  ttc gca cct ttg cca  gag        3357
Leu Thr Glu Ile  Tyr Ser Asp Arg Thr  Phe Ala Pro Leu Pro  Glu            
            1080                 1085                 1090                

ttt gag cag gaa  gag gat gat ggt gag  gta act gag gac tct  gat        3402
Phe Glu Gln Glu  Glu Asp Asp Gly Glu  Val Thr Glu Asp Ser  Asp            
            1095                 1100                 1105                

gaa gac ttt ata  cag ccc cgc aga aaa  cgc cta aag tca gat  gag        3447
Glu Asp Phe Ile  Gln Pro Arg Arg Lys  Arg Leu Lys Ser Asp  Glu            
            1110                 1115                 1120                

aga cca gta cat  ata aag taa aatgacatgg atttaaatca attgtttaaa         3498
Arg Pro Val His  Ile Lys                                                  
            1125                                                          

aaaaaaaaaa cgaaaaaaaa aaaaaaaaca caaaaaaccc agaaaacttt taagtgttgc     3558

tggaatatcc tgcctacagt gggcacctcc ttgaagaagc tgatagcttt tacacagtat     3618

tagattgaaa taatggacag aaacacattc ttgtcaagaa agggggagag aagtctgttt     3678

gcaagtttca aagcaaaaag caaaagtgaa atgatttgag gatttctgtt ctaatggaga     3738

tgattctctg attgttagaa atggcaaata ttgatgattg tgtgctattg attggtgcag     3798

gatacttggt atacgagtaa atacttgaga ctcgtgtcac ttgataaatt ttctttttgg     3858

actaggtcgc acagttatta aaacaacttt taaccctccc ccttcacaca catacatatc     3918

aggttgtttt ctagttaaaa acccaagtag ctcagattct actttaatgt cagtgcagat     3978

ttgcattgaa tcatgccatt atgttttttc tcatttttat gctgttgggt cttagttttt     4038

aaattgatat aaagaactca gcaatggttt tattttctac tcatacttag ggtttaggaa     4098

acactaccac tagttatcat ttaatcaact tcaatggtct actgaaacaa aaatggtaac     4158

ttttcattag tggattattt agagttatag tagttgtttc cagaaaacac ttcctcacaa     4218

ttgtacttcc caatcaaatc atgtgatcat acagttattc ccatgaaagg cagaatgttt     4278

gtttcaaaat taatctagtt ttctgtacat ttaaatttga gaaggtgaca actggctctt     4338

ttccagtctt ccttcatgtc agttttctga tagaccacta ttggcaaaca gtatctgtca     4398

actaccaaat gtgtaaaatt ttctgtattt cactttgtct tatttgtaaa tagtgaacta     4458

aaacttttgg cagatcagca acatttgctg agcctgtttt ttaagctaat gtgtattctt     4518

actaatgttc ctatcaagaa tggatttgta atatatgctg tctatttcta atgttcacat     4578

tcatattttg aggttctatc ttattttaat agagaacaga cttctcaaaa aatcttcaga     4638

agcagcttat tattgaaata tcgaaatatt gaaataaacc cggtggggtt agattactca     4698

tctgtccacc aagtgggaca tttgcatgga ctgggggctt aaaggactta gaagagacct     4758

gtaagtaaat cctgaaaatg agccaatccc cacttgaatg gttactggag taaacccacc     4818

tttaccaccc caattacagc acccgaggcc gataaaccaa cttggctctg gttcattttt     4878

cttttcttca tttgtgatgc tcagattcaa aatgtgtgtt ctacactgtt acaggcttct     4938

cttttgtttg attaaagatt ttagtcctac ttttgtatgg acacattaga atattcagag     4998

accaaaatag aagaatttgc tgttagatat ttttcagaag tcagcagatt tgtggcaaat     5058

catttatttg cctttttaaa aattcattta agcagttcag agagtagact actcagaaaa     5118

ttatttcacg taattgtcta agaggtcaat attttttaat gcatattgaa tcaaataaag     5178

tgctctaaag aaattattat acaaattcct ttgggttgtt tttcttttct taacaagggg     5238

tgggggtaaa caggaatatg attcaggctt tctggttgtg tatttaaaga gtattgattt     5298

tattattact attgatttac tttattcctg gcttcctttt cacttttctt tcaattttta     5358

aaaaataatt taagccgttg aaaatatacc aaactgttga aacattttac tcaaatttta     5418

aattcctaaa aatgtttttt aataagaggg agaaaattat ttaaaaatac ttatgcctat     5478

gccaatttcc ctcttttttc acaaaatcca tgatttcagt ttgtaagtag acatatatct     5538

aagggcacat ttttggaaag tgaggaatag cagcagtata acttcatttt gtcaggcctt     5598

tgagttctaa tattttgtat tgctcttcaa atggatcctt ttaaaaaaat tgtagataat     5658

gagtcataaa tagattctgc caactgaggg gagaaacatt ttaagtaaat atttttcagt     5718

atttggggcc ttaaaaaata attgtgtttc cttaaaatta catgttagat agagttttta     5778

ggtttttttg gttttaagat tggttaaagc aatttaaaag ccactttttt gtcaacattt     5838

aatagcctcc acttctgtta agataatgta tactgctgag gaattactat taatagctat     5898

caacatacca ccattaaatt aaggtattca ctttagattt tttattaaag cttttttctt     5958

gcacactgat cgttgtgttt ctaagctgat tttttcagct ctaatatacc tatggttaaa     6018

aagtataaaa acttaaattg atatttagat atatgttttc ctattagttt atgttttaaa     6078

aagacaaaat tgtatctgtc agtccctgaa ggcagtttgt ttttatactc tctcacattt     6138

gtatttgttt tttaaatggc agtattttag aagatttgga gaaaagtcca cataataatg     6198

ttttcttaaa agcttttaaa gtttttgctg tacttcaatt tacttcttcc atcagaaaac     6258

taagaacaaa gtgttgctca gtctgttccg ctgacctaaa tttgtgtttt cagcacttgg     6318

ctcagccaat tcactgagtg aaggaattgc tttatgaggc aaagcatgtg aaagttctaa     6378

agtatggtta gattgtaggt cgtgctctat atggaaacat caaaccatta ctacagagaa     6438

atgataaggc attggatcca ctattgaaat tattattttt ggatcaacaa gttggtactt     6498

tctgacttct gtatcttaac ataagggaat tttaggtaat gctaagtcag ttgtctcatt     6558

ttttgtgata agttttggaa tttttagtta attgaaataa ataatgcttt taaatagaag     6618

taaaaggttt ataagtgtgc aaattgtaga tttatcaatt acctcagcag gtatcctgcc     6678

atgtaattat tagtgattag tgttaataag ataatagatt caggtcttcc aactatgccc     6738

ttggattgtg gcctactgta tgttattaaa tggtctctta ctatccaaaa tgggagtaga     6798

tgctgtggcc ccgtctccct tggcttttac gtcccatatc cacccccatt catgtacaac     6858

atgtgaaata taaaaatctc atttcttgtc aaaatcagca ctgcttattt gcatactcag     6918

catcggatca gtgagtagtt ttataaaaaa tccacgcacc caactccctt agttaaaaca     6978

gattcttaat tcataccatg aattcttaat ttctgtacca tctatgttaa tgatctgctg     7038

aaggtgactc aagattttca aggtgtaata cagtttgatc atgtaccgga cctggatatt     7098

taattttttt tccctcacag ttaatctcct ccttgataaa gcaataacac tgctttgagt     7158

ctgttgccta atagcatgtc agaatcctct cctggatggt gattttatag gaaagtttgt     7218

atgcatatca cccagtctat cttttaaaaa ttaagaaatt taaatgtatg ctggaagtaa     7278

tgacactata ttgtggcatt ttattttaaa aattggggaa agttgcatat ttttttaaaa     7338

gtaagtgttt gagtaaaaaa attgaaggta cttttttaag gaaaaaaatt tatatgccac     7398

agtttacata gacatttcag attcaacacg tactcttgaa tataatggtt tcttttactt     7458

ggtcaaaatg catgtatagc atttctttca tcttagttcc ttgtgtttgc ctatgtggtc     7518

ctttatatat tttttattgt atcgaagaaa caaaactatc ttcaaaaata agttaatttg     7578

gatatatttg tcatatcaaa ctacaaagtg tacaaagtta agtttagccc ttttctagaa     7638

agtgatcttt aaaattaaaa atgctcctct tttaaattca ccaaatttat gtgtgggaag     7698

gcaccaaaat gattttgtaa gtgccactgc aatattccct ttcaagtgtg gcctaaattt     7758

caatcttaag gatggaatgc atgtctgctc cttgttctga aaaatgtagg catctactac     7818

attttaaaac acagtgaaac atatacataa gcctataaaa aaagatttgt gcaatttgaa     7878

agcctgttaa ttttttatgt agacatacct acacacgaaa gggttaaatt cacagcctta     7938

ctagttcctt gcttccagta tttcaattgg tctcctcccc tcattattat tattactact     7998

agtactatta tttttgcaca tagttaactg cccttcaata tgattcttaa aaagtgctgt     8058

ttctgtggta tcgtattctc taaataatca tatttaattt tttaaaacaa ggttgcagtt     8118

tctaattgtt tcgttcctgt gtttttgctg gtgtgtaata aaagcaagtt ttttcttttc     8178

atggttattt aatacattag ctgcctgtaa ataattcttg ttataatgct ctggaatgtg     8238

ttgtagaagt tgtattagat tagttttaaa cccttgtttg aaagccacat tgttttggtt     8298

atttctatta aattagaaaa ttgaaaaagt tttcaaatga a                         8339


<210>  26
<211>  1127
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Glu Asn Lys Gly Gly Gly Glu Ala Glu Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ser Ala Pro Val Thr Ala Gly Ala Ala Gly Pro Ala Ala Gln 
            20                  25                  30          


Glu Ala Glu Pro Pro Leu Thr Ala Val Leu Val Glu Glu Glu Glu Glu 
        35                  40                  45              


Glu Gly Gly Arg Ala Gly Ala Glu Gly Gly Ala Ala Gly Pro Asp Asp 
    50                  55                  60                  


Gly Gly Val Ala Ala Ala Ser Ser Gly Ser Ala Gln Ala Ala Ser Ser 
65                  70                  75                  80  


Pro Ala Ala Ser Val Gly Thr Gly Val Ala Gly Gly Ala Val Ser Thr 
                85                  90                  95      


Pro Ala Pro Ala Pro Ala Ser Ala Pro Ala Pro Gly Pro Ser Ala Gly 
            100                 105                 110         


Pro Pro Pro Gly Pro Pro Ala Ser Leu Leu Asp Thr Cys Ala Val Cys 
        115                 120                 125             


Gln Gln Ser Leu Gln Ser Arg Arg Glu Ala Glu Pro Lys Leu Leu Pro 
    130                 135                 140                 


Cys Leu His Ser Phe Cys Leu Arg Cys Leu Pro Glu Pro Glu Arg Gln 
145                 150                 155                 160 


Leu Ser Val Pro Ile Pro Gly Gly Ser Asn Gly Asp Ile Gln Gln Val 
                165                 170                 175     


Gly Val Ile Arg Cys Pro Val Cys Arg Gln Glu Cys Arg Gln Ile Asp 
            180                 185                 190         


Leu Val Asp Asn Tyr Phe Val Lys Asp Thr Ser Glu Ala Pro Ser Ser 
        195                 200                 205             


Ser Asp Glu Lys Ser Glu Gln Val Cys Thr Ser Cys Glu Asp Asn Ala 
    210                 215                 220                 


Ser Ala Val Gly Phe Cys Val Glu Cys Gly Glu Trp Leu Cys Lys Thr 
225                 230                 235                 240 


Cys Ile Glu Ala His Gln Arg Val Lys Phe Thr Lys Asp His Leu Ile 
                245                 250                 255     


Arg Lys Lys Glu Asp Val Ser Glu Ser Val Gly Ala Ser Gly Gln Arg 
            260                 265                 270         


Pro Val Phe Cys Pro Val His Lys Gln Glu Gln Leu Lys Leu Phe Cys 
        275                 280                 285             


Glu Thr Cys Asp Arg Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His 
    290                 295                 300                 


Lys Glu His Arg Tyr Gln Phe Leu Glu Glu Ala Phe Gln Asn Gln Lys 
305                 310                 315                 320 


Gly Ala Ile Glu Asn Leu Leu Ala Lys Leu Leu Glu Lys Lys Asn Tyr 
                325                 330                 335     


Val His Phe Ala Ala Thr Gln Val Gln Asn Arg Ile Lys Glu Val Asn 
            340                 345                 350         


Glu Thr Asn Lys Arg Val Glu Gln Glu Ile Lys Val Ala Ile Phe Thr 
        355                 360                 365             


Leu Ile Asn Glu Ile Asn Lys Lys Gly Lys Ser Leu Leu Gln Gln Leu 
    370                 375                 380                 


Glu Asn Val Thr Lys Glu Arg Gln Met Lys Leu Leu Gln Gln Gln Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Leu Ser Arg Gln Val Lys His Val Met Asn Phe Thr 
                405                 410                 415     


Asn Trp Ala Ile Ala Ser Gly Ser Ser Thr Ala Leu Leu Tyr Ser Lys 
            420                 425                 430         


Arg Leu Ile Thr Phe Gln Leu Arg His Ile Leu Lys Ala Arg Cys Asp 
        435                 440                 445             


Pro Val Pro Ala Ala Asn Gly Ala Ile Arg Phe His Cys Asp Pro Thr 
    450                 455                 460                 


Phe Trp Ala Lys Asn Val Val Asn Leu Gly Asn Leu Val Ile Glu Ser 
465                 470                 475                 480 


Lys Pro Ala Pro Gly Tyr Thr Pro Asn Val Val Val Gly Gln Val Pro 
                485                 490                 495     


Pro Gly Thr Asn His Ile Ser Lys Thr Pro Gly Gln Ile Asn Leu Ala 
            500                 505                 510         


Gln Leu Arg Leu Gln His Met Gln Gln Gln Val Tyr Ala Gln Lys His 
        515                 520                 525             


Gln Gln Leu Gln Gln Met Arg Met Gln Gln Pro Pro Ala Pro Val Pro 
    530                 535                 540                 


Thr Thr Thr Thr Thr Thr Gln Gln His Pro Arg Gln Ala Ala Pro Gln 
545                 550                 555                 560 


Met Leu Gln Gln Gln Pro Pro Arg Leu Ile Ser Val Gln Thr Met Gln 
                565                 570                 575     


Arg Gly Asn Met Asn Cys Gly Ala Phe Gln Ala His Gln Met Arg Leu 
            580                 585                 590         


Ala Gln Asn Ala Ala Arg Ile Pro Gly Ile Pro Arg His Ser Gly Pro 
        595                 600                 605             


Gln Tyr Ser Met Met Gln Pro His Leu Gln Arg Gln His Ser Asn Pro 
    610                 615                 620                 


Gly His Ala Gly Pro Phe Pro Val Val Ser Val His Asn Thr Thr Ile 
625                 630                 635                 640 


Asn Pro Thr Ser Pro Thr Thr Ala Thr Met Ala Asn Ala Asn Arg Gly 
                645                 650                 655     


Pro Thr Ser Pro Ser Val Thr Ala Ile Glu Leu Ile Pro Ser Val Thr 
            660                 665                 670         


Asn Pro Glu Asn Leu Pro Ser Leu Pro Asp Ile Pro Pro Ile Gln Leu 
        675                 680                 685             


Glu Asp Ala Gly Ser Ser Ser Leu Asp Asn Leu Leu Ser Arg Tyr Ile 
    690                 695                 700                 


Ser Gly Ser His Leu Pro Pro Gln Pro Thr Ser Thr Met Asn Pro Ser 
705                 710                 715                 720 


Pro Gly Pro Ser Ala Leu Ser Pro Gly Ser Ser Gly Leu Ser Asn Ser 
                725                 730                 735     


His Thr Pro Val Arg Pro Pro Ser Thr Ser Ser Thr Gly Ser Arg Gly 
            740                 745                 750         


Ser Cys Gly Ser Ser Gly Arg Thr Ala Glu Lys Thr Ser Leu Ser Phe 
        755                 760                 765             


Lys Ser Asp Gln Val Lys Val Lys Gln Glu Pro Gly Thr Glu Asp Glu 
    770                 775                 780                 


Ile Cys Ser Phe Ser Gly Gly Val Lys Gln Glu Lys Thr Glu Asp Gly 
785                 790                 795                 800 


Arg Arg Ser Ala Cys Met Leu Ser Ser Pro Glu Ser Ser Leu Thr Pro 
                805                 810                 815     


Pro Leu Ser Thr Asn Leu His Leu Glu Ser Glu Leu Asp Ala Leu Ala 
            820                 825                 830         


Ser Leu Glu Asn His Val Lys Ile Glu Pro Ala Asp Met Asn Glu Ser 
        835                 840                 845             


Cys Lys Gln Ser Gly Leu Ser Ser Leu Val Asn Gly Lys Ser Pro Ile 
    850                 855                 860                 


Arg Ser Leu Met His Arg Ser Ala Arg Ile Gly Gly Asp Gly Asn Asn 
865                 870                 875                 880 


Lys Asp Asp Asp Pro Asn Glu Asp Trp Cys Ala Val Cys Gln Asn Gly 
                885                 890                 895     


Gly Asp Leu Leu Cys Cys Glu Lys Cys Pro Lys Val Phe His Leu Thr 
            900                 905                 910         


Cys His Val Pro Thr Leu Leu Ser Phe Pro Ser Gly Asp Trp Ile Cys 
        915                 920                 925             


Thr Phe Cys Arg Asp Ile Gly Lys Pro Glu Val Glu Tyr Asp Cys Asp 
    930                 935                 940                 


Asn Leu Gln His Ser Lys Lys Gly Lys Thr Ala Gln Gly Leu Ser Pro 
945                 950                 955                 960 


Val Asp Gln Arg Lys Cys Glu Arg Leu Leu Leu Tyr Leu Tyr Cys His 
                965                 970                 975     


Glu Leu Ser Ile Glu Phe Gln Glu Pro Val Pro Ala Ser Ile Pro Asn 
            980                 985                 990         


Tyr Tyr Lys Ile Ile Lys Lys Pro  Met Asp Leu Ser Thr  Val Lys Lys 
        995                 1000                 1005             


Lys Leu  Gln Lys Lys His Ser  Gln His Tyr Gln Ile  Pro Asp Asp 
    1010                 1015                 1020             


Phe Val  Ala Asp Val Arg Leu  Ile Phe Lys Asn Cys  Glu Arg Phe 
    1025                 1030                 1035             


Asn Glu  Met Met Lys Val Val  Gln Val Tyr Ala Asp  Thr Gln Glu 
    1040                 1045                 1050             


Ile Asn  Leu Lys Ala Asp Ser  Glu Val Ala Gln Ala  Gly Lys Ala 
    1055                 1060                 1065             


Val Ala  Leu Tyr Phe Glu Asp  Lys Leu Thr Glu Ile  Tyr Ser Asp 
    1070                 1075                 1080             


Arg Thr  Phe Ala Pro Leu Pro  Glu Phe Glu Gln Glu  Glu Asp Asp 
    1085                 1090                 1095             


Gly Glu  Val Thr Glu Asp Ser  Asp Glu Asp Phe Ile  Gln Pro Arg 
    1100                 1105                 1110             


Arg Lys  Arg Leu Lys Ser Asp  Glu Arg Pro Val His  Ile Lys 
    1115                 1120                 1125         


<210>  27
<211>  4526
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (167)..(3361)

<400>  27
acggctgcgc agatgccgac tttagaggag gcggagtttc ggccttcgcc tgctggaaaa       60

gcagtaggat cggccagtgg cgacagcagg agctgagcct aagccctggc ggggctttgg      120

gctgtagatt cctgtctgac taaagggacc tcaaaaagga gggaaa atg gct tct         175
                                                   Met Ala Ser            
                                                   1                      

gag tct gaa act ctg aat ccc agt gct agg ata atg acc ttt tat cca        223
Glu Ser Glu Thr Leu Asn Pro Ser Ala Arg Ile Met Thr Phe Tyr Pro           
    5                   10                  15                            

act atg gaa gag ttc cga aac ttc agt aga tac att gcc tac att gaa        271
Thr Met Glu Glu Phe Arg Asn Phe Ser Arg Tyr Ile Ala Tyr Ile Glu           
20                  25                  30                  35            

tcc caa gga gct cat cgg gca ggg cta gcc aag gtt gtt cct cca aaa        319
Ser Gln Gly Ala His Arg Ala Gly Leu Ala Lys Val Val Pro Pro Lys           
                40                  45                  50                

gag tgg aag cca cga gca tcc tat gat gac att gat gat ttg gtc att        367
Glu Trp Lys Pro Arg Ala Ser Tyr Asp Asp Ile Asp Asp Leu Val Ile           
            55                  60                  65                    

cct gcc ccc att caa cag ctg gtg acg ggg cag tct ggc ctc ttt act        415
Pro Ala Pro Ile Gln Gln Leu Val Thr Gly Gln Ser Gly Leu Phe Thr           
        70                  75                  80                        

cag tac aac ata cag aag aaa gcc atg act gtt cga gag ttc cgc aag        463
Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val Arg Glu Phe Arg Lys           
    85                  90                  95                            

ata gcc aat agc gat aag tac tgt acc cca cgc tat agt gag ttt gaa        511
Ile Ala Asn Ser Asp Lys Tyr Cys Thr Pro Arg Tyr Ser Glu Phe Glu           
100                 105                 110                 115           

gag ctc gag cgg aaa tac tgg aaa aat ctt aca ttc aat cct cca atc        559
Glu Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr Phe Asn Pro Pro Ile           
                120                 125                 130               

tat ggt gca gat gtg aat ggt acc ctc tat gaa aag cat gtt gat gag        607
Tyr Gly Ala Asp Val Asn Gly Thr Leu Tyr Glu Lys His Val Asp Glu           
            135                 140                 145                   

tgg aat att ggc cgg ctg aga aca atc ctg gac ttg gtg gaa aag gag        655
Trp Asn Ile Gly Arg Leu Arg Thr Ile Leu Asp Leu Val Glu Lys Glu           
        150                 155                 160                       

agt ggg atc acc att gag ggt gtg aac acc cca tac ctg tac ttt ggc        703
Ser Gly Ile Thr Ile Glu Gly Val Asn Thr Pro Tyr Leu Tyr Phe Gly           
    165                 170                 175                           

atg tgg aag aca tcc ttt gct tgg cac act gaa gac atg gac ctc tac        751
Met Trp Lys Thr Ser Phe Ala Trp His Thr Glu Asp Met Asp Leu Tyr           
180                 185                 190                 195           

agc atc aac tac ctg cac ttt gga gaa cca aag tcc tgg tac tct gtt        799
Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys Ser Trp Tyr Ser Val           
                200                 205                 210               

cca cct gag cat gga aag cgg ttg gaa cgc ctc gcc aaa ggc ttt ttc        847
Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu Ala Lys Gly Phe Phe           
            215                 220                 225                   

cca gga agt gct caa agc tgt gag gca ttt ctc cgc cac aag atg acc        895
Pro Gly Ser Ala Gln Ser Cys Glu Ala Phe Leu Arg His Lys Met Thr           
        230                 235                 240                       

ctg att tcc ccg tta atg ctg aag aaa tat gga att ccc ttt gac aag        943
Leu Ile Ser Pro Leu Met Leu Lys Lys Tyr Gly Ile Pro Phe Asp Lys           
    245                 250                 255                           

gtg act caa gag gct gga gag ttt atg atc act ttc cct tat ggt tac        991
Val Thr Gln Glu Ala Gly Glu Phe Met Ile Thr Phe Pro Tyr Gly Tyr           
260                 265                 270                 275           

cat gcc ggc ttt aac cat ggt ttt aac tgt gcg gag tct acc aat ttt       1039
His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu Ser Thr Asn Phe           
                280                 285                 290               

gct acc cgt cgg tgg att gag tac ggc aag caa gct gtg ctg tgc tcc       1087
Ala Thr Arg Arg Trp Ile Glu Tyr Gly Lys Gln Ala Val Leu Cys Ser           
            295                 300                 305                   

tgt aga aag gac atg gtg aag atc tcc atg gat gtg ttt gtg aga aag       1135
Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp Val Phe Val Arg Lys           
        310                 315                 320                       

ttc cag cca gaa agg tac aaa ctt tgg aaa gct ggg aag gac aac aca       1183
Phe Gln Pro Glu Arg Tyr Lys Leu Trp Lys Ala Gly Lys Asp Asn Thr           
    325                 330                 335                           

gtt att gac cat act ctg ccc acg cca gaa gca gct gag ttt ctt aag       1231
Val Ile Asp His Thr Leu Pro Thr Pro Glu Ala Ala Glu Phe Leu Lys           
340                 345                 350                 355           

gag agt gaa ctg cct cca aga gct ggc aac gag gag gag tgc cca gag       1279
Glu Ser Glu Leu Pro Pro Arg Ala Gly Asn Glu Glu Glu Cys Pro Glu           
                360                 365                 370               

gag gac atg gaa ggg gtg gag gat gga gag gaa gga gac ctg aag aca       1327
Glu Asp Met Glu Gly Val Glu Asp Gly Glu Glu Gly Asp Leu Lys Thr           
            375                 380                 385                   

agc ctg gcc aag cac cga ata ggg aca aag agg cac cga gtt tgt ctt       1375
Ser Leu Ala Lys His Arg Ile Gly Thr Lys Arg His Arg Val Cys Leu           
        390                 395                 400                       

gaa ata cca cag gag gtg agt cag agt gag ctc ttc ccc aag gag gat       1423
Glu Ile Pro Gln Glu Val Ser Gln Ser Glu Leu Phe Pro Lys Glu Asp           
    405                 410                 415                           

ctg agt tct gag cag tat gag atg acg gag tgc ccg gca gcc ctc gcc       1471
Leu Ser Ser Glu Gln Tyr Glu Met Thr Glu Cys Pro Ala Ala Leu Ala           
420                 425                 430                 435           

cct gtg agg ccc acc cat agc tct gtg cgg caa gtt gag gat ggt ctt       1519
Pro Val Arg Pro Thr His Ser Ser Val Arg Gln Val Glu Asp Gly Leu           
                440                 445                 450               

acc ttc cca gat tat tct gac tcc act gaa gtc aaa ttt gaa gag ctt       1567
Thr Phe Pro Asp Tyr Ser Asp Ser Thr Glu Val Lys Phe Glu Glu Leu           
            455                 460                 465                   

aaa aat gtc aaa cta gaa gag gag gat gag gag gaa gaa caa gca gca       1615
Lys Asn Val Lys Leu Glu Glu Glu Asp Glu Glu Glu Glu Gln Ala Ala           
        470                 475                 480                       

gct gcc ttg gat ctt tct gtg aat cct gcg tct gta ggg gga cgc ctt       1663
Ala Ala Leu Asp Leu Ser Val Asn Pro Ala Ser Val Gly Gly Arg Leu           
    485                 490                 495                           

gtc ttc tca ggc tcc aaa aag aaa tca tct tct agc ctg ggc tct ggc       1711
Val Phe Ser Gly Ser Lys Lys Lys Ser Ser Ser Ser Leu Gly Ser Gly           
500                 505                 510                 515           

tct tca cgg gat tct atc tct tct gat tca gaa act agt gag cct ctc       1759
Ser Ser Arg Asp Ser Ile Ser Ser Asp Ser Glu Thr Ser Glu Pro Leu           
                520                 525                 530               

tcc tgc cga gcc caa ggg caa acg gga gtt ctc act gtg cac agt tat       1807
Ser Cys Arg Ala Gln Gly Gln Thr Gly Val Leu Thr Val His Ser Tyr           
            535                 540                 545                   

gcc aaa ggg gat ggc agg gtc act gtg gga gag cca tgc acg agg aag       1855
Ala Lys Gly Asp Gly Arg Val Thr Val Gly Glu Pro Cys Thr Arg Lys           
        550                 555                 560                       

aaa gga agc gcc gct aga agt ttc agt gag cgg gag ctg gca gag gtt       1903
Lys Gly Ser Ala Ala Arg Ser Phe Ser Glu Arg Glu Leu Ala Glu Val           
    565                 570                 575                           

gca gat gaa tac atg ttt tcc cta gaa gag aat aag aag tcc aag gga       1951
Ala Asp Glu Tyr Met Phe Ser Leu Glu Glu Asn Lys Lys Ser Lys Gly           
580                 585                 590                 595           

cgc cgt cag cct tta agc aag ctc ccc cgc cat cac cca ctt gtg ctg       1999
Arg Arg Gln Pro Leu Ser Lys Leu Pro Arg His His Pro Leu Val Leu           
                600                 605                 610               

cag gag tgt gtc agt gat gat gag aca tct gaa cag ctg acc cct gag       2047
Gln Glu Cys Val Ser Asp Asp Glu Thr Ser Glu Gln Leu Thr Pro Glu           
            615                 620                 625                   

gaa gag gct gag gag aca gag gcc tgg gcc aag cct ctg agc caa ctg       2095
Glu Glu Ala Glu Glu Thr Glu Ala Trp Ala Lys Pro Leu Ser Gln Leu           
        630                 635                 640                       

tgg cag aac cga cct cca aac ttt gag gct gag aag gaa ttc aat gag       2143
Trp Gln Asn Arg Pro Pro Asn Phe Glu Ala Glu Lys Glu Phe Asn Glu           
    645                 650                 655                           

acc atg gcc caa cag gcc cct cac tgc gct gtc tgt atg atc ttc cag       2191
Thr Met Ala Gln Gln Ala Pro His Cys Ala Val Cys Met Ile Phe Gln           
660                 665                 670                 675           

act tat cat cag gtt gaa ttt gga ggc ttt aat cag aac tgt gga aat       2239
Thr Tyr His Gln Val Glu Phe Gly Gly Phe Asn Gln Asn Cys Gly Asn           
                680                 685                 690               

gct tca gat tta gcc ccc cag aag cag agg acc aag cca ttg att cca       2287
Ala Ser Asp Leu Ala Pro Gln Lys Gln Arg Thr Lys Pro Leu Ile Pro           
            695                 700                 705                   

gaa atg tgc ttc act tcg act ggc tgc agc acg gac atc aac ctt tct       2335
Glu Met Cys Phe Thr Ser Thr Gly Cys Ser Thr Asp Ile Asn Leu Ser           
        710                 715                 720                       

act cct tat ctt gag gag gat ggc acc agc ata ctc gtt tcc tgc aag       2383
Thr Pro Tyr Leu Glu Glu Asp Gly Thr Ser Ile Leu Val Ser Cys Lys           
    725                 730                 735                           

aag tgc agc gtc cgg gtc cat gcc agt tgc tat ggg gtc ccc cct gca       2431
Lys Cys Ser Val Arg Val His Ala Ser Cys Tyr Gly Val Pro Pro Ala           
740                 745                 750                 755           

aag gct tct gaa gac tgg atg tgt tct cgg tgt tca gcc aat gcc cta       2479
Lys Ala Ser Glu Asp Trp Met Cys Ser Arg Cys Ser Ala Asn Ala Leu           
                760                 765                 770               

gag gag gac tgc tgt tta tgc tca tta cga gga ggg gcc ctg cag aga       2527
Glu Glu Asp Cys Cys Leu Cys Ser Leu Arg Gly Gly Ala Leu Gln Arg           
            775                 780                 785                   

gca aat gat gac agg tgg gtc cac gtt tca tgt gct gtg gca att ctg       2575
Ala Asn Asp Asp Arg Trp Val His Val Ser Cys Ala Val Ala Ile Leu           
        790                 795                 800                       

gaa gca agg ttt gtc aac att gca gaa aga agt ccg gtg gat gtg agc       2623
Glu Ala Arg Phe Val Asn Ile Ala Glu Arg Ser Pro Val Asp Val Ser           
    805                 810                 815                           

aaa atc ccc ctg ccc cgc ttc aaa ctg aaa tgt atc ttc tgt aag aag       2671
Lys Ile Pro Leu Pro Arg Phe Lys Leu Lys Cys Ile Phe Cys Lys Lys           
820                 825                 830                 835           

cgg agg aaa aga act gct ggc tgc tgt gtg cag tgt tct cac ggc cgc       2719
Arg Arg Lys Arg Thr Ala Gly Cys Cys Val Gln Cys Ser His Gly Arg           
                840                 845                 850               

tgc cca act gcc ttc cat gtg agc tgc gcc cag gct gcc ggt gtg atg       2767
Cys Pro Thr Ala Phe His Val Ser Cys Ala Gln Ala Ala Gly Val Met           
            855                 860                 865                   

atg cag cct gac gac tgg cct ttt gtg gtc ttc att acc tgc ttt cgg       2815
Met Gln Pro Asp Asp Trp Pro Phe Val Val Phe Ile Thr Cys Phe Arg           
        870                 875                 880                       

cac aag att cct aat ttg gag cgt gcc aag ggg gcc ttg caa agc atc       2863
His Lys Ile Pro Asn Leu Glu Arg Ala Lys Gly Ala Leu Gln Ser Ile           
    885                 890                 895                           

act gca ggc cag aaa gtc att agc aag cat aag aac ggg cgc ttc tac       2911
Thr Ala Gly Gln Lys Val Ile Ser Lys His Lys Asn Gly Arg Phe Tyr           
900                 905                 910                 915           

cag tgt gaa gtg gtc agg ctc acc acc gag acc ttc tat gaa gtc aac       2959
Gln Cys Glu Val Val Arg Leu Thr Thr Glu Thr Phe Tyr Glu Val Asn           
                920                 925                 930               

ttt gat gat ggc tcc ttc agc gac aat ctt tat cct gag gac ata gtg       3007
Phe Asp Asp Gly Ser Phe Ser Asp Asn Leu Tyr Pro Glu Asp Ile Val           
            935                 940                 945                   

agc cag gac tgt ctc cag ttt ggt cct cct gct gaa ggg gaa gtg gtc       3055
Ser Gln Asp Cys Leu Gln Phe Gly Pro Pro Ala Glu Gly Glu Val Val           
        950                 955                 960                       

caa gtg aga tgg aca gac ggc caa gtc tat gga gcc aag ttt gtg gcc       3103
Gln Val Arg Trp Thr Asp Gly Gln Val Tyr Gly Ala Lys Phe Val Ala           
    965                 970                 975                           

tcc cac cct atc caa atg tac cag gtg gag ttt gag gat ggc tca caa       3151
Ser His Pro Ile Gln Met Tyr Gln Val Glu Phe Glu Asp Gly Ser Gln           
980                 985                 990                 995           

ctt gtg gtt aag aga  gat gat gta tac aca  ctg gat gaa gag ctt         3196
Leu Val Val Lys Arg  Asp Asp Val Tyr Thr  Leu Asp Glu Glu Leu             
                1000                 1005                 1010            

ccc aag aga gtc aaa  tct aga ctg tca gta  gcc tca gac atg cgc         3241
Pro Lys Arg Val Lys  Ser Arg Leu Ser Val  Ala Ser Asp Met Arg             
                1015                 1020                 1025            

ttc aat gag att ttc  aca gag aaa gag gtt  aag caa gaa aag aaa         3286
Phe Asn Glu Ile Phe  Thr Glu Lys Glu Val  Lys Gln Glu Lys Lys             
                1030                 1035                 1040            

cgg caa cga gtt atc  aac tca aga tac cgg  gaa gat tat att gag         3331
Arg Gln Arg Val Ile  Asn Ser Arg Tyr Arg  Glu Asp Tyr Ile Glu             
                1045                 1050                 1055            

cct gca cta tac cgg  gcc atc atg gag tag gtgcttccag ggtccaaggg        3381
Pro Ala Leu Tyr Arg  Ala Ile Met Glu                                      
                1060                                                      

attctcagcc atccaggcaa gagcactctg ggttccacag cacagcagac atggaacgct     3441

gaagtctctg aaagtgaagt tgtaaaaaga aaaggaatga aataaccgac ccatcatctt     3501

ctcacccacc ctcattgcat tccgctgtag tgaaaggacg agccatttct gggcacgtgg     3561

cagcagtcgc tgatctccca gctgaggggc tgagcactgg aatgctgtgg ctgcactggc     3621

cccagtccat agaggggtca actatgctgg ctggactggc tgccttgttc ctggcctagg     3681

acttagcttc ataactatca cctgcaccga ctaggctgag gtgctggtac ttgccccaac     3741

ccctactttt gtatttatat gtgtgtgtgt gtgtgcgtgc gtgcgtgcgt gcgtgtatgt     3801

ttggtctgga ccagcttctg ccagcccctg gcctttactt tcttccttgc ctatgcaggg     3861

caaacaaaat gtgaaattct gccctcagct gagctgagta agggctcctg ggggttggct     3921

ggagatgggt gtggcatctg tccaggcctg gaaccgtctc aagacagtgc tggcaaagct     3981

gcagtattga gatgctaagg agctgatgcc acctctttgt cttcccctaa aggagaacat     4041

ggggataaca tgggtgtgtg cccacaacac tctaggtgca gagcccctgt ggcaaagtat     4101

tacagggtgt gggtggggat taccctgaat cggggatttt aatgatggaa gcaggcagag     4161

cctggtgggt gattctgtca acagaaaatt gcaatcatgc aggggctggg agggttagga     4221

tgaaaaaact ggggccattg gaggcccact gtaggtggga gggagctgat tttggggtgg     4281

ggggtgggac tagagggcaa tactgaaggg gttaaacagg tttttgctcc tcaagaattt     4341

gtttgcctgg gcccaggatt ggagggcttc acaccaatac cctgtgtata caagaatcag     4401

atttataata cttccccttt tttgttacgt atgaacacta taaaccaaat tattttgaaa     4461

actggtgcat caccttgtcc ttagcaataa aatgtgttga gcagaggaaa aaaaaaaaaa     4521

aaaaa                                                                 4526


<210>  28
<211>  1064
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Ser Glu Ser Glu Thr Leu Asn Pro Ser Ala Arg Ile Met Thr 
1               5                   10                  15      


Phe Tyr Pro Thr Met Glu Glu Phe Arg Asn Phe Ser Arg Tyr Ile Ala 
            20                  25                  30          


Tyr Ile Glu Ser Gln Gly Ala His Arg Ala Gly Leu Ala Lys Val Val 
        35                  40                  45              


Pro Pro Lys Glu Trp Lys Pro Arg Ala Ser Tyr Asp Asp Ile Asp Asp 
    50                  55                  60                  


Leu Val Ile Pro Ala Pro Ile Gln Gln Leu Val Thr Gly Gln Ser Gly 
65                  70                  75                  80  


Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val Arg Glu 
                85                  90                  95      


Phe Arg Lys Ile Ala Asn Ser Asp Lys Tyr Cys Thr Pro Arg Tyr Ser 
            100                 105                 110         


Glu Phe Glu Glu Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr Phe Asn 
        115                 120                 125             


Pro Pro Ile Tyr Gly Ala Asp Val Asn Gly Thr Leu Tyr Glu Lys His 
    130                 135                 140                 


Val Asp Glu Trp Asn Ile Gly Arg Leu Arg Thr Ile Leu Asp Leu Val 
145                 150                 155                 160 


Glu Lys Glu Ser Gly Ile Thr Ile Glu Gly Val Asn Thr Pro Tyr Leu 
                165                 170                 175     


Tyr Phe Gly Met Trp Lys Thr Ser Phe Ala Trp His Thr Glu Asp Met 
            180                 185                 190         


Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys Ser Trp 
        195                 200                 205             


Tyr Ser Val Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu Ala Lys 
    210                 215                 220                 


Gly Phe Phe Pro Gly Ser Ala Gln Ser Cys Glu Ala Phe Leu Arg His 
225                 230                 235                 240 


Lys Met Thr Leu Ile Ser Pro Leu Met Leu Lys Lys Tyr Gly Ile Pro 
                245                 250                 255     


Phe Asp Lys Val Thr Gln Glu Ala Gly Glu Phe Met Ile Thr Phe Pro 
            260                 265                 270         


Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu Ser 
        275                 280                 285             


Thr Asn Phe Ala Thr Arg Arg Trp Ile Glu Tyr Gly Lys Gln Ala Val 
    290                 295                 300                 


Leu Cys Ser Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp Val Phe 
305                 310                 315                 320 


Val Arg Lys Phe Gln Pro Glu Arg Tyr Lys Leu Trp Lys Ala Gly Lys 
                325                 330                 335     


Asp Asn Thr Val Ile Asp His Thr Leu Pro Thr Pro Glu Ala Ala Glu 
            340                 345                 350         


Phe Leu Lys Glu Ser Glu Leu Pro Pro Arg Ala Gly Asn Glu Glu Glu 
        355                 360                 365             


Cys Pro Glu Glu Asp Met Glu Gly Val Glu Asp Gly Glu Glu Gly Asp 
    370                 375                 380                 


Leu Lys Thr Ser Leu Ala Lys His Arg Ile Gly Thr Lys Arg His Arg 
385                 390                 395                 400 


Val Cys Leu Glu Ile Pro Gln Glu Val Ser Gln Ser Glu Leu Phe Pro 
                405                 410                 415     


Lys Glu Asp Leu Ser Ser Glu Gln Tyr Glu Met Thr Glu Cys Pro Ala 
            420                 425                 430         


Ala Leu Ala Pro Val Arg Pro Thr His Ser Ser Val Arg Gln Val Glu 
        435                 440                 445             


Asp Gly Leu Thr Phe Pro Asp Tyr Ser Asp Ser Thr Glu Val Lys Phe 
    450                 455                 460                 


Glu Glu Leu Lys Asn Val Lys Leu Glu Glu Glu Asp Glu Glu Glu Glu 
465                 470                 475                 480 


Gln Ala Ala Ala Ala Leu Asp Leu Ser Val Asn Pro Ala Ser Val Gly 
                485                 490                 495     


Gly Arg Leu Val Phe Ser Gly Ser Lys Lys Lys Ser Ser Ser Ser Leu 
            500                 505                 510         


Gly Ser Gly Ser Ser Arg Asp Ser Ile Ser Ser Asp Ser Glu Thr Ser 
        515                 520                 525             


Glu Pro Leu Ser Cys Arg Ala Gln Gly Gln Thr Gly Val Leu Thr Val 
    530                 535                 540                 


His Ser Tyr Ala Lys Gly Asp Gly Arg Val Thr Val Gly Glu Pro Cys 
545                 550                 555                 560 


Thr Arg Lys Lys Gly Ser Ala Ala Arg Ser Phe Ser Glu Arg Glu Leu 
                565                 570                 575     


Ala Glu Val Ala Asp Glu Tyr Met Phe Ser Leu Glu Glu Asn Lys Lys 
            580                 585                 590         


Ser Lys Gly Arg Arg Gln Pro Leu Ser Lys Leu Pro Arg His His Pro 
        595                 600                 605             


Leu Val Leu Gln Glu Cys Val Ser Asp Asp Glu Thr Ser Glu Gln Leu 
    610                 615                 620                 


Thr Pro Glu Glu Glu Ala Glu Glu Thr Glu Ala Trp Ala Lys Pro Leu 
625                 630                 635                 640 


Ser Gln Leu Trp Gln Asn Arg Pro Pro Asn Phe Glu Ala Glu Lys Glu 
                645                 650                 655     


Phe Asn Glu Thr Met Ala Gln Gln Ala Pro His Cys Ala Val Cys Met 
            660                 665                 670         


Ile Phe Gln Thr Tyr His Gln Val Glu Phe Gly Gly Phe Asn Gln Asn 
        675                 680                 685             


Cys Gly Asn Ala Ser Asp Leu Ala Pro Gln Lys Gln Arg Thr Lys Pro 
    690                 695                 700                 


Leu Ile Pro Glu Met Cys Phe Thr Ser Thr Gly Cys Ser Thr Asp Ile 
705                 710                 715                 720 


Asn Leu Ser Thr Pro Tyr Leu Glu Glu Asp Gly Thr Ser Ile Leu Val 
                725                 730                 735     


Ser Cys Lys Lys Cys Ser Val Arg Val His Ala Ser Cys Tyr Gly Val 
            740                 745                 750         


Pro Pro Ala Lys Ala Ser Glu Asp Trp Met Cys Ser Arg Cys Ser Ala 
        755                 760                 765             


Asn Ala Leu Glu Glu Asp Cys Cys Leu Cys Ser Leu Arg Gly Gly Ala 
    770                 775                 780                 


Leu Gln Arg Ala Asn Asp Asp Arg Trp Val His Val Ser Cys Ala Val 
785                 790                 795                 800 


Ala Ile Leu Glu Ala Arg Phe Val Asn Ile Ala Glu Arg Ser Pro Val 
                805                 810                 815     


Asp Val Ser Lys Ile Pro Leu Pro Arg Phe Lys Leu Lys Cys Ile Phe 
            820                 825                 830         


Cys Lys Lys Arg Arg Lys Arg Thr Ala Gly Cys Cys Val Gln Cys Ser 
        835                 840                 845             


His Gly Arg Cys Pro Thr Ala Phe His Val Ser Cys Ala Gln Ala Ala 
    850                 855                 860                 


Gly Val Met Met Gln Pro Asp Asp Trp Pro Phe Val Val Phe Ile Thr 
865                 870                 875                 880 


Cys Phe Arg His Lys Ile Pro Asn Leu Glu Arg Ala Lys Gly Ala Leu 
                885                 890                 895     


Gln Ser Ile Thr Ala Gly Gln Lys Val Ile Ser Lys His Lys Asn Gly 
            900                 905                 910         


Arg Phe Tyr Gln Cys Glu Val Val Arg Leu Thr Thr Glu Thr Phe Tyr 
        915                 920                 925             


Glu Val Asn Phe Asp Asp Gly Ser Phe Ser Asp Asn Leu Tyr Pro Glu 
    930                 935                 940                 


Asp Ile Val Ser Gln Asp Cys Leu Gln Phe Gly Pro Pro Ala Glu Gly 
945                 950                 955                 960 


Glu Val Val Gln Val Arg Trp Thr Asp Gly Gln Val Tyr Gly Ala Lys 
                965                 970                 975     


Phe Val Ala Ser His Pro Ile Gln Met Tyr Gln Val Glu Phe Glu Asp 
            980                 985                 990         


Gly Ser Gln Leu Val Val Lys Arg  Asp Asp Val Tyr Thr  Leu Asp Glu 
        995                 1000                 1005             


Glu Leu  Pro Lys Arg Val Lys  Ser Arg Leu Ser Val  Ala Ser Asp 
    1010                 1015                 1020             


Met Arg  Phe Asn Glu Ile Phe  Thr Glu Lys Glu Val  Lys Gln Glu 
    1025                 1030                 1035             


Lys Lys  Arg Gln Arg Val Ile  Asn Ser Arg Tyr Arg  Glu Asp Tyr 
    1040                 1045                 1050             


Ile Glu  Pro Ala Leu Tyr Arg  Ala Ile Met Glu 
    1055                 1060                 


<210>  29
<211>  2318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (249)..(1637)

<400>  29
gagcagatgg gaggtgcggc gacagtgttt gacgagagcc gaaggaggct gtgggaggtg       60

ttggcggcgg cggcgcgggc gcctgaggag gaggaggaga agcggatgag atcgtggggc      120

tcaccagcgt cccccatggc ttctgagtag cgtgggagtg gagtcagcac caagccaggc      180

tccccgcgcc tgccttgccc tcacctgctc ctgctctctg ccagaggcag catggtccgc      240

agggcacc atg ggg ccc gac aga gtg aca gca cga gaa ctg tgc gag aac       290
         Met Gly Pro Asp Arg Val Thr Ala Arg Glu Leu Cys Glu Asn          
         1               5                   10                           

gac gac ctg gcc acc agc ctc gtc ctg gac ccc tac ctc ggt ttc cgc        338
Asp Asp Leu Ala Thr Ser Leu Val Leu Asp Pro Tyr Leu Gly Phe Arg           
15                  20                  25                  30            

acc cat aag atg aac gtc agc cct gtg ccc ccc ctg cgg cga cag cag        386
Thr His Lys Met Asn Val Ser Pro Val Pro Pro Leu Arg Arg Gln Gln           
                35                  40                  45                

cac ctg cgc tca gcg ctg gaa act ttc ctg agg cag cgg gac ctg gag        434
His Leu Arg Ser Ala Leu Glu Thr Phe Leu Arg Gln Arg Asp Leu Glu           
            50                  55                  60                    

gct gcg tac cgg gcc ctg acg ctg gga ggc tgg acg gcc cgc tac ttc        482
Ala Ala Tyr Arg Ala Leu Thr Leu Gly Gly Trp Thr Ala Arg Tyr Phe           
        65                  70                  75                        

cag agc cgg ggc ccg cgg cag gag gct gcc ctc aag acc cac gtc tat        530
Gln Ser Arg Gly Pro Arg Gln Glu Ala Ala Leu Lys Thr His Val Tyr           
    80                  85                  90                            

cgc tac ctc cgt gcc ttc ctg ccg gaa agt ggc ttt acc atc ctg ccc        578
Arg Tyr Leu Arg Ala Phe Leu Pro Glu Ser Gly Phe Thr Ile Leu Pro           
95                  100                 105                 110           

tgc acg cgc tac tcc atg gag acc aac ggg gcc aag atc gtg tcc act        626
Cys Thr Arg Tyr Ser Met Glu Thr Asn Gly Ala Lys Ile Val Ser Thr           
                115                 120                 125               

cgt gct tgg aaa aag aat gag aag ctg gag ctg ctg gtg ggc tgc att        674
Arg Ala Trp Lys Lys Asn Glu Lys Leu Glu Leu Leu Val Gly Cys Ile           
            130                 135                 140                   

gca gag ctg cgg gag gca gat gag ggg ctg ctg agg gcc ggt gag aat        722
Ala Glu Leu Arg Glu Ala Asp Glu Gly Leu Leu Arg Ala Gly Glu Asn           
        145                 150                 155                       

gac ttc agc atc atg tac tca acc cgc aag cgg agt gct cag ctg tgg        770
Asp Phe Ser Ile Met Tyr Ser Thr Arg Lys Arg Ser Ala Gln Leu Trp           
    160                 165                 170                           

ctg ggc cca gcc gcc ttc atc aac cat gac tgc aaa ccc aac tgc aag        818
Leu Gly Pro Ala Ala Phe Ile Asn His Asp Cys Lys Pro Asn Cys Lys           
175                 180                 185                 190           

ttt gtg cct gca gat ggg aac gca gcc tgc gtg aag gtg ctc cgg gac        866
Phe Val Pro Ala Asp Gly Asn Ala Ala Cys Val Lys Val Leu Arg Asp           
                195                 200                 205               

att gag cct ggg gac gag gtg aca tgc ttc tac ggc gag ggc ttc ttc        914
Ile Glu Pro Gly Asp Glu Val Thr Cys Phe Tyr Gly Glu Gly Phe Phe           
            210                 215                 220                   

ggc gag aag aat gag cac tgt gaa tgc cac acc tgt gag agg aaa ggt        962
Gly Glu Lys Asn Glu His Cys Glu Cys His Thr Cys Glu Arg Lys Gly           
        225                 230                 235                       

gaa gga gct ttc cga acc agg cct agg gag ccc gcg ttg cca cca cgg       1010
Glu Gly Ala Phe Arg Thr Arg Pro Arg Glu Pro Ala Leu Pro Pro Arg           
    240                 245                 250                           

ccc ctg gac aag tac cag ctg cgt gag acc aag cgg cgg ctg cag caa       1058
Pro Leu Asp Lys Tyr Gln Leu Arg Glu Thr Lys Arg Arg Leu Gln Gln           
255                 260                 265                 270           

ggc ctg gac agt ggc agc cga cag ggc ctg ctg ggc cct cgg gcc tgc       1106
Gly Leu Asp Ser Gly Ser Arg Gln Gly Leu Leu Gly Pro Arg Ala Cys           
                275                 280                 285               

gtg cac cca tcc ccg ctg cgc cgg gac cca ttc tgc gcc gcc tgc cag       1154
Val His Pro Ser Pro Leu Arg Arg Asp Pro Phe Cys Ala Ala Cys Gln           
            290                 295                 300                   

ccc ctg cgc ctg cca gcc tgc agc gcc cgc cca gac acc tca ccc ctc       1202
Pro Leu Arg Leu Pro Ala Cys Ser Ala Arg Pro Asp Thr Ser Pro Leu           
        305                 310                 315                       

tgg ctc cag tgg ctg cct cag ccc cag ccc cga gtg cgg ccc cgg aag       1250
Trp Leu Gln Trp Leu Pro Gln Pro Gln Pro Arg Val Arg Pro Arg Lys           
    320                 325                 330                           

cgc cga cgc ccc cgg ccc cgg agg gcc cca gtg ctc tcc acc cac cac       1298
Arg Arg Arg Pro Arg Pro Arg Arg Ala Pro Val Leu Ser Thr His His           
335                 340                 345                 350           

gct gcc cgc gtc tcc ctg cac cga tgg gga ggc tgt ggc ccc cac tgc       1346
Ala Ala Arg Val Ser Leu His Arg Trp Gly Gly Cys Gly Pro His Cys           
                355                 360                 365               

cgc ctg cga gga gag gcc ctg gtg gcc ctg ggc cag ccc ccc cac gcc       1394
Arg Leu Arg Gly Glu Ala Leu Val Ala Leu Gly Gln Pro Pro His Ala           
            370                 375                 380                   

cgc tgg gcc cct cag cag gac tgg cac tgg gcc cgg cgc tat ggg ctg       1442
Arg Trp Ala Pro Gln Gln Asp Trp His Trp Ala Arg Arg Tyr Gly Leu           
        385                 390                 395                       

cct tac gtg gtg cgt gtg gac ctt cgt cgc ctg gcc cca gcc cca cca       1490
Pro Tyr Val Val Arg Val Asp Leu Arg Arg Leu Ala Pro Ala Pro Pro           
    400                 405                 410                           

gct acc cca gcc cct gct ggg acc cca ggc ccc atc ctg atc ccg aag       1538
Ala Thr Pro Ala Pro Ala Gly Thr Pro Gly Pro Ile Leu Ile Pro Lys           
415                 420                 425                 430           

cag gcc ctc gcc ttc gcc ccc ttc tcc cca ccc aag cgc cta cgg ctg       1586
Gln Ala Leu Ala Phe Ala Pro Phe Ser Pro Pro Lys Arg Leu Arg Leu           
                435                 440                 445               

gtg gtc agc cac ggc tcc atc gac ctg gat gtc ggc ggt gaa gag ctg       1634
Val Val Ser His Gly Ser Ile Asp Leu Asp Val Gly Gly Glu Glu Leu           
            450                 455                 460                   

tga caggccggac ggggaggccc agcagggaga gagggtctct ctcctagctg            1687

ctacccagga cctccagaag gagcccttgg acctctggga gggagctgac ccttgactcc     1747

agcatagctc tgaccctgga atggggttgg tttggacacc cccagggatc tgagccctga     1807

ccctttgtga ctgctgaccc ctgagccacc cccactccca cagggagccc cggccatttg     1867

ctgccctccc cacccctgcc ccagcctcag gactgcagga gccatccgcc cccctcagcc     1927

ccttcctccc cagggagcaa agccataagg ggcaggggcc accccacggc atctccccag     1987

aagtacaggc ctcaggagga ggtggaactg atgtaggggg tggcactccc cagagactgc     2047

cctcacgagg ggactgggtt cgctctcagc tctgcagctg tctgcggtgg ggggaaggtt     2107

ggggggtgtc tggaggcatg ttcccctcac caccccccgt gggtctcagg gaggccgggt     2167

gtgacctcat ctttctcatg gtgctatcct ggtgctattg gggtggggag ctccctcccc     2227

tcccccacac cagaaagggg tatgttgggg gcttggaagc acttgaactt tttattttat     2287

taaaaccttg ttataagcag caaaaaaaaa a                                    2318


<210>  30
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gly Pro Asp Arg Val Thr Ala Arg Glu Leu Cys Glu Asn Asp Asp 
1               5                   10                  15      


Leu Ala Thr Ser Leu Val Leu Asp Pro Tyr Leu Gly Phe Arg Thr His 
            20                  25                  30          


Lys Met Asn Val Ser Pro Val Pro Pro Leu Arg Arg Gln Gln His Leu 
        35                  40                  45              


Arg Ser Ala Leu Glu Thr Phe Leu Arg Gln Arg Asp Leu Glu Ala Ala 
    50                  55                  60                  


Tyr Arg Ala Leu Thr Leu Gly Gly Trp Thr Ala Arg Tyr Phe Gln Ser 
65                  70                  75                  80  


Arg Gly Pro Arg Gln Glu Ala Ala Leu Lys Thr His Val Tyr Arg Tyr 
                85                  90                  95      


Leu Arg Ala Phe Leu Pro Glu Ser Gly Phe Thr Ile Leu Pro Cys Thr 
            100                 105                 110         


Arg Tyr Ser Met Glu Thr Asn Gly Ala Lys Ile Val Ser Thr Arg Ala 
        115                 120                 125             


Trp Lys Lys Asn Glu Lys Leu Glu Leu Leu Val Gly Cys Ile Ala Glu 
    130                 135                 140                 


Leu Arg Glu Ala Asp Glu Gly Leu Leu Arg Ala Gly Glu Asn Asp Phe 
145                 150                 155                 160 


Ser Ile Met Tyr Ser Thr Arg Lys Arg Ser Ala Gln Leu Trp Leu Gly 
                165                 170                 175     


Pro Ala Ala Phe Ile Asn His Asp Cys Lys Pro Asn Cys Lys Phe Val 
            180                 185                 190         


Pro Ala Asp Gly Asn Ala Ala Cys Val Lys Val Leu Arg Asp Ile Glu 
        195                 200                 205             


Pro Gly Asp Glu Val Thr Cys Phe Tyr Gly Glu Gly Phe Phe Gly Glu 
    210                 215                 220                 


Lys Asn Glu His Cys Glu Cys His Thr Cys Glu Arg Lys Gly Glu Gly 
225                 230                 235                 240 


Ala Phe Arg Thr Arg Pro Arg Glu Pro Ala Leu Pro Pro Arg Pro Leu 
                245                 250                 255     


Asp Lys Tyr Gln Leu Arg Glu Thr Lys Arg Arg Leu Gln Gln Gly Leu 
            260                 265                 270         


Asp Ser Gly Ser Arg Gln Gly Leu Leu Gly Pro Arg Ala Cys Val His 
        275                 280                 285             


Pro Ser Pro Leu Arg Arg Asp Pro Phe Cys Ala Ala Cys Gln Pro Leu 
    290                 295                 300                 


Arg Leu Pro Ala Cys Ser Ala Arg Pro Asp Thr Ser Pro Leu Trp Leu 
305                 310                 315                 320 


Gln Trp Leu Pro Gln Pro Gln Pro Arg Val Arg Pro Arg Lys Arg Arg 
                325                 330                 335     


Arg Pro Arg Pro Arg Arg Ala Pro Val Leu Ser Thr His His Ala Ala 
            340                 345                 350         


Arg Val Ser Leu His Arg Trp Gly Gly Cys Gly Pro His Cys Arg Leu 
        355                 360                 365             


Arg Gly Glu Ala Leu Val Ala Leu Gly Gln Pro Pro His Ala Arg Trp 
    370                 375                 380                 


Ala Pro Gln Gln Asp Trp His Trp Ala Arg Arg Tyr Gly Leu Pro Tyr 
385                 390                 395                 400 


Val Val Arg Val Asp Leu Arg Arg Leu Ala Pro Ala Pro Pro Ala Thr 
                405                 410                 415     


Pro Ala Pro Ala Gly Thr Pro Gly Pro Ile Leu Ile Pro Lys Gln Ala 
            420                 425                 430         


Leu Ala Phe Ala Pro Phe Ser Pro Pro Lys Arg Leu Arg Leu Val Val 
        435                 440                 445             


Ser His Gly Ser Ile Asp Leu Asp Val Gly Gly Glu Glu Leu 
    450                 455                 460         


<210>  31
<211>  3773
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (289)..(2184)

<400>  31
aggcgcacag gtaccatttt gaccgtaaac atcctgccga tttgaaccga ggatttgggc       60

ggcaggaaga gccgcggcgt aacggcagcc atcttgtttg tttgagtgaa tcggaaagga      120

ggcgccggct gtggcggcgg cgggagctgc tcggaagcta cacctcgcaa gggctccccc      180

ctttccccac cccctccccc gacccttttc ccctccccgg gccacccagc ccgcccaact      240

cccagcggag agcaaggttt tcttctgttt tcatagccag ccagaaca atg ttc tac       297
                                                     Met Phe Tyr          
                                                     1                    

gca cat ttt gtt ctc agt aaa aga ggg cct ctg gcc aaa att tgg cta        345
Ala His Phe Val Leu Ser Lys Arg Gly Pro Leu Ala Lys Ile Trp Leu           
    5                   10                  15                            

gcg gcc cat tgg gat aag aag cta acc aaa gcc cat gtg ttc gag tgt        393
Ala Ala His Trp Asp Lys Lys Leu Thr Lys Ala His Val Phe Glu Cys           
20                  25                  30                  35            

aat tta gag agc agc gtg gag agt atc atc tca cca aag gtg aaa atg        441
Asn Leu Glu Ser Ser Val Glu Ser Ile Ile Ser Pro Lys Val Lys Met           
                40                  45                  50                

gca tta cgg aca tca gga cat ctc tta ctg gga gta gtt cga atc tat        489
Ala Leu Arg Thr Ser Gly His Leu Leu Leu Gly Val Val Arg Ile Tyr           
            55                  60                  65                    

cac agg aaa gcc aaa tac ctt ctt gca gac tgt aat gaa gca ttc att        537
His Arg Lys Ala Lys Tyr Leu Leu Ala Asp Cys Asn Glu Ala Phe Ile           
        70                  75                  80                        

aag ata aag atg gct ttt cgg cca ggt gtg gtt gac ctg cct gag gaa        585
Lys Ile Lys Met Ala Phe Arg Pro Gly Val Val Asp Leu Pro Glu Glu           
    85                  90                  95                            

aat cgg gaa gca gct tat aat gcc att act tta cct gaa gaa ttt cat        633
Asn Arg Glu Ala Ala Tyr Asn Ala Ile Thr Leu Pro Glu Glu Phe His           
100                 105                 110                 115           

gac ttt gat cag cca ctg cct gac tta gat gac atc gat gtg gcc cag        681
Asp Phe Asp Gln Pro Leu Pro Asp Leu Asp Asp Ile Asp Val Ala Gln           
                120                 125                 130               

cag ttc agc ttg aat cag agt aga gtg gaa gag ata acc atg aga gaa        729
Gln Phe Ser Leu Asn Gln Ser Arg Val Glu Glu Ile Thr Met Arg Glu           
            135                 140                 145                   

gaa gtt ggg aac atc agt att tta caa gaa aat gat ttt ggt gat ttt        777
Glu Val Gly Asn Ile Ser Ile Leu Gln Glu Asn Asp Phe Gly Asp Phe           
        150                 155                 160                       

gga atg gat gat cgt gag ata atg aga gaa ggc agt gct ttt gag gat        825
Gly Met Asp Asp Arg Glu Ile Met Arg Glu Gly Ser Ala Phe Glu Asp           
    165                 170                 175                           

gac gac atg tta gta agc act act act tct aac ctc cta tta gag tct        873
Asp Asp Met Leu Val Ser Thr Thr Thr Ser Asn Leu Leu Leu Glu Ser           
180                 185                 190                 195           

gaa cag agc acc agc aat ctg aat gag aaa att aac cat tta gaa tat        921
Glu Gln Ser Thr Ser Asn Leu Asn Glu Lys Ile Asn His Leu Glu Tyr           
                200                 205                 210               

gaa gat caa tat aag gat gat aat ttt gga gaa gga aat gat ggt gga        969
Glu Asp Gln Tyr Lys Asp Asp Asn Phe Gly Glu Gly Asn Asp Gly Gly           
            215                 220                 225                   

ata tta gat gac aaa ctt att agt aat aat gat ggc ggt atc ttt gat       1017
Ile Leu Asp Asp Lys Leu Ile Ser Asn Asn Asp Gly Gly Ile Phe Asp           
        230                 235                 240                       

gat ccc cct gcc ctc tct gag gca ggg gtg atg ttg cca gag cag cct       1065
Asp Pro Pro Ala Leu Ser Glu Ala Gly Val Met Leu Pro Glu Gln Pro           
    245                 250                 255                           

gca cat gac gat atg gat gag gat gat aat gta tca atg ggt ggg cct       1113
Ala His Asp Asp Met Asp Glu Asp Asp Asn Val Ser Met Gly Gly Pro           
260                 265                 270                 275           

gat agt cct gat tca gtg gat ccc gtt gaa cca atg cca acc atg act       1161
Asp Ser Pro Asp Ser Val Asp Pro Val Glu Pro Met Pro Thr Met Thr           
                280                 285                 290               

gat caa aca aca ctt gtt cca aat gag gaa gaa gca ttt gca ttg gag       1209
Asp Gln Thr Thr Leu Val Pro Asn Glu Glu Glu Ala Phe Ala Leu Glu           
            295                 300                 305                   

cct att gat ata act gtt aaa gaa aca aaa gcc aag agg aag agg aag       1257
Pro Ile Asp Ile Thr Val Lys Glu Thr Lys Ala Lys Arg Lys Arg Lys           
        310                 315                 320                       

cta att gtt gac agt gtc aaa gag ttg gat agc aag aca att aga gcc       1305
Leu Ile Val Asp Ser Val Lys Glu Leu Asp Ser Lys Thr Ile Arg Ala           
    325                 330                 335                           

caa ctt agt gat tat tca gat att gtt act act ttg gat ctg gca ccg       1353
Gln Leu Ser Asp Tyr Ser Asp Ile Val Thr Thr Leu Asp Leu Ala Pro           
340                 345                 350                 355           

ccc acc aag aaa ttg atg atg tgg aaa gag aca gga gga gta gaa aaa       1401
Pro Thr Lys Lys Leu Met Met Trp Lys Glu Thr Gly Gly Val Glu Lys           
                360                 365                 370               

ctg ttt tct tta cct gct cag cct ttg tgg aat aac aga cta ctg aag       1449
Leu Phe Ser Leu Pro Ala Gln Pro Leu Trp Asn Asn Arg Leu Leu Lys           
            375                 380                 385                   

ctc ttt aca cgc tgt ctt aca ccg ctt gta cca gaa gac ctt aga aaa       1497
Leu Phe Thr Arg Cys Leu Thr Pro Leu Val Pro Glu Asp Leu Arg Lys           
        390                 395                 400                       

agg agg aaa gga gga gag gca gat aat ttg gat gaa ttc ctc aaa gaa       1545
Arg Arg Lys Gly Gly Glu Ala Asp Asn Leu Asp Glu Phe Leu Lys Glu           
    405                 410                 415                           

ttt gaa aat cca gag gtt cct aga gag gac cag caa cag cag cat cag       1593
Phe Glu Asn Pro Glu Val Pro Arg Glu Asp Gln Gln Gln Gln His Gln           
420                 425                 430                 435           

cag cgt gat gtt atc gat gag ccc att att gaa gag cca agc cgc ctc       1641
Gln Arg Asp Val Ile Asp Glu Pro Ile Ile Glu Glu Pro Ser Arg Leu           
                440                 445                 450               

cag gag tca gtg atg gag gcc agc aga aca aac ata gat gag tca gct       1689
Gln Glu Ser Val Met Glu Ala Ser Arg Thr Asn Ile Asp Glu Ser Ala           
            455                 460                 465                   

atg cct cca cca cca cct cag gga gtt aag cga aaa gct gga caa att       1737
Met Pro Pro Pro Pro Pro Gln Gly Val Lys Arg Lys Ala Gly Gln Ile           
        470                 475                 480                       

gac cca gag cct gtg atg cct cct cag cag gta gag cag atg gaa ata       1785
Asp Pro Glu Pro Val Met Pro Pro Gln Gln Val Glu Gln Met Glu Ile           
    485                 490                 495                           

cca cct gta gag ctt ccc cca gaa gaa cct cca aat atc tgt cag cta       1833
Pro Pro Val Glu Leu Pro Pro Glu Glu Pro Pro Asn Ile Cys Gln Leu           
500                 505                 510                 515           

ata cca gag tta gaa ctt ctg cca gaa aaa gag aag gag aaa gag aag       1881
Ile Pro Glu Leu Glu Leu Leu Pro Glu Lys Glu Lys Glu Lys Glu Lys           
                520                 525                 530               

gaa aaa gaa gat gat gaa gag gaa gag gat gaa gat gca tca ggg ggc       1929
Glu Lys Glu Asp Asp Glu Glu Glu Glu Asp Glu Asp Ala Ser Gly Gly           
            535                 540                 545                   

gat caa gat cag gaa gaa aga aga tgg aac aaa agg act cag cag atg       1977
Asp Gln Asp Gln Glu Glu Arg Arg Trp Asn Lys Arg Thr Gln Gln Met           
        550                 555                 560                       

ctt cat ggt ctt cag cgt gct ctt gct aaa act gga gct gaa tct atc       2025
Leu His Gly Leu Gln Arg Ala Leu Ala Lys Thr Gly Ala Glu Ser Ile           
    565                 570                 575                           

agt ttg ctt gag tta tgt cga aat acg aac aga aaa caa gct gcc gca       2073
Ser Leu Leu Glu Leu Cys Arg Asn Thr Asn Arg Lys Gln Ala Ala Ala           
580                 585                 590                 595           

aag ttc tac agc ttc ttg gtt ctt aaa aag cag caa gct att gag ctg       2121
Lys Phe Tyr Ser Phe Leu Val Leu Lys Lys Gln Gln Ala Ile Glu Leu           
                600                 605                 610               

aca cag gaa gaa ccg tac agt gac atc atc gca aca cct gga cca agg       2169
Thr Gln Glu Glu Pro Tyr Ser Asp Ile Ile Ala Thr Pro Gly Pro Arg           
            615                 620                 625                   

ttc cat att ata taa ggagctagaa gcattatagc tagtgtttga ttcactagtg       2224
Phe His Ile Ile                                                           
        630                                                               

cttacaaatt gcccccatgt gtaggggaca cagaaccctt tgagaaaact tagatttttg     2284

tctgtacaaa gtctttgcct ttttccttct tcattttttt ccagtacatt aaatttgtca     2344

atttcatctt tgagggaaac tgattagatg ggttgtgttt gtgttctgat ggagaaaaca     2404

gcaccccaag gactcagaag atgattttaa cagttcagaa cagatgtgtg caatattggt     2464

gcatgtaata atgttgagtg gcagtcaaaa gtcatgattt ttatcttagt tcttcattac     2524

tgcattgaaa aggaaaacct gtctgagaaa atgcctgaca gtttaattta aaactatggt     2584

gtaagtcttt gacaagaaaa aaaaacaaac aaacacttct ttccatcagt aacactggca     2644

atcttcctgt taaccactct ccttagggat ggtatctgaa acaacaatgg tcaccctctt     2704

gagattcgtt ttaagtgtaa ttccataatg agcagaggtg tacgcgaaat tgtgttatga     2764

ctgatagcct tcagctacaa aaagatagga ctgacctggt ttaaagtgtt ctattttgta     2824

aatcattcca tttgagtctt tctgatgaac ttggctatac tgaaatctgt tattttagtg     2884

aggctccaaa atgagcaaag ctaggcctga ttagagtaga gtgactatta aaaaacataa     2944

ctttctagga gctataaatc aaagttttaa aaagatgttt ggatatattt gagtattccg     3004

atcatgaaaa cagaaattgc cctgcctact acaaggacag actgatggga aattatgcac     3064

ctggtcaact tagcttttaa gcagacgatg ctgtaaaaac taacggcttc tctgatattt     3124

attgtaagtt ttagtactga tctccttttc cagtgctgca cactcctggt ttggaacttt     3184

aatagcgttg caacgaaatc ctatatccag tttcctgtaa tttaattgaa gaaaaataca     3244

tccaaataaa gactttatta ttaacagacc agatagcatc agaaatcatg tgactgttat     3304

gattatcaga atgtcttaac tttttagggc aaagttaaca ctgaaagttc tagcttaagt     3364

gttgaaactt ttgtgggaaa aaaaaatcac ttttgaaact cagacttcag tgtataccca     3424

ataatttaaa attatgtgaa atgttttaaa tttgtgaact cgtaattact gttttaatga     3484

ttcagtttct tcagagtggt aattgtataa aattgctatt gcagctttac attcaatatg     3544

atgtgcctgt aaaccaagga gttttccccg tttgtaaaaa gacattgtag ataattgaat     3604

gtttgatttt agaaaggtca ttagtttctt gttacacatt ttgttagtct ggtttttgtt     3664

gcttatcggg tttaatattg ttcttgaaaa tagttgatgc tatgttatgt ataacttttc     3724

taataaaagt tgtgttataa gctgtaaaaa aaaaaaaaaa aaaaaaaaa                 3773


<210>  32
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Phe Tyr Ala His Phe Val Leu Ser Lys Arg Gly Pro Leu Ala Lys 
1               5                   10                  15      


Ile Trp Leu Ala Ala His Trp Asp Lys Lys Leu Thr Lys Ala His Val 
            20                  25                  30          


Phe Glu Cys Asn Leu Glu Ser Ser Val Glu Ser Ile Ile Ser Pro Lys 
        35                  40                  45              


Val Lys Met Ala Leu Arg Thr Ser Gly His Leu Leu Leu Gly Val Val 
    50                  55                  60                  


Arg Ile Tyr His Arg Lys Ala Lys Tyr Leu Leu Ala Asp Cys Asn Glu 
65                  70                  75                  80  


Ala Phe Ile Lys Ile Lys Met Ala Phe Arg Pro Gly Val Val Asp Leu 
                85                  90                  95      


Pro Glu Glu Asn Arg Glu Ala Ala Tyr Asn Ala Ile Thr Leu Pro Glu 
            100                 105                 110         


Glu Phe His Asp Phe Asp Gln Pro Leu Pro Asp Leu Asp Asp Ile Asp 
        115                 120                 125             


Val Ala Gln Gln Phe Ser Leu Asn Gln Ser Arg Val Glu Glu Ile Thr 
    130                 135                 140                 


Met Arg Glu Glu Val Gly Asn Ile Ser Ile Leu Gln Glu Asn Asp Phe 
145                 150                 155                 160 


Gly Asp Phe Gly Met Asp Asp Arg Glu Ile Met Arg Glu Gly Ser Ala 
                165                 170                 175     


Phe Glu Asp Asp Asp Met Leu Val Ser Thr Thr Thr Ser Asn Leu Leu 
            180                 185                 190         


Leu Glu Ser Glu Gln Ser Thr Ser Asn Leu Asn Glu Lys Ile Asn His 
        195                 200                 205             


Leu Glu Tyr Glu Asp Gln Tyr Lys Asp Asp Asn Phe Gly Glu Gly Asn 
    210                 215                 220                 


Asp Gly Gly Ile Leu Asp Asp Lys Leu Ile Ser Asn Asn Asp Gly Gly 
225                 230                 235                 240 


Ile Phe Asp Asp Pro Pro Ala Leu Ser Glu Ala Gly Val Met Leu Pro 
                245                 250                 255     


Glu Gln Pro Ala His Asp Asp Met Asp Glu Asp Asp Asn Val Ser Met 
            260                 265                 270         


Gly Gly Pro Asp Ser Pro Asp Ser Val Asp Pro Val Glu Pro Met Pro 
        275                 280                 285             


Thr Met Thr Asp Gln Thr Thr Leu Val Pro Asn Glu Glu Glu Ala Phe 
    290                 295                 300                 


Ala Leu Glu Pro Ile Asp Ile Thr Val Lys Glu Thr Lys Ala Lys Arg 
305                 310                 315                 320 


Lys Arg Lys Leu Ile Val Asp Ser Val Lys Glu Leu Asp Ser Lys Thr 
                325                 330                 335     


Ile Arg Ala Gln Leu Ser Asp Tyr Ser Asp Ile Val Thr Thr Leu Asp 
            340                 345                 350         


Leu Ala Pro Pro Thr Lys Lys Leu Met Met Trp Lys Glu Thr Gly Gly 
        355                 360                 365             


Val Glu Lys Leu Phe Ser Leu Pro Ala Gln Pro Leu Trp Asn Asn Arg 
    370                 375                 380                 


Leu Leu Lys Leu Phe Thr Arg Cys Leu Thr Pro Leu Val Pro Glu Asp 
385                 390                 395                 400 


Leu Arg Lys Arg Arg Lys Gly Gly Glu Ala Asp Asn Leu Asp Glu Phe 
                405                 410                 415     


Leu Lys Glu Phe Glu Asn Pro Glu Val Pro Arg Glu Asp Gln Gln Gln 
            420                 425                 430         


Gln His Gln Gln Arg Asp Val Ile Asp Glu Pro Ile Ile Glu Glu Pro 
        435                 440                 445             


Ser Arg Leu Gln Glu Ser Val Met Glu Ala Ser Arg Thr Asn Ile Asp 
    450                 455                 460                 


Glu Ser Ala Met Pro Pro Pro Pro Pro Gln Gly Val Lys Arg Lys Ala 
465                 470                 475                 480 


Gly Gln Ile Asp Pro Glu Pro Val Met Pro Pro Gln Gln Val Glu Gln 
                485                 490                 495     


Met Glu Ile Pro Pro Val Glu Leu Pro Pro Glu Glu Pro Pro Asn Ile 
            500                 505                 510         


Cys Gln Leu Ile Pro Glu Leu Glu Leu Leu Pro Glu Lys Glu Lys Glu 
        515                 520                 525             


Lys Glu Lys Glu Lys Glu Asp Asp Glu Glu Glu Glu Asp Glu Asp Ala 
    530                 535                 540                 


Ser Gly Gly Asp Gln Asp Gln Glu Glu Arg Arg Trp Asn Lys Arg Thr 
545                 550                 555                 560 


Gln Gln Met Leu His Gly Leu Gln Arg Ala Leu Ala Lys Thr Gly Ala 
                565                 570                 575     


Glu Ser Ile Ser Leu Leu Glu Leu Cys Arg Asn Thr Asn Arg Lys Gln 
            580                 585                 590         


Ala Ala Ala Lys Phe Tyr Ser Phe Leu Val Leu Lys Lys Gln Gln Ala 
        595                 600                 605             


Ile Glu Leu Thr Gln Glu Glu Pro Tyr Ser Asp Ile Ile Ala Thr Pro 
    610                 615                 620                 


Gly Pro Arg Phe His Ile Ile 
625                 630     


<210>  33
<211>  7393
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (865)..(4353)

<400>  33
gagtctgacg ggttcaaaat ggcggcggct gcttcagcgg ctcctcctgt gtgagggaaa       60

caacacccct ccccggcagc ggcggcggcg gcggcggctc tcggagcacc ttcccagcgg      120

ctgggcccgt ggccgctctg tctttcctgg gcaggggacg ctccgggagg aggggcaacg      180

ccagggggcc catcccccgg aatccctctt ctgcgactgg ggagtagccg gggggctcgt      240

cccgcagcgc ggagccagac ctgaggggga gacgcgaggg gagccagggc ccccatcccg      300

gcgcgccgcg ccgctcccgc cctgtccgcc ccccggggcc ggggcccgcg ttccgggggg      360

ccggggcggc gcggggagcc tcgggccggc cggtctcagc tgatcggccg ctgctcccgc      420

aggcgaccag cccctgctgg ccgagggcac ggcgaggagg gcgctccctg cggccggggc      480

cggcccgggg ctcgggcccg ggctgctgac cgctggcctg ggggaggcgg gggcgccccg      540

ggctcggcgc cgaggggtcg cgctcctctc tcctgacgcc tccgactccc ggtctccaaa      600

gccagaagag aaggtttgat tcagcaactg tttgctccct tttcctggtc gctctgaccc      660

tctctggata ctgggttgat ccacggaaaa accgaagacg acgtttggga tttaattatt      720

cctctcagct ttggaatctt ttacttctca cttggacaag aactcaagag cagaatctcc      780

gtgttgcaat ctggttccta aggaggaaga ggaaggcagc cctggagtgg tttctttaca      840

gtaatttcaa cagaagagtg agag atg gaa ccc gaa gaa gaa agg att cgt         891
                           Met Glu Pro Glu Glu Glu Arg Ile Arg            
                           1               5                              

tac agc cag aga ttg cgt ggt acc atg cga cga cgc tat gaa gat gat        939
Tyr Ser Gln Arg Leu Arg Gly Thr Met Arg Arg Arg Tyr Glu Asp Asp           
10                  15                  20                  25            

ggc att tca gat gat gaa att gaa gga aaa aga act ttt gac ttg gaa        987
Gly Ile Ser Asp Asp Glu Ile Glu Gly Lys Arg Thr Phe Asp Leu Glu           
                30                  35                  40                

gag aaa ctg cac acc aac aaa tat aat gcc aat ttt gtt act ttt atg       1035
Glu Lys Leu His Thr Asn Lys Tyr Asn Ala Asn Phe Val Thr Phe Met           
            45                  50                  55                    

gaa gga aaa gat ttt aat gta gag tat att cag cgg ggt ggc ttg aga       1083
Glu Gly Lys Asp Phe Asn Val Glu Tyr Ile Gln Arg Gly Gly Leu Arg           
        60                  65                  70                        

gat cct ctg att ttc aag aat tct gat gga ctc gga ata aaa atg ccg       1131
Asp Pro Leu Ile Phe Lys Asn Ser Asp Gly Leu Gly Ile Lys Met Pro           
    75                  80                  85                            

gat cca gac ttc act gtg aat gat gtc aaa atg tgt gtg ggg agt cgt       1179
Asp Pro Asp Phe Thr Val Asn Asp Val Lys Met Cys Val Gly Ser Arg           
90                  95                  100                 105           

cgc atg gtg gat gtc atg gac gtg aac aca cag aaa ggc att gaa atg       1227
Arg Met Val Asp Val Met Asp Val Asn Thr Gln Lys Gly Ile Glu Met           
                110                 115                 120               

acc atg gct cag tgg aca cgc tac tat gag acc cca gag gag gag cga       1275
Thr Met Ala Gln Trp Thr Arg Tyr Tyr Glu Thr Pro Glu Glu Glu Arg           
            125                 130                 135                   

gag aaa ctc tat aat gtc atc agc ctc gag ttt agc cac acc agg ctg       1323
Glu Lys Leu Tyr Asn Val Ile Ser Leu Glu Phe Ser His Thr Arg Leu           
        140                 145                 150                       

gag aat atg gtg cag agg ccc tcc acg gtg gat ttc att gac tgg gta       1371
Glu Asn Met Val Gln Arg Pro Ser Thr Val Asp Phe Ile Asp Trp Val           
    155                 160                 165                           

gac aac atg tgg cca agg cac ttg aag gaa agc cag act gaa tca aca       1419
Asp Asn Met Trp Pro Arg His Leu Lys Glu Ser Gln Thr Glu Ser Thr           
170                 175                 180                 185           

aat gcc atc ttg gag atg cag tac cct aaa gtg cag aag tac tgt cta       1467
Asn Ala Ile Leu Glu Met Gln Tyr Pro Lys Val Gln Lys Tyr Cys Leu           
                190                 195                 200               

atg agt gtt cga ggc tgc tat act gac ttc cat gtg gac ttt ggt ggt       1515
Met Ser Val Arg Gly Cys Tyr Thr Asp Phe His Val Asp Phe Gly Gly           
            205                 210                 215                   

acc tct gtt tgg tat cac atc cat caa ggg gga aag gtc ttc tgg ctc       1563
Thr Ser Val Trp Tyr His Ile His Gln Gly Gly Lys Val Phe Trp Leu           
        220                 225                 230                       

atc ccc cct aca gcc cac aac ctg gag ctg tac gag aat tgg ctg ctg       1611
Ile Pro Pro Thr Ala His Asn Leu Glu Leu Tyr Glu Asn Trp Leu Leu           
    235                 240                 245                           

tca ggg aaa cag gga gac atc ttt ctg ggt gac cgg gta tca gat tgt       1659
Ser Gly Lys Gln Gly Asp Ile Phe Leu Gly Asp Arg Val Ser Asp Cys           
250                 255                 260                 265           

cag cgc att gag ctc aag cag ggc tat acc ttc gtc att ccc tca ggc       1707
Gln Arg Ile Glu Leu Lys Gln Gly Tyr Thr Phe Val Ile Pro Ser Gly           
                270                 275                 280               

tgg att cat gct gtg tat act cct aca gac aca tta gtg ttt ggg ggc       1755
Trp Ile His Ala Val Tyr Thr Pro Thr Asp Thr Leu Val Phe Gly Gly           
            285                 290                 295                   

aat ttt ttg cat agc ttc aac atc cct atg cag tta aaa ata tac aac       1803
Asn Phe Leu His Ser Phe Asn Ile Pro Met Gln Leu Lys Ile Tyr Asn           
        300                 305                 310                       

att gaa gat cgg aca cgg gtt cca aat aag ttt cgc tat cca ttc tac       1851
Ile Glu Asp Arg Thr Arg Val Pro Asn Lys Phe Arg Tyr Pro Phe Tyr           
    315                 320                 325                           

tat gag atg tgt tgg tat gtg ttg gag cgc tat gtg tac tgc ata acc       1899
Tyr Glu Met Cys Trp Tyr Val Leu Glu Arg Tyr Val Tyr Cys Ile Thr           
330                 335                 340                 345           

aac cgt tcc cac cta act aag gaa ttt cag aaa gag tcc ctc agc atg       1947
Asn Arg Ser His Leu Thr Lys Glu Phe Gln Lys Glu Ser Leu Ser Met           
                350                 355                 360               

gat ttg gag tta aat ggg ttg gag tct ggg aat ggg gat gag gaa gca       1995
Asp Leu Glu Leu Asn Gly Leu Glu Ser Gly Asn Gly Asp Glu Glu Ala           
            365                 370                 375                   

gtg gat cga gaa ccc cga cgc ttg agc agc agg cgt tct gtc ctc act       2043
Val Asp Arg Glu Pro Arg Arg Leu Ser Ser Arg Arg Ser Val Leu Thr           
        380                 385                 390                       

agc cct gta gcg aat gga gtc aac ctg gat tat gat gga ctg ggc aaa       2091
Ser Pro Val Ala Asn Gly Val Asn Leu Asp Tyr Asp Gly Leu Gly Lys           
    395                 400                 405                           

acc tgc cga agt ctt cca agt ctg aag aaa act ttg gct ggg gac tca       2139
Thr Cys Arg Ser Leu Pro Ser Leu Lys Lys Thr Leu Ala Gly Asp Ser           
410                 415                 420                 425           

tct tct gac tgt agc cgg ggc tcc cac aat gga caa gtg tgg gat ccc       2187
Ser Ser Asp Cys Ser Arg Gly Ser His Asn Gly Gln Val Trp Asp Pro           
                430                 435                 440               

cag tgt gct ccc cga aag gac agg caa gtg cat ctg acc cat ttt gag       2235
Gln Cys Ala Pro Arg Lys Asp Arg Gln Val His Leu Thr His Phe Glu           
            445                 450                 455                   

ctt gaa ggc ctt cgc tgc ctt gta gat aag ttg gag tct ctg cca ctg       2283
Leu Glu Gly Leu Arg Cys Leu Val Asp Lys Leu Glu Ser Leu Pro Leu           
        460                 465                 470                       

cac aag aaa tgt gtc ccc aca ggg ata gaa gat gaa gat gct ctc att       2331
His Lys Lys Cys Val Pro Thr Gly Ile Glu Asp Glu Asp Ala Leu Ile           
    475                 480                 485                           

gct gat gta aag att ttg ctg gag gag ctt gcc aac agc gat ccc aag       2379
Ala Asp Val Lys Ile Leu Leu Glu Glu Leu Ala Asn Ser Asp Pro Lys           
490                 495                 500                 505           

tta gcc ctc act gga gtt cct ata gta cag tgg cca aaa agg gat aag       2427
Leu Ala Leu Thr Gly Val Pro Ile Val Gln Trp Pro Lys Arg Asp Lys           
                510                 515                 520               

ctt aaa ttc ccc act cgg cca aag gtg cgg gtt cct acc atc ccc att       2475
Leu Lys Phe Pro Thr Arg Pro Lys Val Arg Val Pro Thr Ile Pro Ile           
            525                 530                 535                   

acg aag cct cac act atg aaa cca gct cca cgg tta aca cct gtg agg       2523
Thr Lys Pro His Thr Met Lys Pro Ala Pro Arg Leu Thr Pro Val Arg           
        540                 545                 550                       

cca gct gct gcc tcc ccg att gtg tca gga gcc aga cgg aga cga gtg       2571
Pro Ala Ala Ala Ser Pro Ile Val Ser Gly Ala Arg Arg Arg Arg Val           
    555                 560                 565                           

cga tgt cga aaa tgc aaa gcc tgt gtg caa gga gag tgt ggt gtt tgc       2619
Arg Cys Arg Lys Cys Lys Ala Cys Val Gln Gly Glu Cys Gly Val Cys           
570                 575                 580                 585           

cac tac tgc aga gac atg aag aag ttt ggg ggg cct gga cgc atg aag       2667
His Tyr Cys Arg Asp Met Lys Lys Phe Gly Gly Pro Gly Arg Met Lys           
                590                 595                 600               

cag tcc tgt gtc ctc cga cag tgc ttg gca ccc aga ctg cct cac tca       2715
Gln Ser Cys Val Leu Arg Gln Cys Leu Ala Pro Arg Leu Pro His Ser           
            605                 610                 615                   

gtc aca tgt tcc ctc tgt gga gag gtg gat cag aat gaa gag aca caa       2763
Val Thr Cys Ser Leu Cys Gly Glu Val Asp Gln Asn Glu Glu Thr Gln           
        620                 625                 630                       

gac ttt gag aag aaa ctc atg gaa tgc tgt atc tgc aat gag att gtt       2811
Asp Phe Glu Lys Lys Leu Met Glu Cys Cys Ile Cys Asn Glu Ile Val           
    635                 640                 645                           

cat cct ggc tgc ctc cag atg gac gga gag ggg ttg ctt aac gaa gaa       2859
His Pro Gly Cys Leu Gln Met Asp Gly Glu Gly Leu Leu Asn Glu Glu           
650                 655                 660                 665           

ttg cca aat tgc tgg gaa tgt cca aag tgc tac cag gag gac agc tcg       2907
Leu Pro Asn Cys Trp Glu Cys Pro Lys Cys Tyr Gln Glu Asp Ser Ser           
                670                 675                 680               

gag aaa gcc cag aag cgg aaa atg gaa gag agt gac gaa gaa gct gtg       2955
Glu Lys Ala Gln Lys Arg Lys Met Glu Glu Ser Asp Glu Glu Ala Val           
            685                 690                 695                   

caa gcc aaa gtc ctg cgg ccc ctg cgg agc tgc gat gag cct ctc acg       3003
Gln Ala Lys Val Leu Arg Pro Leu Arg Ser Cys Asp Glu Pro Leu Thr           
        700                 705                 710                       

ccc ccg cct cat tca ccc act tcc atg ctg cag ctc atc cat gac ccg       3051
Pro Pro Pro His Ser Pro Thr Ser Met Leu Gln Leu Ile His Asp Pro           
    715                 720                 725                           

gtt tcc ccc cgg ggt atg gtg act cgg tca tcc cct ggg gct ggc ccc       3099
Val Ser Pro Arg Gly Met Val Thr Arg Ser Ser Pro Gly Ala Gly Pro           
730                 735                 740                 745           

agc gac cac cac agt gcc agc cgc gat gag cgc ttc aaa cgg cgg cag       3147
Ser Asp His His Ser Ala Ser Arg Asp Glu Arg Phe Lys Arg Arg Gln           
                750                 755                 760               

ttg ctg cgg ctg cag gcc aca gag cgc acc atg gta cgg gaa aag gag       3195
Leu Leu Arg Leu Gln Ala Thr Glu Arg Thr Met Val Arg Glu Lys Glu           
            765                 770                 775                   

aac aat ccc agc ggc aaa aag gag ctg tct gaa gtt gag aaa gcc aag       3243
Asn Asn Pro Ser Gly Lys Lys Glu Leu Ser Glu Val Glu Lys Ala Lys           
        780                 785                 790                       

atc cgg gga tcg tac ctc act gtc acg cta cag agg ccc acc aaa gag       3291
Ile Arg Gly Ser Tyr Leu Thr Val Thr Leu Gln Arg Pro Thr Lys Glu           
    795                 800                 805                           

ctc cac ggg aca tcc att gtg ccc aag ctg cag gcc atc acg gcc tcc       3339
Leu His Gly Thr Ser Ile Val Pro Lys Leu Gln Ala Ile Thr Ala Ser           
810                 815                 820                 825           

tct gcc aac ctt cgc cat tcc ccc cgt gtg cta gtg cag cac tgc cca       3387
Ser Ala Asn Leu Arg His Ser Pro Arg Val Leu Val Gln His Cys Pro           
                830                 835                 840               

gcc cga acc ccc cag cgt ggg gat gag gag ggg ctg ggg gga gag gag       3435
Ala Arg Thr Pro Gln Arg Gly Asp Glu Glu Gly Leu Gly Gly Glu Glu           
            845                 850                 855                   

gag gaa gag gag gag gag gag gag gaa gat gac agt gca gag gag ggg       3483
Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Ser Ala Glu Glu Gly           
        860                 865                 870                       

ggt gca gcc agg ctg aat ggc cgg ggc agt tgg gct cag gat gga gac       3531
Gly Ala Ala Arg Leu Asn Gly Arg Gly Ser Trp Ala Gln Asp Gly Asp           
    875                 880                 885                           

gaa agc tgg atg cag cgg gag gtc tgg atg tct gtc ttc cgc tac ctc       3579
Glu Ser Trp Met Gln Arg Glu Val Trp Met Ser Val Phe Arg Tyr Leu           
890                 895                 900                 905           

agc cgc aga gaa ctt tgt gaa tgt atg cga gtg tgc aag acg tgg tat       3627
Ser Arg Arg Glu Leu Cys Glu Cys Met Arg Val Cys Lys Thr Trp Tyr           
                910                 915                 920               

aaa tgg tgc tgc gac aag aga ctt tgg aca aaa att gac ttg agt agg       3675
Lys Trp Cys Cys Asp Lys Arg Leu Trp Thr Lys Ile Asp Leu Ser Arg           
            925                 930                 935                   

tgt aag gcc att gtg ccc cag gcc ctc agt ggc atc atc aag agg cag       3723
Cys Lys Ala Ile Val Pro Gln Ala Leu Ser Gly Ile Ile Lys Arg Gln           
        940                 945                 950                       

cca gtc agc ctt gac ctc agt tgg acc aac atc tct aaa aag caa ctg       3771
Pro Val Ser Leu Asp Leu Ser Trp Thr Asn Ile Ser Lys Lys Gln Leu           
    955                 960                 965                           

aca tgg ctc gtc aat agg ctg cca gga ctg aaa gac ctc ctc cta gca       3819
Thr Trp Leu Val Asn Arg Leu Pro Gly Leu Lys Asp Leu Leu Leu Ala           
970                 975                 980                 985           

ggc tgc tcc tgg tct gca gtc tct gcc ctc agc acc tcc agc tgc  ccc      3867
Gly Cys Ser Trp Ser Ala Val Ser Ala Leu Ser Thr Ser Ser Cys  Pro          
                990                 995                 1000              

ctt ctc agg acc  ctt gat ctt cgg tgg  gca gta gga atc aag  gac        3912
Leu Leu Arg Thr  Leu Asp Leu Arg Trp  Ala Val Gly Ile Lys  Asp            
            1005                 1010                 1015                

cct caa att cgg  gac ttg ctt act cca  ccg gct gat aaa cca  ggt        3957
Pro Gln Ile Arg  Asp Leu Leu Thr Pro  Pro Ala Asp Lys Pro  Gly            
            1020                 1025                 1030                

cag gac aat cgc  agc aag ctc cgg aac  atg acc gac ttc cgg  ctg        4002
Gln Asp Asn Arg  Ser Lys Leu Arg Asn  Met Thr Asp Phe Arg  Leu            
            1035                 1040                 1045                

gca ggc ctt gac  atc aca gat gcc acg  ctt cgc ctc ata att  cgc        4047
Ala Gly Leu Asp  Ile Thr Asp Ala Thr  Leu Arg Leu Ile Ile  Arg            
            1050                 1055                 1060                

cac atg ccc ctc  ctg tct cga ctc gac  ctc agt cac tgc agc  cac        4092
His Met Pro Leu  Leu Ser Arg Leu Asp  Leu Ser His Cys Ser  His            
            1065                 1070                 1075                

ctt aca gat cag  tcc tcc aat cta ctc  act gct gtc ggg tct  tcc        4137
Leu Thr Asp Gln  Ser Ser Asn Leu Leu  Thr Ala Val Gly Ser  Ser            
            1080                 1085                 1090                

act cgc tac tct  ctc aca gag ctc aat  atg gca ggt tgc aat  aaa        4182
Thr Arg Tyr Ser  Leu Thr Glu Leu Asn  Met Ala Gly Cys Asn  Lys            
            1095                 1100                 1105                

ttg aca gac cag  acc ctg atc tac cta  cgg cgc att gcc aac  gtc        4227
Leu Thr Asp Gln  Thr Leu Ile Tyr Leu  Arg Arg Ile Ala Asn  Val            
            1110                 1115                 1120                

acc ttg atc gac  ctt cga gga tgc aag  cag atc act cga aaa  gcc        4272
Thr Leu Ile Asp  Leu Arg Gly Cys Lys  Gln Ile Thr Arg Lys  Ala            
            1125                 1130                 1135                

tgc gag cac ttc  atc tca gac ttg tcc  atc aac agc ctc tac  tgc        4317
Cys Glu His Phe  Ile Ser Asp Leu Ser  Ile Asn Ser Leu Tyr  Cys            
            1140                 1145                 1150                

ctg tct gac gag  aag ctg ata cag aag  atc agc taa gacacaccca          4363
Leu Ser Asp Glu  Lys Leu Ile Gln Lys  Ile Ser                             
            1155                 1160                                     

gcccagattc aacaggaaac cgatcttccc ctgactcccc accgaggaga gcctctcctc     4423

gaccctgcac gggctctgag gccagcgtca cactccctct ctgctctcct gtcccttgag     4483

cccttcctct acaggtgggg cagagagggt ggtggacacc aggcttatct gcctgctcct     4543

ctccctccta aggaaaaggg agtagcagat tgatctgagg ggaaagcaca ggctgtgctg     4603

tcgaggcgcc tgctcgctta ctcgcctgcc aggaggccgg gctctcagtt tggggtgttt     4663

gtgcaacctt catctgcact gggccctgtg cccctcctcc ccatccatgg tccccagcag     4723

tgcctggttc tgagcaaact cccagggaag aaaacggccc tgtctccatg gccaggttct     4783

tgtggtgtcc agtgcgcgtc tctcctccat cacactctcc cggcttgcgc aggaggggcc     4843

agcagcccca ggagtcccag acccgtgccg atcacactgg tgctgttgag atctcccaaa     4903

cctcacgtcc ttaactgtgc tctccctcct ttcctctccc ttgagcttgg ttctgcccag     4963

cactcgtgct tgttcacata attaggtttc ccaccccagc ctacccgact tacttgctag     5023

tctctatgag gtccttattg cacttattgg ggttgaagct cttcagagga gctggaactg     5083

tctaccccag ggacacaccc atttcgttgc tacccaagtg gattctgaga caggcaccat     5143

ctccttgttc cccctctctc ttttgcctcc cactgactgc ccttttccat gtgtcttcat     5203

tctgcctgaa gaaggctttc ccaggatgca cgtcctcaga gggagcagcc tatctccccc     5263

aagctggagg cggcagagga ctgggccaag ccccaacctg cctcccagcc aggctcctcc     5323

aggcctctgg tttagcggag ccccctgagc ccaggcctgt gtctagcccc agtggctcac     5383

tgaactttca gggcagtcag ggggtcctgc ttagaagcca gtcaccagcc ctctgcctgc     5443

agccatggaa gggggtgtgc acgtgcctct gtgtgtgtgg ctgagtgtat tctgcgcgtg     5503

tgtgtggagg gagggaggga ggggagcatg gtgtctcccg ctccaccgcc ctttgttgag     5563

ccccatcagc tgcccccttt tactttgcat tgaacggcct gtccaaagat cctctctcta     5623

gggcagcaga gagctttttg cactttaaaa aaaaaaagaa agaaagaaag gtcggaattt     5683

cttttgggtc aatattttta agtgtgtgag gagatgctca gtagcagcag cctatggcaa     5743

gagcttataa atgattgatg caaatttgca ctctgctccc cctctgtaag gatactgata     5803

gcacaacctc ttccccccac cccgccccgc cttttggtcg tccatccctg tccctttctg     5863

gccctcttcc tgtagcccag tctcaggctt tcctcttcct gaagccctac agagttaggg     5923

aatggagccc aggcaccagg ggtctaaagt gtgagccact gagaagagag acgccaactg     5983

cacccttgcc acttccaaag caatagaggc agagtggtcc cctctttgcc acctaggcca     6043

gttttgaccc tggcattaac tggccttaga agaaactgga tcctggtagg gggtggcatt     6103

ttgtttgttt cttccaatct gctgaatctt ttgactgcac cttacaaaca gcagtctgct     6163

cccatgaccc tctgcccact tccattggtc tccaggcccc aataatctgg ggttgaaact     6223

ttgaggaaat gccagtgact tattccagag tgcctcagtt aggggaactt ctctgtaaag     6283

aaccctgggt attgagcaaa aaccttatta tcgttaatga cctataattg gaagcttcct     6343

gcctttttct ttggttgctc ctgtggaaaa tactgaaaag attactttgt tttattttgt     6403

tgtcttttta taaaagggga ggtggagaga ccccttcaga gcagggattg tgccgggaga     6463

gtgcctctga ctttgggaca tttcatccac agaaatttcc aagccaatgg tttcttttgg     6523

gttttggttt ttatgtttgt tttttggggt ttggaaaaac atgcattttt accgtgcacg     6583

taaattggtc agcagaaaag ggagcccaga aaaggcagca gatggaccat gcccttgctg     6643

ggttttcctt ttctttggga ctgtgagggg aaatggtttt tagaggtgag ggttggtcca     6703

tgtggaggaa agaagtgtct ctgttggggg acagaggaac ctggggagtc catcgcatgt     6763

cctacaatct gctcttagac acggccttgc caggagagcc tgccctcaga ctgcaggacc     6823

agaacccctg cctccatctt tccaagcacc ggggcgaaaa accacaaagg aaaggaagaa     6883

aatttatata tatataatat aaaatcactt ggtgattaaa aaaataactg ctccataaat     6943

aaaactccta aagtcactta tgtttaaagg gtttggttgt gttttttgtt tttcggagaa     7003

atattgtaaa tatatatttt tttgttgctg atttagagtc aatctccaat gttgtgctaa     7063

aaagtttaaa ttaaatgtaa gcattaaggg gataagtctt atgctatctc agttgacaca     7123

ttgaggttat tttgggccag agaaggagga agctagttgg actttgtttt gttttccaaa     7183

agttctccac tattggtttt agagagagca aggacatctt tcctctgaca cgtgggaatg     7243

ggtgatattt gtgtaataaa atttttaaaa gacaaaaaaa gaaatagcct ccaatgggaa     7303

atattttaat ttaggttttg tttttgtttg ggggtttttg tttttttaaa aaaataaaaa     7363

ggctttaaaa acaaaaaaaa aaaaaaaaaa                                      7393


<210>  34
<211>  1162
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Glu Pro Glu Glu Glu Arg Ile Arg Tyr Ser Gln Arg Leu Arg Gly 
1               5                   10                  15      


Thr Met Arg Arg Arg Tyr Glu Asp Asp Gly Ile Ser Asp Asp Glu Ile 
            20                  25                  30          


Glu Gly Lys Arg Thr Phe Asp Leu Glu Glu Lys Leu His Thr Asn Lys 
        35                  40                  45              


Tyr Asn Ala Asn Phe Val Thr Phe Met Glu Gly Lys Asp Phe Asn Val 
    50                  55                  60                  


Glu Tyr Ile Gln Arg Gly Gly Leu Arg Asp Pro Leu Ile Phe Lys Asn 
65                  70                  75                  80  


Ser Asp Gly Leu Gly Ile Lys Met Pro Asp Pro Asp Phe Thr Val Asn 
                85                  90                  95      


Asp Val Lys Met Cys Val Gly Ser Arg Arg Met Val Asp Val Met Asp 
            100                 105                 110         


Val Asn Thr Gln Lys Gly Ile Glu Met Thr Met Ala Gln Trp Thr Arg 
        115                 120                 125             


Tyr Tyr Glu Thr Pro Glu Glu Glu Arg Glu Lys Leu Tyr Asn Val Ile 
    130                 135                 140                 


Ser Leu Glu Phe Ser His Thr Arg Leu Glu Asn Met Val Gln Arg Pro 
145                 150                 155                 160 


Ser Thr Val Asp Phe Ile Asp Trp Val Asp Asn Met Trp Pro Arg His 
                165                 170                 175     


Leu Lys Glu Ser Gln Thr Glu Ser Thr Asn Ala Ile Leu Glu Met Gln 
            180                 185                 190         


Tyr Pro Lys Val Gln Lys Tyr Cys Leu Met Ser Val Arg Gly Cys Tyr 
        195                 200                 205             


Thr Asp Phe His Val Asp Phe Gly Gly Thr Ser Val Trp Tyr His Ile 
    210                 215                 220                 


His Gln Gly Gly Lys Val Phe Trp Leu Ile Pro Pro Thr Ala His Asn 
225                 230                 235                 240 


Leu Glu Leu Tyr Glu Asn Trp Leu Leu Ser Gly Lys Gln Gly Asp Ile 
                245                 250                 255     


Phe Leu Gly Asp Arg Val Ser Asp Cys Gln Arg Ile Glu Leu Lys Gln 
            260                 265                 270         


Gly Tyr Thr Phe Val Ile Pro Ser Gly Trp Ile His Ala Val Tyr Thr 
        275                 280                 285             


Pro Thr Asp Thr Leu Val Phe Gly Gly Asn Phe Leu His Ser Phe Asn 
    290                 295                 300                 


Ile Pro Met Gln Leu Lys Ile Tyr Asn Ile Glu Asp Arg Thr Arg Val 
305                 310                 315                 320 


Pro Asn Lys Phe Arg Tyr Pro Phe Tyr Tyr Glu Met Cys Trp Tyr Val 
                325                 330                 335     


Leu Glu Arg Tyr Val Tyr Cys Ile Thr Asn Arg Ser His Leu Thr Lys 
            340                 345                 350         


Glu Phe Gln Lys Glu Ser Leu Ser Met Asp Leu Glu Leu Asn Gly Leu 
        355                 360                 365             


Glu Ser Gly Asn Gly Asp Glu Glu Ala Val Asp Arg Glu Pro Arg Arg 
    370                 375                 380                 


Leu Ser Ser Arg Arg Ser Val Leu Thr Ser Pro Val Ala Asn Gly Val 
385                 390                 395                 400 


Asn Leu Asp Tyr Asp Gly Leu Gly Lys Thr Cys Arg Ser Leu Pro Ser 
                405                 410                 415     


Leu Lys Lys Thr Leu Ala Gly Asp Ser Ser Ser Asp Cys Ser Arg Gly 
            420                 425                 430         


Ser His Asn Gly Gln Val Trp Asp Pro Gln Cys Ala Pro Arg Lys Asp 
        435                 440                 445             


Arg Gln Val His Leu Thr His Phe Glu Leu Glu Gly Leu Arg Cys Leu 
    450                 455                 460                 


Val Asp Lys Leu Glu Ser Leu Pro Leu His Lys Lys Cys Val Pro Thr 
465                 470                 475                 480 


Gly Ile Glu Asp Glu Asp Ala Leu Ile Ala Asp Val Lys Ile Leu Leu 
                485                 490                 495     


Glu Glu Leu Ala Asn Ser Asp Pro Lys Leu Ala Leu Thr Gly Val Pro 
            500                 505                 510         


Ile Val Gln Trp Pro Lys Arg Asp Lys Leu Lys Phe Pro Thr Arg Pro 
        515                 520                 525             


Lys Val Arg Val Pro Thr Ile Pro Ile Thr Lys Pro His Thr Met Lys 
    530                 535                 540                 


Pro Ala Pro Arg Leu Thr Pro Val Arg Pro Ala Ala Ala Ser Pro Ile 
545                 550                 555                 560 


Val Ser Gly Ala Arg Arg Arg Arg Val Arg Cys Arg Lys Cys Lys Ala 
                565                 570                 575     


Cys Val Gln Gly Glu Cys Gly Val Cys His Tyr Cys Arg Asp Met Lys 
            580                 585                 590         


Lys Phe Gly Gly Pro Gly Arg Met Lys Gln Ser Cys Val Leu Arg Gln 
        595                 600                 605             


Cys Leu Ala Pro Arg Leu Pro His Ser Val Thr Cys Ser Leu Cys Gly 
    610                 615                 620                 


Glu Val Asp Gln Asn Glu Glu Thr Gln Asp Phe Glu Lys Lys Leu Met 
625                 630                 635                 640 


Glu Cys Cys Ile Cys Asn Glu Ile Val His Pro Gly Cys Leu Gln Met 
                645                 650                 655     


Asp Gly Glu Gly Leu Leu Asn Glu Glu Leu Pro Asn Cys Trp Glu Cys 
            660                 665                 670         


Pro Lys Cys Tyr Gln Glu Asp Ser Ser Glu Lys Ala Gln Lys Arg Lys 
        675                 680                 685             


Met Glu Glu Ser Asp Glu Glu Ala Val Gln Ala Lys Val Leu Arg Pro 
    690                 695                 700                 


Leu Arg Ser Cys Asp Glu Pro Leu Thr Pro Pro Pro His Ser Pro Thr 
705                 710                 715                 720 


Ser Met Leu Gln Leu Ile His Asp Pro Val Ser Pro Arg Gly Met Val 
                725                 730                 735     


Thr Arg Ser Ser Pro Gly Ala Gly Pro Ser Asp His His Ser Ala Ser 
            740                 745                 750         


Arg Asp Glu Arg Phe Lys Arg Arg Gln Leu Leu Arg Leu Gln Ala Thr 
        755                 760                 765             


Glu Arg Thr Met Val Arg Glu Lys Glu Asn Asn Pro Ser Gly Lys Lys 
    770                 775                 780                 


Glu Leu Ser Glu Val Glu Lys Ala Lys Ile Arg Gly Ser Tyr Leu Thr 
785                 790                 795                 800 


Val Thr Leu Gln Arg Pro Thr Lys Glu Leu His Gly Thr Ser Ile Val 
                805                 810                 815     


Pro Lys Leu Gln Ala Ile Thr Ala Ser Ser Ala Asn Leu Arg His Ser 
            820                 825                 830         


Pro Arg Val Leu Val Gln His Cys Pro Ala Arg Thr Pro Gln Arg Gly 
        835                 840                 845             


Asp Glu Glu Gly Leu Gly Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    850                 855                 860                 


Glu Glu Asp Asp Ser Ala Glu Glu Gly Gly Ala Ala Arg Leu Asn Gly 
865                 870                 875                 880 


Arg Gly Ser Trp Ala Gln Asp Gly Asp Glu Ser Trp Met Gln Arg Glu 
                885                 890                 895     


Val Trp Met Ser Val Phe Arg Tyr Leu Ser Arg Arg Glu Leu Cys Glu 
            900                 905                 910         


Cys Met Arg Val Cys Lys Thr Trp Tyr Lys Trp Cys Cys Asp Lys Arg 
        915                 920                 925             


Leu Trp Thr Lys Ile Asp Leu Ser Arg Cys Lys Ala Ile Val Pro Gln 
    930                 935                 940                 


Ala Leu Ser Gly Ile Ile Lys Arg Gln Pro Val Ser Leu Asp Leu Ser 
945                 950                 955                 960 


Trp Thr Asn Ile Ser Lys Lys Gln Leu Thr Trp Leu Val Asn Arg Leu 
                965                 970                 975     


Pro Gly Leu Lys Asp Leu Leu Leu Ala Gly Cys Ser Trp Ser Ala Val 
            980                 985                 990         


Ser Ala Leu Ser Thr Ser Ser Cys  Pro Leu Leu Arg Thr  Leu Asp Leu 
        995                 1000                 1005             


Arg Trp  Ala Val Gly Ile Lys  Asp Pro Gln Ile Arg  Asp Leu Leu 
    1010                 1015                 1020             


Thr Pro  Pro Ala Asp Lys Pro  Gly Gln Asp Asn Arg  Ser Lys Leu 
    1025                 1030                 1035             


Arg Asn  Met Thr Asp Phe Arg  Leu Ala Gly Leu Asp  Ile Thr Asp 
    1040                 1045                 1050             


Ala Thr  Leu Arg Leu Ile Ile  Arg His Met Pro Leu  Leu Ser Arg 
    1055                 1060                 1065             


Leu Asp  Leu Ser His Cys Ser  His Leu Thr Asp Gln  Ser Ser Asn 
    1070                 1075                 1080             


Leu Leu  Thr Ala Val Gly Ser  Ser Thr Arg Tyr Ser  Leu Thr Glu 
    1085                 1090                 1095             


Leu Asn  Met Ala Gly Cys Asn  Lys Leu Thr Asp Gln  Thr Leu Ile 
    1100                 1105                 1110             


Tyr Leu  Arg Arg Ile Ala Asn  Val Thr Leu Ile Asp  Leu Arg Gly 
    1115                 1120                 1125             


Cys Lys  Gln Ile Thr Arg Lys  Ala Cys Glu His Phe  Ile Ser Asp 
    1130                 1135                 1140             


Leu Ser  Ile Asn Ser Leu Tyr  Cys Leu Ser Asp Glu  Lys Leu Ile 
    1145                 1150                 1155             


Gln Lys  Ile Ser 
    1160         


<210>  35
<211>  7550
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (13)..(4821)

<400>  35
aagttggatt cc atg ggt tcc aag aga aga aga gct acc tcc cct tcc agc       51
              Met Gly Ser Lys Arg Arg Arg Ala Thr Ser Pro Ser Ser         
              1               5                   10                      

agt gtc agc ggg gac ttt gat gat ggg cac cat tct gtg tca aca cca         99
Ser Val Ser Gly Asp Phe Asp Asp Gly His His Ser Val Ser Thr Pro           
    15                  20                  25                            

ggc cca agc agg aaa agg agg aga ctt tcc aat ctt cca act gta gat        147
Gly Pro Ser Arg Lys Arg Arg Arg Leu Ser Asn Leu Pro Thr Val Asp           
30                  35                  40                  45            

cct att gcc gtg tgc cat gaa ctc tat aat acc atc cga gac tat aag        195
Pro Ile Ala Val Cys His Glu Leu Tyr Asn Thr Ile Arg Asp Tyr Lys           
                50                  55                  60                

gat gaa cag ggc aga ctt ctc tgt gag ctc ttc att agg gca cca aag        243
Asp Glu Gln Gly Arg Leu Leu Cys Glu Leu Phe Ile Arg Ala Pro Lys           
            65                  70                  75                    

cga aga aat caa cca gac tat tat gaa gtg gtt tct cag ccc att gac        291
Arg Arg Asn Gln Pro Asp Tyr Tyr Glu Val Val Ser Gln Pro Ile Asp           
        80                  85                  90                        

ttg atg aaa atc caa cag aaa cta aaa atg gaa gag tat gat gat gtt        339
Leu Met Lys Ile Gln Gln Lys Leu Lys Met Glu Glu Tyr Asp Asp Val           
    95                  100                 105                           

aat ttg ctg act gct gac ttc cag ctt ctt ttt aac aat gca aag tcc        387
Asn Leu Leu Thr Ala Asp Phe Gln Leu Leu Phe Asn Asn Ala Lys Ser           
110                 115                 120                 125           

tat tat aag cca gat tct cct gaa tat aaa gcc gct tgc aaa ctc tgg        435
Tyr Tyr Lys Pro Asp Ser Pro Glu Tyr Lys Ala Ala Cys Lys Leu Trp           
                130                 135                 140               

gat ttg tac ctt cga aca aga aat gag ttt gtt cag aaa gga gaa gca        483
Asp Leu Tyr Leu Arg Thr Arg Asn Glu Phe Val Gln Lys Gly Glu Ala           
            145                 150                 155                   

gat gac gaa gat gat gat gaa gat ggg caa gac aat cag ggc aca gtg        531
Asp Asp Glu Asp Asp Asp Glu Asp Gly Gln Asp Asn Gln Gly Thr Val           
        160                 165                 170                       

act gaa gga tct tct cca gct tac ttg aag gag atc ctg gag cag ctt        579
Thr Glu Gly Ser Ser Pro Ala Tyr Leu Lys Glu Ile Leu Glu Gln Leu           
    175                 180                 185                           

ctt gaa gcc ata gtt gta gct aca aat cca tca gga cgt ctc att agc        627
Leu Glu Ala Ile Val Val Ala Thr Asn Pro Ser Gly Arg Leu Ile Ser           
190                 195                 200                 205           

gaa ctt ttt cag aaa ctg cct tct aaa gtg caa tat cca gat tat tat        675
Glu Leu Phe Gln Lys Leu Pro Ser Lys Val Gln Tyr Pro Asp Tyr Tyr           
                210                 215                 220               

gca ata att aag gag cct ata gat ctc aag acc att gcc cag agg ata        723
Ala Ile Ile Lys Glu Pro Ile Asp Leu Lys Thr Ile Ala Gln Arg Ile           
            225                 230                 235                   

cag aat gga agc tac aaa agt att cat gca atg gcc aaa gat ata gat        771
Gln Asn Gly Ser Tyr Lys Ser Ile His Ala Met Ala Lys Asp Ile Asp           
        240                 245                 250                       

ctc ctc gca aaa aat gcc aaa act tat aat gag cct ggc tct caa gta        819
Leu Leu Ala Lys Asn Ala Lys Thr Tyr Asn Glu Pro Gly Ser Gln Val           
    255                 260                 265                           

ttc aag gat gca aat tca att aaa aaa ata ttt tat atg aaa aag gct        867
Phe Lys Asp Ala Asn Ser Ile Lys Lys Ile Phe Tyr Met Lys Lys Ala           
270                 275                 280                 285           

gaa att gaa cat cat gaa atg gct aag tca agt ctt cga atg agt aat        915
Glu Ile Glu His His Glu Met Ala Lys Ser Ser Leu Arg Met Ser Asn           
                290                 295                 300               

aaa aga gca gta caa gga ggt cgt tta tca gca att aca atg gca ctt        963
Lys Arg Ala Val Gln Gly Gly Arg Leu Ser Ala Ile Thr Met Ala Leu           
            305                 310                 315                   

caa tat ggc tca gaa agt gaa gaa gat gct gct tta gct gct gca cgc       1011
Gln Tyr Gly Ser Glu Ser Glu Glu Asp Ala Ala Leu Ala Ala Ala Arg           
        320                 325                 330                       

tat gaa gag gga gag tca gaa gca gaa agc atc act tcc ttt atg gat       1059
Tyr Glu Glu Gly Glu Ser Glu Ala Glu Ser Ile Thr Ser Phe Met Asp           
    335                 340                 345                           

gtt tca aat cct ttt tat cag ctt tat gac aca gtt agg agt tgt cgg       1107
Val Ser Asn Pro Phe Tyr Gln Leu Tyr Asp Thr Val Arg Ser Cys Arg           
350                 355                 360                 365           

aat aac caa ggg cag cta ata gct gaa cct ttt tac cat ttg cct tca       1155
Asn Asn Gln Gly Gln Leu Ile Ala Glu Pro Phe Tyr His Leu Pro Ser           
                370                 375                 380               

aag aaa aaa tac cct gat tat tac cag caa att aaa atg ccc ata tca       1203
Lys Lys Lys Tyr Pro Asp Tyr Tyr Gln Gln Ile Lys Met Pro Ile Ser           
            385                 390                 395                   

cta caa cag atc cga aca aaa ctg aag aat caa gaa tat gaa act tta       1251
Leu Gln Gln Ile Arg Thr Lys Leu Lys Asn Gln Glu Tyr Glu Thr Leu           
        400                 405                 410                       

gat cat ttg gag tgt gat ctg aat tta atg ttt gaa aat gcc aaa cgc       1299
Asp His Leu Glu Cys Asp Leu Asn Leu Met Phe Glu Asn Ala Lys Arg           
    415                 420                 425                           

tat aat gtg ccc aat tca gcc atc tac aag cga gtt cta aaa ttg cag       1347
Tyr Asn Val Pro Asn Ser Ala Ile Tyr Lys Arg Val Leu Lys Leu Gln           
430                 435                 440                 445           

caa gtt atg cag gca aag aag aaa gag ctt gcc agg aga gac gat atc       1395
Gln Val Met Gln Ala Lys Lys Lys Glu Leu Ala Arg Arg Asp Asp Ile           
                450                 455                 460               

gag gac gga gac agc atg atc tct tca gcc acc tct gat act ggt agt       1443
Glu Asp Gly Asp Ser Met Ile Ser Ser Ala Thr Ser Asp Thr Gly Ser           
            465                 470                 475                   

gcc aaa aga aaa agt aaa aag aac ata aga aag cag cga atg aaa atc       1491
Ala Lys Arg Lys Ser Lys Lys Asn Ile Arg Lys Gln Arg Met Lys Ile           
        480                 485                 490                       

tta ttc aat gtt gtt ctt gaa gct cga gag cca ggt tca ggc aga aga       1539
Leu Phe Asn Val Val Leu Glu Ala Arg Glu Pro Gly Ser Gly Arg Arg           
    495                 500                 505                           

ctt tgt gac cta ttt atg gtt aaa cca tcc aaa aag gac tat cct gat       1587
Leu Cys Asp Leu Phe Met Val Lys Pro Ser Lys Lys Asp Tyr Pro Asp           
510                 515                 520                 525           

tat tat aaa atc atc ttg gag cca atg gac ttg aaa ata att gag cat       1635
Tyr Tyr Lys Ile Ile Leu Glu Pro Met Asp Leu Lys Ile Ile Glu His           
                530                 535                 540               

aac atc cgc aat gac aaa tat gct ggt gaa gag gga atg ata gaa gac       1683
Asn Ile Arg Asn Asp Lys Tyr Ala Gly Glu Glu Gly Met Ile Glu Asp           
            545                 550                 555                   

atg aag ctg atg ttc cgg aat gcc agg cac tat aat gag gag ggc tcc       1731
Met Lys Leu Met Phe Arg Asn Ala Arg His Tyr Asn Glu Glu Gly Ser           
        560                 565                 570                       

cag gtt tat aat gat gca cat atc ctg gag aag tta ctc aag gag aaa       1779
Gln Val Tyr Asn Asp Ala His Ile Leu Glu Lys Leu Leu Lys Glu Lys           
    575                 580                 585                           

agg aaa gag ctg ggc cca ctg cct gat gat gat gac atg gct tct ccc       1827
Arg Lys Glu Leu Gly Pro Leu Pro Asp Asp Asp Asp Met Ala Ser Pro           
590                 595                 600                 605           

aaa ctc aag ctg agt agg aag agt ggc att tct cct aaa aaa tca aaa       1875
Lys Leu Lys Leu Ser Arg Lys Ser Gly Ile Ser Pro Lys Lys Ser Lys           
                610                 615                 620               

tac atg act cca atg cag cag aaa cta aat gag gtc tat gaa gct gta       1923
Tyr Met Thr Pro Met Gln Gln Lys Leu Asn Glu Val Tyr Glu Ala Val           
            625                 630                 635                   

aag aac tat act gat aag agg ggt cgc cgc ctc agt gcc ata ttt ctg       1971
Lys Asn Tyr Thr Asp Lys Arg Gly Arg Arg Leu Ser Ala Ile Phe Leu           
        640                 645                 650                       

agg ctt ccc tct aga tct gag ttg cct gac tac tat ctg act att aaa       2019
Arg Leu Pro Ser Arg Ser Glu Leu Pro Asp Tyr Tyr Leu Thr Ile Lys           
    655                 660                 665                           

aag ccc atg gac atg gaa aaa att cga agt cac atg atg gcc aac aag       2067
Lys Pro Met Asp Met Glu Lys Ile Arg Ser His Met Met Ala Asn Lys           
670                 675                 680                 685           

tac caa gat att gac tct atg gtt gag gac ttt gtc atg atg ttt aat       2115
Tyr Gln Asp Ile Asp Ser Met Val Glu Asp Phe Val Met Met Phe Asn           
                690                 695                 700               

aat gcc tgt aca tac aat gag ccg gag tct ttg atc tac aaa gat gct       2163
Asn Ala Cys Thr Tyr Asn Glu Pro Glu Ser Leu Ile Tyr Lys Asp Ala           
            705                 710                 715                   

ctt gtt cta cac aaa gtc ctg ctt gaa aca cgc aga gac ctg gag gga       2211
Leu Val Leu His Lys Val Leu Leu Glu Thr Arg Arg Asp Leu Glu Gly           
        720                 725                 730                       

gat gag gac tct cat gtc cca aat gtg act ttg ctg att caa gag ctt       2259
Asp Glu Asp Ser His Val Pro Asn Val Thr Leu Leu Ile Gln Glu Leu           
    735                 740                 745                           

atc cac aat ctt ttt gtg tca gtc atg agt cat cag gat gat gag gga       2307
Ile His Asn Leu Phe Val Ser Val Met Ser His Gln Asp Asp Glu Gly           
750                 755                 760                 765           

aga tgc tac agc gat tct tta gca gaa att cct gct gtg gat ccc aac       2355
Arg Cys Tyr Ser Asp Ser Leu Ala Glu Ile Pro Ala Val Asp Pro Asn           
                770                 775                 780               

ttt cct aac aaa cca ccc ctt aca ttt gac ata att agg aag aat gtt       2403
Phe Pro Asn Lys Pro Pro Leu Thr Phe Asp Ile Ile Arg Lys Asn Val           
            785                 790                 795                   

gaa aat aat cgc tac cgt cgg ctt gat tta ttt caa gag cat atg ttt       2451
Glu Asn Asn Arg Tyr Arg Arg Leu Asp Leu Phe Gln Glu His Met Phe           
        800                 805                 810                       

gaa gta ttg gaa cga gca aga agg atg aat cgg aca gat tca gaa ata       2499
Glu Val Leu Glu Arg Ala Arg Arg Met Asn Arg Thr Asp Ser Glu Ile           
    815                 820                 825                           

tat gaa gat gca gta gaa ctt cag cag ttt ttt att aaa att cgt gat       2547
Tyr Glu Asp Ala Val Glu Leu Gln Gln Phe Phe Ile Lys Ile Arg Asp           
830                 835                 840                 845           

gaa ctc tgc aaa aat gga gag att ctt ctt tca ccg gca ctc agc tat       2595
Glu Leu Cys Lys Asn Gly Glu Ile Leu Leu Ser Pro Ala Leu Ser Tyr           
                850                 855                 860               

acc aca aaa cat ttg cat aat gat gtg gag aaa gag aga aag gaa aaa       2643
Thr Thr Lys His Leu His Asn Asp Val Glu Lys Glu Arg Lys Glu Lys           
            865                 870                 875                   

ttg cca aaa gaa ata gag gaa gat aaa cta aaa cga gaa gaa gaa aaa       2691
Leu Pro Lys Glu Ile Glu Glu Asp Lys Leu Lys Arg Glu Glu Glu Lys           
        880                 885                 890                       

aga gaa gct gaa aag agt gaa gat tcc tct ggt gct gca ggc ctc tca       2739
Arg Glu Ala Glu Lys Ser Glu Asp Ser Ser Gly Ala Ala Gly Leu Ser           
    895                 900                 905                           

ggc tta cat cgc aca tac agc cag gac tgt agc ttt aaa aac agc atg       2787
Gly Leu His Arg Thr Tyr Ser Gln Asp Cys Ser Phe Lys Asn Ser Met           
910                 915                 920                 925           

tac cat gtt gga gat tac gtc tat gtg gaa cct gca gag gcc aac cta       2835
Tyr His Val Gly Asp Tyr Val Tyr Val Glu Pro Ala Glu Ala Asn Leu           
                930                 935                 940               

caa cca cat atc gtc tgt att gaa aga ctg tgg gag gat tca gct ggt       2883
Gln Pro His Ile Val Cys Ile Glu Arg Leu Trp Glu Asp Ser Ala Gly           
            945                 950                 955                   

gaa aaa tgg ttg tat ggc tgt tgg ttt tac cga cca aat gaa aca ttc       2931
Glu Lys Trp Leu Tyr Gly Cys Trp Phe Tyr Arg Pro Asn Glu Thr Phe           
        960                 965                 970                       

cac ctg gct aca cga aaa ttt cta gaa aaa gaa gtt ttt aag agt gac       2979
His Leu Ala Thr Arg Lys Phe Leu Glu Lys Glu Val Phe Lys Ser Asp           
    975                 980                 985                           

tat tac aac aaa gtt cca gtt agt aaa att cta  ggc aag tgt gtg gtc      3027
Tyr Tyr Asn Lys Val Pro Val Ser Lys Ile Leu  Gly Lys Cys Val Val          
990                 995                 1000                 1005         

atg ttt gtc aag gaa  tac ttt aag tta tgc  cca gaa aac ttc cga         3072
Met Phe Val Lys Glu  Tyr Phe Lys Leu Cys  Pro Glu Asn Phe Arg             
                1010                 1015                 1020            

gat gag gat gtt ttt  gtc tgt gaa tca cgg  tat tct gcc aaa acc         3117
Asp Glu Asp Val Phe  Val Cys Glu Ser Arg  Tyr Ser Ala Lys Thr             
                1025                 1030                 1035            

aaa tct ttt aag aaa  att aaa ctg tgg acc  atg ccc atc agc tca         3162
Lys Ser Phe Lys Lys  Ile Lys Leu Trp Thr  Met Pro Ile Ser Ser             
                1040                 1045                 1050            

gtc agg ttt gtc cct  cgg gat gtg cct ctg  cct gtg gtt cgc gtg         3207
Val Arg Phe Val Pro  Arg Asp Val Pro Leu  Pro Val Val Arg Val             
                1055                 1060                 1065            

gcc tct gta ttt gca  aat gca gat aaa ggt  gat gat gag aag aat         3252
Ala Ser Val Phe Ala  Asn Ala Asp Lys Gly  Asp Asp Glu Lys Asn             
                1070                 1075                 1080            

aca gac aac tca gag  gac agt cga gct gaa  gac aat ttt aac ttg         3297
Thr Asp Asn Ser Glu  Asp Ser Arg Ala Glu  Asp Asn Phe Asn Leu             
                1085                 1090                 1095            

gaa aag gaa aaa gaa  gat gtc cct gtg gaa  atg tcc aat ggt gaa         3342
Glu Lys Glu Lys Glu  Asp Val Pro Val Glu  Met Ser Asn Gly Glu             
                1100                 1105                 1110            

cca ggt tgc cac tac  ttt gag cag ctc cat  tac aat gac atg tgg         3387
Pro Gly Cys His Tyr  Phe Glu Gln Leu His  Tyr Asn Asp Met Trp             
                1115                 1120                 1125            

ctg aag gtt ggc gac  tgt gtc ttc atc aag  tcc cat ggc ctg gtg         3432
Leu Lys Val Gly Asp  Cys Val Phe Ile Lys  Ser His Gly Leu Val             
                1130                 1135                 1140            

cgt cct cgt gtg ggc  aga att gaa aaa gta  tgg gtt cga gat gga         3477
Arg Pro Arg Val Gly  Arg Ile Glu Lys Val  Trp Val Arg Asp Gly             
                1145                 1150                 1155            

gct gca tat ttt tat  ggc ccc atc ttc att  cac cca gaa gaa aca         3522
Ala Ala Tyr Phe Tyr  Gly Pro Ile Phe Ile  His Pro Glu Glu Thr             
                1160                 1165                 1170            

gag cat gag ccc aca  aaa atg ttc tac aaa  aaa gaa gta ttt ctg         3567
Glu His Glu Pro Thr  Lys Met Phe Tyr Lys  Lys Glu Val Phe Leu             
                1175                 1180                 1185            

agt aat ctg gaa gaa  acc tgc ccc atg aca  tgt att ctc gga aag         3612
Ser Asn Leu Glu Glu  Thr Cys Pro Met Thr  Cys Ile Leu Gly Lys             
                1190                 1195                 1200            

tgt gct gtg ttg tca  ttc aag gac ttc ctc  tcc tgc agg cca act         3657
Cys Ala Val Leu Ser  Phe Lys Asp Phe Leu  Ser Cys Arg Pro Thr             
                1205                 1210                 1215            

gaa ata cca gaa aat  gac att ctg ctt tgt  gag agc cgc tac aat         3702
Glu Ile Pro Glu Asn  Asp Ile Leu Leu Cys  Glu Ser Arg Tyr Asn             
                1220                 1225                 1230            

gag agc gac aag cag  atg aag aaa ttc aaa  gga ttg aag agg ttt         3747
Glu Ser Asp Lys Gln  Met Lys Lys Phe Lys  Gly Leu Lys Arg Phe             
                1235                 1240                 1245            

tca ctc tct gct aaa  gtg gta gat gat gaa  att tac tac ttc aga         3792
Ser Leu Ser Ala Lys  Val Val Asp Asp Glu  Ile Tyr Tyr Phe Arg             
                1250                 1255                 1260            

aaa cca att gtt cct  cag aag gag cca tca  cct ttg ctg gaa aag         3837
Lys Pro Ile Val Pro  Gln Lys Glu Pro Ser  Pro Leu Leu Glu Lys             
                1265                 1270                 1275            

aag atc cag ttg cta  gaa gct aaa ttt gcc  gag tta gaa ggt gga         3882
Lys Ile Gln Leu Leu  Glu Ala Lys Phe Ala  Glu Leu Glu Gly Gly             
                1280                 1285                 1290            

gat gat gat att gaa  gag atg gga gaa gaa  gat agt gag gtc att         3927
Asp Asp Asp Ile Glu  Glu Met Gly Glu Glu  Asp Ser Glu Val Ile             
                1295                 1300                 1305            

gaa cct cct tct cta  cct cag ctt cag acc  ccc ctg gcc agt gag         3972
Glu Pro Pro Ser Leu  Pro Gln Leu Gln Thr  Pro Leu Ala Ser Glu             
                1310                 1315                 1320            

ctg gac ctc atg ccc  tac aca ccc cca cag  tct acc cca aag tct         4017
Leu Asp Leu Met Pro  Tyr Thr Pro Pro Gln  Ser Thr Pro Lys Ser             
                1325                 1330                 1335            

gcc aaa ggc agt gca  aag aag gaa ggc tcc  aaa cgg aaa atc aac         4062
Ala Lys Gly Ser Ala  Lys Lys Glu Gly Ser  Lys Arg Lys Ile Asn             
                1340                 1345                 1350            

atg agt ggc tac atc  ctg ttc agc agt gag  atg agg gct gtg att         4107
Met Ser Gly Tyr Ile  Leu Phe Ser Ser Glu  Met Arg Ala Val Ile             
                1355                 1360                 1365            

aag gcc caa cac cca  gac tac tct ttc ggg  gag ctc agc cgc ctg         4152
Lys Ala Gln His Pro  Asp Tyr Ser Phe Gly  Glu Leu Ser Arg Leu             
                1370                 1375                 1380            

gtg ggg aca gaa tgg  aga aat ctt gag aca  gcc aag aaa gca gaa         4197
Val Gly Thr Glu Trp  Arg Asn Leu Glu Thr  Ala Lys Lys Ala Glu             
                1385                 1390                 1395            

tat gaa ggc atg atg  ggt ggc tat ccg cca  ggc ctt cca cct ttg         4242
Tyr Glu Gly Met Met  Gly Gly Tyr Pro Pro  Gly Leu Pro Pro Leu             
                1400                 1405                 1410            

cag ggc cca gtt gat  ggc ctt gtt agc atg  ggc agc atg cag cca         4287
Gln Gly Pro Val Asp  Gly Leu Val Ser Met  Gly Ser Met Gln Pro             
                1415                 1420                 1425            

ctt cac cct ggg ggg  cct cca ccc cac cat  ctt ccg cca ggt gtg         4332
Leu His Pro Gly Gly  Pro Pro Pro His His  Leu Pro Pro Gly Val             
                1430                 1435                 1440            

cct ggc ctc ccg ggc  atc cca cca ccg ggt  gtg atg aac caa gga         4377
Pro Gly Leu Pro Gly  Ile Pro Pro Pro Gly  Val Met Asn Gln Gly             
                1445                 1450                 1455            

gtg gcc cct atg gta  ggg act cca gca cca  ggt gga agt cca tat         4422
Val Ala Pro Met Val  Gly Thr Pro Ala Pro  Gly Gly Ser Pro Tyr             
                1460                 1465                 1470            

gga caa cag gtg gga  gtt ttg ggg cct cca  ggg cag cag gca cca         4467
Gly Gln Gln Val Gly  Val Leu Gly Pro Pro  Gly Gln Gln Ala Pro             
                1475                 1480                 1485            

cct cca tat ccc ggc  cca cat cca gct gga  ccc cct gtc ata cag         4512
Pro Pro Tyr Pro Gly  Pro His Pro Ala Gly  Pro Pro Val Ile Gln             
                1490                 1495                 1500            

cag cca aca aca ccc  atg ttt gta gct ccc  cca cca aag acc cag         4557
Gln Pro Thr Thr Pro  Met Phe Val Ala Pro  Pro Pro Lys Thr Gln             
                1505                 1510                 1515            

cgg ctt ctt cac tca  gag gcc tac ctg aaa  tac att gaa gga ctc         4602
Arg Leu Leu His Ser  Glu Ala Tyr Leu Lys  Tyr Ile Glu Gly Leu             
                1520                 1525                 1530            

agt gcg gag tcc aac  agc att agc aag tgg  gat cag aca ctg gca         4647
Ser Ala Glu Ser Asn  Ser Ile Ser Lys Trp  Asp Gln Thr Leu Ala             
                1535                 1540                 1545            

gct cga aga cgc gac  gtc cat ttg tcg aaa  gaa cag gag agc cgc         4692
Ala Arg Arg Arg Asp  Val His Leu Ser Lys  Glu Gln Glu Ser Arg             
                1550                 1555                 1560            

cta ccc tct cac tgg  ctg aaa agc aaa ggg  gcc cac acc acc atg         4737
Leu Pro Ser His Trp  Leu Lys Ser Lys Gly  Ala His Thr Thr Met             
                1565                 1570                 1575            

gca gat gcc ctc tgg  cgc ctt cga gat ttg  atg ctc cgg gac acc         4782
Ala Asp Ala Leu Trp  Arg Leu Arg Asp Leu  Met Leu Arg Asp Thr             
                1580                 1585                 1590            

ctc aac att cgc caa  gca tac aac cta gaa  aat gtt taa tcacatcatt      4831
Leu Asn Ile Arg Gln  Ala Tyr Asn Leu Glu  Asn Val                         
                1595                 1600                                 

acgtttcttt tatatagaag cataaagagt tgtggatcag tagccatttt agttactggg     4891

ggtgggggga aggaacaaag gaggataatt tttattgcat tttactgtac atcacaaggc     4951

catttttata tacggacact tttaataagc tatttcaatt tgtttgttat attaagttga     5011

ctttatcaaa tacacaaaga tttttttgca tatgtttcct tcgtttaaaa ccagtttcat     5071

aattggttgt atatgtagac ttggagtttt atctttttac ttgttgccat ggaactgaaa     5131

ccattagagg tttttgtctt ggcttggggt ttttgttttc ttggttttgg gtttttttat     5191

atatatatat aaaagaacaa aatgaaaaaa aacacacaca cacaagagtt tacagattag     5251

tttaaattga taatgaaatg tgaagtttgt cctagtttac atcttagaga ggggagtata     5311

cttgtgtttg tttcatgtgc ctgaatatct taagccactt tctgcaaaag ctgtttctta     5371

cagatgaagt gctttctttg aaaggtggtt atttaggttt tagatgttta atagacacag     5431

cacatttgct ctattaactc agaggctcac tacagaaata tgtaatcagt gctgtgcatc     5491

tgtctgcagc taatgtacct cctggacacc aggaggggaa aaagcacttt ttcaattgtg     5551

ctgagttaga catctgtgag ttagactatg gtgtcagtga tttttgcaga acacgtgcac     5611

aaccctgagg tatgtttaat ctaggcaggt acgtttaagg atattttgat ctatttataa     5671

tgaattcaca atttatgcct ataaatttca gatgatttaa aattttaaac ctgttacatt     5731

gaaaaacatt gaagttcgtc ttgaagaaag cattaaggta tgcatggagg tgatttattt     5791

ttaaacataa cacctaacct aacatgggta agagagtatg gaactagata tgagctgtat     5851

aagaagcata attgtgaaca agtagattga ttgccttcat atacaagtat gttttagtat     5911

tccttatttc cttattatca gatgtatttt ttcttttaag tttcaatgtt gttataattc     5971

tcaaccagaa atttaatact ttctaaaata ttttttaaat ttagcttgtg cttttgaatt     6031

acaggagaag ggaatcataa tttaataaaa cgcttactag aaagaccatt acagatccca     6091

aacacttggg tttggtgacc ctgtctttct tatatgaccc tacaataaac atttgaaggc     6151

agcataggat ggcagacagt aggaacattg tttcacttgg cggcatgttt ttgaaacctg     6211

ctttatagta actgggtgat tgccattgtg gtagagcttc cactgctgtt tataatctga     6271

gagagttaat ctcagaggat gcttttttcc ttttaatctg ctatgaatca gtacccagat     6331

gtttaattac tgtacttatt aaatcatgag ggcaaaagag tgtagaatgg aaaaaagtct     6391

cttgtatcta gatactttaa atatgggagg ccctttaact taattgcctt tagtcaacca     6451

ctggatttga atttgcatca agtattttaa ataatattga atttaaaaaa atgtattgca     6511

gtagtgtgtc agtaccttat tgttaaagtg agtcagataa atcttcaatt cctggctatt     6571

tgggcaattg aatcatcatg gactgtataa tgcaatcaga ttattttgtt tctagacatc     6631

cttgaattac accaaagaac atgaaattta gttgtggtta aattatttat ttatttcatg     6691

cattcatttt atttccctta aggtctggat gagacttctt tggggagcct ctaaaaaaat     6751

ttttcactgg gggccacgtg ggtcattaga agccagagct ctcctccagg ctccttccca     6811

gtgcctagag gtgctatagg aaacatagat ccagccaggg gcttccctaa agcagtgcag     6871

caccggccca gggcatcact agacaggccc taattaagtt ttttttaaaa agcctgtgta     6931

tttattttag aatcatgttt ttctgtatat taacttgggg gatatcgtta atatttagga     6991

tataagattt gaggtcagcc atcttcaaaa aagaaaaaaa aattgactca agaaagtaca     7051

agtaaactat acaccttttt ttcataagtt ttaggaactg tagtaatgtg gcttagaaag     7111

tataatggcc taaatgtttt caaaatgtaa gttcctgtgg agaagaattg tttatattgc     7171

aaacgggggg actgagggga acctgtaggt ttaaaacagt atgtttgtca gccaactgat     7231

ttaaaaggcc tttaactgtt ttggttgttg tttttttttt aagccactct ccccttccta     7291

tgaggaagaa ttgagagggg cacctatttc tgtaaaatcc ccaaattggt gttgatgatt     7351

ttgagcttga atgttttcat acctgattaa aacttggttt attctaattt ctgtatcata     7411

tcatctgagg tttacgtggt aactagtctt ataacatgta tgtatctttt ttttgttgtt     7471

catctaaagc tttttaatcc aaataaatac agagtttgca aagtgatttg gattaaccag     7531

gaaaaaaaaa aaaaaaaaa                                                  7550


<210>  36
<211>  1602
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Ser Lys Arg Arg Arg Ala Thr Ser Pro Ser Ser Ser Val Ser 
1               5                   10                  15      


Gly Asp Phe Asp Asp Gly His His Ser Val Ser Thr Pro Gly Pro Ser 
            20                  25                  30          


Arg Lys Arg Arg Arg Leu Ser Asn Leu Pro Thr Val Asp Pro Ile Ala 
        35                  40                  45              


Val Cys His Glu Leu Tyr Asn Thr Ile Arg Asp Tyr Lys Asp Glu Gln 
    50                  55                  60                  


Gly Arg Leu Leu Cys Glu Leu Phe Ile Arg Ala Pro Lys Arg Arg Asn 
65                  70                  75                  80  


Gln Pro Asp Tyr Tyr Glu Val Val Ser Gln Pro Ile Asp Leu Met Lys 
                85                  90                  95      


Ile Gln Gln Lys Leu Lys Met Glu Glu Tyr Asp Asp Val Asn Leu Leu 
            100                 105                 110         


Thr Ala Asp Phe Gln Leu Leu Phe Asn Asn Ala Lys Ser Tyr Tyr Lys 
        115                 120                 125             


Pro Asp Ser Pro Glu Tyr Lys Ala Ala Cys Lys Leu Trp Asp Leu Tyr 
    130                 135                 140                 


Leu Arg Thr Arg Asn Glu Phe Val Gln Lys Gly Glu Ala Asp Asp Glu 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Gly Gln Asp Asn Gln Gly Thr Val Thr Glu Gly 
                165                 170                 175     


Ser Ser Pro Ala Tyr Leu Lys Glu Ile Leu Glu Gln Leu Leu Glu Ala 
            180                 185                 190         


Ile Val Val Ala Thr Asn Pro Ser Gly Arg Leu Ile Ser Glu Leu Phe 
        195                 200                 205             


Gln Lys Leu Pro Ser Lys Val Gln Tyr Pro Asp Tyr Tyr Ala Ile Ile 
    210                 215                 220                 


Lys Glu Pro Ile Asp Leu Lys Thr Ile Ala Gln Arg Ile Gln Asn Gly 
225                 230                 235                 240 


Ser Tyr Lys Ser Ile His Ala Met Ala Lys Asp Ile Asp Leu Leu Ala 
                245                 250                 255     


Lys Asn Ala Lys Thr Tyr Asn Glu Pro Gly Ser Gln Val Phe Lys Asp 
            260                 265                 270         


Ala Asn Ser Ile Lys Lys Ile Phe Tyr Met Lys Lys Ala Glu Ile Glu 
        275                 280                 285             


His His Glu Met Ala Lys Ser Ser Leu Arg Met Ser Asn Lys Arg Ala 
    290                 295                 300                 


Val Gln Gly Gly Arg Leu Ser Ala Ile Thr Met Ala Leu Gln Tyr Gly 
305                 310                 315                 320 


Ser Glu Ser Glu Glu Asp Ala Ala Leu Ala Ala Ala Arg Tyr Glu Glu 
                325                 330                 335     


Gly Glu Ser Glu Ala Glu Ser Ile Thr Ser Phe Met Asp Val Ser Asn 
            340                 345                 350         


Pro Phe Tyr Gln Leu Tyr Asp Thr Val Arg Ser Cys Arg Asn Asn Gln 
        355                 360                 365             


Gly Gln Leu Ile Ala Glu Pro Phe Tyr His Leu Pro Ser Lys Lys Lys 
    370                 375                 380                 


Tyr Pro Asp Tyr Tyr Gln Gln Ile Lys Met Pro Ile Ser Leu Gln Gln 
385                 390                 395                 400 


Ile Arg Thr Lys Leu Lys Asn Gln Glu Tyr Glu Thr Leu Asp His Leu 
                405                 410                 415     


Glu Cys Asp Leu Asn Leu Met Phe Glu Asn Ala Lys Arg Tyr Asn Val 
            420                 425                 430         


Pro Asn Ser Ala Ile Tyr Lys Arg Val Leu Lys Leu Gln Gln Val Met 
        435                 440                 445             


Gln Ala Lys Lys Lys Glu Leu Ala Arg Arg Asp Asp Ile Glu Asp Gly 
    450                 455                 460                 


Asp Ser Met Ile Ser Ser Ala Thr Ser Asp Thr Gly Ser Ala Lys Arg 
465                 470                 475                 480 


Lys Ser Lys Lys Asn Ile Arg Lys Gln Arg Met Lys Ile Leu Phe Asn 
                485                 490                 495     


Val Val Leu Glu Ala Arg Glu Pro Gly Ser Gly Arg Arg Leu Cys Asp 
            500                 505                 510         


Leu Phe Met Val Lys Pro Ser Lys Lys Asp Tyr Pro Asp Tyr Tyr Lys 
        515                 520                 525             


Ile Ile Leu Glu Pro Met Asp Leu Lys Ile Ile Glu His Asn Ile Arg 
    530                 535                 540                 


Asn Asp Lys Tyr Ala Gly Glu Glu Gly Met Ile Glu Asp Met Lys Leu 
545                 550                 555                 560 


Met Phe Arg Asn Ala Arg His Tyr Asn Glu Glu Gly Ser Gln Val Tyr 
                565                 570                 575     


Asn Asp Ala His Ile Leu Glu Lys Leu Leu Lys Glu Lys Arg Lys Glu 
            580                 585                 590         


Leu Gly Pro Leu Pro Asp Asp Asp Asp Met Ala Ser Pro Lys Leu Lys 
        595                 600                 605             


Leu Ser Arg Lys Ser Gly Ile Ser Pro Lys Lys Ser Lys Tyr Met Thr 
    610                 615                 620                 


Pro Met Gln Gln Lys Leu Asn Glu Val Tyr Glu Ala Val Lys Asn Tyr 
625                 630                 635                 640 


Thr Asp Lys Arg Gly Arg Arg Leu Ser Ala Ile Phe Leu Arg Leu Pro 
                645                 650                 655     


Ser Arg Ser Glu Leu Pro Asp Tyr Tyr Leu Thr Ile Lys Lys Pro Met 
            660                 665                 670         


Asp Met Glu Lys Ile Arg Ser His Met Met Ala Asn Lys Tyr Gln Asp 
        675                 680                 685             


Ile Asp Ser Met Val Glu Asp Phe Val Met Met Phe Asn Asn Ala Cys 
    690                 695                 700                 


Thr Tyr Asn Glu Pro Glu Ser Leu Ile Tyr Lys Asp Ala Leu Val Leu 
705                 710                 715                 720 


His Lys Val Leu Leu Glu Thr Arg Arg Asp Leu Glu Gly Asp Glu Asp 
                725                 730                 735     


Ser His Val Pro Asn Val Thr Leu Leu Ile Gln Glu Leu Ile His Asn 
            740                 745                 750         


Leu Phe Val Ser Val Met Ser His Gln Asp Asp Glu Gly Arg Cys Tyr 
        755                 760                 765             


Ser Asp Ser Leu Ala Glu Ile Pro Ala Val Asp Pro Asn Phe Pro Asn 
    770                 775                 780                 


Lys Pro Pro Leu Thr Phe Asp Ile Ile Arg Lys Asn Val Glu Asn Asn 
785                 790                 795                 800 


Arg Tyr Arg Arg Leu Asp Leu Phe Gln Glu His Met Phe Glu Val Leu 
                805                 810                 815     


Glu Arg Ala Arg Arg Met Asn Arg Thr Asp Ser Glu Ile Tyr Glu Asp 
            820                 825                 830         


Ala Val Glu Leu Gln Gln Phe Phe Ile Lys Ile Arg Asp Glu Leu Cys 
        835                 840                 845             


Lys Asn Gly Glu Ile Leu Leu Ser Pro Ala Leu Ser Tyr Thr Thr Lys 
    850                 855                 860                 


His Leu His Asn Asp Val Glu Lys Glu Arg Lys Glu Lys Leu Pro Lys 
865                 870                 875                 880 


Glu Ile Glu Glu Asp Lys Leu Lys Arg Glu Glu Glu Lys Arg Glu Ala 
                885                 890                 895     


Glu Lys Ser Glu Asp Ser Ser Gly Ala Ala Gly Leu Ser Gly Leu His 
            900                 905                 910         


Arg Thr Tyr Ser Gln Asp Cys Ser Phe Lys Asn Ser Met Tyr His Val 
        915                 920                 925             


Gly Asp Tyr Val Tyr Val Glu Pro Ala Glu Ala Asn Leu Gln Pro His 
    930                 935                 940                 


Ile Val Cys Ile Glu Arg Leu Trp Glu Asp Ser Ala Gly Glu Lys Trp 
945                 950                 955                 960 


Leu Tyr Gly Cys Trp Phe Tyr Arg Pro Asn Glu Thr Phe His Leu Ala 
                965                 970                 975     


Thr Arg Lys Phe Leu Glu Lys Glu Val Phe Lys Ser Asp Tyr Tyr Asn 
            980                 985                 990         


Lys Val Pro Val Ser Lys Ile Leu  Gly Lys Cys Val Val  Met Phe Val 
        995                 1000                 1005             


Lys Glu  Tyr Phe Lys Leu Cys  Pro Glu Asn Phe Arg  Asp Glu Asp 
    1010                 1015                 1020             


Val Phe  Val Cys Glu Ser Arg  Tyr Ser Ala Lys Thr  Lys Ser Phe 
    1025                 1030                 1035             


Lys Lys  Ile Lys Leu Trp Thr  Met Pro Ile Ser Ser  Val Arg Phe 
    1040                 1045                 1050             


Val Pro  Arg Asp Val Pro Leu  Pro Val Val Arg Val  Ala Ser Val 
    1055                 1060                 1065             


Phe Ala  Asn Ala Asp Lys Gly  Asp Asp Glu Lys Asn  Thr Asp Asn 
    1070                 1075                 1080             


Ser Glu  Asp Ser Arg Ala Glu  Asp Asn Phe Asn Leu  Glu Lys Glu 
    1085                 1090                 1095             


Lys Glu  Asp Val Pro Val Glu  Met Ser Asn Gly Glu  Pro Gly Cys 
    1100                 1105                 1110             


His Tyr  Phe Glu Gln Leu His  Tyr Asn Asp Met Trp  Leu Lys Val 
    1115                 1120                 1125             


Gly Asp  Cys Val Phe Ile Lys  Ser His Gly Leu Val  Arg Pro Arg 
    1130                 1135                 1140             


Val Gly  Arg Ile Glu Lys Val  Trp Val Arg Asp Gly  Ala Ala Tyr 
    1145                 1150                 1155             


Phe Tyr  Gly Pro Ile Phe Ile  His Pro Glu Glu Thr  Glu His Glu 
    1160                 1165                 1170             


Pro Thr  Lys Met Phe Tyr Lys  Lys Glu Val Phe Leu  Ser Asn Leu 
    1175                 1180                 1185             


Glu Glu  Thr Cys Pro Met Thr  Cys Ile Leu Gly Lys  Cys Ala Val 
    1190                 1195                 1200             


Leu Ser  Phe Lys Asp Phe Leu  Ser Cys Arg Pro Thr  Glu Ile Pro 
    1205                 1210                 1215             


Glu Asn  Asp Ile Leu Leu Cys  Glu Ser Arg Tyr Asn  Glu Ser Asp 
    1220                 1225                 1230             


Lys Gln  Met Lys Lys Phe Lys  Gly Leu Lys Arg Phe  Ser Leu Ser 
    1235                 1240                 1245             


Ala Lys  Val Val Asp Asp Glu  Ile Tyr Tyr Phe Arg  Lys Pro Ile 
    1250                 1255                 1260             


Val Pro  Gln Lys Glu Pro Ser  Pro Leu Leu Glu Lys  Lys Ile Gln 
    1265                 1270                 1275             


Leu Leu  Glu Ala Lys Phe Ala  Glu Leu Glu Gly Gly  Asp Asp Asp 
    1280                 1285                 1290             


Ile Glu  Glu Met Gly Glu Glu  Asp Ser Glu Val Ile  Glu Pro Pro 
    1295                 1300                 1305             


Ser Leu  Pro Gln Leu Gln Thr  Pro Leu Ala Ser Glu  Leu Asp Leu 
    1310                 1315                 1320             


Met Pro  Tyr Thr Pro Pro Gln  Ser Thr Pro Lys Ser  Ala Lys Gly 
    1325                 1330                 1335             


Ser Ala  Lys Lys Glu Gly Ser  Lys Arg Lys Ile Asn  Met Ser Gly 
    1340                 1345                 1350             


Tyr Ile  Leu Phe Ser Ser Glu  Met Arg Ala Val Ile  Lys Ala Gln 
    1355                 1360                 1365             


His Pro  Asp Tyr Ser Phe Gly  Glu Leu Ser Arg Leu  Val Gly Thr 
    1370                 1375                 1380             


Glu Trp  Arg Asn Leu Glu Thr  Ala Lys Lys Ala Glu  Tyr Glu Gly 
    1385                 1390                 1395             


Met Met  Gly Gly Tyr Pro Pro  Gly Leu Pro Pro Leu  Gln Gly Pro 
    1400                 1405                 1410             


Val Asp  Gly Leu Val Ser Met  Gly Ser Met Gln Pro  Leu His Pro 
    1415                 1420                 1425             


Gly Gly  Pro Pro Pro His His  Leu Pro Pro Gly Val  Pro Gly Leu 
    1430                 1435                 1440             


Pro Gly  Ile Pro Pro Pro Gly  Val Met Asn Gln Gly  Val Ala Pro 
    1445                 1450                 1455             


Met Val  Gly Thr Pro Ala Pro  Gly Gly Ser Pro Tyr  Gly Gln Gln 
    1460                 1465                 1470             


Val Gly  Val Leu Gly Pro Pro  Gly Gln Gln Ala Pro  Pro Pro Tyr 
    1475                 1480                 1485             


Pro Gly  Pro His Pro Ala Gly  Pro Pro Val Ile Gln  Gln Pro Thr 
    1490                 1495                 1500             


Thr Pro  Met Phe Val Ala Pro  Pro Pro Lys Thr Gln  Arg Leu Leu 
    1505                 1510                 1515             


His Ser  Glu Ala Tyr Leu Lys  Tyr Ile Glu Gly Leu  Ser Ala Glu 
    1520                 1525                 1530             


Ser Asn  Ser Ile Ser Lys Trp  Asp Gln Thr Leu Ala  Ala Arg Arg 
    1535                 1540                 1545             


Arg Asp  Val His Leu Ser Lys  Glu Gln Glu Ser Arg  Leu Pro Ser 
    1550                 1555                 1560             


His Trp  Leu Lys Ser Lys Gly  Ala His Thr Thr Met  Ala Asp Ala 
    1565                 1570                 1575             


Leu Trp  Arg Leu Arg Asp Leu  Met Leu Arg Asp Thr  Leu Asn Ile 
    1580                 1585                 1590             


Arg Gln  Ala Tyr Asn Leu Glu  Asn Val 
    1595                 1600         


<210>  37
<211>  4652
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (61)..(3627)

<400>  37
gtgagaacta ggagcctgtc ctccatgttt tataagtatt gacattacac agtgttaaca       60

atg cat cca cag agc ttg gct gaa gag gaa ata aaa aca gaa cag gag        108
Met His Pro Gln Ser Leu Ala Glu Glu Glu Ile Lys Thr Glu Gln Glu           
1               5                   10                  15                

gtg gta gag ggc atg gat atc tct act cgc tcc aaa gat cct ggc tct        156
Val Val Glu Gly Met Asp Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser           
            20                  25                  30                    

gca gag aga aca gcc cag aaa aga aag ttc ccc agc cct cca cat tct        204
Ala Glu Arg Thr Ala Gln Lys Arg Lys Phe Pro Ser Pro Pro His Ser           
        35                  40                  45                        

tcc aat ggc cac tcg ccg cag gac aca tca aca agc ccc att aaa aag        252
Ser Asn Gly His Ser Pro Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys           
    50                  55                  60                            

aaa aag aaa cct ggc tta ctg aac agt aac aat aag gag cag tca gaa        300
Lys Lys Lys Pro Gly Leu Leu Asn Ser Asn Asn Lys Glu Gln Ser Glu           
65                  70                  75                  80            

cta aga cat ggt ccg ttt tac tat atg aag cag cca ctc acc aca gac        348
Leu Arg His Gly Pro Phe Tyr Tyr Met Lys Gln Pro Leu Thr Thr Asp           
                85                  90                  95                

cct gtt gat gtt gta ccg cag gat gga cgg aat gat ttc tac tgc tgg        396
Pro Val Asp Val Val Pro Gln Asp Gly Arg Asn Asp Phe Tyr Cys Trp           
            100                 105                 110                   

gtt tgt cac cgg gaa ggc caa gtc ctt tgc tgt gag ctc tgt ccc cgg        444
Val Cys His Arg Glu Gly Gln Val Leu Cys Cys Glu Leu Cys Pro Arg           
        115                 120                 125                       

gtt tat cac gct aag tgt ctg aga ctg aca tcg gaa cca gag ggg gac        492
Val Tyr His Ala Lys Cys Leu Arg Leu Thr Ser Glu Pro Glu Gly Asp           
    130                 135                 140                           

tgg ttt tgt cct gaa tgt gag aaa att aca gta gca gaa tgc atc gag        540
Trp Phe Cys Pro Glu Cys Glu Lys Ile Thr Val Ala Glu Cys Ile Glu           
145                 150                 155                 160           

acc cag agt aaa gcc atg aca atg ctc acc att gaa cag tta tcc tac        588
Thr Gln Ser Lys Ala Met Thr Met Leu Thr Ile Glu Gln Leu Ser Tyr           
                165                 170                 175               

ctg ctc aag ttt gcc att cag aaa atg aaa cag cca ggg aca gat gca        636
Leu Leu Lys Phe Ala Ile Gln Lys Met Lys Gln Pro Gly Thr Asp Ala           
            180                 185                 190                   

ttc cag aag ccc gtt cca ttg gaa cag cac cct gac tat gcg gaa tac        684
Phe Gln Lys Pro Val Pro Leu Glu Gln His Pro Asp Tyr Ala Glu Tyr           
        195                 200                 205                       

atc ttc cat cca atg gac ctt tgt aca ttg gaa aag aat gcg aaa aag        732
Ile Phe His Pro Met Asp Leu Cys Thr Leu Glu Lys Asn Ala Lys Lys           
    210                 215                 220                           

aaa atg tat ggc tgc aca gaa gcc ttc ctg gct gat gca aag tgg att        780
Lys Met Tyr Gly Cys Thr Glu Ala Phe Leu Ala Asp Ala Lys Trp Ile           
225                 230                 235                 240           

ttg cac aac tgc atc att tat aat ggg gga aat cac aaa ttg acg caa        828
Leu His Asn Cys Ile Ile Tyr Asn Gly Gly Asn His Lys Leu Thr Gln           
                245                 250                 255               

ata gcg aaa gta gtc atc aaa atc tgt gaa cat gag atg aat gaa atc        876
Ile Ala Lys Val Val Ile Lys Ile Cys Glu His Glu Met Asn Glu Ile           
            260                 265                 270                   

gaa gta tgt cca gaa tgt tat cta gct gct tgc caa aaa cga gat aac        924
Glu Val Cys Pro Glu Cys Tyr Leu Ala Ala Cys Gln Lys Arg Asp Asn           
        275                 280                 285                       

tgg ttt tgt gag cct tgt agc aat cca cat cct ttg gtc tgg gcc aaa        972
Trp Phe Cys Glu Pro Cys Ser Asn Pro His Pro Leu Val Trp Ala Lys           
    290                 295                 300                           

ctg aag ggg ttt cca ttc tgg cct gca aaa gct cta agg gat aaa gac       1020
Leu Lys Gly Phe Pro Phe Trp Pro Ala Lys Ala Leu Arg Asp Lys Asp           
305                 310                 315                 320           

ggg cag gtc gat gcc cga ttc ttt gga caa cat gac agg gcc tgg gtt       1068
Gly Gln Val Asp Ala Arg Phe Phe Gly Gln His Asp Arg Ala Trp Val           
                325                 330                 335               

cca ata aat aat tgc tac ctc atg tct aaa gaa att cct ttt tct gtg       1116
Pro Ile Asn Asn Cys Tyr Leu Met Ser Lys Glu Ile Pro Phe Ser Val           
            340                 345                 350                   

aaa aag act aag agc atc ttc aac agt gcc atg caa gag atg gag gtt       1164
Lys Lys Thr Lys Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu Val           
        355                 360                 365                       

tac gtg gag aac atc cgc agg aag ttt ggg gtt ttt aat tac tct cca       1212
Tyr Val Glu Asn Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser Pro           
    370                 375                 380                           

ttt agg aca ccc tac aca ccc aac agc cag tat caa atg ctg ctc gat       1260
Phe Arg Thr Pro Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu Asp           
385                 390                 395                 400           

ccc acc aac ccc agc gcc ggc act gcc aag ata gac aag cag gag aag       1308
Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu Lys           
                405                 410                 415               

gtc aag ctc aac ttt gac atg acg gca tcc ccc aag atc ctg atg agc       1356
Val Lys Leu Asn Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met Ser           
            420                 425                 430                   

aag cct gtg ctg agt ggg ggc aca ggc cgc cgg att tcc ttg tcg gat       1404
Lys Pro Val Leu Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser Asp           
        435                 440                 445                       

atg ccg cgc tcc ccc atg agc aca aac tct tct gtg cac acg ggc tcc       1452
Met Pro Arg Ser Pro Met Ser Thr Asn Ser Ser Val His Thr Gly Ser           
    450                 455                 460                           

gac gtg gag cag gat gct gag aag aag gcc acg tcg agc cac ttc agt       1500
Asp Val Glu Gln Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe Ser           
465                 470                 475                 480           

gcg agc gag gag tcc atg gac ttc ctg gat aag agc aca gct tca cca       1548
Ala Ser Glu Glu Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser Pro           
                485                 490                 495               

gcc tcc acc aag acg gga caa gca ggg agt tta tcc ggc agc cca aag       1596
Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro Lys           
            500                 505                 510                   

ccc ttc tct cct caa ctg tca gct cct atc acg acg aaa acg gac aaa       1644
Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp Lys           
        515                 520                 525                       

acc tcc acc acc ggc agc atc ctg aat ctt aac ctg gat cga agc aaa       1692
Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser Lys           
    530                 535                 540                           

gct gag atg gat ttg aag gag ctg agc gag tcg gtc cag caa cag tcc       1740
Ala Glu Met Asp Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln Ser           
545                 550                 555                 560           

acc cct gtt cct ctc atc tct ccc aag cgc cag att cgt agc agg ttc       1788
Thr Pro Val Pro Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg Phe           
                565                 570                 575               

cag ctg aat ctt gac aag acc ata gag agt tgc aaa gca caa tta ggc       1836
Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu Gly           
            580                 585                 590                   

ata aat gaa atc tcg gaa gat gtc tat acg gcc gta gag cac agc gat       1884
Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser Asp           
        595                 600                 605                       

tcg gag gat tct gag aag tca gat agt agc gat agt gag tat atc agt       1932
Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile Ser           
    610                 615                 620                           

gat gat gag cag aag tct aag aac gag cca gaa gac aca gag gac aaa       1980
Asp Asp Glu Gln Lys Ser Lys Asn Glu Pro Glu Asp Thr Glu Asp Lys           
625                 630                 635                 640           

gaa ggt tgt cag atg gac aaa gag cca tct gct gtt aaa aaa aag ccc       2028
Glu Gly Cys Gln Met Asp Lys Glu Pro Ser Ala Val Lys Lys Lys Pro           
                645                 650                 655               

aag cct aca aac cca gtg gag att aaa gag gag ctg aaa agc acg tca       2076
Lys Pro Thr Asn Pro Val Glu Ile Lys Glu Glu Leu Lys Ser Thr Ser           
            660                 665                 670                   

cca gcc agc gag aag gca gac cct gga gca gtc aag gac aag gcc agc       2124
Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala Val Lys Asp Lys Ala Ser           
        675                 680                 685                       

cct gag cct gag aag gac ttt tcc gaa aag gca aaa cct tca cct cac       2172
Pro Glu Pro Glu Lys Asp Phe Ser Glu Lys Ala Lys Pro Ser Pro His           
    690                 695                 700                           

ccc ata aag gat aaa ctg aag gga aaa gat gag acg gat tcc cca aca       2220
Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser Pro Thr           
705                 710                 715                 720           

gtc cat ttg ggc ctg gac tct gat tca gag agc gaa ctt gtc ata gat       2268
Val His Leu Gly Leu Asp Ser Asp Ser Glu Ser Glu Leu Val Ile Asp           
                725                 730                 735               

tta gga gaa gac cat tct ggg cgg gag ggt cga aaa aat aag aag gaa       2316
Leu Gly Glu Asp His Ser Gly Arg Glu Gly Arg Lys Asn Lys Lys Glu           
            740                 745                 750                   

ccc aaa gaa cca tct ccc aaa cag gat gtt gta ggt aaa act cca cca       2364
Pro Lys Glu Pro Ser Pro Lys Gln Asp Val Val Gly Lys Thr Pro Pro           
        755                 760                 765                       

tcc acg acg gtg ggc agc cat tct ccc ccg gaa aca ccg gtg ctc acc       2412
Ser Thr Thr Val Gly Ser His Ser Pro Pro Glu Thr Pro Val Leu Thr           
    770                 775                 780                           

cgc tct tcc gcc caa act tcc gcg gct ggc gcc aca gcc acc acc agc       2460
Arg Ser Ser Ala Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr Thr Ser           
785                 790                 795                 800           

acg tcc tcc acg gtc acc gtc acg gcc ccg gcc ccc gcc gcc aca gga       2508
Thr Ser Ser Thr Val Thr Val Thr Ala Pro Ala Pro Ala Ala Thr Gly           
                805                 810                 815               

agc cca gtg aaa aag cag agg ccg ctt tta ccg aag gag act gcc ccg       2556
Ser Pro Val Lys Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr Ala Pro           
            820                 825                 830                   

gcc gtg cag cgg gtc gtg tgg aac tca tca act gtc cag cag aag gag       2604
Ala Val Gln Arg Val Val Trp Asn Ser Ser Thr Val Gln Gln Lys Glu           
        835                 840                 845                       

atc aca cag agc cca tcc acg tcc acc atc acc ctg gtg acc agc aca       2652
Ile Thr Gln Ser Pro Ser Thr Ser Thr Ile Thr Leu Val Thr Ser Thr           
    850                 855                 860                           

cag tca tcg ccc ctg gtc acc agc tcg ggg tcc atg agc acc ctt gtg       2700
Gln Ser Ser Pro Leu Val Thr Ser Ser Gly Ser Met Ser Thr Leu Val           
865                 870                 875                 880           

tcc tca gtc aac gct gac ctg ccc atc gcc act gcc tca gct gat gtc       2748
Ser Ser Val Asn Ala Asp Leu Pro Ile Ala Thr Ala Ser Ala Asp Val           
                885                 890                 895               

gcc gct gat att gcc aag tac act agc aaa atg atg gat gca ata aaa       2796
Ala Ala Asp Ile Ala Lys Tyr Thr Ser Lys Met Met Asp Ala Ile Lys           
            900                 905                 910                   

gga aca atg aca gaa ata tac aac gat ctt tct aaa aac act act gga       2844
Gly Thr Met Thr Glu Ile Tyr Asn Asp Leu Ser Lys Asn Thr Thr Gly           
        915                 920                 925                       

agc aca ata gct gag att cgc agg ctg agg atc gag ata gag aag ctc       2892
Ser Thr Ile Ala Glu Ile Arg Arg Leu Arg Ile Glu Ile Glu Lys Leu           
    930                 935                 940                           

cag tgg ctg cac cag caa gag ctc tcc gaa atg aaa cac aac tta gag       2940
Gln Trp Leu His Gln Gln Glu Leu Ser Glu Met Lys His Asn Leu Glu           
945                 950                 955                 960           

ctg acc atg gcg gag atg cgg cag agc ctg gag cag gag cgg gac cgg       2988
Leu Thr Met Ala Glu Met Arg Gln Ser Leu Glu Gln Glu Arg Asp Arg           
                965                 970                 975               

ctc atc gcc gag gtg aag aag cag ctg gag ttg gag aag cag cag gcg       3036
Leu Ile Ala Glu Val Lys Lys Gln Leu Glu Leu Glu Lys Gln Gln Ala           
            980                 985                 990                   

gtg gat gag acc aag aag aag cag  tgg tgc gcc aac tgc  aag aag gag     3084
Val Asp Glu Thr Lys Lys Lys Gln  Trp Cys Ala Asn Cys  Lys Lys Glu         
        995                 1000                 1005                     

gcc atc  ttt tac tgc tgt tgg  aac act agc tac tgt  gac tac ccc        3129
Ala Ile  Phe Tyr Cys Cys Trp  Asn Thr Ser Tyr Cys  Asp Tyr Pro            
    1010                 1015                 1020                        

tgc cag  caa gcc cac tgg cct  gag cac atg aag tcc  tgc acc cag        3174
Cys Gln  Gln Ala His Trp Pro  Glu His Met Lys Ser  Cys Thr Gln            
    1025                 1030                 1035                        

tca gct  act gct cct cag cag  gaa gcg gat gct gag  gtg aac aca        3219
Ser Ala  Thr Ala Pro Gln Gln  Glu Ala Asp Ala Glu  Val Asn Thr            
    1040                 1045                 1050                        

gaa aca  cta aat aag tcc tcc  cag ggg agc tcc tcg  agc aca caa        3264
Glu Thr  Leu Asn Lys Ser Ser  Gln Gly Ser Ser Ser  Ser Thr Gln            
    1055                 1060                 1065                        

tca gca  cct tca gaa acg gcc  agc gcc tcc aaa gag  aag gag acg        3309
Ser Ala  Pro Ser Glu Thr Ala  Ser Ala Ser Lys Glu  Lys Glu Thr            
    1070                 1075                 1080                        

tca gct  gag aaa agc aag gag  agt ggc tcg acc ctt  gac ctt tct        3354
Ser Ala  Glu Lys Ser Lys Glu  Ser Gly Ser Thr Leu  Asp Leu Ser            
    1085                 1090                 1095                        

ggc tcc  aga gag acg ccc tcc  tcc att ctc tta ggc  tcc aac caa        3399
Gly Ser  Arg Glu Thr Pro Ser  Ser Ile Leu Leu Gly  Ser Asn Gln            
    1100                 1105                 1110                        

ggc tct  gtt agc aaa agg tgt  gac aag caa cct gcc  tat gcc cca        3444
Gly Ser  Val Ser Lys Arg Cys  Asp Lys Gln Pro Ala  Tyr Ala Pro            
    1115                 1120                 1125                        

acc acc  aca gac cac cag ccg  cac ccc aac tac ccc  gcc cag aag        3489
Thr Thr  Thr Asp His Gln Pro  His Pro Asn Tyr Pro  Ala Gln Lys            
    1130                 1135                 1140                        

tac cat  tcc cgg agt aat aaa  tcc agt tgg agc agc  agt gat gag        3534
Tyr His  Ser Arg Ser Asn Lys  Ser Ser Trp Ser Ser  Ser Asp Glu            
    1145                 1150                 1155                        

aag agg  gga tcg aca cgt tcc  gat cac aac acc agt  acc agc acg        3579
Lys Arg  Gly Ser Thr Arg Ser  Asp His Asn Thr Ser  Thr Ser Thr            
    1160                 1165                 1170                        

aag agc  ctc ctc ccg aaa gag  tct cgg ctg gac acc  ttc tgg gac        3624
Lys Ser  Leu Leu Pro Lys Glu  Ser Arg Leu Asp Thr  Phe Trp Asp            
    1175                 1180                 1185                        

tag cagtgaatcg ggacacaaac cacccacccc attgggagaa aaacccagac            3677

gccaggaaaa gaagaaacaa caaaggcagg agaacagcca ctttcagact tgaaaatgac     3737

aaaaccctca gttgagcctg agcccccggc gcgggggctg ctacactaca ggacacccag     3797

catcggcttt gactgcagac tgttcaccca cacgagccct gtgcttttgg tgtaaataat     3857

gtacaatttg tggatgtcat tgaatctaga ggactttccc ctttttatat ttgtattaac     3917

tttaacttat taaaaaaaaa aaaagaaaaa gaaaaacgat ttaaaaaaaa aaaaaaaagc     3977

aaccaacccc aacaacaaaa aagaatgttt tggtattgga gaagggatgg tcagttagcc     4037

tgtctgtcac acgacggaat ggatactggg cccggggacc actttcatac tcacgtcctc     4097

atccttggat acccagggga gggcgaaccg ttttcgctcg tgtgtctgta cgcagcatgt     4157

tgggatcggg agtttcggca cagactatcc catcaagccg ttggctcctt tcagctacta     4217

cgttaccacg ttcctaaaac gcaagctctc cggaccagac ggacacaggg agaagctagt     4277

ttctttcatg tgattgaaat gatgactcta ctcctaaaag ggaaaaaaca atatccttgt     4337

ttacagaaga gaaacaaaca agccccactc agctcagtca caggagagaa cacagaaagt     4397

cttaggatca tgaactctga aaaaaagaga aaccttatct ttgctttgtg gttcctttaa     4457

acacactcac acacacttgg tcagagatgc tgtgcttctt ggaagcaagg actcaaaggc     4517

aaggtgcacg cagaggacgt ttgagtctgg gatgaagcat gtacgtatta tttatatgat     4577

ggaatttcac gtttttatgt aagcatgaaa cacaggcagt atgagagaaa gcaaggcccg     4637

tcatgctgtc cgtac                                                      4652


<210>  38
<211>  1188
<212>  PRT
<213>  Homo sapiens

<400>  38

Met His Pro Gln Ser Leu Ala Glu Glu Glu Ile Lys Thr Glu Gln Glu 
1               5                   10                  15      


Val Val Glu Gly Met Asp Ile Ser Thr Arg Ser Lys Asp Pro Gly Ser 
            20                  25                  30          


Ala Glu Arg Thr Ala Gln Lys Arg Lys Phe Pro Ser Pro Pro His Ser 
        35                  40                  45              


Ser Asn Gly His Ser Pro Gln Asp Thr Ser Thr Ser Pro Ile Lys Lys 
    50                  55                  60                  


Lys Lys Lys Pro Gly Leu Leu Asn Ser Asn Asn Lys Glu Gln Ser Glu 
65                  70                  75                  80  


Leu Arg His Gly Pro Phe Tyr Tyr Met Lys Gln Pro Leu Thr Thr Asp 
                85                  90                  95      


Pro Val Asp Val Val Pro Gln Asp Gly Arg Asn Asp Phe Tyr Cys Trp 
            100                 105                 110         


Val Cys His Arg Glu Gly Gln Val Leu Cys Cys Glu Leu Cys Pro Arg 
        115                 120                 125             


Val Tyr His Ala Lys Cys Leu Arg Leu Thr Ser Glu Pro Glu Gly Asp 
    130                 135                 140                 


Trp Phe Cys Pro Glu Cys Glu Lys Ile Thr Val Ala Glu Cys Ile Glu 
145                 150                 155                 160 


Thr Gln Ser Lys Ala Met Thr Met Leu Thr Ile Glu Gln Leu Ser Tyr 
                165                 170                 175     


Leu Leu Lys Phe Ala Ile Gln Lys Met Lys Gln Pro Gly Thr Asp Ala 
            180                 185                 190         


Phe Gln Lys Pro Val Pro Leu Glu Gln His Pro Asp Tyr Ala Glu Tyr 
        195                 200                 205             


Ile Phe His Pro Met Asp Leu Cys Thr Leu Glu Lys Asn Ala Lys Lys 
    210                 215                 220                 


Lys Met Tyr Gly Cys Thr Glu Ala Phe Leu Ala Asp Ala Lys Trp Ile 
225                 230                 235                 240 


Leu His Asn Cys Ile Ile Tyr Asn Gly Gly Asn His Lys Leu Thr Gln 
                245                 250                 255     


Ile Ala Lys Val Val Ile Lys Ile Cys Glu His Glu Met Asn Glu Ile 
            260                 265                 270         


Glu Val Cys Pro Glu Cys Tyr Leu Ala Ala Cys Gln Lys Arg Asp Asn 
        275                 280                 285             


Trp Phe Cys Glu Pro Cys Ser Asn Pro His Pro Leu Val Trp Ala Lys 
    290                 295                 300                 


Leu Lys Gly Phe Pro Phe Trp Pro Ala Lys Ala Leu Arg Asp Lys Asp 
305                 310                 315                 320 


Gly Gln Val Asp Ala Arg Phe Phe Gly Gln His Asp Arg Ala Trp Val 
                325                 330                 335     


Pro Ile Asn Asn Cys Tyr Leu Met Ser Lys Glu Ile Pro Phe Ser Val 
            340                 345                 350         


Lys Lys Thr Lys Ser Ile Phe Asn Ser Ala Met Gln Glu Met Glu Val 
        355                 360                 365             


Tyr Val Glu Asn Ile Arg Arg Lys Phe Gly Val Phe Asn Tyr Ser Pro 
    370                 375                 380                 


Phe Arg Thr Pro Tyr Thr Pro Asn Ser Gln Tyr Gln Met Leu Leu Asp 
385                 390                 395                 400 


Pro Thr Asn Pro Ser Ala Gly Thr Ala Lys Ile Asp Lys Gln Glu Lys 
                405                 410                 415     


Val Lys Leu Asn Phe Asp Met Thr Ala Ser Pro Lys Ile Leu Met Ser 
            420                 425                 430         


Lys Pro Val Leu Ser Gly Gly Thr Gly Arg Arg Ile Ser Leu Ser Asp 
        435                 440                 445             


Met Pro Arg Ser Pro Met Ser Thr Asn Ser Ser Val His Thr Gly Ser 
    450                 455                 460                 


Asp Val Glu Gln Asp Ala Glu Lys Lys Ala Thr Ser Ser His Phe Ser 
465                 470                 475                 480 


Ala Ser Glu Glu Ser Met Asp Phe Leu Asp Lys Ser Thr Ala Ser Pro 
                485                 490                 495     


Ala Ser Thr Lys Thr Gly Gln Ala Gly Ser Leu Ser Gly Ser Pro Lys 
            500                 505                 510         


Pro Phe Ser Pro Gln Leu Ser Ala Pro Ile Thr Thr Lys Thr Asp Lys 
        515                 520                 525             


Thr Ser Thr Thr Gly Ser Ile Leu Asn Leu Asn Leu Asp Arg Ser Lys 
    530                 535                 540                 


Ala Glu Met Asp Leu Lys Glu Leu Ser Glu Ser Val Gln Gln Gln Ser 
545                 550                 555                 560 


Thr Pro Val Pro Leu Ile Ser Pro Lys Arg Gln Ile Arg Ser Arg Phe 
                565                 570                 575     


Gln Leu Asn Leu Asp Lys Thr Ile Glu Ser Cys Lys Ala Gln Leu Gly 
            580                 585                 590         


Ile Asn Glu Ile Ser Glu Asp Val Tyr Thr Ala Val Glu His Ser Asp 
        595                 600                 605             


Ser Glu Asp Ser Glu Lys Ser Asp Ser Ser Asp Ser Glu Tyr Ile Ser 
    610                 615                 620                 


Asp Asp Glu Gln Lys Ser Lys Asn Glu Pro Glu Asp Thr Glu Asp Lys 
625                 630                 635                 640 


Glu Gly Cys Gln Met Asp Lys Glu Pro Ser Ala Val Lys Lys Lys Pro 
                645                 650                 655     


Lys Pro Thr Asn Pro Val Glu Ile Lys Glu Glu Leu Lys Ser Thr Ser 
            660                 665                 670         


Pro Ala Ser Glu Lys Ala Asp Pro Gly Ala Val Lys Asp Lys Ala Ser 
        675                 680                 685             


Pro Glu Pro Glu Lys Asp Phe Ser Glu Lys Ala Lys Pro Ser Pro His 
    690                 695                 700                 


Pro Ile Lys Asp Lys Leu Lys Gly Lys Asp Glu Thr Asp Ser Pro Thr 
705                 710                 715                 720 


Val His Leu Gly Leu Asp Ser Asp Ser Glu Ser Glu Leu Val Ile Asp 
                725                 730                 735     


Leu Gly Glu Asp His Ser Gly Arg Glu Gly Arg Lys Asn Lys Lys Glu 
            740                 745                 750         


Pro Lys Glu Pro Ser Pro Lys Gln Asp Val Val Gly Lys Thr Pro Pro 
        755                 760                 765             


Ser Thr Thr Val Gly Ser His Ser Pro Pro Glu Thr Pro Val Leu Thr 
    770                 775                 780                 


Arg Ser Ser Ala Gln Thr Ser Ala Ala Gly Ala Thr Ala Thr Thr Ser 
785                 790                 795                 800 


Thr Ser Ser Thr Val Thr Val Thr Ala Pro Ala Pro Ala Ala Thr Gly 
                805                 810                 815     


Ser Pro Val Lys Lys Gln Arg Pro Leu Leu Pro Lys Glu Thr Ala Pro 
            820                 825                 830         


Ala Val Gln Arg Val Val Trp Asn Ser Ser Thr Val Gln Gln Lys Glu 
        835                 840                 845             


Ile Thr Gln Ser Pro Ser Thr Ser Thr Ile Thr Leu Val Thr Ser Thr 
    850                 855                 860                 


Gln Ser Ser Pro Leu Val Thr Ser Ser Gly Ser Met Ser Thr Leu Val 
865                 870                 875                 880 


Ser Ser Val Asn Ala Asp Leu Pro Ile Ala Thr Ala Ser Ala Asp Val 
                885                 890                 895     


Ala Ala Asp Ile Ala Lys Tyr Thr Ser Lys Met Met Asp Ala Ile Lys 
            900                 905                 910         


Gly Thr Met Thr Glu Ile Tyr Asn Asp Leu Ser Lys Asn Thr Thr Gly 
        915                 920                 925             


Ser Thr Ile Ala Glu Ile Arg Arg Leu Arg Ile Glu Ile Glu Lys Leu 
    930                 935                 940                 


Gln Trp Leu His Gln Gln Glu Leu Ser Glu Met Lys His Asn Leu Glu 
945                 950                 955                 960 


Leu Thr Met Ala Glu Met Arg Gln Ser Leu Glu Gln Glu Arg Asp Arg 
                965                 970                 975     


Leu Ile Ala Glu Val Lys Lys Gln Leu Glu Leu Glu Lys Gln Gln Ala 
            980                 985                 990         


Val Asp Glu Thr Lys Lys Lys Gln  Trp Cys Ala Asn Cys  Lys Lys Glu 
        995                 1000                 1005             


Ala Ile  Phe Tyr Cys Cys Trp  Asn Thr Ser Tyr Cys  Asp Tyr Pro 
    1010                 1015                 1020             


Cys Gln  Gln Ala His Trp Pro  Glu His Met Lys Ser  Cys Thr Gln 
    1025                 1030                 1035             


Ser Ala  Thr Ala Pro Gln Gln  Glu Ala Asp Ala Glu  Val Asn Thr 
    1040                 1045                 1050             


Glu Thr  Leu Asn Lys Ser Ser  Gln Gly Ser Ser Ser  Ser Thr Gln 
    1055                 1060                 1065             


Ser Ala  Pro Ser Glu Thr Ala  Ser Ala Ser Lys Glu  Lys Glu Thr 
    1070                 1075                 1080             


Ser Ala  Glu Lys Ser Lys Glu  Ser Gly Ser Thr Leu  Asp Leu Ser 
    1085                 1090                 1095             


Gly Ser  Arg Glu Thr Pro Ser  Ser Ile Leu Leu Gly  Ser Asn Gln 
    1100                 1105                 1110             


Gly Ser  Val Ser Lys Arg Cys  Asp Lys Gln Pro Ala  Tyr Ala Pro 
    1115                 1120                 1125             


Thr Thr  Thr Asp His Gln Pro  His Pro Asn Tyr Pro  Ala Gln Lys 
    1130                 1135                 1140             


Tyr His  Ser Arg Ser Asn Lys  Ser Ser Trp Ser Ser  Ser Asp Glu 
    1145                 1150                 1155             


Lys Arg  Gly Ser Thr Arg Ser  Asp His Asn Thr Ser  Thr Ser Thr 
    1160                 1165                 1170             


Lys Ser  Leu Leu Pro Lys Glu  Ser Arg Leu Asp Thr  Phe Trp Asp 
    1175                 1180                 1185             


<210>  39
<211>  2272
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (44)..(1678)

<400>  39
gcgcggccag gactgtctga ggggaagttc gcgagcgctg gct atg ggt cct ggg         55
                                                Met Gly Pro Gly           
                                                1                         

gcg cgg ctg gcg gcg ctg ctg gcg gtg ctg gcg ctc ggg aca gga gac        103
Ala Arg Leu Ala Ala Leu Leu Ala Val Leu Ala Leu Gly Thr Gly Asp           
5                   10                  15                  20            

cca gaa agg gct gcg gct cgg ggc gac acg ttc tcg gcg ctg acc agc        151
Pro Glu Arg Ala Ala Ala Arg Gly Asp Thr Phe Ser Ala Leu Thr Ser           
                25                  30                  35                

gtg gcg cgc gcc ctg gcg ccc gag cgc cgg ctg ctg ggg ctg ctg agg        199
Val Ala Arg Ala Leu Ala Pro Glu Arg Arg Leu Leu Gly Leu Leu Arg           
            40                  45                  50                    

cgg tac ctg cgc ggg gag gag gcg cgg ctg cgg gac ctg act aga ttc        247
Arg Tyr Leu Arg Gly Glu Glu Ala Arg Leu Arg Asp Leu Thr Arg Phe           
        55                  60                  65                        

tac gac aag gta ctt tct ttg cat gag gat tca aca acc cct gtg gct        295
Tyr Asp Lys Val Leu Ser Leu His Glu Asp Ser Thr Thr Pro Val Ala           
    70                  75                  80                            

aac cct ctg ctt gca ttt act ctc atc aaa cgc ctg cag tct gac tgg        343
Asn Pro Leu Leu Ala Phe Thr Leu Ile Lys Arg Leu Gln Ser Asp Trp           
85                  90                  95                  100           

agg aat gtg gta cat agt ctg gag gcc agt gag aac atc cga gct ctg        391
Arg Asn Val Val His Ser Leu Glu Ala Ser Glu Asn Ile Arg Ala Leu           
                105                 110                 115               

aag gat ggc tat gag aag gtg gag caa gac ctt cca gcc ttt gag gac        439
Lys Asp Gly Tyr Glu Lys Val Glu Gln Asp Leu Pro Ala Phe Glu Asp           
            120                 125                 130                   

ctt gag gga gca gca agg gcc ctg atg cgg ctg cag gac gtg tac atg        487
Leu Glu Gly Ala Ala Arg Ala Leu Met Arg Leu Gln Asp Val Tyr Met           
        135                 140                 145                       

ctc aat gtg aaa ggc ctg gcc cga ggt gtc ttt cag aga gtc act ggc        535
Leu Asn Val Lys Gly Leu Ala Arg Gly Val Phe Gln Arg Val Thr Gly           
    150                 155                 160                           

tct gcc atc act gac ctg tac agc ccc aaa cgg ctc ttt tct ctc aca        583
Ser Ala Ile Thr Asp Leu Tyr Ser Pro Lys Arg Leu Phe Ser Leu Thr           
165                 170                 175                 180           

ggg gat gac tgc ttc caa gtt ggc aag gtg gcc tat gac atg ggg gat        631
Gly Asp Asp Cys Phe Gln Val Gly Lys Val Ala Tyr Asp Met Gly Asp           
                185                 190                 195               

tat tac cat gcc att cca tgg ctg gag gag gct gtc agt ctc ttc cga        679
Tyr Tyr His Ala Ile Pro Trp Leu Glu Glu Ala Val Ser Leu Phe Arg           
            200                 205                 210                   

gga tct tac gga gag tgg aag aca gag gat gag gca agt cta gaa gat        727
Gly Ser Tyr Gly Glu Trp Lys Thr Glu Asp Glu Ala Ser Leu Glu Asp           
        215                 220                 225                       

gcc ttg gat cac ttg gcc ttt gct tat ttc cgg gca gga aat gtt tcg        775
Ala Leu Asp His Leu Ala Phe Ala Tyr Phe Arg Ala Gly Asn Val Ser           
    230                 235                 240                           

tgt gcc ctc agc ctc tct cgg gag ttt ctt ctc tac agc cca gat aat        823
Cys Ala Leu Ser Leu Ser Arg Glu Phe Leu Leu Tyr Ser Pro Asp Asn           
245                 250                 255                 260           

aag agg atg gcc agg aat gtc ttg aaa tat gaa agg ctc ttg gca gag        871
Lys Arg Met Ala Arg Asn Val Leu Lys Tyr Glu Arg Leu Leu Ala Glu           
                265                 270                 275               

agc ccc aac cac gtg gta gct gag gct gtc atc cag agg ccc aat ata        919
Ser Pro Asn His Val Val Ala Glu Ala Val Ile Gln Arg Pro Asn Ile           
            280                 285                 290                   

ccc cac ctg cag acc aga gac acc tac gag ggg cta tgt cag acc ctg        967
Pro His Leu Gln Thr Arg Asp Thr Tyr Glu Gly Leu Cys Gln Thr Leu           
        295                 300                 305                       

ggt tcc cag ccc act ctc tac cag atc cct agc ctc tac tgt tcc tat       1015
Gly Ser Gln Pro Thr Leu Tyr Gln Ile Pro Ser Leu Tyr Cys Ser Tyr           
    310                 315                 320                           

gag acc aat tcc aac gcc tac ctg ctg ctc cag ccc atc cgg aag gag       1063
Glu Thr Asn Ser Asn Ala Tyr Leu Leu Leu Gln Pro Ile Arg Lys Glu           
325                 330                 335                 340           

gtc atc cac ctg gag ccc tac att gct ctc tac cat gac ttc gtc agt       1111
Val Ile His Leu Glu Pro Tyr Ile Ala Leu Tyr His Asp Phe Val Ser           
                345                 350                 355               

gac tca gag gct cag aaa att aga gaa ctt gca gaa cca tgg cta cag       1159
Asp Ser Glu Ala Gln Lys Ile Arg Glu Leu Ala Glu Pro Trp Leu Gln           
            360                 365                 370                   

agg tca gtg gtg gca tca ggg gag aag cag tta caa gtg gag tac cgc       1207
Arg Ser Val Val Ala Ser Gly Glu Lys Gln Leu Gln Val Glu Tyr Arg           
        375                 380                 385                       

atc agc aaa agt gcc tgg ctg aag gac act gtt gac cca aaa ctg gtg       1255
Ile Ser Lys Ser Ala Trp Leu Lys Asp Thr Val Asp Pro Lys Leu Val           
    390                 395                 400                           

acc ctc aac cac cgc att gct gcc ctc aca ggc ctt gat gtc cgg cct       1303
Thr Leu Asn His Arg Ile Ala Ala Leu Thr Gly Leu Asp Val Arg Pro           
405                 410                 415                 420           

ccc tat gca gag tat ctg cag gtg gtg aac tat ggc atc gga gga cac       1351
Pro Tyr Ala Glu Tyr Leu Gln Val Val Asn Tyr Gly Ile Gly Gly His           
                425                 430                 435               

tat gag cct cac ttt gac cat gct acg tca cca agc agc ccc ctc tac       1399
Tyr Glu Pro His Phe Asp His Ala Thr Ser Pro Ser Ser Pro Leu Tyr           
            440                 445                 450                   

aga atg aag tca gga aac cga gtt gca aca ttt atg atc tat ctg agc       1447
Arg Met Lys Ser Gly Asn Arg Val Ala Thr Phe Met Ile Tyr Leu Ser           
        455                 460                 465                       

tcg gtg gaa gct gga gga gcc aca gcc ttc atc tat gcc aac ctc agc       1495
Ser Val Glu Ala Gly Gly Ala Thr Ala Phe Ile Tyr Ala Asn Leu Ser           
    470                 475                 480                           

gtg cct gtg gtt agg aat gca gca ctg ttt tgg tgg aac ctg cac agg       1543
Val Pro Val Val Arg Asn Ala Ala Leu Phe Trp Trp Asn Leu His Arg           
485                 490                 495                 500           

agt ggt gaa ggg gac agt gac aca ctt cat gct ggc tgt cct gtc ctg       1591
Ser Gly Glu Gly Asp Ser Asp Thr Leu His Ala Gly Cys Pro Val Leu           
                505                 510                 515               

gtg gga gat aag tgg gtg gcc aac aag tgg ata cat gag tat gga cag       1639
Val Gly Asp Lys Trp Val Ala Asn Lys Trp Ile His Glu Tyr Gly Gln           
            520                 525                 530                   

gaa ttc cgc aga ccc tgc agc tcc agc cct gaa gac tga actgttggca        1688
Glu Phe Arg Arg Pro Cys Ser Ser Ser Pro Glu Asp                           
        535                 540                                           

gagagaagct ggtggagtcc tgtggctttc cagagaagcc aggagccaaa agctggggta     1748

ggagaggaga aagcagagca gcctcctgga agaaggcctt gtcagctttg tctgtgcctc     1808

gcaaatcaga ggcaagggag aggttgttac caggggacac tgagaatgta catttgatct     1868

gccccagcca cggaagtcag agtaggatgc acagtacaaa ggagggggga gtggaggcct     1928

gagagggaag tttctggagt tcagatactc tctgttggga acaggacatc tcaacagtct     1988

caggttcgat cagtgggtct tttggcactt tgaaccttga ccacagggac caagaagtgg     2048

caatgaggac acctgcagga ggggctagcc tgactcccag aactttaaga ctttctcccc     2108

actgccttct gctgcagccc aagcagggag tgtccccctc ccagaagcat atcccagatg     2168

agtggtacat tatataagga ttttttttaa gttgaaaaca actttctttt ctttttgtat     2228

gatggttttt taacacagtc attaaaaatg tttataaatc aaaa                      2272


<210>  40
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gly Pro Gly Ala Arg Leu Ala Ala Leu Leu Ala Val Leu Ala Leu 
1               5                   10                  15      


Gly Thr Gly Asp Pro Glu Arg Ala Ala Ala Arg Gly Asp Thr Phe Ser 
            20                  25                  30          


Ala Leu Thr Ser Val Ala Arg Ala Leu Ala Pro Glu Arg Arg Leu Leu 
        35                  40                  45              


Gly Leu Leu Arg Arg Tyr Leu Arg Gly Glu Glu Ala Arg Leu Arg Asp 
    50                  55                  60                  


Leu Thr Arg Phe Tyr Asp Lys Val Leu Ser Leu His Glu Asp Ser Thr 
65                  70                  75                  80  


Thr Pro Val Ala Asn Pro Leu Leu Ala Phe Thr Leu Ile Lys Arg Leu 
                85                  90                  95      


Gln Ser Asp Trp Arg Asn Val Val His Ser Leu Glu Ala Ser Glu Asn 
            100                 105                 110         


Ile Arg Ala Leu Lys Asp Gly Tyr Glu Lys Val Glu Gln Asp Leu Pro 
        115                 120                 125             


Ala Phe Glu Asp Leu Glu Gly Ala Ala Arg Ala Leu Met Arg Leu Gln 
    130                 135                 140                 


Asp Val Tyr Met Leu Asn Val Lys Gly Leu Ala Arg Gly Val Phe Gln 
145                 150                 155                 160 


Arg Val Thr Gly Ser Ala Ile Thr Asp Leu Tyr Ser Pro Lys Arg Leu 
                165                 170                 175     


Phe Ser Leu Thr Gly Asp Asp Cys Phe Gln Val Gly Lys Val Ala Tyr 
            180                 185                 190         


Asp Met Gly Asp Tyr Tyr His Ala Ile Pro Trp Leu Glu Glu Ala Val 
        195                 200                 205             


Ser Leu Phe Arg Gly Ser Tyr Gly Glu Trp Lys Thr Glu Asp Glu Ala 
    210                 215                 220                 


Ser Leu Glu Asp Ala Leu Asp His Leu Ala Phe Ala Tyr Phe Arg Ala 
225                 230                 235                 240 


Gly Asn Val Ser Cys Ala Leu Ser Leu Ser Arg Glu Phe Leu Leu Tyr 
                245                 250                 255     


Ser Pro Asp Asn Lys Arg Met Ala Arg Asn Val Leu Lys Tyr Glu Arg 
            260                 265                 270         


Leu Leu Ala Glu Ser Pro Asn His Val Val Ala Glu Ala Val Ile Gln 
        275                 280                 285             


Arg Pro Asn Ile Pro His Leu Gln Thr Arg Asp Thr Tyr Glu Gly Leu 
    290                 295                 300                 


Cys Gln Thr Leu Gly Ser Gln Pro Thr Leu Tyr Gln Ile Pro Ser Leu 
305                 310                 315                 320 


Tyr Cys Ser Tyr Glu Thr Asn Ser Asn Ala Tyr Leu Leu Leu Gln Pro 
                325                 330                 335     


Ile Arg Lys Glu Val Ile His Leu Glu Pro Tyr Ile Ala Leu Tyr His 
            340                 345                 350         


Asp Phe Val Ser Asp Ser Glu Ala Gln Lys Ile Arg Glu Leu Ala Glu 
        355                 360                 365             


Pro Trp Leu Gln Arg Ser Val Val Ala Ser Gly Glu Lys Gln Leu Gln 
    370                 375                 380                 


Val Glu Tyr Arg Ile Ser Lys Ser Ala Trp Leu Lys Asp Thr Val Asp 
385                 390                 395                 400 


Pro Lys Leu Val Thr Leu Asn His Arg Ile Ala Ala Leu Thr Gly Leu 
                405                 410                 415     


Asp Val Arg Pro Pro Tyr Ala Glu Tyr Leu Gln Val Val Asn Tyr Gly 
            420                 425                 430         


Ile Gly Gly His Tyr Glu Pro His Phe Asp His Ala Thr Ser Pro Ser 
        435                 440                 445             


Ser Pro Leu Tyr Arg Met Lys Ser Gly Asn Arg Val Ala Thr Phe Met 
    450                 455                 460                 


Ile Tyr Leu Ser Ser Val Glu Ala Gly Gly Ala Thr Ala Phe Ile Tyr 
465                 470                 475                 480 


Ala Asn Leu Ser Val Pro Val Val Arg Asn Ala Ala Leu Phe Trp Trp 
                485                 490                 495     


Asn Leu His Arg Ser Gly Glu Gly Asp Ser Asp Thr Leu His Ala Gly 
            500                 505                 510         


Cys Pro Val Leu Val Gly Asp Lys Trp Val Ala Asn Lys Trp Ile His 
        515                 520                 525             


Glu Tyr Gly Gln Glu Phe Arg Arg Pro Cys Ser Ser Ser Pro Glu Asp 
    530                 535                 540                 


<210>  41
<211>  8588
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (481)..(7953)

<400>  41
gagtagctcc agcggccacg ctgaggcgag ggtgacacac catgctcacg gcccctggag       60

accgtcgtgc tggcgagccg tgctccgtag ctccccggtc cgcctcggca gcggtcagag      120

tcgcctacag gagttgagcc gcccgcgcca gaaggttttg gcgaagctct tggagaggcg      180

tcgagcacag tagggcggcg ggggtgcgtt gagcgctcgg gggtcaggca gtcggccggg      240

atcgccgctg gggagcgttt ccgaggcgag gaggaggagg aggagatgct gctcctcttc      300

tccccctccc caggctcctt ctacagctcc ttcagcccac gcccgcagcc gcttgtggga      360

gaagtggtgg tggctctcgg cgcccgcggc ggctgccggc ggcccgcccc gacgccgcgt      420

ccctgcagcc ctcgcccggc gctccagtag caggacccgg tctcgggacc agccggtaat      480

atg cac gtg tca cta gct gag gcc ctg gag gtt cgg ggt gga cca ctt        528
Met His Val Ser Leu Ala Glu Ala Leu Glu Val Arg Gly Gly Pro Leu           
1               5                   10                  15                

cag gag gaa gaa ata tgg gct gta tta aat caa agt gct gaa agt ctc        576
Gln Glu Glu Glu Ile Trp Ala Val Leu Asn Gln Ser Ala Glu Ser Leu           
            20                  25                  30                    

caa gaa tta ttc aga aaa gta agc cta gct gat cct gct gcc ctt ggc        624
Gln Glu Leu Phe Arg Lys Val Ser Leu Ala Asp Pro Ala Ala Leu Gly           
        35                  40                  45                        

ttc atc att tct cca tgg tct ctg ctg ttg ctg cca tct ggt agt gtg        672
Phe Ile Ile Ser Pro Trp Ser Leu Leu Leu Leu Pro Ser Gly Ser Val           
    50                  55                  60                            

tca ttt aca gat gaa aat att tcc aat cag gat ctt cga gca ttc act        720
Ser Phe Thr Asp Glu Asn Ile Ser Asn Gln Asp Leu Arg Ala Phe Thr           
65                  70                  75                  80            

gca cca gag gtt ctt caa aat cag tca cta act tct ctc tca gat gtt        768
Ala Pro Glu Val Leu Gln Asn Gln Ser Leu Thr Ser Leu Ser Asp Val           
                85                  90                  95                

gaa aag atc cac att tat tct ctt gga atg aca ctg tat tgg ggg gct        816
Glu Lys Ile His Ile Tyr Ser Leu Gly Met Thr Leu Tyr Trp Gly Ala           
            100                 105                 110                   

gat tat gaa gtg cct cag agc caa cct att aag ctt gga gat cat ctc        864
Asp Tyr Glu Val Pro Gln Ser Gln Pro Ile Lys Leu Gly Asp His Leu           
        115                 120                 125                       

aac agc ata ctg ctt gga atg tgt gag gat gtt att tac gct cga gtt        912
Asn Ser Ile Leu Leu Gly Met Cys Glu Asp Val Ile Tyr Ala Arg Val           
    130                 135                 140                           

tct gtt cgg act gtg ctg gat gct tgc agt gcc cac att agg aat agc        960
Ser Val Arg Thr Val Leu Asp Ala Cys Ser Ala His Ile Arg Asn Ser           
145                 150                 155                 160           

aat tgt gca ccc tca ttt tcc tac gtg aaa cac ttg gta aaa ctg gtt       1008
Asn Cys Ala Pro Ser Phe Ser Tyr Val Lys His Leu Val Lys Leu Val           
                165                 170                 175               

ctg gga aat ctt tct ggg aca gat cag ctt tcc tgt aac agt gaa caa       1056
Leu Gly Asn Leu Ser Gly Thr Asp Gln Leu Ser Cys Asn Ser Glu Gln           
            180                 185                 190                   

aag cct gat cga agc cag gct att cga gat cga ttg cga gga aaa gga       1104
Lys Pro Asp Arg Ser Gln Ala Ile Arg Asp Arg Leu Arg Gly Lys Gly           
        195                 200                 205                       

tta cca aca gga aga agc tct act tct gat gta cta gac ata caa aag       1152
Leu Pro Thr Gly Arg Ser Ser Thr Ser Asp Val Leu Asp Ile Gln Lys           
    210                 215                 220                           

cct cca ctc tct cat cag acc ttt ctt aac aaa ggg ctt agt aaa tct       1200
Pro Pro Leu Ser His Gln Thr Phe Leu Asn Lys Gly Leu Ser Lys Ser           
225                 230                 235                 240           

atg gga ttt ctg tcc atc aaa gat aca caa gat gag aat tat ttc aag       1248
Met Gly Phe Leu Ser Ile Lys Asp Thr Gln Asp Glu Asn Tyr Phe Lys           
                245                 250                 255               

gac att tta tca gat aat tct gga cgt gaa gat tct gaa aat aca ttc       1296
Asp Ile Leu Ser Asp Asn Ser Gly Arg Glu Asp Ser Glu Asn Thr Phe           
            260                 265                 270                   

tcc cct tac cag ttc aaa act agt ggc cca gaa aaa aaa ccc atc cct       1344
Ser Pro Tyr Gln Phe Lys Thr Ser Gly Pro Glu Lys Lys Pro Ile Pro           
        275                 280                 285                       

ggc att gat gtg ctt tct aag aag aag atc tgg gct tca tcc atg gac       1392
Gly Ile Asp Val Leu Ser Lys Lys Lys Ile Trp Ala Ser Ser Met Asp           
    290                 295                 300                           

ttg ctt tgt aca gct gac aga gac ttc tct tca gga gag act gcc aca       1440
Leu Leu Cys Thr Ala Asp Arg Asp Phe Ser Ser Gly Glu Thr Ala Thr           
305                 310                 315                 320           

tat cgt cgt tgt cac cct gag gca gta aca gtg cgg act tca act act       1488
Tyr Arg Arg Cys His Pro Glu Ala Val Thr Val Arg Thr Ser Thr Thr           
                325                 330                 335               

cct aga aaa aag gag gca aga tac tca gat gga agt ata gcc ttg gat       1536
Pro Arg Lys Lys Glu Ala Arg Tyr Ser Asp Gly Ser Ile Ala Leu Asp           
            340                 345                 350                   

atc ttt ggc cct cag aaa atg gat cca ata tat cac act cga gaa ttg       1584
Ile Phe Gly Pro Gln Lys Met Asp Pro Ile Tyr His Thr Arg Glu Leu           
        355                 360                 365                       

ccc acc tcc tca gca ata tca agt gct ttg gac cga atc cga gag aga       1632
Pro Thr Ser Ser Ala Ile Ser Ser Ala Leu Asp Arg Ile Arg Glu Arg           
    370                 375                 380                           

caa aag aaa ctt cag gtt ctg agg gaa gcc atg aat gta gaa gaa cca       1680
Gln Lys Lys Leu Gln Val Leu Arg Glu Ala Met Asn Val Glu Glu Pro           
385                 390                 395                 400           

gtt cga aga tac aaa act tat cat ggt gat gtc ttt agt acc tcc agt       1728
Val Arg Arg Tyr Lys Thr Tyr His Gly Asp Val Phe Ser Thr Ser Ser           
                405                 410                 415               

gaa agt cca tct att att tcc tct gaa tca gat ttc aga caa gtg aga       1776
Glu Ser Pro Ser Ile Ile Ser Ser Glu Ser Asp Phe Arg Gln Val Arg           
            420                 425                 430                   

aga agt gaa gcc tca aag agg ttt gaa tcc agc agt ggt ctc cca ggg       1824
Arg Ser Glu Ala Ser Lys Arg Phe Glu Ser Ser Ser Gly Leu Pro Gly           
        435                 440                 445                       

gta gat gaa acc tta agt caa ggc cag tca cag aga ccg agc aga caa       1872
Val Asp Glu Thr Leu Ser Gln Gly Gln Ser Gln Arg Pro Ser Arg Gln           
    450                 455                 460                           

tat gaa aca ccc ttt gaa ggc aac tta att aat caa gag atc atg cta       1920
Tyr Glu Thr Pro Phe Glu Gly Asn Leu Ile Asn Gln Glu Ile Met Leu           
465                 470                 475                 480           

aaa cgg caa gag gaa gaa ctg atg cag cta caa gcc aaa atg gcc ctt       1968
Lys Arg Gln Glu Glu Glu Leu Met Gln Leu Gln Ala Lys Met Ala Leu           
                485                 490                 495               

aga cag tct cgg ttg agc cta tat cca gga gac aca atc aaa gcg tcc       2016
Arg Gln Ser Arg Leu Ser Leu Tyr Pro Gly Asp Thr Ile Lys Ala Ser           
            500                 505                 510                   

atg ctt gac atc acc agg gat ccg tta aga gaa att gcc cta gaa aca       2064
Met Leu Asp Ile Thr Arg Asp Pro Leu Arg Glu Ile Ala Leu Glu Thr           
        515                 520                 525                       

gcc atg act caa aga aaa ctg agg aat ttc ttt ggc cct gag ttt gtg       2112
Ala Met Thr Gln Arg Lys Leu Arg Asn Phe Phe Gly Pro Glu Phe Val           
    530                 535                 540                           

aaa atg aca att gaa cca ttt ata tct ttg gat ttg cca cgg tct att       2160
Lys Met Thr Ile Glu Pro Phe Ile Ser Leu Asp Leu Pro Arg Ser Ile           
545                 550                 555                 560           

ctt act aag aaa ggg aag aat gag gat aac cga agg aaa gta aac ata       2208
Leu Thr Lys Lys Gly Lys Asn Glu Asp Asn Arg Arg Lys Val Asn Ile           
                565                 570                 575               

atg ctt ctg aac ggg caa aga ctg gaa ctg acc tgt gat acc aaa act       2256
Met Leu Leu Asn Gly Gln Arg Leu Glu Leu Thr Cys Asp Thr Lys Thr           
            580                 585                 590                   

ata tgt aaa gat gtg ttt gat atg gtt gtg gca cat att ggc tta gta       2304
Ile Cys Lys Asp Val Phe Asp Met Val Val Ala His Ile Gly Leu Val           
        595                 600                 605                       

gag cat cat ttg ttt gct tta gct acc ctc aaa gat aat gaa tat ttc       2352
Glu His His Leu Phe Ala Leu Ala Thr Leu Lys Asp Asn Glu Tyr Phe           
    610                 615                 620                           

ttt gtt gat cct gac tta aaa tta acc aaa gtg gcc cca gag gga tgg       2400
Phe Val Asp Pro Asp Leu Lys Leu Thr Lys Val Ala Pro Glu Gly Trp           
625                 630                 635                 640           

aaa gaa gaa cca aag aaa aag acc aaa gcc act gtt aat ttt act ttg       2448
Lys Glu Glu Pro Lys Lys Lys Thr Lys Ala Thr Val Asn Phe Thr Leu           
                645                 650                 655               

ttt ttc aga att aaa ttt ttt atg gat gat gtt agt cta ata caa cat       2496
Phe Phe Arg Ile Lys Phe Phe Met Asp Asp Val Ser Leu Ile Gln His           
            660                 665                 670                   

act ctg acg tgt cat cag tat tac ctt cag ctt cga aaa gat att ttg       2544
Thr Leu Thr Cys His Gln Tyr Tyr Leu Gln Leu Arg Lys Asp Ile Leu           
        675                 680                 685                       

gag gaa agg atg cac tgt gat gat gag act tcc tta ttg ctg gca tcc       2592
Glu Glu Arg Met His Cys Asp Asp Glu Thr Ser Leu Leu Leu Ala Ser           
    690                 695                 700                           

ttg gct ctc cag gct gag tat gga gat tat caa cca gag gtt cat ggt       2640
Leu Ala Leu Gln Ala Glu Tyr Gly Asp Tyr Gln Pro Glu Val His Gly           
705                 710                 715                 720           

gtg tct tac ttt aga atg gag cac tat ttg ccc gcc aga gtg atg gag       2688
Val Ser Tyr Phe Arg Met Glu His Tyr Leu Pro Ala Arg Val Met Glu           
                725                 730                 735               

aaa ctt gat tta tcc tat atc aaa gaa gag tta ccc aaa ttg cat aat       2736
Lys Leu Asp Leu Ser Tyr Ile Lys Glu Glu Leu Pro Lys Leu His Asn           
            740                 745                 750                   

acc tat gtg gga gct tct gaa aaa gag aca gag tta gaa ttt tta aag       2784
Thr Tyr Val Gly Ala Ser Glu Lys Glu Thr Glu Leu Glu Phe Leu Lys           
        755                 760                 765                       

gtc tgc caa aga ctg aca gaa tat gga gtt cat ttt cac cga gtg cac       2832
Val Cys Gln Arg Leu Thr Glu Tyr Gly Val His Phe His Arg Val His           
    770                 775                 780                           

cct gag aag aag tca caa aca gga ata ttg ctt gga gtc tgt tct aaa       2880
Pro Glu Lys Lys Ser Gln Thr Gly Ile Leu Leu Gly Val Cys Ser Lys           
785                 790                 795                 800           

ggt gtc ctt gtg ttt gaa gtt cac aat gga gtg cgc aca ttg gtc ctt       2928
Gly Val Leu Val Phe Glu Val His Asn Gly Val Arg Thr Leu Val Leu           
                805                 810                 815               

cgc ttt cca tgg agg gaa acc aag aaa ata tct ttt tct aaa aag aaa       2976
Arg Phe Pro Trp Arg Glu Thr Lys Lys Ile Ser Phe Ser Lys Lys Lys           
            820                 825                 830                   

atc aca ttg caa aat aca tca gat gga ata aaa cat ggc ttc cag aca       3024
Ile Thr Leu Gln Asn Thr Ser Asp Gly Ile Lys His Gly Phe Gln Thr           
        835                 840                 845                       

gac aac agt aag ata tgc cag tac ctg ctg cac ctc tgc tct tac cag       3072
Asp Asn Ser Lys Ile Cys Gln Tyr Leu Leu His Leu Cys Ser Tyr Gln           
    850                 855                 860                           

cat aag ttc cag cta cag atg aga gca aga cag agc aac caa gat gcc       3120
His Lys Phe Gln Leu Gln Met Arg Ala Arg Gln Ser Asn Gln Asp Ala           
865                 870                 875                 880           

caa gat att gag aga gct tcg ttt agg agc ctg aat ctc caa gca gag       3168
Gln Asp Ile Glu Arg Ala Ser Phe Arg Ser Leu Asn Leu Gln Ala Glu           
                885                 890                 895               

tct gtt aga gga ttt aat atg gga cga gca atc agc act ggc agt ctg       3216
Ser Val Arg Gly Phe Asn Met Gly Arg Ala Ile Ser Thr Gly Ser Leu           
            900                 905                 910                   

gcc agc agc acc ctc aac aaa ctt gct gtt cga cct tta tca gtt caa       3264
Ala Ser Ser Thr Leu Asn Lys Leu Ala Val Arg Pro Leu Ser Val Gln           
        915                 920                 925                       

gct gag att ctg aag agg cta tcc tgc tca gag ctg tcg ctt tac cag       3312
Ala Glu Ile Leu Lys Arg Leu Ser Cys Ser Glu Leu Ser Leu Tyr Gln           
    930                 935                 940                           

cca ttg caa aac agt tca aaa gag aag aat gac aaa gct tca tgg gag       3360
Pro Leu Gln Asn Ser Ser Lys Glu Lys Asn Asp Lys Ala Ser Trp Glu           
945                 950                 955                 960           

gaa aag cct aga gag atg agt aaa tca tac cat gat ctc agt cag gcc       3408
Glu Lys Pro Arg Glu Met Ser Lys Ser Tyr His Asp Leu Ser Gln Ala           
                965                 970                 975               

tct ctc tat cca cat cgg aaa aat gtc att gtt aac atg gaa ccc cca       3456
Ser Leu Tyr Pro His Arg Lys Asn Val Ile Val Asn Met Glu Pro Pro           
            980                 985                 990                   

cca caa acc gtt gca gag ttg gtg  gga aaa cct tct cac  cag atg tca     3504
Pro Gln Thr Val Ala Glu Leu Val  Gly Lys Pro Ser His  Gln Met Ser         
        995                 1000                 1005                     

aga tct  gat gca gaa tct ttg  gca gga gtg aca aaa  ctt aat aat        3549
Arg Ser  Asp Ala Glu Ser Leu  Ala Gly Val Thr Lys  Leu Asn Asn            
    1010                 1015                 1020                        

tca aag  tct gtt gcg agt tta  aat aga agt cct gaa  agg agg aaa        3594
Ser Lys  Ser Val Ala Ser Leu  Asn Arg Ser Pro Glu  Arg Arg Lys            
    1025                 1030                 1035                        

cat gaa  tca gac tcc tca tcc  att gaa gac cct ggg  caa gca tat        3639
His Glu  Ser Asp Ser Ser Ser  Ile Glu Asp Pro Gly  Gln Ala Tyr            
    1040                 1045                 1050                        

gtt cta  gga atg act atg cat  agt tct gga aac tct  tca tcc caa        3684
Val Leu  Gly Met Thr Met His  Ser Ser Gly Asn Ser  Ser Ser Gln            
    1055                 1060                 1065                        

gta ccc  tta aaa gaa aat gat  gtg cta cac aaa aga  tgg agc ata        3729
Val Pro  Leu Lys Glu Asn Asp  Val Leu His Lys Arg  Trp Ser Ile            
    1070                 1075                 1080                        

gta tct  tca cca gaa agg gag  atc acc tta gtg aac  ctg aaa aaa        3774
Val Ser  Ser Pro Glu Arg Glu  Ile Thr Leu Val Asn  Leu Lys Lys            
    1085                 1090                 1095                        

gat gca  aag tat ggc ttg gga  ttt caa att att ggt  ggg gag aag        3819
Asp Ala  Lys Tyr Gly Leu Gly  Phe Gln Ile Ile Gly  Gly Glu Lys            
    1100                 1105                 1110                        

atg gga  aga ctg gac cta ggc  ata ttt atc agt tca  gtt gcc cct        3864
Met Gly  Arg Leu Asp Leu Gly  Ile Phe Ile Ser Ser  Val Ala Pro            
    1115                 1120                 1125                        

gga gga  cca gct gac ttg gat  gga tgc ttg aag cca  gga gac cgt        3909
Gly Gly  Pro Ala Asp Leu Asp  Gly Cys Leu Lys Pro  Gly Asp Arg            
    1130                 1135                 1140                        

ttg ata  tct gtg aat agt gtg  agt ctg gag gga gtc  agc cac cat        3954
Leu Ile  Ser Val Asn Ser Val  Ser Leu Glu Gly Val  Ser His His            
    1145                 1150                 1155                        

gct gca  att gaa att ttg caa  aat gca cct gaa gat  gtg aca ctt        3999
Ala Ala  Ile Glu Ile Leu Gln  Asn Ala Pro Glu Asp  Val Thr Leu            
    1160                 1165                 1170                        

gtt atc  tct cag cca aaa gaa  aag ata tcc aaa gtg  cct tct act        4044
Val Ile  Ser Gln Pro Lys Glu  Lys Ile Ser Lys Val  Pro Ser Thr            
    1175                 1180                 1185                        

cct gtg  cat ctc acc aat gag  atg aaa aac tac atg  aag aaa tct        4089
Pro Val  His Leu Thr Asn Glu  Met Lys Asn Tyr Met  Lys Lys Ser            
    1190                 1195                 1200                        

tcc tac  atg caa gac agt gct  ata gat tct tct tcc  aag gat cac        4134
Ser Tyr  Met Gln Asp Ser Ala  Ile Asp Ser Ser Ser  Lys Asp His            
    1205                 1210                 1215                        

cac tgg  tca cgt ggt acc ctg  agg cac atc tcg gag  aac tcc ttt        4179
His Trp  Ser Arg Gly Thr Leu  Arg His Ile Ser Glu  Asn Ser Phe            
    1220                 1225                 1230                        

ggg cca  tct ggg ggc ctg cgg  gaa gga agc ctg agt  tct caa gat        4224
Gly Pro  Ser Gly Gly Leu Arg  Glu Gly Ser Leu Ser  Ser Gln Asp            
    1235                 1240                 1245                        

tcc agg  act gag agt gcc agc  ttg tct caa agc cag  gtc aat ggt        4269
Ser Arg  Thr Glu Ser Ala Ser  Leu Ser Gln Ser Gln  Val Asn Gly            
    1250                 1255                 1260                        

ttc ttt  gcc agc cat tta ggt  gac caa acc tgg cag  gaa tca cag        4314
Phe Phe  Ala Ser His Leu Gly  Asp Gln Thr Trp Gln  Glu Ser Gln            
    1265                 1270                 1275                        

cat ggc  agc cct tcc cca tct  gta ata tcc aaa gcc  acc gag aaa        4359
His Gly  Ser Pro Ser Pro Ser  Val Ile Ser Lys Ala  Thr Glu Lys            
    1280                 1285                 1290                        

gag act  ttc act gat agt aac  caa agc aaa act aaa  aag cca ggc        4404
Glu Thr  Phe Thr Asp Ser Asn  Gln Ser Lys Thr Lys  Lys Pro Gly            
    1295                 1300                 1305                        

att tct  gat gta act gat tac  tca gac cgt gga gat  tca gac atg        4449
Ile Ser  Asp Val Thr Asp Tyr  Ser Asp Arg Gly Asp  Ser Asp Met            
    1310                 1315                 1320                        

gat gaa  gcc act tac tcc agc  agt cag gat cat caa  aca cca aaa        4494
Asp Glu  Ala Thr Tyr Ser Ser  Ser Gln Asp His Gln  Thr Pro Lys            
    1325                 1330                 1335                        

cag gaa  tct tcc tct tca gtg  aat aca tcc aac aag  atg aat ttt        4539
Gln Glu  Ser Ser Ser Ser Val  Asn Thr Ser Asn Lys  Met Asn Phe            
    1340                 1345                 1350                        

aaa act  ttt tct tca tca cct  cct aag cct gga gat  atc ttt gag        4584
Lys Thr  Phe Ser Ser Ser Pro  Pro Lys Pro Gly Asp  Ile Phe Glu            
    1355                 1360                 1365                        

gtt gaa  ctg gct aaa aat gat  aac agc ttg ggg ata  agt gtc acg        4629
Val Glu  Leu Ala Lys Asn Asp  Asn Ser Leu Gly Ile  Ser Val Thr            
    1370                 1375                 1380                        

gta ctg  ttt gac aag gga ggt  gtg aat acg agt gtc  aga cat ggt        4674
Val Leu  Phe Asp Lys Gly Gly  Val Asn Thr Ser Val  Arg His Gly            
    1385                 1390                 1395                        

ggc att  tat gtg aaa gct gtt  att ccc cag gga gca  gca gag tct        4719
Gly Ile  Tyr Val Lys Ala Val  Ile Pro Gln Gly Ala  Ala Glu Ser            
    1400                 1405                 1410                        

gat ggt  aga att cac aaa ggt  gat cgc gtc cta gct  gtc aat gga        4764
Asp Gly  Arg Ile His Lys Gly  Asp Arg Val Leu Ala  Val Asn Gly            
    1415                 1420                 1425                        

gtt agt  cta gaa gga gcc acc  cat aag caa gct gtg  gaa aca ctg        4809
Val Ser  Leu Glu Gly Ala Thr  His Lys Gln Ala Val  Glu Thr Leu            
    1430                 1435                 1440                        

aga aat  aca gga cag gtg gtt  cat ctg tta tta gaa  aag gga caa        4854
Arg Asn  Thr Gly Gln Val Val  His Leu Leu Leu Glu  Lys Gly Gln            
    1445                 1450                 1455                        

tct cca  aca tct aaa gaa cat  gtc ccg gta acc cca  cag tgt acc        4899
Ser Pro  Thr Ser Lys Glu His  Val Pro Val Thr Pro  Gln Cys Thr            
    1460                 1465                 1470                        

ctt tca  gat cag aat gcc caa  ggt caa ggc cca gaa  aaa gtg aag        4944
Leu Ser  Asp Gln Asn Ala Gln  Gly Gln Gly Pro Glu  Lys Val Lys            
    1475                 1480                 1485                        

aaa aca  act cag gtc aaa gac  tac agc ttt gtc act  gaa gaa aat        4989
Lys Thr  Thr Gln Val Lys Asp  Tyr Ser Phe Val Thr  Glu Glu Asn            
    1490                 1495                 1500                        

aca ttt  gag gta aaa tta ttt  aaa aat agc tca ggt  cta gga ttc        5034
Thr Phe  Glu Val Lys Leu Phe  Lys Asn Ser Ser Gly  Leu Gly Phe            
    1505                 1510                 1515                        

agt ttt  tct cga gaa gat aat  ctt ata ccg gag caa  att aat gcc        5079
Ser Phe  Ser Arg Glu Asp Asn  Leu Ile Pro Glu Gln  Ile Asn Ala            
    1520                 1525                 1530                        

agc ata  gta agg gtt aaa aag  ctc ttt cct gga cag  cca gca gca        5124
Ser Ile  Val Arg Val Lys Lys  Leu Phe Pro Gly Gln  Pro Ala Ala            
    1535                 1540                 1545                        

gaa agt  gga aaa att gat gta  gga gat gtt atc ttg  aaa gtg aat        5169
Glu Ser  Gly Lys Ile Asp Val  Gly Asp Val Ile Leu  Lys Val Asn            
    1550                 1555                 1560                        

gga gcc  tct ttg aaa gga cta  tct cag cag gaa gtc  ata tct gct        5214
Gly Ala  Ser Leu Lys Gly Leu  Ser Gln Gln Glu Val  Ile Ser Ala            
    1565                 1570                 1575                        

ctc agg  gga act gct cca gaa  gta ttc ttg ctt ctc  tgc aga cct        5259
Leu Arg  Gly Thr Ala Pro Glu  Val Phe Leu Leu Leu  Cys Arg Pro            
    1580                 1585                 1590                        

cca cct  ggt gtg cta ccg gaa  att gat act gcg ctt  ttg acc cca        5304
Pro Pro  Gly Val Leu Pro Glu  Ile Asp Thr Ala Leu  Leu Thr Pro            
    1595                 1600                 1605                        

ctt cag  tct cca gca caa gta  ctt cca aac agc agt  aaa gac tct        5349
Leu Gln  Ser Pro Ala Gln Val  Leu Pro Asn Ser Ser  Lys Asp Ser            
    1610                 1615                 1620                        

tct cag  cca tca tgt gtg gag  caa agc acc agc tca  gat gaa aat        5394
Ser Gln  Pro Ser Cys Val Glu  Gln Ser Thr Ser Ser  Asp Glu Asn            
    1625                 1630                 1635                        

gaa atg  tca gac aaa agc aaa  aaa cag tgc aag tcc  cca tcc aga        5439
Glu Met  Ser Asp Lys Ser Lys  Lys Gln Cys Lys Ser  Pro Ser Arg            
    1640                 1645                 1650                        

aga gac  agt tac agt gac agc  agt ggg agt gga gaa  gat gac tta        5484
Arg Asp  Ser Tyr Ser Asp Ser  Ser Gly Ser Gly Glu  Asp Asp Leu            
    1655                 1660                 1665                        

gtg aca  gct cca gca aac ata  tca aat tcg acc tgg  agt tca gct        5529
Val Thr  Ala Pro Ala Asn Ile  Ser Asn Ser Thr Trp  Ser Ser Ala            
    1670                 1675                 1680                        

ttg cat  cag act cta agc aac  atg gta tca cag gca  cag agt cat        5574
Leu His  Gln Thr Leu Ser Asn  Met Val Ser Gln Ala  Gln Ser His            
    1685                 1690                 1695                        

cat gaa  gca ccc aag agt caa  gaa gat acc att tgt  acc atg ttt        5619
His Glu  Ala Pro Lys Ser Gln  Glu Asp Thr Ile Cys  Thr Met Phe            
    1700                 1705                 1710                        

tac tat  cct cag aaa att ccc  aat aaa cca gag ttt  gag gac agt        5664
Tyr Tyr  Pro Gln Lys Ile Pro  Asn Lys Pro Glu Phe  Glu Asp Ser            
    1715                 1720                 1725                        

aat cct  tcc cct cta cca ccg  gat atg gct cct ggg  cag agt tat        5709
Asn Pro  Ser Pro Leu Pro Pro  Asp Met Ala Pro Gly  Gln Ser Tyr            
    1730                 1735                 1740                        

caa ccc  caa tca gaa tct gct  tcc tct agt tcg atg  gat aag tat        5754
Gln Pro  Gln Ser Glu Ser Ala  Ser Ser Ser Ser Met  Asp Lys Tyr            
    1745                 1750                 1755                        

cat ata  cat cac att tct gaa  cca act aga caa gaa  aac tgg aca        5799
His Ile  His His Ile Ser Glu  Pro Thr Arg Gln Glu  Asn Trp Thr            
    1760                 1765                 1770                        

cct ttg  aaa aat gac ttg gaa  aat cac ctt gaa gac  ttt gaa ctg        5844
Pro Leu  Lys Asn Asp Leu Glu  Asn His Leu Glu Asp  Phe Glu Leu            
    1775                 1780                 1785                        

gaa gta  gaa ctc ctc att acc  cta att aaa tca gaa  aaa gga agc        5889
Glu Val  Glu Leu Leu Ile Thr  Leu Ile Lys Ser Glu  Lys Gly Ser            
    1790                 1795                 1800                        

ctg ggt  ttt aca gta acc aaa  ggc aat cag aga att  ggt tgt tat        5934
Leu Gly  Phe Thr Val Thr Lys  Gly Asn Gln Arg Ile  Gly Cys Tyr            
    1805                 1810                 1815                        

gtt cat  gat gtc ata cag gat  cca gcc aaa agt gat  gga agg cta        5979
Val His  Asp Val Ile Gln Asp  Pro Ala Lys Ser Asp  Gly Arg Leu            
    1820                 1825                 1830                        

aaa cct  ggg gac cgg ctc ata  aag gtt aat gat aca  gat gtt act        6024
Lys Pro  Gly Asp Arg Leu Ile  Lys Val Asn Asp Thr  Asp Val Thr            
    1835                 1840                 1845                        

aat atg  act cat aca gat gca  gtt aat ctg ctc cgg  gct gca tcc        6069
Asn Met  Thr His Thr Asp Ala  Val Asn Leu Leu Arg  Ala Ala Ser            
    1850                 1855                 1860                        

aaa aca  gtc aga tta gtt att  gga cga gtt cta gaa  tta ccc aga        6114
Lys Thr  Val Arg Leu Val Ile  Gly Arg Val Leu Glu  Leu Pro Arg            
    1865                 1870                 1875                        

ata cca  atg ttg cct cat ttg  cta ccg gac ata aca  cta acg tgc        6159
Ile Pro  Met Leu Pro His Leu  Leu Pro Asp Ile Thr  Leu Thr Cys            
    1880                 1885                 1890                        

aac aaa  gag gag ttg ggt ttt  tcc tta tgt gga ggt  cat gac agc        6204
Asn Lys  Glu Glu Leu Gly Phe  Ser Leu Cys Gly Gly  His Asp Ser            
    1895                 1900                 1905                        

ctt tat  caa gtg gta tat att  agt gat att aat cca  agg tcc gtc        6249
Leu Tyr  Gln Val Val Tyr Ile  Ser Asp Ile Asn Pro  Arg Ser Val            
    1910                 1915                 1920                        

gca gcc  att gag ggt aat ctc  cag cta tta gat gtc  atc cat tat        6294
Ala Ala  Ile Glu Gly Asn Leu  Gln Leu Leu Asp Val  Ile His Tyr            
    1925                 1930                 1935                        

gtg aac  gga gtc agc aca caa  gga atg acc ttg gag  gaa gtt aac        6339
Val Asn  Gly Val Ser Thr Gln  Gly Met Thr Leu Glu  Glu Val Asn            
    1940                 1945                 1950                        

aga gca  tta gac atg tca ctt  cct tca ttg gta ttg  aaa gca aca        6384
Arg Ala  Leu Asp Met Ser Leu  Pro Ser Leu Val Leu  Lys Ala Thr            
    1955                 1960                 1965                        

aga aat  gat ctt cca gtg gtc  ccc agc tca aag agg  tct gct gtt        6429
Arg Asn  Asp Leu Pro Val Val  Pro Ser Ser Lys Arg  Ser Ala Val            
    1970                 1975                 1980                        

tca gct  cca aag tca acc aaa  ggc aat ggt tcc tac  agt gtg ggg        6474
Ser Ala  Pro Lys Ser Thr Lys  Gly Asn Gly Ser Tyr  Ser Val Gly            
    1985                 1990                 1995                        

tct tgc  agc cag cct gcc ctc  act cct aat gat tca  ttc tcc acg        6519
Ser Cys  Ser Gln Pro Ala Leu  Thr Pro Asn Asp Ser  Phe Ser Thr            
    2000                 2005                 2010                        

gtt gct  ggg gaa gaa ata aat  gaa ata tcg tac ccc  aaa gga aaa        6564
Val Ala  Gly Glu Glu Ile Asn  Glu Ile Ser Tyr Pro  Lys Gly Lys            
    2015                 2020                 2025                        

tgt tct  act tat cag ata aag  gga tca cca aac ttg  act ctg ccc        6609
Cys Ser  Thr Tyr Gln Ile Lys  Gly Ser Pro Asn Leu  Thr Leu Pro            
    2030                 2035                 2040                        

aaa gaa  tct tat ata caa gaa  gat gac att tat gat  gat tcc caa        6654
Lys Glu  Ser Tyr Ile Gln Glu  Asp Asp Ile Tyr Asp  Asp Ser Gln            
    2045                 2050                 2055                        

gaa gct  gaa gtt atc cag tct  ctg ctg gat gtt gtg  gat gag gaa        6699
Glu Ala  Glu Val Ile Gln Ser  Leu Leu Asp Val Val  Asp Glu Glu            
    2060                 2065                 2070                        

gcc cag  aat ctt tta aac gaa  aat aat gca gca gga  tac tcc tgt        6744
Ala Gln  Asn Leu Leu Asn Glu  Asn Asn Ala Ala Gly  Tyr Ser Cys            
    2075                 2080                 2085                        

ggt cca  ggt aca tta aag atg  aat ggg aag tta tca  gaa gag aga        6789
Gly Pro  Gly Thr Leu Lys Met  Asn Gly Lys Leu Ser  Glu Glu Arg            
    2090                 2095                 2100                        

aca gaa  gat aca gac tgc gat  ggt tca cct tta cct  gag tat ttt        6834
Thr Glu  Asp Thr Asp Cys Asp  Gly Ser Pro Leu Pro  Glu Tyr Phe            
    2105                 2110                 2115                        

act gag  gcc acc aaa atg aat  ggc tgt gaa gaa tat  tgt gaa gaa        6879
Thr Glu  Ala Thr Lys Met Asn  Gly Cys Glu Glu Tyr  Cys Glu Glu            
    2120                 2125                 2130                        

aaa gta  aaa agt gaa agc tta  att cag aag cca caa  gaa aag aag        6924
Lys Val  Lys Ser Glu Ser Leu  Ile Gln Lys Pro Gln  Glu Lys Lys            
    2135                 2140                 2145                        

act gat  gat gat gaa ata aca  tgg gga aat gat gag  ttg cca ata        6969
Thr Asp  Asp Asp Glu Ile Thr  Trp Gly Asn Asp Glu  Leu Pro Ile            
    2150                 2155                 2160                        

gag aga  aca aac cat gaa gat  tct gat aaa gat cat  tcc ttt ctg        7014
Glu Arg  Thr Asn His Glu Asp  Ser Asp Lys Asp His  Ser Phe Leu            
    2165                 2170                 2175                        

aca aac  gat gag ctc gct gta  ctc cct gtc gtc aaa  gtg ctt ccc        7059
Thr Asn  Asp Glu Leu Ala Val  Leu Pro Val Val Lys  Val Leu Pro            
    2180                 2185                 2190                        

tct ggt  aaa tac acg ggt gcc  aac tta aaa tca gtc  att cga gtc        7104
Ser Gly  Lys Tyr Thr Gly Ala  Asn Leu Lys Ser Val  Ile Arg Val            
    2195                 2200                 2205                        

ctg cgg  ggt ttg cta gat caa  gga att cct tct aag  gag ctg gag        7149
Leu Arg  Gly Leu Leu Asp Gln  Gly Ile Pro Ser Lys  Glu Leu Glu            
    2210                 2215                 2220                        

aat ctt  caa gaa tta aaa cct  ttg gat cag tgt cta  att ggg caa        7194
Asn Leu  Gln Glu Leu Lys Pro  Leu Asp Gln Cys Leu  Ile Gly Gln            
    2225                 2230                 2235                        

act aag  gaa aac aga agg aag  aac aga tat aaa aat  ata ctt ccc        7239
Thr Lys  Glu Asn Arg Arg Lys  Asn Arg Tyr Lys Asn  Ile Leu Pro            
    2240                 2245                 2250                        

tat gat  gct aca aga gtg cct  ctt gga gat gaa ggt  ggc tat atc        7284
Tyr Asp  Ala Thr Arg Val Pro  Leu Gly Asp Glu Gly  Gly Tyr Ile            
    2255                 2260                 2265                        

aat gcc  agc ttc att aag ata  cca gtt ggg aaa gaa  gag ttc gtt        7329
Asn Ala  Ser Phe Ile Lys Ile  Pro Val Gly Lys Glu  Glu Phe Val            
    2270                 2275                 2280                        

tac att  gcc tgc caa gga cca  ctg cct aca act gtt  gga gac ttc        7374
Tyr Ile  Ala Cys Gln Gly Pro  Leu Pro Thr Thr Val  Gly Asp Phe            
    2285                 2290                 2295                        

tgg cag  atg att tgg gag caa  aaa tcc aca gtg ata  gcc atg atg        7419
Trp Gln  Met Ile Trp Glu Gln  Lys Ser Thr Val Ile  Ala Met Met            
    2300                 2305                 2310                        

act caa  gaa gta gaa gga gaa  aaa atc aaa tgc cag  cgc tat tgg        7464
Thr Gln  Glu Val Glu Gly Glu  Lys Ile Lys Cys Gln  Arg Tyr Trp            
    2315                 2320                 2325                        

ccc aac  atc cta ggc aaa aca  aca atg gtc agc aac  aga ctt cga        7509
Pro Asn  Ile Leu Gly Lys Thr  Thr Met Val Ser Asn  Arg Leu Arg            
    2330                 2335                 2340                        

ctg gct  ctt gtg aga atg cag  cag ctg aag ggc ttt  gtg gtg agg        7554
Leu Ala  Leu Val Arg Met Gln  Gln Leu Lys Gly Phe  Val Val Arg            
    2345                 2350                 2355                        

gca atg  acc ctt gaa gat att  cag acc aga gag gtg  cgc cat att        7599
Ala Met  Thr Leu Glu Asp Ile  Gln Thr Arg Glu Val  Arg His Ile            
    2360                 2365                 2370                        

tct cat  ctg aat ttc act gcc  tgg cca gac cat gat  aca cct tct        7644
Ser His  Leu Asn Phe Thr Ala  Trp Pro Asp His Asp  Thr Pro Ser            
    2375                 2380                 2385                        

caa cca  gat gat ctg ctt act  ttt atc tcc tac atg  aga cac atc        7689
Gln Pro  Asp Asp Leu Leu Thr  Phe Ile Ser Tyr Met  Arg His Ile            
    2390                 2395                 2400                        

cac aga  tca ggc cca atc att  acg cac tgc agt gct  ggc att gga        7734
His Arg  Ser Gly Pro Ile Ile  Thr His Cys Ser Ala  Gly Ile Gly            
    2405                 2410                 2415                        

cgt tca  ggg acc ctg att tgc  ata gat gtg gtt ctg  gga tta atc        7779
Arg Ser  Gly Thr Leu Ile Cys  Ile Asp Val Val Leu  Gly Leu Ile            
    2420                 2425                 2430                        

agt cag  gat ctt gat ttt gac  atc tct gat ttg gtg  cgc tgc atg        7824
Ser Gln  Asp Leu Asp Phe Asp  Ile Ser Asp Leu Val  Arg Cys Met            
    2435                 2440                 2445                        

aga cta  caa aga cac gga atg  gtt cag aca gag gat  caa tat att        7869
Arg Leu  Gln Arg His Gly Met  Val Gln Thr Glu Asp  Gln Tyr Ile            
    2450                 2455                 2460                        

ttc tgc  tat caa gtc atc ctt  tat gtc ctg aca cgt  ctt caa gca        7914
Phe Cys  Tyr Gln Val Ile Leu  Tyr Val Leu Thr Arg  Leu Gln Ala            
    2465                 2470                 2475                        

gaa gaa  gag caa aaa cag cag  cct cag ctt ctg aag  tga catgaaaaga     7963
Glu Glu  Glu Gln Lys Gln Gln  Pro Gln Leu Leu Lys                         
    2480                 2485                 2490                        

gcctctggat gcatttccat ttctctcctt aacctccagc agactcctgc tctctatcca     8023

aaataaagat cacagagcag caagttcata caacatgcat gttctcctct atcttagagg     8083

ggtattcttc ttgaaaataa aaaatattga aatgctgtat ttttacagct actttaacct     8143

atgataatta tttacaaaat tttaacacta accaaacaat gcagatctta gggatgatta     8203

aaggcagcat ttgatgatag cagacattgt tacaaggaca tggtgagtct atttttaatg     8263

caccaatctt gtttatagca aaaatgtttt ccaatatttt aataaagtag ttattttata     8323

ggggatactt gaaaccagta tttaagcttt aaatgacagt aatattggca tagaaaaaag     8383

tagcaaatgt ttactgtatc aatttctaat gtttactata tagaatttcc tgtaatatat     8443

ttatatactt tttcatgaaa atggagttat cagttatctg tttgttactg catcatctgt     8503

ttgtaatcat tatctcactt tgtaaataaa aacacacctt aaaacatgaa caagccaaaa     8563

ctgtgtgcag acaaaaaaaa aaaaa                                           8588


<210>  42
<211>  2490
<212>  PRT
<213>  Homo sapiens

<400>  42

Met His Val Ser Leu Ala Glu Ala Leu Glu Val Arg Gly Gly Pro Leu 
1               5                   10                  15      


Gln Glu Glu Glu Ile Trp Ala Val Leu Asn Gln Ser Ala Glu Ser Leu 
            20                  25                  30          


Gln Glu Leu Phe Arg Lys Val Ser Leu Ala Asp Pro Ala Ala Leu Gly 
        35                  40                  45              


Phe Ile Ile Ser Pro Trp Ser Leu Leu Leu Leu Pro Ser Gly Ser Val 
    50                  55                  60                  


Ser Phe Thr Asp Glu Asn Ile Ser Asn Gln Asp Leu Arg Ala Phe Thr 
65                  70                  75                  80  


Ala Pro Glu Val Leu Gln Asn Gln Ser Leu Thr Ser Leu Ser Asp Val 
                85                  90                  95      


Glu Lys Ile His Ile Tyr Ser Leu Gly Met Thr Leu Tyr Trp Gly Ala 
            100                 105                 110         


Asp Tyr Glu Val Pro Gln Ser Gln Pro Ile Lys Leu Gly Asp His Leu 
        115                 120                 125             


Asn Ser Ile Leu Leu Gly Met Cys Glu Asp Val Ile Tyr Ala Arg Val 
    130                 135                 140                 


Ser Val Arg Thr Val Leu Asp Ala Cys Ser Ala His Ile Arg Asn Ser 
145                 150                 155                 160 


Asn Cys Ala Pro Ser Phe Ser Tyr Val Lys His Leu Val Lys Leu Val 
                165                 170                 175     


Leu Gly Asn Leu Ser Gly Thr Asp Gln Leu Ser Cys Asn Ser Glu Gln 
            180                 185                 190         


Lys Pro Asp Arg Ser Gln Ala Ile Arg Asp Arg Leu Arg Gly Lys Gly 
        195                 200                 205             


Leu Pro Thr Gly Arg Ser Ser Thr Ser Asp Val Leu Asp Ile Gln Lys 
    210                 215                 220                 


Pro Pro Leu Ser His Gln Thr Phe Leu Asn Lys Gly Leu Ser Lys Ser 
225                 230                 235                 240 


Met Gly Phe Leu Ser Ile Lys Asp Thr Gln Asp Glu Asn Tyr Phe Lys 
                245                 250                 255     


Asp Ile Leu Ser Asp Asn Ser Gly Arg Glu Asp Ser Glu Asn Thr Phe 
            260                 265                 270         


Ser Pro Tyr Gln Phe Lys Thr Ser Gly Pro Glu Lys Lys Pro Ile Pro 
        275                 280                 285             


Gly Ile Asp Val Leu Ser Lys Lys Lys Ile Trp Ala Ser Ser Met Asp 
    290                 295                 300                 


Leu Leu Cys Thr Ala Asp Arg Asp Phe Ser Ser Gly Glu Thr Ala Thr 
305                 310                 315                 320 


Tyr Arg Arg Cys His Pro Glu Ala Val Thr Val Arg Thr Ser Thr Thr 
                325                 330                 335     


Pro Arg Lys Lys Glu Ala Arg Tyr Ser Asp Gly Ser Ile Ala Leu Asp 
            340                 345                 350         


Ile Phe Gly Pro Gln Lys Met Asp Pro Ile Tyr His Thr Arg Glu Leu 
        355                 360                 365             


Pro Thr Ser Ser Ala Ile Ser Ser Ala Leu Asp Arg Ile Arg Glu Arg 
    370                 375                 380                 


Gln Lys Lys Leu Gln Val Leu Arg Glu Ala Met Asn Val Glu Glu Pro 
385                 390                 395                 400 


Val Arg Arg Tyr Lys Thr Tyr His Gly Asp Val Phe Ser Thr Ser Ser 
                405                 410                 415     


Glu Ser Pro Ser Ile Ile Ser Ser Glu Ser Asp Phe Arg Gln Val Arg 
            420                 425                 430         


Arg Ser Glu Ala Ser Lys Arg Phe Glu Ser Ser Ser Gly Leu Pro Gly 
        435                 440                 445             


Val Asp Glu Thr Leu Ser Gln Gly Gln Ser Gln Arg Pro Ser Arg Gln 
    450                 455                 460                 


Tyr Glu Thr Pro Phe Glu Gly Asn Leu Ile Asn Gln Glu Ile Met Leu 
465                 470                 475                 480 


Lys Arg Gln Glu Glu Glu Leu Met Gln Leu Gln Ala Lys Met Ala Leu 
                485                 490                 495     


Arg Gln Ser Arg Leu Ser Leu Tyr Pro Gly Asp Thr Ile Lys Ala Ser 
            500                 505                 510         


Met Leu Asp Ile Thr Arg Asp Pro Leu Arg Glu Ile Ala Leu Glu Thr 
        515                 520                 525             


Ala Met Thr Gln Arg Lys Leu Arg Asn Phe Phe Gly Pro Glu Phe Val 
    530                 535                 540                 


Lys Met Thr Ile Glu Pro Phe Ile Ser Leu Asp Leu Pro Arg Ser Ile 
545                 550                 555                 560 


Leu Thr Lys Lys Gly Lys Asn Glu Asp Asn Arg Arg Lys Val Asn Ile 
                565                 570                 575     


Met Leu Leu Asn Gly Gln Arg Leu Glu Leu Thr Cys Asp Thr Lys Thr 
            580                 585                 590         


Ile Cys Lys Asp Val Phe Asp Met Val Val Ala His Ile Gly Leu Val 
        595                 600                 605             


Glu His His Leu Phe Ala Leu Ala Thr Leu Lys Asp Asn Glu Tyr Phe 
    610                 615                 620                 


Phe Val Asp Pro Asp Leu Lys Leu Thr Lys Val Ala Pro Glu Gly Trp 
625                 630                 635                 640 


Lys Glu Glu Pro Lys Lys Lys Thr Lys Ala Thr Val Asn Phe Thr Leu 
                645                 650                 655     


Phe Phe Arg Ile Lys Phe Phe Met Asp Asp Val Ser Leu Ile Gln His 
            660                 665                 670         


Thr Leu Thr Cys His Gln Tyr Tyr Leu Gln Leu Arg Lys Asp Ile Leu 
        675                 680                 685             


Glu Glu Arg Met His Cys Asp Asp Glu Thr Ser Leu Leu Leu Ala Ser 
    690                 695                 700                 


Leu Ala Leu Gln Ala Glu Tyr Gly Asp Tyr Gln Pro Glu Val His Gly 
705                 710                 715                 720 


Val Ser Tyr Phe Arg Met Glu His Tyr Leu Pro Ala Arg Val Met Glu 
                725                 730                 735     


Lys Leu Asp Leu Ser Tyr Ile Lys Glu Glu Leu Pro Lys Leu His Asn 
            740                 745                 750         


Thr Tyr Val Gly Ala Ser Glu Lys Glu Thr Glu Leu Glu Phe Leu Lys 
        755                 760                 765             


Val Cys Gln Arg Leu Thr Glu Tyr Gly Val His Phe His Arg Val His 
    770                 775                 780                 


Pro Glu Lys Lys Ser Gln Thr Gly Ile Leu Leu Gly Val Cys Ser Lys 
785                 790                 795                 800 


Gly Val Leu Val Phe Glu Val His Asn Gly Val Arg Thr Leu Val Leu 
                805                 810                 815     


Arg Phe Pro Trp Arg Glu Thr Lys Lys Ile Ser Phe Ser Lys Lys Lys 
            820                 825                 830         


Ile Thr Leu Gln Asn Thr Ser Asp Gly Ile Lys His Gly Phe Gln Thr 
        835                 840                 845             


Asp Asn Ser Lys Ile Cys Gln Tyr Leu Leu His Leu Cys Ser Tyr Gln 
    850                 855                 860                 


His Lys Phe Gln Leu Gln Met Arg Ala Arg Gln Ser Asn Gln Asp Ala 
865                 870                 875                 880 


Gln Asp Ile Glu Arg Ala Ser Phe Arg Ser Leu Asn Leu Gln Ala Glu 
                885                 890                 895     


Ser Val Arg Gly Phe Asn Met Gly Arg Ala Ile Ser Thr Gly Ser Leu 
            900                 905                 910         


Ala Ser Ser Thr Leu Asn Lys Leu Ala Val Arg Pro Leu Ser Val Gln 
        915                 920                 925             


Ala Glu Ile Leu Lys Arg Leu Ser Cys Ser Glu Leu Ser Leu Tyr Gln 
    930                 935                 940                 


Pro Leu Gln Asn Ser Ser Lys Glu Lys Asn Asp Lys Ala Ser Trp Glu 
945                 950                 955                 960 


Glu Lys Pro Arg Glu Met Ser Lys Ser Tyr His Asp Leu Ser Gln Ala 
                965                 970                 975     


Ser Leu Tyr Pro His Arg Lys Asn Val Ile Val Asn Met Glu Pro Pro 
            980                 985                 990         


Pro Gln Thr Val Ala Glu Leu Val  Gly Lys Pro Ser His  Gln Met Ser 
        995                 1000                 1005             


Arg Ser  Asp Ala Glu Ser Leu  Ala Gly Val Thr Lys  Leu Asn Asn 
    1010                 1015                 1020             


Ser Lys  Ser Val Ala Ser Leu  Asn Arg Ser Pro Glu  Arg Arg Lys 
    1025                 1030                 1035             


His Glu  Ser Asp Ser Ser Ser  Ile Glu Asp Pro Gly  Gln Ala Tyr 
    1040                 1045                 1050             


Val Leu  Gly Met Thr Met His  Ser Ser Gly Asn Ser  Ser Ser Gln 
    1055                 1060                 1065             


Val Pro  Leu Lys Glu Asn Asp  Val Leu His Lys Arg  Trp Ser Ile 
    1070                 1075                 1080             


Val Ser  Ser Pro Glu Arg Glu  Ile Thr Leu Val Asn  Leu Lys Lys 
    1085                 1090                 1095             


Asp Ala  Lys Tyr Gly Leu Gly  Phe Gln Ile Ile Gly  Gly Glu Lys 
    1100                 1105                 1110             


Met Gly  Arg Leu Asp Leu Gly  Ile Phe Ile Ser Ser  Val Ala Pro 
    1115                 1120                 1125             


Gly Gly  Pro Ala Asp Leu Asp  Gly Cys Leu Lys Pro  Gly Asp Arg 
    1130                 1135                 1140             


Leu Ile  Ser Val Asn Ser Val  Ser Leu Glu Gly Val  Ser His His 
    1145                 1150                 1155             


Ala Ala  Ile Glu Ile Leu Gln  Asn Ala Pro Glu Asp  Val Thr Leu 
    1160                 1165                 1170             


Val Ile  Ser Gln Pro Lys Glu  Lys Ile Ser Lys Val  Pro Ser Thr 
    1175                 1180                 1185             


Pro Val  His Leu Thr Asn Glu  Met Lys Asn Tyr Met  Lys Lys Ser 
    1190                 1195                 1200             


Ser Tyr  Met Gln Asp Ser Ala  Ile Asp Ser Ser Ser  Lys Asp His 
    1205                 1210                 1215             


His Trp  Ser Arg Gly Thr Leu  Arg His Ile Ser Glu  Asn Ser Phe 
    1220                 1225                 1230             


Gly Pro  Ser Gly Gly Leu Arg  Glu Gly Ser Leu Ser  Ser Gln Asp 
    1235                 1240                 1245             


Ser Arg  Thr Glu Ser Ala Ser  Leu Ser Gln Ser Gln  Val Asn Gly 
    1250                 1255                 1260             


Phe Phe  Ala Ser His Leu Gly  Asp Gln Thr Trp Gln  Glu Ser Gln 
    1265                 1270                 1275             


His Gly  Ser Pro Ser Pro Ser  Val Ile Ser Lys Ala  Thr Glu Lys 
    1280                 1285                 1290             


Glu Thr  Phe Thr Asp Ser Asn  Gln Ser Lys Thr Lys  Lys Pro Gly 
    1295                 1300                 1305             


Ile Ser  Asp Val Thr Asp Tyr  Ser Asp Arg Gly Asp  Ser Asp Met 
    1310                 1315                 1320             


Asp Glu  Ala Thr Tyr Ser Ser  Ser Gln Asp His Gln  Thr Pro Lys 
    1325                 1330                 1335             


Gln Glu  Ser Ser Ser Ser Val  Asn Thr Ser Asn Lys  Met Asn Phe 
    1340                 1345                 1350             


Lys Thr  Phe Ser Ser Ser Pro  Pro Lys Pro Gly Asp  Ile Phe Glu 
    1355                 1360                 1365             


Val Glu  Leu Ala Lys Asn Asp  Asn Ser Leu Gly Ile  Ser Val Thr 
    1370                 1375                 1380             


Val Leu  Phe Asp Lys Gly Gly  Val Asn Thr Ser Val  Arg His Gly 
    1385                 1390                 1395             


Gly Ile  Tyr Val Lys Ala Val  Ile Pro Gln Gly Ala  Ala Glu Ser 
    1400                 1405                 1410             


Asp Gly  Arg Ile His Lys Gly  Asp Arg Val Leu Ala  Val Asn Gly 
    1415                 1420                 1425             


Val Ser  Leu Glu Gly Ala Thr  His Lys Gln Ala Val  Glu Thr Leu 
    1430                 1435                 1440             


Arg Asn  Thr Gly Gln Val Val  His Leu Leu Leu Glu  Lys Gly Gln 
    1445                 1450                 1455             


Ser Pro  Thr Ser Lys Glu His  Val Pro Val Thr Pro  Gln Cys Thr 
    1460                 1465                 1470             


Leu Ser  Asp Gln Asn Ala Gln  Gly Gln Gly Pro Glu  Lys Val Lys 
    1475                 1480                 1485             


Lys Thr  Thr Gln Val Lys Asp  Tyr Ser Phe Val Thr  Glu Glu Asn 
    1490                 1495                 1500             


Thr Phe  Glu Val Lys Leu Phe  Lys Asn Ser Ser Gly  Leu Gly Phe 
    1505                 1510                 1515             


Ser Phe  Ser Arg Glu Asp Asn  Leu Ile Pro Glu Gln  Ile Asn Ala 
    1520                 1525                 1530             


Ser Ile  Val Arg Val Lys Lys  Leu Phe Pro Gly Gln  Pro Ala Ala 
    1535                 1540                 1545             


Glu Ser  Gly Lys Ile Asp Val  Gly Asp Val Ile Leu  Lys Val Asn 
    1550                 1555                 1560             


Gly Ala  Ser Leu Lys Gly Leu  Ser Gln Gln Glu Val  Ile Ser Ala 
    1565                 1570                 1575             


Leu Arg  Gly Thr Ala Pro Glu  Val Phe Leu Leu Leu  Cys Arg Pro 
    1580                 1585                 1590             


Pro Pro  Gly Val Leu Pro Glu  Ile Asp Thr Ala Leu  Leu Thr Pro 
    1595                 1600                 1605             


Leu Gln  Ser Pro Ala Gln Val  Leu Pro Asn Ser Ser  Lys Asp Ser 
    1610                 1615                 1620             


Ser Gln  Pro Ser Cys Val Glu  Gln Ser Thr Ser Ser  Asp Glu Asn 
    1625                 1630                 1635             


Glu Met  Ser Asp Lys Ser Lys  Lys Gln Cys Lys Ser  Pro Ser Arg 
    1640                 1645                 1650             


Arg Asp  Ser Tyr Ser Asp Ser  Ser Gly Ser Gly Glu  Asp Asp Leu 
    1655                 1660                 1665             


Val Thr  Ala Pro Ala Asn Ile  Ser Asn Ser Thr Trp  Ser Ser Ala 
    1670                 1675                 1680             


Leu His  Gln Thr Leu Ser Asn  Met Val Ser Gln Ala  Gln Ser His 
    1685                 1690                 1695             


His Glu  Ala Pro Lys Ser Gln  Glu Asp Thr Ile Cys  Thr Met Phe 
    1700                 1705                 1710             


Tyr Tyr  Pro Gln Lys Ile Pro  Asn Lys Pro Glu Phe  Glu Asp Ser 
    1715                 1720                 1725             


Asn Pro  Ser Pro Leu Pro Pro  Asp Met Ala Pro Gly  Gln Ser Tyr 
    1730                 1735                 1740             


Gln Pro  Gln Ser Glu Ser Ala  Ser Ser Ser Ser Met  Asp Lys Tyr 
    1745                 1750                 1755             


His Ile  His His Ile Ser Glu  Pro Thr Arg Gln Glu  Asn Trp Thr 
    1760                 1765                 1770             


Pro Leu  Lys Asn Asp Leu Glu  Asn His Leu Glu Asp  Phe Glu Leu 
    1775                 1780                 1785             


Glu Val  Glu Leu Leu Ile Thr  Leu Ile Lys Ser Glu  Lys Gly Ser 
    1790                 1795                 1800             


Leu Gly  Phe Thr Val Thr Lys  Gly Asn Gln Arg Ile  Gly Cys Tyr 
    1805                 1810                 1815             


Val His  Asp Val Ile Gln Asp  Pro Ala Lys Ser Asp  Gly Arg Leu 
    1820                 1825                 1830             


Lys Pro  Gly Asp Arg Leu Ile  Lys Val Asn Asp Thr  Asp Val Thr 
    1835                 1840                 1845             


Asn Met  Thr His Thr Asp Ala  Val Asn Leu Leu Arg  Ala Ala Ser 
    1850                 1855                 1860             


Lys Thr  Val Arg Leu Val Ile  Gly Arg Val Leu Glu  Leu Pro Arg 
    1865                 1870                 1875             


Ile Pro  Met Leu Pro His Leu  Leu Pro Asp Ile Thr  Leu Thr Cys 
    1880                 1885                 1890             


Asn Lys  Glu Glu Leu Gly Phe  Ser Leu Cys Gly Gly  His Asp Ser 
    1895                 1900                 1905             


Leu Tyr  Gln Val Val Tyr Ile  Ser Asp Ile Asn Pro  Arg Ser Val 
    1910                 1915                 1920             


Ala Ala  Ile Glu Gly Asn Leu  Gln Leu Leu Asp Val  Ile His Tyr 
    1925                 1930                 1935             


Val Asn  Gly Val Ser Thr Gln  Gly Met Thr Leu Glu  Glu Val Asn 
    1940                 1945                 1950             


Arg Ala  Leu Asp Met Ser Leu  Pro Ser Leu Val Leu  Lys Ala Thr 
    1955                 1960                 1965             


Arg Asn  Asp Leu Pro Val Val  Pro Ser Ser Lys Arg  Ser Ala Val 
    1970                 1975                 1980             


Ser Ala  Pro Lys Ser Thr Lys  Gly Asn Gly Ser Tyr  Ser Val Gly 
    1985                 1990                 1995             


Ser Cys  Ser Gln Pro Ala Leu  Thr Pro Asn Asp Ser  Phe Ser Thr 
    2000                 2005                 2010             


Val Ala  Gly Glu Glu Ile Asn  Glu Ile Ser Tyr Pro  Lys Gly Lys 
    2015                 2020                 2025             


Cys Ser  Thr Tyr Gln Ile Lys  Gly Ser Pro Asn Leu  Thr Leu Pro 
    2030                 2035                 2040             


Lys Glu  Ser Tyr Ile Gln Glu  Asp Asp Ile Tyr Asp  Asp Ser Gln 
    2045                 2050                 2055             


Glu Ala  Glu Val Ile Gln Ser  Leu Leu Asp Val Val  Asp Glu Glu 
    2060                 2065                 2070             


Ala Gln  Asn Leu Leu Asn Glu  Asn Asn Ala Ala Gly  Tyr Ser Cys 
    2075                 2080                 2085             


Gly Pro  Gly Thr Leu Lys Met  Asn Gly Lys Leu Ser  Glu Glu Arg 
    2090                 2095                 2100             


Thr Glu  Asp Thr Asp Cys Asp  Gly Ser Pro Leu Pro  Glu Tyr Phe 
    2105                 2110                 2115             


Thr Glu  Ala Thr Lys Met Asn  Gly Cys Glu Glu Tyr  Cys Glu Glu 
    2120                 2125                 2130             


Lys Val  Lys Ser Glu Ser Leu  Ile Gln Lys Pro Gln  Glu Lys Lys 
    2135                 2140                 2145             


Thr Asp  Asp Asp Glu Ile Thr  Trp Gly Asn Asp Glu  Leu Pro Ile 
    2150                 2155                 2160             


Glu Arg  Thr Asn His Glu Asp  Ser Asp Lys Asp His  Ser Phe Leu 
    2165                 2170                 2175             


Thr Asn  Asp Glu Leu Ala Val  Leu Pro Val Val Lys  Val Leu Pro 
    2180                 2185                 2190             


Ser Gly  Lys Tyr Thr Gly Ala  Asn Leu Lys Ser Val  Ile Arg Val 
    2195                 2200                 2205             


Leu Arg  Gly Leu Leu Asp Gln  Gly Ile Pro Ser Lys  Glu Leu Glu 
    2210                 2215                 2220             


Asn Leu  Gln Glu Leu Lys Pro  Leu Asp Gln Cys Leu  Ile Gly Gln 
    2225                 2230                 2235             


Thr Lys  Glu Asn Arg Arg Lys  Asn Arg Tyr Lys Asn  Ile Leu Pro 
    2240                 2245                 2250             


Tyr Asp  Ala Thr Arg Val Pro  Leu Gly Asp Glu Gly  Gly Tyr Ile 
    2255                 2260                 2265             


Asn Ala  Ser Phe Ile Lys Ile  Pro Val Gly Lys Glu  Glu Phe Val 
    2270                 2275                 2280             


Tyr Ile  Ala Cys Gln Gly Pro  Leu Pro Thr Thr Val  Gly Asp Phe 
    2285                 2290                 2295             


Trp Gln  Met Ile Trp Glu Gln  Lys Ser Thr Val Ile  Ala Met Met 
    2300                 2305                 2310             


Thr Gln  Glu Val Glu Gly Glu  Lys Ile Lys Cys Gln  Arg Tyr Trp 
    2315                 2320                 2325             


Pro Asn  Ile Leu Gly Lys Thr  Thr Met Val Ser Asn  Arg Leu Arg 
    2330                 2335                 2340             


Leu Ala  Leu Val Arg Met Gln  Gln Leu Lys Gly Phe  Val Val Arg 
    2345                 2350                 2355             


Ala Met  Thr Leu Glu Asp Ile  Gln Thr Arg Glu Val  Arg His Ile 
    2360                 2365                 2370             


Ser His  Leu Asn Phe Thr Ala  Trp Pro Asp His Asp  Thr Pro Ser 
    2375                 2380                 2385             


Gln Pro  Asp Asp Leu Leu Thr  Phe Ile Ser Tyr Met  Arg His Ile 
    2390                 2395                 2400             


His Arg  Ser Gly Pro Ile Ile  Thr His Cys Ser Ala  Gly Ile Gly 
    2405                 2410                 2415             


Arg Ser  Gly Thr Leu Ile Cys  Ile Asp Val Val Leu  Gly Leu Ile 
    2420                 2425                 2430             


Ser Gln  Asp Leu Asp Phe Asp  Ile Ser Asp Leu Val  Arg Cys Met 
    2435                 2440                 2445             


Arg Leu  Gln Arg His Gly Met  Val Gln Thr Glu Asp  Gln Tyr Ile 
    2450                 2455                 2460             


Phe Cys  Tyr Gln Val Ile Leu  Tyr Val Leu Thr Arg  Leu Gln Ala 
    2465                 2470                 2475             


Glu Glu  Glu Gln Lys Gln Gln  Pro Gln Leu Leu Lys  
    2480                 2485                 2490 


<210>  43
<211>  1683
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (86)..(1591)

<400>  43
cgcgctctct cgctctcagg gcccccctcg ctcccccggc cgcagtccgt gcgcgagggc       60

gccggcgagc cgtctcggaa gcagc atg cag gcg cgc tac tcc gtg tcc gac        112
                            Met Gln Ala Arg Tyr Ser Val Ser Asp           
                            1               5                             

ccc aac gcc ctg gga gtg gtg ccc tac ctg agc gag cag aat tac tac        160
Pro Asn Ala Leu Gly Val Val Pro Tyr Leu Ser Glu Gln Asn Tyr Tyr           
10                  15                  20                  25            

cgg gct gcg ggc agc tac ggc ggc atg gcc agc ccc atg ggc gtc tat        208
Arg Ala Ala Gly Ser Tyr Gly Gly Met Ala Ser Pro Met Gly Val Tyr           
                30                  35                  40                

tcc ggc cac ccg gag cag tac agc gcg ggg atg ggc cgc tcc tac gcg        256
Ser Gly His Pro Glu Gln Tyr Ser Ala Gly Met Gly Arg Ser Tyr Ala           
            45                  50                  55                    

ccc tac cac cac cac cag ccc gcg gcg cct aag gac ctg gtg aag ccg        304
Pro Tyr His His His Gln Pro Ala Ala Pro Lys Asp Leu Val Lys Pro           
        60                  65                  70                        

ccc tac agc tac atc gcg ctc atc acc atg gcc atc cag aac gcg ccc        352
Pro Tyr Ser Tyr Ile Ala Leu Ile Thr Met Ala Ile Gln Asn Ala Pro           
    75                  80                  85                            

gag aag aag atc acc ttg aac ggc atc tac cag ttc atc atg gac cgc        400
Glu Lys Lys Ile Thr Leu Asn Gly Ile Tyr Gln Phe Ile Met Asp Arg           
90                  95                  100                 105           

ttc ccc ttc tac cgg gag aac aag cag ggc tgg cag aac agc atc cgc        448
Phe Pro Phe Tyr Arg Glu Asn Lys Gln Gly Trp Gln Asn Ser Ile Arg           
                110                 115                 120               

cac aac ctc tcg ctc aac gag tgc ttc gtc aag gtg ccc cgc gac gac        496
His Asn Leu Ser Leu Asn Glu Cys Phe Val Lys Val Pro Arg Asp Asp           
            125                 130                 135                   

aag aag ccc ggc aag ggc agt tac tgg acc ctg gac ccg gac tcc tac        544
Lys Lys Pro Gly Lys Gly Ser Tyr Trp Thr Leu Asp Pro Asp Ser Tyr           
        140                 145                 150                       

aac atg ttc gag aac ggc agc ttc ctg cgg cgc cgg cgg cgc ttc aaa        592
Asn Met Phe Glu Asn Gly Ser Phe Leu Arg Arg Arg Arg Arg Phe Lys           
    155                 160                 165                           

aag aag gac gtg tcc aag gag aag gag gag cgg gcc cac ctc aag gag        640
Lys Lys Asp Val Ser Lys Glu Lys Glu Glu Arg Ala His Leu Lys Glu           
170                 175                 180                 185           

ccg ccc ccg gcg gcg tcc aag ggc gcc ccg gcc acc ccc cac cta gcg        688
Pro Pro Pro Ala Ala Ser Lys Gly Ala Pro Ala Thr Pro His Leu Ala           
                190                 195                 200               

gac gcc ccc aag gag gcc gag aag aag gtg gtg atc aag agc gag gcg        736
Asp Ala Pro Lys Glu Ala Glu Lys Lys Val Val Ile Lys Ser Glu Ala           
            205                 210                 215                   

gcg tcc ccg gcg ctg ccg gtc atc acc aag gtg gag acg ctg agc ccc        784
Ala Ser Pro Ala Leu Pro Val Ile Thr Lys Val Glu Thr Leu Ser Pro           
        220                 225                 230                       

gag agc gcg ctg cag ggc agc ccg cgc agc gcg gcc tcc acg ccc gcc        832
Glu Ser Ala Leu Gln Gly Ser Pro Arg Ser Ala Ala Ser Thr Pro Ala           
    235                 240                 245                           

ggc tcc ccc gac ggc tcg ctg ccg gag cac cac gcc gcg gcg ccc aac        880
Gly Ser Pro Asp Gly Ser Leu Pro Glu His His Ala Ala Ala Pro Asn           
250                 255                 260                 265           

ggg ctg cct ggc ttc agc gtg gag aac atc atg acc ctg cga acg tcg        928
Gly Leu Pro Gly Phe Ser Val Glu Asn Ile Met Thr Leu Arg Thr Ser           
                270                 275                 280               

ccg ccg ggc gga gag ctg agc ccg ggg gcc gga cgc gcg ggc ctg gtg        976
Pro Pro Gly Gly Glu Leu Ser Pro Gly Ala Gly Arg Ala Gly Leu Val           
            285                 290                 295                   

gtg ccg ccg ctg gcg ctg ccc tac gcc gcc gcg ccg ccc gcc gcc tac       1024
Val Pro Pro Leu Ala Leu Pro Tyr Ala Ala Ala Pro Pro Ala Ala Tyr           
        300                 305                 310                       

ggc cag ccg tgc gct cag ggc ctg gag gcc ggg gcc gcc ggg ggc tac       1072
Gly Gln Pro Cys Ala Gln Gly Leu Glu Ala Gly Ala Ala Gly Gly Tyr           
    315                 320                 325                           

cag tgc agc atg cga gcg atg agc ctg tac acc ggg gcc gag cgg ccg       1120
Gln Cys Ser Met Arg Ala Met Ser Leu Tyr Thr Gly Ala Glu Arg Pro           
330                 335                 340                 345           

gcg cac atg tgc gtc ccg ccc gcc ctg gac gag gcc ctc tcg gac cac       1168
Ala His Met Cys Val Pro Pro Ala Leu Asp Glu Ala Leu Ser Asp His           
                350                 355                 360               

ccg agc ggc ccc acg tcg ccc ctg agc gct ctc aac ctc gcc gcc ggc       1216
Pro Ser Gly Pro Thr Ser Pro Leu Ser Ala Leu Asn Leu Ala Ala Gly           
            365                 370                 375                   

cag gag ggc gcg ctc gcc gcc acg ggc cac cac cac cag cac cac ggc       1264
Gln Glu Gly Ala Leu Ala Ala Thr Gly His His His Gln His His Gly           
        380                 385                 390                       

cac cac cac ccg cag gcg ccg ccg ccc ccg ccg gct ccc cag ccc cag       1312
His His His Pro Gln Ala Pro Pro Pro Pro Pro Ala Pro Gln Pro Gln           
    395                 400                 405                           

ccg acg ccg cag ccc ggg gcc gcc gcg gcg cag gcg gcc tcc tgg tat       1360
Pro Thr Pro Gln Pro Gly Ala Ala Ala Ala Gln Ala Ala Ser Trp Tyr           
410                 415                 420                 425           

ctc aac cac agc ggg gac ctg aac cac ctc ccc ggc cac acg ttc gcg       1408
Leu Asn His Ser Gly Asp Leu Asn His Leu Pro Gly His Thr Phe Ala           
                430                 435                 440               

gcc cag cag caa act ttc ccc aac gtg cgg gag atg ttc aac tcc cac       1456
Ala Gln Gln Gln Thr Phe Pro Asn Val Arg Glu Met Phe Asn Ser His           
            445                 450                 455                   

cgg ctg ggg att gag aac tcg acc ctc ggg gag tcc cag gtg agt ggc       1504
Arg Leu Gly Ile Glu Asn Ser Thr Leu Gly Glu Ser Gln Val Ser Gly           
        460                 465                 470                       

aat gcc agc tgc cag ctg ccc tac aga tcc acg ccg cct ctc tat cgc       1552
Asn Ala Ser Cys Gln Leu Pro Tyr Arg Ser Thr Pro Pro Leu Tyr Arg           
    475                 480                 485                           

cac gca gcc ccc tac tcc tac gac tgc acg aaa tac tga cgtgtcccgg        1601
His Ala Ala Pro Tyr Ser Tyr Asp Cys Thr Lys Tyr                           
490                 495                 500                               

gacctcccct ccccggcccg ctccggcttc gcttcccagc cccgacccaa ccagacaatt     1661

aaggggctgc agagacgcaa aa                                              1683


<210>  44
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Gln Ala Arg Tyr Ser Val Ser Asp Pro Asn Ala Leu Gly Val Val 
1               5                   10                  15      


Pro Tyr Leu Ser Glu Gln Asn Tyr Tyr Arg Ala Ala Gly Ser Tyr Gly 
            20                  25                  30          


Gly Met Ala Ser Pro Met Gly Val Tyr Ser Gly His Pro Glu Gln Tyr 
        35                  40                  45              


Ser Ala Gly Met Gly Arg Ser Tyr Ala Pro Tyr His His His Gln Pro 
    50                  55                  60                  


Ala Ala Pro Lys Asp Leu Val Lys Pro Pro Tyr Ser Tyr Ile Ala Leu 
65                  70                  75                  80  


Ile Thr Met Ala Ile Gln Asn Ala Pro Glu Lys Lys Ile Thr Leu Asn 
                85                  90                  95      


Gly Ile Tyr Gln Phe Ile Met Asp Arg Phe Pro Phe Tyr Arg Glu Asn 
            100                 105                 110         


Lys Gln Gly Trp Gln Asn Ser Ile Arg His Asn Leu Ser Leu Asn Glu 
        115                 120                 125             


Cys Phe Val Lys Val Pro Arg Asp Asp Lys Lys Pro Gly Lys Gly Ser 
    130                 135                 140                 


Tyr Trp Thr Leu Asp Pro Asp Ser Tyr Asn Met Phe Glu Asn Gly Ser 
145                 150                 155                 160 


Phe Leu Arg Arg Arg Arg Arg Phe Lys Lys Lys Asp Val Ser Lys Glu 
                165                 170                 175     


Lys Glu Glu Arg Ala His Leu Lys Glu Pro Pro Pro Ala Ala Ser Lys 
            180                 185                 190         


Gly Ala Pro Ala Thr Pro His Leu Ala Asp Ala Pro Lys Glu Ala Glu 
        195                 200                 205             


Lys Lys Val Val Ile Lys Ser Glu Ala Ala Ser Pro Ala Leu Pro Val 
    210                 215                 220                 


Ile Thr Lys Val Glu Thr Leu Ser Pro Glu Ser Ala Leu Gln Gly Ser 
225                 230                 235                 240 


Pro Arg Ser Ala Ala Ser Thr Pro Ala Gly Ser Pro Asp Gly Ser Leu 
                245                 250                 255     


Pro Glu His His Ala Ala Ala Pro Asn Gly Leu Pro Gly Phe Ser Val 
            260                 265                 270         


Glu Asn Ile Met Thr Leu Arg Thr Ser Pro Pro Gly Gly Glu Leu Ser 
        275                 280                 285             


Pro Gly Ala Gly Arg Ala Gly Leu Val Val Pro Pro Leu Ala Leu Pro 
    290                 295                 300                 


Tyr Ala Ala Ala Pro Pro Ala Ala Tyr Gly Gln Pro Cys Ala Gln Gly 
305                 310                 315                 320 


Leu Glu Ala Gly Ala Ala Gly Gly Tyr Gln Cys Ser Met Arg Ala Met 
                325                 330                 335     


Ser Leu Tyr Thr Gly Ala Glu Arg Pro Ala His Met Cys Val Pro Pro 
            340                 345                 350         


Ala Leu Asp Glu Ala Leu Ser Asp His Pro Ser Gly Pro Thr Ser Pro 
        355                 360                 365             


Leu Ser Ala Leu Asn Leu Ala Ala Gly Gln Glu Gly Ala Leu Ala Ala 
    370                 375                 380                 


Thr Gly His His His Gln His His Gly His His His Pro Gln Ala Pro 
385                 390                 395                 400 


Pro Pro Pro Pro Ala Pro Gln Pro Gln Pro Thr Pro Gln Pro Gly Ala 
                405                 410                 415     


Ala Ala Ala Gln Ala Ala Ser Trp Tyr Leu Asn His Ser Gly Asp Leu 
            420                 425                 430         


Asn His Leu Pro Gly His Thr Phe Ala Ala Gln Gln Gln Thr Phe Pro 
        435                 440                 445             


Asn Val Arg Glu Met Phe Asn Ser His Arg Leu Gly Ile Glu Asn Ser 
    450                 455                 460                 


Thr Leu Gly Glu Ser Gln Val Ser Gly Asn Ala Ser Cys Gln Leu Pro 
465                 470                 475                 480 


Tyr Arg Ser Thr Pro Pro Leu Tyr Arg His Ala Ala Pro Tyr Ser Tyr 
                485                 490                 495     


Asp Cys Thr Lys Tyr 
            500     


<210>  45
<211>  1271
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (75)..(905)

<400>  45
accgtagcga cgccgcggtc cgccggatct ccagcgctca gtccgcgccg caggtggtgc       60

ttgtctgcag agtc atg acc tct ttc cgc ttg gcc ctc atc cag ctt cag        110
                Met Thr Ser Phe Arg Leu Ala Leu Ile Gln Leu Gln           
                1               5                   10                    

att tct tcc atc aaa tca gat aac gtc act cgc gct tgt agc ttc atc        158
Ile Ser Ser Ile Lys Ser Asp Asn Val Thr Arg Ala Cys Ser Phe Ile           
        15                  20                  25                        

cgg gag gca gca acg caa gga gcc aaa ata gtt tct ttg ccg gaa tgc        206
Arg Glu Ala Ala Thr Gln Gly Ala Lys Ile Val Ser Leu Pro Glu Cys           
    30                  35                  40                            

ttt aat tct cca tat gga gcg aaa tat ttt cct gaa tat gca gag aaa        254
Phe Asn Ser Pro Tyr Gly Ala Lys Tyr Phe Pro Glu Tyr Ala Glu Lys           
45                  50                  55                  60            

att cct ggt gaa tcc aca cag aag ctt tct gaa gta gca aag gaa tgc        302
Ile Pro Gly Glu Ser Thr Gln Lys Leu Ser Glu Val Ala Lys Glu Cys           
                65                  70                  75                

agc ata tat ctc att gga ggc tct atc cct gaa gag gat gct ggg aaa        350
Ser Ile Tyr Leu Ile Gly Gly Ser Ile Pro Glu Glu Asp Ala Gly Lys           
            80                  85                  90                    

tta tat aac acc tgt gct gtg ttt ggg cct gat gga act tta cta gca        398
Leu Tyr Asn Thr Cys Ala Val Phe Gly Pro Asp Gly Thr Leu Leu Ala           
        95                  100                 105                       

aag tat aga aag atc cat ctg ttt gac att gat gtt cct gga aaa att        446
Lys Tyr Arg Lys Ile His Leu Phe Asp Ile Asp Val Pro Gly Lys Ile           
    110                 115                 120                           

aca ttt caa gaa tct aaa aca ttg agt ccg ggt gat agt ttc tcc aca        494
Thr Phe Gln Glu Ser Lys Thr Leu Ser Pro Gly Asp Ser Phe Ser Thr           
125                 130                 135                 140           

ttt gat act cct tac tgc aga gtg ggt ctg ggc atc tgc tac gac atg        542
Phe Asp Thr Pro Tyr Cys Arg Val Gly Leu Gly Ile Cys Tyr Asp Met           
                145                 150                 155               

cgg ttt gca gag ctt gca caa atc tac gca cag aga ggc tgc cag ctg        590
Arg Phe Ala Glu Leu Ala Gln Ile Tyr Ala Gln Arg Gly Cys Gln Leu           
            160                 165                 170                   

ttg gta tat cca gga gct ttt aat ctg acc act gga cca gcc cat tgg        638
Leu Val Tyr Pro Gly Ala Phe Asn Leu Thr Thr Gly Pro Ala His Trp           
        175                 180                 185                       

gag tta ctt cag cga agc cgg gct gtt gat aat cag gtg tat gtg gcc        686
Glu Leu Leu Gln Arg Ser Arg Ala Val Asp Asn Gln Val Tyr Val Ala           
    190                 195                 200                           

aca gcc tct cct gcc cgg gat gac aaa gcc tcc tat gtt gcc tgg gga        734
Thr Ala Ser Pro Ala Arg Asp Asp Lys Ala Ser Tyr Val Ala Trp Gly           
205                 210                 215                 220           

cac agc acc gtg gtg aac cct tgg ggg gag gtt cta gcc aaa gct ggc        782
His Ser Thr Val Val Asn Pro Trp Gly Glu Val Leu Ala Lys Ala Gly           
                225                 230                 235               

aca gaa gaa gca atc gtg tat tca gac ata gac ctg aag aag ctg gct        830
Thr Glu Glu Ala Ile Val Tyr Ser Asp Ile Asp Leu Lys Lys Leu Ala           
            240                 245                 250                   

gaa ata cgc cag caa atc ccc gtt ttt aga cag aag cga tca gac ctc        878
Glu Ile Arg Gln Gln Ile Pro Val Phe Arg Gln Lys Arg Ser Asp Leu           
        255                 260                 265                       

tat gct gtg gag atg aaa aag ccc taa agtttatgtt tctaatgtgt              925
Tyr Ala Val Glu Met Lys Lys Pro                                           
    270                 275                                               

cacagaatag gacgatatga ttctacaaca taatcaactc cctattaaat tctttaatga      985

agattttttt tttaattcgg ccttgtcctt cctaggttct ctattgagat gagaaagcct     1045

cattatgctg acattttcca cgccacatta aatagttaaa aaggatgcag cctggagcca     1105

gagagcagaa agctgggctg gttctgaagc ttcttccata cttaagttgc ctccaagcag     1165

tttgtgaaag tatcagatct tggtatcctg gtgattgatt cacctaatat aaatatattt     1225

gtgtcatgaa cctcttatcc cgttgctgga gttgtaatct ccatca                    1271


<210>  46
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Thr Ser Phe Arg Leu Ala Leu Ile Gln Leu Gln Ile Ser Ser Ile 
1               5                   10                  15      


Lys Ser Asp Asn Val Thr Arg Ala Cys Ser Phe Ile Arg Glu Ala Ala 
            20                  25                  30          


Thr Gln Gly Ala Lys Ile Val Ser Leu Pro Glu Cys Phe Asn Ser Pro 
        35                  40                  45              


Tyr Gly Ala Lys Tyr Phe Pro Glu Tyr Ala Glu Lys Ile Pro Gly Glu 
    50                  55                  60                  


Ser Thr Gln Lys Leu Ser Glu Val Ala Lys Glu Cys Ser Ile Tyr Leu 
65                  70                  75                  80  


Ile Gly Gly Ser Ile Pro Glu Glu Asp Ala Gly Lys Leu Tyr Asn Thr 
                85                  90                  95      


Cys Ala Val Phe Gly Pro Asp Gly Thr Leu Leu Ala Lys Tyr Arg Lys 
            100                 105                 110         


Ile His Leu Phe Asp Ile Asp Val Pro Gly Lys Ile Thr Phe Gln Glu 
        115                 120                 125             


Ser Lys Thr Leu Ser Pro Gly Asp Ser Phe Ser Thr Phe Asp Thr Pro 
    130                 135                 140                 


Tyr Cys Arg Val Gly Leu Gly Ile Cys Tyr Asp Met Arg Phe Ala Glu 
145                 150                 155                 160 


Leu Ala Gln Ile Tyr Ala Gln Arg Gly Cys Gln Leu Leu Val Tyr Pro 
                165                 170                 175     


Gly Ala Phe Asn Leu Thr Thr Gly Pro Ala His Trp Glu Leu Leu Gln 
            180                 185                 190         


Arg Ser Arg Ala Val Asp Asn Gln Val Tyr Val Ala Thr Ala Ser Pro 
        195                 200                 205             


Ala Arg Asp Asp Lys Ala Ser Tyr Val Ala Trp Gly His Ser Thr Val 
    210                 215                 220                 


Val Asn Pro Trp Gly Glu Val Leu Ala Lys Ala Gly Thr Glu Glu Ala 
225                 230                 235                 240 


Ile Val Tyr Ser Asp Ile Asp Leu Lys Lys Leu Ala Glu Ile Arg Gln 
                245                 250                 255     


Gln Ile Pro Val Phe Arg Gln Lys Arg Ser Asp Leu Tyr Ala Val Glu 
            260                 265                 270         


Met Lys Lys Pro 
        275     


<210>  47
<211>  7830
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (22)..(6213)

<400>  47
cccggagtga gttacgccac t atg gcg gac ggg gca ccc cgg ccc cag ctt         51
                        Met Ala Asp Gly Ala Pro Arg Pro Gln Leu           
                        1               5                   10            

tac cgc agc gtc tcg ttc aag ctg ctg gag cgc tgg agc ggc ggc ccc         99
Tyr Arg Ser Val Ser Phe Lys Leu Leu Glu Arg Trp Ser Gly Gly Pro           
                15                  20                  25                

ggg ctg agg gag gag gac acg gac acc ccc ggc ttg agg cga cgc gcc        147
Gly Leu Arg Glu Glu Asp Thr Asp Thr Pro Gly Leu Arg Arg Arg Ala           
            30                  35                  40                    

tcg tgc cgg ccg acc acg gct gcc cgg ggc cag ccc tct cgg cgc gtg        195
Ser Cys Arg Pro Thr Thr Ala Ala Arg Gly Gln Pro Ser Arg Arg Val           
        45                  50                  55                        

tcc aag ctg gcg tct ggg ccc ctg gcc gcc ccc gcg cag ccg cgc ccg        243
Ser Lys Leu Ala Ser Gly Pro Leu Ala Ala Pro Ala Gln Pro Arg Pro           
    60                  65                  70                            

ctc cgc agc ctc tcg ccg tcg gtt cgc cag ctc tcc cgg cgc ttc gac        291
Leu Arg Ser Leu Ser Pro Ser Val Arg Gln Leu Ser Arg Arg Phe Asp           
75                  80                  85                  90            

gcg ccg cgt ctg gac gac ggc tcc gct ggg acc cga gac gga ggc gtc        339
Ala Pro Arg Leu Asp Asp Gly Ser Ala Gly Thr Arg Asp Gly Gly Val           
                95                  100                 105               

tta ccc gcg gcc gcg gaa gaa gcg gcc gag ggc cca gcg cga gga gcc        387
Leu Pro Ala Ala Ala Glu Glu Ala Ala Glu Gly Pro Ala Arg Gly Ala           
            110                 115                 120                   

tgg ccc agc gtc acc gag atg cgc aag ctc ttc ggc ggt cct ggc tcc        435
Trp Pro Ser Val Thr Glu Met Arg Lys Leu Phe Gly Gly Pro Gly Ser           
        125                 130                 135                       

agg agg ccc agc gcc gac tct gaa tcc cca gga acg ccc agc ccc gac        483
Arg Arg Pro Ser Ala Asp Ser Glu Ser Pro Gly Thr Pro Ser Pro Asp           
    140                 145                 150                           

ggt gcc gcg tgg gag cct ccg gct cgg gag tcg cgg cag cca ccg acg        531
Gly Ala Ala Trp Glu Pro Pro Ala Arg Glu Ser Arg Gln Pro Pro Thr           
155                 160                 165                 170           

cca ccc cct cgg aca tgc ttc ccc ctg gcg ggt ctg cgt tcg gcg cgg        579
Pro Pro Pro Arg Thr Cys Phe Pro Leu Ala Gly Leu Arg Ser Ala Arg           
                175                 180                 185               

ccc ctg acc ggg ccg gag acc gaa ggg agg ctg cgc cgg ccg cag cag        627
Pro Leu Thr Gly Pro Glu Thr Glu Gly Arg Leu Arg Arg Pro Gln Gln           
            190                 195                 200                   

caa cag gag cgg gcg cag cgt cca gcg gat ggt tta cat tct tgg cat        675
Gln Gln Glu Arg Ala Gln Arg Pro Ala Asp Gly Leu His Ser Trp His           
        205                 210                 215                       

atc ttc tcc caa ccg cag gcc ggg gcc cgg gcc tcc tgc tcc tcc tcc        723
Ile Phe Ser Gln Pro Gln Ala Gly Ala Arg Ala Ser Cys Ser Ser Ser           
    220                 225                 230                           

tcc atc gcc gcc tcc tat cct gtc agc cgc agt cgt gct gcc agc tcc        771
Ser Ile Ala Ala Ser Tyr Pro Val Ser Arg Ser Arg Ala Ala Ser Ser           
235                 240                 245                 250           

agc gag gag gaa gag gag ggc ccg ccg cag ctg cct gga gcc cag agt        819
Ser Glu Glu Glu Glu Glu Gly Pro Pro Gln Leu Pro Gly Ala Gln Ser           
                255                 260                 265               

ccg gcc tac cac ggc ggc cac tcc tcg ggc agt gac gac gac cga gac        867
Pro Ala Tyr His Gly Gly His Ser Ser Gly Ser Asp Asp Asp Arg Asp           
            270                 275                 280                   

ggt gag ggc ggc cac cgc tgg gga ggg agg ccc ggg ctc agg cct gga        915
Gly Glu Gly Gly His Arg Trp Gly Gly Arg Pro Gly Leu Arg Pro Gly           
        285                 290                 295                       

agc tcc cta ttg gat cag gac tgc agg cct gac agt gat ggg tta aat        963
Ser Ser Leu Leu Asp Gln Asp Cys Arg Pro Asp Ser Asp Gly Leu Asn           
    300                 305                 310                           

cta agc agc atg aac tca gca ggg gtt tct ggg agc cct gag ccc cca       1011
Leu Ser Ser Met Asn Ser Ala Gly Val Ser Gly Ser Pro Glu Pro Pro           
315                 320                 325                 330           

aca tct cca aga gcc cct aga gaa gaa gga ctc cgg gag tgg ggt agt       1059
Thr Ser Pro Arg Ala Pro Arg Glu Glu Gly Leu Arg Glu Trp Gly Ser           
                335                 340                 345               

ggc tct ccg ccc tgc gtc cca ggt ccc cag gag gga ctt cgg cct atg       1107
Gly Ser Pro Pro Cys Val Pro Gly Pro Gln Glu Gly Leu Arg Pro Met           
            350                 355                 360                   

tct gac tct gtg gga gga gct ttc cgt gtg gcc aag gtg agc ttt ccc       1155
Ser Asp Ser Val Gly Gly Ala Phe Arg Val Ala Lys Val Ser Phe Pro           
        365                 370                 375                       

tcg tac ctg gcc agc ccc gca ggc tcc cgc ggt agc agc cgt tat tcc       1203
Ser Tyr Leu Ala Ser Pro Ala Gly Ser Arg Gly Ser Ser Arg Tyr Ser           
    380                 385                 390                           

agc acg gag acc ctc aag gac gac gac cta tgg tct agt agg ggt tct       1251
Ser Thr Glu Thr Leu Lys Asp Asp Asp Leu Trp Ser Ser Arg Gly Ser           
395                 400                 405                 410           

ggg ggc tgg ggc gtg tac cgc tcc cct agc ttt gga gct ggg gaa ggg       1299
Gly Gly Trp Gly Val Tyr Arg Ser Pro Ser Phe Gly Ala Gly Glu Gly           
                415                 420                 425               

ctc ctg cgg tcc cag gct cga acc cgt gcc aaa gga cct gga ggc acc       1347
Leu Leu Arg Ser Gln Ala Arg Thr Arg Ala Lys Gly Pro Gly Gly Thr           
            430                 435                 440                   

tct agg gca ttg agg gat gga gga ttt gag cct gaa aag agt cga cag       1395
Ser Arg Ala Leu Arg Asp Gly Gly Phe Glu Pro Glu Lys Ser Arg Gln           
        445                 450                 455                       

cgg aag tcc ctg tca aat cca gat atc gcc tca gag acc ctg acg ctt       1443
Arg Lys Ser Leu Ser Asn Pro Asp Ile Ala Ser Glu Thr Leu Thr Leu           
    460                 465                 470                           

ctc agt ttc ctg cgc tca gac ctt tca gag ctg agg gtc cga aaa cct       1491
Leu Ser Phe Leu Arg Ser Asp Leu Ser Glu Leu Arg Val Arg Lys Pro           
475                 480                 485                 490           

ggt ggg agc tcc ggg gac cgt gga agc aac ccc cta gat ggc aga gac       1539
Gly Gly Ser Ser Gly Asp Arg Gly Ser Asn Pro Leu Asp Gly Arg Asp           
                495                 500                 505               

tca cca tcc gca ggt ggc cct gtg ggg caa ctt gaa ccc ata ccc atc       1587
Ser Pro Ser Ala Gly Gly Pro Val Gly Gln Leu Glu Pro Ile Pro Ile           
            510                 515                 520                   

cca gcc cca gca tca cct ggc acg cgc ccc aca ctc aag gac ttg aca       1635
Pro Ala Pro Ala Ser Pro Gly Thr Arg Pro Thr Leu Lys Asp Leu Thr           
        525                 530                 535                       

gcc act ctg cgg aga gca aag tca ttc acc tgc tct gag aag ccc atg       1683
Ala Thr Leu Arg Arg Ala Lys Ser Phe Thr Cys Ser Glu Lys Pro Met           
    540                 545                 550                           

gcc cgc cgc ctg ccc cgc acc agt gct ctg aag tcc agc tcc tcc gag       1731
Ala Arg Arg Leu Pro Arg Thr Ser Ala Leu Lys Ser Ser Ser Ser Glu           
555                 560                 565                 570           

ctc ctg ctc aca ggc cct ggt gcc gag gag gat ccg ctg ccc ctc atc       1779
Leu Leu Leu Thr Gly Pro Gly Ala Glu Glu Asp Pro Leu Pro Leu Ile           
                575                 580                 585               

gtc cag gac caa tat gtg cag gag gcc cgc cag gtt ttt gag aag atc       1827
Val Gln Asp Gln Tyr Val Gln Glu Ala Arg Gln Val Phe Glu Lys Ile           
            590                 595                 600                   

cag cgc atg ggt gcc caa caa gat gat gga agc gat gcc ccc cct gga       1875
Gln Arg Met Gly Ala Gln Gln Asp Asp Gly Ser Asp Ala Pro Pro Gly           
        605                 610                 615                       

agc cct gac tgg gca ggg gat gtg acc cga ggg cag cgg tcc cag gag       1923
Ser Pro Asp Trp Ala Gly Asp Val Thr Arg Gly Gln Arg Ser Gln Glu           
    620                 625                 630                           

gag ctc tca ggc cct gag tcc agt ctg aca gat gaa ggc att ggg gca       1971
Glu Leu Ser Gly Pro Glu Ser Ser Leu Thr Asp Glu Gly Ile Gly Ala           
635                 640                 645                 650           

gac cct gag cct cct gtt gca gca ttt tgc ggc ctg ggt acc aca ggg       2019
Asp Pro Glu Pro Pro Val Ala Ala Phe Cys Gly Leu Gly Thr Thr Gly           
                655                 660                 665               

atg tgg cga cct ctt tcc tca tcc tcg gcc cag acg aac cac cat ggc       2067
Met Trp Arg Pro Leu Ser Ser Ser Ser Ala Gln Thr Asn His His Gly           
            670                 675                 680                   

cct ggg act gag gac agt ctg ggc ggg tgg gcc ctg gtg tcg cct gag       2115
Pro Gly Thr Glu Asp Ser Leu Gly Gly Trp Ala Leu Val Ser Pro Glu           
        685                 690                 695                       

acc cct ccc aca cca ggt gcc ctc cgc cga cga cgc aaa gtc cca cct       2163
Thr Pro Pro Thr Pro Gly Ala Leu Arg Arg Arg Arg Lys Val Pro Pro           
    700                 705                 710                           

tca ggt tct ggt ggg agc gaa ttg agc aat ggg gag gca ggg gag gcc       2211
Ser Gly Ser Gly Gly Ser Glu Leu Ser Asn Gly Glu Ala Gly Glu Ala           
715                 720                 725                 730           

tac agg tcc ctg agt gac cca att cct cag cgc cac cgg gct gcc acc       2259
Tyr Arg Ser Leu Ser Asp Pro Ile Pro Gln Arg His Arg Ala Ala Thr           
                735                 740                 745               

tct gaa gag cct act ggg ttc tct gtg gac agc aac ctc ctg ggc tca       2307
Ser Glu Glu Pro Thr Gly Phe Ser Val Asp Ser Asn Leu Leu Gly Ser           
            750                 755                 760                   

ctg agc ccc aag aca ggg ctc cct gcc acc tca gcc atg gat gag ggc       2355
Leu Ser Pro Lys Thr Gly Leu Pro Ala Thr Ser Ala Met Asp Glu Gly           
        765                 770                 775                       

ttg acc agt ggt cac agt gac tgg tct gtg ggc agt gaa gag agc aag       2403
Leu Thr Ser Gly His Ser Asp Trp Ser Val Gly Ser Glu Glu Ser Lys           
    780                 785                 790                           

gga tat cag gag gtt att cag agc ata gtt cag ggg cct ggc acc ctg       2451
Gly Tyr Gln Glu Val Ile Gln Ser Ile Val Gln Gly Pro Gly Thr Leu           
795                 800                 805                 810           

ggg cgt gtg gtg gac gac agg att gct ggc aaa gcc ccc aag aag aaa       2499
Gly Arg Val Val Asp Asp Arg Ile Ala Gly Lys Ala Pro Lys Lys Lys           
                815                 820                 825               

tcc ctg agt gac ccc agc cgc cgt ggg gag ctg gct ggg cct gga ttc       2547
Ser Leu Ser Asp Pro Ser Arg Arg Gly Glu Leu Ala Gly Pro Gly Phe           
            830                 835                 840                   

gag ggc cct gga ggg gag ccc atc cga gaa gtt gag ccc atg ctg cct       2595
Glu Gly Pro Gly Gly Glu Pro Ile Arg Glu Val Glu Pro Met Leu Pro           
        845                 850                 855                       

cca tcc agc agc gag ccc atc ctt gta gag cag cgg gca gag cca gaa       2643
Pro Ser Ser Ser Glu Pro Ile Leu Val Glu Gln Arg Ala Glu Pro Glu           
    860                 865                 870                           

gaa cct ggt gcc acc agg agc cgg gca cag tct gaa agg gcc cta cct       2691
Glu Pro Gly Ala Thr Arg Ser Arg Ala Gln Ser Glu Arg Ala Leu Pro           
875                 880                 885                 890           

gag gct ctg cct ccc cct gcc act gcc cac cga aac ttt cac ctt gac       2739
Glu Ala Leu Pro Pro Pro Ala Thr Ala His Arg Asn Phe His Leu Asp           
                895                 900                 905               

ccc aag ctg gct gac att ctg tcc ccg agg cta atc cgc cga ggc tcc       2787
Pro Lys Leu Ala Asp Ile Leu Ser Pro Arg Leu Ile Arg Arg Gly Ser           
            910                 915                 920                   

aag aag cgc cca gct cgg agt agt cac cag gag ctt cgg aga gac gag       2835
Lys Lys Arg Pro Ala Arg Ser Ser His Gln Glu Leu Arg Arg Asp Glu           
        925                 930                 935                       

ggc agt cag gac cag act ggc agc ctg tct cgg gcc cgg ccc tcc tcc       2883
Gly Ser Gln Asp Gln Thr Gly Ser Leu Ser Arg Ala Arg Pro Ser Ser           
    940                 945                 950                           

aga cac gtt cgc cat gcc agt gtg ccc gcc aca ttt atg cct att gtg       2931
Arg His Val Arg His Ala Ser Val Pro Ala Thr Phe Met Pro Ile Val           
955                 960                 965                 970           

gtg cct gag cca cca act tct gtt ggt ccc cct gtg gct gtg cca gaa       2979
Val Pro Glu Pro Pro Thr Ser Val Gly Pro Pro Val Ala Val Pro Glu           
                975                 980                 985               

ccc ata ggc ttc cct acc cga gcc cat ccc acg ttg cag gca  cca tcg      3027
Pro Ile Gly Phe Pro Thr Arg Ala His Pro Thr Leu Gln Ala  Pro Ser          
            990                 995                 1000                  

ctc gag gac  gtc acc aag cag tac  atg ctg aac ctg cac  tcc ggt        3072
Leu Glu Asp  Val Thr Lys Gln Tyr  Met Leu Asn Leu His  Ser Gly            
        1005                 1010                 1015                    

gag gtc cct  gcc cca gtg cca gtg  gac atg ccc tgc ttg  cct ctg        3117
Glu Val Pro  Ala Pro Val Pro Val  Asp Met Pro Cys Leu  Pro Leu            
        1020                 1025                 1030                    

gct gca ccg  ccc tct gct gag gcc  aag ccc cct gag gca  gct cgg        3162
Ala Ala Pro  Pro Ser Ala Glu Ala  Lys Pro Pro Glu Ala  Ala Arg            
        1035                 1040                 1045                    

cct gca gat  gag cct acc cct gcc  agc aag tgc tgc agc  aag cca        3207
Pro Ala Asp  Glu Pro Thr Pro Ala  Ser Lys Cys Cys Ser  Lys Pro            
        1050                 1055                 1060                    

cag gtg gac  atg cgg aag cac gtg  gcc atg acc ctg ctg  gac aca        3252
Gln Val Asp  Met Arg Lys His Val  Ala Met Thr Leu Leu  Asp Thr            
        1065                 1070                 1075                    

gag cag tcg  tat gtg gag tcg ctg  cgc acc ctg atg cag  ggc tac        3297
Glu Gln Ser  Tyr Val Glu Ser Leu  Arg Thr Leu Met Gln  Gly Tyr            
        1080                 1085                 1090                    

atg cag ccg  ctg aag cag cca gag  aac tcc gtg ctc tgt  gac cct        3342
Met Gln Pro  Leu Lys Gln Pro Glu  Asn Ser Val Leu Cys  Asp Pro            
        1095                 1100                 1105                    

tca ctg gtg  gac gag atc ttc gac  cag atc ccc gag ctc  ctg gag        3387
Ser Leu Val  Asp Glu Ile Phe Asp  Gln Ile Pro Glu Leu  Leu Glu            
        1110                 1115                 1120                    

cac cac gag  caa ttc ctg gag cag  gtt cgg cac tgc atg  cag acc        3432
His His Glu  Gln Phe Leu Glu Gln  Val Arg His Cys Met  Gln Thr            
        1125                 1130                 1135                    

tgg cat gcc  cag cag aag gtg gga  gcc ctg ctc gtc cag  tcg ttc        3477
Trp His Ala  Gln Gln Lys Val Gly  Ala Leu Leu Val Gln  Ser Phe            
        1140                 1145                 1150                    

tcc aag gat  gtc cta gta aac atc  tat tct gcc tat atc  gat aac        3522
Ser Lys Asp  Val Leu Val Asn Ile  Tyr Ser Ala Tyr Ile  Asp Asn            
        1155                 1160                 1165                    

ttc ctc aat  gca aag gat gct gtg  cgt gtg gcc aag gag  gcg agg        3567
Phe Leu Asn  Ala Lys Asp Ala Val  Arg Val Ala Lys Glu  Ala Arg            
        1170                 1175                 1180                    

cct gcc ttt  ctc aag ttc cta gag  caa agc atg cgt gag  aac aag        3612
Pro Ala Phe  Leu Lys Phe Leu Glu  Gln Ser Met Arg Glu  Asn Lys            
        1185                 1190                 1195                    

gag aag cag  gcg ctg tct gac ctc  atg atc aag cct gtg  cag cgg        3657
Glu Lys Gln  Ala Leu Ser Asp Leu  Met Ile Lys Pro Val  Gln Arg            
        1200                 1205                 1210                    

atc cca cgc  tac gag ctt ctg gtg  aag gac ctc ctg aag  cat aca        3702
Ile Pro Arg  Tyr Glu Leu Leu Val  Lys Asp Leu Leu Lys  His Thr            
        1215                 1220                 1225                    

cct gag gac  cac ccg gac cat cca  ctc ctg ctg gag gcg  cag cgg        3747
Pro Glu Asp  His Pro Asp His Pro  Leu Leu Leu Glu Ala  Gln Arg            
        1230                 1235                 1240                    

aac atc aag  cag gtg gct gag cgc  atc aac aag ggt gtg  cgg agt        3792
Asn Ile Lys  Gln Val Ala Glu Arg  Ile Asn Lys Gly Val  Arg Ser            
        1245                 1250                 1255                    

gcc gag gag  gcg gag cgc cat gcc  cgt gtg ctg cag gag  ata gag        3837
Ala Glu Glu  Ala Glu Arg His Ala  Arg Val Leu Gln Glu  Ile Glu            
        1260                 1265                 1270                    

gct cac atc  gag ggc atg gag gat  ctc cag gcc cct ctg  cgg cgg        3882
Ala His Ile  Glu Gly Met Glu Asp  Leu Gln Ala Pro Leu  Arg Arg            
        1275                 1280                 1285                    

ttc ctg aga  cag gag atg gtc att  gaa gtg aag gcg atc  ggt ggc        3927
Phe Leu Arg  Gln Glu Met Val Ile  Glu Val Lys Ala Ile  Gly Gly            
        1290                 1295                 1300                    

aag aag gac  cgg tct ctc ttc ctg  ttc acg gac ctc atc  gtc tgc        3972
Lys Lys Asp  Arg Ser Leu Phe Leu  Phe Thr Asp Leu Ile  Val Cys            
        1305                 1310                 1315                    

acc act ctg  aag cga aag tca ggc  tcc ctg cgg cgc agc  tcc atg        4017
Thr Thr Leu  Lys Arg Lys Ser Gly  Ser Leu Arg Arg Ser  Ser Met            
        1320                 1325                 1330                    

agc ctg tac  acg gca gcc agt gtc  att gac aca gcc agc  aag tac        4062
Ser Leu Tyr  Thr Ala Ala Ser Val  Ile Asp Thr Ala Ser  Lys Tyr            
        1335                 1340                 1345                    

aag atg ctg  tgg aag ctg ccg ctg  gaa gac gca gac atc  atc aaa        4107
Lys Met Leu  Trp Lys Leu Pro Leu  Glu Asp Ala Asp Ile  Ile Lys            
        1350                 1355                 1360                    

ggg gca tcc  caa gcc acc aat cgg  gag aac atc cag aag  gcc atc        4152
Gly Ala Ser  Gln Ala Thr Asn Arg  Glu Asn Ile Gln Lys  Ala Ile            
        1365                 1370                 1375                    

agc cgc ctt  gat gag gac ctc acc  acc ctg ggc caa atg  agc aag        4197
Ser Arg Leu  Asp Glu Asp Leu Thr  Thr Leu Gly Gln Met  Ser Lys            
        1380                 1385                 1390                    

ctc tct gag  agc ctt ggt ttc ccc  cac cag agc ctg gac  gat gca        4242
Leu Ser Glu  Ser Leu Gly Phe Pro  His Gln Ser Leu Asp  Asp Ala            
        1395                 1400                 1405                    

ctg cgg gac  ctc tca gct gcc atg  cac cgg gac ctg tcg  gag aag        4287
Leu Arg Asp  Leu Ser Ala Ala Met  His Arg Asp Leu Ser  Glu Lys            
        1410                 1415                 1420                    

cag gcg ctg  tgc tac gcg ctt tcc  ttc ccg cca acc aag  ctg gag        4332
Gln Ala Leu  Cys Tyr Ala Leu Ser  Phe Pro Pro Thr Lys  Leu Glu            
        1425                 1430                 1435                    

ctg tgc gcc  act cgg ccc gag ggc  acc gac tcc tac att  ttt gag        4377
Leu Cys Ala  Thr Arg Pro Glu Gly  Thr Asp Ser Tyr Ile  Phe Glu            
        1440                 1445                 1450                    

ttc cct cac  cct gac gcc cgc ctt  ggt ttt gaa cag gcc  ttc gat        4422
Phe Pro His  Pro Asp Ala Arg Leu  Gly Phe Glu Gln Ala  Phe Asp            
        1455                 1460                 1465                    

gag gcc aag  agg aag ctg gca tcc  agc aaa agc tgt cta  gac cct        4467
Glu Ala Lys  Arg Lys Leu Ala Ser  Ser Lys Ser Cys Leu  Asp Pro            
        1470                 1475                 1480                    

gag ttc ctg  aag gcc atc ccc atc  atg aaa acc cgc agt  ggc atg        4512
Glu Phe Leu  Lys Ala Ile Pro Ile  Met Lys Thr Arg Ser  Gly Met            
        1485                 1490                 1495                    

cag ttc tcc  tgt gcg gct ccc acc  ctg aac agc tgc ccg  gag ccc        4557
Gln Phe Ser  Cys Ala Ala Pro Thr  Leu Asn Ser Cys Pro  Glu Pro            
        1500                 1505                 1510                    

tcg cct gag  gta tgg gtc tgc aac  agc gac ggc tac gtg  ggc cag        4602
Ser Pro Glu  Val Trp Val Cys Asn  Ser Asp Gly Tyr Val  Gly Gln            
        1515                 1520                 1525                    

gtg tgc ctg  ctg agc ctg cgc gcc  gag ccg gac gtg gag  gcc tgc        4647
Val Cys Leu  Leu Ser Leu Arg Ala  Glu Pro Asp Val Glu  Ala Cys            
        1530                 1535                 1540                    

atc gcc gtc  tgt tcc gcc cgc atc  ctc tgc atc ggg gcg  gtg ccc        4692
Ile Ala Val  Cys Ser Ala Arg Ile  Leu Cys Ile Gly Ala  Val Pro            
        1545                 1550                 1555                    

ggg ctg cag  cct cgc tgc cac cgg  gag cct cct ccg tcg  ctg agg        4737
Gly Leu Gln  Pro Arg Cys His Arg  Glu Pro Pro Pro Ser  Leu Arg            
        1560                 1565                 1570                    

agt cct cca  gag acg gca ccg gag  ccc gcc ggg ccg gag  ctg gac        4782
Ser Pro Pro  Glu Thr Ala Pro Glu  Pro Ala Gly Pro Glu  Leu Asp            
        1575                 1580                 1585                    

gtc gag gcc  gct gca gac gag gaa  gcc gcg acg ctc gcg  gag ccg        4827
Val Glu Ala  Ala Ala Asp Glu Glu  Ala Ala Thr Leu Ala  Glu Pro            
        1590                 1595                 1600                    

ggg ccg cag  ccc tgc ctt cac atc  tcc att gca ggc tcg  ggc ttg        4872
Gly Pro Gln  Pro Cys Leu His Ile  Ser Ile Ala Gly Ser  Gly Leu            
        1605                 1610                 1615                    

gag atg acg  ccg ggc ctc ggc gag  ggt gac ccc cgc cca  gag ctg        4917
Glu Met Thr  Pro Gly Leu Gly Glu  Gly Asp Pro Arg Pro  Glu Leu            
        1620                 1625                 1630                    

gtg ccc ttt  gac agt gac tct gac  gat gag tct tcg ccc  agc ccc        4962
Val Pro Phe  Asp Ser Asp Ser Asp  Asp Glu Ser Ser Pro  Ser Pro            
        1635                 1640                 1645                    

tcg ggg acg  ctg cag agc cag gcc  agc cgg tcc acc atc  tcc tcc        5007
Ser Gly Thr  Leu Gln Ser Gln Ala  Ser Arg Ser Thr Ile  Ser Ser            
        1650                 1655                 1660                    

agc ttt ggc  aat gag gag acc ccg  agt tcc aag gag gcc  acg gca        5052
Ser Phe Gly  Asn Glu Glu Thr Pro  Ser Ser Lys Glu Ala  Thr Ala            
        1665                 1670                 1675                    

gag acc acc  agc tca gag gag gag  cag gag cca ggc ttc  ctg cca        5097
Glu Thr Thr  Ser Ser Glu Glu Glu  Gln Glu Pro Gly Phe  Leu Pro            
        1680                 1685                 1690                    

ctg tct ggc  tcc ttt ggg cct ggt  ggt ccc tgc ggc acc  agc cca        5142
Leu Ser Gly  Ser Phe Gly Pro Gly  Gly Pro Cys Gly Thr  Ser Pro            
        1695                 1700                 1705                    

atg gat ggg  aga gcc ctt cgc cgc  tcc agc cac ggc tcc  ttc acc        5187
Met Asp Gly  Arg Ala Leu Arg Arg  Ser Ser His Gly Ser  Phe Thr            
        1710                 1715                 1720                    

cgg ggc agc  ctt gag gac ctg ctg  agt gtc gac cct gag  gcc tac        5232
Arg Gly Ser  Leu Glu Asp Leu Leu  Ser Val Asp Pro Glu  Ala Tyr            
        1725                 1730                 1735                    

cag agc tcc  gtg tgg ctg ggc act  gag gat ggc tgt gtc  cac gtg        5277
Gln Ser Ser  Val Trp Leu Gly Thr  Glu Asp Gly Cys Val  His Val            
        1740                 1745                 1750                    

tac cag tcc  tcc gac agc atc cgt  gac cgc agg aac agc  atg aag        5322
Tyr Gln Ser  Ser Asp Ser Ile Arg  Asp Arg Arg Asn Ser  Met Lys            
        1755                 1760                 1765                    

ctc cag cat  gcg gcc tct gtg acc  tgc atc ttg tat ctg  aat aac        5367
Leu Gln His  Ala Ala Ser Val Thr  Cys Ile Leu Tyr Leu  Asn Asn            
        1770                 1775                 1780                    

cag gtg ttt  gtg tct ctg gcc aat  gga gag ctt gtg gtc  tac caa        5412
Gln Val Phe  Val Ser Leu Ala Asn  Gly Glu Leu Val Val  Tyr Gln            
        1785                 1790                 1795                    

agg gaa gca  ggc cat ttc tgg gac  ccc cag aac ttc aaa  tca gtg        5457
Arg Glu Ala  Gly His Phe Trp Asp  Pro Gln Asn Phe Lys  Ser Val            
        1800                 1805                 1810                    

acc ttg ggc  acc cag ggg agc ccc  atc acc aag atg gta  tct gtg        5502
Thr Leu Gly  Thr Gln Gly Ser Pro  Ile Thr Lys Met Val  Ser Val            
        1815                 1820                 1825                    

ggt ggg cgg  ctg tgg tgt ggc tgc  cag aac cga gtc ctt  gtc ctg        5547
Gly Gly Arg  Leu Trp Cys Gly Cys  Gln Asn Arg Val Leu  Val Leu            
        1830                 1835                 1840                    

agc cct gac  acg ctg cag ctg gag  cac atg ttt tac gtg  ggt cag        5592
Ser Pro Asp  Thr Leu Gln Leu Glu  His Met Phe Tyr Val  Gly Gln            
        1845                 1850                 1855                    

gat tca agc  cgc tgc gtg gct tgc  atg gtg gac tcc agc  ctg ggt        5637
Asp Ser Ser  Arg Cys Val Ala Cys  Met Val Asp Ser Ser  Leu Gly            
        1860                 1865                 1870                    

gtg tgg gtg  aca ttg aaa ggt agt  gcc cac gtg tgt ctc  tac cat        5682
Val Trp Val  Thr Leu Lys Gly Ser  Ala His Val Cys Leu  Tyr His            
        1875                 1880                 1885                    

cca gac acc  ttt gag cag ctg gca  gaa gta gac gtc act  cct ccc        5727
Pro Asp Thr  Phe Glu Gln Leu Ala  Glu Val Asp Val Thr  Pro Pro            
        1890                 1895                 1900                    

gtg cac agg  atg ctg gca ggc tcg  gat gcc atc atc cgg  cag cac        5772
Val His Arg  Met Leu Ala Gly Ser  Asp Ala Ile Ile Arg  Gln His            
        1905                 1910                 1915                    

aag gct gcc  tgt ctg cga atc aca  gcg ctg ctg gtg tgt  gag gag        5817
Lys Ala Ala  Cys Leu Arg Ile Thr  Ala Leu Leu Val Cys  Glu Glu            
        1920                 1925                 1930                    

ctg ctg tgg  gtg ggc acc agt gct  ggt gtc gtc ctc acc  atg ccc        5862
Leu Leu Trp  Val Gly Thr Ser Ala  Gly Val Val Leu Thr  Met Pro            
        1935                 1940                 1945                    

act tcg ccc  ggt act gtc agc tgc  cca cgg gca cca ctc  agt ccc        5907
Thr Ser Pro  Gly Thr Val Ser Cys  Pro Arg Ala Pro Leu  Ser Pro            
        1950                 1955                 1960                    

aca ggc ctc  ggc cag gga cac acc  ggc cac gtc cgc ttc  ttg gct        5952
Thr Gly Leu  Gly Gln Gly His Thr  Gly His Val Arg Phe  Leu Ala            
        1965                 1970                 1975                    

gca gtc cag  ctg cca gat ggc ttc  aac ctg ctc tgc cca  acc cca        5997
Ala Val Gln  Leu Pro Asp Gly Phe  Asn Leu Leu Cys Pro  Thr Pro            
        1980                 1985                 1990                    

cca cct ccc  cca gac aca ggc ccc  gag aag ctg cca tca  ctg gag        6042
Pro Pro Pro  Pro Asp Thr Gly Pro  Glu Lys Leu Pro Ser  Leu Glu            
        1995                 2000                 2005                    

cac cgg gac  tcc cct tgg cac cga  ggc ccc gcc cct gcc  agg cct        6087
His Arg Asp  Ser Pro Trp His Arg  Gly Pro Ala Pro Ala  Arg Pro            
        2010                 2015                 2020                    

aaa atg ctg  gtt atc agt gga ggt  gat ggc tat gag gac  ttc cga        6132
Lys Met Leu  Val Ile Ser Gly Gly  Asp Gly Tyr Glu Asp  Phe Arg            
        2025                 2030                 2035                    

ctc agc agt  ggg ggc ggc agc agc  agt gag act gtg ggt  cga gac        6177
Leu Ser Ser  Gly Gly Gly Ser Ser  Ser Glu Thr Val Gly  Arg Asp            
        2040                 2045                 2050                    

gac agc aca  aac cac ctc ctc ctg  tgg agg gtg tga ccctgtctgc          6223
Asp Ser Thr  Asn His Leu Leu Leu  Trp Arg Val                             
        2055                 2060                                         

cgtggcccag gactcgcccg cccacctgcc ttcagcctgc ttgcctctcc ctagcccaca     6283

cgcagacttt gaccaggagt atccagccag gggcacacat gtgcctgcgt gggctctgcc     6343

ttgtcttcgc ggaagcattc ctgatggaac acccactggc cagccaggcc atggcttctc     6403

ccgaccctct ggctgccccg gtgcttccag tcatgatcgg gtgggggaca tgtgggctga     6463

ccaggacctc tgaccctgga gcttctacca aagacacagc tgggtctgga ccccacgggg     6523

ctggggaggg ccatgtgcaa tatttggagg gttttctgga gggcagcagg aaggctgggg     6583

aattccccat gtacagtatt tatgtttctt tttagatgtg taccttccca agcacttatt     6643

tatgcagtga cctggtcacc tggggtgggg gtgatttgag gaaatgacat gaggaaaaga     6703

aacctattcc tgccctgggg accaccctgg gactctaacc aagccttcct ggagggaccc     6763

atgcgcccct gagccccatt ccattcatac agacacacac gtacgcacac tgcatgtcca     6823

aggccctaaa cattgcccgt tgacataaac tttccagggc cccagcctga tggggctgcc     6883

ctcagtcctc tagatcaaga tgctgactat tagggggcag tgattgccat ctggggacct     6943

gtcaggcttt gtcatttccc agtttgttgg tggtgccttt agtggttccc taatttggga     7003

acactgatgg ggccttggac agggctttct ctcaggtagg agaaatgggc ccatgatctc     7063

ctcacagtcg cccccagtcc ttggccctgc ttccctgtgt ctcatgcact ggcacatatg     7123

gtcaccttgg agggcagacc taggagcccc tctgaccact gaatccgtct ccacacccct     7183

tctgccaagg gaagcccctt caggaaggac cccccaaagc tgaggggctg aatgtagcct     7243

tttcaacaga gaaggctccc acttgagagc agcctctacc tgaccccctg gaccacagag     7303

agccactctg accctcagcc ccctcgcttc ttcagctaaa actccaaagg tttggtttca     7363

gatggggttt gttttgttct gtttggtttt ggttttgttt ggggtgggtg ggtcattgcg     7423

gtcttagatt atgtttctct tgctaccaaa cagtcatgta ttaactctct ttggatgatg     7483

aagtttaaag agtcaataaa tagaaacacc agatgactgc attggtggcc acagtggcct     7543

cctgtcagca acctcagggc tcagtctccc tggccacatg ggccttccga cgtccacaca     7603

cttgggaaga agggaggcct tggagaccca gaagagtgct ggacggcgag gttgccacga     7663

tttgctgtgt tacctgggca ggtggctggg ctgcagtttc ctcatcagga aaataaaggg     7723

gttgtaccag ttcagtgctt tgtaaccagg gttacatggt agaatccctt gcagatgaca     7783

tgtaaatgca gaaacatgat tcgtaactta aaaaaaaaaa aaaaaaa                   7830


<210>  48
<211>  2063
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Asp Gly Ala Pro Arg Pro Gln Leu Tyr Arg Ser Val Ser Phe 
1               5                   10                  15      


Lys Leu Leu Glu Arg Trp Ser Gly Gly Pro Gly Leu Arg Glu Glu Asp 
            20                  25                  30          


Thr Asp Thr Pro Gly Leu Arg Arg Arg Ala Ser Cys Arg Pro Thr Thr 
        35                  40                  45              


Ala Ala Arg Gly Gln Pro Ser Arg Arg Val Ser Lys Leu Ala Ser Gly 
    50                  55                  60                  


Pro Leu Ala Ala Pro Ala Gln Pro Arg Pro Leu Arg Ser Leu Ser Pro 
65                  70                  75                  80  


Ser Val Arg Gln Leu Ser Arg Arg Phe Asp Ala Pro Arg Leu Asp Asp 
                85                  90                  95      


Gly Ser Ala Gly Thr Arg Asp Gly Gly Val Leu Pro Ala Ala Ala Glu 
            100                 105                 110         


Glu Ala Ala Glu Gly Pro Ala Arg Gly Ala Trp Pro Ser Val Thr Glu 
        115                 120                 125             


Met Arg Lys Leu Phe Gly Gly Pro Gly Ser Arg Arg Pro Ser Ala Asp 
    130                 135                 140                 


Ser Glu Ser Pro Gly Thr Pro Ser Pro Asp Gly Ala Ala Trp Glu Pro 
145                 150                 155                 160 


Pro Ala Arg Glu Ser Arg Gln Pro Pro Thr Pro Pro Pro Arg Thr Cys 
                165                 170                 175     


Phe Pro Leu Ala Gly Leu Arg Ser Ala Arg Pro Leu Thr Gly Pro Glu 
            180                 185                 190         


Thr Glu Gly Arg Leu Arg Arg Pro Gln Gln Gln Gln Glu Arg Ala Gln 
        195                 200                 205             


Arg Pro Ala Asp Gly Leu His Ser Trp His Ile Phe Ser Gln Pro Gln 
    210                 215                 220                 


Ala Gly Ala Arg Ala Ser Cys Ser Ser Ser Ser Ile Ala Ala Ser Tyr 
225                 230                 235                 240 


Pro Val Ser Arg Ser Arg Ala Ala Ser Ser Ser Glu Glu Glu Glu Glu 
                245                 250                 255     


Gly Pro Pro Gln Leu Pro Gly Ala Gln Ser Pro Ala Tyr His Gly Gly 
            260                 265                 270         


His Ser Ser Gly Ser Asp Asp Asp Arg Asp Gly Glu Gly Gly His Arg 
        275                 280                 285             


Trp Gly Gly Arg Pro Gly Leu Arg Pro Gly Ser Ser Leu Leu Asp Gln 
    290                 295                 300                 


Asp Cys Arg Pro Asp Ser Asp Gly Leu Asn Leu Ser Ser Met Asn Ser 
305                 310                 315                 320 


Ala Gly Val Ser Gly Ser Pro Glu Pro Pro Thr Ser Pro Arg Ala Pro 
                325                 330                 335     


Arg Glu Glu Gly Leu Arg Glu Trp Gly Ser Gly Ser Pro Pro Cys Val 
            340                 345                 350         


Pro Gly Pro Gln Glu Gly Leu Arg Pro Met Ser Asp Ser Val Gly Gly 
        355                 360                 365             


Ala Phe Arg Val Ala Lys Val Ser Phe Pro Ser Tyr Leu Ala Ser Pro 
    370                 375                 380                 


Ala Gly Ser Arg Gly Ser Ser Arg Tyr Ser Ser Thr Glu Thr Leu Lys 
385                 390                 395                 400 


Asp Asp Asp Leu Trp Ser Ser Arg Gly Ser Gly Gly Trp Gly Val Tyr 
                405                 410                 415     


Arg Ser Pro Ser Phe Gly Ala Gly Glu Gly Leu Leu Arg Ser Gln Ala 
            420                 425                 430         


Arg Thr Arg Ala Lys Gly Pro Gly Gly Thr Ser Arg Ala Leu Arg Asp 
        435                 440                 445             


Gly Gly Phe Glu Pro Glu Lys Ser Arg Gln Arg Lys Ser Leu Ser Asn 
    450                 455                 460                 


Pro Asp Ile Ala Ser Glu Thr Leu Thr Leu Leu Ser Phe Leu Arg Ser 
465                 470                 475                 480 


Asp Leu Ser Glu Leu Arg Val Arg Lys Pro Gly Gly Ser Ser Gly Asp 
                485                 490                 495     


Arg Gly Ser Asn Pro Leu Asp Gly Arg Asp Ser Pro Ser Ala Gly Gly 
            500                 505                 510         


Pro Val Gly Gln Leu Glu Pro Ile Pro Ile Pro Ala Pro Ala Ser Pro 
        515                 520                 525             


Gly Thr Arg Pro Thr Leu Lys Asp Leu Thr Ala Thr Leu Arg Arg Ala 
    530                 535                 540                 


Lys Ser Phe Thr Cys Ser Glu Lys Pro Met Ala Arg Arg Leu Pro Arg 
545                 550                 555                 560 


Thr Ser Ala Leu Lys Ser Ser Ser Ser Glu Leu Leu Leu Thr Gly Pro 
                565                 570                 575     


Gly Ala Glu Glu Asp Pro Leu Pro Leu Ile Val Gln Asp Gln Tyr Val 
            580                 585                 590         


Gln Glu Ala Arg Gln Val Phe Glu Lys Ile Gln Arg Met Gly Ala Gln 
        595                 600                 605             


Gln Asp Asp Gly Ser Asp Ala Pro Pro Gly Ser Pro Asp Trp Ala Gly 
    610                 615                 620                 


Asp Val Thr Arg Gly Gln Arg Ser Gln Glu Glu Leu Ser Gly Pro Glu 
625                 630                 635                 640 


Ser Ser Leu Thr Asp Glu Gly Ile Gly Ala Asp Pro Glu Pro Pro Val 
                645                 650                 655     


Ala Ala Phe Cys Gly Leu Gly Thr Thr Gly Met Trp Arg Pro Leu Ser 
            660                 665                 670         


Ser Ser Ser Ala Gln Thr Asn His His Gly Pro Gly Thr Glu Asp Ser 
        675                 680                 685             


Leu Gly Gly Trp Ala Leu Val Ser Pro Glu Thr Pro Pro Thr Pro Gly 
    690                 695                 700                 


Ala Leu Arg Arg Arg Arg Lys Val Pro Pro Ser Gly Ser Gly Gly Ser 
705                 710                 715                 720 


Glu Leu Ser Asn Gly Glu Ala Gly Glu Ala Tyr Arg Ser Leu Ser Asp 
                725                 730                 735     


Pro Ile Pro Gln Arg His Arg Ala Ala Thr Ser Glu Glu Pro Thr Gly 
            740                 745                 750         


Phe Ser Val Asp Ser Asn Leu Leu Gly Ser Leu Ser Pro Lys Thr Gly 
        755                 760                 765             


Leu Pro Ala Thr Ser Ala Met Asp Glu Gly Leu Thr Ser Gly His Ser 
    770                 775                 780                 


Asp Trp Ser Val Gly Ser Glu Glu Ser Lys Gly Tyr Gln Glu Val Ile 
785                 790                 795                 800 


Gln Ser Ile Val Gln Gly Pro Gly Thr Leu Gly Arg Val Val Asp Asp 
                805                 810                 815     


Arg Ile Ala Gly Lys Ala Pro Lys Lys Lys Ser Leu Ser Asp Pro Ser 
            820                 825                 830         


Arg Arg Gly Glu Leu Ala Gly Pro Gly Phe Glu Gly Pro Gly Gly Glu 
        835                 840                 845             


Pro Ile Arg Glu Val Glu Pro Met Leu Pro Pro Ser Ser Ser Glu Pro 
    850                 855                 860                 


Ile Leu Val Glu Gln Arg Ala Glu Pro Glu Glu Pro Gly Ala Thr Arg 
865                 870                 875                 880 


Ser Arg Ala Gln Ser Glu Arg Ala Leu Pro Glu Ala Leu Pro Pro Pro 
                885                 890                 895     


Ala Thr Ala His Arg Asn Phe His Leu Asp Pro Lys Leu Ala Asp Ile 
            900                 905                 910         


Leu Ser Pro Arg Leu Ile Arg Arg Gly Ser Lys Lys Arg Pro Ala Arg 
        915                 920                 925             


Ser Ser His Gln Glu Leu Arg Arg Asp Glu Gly Ser Gln Asp Gln Thr 
    930                 935                 940                 


Gly Ser Leu Ser Arg Ala Arg Pro Ser Ser Arg His Val Arg His Ala 
945                 950                 955                 960 


Ser Val Pro Ala Thr Phe Met Pro Ile Val Val Pro Glu Pro Pro Thr 
                965                 970                 975     


Ser Val Gly Pro Pro Val Ala Val Pro Glu Pro Ile Gly Phe Pro Thr 
            980                 985                 990         


Arg Ala His Pro Thr Leu Gln Ala  Pro Ser Leu Glu Asp  Val Thr Lys 
        995                 1000                 1005             


Gln Tyr  Met Leu Asn Leu His  Ser Gly Glu Val Pro  Ala Pro Val 
    1010                 1015                 1020             


Pro Val  Asp Met Pro Cys Leu  Pro Leu Ala Ala Pro  Pro Ser Ala 
    1025                 1030                 1035             


Glu Ala  Lys Pro Pro Glu Ala  Ala Arg Pro Ala Asp  Glu Pro Thr 
    1040                 1045                 1050             


Pro Ala  Ser Lys Cys Cys Ser  Lys Pro Gln Val Asp  Met Arg Lys 
    1055                 1060                 1065             


His Val  Ala Met Thr Leu Leu  Asp Thr Glu Gln Ser  Tyr Val Glu 
    1070                 1075                 1080             


Ser Leu  Arg Thr Leu Met Gln  Gly Tyr Met Gln Pro  Leu Lys Gln 
    1085                 1090                 1095             


Pro Glu  Asn Ser Val Leu Cys  Asp Pro Ser Leu Val  Asp Glu Ile 
    1100                 1105                 1110             


Phe Asp  Gln Ile Pro Glu Leu  Leu Glu His His Glu  Gln Phe Leu 
    1115                 1120                 1125             


Glu Gln  Val Arg His Cys Met  Gln Thr Trp His Ala  Gln Gln Lys 
    1130                 1135                 1140             


Val Gly  Ala Leu Leu Val Gln  Ser Phe Ser Lys Asp  Val Leu Val 
    1145                 1150                 1155             


Asn Ile  Tyr Ser Ala Tyr Ile  Asp Asn Phe Leu Asn  Ala Lys Asp 
    1160                 1165                 1170             


Ala Val  Arg Val Ala Lys Glu  Ala Arg Pro Ala Phe  Leu Lys Phe 
    1175                 1180                 1185             


Leu Glu  Gln Ser Met Arg Glu  Asn Lys Glu Lys Gln  Ala Leu Ser 
    1190                 1195                 1200             


Asp Leu  Met Ile Lys Pro Val  Gln Arg Ile Pro Arg  Tyr Glu Leu 
    1205                 1210                 1215             


Leu Val  Lys Asp Leu Leu Lys  His Thr Pro Glu Asp  His Pro Asp 
    1220                 1225                 1230             


His Pro  Leu Leu Leu Glu Ala  Gln Arg Asn Ile Lys  Gln Val Ala 
    1235                 1240                 1245             


Glu Arg  Ile Asn Lys Gly Val  Arg Ser Ala Glu Glu  Ala Glu Arg 
    1250                 1255                 1260             


His Ala  Arg Val Leu Gln Glu  Ile Glu Ala His Ile  Glu Gly Met 
    1265                 1270                 1275             


Glu Asp  Leu Gln Ala Pro Leu  Arg Arg Phe Leu Arg  Gln Glu Met 
    1280                 1285                 1290             


Val Ile  Glu Val Lys Ala Ile  Gly Gly Lys Lys Asp  Arg Ser Leu 
    1295                 1300                 1305             


Phe Leu  Phe Thr Asp Leu Ile  Val Cys Thr Thr Leu  Lys Arg Lys 
    1310                 1315                 1320             


Ser Gly  Ser Leu Arg Arg Ser  Ser Met Ser Leu Tyr  Thr Ala Ala 
    1325                 1330                 1335             


Ser Val  Ile Asp Thr Ala Ser  Lys Tyr Lys Met Leu  Trp Lys Leu 
    1340                 1345                 1350             


Pro Leu  Glu Asp Ala Asp Ile  Ile Lys Gly Ala Ser  Gln Ala Thr 
    1355                 1360                 1365             


Asn Arg  Glu Asn Ile Gln Lys  Ala Ile Ser Arg Leu  Asp Glu Asp 
    1370                 1375                 1380             


Leu Thr  Thr Leu Gly Gln Met  Ser Lys Leu Ser Glu  Ser Leu Gly 
    1385                 1390                 1395             


Phe Pro  His Gln Ser Leu Asp  Asp Ala Leu Arg Asp  Leu Ser Ala 
    1400                 1405                 1410             


Ala Met  His Arg Asp Leu Ser  Glu Lys Gln Ala Leu  Cys Tyr Ala 
    1415                 1420                 1425             


Leu Ser  Phe Pro Pro Thr Lys  Leu Glu Leu Cys Ala  Thr Arg Pro 
    1430                 1435                 1440             


Glu Gly  Thr Asp Ser Tyr Ile  Phe Glu Phe Pro His  Pro Asp Ala 
    1445                 1450                 1455             


Arg Leu  Gly Phe Glu Gln Ala  Phe Asp Glu Ala Lys  Arg Lys Leu 
    1460                 1465                 1470             


Ala Ser  Ser Lys Ser Cys Leu  Asp Pro Glu Phe Leu  Lys Ala Ile 
    1475                 1480                 1485             


Pro Ile  Met Lys Thr Arg Ser  Gly Met Gln Phe Ser  Cys Ala Ala 
    1490                 1495                 1500             


Pro Thr  Leu Asn Ser Cys Pro  Glu Pro Ser Pro Glu  Val Trp Val 
    1505                 1510                 1515             


Cys Asn  Ser Asp Gly Tyr Val  Gly Gln Val Cys Leu  Leu Ser Leu 
    1520                 1525                 1530             


Arg Ala  Glu Pro Asp Val Glu  Ala Cys Ile Ala Val  Cys Ser Ala 
    1535                 1540                 1545             


Arg Ile  Leu Cys Ile Gly Ala  Val Pro Gly Leu Gln  Pro Arg Cys 
    1550                 1555                 1560             


His Arg  Glu Pro Pro Pro Ser  Leu Arg Ser Pro Pro  Glu Thr Ala 
    1565                 1570                 1575             


Pro Glu  Pro Ala Gly Pro Glu  Leu Asp Val Glu Ala  Ala Ala Asp 
    1580                 1585                 1590             


Glu Glu  Ala Ala Thr Leu Ala  Glu Pro Gly Pro Gln  Pro Cys Leu 
    1595                 1600                 1605             


His Ile  Ser Ile Ala Gly Ser  Gly Leu Glu Met Thr  Pro Gly Leu 
    1610                 1615                 1620             


Gly Glu  Gly Asp Pro Arg Pro  Glu Leu Val Pro Phe  Asp Ser Asp 
    1625                 1630                 1635             


Ser Asp  Asp Glu Ser Ser Pro  Ser Pro Ser Gly Thr  Leu Gln Ser 
    1640                 1645                 1650             


Gln Ala  Ser Arg Ser Thr Ile  Ser Ser Ser Phe Gly  Asn Glu Glu 
    1655                 1660                 1665             


Thr Pro  Ser Ser Lys Glu Ala  Thr Ala Glu Thr Thr  Ser Ser Glu 
    1670                 1675                 1680             


Glu Glu  Gln Glu Pro Gly Phe  Leu Pro Leu Ser Gly  Ser Phe Gly 
    1685                 1690                 1695             


Pro Gly  Gly Pro Cys Gly Thr  Ser Pro Met Asp Gly  Arg Ala Leu 
    1700                 1705                 1710             


Arg Arg  Ser Ser His Gly Ser  Phe Thr Arg Gly Ser  Leu Glu Asp 
    1715                 1720                 1725             


Leu Leu  Ser Val Asp Pro Glu  Ala Tyr Gln Ser Ser  Val Trp Leu 
    1730                 1735                 1740             


Gly Thr  Glu Asp Gly Cys Val  His Val Tyr Gln Ser  Ser Asp Ser 
    1745                 1750                 1755             


Ile Arg  Asp Arg Arg Asn Ser  Met Lys Leu Gln His  Ala Ala Ser 
    1760                 1765                 1770             


Val Thr  Cys Ile Leu Tyr Leu  Asn Asn Gln Val Phe  Val Ser Leu 
    1775                 1780                 1785             


Ala Asn  Gly Glu Leu Val Val  Tyr Gln Arg Glu Ala  Gly His Phe 
    1790                 1795                 1800             


Trp Asp  Pro Gln Asn Phe Lys  Ser Val Thr Leu Gly  Thr Gln Gly 
    1805                 1810                 1815             


Ser Pro  Ile Thr Lys Met Val  Ser Val Gly Gly Arg  Leu Trp Cys 
    1820                 1825                 1830             


Gly Cys  Gln Asn Arg Val Leu  Val Leu Ser Pro Asp  Thr Leu Gln 
    1835                 1840                 1845             


Leu Glu  His Met Phe Tyr Val  Gly Gln Asp Ser Ser  Arg Cys Val 
    1850                 1855                 1860             


Ala Cys  Met Val Asp Ser Ser  Leu Gly Val Trp Val  Thr Leu Lys 
    1865                 1870                 1875             


Gly Ser  Ala His Val Cys Leu  Tyr His Pro Asp Thr  Phe Glu Gln 
    1880                 1885                 1890             


Leu Ala  Glu Val Asp Val Thr  Pro Pro Val His Arg  Met Leu Ala 
    1895                 1900                 1905             


Gly Ser  Asp Ala Ile Ile Arg  Gln His Lys Ala Ala  Cys Leu Arg 
    1910                 1915                 1920             


Ile Thr  Ala Leu Leu Val Cys  Glu Glu Leu Leu Trp  Val Gly Thr 
    1925                 1930                 1935             


Ser Ala  Gly Val Val Leu Thr  Met Pro Thr Ser Pro  Gly Thr Val 
    1940                 1945                 1950             


Ser Cys  Pro Arg Ala Pro Leu  Ser Pro Thr Gly Leu  Gly Gln Gly 
    1955                 1960                 1965             


His Thr  Gly His Val Arg Phe  Leu Ala Ala Val Gln  Leu Pro Asp 
    1970                 1975                 1980             


Gly Phe  Asn Leu Leu Cys Pro  Thr Pro Pro Pro Pro  Pro Asp Thr 
    1985                 1990                 1995             


Gly Pro  Glu Lys Leu Pro Ser  Leu Glu His Arg Asp  Ser Pro Trp 
    2000                 2005                 2010             


His Arg  Gly Pro Ala Pro Ala  Arg Pro Lys Met Leu  Val Ile Ser 
    2015                 2020                 2025             


Gly Gly  Asp Gly Tyr Glu Asp  Phe Arg Leu Ser Ser  Gly Gly Gly 
    2030                 2035                 2040             


Ser Ser  Ser Glu Thr Val Gly  Arg Asp Asp Ser Thr  Asn His Leu 
    2045                 2050                 2055             


Leu Leu  Trp Arg Val 
    2060             


<210>  49
<211>  3673
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (379)..(2484)

<400>  49
accactgcct gcaggttggc gccaccaccc ccactctccc cgctgctcgc gggagccaga       60

gggccctgcg gtcctcggtg gtcttgccag cccctcgtca tcccagggcc ctccgcgcct      120

gtgaggactc cctcagcgtg caaacagcag gctcagccca ggctccaggg tgtcctgggc      180

acctggtgtc ctgggagcaa agtctttgcc taacgtcgct gagaagaatg tttaaagtga      240

aagtacattg gagtctgcaa acaggacaga cccgaggcct cacgtgggac cagtcaggcc      300

tctaagcacc gcctccctaa cgccacggtg ttttccgaga tcaagggaaa ggtcggccac      360

gggacctgac gcaacagg atg gac gag tcc cct gag cct ctg cag cag ggc        411
                    Met Asp Glu Ser Pro Glu Pro Leu Gln Gln Gly           
                    1               5                   10                

aga ggg ccg gtg ccg gtc cga cgg cag cgc cca gca ccc cgg ggt ctg        459
Arg Gly Pro Val Pro Val Arg Arg Gln Arg Pro Ala Pro Arg Gly Leu           
            15                  20                  25                    

cgt gag atg ctg aag gcc agg ctg tgg tgc agc tgc tcg tgc agt gtg        507
Arg Glu Met Leu Lys Ala Arg Leu Trp Cys Ser Cys Ser Cys Ser Val           
        30                  35                  40                        

ctg tgc gtc cgg gcg ctg gtg cag gac ctg ctc ccc gcc acg cgc tgg        555
Leu Cys Val Arg Ala Leu Val Gln Asp Leu Leu Pro Ala Thr Arg Trp           
    45                  50                  55                            

ctg cgt cag tac cgc ccg cgg gag tac ctg gca ggc gac gtc atg tct        603
Leu Arg Gln Tyr Arg Pro Arg Glu Tyr Leu Ala Gly Asp Val Met Ser           
60                  65                  70                  75            

ggg ctg gtc atc ggc atc atc ctg gtg ccg cag gcc atc gcc tac tca        651
Gly Leu Val Ile Gly Ile Ile Leu Val Pro Gln Ala Ile Ala Tyr Ser           
                80                  85                  90                

ttg ctg gcc ggg ctg cag ccc atc tac agc ctc tat acg tcc ttc ttc        699
Leu Leu Ala Gly Leu Gln Pro Ile Tyr Ser Leu Tyr Thr Ser Phe Phe           
            95                  100                 105                   

gcc aac ctc atc tac ttc ctc atg ggc acc tca cgg cat gtc tcc gtg        747
Ala Asn Leu Ile Tyr Phe Leu Met Gly Thr Ser Arg His Val Ser Val           
        110                 115                 120                       

ggc atc ttc agc ctg ctt tgc ctc atg gtg ggg cag gtg gtg gac cgg        795
Gly Ile Phe Ser Leu Leu Cys Leu Met Val Gly Gln Val Val Asp Arg           
    125                 130                 135                           

gag ctc cag ctg gcc ggc ttt gac ccc tcc cag gac ggc ctg cag ccc        843
Glu Leu Gln Leu Ala Gly Phe Asp Pro Ser Gln Asp Gly Leu Gln Pro           
140                 145                 150                 155           

gga gcc aac agc agc acc ctc aac ggc tcg gct gcc atg ctg gac tgc        891
Gly Ala Asn Ser Ser Thr Leu Asn Gly Ser Ala Ala Met Leu Asp Cys           
                160                 165                 170               

ggg cgt gac tgc tac gcc atc cgt gtc gcc acc gcc ctc acg ctg atg        939
Gly Arg Asp Cys Tyr Ala Ile Arg Val Ala Thr Ala Leu Thr Leu Met           
            175                 180                 185                   

acc ggg ctt tac cag gtc ctc atg ggc gtc ctc cgg ctg ggc ttc gtg        987
Thr Gly Leu Tyr Gln Val Leu Met Gly Val Leu Arg Leu Gly Phe Val           
        190                 195                 200                       

tcc gcc tac ctc tca cag cca ctg ctc gat ggc ttt gcc atg ggg gcc       1035
Ser Ala Tyr Leu Ser Gln Pro Leu Leu Asp Gly Phe Ala Met Gly Ala           
    205                 210                 215                           

tcc gtg acc atc ctg acc tcg cag ctc aaa cac ctg ctg ggc gtg cgg       1083
Ser Val Thr Ile Leu Thr Ser Gln Leu Lys His Leu Leu Gly Val Arg           
220                 225                 230                 235           

atc ccg cgg cac cag ggg ccc ggc atg gtg gtc ctc aca tgg ctg agc       1131
Ile Pro Arg His Gln Gly Pro Gly Met Val Val Leu Thr Trp Leu Ser           
                240                 245                 250               

ctg ctg cgc ggc gcc ggg cag gcc aac gtg tgc gac gtg gtc acc agc       1179
Leu Leu Arg Gly Ala Gly Gln Ala Asn Val Cys Asp Val Val Thr Ser           
            255                 260                 265                   

acg gtg tgc ctg gcg gtg ctg cta gcc gcg aag gag ctc tca gac cgc       1227
Thr Val Cys Leu Ala Val Leu Leu Ala Ala Lys Glu Leu Ser Asp Arg           
        270                 275                 280                       

tac cga cac cgc ctg agg gtg ccg ctg ccc acg gag ctg ctg gtc atc       1275
Tyr Arg His Arg Leu Arg Val Pro Leu Pro Thr Glu Leu Leu Val Ile           
    285                 290                 295                           

gtg gtg gcc aca ctc gtg tcg cac ttc ggg cag ctc cac aag cgc ttt       1323
Val Val Ala Thr Leu Val Ser His Phe Gly Gln Leu His Lys Arg Phe           
300                 305                 310                 315           

ggc tcg agc gtg gct ggc gac atc ccc acg ggt ttc atg ccc cct cag       1371
Gly Ser Ser Val Ala Gly Asp Ile Pro Thr Gly Phe Met Pro Pro Gln           
                320                 325                 330               

gtc cca gag ccc agg ctg atg cag cgt gtg gct ttg gat gcc gtg gcc       1419
Val Pro Glu Pro Arg Leu Met Gln Arg Val Ala Leu Asp Ala Val Ala           
            335                 340                 345                   

ctg gcc ctc gtg gct gcc gcc ttc tcc atc tcg ctg gcg gag atg ttc       1467
Leu Ala Leu Val Ala Ala Ala Phe Ser Ile Ser Leu Ala Glu Met Phe           
        350                 355                 360                       

gcc cgc agt cac ggc tac tct gtg cgt gcc aac cag gag ctg ctg gct       1515
Ala Arg Ser His Gly Tyr Ser Val Arg Ala Asn Gln Glu Leu Leu Ala           
    365                 370                 375                           

gtg ggc tgc tgc aac gtg cta ccc gcc ttc ctc cac tgc ttc gcc acc       1563
Val Gly Cys Cys Asn Val Leu Pro Ala Phe Leu His Cys Phe Ala Thr           
380                 385                 390                 395           

agc gcc gcc ctg gcc aag agc ctg gtg aag aca gcc act ggc tgc cgg       1611
Ser Ala Ala Leu Ala Lys Ser Leu Val Lys Thr Ala Thr Gly Cys Arg           
                400                 405                 410               

aca cag ctg tcc agc gtg gtc agc gcc acc gtg gtg ctg ctg gtg ctg       1659
Thr Gln Leu Ser Ser Val Val Ser Ala Thr Val Val Leu Leu Val Leu           
            415                 420                 425                   

ctg gcg ctg gca ccg ctg ttc cac gac cta cag cga agc gtg ctg gcc       1707
Leu Ala Leu Ala Pro Leu Phe His Asp Leu Gln Arg Ser Val Leu Ala           
        430                 435                 440                       

tgc gtc atc gtg gtc agc ctg cgg ggg gcc ctg cgc aag gtg tgg gac       1755
Cys Val Ile Val Val Ser Leu Arg Gly Ala Leu Arg Lys Val Trp Asp           
    445                 450                 455                           

ctc ccg cgg ctg tgg cgg atg agc ccg gct gac gcg ctg gtc tgg gca       1803
Leu Pro Arg Leu Trp Arg Met Ser Pro Ala Asp Ala Leu Val Trp Ala           
460                 465                 470                 475           

ggc acc gcg gcc acc tgt atg ctg gtc agc aca gag gcc ggg ctg ctg       1851
Gly Thr Ala Ala Thr Cys Met Leu Val Ser Thr Glu Ala Gly Leu Leu           
                480                 485                 490               

gct ggc gtc atc ctc tcg ctg ctc agc ctg gcc ggc cgc acc caa cgc       1899
Ala Gly Val Ile Leu Ser Leu Leu Ser Leu Ala Gly Arg Thr Gln Arg           
            495                 500                 505                   

cca cgc acc gcc ctg ctg gcc cgc atc ggg gac acg gcc ttc tac gag       1947
Pro Arg Thr Ala Leu Leu Ala Arg Ile Gly Asp Thr Ala Phe Tyr Glu           
        510                 515                 520                       

gat gcc aca gag ttc gag ggc ctc gtc cct gag ccc ggc gtg cgg gtg       1995
Asp Ala Thr Glu Phe Glu Gly Leu Val Pro Glu Pro Gly Val Arg Val           
    525                 530                 535                           

ttc cgc ttt ggg ggg ccg ctg tac tat gcc aac aag gac ttc ttc ctg       2043
Phe Arg Phe Gly Gly Pro Leu Tyr Tyr Ala Asn Lys Asp Phe Phe Leu           
540                 545                 550                 555           

cag tca ctc tac agc ctc acg ggg ctg gac gca ggg tgc atg gct gcc       2091
Gln Ser Leu Tyr Ser Leu Thr Gly Leu Asp Ala Gly Cys Met Ala Ala           
                560                 565                 570               

agg agg aag gag ggg ggc tca gag acg ggg gtc ggt gag gga ggc cct       2139
Arg Arg Lys Glu Gly Gly Ser Glu Thr Gly Val Gly Glu Gly Gly Pro           
            575                 580                 585                   

gcc cag ggc gag gac ctg ggc ccg gtt agc acc agg gct gcg ctg gtg       2187
Ala Gln Gly Glu Asp Leu Gly Pro Val Ser Thr Arg Ala Ala Leu Val           
        590                 595                 600                       

ccc gca gcg gcc ggc ttc cac aca gtg gtc atc gac tgc gcc ccg ctg       2235
Pro Ala Ala Ala Gly Phe His Thr Val Val Ile Asp Cys Ala Pro Leu           
    605                 610                 615                           

ctg ttc cta gac gca gcc ggt gtg agc acg ctg cag gac ctg cgc cga       2283
Leu Phe Leu Asp Ala Ala Gly Val Ser Thr Leu Gln Asp Leu Arg Arg           
620                 625                 630                 635           

gac tac ggg gcc ctg ggc atc agc ctg ctg cta gcc tgc tgc agc ccg       2331
Asp Tyr Gly Ala Leu Gly Ile Ser Leu Leu Leu Ala Cys Cys Ser Pro           
                640                 645                 650               

cct gtg aga gac att ctg agc aga gga ggc ttc ctc ggg gag ggc ccc       2379
Pro Val Arg Asp Ile Leu Ser Arg Gly Gly Phe Leu Gly Glu Gly Pro           
            655                 660                 665                   

ggg gac acg gct gag gag gag cag ctg ttc ctc agt gtg cac gat gcc       2427
Gly Asp Thr Ala Glu Glu Glu Gln Leu Phe Leu Ser Val His Asp Ala           
        670                 675                 680                       

gtg cag aca gca cga gcc cgc cac agg gag ctg gag gcc acc gat gcc       2475
Val Gln Thr Ala Arg Ala Arg His Arg Glu Leu Glu Ala Thr Asp Ala           
    685                 690                 695                           

cat ctg tag cagggccagg cctgcccagc agcctctgct ccctcctggg               2524
His Leu                                                                   
700                                                                       

gacccacagc agacgtctgc aagccactgc tgagaccctt cccagggagg agccacccaa     2584

gagctgcact cttgtgccac agctgccctg gggaaaccgg ggaaccccaa ctgggaaagg     2644

aggccctctg atcacacgca ggacccaaac actcagaaat caagaacctc tgcctccgag     2704

acaggctggc ccacagtgct ggctgggccc caatgcaccg tccctcagct caggagggat     2764

gggcctgacc tgacgctcag ggttgacatc ttatttgaac aagggtcccc cgccatcatg     2824

cagcctccaa ggtgccaaga ggactcccta tgcccaggcc tgcccggtgc ccaccctgct     2884

ggtaggagcc agcggctctg gccaagtgca cgagggtctc tgtgtttcca gaaggcccca     2944

cacacccaag tgcccctcac acctcgtgcc tccccctcac agggtggcca cctgcaccag     3004

cgtcagggcc cagggtgctg tgaccgatga gacctcagct cagccctcag gtgcagtggc     3064

cctacccagc ctggccagca gacacacaca gggatgctca cgggtgcacc aggagccagg     3124

tgcggcgcag ccaaccctga gcctgcaggg agacctgcag gaagcccacc gtgccccatg     3184

caggggctcc ctccagcaca cagccctcac cccagcacag ccagcaagga cacgctctcc     3244

ccaacagggt gcttcggcgg gaggtggggg aacaaggggt cttccgagca gcccccagcc     3304

ctcccctccc atctgtgcct ctgtaagggg ctctgggacg cccagaccct gcccgccgcc     3364

cacctggtgg tgacaagctc cagcagccag tgggtccgga cctgcttgat gccgcggtga     3424

gggacggcgc ccacataggc gaggttgagc tgctggtccc agctgaggac gtactggtca     3484

gcctggctgt gtggcagcgg ggggctgggg acaacaaagg ggcggctcag tcccgagcct     3544

cagcatggct ggcagcgcgg ctgacacaca cgttcaagcc caggactgcc cgggcgcagg     3604

atccaggcgc tgcccgtgcg ttcagtgact aataaaatga cccttagggc caggaaaaaa     3664

aaaaaaaaa                                                             3673


<210>  50
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Asp Glu Ser Pro Glu Pro Leu Gln Gln Gly Arg Gly Pro Val Pro 
1               5                   10                  15      


Val Arg Arg Gln Arg Pro Ala Pro Arg Gly Leu Arg Glu Met Leu Lys 
            20                  25                  30          


Ala Arg Leu Trp Cys Ser Cys Ser Cys Ser Val Leu Cys Val Arg Ala 
        35                  40                  45              


Leu Val Gln Asp Leu Leu Pro Ala Thr Arg Trp Leu Arg Gln Tyr Arg 
    50                  55                  60                  


Pro Arg Glu Tyr Leu Ala Gly Asp Val Met Ser Gly Leu Val Ile Gly 
65                  70                  75                  80  


Ile Ile Leu Val Pro Gln Ala Ile Ala Tyr Ser Leu Leu Ala Gly Leu 
                85                  90                  95      


Gln Pro Ile Tyr Ser Leu Tyr Thr Ser Phe Phe Ala Asn Leu Ile Tyr 
            100                 105                 110         


Phe Leu Met Gly Thr Ser Arg His Val Ser Val Gly Ile Phe Ser Leu 
        115                 120                 125             


Leu Cys Leu Met Val Gly Gln Val Val Asp Arg Glu Leu Gln Leu Ala 
    130                 135                 140                 


Gly Phe Asp Pro Ser Gln Asp Gly Leu Gln Pro Gly Ala Asn Ser Ser 
145                 150                 155                 160 


Thr Leu Asn Gly Ser Ala Ala Met Leu Asp Cys Gly Arg Asp Cys Tyr 
                165                 170                 175     


Ala Ile Arg Val Ala Thr Ala Leu Thr Leu Met Thr Gly Leu Tyr Gln 
            180                 185                 190         


Val Leu Met Gly Val Leu Arg Leu Gly Phe Val Ser Ala Tyr Leu Ser 
        195                 200                 205             


Gln Pro Leu Leu Asp Gly Phe Ala Met Gly Ala Ser Val Thr Ile Leu 
    210                 215                 220                 


Thr Ser Gln Leu Lys His Leu Leu Gly Val Arg Ile Pro Arg His Gln 
225                 230                 235                 240 


Gly Pro Gly Met Val Val Leu Thr Trp Leu Ser Leu Leu Arg Gly Ala 
                245                 250                 255     


Gly Gln Ala Asn Val Cys Asp Val Val Thr Ser Thr Val Cys Leu Ala 
            260                 265                 270         


Val Leu Leu Ala Ala Lys Glu Leu Ser Asp Arg Tyr Arg His Arg Leu 
        275                 280                 285             


Arg Val Pro Leu Pro Thr Glu Leu Leu Val Ile Val Val Ala Thr Leu 
    290                 295                 300                 


Val Ser His Phe Gly Gln Leu His Lys Arg Phe Gly Ser Ser Val Ala 
305                 310                 315                 320 


Gly Asp Ile Pro Thr Gly Phe Met Pro Pro Gln Val Pro Glu Pro Arg 
                325                 330                 335     


Leu Met Gln Arg Val Ala Leu Asp Ala Val Ala Leu Ala Leu Val Ala 
            340                 345                 350         


Ala Ala Phe Ser Ile Ser Leu Ala Glu Met Phe Ala Arg Ser His Gly 
        355                 360                 365             


Tyr Ser Val Arg Ala Asn Gln Glu Leu Leu Ala Val Gly Cys Cys Asn 
    370                 375                 380                 


Val Leu Pro Ala Phe Leu His Cys Phe Ala Thr Ser Ala Ala Leu Ala 
385                 390                 395                 400 


Lys Ser Leu Val Lys Thr Ala Thr Gly Cys Arg Thr Gln Leu Ser Ser 
                405                 410                 415     


Val Val Ser Ala Thr Val Val Leu Leu Val Leu Leu Ala Leu Ala Pro 
            420                 425                 430         


Leu Phe His Asp Leu Gln Arg Ser Val Leu Ala Cys Val Ile Val Val 
        435                 440                 445             


Ser Leu Arg Gly Ala Leu Arg Lys Val Trp Asp Leu Pro Arg Leu Trp 
    450                 455                 460                 


Arg Met Ser Pro Ala Asp Ala Leu Val Trp Ala Gly Thr Ala Ala Thr 
465                 470                 475                 480 


Cys Met Leu Val Ser Thr Glu Ala Gly Leu Leu Ala Gly Val Ile Leu 
                485                 490                 495     


Ser Leu Leu Ser Leu Ala Gly Arg Thr Gln Arg Pro Arg Thr Ala Leu 
            500                 505                 510         


Leu Ala Arg Ile Gly Asp Thr Ala Phe Tyr Glu Asp Ala Thr Glu Phe 
        515                 520                 525             


Glu Gly Leu Val Pro Glu Pro Gly Val Arg Val Phe Arg Phe Gly Gly 
    530                 535                 540                 


Pro Leu Tyr Tyr Ala Asn Lys Asp Phe Phe Leu Gln Ser Leu Tyr Ser 
545                 550                 555                 560 


Leu Thr Gly Leu Asp Ala Gly Cys Met Ala Ala Arg Arg Lys Glu Gly 
                565                 570                 575     


Gly Ser Glu Thr Gly Val Gly Glu Gly Gly Pro Ala Gln Gly Glu Asp 
            580                 585                 590         


Leu Gly Pro Val Ser Thr Arg Ala Ala Leu Val Pro Ala Ala Ala Gly 
        595                 600                 605             


Phe His Thr Val Val Ile Asp Cys Ala Pro Leu Leu Phe Leu Asp Ala 
    610                 615                 620                 


Ala Gly Val Ser Thr Leu Gln Asp Leu Arg Arg Asp Tyr Gly Ala Leu 
625                 630                 635                 640 


Gly Ile Ser Leu Leu Leu Ala Cys Cys Ser Pro Pro Val Arg Asp Ile 
                645                 650                 655     


Leu Ser Arg Gly Gly Phe Leu Gly Glu Gly Pro Gly Asp Thr Ala Glu 
            660                 665                 670         


Glu Glu Gln Leu Phe Leu Ser Val His Asp Ala Val Gln Thr Ala Arg 
        675                 680                 685             


Ala Arg His Arg Glu Leu Glu Ala Thr Asp Ala His Leu 
    690                 695                 700     


<210>  51
<211>  1956
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (14)..(1465)

<400>  51
ctactgtgag ggg atg aag gtg ctc cct gca tct ggc ctt gct gtc ttc          49
               Met Lys Val Leu Pro Ala Ser Gly Leu Ala Val Phe            
               1               5                   10                     

ctc atc atg gct ttg aag ttt tcc act gca gcc ccc tcc cta gtt gca         97
Leu Ile Met Ala Leu Lys Phe Ser Thr Ala Ala Pro Ser Leu Val Ala           
        15                  20                  25                        

gcc tcc ccc agg acc tgg agg aac aac tac cgc ctc gca cag gcg tat        145
Ala Ser Pro Arg Thr Trp Arg Asn Asn Tyr Arg Leu Ala Gln Ala Tyr           
    30                  35                  40                            

ctt gac aaa tat tac aca aat aaa gaa gga cac cag att ggt gag atg        193
Leu Asp Lys Tyr Tyr Thr Asn Lys Glu Gly His Gln Ile Gly Glu Met           
45                  50                  55                  60            

gtt gca aga gga agc aat tcc atg ata agg aag att aag gag cta caa        241
Val Ala Arg Gly Ser Asn Ser Met Ile Arg Lys Ile Lys Glu Leu Gln           
                65                  70                  75                

gcg ttc ttt ggc ctc caa gtc acc ggg aag tta gac cag acc aca atg        289
Ala Phe Phe Gly Leu Gln Val Thr Gly Lys Leu Asp Gln Thr Thr Met           
            80                  85                  90                    

aac gtg atc aag aag cct cgc tgt gga gtt cct gat gtg gcc aat tat        337
Asn Val Ile Lys Lys Pro Arg Cys Gly Val Pro Asp Val Ala Asn Tyr           
        95                  100                 105                       

cgc ctc ttc cct ggt gaa ccc aaa tgg aaa aaa aat act ttg aca tac        385
Arg Leu Phe Pro Gly Glu Pro Lys Trp Lys Lys Asn Thr Leu Thr Tyr           
    110                 115                 120                           

aga ata tct aaa tac aca cct tcc atg agt tct gtc gag gtg gac aaa        433
Arg Ile Ser Lys Tyr Thr Pro Ser Met Ser Ser Val Glu Val Asp Lys           
125                 130                 135                 140           

gca gtg gag atg gcc ttg cag gcc tgg agt agc gcc gtc cct ctg agc        481
Ala Val Glu Met Ala Leu Gln Ala Trp Ser Ser Ala Val Pro Leu Ser           
                145                 150                 155               

ttt gtc aga ata aac tca gga gaa gcg gat att atg ata tct ttt gaa        529
Phe Val Arg Ile Asn Ser Gly Glu Ala Asp Ile Met Ile Ser Phe Glu           
            160                 165                 170                   

aat gga gat cac ggg gat tcc tat cca ttc gat ggg cct cgg ggg act        577
Asn Gly Asp His Gly Asp Ser Tyr Pro Phe Asp Gly Pro Arg Gly Thr           
        175                 180                 185                       

cta gcc cat gca ttt gct cct gga gaa ggc ctg gga gga gat aca cat        625
Leu Ala His Ala Phe Ala Pro Gly Glu Gly Leu Gly Gly Asp Thr His           
    190                 195                 200                           

ttc gac aat gct gag aag tgg act atg gga acg aat ggt ttt aat ttg        673
Phe Asp Asn Ala Glu Lys Trp Thr Met Gly Thr Asn Gly Phe Asn Leu           
205                 210                 215                 220           

ttt acc gtt gct gct cat gaa ttt ggc cat gcc ctg ggc ctg gcc cat        721
Phe Thr Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu Ala His           
                225                 230                 235               

tcc aca gac cca tca gca ctg atg tac cca act tat aag tac aag aat        769
Ser Thr Asp Pro Ser Ala Leu Met Tyr Pro Thr Tyr Lys Tyr Lys Asn           
            240                 245                 250                   

ccc tat gga ttc cac ctc ccc aaa gat gat gtg aaa ggg atc cag gca        817
Pro Tyr Gly Phe His Leu Pro Lys Asp Asp Val Lys Gly Ile Gln Ala           
        255                 260                 265                       

tta tac gga cct cgg aaa gta ttc ctg ggg aag ccc act ctg ccc cat        865
Leu Tyr Gly Pro Arg Lys Val Phe Leu Gly Lys Pro Thr Leu Pro His           
    270                 275                 280                           

gcc ccc cat cac aag cca tcc atc cct gac ctc tgt gac tcc agc tca        913
Ala Pro His His Lys Pro Ser Ile Pro Asp Leu Cys Asp Ser Ser Ser           
285                 290                 295                 300           

tcc ttt gac gct gtg aca atg ctg ggg aag gag ctc ctg ctc ttc aag        961
Ser Phe Asp Ala Val Thr Met Leu Gly Lys Glu Leu Leu Leu Phe Lys           
                305                 310                 315               

gac cgg att ttc tgg aga cgg cag gtt cac ttg cgg aca gga att cgg       1009
Asp Arg Ile Phe Trp Arg Arg Gln Val His Leu Arg Thr Gly Ile Arg           
            320                 325                 330                   

ccc agc act att acc agc tcc ttc ccc cag ctc atg tcc aat gtg gat       1057
Pro Ser Thr Ile Thr Ser Ser Phe Pro Gln Leu Met Ser Asn Val Asp           
        335                 340                 345                       

gca gct tac gaa gtg gct gag agg ggc act gct tac ttc ttc aaa ggt       1105
Ala Ala Tyr Glu Val Ala Glu Arg Gly Thr Ala Tyr Phe Phe Lys Gly           
    350                 355                 360                           

ccc cac tac tgg ata aca aga gga ttc caa atg caa ggt cct cct cgg       1153
Pro His Tyr Trp Ile Thr Arg Gly Phe Gln Met Gln Gly Pro Pro Arg           
365                 370                 375                 380           

act att tat gac ttt gga ttt cca agg cac gtg cag caa ata gat gct       1201
Thr Ile Tyr Asp Phe Gly Phe Pro Arg His Val Gln Gln Ile Asp Ala           
                385                 390                 395               

gct gtc tac ctc agg gag cca cag aag acc ctt ttc ttt gtg gga gat       1249
Ala Val Tyr Leu Arg Glu Pro Gln Lys Thr Leu Phe Phe Val Gly Asp           
            400                 405                 410                   

gaa tac tac agc tac gac gaa agg aaa agg aaa atg gaa aaa gac tat       1297
Glu Tyr Tyr Ser Tyr Asp Glu Arg Lys Arg Lys Met Glu Lys Asp Tyr           
        415                 420                 425                       

cca aag aat act gaa gaa gaa ttt tca gga gta aat ggc caa atc gat       1345
Pro Lys Asn Thr Glu Glu Glu Phe Ser Gly Val Asn Gly Gln Ile Asp           
    430                 435                 440                           

gct gct gta gaa tta aat ggc tac att tac ttc ttt tca gga cca aaa       1393
Ala Ala Val Glu Leu Asn Gly Tyr Ile Tyr Phe Phe Ser Gly Pro Lys           
445                 450                 455                 460           

aca tac aag tat gac aca gag aag gaa gat gtg gtt agt gtg gtg aaa       1441
Thr Tyr Lys Tyr Asp Thr Glu Lys Glu Asp Val Val Ser Val Val Lys           
                465                 470                 475               

tct agt tcc tgg att ggt tgc taa atagaaaagc ctagtcttct caagcaatga      1495
Ser Ser Ser Trp Ile Gly Cys                                               
            480                                                           

ggatgactac aagcagcctc taactggatc ttaaggacta aagcagaatg taggagaggg     1555

attcttccaa aggccttcaa atcaaattag aattcactga gaataataat acttccaatt     1615

tttttcatag ttgtataatc agaatttcaa tccacattag aaaagttttt atatgggcaa     1675

ctttatgcga aatccaaatc aacacaatgc actctgcagt tagacaccat tattttttct     1735

tacctaatat actgaagcag attgatccgt ttgattttta tttccaggag gaagactagt     1795

ggtggattcc atgacatata ttgtaattct tttcatagga aatgtcatta cagtatgaat     1855

tataattatt tacaagcaat ggcttttgtg gccatcattt ggccatcatt tgttataata     1915

aatataaatt tcccaatttt tacttaaaag acatcacaac a                         1956


<210>  52
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Lys Val Leu Pro Ala Ser Gly Leu Ala Val Phe Leu Ile Met Ala 
1               5                   10                  15      


Leu Lys Phe Ser Thr Ala Ala Pro Ser Leu Val Ala Ala Ser Pro Arg 
            20                  25                  30          


Thr Trp Arg Asn Asn Tyr Arg Leu Ala Gln Ala Tyr Leu Asp Lys Tyr 
        35                  40                  45              


Tyr Thr Asn Lys Glu Gly His Gln Ile Gly Glu Met Val Ala Arg Gly 
    50                  55                  60                  


Ser Asn Ser Met Ile Arg Lys Ile Lys Glu Leu Gln Ala Phe Phe Gly 
65                  70                  75                  80  


Leu Gln Val Thr Gly Lys Leu Asp Gln Thr Thr Met Asn Val Ile Lys 
                85                  90                  95      


Lys Pro Arg Cys Gly Val Pro Asp Val Ala Asn Tyr Arg Leu Phe Pro 
            100                 105                 110         


Gly Glu Pro Lys Trp Lys Lys Asn Thr Leu Thr Tyr Arg Ile Ser Lys 
        115                 120                 125             


Tyr Thr Pro Ser Met Ser Ser Val Glu Val Asp Lys Ala Val Glu Met 
    130                 135                 140                 


Ala Leu Gln Ala Trp Ser Ser Ala Val Pro Leu Ser Phe Val Arg Ile 
145                 150                 155                 160 


Asn Ser Gly Glu Ala Asp Ile Met Ile Ser Phe Glu Asn Gly Asp His 
                165                 170                 175     


Gly Asp Ser Tyr Pro Phe Asp Gly Pro Arg Gly Thr Leu Ala His Ala 
            180                 185                 190         


Phe Ala Pro Gly Glu Gly Leu Gly Gly Asp Thr His Phe Asp Asn Ala 
        195                 200                 205             


Glu Lys Trp Thr Met Gly Thr Asn Gly Phe Asn Leu Phe Thr Val Ala 
    210                 215                 220                 


Ala His Glu Phe Gly His Ala Leu Gly Leu Ala His Ser Thr Asp Pro 
225                 230                 235                 240 


Ser Ala Leu Met Tyr Pro Thr Tyr Lys Tyr Lys Asn Pro Tyr Gly Phe 
                245                 250                 255     


His Leu Pro Lys Asp Asp Val Lys Gly Ile Gln Ala Leu Tyr Gly Pro 
            260                 265                 270         


Arg Lys Val Phe Leu Gly Lys Pro Thr Leu Pro His Ala Pro His His 
        275                 280                 285             


Lys Pro Ser Ile Pro Asp Leu Cys Asp Ser Ser Ser Ser Phe Asp Ala 
    290                 295                 300                 


Val Thr Met Leu Gly Lys Glu Leu Leu Leu Phe Lys Asp Arg Ile Phe 
305                 310                 315                 320 


Trp Arg Arg Gln Val His Leu Arg Thr Gly Ile Arg Pro Ser Thr Ile 
                325                 330                 335     


Thr Ser Ser Phe Pro Gln Leu Met Ser Asn Val Asp Ala Ala Tyr Glu 
            340                 345                 350         


Val Ala Glu Arg Gly Thr Ala Tyr Phe Phe Lys Gly Pro His Tyr Trp 
        355                 360                 365             


Ile Thr Arg Gly Phe Gln Met Gln Gly Pro Pro Arg Thr Ile Tyr Asp 
    370                 375                 380                 


Phe Gly Phe Pro Arg His Val Gln Gln Ile Asp Ala Ala Val Tyr Leu 
385                 390                 395                 400 


Arg Glu Pro Gln Lys Thr Leu Phe Phe Val Gly Asp Glu Tyr Tyr Ser 
                405                 410                 415     


Tyr Asp Glu Arg Lys Arg Lys Met Glu Lys Asp Tyr Pro Lys Asn Thr 
            420                 425                 430         


Glu Glu Glu Phe Ser Gly Val Asn Gly Gln Ile Asp Ala Ala Val Glu 
        435                 440                 445             


Leu Asn Gly Tyr Ile Tyr Phe Phe Ser Gly Pro Lys Thr Tyr Lys Tyr 
    450                 455                 460                 


Asp Thr Glu Lys Glu Asp Val Val Ser Val Val Lys Ser Ser Ser Trp 
465                 470                 475                 480 


Ile Gly Cys 
            


<210>  53
<211>  1318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (222)..(884)

<400>  53
agcccagtcg ccgccgcccg cccacaaagc cacaggcagg tgcaggcgca gccgcggcga       60

gagcgtatgg agccgagccg ttagcgcgcg ccgtcggtga gtcagtccgt ccgtccgtcc      120

gtccgtcggg gcgccgcagc tcccgccagg cccagcggcc ccggcccctc gtctccccgc      180

acccggagcc acccggtgga gcgggccttg ccgcggcagc c atg tcc atg ggc ctg      236
                                              Met Ser Met Gly Leu         
                                              1               5           

gag atc acg ggc acc gcg ctg gcc gtg ctg ggc tgg ctg ggc acc atc        284
Glu Ile Thr Gly Thr Ala Leu Ala Val Leu Gly Trp Leu Gly Thr Ile           
                10                  15                  20                

gtg tgc tgc gcg ttg ccc atg tgg cgc gtg tcg gcc ttc atc ggc agc        332
Val Cys Cys Ala Leu Pro Met Trp Arg Val Ser Ala Phe Ile Gly Ser           
            25                  30                  35                    

aac atc atc acg tcg cag aac atc tgg gag ggc ctg tgg atg aac tgc        380
Asn Ile Ile Thr Ser Gln Asn Ile Trp Glu Gly Leu Trp Met Asn Cys           
        40                  45                  50                        

gtg gtg cag agc acc ggc cag atg cag tgc aag gtg tac gac tcg ctg        428
Val Val Gln Ser Thr Gly Gln Met Gln Cys Lys Val Tyr Asp Ser Leu           
    55                  60                  65                            

ctg gca ctg cca cag gac ctt cag gcg gcc cgc gcc ctc atc gtg gtg        476
Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala Arg Ala Leu Ile Val Val           
70                  75                  80                  85            

gcc atc ctg ctg gcc gcc ttc ggg ctg cta gtg gcg ctg gtg ggc gcc        524
Ala Ile Leu Leu Ala Ala Phe Gly Leu Leu Val Ala Leu Val Gly Ala           
                90                  95                  100               

cag tgc acc aac tgc gtg cag gac gac acg gcc aag gcc aag atc acc        572
Gln Cys Thr Asn Cys Val Gln Asp Asp Thr Ala Lys Ala Lys Ile Thr           
            105                 110                 115                   

atc gtg gca ggc gtg ctg ttc ctt ctc gcc gcc ctg ctc acc ctc gtg        620
Ile Val Ala Gly Val Leu Phe Leu Leu Ala Ala Leu Leu Thr Leu Val           
        120                 125                 130                       

ccg gtg tcc tgg tcg gcc aac acc att atc cgg gac ttc tac aac ccc        668
Pro Val Ser Trp Ser Ala Asn Thr Ile Ile Arg Asp Phe Tyr Asn Pro           
    135                 140                 145                           

gtg gtg ccc gag gcg cag aag cgc gag atg ggc gcg ggc ctg tac gtg        716
Val Val Pro Glu Ala Gln Lys Arg Glu Met Gly Ala Gly Leu Tyr Val           
150                 155                 160                 165           

ggc tgg gcg gcc gcg gcg ctg cag ctg ctg ggg ggc gcg ctg ctc tgc        764
Gly Trp Ala Ala Ala Ala Leu Gln Leu Leu Gly Gly Ala Leu Leu Cys           
                170                 175                 180               

tgc tcg tgt ccc cca cgc gag aag aag tac acg gcc acc aag gtc gtc        812
Cys Ser Cys Pro Pro Arg Glu Lys Lys Tyr Thr Ala Thr Lys Val Val           
            185                 190                 195                   

tac tcc gcg ccg cgc tcc acc ggc ccg gga gcc agc ctg ggc aca ggc        860
Tyr Ser Ala Pro Arg Ser Thr Gly Pro Gly Ala Ser Leu Gly Thr Gly           
        200                 205                 210                       

tac gac cgc aag gac tac gtc taa gggacagacg cagggagacc ccaccaccac       914
Tyr Asp Arg Lys Asp Tyr Val                                               
    215                 220                                               

caccaccacc aacaccacca ccaccaccgc gagctggagc gcgcaccagg ccatccagcg      974

tgcagccttg cctcggaggc cagcccaccc ccagaagcca ggaagccccc gcgctggact     1034

ggggcagctt ccccagcagc cacggctttg cgggccgggc agtcgacttc ggggcccagg     1094

gaccaacctg catggactgt gaaacctcac ccttctggag cacggggcct gggtgaccgc     1154

caatacttga ccaccccgtc gagccccatc gggccgctgc ccccatgctc gcgctgggca     1214

gggaccggca gccctggaag gggcacttga tatttttcaa taaaagcctt tcgttttgca     1274

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      1318


<210>  54
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ser Met Gly Leu Glu Ile Thr Gly Thr Ala Leu Ala Val Leu Gly 
1               5                   10                  15      


Trp Leu Gly Thr Ile Val Cys Cys Ala Leu Pro Met Trp Arg Val Ser 
            20                  25                  30          


Ala Phe Ile Gly Ser Asn Ile Ile Thr Ser Gln Asn Ile Trp Glu Gly 
        35                  40                  45              


Leu Trp Met Asn Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys Lys 
    50                  55                  60                  


Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala Arg 
65                  70                  75                  80  


Ala Leu Ile Val Val Ala Ile Leu Leu Ala Ala Phe Gly Leu Leu Val 
                85                  90                  95      


Ala Leu Val Gly Ala Gln Cys Thr Asn Cys Val Gln Asp Asp Thr Ala 
            100                 105                 110         


Lys Ala Lys Ile Thr Ile Val Ala Gly Val Leu Phe Leu Leu Ala Ala 
        115                 120                 125             


Leu Leu Thr Leu Val Pro Val Ser Trp Ser Ala Asn Thr Ile Ile Arg 
    130                 135                 140                 


Asp Phe Tyr Asn Pro Val Val Pro Glu Ala Gln Lys Arg Glu Met Gly 
145                 150                 155                 160 


Ala Gly Leu Tyr Val Gly Trp Ala Ala Ala Ala Leu Gln Leu Leu Gly 
                165                 170                 175     


Gly Ala Leu Leu Cys Cys Ser Cys Pro Pro Arg Glu Lys Lys Tyr Thr 
            180                 185                 190         


Ala Thr Lys Val Val Tyr Ser Ala Pro Arg Ser Thr Gly Pro Gly Ala 
        195                 200                 205             


Ser Leu Gly Thr Gly Tyr Asp Arg Lys Asp Tyr Val 
    210                 215                 220 


<210>  55
<211>  1297
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (128)..(853)

<400>  55
gtgagagcca ggcgtccctc tgcctgccca ctcagtggca acacccggga gctgttttgt       60

cctttgtgga gcctcagcag ttccctcttt cagaactcac tgccaagagc cctgaacagg      120

agccacc atg cag tgc ttc agc ttc att aag acc atg atg atc ctc ttc        169
        Met Gln Cys Phe Ser Phe Ile Lys Thr Met Met Ile Leu Phe           
        1               5                   10                            

aat ttg ctc atc ttt ctg tgt ggt gca gcc ctg ttg gca gtg ggc atc        217
Asn Leu Leu Ile Phe Leu Cys Gly Ala Ala Leu Leu Ala Val Gly Ile           
15                  20                  25                  30            

tgg gtg tca atc gat ggg gca tcc ttt ctg aag atc ttc ggg cca ctg        265
Trp Val Ser Ile Asp Gly Ala Ser Phe Leu Lys Ile Phe Gly Pro Leu           
                35                  40                  45                

tcg tcc agt gcc atg cag ttt gtc aac gtg ggc tac ttc ctc atc gca        313
Ser Ser Ser Ala Met Gln Phe Val Asn Val Gly Tyr Phe Leu Ile Ala           
            50                  55                  60                    

gcc ggc gtt gtg gtc ttt gct ctt ggt ttc ctg ggc tgc tat ggt gct        361
Ala Gly Val Val Val Phe Ala Leu Gly Phe Leu Gly Cys Tyr Gly Ala           
        65                  70                  75                        

aag act gag agc aag tgt gcc ctc gtg acg ttc ttc ttc atc ctc ctc        409
Lys Thr Glu Ser Lys Cys Ala Leu Val Thr Phe Phe Phe Ile Leu Leu           
    80                  85                  90                            

ctc atc ttc att gct gag gtt gca gct gct gtg gtc gcc ttg gtg tac        457
Leu Ile Phe Ile Ala Glu Val Ala Ala Ala Val Val Ala Leu Val Tyr           
95                  100                 105                 110           

acc aca atg gct gag cac ttc ctg acg ttg ctg gta gtg cct gcc atc        505
Thr Thr Met Ala Glu His Phe Leu Thr Leu Leu Val Val Pro Ala Ile           
                115                 120                 125               

aag aaa gat tat ggt tcc cag gaa gac ttc act caa gtg tgg aac acc        553
Lys Lys Asp Tyr Gly Ser Gln Glu Asp Phe Thr Gln Val Trp Asn Thr           
            130                 135                 140                   

acc atg aaa ggg ctc aag tgc tgt ggc ttc acc aac tat acg gat ttt        601
Thr Met Lys Gly Leu Lys Cys Cys Gly Phe Thr Asn Tyr Thr Asp Phe           
        145                 150                 155                       

gag gac tca ccc tac ttc aaa gag aac agt gcc ttt ccc cca ttc tgt        649
Glu Asp Ser Pro Tyr Phe Lys Glu Asn Ser Ala Phe Pro Pro Phe Cys           
    160                 165                 170                           

tgc aat gac aac gtc acc aac aca gcc aat gaa acc tgc acc aag caa        697
Cys Asn Asp Asn Val Thr Asn Thr Ala Asn Glu Thr Cys Thr Lys Gln           
175                 180                 185                 190           

aag gct cac gac caa aaa gta gag ggt tgc ttc aat cag ctt ttg tat        745
Lys Ala His Asp Gln Lys Val Glu Gly Cys Phe Asn Gln Leu Leu Tyr           
                195                 200                 205               

gac atc cga act aat gca gtc acc gtg ggt ggt gtg gca gct gga att        793
Asp Ile Arg Thr Asn Ala Val Thr Val Gly Gly Val Ala Ala Gly Ile           
            210                 215                 220                   

ggg ggc ctc gag ctg gct gcc atg att gtg tcc atg tat ctg tac tgc        841
Gly Gly Leu Glu Leu Ala Ala Met Ile Val Ser Met Tyr Leu Tyr Cys           
        225                 230                 235                       

aat cta caa taa gtccacttct gcctctgcca ctactgctgc cacatgggaa            893
Asn Leu Gln                                                               
    240                                                                   

ctgtgaagag gcaccctggc aagcagcagt gattggggga ggggacagga tctaacaatg      953

tcacttgggc cagaatggac ctgccctttc tgctccagac ttggggctag atagggacca     1013

ctccttttag gcgatgcctg actttccttc cattggtggg tggatgggtg gggggcattc     1073

cagagcctct aaggtagcca gttctgttgc ccattccccc agtctattaa acccttgata     1133

tgccccctag gcctagtggt gatcccagtg ctctactggg ggatgagaga aaggcatttt     1193

atagcctggg cataagtgaa atcagcagag cctctgggtg gatgtgtaga aggcacttca     1253

aaatgcataa acctgttaca atgttaaaaa aaaaaaaaaa aaaa                      1297


<210>  56
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gln Cys Phe Ser Phe Ile Lys Thr Met Met Ile Leu Phe Asn Leu 
1               5                   10                  15      


Leu Ile Phe Leu Cys Gly Ala Ala Leu Leu Ala Val Gly Ile Trp Val 
            20                  25                  30          


Ser Ile Asp Gly Ala Ser Phe Leu Lys Ile Phe Gly Pro Leu Ser Ser 
        35                  40                  45              


Ser Ala Met Gln Phe Val Asn Val Gly Tyr Phe Leu Ile Ala Ala Gly 
    50                  55                  60                  


Val Val Val Phe Ala Leu Gly Phe Leu Gly Cys Tyr Gly Ala Lys Thr 
65                  70                  75                  80  


Glu Ser Lys Cys Ala Leu Val Thr Phe Phe Phe Ile Leu Leu Leu Ile 
                85                  90                  95      


Phe Ile Ala Glu Val Ala Ala Ala Val Val Ala Leu Val Tyr Thr Thr 
            100                 105                 110         


Met Ala Glu His Phe Leu Thr Leu Leu Val Val Pro Ala Ile Lys Lys 
        115                 120                 125             


Asp Tyr Gly Ser Gln Glu Asp Phe Thr Gln Val Trp Asn Thr Thr Met 
    130                 135                 140                 


Lys Gly Leu Lys Cys Cys Gly Phe Thr Asn Tyr Thr Asp Phe Glu Asp 
145                 150                 155                 160 


Ser Pro Tyr Phe Lys Glu Asn Ser Ala Phe Pro Pro Phe Cys Cys Asn 
                165                 170                 175     


Asp Asn Val Thr Asn Thr Ala Asn Glu Thr Cys Thr Lys Gln Lys Ala 
            180                 185                 190         


His Asp Gln Lys Val Glu Gly Cys Phe Asn Gln Leu Leu Tyr Asp Ile 
        195                 200                 205             


Arg Thr Asn Ala Val Thr Val Gly Gly Val Ala Ala Gly Ile Gly Gly 
    210                 215                 220                 


Leu Glu Leu Ala Ala Met Ile Val Ser Met Tyr Leu Tyr Cys Asn Leu 
225                 230                 235                 240 


Gln 
    


<210>  57
<211>  1206
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (143)..(727)

<400>  57
tacgcgcctt ggggtccggg tcggctttcc ccgggacccc tggccggaaa ctgagccgtt       60

cacttccgcc accagccgga agttttctgt cactggacgc caaggagttt tcggtggctc      120

agctgggtaa ccggggatca cc atg gcg gcc tca ttg gtg ggg aag aag atc       172
                         Met Ala Ala Ser Leu Val Gly Lys Lys Ile          
                         1               5                   10           

gtg ttt gta acg ggg aac gcc aag aag ctg gag gag gtc gtt cag att        220
Val Phe Val Thr Gly Asn Ala Lys Lys Leu Glu Glu Val Val Gln Ile           
                15                  20                  25                

cta gga gat aag ttt cca tgc act ttg gtg gca cag aaa att gac ctg        268
Leu Gly Asp Lys Phe Pro Cys Thr Leu Val Ala Gln Lys Ile Asp Leu           
            30                  35                  40                    

ccg gag tac cag ggg gag ccg gat gag att tcc ata cag aaa tgt cag        316
Pro Glu Tyr Gln Gly Glu Pro Asp Glu Ile Ser Ile Gln Lys Cys Gln           
        45                  50                  55                        

gag gca gtt cgc cag gta cag ggg ccc gtg ctg gtt gag gac act tgt        364
Glu Ala Val Arg Gln Val Gln Gly Pro Val Leu Val Glu Asp Thr Cys           
    60                  65                  70                            

ctg tgc ttc aat gcc ctt gga ggg ctc ccc ggc ccc tac ata aag tgg        412
Leu Cys Phe Asn Ala Leu Gly Gly Leu Pro Gly Pro Tyr Ile Lys Trp           
75                  80                  85                  90            

ttt ctg gag aag tta aag cct gaa ggt ctc cac cag ctc ctg gcc ggg        460
Phe Leu Glu Lys Leu Lys Pro Glu Gly Leu His Gln Leu Leu Ala Gly           
                95                  100                 105               

ttc gag gac aag tca gcc tat gcg ctc tgc acg ttt gca ctc agc acc        508
Phe Glu Asp Lys Ser Ala Tyr Ala Leu Cys Thr Phe Ala Leu Ser Thr           
            110                 115                 120                   

ggg gac cca agc cag ccc gtg cgc ctg ttc agg ggc cgg acc tcg ggc        556
Gly Asp Pro Ser Gln Pro Val Arg Leu Phe Arg Gly Arg Thr Ser Gly           
        125                 130                 135                       

cgg atc gtg gca ccc aga ggc tgc cag gac ttt ggc tgg gac ccc tgc        604
Arg Ile Val Ala Pro Arg Gly Cys Gln Asp Phe Gly Trp Asp Pro Cys           
    140                 145                 150                           

ttt cag cct gat gga tat gag cag acg tac gca gag atg cct aag gcg        652
Phe Gln Pro Asp Gly Tyr Glu Gln Thr Tyr Ala Glu Met Pro Lys Ala           
155                 160                 165                 170           

gag aag aac gct gtc tcc cat cgc ttc cgg gcc ctg ctg gag ctg cag        700
Glu Lys Asn Ala Val Ser His Arg Phe Arg Ala Leu Leu Glu Leu Gln           
                175                 180                 185               

gag tac ttt ggc agt ttg gca gct tga cttctgcagc tggaggaggc              747
Glu Tyr Phe Gly Ser Leu Ala Ala                                           
            190                                                           

ccctcaggcc ggggatctgg ggagggctag cccaaaacct cccgcatcgg gcaggcaccc      807

cctgaagtac ttccttcagg gtttcccctt tgtgagggtg tcgagtagcc tcaccggcct      867

gtctggagga gcagctggct ctgctctgag aaactctggc aagtggacgc cattctcttg      927

cccttaggat tcactgctct ctcctacagc cgccaggcct ggggtcctga aaggaccttg      987

ggtggtaaag ctgtacttgg tgggagtgag ggcgtgggga ggaaccatgc aaatcgcctt     1047

ccatggtttt taaatgcagt aaataacatt tctggatgag acttgtttcc aaaataaacc     1107

agctatatct gttttgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1167

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                            1206


<210>  58
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Ala Ser Leu Val Gly Lys Lys Ile Val Phe Val Thr Gly Asn 
1               5                   10                  15      


Ala Lys Lys Leu Glu Glu Val Val Gln Ile Leu Gly Asp Lys Phe Pro 
            20                  25                  30          


Cys Thr Leu Val Ala Gln Lys Ile Asp Leu Pro Glu Tyr Gln Gly Glu 
        35                  40                  45              


Pro Asp Glu Ile Ser Ile Gln Lys Cys Gln Glu Ala Val Arg Gln Val 
    50                  55                  60                  


Gln Gly Pro Val Leu Val Glu Asp Thr Cys Leu Cys Phe Asn Ala Leu 
65                  70                  75                  80  


Gly Gly Leu Pro Gly Pro Tyr Ile Lys Trp Phe Leu Glu Lys Leu Lys 
                85                  90                  95      


Pro Glu Gly Leu His Gln Leu Leu Ala Gly Phe Glu Asp Lys Ser Ala 
            100                 105                 110         


Tyr Ala Leu Cys Thr Phe Ala Leu Ser Thr Gly Asp Pro Ser Gln Pro 
        115                 120                 125             


Val Arg Leu Phe Arg Gly Arg Thr Ser Gly Arg Ile Val Ala Pro Arg 
    130                 135                 140                 


Gly Cys Gln Asp Phe Gly Trp Asp Pro Cys Phe Gln Pro Asp Gly Tyr 
145                 150                 155                 160 


Glu Gln Thr Tyr Ala Glu Met Pro Lys Ala Glu Lys Asn Ala Val Ser 
                165                 170                 175     


His Arg Phe Arg Ala Leu Leu Glu Leu Gln Glu Tyr Phe Gly Ser Leu 
            180                 185                 190         


Ala Ala 
        


<210>  59
<211>  972
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (19)..(969)

<400>  59
tttcctccga ttaaatta atg ttc caa act caa aag aaa aac aac tca gct         51
                    Met Phe Gln Thr Gln Lys Lys Asn Asn Ser Ala           
                    1               5                   10                

cag gca tca cct tgc ctg gaa ggc ttc cct agt cct cct gcc tcc cgc         99
Gln Ala Ser Pro Cys Leu Glu Gly Phe Pro Ser Pro Pro Ala Ser Arg           
            15                  20                  25                    

aga ctt gtc tgg cac cct gtg cat ttg gga ttt ggc aca cta tgt ctc        147
Arg Leu Val Trp His Pro Val His Leu Gly Phe Gly Thr Leu Cys Leu           
        30                  35                  40                        

atc tgc ggc ctc cac tgg acg atg aga cct gtt ctt ggg gaa gat ccc        195
Ile Cys Gly Leu His Trp Thr Met Arg Pro Val Leu Gly Glu Asp Pro           
    45                  50                  55                            

gac tta gcc att ttc cag tgg cac ctc ttc cac cat gag ttc ctg agg        243
Asp Leu Ala Ile Phe Gln Trp His Leu Phe His His Glu Phe Leu Arg           
60                  65                  70                  75            

cag tcc gat ggg gct act tta ttc cag aac aat cac agt gag acc ttt        291
Gln Ser Asp Gly Ala Thr Leu Phe Gln Asn Asn His Ser Glu Thr Phe           
                80                  85                  90                

tct ccc aat aaa tgc ccc ttt tct ctc ctt aat ata ttc tct tgc tta        339
Ser Pro Asn Lys Cys Pro Phe Ser Leu Leu Asn Ile Phe Ser Cys Leu           
            95                  100                 105                   

caa aac act ggt gtc tcc tta tca tgg att tcc ttt gtt ttg cct cct        387
Gln Asn Thr Gly Val Ser Leu Ser Trp Ile Ser Phe Val Leu Pro Pro           
        110                 115                 120                       

tgc ctg gtg ctt tca gcg agc agc gct gac gtc atc tca gga acc gtg        435
Cys Leu Val Leu Ser Ala Ser Ser Ala Asp Val Ile Ser Gly Thr Val           
    125                 130                 135                           

ctg cgt ctg aga gaa gaa cct gca gcc cag cga gca gca ccg gtg att        483
Leu Arg Leu Arg Glu Glu Pro Ala Ala Gln Arg Ala Ala Pro Val Ile           
140                 145                 150                 155           

gat gat act aca gcg cat ccc agg agc tgg tat ccc agg gca gcg ctg        531
Asp Asp Thr Thr Ala His Pro Arg Ser Trp Tyr Pro Arg Ala Ala Leu           
                160                 165                 170               

cac ctg ctg gca gcc aaa ccc ttc ggg gca gga cac cgg ccc aca gcc        579
His Leu Leu Ala Ala Lys Pro Phe Gly Ala Gly His Arg Pro Thr Ala           
            175                 180                 185                   

tcg gag cgc cca gtt cca acc atc aat ttt aat tct tgt gtg gtg tca        627
Ser Glu Arg Pro Val Pro Thr Ile Asn Phe Asn Ser Cys Val Val Ser           
        190                 195                 200                       

gca cag cgg cag gtc acc gtt cag gaa gga ccc ttg tac cgc acg gag        675
Ala Gln Arg Gln Val Thr Val Gln Glu Gly Pro Leu Tyr Arg Thr Glu           
    205                 210                 215                           

ggc tcc cac atc act atc tgg tgc aat gtg agt ggc tac cag gga cct        723
Gly Ser His Ile Thr Ile Trp Cys Asn Val Ser Gly Tyr Gln Gly Pro           
220                 225                 230                 235           

tct gaa cag aat ttc cag tgg tcc att tac ctg cct tcg tcg cca gag        771
Ser Glu Gln Asn Phe Gln Trp Ser Ile Tyr Leu Pro Ser Ser Pro Glu           
                240                 245                 250               

cga gag gtg cag atc gtc agc acc atg gac tct tcc ttc ccc tat gcc        819
Arg Glu Val Gln Ile Val Ser Thr Met Asp Ser Ser Phe Pro Tyr Ala           
            255                 260                 265                   

atc tac acc cag cgc gtc cgc gga ggg aag atc ttc ata gaa aga gtc        867
Ile Tyr Thr Gln Arg Val Arg Gly Gly Lys Ile Phe Ile Glu Arg Val           
        270                 275                 280                       

cag ggg aac cca acc cta ttg cac atc aca gat ctt cag gcc cgg gat        915
Gln Gly Asn Pro Thr Leu Leu His Ile Thr Asp Leu Gln Ala Arg Asp           
    285                 290                 295                           

gcc ggg gaa tat gaa tgc cac aca ccc agc acc gag aag caa tac ttt        963
Ala Gly Glu Tyr Glu Cys His Thr Pro Ser Thr Glu Lys Gln Tyr Phe           
300                 305                 310                 315           

ggg agt taa                                                            972
Gly Ser                                                                   
                                                                          


<210>  60
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Phe Gln Thr Gln Lys Lys Asn Asn Ser Ala Gln Ala Ser Pro Cys 
1               5                   10                  15      


Leu Glu Gly Phe Pro Ser Pro Pro Ala Ser Arg Arg Leu Val Trp His 
            20                  25                  30          


Pro Val His Leu Gly Phe Gly Thr Leu Cys Leu Ile Cys Gly Leu His 
        35                  40                  45              


Trp Thr Met Arg Pro Val Leu Gly Glu Asp Pro Asp Leu Ala Ile Phe 
    50                  55                  60                  


Gln Trp His Leu Phe His His Glu Phe Leu Arg Gln Ser Asp Gly Ala 
65                  70                  75                  80  


Thr Leu Phe Gln Asn Asn His Ser Glu Thr Phe Ser Pro Asn Lys Cys 
                85                  90                  95      


Pro Phe Ser Leu Leu Asn Ile Phe Ser Cys Leu Gln Asn Thr Gly Val 
            100                 105                 110         


Ser Leu Ser Trp Ile Ser Phe Val Leu Pro Pro Cys Leu Val Leu Ser 
        115                 120                 125             


Ala Ser Ser Ala Asp Val Ile Ser Gly Thr Val Leu Arg Leu Arg Glu 
    130                 135                 140                 


Glu Pro Ala Ala Gln Arg Ala Ala Pro Val Ile Asp Asp Thr Thr Ala 
145                 150                 155                 160 


His Pro Arg Ser Trp Tyr Pro Arg Ala Ala Leu His Leu Leu Ala Ala 
                165                 170                 175     


Lys Pro Phe Gly Ala Gly His Arg Pro Thr Ala Ser Glu Arg Pro Val 
            180                 185                 190         


Pro Thr Ile Asn Phe Asn Ser Cys Val Val Ser Ala Gln Arg Gln Val 
        195                 200                 205             


Thr Val Gln Glu Gly Pro Leu Tyr Arg Thr Glu Gly Ser His Ile Thr 
    210                 215                 220                 


Ile Trp Cys Asn Val Ser Gly Tyr Gln Gly Pro Ser Glu Gln Asn Phe 
225                 230                 235                 240 


Gln Trp Ser Ile Tyr Leu Pro Ser Ser Pro Glu Arg Glu Val Gln Ile 
                245                 250                 255     


Val Ser Thr Met Asp Ser Ser Phe Pro Tyr Ala Ile Tyr Thr Gln Arg 
            260                 265                 270         


Val Arg Gly Gly Lys Ile Phe Ile Glu Arg Val Gln Gly Asn Pro Thr 
        275                 280                 285             


Leu Leu His Ile Thr Asp Leu Gln Ala Arg Asp Ala Gly Glu Tyr Glu 
    290                 295                 300                 


Cys His Thr Pro Ser Thr Glu Lys Gln Tyr Phe Gly Ser 
305                 310                 315         


<210>  61
<211>  6246
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (415)..(5658)

<400>  61
gacttaaact ctggggcccg ggaggccgcc ggttttctcc ccgcttgccg gggtggtcct       60

cttccctttg tcggaccaaa gaagtaaaca ctgtgtggag agggactgac gtgtttggag      120

ggaaatggga atgtacacga taattaaaga gtaaagttgt gctcaacgct gtttacttct      180

aattatttcc tgattcacaa attaattttt gcaattcaca acttcaagaa tacttggact      240

attggattca atccatagta atctgcaaaa gaagagaagc agaattatac ctagaagtct      300

actaatggac agttagtcac ccacctacat gttgagattc ctgacattca gacaactgac      360

ttgtaactga cttataactg acttgtaata cactgctact atatcaaacc gaca atg        417
                                                            Met           
                                                            1             

aat tgg aat gaa aaa cca aag agt gct aca tta cca cca ctg tat cct        465
Asn Trp Asn Glu Lys Pro Lys Ser Ala Thr Leu Pro Pro Leu Tyr Pro           
            5                   10                  15                    

aaa agc cag cca cct ttt ttg cac cag tct tta ata aac caa att acc        513
Lys Ser Gln Pro Pro Phe Leu His Gln Ser Leu Ile Asn Gln Ile Thr           
        20                  25                  30                        

aca aca tct cag agt tct ttc agc tat cct gga agt aac caa gaa gca        561
Thr Thr Ser Gln Ser Ser Phe Ser Tyr Pro Gly Ser Asn Gln Glu Ala           
    35                  40                  45                            

tgc atg tat ccc ggt aat tca aat cca att tca cag cca ctg ctg aat        609
Cys Met Tyr Pro Gly Asn Ser Asn Pro Ile Ser Gln Pro Leu Leu Asn           
50                  55                  60                  65            

atc caa aat tat cct caa caa att tct gtt tct gat atg cat aat ggg        657
Ile Gln Asn Tyr Pro Gln Gln Ile Ser Val Ser Asp Met His Asn Gly           
                70                  75                  80                

aca gtt gtg gcc tca cac act tca gta gaa aga ata aca tat gca aat        705
Thr Val Val Ala Ser His Thr Ser Val Glu Arg Ile Thr Tyr Ala Asn           
            85                  90                  95                    

gtt aat gga ccc aaa caa cta act cac aat ttg cag atg tct tca gga        753
Val Asn Gly Pro Lys Gln Leu Thr His Asn Leu Gln Met Ser Ser Gly           
        100                 105                 110                       

gtt acc caa aat gta tgg ttg aac tca cca atg agg aat cct gtg cat        801
Val Thr Gln Asn Val Trp Leu Asn Ser Pro Met Arg Asn Pro Val His           
    115                 120                 125                           

tct cat ata ggg gca act gta tct cat caa act gat ttt gga gct aac        849
Ser His Ile Gly Ala Thr Val Ser His Gln Thr Asp Phe Gly Ala Asn           
130                 135                 140                 145           

gta ccc aat atg ccg gca cta cag agt caa ctg ata aca tca gat acc        897
Val Pro Asn Met Pro Ala Leu Gln Ser Gln Leu Ile Thr Ser Asp Thr           
                150                 155                 160               

tat tct atg caa atg cag atg atc cct tct aat tct aca cga ctt cct        945
Tyr Ser Met Gln Met Gln Met Ile Pro Ser Asn Ser Thr Arg Leu Pro           
            165                 170                 175                   

gta gct tac caa gga aat cag gga ctt aac cag tct ttt tca gag caa        993
Val Ala Tyr Gln Gly Asn Gln Gly Leu Asn Gln Ser Phe Ser Glu Gln           
        180                 185                 190                       

cag gtt gat tgg aca caa cag tgt ata tct aag gga ctg act tac cca       1041
Gln Val Asp Trp Thr Gln Gln Cys Ile Ser Lys Gly Leu Thr Tyr Pro           
    195                 200                 205                           

gat tac aga cca cct cca aag cta tac cgt tac tca cca caa agc ttt       1089
Asp Tyr Arg Pro Pro Pro Lys Leu Tyr Arg Tyr Ser Pro Gln Ser Phe           
210                 215                 220                 225           

tta cca gat tct acc att caa aaa caa aac ttt ata cca cat aca tca       1137
Leu Pro Asp Ser Thr Ile Gln Lys Gln Asn Phe Ile Pro His Thr Ser           
                230                 235                 240               

ttg caa gtt aaa aat agt cag ctt cca aat tct gta tta act tta cca       1185
Leu Gln Val Lys Asn Ser Gln Leu Pro Asn Ser Val Leu Thr Leu Pro           
            245                 250                 255                   

tca agg cag acc tca gct gta cca tca cag cag tat gcc acg caa act       1233
Ser Arg Gln Thr Ser Ala Val Pro Ser Gln Gln Tyr Ala Thr Gln Thr           
        260                 265                 270                       

gac aaa aga cct cct cct cct cct tac aac tgt aga tat gga agc cag       1281
Asp Lys Arg Pro Pro Pro Pro Pro Tyr Asn Cys Arg Tyr Gly Ser Gln           
    275                 280                 285                           

cct ttg caa agt act cag cat att act aaa cac ttg tct atg gaa gtt       1329
Pro Leu Gln Ser Thr Gln His Ile Thr Lys His Leu Ser Met Glu Val           
290                 295                 300                 305           

cct cag agt cga gaa atg ctg tca tct gaa ata agg acc agc ttt caa       1377
Pro Gln Ser Arg Glu Met Leu Ser Ser Glu Ile Arg Thr Ser Phe Gln           
                310                 315                 320               

cag cag tgg caa aac cct aat gaa aat gtc agc aca att gga aat ttc       1425
Gln Gln Trp Gln Asn Pro Asn Glu Asn Val Ser Thr Ile Gly Asn Phe           
            325                 330                 335                   

act aac ttg aaa gta aat acc aac agc aaa cag cct ttt aac agt ccc       1473
Thr Asn Leu Lys Val Asn Thr Asn Ser Lys Gln Pro Phe Asn Ser Pro           
        340                 345                 350                       

att aga tct tct gtg gat ggt gtt cag act ctt gct caa act aat gaa       1521
Ile Arg Ser Ser Val Asp Gly Val Gln Thr Leu Ala Gln Thr Asn Glu           
    355                 360                 365                           

gag aaa ata atg gat tct tgc aat cca act tca aat caa gta ctg gac       1569
Glu Lys Ile Met Asp Ser Cys Asn Pro Thr Ser Asn Gln Val Leu Asp           
370                 375                 380                 385           

aca agt gtt gca aaa gaa aag cta gta agg gat att aaa aca tta gta       1617
Thr Ser Val Ala Lys Glu Lys Leu Val Arg Asp Ile Lys Thr Leu Val           
                390                 395                 400               

gag ata aaa cag aag ttt tca gaa ctt gca agg aaa att aaa atc aat       1665
Glu Ile Lys Gln Lys Phe Ser Glu Leu Ala Arg Lys Ile Lys Ile Asn           
            405                 410                 415                   

aaa gat ctt ttg atg gca gca ggt tgt att aaa atg act aat act tct       1713
Lys Asp Leu Leu Met Ala Ala Gly Cys Ile Lys Met Thr Asn Thr Ser           
        420                 425                 430                       

tat agt gaa cca gct cag aat tct aaa ttg tct cta aaa caa act gcc       1761
Tyr Ser Glu Pro Ala Gln Asn Ser Lys Leu Ser Leu Lys Gln Thr Ala           
    435                 440                 445                           

aaa atc cag tct gga ccc cag ata act cca gta atg cca gag aat gca       1809
Lys Ile Gln Ser Gly Pro Gln Ile Thr Pro Val Met Pro Glu Asn Ala           
450                 455                 460                 465           

gag aga caa aca cca aca gta gtg gaa tct gca gaa aca aat aag act       1857
Glu Arg Gln Thr Pro Thr Val Val Glu Ser Ala Glu Thr Asn Lys Thr           
                470                 475                 480               

caa tgt atg ttg aat tct gac att cag gaa gtc aat tgc aga agg ttt       1905
Gln Cys Met Leu Asn Ser Asp Ile Gln Glu Val Asn Cys Arg Arg Phe           
            485                 490                 495                   

aac caa gtt gat tct gtt tta cca aat cct gtc tat tct gaa aag cgg       1953
Asn Gln Val Asp Ser Val Leu Pro Asn Pro Val Tyr Ser Glu Lys Arg           
        500                 505                 510                       

cca atg cca gac cca tct cat gat gtg aaa gtt ctc act tca aag aca       2001
Pro Met Pro Asp Pro Ser His Asp Val Lys Val Leu Thr Ser Lys Thr           
    515                 520                 525                           

tca gct gtt gag atg acc cag gca gta ttg aat act cag ctt tca tca       2049
Ser Ala Val Glu Met Thr Gln Ala Val Leu Asn Thr Gln Leu Ser Ser           
530                 535                 540                 545           

gaa aat gtt acc aaa gtt gag caa aat tca cca gca gtt tgt gaa aca       2097
Glu Asn Val Thr Lys Val Glu Gln Asn Ser Pro Ala Val Cys Glu Thr           
                550                 555                 560               

att tct gtt ccc aag tcc atg tcc act gag gaa tat aaa tca aaa att       2145
Ile Ser Val Pro Lys Ser Met Ser Thr Glu Glu Tyr Lys Ser Lys Ile           
            565                 570                 575                   

caa aat gaa aat atg cta ctt ctc gct ttg ctt tca cag gca cgt aag       2193
Gln Asn Glu Asn Met Leu Leu Leu Ala Leu Leu Ser Gln Ala Arg Lys           
        580                 585                 590                       

act cag aag aca gta tta aaa gat gct aat caa act att cag gat tct       2241
Thr Gln Lys Thr Val Leu Lys Asp Ala Asn Gln Thr Ile Gln Asp Ser           
    595                 600                 605                           

aaa cca gac agt tgt gaa atg aat cca aat acc caa atg act ggt aac       2289
Lys Pro Asp Ser Cys Glu Met Asn Pro Asn Thr Gln Met Thr Gly Asn           
610                 615                 620                 625           

caa ctg aat ttg aag aac atg gaa act cca agt act tct aat gta agt       2337
Gln Leu Asn Leu Lys Asn Met Glu Thr Pro Ser Thr Ser Asn Val Ser           
                630                 635                 640               

ggc agg gtt ttg gac aac tcc ttt tgc agt gga caa gaa tcc tca aca       2385
Gly Arg Val Leu Asp Asn Ser Phe Cys Ser Gly Gln Glu Ser Ser Thr           
            645                 650                 655                   

aaa gga atg cct gct aaa agt gac agt agc tgt tcc atg gaa gtg cta       2433
Lys Gly Met Pro Ala Lys Ser Asp Ser Ser Cys Ser Met Glu Val Leu           
        660                 665                 670                       

gca acc tgt ctt tcc ctg tgg aaa aag caa cct tca gat act gca aaa       2481
Ala Thr Cys Leu Ser Leu Trp Lys Lys Gln Pro Ser Asp Thr Ala Lys           
    675                 680                 685                           

gaa aag gag tgt gat aaa ctc aga aca aac aca aca gca gtt gga att       2529
Glu Lys Glu Cys Asp Lys Leu Arg Thr Asn Thr Thr Ala Val Gly Ile           
690                 695                 700                 705           

tca aag cct gct aac atc cac gtt aag agt cct tgt tca gtt gtg gga       2577
Ser Lys Pro Ala Asn Ile His Val Lys Ser Pro Cys Ser Val Val Gly           
                710                 715                 720               

aat tca aat tct cag aat aaa ata agt aat ccc tca cag cag aca gct       2625
Asn Ser Asn Ser Gln Asn Lys Ile Ser Asn Pro Ser Gln Gln Thr Ala           
            725                 730                 735                   

ttg tcg atg gta atg cac aat tat gag tct tca ggt ata aat ata aca       2673
Leu Ser Met Val Met His Asn Tyr Glu Ser Ser Gly Ile Asn Ile Thr           
        740                 745                 750                       

aag gga aca gaa ctt cag ata gct gta gtg tca ccg tta gtt ctg tca       2721
Lys Gly Thr Glu Leu Gln Ile Ala Val Val Ser Pro Leu Val Leu Ser           
    755                 760                 765                           

gag gtc aaa aca ttg tct gtc aaa gga ata aca cct gca gtg tta cct       2769
Glu Val Lys Thr Leu Ser Val Lys Gly Ile Thr Pro Ala Val Leu Pro           
770                 775                 780                 785           

gaa aca gtg tat ccc gtt att aaa gaa ggc agt gtt tgt agt tta caa       2817
Glu Thr Val Tyr Pro Val Ile Lys Glu Gly Ser Val Cys Ser Leu Gln           
                790                 795                 800               

aat caa ttg gca gaa aat gca aag gca act gct gct ttg aaa gtt gat       2865
Asn Gln Leu Ala Glu Asn Ala Lys Ala Thr Ala Ala Leu Lys Val Asp           
            805                 810                 815                   

gtt agt gga cca gta gca agt aca gca aca tca acc aag att ttt cca       2913
Val Ser Gly Pro Val Ala Ser Thr Ala Thr Ser Thr Lys Ile Phe Pro           
        820                 825                 830                       

cta act cag aag gaa aag cag aat gag tca act aat ggt aat tca gaa       2961
Leu Thr Gln Lys Glu Lys Gln Asn Glu Ser Thr Asn Gly Asn Ser Glu           
    835                 840                 845                           

gtc aca cct aat gtc aat caa gga aag cat aac aaa tta gag tca gct       3009
Val Thr Pro Asn Val Asn Gln Gly Lys His Asn Lys Leu Glu Ser Ala           
850                 855                 860                 865           

atc cat tct cct atg aac gat cag caa atc tca cag gag tca agg aat       3057
Ile His Ser Pro Met Asn Asp Gln Gln Ile Ser Gln Glu Ser Arg Asn           
                870                 875                 880               

agt act gtt gtg agt agt gat aca tta cag att gac aat att tgt tct       3105
Ser Thr Val Val Ser Ser Asp Thr Leu Gln Ile Asp Asn Ile Cys Ser           
            885                 890                 895                   

ctg gtt gaa ggt gat acc tct tac aat tcc caa ata gca aag ata ttc       3153
Leu Val Glu Gly Asp Thr Ser Tyr Asn Ser Gln Ile Ala Lys Ile Phe           
        900                 905                 910                       

agc tct ctt ccc ttg aaa atg gtt gag cca cag aaa cct tct cta ccc       3201
Ser Ser Leu Pro Leu Lys Met Val Glu Pro Gln Lys Pro Ser Leu Pro           
    915                 920                 925                           

aat cag caa ggg att ggc agc aga gaa cca gaa aaa caa tta gat aat       3249
Asn Gln Gln Gly Ile Gly Ser Arg Glu Pro Glu Lys Gln Leu Asp Asn           
930                 935                 940                 945           

acc act gaa aat aaa gac ttt ggt ttt caa aaa gat aaa cct gta cag       3297
Thr Thr Glu Asn Lys Asp Phe Gly Phe Gln Lys Asp Lys Pro Val Gln           
                950                 955                 960               

tgc aca gat gtt tca cat aaa ata tgt gat cag tca aag tca gag cca       3345
Cys Thr Asp Val Ser His Lys Ile Cys Asp Gln Ser Lys Ser Glu Pro           
            965                 970                 975                   

ccc tta gag tca tct ttt aac aat ctt gaa aca aac aga gtt att cta       3393
Pro Leu Glu Ser Ser Phe Asn Asn Leu Glu Thr Asn Arg Val Ile Leu           
        980                 985                 990                       

gag aaa agt agt ttg gag cat  gcc act gaa aaa agc  aca gct aac gat     3441
Glu Lys Ser Ser Leu Glu His  Ala Thr Glu Lys Ser  Thr Ala Asn Asp         
    995                 1000                 1005                         

acg  tgc tcg tca gct gct  att cag gag gat att  tac cct cag gaa        3486
Thr  Cys Ser Ser Ala Ala  Ile Gln Glu Asp Ile  Tyr Pro Gln Glu            
1010                 1015                 1020                            

ata  gat gca tcc agc aac  tat act ccc caa gat  cct gca aga aat        3531
Ile  Asp Ala Ser Ser Asn  Tyr Thr Pro Gln Asp  Pro Ala Arg Asn            
1025                 1030                 1035                            

gaa  atc cac agt gat aag  gca cct gtc tta tac  cta cat gac cag        3576
Glu  Ile His Ser Asp Lys  Ala Pro Val Leu Tyr  Leu His Asp Gln            
1040                 1045                 1050                            

ctg  tca gaa ctt cta aaa  gag ttt cct tat ggc  att gag gct gtg        3621
Leu  Ser Glu Leu Leu Lys  Glu Phe Pro Tyr Gly  Ile Glu Ala Val            
1055                 1060                 1065                            

aat  aca cgt gaa ggt tct  gtg ggc cag caa act  aca tac cag acc        3666
Asn  Thr Arg Glu Gly Ser  Val Gly Gln Gln Thr  Thr Tyr Gln Thr            
1070                 1075                 1080                            

tca  gaa gat caa act gct  gat aaa acc agt tct  gac tcc aaa gac        3711
Ser  Glu Asp Gln Thr Ala  Asp Lys Thr Ser Ser  Asp Ser Lys Asp            
1085                 1090                 1095                            

cca  gca gat caa ata caa  att aca ata tta agc  tca gag caa atg        3756
Pro  Ala Asp Gln Ile Gln  Ile Thr Ile Leu Ser  Ser Glu Gln Met            
1100                 1105                 1110                            

aaa  gaa ata ttt cct gaa  cag gat gat caa ccc  tat gta gta gac        3801
Lys  Glu Ile Phe Pro Glu  Gln Asp Asp Gln Pro  Tyr Val Val Asp            
1115                 1120                 1125                            

aag  ttg gca gaa cct cag  aaa gaa gag ccc atc  aca gaa gta gtt        3846
Lys  Leu Ala Glu Pro Gln  Lys Glu Glu Pro Ile  Thr Glu Val Val            
1130                 1135                 1140                            

agc  cag tgt gac ctg cag  gca cct gca gct gga  caa agt cgt gat        3891
Ser  Gln Cys Asp Leu Gln  Ala Pro Ala Ala Gly  Gln Ser Arg Asp            
1145                 1150                 1155                            

tct  gtg ata ctg gac tct  gag aaa gat gat atc  cac tgc tgt gca        3936
Ser  Val Ile Leu Asp Ser  Glu Lys Asp Asp Ile  His Cys Cys Ala            
1160                 1165                 1170                            

ttg  ggc tgg ctc tcc atg  gtt tac gaa gga gta  ccc cag tgt cag        3981
Leu  Gly Trp Leu Ser Met  Val Tyr Glu Gly Val  Pro Gln Cys Gln            
1175                 1180                 1185                            

tgt  aat tcc atc aag aac  tca tct tca gag gaa  gag aaa caa aaa        4026
Cys  Asn Ser Ile Lys Asn  Ser Ser Ser Glu Glu  Glu Lys Gln Lys            
1190                 1195                 1200                            

gag  cag tgt tct cct ttg  gat acc aac agt tgt  aaa caa gga gag        4071
Glu  Gln Cys Ser Pro Leu  Asp Thr Asn Ser Cys  Lys Gln Gly Glu            
1205                 1210                 1215                            

aga  act tct gat aga gat  gtc act gtt gtt caa  ttt aag agc ctt        4116
Arg  Thr Ser Asp Arg Asp  Val Thr Val Val Gln  Phe Lys Ser Leu            
1220                 1225                 1230                            

gta  aat aat cca aag act  cct cca gat ggg aaa  agt cat ttt cct        4161
Val  Asn Asn Pro Lys Thr  Pro Pro Asp Gly Lys  Ser His Phe Pro            
1235                 1240                 1245                            

gaa  cta caa gac gac agt  aga aaa gat aca ccc  aaa aca aaa cat        4206
Glu  Leu Gln Asp Asp Ser  Arg Lys Asp Thr Pro  Lys Thr Lys His            
1250                 1255                 1260                            

aaa  agc tta cca agg aca  gaa caa gaa tta gtt  gct ggt cag ttt        4251
Lys  Ser Leu Pro Arg Thr  Glu Gln Glu Leu Val  Ala Gly Gln Phe            
1265                 1270                 1275                            

tca  tct aaa tgt gat aaa  cta aat ccc ttg caa  aat cac aaa aga        4296
Ser  Ser Lys Cys Asp Lys  Leu Asn Pro Leu Gln  Asn His Lys Arg            
1280                 1285                 1290                            

aaa  aaa ttg agg ttt cac  gag gta acc ttt cac  tcc agt aat aaa        4341
Lys  Lys Leu Arg Phe His  Glu Val Thr Phe His  Ser Ser Asn Lys            
1295                 1300                 1305                            

atg  aca gca tct tat gaa  caa gct tct cag gaa  acc cga cag aag        4386
Met  Thr Ala Ser Tyr Glu  Gln Ala Ser Gln Glu  Thr Arg Gln Lys            
1310                 1315                 1320                            

aaa  cat gta aca cag aac  tca cgt cca cta aaa  aca aaa aca gct        4431
Lys  His Val Thr Gln Asn  Ser Arg Pro Leu Lys  Thr Lys Thr Ala            
1325                 1330                 1335                            

ttt  ttg cca aat aaa gat  gtg tat aag aag cat  agt tct ttg gga        4476
Phe  Leu Pro Asn Lys Asp  Val Tyr Lys Lys His  Ser Ser Leu Gly            
1340                 1345                 1350                            

cag  tca tta tca cca gaa  aag ata aaa ttg aaa  ctc aaa tca gtt        4521
Gln  Ser Leu Ser Pro Glu  Lys Ile Lys Leu Lys  Leu Lys Ser Val            
1355                 1360                 1365                            

agc  ttc aaa caa aaa cga  aag tta gac caa ggg  aac gta tta gat        4566
Ser  Phe Lys Gln Lys Arg  Lys Leu Asp Gln Gly  Asn Val Leu Asp            
1370                 1375                 1380                            

atg  gaa gta aag aaa aag  aaa cat gat aaa caa  gaa cag aaa gga        4611
Met  Glu Val Lys Lys Lys  Lys His Asp Lys Gln  Glu Gln Lys Gly            
1385                 1390                 1395                            

agt  gtg gga gct aca ttc  aaa tta ggt gac tct  ttg tca aac cca        4656
Ser  Val Gly Ala Thr Phe  Lys Leu Gly Asp Ser  Leu Ser Asn Pro            
1400                 1405                 1410                            

aac  gaa aga gcc att gtt  aaa gaa aag atg gta  tca aat act aag        4701
Asn  Glu Arg Ala Ile Val  Lys Glu Lys Met Val  Ser Asn Thr Lys            
1415                 1420                 1425                            

tct  gta gac acg aaa gcg  agt tca tct aaa ttt  agt aga att cta        4746
Ser  Val Asp Thr Lys Ala  Ser Ser Ser Lys Phe  Ser Arg Ile Leu            
1430                 1435                 1440                            

act  cct aag gag tat tta  caa agg cag aag cat  aaa gaa gct ctg        4791
Thr  Pro Lys Glu Tyr Leu  Gln Arg Gln Lys His  Lys Glu Ala Leu            
1445                 1450                 1455                            

agt  aat aaa gca tcg aag  aaa atc tgt gtg aaa  aac gtg cca tgt        4836
Ser  Asn Lys Ala Ser Lys  Lys Ile Cys Val Lys  Asn Val Pro Cys            
1460                 1465                 1470                            

gat  tct gaa cat atg aga  cca agt aaa ctt gcc  gtg cag gtt gaa        4881
Asp  Ser Glu His Met Arg  Pro Ser Lys Leu Ala  Val Gln Val Glu            
1475                 1480                 1485                            

agt  tgt ggg aaa tca aat  gag aaa cac agc agc  ggc gtg cag acc        4926
Ser  Cys Gly Lys Ser Asn  Glu Lys His Ser Ser  Gly Val Gln Thr            
1490                 1495                 1500                            

tct  aaa gaa tca tta aat  ggc ttg aca agc cat  ggt aaa aac ctc        4971
Ser  Lys Glu Ser Leu Asn  Gly Leu Thr Ser His  Gly Lys Asn Leu            
1505                 1510                 1515                            

aaa  atc cac cat tct cag  gag tct aaa aca tac  aac att cta agg        5016
Lys  Ile His His Ser Gln  Glu Ser Lys Thr Tyr  Asn Ile Leu Arg            
1520                 1525                 1530                            

aat  gtt aaa gaa aaa gtt  ggt ggg aag cag cct  gat aaa ata tgg        5061
Asn  Val Lys Glu Lys Val  Gly Gly Lys Gln Pro  Asp Lys Ile Trp            
1535                 1540                 1545                            

att  gat aag act aaa tta  gac aaa tta acc aat  ata agc aac gaa        5106
Ile  Asp Lys Thr Lys Leu  Asp Lys Leu Thr Asn  Ile Ser Asn Glu            
1550                 1555                 1560                            

gct  caa ttc agc caa atg  cct ccc caa gta aag  gat caa aag aaa        5151
Ala  Gln Phe Ser Gln Met  Pro Pro Gln Val Lys  Asp Gln Lys Lys            
1565                 1570                 1575                            

tta  tat ctg aat aga gtt  ggg ttt aaa tgc act  gaa cgt gaa agc        5196
Leu  Tyr Leu Asn Arg Val  Gly Phe Lys Cys Thr  Glu Arg Glu Ser            
1580                 1585                 1590                            

att  tct ctc acc aaa tta  gaa agt tca ccc agg  aag ctt cat aaa        5241
Ile  Ser Leu Thr Lys Leu  Glu Ser Ser Pro Arg  Lys Leu His Lys            
1595                 1600                 1605                            

gat  aag aga cag gaa aat  aaa cat aag acc ttt  tta ccg gtg aaa        5286
Asp  Lys Arg Gln Glu Asn  Lys His Lys Thr Phe  Leu Pro Val Lys            
1610                 1615                 1620                            

ggt  aac aca gaa aaa tca  aac atg ctg gag ttt  aaa tta tgt cca        5331
Gly  Asn Thr Glu Lys Ser  Asn Met Leu Glu Phe  Lys Leu Cys Pro            
1625                 1630                 1635                            

gat  atc tta cta aag aat  aca aac tct gtg gaa  gaa cgg aag gat        5376
Asp  Ile Leu Leu Lys Asn  Thr Asn Ser Val Glu  Glu Arg Lys Asp            
1640                 1645                 1650                            

gta  aag cct cat cct agg  aag gag caa gcc cct  ctg caa gtt tca        5421
Val  Lys Pro His Pro Arg  Lys Glu Gln Ala Pro  Leu Gln Val Ser            
1655                 1660                 1665                            

gga  ata aaa agt aca aaa  gaa gac tgg tta aaa  ttt gtt gct aca        5466
Gly  Ile Lys Ser Thr Lys  Glu Asp Trp Leu Lys  Phe Val Ala Thr            
1670                 1675                 1680                            

aag  aaa agg aca cag aaa  gac agc caa gag aga  gat aat gtt aat        5511
Lys  Lys Arg Thr Gln Lys  Asp Ser Gln Glu Arg  Asp Asn Val Asn            
1685                 1690                 1695                            

tca  aga ctc tcg aag aga  agc ttc agt gca gat  gga ttt gag atg        5556
Ser  Arg Leu Ser Lys Arg  Ser Phe Ser Ala Asp  Gly Phe Glu Met            
1700                 1705                 1710                            

cta  caa aac cca gta aaa  gat tca aaa gaa atg  ttt caa acc tac        5601
Leu  Gln Asn Pro Val Lys  Asp Ser Lys Glu Met  Phe Gln Thr Tyr            
1715                 1720                 1725                            

aaa  cag atg tac ctg gag  aag aga agc aga agc  ctt ggt agc agt        5646
Lys  Gln Met Tyr Leu Glu  Lys Arg Ser Arg Ser  Leu Gly Ser Ser            
1730                 1735                 1740                            

cct  gta aaa taa ttacaagatg tggttttgta attgccactg ggaaatttct          5698
Pro  Val Lys                                                              
1745                                                                      

ttccttttct gttcaaaata tttcgctgaa actaatgaga aatgccatga taaagatttc     5758

tcagagtttg gttcccactt tcattgtatt tcattgaaag tgcttaatta aaatggcttg     5818

agaactttgg gtagccatgt gtaagaaatg gatggtattc accggggaaa caaggtattt     5878

gaatttctac tttattgaac cagatttacc attattttaa aaggaatgct tatacaaatc     5938

aatttgaaat tctacccatc ttgagggagg accgttcctc agttaaggac ttgtttattt     5998

aaatgggact gtaaatatgt tttggtttct aagctatatt agcaaaattt atttttcaaa     6058

aatgcccact gtgatgtgaa tgtcaaaata tattcttaag tgttttataa ctaattgtaa     6118

actttttttc agaagtctta ttttatactt gtgaaactga acacaatttt gggacaacgt     6178

ttaaacatta cttttcatac ttgaaataaa catttatttt ttaaaaaact aaaaaaaaaa     6238

aaaaaaaa                                                              6246


<210>  62
<211>  1747
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Asn Trp Asn Glu Lys Pro Lys Ser Ala Thr Leu Pro Pro Leu Tyr 
1               5                   10                  15      


Pro Lys Ser Gln Pro Pro Phe Leu His Gln Ser Leu Ile Asn Gln Ile 
            20                  25                  30          


Thr Thr Thr Ser Gln Ser Ser Phe Ser Tyr Pro Gly Ser Asn Gln Glu 
        35                  40                  45              


Ala Cys Met Tyr Pro Gly Asn Ser Asn Pro Ile Ser Gln Pro Leu Leu 
    50                  55                  60                  


Asn Ile Gln Asn Tyr Pro Gln Gln Ile Ser Val Ser Asp Met His Asn 
65                  70                  75                  80  


Gly Thr Val Val Ala Ser His Thr Ser Val Glu Arg Ile Thr Tyr Ala 
                85                  90                  95      


Asn Val Asn Gly Pro Lys Gln Leu Thr His Asn Leu Gln Met Ser Ser 
            100                 105                 110         


Gly Val Thr Gln Asn Val Trp Leu Asn Ser Pro Met Arg Asn Pro Val 
        115                 120                 125             


His Ser His Ile Gly Ala Thr Val Ser His Gln Thr Asp Phe Gly Ala 
    130                 135                 140                 


Asn Val Pro Asn Met Pro Ala Leu Gln Ser Gln Leu Ile Thr Ser Asp 
145                 150                 155                 160 


Thr Tyr Ser Met Gln Met Gln Met Ile Pro Ser Asn Ser Thr Arg Leu 
                165                 170                 175     


Pro Val Ala Tyr Gln Gly Asn Gln Gly Leu Asn Gln Ser Phe Ser Glu 
            180                 185                 190         


Gln Gln Val Asp Trp Thr Gln Gln Cys Ile Ser Lys Gly Leu Thr Tyr 
        195                 200                 205             


Pro Asp Tyr Arg Pro Pro Pro Lys Leu Tyr Arg Tyr Ser Pro Gln Ser 
    210                 215                 220                 


Phe Leu Pro Asp Ser Thr Ile Gln Lys Gln Asn Phe Ile Pro His Thr 
225                 230                 235                 240 


Ser Leu Gln Val Lys Asn Ser Gln Leu Pro Asn Ser Val Leu Thr Leu 
                245                 250                 255     


Pro Ser Arg Gln Thr Ser Ala Val Pro Ser Gln Gln Tyr Ala Thr Gln 
            260                 265                 270         


Thr Asp Lys Arg Pro Pro Pro Pro Pro Tyr Asn Cys Arg Tyr Gly Ser 
        275                 280                 285             


Gln Pro Leu Gln Ser Thr Gln His Ile Thr Lys His Leu Ser Met Glu 
    290                 295                 300                 


Val Pro Gln Ser Arg Glu Met Leu Ser Ser Glu Ile Arg Thr Ser Phe 
305                 310                 315                 320 


Gln Gln Gln Trp Gln Asn Pro Asn Glu Asn Val Ser Thr Ile Gly Asn 
                325                 330                 335     


Phe Thr Asn Leu Lys Val Asn Thr Asn Ser Lys Gln Pro Phe Asn Ser 
            340                 345                 350         


Pro Ile Arg Ser Ser Val Asp Gly Val Gln Thr Leu Ala Gln Thr Asn 
        355                 360                 365             


Glu Glu Lys Ile Met Asp Ser Cys Asn Pro Thr Ser Asn Gln Val Leu 
    370                 375                 380                 


Asp Thr Ser Val Ala Lys Glu Lys Leu Val Arg Asp Ile Lys Thr Leu 
385                 390                 395                 400 


Val Glu Ile Lys Gln Lys Phe Ser Glu Leu Ala Arg Lys Ile Lys Ile 
                405                 410                 415     


Asn Lys Asp Leu Leu Met Ala Ala Gly Cys Ile Lys Met Thr Asn Thr 
            420                 425                 430         


Ser Tyr Ser Glu Pro Ala Gln Asn Ser Lys Leu Ser Leu Lys Gln Thr 
        435                 440                 445             


Ala Lys Ile Gln Ser Gly Pro Gln Ile Thr Pro Val Met Pro Glu Asn 
    450                 455                 460                 


Ala Glu Arg Gln Thr Pro Thr Val Val Glu Ser Ala Glu Thr Asn Lys 
465                 470                 475                 480 


Thr Gln Cys Met Leu Asn Ser Asp Ile Gln Glu Val Asn Cys Arg Arg 
                485                 490                 495     


Phe Asn Gln Val Asp Ser Val Leu Pro Asn Pro Val Tyr Ser Glu Lys 
            500                 505                 510         


Arg Pro Met Pro Asp Pro Ser His Asp Val Lys Val Leu Thr Ser Lys 
        515                 520                 525             


Thr Ser Ala Val Glu Met Thr Gln Ala Val Leu Asn Thr Gln Leu Ser 
    530                 535                 540                 


Ser Glu Asn Val Thr Lys Val Glu Gln Asn Ser Pro Ala Val Cys Glu 
545                 550                 555                 560 


Thr Ile Ser Val Pro Lys Ser Met Ser Thr Glu Glu Tyr Lys Ser Lys 
                565                 570                 575     


Ile Gln Asn Glu Asn Met Leu Leu Leu Ala Leu Leu Ser Gln Ala Arg 
            580                 585                 590         


Lys Thr Gln Lys Thr Val Leu Lys Asp Ala Asn Gln Thr Ile Gln Asp 
        595                 600                 605             


Ser Lys Pro Asp Ser Cys Glu Met Asn Pro Asn Thr Gln Met Thr Gly 
    610                 615                 620                 


Asn Gln Leu Asn Leu Lys Asn Met Glu Thr Pro Ser Thr Ser Asn Val 
625                 630                 635                 640 


Ser Gly Arg Val Leu Asp Asn Ser Phe Cys Ser Gly Gln Glu Ser Ser 
                645                 650                 655     


Thr Lys Gly Met Pro Ala Lys Ser Asp Ser Ser Cys Ser Met Glu Val 
            660                 665                 670         


Leu Ala Thr Cys Leu Ser Leu Trp Lys Lys Gln Pro Ser Asp Thr Ala 
        675                 680                 685             


Lys Glu Lys Glu Cys Asp Lys Leu Arg Thr Asn Thr Thr Ala Val Gly 
    690                 695                 700                 


Ile Ser Lys Pro Ala Asn Ile His Val Lys Ser Pro Cys Ser Val Val 
705                 710                 715                 720 


Gly Asn Ser Asn Ser Gln Asn Lys Ile Ser Asn Pro Ser Gln Gln Thr 
                725                 730                 735     


Ala Leu Ser Met Val Met His Asn Tyr Glu Ser Ser Gly Ile Asn Ile 
            740                 745                 750         


Thr Lys Gly Thr Glu Leu Gln Ile Ala Val Val Ser Pro Leu Val Leu 
        755                 760                 765             


Ser Glu Val Lys Thr Leu Ser Val Lys Gly Ile Thr Pro Ala Val Leu 
    770                 775                 780                 


Pro Glu Thr Val Tyr Pro Val Ile Lys Glu Gly Ser Val Cys Ser Leu 
785                 790                 795                 800 


Gln Asn Gln Leu Ala Glu Asn Ala Lys Ala Thr Ala Ala Leu Lys Val 
                805                 810                 815     


Asp Val Ser Gly Pro Val Ala Ser Thr Ala Thr Ser Thr Lys Ile Phe 
            820                 825                 830         


Pro Leu Thr Gln Lys Glu Lys Gln Asn Glu Ser Thr Asn Gly Asn Ser 
        835                 840                 845             


Glu Val Thr Pro Asn Val Asn Gln Gly Lys His Asn Lys Leu Glu Ser 
    850                 855                 860                 


Ala Ile His Ser Pro Met Asn Asp Gln Gln Ile Ser Gln Glu Ser Arg 
865                 870                 875                 880 


Asn Ser Thr Val Val Ser Ser Asp Thr Leu Gln Ile Asp Asn Ile Cys 
                885                 890                 895     


Ser Leu Val Glu Gly Asp Thr Ser Tyr Asn Ser Gln Ile Ala Lys Ile 
            900                 905                 910         


Phe Ser Ser Leu Pro Leu Lys Met Val Glu Pro Gln Lys Pro Ser Leu 
        915                 920                 925             


Pro Asn Gln Gln Gly Ile Gly Ser Arg Glu Pro Glu Lys Gln Leu Asp 
    930                 935                 940                 


Asn Thr Thr Glu Asn Lys Asp Phe Gly Phe Gln Lys Asp Lys Pro Val 
945                 950                 955                 960 


Gln Cys Thr Asp Val Ser His Lys Ile Cys Asp Gln Ser Lys Ser Glu 
                965                 970                 975     


Pro Pro Leu Glu Ser Ser Phe Asn Asn Leu Glu Thr Asn Arg Val Ile 
            980                 985                 990         


Leu Glu Lys Ser Ser Leu Glu His  Ala Thr Glu Lys Ser  Thr Ala Asn 
        995                 1000                 1005             


Asp Thr  Cys Ser Ser Ala Ala  Ile Gln Glu Asp Ile  Tyr Pro Gln 
    1010                 1015                 1020             


Glu Ile  Asp Ala Ser Ser Asn  Tyr Thr Pro Gln Asp  Pro Ala Arg 
    1025                 1030                 1035             


Asn Glu  Ile His Ser Asp Lys  Ala Pro Val Leu Tyr  Leu His Asp 
    1040                 1045                 1050             


Gln Leu  Ser Glu Leu Leu Lys  Glu Phe Pro Tyr Gly  Ile Glu Ala 
    1055                 1060                 1065             


Val Asn  Thr Arg Glu Gly Ser  Val Gly Gln Gln Thr  Thr Tyr Gln 
    1070                 1075                 1080             


Thr Ser  Glu Asp Gln Thr Ala  Asp Lys Thr Ser Ser  Asp Ser Lys 
    1085                 1090                 1095             


Asp Pro  Ala Asp Gln Ile Gln  Ile Thr Ile Leu Ser  Ser Glu Gln 
    1100                 1105                 1110             


Met Lys  Glu Ile Phe Pro Glu  Gln Asp Asp Gln Pro  Tyr Val Val 
    1115                 1120                 1125             


Asp Lys  Leu Ala Glu Pro Gln  Lys Glu Glu Pro Ile  Thr Glu Val 
    1130                 1135                 1140             


Val Ser  Gln Cys Asp Leu Gln  Ala Pro Ala Ala Gly  Gln Ser Arg 
    1145                 1150                 1155             


Asp Ser  Val Ile Leu Asp Ser  Glu Lys Asp Asp Ile  His Cys Cys 
    1160                 1165                 1170             


Ala Leu  Gly Trp Leu Ser Met  Val Tyr Glu Gly Val  Pro Gln Cys 
    1175                 1180                 1185             


Gln Cys  Asn Ser Ile Lys Asn  Ser Ser Ser Glu Glu  Glu Lys Gln 
    1190                 1195                 1200             


Lys Glu  Gln Cys Ser Pro Leu  Asp Thr Asn Ser Cys  Lys Gln Gly 
    1205                 1210                 1215             


Glu Arg  Thr Ser Asp Arg Asp  Val Thr Val Val Gln  Phe Lys Ser 
    1220                 1225                 1230             


Leu Val  Asn Asn Pro Lys Thr  Pro Pro Asp Gly Lys  Ser His Phe 
    1235                 1240                 1245             


Pro Glu  Leu Gln Asp Asp Ser  Arg Lys Asp Thr Pro  Lys Thr Lys 
    1250                 1255                 1260             


His Lys  Ser Leu Pro Arg Thr  Glu Gln Glu Leu Val  Ala Gly Gln 
    1265                 1270                 1275             


Phe Ser  Ser Lys Cys Asp Lys  Leu Asn Pro Leu Gln  Asn His Lys 
    1280                 1285                 1290             


Arg Lys  Lys Leu Arg Phe His  Glu Val Thr Phe His  Ser Ser Asn 
    1295                 1300                 1305             


Lys Met  Thr Ala Ser Tyr Glu  Gln Ala Ser Gln Glu  Thr Arg Gln 
    1310                 1315                 1320             


Lys Lys  His Val Thr Gln Asn  Ser Arg Pro Leu Lys  Thr Lys Thr 
    1325                 1330                 1335             


Ala Phe  Leu Pro Asn Lys Asp  Val Tyr Lys Lys His  Ser Ser Leu 
    1340                 1345                 1350             


Gly Gln  Ser Leu Ser Pro Glu  Lys Ile Lys Leu Lys  Leu Lys Ser 
    1355                 1360                 1365             


Val Ser  Phe Lys Gln Lys Arg  Lys Leu Asp Gln Gly  Asn Val Leu 
    1370                 1375                 1380             


Asp Met  Glu Val Lys Lys Lys  Lys His Asp Lys Gln  Glu Gln Lys 
    1385                 1390                 1395             


Gly Ser  Val Gly Ala Thr Phe  Lys Leu Gly Asp Ser  Leu Ser Asn 
    1400                 1405                 1410             


Pro Asn  Glu Arg Ala Ile Val  Lys Glu Lys Met Val  Ser Asn Thr 
    1415                 1420                 1425             


Lys Ser  Val Asp Thr Lys Ala  Ser Ser Ser Lys Phe  Ser Arg Ile 
    1430                 1435                 1440             


Leu Thr  Pro Lys Glu Tyr Leu  Gln Arg Gln Lys His  Lys Glu Ala 
    1445                 1450                 1455             


Leu Ser  Asn Lys Ala Ser Lys  Lys Ile Cys Val Lys  Asn Val Pro 
    1460                 1465                 1470             


Cys Asp  Ser Glu His Met Arg  Pro Ser Lys Leu Ala  Val Gln Val 
    1475                 1480                 1485             


Glu Ser  Cys Gly Lys Ser Asn  Glu Lys His Ser Ser  Gly Val Gln 
    1490                 1495                 1500             


Thr Ser  Lys Glu Ser Leu Asn  Gly Leu Thr Ser His  Gly Lys Asn 
    1505                 1510                 1515             


Leu Lys  Ile His His Ser Gln  Glu Ser Lys Thr Tyr  Asn Ile Leu 
    1520                 1525                 1530             


Arg Asn  Val Lys Glu Lys Val  Gly Gly Lys Gln Pro  Asp Lys Ile 
    1535                 1540                 1545             


Trp Ile  Asp Lys Thr Lys Leu  Asp Lys Leu Thr Asn  Ile Ser Asn 
    1550                 1555                 1560             


Glu Ala  Gln Phe Ser Gln Met  Pro Pro Gln Val Lys  Asp Gln Lys 
    1565                 1570                 1575             


Lys Leu  Tyr Leu Asn Arg Val  Gly Phe Lys Cys Thr  Glu Arg Glu 
    1580                 1585                 1590             


Ser Ile  Ser Leu Thr Lys Leu  Glu Ser Ser Pro Arg  Lys Leu His 
    1595                 1600                 1605             


Lys Asp  Lys Arg Gln Glu Asn  Lys His Lys Thr Phe  Leu Pro Val 
    1610                 1615                 1620             


Lys Gly  Asn Thr Glu Lys Ser  Asn Met Leu Glu Phe  Lys Leu Cys 
    1625                 1630                 1635             


Pro Asp  Ile Leu Leu Lys Asn  Thr Asn Ser Val Glu  Glu Arg Lys 
    1640                 1645                 1650             


Asp Val  Lys Pro His Pro Arg  Lys Glu Gln Ala Pro  Leu Gln Val 
    1655                 1660                 1665             


Ser Gly  Ile Lys Ser Thr Lys  Glu Asp Trp Leu Lys  Phe Val Ala 
    1670                 1675                 1680             


Thr Lys  Lys Arg Thr Gln Lys  Asp Ser Gln Glu Arg  Asp Asn Val 
    1685                 1690                 1695             


Asn Ser  Arg Leu Ser Lys Arg  Ser Phe Ser Ala Asp  Gly Phe Glu 
    1700                 1705                 1710             


Met Leu  Gln Asn Pro Val Lys  Asp Ser Lys Glu Met  Phe Gln Thr 
    1715                 1720                 1725             


Tyr Lys  Gln Met Tyr Leu Glu  Lys Arg Ser Arg Ser  Leu Gly Ser 
    1730                 1735                 1740             


Ser Pro  Val Lys 
    1745         


<210>  63
<211>  3302
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (177)..(2585)

<400>  63
gctatataag gcggcgtgag gcaggcgagg ggggcagcgc agccgagcgg agcccaggag       60

agcagagagc gagcctgagc gagagacggg gaagcacgga ggaggaagcc gccggtgcgt      120

cgggacggga gcgcaggtgc tcgggcaccc gagctggagc tccgcagccg ccggtc atg      179
                                                              Met         
                                                              1           

tac cgc tcc acc aag ggc gcc tcc aag gcg cgc cgg gac cag atc aac        227
Tyr Arg Ser Thr Lys Gly Ala Ser Lys Ala Arg Arg Asp Gln Ile Asn           
            5                   10                  15                    

gcc gag atc cgg aac ctc aag gag ctg ctg ccg ctg gcc gaa gcg gac        275
Ala Glu Ile Arg Asn Leu Lys Glu Leu Leu Pro Leu Ala Glu Ala Asp           
        20                  25                  30                        

aag gtc cgg ctg tcc tac ctg cac atc atg agc ctc gcc tgc atc tac        323
Lys Val Arg Leu Ser Tyr Leu His Ile Met Ser Leu Ala Cys Ile Tyr           
    35                  40                  45                            

act cgc aag ggc gtc ttc ttc gct ggt ggc act cct ctg gcg ggc ccc        371
Thr Arg Lys Gly Val Phe Phe Ala Gly Gly Thr Pro Leu Ala Gly Pro           
50                  55                  60                  65            

acg ggg ctt ctc tca gct caa gag ctt gag gac atc gta gcg gca cta        419
Thr Gly Leu Leu Ser Ala Gln Glu Leu Glu Asp Ile Val Ala Ala Leu           
                70                  75                  80                

ccc ggc ttt ctg ctt gtg ttc aca gcc gag ggg aaa ttg ctc tac ctg        467
Pro Gly Phe Leu Leu Val Phe Thr Ala Glu Gly Lys Leu Leu Tyr Leu           
            85                  90                  95                    

tct gag agt gtg agc gag cat ctg ggc cac tcc atg gtg gac ctg gtt        515
Ser Glu Ser Val Ser Glu His Leu Gly His Ser Met Val Asp Leu Val           
        100                 105                 110                       

gcc cag ggt gac agc atc tac gac atc att gac cca gct gac cac ctc        563
Ala Gln Gly Asp Ser Ile Tyr Asp Ile Ile Asp Pro Ala Asp His Leu           
    115                 120                 125                           

act gtg cgc cag caa ctc acc ctg ccc tct gcc ctg gac act gat cgc        611
Thr Val Arg Gln Gln Leu Thr Leu Pro Ser Ala Leu Asp Thr Asp Arg           
130                 135                 140                 145           

ctc ttc cgc tgc cgc ttc aac acc tcc aag tcc ctc agg cgc cag agt        659
Leu Phe Arg Cys Arg Phe Asn Thr Ser Lys Ser Leu Arg Arg Gln Ser           
                150                 155                 160               

gca ggc aac aaa ctc gtg ctt att cga ggc cga ttc cat gct cac cca        707
Ala Gly Asn Lys Leu Val Leu Ile Arg Gly Arg Phe His Ala His Pro           
            165                 170                 175                   

cct gga gcc tac tgg gca gga aat ccc gtg ttc aca gct ttc tgt gcc        755
Pro Gly Ala Tyr Trp Ala Gly Asn Pro Val Phe Thr Ala Phe Cys Ala           
        180                 185                 190                       

cct ctg gag ccg aga ccc cgc cca ggt cct ggc cct ggc cct ggc cct        803
Pro Leu Glu Pro Arg Pro Arg Pro Gly Pro Gly Pro Gly Pro Gly Pro           
    195                 200                 205                           

gcc tcg ctc ttc ctg gcc atg ttc cag agc cgc cat gct aaa gac ctg        851
Ala Ser Leu Phe Leu Ala Met Phe Gln Ser Arg His Ala Lys Asp Leu           
210                 215                 220                 225           

gct cta ctg gac atc tcc gag agt gtc cta atc tac ctg ggc ttt gag        899
Ala Leu Leu Asp Ile Ser Glu Ser Val Leu Ile Tyr Leu Gly Phe Glu           
                230                 235                 240               

cgc agt gaa ctg ctt tgt aaa tca tgg tat gga ctg ctg cac ccc gag        947
Arg Ser Glu Leu Leu Cys Lys Ser Trp Tyr Gly Leu Leu His Pro Glu           
            245                 250                 255                   

gac ctg gcc cac gct tct gct caa cac tac cgc ctg ttg gct gag agt        995
Asp Leu Ala His Ala Ser Ala Gln His Tyr Arg Leu Leu Ala Glu Ser           
        260                 265                 270                       

gga gat att cag gca gag atg gtg gtg agg cta cag gcc aag act gga       1043
Gly Asp Ile Gln Ala Glu Met Val Val Arg Leu Gln Ala Lys Thr Gly           
    275                 280                 285                           

ggc tgg gca tgg att tac tgc ctg tta tac tca gaa ggt cca gag gga       1091
Gly Trp Ala Trp Ile Tyr Cys Leu Leu Tyr Ser Glu Gly Pro Glu Gly           
290                 295                 300                 305           

ccc att act gcc aat aac tac cca atc agt gac atg gaa gcc tgg agc       1139
Pro Ile Thr Ala Asn Asn Tyr Pro Ile Ser Asp Met Glu Ala Trp Ser           
                310                 315                 320               

ctc cgc cag cag ttg aac tct gaa gac acc cag gca gct tat gtc ctg       1187
Leu Arg Gln Gln Leu Asn Ser Glu Asp Thr Gln Ala Ala Tyr Val Leu           
            325                 330                 335                   

ggc act ccg acc atg ctg ccc tca ttc cct gaa aac att ctt tcc cag       1235
Gly Thr Pro Thr Met Leu Pro Ser Phe Pro Glu Asn Ile Leu Ser Gln           
        340                 345                 350                       

gaa gag tgc tcc agc act aac cca ctc ttc acc gca gca ctg ggg gct       1283
Glu Glu Cys Ser Ser Thr Asn Pro Leu Phe Thr Ala Ala Leu Gly Ala           
    355                 360                 365                           

ccc aga agc acc agc ttc ccc agt gct cct gaa ctg agt gtt gtc tct       1331
Pro Arg Ser Thr Ser Phe Pro Ser Ala Pro Glu Leu Ser Val Val Ser           
370                 375                 380                 385           

gca tca gaa gag ctt ccc cga ccc tcc aaa gaa ctg gac ttc agt tac       1379
Ala Ser Glu Glu Leu Pro Arg Pro Ser Lys Glu Leu Asp Phe Ser Tyr           
                390                 395                 400               

ctg aca ttc cct tct ggg cct gag cct tct ctc caa gca gaa cta agc       1427
Leu Thr Phe Pro Ser Gly Pro Glu Pro Ser Leu Gln Ala Glu Leu Ser           
            405                 410                 415                   

aag gat ctt gtg tgc act cca cct tac acg ccc cat cag cca gga ggc       1475
Lys Asp Leu Val Cys Thr Pro Pro Tyr Thr Pro His Gln Pro Gly Gly           
        420                 425                 430                       

tgt gcc ttc ctc ttc agc ctc cat gag ccc ttc cag acc cat ttg ccc       1523
Cys Ala Phe Leu Phe Ser Leu His Glu Pro Phe Gln Thr His Leu Pro           
    435                 440                 445                           

acc cca tcc agc act ctt caa gaa cag ctg act cca agc act gcg acc       1571
Thr Pro Ser Ser Thr Leu Gln Glu Gln Leu Thr Pro Ser Thr Ala Thr           
450                 455                 460                 465           

ttc tct gat cag ttg acg ccc agc agt gca acc ttc cca gat cca cta       1619
Phe Ser Asp Gln Leu Thr Pro Ser Ser Ala Thr Phe Pro Asp Pro Leu           
                470                 475                 480               

act agc cca ctg caa ggc cag ttg act gaa acc tcg gtc aga agc tat       1667
Thr Ser Pro Leu Gln Gly Gln Leu Thr Glu Thr Ser Val Arg Ser Tyr           
            485                 490                 495                   

gaa gac cag ttg act ccc tgc acc tcc acc ttc cca gac cag ctg ctt       1715
Glu Asp Gln Leu Thr Pro Cys Thr Ser Thr Phe Pro Asp Gln Leu Leu           
        500                 505                 510                       

ccc agc aca gcc acc ttc cca gag cct ctg ggc agc cct gcc cat gaa       1763
Pro Ser Thr Ala Thr Phe Pro Glu Pro Leu Gly Ser Pro Ala His Glu           
    515                 520                 525                           

cag ctg act cct ccc agc aca gca ttc caa gca cac ctg gac agc ccc       1811
Gln Leu Thr Pro Pro Ser Thr Ala Phe Gln Ala His Leu Asp Ser Pro           
530                 535                 540                 545           

agc caa acc ttc cca gag caa ctg agc ccc aac cct acc aag act tac       1859
Ser Gln Thr Phe Pro Glu Gln Leu Ser Pro Asn Pro Thr Lys Thr Tyr           
                550                 555                 560               

ttt gcc cag gag gga tgc agt ttt ctc tat gag aag ttg ccc cca agt       1907
Phe Ala Gln Glu Gly Cys Ser Phe Leu Tyr Glu Lys Leu Pro Pro Ser           
            565                 570                 575                   

cct agc agc cct ggt aat ggg gac tgc acg ctc ttg gcc cta gcc cag       1955
Pro Ser Ser Pro Gly Asn Gly Asp Cys Thr Leu Leu Ala Leu Ala Gln           
        580                 585                 590                       

ctc cgg ggc ccc ctc tct gtg gat gtc ccc ctg gtg ccc gaa ggc ctg       2003
Leu Arg Gly Pro Leu Ser Val Asp Val Pro Leu Val Pro Glu Gly Leu           
    595                 600                 605                           

ctc aca cct gag gcc tct cca gtc aag cag agt ttc ttc cac tac tct       2051
Leu Thr Pro Glu Ala Ser Pro Val Lys Gln Ser Phe Phe His Tyr Ser           
610                 615                 620                 625           

gaa aag gag cag aat gag ata gac cgt ctc atc cag cag att agc caa       2099
Glu Lys Glu Gln Asn Glu Ile Asp Arg Leu Ile Gln Gln Ile Ser Gln           
                630                 635                 640               

ttg gct cag ggc atg gac aga ccc ttc tca gct gag gct ggc act ggc       2147
Leu Ala Gln Gly Met Asp Arg Pro Phe Ser Ala Glu Ala Gly Thr Gly           
            645                 650                 655                   

gga cta gag cca ctt gga gga ctg gag ccc ctg gac tcc aac ctg tcc       2195
Gly Leu Glu Pro Leu Gly Gly Leu Glu Pro Leu Asp Ser Asn Leu Ser           
        660                 665                 670                       

ctg tca ggg gca ggc ccc cct gtg ctc agc ctg gac ctg aaa ccc tgg       2243
Leu Ser Gly Ala Gly Pro Pro Val Leu Ser Leu Asp Leu Lys Pro Trp           
    675                 680                 685                           

aaa tgc cag gag ctg gac ttc ctg gct gac cct gat aac atg ttc ctg       2291
Lys Cys Gln Glu Leu Asp Phe Leu Ala Asp Pro Asp Asn Met Phe Leu           
690                 695                 700                 705           

gaa gag acg ccc gtg gaa gac atc ttc atg gat ctc tct acc cca gat       2339
Glu Glu Thr Pro Val Glu Asp Ile Phe Met Asp Leu Ser Thr Pro Asp           
                710                 715                 720               

ccc agt gag gaa tgg ggc tca ggg gat cct gag gca gag ggc cca gga       2387
Pro Ser Glu Glu Trp Gly Ser Gly Asp Pro Glu Ala Glu Gly Pro Gly           
            725                 730                 735                   

ggg gcc cca tcg cct tgc aac aac ctg tcc cca gaa gac cac agc ttc       2435
Gly Ala Pro Ser Pro Cys Asn Asn Leu Ser Pro Glu Asp His Ser Phe           
        740                 745                 750                       

ctg gag gac ctg gcc aca tat gaa acc gcc ttt gag aca ggt gtc tca       2483
Leu Glu Asp Leu Ala Thr Tyr Glu Thr Ala Phe Glu Thr Gly Val Ser           
    755                 760                 765                           

gca ttc ccc tat gat ggg ttt act gat gag ttg cat caa ctc cag agc       2531
Ala Phe Pro Tyr Asp Gly Phe Thr Asp Glu Leu His Gln Leu Gln Ser           
770                 775                 780                 785           

caa gtt caa gac agc ttc cat gaa gat gga agt gga ggg gaa cca acg       2579
Gln Val Gln Asp Ser Phe His Glu Asp Gly Ser Gly Gly Glu Pro Thr           
                790                 795                 800               

ttt tga ataagtctgt gacttaacgt cgtcaagtat ggcatattgt catcaagacg        2635
Phe                                                                       
                                                                          

tggagccgct ctccaccccc ccgggactgt tggggggatt ctgagggcca gagggggata     2695

tatatgattc cccaggccct gcaggatttt gggggggggg aggtgggagg gcaagggagg     2755

ggagcttctt tttaaaatca agagacttcg agcgatccca gtttccattt caatctgtat     2815

tcactcgtag tgagtttcct tgaatgggat ttcaagcgga gaatggggga gtctcacttc     2875

cccgccgcct tgccccattg gcctgggcca gttctccact cctaggggcc aagccacccc     2935

tagccttggt gggggaaagg cagggcccac ccgggccagc ccgtgccctg aggggctctt     2995

gacacccacg tagaattctc tacacaccag taacgggatt tcaattccga tggactctgc     3055

cgccctggcg gcccttcctg tgacttttgc gccccgcgcc tggggtgggg ggtgcgaaga     3115

gacgctacgt tcctttccga tggaggaagg cagacctgcc gtcacacgtg tgcttgcacg     3175

agtgcgtgta cctggtgcgg gactcacccg gccgccagac tgcctgggcc tgcccagatg     3235

gccacctcgt ggtgctgcgg tgactttgta gccaacttta taataaagtc cagtttgcct     3295

ttttggt                                                               3302


<210>  64
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Tyr Arg Ser Thr Lys Gly Ala Ser Lys Ala Arg Arg Asp Gln Ile 
1               5                   10                  15      


Asn Ala Glu Ile Arg Asn Leu Lys Glu Leu Leu Pro Leu Ala Glu Ala 
            20                  25                  30          


Asp Lys Val Arg Leu Ser Tyr Leu His Ile Met Ser Leu Ala Cys Ile 
        35                  40                  45              


Tyr Thr Arg Lys Gly Val Phe Phe Ala Gly Gly Thr Pro Leu Ala Gly 
    50                  55                  60                  


Pro Thr Gly Leu Leu Ser Ala Gln Glu Leu Glu Asp Ile Val Ala Ala 
65                  70                  75                  80  


Leu Pro Gly Phe Leu Leu Val Phe Thr Ala Glu Gly Lys Leu Leu Tyr 
                85                  90                  95      


Leu Ser Glu Ser Val Ser Glu His Leu Gly His Ser Met Val Asp Leu 
            100                 105                 110         


Val Ala Gln Gly Asp Ser Ile Tyr Asp Ile Ile Asp Pro Ala Asp His 
        115                 120                 125             


Leu Thr Val Arg Gln Gln Leu Thr Leu Pro Ser Ala Leu Asp Thr Asp 
    130                 135                 140                 


Arg Leu Phe Arg Cys Arg Phe Asn Thr Ser Lys Ser Leu Arg Arg Gln 
145                 150                 155                 160 


Ser Ala Gly Asn Lys Leu Val Leu Ile Arg Gly Arg Phe His Ala His 
                165                 170                 175     


Pro Pro Gly Ala Tyr Trp Ala Gly Asn Pro Val Phe Thr Ala Phe Cys 
            180                 185                 190         


Ala Pro Leu Glu Pro Arg Pro Arg Pro Gly Pro Gly Pro Gly Pro Gly 
        195                 200                 205             


Pro Ala Ser Leu Phe Leu Ala Met Phe Gln Ser Arg His Ala Lys Asp 
    210                 215                 220                 


Leu Ala Leu Leu Asp Ile Ser Glu Ser Val Leu Ile Tyr Leu Gly Phe 
225                 230                 235                 240 


Glu Arg Ser Glu Leu Leu Cys Lys Ser Trp Tyr Gly Leu Leu His Pro 
                245                 250                 255     


Glu Asp Leu Ala His Ala Ser Ala Gln His Tyr Arg Leu Leu Ala Glu 
            260                 265                 270         


Ser Gly Asp Ile Gln Ala Glu Met Val Val Arg Leu Gln Ala Lys Thr 
        275                 280                 285             


Gly Gly Trp Ala Trp Ile Tyr Cys Leu Leu Tyr Ser Glu Gly Pro Glu 
    290                 295                 300                 


Gly Pro Ile Thr Ala Asn Asn Tyr Pro Ile Ser Asp Met Glu Ala Trp 
305                 310                 315                 320 


Ser Leu Arg Gln Gln Leu Asn Ser Glu Asp Thr Gln Ala Ala Tyr Val 
                325                 330                 335     


Leu Gly Thr Pro Thr Met Leu Pro Ser Phe Pro Glu Asn Ile Leu Ser 
            340                 345                 350         


Gln Glu Glu Cys Ser Ser Thr Asn Pro Leu Phe Thr Ala Ala Leu Gly 
        355                 360                 365             


Ala Pro Arg Ser Thr Ser Phe Pro Ser Ala Pro Glu Leu Ser Val Val 
    370                 375                 380                 


Ser Ala Ser Glu Glu Leu Pro Arg Pro Ser Lys Glu Leu Asp Phe Ser 
385                 390                 395                 400 


Tyr Leu Thr Phe Pro Ser Gly Pro Glu Pro Ser Leu Gln Ala Glu Leu 
                405                 410                 415     


Ser Lys Asp Leu Val Cys Thr Pro Pro Tyr Thr Pro His Gln Pro Gly 
            420                 425                 430         


Gly Cys Ala Phe Leu Phe Ser Leu His Glu Pro Phe Gln Thr His Leu 
        435                 440                 445             


Pro Thr Pro Ser Ser Thr Leu Gln Glu Gln Leu Thr Pro Ser Thr Ala 
    450                 455                 460                 


Thr Phe Ser Asp Gln Leu Thr Pro Ser Ser Ala Thr Phe Pro Asp Pro 
465                 470                 475                 480 


Leu Thr Ser Pro Leu Gln Gly Gln Leu Thr Glu Thr Ser Val Arg Ser 
                485                 490                 495     


Tyr Glu Asp Gln Leu Thr Pro Cys Thr Ser Thr Phe Pro Asp Gln Leu 
            500                 505                 510         


Leu Pro Ser Thr Ala Thr Phe Pro Glu Pro Leu Gly Ser Pro Ala His 
        515                 520                 525             


Glu Gln Leu Thr Pro Pro Ser Thr Ala Phe Gln Ala His Leu Asp Ser 
    530                 535                 540                 


Pro Ser Gln Thr Phe Pro Glu Gln Leu Ser Pro Asn Pro Thr Lys Thr 
545                 550                 555                 560 


Tyr Phe Ala Gln Glu Gly Cys Ser Phe Leu Tyr Glu Lys Leu Pro Pro 
                565                 570                 575     


Ser Pro Ser Ser Pro Gly Asn Gly Asp Cys Thr Leu Leu Ala Leu Ala 
            580                 585                 590         


Gln Leu Arg Gly Pro Leu Ser Val Asp Val Pro Leu Val Pro Glu Gly 
        595                 600                 605             


Leu Leu Thr Pro Glu Ala Ser Pro Val Lys Gln Ser Phe Phe His Tyr 
    610                 615                 620                 


Ser Glu Lys Glu Gln Asn Glu Ile Asp Arg Leu Ile Gln Gln Ile Ser 
625                 630                 635                 640 


Gln Leu Ala Gln Gly Met Asp Arg Pro Phe Ser Ala Glu Ala Gly Thr 
                645                 650                 655     


Gly Gly Leu Glu Pro Leu Gly Gly Leu Glu Pro Leu Asp Ser Asn Leu 
            660                 665                 670         


Ser Leu Ser Gly Ala Gly Pro Pro Val Leu Ser Leu Asp Leu Lys Pro 
        675                 680                 685             


Trp Lys Cys Gln Glu Leu Asp Phe Leu Ala Asp Pro Asp Asn Met Phe 
    690                 695                 700                 


Leu Glu Glu Thr Pro Val Glu Asp Ile Phe Met Asp Leu Ser Thr Pro 
705                 710                 715                 720 


Asp Pro Ser Glu Glu Trp Gly Ser Gly Asp Pro Glu Ala Glu Gly Pro 
                725                 730                 735     


Gly Gly Ala Pro Ser Pro Cys Asn Asn Leu Ser Pro Glu Asp His Ser 
            740                 745                 750         


Phe Leu Glu Asp Leu Ala Thr Tyr Glu Thr Ala Phe Glu Thr Gly Val 
        755                 760                 765             


Ser Ala Phe Pro Tyr Asp Gly Phe Thr Asp Glu Leu His Gln Leu Gln 
    770                 775                 780                 


Ser Gln Val Gln Asp Ser Phe His Glu Asp Gly Ser Gly Gly Glu Pro 
785                 790                 795                 800 


Thr Phe 
        


<210>  65
<211>  466
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (91)..(276)

<400>  65
cttgccgcgc tgcactccac cacgcctcct ccaagtccca gcgaacccgc gtgcaacctg       60

tcccgactct agccgcctct tcagctcgcc atg gat ccc aac tgc tcc tgc gcc       114
                                 Met Asp Pro Asn Cys Ser Cys Ala          
                                 1               5                        

gcc ggt gac tcc tgc acc tgc gcc ggc tcc tgc aaa tgc aaa gag tgc        162
Ala Gly Asp Ser Cys Thr Cys Ala Gly Ser Cys Lys Cys Lys Glu Cys           
    10                  15                  20                            

aaa tgc acc tcc tgc aag aaa agc tgc tgc tcc tgc tgc cct gtg ggc        210
Lys Cys Thr Ser Cys Lys Lys Ser Cys Cys Ser Cys Cys Pro Val Gly           
25                  30                  35                  40            

tgt gcc aag tgt gcc cag ggc tgc atc tgc aaa ggg gcg tcg gac aag        258
Cys Ala Lys Cys Ala Gln Gly Cys Ile Cys Lys Gly Ala Ser Asp Lys           
                45                  50                  55                

tgc agc tgc tgc gcc tga tgctgggaca gccccgctcc cagatgtaaa               306
Cys Ser Cys Cys Ala                                                       
            60                                                            

gaacgcgact tccacaaacc tggatttttt atgtacaacc ctgaccgtga ccgtttgcta      366

tattcctttt tctatgaaat aatgtgaatg ataataaaac agctttgact tgaaaaaaaa      426

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                            466


<210>  66
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Asp Ser Cys Thr Cys Ala 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Ile Cys Lys Gly Ala Ser Asp Lys Cys Ser Cys Cys Ala 
    50                  55                  60      


<210>  67
<211>  2038
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (4)..(1971)

<400>  67
gcc atg ggg cgc tgg gcc tgg gtc ccc agc ccc tgg ccc cca ccg ggg         48
    Met Gly Arg Trp Ala Trp Val Pro Ser Pro Trp Pro Pro Pro Gly           
    1               5                   10                  15            

ctg ggc ccc ttc ctc ctc ctc ctc ctg ctg ctg ctg ctg ctg cca cgg         96
Leu Gly Pro Phe Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Arg           
                20                  25                  30                

ggg ttc cag ccc cag cct ggc ggg aac cgt acg gag tcc cca gaa cct        144
Gly Phe Gln Pro Gln Pro Gly Gly Asn Arg Thr Glu Ser Pro Glu Pro           
            35                  40                  45                    

aat gcc aca gcg acc cct gcg atc ccc act atc ctg gtg acc tct gtg        192
Asn Ala Thr Ala Thr Pro Ala Ile Pro Thr Ile Leu Val Thr Ser Val           
        50                  55                  60                        

acc tct gag acc cca gca aca agt gct cca gag gca gag gga ccc caa        240
Thr Ser Glu Thr Pro Ala Thr Ser Ala Pro Glu Ala Glu Gly Pro Gln           
    65                  70                  75                            

agt ggg ggg ctc ccg ccc ccg ccc agg gca gtt ccc tcg agc agt agc        288
Ser Gly Gly Leu Pro Pro Pro Pro Arg Ala Val Pro Ser Ser Ser Ser           
80                  85                  90                  95            

ccc cag gcc caa gca ctc acc gag gac ggg agg ccc tgc agg ttc ccc        336
Pro Gln Ala Gln Ala Leu Thr Glu Asp Gly Arg Pro Cys Arg Phe Pro           
                100                 105                 110               

ttc cgc tac ggg ggc cgc atg ctg cat gcc tgc act tcg gag ggc agt        384
Phe Arg Tyr Gly Gly Arg Met Leu His Ala Cys Thr Ser Glu Gly Ser           
            115                 120                 125                   

gca cac agg aag tgg tgt gcc aca act cac aac tac gac cgg gac agg        432
Ala His Arg Lys Trp Cys Ala Thr Thr His Asn Tyr Asp Arg Asp Arg           
        130                 135                 140                       

gcc tgg ggc tac tgt gtg gag gcc acc ccg cct cca ggg ggc cca gct        480
Ala Trp Gly Tyr Cys Val Glu Ala Thr Pro Pro Pro Gly Gly Pro Ala           
    145                 150                 155                           

gcc ctg gat ccc tgt gcc tcc ggc ccc tgc ctc aat gga ggc tcc tgc        528
Ala Leu Asp Pro Cys Ala Ser Gly Pro Cys Leu Asn Gly Gly Ser Cys           
160                 165                 170                 175           

tcc aat acc cag gac ccc cag tcc tat cac tgc agc tgc ccc cgg gcc        576
Ser Asn Thr Gln Asp Pro Gln Ser Tyr His Cys Ser Cys Pro Arg Ala           
                180                 185                 190               

ttc acc ggc aag gac tgc ggc aca gag aaa tgc ttt gat gag acc cgc        624
Phe Thr Gly Lys Asp Cys Gly Thr Glu Lys Cys Phe Asp Glu Thr Arg           
            195                 200                 205                   

tac gag tac ctg gag ggg ggc gac cgc tgg gcc cgc gtg cgc cag ggc        672
Tyr Glu Tyr Leu Glu Gly Gly Asp Arg Trp Ala Arg Val Arg Gln Gly           
        210                 215                 220                       

cac gtg gaa cag tgc gag tgc ttc ggg ggc cgg acc tgg tgc gaa ggc        720
His Val Glu Gln Cys Glu Cys Phe Gly Gly Arg Thr Trp Cys Glu Gly           
    225                 230                 235                           

acc cga cat aca gct tgt ctg agc agc cct tgc ctg aac ggg ggc acc        768
Thr Arg His Thr Ala Cys Leu Ser Ser Pro Cys Leu Asn Gly Gly Thr           
240                 245                 250                 255           

tgc cac ctg atc gtg gcc acc ggg acc acc gtg tgt gcc tgc cca cca        816
Cys His Leu Ile Val Ala Thr Gly Thr Thr Val Cys Ala Cys Pro Pro           
                260                 265                 270               

ggc ttc gct gga cgg ctc tgc aac atc gag cct gat gag cgc tgc ttc        864
Gly Phe Ala Gly Arg Leu Cys Asn Ile Glu Pro Asp Glu Arg Cys Phe           
            275                 280                 285                   

ttg ggg aac ggc act ggg tac cgt ggc gtg gcc agc acc tca gcc tcg        912
Leu Gly Asn Gly Thr Gly Tyr Arg Gly Val Ala Ser Thr Ser Ala Ser           
        290                 295                 300                       

ggc ctc agc tgc ctg gcc tgg aac tcc gat ctg ctc tac cag gag ctg        960
Gly Leu Ser Cys Leu Ala Trp Asn Ser Asp Leu Leu Tyr Gln Glu Leu           
    305                 310                 315                           

cac gtg gac tcc gtg ggc gcc gcg gcc ctg ctg ggc ctg ggc ccc cat       1008
His Val Asp Ser Val Gly Ala Ala Ala Leu Leu Gly Leu Gly Pro His           
320                 325                 330                 335           

gcc tac tgc cgg aat ccg gac aat gac gag agg ccc tgg tgc tac gtg       1056
Ala Tyr Cys Arg Asn Pro Asp Asn Asp Glu Arg Pro Trp Cys Tyr Val           
                340                 345                 350               

gtg aag gac agc gcg ctc tcc tgg gag tac tgc cgc ctg gag gcc tgc       1104
Val Lys Asp Ser Ala Leu Ser Trp Glu Tyr Cys Arg Leu Glu Ala Cys           
            355                 360                 365                   

gaa tcc ctc acc aga gtc caa ctg tca ccg gat ctc ctg gcg acc ctg       1152
Glu Ser Leu Thr Arg Val Gln Leu Ser Pro Asp Leu Leu Ala Thr Leu           
        370                 375                 380                       

cct gag cca gcc tcc ccg ggg cgc cag gcc tgc ggc agg agg cac aag       1200
Pro Glu Pro Ala Ser Pro Gly Arg Gln Ala Cys Gly Arg Arg His Lys           
    385                 390                 395                           

aag agg acg ttc ctg cgg cca cgt atc atc ggc ggc tcc tcc tcg ctg       1248
Lys Arg Thr Phe Leu Arg Pro Arg Ile Ile Gly Gly Ser Ser Ser Leu           
400                 405                 410                 415           

ccc ggc tcg cac ccc tgg ctg gcc gcc atc tac atc ggg gac agc ttc       1296
Pro Gly Ser His Pro Trp Leu Ala Ala Ile Tyr Ile Gly Asp Ser Phe           
                420                 425                 430               

tgc gcc ggg agc ctg gtc cac acc tgc tgg gtg gtg tcg gcc gcc cac       1344
Cys Ala Gly Ser Leu Val His Thr Cys Trp Val Val Ser Ala Ala His           
            435                 440                 445                   

tgc ttc tcc cac agc ccc ccc agg gac agc gtc tcc gtg gtg ctg ggc       1392
Cys Phe Ser His Ser Pro Pro Arg Asp Ser Val Ser Val Val Leu Gly           
        450                 455                 460                       

cag cac ttc ttc aac cgc acg acg gac gtg acg cag acc ttc ggc atc       1440
Gln His Phe Phe Asn Arg Thr Thr Asp Val Thr Gln Thr Phe Gly Ile           
    465                 470                 475                           

gag aag tac atc ccg tac acc ctg tac tcg gtg ttc aac ccc agc gac       1488
Glu Lys Tyr Ile Pro Tyr Thr Leu Tyr Ser Val Phe Asn Pro Ser Asp           
480                 485                 490                 495           

cac gac ctc gtc ctg atc cgg ctg aag aag aaa ggg gac cgc tgt gcc       1536
His Asp Leu Val Leu Ile Arg Leu Lys Lys Lys Gly Asp Arg Cys Ala           
                500                 505                 510               

aca cgc tcg cag ttc gtg cag ccc atc tgc ctg ccc gag ccc ggc agc       1584
Thr Arg Ser Gln Phe Val Gln Pro Ile Cys Leu Pro Glu Pro Gly Ser           
            515                 520                 525                   

acc ttc ccc gca gga cac aag tgc cag att gcg ggc tgg ggc cac ttg       1632
Thr Phe Pro Ala Gly His Lys Cys Gln Ile Ala Gly Trp Gly His Leu           
        530                 535                 540                       

gat gag aac gtg agc ggc tac tcc agc tcc ctg cgg gag gcc ctg gtc       1680
Asp Glu Asn Val Ser Gly Tyr Ser Ser Ser Leu Arg Glu Ala Leu Val           
    545                 550                 555                           

ccc ctg gtc gcc gac cac aag tgc agc agc cct gag gtc tac ggc gcc       1728
Pro Leu Val Ala Asp His Lys Cys Ser Ser Pro Glu Val Tyr Gly Ala           
560                 565                 570                 575           

gac atc agc ccc aac atg ctc tgt gcc ggc tac ttc gac tgc aag tcc       1776
Asp Ile Ser Pro Asn Met Leu Cys Ala Gly Tyr Phe Asp Cys Lys Ser           
                580                 585                 590               

gac gcc tgc cag ggg gac tca ggg ggg ccc ctg gcc tgc gag aag aac       1824
Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Ala Cys Glu Lys Asn           
            595                 600                 605                   

ggc gtg gct tac ctc tac ggc atc atc agc tgg ggt gac ggc tgc ggg       1872
Gly Val Ala Tyr Leu Tyr Gly Ile Ile Ser Trp Gly Asp Gly Cys Gly           
        610                 615                 620                       

cgg ctc cac aag ccg ggg gtc tac acc cgc gtg gcc aac tat gtg gac       1920
Arg Leu His Lys Pro Gly Val Tyr Thr Arg Val Ala Asn Tyr Val Asp           
    625                 630                 635                           

tgg atc aac gac cgg ata cgg cct ccc agg cgg ctt gtg gct ccc tcc       1968
Trp Ile Asn Asp Arg Ile Arg Pro Pro Arg Arg Leu Val Ala Pro Ser           
640                 645                 650                 655           

tga ccctccagcg ggacaccctg gttcccacca ttccctgcct tgctgacaat            2021

aaagatattt ccaagaa                                                    2038


<210>  68
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Gly Arg Trp Ala Trp Val Pro Ser Pro Trp Pro Pro Pro Gly Leu 
1               5                   10                  15      


Gly Pro Phe Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Arg Gly 
            20                  25                  30          


Phe Gln Pro Gln Pro Gly Gly Asn Arg Thr Glu Ser Pro Glu Pro Asn 
        35                  40                  45              


Ala Thr Ala Thr Pro Ala Ile Pro Thr Ile Leu Val Thr Ser Val Thr 
    50                  55                  60                  


Ser Glu Thr Pro Ala Thr Ser Ala Pro Glu Ala Glu Gly Pro Gln Ser 
65                  70                  75                  80  


Gly Gly Leu Pro Pro Pro Pro Arg Ala Val Pro Ser Ser Ser Ser Pro 
                85                  90                  95      


Gln Ala Gln Ala Leu Thr Glu Asp Gly Arg Pro Cys Arg Phe Pro Phe 
            100                 105                 110         


Arg Tyr Gly Gly Arg Met Leu His Ala Cys Thr Ser Glu Gly Ser Ala 
        115                 120                 125             


His Arg Lys Trp Cys Ala Thr Thr His Asn Tyr Asp Arg Asp Arg Ala 
    130                 135                 140                 


Trp Gly Tyr Cys Val Glu Ala Thr Pro Pro Pro Gly Gly Pro Ala Ala 
145                 150                 155                 160 


Leu Asp Pro Cys Ala Ser Gly Pro Cys Leu Asn Gly Gly Ser Cys Ser 
                165                 170                 175     


Asn Thr Gln Asp Pro Gln Ser Tyr His Cys Ser Cys Pro Arg Ala Phe 
            180                 185                 190         


Thr Gly Lys Asp Cys Gly Thr Glu Lys Cys Phe Asp Glu Thr Arg Tyr 
        195                 200                 205             


Glu Tyr Leu Glu Gly Gly Asp Arg Trp Ala Arg Val Arg Gln Gly His 
    210                 215                 220                 


Val Glu Gln Cys Glu Cys Phe Gly Gly Arg Thr Trp Cys Glu Gly Thr 
225                 230                 235                 240 


Arg His Thr Ala Cys Leu Ser Ser Pro Cys Leu Asn Gly Gly Thr Cys 
                245                 250                 255     


His Leu Ile Val Ala Thr Gly Thr Thr Val Cys Ala Cys Pro Pro Gly 
            260                 265                 270         


Phe Ala Gly Arg Leu Cys Asn Ile Glu Pro Asp Glu Arg Cys Phe Leu 
        275                 280                 285             


Gly Asn Gly Thr Gly Tyr Arg Gly Val Ala Ser Thr Ser Ala Ser Gly 
    290                 295                 300                 


Leu Ser Cys Leu Ala Trp Asn Ser Asp Leu Leu Tyr Gln Glu Leu His 
305                 310                 315                 320 


Val Asp Ser Val Gly Ala Ala Ala Leu Leu Gly Leu Gly Pro His Ala 
                325                 330                 335     


Tyr Cys Arg Asn Pro Asp Asn Asp Glu Arg Pro Trp Cys Tyr Val Val 
            340                 345                 350         


Lys Asp Ser Ala Leu Ser Trp Glu Tyr Cys Arg Leu Glu Ala Cys Glu 
        355                 360                 365             


Ser Leu Thr Arg Val Gln Leu Ser Pro Asp Leu Leu Ala Thr Leu Pro 
    370                 375                 380                 


Glu Pro Ala Ser Pro Gly Arg Gln Ala Cys Gly Arg Arg His Lys Lys 
385                 390                 395                 400 


Arg Thr Phe Leu Arg Pro Arg Ile Ile Gly Gly Ser Ser Ser Leu Pro 
                405                 410                 415     


Gly Ser His Pro Trp Leu Ala Ala Ile Tyr Ile Gly Asp Ser Phe Cys 
            420                 425                 430         


Ala Gly Ser Leu Val His Thr Cys Trp Val Val Ser Ala Ala His Cys 
        435                 440                 445             


Phe Ser His Ser Pro Pro Arg Asp Ser Val Ser Val Val Leu Gly Gln 
    450                 455                 460                 


His Phe Phe Asn Arg Thr Thr Asp Val Thr Gln Thr Phe Gly Ile Glu 
465                 470                 475                 480 


Lys Tyr Ile Pro Tyr Thr Leu Tyr Ser Val Phe Asn Pro Ser Asp His 
                485                 490                 495     


Asp Leu Val Leu Ile Arg Leu Lys Lys Lys Gly Asp Arg Cys Ala Thr 
            500                 505                 510         


Arg Ser Gln Phe Val Gln Pro Ile Cys Leu Pro Glu Pro Gly Ser Thr 
        515                 520                 525             


Phe Pro Ala Gly His Lys Cys Gln Ile Ala Gly Trp Gly His Leu Asp 
    530                 535                 540                 


Glu Asn Val Ser Gly Tyr Ser Ser Ser Leu Arg Glu Ala Leu Val Pro 
545                 550                 555                 560 


Leu Val Ala Asp His Lys Cys Ser Ser Pro Glu Val Tyr Gly Ala Asp 
                565                 570                 575     


Ile Ser Pro Asn Met Leu Cys Ala Gly Tyr Phe Asp Cys Lys Ser Asp 
            580                 585                 590         


Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Ala Cys Glu Lys Asn Gly 
        595                 600                 605             


Val Ala Tyr Leu Tyr Gly Ile Ile Ser Trp Gly Asp Gly Cys Gly Arg 
    610                 615                 620                 


Leu His Lys Pro Gly Val Tyr Thr Arg Val Ala Asn Tyr Val Asp Trp 
625                 630                 635                 640 


Ile Asn Asp Arg Ile Arg Pro Pro Arg Arg Leu Val Ala Pro Ser 
                645                 650                 655 


<210>  69
<211>  1408
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (204)..(1277)

<400>  69
ataaaacaga catctcttgt tttccagata ctacgggtca taatccctaa ctccaatcac       60

tggcaactcc tgagatcaga ggaaaaccag caacagcgtg ggagtttggg gagaggcatt      120

ccataccaga ttctgtggcc tgcaggtgac atgctgccta agagaagcag gagtctgtga      180

cagccacccc aacacgtgac gtc atg gcc agt agg gaa gat gag ctg agg aac      233
                          Met Ala Ser Arg Glu Asp Glu Leu Arg Asn         
                          1               5                   10          

tgt gtg gta tgt ggg gac caa gcc aca ggc tac cac ttt aat gcg ctg        281
Cys Val Val Cys Gly Asp Gln Ala Thr Gly Tyr His Phe Asn Ala Leu           
                15                  20                  25                

act tgt gag ggc tgc aag ggt ttc ttc agg aga aca gtc agc aaa agc        329
Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Thr Val Ser Lys Ser           
            30                  35                  40                    

att ggt ccc acc tgc ccc ttt gct gga agc tgt gaa gtc agc aag act        377
Ile Gly Pro Thr Cys Pro Phe Ala Gly Ser Cys Glu Val Ser Lys Thr           
        45                  50                  55                        

cag agg cgc cac tgc cca gcc tgc agg ttg cag aag tgc tta gat gct        425
Gln Arg Arg His Cys Pro Ala Cys Arg Leu Gln Lys Cys Leu Asp Ala           
    60                  65                  70                            

ggc atg agg aaa gac atg ata ctg tcg gca gaa gcc ctg gca ttg cgg        473
Gly Met Arg Lys Asp Met Ile Leu Ser Ala Glu Ala Leu Ala Leu Arg           
75                  80                  85                  90            

cga gca aag cag gcc cag cgg cgg gca cag caa aca cct gtg caa ctg        521
Arg Ala Lys Gln Ala Gln Arg Arg Ala Gln Gln Thr Pro Val Gln Leu           
                95                  100                 105               

agt aag gag caa gaa gag ctg atc cgg aca ctc ctg ggg gcc cac acc        569
Ser Lys Glu Gln Glu Glu Leu Ile Arg Thr Leu Leu Gly Ala His Thr           
            110                 115                 120                   

cgc cac atg ggc acc atg ttt gaa cag ttt gtg cag ttt agg cct cca        617
Arg His Met Gly Thr Met Phe Glu Gln Phe Val Gln Phe Arg Pro Pro           
        125                 130                 135                       

gct cat ctg ttc atc cat cac cag ccc ttg ccc acc ctg gcc cct gtg        665
Ala His Leu Phe Ile His His Gln Pro Leu Pro Thr Leu Ala Pro Val           
    140                 145                 150                           

ctg cct ctg gtc aca cac ttc gca gac atc aac act ttc atg gta ctg        713
Leu Pro Leu Val Thr His Phe Ala Asp Ile Asn Thr Phe Met Val Leu           
155                 160                 165                 170           

caa gtc atc aag ttt act aag gac ctg ccc gtc ttc cgt tcc ctg ccc        761
Gln Val Ile Lys Phe Thr Lys Asp Leu Pro Val Phe Arg Ser Leu Pro           
                175                 180                 185               

att gaa gac cag atc tcc ctt ctc aag gga gca gct gtg gaa atc tgt        809
Ile Glu Asp Gln Ile Ser Leu Leu Lys Gly Ala Ala Val Glu Ile Cys           
            190                 195                 200                   

cac atc gta ctc aat acc act ttc tgt ctc caa aca caa aac ttc ctc        857
His Ile Val Leu Asn Thr Thr Phe Cys Leu Gln Thr Gln Asn Phe Leu           
        205                 210                 215                       

tgc ggg cct ctt cgc tac aca att gaa gat gga gcc cgt gta tct ccc        905
Cys Gly Pro Leu Arg Tyr Thr Ile Glu Asp Gly Ala Arg Val Ser Pro           
    220                 225                 230                           

aca gtg ggg ttc cag gta gag ttt ttg gag ttg ctc ttt cac ttc cat        953
Thr Val Gly Phe Gln Val Glu Phe Leu Glu Leu Leu Phe His Phe His           
235                 240                 245                 250           

gga aca cta cga aaa ctg cag ctc caa gag cct gag tat gtg ctc ttg       1001
Gly Thr Leu Arg Lys Leu Gln Leu Gln Glu Pro Glu Tyr Val Leu Leu           
                255                 260                 265               

gct gcc atg gcc ctc ttc tct cct gct ccc tat ctt aca gac cga cct       1049
Ala Ala Met Ala Leu Phe Ser Pro Ala Pro Tyr Leu Thr Asp Arg Pro           
            270                 275                 280                   

gga gtt acc cag aga gat gag att gat cag ctg caa gag gag atg gca       1097
Gly Val Thr Gln Arg Asp Glu Ile Asp Gln Leu Gln Glu Glu Met Ala           
        285                 290                 295                       

ctg act ctg caa agc tac atc aag ggc cag cag cga agg ccc cgg gat       1145
Leu Thr Leu Gln Ser Tyr Ile Lys Gly Gln Gln Arg Arg Pro Arg Asp           
    300                 305                 310                           

cgg ttt ctg tat gcg aag ttg cta ggc ctg ctg gct gag ctc cgg agc       1193
Arg Phe Leu Tyr Ala Lys Leu Leu Gly Leu Leu Ala Glu Leu Arg Ser           
315                 320                 325                 330           

att aat gag gcc tac ggg tac caa atc cag cac atc cag ggc ctg tct       1241
Ile Asn Glu Ala Tyr Gly Tyr Gln Ile Gln His Ile Gln Gly Leu Ser           
                335                 340                 345               

gcc atg atg ccg ctg ctc cag gag atc tgc agc tga ggccatgctc            1287
Ala Met Met Pro Leu Leu Gln Glu Ile Cys Ser                               
            350                 355                                       

acttccttcc ccagctcacc tggaacaccc tggatacact ggagtgggaa aatgctggga     1347

ccaaagattg ggccgggttc aaagggagcc cagtggttgc aatgaaagac taaagcaata     1407

a                                                                     1408


<210>  70
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Ser Arg Glu Asp Glu Leu Arg Asn Cys Val Val Cys Gly Asp 
1               5                   10                  15      


Gln Ala Thr Gly Tyr His Phe Asn Ala Leu Thr Cys Glu Gly Cys Lys 
            20                  25                  30          


Gly Phe Phe Arg Arg Thr Val Ser Lys Ser Ile Gly Pro Thr Cys Pro 
        35                  40                  45              


Phe Ala Gly Ser Cys Glu Val Ser Lys Thr Gln Arg Arg His Cys Pro 
    50                  55                  60                  


Ala Cys Arg Leu Gln Lys Cys Leu Asp Ala Gly Met Arg Lys Asp Met 
65                  70                  75                  80  


Ile Leu Ser Ala Glu Ala Leu Ala Leu Arg Arg Ala Lys Gln Ala Gln 
                85                  90                  95      


Arg Arg Ala Gln Gln Thr Pro Val Gln Leu Ser Lys Glu Gln Glu Glu 
            100                 105                 110         


Leu Ile Arg Thr Leu Leu Gly Ala His Thr Arg His Met Gly Thr Met 
        115                 120                 125             


Phe Glu Gln Phe Val Gln Phe Arg Pro Pro Ala His Leu Phe Ile His 
    130                 135                 140                 


His Gln Pro Leu Pro Thr Leu Ala Pro Val Leu Pro Leu Val Thr His 
145                 150                 155                 160 


Phe Ala Asp Ile Asn Thr Phe Met Val Leu Gln Val Ile Lys Phe Thr 
                165                 170                 175     


Lys Asp Leu Pro Val Phe Arg Ser Leu Pro Ile Glu Asp Gln Ile Ser 
            180                 185                 190         


Leu Leu Lys Gly Ala Ala Val Glu Ile Cys His Ile Val Leu Asn Thr 
        195                 200                 205             


Thr Phe Cys Leu Gln Thr Gln Asn Phe Leu Cys Gly Pro Leu Arg Tyr 
    210                 215                 220                 


Thr Ile Glu Asp Gly Ala Arg Val Ser Pro Thr Val Gly Phe Gln Val 
225                 230                 235                 240 


Glu Phe Leu Glu Leu Leu Phe His Phe His Gly Thr Leu Arg Lys Leu 
                245                 250                 255     


Gln Leu Gln Glu Pro Glu Tyr Val Leu Leu Ala Ala Met Ala Leu Phe 
            260                 265                 270         


Ser Pro Ala Pro Tyr Leu Thr Asp Arg Pro Gly Val Thr Gln Arg Asp 
        275                 280                 285             


Glu Ile Asp Gln Leu Gln Glu Glu Met Ala Leu Thr Leu Gln Ser Tyr 
    290                 295                 300                 


Ile Lys Gly Gln Gln Arg Arg Pro Arg Asp Arg Phe Leu Tyr Ala Lys 
305                 310                 315                 320 


Leu Leu Gly Leu Leu Ala Glu Leu Arg Ser Ile Asn Glu Ala Tyr Gly 
                325                 330                 335     


Tyr Gln Ile Gln His Ile Gln Gly Leu Ser Ala Met Met Pro Leu Leu 
            340                 345                 350         


Gln Glu Ile Cys Ser 
        355         


<210>  71
<211>  454
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (57)..(329)

<400>  71
ggagtccaaa tcactcattg tttgtgaaag ctgagctcac agcaaaacaa gccacc atg       59
                                                              Met         
                                                              1           

aag ctg tcg gtg tgt ctc ctg ctg gtc acg ctg gcc ctc tgc tgc tac        107
Lys Leu Ser Val Cys Leu Leu Leu Val Thr Leu Ala Leu Cys Cys Tyr           
            5                   10                  15                    

cag gcc aat gcc gag ttc tgc cca gct ctt gtt tct gag ctg tta gac        155
Gln Ala Asn Ala Glu Phe Cys Pro Ala Leu Val Ser Glu Leu Leu Asp           
        20                  25                  30                        

ttc ttc ttc att agt gaa cct ctg ttc aag tta agt ctt gcc aaa ttt        203
Phe Phe Phe Ile Ser Glu Pro Leu Phe Lys Leu Ser Leu Ala Lys Phe           
    35                  40                  45                            

gat gcc cct ccg gaa gct gtt gca gcc aag tta gga gtg aag aga tgc        251
Asp Ala Pro Pro Glu Ala Val Ala Ala Lys Leu Gly Val Lys Arg Cys           
50                  55                  60                  65            

acg gat cag atg tcc ctt cag aaa cga agc ctc att gcg gaa gtc ctg        299
Thr Asp Gln Met Ser Leu Gln Lys Arg Ser Leu Ile Ala Glu Val Leu           
                70                  75                  80                

gtg aaa ata ttg aag aaa tgt agt gtg tga catgtaaaaa ctttcatcct          349
Val Lys Ile Leu Lys Lys Cys Ser Val                                       
            85                  90                                        

ggtttccact gtctttcaat gacaccctga tcttcactgc agaatgtaaa ggtttcaacg      409

tcttgcttta ataaatcact tgctctccaa aaaaaaaaaa aaaaa                      454


<210>  72
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Lys Leu Ser Val Cys Leu Leu Leu Val Thr Leu Ala Leu Cys Cys 
1               5                   10                  15      


Tyr Gln Ala Asn Ala Glu Phe Cys Pro Ala Leu Val Ser Glu Leu Leu 
            20                  25                  30          


Asp Phe Phe Phe Ile Ser Glu Pro Leu Phe Lys Leu Ser Leu Ala Lys 
        35                  40                  45              


Phe Asp Ala Pro Pro Glu Ala Val Ala Ala Lys Leu Gly Val Lys Arg 
    50                  55                  60                  


Cys Thr Asp Gln Met Ser Leu Gln Lys Arg Ser Leu Ile Ala Glu Val 
65                  70                  75                  80  


Leu Val Lys Ile Leu Lys Lys Cys Ser Val 
                85                  90  


<210>  73
<211>  1394
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (495)..(1196)

<400>  73
ttaaggaggt gcagtcttat gggagggaca ggggcggagt cagtctttaa aagctgttcc       60

caggtctggc ccgcctgcca caaacgctga gcccaggtgg gagaggtctg gcctatccgc      120

gcctggcagc tgtcggaact ccggagacca caaaggggtt tatggtttac cccctccacg      180

gaaggtcggt ctgatcgcag ctgcgggtcg gggagaggga ccgggggtcc cccagtcagt      240

aggcctcaga acacctcttc agtgccgggg caccagacag cggattttgc attcgactct      300

ccccaaagtg tgccgaacag gttggaagca aaggctccgg tttaagctct gggcttgggg      360

ataaaataca ctttttaagg acccaagttc ctcggcaacg actccagact gggaagacct      420

ttccattttc aggatcgacg cttcacgttg aggggagggc attcaggacg ccctcttaag      480

gcttctccca accc atg gcg cta cca ggc tcc tca cag gac cag gcc tgg        530
                Met Ala Leu Pro Gly Ser Ser Gln Asp Gln Ala Trp           
                1               5                   10                    

agc ctg gag cct ccg gct gcc acg gct gct gcc tcc tca tct tcg gga        578
Ser Leu Glu Pro Pro Ala Ala Thr Ala Ala Ala Ser Ser Ser Ser Gly           
        15                  20                  25                        

ccc cag gag cgg gag ggc gct ggg agc ccc gcg gcc ccc ggg acg ctg        626
Pro Gln Glu Arg Glu Gly Ala Gly Ser Pro Ala Ala Pro Gly Thr Leu           
    30                  35                  40                            

ccc ctg gag aag gtg aag cgg ccg atg aac gcg ttc atg gtg tgg agc        674
Pro Leu Glu Lys Val Lys Arg Pro Met Asn Ala Phe Met Val Trp Ser           
45                  50                  55                  60            

tcc gct cag cgc cgc cag atg gcg cag cag aac ccc aag atg cac aac        722
Ser Ala Gln Arg Arg Gln Met Ala Gln Gln Asn Pro Lys Met His Asn           
                65                  70                  75                

tcc gag atc tcc aag cgc ctg ggc gcg cag tgg aag ctg ctg gac gag        770
Ser Glu Ile Ser Lys Arg Leu Gly Ala Gln Trp Lys Leu Leu Asp Glu           
            80                  85                  90                    

gac gag aag cgg ccc ttc gtg gag gag gcc aag cgg ctc cgc gcc cga        818
Asp Glu Lys Arg Pro Phe Val Glu Glu Ala Lys Arg Leu Arg Ala Arg           
        95                  100                 105                       

cac ctg cgc gac tac ccc gac tac aag tac cgg cct cgg cgc aag gcc        866
His Leu Arg Asp Tyr Pro Asp Tyr Lys Tyr Arg Pro Arg Arg Lys Ala           
    110                 115                 120                           

aag agc tcg ggc gcc gga cct tcc cgc tgc gga cag gga aga ggc aac        914
Lys Ser Ser Gly Ala Gly Pro Ser Arg Cys Gly Gln Gly Arg Gly Asn           
125                 130                 135                 140           

ctg gcc agc ggc ggc ccg ctc tgg ggg ccg ggg tac gcg acc acc caa        962
Leu Ala Ser Gly Gly Pro Leu Trp Gly Pro Gly Tyr Ala Thr Thr Gln           
                145                 150                 155               

ccg agc aga ggc ttt ggg tac aga ccc ccc agc tac tcg aca gcc tac       1010
Pro Ser Arg Gly Phe Gly Tyr Arg Pro Pro Ser Tyr Ser Thr Ala Tyr           
            160                 165                 170                   

ctg cct ggc agc tat ggc tct tcc cac tgc aaa ctg gaa gcc ccc tca       1058
Leu Pro Gly Ser Tyr Gly Ser Ser His Cys Lys Leu Glu Ala Pro Ser           
        175                 180                 185                       

ccg tgc tcc ctc cct cag agt gac cct agg ctc cag ggg gaa ctg ctg       1106
Pro Cys Ser Leu Pro Gln Ser Asp Pro Arg Leu Gln Gly Glu Leu Leu           
    190                 195                 200                           

ccc acc tat acc cac tac ctg ccc cct ggc tct ccc act cca tac aac       1154
Pro Thr Tyr Thr His Tyr Leu Pro Pro Gly Ser Pro Thr Pro Tyr Asn           
205                 210                 215                 220           

cct ccc ctt gct ggt gcc ccc atg ccc cta acc cac ctc taa               1196
Pro Pro Leu Ala Gly Ala Pro Met Pro Leu Thr His Leu                       
                225                 230                                   

ccctcatgga cgcagacctc acgggacggg cctcatcctc cttttttaat ccagcagcat     1256

cccctacccc aggctgtcaa ccctttctcc tgttggacta cagttcagag gcagcctgca     1316

gtcctcccat gatagccagg gagagccgca caacatacaa ttatattttt ggtagtatta     1376

aacagttttg tattattc                                                   1394


<210>  74
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Leu Pro Gly Ser Ser Gln Asp Gln Ala Trp Ser Leu Glu Pro 
1               5                   10                  15      


Pro Ala Ala Thr Ala Ala Ala Ser Ser Ser Ser Gly Pro Gln Glu Arg 
            20                  25                  30          


Glu Gly Ala Gly Ser Pro Ala Ala Pro Gly Thr Leu Pro Leu Glu Lys 
        35                  40                  45              


Val Lys Arg Pro Met Asn Ala Phe Met Val Trp Ser Ser Ala Gln Arg 
    50                  55                  60                  


Arg Gln Met Ala Gln Gln Asn Pro Lys Met His Asn Ser Glu Ile Ser 
65                  70                  75                  80  


Lys Arg Leu Gly Ala Gln Trp Lys Leu Leu Asp Glu Asp Glu Lys Arg 
                85                  90                  95      


Pro Phe Val Glu Glu Ala Lys Arg Leu Arg Ala Arg His Leu Arg Asp 
            100                 105                 110         


Tyr Pro Asp Tyr Lys Tyr Arg Pro Arg Arg Lys Ala Lys Ser Ser Gly 
        115                 120                 125             


Ala Gly Pro Ser Arg Cys Gly Gln Gly Arg Gly Asn Leu Ala Ser Gly 
    130                 135                 140                 


Gly Pro Leu Trp Gly Pro Gly Tyr Ala Thr Thr Gln Pro Ser Arg Gly 
145                 150                 155                 160 


Phe Gly Tyr Arg Pro Pro Ser Tyr Ser Thr Ala Tyr Leu Pro Gly Ser 
                165                 170                 175     


Tyr Gly Ser Ser His Cys Lys Leu Glu Ala Pro Ser Pro Cys Ser Leu 
            180                 185                 190         


Pro Gln Ser Asp Pro Arg Leu Gln Gly Glu Leu Leu Pro Thr Tyr Thr 
        195                 200                 205             


His Tyr Leu Pro Pro Gly Ser Pro Thr Pro Tyr Asn Pro Pro Leu Ala 
    210                 215                 220                 


Gly Ala Pro Met Pro Leu Thr His Leu 
225                 230             


<210>  75
<211>  1309
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (135)..(1172)

<400>  75
agaaaagcaa gggcagggtt cagaaagact gaatgtaaag ctgggctctg agtctgccag       60

gcccttcgtg tgttgctctg cacattaatt aaagggtcta cgaggtcagc aaggacgccc      120

aagaagactc agtc atg aaa ggt gaa ctg ctc ctg ttt tcc agt gtg att        170
                Met Lys Gly Glu Leu Leu Leu Phe Ser Ser Val Ile           
                1               5                   10                    

gtc ctg ctc cag gtg gta tgc agc tgc ccg gac aag tgt tac tgt cag        218
Val Leu Leu Gln Val Val Cys Ser Cys Pro Asp Lys Cys Tyr Cys Gln           
        15                  20                  25                        

tca tct aca aat ttt gta gac tgc agc cag cag ggt ctg gcc gaa atc        266
Ser Ser Thr Asn Phe Val Asp Cys Ser Gln Gln Gly Leu Ala Glu Ile           
    30                  35                  40                            

cct tcc cat tta cct cct cag act cga acg ctg cat tta caa gat aat        314
Pro Ser His Leu Pro Pro Gln Thr Arg Thr Leu His Leu Gln Asp Asn           
45                  50                  55                  60            

cag ata cac cat ctt cct gct ttt gca ttt agg tca gtg cca tgg ctc        362
Gln Ile His His Leu Pro Ala Phe Ala Phe Arg Ser Val Pro Trp Leu           
                65                  70                  75                

atg acc tta aac ttg tcc aac aat tcc ctt tca aat ctg gcc cct gga        410
Met Thr Leu Asn Leu Ser Asn Asn Ser Leu Ser Asn Leu Ala Pro Gly           
            80                  85                  90                    

gct ttc cat ggg ctt cag cac ttg cag gtt tta aat cta acc cag aat        458
Ala Phe His Gly Leu Gln His Leu Gln Val Leu Asn Leu Thr Gln Asn           
        95                  100                 105                       

tca ctc ctt tcc ctg gaa agc aga ctt ttc cat tcc ctc cct cag ctg        506
Ser Leu Leu Ser Leu Glu Ser Arg Leu Phe His Ser Leu Pro Gln Leu           
    110                 115                 120                           

agg gag ctt gat ttg tca tca aac aac ata agc cac ctt ccc aca tcc        554
Arg Glu Leu Asp Leu Ser Ser Asn Asn Ile Ser His Leu Pro Thr Ser           
125                 130                 135                 140           

ttg gga gag act tgg gag aac cta act ata ctt gcg gtt caa caa aac        602
Leu Gly Glu Thr Trp Glu Asn Leu Thr Ile Leu Ala Val Gln Gln Asn           
                145                 150                 155               

cag ctt cag cag ctt gat cga gcg ctc ctg gaa tcc atg ccc agt gtg        650
Gln Leu Gln Gln Leu Asp Arg Ala Leu Leu Glu Ser Met Pro Ser Val           
            160                 165                 170                   

agg ctt tta ctt ctc aag gac aac ctc tgg aaa tgc aat tgc cac ttg        698
Arg Leu Leu Leu Leu Lys Asp Asn Leu Trp Lys Cys Asn Cys His Leu           
        175                 180                 185                       

ctc ggt ctt aaa ctc tgg ctg gag aaa ttt gtc tat aaa ggg gga cta        746
Leu Gly Leu Lys Leu Trp Leu Glu Lys Phe Val Tyr Lys Gly Gly Leu           
    190                 195                 200                           

aca gac ggc atc atc tgt gaa tca cca gac acc tgg aag gga aag gac        794
Thr Asp Gly Ile Ile Cys Glu Ser Pro Asp Thr Trp Lys Gly Lys Asp           
205                 210                 215                 220           

ctc ctt agg atc cct cat gag ctg tac cag ccc tgc cct ctt cct gct        842
Leu Leu Arg Ile Pro His Glu Leu Tyr Gln Pro Cys Pro Leu Pro Ala           
                225                 230                 235               

cct gat cca gtg tcc tcg cag gct cag tgg ccc ggc tct gcc cac ggt        890
Pro Asp Pro Val Ser Ser Gln Ala Gln Trp Pro Gly Ser Ala His Gly           
            240                 245                 250                   

gtg gtc ctg agg cct cct gag aac cac aac gcg ggg gag cga gaa ctc        938
Val Val Leu Arg Pro Pro Glu Asn His Asn Ala Gly Glu Arg Glu Leu           
        255                 260                 265                       

ttg gag tgc gag ctc aaa ccc aag cca agg ccg gcc aac ctg cgt cat        986
Leu Glu Cys Glu Leu Lys Pro Lys Pro Arg Pro Ala Asn Leu Arg His           
    270                 275                 280                           

gcc att gcc act gtc atc atc act ggc gtt gtg tgt ggg att gtg tgt       1034
Ala Ile Ala Thr Val Ile Ile Thr Gly Val Val Cys Gly Ile Val Cys           
285                 290                 295                 300           

ctc atg atg ttg gca gct gcc atc tat ggc tgc acc tat gcg gca atc       1082
Leu Met Met Leu Ala Ala Ala Ile Tyr Gly Cys Thr Tyr Ala Ala Ile           
                305                 310                 315               

aca gcc cag tac cat ggg gga ccc ttg gct caa acc aat gat cct ggg       1130
Thr Ala Gln Tyr His Gly Gly Pro Leu Ala Gln Thr Asn Asp Pro Gly           
            320                 325                 330                   

aag gtg gaa gaa aaa gag cga ttt gac agc tca cca gcc tga               1172
Lys Val Glu Glu Lys Glu Arg Phe Asp Ser Ser Pro Ala                       
        335                 340                 345                       

gagcttttgt ctcaaatagg attggtcatt gcaggccaga agatagtgtc tgagtagggc     1232

tgatgtgttt cctgttagtc tgattttgct tttgccaaaa gacaaaaaaa aaaaaaaaaa     1292

aaaaaaaaaa aaaaaaa                                                    1309


<210>  76
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Lys Gly Glu Leu Leu Leu Phe Ser Ser Val Ile Val Leu Leu Gln 
1               5                   10                  15      


Val Val Cys Ser Cys Pro Asp Lys Cys Tyr Cys Gln Ser Ser Thr Asn 
            20                  25                  30          


Phe Val Asp Cys Ser Gln Gln Gly Leu Ala Glu Ile Pro Ser His Leu 
        35                  40                  45              


Pro Pro Gln Thr Arg Thr Leu His Leu Gln Asp Asn Gln Ile His His 
    50                  55                  60                  


Leu Pro Ala Phe Ala Phe Arg Ser Val Pro Trp Leu Met Thr Leu Asn 
65                  70                  75                  80  


Leu Ser Asn Asn Ser Leu Ser Asn Leu Ala Pro Gly Ala Phe His Gly 
                85                  90                  95      


Leu Gln His Leu Gln Val Leu Asn Leu Thr Gln Asn Ser Leu Leu Ser 
            100                 105                 110         


Leu Glu Ser Arg Leu Phe His Ser Leu Pro Gln Leu Arg Glu Leu Asp 
        115                 120                 125             


Leu Ser Ser Asn Asn Ile Ser His Leu Pro Thr Ser Leu Gly Glu Thr 
    130                 135                 140                 


Trp Glu Asn Leu Thr Ile Leu Ala Val Gln Gln Asn Gln Leu Gln Gln 
145                 150                 155                 160 


Leu Asp Arg Ala Leu Leu Glu Ser Met Pro Ser Val Arg Leu Leu Leu 
                165                 170                 175     


Leu Lys Asp Asn Leu Trp Lys Cys Asn Cys His Leu Leu Gly Leu Lys 
            180                 185                 190         


Leu Trp Leu Glu Lys Phe Val Tyr Lys Gly Gly Leu Thr Asp Gly Ile 
        195                 200                 205             


Ile Cys Glu Ser Pro Asp Thr Trp Lys Gly Lys Asp Leu Leu Arg Ile 
    210                 215                 220                 


Pro His Glu Leu Tyr Gln Pro Cys Pro Leu Pro Ala Pro Asp Pro Val 
225                 230                 235                 240 


Ser Ser Gln Ala Gln Trp Pro Gly Ser Ala His Gly Val Val Leu Arg 
                245                 250                 255     


Pro Pro Glu Asn His Asn Ala Gly Glu Arg Glu Leu Leu Glu Cys Glu 
            260                 265                 270         


Leu Lys Pro Lys Pro Arg Pro Ala Asn Leu Arg His Ala Ile Ala Thr 
        275                 280                 285             


Val Ile Ile Thr Gly Val Val Cys Gly Ile Val Cys Leu Met Met Leu 
    290                 295                 300                 


Ala Ala Ala Ile Tyr Gly Cys Thr Tyr Ala Ala Ile Thr Ala Gln Tyr 
305                 310                 315                 320 


His Gly Gly Pro Leu Ala Gln Thr Asn Asp Pro Gly Lys Val Glu Glu 
                325                 330                 335     


Lys Glu Arg Phe Asp Ser Ser Pro Ala 
            340                 345 


<210>  77
<211>  3209
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (181)..(1164)

<400>  77
gtcagctgcc agagggcggg gccgcaggag ggcggggcgc gagcgagagc tgggagaagg       60

cagtgagcga gcaggcggca ggcacggtcc gtgcggagca ggcgagcgag cgggaagacg      120

cagccacctt cctcaccagc cagcccacag cggtttgttc cccttctcgg gagtgcgcca      180

atg cct ggg ccg acc caa acc ctg tcc cca aat ggc gag aac aac aac        228
Met Pro Gly Pro Thr Gln Thr Leu Ser Pro Asn Gly Glu Asn Asn Asn           
1               5                   10                  15                

gac atc atc cag gat aat aac ggg acc atc att cct ttc cgg aag cac        276
Asp Ile Ile Gln Asp Asn Asn Gly Thr Ile Ile Pro Phe Arg Lys His           
            20                  25                  30                    

aca gtg cgc ggg gag cgt tcc tac agt tgg gga atg gcg gtc aat gtg        324
Thr Val Arg Gly Glu Arg Ser Tyr Ser Trp Gly Met Ala Val Asn Val           
        35                  40                  45                        

tat tct acc tcg ata acc caa gag act atg agc aga cat gac atc att        372
Tyr Ser Thr Ser Ile Thr Gln Glu Thr Met Ser Arg His Asp Ile Ile           
    50                  55                  60                            

gca tgg gtt aat gac ata gta tct tta aac tac aca aaa gtg gaa cag        420
Ala Trp Val Asn Asp Ile Val Ser Leu Asn Tyr Thr Lys Val Glu Gln           
65                  70                  75                  80            

ctt tgt tca gga gcg gcc tat tgc caa ttc atg gac atg ctc ttc cct        468
Leu Cys Ser Gly Ala Ala Tyr Cys Gln Phe Met Asp Met Leu Phe Pro           
                85                  90                  95                

ggc tgc att agt ttg aag aaa gta aaa ttt caa gca aag ctg gaa cat        516
Gly Cys Ile Ser Leu Lys Lys Val Lys Phe Gln Ala Lys Leu Glu His           
            100                 105                 110                   

gaa tat att cac aat ttt aaa ctt ctg caa gca tca ttt aag cga atg        564
Glu Tyr Ile His Asn Phe Lys Leu Leu Gln Ala Ser Phe Lys Arg Met           
        115                 120                 125                       

aac gtt gat aag gta att cca gtg gag aag cta gtg aaa gga cgt ttc        612
Asn Val Asp Lys Val Ile Pro Val Glu Lys Leu Val Lys Gly Arg Phe           
    130                 135                 140                           

cag gac aac ctg gat ttt att caa tgg ttt aag aaa ttc tat gat gct        660
Gln Asp Asn Leu Asp Phe Ile Gln Trp Phe Lys Lys Phe Tyr Asp Ala           
145                 150                 155                 160           

aac tac gat ggg aag gag tat gat cct gta gag gca cga caa ggg caa        708
Asn Tyr Asp Gly Lys Glu Tyr Asp Pro Val Glu Ala Arg Gln Gly Gln           
                165                 170                 175               

gat gca att cct cct cct gac cct ggt gaa cag atc ttc aac ctg cca        756
Asp Ala Ile Pro Pro Pro Asp Pro Gly Glu Gln Ile Phe Asn Leu Pro           
            180                 185                 190                   

aaa aag tct cac cat gca aac tcc ccc aca gca ggt gca gct aaa tca        804
Lys Lys Ser His His Ala Asn Ser Pro Thr Ala Gly Ala Ala Lys Ser           
        195                 200                 205                       

agt cca gca gct aaa cca gga tcc aca cct tct cga ccc tca tca gcc        852
Ser Pro Ala Ala Lys Pro Gly Ser Thr Pro Ser Arg Pro Ser Ser Ala           
    210                 215                 220                           

aaa agg gct tct tcc agt ggc tca gca tcc aaa tcc gat aaa gat tta        900
Lys Arg Ala Ser Ser Ser Gly Ser Ala Ser Lys Ser Asp Lys Asp Leu           
225                 230                 235                 240           

gaa acg cag gtc ata cag ctt aat gaa cag gta cat tca tta aaa ctt        948
Glu Thr Gln Val Ile Gln Leu Asn Glu Gln Val His Ser Leu Lys Leu           
                245                 250                 255               

gcc ctt gaa ggc gtg gaa aag gaa agg gat ttc tac ttt ggg aag ttg        996
Ala Leu Glu Gly Val Glu Lys Glu Arg Asp Phe Tyr Phe Gly Lys Leu           
            260                 265                 270                   

aga gag atc gag cta ctc tgc caa gaa cac ggg cag gaa aat gat gac       1044
Arg Glu Ile Glu Leu Leu Cys Gln Glu His Gly Gln Glu Asn Asp Asp           
        275                 280                 285                       

ctc gtg cag aga cta atg gac atc ctg tat gct tca gaa gaa cac gag       1092
Leu Val Gln Arg Leu Met Asp Ile Leu Tyr Ala Ser Glu Glu His Glu           
    290                 295                 300                           

ggc cac aca gaa gag ccg gaa gca gag gag caa gcc cac gaa cag cag       1140
Gly His Thr Glu Glu Pro Glu Ala Glu Glu Gln Ala His Glu Gln Gln           
305                 310                 315                 320           

ccc ccg cag cag gaa gag tac tga cccaccccgg ctgctcttga cacttccatt      1194
Pro Pro Gln Gln Glu Glu Tyr                                               
                325                                                       

gtgtgtggga acgtttcttc tggagaattg gaacatgtgt ggccccaagc tcaacagaaa     1254

ccagttgttc ccaatctgcc gttaccatca acgcactgtt gcatatgcca gccactgcgc     1314

ttggttccca ttttctttgc caaggtgtat tagcggacgg ccctctggcc acctacccga     1374

gagatcgtag ggtcacatac atccaacttc accacttggc tgcttgagat tggttctgct     1434

cttttcttca tttctttcca gaacaactct ttcccacccc aacaccactg ccaccacccc     1494

tctttttatc ctggtgtgaa acaatggtaa tttgatatat ggtatttata ttggcatttt     1554

tcaacccagt gtcactagat gtcacacaca tttgtggtgc tttgatgttt gcaagtctaa     1614

cctctgaaca taaatttggt caaataattg gaacaaaggg aaacagatac ttgatatgaa     1674

agccataatg acggtgactt gtgtcgtggg ggaaaacata aggtcatttt ctccctctac     1734

tcacaatact aaagggaaaa aatggattca aagctaggat ttcagggccc agcagtgttc     1794

ctccatcagc atgttagaca actacacagt atgttgttag ttttgaaaga cattcactca     1854

aggaaaacac catctcaact ttgcccgctc accatgtccc ttgcccccat gtagcccatt     1914

tcccaggtta tgctcttttc tttctcaggg tcctctttgg tgggcagcca ctccccgaga     1974

tgttgccatc agttttctgc agtccaaaga gggtatggtt aggtacgggt cttcctgcct     2034

cattcctctt cctctttgtg taggtttcag ccacaaaact gtcattcact ctaggggacc     2094

cctactaaag ggtaacttca ggtgtgcagc cctgagctcc aaggctctgc accatgccac     2154

acacttgctg taaggctaga agtgaagacc ttattaatag gagcataatt gcgagggaga     2214

atcatggttc tgcagtctgg tgtagacact ggaataacag cacagaaaaa tctatgactc     2274

ccaatatctt ctagaataaa gaattttccc tctttaacac aagggccctc cttgtcattg     2334

accttagcta aaccatggca attcataaat agaggaaaca ttaatgaatt aaaagcattc     2394

cttatttttt aactaatatt tgtacatttt cttagtctct ttccaagtct ttgcctcttt     2454

tttttcttta tttttatttt ttcctttgac agatggtatc ccttcctgga tcattcattt     2514

caccttggtt tctaacttta ggtttacttt cacttgttat ttgacttagc aggtgcaaca     2574

aaaacaagaa acaaatgtgc ccaccccact ttccgcttaa ctgaaaagct taaaataaat     2634

ttctgaatta tgtatcctga agctttgaaa tttctttatt aatcgatgaa atatgaattc     2694

taaattctag cattgaagct tttcaccaaa agaagtctct ccaaaataaa tcttttgcag     2754

caaagtgata tttattgagt tatgtggaaa agatggcttg tatttttcag attattacaa     2814

cacactgtgc agaattagac agatgttccg tggtgtttgg tttccctttc ttctctctcc     2874

tgctcactct gcattatagc agcagcttat ttctctaagg ctggacagcc tggctctcgg     2934

cagtgacgtc ctcccacacc tggtcacaag tagtagtggc tgtgctatac ccagcatcat     2994

gcttaacagc gtgttgccct tctgagcctg ttgtactcac tgatctcttt aaaaacaaaa     3054

aatagctctt gtaaaaggtc acaataactc tatgcacctg atactgcagt ggttcctagg     3114

ccattcttca tctgctctgg acatctcagt catacccaat gctcagtgga tcatgaccaa     3174

actcctgtca tgtggatgca cgtgagtggg tagca                                3209


<210>  78
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Pro Gly Pro Thr Gln Thr Leu Ser Pro Asn Gly Glu Asn Asn Asn 
1               5                   10                  15      


Asp Ile Ile Gln Asp Asn Asn Gly Thr Ile Ile Pro Phe Arg Lys His 
            20                  25                  30          


Thr Val Arg Gly Glu Arg Ser Tyr Ser Trp Gly Met Ala Val Asn Val 
        35                  40                  45              


Tyr Ser Thr Ser Ile Thr Gln Glu Thr Met Ser Arg His Asp Ile Ile 
    50                  55                  60                  


Ala Trp Val Asn Asp Ile Val Ser Leu Asn Tyr Thr Lys Val Glu Gln 
65                  70                  75                  80  


Leu Cys Ser Gly Ala Ala Tyr Cys Gln Phe Met Asp Met Leu Phe Pro 
                85                  90                  95      


Gly Cys Ile Ser Leu Lys Lys Val Lys Phe Gln Ala Lys Leu Glu His 
            100                 105                 110         


Glu Tyr Ile His Asn Phe Lys Leu Leu Gln Ala Ser Phe Lys Arg Met 
        115                 120                 125             


Asn Val Asp Lys Val Ile Pro Val Glu Lys Leu Val Lys Gly Arg Phe 
    130                 135                 140                 


Gln Asp Asn Leu Asp Phe Ile Gln Trp Phe Lys Lys Phe Tyr Asp Ala 
145                 150                 155                 160 


Asn Tyr Asp Gly Lys Glu Tyr Asp Pro Val Glu Ala Arg Gln Gly Gln 
                165                 170                 175     


Asp Ala Ile Pro Pro Pro Asp Pro Gly Glu Gln Ile Phe Asn Leu Pro 
            180                 185                 190         


Lys Lys Ser His His Ala Asn Ser Pro Thr Ala Gly Ala Ala Lys Ser 
        195                 200                 205             


Ser Pro Ala Ala Lys Pro Gly Ser Thr Pro Ser Arg Pro Ser Ser Ala 
    210                 215                 220                 


Lys Arg Ala Ser Ser Ser Gly Ser Ala Ser Lys Ser Asp Lys Asp Leu 
225                 230                 235                 240 


Glu Thr Gln Val Ile Gln Leu Asn Glu Gln Val His Ser Leu Lys Leu 
                245                 250                 255     


Ala Leu Glu Gly Val Glu Lys Glu Arg Asp Phe Tyr Phe Gly Lys Leu 
            260                 265                 270         


Arg Glu Ile Glu Leu Leu Cys Gln Glu His Gly Gln Glu Asn Asp Asp 
        275                 280                 285             


Leu Val Gln Arg Leu Met Asp Ile Leu Tyr Ala Ser Glu Glu His Glu 
    290                 295                 300                 


Gly His Thr Glu Glu Pro Glu Ala Glu Glu Gln Ala His Glu Gln Gln 
305                 310                 315                 320 


Pro Pro Gln Gln Glu Glu Tyr 
                325         


<210>  79
<211>  1221
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (149)..(625)

<400>  79
gggtcctcgg agctgctctg gctgcgcgcg gagcgggctc cggagggaag tcccgagaca       60

aagggaagcg ccgccgccgc cgccccgctc ggtcctccac ctgtccgcta cgctcgccgg      120

ggctgcggcc gcccgaggga ctttgaac atg tcg ggg atc gcc ctc agc aga         172
                               Met Ser Gly Ile Ala Leu Ser Arg            
                               1               5                          

ctc gcc cag gag agg aaa gca tgg agg aaa gac cac cca ttt ggt ttc        220
Leu Ala Gln Glu Arg Lys Ala Trp Arg Lys Asp His Pro Phe Gly Phe           
    10                  15                  20                            

gtg gct gtc cca aca aaa aat ccc gat ggc acg atg aac ctc atg aac        268
Val Ala Val Pro Thr Lys Asn Pro Asp Gly Thr Met Asn Leu Met Asn           
25                  30                  35                  40            

tgg gag tgc gcc att cca gga aag aaa ggg act ccg tgg gaa gga ggc        316
Trp Glu Cys Ala Ile Pro Gly Lys Lys Gly Thr Pro Trp Glu Gly Gly           
                45                  50                  55                

ttg ttt aaa cta cgg atg ctt ttc aaa gat gat tat cca tct tcg cca        364
Leu Phe Lys Leu Arg Met Leu Phe Lys Asp Asp Tyr Pro Ser Ser Pro           
            60                  65                  70                    

cca aaa tgt aaa ttc gaa cca cca tta ttt cac ccg aat gtg tac cct        412
Pro Lys Cys Lys Phe Glu Pro Pro Leu Phe His Pro Asn Val Tyr Pro           
        75                  80                  85                        

tcg ggg aca gtg tgc ctg tcc atc tta gag gag gac aag gac tgg agg        460
Ser Gly Thr Val Cys Leu Ser Ile Leu Glu Glu Asp Lys Asp Trp Arg           
    90                  95                  100                           

cca gcc atc aca atc aaa cag atc cta tta gga ata cag gaa ctt cta        508
Pro Ala Ile Thr Ile Lys Gln Ile Leu Leu Gly Ile Gln Glu Leu Leu           
105                 110                 115                 120           

aat gaa cca aat atc caa gac cca gct caa gca gag gcc tac acg att        556
Asn Glu Pro Asn Ile Gln Asp Pro Ala Gln Ala Glu Ala Tyr Thr Ile           
                125                 130                 135               

tac tgc caa aac aga gtg gag tac gag aaa agg gtc cga gca caa gcc        604
Tyr Cys Gln Asn Arg Val Glu Tyr Glu Lys Arg Val Arg Ala Gln Ala           
            140                 145                 150                   

aag aag ttt gcg ccc tca taa gcagcgacct tgtggcatcg tcaaaaggaa           655
Lys Lys Phe Ala Pro Ser                                                   
        155                                                               

gggattggtt tggcaagaac ttgtttacaa catttttgca aatctaaagt tgctccatac      715

aatgactagt cacctggggg ggttgggcgg gcgccatctt ccattgccgc cgcgggtgtg      775

cggtctcgat tcgctgaatt gcccgtttcc atacagggtc tcttccttcg gtcttttgta      835

tttttgattg ttatgtaaaa ctcgctttta ttttaatatt gatgtcagta tttcaactgc      895

tgtaaaatta taaactttta tacttgggta agtcccccag gggcgagttc ctcgctctgg      955

gatgcaggca tgcttctcac cgtgcagagc tgcacttggc ctcagctggc tgtatggaaa     1015

tgcaccctcc ctcctgccgc tcctctctag aaccttctag aacctgggct gtgctgcttt     1075

tgagcctcag accccaggtc agcatctcgg ttctgcgcca cttcctttgt gtttatatgg     1135

cgttttgtct gtgttgctgt ttagagtaaa taaactgttt atataaaggt tttggttgca     1195

ttattatcat tgaaagtgag aggagg                                          1221


<210>  80
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ser Gly Ile Ala Leu Ser Arg Leu Ala Gln Glu Arg Lys Ala Trp 
1               5                   10                  15      


Arg Lys Asp His Pro Phe Gly Phe Val Ala Val Pro Thr Lys Asn Pro 
            20                  25                  30          


Asp Gly Thr Met Asn Leu Met Asn Trp Glu Cys Ala Ile Pro Gly Lys 
        35                  40                  45              


Lys Gly Thr Pro Trp Glu Gly Gly Leu Phe Lys Leu Arg Met Leu Phe 
    50                  55                  60                  


Lys Asp Asp Tyr Pro Ser Ser Pro Pro Lys Cys Lys Phe Glu Pro Pro 
65                  70                  75                  80  


Leu Phe His Pro Asn Val Tyr Pro Ser Gly Thr Val Cys Leu Ser Ile 
                85                  90                  95      


Leu Glu Glu Asp Lys Asp Trp Arg Pro Ala Ile Thr Ile Lys Gln Ile 
            100                 105                 110         


Leu Leu Gly Ile Gln Glu Leu Leu Asn Glu Pro Asn Ile Gln Asp Pro 
        115                 120                 125             


Ala Gln Ala Glu Ala Tyr Thr Ile Tyr Cys Gln Asn Arg Val Glu Tyr 
    130                 135                 140                 


Glu Lys Arg Val Arg Ala Gln Ala Lys Lys Phe Ala Pro Ser 
145                 150                 155             


<210>  81
<211>  4661
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (159)..(3971)

<400>  81
tttttgaatc tgcggaggcg gcggcggtgg cagcggcggc gcggcgactg aagcgcgcga       60

aaagctgagg cggcaacgtc ggggacggct gcgcgggacg gctctgtagg aaggaacttg      120

gttccccctc cctcagcttc cgccccaaaa gattcaga atg gac agt tta gaa gaa      176
                                          Met Asp Ser Leu Glu Glu         
                                          1               5               

cct cag aaa aaa gtc ttt aag gct cga aaa acg atg aga gtg agt gat        224
Pro Gln Lys Lys Val Phe Lys Ala Arg Lys Thr Met Arg Val Ser Asp           
            10                  15                  20                    

cgt cag caa ctt gaa gca gtg tac aag gtc aaa gaa gaa ctg ttg aaa        272
Arg Gln Gln Leu Glu Ala Val Tyr Lys Val Lys Glu Glu Leu Leu Lys           
        25                  30                  35                        

act gat gtc aag ctg tta aat ggc aac cat gaa aat gga gat ttg gac        320
Thr Asp Val Lys Leu Leu Asn Gly Asn His Glu Asn Gly Asp Leu Asp           
    40                  45                  50                            

cca acc tca cct ttg gaa aac atg gat tac att aaa gac aag gaa gag        368
Pro Thr Ser Pro Leu Glu Asn Met Asp Tyr Ile Lys Asp Lys Glu Glu           
55                  60                  65                  70            

gtg aat ggc att gaa gag att tgt ttt gat cct gaa gga agt aaa gca        416
Val Asn Gly Ile Glu Glu Ile Cys Phe Asp Pro Glu Gly Ser Lys Ala           
                75                  80                  85                

gaa tgg aag gaa aca ccc tgt atc cta agt gtt aat gta aaa aac aag        464
Glu Trp Lys Glu Thr Pro Cys Ile Leu Ser Val Asn Val Lys Asn Lys           
            90                  95                  100                   

cag gat gat gat tta aat tgt gaa cct ttg tct ccc cat aat ata act        512
Gln Asp Asp Asp Leu Asn Cys Glu Pro Leu Ser Pro His Asn Ile Thr           
        105                 110                 115                       

cca gaa cca gtc tct aaa ctg cct gct gaa cca gtt tct ggt gat cca        560
Pro Glu Pro Val Ser Lys Leu Pro Ala Glu Pro Val Ser Gly Asp Pro           
    120                 125                 130                           

gcc cct ggt gat ctg gat gcc gga gat cca gcc tcc gga gta ctg gcc        608
Ala Pro Gly Asp Leu Asp Ala Gly Asp Pro Ala Ser Gly Val Leu Ala           
135                 140                 145                 150           

tct ggt gat tcc acc tct ggt gat ccc acc tct agc gag ccc tcc tct        656
Ser Gly Asp Ser Thr Ser Gly Asp Pro Thr Ser Ser Glu Pro Ser Ser           
                155                 160                 165               

agt gat gct gcc tct ggt gat gca acc tct ggt gat gcc cct tct ggt        704
Ser Asp Ala Ala Ser Gly Asp Ala Thr Ser Gly Asp Ala Pro Ser Gly           
            170                 175                 180                   

gat gtg tcc cct ggt gat gcc acc tct ggt gat gcc act gct gat gat        752
Asp Val Ser Pro Gly Asp Ala Thr Ser Gly Asp Ala Thr Ala Asp Asp           
        185                 190                 195                       

ctc tcc tct ggt gat ccc acc tct agt gat ccc atc cca ggt gaa ccg        800
Leu Ser Ser Gly Asp Pro Thr Ser Ser Asp Pro Ile Pro Gly Glu Pro           
    200                 205                 210                           

gtc cct gtt gaa ccc att tct ggt gat tgt gcc gct gat gat ata gcc        848
Val Pro Val Glu Pro Ile Ser Gly Asp Cys Ala Ala Asp Asp Ile Ala           
215                 220                 225                 230           

tct agt gaa ata act tct gtt gat ctg gct tct gga gca cca gct tcc        896
Ser Ser Glu Ile Thr Ser Val Asp Leu Ala Ser Gly Ala Pro Ala Ser           
                235                 240                 245               

act gat cca gcc tct gat gat ctg gcc tct ggt gat cta tcc tct agt        944
Thr Asp Pro Ala Ser Asp Asp Leu Ala Ser Gly Asp Leu Ser Ser Ser           
            250                 255                 260                   

gaa ctg gcc tct gat gat ctg gcc act ggt gaa ctg gcc tct gat gag        992
Glu Leu Ala Ser Asp Asp Leu Ala Thr Gly Glu Leu Ala Ser Asp Glu           
        265                 270                 275                       

ctg act tct gaa tca acc ttt gat cgt acc ttt gaa cca aag tct gta       1040
Leu Thr Ser Glu Ser Thr Phe Asp Arg Thr Phe Glu Pro Lys Ser Val           
    280                 285                 290                           

cca gtt tgt gaa cca gtt cct gaa att gac aat ata gaa cca agt agc       1088
Pro Val Cys Glu Pro Val Pro Glu Ile Asp Asn Ile Glu Pro Ser Ser           
295                 300                 305                 310           

aat aaa gat gat gat ttt ctt gaa aaa aat gga gct gat gaa aaa tta       1136
Asn Lys Asp Asp Asp Phe Leu Glu Lys Asn Gly Ala Asp Glu Lys Leu           
                315                 320                 325               

gag caa att cag agt aaa gac tca ttg gat gag aaa aat aaa gct gat       1184
Glu Gln Ile Gln Ser Lys Asp Ser Leu Asp Glu Lys Asn Lys Ala Asp           
            330                 335                 340                   

aat aat att gat gct aat gaa gaa act cta gaa aca gat gat aca act       1232
Asn Asn Ile Asp Ala Asn Glu Glu Thr Leu Glu Thr Asp Asp Thr Thr           
        345                 350                 355                       

att tgt tca gat cga cct cct gaa aat gaa aag aag gta gag gaa gat       1280
Ile Cys Ser Asp Arg Pro Pro Glu Asn Glu Lys Lys Val Glu Glu Asp           
    360                 365                 370                           

att atc aca gag ctt gct ctt gga gaa gat gct ata tct agc agt atg       1328
Ile Ile Thr Glu Leu Ala Leu Gly Glu Asp Ala Ile Ser Ser Ser Met           
375                 380                 385                 390           

gaa att gac caa ggt gaa aag aat gaa gat gaa act tct gca gat ctt       1376
Glu Ile Asp Gln Gly Glu Lys Asn Glu Asp Glu Thr Ser Ala Asp Leu           
                395                 400                 405               

gta gaa acg att aat gaa aat gtt att gaa gat aac aaa agt gag aat       1424
Val Glu Thr Ile Asn Glu Asn Val Ile Glu Asp Asn Lys Ser Glu Asn           
            410                 415                 420                   

atc tta gaa aat aca gac tct atg gag aca gat gaa atc att cct att       1472
Ile Leu Glu Asn Thr Asp Ser Met Glu Thr Asp Glu Ile Ile Pro Ile           
        425                 430                 435                       

ttg gaa aag ctt gca cct tct gag gat gaa ctt act tgc ttt tct aaa       1520
Leu Glu Lys Leu Ala Pro Ser Glu Asp Glu Leu Thr Cys Phe Ser Lys           
    440                 445                 450                           

aca tct ctc ctt cca atc gat gag aca aat cca gat ttg gaa gag aaa       1568
Thr Ser Leu Leu Pro Ile Asp Glu Thr Asn Pro Asp Leu Glu Glu Lys           
455                 460                 465                 470           

atg gaa agt tct ttt ggt tca cca tct aaa caa gaa agt agt gag agt       1616
Met Glu Ser Ser Phe Gly Ser Pro Ser Lys Gln Glu Ser Ser Glu Ser           
                475                 480                 485               

ttg cca aaa gaa gcc ttt ctg gtc ctc tct gat gaa gag gat att tcg       1664
Leu Pro Lys Glu Ala Phe Leu Val Leu Ser Asp Glu Glu Asp Ile Ser           
            490                 495                 500                   

ggt gaa aaa gat gag tct gaa gtt ata tcg caa aat gaa acg tgc tct       1712
Gly Glu Lys Asp Glu Ser Glu Val Ile Ser Gln Asn Glu Thr Cys Ser           
        505                 510                 515                       

cca gca gaa gta gaa agt aat gaa aag gac aac aaa cct gag gaa gaa       1760
Pro Ala Glu Val Glu Ser Asn Glu Lys Asp Asn Lys Pro Glu Glu Glu           
    520                 525                 530                           

gag caa gta ata cat gaa gat gat gaa aga cct tct gag aaa aat gaa       1808
Glu Gln Val Ile His Glu Asp Asp Glu Arg Pro Ser Glu Lys Asn Glu           
535                 540                 545                 550           

ttt tct aga cga aaa cgt tct aaa tca gaa gac atg gac aat gta cag       1856
Phe Ser Arg Arg Lys Arg Ser Lys Ser Glu Asp Met Asp Asn Val Gln           
                555                 560                 565               

tct aaa cgt cgt cga tat atg gaa gaa gaa tat gag gca gaa ttt caa       1904
Ser Lys Arg Arg Arg Tyr Met Glu Glu Glu Tyr Glu Ala Glu Phe Gln           
            570                 575                 580                   

gta aag att aca gcc aaa gga gac att aac cag aaa ctt caa aag gtt       1952
Val Lys Ile Thr Ala Lys Gly Asp Ile Asn Gln Lys Leu Gln Lys Val           
        585                 590                 595                       

ata cag tgg ttg ctg gaa gaa aaa ttg tgt gcg ctg cag tgt gct gta       2000
Ile Gln Trp Leu Leu Glu Glu Lys Leu Cys Ala Leu Gln Cys Ala Val           
    600                 605                 610                           

ttt gat aag act ttg gca gaa ttg aaa aca cga gtg gaa aag att gaa       2048
Phe Asp Lys Thr Leu Ala Glu Leu Lys Thr Arg Val Glu Lys Ile Glu           
615                 620                 625                 630           

tgt aac aag agg cat aaa aca gtt ctc act gaa cta cag gcc aag ata       2096
Cys Asn Lys Arg His Lys Thr Val Leu Thr Glu Leu Gln Ala Lys Ile           
                635                 640                 645               

gcc agg tta acc aaa cgc ttt gaa gca gcc aaa gaa gat ctt aag aaa       2144
Ala Arg Leu Thr Lys Arg Phe Glu Ala Ala Lys Glu Asp Leu Lys Lys           
            650                 655                 660                   

aga cat gaa cat cca ccc aac cca cca gta tca cca gga aaa act gta       2192
Arg His Glu His Pro Pro Asn Pro Pro Val Ser Pro Gly Lys Thr Val           
        665                 670                 675                       

aat gat gtc aac agc aat aat aac atg tct tac aga aat gca ggc aca       2240
Asn Asp Val Asn Ser Asn Asn Asn Met Ser Tyr Arg Asn Ala Gly Thr           
    680                 685                 690                           

gtg aga cag atg ctg gag tcc aaa aga aat gta agc gag agt gca cca       2288
Val Arg Gln Met Leu Glu Ser Lys Arg Asn Val Ser Glu Ser Ala Pro           
695                 700                 705                 710           

cca tcc ttt caa act cct gtg aat aca gta tct tca acc aat ctt gtc       2336
Pro Ser Phe Gln Thr Pro Val Asn Thr Val Ser Ser Thr Asn Leu Val           
                715                 720                 725               

act cct cca gca gtt gtc agt agt caa cct aaa ttg cag act cca gtg       2384
Thr Pro Pro Ala Val Val Ser Ser Gln Pro Lys Leu Gln Thr Pro Val           
            730                 735                 740                   

act tcg ggt tcc ctc aca gca acg tca gtt ctt cct gca ccc aat aca       2432
Thr Ser Gly Ser Leu Thr Ala Thr Ser Val Leu Pro Ala Pro Asn Thr           
        745                 750                 755                       

gct act gta gtt gct act act cag gtg cct agt gga aat ccc cag cct       2480
Ala Thr Val Val Ala Thr Thr Gln Val Pro Ser Gly Asn Pro Gln Pro           
    760                 765                 770                           

aca atc tct tta cag cct ttg cca gtg att ttg cat gta cct gtt gca       2528
Thr Ile Ser Leu Gln Pro Leu Pro Val Ile Leu His Val Pro Val Ala           
775                 780                 785                 790           

gta tcc tcc cag cct cag ctt cta cag agc cat cca ggg act ttg gtg       2576
Val Ser Ser Gln Pro Gln Leu Leu Gln Ser His Pro Gly Thr Leu Val           
                795                 800                 805               

act aat caa cca tct ggc aat gtt gaa ttc att tct gtg caa agc cca       2624
Thr Asn Gln Pro Ser Gly Asn Val Glu Phe Ile Ser Val Gln Ser Pro           
            810                 815                 820                   

cct aca gtg agt ggt ctt acc aaa aat cca gta tcc ttg cca tcc ttg       2672
Pro Thr Val Ser Gly Leu Thr Lys Asn Pro Val Ser Leu Pro Ser Leu           
        825                 830                 835                       

cca aat ccc act aaa cca aac aac gtt cct tct gtg ccc agt cct agt       2720
Pro Asn Pro Thr Lys Pro Asn Asn Val Pro Ser Val Pro Ser Pro Ser           
    840                 845                 850                           

att caa agg aac cct act gcc agt gct gca cca ttg gga aca aca ctt       2768
Ile Gln Arg Asn Pro Thr Ala Ser Ala Ala Pro Leu Gly Thr Thr Leu           
855                 860                 865                 870           

gct gtg cag gct gtt cca aca gca cac tct att gta caa gcc aca agg       2816
Ala Val Gln Ala Val Pro Thr Ala His Ser Ile Val Gln Ala Thr Arg           
                875                 880                 885               

act tct tta ccc aca gtg ggc cca tca gga ctc tat agt cca tca act       2864
Thr Ser Leu Pro Thr Val Gly Pro Ser Gly Leu Tyr Ser Pro Ser Thr           
            890                 895                 900                   

aat cga ggt cct ata cag atg aaa att cca att tct gca ttt agt act       2912
Asn Arg Gly Pro Ile Gln Met Lys Ile Pro Ile Ser Ala Phe Ser Thr           
        905                 910                 915                       

tcg tct gct gca gaa cag aac agc aat acc acc cca aga att gaa aac       2960
Ser Ser Ala Ala Glu Gln Asn Ser Asn Thr Thr Pro Arg Ile Glu Asn           
    920                 925                 930                           

cag aca aac aaa aca ata gat gct tct gtc agt aag aaa gca gct gat       3008
Gln Thr Asn Lys Thr Ile Asp Ala Ser Val Ser Lys Lys Ala Ala Asp           
935                 940                 945                 950           

agc aca tca cag tgt gga aaa gcc act ggc agt gat tca agt ggt gtc       3056
Ser Thr Ser Gln Cys Gly Lys Ala Thr Gly Ser Asp Ser Ser Gly Val           
                955                 960                 965               

att gat ctc aca atg gat gat gaa gag agt gga gct tca caa gac ccc       3104
Ile Asp Leu Thr Met Asp Asp Glu Glu Ser Gly Ala Ser Gln Asp Pro           
            970                 975                 980                   

aaa aaa cta aat cac act cct gta tca acc atg agt tct tct cag cct       3152
Lys Lys Leu Asn His Thr Pro Val Ser Thr Met Ser Ser Ser Gln Pro           
        985                 990                 995                       

gtg tca  cga cca ttg caa ccc  ata caa cca gca ccg  cct ctt caa        3197
Val Ser  Arg Pro Leu Gln Pro  Ile Gln Pro Ala Pro  Pro Leu Gln            
    1000                 1005                 1010                        

cca tct  ggg gtg cca aca agt  gga cca tct cag acc  acc ata cac        3242
Pro Ser  Gly Val Pro Thr Ser  Gly Pro Ser Gln Thr  Thr Ile His            
    1015                 1020                 1025                        

tta cta  cct aca gct cca act  acc gtg aat gta aca  cat cgt cca        3287
Leu Leu  Pro Thr Ala Pro Thr  Thr Val Asn Val Thr  His Arg Pro            
    1030                 1035                 1040                        

gta act  cag gtg acc aca aga  ctc cct gta cca aga  gct cct gca        3332
Val Thr  Gln Val Thr Thr Arg  Leu Pro Val Pro Arg  Ala Pro Ala            
    1045                 1050                 1055                        

aac cac  cag gtg gtt tat aca  act ctt cct gca cca  cca gct cag        3377
Asn His  Gln Val Val Tyr Thr  Thr Leu Pro Ala Pro  Pro Ala Gln            
    1060                 1065                 1070                        

gct ccc  ttg cga gga act gtt  atg cag gct cct gct  gtt cgg cag        3422
Ala Pro  Leu Arg Gly Thr Val  Met Gln Ala Pro Ala  Val Arg Gln            
    1075                 1080                 1085                        

gtc aat  ccc caa aat agt gtt  aca gtt cga gtg cct  caa aca acc        3467
Val Asn  Pro Gln Asn Ser Val  Thr Val Arg Val Pro  Gln Thr Thr            
    1090                 1095                 1100                        

aca tat  gtt gta aac aat gga  cta acc ctg gga tca  aca gga cct        3512
Thr Tyr  Val Val Asn Asn Gly  Leu Thr Leu Gly Ser  Thr Gly Pro            
    1105                 1110                 1115                        

cag ctc  aca gtg cat cac cga  cca cca caa gtg cat  act gag ccc        3557
Gln Leu  Thr Val His His Arg  Pro Pro Gln Val His  Thr Glu Pro            
    1120                 1125                 1130                        

cca cgc  ccc gtg cac cca gca  ccc tta cca gaa gct  cca caa cca        3602
Pro Arg  Pro Val His Pro Ala  Pro Leu Pro Glu Ala  Pro Gln Pro            
    1135                 1140                 1145                        

cag cgt  ctg ccc cca gaa gct  gcc agc aca tct ctg  cct cag aag        3647
Gln Arg  Leu Pro Pro Glu Ala  Ala Ser Thr Ser Leu  Pro Gln Lys            
    1150                 1155                 1160                        

cca cac  ttg aag tta gca cgc  gtt cag agt caa aat  ggc ata gta        3692
Pro His  Leu Lys Leu Ala Arg  Val Gln Ser Gln Asn  Gly Ile Val            
    1165                 1170                 1175                        

ctg tca  tgg agt gtc ctg gag  gtg gat cga agc tgt  gcc act gtt        3737
Leu Ser  Trp Ser Val Leu Glu  Val Asp Arg Ser Cys  Ala Thr Val            
    1180                 1185                 1190                        

gat agc  tac cat ctc tat gct  tac cat gag gaa ccc  agt gcc act        3782
Asp Ser  Tyr His Leu Tyr Ala  Tyr His Glu Glu Pro  Ser Ala Thr            
    1195                 1200                 1205                        

gtg ccc  tca caa tgg aaa aag  att ggg gaa gtc aag  gca ctt ccc        3827
Val Pro  Ser Gln Trp Lys Lys  Ile Gly Glu Val Lys  Ala Leu Pro            
    1210                 1215                 1220                        

ttg ccc  atg gca tgt act ctc  acc cag ttt gta tct  ggt agc aaa        3872
Leu Pro  Met Ala Cys Thr Leu  Thr Gln Phe Val Ser  Gly Ser Lys            
    1225                 1230                 1235                        

tac tac  ttt gca gta cga gcc  aag gat att tat gga  cgt ttt ggg        3917
Tyr Tyr  Phe Ala Val Arg Ala  Lys Asp Ile Tyr Gly  Arg Phe Gly            
    1240                 1245                 1250                        

cct ttc  tgt gat cct cag tca  aca gat gtg atc tct  tct acc cag        3962
Pro Phe  Cys Asp Pro Gln Ser  Thr Asp Val Ile Ser  Ser Thr Gln            
    1255                 1260                 1265                        

agc agt  taa accttggagc ctttatattt tcctctttta aaatttccac              4011
Ser Ser                                                                   
    1270                                                                  

cttttggtct tgtttttaat cttgtgcatg ataccccatg taaaatccac cttgtgcaag     4071

atttcttgga cagatgtgtg tatacactac atttgtttat aaccagaagc aaaataaact     4131

cagcccacaa agctagaatc ttttcctgga cagtttaggc tttggggttt ggaaatgtaa     4191

atgtgtacct tgctttagtt ttgaggctgg ggaatatgtg tgggtgttta tgtgtgtttt     4251

tccttatgta ggtgttattg cattggagtc tcccattttc attctcaaat ttacctctta     4311

aagtacgaag taagtagatc aaaggatttg agatgtgtaa ctggcatgat tctgcttttg     4371

aaggatctat agtatcattt tagttaagtg ggtcaaacag aatcaaaaca aaacccaaag     4431

aaataaataa aaaacaaaat ggctaaatag tttaaaatag gttaattcga acacaggaaa     4491

ggatctattt gttgtttctt ttgtctggtc tcctgagttg ttaattaggt gaaaaaagat     4551

ctgcaatggc cccctccctt tcctaatctg gcttttacat ttattttgtg ccttaaagat     4611

taactacaaa gataaacatg gccaaaaata aataaataaa tatggccata                4661


<210>  82
<211>  1270
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Asp Ser Leu Glu Glu Pro Gln Lys Lys Val Phe Lys Ala Arg Lys 
1               5                   10                  15      


Thr Met Arg Val Ser Asp Arg Gln Gln Leu Glu Ala Val Tyr Lys Val 
            20                  25                  30          


Lys Glu Glu Leu Leu Lys Thr Asp Val Lys Leu Leu Asn Gly Asn His 
        35                  40                  45              


Glu Asn Gly Asp Leu Asp Pro Thr Ser Pro Leu Glu Asn Met Asp Tyr 
    50                  55                  60                  


Ile Lys Asp Lys Glu Glu Val Asn Gly Ile Glu Glu Ile Cys Phe Asp 
65                  70                  75                  80  


Pro Glu Gly Ser Lys Ala Glu Trp Lys Glu Thr Pro Cys Ile Leu Ser 
                85                  90                  95      


Val Asn Val Lys Asn Lys Gln Asp Asp Asp Leu Asn Cys Glu Pro Leu 
            100                 105                 110         


Ser Pro His Asn Ile Thr Pro Glu Pro Val Ser Lys Leu Pro Ala Glu 
        115                 120                 125             


Pro Val Ser Gly Asp Pro Ala Pro Gly Asp Leu Asp Ala Gly Asp Pro 
    130                 135                 140                 


Ala Ser Gly Val Leu Ala Ser Gly Asp Ser Thr Ser Gly Asp Pro Thr 
145                 150                 155                 160 


Ser Ser Glu Pro Ser Ser Ser Asp Ala Ala Ser Gly Asp Ala Thr Ser 
                165                 170                 175     


Gly Asp Ala Pro Ser Gly Asp Val Ser Pro Gly Asp Ala Thr Ser Gly 
            180                 185                 190         


Asp Ala Thr Ala Asp Asp Leu Ser Ser Gly Asp Pro Thr Ser Ser Asp 
        195                 200                 205             


Pro Ile Pro Gly Glu Pro Val Pro Val Glu Pro Ile Ser Gly Asp Cys 
    210                 215                 220                 


Ala Ala Asp Asp Ile Ala Ser Ser Glu Ile Thr Ser Val Asp Leu Ala 
225                 230                 235                 240 


Ser Gly Ala Pro Ala Ser Thr Asp Pro Ala Ser Asp Asp Leu Ala Ser 
                245                 250                 255     


Gly Asp Leu Ser Ser Ser Glu Leu Ala Ser Asp Asp Leu Ala Thr Gly 
            260                 265                 270         


Glu Leu Ala Ser Asp Glu Leu Thr Ser Glu Ser Thr Phe Asp Arg Thr 
        275                 280                 285             


Phe Glu Pro Lys Ser Val Pro Val Cys Glu Pro Val Pro Glu Ile Asp 
    290                 295                 300                 


Asn Ile Glu Pro Ser Ser Asn Lys Asp Asp Asp Phe Leu Glu Lys Asn 
305                 310                 315                 320 


Gly Ala Asp Glu Lys Leu Glu Gln Ile Gln Ser Lys Asp Ser Leu Asp 
                325                 330                 335     


Glu Lys Asn Lys Ala Asp Asn Asn Ile Asp Ala Asn Glu Glu Thr Leu 
            340                 345                 350         


Glu Thr Asp Asp Thr Thr Ile Cys Ser Asp Arg Pro Pro Glu Asn Glu 
        355                 360                 365             


Lys Lys Val Glu Glu Asp Ile Ile Thr Glu Leu Ala Leu Gly Glu Asp 
    370                 375                 380                 


Ala Ile Ser Ser Ser Met Glu Ile Asp Gln Gly Glu Lys Asn Glu Asp 
385                 390                 395                 400 


Glu Thr Ser Ala Asp Leu Val Glu Thr Ile Asn Glu Asn Val Ile Glu 
                405                 410                 415     


Asp Asn Lys Ser Glu Asn Ile Leu Glu Asn Thr Asp Ser Met Glu Thr 
            420                 425                 430         


Asp Glu Ile Ile Pro Ile Leu Glu Lys Leu Ala Pro Ser Glu Asp Glu 
        435                 440                 445             


Leu Thr Cys Phe Ser Lys Thr Ser Leu Leu Pro Ile Asp Glu Thr Asn 
    450                 455                 460                 


Pro Asp Leu Glu Glu Lys Met Glu Ser Ser Phe Gly Ser Pro Ser Lys 
465                 470                 475                 480 


Gln Glu Ser Ser Glu Ser Leu Pro Lys Glu Ala Phe Leu Val Leu Ser 
                485                 490                 495     


Asp Glu Glu Asp Ile Ser Gly Glu Lys Asp Glu Ser Glu Val Ile Ser 
            500                 505                 510         


Gln Asn Glu Thr Cys Ser Pro Ala Glu Val Glu Ser Asn Glu Lys Asp 
        515                 520                 525             


Asn Lys Pro Glu Glu Glu Glu Gln Val Ile His Glu Asp Asp Glu Arg 
    530                 535                 540                 


Pro Ser Glu Lys Asn Glu Phe Ser Arg Arg Lys Arg Ser Lys Ser Glu 
545                 550                 555                 560 


Asp Met Asp Asn Val Gln Ser Lys Arg Arg Arg Tyr Met Glu Glu Glu 
                565                 570                 575     


Tyr Glu Ala Glu Phe Gln Val Lys Ile Thr Ala Lys Gly Asp Ile Asn 
            580                 585                 590         


Gln Lys Leu Gln Lys Val Ile Gln Trp Leu Leu Glu Glu Lys Leu Cys 
        595                 600                 605             


Ala Leu Gln Cys Ala Val Phe Asp Lys Thr Leu Ala Glu Leu Lys Thr 
    610                 615                 620                 


Arg Val Glu Lys Ile Glu Cys Asn Lys Arg His Lys Thr Val Leu Thr 
625                 630                 635                 640 


Glu Leu Gln Ala Lys Ile Ala Arg Leu Thr Lys Arg Phe Glu Ala Ala 
                645                 650                 655     


Lys Glu Asp Leu Lys Lys Arg His Glu His Pro Pro Asn Pro Pro Val 
            660                 665                 670         


Ser Pro Gly Lys Thr Val Asn Asp Val Asn Ser Asn Asn Asn Met Ser 
        675                 680                 685             


Tyr Arg Asn Ala Gly Thr Val Arg Gln Met Leu Glu Ser Lys Arg Asn 
    690                 695                 700                 


Val Ser Glu Ser Ala Pro Pro Ser Phe Gln Thr Pro Val Asn Thr Val 
705                 710                 715                 720 


Ser Ser Thr Asn Leu Val Thr Pro Pro Ala Val Val Ser Ser Gln Pro 
                725                 730                 735     


Lys Leu Gln Thr Pro Val Thr Ser Gly Ser Leu Thr Ala Thr Ser Val 
            740                 745                 750         


Leu Pro Ala Pro Asn Thr Ala Thr Val Val Ala Thr Thr Gln Val Pro 
        755                 760                 765             


Ser Gly Asn Pro Gln Pro Thr Ile Ser Leu Gln Pro Leu Pro Val Ile 
    770                 775                 780                 


Leu His Val Pro Val Ala Val Ser Ser Gln Pro Gln Leu Leu Gln Ser 
785                 790                 795                 800 


His Pro Gly Thr Leu Val Thr Asn Gln Pro Ser Gly Asn Val Glu Phe 
                805                 810                 815     


Ile Ser Val Gln Ser Pro Pro Thr Val Ser Gly Leu Thr Lys Asn Pro 
            820                 825                 830         


Val Ser Leu Pro Ser Leu Pro Asn Pro Thr Lys Pro Asn Asn Val Pro 
        835                 840                 845             


Ser Val Pro Ser Pro Ser Ile Gln Arg Asn Pro Thr Ala Ser Ala Ala 
    850                 855                 860                 


Pro Leu Gly Thr Thr Leu Ala Val Gln Ala Val Pro Thr Ala His Ser 
865                 870                 875                 880 


Ile Val Gln Ala Thr Arg Thr Ser Leu Pro Thr Val Gly Pro Ser Gly 
                885                 890                 895     


Leu Tyr Ser Pro Ser Thr Asn Arg Gly Pro Ile Gln Met Lys Ile Pro 
            900                 905                 910         


Ile Ser Ala Phe Ser Thr Ser Ser Ala Ala Glu Gln Asn Ser Asn Thr 
        915                 920                 925             


Thr Pro Arg Ile Glu Asn Gln Thr Asn Lys Thr Ile Asp Ala Ser Val 
    930                 935                 940                 


Ser Lys Lys Ala Ala Asp Ser Thr Ser Gln Cys Gly Lys Ala Thr Gly 
945                 950                 955                 960 


Ser Asp Ser Ser Gly Val Ile Asp Leu Thr Met Asp Asp Glu Glu Ser 
                965                 970                 975     


Gly Ala Ser Gln Asp Pro Lys Lys Leu Asn His Thr Pro Val Ser Thr 
            980                 985                 990         


Met Ser Ser Ser Gln Pro Val Ser  Arg Pro Leu Gln Pro  Ile Gln Pro 
        995                 1000                 1005             


Ala Pro  Pro Leu Gln Pro Ser  Gly Val Pro Thr Ser  Gly Pro Ser 
    1010                 1015                 1020             


Gln Thr  Thr Ile His Leu Leu  Pro Thr Ala Pro Thr  Thr Val Asn 
    1025                 1030                 1035             


Val Thr  His Arg Pro Val Thr  Gln Val Thr Thr Arg  Leu Pro Val 
    1040                 1045                 1050             


Pro Arg  Ala Pro Ala Asn His  Gln Val Val Tyr Thr  Thr Leu Pro 
    1055                 1060                 1065             


Ala Pro  Pro Ala Gln Ala Pro  Leu Arg Gly Thr Val  Met Gln Ala 
    1070                 1075                 1080             


Pro Ala  Val Arg Gln Val Asn  Pro Gln Asn Ser Val  Thr Val Arg 
    1085                 1090                 1095             


Val Pro  Gln Thr Thr Thr Tyr  Val Val Asn Asn Gly  Leu Thr Leu 
    1100                 1105                 1110             


Gly Ser  Thr Gly Pro Gln Leu  Thr Val His His Arg  Pro Pro Gln 
    1115                 1120                 1125             


Val His  Thr Glu Pro Pro Arg  Pro Val His Pro Ala  Pro Leu Pro 
    1130                 1135                 1140             


Glu Ala  Pro Gln Pro Gln Arg  Leu Pro Pro Glu Ala  Ala Ser Thr 
    1145                 1150                 1155             


Ser Leu  Pro Gln Lys Pro His  Leu Lys Leu Ala Arg  Val Gln Ser 
    1160                 1165                 1170             


Gln Asn  Gly Ile Val Leu Ser  Trp Ser Val Leu Glu  Val Asp Arg 
    1175                 1180                 1185             


Ser Cys  Ala Thr Val Asp Ser  Tyr His Leu Tyr Ala  Tyr His Glu 
    1190                 1195                 1200             


Glu Pro  Ser Ala Thr Val Pro  Ser Gln Trp Lys Lys  Ile Gly Glu 
    1205                 1210                 1215             


Val Lys  Ala Leu Pro Leu Pro  Met Ala Cys Thr Leu  Thr Gln Phe 
    1220                 1225                 1230             


Val Ser  Gly Ser Lys Tyr Tyr  Phe Ala Val Arg Ala  Lys Asp Ile 
    1235                 1240                 1245             


Tyr Gly  Arg Phe Gly Pro Phe  Cys Asp Pro Gln Ser  Thr Asp Val 
    1250                 1255                 1260             


Ile Ser  Ser Thr Gln Ser Ser  
    1265                 1270 


<210>  83
<211>  3215
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (178)..(2415)

<400>  83
gacaatatca ggtgagctgt ggaggtgggg tccttggaag ctggatgaca gcagctggca       60

aggggataag agagcagtga gcccctccct caaggaggtc tggctttatc catagacagg      120

gccctctgag gtggggctga ggtacaaagg gggattgagc agcccaggag aagagag         177

atg ggg gtt ccc ttc ttc tct tct ctc aga tgc atg gtg gac tta gga        225
Met Gly Val Pro Phe Phe Ser Ser Leu Arg Cys Met Val Asp Leu Gly           
1               5                   10                  15                

cct tgc tgg gct ggg ggt ctc act gca gag atg aag ctg ctt ctg gcc        273
Pro Cys Trp Ala Gly Gly Leu Thr Ala Glu Met Lys Leu Leu Leu Ala           
            20                  25                  30                    

cta gca ggg ctc ctg gcc att ctg gcc acg ccc cag ccc tct gaa ggt        321
Leu Ala Gly Leu Leu Ala Ile Leu Ala Thr Pro Gln Pro Ser Glu Gly           
        35                  40                  45                        

gct gct cca gct gtc ctg ggg gag gtg gac acc tcg ttg gtg ctg agc        369
Ala Ala Pro Ala Val Leu Gly Glu Val Asp Thr Ser Leu Val Leu Ser           
    50                  55                  60                            

tcc atg gag gag gcc aag cag ctg gtg gac aag gcc tac aag gag cgg        417
Ser Met Glu Glu Ala Lys Gln Leu Val Asp Lys Ala Tyr Lys Glu Arg           
65                  70                  75                  80            

cgg gaa agc atc aag cag cgg ctt cgc agc ggc tca gcc agc ccc atg        465
Arg Glu Ser Ile Lys Gln Arg Leu Arg Ser Gly Ser Ala Ser Pro Met           
                85                  90                  95                

gaa ctc cta tcc tac ttc aag cag ccg gtg gca gcc acc agg acg gcg        513
Glu Leu Leu Ser Tyr Phe Lys Gln Pro Val Ala Ala Thr Arg Thr Ala           
            100                 105                 110                   

gtg agg gcc gct gac tac ctg cac gtg gct cta gac ctg ctg gag agg        561
Val Arg Ala Ala Asp Tyr Leu His Val Ala Leu Asp Leu Leu Glu Arg           
        115                 120                 125                       

aag ctg cgg tcc ctg tgg cga agg cca ttc aat gtc act gat gtg ctg        609
Lys Leu Arg Ser Leu Trp Arg Arg Pro Phe Asn Val Thr Asp Val Leu           
    130                 135                 140                           

acg ccc gcc cag ctg aat gtg ttg tcc aag tca agc ggc tgc gcc tac        657
Thr Pro Ala Gln Leu Asn Val Leu Ser Lys Ser Ser Gly Cys Ala Tyr           
145                 150                 155                 160           

cag gac gtg ggg gtg act tgc ccg gag cag gac aaa tac cgc acc atc        705
Gln Asp Val Gly Val Thr Cys Pro Glu Gln Asp Lys Tyr Arg Thr Ile           
                165                 170                 175               

acc ggg atg tgc aac aac aga cgc agc ccc acg ctg ggg gcc tcc aac        753
Thr Gly Met Cys Asn Asn Arg Arg Ser Pro Thr Leu Gly Ala Ser Asn           
            180                 185                 190                   

cgt gcc ttt gtg cgc tgg ctg ccg gcg gag tat gag gac ggc ttc tct        801
Arg Ala Phe Val Arg Trp Leu Pro Ala Glu Tyr Glu Asp Gly Phe Ser           
        195                 200                 205                       

ctt ccc tac ggc tgg acg ccc ggg gtc aag cgc aac ggc ttc ccg gtg        849
Leu Pro Tyr Gly Trp Thr Pro Gly Val Lys Arg Asn Gly Phe Pro Val           
    210                 215                 220                           

gct ctg gct cgc gcg gtc tcc aac gag atc gtg cgc ttc ccc act gat        897
Ala Leu Ala Arg Ala Val Ser Asn Glu Ile Val Arg Phe Pro Thr Asp           
225                 230                 235                 240           

cag ctg act ccg gac cag gag cgc tca ctc atg ttc atg caa tgg ggc        945
Gln Leu Thr Pro Asp Gln Glu Arg Ser Leu Met Phe Met Gln Trp Gly           
                245                 250                 255               

cag ctg ttg gac cac gac ctc gac ttc acc cct gag ccg gcc gcc cgg        993
Gln Leu Leu Asp His Asp Leu Asp Phe Thr Pro Glu Pro Ala Ala Arg           
            260                 265                 270                   

gcc tcc ttc gtc act ggc gtc aac tgc gag acc agc tgc gtt cag cag       1041
Ala Ser Phe Val Thr Gly Val Asn Cys Glu Thr Ser Cys Val Gln Gln           
        275                 280                 285                       

ccg ccc tgc ttc ccg ctc aag atc ccg ccc aat gac ccc cgc atc aag       1089
Pro Pro Cys Phe Pro Leu Lys Ile Pro Pro Asn Asp Pro Arg Ile Lys           
    290                 295                 300                           

aac caa gcc gac tgc atc ccg ttc ttc cgc tcc tgc ccg gct tgc ccc       1137
Asn Gln Ala Asp Cys Ile Pro Phe Phe Arg Ser Cys Pro Ala Cys Pro           
305                 310                 315                 320           

ggg agc aac atc acc atc cgc aac cag atc aac gcg ctc act tcc ttc       1185
Gly Ser Asn Ile Thr Ile Arg Asn Gln Ile Asn Ala Leu Thr Ser Phe           
                325                 330                 335               

gtg gac gcc agc atg gtg tac ggc agc gag gag ccc ctg gcc agg aac       1233
Val Asp Ala Ser Met Val Tyr Gly Ser Glu Glu Pro Leu Ala Arg Asn           
            340                 345                 350                   

ctg cgc aac atg tcc aac cag ctg ggg ctg ctg gcc gtc aac cag cgc       1281
Leu Arg Asn Met Ser Asn Gln Leu Gly Leu Leu Ala Val Asn Gln Arg           
        355                 360                 365                       

ttc caa gac aac ggc cgg gcc ctg ctg ccc ttt gac aac ctg cac gat       1329
Phe Gln Asp Asn Gly Arg Ala Leu Leu Pro Phe Asp Asn Leu His Asp           
    370                 375                 380                           

gac ccc tgt ctc ctc acc aac cgc tca gcg cgc atc ccc tgc ttc ctg       1377
Asp Pro Cys Leu Leu Thr Asn Arg Ser Ala Arg Ile Pro Cys Phe Leu           
385                 390                 395                 400           

gca ggg gac acc cgt tcc agt gag atg ccc gag ctc acc tcc atg cac       1425
Ala Gly Asp Thr Arg Ser Ser Glu Met Pro Glu Leu Thr Ser Met His           
                405                 410                 415               

acc ctc tta ctt cgg gag cac aac cgg ctg gcc aca gag ctc aag agc       1473
Thr Leu Leu Leu Arg Glu His Asn Arg Leu Ala Thr Glu Leu Lys Ser           
            420                 425                 430                   

ctg aac cct agg tgg gat ggg gag agg ctc tac cag gaa gcc cgg aag       1521
Leu Asn Pro Arg Trp Asp Gly Glu Arg Leu Tyr Gln Glu Ala Arg Lys           
        435                 440                 445                       

atc gtg ggg gcc atg gtc cag atc atc act tac cgg gac tac ctg ccc       1569
Ile Val Gly Ala Met Val Gln Ile Ile Thr Tyr Arg Asp Tyr Leu Pro           
    450                 455                 460                           

ctg gtg ctg ggg cca acg gcc atg agg aag tac ctg ccc acg tac cgt       1617
Leu Val Leu Gly Pro Thr Ala Met Arg Lys Tyr Leu Pro Thr Tyr Arg           
465                 470                 475                 480           

tcc tac aat gac tca gtg gac cca cgc atc gcc aac gtc ttc acc aat       1665
Ser Tyr Asn Asp Ser Val Asp Pro Arg Ile Ala Asn Val Phe Thr Asn           
                485                 490                 495               

gcc ttc cgc tac ggc cac acc ctc atc caa ccc ttc atg ttc cgc ctg       1713
Ala Phe Arg Tyr Gly His Thr Leu Ile Gln Pro Phe Met Phe Arg Leu           
            500                 505                 510                   

gac aat cgg tac cag ccc atg gaa ccc aac ccc cgt gtc ccc ctc agc       1761
Asp Asn Arg Tyr Gln Pro Met Glu Pro Asn Pro Arg Val Pro Leu Ser           
        515                 520                 525                       

agg gtc ttt ttt gcc tcc tgg agg gtc gtg ctg gaa ggt ggc att gac       1809
Arg Val Phe Phe Ala Ser Trp Arg Val Val Leu Glu Gly Gly Ile Asp           
    530                 535                 540                           

ccc atc ctc cgg ggc ctc atg gcc acc cct gcc aag ctg aat cgt cag       1857
Pro Ile Leu Arg Gly Leu Met Ala Thr Pro Ala Lys Leu Asn Arg Gln           
545                 550                 555                 560           

aac caa att gca gtg gat gag atc cgg gag cga ttg ttt gag cag gtc       1905
Asn Gln Ile Ala Val Asp Glu Ile Arg Glu Arg Leu Phe Glu Gln Val           
                565                 570                 575               

atg agg att ggg ctg gac ctg cct gct ctg aac atg cag cgc agc agg       1953
Met Arg Ile Gly Leu Asp Leu Pro Ala Leu Asn Met Gln Arg Ser Arg           
            580                 585                 590                   

gac cac ggc ctc cca gga tac aat gcc tgg agg cgc ttc tgt ggg ctc       2001
Asp His Gly Leu Pro Gly Tyr Asn Ala Trp Arg Arg Phe Cys Gly Leu           
        595                 600                 605                       

ccg cag cct gaa act gtg ggc cag ctg ggc acg gtg ctg agg aac ctg       2049
Pro Gln Pro Glu Thr Val Gly Gln Leu Gly Thr Val Leu Arg Asn Leu           
    610                 615                 620                           

aaa ttg gcg agg aaa ctg atg gag cag tat ggc acg ccc aac aac atc       2097
Lys Leu Ala Arg Lys Leu Met Glu Gln Tyr Gly Thr Pro Asn Asn Ile           
625                 630                 635                 640           

gac atc tgg atg ggc ggc gtg tcc gag cct ctg aag cgc aaa ggc cgc       2145
Asp Ile Trp Met Gly Gly Val Ser Glu Pro Leu Lys Arg Lys Gly Arg           
                645                 650                 655               

gtg ggc cca ctc ctc gcc tgc atc atc ggt acc cag ttc agg aag ctc       2193
Val Gly Pro Leu Leu Ala Cys Ile Ile Gly Thr Gln Phe Arg Lys Leu           
            660                 665                 670                   

cgg gat ggt gat cgg ttt tgg tgg gag aac gag ggt gtg ttc agc atg       2241
Arg Asp Gly Asp Arg Phe Trp Trp Glu Asn Glu Gly Val Phe Ser Met           
        675                 680                 685                       

cag cag cga cag gcc ctg gcc cag atc tca ttg ccc cgg atc atc tgc       2289
Gln Gln Arg Gln Ala Leu Ala Gln Ile Ser Leu Pro Arg Ile Ile Cys           
    690                 695                 700                           

gac aac aca ggc atc acc acc gtg tct aag aac aac atc ttc atg tcc       2337
Asp Asn Thr Gly Ile Thr Thr Val Ser Lys Asn Asn Ile Phe Met Ser           
705                 710                 715                 720           

aac tca tat ccc cgg gac ttt gtc aac tgc agt aca ctt cct gca ttg       2385
Asn Ser Tyr Pro Arg Asp Phe Val Asn Cys Ser Thr Leu Pro Ala Leu           
                725                 730                 735               

aac ctg gct tcc tgg agg gaa gcc tcc tag aggccaggta agggggtgca         2435
Asn Leu Ala Ser Trp Arg Glu Ala Ser                                       
            740                 745                                       

gcagtgaggg gtatatctgg gctggccagt tggaaccacg gagatctcct tgccctagat     2495

gagcccagcc ctgttctggg tgcagctgag aaaatgagtg actagacgtt catttgtgtg     2555

ctcatgtatg tgcgaagtat ataaattggc ttttcatgcg tgtgtgttgt ctgaacatgg     2615

ggagtgtttc atgggttatg tgtatgtgcc atttatgtga gtgtgtgttt gtgctgatga     2675

gaatactgag tatgtggaag gcagcagagc ggactggtga ggagcacagc tcaggaacta     2735

gactgcctgg gttccaatcc tggctctgtg gcttgctagc tatgtgacct tgagcaaatt     2795

accctcctta aacaagagtt ttcttccttg taaattacat ctgtcatggt ttcttggagg     2855

gcccacttgt atcctctggt tcttcattta ttgagcacct actacatgca aggcactgta     2915

ctaggcgtga gaagcatata gaggcaagaa agagatacca agatgccatc tgtgtcctgg     2975

ttagcagagc tggaccagtg gtgccttgga gggataagcc agctgcagct gggctgtgtg     3035

gttgacttat gggcccagcc agccaggctc aggccatggc tccccttttt cttcctcacc     3095

ctgatttctt gcttattcac tgaagttctc ctgaagagga actgggcctg ttgccctttc     3155

tgtaccattt atttgctccc aatgtttatg ataataaagg caccgctgat ggggacctcc     3215


<210>  84
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Gly Val Pro Phe Phe Ser Ser Leu Arg Cys Met Val Asp Leu Gly 
1               5                   10                  15      


Pro Cys Trp Ala Gly Gly Leu Thr Ala Glu Met Lys Leu Leu Leu Ala 
            20                  25                  30          


Leu Ala Gly Leu Leu Ala Ile Leu Ala Thr Pro Gln Pro Ser Glu Gly 
        35                  40                  45              


Ala Ala Pro Ala Val Leu Gly Glu Val Asp Thr Ser Leu Val Leu Ser 
    50                  55                  60                  


Ser Met Glu Glu Ala Lys Gln Leu Val Asp Lys Ala Tyr Lys Glu Arg 
65                  70                  75                  80  


Arg Glu Ser Ile Lys Gln Arg Leu Arg Ser Gly Ser Ala Ser Pro Met 
                85                  90                  95      


Glu Leu Leu Ser Tyr Phe Lys Gln Pro Val Ala Ala Thr Arg Thr Ala 
            100                 105                 110         


Val Arg Ala Ala Asp Tyr Leu His Val Ala Leu Asp Leu Leu Glu Arg 
        115                 120                 125             


Lys Leu Arg Ser Leu Trp Arg Arg Pro Phe Asn Val Thr Asp Val Leu 
    130                 135                 140                 


Thr Pro Ala Gln Leu Asn Val Leu Ser Lys Ser Ser Gly Cys Ala Tyr 
145                 150                 155                 160 


Gln Asp Val Gly Val Thr Cys Pro Glu Gln Asp Lys Tyr Arg Thr Ile 
                165                 170                 175     


Thr Gly Met Cys Asn Asn Arg Arg Ser Pro Thr Leu Gly Ala Ser Asn 
            180                 185                 190         


Arg Ala Phe Val Arg Trp Leu Pro Ala Glu Tyr Glu Asp Gly Phe Ser 
        195                 200                 205             


Leu Pro Tyr Gly Trp Thr Pro Gly Val Lys Arg Asn Gly Phe Pro Val 
    210                 215                 220                 


Ala Leu Ala Arg Ala Val Ser Asn Glu Ile Val Arg Phe Pro Thr Asp 
225                 230                 235                 240 


Gln Leu Thr Pro Asp Gln Glu Arg Ser Leu Met Phe Met Gln Trp Gly 
                245                 250                 255     


Gln Leu Leu Asp His Asp Leu Asp Phe Thr Pro Glu Pro Ala Ala Arg 
            260                 265                 270         


Ala Ser Phe Val Thr Gly Val Asn Cys Glu Thr Ser Cys Val Gln Gln 
        275                 280                 285             


Pro Pro Cys Phe Pro Leu Lys Ile Pro Pro Asn Asp Pro Arg Ile Lys 
    290                 295                 300                 


Asn Gln Ala Asp Cys Ile Pro Phe Phe Arg Ser Cys Pro Ala Cys Pro 
305                 310                 315                 320 


Gly Ser Asn Ile Thr Ile Arg Asn Gln Ile Asn Ala Leu Thr Ser Phe 
                325                 330                 335     


Val Asp Ala Ser Met Val Tyr Gly Ser Glu Glu Pro Leu Ala Arg Asn 
            340                 345                 350         


Leu Arg Asn Met Ser Asn Gln Leu Gly Leu Leu Ala Val Asn Gln Arg 
        355                 360                 365             


Phe Gln Asp Asn Gly Arg Ala Leu Leu Pro Phe Asp Asn Leu His Asp 
    370                 375                 380                 


Asp Pro Cys Leu Leu Thr Asn Arg Ser Ala Arg Ile Pro Cys Phe Leu 
385                 390                 395                 400 


Ala Gly Asp Thr Arg Ser Ser Glu Met Pro Glu Leu Thr Ser Met His 
                405                 410                 415     


Thr Leu Leu Leu Arg Glu His Asn Arg Leu Ala Thr Glu Leu Lys Ser 
            420                 425                 430         


Leu Asn Pro Arg Trp Asp Gly Glu Arg Leu Tyr Gln Glu Ala Arg Lys 
        435                 440                 445             


Ile Val Gly Ala Met Val Gln Ile Ile Thr Tyr Arg Asp Tyr Leu Pro 
    450                 455                 460                 


Leu Val Leu Gly Pro Thr Ala Met Arg Lys Tyr Leu Pro Thr Tyr Arg 
465                 470                 475                 480 


Ser Tyr Asn Asp Ser Val Asp Pro Arg Ile Ala Asn Val Phe Thr Asn 
                485                 490                 495     


Ala Phe Arg Tyr Gly His Thr Leu Ile Gln Pro Phe Met Phe Arg Leu 
            500                 505                 510         


Asp Asn Arg Tyr Gln Pro Met Glu Pro Asn Pro Arg Val Pro Leu Ser 
        515                 520                 525             


Arg Val Phe Phe Ala Ser Trp Arg Val Val Leu Glu Gly Gly Ile Asp 
    530                 535                 540                 


Pro Ile Leu Arg Gly Leu Met Ala Thr Pro Ala Lys Leu Asn Arg Gln 
545                 550                 555                 560 


Asn Gln Ile Ala Val Asp Glu Ile Arg Glu Arg Leu Phe Glu Gln Val 
                565                 570                 575     


Met Arg Ile Gly Leu Asp Leu Pro Ala Leu Asn Met Gln Arg Ser Arg 
            580                 585                 590         


Asp His Gly Leu Pro Gly Tyr Asn Ala Trp Arg Arg Phe Cys Gly Leu 
        595                 600                 605             


Pro Gln Pro Glu Thr Val Gly Gln Leu Gly Thr Val Leu Arg Asn Leu 
    610                 615                 620                 


Lys Leu Ala Arg Lys Leu Met Glu Gln Tyr Gly Thr Pro Asn Asn Ile 
625                 630                 635                 640 


Asp Ile Trp Met Gly Gly Val Ser Glu Pro Leu Lys Arg Lys Gly Arg 
                645                 650                 655     


Val Gly Pro Leu Leu Ala Cys Ile Ile Gly Thr Gln Phe Arg Lys Leu 
            660                 665                 670         


Arg Asp Gly Asp Arg Phe Trp Trp Glu Asn Glu Gly Val Phe Ser Met 
        675                 680                 685             


Gln Gln Arg Gln Ala Leu Ala Gln Ile Ser Leu Pro Arg Ile Ile Cys 
    690                 695                 700                 


Asp Asn Thr Gly Ile Thr Thr Val Ser Lys Asn Asn Ile Phe Met Ser 
705                 710                 715                 720 


Asn Ser Tyr Pro Arg Asp Phe Val Asn Cys Ser Thr Leu Pro Ala Leu 
                725                 730                 735     


Asn Leu Ala Ser Trp Arg Glu Ala Ser 
            740                 745 


<210>  85
<211>  3376
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (136)..(3168)

<400>  85
agtgaggggc ggtgccgcgc tggtcccgcg ccggtcccgg tgggccgact tccggcgagc       60

gggcaagcgg gaaccaggtg gccacccggt gtcggtttca ttttcctttg gaatttctgc      120

tttacagaca gaaca atg gca gcc cga gta ctt ata att ggc agt gga gga       171
                 Met Ala Ala Arg Val Leu Ile Ile Gly Ser Gly Gly          
                 1               5                   10                   

agg gaa cat acg ctg gcc tgg aaa ctt gca cag tct cat cat gtc aaa        219
Arg Glu His Thr Leu Ala Trp Lys Leu Ala Gln Ser His His Val Lys           
        15                  20                  25                        

caa gtg ttg gtt gcc cca gga aac gca ggc act gcc tgc tct gaa aag        267
Gln Val Leu Val Ala Pro Gly Asn Ala Gly Thr Ala Cys Ser Glu Lys           
    30                  35                  40                            

att tca aat acc gcc atc tca atc agt gac cac act gcc ctt gct caa        315
Ile Ser Asn Thr Ala Ile Ser Ile Ser Asp His Thr Ala Leu Ala Gln           
45                  50                  55                  60            

ttc tgc aaa gag aag aaa att gaa ttt gta gtt gtt gga cca gaa gca        363
Phe Cys Lys Glu Lys Lys Ile Glu Phe Val Val Val Gly Pro Glu Ala           
                65                  70                  75                

cct ctg gct gct ggg att gtt ggg aac ctg agg tct gca gga gtg caa        411
Pro Leu Ala Ala Gly Ile Val Gly Asn Leu Arg Ser Ala Gly Val Gln           
            80                  85                  90                    

tgc ttt ggc cca aca gca gaa gcg gct cag tta gag tcc agc aaa agg        459
Cys Phe Gly Pro Thr Ala Glu Ala Ala Gln Leu Glu Ser Ser Lys Arg           
        95                  100                 105                       

ttt gcc aaa gag ttt atg gac aga cat gga atc cca acc gca caa tgg        507
Phe Ala Lys Glu Phe Met Asp Arg His Gly Ile Pro Thr Ala Gln Trp           
    110                 115                 120                           

aag gct ttc acc aaa cct gaa gaa gcc tgc agc ttc att ttg agt gca        555
Lys Ala Phe Thr Lys Pro Glu Glu Ala Cys Ser Phe Ile Leu Ser Ala           
125                 130                 135                 140           

gac ttc cct gct ttg gtt gtg aag gcc agt ggt ctt gca gct gga aaa        603
Asp Phe Pro Ala Leu Val Val Lys Ala Ser Gly Leu Ala Ala Gly Lys           
                145                 150                 155               

ggg gtg att gtt gca aag agc aaa gaa gag gcc tgc aaa gct gta caa        651
Gly Val Ile Val Ala Lys Ser Lys Glu Glu Ala Cys Lys Ala Val Gln           
            160                 165                 170                   

gag atc atg cag gag aaa gcc ttt ggg gca gct gga gaa aca att gtc        699
Glu Ile Met Gln Glu Lys Ala Phe Gly Ala Ala Gly Glu Thr Ile Val           
        175                 180                 185                       

att gaa gaa ctt ctt gac gga gaa gag gtg tcg tgt ctg tgt ttc act        747
Ile Glu Glu Leu Leu Asp Gly Glu Glu Val Ser Cys Leu Cys Phe Thr           
    190                 195                 200                           

gat ggc aag act gtg gcc ccc atg ccc cca gca cag gac cat aag cga        795
Asp Gly Lys Thr Val Ala Pro Met Pro Pro Ala Gln Asp His Lys Arg           
205                 210                 215                 220           

tta ctg gag gga gat ggt ggc cct aac aca ggg gga atg gga gcc tat        843
Leu Leu Glu Gly Asp Gly Gly Pro Asn Thr Gly Gly Met Gly Ala Tyr           
                225                 230                 235               

tgt cca gcc cct cag gtt tct aat gat cta tta cta aaa att aaa gat        891
Cys Pro Ala Pro Gln Val Ser Asn Asp Leu Leu Leu Lys Ile Lys Asp           
            240                 245                 250                   

act gtt ctt cag agg aca gtg gat ggc atg cag caa gag ggt act cca        939
Thr Val Leu Gln Arg Thr Val Asp Gly Met Gln Gln Glu Gly Thr Pro           
        255                 260                 265                       

tat aca ggt att ctc tat gct gga ata atg ctg acc aag aat ggc cca        987
Tyr Thr Gly Ile Leu Tyr Ala Gly Ile Met Leu Thr Lys Asn Gly Pro           
    270                 275                 280                           

aaa gtt cta gag ttt aat tgc cgt ttt ggt gat cca gag tgc caa gta       1035
Lys Val Leu Glu Phe Asn Cys Arg Phe Gly Asp Pro Glu Cys Gln Val           
285                 290                 295                 300           

atc ctc cca ctt ctt aaa agt gat ctt tat gaa gtg att cag tcc acc       1083
Ile Leu Pro Leu Leu Lys Ser Asp Leu Tyr Glu Val Ile Gln Ser Thr           
                305                 310                 315               

tta gat gga ctg ctc tgc aca tct ctg cct gtt tgg cta gaa aac cac       1131
Leu Asp Gly Leu Leu Cys Thr Ser Leu Pro Val Trp Leu Glu Asn His           
            320                 325                 330                   

acc gcc cta act gtt gtc atg gca agt aaa ggt tat cct gga gac tac       1179
Thr Ala Leu Thr Val Val Met Ala Ser Lys Gly Tyr Pro Gly Asp Tyr           
        335                 340                 345                       

acc aag ggt gta gag ata aca ggg ttt cct gag gct caa gct cta gga       1227
Thr Lys Gly Val Glu Ile Thr Gly Phe Pro Glu Ala Gln Ala Leu Gly           
    350                 355                 360                           

ctg gag gtg ttc cat gca ggc act gcc ctc aaa aat ggc aaa gta gta       1275
Leu Glu Val Phe His Ala Gly Thr Ala Leu Lys Asn Gly Lys Val Val           
365                 370                 375                 380           

act cat ggg ggt aga gtt ctt gca gtc aca gcc atc cgg gaa aat ctc       1323
Thr His Gly Gly Arg Val Leu Ala Val Thr Ala Ile Arg Glu Asn Leu           
                385                 390                 395               

ata tca gcc ctt gag gaa gcc aag aaa gga cta gct gct ata aag ttt       1371
Ile Ser Ala Leu Glu Glu Ala Lys Lys Gly Leu Ala Ala Ile Lys Phe           
            400                 405                 410                   

gag gga gca att tat agg aaa gac gtc ggc ttt cgt gcc ata gct ttc       1419
Glu Gly Ala Ile Tyr Arg Lys Asp Val Gly Phe Arg Ala Ile Ala Phe           
        415                 420                 425                       

ctc cag cag ccc agg agt ttg act tac aag gaa tct gga gta gat atc       1467
Leu Gln Gln Pro Arg Ser Leu Thr Tyr Lys Glu Ser Gly Val Asp Ile           
    430                 435                 440                           

gca gct gga aat atg ctg gtc aag aaa att cag cct tta gca aaa gcc       1515
Ala Ala Gly Asn Met Leu Val Lys Lys Ile Gln Pro Leu Ala Lys Ala           
445                 450                 455                 460           

act tcc aga tca ggc tgt aaa gtt gat ctt gga ggt ttt gct ggt ctt       1563
Thr Ser Arg Ser Gly Cys Lys Val Asp Leu Gly Gly Phe Ala Gly Leu           
                465                 470                 475               

ttt gat tta aaa gca gct ggt ttc aaa gat ccc ctt ctg gcc tct gga       1611
Phe Asp Leu Lys Ala Ala Gly Phe Lys Asp Pro Leu Leu Ala Ser Gly           
            480                 485                 490                   

aca gat ggc gtt gga act aaa cta aag att gcc cag cta tgc aat aaa       1659
Thr Asp Gly Val Gly Thr Lys Leu Lys Ile Ala Gln Leu Cys Asn Lys           
        495                 500                 505                       

cat gat acc att ggt caa gat ttg gta gca atg tgt gtt aat gat att       1707
His Asp Thr Ile Gly Gln Asp Leu Val Ala Met Cys Val Asn Asp Ile           
    510                 515                 520                           

ctg gca caa gga gca gag ccc ctc ttc ttc ctt gat tac ttt tcc tgt       1755
Leu Ala Gln Gly Ala Glu Pro Leu Phe Phe Leu Asp Tyr Phe Ser Cys           
525                 530                 535                 540           

gga aaa ctt gac ctc agt gta act gaa gct gtt gtt gct gga att gct       1803
Gly Lys Leu Asp Leu Ser Val Thr Glu Ala Val Val Ala Gly Ile Ala           
                545                 550                 555               

aaa gct tgt gga aaa gct gga tgt gct ctc ctt gga ggt gaa aca gca       1851
Lys Ala Cys Gly Lys Ala Gly Cys Ala Leu Leu Gly Gly Glu Thr Ala           
            560                 565                 570                   

gaa atg cct gac atg tat ccc cct gga gag tat gac cta gct ggg ttt       1899
Glu Met Pro Asp Met Tyr Pro Pro Gly Glu Tyr Asp Leu Ala Gly Phe           
        575                 580                 585                       

gcc gtt ggt gcc atg gag cga gat cag aaa ctc cct cac ctg gaa aga       1947
Ala Val Gly Ala Met Glu Arg Asp Gln Lys Leu Pro His Leu Glu Arg           
    590                 595                 600                           

atc act gag ggt gat gtt gtt gtt gga ata gct tca tct ggt ctt cat       1995
Ile Thr Glu Gly Asp Val Val Val Gly Ile Ala Ser Ser Gly Leu His           
605                 610                 615                 620           

agc aat gga ttt agc ctt gtg agg aaa atc gtg gca aaa tct tcc ctc       2043
Ser Asn Gly Phe Ser Leu Val Arg Lys Ile Val Ala Lys Ser Ser Leu           
                625                 630                 635               

cag tac tcc tct cca gca cct gat ggt tgt ggt gac cag act tta ggg       2091
Gln Tyr Ser Ser Pro Ala Pro Asp Gly Cys Gly Asp Gln Thr Leu Gly           
            640                 645                 650                   

gac tta ctt ctc acg cct acc aga atc tac agc cat tca ctg tta cct       2139
Asp Leu Leu Leu Thr Pro Thr Arg Ile Tyr Ser His Ser Leu Leu Pro           
        655                 660                 665                       

gtc cta cgt tca gga cat gtc aaa gcc ttt gcc cat att act ggt gga       2187
Val Leu Arg Ser Gly His Val Lys Ala Phe Ala His Ile Thr Gly Gly           
    670                 675                 680                           

gga tta cta gag aac atc ccc aga gtc ctc cct gag aaa ctt ggg gta       2235
Gly Leu Leu Glu Asn Ile Pro Arg Val Leu Pro Glu Lys Leu Gly Val           
685                 690                 695                 700           

gat tta gat gcc cag acc tgg agg atc ccc agg gtc ttc tca tgg ttg       2283
Asp Leu Asp Ala Gln Thr Trp Arg Ile Pro Arg Val Phe Ser Trp Leu           
                705                 710                 715               

cag cag gaa gga cac ctc tct gag gaa gag atg gcc aga aca ttt aac       2331
Gln Gln Glu Gly His Leu Ser Glu Glu Glu Met Ala Arg Thr Phe Asn           
            720                 725                 730                   

tgt ggg gtt ggc gct gtc ctt gtg gta tca aag gag cag aca gag cag       2379
Cys Gly Val Gly Ala Val Leu Val Val Ser Lys Glu Gln Thr Glu Gln           
        735                 740                 745                       

att ctg agg gat atc cag cag cac aag gaa gaa gcc tgg gtg att ggc       2427
Ile Leu Arg Asp Ile Gln Gln His Lys Glu Glu Ala Trp Val Ile Gly           
    750                 755                 760                           

agt gtg gtt gca cga gct gaa ggt tcc cca cgt gtg aaa gtc aag aat       2475
Ser Val Val Ala Arg Ala Glu Gly Ser Pro Arg Val Lys Val Lys Asn           
765                 770                 775                 780           

ctg att gaa agc atg caa ata aat ggg tca gtg ttg aag aat ggc tcc       2523
Leu Ile Glu Ser Met Gln Ile Asn Gly Ser Val Leu Lys Asn Gly Ser           
                785                 790                 795               

ctg aca aat cat ttc tct ttt gaa aaa aaa aag gcc aga gtg gct gtc       2571
Leu Thr Asn His Phe Ser Phe Glu Lys Lys Lys Ala Arg Val Ala Val           
            800                 805                 810                   

tta ata tct gga aca gga tcg aac ctg caa gca ctt ata gac agt act       2619
Leu Ile Ser Gly Thr Gly Ser Asn Leu Gln Ala Leu Ile Asp Ser Thr           
        815                 820                 825                       

cgg gaa cca aat agc tct gca caa att gat att gtt atc tcc aac aaa       2667
Arg Glu Pro Asn Ser Ser Ala Gln Ile Asp Ile Val Ile Ser Asn Lys           
    830                 835                 840                           

gcc gca gta gct ggg tta gat aaa gcg gaa aga gct ggt att ccc act       2715
Ala Ala Val Ala Gly Leu Asp Lys Ala Glu Arg Ala Gly Ile Pro Thr           
845                 850                 855                 860           

aga gta att aat cat aaa ctg tat aaa aat cgt gta gaa ttt gac agt       2763
Arg Val Ile Asn His Lys Leu Tyr Lys Asn Arg Val Glu Phe Asp Ser           
                865                 870                 875               

gca att gac cta gtc ctt gaa gag ttc tcc ata gac ata gtc tgt ctt       2811
Ala Ile Asp Leu Val Leu Glu Glu Phe Ser Ile Asp Ile Val Cys Leu           
            880                 885                 890                   

gca gga ttc atg aga att ctt tct ggc ccc ttt gtc caa aag tgg aat       2859
Ala Gly Phe Met Arg Ile Leu Ser Gly Pro Phe Val Gln Lys Trp Asn           
        895                 900                 905                       

gga aaa atg ctc aat atc cac cca tcc ttg ctc cct tct ttt aag ggt       2907
Gly Lys Met Leu Asn Ile His Pro Ser Leu Leu Pro Ser Phe Lys Gly           
    910                 915                 920                           

tca aat gcc cat gag caa gcc ctg gaa acc gga gtc aca gtt act ggg       2955
Ser Asn Ala His Glu Gln Ala Leu Glu Thr Gly Val Thr Val Thr Gly           
925                 930                 935                 940           

tgc act gta cac ttt gta gct gaa gat gtg gat gct gga cag att att       3003
Cys Thr Val His Phe Val Ala Glu Asp Val Asp Ala Gly Gln Ile Ile           
                945                 950                 955               

ttg caa gaa gct gtt ccc gtg aag agg ggt gat act gtc gca act ctt       3051
Leu Gln Glu Ala Val Pro Val Lys Arg Gly Asp Thr Val Ala Thr Leu           
            960                 965                 970                   

tct gaa aga gta aaa tta gca gaa cat aaa ata ttt cct gca gcc ctt       3099
Ser Glu Arg Val Lys Leu Ala Glu His Lys Ile Phe Pro Ala Ala Leu           
        975                 980                 985                       

cag ctg gtg gcc agt gga act gta cag ctt gga gaa  aat ggc aag atc      3147
Gln Leu Val Ala Ser Gly Thr Val Gln Leu Gly Glu  Asn Gly Lys Ile          
    990                 995                 1000                          

tgt  tgg gtt aaa gag gaa  tga agccttttaa ttcagaaatg gggccagttt        3198
Cys  Trp Val Lys Glu Glu                                                  
1005                 1010                                                 

agaaagaatt atttgctgtt tgcatggtgg ttttttatca tggacttggc ccaaaagaaa     3258

aactgctaaa agacaaaaaa gacctcaccc ttacttcatc tattttttta ataaatagag     3318

actcactaaa aacaagacta gttagtgcag catatctgag acaaaaaaaa aaaaaaaa       3376


<210>  86
<211>  1010
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ala Ala Arg Val Leu Ile Ile Gly Ser Gly Gly Arg Glu His Thr 
1               5                   10                  15      


Leu Ala Trp Lys Leu Ala Gln Ser His His Val Lys Gln Val Leu Val 
            20                  25                  30          


Ala Pro Gly Asn Ala Gly Thr Ala Cys Ser Glu Lys Ile Ser Asn Thr 
        35                  40                  45              


Ala Ile Ser Ile Ser Asp His Thr Ala Leu Ala Gln Phe Cys Lys Glu 
    50                  55                  60                  


Lys Lys Ile Glu Phe Val Val Val Gly Pro Glu Ala Pro Leu Ala Ala 
65                  70                  75                  80  


Gly Ile Val Gly Asn Leu Arg Ser Ala Gly Val Gln Cys Phe Gly Pro 
                85                  90                  95      


Thr Ala Glu Ala Ala Gln Leu Glu Ser Ser Lys Arg Phe Ala Lys Glu 
            100                 105                 110         


Phe Met Asp Arg His Gly Ile Pro Thr Ala Gln Trp Lys Ala Phe Thr 
        115                 120                 125             


Lys Pro Glu Glu Ala Cys Ser Phe Ile Leu Ser Ala Asp Phe Pro Ala 
    130                 135                 140                 


Leu Val Val Lys Ala Ser Gly Leu Ala Ala Gly Lys Gly Val Ile Val 
145                 150                 155                 160 


Ala Lys Ser Lys Glu Glu Ala Cys Lys Ala Val Gln Glu Ile Met Gln 
                165                 170                 175     


Glu Lys Ala Phe Gly Ala Ala Gly Glu Thr Ile Val Ile Glu Glu Leu 
            180                 185                 190         


Leu Asp Gly Glu Glu Val Ser Cys Leu Cys Phe Thr Asp Gly Lys Thr 
        195                 200                 205             


Val Ala Pro Met Pro Pro Ala Gln Asp His Lys Arg Leu Leu Glu Gly 
    210                 215                 220                 


Asp Gly Gly Pro Asn Thr Gly Gly Met Gly Ala Tyr Cys Pro Ala Pro 
225                 230                 235                 240 


Gln Val Ser Asn Asp Leu Leu Leu Lys Ile Lys Asp Thr Val Leu Gln 
                245                 250                 255     


Arg Thr Val Asp Gly Met Gln Gln Glu Gly Thr Pro Tyr Thr Gly Ile 
            260                 265                 270         


Leu Tyr Ala Gly Ile Met Leu Thr Lys Asn Gly Pro Lys Val Leu Glu 
        275                 280                 285             


Phe Asn Cys Arg Phe Gly Asp Pro Glu Cys Gln Val Ile Leu Pro Leu 
    290                 295                 300                 


Leu Lys Ser Asp Leu Tyr Glu Val Ile Gln Ser Thr Leu Asp Gly Leu 
305                 310                 315                 320 


Leu Cys Thr Ser Leu Pro Val Trp Leu Glu Asn His Thr Ala Leu Thr 
                325                 330                 335     


Val Val Met Ala Ser Lys Gly Tyr Pro Gly Asp Tyr Thr Lys Gly Val 
            340                 345                 350         


Glu Ile Thr Gly Phe Pro Glu Ala Gln Ala Leu Gly Leu Glu Val Phe 
        355                 360                 365             


His Ala Gly Thr Ala Leu Lys Asn Gly Lys Val Val Thr His Gly Gly 
    370                 375                 380                 


Arg Val Leu Ala Val Thr Ala Ile Arg Glu Asn Leu Ile Ser Ala Leu 
385                 390                 395                 400 


Glu Glu Ala Lys Lys Gly Leu Ala Ala Ile Lys Phe Glu Gly Ala Ile 
                405                 410                 415     


Tyr Arg Lys Asp Val Gly Phe Arg Ala Ile Ala Phe Leu Gln Gln Pro 
            420                 425                 430         


Arg Ser Leu Thr Tyr Lys Glu Ser Gly Val Asp Ile Ala Ala Gly Asn 
        435                 440                 445             


Met Leu Val Lys Lys Ile Gln Pro Leu Ala Lys Ala Thr Ser Arg Ser 
    450                 455                 460                 


Gly Cys Lys Val Asp Leu Gly Gly Phe Ala Gly Leu Phe Asp Leu Lys 
465                 470                 475                 480 


Ala Ala Gly Phe Lys Asp Pro Leu Leu Ala Ser Gly Thr Asp Gly Val 
                485                 490                 495     


Gly Thr Lys Leu Lys Ile Ala Gln Leu Cys Asn Lys His Asp Thr Ile 
            500                 505                 510         


Gly Gln Asp Leu Val Ala Met Cys Val Asn Asp Ile Leu Ala Gln Gly 
        515                 520                 525             


Ala Glu Pro Leu Phe Phe Leu Asp Tyr Phe Ser Cys Gly Lys Leu Asp 
    530                 535                 540                 


Leu Ser Val Thr Glu Ala Val Val Ala Gly Ile Ala Lys Ala Cys Gly 
545                 550                 555                 560 


Lys Ala Gly Cys Ala Leu Leu Gly Gly Glu Thr Ala Glu Met Pro Asp 
                565                 570                 575     


Met Tyr Pro Pro Gly Glu Tyr Asp Leu Ala Gly Phe Ala Val Gly Ala 
            580                 585                 590         


Met Glu Arg Asp Gln Lys Leu Pro His Leu Glu Arg Ile Thr Glu Gly 
        595                 600                 605             


Asp Val Val Val Gly Ile Ala Ser Ser Gly Leu His Ser Asn Gly Phe 
    610                 615                 620                 


Ser Leu Val Arg Lys Ile Val Ala Lys Ser Ser Leu Gln Tyr Ser Ser 
625                 630                 635                 640 


Pro Ala Pro Asp Gly Cys Gly Asp Gln Thr Leu Gly Asp Leu Leu Leu 
                645                 650                 655     


Thr Pro Thr Arg Ile Tyr Ser His Ser Leu Leu Pro Val Leu Arg Ser 
            660                 665                 670         


Gly His Val Lys Ala Phe Ala His Ile Thr Gly Gly Gly Leu Leu Glu 
        675                 680                 685             


Asn Ile Pro Arg Val Leu Pro Glu Lys Leu Gly Val Asp Leu Asp Ala 
    690                 695                 700                 


Gln Thr Trp Arg Ile Pro Arg Val Phe Ser Trp Leu Gln Gln Glu Gly 
705                 710                 715                 720 


His Leu Ser Glu Glu Glu Met Ala Arg Thr Phe Asn Cys Gly Val Gly 
                725                 730                 735     


Ala Val Leu Val Val Ser Lys Glu Gln Thr Glu Gln Ile Leu Arg Asp 
            740                 745                 750         


Ile Gln Gln His Lys Glu Glu Ala Trp Val Ile Gly Ser Val Val Ala 
        755                 760                 765             


Arg Ala Glu Gly Ser Pro Arg Val Lys Val Lys Asn Leu Ile Glu Ser 
    770                 775                 780                 


Met Gln Ile Asn Gly Ser Val Leu Lys Asn Gly Ser Leu Thr Asn His 
785                 790                 795                 800 


Phe Ser Phe Glu Lys Lys Lys Ala Arg Val Ala Val Leu Ile Ser Gly 
                805                 810                 815     


Thr Gly Ser Asn Leu Gln Ala Leu Ile Asp Ser Thr Arg Glu Pro Asn 
            820                 825                 830         


Ser Ser Ala Gln Ile Asp Ile Val Ile Ser Asn Lys Ala Ala Val Ala 
        835                 840                 845             


Gly Leu Asp Lys Ala Glu Arg Ala Gly Ile Pro Thr Arg Val Ile Asn 
    850                 855                 860                 


His Lys Leu Tyr Lys Asn Arg Val Glu Phe Asp Ser Ala Ile Asp Leu 
865                 870                 875                 880 


Val Leu Glu Glu Phe Ser Ile Asp Ile Val Cys Leu Ala Gly Phe Met 
                885                 890                 895     


Arg Ile Leu Ser Gly Pro Phe Val Gln Lys Trp Asn Gly Lys Met Leu 
            900                 905                 910         


Asn Ile His Pro Ser Leu Leu Pro Ser Phe Lys Gly Ser Asn Ala His 
        915                 920                 925             


Glu Gln Ala Leu Glu Thr Gly Val Thr Val Thr Gly Cys Thr Val His 
    930                 935                 940                 


Phe Val Ala Glu Asp Val Asp Ala Gly Gln Ile Ile Leu Gln Glu Ala 
945                 950                 955                 960 


Val Pro Val Lys Arg Gly Asp Thr Val Ala Thr Leu Ser Glu Arg Val 
                965                 970                 975     


Lys Leu Ala Glu His Lys Ile Phe Pro Ala Ala Leu Gln Leu Val Ala 
            980                 985                 990         


Ser Gly Thr Val Gln Leu Gly Glu  Asn Gly Lys Ile Cys  Trp Val Lys 
        995                 1000                 1005             


Glu Glu  
    1010 


<210>  87
<211>  4482
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (105)..(1304)

<400>  87
tgaggagccg cccggtcgcc tgcgcgctcc ctccggcggc gtccccagcc cgcggcccct       60

ctgctgccgg cccccggctc gccggctgcg ggagtggcct caag atg gat gaa gac       116
                                                 Met Asp Glu Asp          
                                                 1                        

ggc ggc ggc gag ggt ggt ggc gtg cct gaa gac ctc tca tta gaa gag        164
Gly Gly Gly Glu Gly Gly Gly Val Pro Glu Asp Leu Ser Leu Glu Glu           
5                   10                  15                  20            

aga gaa gaa ctt cta gac att cgt cga aga aaa aag gaa ctt att gat        212
Arg Glu Glu Leu Leu Asp Ile Arg Arg Arg Lys Lys Glu Leu Ile Asp           
                25                  30                  35                

gac att gag agg ctg aaa tat gaa att gca gag gtg atg aca gag atc        260
Asp Ile Glu Arg Leu Lys Tyr Glu Ile Ala Glu Val Met Thr Glu Ile           
            40                  45                  50                    

gac aat cta act tcc gta gag gag agc aaa acg act cag agg aac aaa        308
Asp Asn Leu Thr Ser Val Glu Glu Ser Lys Thr Thr Gln Arg Asn Lys           
        55                  60                  65                        

cag ata gcc atg gga aga aag aaa ttc aac atg gat ccc aaa aag gga        356
Gln Ile Ala Met Gly Arg Lys Lys Phe Asn Met Asp Pro Lys Lys Gly           
    70                  75                  80                            

att cag ttt cta ata gaa aat gac ctg cta cag agt tcc cca gaa gac        404
Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Gln Ser Ser Pro Glu Asp           
85                  90                  95                  100           

gtc gcc cag ttc ctt tat aaa gga gaa ggc cta aat aag acc gtc att        452
Val Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Thr Val Ile           
                105                 110                 115               

ggg gac tac ctg ggt gaa agg gat gaa ttt aat att aaa gtt ctt caa        500
Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn Ile Lys Val Leu Gln           
            120                 125                 130                   

gcc ttt gtt gaa ctc cat gag ttt gct gat ctc aac ctt gta caa gcc        548
Ala Phe Val Glu Leu His Glu Phe Ala Asp Leu Asn Leu Val Gln Ala           
        135                 140                 145                       

tta agg cag ttc tta tgg agc ttc agg ctg ccc ggg gag gcg cag aag        596
Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu Ala Gln Lys           
    150                 155                 160                           

att gat cgc atg atg gag gct ttc gct tct cgc tac tgc ctg tgc aac        644
Ile Asp Arg Met Met Glu Ala Phe Ala Ser Arg Tyr Cys Leu Cys Asn           
165                 170                 175                 180           

ccc ggg gtc ttc cag tcc aca gac acg tgc tac gtg ctg tca ttc gcc        692
Pro Gly Val Phe Gln Ser Thr Asp Thr Cys Tyr Val Leu Ser Phe Ala           
                185                 190                 195               

atc atc atg ctc aac acc agc ctc cac aac cac aac gtg cgt gac aag        740
Ile Ile Met Leu Asn Thr Ser Leu His Asn His Asn Val Arg Asp Lys           
            200                 205                 210                   

ccc acg gca gaa cgg ttc atc gcc atg aac cgc ggc atc aac gag ggc        788
Pro Thr Ala Glu Arg Phe Ile Ala Met Asn Arg Gly Ile Asn Glu Gly           
        215                 220                 225                       

ggg gac ctc cct gag gag ctg ctg agg aat ttg tat gag agc att aag        836
Gly Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr Glu Ser Ile Lys           
    230                 235                 240                           

aac gag cca ttt aag atc ccg gag gac gac ggg aac gac ctg acc cac        884
Asn Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn Asp Leu Thr His           
245                 250                 255                 260           

acc ttc ttc aac ccc gac cgc gag ggc tgg ctc ctg aag ctg gga ggg        932
Thr Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Gly           
                265                 270                 275               

cgt gtg aag acc tgg aag cgc cgg tgg ttc atc ctg acc gat aac tgc        980
Arg Val Lys Thr Trp Lys Arg Arg Trp Phe Ile Leu Thr Asp Asn Cys           
            280                 285                 290                   

ctc tat tac ttt gaa tac aca aca gat aag gag ccc agg gga atc atc       1028
Leu Tyr Tyr Phe Glu Tyr Thr Thr Asp Lys Glu Pro Arg Gly Ile Ile           
        295                 300                 305                       

ccg ttg gaa aac ctc agc atc agg gag gtg gag gac ccc cgg aaa ccc       1076
Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Glu Asp Pro Arg Lys Pro           
    310                 315                 320                           

aac tgt ttt gag ctc tac aat ccc agc cac aaa ggg cag gtc atc aag       1124
Asn Cys Phe Glu Leu Tyr Asn Pro Ser His Lys Gly Gln Val Ile Lys           
325                 330                 335                 340           

gcc tgt aag act gag gcc gac ggc cgc gtg gta gag ggg aac cat gtg       1172
Ala Cys Lys Thr Glu Ala Asp Gly Arg Val Val Glu Gly Asn His Val           
                345                 350                 355               

gtg tac cgg atc tca gcc ccg agc ccg gag gag aag gag gag tgg atg       1220
Val Tyr Arg Ile Ser Ala Pro Ser Pro Glu Glu Lys Glu Glu Trp Met           
            360                 365                 370                   

aaa tcc atc aaa gcc agt atc agc aga gat ccc ttc tat gac atg ttg       1268
Lys Ser Ile Lys Ala Ser Ile Ser Arg Asp Pro Phe Tyr Asp Met Leu           
        375                 380                 385                       

gca acg agg aaa cga agg att gcc aat aaa aaa tag ctttcctggc            1314
Ala Thr Arg Lys Arg Arg Ile Ala Asn Lys Lys                               
    390                 395                                               

taaaagaccc aggtaaaaga cccaacccca gcagaaagac accgcgggcg gcccctccgc     1374

ggaaggcgtg gcagggaggc agtcgccctg cggtgcaagc tgctgctcca gagcataccg     1434

tggcccaggt ggtatcccca aggcctcgtg ccgtggctgg ggtcctggga ggtggtcgcc     1494

ctgcagtgca agctgctgct ccagagcgta ccgtggccca gactgatcct cgaggcctcc     1554

tgccgtggct ggggtcatgg tcggctgcgc atgtccagaa gcatttcctt cctgcgacca     1614

tcccggcgcc cctaggggga gaagccagga cagcagcttc cgctgtctcc acagcagaca     1674

cgggacggat tccacagacg ggagcctcat tcgtaccatg ccaaacgcat tcactcgggg     1734

cagtattaac cgttctagaa agccactgtt ttatagcaaa acaggaaagg aaaagctacc     1794

agttttttat tcagaatttt tctcagatat ataggattat agcttttata tgccttttta     1854

tattctgaaa ttataacaaa agatactttc taacagtagt atttttagaa tggcagctat     1914

aaagttaact cctggacaca agtatatact gtgcactgaa aaaatatcca tctacacagc     1974

acccaagggg agggctgggg gcaccggcac gggggcagcg tgcagccctg ccctgtcagg     2034

ctgtcagaca agccccgggg ggcagcaggt gggctcggga cgggctgggg gagggacggc     2094

catggcactt gggggctcca gggtgactcc catgaggcct cccttcaacc aggctttttg     2154

gccccacaaa tactttaagc aaatcattaa aattataaca gttaatggtt tgggggtgtt     2214

taggctgtaa ctgctaactc ctaggaaaca gccttttccc tggacacaga tggtccatac     2274

gctgagccac gtgaaactgc tgatgttttg tttagatgca cacacatggc agcgtttcat     2334

acaggtcagc aggttagacc ggcttttgac catattcatc gctatttaaa acctgtggca     2394

aaatgaacgc ttattttaca gactttctaa tttgaccaga tttcttaatg aatagacaca     2454

gaattaacta aaaacagtct caccccatgt agtgcgccgt gtcctgagag aggtgccctc     2514

cctacgagga gggaagaaca ggccctgggg tgcagaggcc cggcacgtag agaacccaga     2574

tagacgccgg tggtggaact ggtcaaactc cacgcccgcc tgggaggttg tcaggttgct     2634

gtggatgtaa ggataggagg tgcccagtgc tccgctcaag gaaggctgga tctgggcccc     2694

acctacagag agggctcagg gctggaccgg gggcattgtg tgcttgggcc gacccgggcc     2754

ggtggcagac gctgttctct gtcgggagat ttgcgtcccc aggaccctgt tacacagtgg     2814

gctgttgggt tggtggctgg cttttcctct atggacttcc tcttcctgcc ccacctgcat     2874

aggcacacac accttgaatc tgcaccctct ggagggcatc tgtactcctg tgcaaaatgc     2934

ccagtccaga gacaaaacct cagactttgt gcacctaggt ttccttctca gcagcggaga     2994

ctgttctttg agttgccttg aagtggaggc cgagcggctg cgggcccttc gcctccctgc     3054

ggctgacctt gatgtagctt taagtcacac tagactgcag aggggtccga ggccagaaac     3114

ccctgtcctg catcagactt tcattcccac gttcttaggc tttgttactg atacctcaaa     3174

tcggaagttt tagttctgag aaaggcaagt cagcgttctt gaaatgcctg actggtagat     3234

atgcaactct ggcctccagt cttccatgaa aataaatgct gcctggaccc ccacccagac     3294

cacacactga cggccggctc cggcggtgcc cacccctcag gctggcccgg cacccaagac     3354

tggccacagc cagctctgtc agcatgttgt gctcggacaa gctgtttcct tcttctgacc     3414

aacccaggtg tgacctgggg atgcagagct ttctgttttg ggtgttggga gaagcagcag     3474

gaaggagtcg ccagatgatc aagctccccc tttgctgtca tctgtgaatg agcttcgcca     3534

ggtggtgggc acctgggagc catgcagagg ctgtggtgct gagttagact ccaggtactt     3594

tgtggtcaaa ggaaatcgcc tagctccagg ctgtgttagg acagtattag catgaaggct     3654

gtgcgaccat catgcctgct gatccttgag gcaggcctgg tccagaaaac tctgggtcag     3714

tgactgcgca gggccagccg ctaccaggac ggccctgaaa caggacacat ctgttttttg     3774

tccctcaccc tgggcaggcc gcgtcacaat cacagtcctc ctcctcccca ccctgacgtc     3834

tgagcgcagg gcttgaattg ttagtcccaa ctctggccaa agatactttt ttccagagac     3894

agaggccagg aggcagtgag gggagccccg cggggaggcg gcggcgactg ccacagccct     3954

tccagcctgt cttgctggcc gccctggttc atatttgagt ttaattgtac tgaccctgga     4014

cccagataag cagcaacttt gtgtctttgg ggtcacagaa cattttgggg cagtttaatg     4074

tggtaccaaa ctgaaaatag gagctattta tagatggagc agcacttagt gcttcataga     4134

aagcaatgcc tatttttaaa gttacaaacg cagatatcta catagatatg ctttgctgag     4194

aagttaggtc tgtggtagac cagaaaccac aaattgactt tttttcttag aaaatatttc     4254

tatttgcggt aaatatagta atatgtaaat aatgtacatc tgttgatttc tggagtgtct     4314

gttattcaat gatgtatata ctcccacagc tcgcatgaag gaacagcctc tattgatact     4374

tggttgtaaa gtgaagtaag attggagggt ggatggctgt cagagctctt gcagatactg     4434

tgttcactaa ataaaaatca catgtattgt taaaaaaaaa aaaaaaaa                  4482


<210>  88
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Asp Glu Asp Gly Gly Gly Glu Gly Gly Gly Val Pro Glu Asp Leu 
1               5                   10                  15      


Ser Leu Glu Glu Arg Glu Glu Leu Leu Asp Ile Arg Arg Arg Lys Lys 
            20                  25                  30          


Glu Leu Ile Asp Asp Ile Glu Arg Leu Lys Tyr Glu Ile Ala Glu Val 
        35                  40                  45              


Met Thr Glu Ile Asp Asn Leu Thr Ser Val Glu Glu Ser Lys Thr Thr 
    50                  55                  60                  


Gln Arg Asn Lys Gln Ile Ala Met Gly Arg Lys Lys Phe Asn Met Asp 
65                  70                  75                  80  


Pro Lys Lys Gly Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Gln Ser 
                85                  90                  95      


Ser Pro Glu Asp Val Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu Asn 
            100                 105                 110         


Lys Thr Val Ile Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn Ile 
        115                 120                 125             


Lys Val Leu Gln Ala Phe Val Glu Leu His Glu Phe Ala Asp Leu Asn 
    130                 135                 140                 


Leu Val Gln Ala Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly 
145                 150                 155                 160 


Glu Ala Gln Lys Ile Asp Arg Met Met Glu Ala Phe Ala Ser Arg Tyr 
                165                 170                 175     


Cys Leu Cys Asn Pro Gly Val Phe Gln Ser Thr Asp Thr Cys Tyr Val 
            180                 185                 190         


Leu Ser Phe Ala Ile Ile Met Leu Asn Thr Ser Leu His Asn His Asn 
        195                 200                 205             


Val Arg Asp Lys Pro Thr Ala Glu Arg Phe Ile Ala Met Asn Arg Gly 
    210                 215                 220                 


Ile Asn Glu Gly Gly Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr 
225                 230                 235                 240 


Glu Ser Ile Lys Asn Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn 
                245                 250                 255     


Asp Leu Thr His Thr Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu 
            260                 265                 270         


Lys Leu Gly Gly Arg Val Lys Thr Trp Lys Arg Arg Trp Phe Ile Leu 
        275                 280                 285             


Thr Asp Asn Cys Leu Tyr Tyr Phe Glu Tyr Thr Thr Asp Lys Glu Pro 
    290                 295                 300                 


Arg Gly Ile Ile Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Glu Asp 
305                 310                 315                 320 


Pro Arg Lys Pro Asn Cys Phe Glu Leu Tyr Asn Pro Ser His Lys Gly 
                325                 330                 335     


Gln Val Ile Lys Ala Cys Lys Thr Glu Ala Asp Gly Arg Val Val Glu 
            340                 345                 350         


Gly Asn His Val Val Tyr Arg Ile Ser Ala Pro Ser Pro Glu Glu Lys 
        355                 360                 365             


Glu Glu Trp Met Lys Ser Ile Lys Ala Ser Ile Ser Arg Asp Pro Phe 
    370                 375                 380                 


Tyr Asp Met Leu Ala Thr Arg Lys Arg Arg Ile Ala Asn Lys Lys 
385                 390                 395                 


<210>  89
<211>  10835
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (364)..(5436)

<400>  89
gcagaacttt ggcgggcaag gagacaaaca gccacactgt gctgccgggg aagagaagaa       60

gaaggaaagg ccagacacac aggcgtcgtg cagctgcgga aggattccgt ttcctgcagg      120

gggcggaggg atttgacagc acggtaactt ccggaaaagt cctgaacctc agtggaaaag      180

ccttgcaaga aacaataaca aacgggagga ggaagcgatt ctggggtttc tgtgttgaac      240

ggttcttgtc cgcgaagatg cgcttcggcc tctgtcaggg gacttgaacg ggcttagtgg      300

gcttcagcca gcttttctcc accggttccc cacggggacc cccccccccc cccggccgtt      360

gca atg gcg ggc gtg ggg ccg ggg ggc tac gcg gcg gag ttc gtg cca        408
    Met Ala Gly Val Gly Pro Gly Gly Tyr Ala Ala Glu Phe Val Pro           
    1               5                   10                  15            

ccg cca gag tgc ccc gtc ttt gag ccg agt tgg gag gag ttc aca gat        456
Pro Pro Glu Cys Pro Val Phe Glu Pro Ser Trp Glu Glu Phe Thr Asp           
                20                  25                  30                

ccg ctc agc ttt atc ggc cgc atc cgg cct ttg gcg gag aaa acc ggc        504
Pro Leu Ser Phe Ile Gly Arg Ile Arg Pro Leu Ala Glu Lys Thr Gly           
            35                  40                  45                    

atc tgc aaa att cgg ccg ccc aag gac tgg cag cct cca ttt gcc tgt        552
Ile Cys Lys Ile Arg Pro Pro Lys Asp Trp Gln Pro Pro Phe Ala Cys           
        50                  55                  60                        

gaa gta aaa agc ttt cgt ttc act cca aga gtc cag cgc ctg aat gaa        600
Glu Val Lys Ser Phe Arg Phe Thr Pro Arg Val Gln Arg Leu Asn Glu           
    65                  70                  75                            

ctt gag gca atg acc aga gtg aga ttg gat ttc ttg gat caa cta gca        648
Leu Glu Ala Met Thr Arg Val Arg Leu Asp Phe Leu Asp Gln Leu Ala           
80                  85                  90                  95            

aaa ttt tgg gaa ctt caa gga tct act ctg aag atc cct gtg gta gag        696
Lys Phe Trp Glu Leu Gln Gly Ser Thr Leu Lys Ile Pro Val Val Glu           
                100                 105                 110               

aga aaa atc ctg gat ctg tat gct ttg agc aag att gtt gcc agc aaa        744
Arg Lys Ile Leu Asp Leu Tyr Ala Leu Ser Lys Ile Val Ala Ser Lys           
            115                 120                 125                   

gga ggt ttt gaa atg gtc acc aaa gag aag aaa tgg tct aaa gtg ggt        792
Gly Gly Phe Glu Met Val Thr Lys Glu Lys Lys Trp Ser Lys Val Gly           
        130                 135                 140                       

agt cgc ttg gga tat ctg cca gga aaa gga act ggg tct ctt ttg aag        840
Ser Arg Leu Gly Tyr Leu Pro Gly Lys Gly Thr Gly Ser Leu Leu Lys           
    145                 150                 155                           

tca cat tat gaa aga att ctc tac cca tat gag ctt ttc cag tct ggt        888
Ser His Tyr Glu Arg Ile Leu Tyr Pro Tyr Glu Leu Phe Gln Ser Gly           
160                 165                 170                 175           

gtg agc ctt atg ggt gtg cag atg cct aat tta gat ctt aaa gaa aaa        936
Val Ser Leu Met Gly Val Gln Met Pro Asn Leu Asp Leu Lys Glu Lys           
                180                 185                 190               

gtg gag cct gag gtt ctc agc act gat acc caa act tcc cca gag cca        984
Val Glu Pro Glu Val Leu Ser Thr Asp Thr Gln Thr Ser Pro Glu Pro           
            195                 200                 205                   

ggc aca agg atg aac att ctg ccg aag aga aca aga cgt gtg aag act       1032
Gly Thr Arg Met Asn Ile Leu Pro Lys Arg Thr Arg Arg Val Lys Thr           
        210                 215                 220                       

cag tca gaa tct gga gat gtg agt aga aac acg gaa ctg aag aaa ctt       1080
Gln Ser Glu Ser Gly Asp Val Ser Arg Asn Thr Glu Leu Lys Lys Leu           
    225                 230                 235                           

cag att ttt ggg gct ggg ccc aag gtt gtg ggc ttg gca atg gga aca       1128
Gln Ile Phe Gly Ala Gly Pro Lys Val Val Gly Leu Ala Met Gly Thr           
240                 245                 250                 255           

aaa gat aaa gaa gat gag gtc acc cga aga cga aaa gtt acc aac agg       1176
Lys Asp Lys Glu Asp Glu Val Thr Arg Arg Arg Lys Val Thr Asn Arg           
                260                 265                 270               

tca gac gca ttt aac atg caa atg aga caa cgg aaa ggc act ctc tct       1224
Ser Asp Ala Phe Asn Met Gln Met Arg Gln Arg Lys Gly Thr Leu Ser           
            275                 280                 285                   

gtt aac ttt gtt gat ctc tat gtt tgt atg ttt tgt ggt cgg gga aac       1272
Val Asn Phe Val Asp Leu Tyr Val Cys Met Phe Cys Gly Arg Gly Asn           
        290                 295                 300                       

aat gaa gat aaa ttg ctt ttg tgt gat gga tgt gat gac agc tat cat       1320
Asn Glu Asp Lys Leu Leu Leu Cys Asp Gly Cys Asp Asp Ser Tyr His           
    305                 310                 315                           

aca ttt tgt cta att cct cca cta cct gat gtg ccc aaa gga gac tgg       1368
Thr Phe Cys Leu Ile Pro Pro Leu Pro Asp Val Pro Lys Gly Asp Trp           
320                 325                 330                 335           

agg tgt cct aaa tgt gtc gcc gag gaa tgt agc aaa cct cga gaa gcc       1416
Arg Cys Pro Lys Cys Val Ala Glu Glu Cys Ser Lys Pro Arg Glu Ala           
                340                 345                 350               

ttt gga ttt gaa caa gct gta cga gag tat aca ctt cag agc ttt gga       1464
Phe Gly Phe Glu Gln Ala Val Arg Glu Tyr Thr Leu Gln Ser Phe Gly           
            355                 360                 365                   

gag atg gca gat aat ttt aag tct gat tat ttt aat atg cca gtc cat       1512
Glu Met Ala Asp Asn Phe Lys Ser Asp Tyr Phe Asn Met Pro Val His           
        370                 375                 380                       

atg gtt ccc aca gaa cta gta gaa aag gaa ttt tgg cgg ctg gta agc       1560
Met Val Pro Thr Glu Leu Val Glu Lys Glu Phe Trp Arg Leu Val Ser           
    385                 390                 395                           

agc att gaa gaa gat gtt att gtg gaa tat gga gca gat atc tcc tca       1608
Ser Ile Glu Glu Asp Val Ile Val Glu Tyr Gly Ala Asp Ile Ser Ser           
400                 405                 410                 415           

aaa gac ttt gga agt gga ttt ccg gtg aag gat ggg cgg aga aag att       1656
Lys Asp Phe Gly Ser Gly Phe Pro Val Lys Asp Gly Arg Arg Lys Ile           
                420                 425                 430               

ctg cca gaa gaa gag gaa tat gca ctt tct ggt tgg aat ttg aat aac       1704
Leu Pro Glu Glu Glu Glu Tyr Ala Leu Ser Gly Trp Asn Leu Asn Asn           
            435                 440                 445                   

atg cct gtc ctg gaa cag tct gtt ctt gca cat att aat gtg gac atc       1752
Met Pro Val Leu Glu Gln Ser Val Leu Ala His Ile Asn Val Asp Ile           
        450                 455                 460                       

tct ggt atg aaa gtg ccg tgg ctc tat gtg gga atg tgc ttc tct tct       1800
Ser Gly Met Lys Val Pro Trp Leu Tyr Val Gly Met Cys Phe Ser Ser           
    465                 470                 475                           

ttt tgc tgg cac att gag gat cac tgg agt tat tcc atc aac tac ttg       1848
Phe Cys Trp His Ile Glu Asp His Trp Ser Tyr Ser Ile Asn Tyr Leu           
480                 485                 490                 495           

cac tgg ggg gag cca aag aca tgg tat ggt gtg cca tct cat gct gca       1896
His Trp Gly Glu Pro Lys Thr Trp Tyr Gly Val Pro Ser His Ala Ala           
                500                 505                 510               

gag caa ctg gag gag gtg atg aga gag ctg gcc ccc gag tta ttt gaa       1944
Glu Gln Leu Glu Glu Val Met Arg Glu Leu Ala Pro Glu Leu Phe Glu           
            515                 520                 525                   

tcc cag cct gat ctt ctg cat cag tta gtt acc atc atg aac ccc aac       1992
Ser Gln Pro Asp Leu Leu His Gln Leu Val Thr Ile Met Asn Pro Asn           
        530                 535                 540                       

gtg cta atg gag cat ggt gtg cct gtg tac agg acc aat cag tgt gct       2040
Val Leu Met Glu His Gly Val Pro Val Tyr Arg Thr Asn Gln Cys Ala           
    545                 550                 555                           

ggc gag ttt gtt gtg aca ttt cct cgt gcc tat cac tct gga ttt aac       2088
Gly Glu Phe Val Val Thr Phe Pro Arg Ala Tyr His Ser Gly Phe Asn           
560                 565                 570                 575           

cag ggc tac aac ttt gct gaa gct gtg aac ttc tgt act gct gac tgg       2136
Gln Gly Tyr Asn Phe Ala Glu Ala Val Asn Phe Cys Thr Ala Asp Trp           
                580                 585                 590               

ttg ccc att gga cgt caa tgt gta aat cat tac cga cgc cta agg cgc       2184
Leu Pro Ile Gly Arg Gln Cys Val Asn His Tyr Arg Arg Leu Arg Arg           
            595                 600                 605                   

cac tgt gtc ttt tca cac gag gaa cta att ttc aag atg gca gca gat       2232
His Cys Val Phe Ser His Glu Glu Leu Ile Phe Lys Met Ala Ala Asp           
        610                 615                 620                       

cca gaa tgc tta gat gtg ggg ctg gct gcc atg gtc tgc aaa gaa ttg       2280
Pro Glu Cys Leu Asp Val Gly Leu Ala Ala Met Val Cys Lys Glu Leu           
    625                 630                 635                           

act ctc atg act gaa gaa gaa aca cga tta aga gag tct gtt gta cag       2328
Thr Leu Met Thr Glu Glu Glu Thr Arg Leu Arg Glu Ser Val Val Gln           
640                 645                 650                 655           

atg ggt gtc ctg atg tca gaa gaa gaa gtg ttt gaa ctt gtt cct gat       2376
Met Gly Val Leu Met Ser Glu Glu Glu Val Phe Glu Leu Val Pro Asp           
                660                 665                 670               

gat gag cgg cag tgt tca gca tgc aga acc aca tgt ttt ctc tct gct       2424
Asp Glu Arg Gln Cys Ser Ala Cys Arg Thr Thr Cys Phe Leu Ser Ala           
            675                 680                 685                   

ctc aca tgt tcc tgt aat cct gag cgg ctt gta tgt ctc tac cat cca       2472
Leu Thr Cys Ser Cys Asn Pro Glu Arg Leu Val Cys Leu Tyr His Pro           
        690                 695                 700                       

act gat ctg tgc ccc tgc ccc atg cag aag aaa tgt ctt aga tat cgc       2520
Thr Asp Leu Cys Pro Cys Pro Met Gln Lys Lys Cys Leu Arg Tyr Arg           
    705                 710                 715                           

tac cca tta gaa gac ctc cct tct ctg cta tat ggt gta aaa gtc agg       2568
Tyr Pro Leu Glu Asp Leu Pro Ser Leu Leu Tyr Gly Val Lys Val Arg           
720                 725                 730                 735           

gca cag tcc tat gac act tgg gtc agt cgt gtt aca gaa gca ttg tct       2616
Ala Gln Ser Tyr Asp Thr Trp Val Ser Arg Val Thr Glu Ala Leu Ser           
                740                 745                 750               

gct aac ttc aac cac aaa aaa gat ttg att gaa ttg cga gta atg ctg       2664
Ala Asn Phe Asn His Lys Lys Asp Leu Ile Glu Leu Arg Val Met Leu           
            755                 760                 765                   

gaa gat gct gag gat agg aaa tac cca gag aat gat ctc ttt cga aaa       2712
Glu Asp Ala Glu Asp Arg Lys Tyr Pro Glu Asn Asp Leu Phe Arg Lys           
        770                 775                 780                       

ctc agg gat gct gta aaa gaa gct gag acc tgt gct tct gtg gct cag       2760
Leu Arg Asp Ala Val Lys Glu Ala Glu Thr Cys Ala Ser Val Ala Gln           
    785                 790                 795                           

ctg ctt ctg agc aaa aag cag aaa cac aga cag agc cca gat agt ggg       2808
Leu Leu Leu Ser Lys Lys Gln Lys His Arg Gln Ser Pro Asp Ser Gly           
800                 805                 810                 815           

agg act cgg acc aaa ctg aca gtg gaa gaa ttg aag gcc ttt gtc caa       2856
Arg Thr Arg Thr Lys Leu Thr Val Glu Glu Leu Lys Ala Phe Val Gln           
                820                 825                 830               

caa ctt ttt agt ctt ccg tgt gtc atc agc caa gct cgg caa gta aag       2904
Gln Leu Phe Ser Leu Pro Cys Val Ile Ser Gln Ala Arg Gln Val Lys           
            835                 840                 845                   

aat ctg cta gat gat gtg gaa gag ttt cat gaa cgt gct cag gag gcc       2952
Asn Leu Leu Asp Asp Val Glu Glu Phe His Glu Arg Ala Gln Glu Ala           
        850                 855                 860                       

atg atg gat gaa acc cca gat tct tcc aaa ctc cag atg ttg ata gat       3000
Met Met Asp Glu Thr Pro Asp Ser Ser Lys Leu Gln Met Leu Ile Asp           
    865                 870                 875                           

atg ggc tct agt ctc tat gtg gaa ctc cct gaa tta cca cga ctg aag       3048
Met Gly Ser Ser Leu Tyr Val Glu Leu Pro Glu Leu Pro Arg Leu Lys           
880                 885                 890                 895           

caa gag cta caa cag gct cgg tgg ttg gac gaa gta aga ctg acc tta       3096
Gln Glu Leu Gln Gln Ala Arg Trp Leu Asp Glu Val Arg Leu Thr Leu           
                900                 905                 910               

tca gat ccg caa caa gtc act ttg gat gtc atg aag aag ctg ata gac       3144
Ser Asp Pro Gln Gln Val Thr Leu Asp Val Met Lys Lys Leu Ile Asp           
            915                 920                 925                   

tct ggg gta ggg ttg gca ccc cac cat gct gtg gag aaa gca atg gct       3192
Ser Gly Val Gly Leu Ala Pro His His Ala Val Glu Lys Ala Met Ala           
        930                 935                 940                       

gaa cta cag gag ctc ctt aca gtc tct gaa cga tgg gaa gaa aag gct       3240
Glu Leu Gln Glu Leu Leu Thr Val Ser Glu Arg Trp Glu Glu Lys Ala           
    945                 950                 955                           

aag gtc tgc cta cag gca aga ccg agg cac agt gtg gca agt tta gaa       3288
Lys Val Cys Leu Gln Ala Arg Pro Arg His Ser Val Ala Ser Leu Glu           
960                 965                 970                 975           

agc att gtg aat gaa gcc aag aac att cca gcc ttt cta ccc aat gtg       3336
Ser Ile Val Asn Glu Ala Lys Asn Ile Pro Ala Phe Leu Pro Asn Val           
                980                 985                 990               

ttg tcc ttg aaa gaa gcc tta caa aag  gct cga gaa tgg acc  gct aaa     3384
Leu Ser Leu Lys Glu Ala Leu Gln Lys  Ala Arg Glu Trp Thr  Ala Lys         
            995                 1000                 1005                 

gtg gaa gct  att cag agt ggc agc  aat tac gct tat ttg  gag cag        3429
Val Glu Ala  Ile Gln Ser Gly Ser  Asn Tyr Ala Tyr Leu  Glu Gln            
        1010                 1015                 1020                    

ctt gag agc  ttg tct gcg aaa gga  cgc cct att cct gtg  cgt ctt        3474
Leu Glu Ser  Leu Ser Ala Lys Gly  Arg Pro Ile Pro Val  Arg Leu            
        1025                 1030                 1035                    

gaa gca ctg  ccg caa gtg gaa tca  cag gta gca gca gca  cgg gca        3519
Glu Ala Leu  Pro Gln Val Glu Ser  Gln Val Ala Ala Ala  Arg Ala            
        1040                 1045                 1050                    

tgg aga gaa  cgg act ggg cgg acg  ttt ctt aag aag aat  tct agc        3564
Trp Arg Glu  Arg Thr Gly Arg Thr  Phe Leu Lys Lys Asn  Ser Ser            
        1055                 1060                 1065                    

cat aca ttg  tta cag gtg ctg agc  ccc cgg acc gac att  ggt gta        3609
His Thr Leu  Leu Gln Val Leu Ser  Pro Arg Thr Asp Ile  Gly Val            
        1070                 1075                 1080                    

tat ggg agt  ggc aaa aat agg agg  aaa aaa gta aaa gaa  cta ata        3654
Tyr Gly Ser  Gly Lys Asn Arg Arg  Lys Lys Val Lys Glu  Leu Ile            
        1085                 1090                 1095                    

gaa aaa gaa  aaa gaa aag gat ctg  gac ctg gag cct ctg  agt gat        3699
Glu Lys Glu  Lys Glu Lys Asp Leu  Asp Leu Glu Pro Leu  Ser Asp            
        1100                 1105                 1110                    

ctg gag gaa  gga ttg gag gaa acc  aga gat aca gcc atg  gtg gtg        3744
Leu Glu Glu  Gly Leu Glu Glu Thr  Arg Asp Thr Ala Met  Val Val            
        1115                 1120                 1125                    

gca gtt ttc  aaa gaa cgg gag caa  aaa gag att gaa gcc  atg cat        3789
Ala Val Phe  Lys Glu Arg Glu Gln  Lys Glu Ile Glu Ala  Met His            
        1130                 1135                 1140                    

tct ctc aga  gca gcc aac cta gcc  aag atg aca atg gtg  gac cgc        3834
Ser Leu Arg  Ala Ala Asn Leu Ala  Lys Met Thr Met Val  Asp Arg            
        1145                 1150                 1155                    

ata gaa gaa  gta aaa ttt tgc att  tgc cgc aag aca gcc  agt ggg        3879
Ile Glu Glu  Val Lys Phe Cys Ile  Cys Arg Lys Thr Ala  Ser Gly            
        1160                 1165                 1170                    

ttt atg cta  cag tgt gag ctc tgc  aaa gac tgg ttc cat  aac agc        3924
Phe Met Leu  Gln Cys Glu Leu Cys  Lys Asp Trp Phe His  Asn Ser            
        1175                 1180                 1185                    

tgt gtt cct  ctt cct aaa tca agt  tcc caa aaa aaa gga  tcc agc        3969
Cys Val Pro  Leu Pro Lys Ser Ser  Ser Gln Lys Lys Gly  Ser Ser            
        1190                 1195                 1200                    

tgg caa gct  aaa gaa gta aaa ttc  ctt tgc cct ctt tgt  atg cgg        4014
Trp Gln Ala  Lys Glu Val Lys Phe  Leu Cys Pro Leu Cys  Met Arg            
        1205                 1210                 1215                    

tct cga agg  ccc agg cta gag act  att ctg tca ctc ctg  gta tcc        4059
Ser Arg Arg  Pro Arg Leu Glu Thr  Ile Leu Ser Leu Leu  Val Ser            
        1220                 1225                 1230                    

ctt cag aag  ttg ccc gta cgg ttg  cct gaa gga gag gcc  ctg cag        4104
Leu Gln Lys  Leu Pro Val Arg Leu  Pro Glu Gly Glu Ala  Leu Gln            
        1235                 1240                 1245                    

tgt ttg aca  gaa cgt gct atg agt  tgg caa gat aga gcg  cgg cag        4149
Cys Leu Thr  Glu Arg Ala Met Ser  Trp Gln Asp Arg Ala  Arg Gln            
        1250                 1255                 1260                    

gct cta gcc  aca gat gaa cta tcc  tct gcc ctg gcc aaa  cta tct        4194
Ala Leu Ala  Thr Asp Glu Leu Ser  Ser Ala Leu Ala Lys  Leu Ser            
        1265                 1270                 1275                    

gtg ttg agc  cag cgt atg gtg gaa  cag gcg gct cga gaa  aaa act        4239
Val Leu Ser  Gln Arg Met Val Glu  Gln Ala Ala Arg Glu  Lys Thr            
        1280                 1285                 1290                    

gaa aag atc  atc agt gca gaa ctc  caa aaa gca gct gcc  aat cca        4284
Glu Lys Ile  Ile Ser Ala Glu Leu  Gln Lys Ala Ala Ala  Asn Pro            
        1295                 1300                 1305                    

gac tta cag  gga cac tta cct agt  ttc cag cag tct gct  ttt aac        4329
Asp Leu Gln  Gly His Leu Pro Ser  Phe Gln Gln Ser Ala  Phe Asn            
        1310                 1315                 1320                    

cgg gtg gtg  agc agt gtg tca tct  tct cct cga caa aca  atg gac        4374
Arg Val Val  Ser Ser Val Ser Ser  Ser Pro Arg Gln Thr  Met Asp            
        1325                 1330                 1335                    

tat gat gat  gaa gaa aca gac tct  gat gaa gac att cga  gag aca        4419
Tyr Asp Asp  Glu Glu Thr Asp Ser  Asp Glu Asp Ile Arg  Glu Thr            
        1340                 1345                 1350                    

tat ggc tac  gac atg aag gac aca  gcc agt gtg aag tcc  tct agt        4464
Tyr Gly Tyr  Asp Met Lys Asp Thr  Ala Ser Val Lys Ser  Ser Ser            
        1355                 1360                 1365                    

agt ctt gaa  ccc aat ctt ttt tgt  gat gaa gag att ccc  atc aaa        4509
Ser Leu Glu  Pro Asn Leu Phe Cys  Asp Glu Glu Ile Pro  Ile Lys            
        1370                 1375                 1380                    

tcc gag gag  gtg gtg acc cac atg  tgg aca gca cct tca  ttt tgt        4554
Ser Glu Glu  Val Val Thr His Met  Trp Thr Ala Pro Ser  Phe Cys            
        1385                 1390                 1395                    

gca gag cat  gct tat tct tct gct  tct aag agt tgt tct  caa ggt        4599
Ala Glu His  Ala Tyr Ser Ser Ala  Ser Lys Ser Cys Ser  Gln Gly            
        1400                 1405                 1410                    

tct agc acc  cca agg aaa caa cct  cgg aag agc cct ttg  gtg ccc        4644
Ser Ser Thr  Pro Arg Lys Gln Pro  Arg Lys Ser Pro Leu  Val Pro            
        1415                 1420                 1425                    

cga agt ttg  gaa cct cca gtg ctg  gag ttg tca cct gga  gct aag        4689
Arg Ser Leu  Glu Pro Pro Val Leu  Glu Leu Ser Pro Gly  Ala Lys            
        1430                 1435                 1440                    

gca caa ctg  gaa gaa ctt atg atg  gtt gga gat ctc ctg  gaa gta        4734
Ala Gln Leu  Glu Glu Leu Met Met  Val Gly Asp Leu Leu  Glu Val            
        1445                 1450                 1455                    

tct ctg gac  gag act caa cac ata  tgg cgg att ttg cag  gcc aca        4779
Ser Leu Asp  Glu Thr Gln His Ile  Trp Arg Ile Leu Gln  Ala Thr            
        1460                 1465                 1470                    

cac cca ccc  tct gaa gac aga ttc  ttg cat atc atg gag  gat gac        4824
His Pro Pro  Ser Glu Asp Arg Phe  Leu His Ile Met Glu  Asp Asp            
        1475                 1480                 1485                    

agc atg gaa  gag aaa cca cta aaa  gtg aaa gga aag gac  tct tca        4869
Ser Met Glu  Glu Lys Pro Leu Lys  Val Lys Gly Lys Asp  Ser Ser            
        1490                 1495                 1500                    

gag aag aaa  cgg aaa cgg aag cta  gaa aag gta gag caa  ctt ttt        4914
Glu Lys Lys  Arg Lys Arg Lys Leu  Glu Lys Val Glu Gln  Leu Phe            
        1505                 1510                 1515                    

gga gaa gga  aaa cag aag tcc aag  gag tta aag aaa atg  gac aaa        4959
Gly Glu Gly  Lys Gln Lys Ser Lys  Glu Leu Lys Lys Met  Asp Lys            
        1520                 1525                 1530                    

cct aga aag  aag aaa tta aaa tta  ggt gca gac aaa tca  aag gag        5004
Pro Arg Lys  Lys Lys Leu Lys Leu  Gly Ala Asp Lys Ser  Lys Glu            
        1535                 1540                 1545                    

ctg aat aaa  ctg gcc aag aaa cta  gca aaa gaa gaa gag  aga aag        5049
Leu Asn Lys  Leu Ala Lys Lys Leu  Ala Lys Glu Glu Glu  Arg Lys            
        1550                 1555                 1560                    

aaa aag aag  gag aag gct gct gca  gcc aaa gtt gaa ctt  gtg aaa        5094
Lys Lys Lys  Glu Lys Ala Ala Ala  Ala Lys Val Glu Leu  Val Lys            
        1565                 1570                 1575                    

gag agc act  gaa aag aaa aga gag  aaa aag gtg ctg gac  atc ccc        5139
Glu Ser Thr  Glu Lys Lys Arg Glu  Lys Lys Val Leu Asp  Ile Pro            
        1580                 1585                 1590                    

tca aag tat  gac tgg tca gga gca  gag gag tct gat gat  gag aat        5184
Ser Lys Tyr  Asp Trp Ser Gly Ala  Glu Glu Ser Asp Asp  Glu Asn            
        1595                 1600                 1605                    

gct gtg tgc  gca gca cag aac tgc  caa agg ccc tgc aag  gac aag        5229
Ala Val Cys  Ala Ala Gln Asn Cys  Gln Arg Pro Cys Lys  Asp Lys            
        1610                 1615                 1620                    

gta gac tgg  gta caa tgt gat ggt  ggc tgt gat gag tgg  ttt cat        5274
Val Asp Trp  Val Gln Cys Asp Gly  Gly Cys Asp Glu Trp  Phe His            
        1625                 1630                 1635                    

caa gtt tgt  gtg ggt gta tct cca  gaa atg gct gaa aat  gaa gat        5319
Gln Val Cys  Val Gly Val Ser Pro  Glu Met Ala Glu Asn  Glu Asp            
        1640                 1645                 1650                    

tac atc tgt  ata aac tgt gca aag  aag cag ggg cca gtt  agc cca        5364
Tyr Ile Cys  Ile Asn Cys Ala Lys  Lys Gln Gly Pro Val  Ser Pro            
        1655                 1660                 1665                    

ggt cca gca  cca cct cct tcc ttc  ata atg agc tac aaa  cta cca        5409
Gly Pro Ala  Pro Pro Pro Ser Phe  Ile Met Ser Tyr Lys  Leu Pro            
        1670                 1675                 1680                    

atg gag gat  ctt aaa gag acc agt  tag cagatgcttg gttagtttgg           5456
Met Glu Asp  Leu Lys Glu Thr Ser                                          
        1685                 1690                                         

gacatggggg gacatggacc acattgagac cttagtcatc aagtagagtg gtttatatcc     5516

acttggaatg ttgcttccaa agatgaatgg ccttcagaga aagtcccctt agtgctggct     5576

tcctctttgc atggactctg tgggttacat tctctatcaa catatctatg cagagggtgt     5636

cttctttggt acaacagcca atatttcatg tctcctttga gtgtggttta ctgcattaag     5696

gccagatgct taattgagct ctagggtggc tggttagtat taatacattg gtgtgctaac     5756

agggcatata ggatgtggct tttgtccagc tgatagtagt tagaggctta caacttagga     5816

gcagcaccaa ctgaaggtgc taattgcttg gatctccttc attgggatag ttggagaggg     5876

attggagtac cactttcctt ccactgttac ctggtactta atgccctaaa gatacaacta     5936

ggagtaacag ggccaaagtt atttctgtta gacgtcaagg aatggtatca cagtctattg     5996

acctcagcga tttgtgcttg tttgtgctag aagaacatcc caaataggag aacctctcac     6056

aagctggggc aggtcacctt atctttgtaa gatgaggata tcatctagat cagaaatctg     6116

actagattgg attctgagga gaagaaccta ctacaaggca aggagccgtt ttttggcttt     6176

gaaaagtctt gctgtcttgg gtctacattt tagggaagag caggtacatg gatccaggct     6236

tctgccaaaa aaaaaaagag aagaagatga cgatgatgac cagtcgtact atcttactga     6296

gccacagtga tgcatgcttt tcggggaaaa cttcattcac aagtattcca gacaccaggc     6356

ttcaggcatg gccatgagca agaccagcaa ataacagctt tttgccttgc agccctgacc     6416

ccaatgtctg ctgtttccaa cactggtgat ttctaactac ggcccacagc agatgctgtt     6476

gaataacacc atggcttcat cagaggatgt ggggttgtag tacctctggg tgatgaagtt     6536

gttttagtaa atccattttt aaaaaaaaaa aaggacttgt ttttactttt ttctaaatgt     6596

ctctgactac tgactgttct atacatagat tatttttcct tttttaatat acatatatga     6656

atatataaat atatatattt actgttacca gcagcatatg acagagtttc aacatcaaaa     6716

atccatttgg gggcttgctt tttctttttt gctttaaaaa aaaaaatccc attccttctt     6776

tgtagtacaa ggagttagca ctccctcctc catcccagcc tgaccagatc ttccattttg     6836

cttttgttca tatagataat tatatgtcct ttgtgtgttg ggacttgtcc ctgtctgttg     6896

ggaaacttgg tctcactcta gtctgtgctg gctctttttt cttttgtgtg tgaatgtttg     6956

aaactatggt gctgtgtcct cttccctcct gttgtgttct ctgttcttct taaggtatta     7016

ggtaagctgt atgtaaactc ttattagaag gggactaatt tttttttaaa ggacaaaaaa     7076

aaaaatgact aaaaatagtg ttttgtcatc actgtctggt gtctttattt tggtttaaaa     7136

aaatctgtgg tttgacttaa attcatcagt tttcctttta aaggggggat tggggtggac     7196

ctagcaacag cttatagttt cctcttccct ttttgcccca gtctctttta aagaactgtc     7256

ttctagtaac tagaagtgaa atgtactgtc cagttacagt ttgagtgggt atgagattta     7316

actcaaaagg aatcttacaa aaaaaaagat gttttcttat aaaatccaat ttctgtaaat     7376

gttttctctg aagttcatac tacctacttt ttattcattc ttaatactgt ataacatttt     7436

gagtgttttg acttgttcag aggtttgtta gtgttgctgt gcatatgtct tgaggtctca     7496

tctgaagtaa gtttgtgtat gatcgaagat ttcaatggat attgcaaggt aactaattaa     7556

ctgatttcat aagttttcgt tttgccaagc taacgattat caattaagaa tttcctctgg     7616

ttgatgttat acaagaaagc acaatatttt ttgcctgttg atcttctttg taacagtctt     7676

cagatatttg tgggttaaaa attgaatgta attttaagtg acagatgcct ggaatacatt     7736

taaaattttt atttttcctt cctaatcatc cattaactat tccactatca gtggagagtc     7796

atgaggatgc tgagaaagta tgaatagctt cctgtcacct tctgacgttt tgaaacttaa     7856

atatgtcttt tcgttgatac tgtgggattt tctgtattta cttgacagtc atggaggatt     7916

tggtatgact tgaccacagg tttagaccaa ggctgagaag aacagaaggg agaaattaat     7976

ggcaaaacaa aaaatacaca aatctgcggt tttggaatta atgaaacaag attcatctat     8036

ttaaagaaat gttggtgttc taatacaaag cattattttc acttagagaa aattacttac     8096

ttgctccctt ctgtattgta atattttgta ttaagacatg atttaaaatg tctttctacc     8156

cttatctcct ctaaactgca actgaagttg caattcttca tcattagtat tttaactctg     8216

gcaaaggtta tagaaagaaa aatggaaata tggtaggcct gtggtattct taaaagctaa     8276

gtcattagaa ctatgcagat ccccaagttt aaaagtacaa atacagcacc agtagttagc     8336

tttctagctg ggggagaaga caggagattt ttcttccaca gatgtttatt ttgcttcctg     8396

ataggtactg cagcaaagcc atgttgatgt gtagatgcat gacttcctca ctaagctgct     8456

gcacaccagc tttgcctgca tgattcaaat ttgtgcctca gtaaaattat aaattattgc     8516

atgtcatacc ttgaataatg gaaacggcaa acattaaacc tgtgattacc cataatgtac     8576

tttaataata aaaaacatgg cagccaggtg cagtagagtg cacctgtggt caggaggctg     8636

aagtgggaag attgcttcaa cctgtgagtt tgagtcccgc ctggtcaaca gcgagacccc     8696

atgtgtctgt ctgtctctct ctttttttaa aggacagagg ctaagctgta aggttagcat     8756

ggttctgcct gggctttgct tctgtgcttc tgtgcaggct gagctgtaag gttagcatgg     8816

ttctgcctgg gctttgcttc tgcgcttctg tgcaggctga gctgtaaggt tagcatggtt     8876

ctgcctgggc tttgcttctg cgcttctgtg caggctgagc tgtaaggtta gcatggttct     8936

gcctgggctt tgcttctgcg cttctgtgct agcaggtgcc cacaaaatgt ctttttgaat     8996

ttcttaattt ttgggttctg gatgcaattc gtgcacgcca agaaactact tgcttgtcag     9056

tattttaatt ctgtagtaca tgtgtgtgaa tatcagccag tacttacagt aggaggatga     9116

acagaaaaac tgagaagacc tgtctttcaa aagatgggtt tatccacttt ttaagggaaa     9176

aagtgacagt ttggcatggg atttgaaaag tggaaattgt ggaaaaattg agctgttgaa     9236

gtcccacata taaccagatt taataaagct tcacatgtga attagctcca tatgtgtgta     9296

gaaggttgct tttatagcag gtccttaagt actccttttg aaattcctcc ttttttttta     9356

agtcatacca ttacttcttt ggatatgaat gtcccaagtg gtatctccta ctgtagtatg     9416

aggaagaatg gctgttaatg tattttttga attttggtct tgtcttggcc tggatcatat     9476

ccagtcacca ctatgcaaca aatgatgtgc actgggcaag gatatgatgg gttatgaaag     9536

ctgtatcttg tttgtttttt cttttgcagt actccaagtg gtctaaacag gaatgtcttg     9596

taaaacctca agactcccta ttgattattc ccttacatat ttatttacaa tttatcaggg     9656

taattggtgg tgccttatga aaagtataac tcgatttctt gatctttgag catgttttgt     9716

gtttcttgtg ttttctaaaa gaatattaga tatggttaat tgcattacat ctaaaagatt     9776

taaaaaattg tgtgtatgct caggttcccc acacccatac ccaccctaac ccctgtcatt     9836

tacattggtg gcaactttaa atggtaacca agcaaaagta cattttgata atgagtattg     9896

ataatcctga ggaaaactag tgagtatatg ggagccacct ttgacctgtg ccaaagcagt     9956

ttctaatttc atttgctaac tataaaataa agaactgagc caaaataatt tgatcagtgg    10016

tgtgattagc ctattatcat tgctgagaat agtgtttttg gagtgtgaag tgattcctga    10076

agatttcacc tgccttctgt ttccagcaag aatccagtga tgaccaacac atttcctcac    10136

ttttggttct tgagaagttt atccctttgc aacaaaccat taatagggaa aacaaggaaa    10196

tgctttccct ttctctttgg cttcttaaag ctcacaacca attcagaccc caagttactt    10256

cagagaagca aatggcacct tttccccatt gccaaggatc ccagcttatg cagatatgaa    10316

ggacggatca tttctgaaaa tgttaagact ctgcttgcag tggacttggc ctcagtttca    10376

tgaaatgtgt aactctgtat gtgtatgtta ggaggagggt tggttgaaag agcgggggca    10436

gggaggggaa tctgattacc tcttgggaaa taattttctt gccaacaaaa agatacactt    10496

gaagtttctt aaggtggcaa gtccattaaa aaaaaaaatt gtgttggacc ctcccagttt    10556

agatcaagta tttcttgggg gtcttgctat tgtggttgat accaataaat ggaagatcca    10616

gaatattttc atttaaagct caaccattaa ttggaacatg gtgaaacatt gtacacattg    10676

taaaagtagg gaacagtaca aaagaatgga atcaaatact atattatgtg aataaactag    10736

agtgattttg gaatttcact ctcttcaccc cttctcactt gtatgttctg taaagtgtat    10796

ttctactttg gtaggaagaa agacttgatt taatatttc                           10835


<210>  90
<211>  1690
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ala Gly Val Gly Pro Gly Gly Tyr Ala Ala Glu Phe Val Pro Pro 
1               5                   10                  15      


Pro Glu Cys Pro Val Phe Glu Pro Ser Trp Glu Glu Phe Thr Asp Pro 
            20                  25                  30          


Leu Ser Phe Ile Gly Arg Ile Arg Pro Leu Ala Glu Lys Thr Gly Ile 
        35                  40                  45              


Cys Lys Ile Arg Pro Pro Lys Asp Trp Gln Pro Pro Phe Ala Cys Glu 
    50                  55                  60                  


Val Lys Ser Phe Arg Phe Thr Pro Arg Val Gln Arg Leu Asn Glu Leu 
65                  70                  75                  80  


Glu Ala Met Thr Arg Val Arg Leu Asp Phe Leu Asp Gln Leu Ala Lys 
                85                  90                  95      


Phe Trp Glu Leu Gln Gly Ser Thr Leu Lys Ile Pro Val Val Glu Arg 
            100                 105                 110         


Lys Ile Leu Asp Leu Tyr Ala Leu Ser Lys Ile Val Ala Ser Lys Gly 
        115                 120                 125             


Gly Phe Glu Met Val Thr Lys Glu Lys Lys Trp Ser Lys Val Gly Ser 
    130                 135                 140                 


Arg Leu Gly Tyr Leu Pro Gly Lys Gly Thr Gly Ser Leu Leu Lys Ser 
145                 150                 155                 160 


His Tyr Glu Arg Ile Leu Tyr Pro Tyr Glu Leu Phe Gln Ser Gly Val 
                165                 170                 175     


Ser Leu Met Gly Val Gln Met Pro Asn Leu Asp Leu Lys Glu Lys Val 
            180                 185                 190         


Glu Pro Glu Val Leu Ser Thr Asp Thr Gln Thr Ser Pro Glu Pro Gly 
        195                 200                 205             


Thr Arg Met Asn Ile Leu Pro Lys Arg Thr Arg Arg Val Lys Thr Gln 
    210                 215                 220                 


Ser Glu Ser Gly Asp Val Ser Arg Asn Thr Glu Leu Lys Lys Leu Gln 
225                 230                 235                 240 


Ile Phe Gly Ala Gly Pro Lys Val Val Gly Leu Ala Met Gly Thr Lys 
                245                 250                 255     


Asp Lys Glu Asp Glu Val Thr Arg Arg Arg Lys Val Thr Asn Arg Ser 
            260                 265                 270         


Asp Ala Phe Asn Met Gln Met Arg Gln Arg Lys Gly Thr Leu Ser Val 
        275                 280                 285             


Asn Phe Val Asp Leu Tyr Val Cys Met Phe Cys Gly Arg Gly Asn Asn 
    290                 295                 300                 


Glu Asp Lys Leu Leu Leu Cys Asp Gly Cys Asp Asp Ser Tyr His Thr 
305                 310                 315                 320 


Phe Cys Leu Ile Pro Pro Leu Pro Asp Val Pro Lys Gly Asp Trp Arg 
                325                 330                 335     


Cys Pro Lys Cys Val Ala Glu Glu Cys Ser Lys Pro Arg Glu Ala Phe 
            340                 345                 350         


Gly Phe Glu Gln Ala Val Arg Glu Tyr Thr Leu Gln Ser Phe Gly Glu 
        355                 360                 365             


Met Ala Asp Asn Phe Lys Ser Asp Tyr Phe Asn Met Pro Val His Met 
    370                 375                 380                 


Val Pro Thr Glu Leu Val Glu Lys Glu Phe Trp Arg Leu Val Ser Ser 
385                 390                 395                 400 


Ile Glu Glu Asp Val Ile Val Glu Tyr Gly Ala Asp Ile Ser Ser Lys 
                405                 410                 415     


Asp Phe Gly Ser Gly Phe Pro Val Lys Asp Gly Arg Arg Lys Ile Leu 
            420                 425                 430         


Pro Glu Glu Glu Glu Tyr Ala Leu Ser Gly Trp Asn Leu Asn Asn Met 
        435                 440                 445             


Pro Val Leu Glu Gln Ser Val Leu Ala His Ile Asn Val Asp Ile Ser 
    450                 455                 460                 


Gly Met Lys Val Pro Trp Leu Tyr Val Gly Met Cys Phe Ser Ser Phe 
465                 470                 475                 480 


Cys Trp His Ile Glu Asp His Trp Ser Tyr Ser Ile Asn Tyr Leu His 
                485                 490                 495     


Trp Gly Glu Pro Lys Thr Trp Tyr Gly Val Pro Ser His Ala Ala Glu 
            500                 505                 510         


Gln Leu Glu Glu Val Met Arg Glu Leu Ala Pro Glu Leu Phe Glu Ser 
        515                 520                 525             


Gln Pro Asp Leu Leu His Gln Leu Val Thr Ile Met Asn Pro Asn Val 
    530                 535                 540                 


Leu Met Glu His Gly Val Pro Val Tyr Arg Thr Asn Gln Cys Ala Gly 
545                 550                 555                 560 


Glu Phe Val Val Thr Phe Pro Arg Ala Tyr His Ser Gly Phe Asn Gln 
                565                 570                 575     


Gly Tyr Asn Phe Ala Glu Ala Val Asn Phe Cys Thr Ala Asp Trp Leu 
            580                 585                 590         


Pro Ile Gly Arg Gln Cys Val Asn His Tyr Arg Arg Leu Arg Arg His 
        595                 600                 605             


Cys Val Phe Ser His Glu Glu Leu Ile Phe Lys Met Ala Ala Asp Pro 
    610                 615                 620                 


Glu Cys Leu Asp Val Gly Leu Ala Ala Met Val Cys Lys Glu Leu Thr 
625                 630                 635                 640 


Leu Met Thr Glu Glu Glu Thr Arg Leu Arg Glu Ser Val Val Gln Met 
                645                 650                 655     


Gly Val Leu Met Ser Glu Glu Glu Val Phe Glu Leu Val Pro Asp Asp 
            660                 665                 670         


Glu Arg Gln Cys Ser Ala Cys Arg Thr Thr Cys Phe Leu Ser Ala Leu 
        675                 680                 685             


Thr Cys Ser Cys Asn Pro Glu Arg Leu Val Cys Leu Tyr His Pro Thr 
    690                 695                 700                 


Asp Leu Cys Pro Cys Pro Met Gln Lys Lys Cys Leu Arg Tyr Arg Tyr 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Pro Ser Leu Leu Tyr Gly Val Lys Val Arg Ala 
                725                 730                 735     


Gln Ser Tyr Asp Thr Trp Val Ser Arg Val Thr Glu Ala Leu Ser Ala 
            740                 745                 750         


Asn Phe Asn His Lys Lys Asp Leu Ile Glu Leu Arg Val Met Leu Glu 
        755                 760                 765             


Asp Ala Glu Asp Arg Lys Tyr Pro Glu Asn Asp Leu Phe Arg Lys Leu 
    770                 775                 780                 


Arg Asp Ala Val Lys Glu Ala Glu Thr Cys Ala Ser Val Ala Gln Leu 
785                 790                 795                 800 


Leu Leu Ser Lys Lys Gln Lys His Arg Gln Ser Pro Asp Ser Gly Arg 
                805                 810                 815     


Thr Arg Thr Lys Leu Thr Val Glu Glu Leu Lys Ala Phe Val Gln Gln 
            820                 825                 830         


Leu Phe Ser Leu Pro Cys Val Ile Ser Gln Ala Arg Gln Val Lys Asn 
        835                 840                 845             


Leu Leu Asp Asp Val Glu Glu Phe His Glu Arg Ala Gln Glu Ala Met 
    850                 855                 860                 


Met Asp Glu Thr Pro Asp Ser Ser Lys Leu Gln Met Leu Ile Asp Met 
865                 870                 875                 880 


Gly Ser Ser Leu Tyr Val Glu Leu Pro Glu Leu Pro Arg Leu Lys Gln 
                885                 890                 895     


Glu Leu Gln Gln Ala Arg Trp Leu Asp Glu Val Arg Leu Thr Leu Ser 
            900                 905                 910         


Asp Pro Gln Gln Val Thr Leu Asp Val Met Lys Lys Leu Ile Asp Ser 
        915                 920                 925             


Gly Val Gly Leu Ala Pro His His Ala Val Glu Lys Ala Met Ala Glu 
    930                 935                 940                 


Leu Gln Glu Leu Leu Thr Val Ser Glu Arg Trp Glu Glu Lys Ala Lys 
945                 950                 955                 960 


Val Cys Leu Gln Ala Arg Pro Arg His Ser Val Ala Ser Leu Glu Ser 
                965                 970                 975     


Ile Val Asn Glu Ala Lys Asn Ile Pro Ala Phe Leu Pro Asn Val Leu 
            980                 985                 990         


Ser Leu Lys Glu Ala Leu Gln Lys  Ala Arg Glu Trp Thr  Ala Lys Val 
        995                 1000                 1005             


Glu Ala  Ile Gln Ser Gly Ser  Asn Tyr Ala Tyr Leu  Glu Gln Leu 
    1010                 1015                 1020             


Glu Ser  Leu Ser Ala Lys Gly  Arg Pro Ile Pro Val  Arg Leu Glu 
    1025                 1030                 1035             


Ala Leu  Pro Gln Val Glu Ser  Gln Val Ala Ala Ala  Arg Ala Trp 
    1040                 1045                 1050             


Arg Glu  Arg Thr Gly Arg Thr  Phe Leu Lys Lys Asn  Ser Ser His 
    1055                 1060                 1065             


Thr Leu  Leu Gln Val Leu Ser  Pro Arg Thr Asp Ile  Gly Val Tyr 
    1070                 1075                 1080             


Gly Ser  Gly Lys Asn Arg Arg  Lys Lys Val Lys Glu  Leu Ile Glu 
    1085                 1090                 1095             


Lys Glu  Lys Glu Lys Asp Leu  Asp Leu Glu Pro Leu  Ser Asp Leu 
    1100                 1105                 1110             


Glu Glu  Gly Leu Glu Glu Thr  Arg Asp Thr Ala Met  Val Val Ala 
    1115                 1120                 1125             


Val Phe  Lys Glu Arg Glu Gln  Lys Glu Ile Glu Ala  Met His Ser 
    1130                 1135                 1140             


Leu Arg  Ala Ala Asn Leu Ala  Lys Met Thr Met Val  Asp Arg Ile 
    1145                 1150                 1155             


Glu Glu  Val Lys Phe Cys Ile  Cys Arg Lys Thr Ala  Ser Gly Phe 
    1160                 1165                 1170             


Met Leu  Gln Cys Glu Leu Cys  Lys Asp Trp Phe His  Asn Ser Cys 
    1175                 1180                 1185             


Val Pro  Leu Pro Lys Ser Ser  Ser Gln Lys Lys Gly  Ser Ser Trp 
    1190                 1195                 1200             


Gln Ala  Lys Glu Val Lys Phe  Leu Cys Pro Leu Cys  Met Arg Ser 
    1205                 1210                 1215             


Arg Arg  Pro Arg Leu Glu Thr  Ile Leu Ser Leu Leu  Val Ser Leu 
    1220                 1225                 1230             


Gln Lys  Leu Pro Val Arg Leu  Pro Glu Gly Glu Ala  Leu Gln Cys 
    1235                 1240                 1245             


Leu Thr  Glu Arg Ala Met Ser  Trp Gln Asp Arg Ala  Arg Gln Ala 
    1250                 1255                 1260             


Leu Ala  Thr Asp Glu Leu Ser  Ser Ala Leu Ala Lys  Leu Ser Val 
    1265                 1270                 1275             


Leu Ser  Gln Arg Met Val Glu  Gln Ala Ala Arg Glu  Lys Thr Glu 
    1280                 1285                 1290             


Lys Ile  Ile Ser Ala Glu Leu  Gln Lys Ala Ala Ala  Asn Pro Asp 
    1295                 1300                 1305             


Leu Gln  Gly His Leu Pro Ser  Phe Gln Gln Ser Ala  Phe Asn Arg 
    1310                 1315                 1320             


Val Val  Ser Ser Val Ser Ser  Ser Pro Arg Gln Thr  Met Asp Tyr 
    1325                 1330                 1335             


Asp Asp  Glu Glu Thr Asp Ser  Asp Glu Asp Ile Arg  Glu Thr Tyr 
    1340                 1345                 1350             


Gly Tyr  Asp Met Lys Asp Thr  Ala Ser Val Lys Ser  Ser Ser Ser 
    1355                 1360                 1365             


Leu Glu  Pro Asn Leu Phe Cys  Asp Glu Glu Ile Pro  Ile Lys Ser 
    1370                 1375                 1380             


Glu Glu  Val Val Thr His Met  Trp Thr Ala Pro Ser  Phe Cys Ala 
    1385                 1390                 1395             


Glu His  Ala Tyr Ser Ser Ala  Ser Lys Ser Cys Ser  Gln Gly Ser 
    1400                 1405                 1410             


Ser Thr  Pro Arg Lys Gln Pro  Arg Lys Ser Pro Leu  Val Pro Arg 
    1415                 1420                 1425             


Ser Leu  Glu Pro Pro Val Leu  Glu Leu Ser Pro Gly  Ala Lys Ala 
    1430                 1435                 1440             


Gln Leu  Glu Glu Leu Met Met  Val Gly Asp Leu Leu  Glu Val Ser 
    1445                 1450                 1455             


Leu Asp  Glu Thr Gln His Ile  Trp Arg Ile Leu Gln  Ala Thr His 
    1460                 1465                 1470             


Pro Pro  Ser Glu Asp Arg Phe  Leu His Ile Met Glu  Asp Asp Ser 
    1475                 1480                 1485             


Met Glu  Glu Lys Pro Leu Lys  Val Lys Gly Lys Asp  Ser Ser Glu 
    1490                 1495                 1500             


Lys Lys  Arg Lys Arg Lys Leu  Glu Lys Val Glu Gln  Leu Phe Gly 
    1505                 1510                 1515             


Glu Gly  Lys Gln Lys Ser Lys  Glu Leu Lys Lys Met  Asp Lys Pro 
    1520                 1525                 1530             


Arg Lys  Lys Lys Leu Lys Leu  Gly Ala Asp Lys Ser  Lys Glu Leu 
    1535                 1540                 1545             


Asn Lys  Leu Ala Lys Lys Leu  Ala Lys Glu Glu Glu  Arg Lys Lys 
    1550                 1555                 1560             


Lys Lys  Glu Lys Ala Ala Ala  Ala Lys Val Glu Leu  Val Lys Glu 
    1565                 1570                 1575             


Ser Thr  Glu Lys Lys Arg Glu  Lys Lys Val Leu Asp  Ile Pro Ser 
    1580                 1585                 1590             


Lys Tyr  Asp Trp Ser Gly Ala  Glu Glu Ser Asp Asp  Glu Asn Ala 
    1595                 1600                 1605             


Val Cys  Ala Ala Gln Asn Cys  Gln Arg Pro Cys Lys  Asp Lys Val 
    1610                 1615                 1620             


Asp Trp  Val Gln Cys Asp Gly  Gly Cys Asp Glu Trp  Phe His Gln 
    1625                 1630                 1635             


Val Cys  Val Gly Val Ser Pro  Glu Met Ala Glu Asn  Glu Asp Tyr 
    1640                 1645                 1650             


Ile Cys  Ile Asn Cys Ala Lys  Lys Gln Gly Pro Val  Ser Pro Gly 
    1655                 1660                 1665             


Pro Ala  Pro Pro Pro Ser Phe  Ile Met Ser Tyr Lys  Leu Pro Met 
    1670                 1675                 1680             


Glu Asp  Leu Lys Glu Thr Ser  
    1685                 1690 


<210>  91
<211>  1388
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (112)..(1041)

<400>  91
gtctctgcca agcgcctgtt ggtaggaacc tgcttggtcg cgtctgaggg ggcttgtagg       60

tggctctggc tgaaacaggc gcctgcgaga gtctgtagga gggaaaccgc c atg gac       117
                                                         Met Asp          
                                                         1                

gat cag ggt tgc cct cgg tgt aag acc acc aaa tat cgg aac ccc tcc        165
Asp Gln Gly Cys Pro Arg Cys Lys Thr Thr Lys Tyr Arg Asn Pro Ser           
        5                   10                  15                        

ttg aag ctg atg gtg aat gtg tgc gga cac act ctc tgt gaa agt tgt        213
Leu Lys Leu Met Val Asn Val Cys Gly His Thr Leu Cys Glu Ser Cys           
    20                  25                  30                            

gta gat tta ctg ttt gtg aga gga gct gga aac tgc cct gag tgt ggt        261
Val Asp Leu Leu Phe Val Arg Gly Ala Gly Asn Cys Pro Glu Cys Gly           
35                  40                  45                  50            

act cca ctc aga aag agc aac ttc agg gta caa ctc ttt gaa gat ccc        309
Thr Pro Leu Arg Lys Ser Asn Phe Arg Val Gln Leu Phe Glu Asp Pro           
                55                  60                  65                

act gtt gac aag gag gtt gag atc agg aaa aaa gtg cta aag ata tac        357
Thr Val Asp Lys Glu Val Glu Ile Arg Lys Lys Val Leu Lys Ile Tyr           
            70                  75                  80                    

aat aaa agg gaa gaa gat ttt cct agt cta aga gaa tac aat gat ttc        405
Asn Lys Arg Glu Glu Asp Phe Pro Ser Leu Arg Glu Tyr Asn Asp Phe           
        85                  90                  95                        

ttg gaa gaa gtg gaa gaa att gtt ttc aac ttg acc aac aat gtg gat        453
Leu Glu Glu Val Glu Glu Ile Val Phe Asn Leu Thr Asn Asn Val Asp           
    100                 105                 110                           

ttg gac aac acc aaa aag aaa atg gag ata tac caa aag gaa aac aaa        501
Leu Asp Asn Thr Lys Lys Lys Met Glu Ile Tyr Gln Lys Glu Asn Lys           
115                 120                 125                 130           

gat gtt att cag aaa aat aaa tta aag ctg act cga gaa cag gaa gaa        549
Asp Val Ile Gln Lys Asn Lys Leu Lys Leu Thr Arg Glu Gln Glu Glu           
                135                 140                 145               

ctg gaa gaa gct tta gaa gtg gaa cga cag gaa aat gaa caa aga aga        597
Leu Glu Glu Ala Leu Glu Val Glu Arg Gln Glu Asn Glu Gln Arg Arg           
            150                 155                 160                   

tta ttt ata caa aaa gaa gaa caa ctg cag cag att cta aaa agg aag        645
Leu Phe Ile Gln Lys Glu Glu Gln Leu Gln Gln Ile Leu Lys Arg Lys           
        165                 170                 175                       

aat aag cag gct ttt tta gat gag ctg gag agt tct gat ctc cct gtt        693
Asn Lys Gln Ala Phe Leu Asp Glu Leu Glu Ser Ser Asp Leu Pro Val           
    180                 185                 190                           

gct ctg ctt ttg gct cag cat aaa gat aga tct acc caa tta gaa atg        741
Ala Leu Leu Leu Ala Gln His Lys Asp Arg Ser Thr Gln Leu Glu Met           
195                 200                 205                 210           

caa ctt gag aaa ccc aaa cct gta aaa cca gtg acg ttt tcc aca ggc        789
Gln Leu Glu Lys Pro Lys Pro Val Lys Pro Val Thr Phe Ser Thr Gly           
                215                 220                 225               

atc aaa atg ggt caa cat att tca ctg gca cct att cac aag ctt gaa        837
Ile Lys Met Gly Gln His Ile Ser Leu Ala Pro Ile His Lys Leu Glu           
            230                 235                 240                   

gaa gct ctg tat gaa tac cag cca ctg cag ata gag aca tat gga cca        885
Glu Ala Leu Tyr Glu Tyr Gln Pro Leu Gln Ile Glu Thr Tyr Gly Pro           
        245                 250                 255                       

cat gtt cct gag ctt gag atg cta gga aga ctt ggg tat tta aac cat        933
His Val Pro Glu Leu Glu Met Leu Gly Arg Leu Gly Tyr Leu Asn His           
    260                 265                 270                           

gtc aga gct gcc tca cca cag gac ctt gct gga ggc tat act tct tct        981
Val Arg Ala Ala Ser Pro Gln Asp Leu Ala Gly Gly Tyr Thr Ser Ser           
275                 280                 285                 290           

ctt gct tgt cac aga gca cta cag gat gca ttc agt ggg ctt ttc tgg       1029
Leu Ala Cys His Arg Ala Leu Gln Asp Ala Phe Ser Gly Leu Phe Trp           
                295                 300                 305               

cag ccc agt taa ccatttataa gatttggacc ttggagctga accagggagc           1081
Gln Pro Ser                                                               
                                                                          

tagcaaaagt aaagcagact tataaaatta tagctatgtg cagctgcaca acacagtcct     1141

tccactagca gctgtgttaa agtatttata aggagaaaat ttcagaacta agttgagtaa     1201

tataggggat atatatttgt gaaaaataat ttttacttat atttttcaga ggatttgaca     1261

cgataagcct catctgatgg aagagaggaa taaataattc acctatatgt gtttgaggtt     1321

gtgacagact tataaaatct ttttaaaaaa taaagctata atttatatta aaaaaaaaaa     1381

aaataaa                                                               1388


<210>  92
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Asp Asp Gln Gly Cys Pro Arg Cys Lys Thr Thr Lys Tyr Arg Asn 
1               5                   10                  15      


Pro Ser Leu Lys Leu Met Val Asn Val Cys Gly His Thr Leu Cys Glu 
            20                  25                  30          


Ser Cys Val Asp Leu Leu Phe Val Arg Gly Ala Gly Asn Cys Pro Glu 
        35                  40                  45              


Cys Gly Thr Pro Leu Arg Lys Ser Asn Phe Arg Val Gln Leu Phe Glu 
    50                  55                  60                  


Asp Pro Thr Val Asp Lys Glu Val Glu Ile Arg Lys Lys Val Leu Lys 
65                  70                  75                  80  


Ile Tyr Asn Lys Arg Glu Glu Asp Phe Pro Ser Leu Arg Glu Tyr Asn 
                85                  90                  95      


Asp Phe Leu Glu Glu Val Glu Glu Ile Val Phe Asn Leu Thr Asn Asn 
            100                 105                 110         


Val Asp Leu Asp Asn Thr Lys Lys Lys Met Glu Ile Tyr Gln Lys Glu 
        115                 120                 125             


Asn Lys Asp Val Ile Gln Lys Asn Lys Leu Lys Leu Thr Arg Glu Gln 
    130                 135                 140                 


Glu Glu Leu Glu Glu Ala Leu Glu Val Glu Arg Gln Glu Asn Glu Gln 
145                 150                 155                 160 


Arg Arg Leu Phe Ile Gln Lys Glu Glu Gln Leu Gln Gln Ile Leu Lys 
                165                 170                 175     


Arg Lys Asn Lys Gln Ala Phe Leu Asp Glu Leu Glu Ser Ser Asp Leu 
            180                 185                 190         


Pro Val Ala Leu Leu Leu Ala Gln His Lys Asp Arg Ser Thr Gln Leu 
        195                 200                 205             


Glu Met Gln Leu Glu Lys Pro Lys Pro Val Lys Pro Val Thr Phe Ser 
    210                 215                 220                 


Thr Gly Ile Lys Met Gly Gln His Ile Ser Leu Ala Pro Ile His Lys 
225                 230                 235                 240 


Leu Glu Glu Ala Leu Tyr Glu Tyr Gln Pro Leu Gln Ile Glu Thr Tyr 
                245                 250                 255     


Gly Pro His Val Pro Glu Leu Glu Met Leu Gly Arg Leu Gly Tyr Leu 
            260                 265                 270         


Asn His Val Arg Ala Ala Ser Pro Gln Asp Leu Ala Gly Gly Tyr Thr 
        275                 280                 285             


Ser Ser Leu Ala Cys His Arg Ala Leu Gln Asp Ala Phe Ser Gly Leu 
    290                 295                 300                 


Phe Trp Gln Pro Ser 
305                 


<210>  93
<211>  3616
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (103)..(2082)

<400>  93
ctctgctctc ctcccagtct cccccgcgct gcgtgcagta aggtagccgc cgccgccgcc       60

gccgccgcgt cccctcgccg gctcgctggt accggcagtg cc atg gcg gcc ttc         114
                                               Met Ala Ala Phe            
                                               1                          

agc aag tac ttg acg gcg cga aac tcc tcg ctg gct ggt gcc gcg ttc        162
Ser Lys Tyr Leu Thr Ala Arg Asn Ser Ser Leu Ala Gly Ala Ala Phe           
5                   10                  15                  20            

ctg ctg ctc tgc ctg ctc cac aag cgg cgc cgc gcc ctc ggc ctg cac        210
Leu Leu Leu Cys Leu Leu His Lys Arg Arg Arg Ala Leu Gly Leu His           
                25                  30                  35                

ggt aag aaa agt gga aaa cca cca tta cag aac aat gag aaa gag ggg        258
Gly Lys Lys Ser Gly Lys Pro Pro Leu Gln Asn Asn Glu Lys Glu Gly           
            40                  45                  50                    

aaa aag gag cga gct gtg gtg gac aag gtg ttt ttc tca agg ctc ata        306
Lys Lys Glu Arg Ala Val Val Asp Lys Val Phe Phe Ser Arg Leu Ile           
        55                  60                  65                        

cag att ctg aaa atc atg gtc cct aga aca ttt tgt aaa gag aca ggt        354
Gln Ile Leu Lys Ile Met Val Pro Arg Thr Phe Cys Lys Glu Thr Gly           
    70                  75                  80                            

tac ttg gta ctt att gct gtt atg ctg gtg tct cga aca tat tgt gat        402
Tyr Leu Val Leu Ile Ala Val Met Leu Val Ser Arg Thr Tyr Cys Asp           
85                  90                  95                  100           

gtt tgg atg att caa aat ggg aca cta att gaa agt ggt atc att ggt        450
Val Trp Met Ile Gln Asn Gly Thr Leu Ile Glu Ser Gly Ile Ile Gly           
                105                 110                 115               

cgt agc agg aaa gat ttc aag aga tac tta ctc aac ttc atc gct gcc        498
Arg Ser Arg Lys Asp Phe Lys Arg Tyr Leu Leu Asn Phe Ile Ala Ala           
            120                 125                 130                   

atg cct ctt atc tct ctg gtt aat aac ttc ttg aag tat ggg tta aat        546
Met Pro Leu Ile Ser Leu Val Asn Asn Phe Leu Lys Tyr Gly Leu Asn           
        135                 140                 145                       

gag ctt aaa ctg tgc ttc cga gta agg ctc act aaa tac ctc tat gag        594
Glu Leu Lys Leu Cys Phe Arg Val Arg Leu Thr Lys Tyr Leu Tyr Glu           
    150                 155                 160                           

gag tat ctt caa gct ttc aca tat tat aaa atg ggg aat ctg gac aac        642
Glu Tyr Leu Gln Ala Phe Thr Tyr Tyr Lys Met Gly Asn Leu Asp Asn           
165                 170                 175                 180           

aga ata gct aat cca gac cag ctg ctt aca caa gat gta gaa aaa ttt        690
Arg Ile Ala Asn Pro Asp Gln Leu Leu Thr Gln Asp Val Glu Lys Phe           
                185                 190                 195               

tgt aac agt gta gtc gat ctg tat tca aat ctt agt aag cca ttt tta        738
Cys Asn Ser Val Val Asp Leu Tyr Ser Asn Leu Ser Lys Pro Phe Leu           
            200                 205                 210                   

gac ata gtt ttg tat atc ttt aag tta acg agt gca att gga gct cag        786
Asp Ile Val Leu Tyr Ile Phe Lys Leu Thr Ser Ala Ile Gly Ala Gln           
        215                 220                 225                       

ggc cca gcg agc atg atg gcc tac ttg gtt gtt tct ggg cta ttc cta        834
Gly Pro Ala Ser Met Met Ala Tyr Leu Val Val Ser Gly Leu Phe Leu           
    230                 235                 240                           

act cga ctt cga aga ccc att ggt aag atg aca ata act gag caa aag        882
Thr Arg Leu Arg Arg Pro Ile Gly Lys Met Thr Ile Thr Glu Gln Lys           
245                 250                 255                 260           

tat gaa gga gaa tat aga tat gtt aat tct cgg ctc atc aca aac agt        930
Tyr Glu Gly Glu Tyr Arg Tyr Val Asn Ser Arg Leu Ile Thr Asn Ser           
                265                 270                 275               

gaa gaa att gcc ttt tac aat ggg aat aaa aga gaa aag cag aca gtc        978
Glu Glu Ile Ala Phe Tyr Asn Gly Asn Lys Arg Glu Lys Gln Thr Val           
            280                 285                 290                   

cac tca gtc ttc cga aaa ctg gtg gaa cac cta cat aat ttc att ttg       1026
His Ser Val Phe Arg Lys Leu Val Glu His Leu His Asn Phe Ile Leu           
        295                 300                 305                       

ttt cgg ttt tca atg ggc ttc att gat agt att att gcc aaa tac ctt       1074
Phe Arg Phe Ser Met Gly Phe Ile Asp Ser Ile Ile Ala Lys Tyr Leu           
    310                 315                 320                           

gcc act gtt gtt ggt tac cta gtt gtc agt cgc cct ttc tta gat ttg       1122
Ala Thr Val Val Gly Tyr Leu Val Val Ser Arg Pro Phe Leu Asp Leu           
325                 330                 335                 340           

tct cat cct cga cat ctc aag agt aca cat tcg gaa ctt cta gag gat       1170
Ser His Pro Arg His Leu Lys Ser Thr His Ser Glu Leu Leu Glu Asp           
                345                 350                 355               

tac tac caa agt gga aga atg ctt ttg cga atg tct caa gct ctg ggt       1218
Tyr Tyr Gln Ser Gly Arg Met Leu Leu Arg Met Ser Gln Ala Leu Gly           
            360                 365                 370                   

cga ata gtt ttg gct ggg cgt gaa atg act aga ttg gcc ggt ttt act       1266
Arg Ile Val Leu Ala Gly Arg Glu Met Thr Arg Leu Ala Gly Phe Thr           
        375                 380                 385                       

gct cgg att aca gaa tta atg caa gta ctg aag gat tta aat cat ggc       1314
Ala Arg Ile Thr Glu Leu Met Gln Val Leu Lys Asp Leu Asn His Gly           
    390                 395                 400                           

aaa tat gag cgc aca atg gtc tca caa cag gaa aag ggt att gaa gga       1362
Lys Tyr Glu Arg Thr Met Val Ser Gln Gln Glu Lys Gly Ile Glu Gly           
405                 410                 415                 420           

gta caa gtc att ccc ttg ata cct ggt gct gga gaa atc att att gca       1410
Val Gln Val Ile Pro Leu Ile Pro Gly Ala Gly Glu Ile Ile Ile Ala           
                425                 430                 435               

gat aac att ata aag ttt gat cat gtt cct tta gca acg cca aat gga       1458
Asp Asn Ile Ile Lys Phe Asp His Val Pro Leu Ala Thr Pro Asn Gly           
            440                 445                 450                   

gat gtt ttg atc cga gac ctt aat ttt gaa gtt cga tct ggg gct aat       1506
Asp Val Leu Ile Arg Asp Leu Asn Phe Glu Val Arg Ser Gly Ala Asn           
        455                 460                 465                       

gtt cta att tgt ggt cca aat ggc tgc gga aag agt tca ctt ttc cgt       1554
Val Leu Ile Cys Gly Pro Asn Gly Cys Gly Lys Ser Ser Leu Phe Arg           
    470                 475                 480                           

gtt ctt ggt gaa tta tgg cct ctt ttt gga gga cgt cta act aaa cct       1602
Val Leu Gly Glu Leu Trp Pro Leu Phe Gly Gly Arg Leu Thr Lys Pro           
485                 490                 495                 500           

gaa aga gga aaa tta ttt tat gtt cct cag aga cct tac atg acc ctt       1650
Glu Arg Gly Lys Leu Phe Tyr Val Pro Gln Arg Pro Tyr Met Thr Leu           
                505                 510                 515               

gga aca ctt cga gat caa gtg ata tat cca gat gga cga gaa gat cag       1698
Gly Thr Leu Arg Asp Gln Val Ile Tyr Pro Asp Gly Arg Glu Asp Gln           
            520                 525                 530                   

aaa agg aag gga att tct gac cta gta ctg aag gaa tac tta gac aat       1746
Lys Arg Lys Gly Ile Ser Asp Leu Val Leu Lys Glu Tyr Leu Asp Asn           
        535                 540                 545                       

gtc cag ttg ggt cat atc ctt gaa cgt gaa gga ggc tgg gac agt gtt       1794
Val Gln Leu Gly His Ile Leu Glu Arg Glu Gly Gly Trp Asp Ser Val           
    550                 555                 560                           

cag gat tgg atg gac gta ctc agt ggt gga gaa aag caa aga atg gcg       1842
Gln Asp Trp Met Asp Val Leu Ser Gly Gly Glu Lys Gln Arg Met Ala           
565                 570                 575                 580           

atg gca aga tta ttt tat cat aaa ccc cag ttt gcc att ttg gat gaa       1890
Met Ala Arg Leu Phe Tyr His Lys Pro Gln Phe Ala Ile Leu Asp Glu           
                585                 590                 595               

tgc aca agt gca gtt agt gtc gac gtg gaa ggc tac att tat agt cat       1938
Cys Thr Ser Ala Val Ser Val Asp Val Glu Gly Tyr Ile Tyr Ser His           
            600                 605                 610                   

tgt cga aag gtt ggc atc act ctc ttc act gtg tct cat agg aaa tct       1986
Cys Arg Lys Val Gly Ile Thr Leu Phe Thr Val Ser His Arg Lys Ser           
        615                 620                 625                       

ctt tgg aaa cat cat gag tac tac ctg cat atg gat ggc aga ggc aac       2034
Leu Trp Lys His His Glu Tyr Tyr Leu His Met Asp Gly Arg Gly Asn           
    630                 635                 640                           

tat gaa ttc aaa cag ata aca gaa gat aca gtt gag ttt ggc tct tag       2082
Tyr Glu Phe Lys Gln Ile Thr Glu Asp Thr Val Glu Phe Gly Ser               
645                 650                 655                               

agaaatctgg agaactatac ctgcttcagt gaaataatta cagaatatac ttagaaaggc     2142

aaagtacatt gtaaaataaa gttgagctta gtttttttta aaaaaaaaaa caaagcaaca     2202

aattaactag atacagaata atggagaaca agttgttaaa acatttaata ttatatagga     2262

tattgctaat tgtgtatatg ttggtttaat taataatatg tactaagaat gtccttattc     2322

ttgtggttaa aaacctgcct aaattaaatt gggcttcaat cactgtaacc tgattcatcc     2382

tgggatgtaa accattcgaa gtcagctaat tggactttta tggctctatc ttttccttca     2442

gtgaagaacc ctatttaaaa ctgggtcatc atttgtcctg ttctagcaag atagtcttca     2502

gtttcatttt cctgtgccct gtggtagttg gaaacaaatc ataatgtatt atttaaatgt     2562

ttaacatcat tgcataacag cgtttattat acagtggcag atttctttag ctgccacagt     2622

aatactcatt ccttgtgtgt gtcttggagt gcatttgact ccaggaaaag ccattttggt     2682

tttccttaac taaatgataa atgtacccct ctcagtctgc agtattgagt tgtttaaagt     2742

atatgtgcag tcttgcttac aaggaggggt taccatgtat cacacctaat cttcccaatg     2802

tttgggatat taaaacacaa agtccttaac atgccaggct caaggtctta taagagttct     2862

agatttttaa gagaattaga caaatttgtg tgtgttagaa gcccattcat tagaagtgtg     2922

gtggttattt ggtattaaac tccaaatgag ccataggaag gcactacatg aaataatgca     2982

ctgagtatgc aatgctatca ctgtctttga ctgtgatttt atgtttaaaa agtatgttct     3042

aaaattatta tatatacatg ggtgaattat gtttccgagg cactgtttta tctctgtgaa     3102

tcttgaataa cttttttata tttgggttat gatgtcaaac gatcctaagc gaagatgatt     3162

tcagttcatc aaatcatcat taatgacttt atgtattatt tgcacaggga gaattgaaac     3222

tgagtataat caataagcta gatacgaaat cagtttctca aactgagctt cagaaagggg     3282

cattttgtac tcttgttttt gcataactgg ttttgttttt ttgcagaatt aactataaca     3342

atcactggct accgaagtaa actgatgtac tgaattccat aatacataac attcaatttt     3402

taccacttct gtttagcgaa cttgtatact tattttctgt tcagattaaa aaaaaaaaaa     3462

aaaaactcag atatcctata caacctttgc ttgttctttt tattctggta tctaaatact     3522

gagaagttca tttataattc agccttgact tgaaaacata gatagtttaa tcttgacttg     3582

aaaaacacaa aaataaattc agaaaatgct ttta                                 3616


<210>  94
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ala Ala Phe Ser Lys Tyr Leu Thr Ala Arg Asn Ser Ser Leu Ala 
1               5                   10                  15      


Gly Ala Ala Phe Leu Leu Leu Cys Leu Leu His Lys Arg Arg Arg Ala 
            20                  25                  30          


Leu Gly Leu His Gly Lys Lys Ser Gly Lys Pro Pro Leu Gln Asn Asn 
        35                  40                  45              


Glu Lys Glu Gly Lys Lys Glu Arg Ala Val Val Asp Lys Val Phe Phe 
    50                  55                  60                  


Ser Arg Leu Ile Gln Ile Leu Lys Ile Met Val Pro Arg Thr Phe Cys 
65                  70                  75                  80  


Lys Glu Thr Gly Tyr Leu Val Leu Ile Ala Val Met Leu Val Ser Arg 
                85                  90                  95      


Thr Tyr Cys Asp Val Trp Met Ile Gln Asn Gly Thr Leu Ile Glu Ser 
            100                 105                 110         


Gly Ile Ile Gly Arg Ser Arg Lys Asp Phe Lys Arg Tyr Leu Leu Asn 
        115                 120                 125             


Phe Ile Ala Ala Met Pro Leu Ile Ser Leu Val Asn Asn Phe Leu Lys 
    130                 135                 140                 


Tyr Gly Leu Asn Glu Leu Lys Leu Cys Phe Arg Val Arg Leu Thr Lys 
145                 150                 155                 160 


Tyr Leu Tyr Glu Glu Tyr Leu Gln Ala Phe Thr Tyr Tyr Lys Met Gly 
                165                 170                 175     


Asn Leu Asp Asn Arg Ile Ala Asn Pro Asp Gln Leu Leu Thr Gln Asp 
            180                 185                 190         


Val Glu Lys Phe Cys Asn Ser Val Val Asp Leu Tyr Ser Asn Leu Ser 
        195                 200                 205             


Lys Pro Phe Leu Asp Ile Val Leu Tyr Ile Phe Lys Leu Thr Ser Ala 
    210                 215                 220                 


Ile Gly Ala Gln Gly Pro Ala Ser Met Met Ala Tyr Leu Val Val Ser 
225                 230                 235                 240 


Gly Leu Phe Leu Thr Arg Leu Arg Arg Pro Ile Gly Lys Met Thr Ile 
                245                 250                 255     


Thr Glu Gln Lys Tyr Glu Gly Glu Tyr Arg Tyr Val Asn Ser Arg Leu 
            260                 265                 270         


Ile Thr Asn Ser Glu Glu Ile Ala Phe Tyr Asn Gly Asn Lys Arg Glu 
        275                 280                 285             


Lys Gln Thr Val His Ser Val Phe Arg Lys Leu Val Glu His Leu His 
    290                 295                 300                 


Asn Phe Ile Leu Phe Arg Phe Ser Met Gly Phe Ile Asp Ser Ile Ile 
305                 310                 315                 320 


Ala Lys Tyr Leu Ala Thr Val Val Gly Tyr Leu Val Val Ser Arg Pro 
                325                 330                 335     


Phe Leu Asp Leu Ser His Pro Arg His Leu Lys Ser Thr His Ser Glu 
            340                 345                 350         


Leu Leu Glu Asp Tyr Tyr Gln Ser Gly Arg Met Leu Leu Arg Met Ser 
        355                 360                 365             


Gln Ala Leu Gly Arg Ile Val Leu Ala Gly Arg Glu Met Thr Arg Leu 
    370                 375                 380                 


Ala Gly Phe Thr Ala Arg Ile Thr Glu Leu Met Gln Val Leu Lys Asp 
385                 390                 395                 400 


Leu Asn His Gly Lys Tyr Glu Arg Thr Met Val Ser Gln Gln Glu Lys 
                405                 410                 415     


Gly Ile Glu Gly Val Gln Val Ile Pro Leu Ile Pro Gly Ala Gly Glu 
            420                 425                 430         


Ile Ile Ile Ala Asp Asn Ile Ile Lys Phe Asp His Val Pro Leu Ala 
        435                 440                 445             


Thr Pro Asn Gly Asp Val Leu Ile Arg Asp Leu Asn Phe Glu Val Arg 
    450                 455                 460                 


Ser Gly Ala Asn Val Leu Ile Cys Gly Pro Asn Gly Cys Gly Lys Ser 
465                 470                 475                 480 


Ser Leu Phe Arg Val Leu Gly Glu Leu Trp Pro Leu Phe Gly Gly Arg 
                485                 490                 495     


Leu Thr Lys Pro Glu Arg Gly Lys Leu Phe Tyr Val Pro Gln Arg Pro 
            500                 505                 510         


Tyr Met Thr Leu Gly Thr Leu Arg Asp Gln Val Ile Tyr Pro Asp Gly 
        515                 520                 525             


Arg Glu Asp Gln Lys Arg Lys Gly Ile Ser Asp Leu Val Leu Lys Glu 
    530                 535                 540                 


Tyr Leu Asp Asn Val Gln Leu Gly His Ile Leu Glu Arg Glu Gly Gly 
545                 550                 555                 560 


Trp Asp Ser Val Gln Asp Trp Met Asp Val Leu Ser Gly Gly Glu Lys 
                565                 570                 575     


Gln Arg Met Ala Met Ala Arg Leu Phe Tyr His Lys Pro Gln Phe Ala 
            580                 585                 590         


Ile Leu Asp Glu Cys Thr Ser Ala Val Ser Val Asp Val Glu Gly Tyr 
        595                 600                 605             


Ile Tyr Ser His Cys Arg Lys Val Gly Ile Thr Leu Phe Thr Val Ser 
    610                 615                 620                 


His Arg Lys Ser Leu Trp Lys His His Glu Tyr Tyr Leu His Met Asp 
625                 630                 635                 640 


Gly Arg Gly Asn Tyr Glu Phe Lys Gln Ile Thr Glu Asp Thr Val Glu 
                645                 650                 655     


Phe Gly Ser 
            


<210>  95
<211>  4016
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (58)..(1740)

<400>  95
gcgctgtcgc cgccgccgct gcagccggag ttggaggagg gagaagctag gaagaaa          57

atg gcg gcc gtg gct gca gag gcg gca gcg act gca gcg tcc ccc ggg        105
Met Ala Ala Val Ala Ala Glu Ala Ala Ala Thr Ala Ala Ser Pro Gly           
1               5                   10                  15                

gag ggg ggc gcc ggc gag gcc gag ccg gag atg gag ccc atc ccc ggc        153
Glu Gly Gly Ala Gly Glu Ala Glu Pro Glu Met Glu Pro Ile Pro Gly           
            20                  25                  30                    

agt gag gcc ggc act gac ccc ctc ccg gtc acg gcc act gaa gcg tct        201
Ser Glu Ala Gly Thr Asp Pro Leu Pro Val Thr Ala Thr Glu Ala Ser           
        35                  40                  45                        

gtg ccg gat ggc gag act gac ggg cag caa tcc gct cct cag gcc gac        249
Val Pro Asp Gly Glu Thr Asp Gly Gln Gln Ser Ala Pro Gln Ala Asp           
    50                  55                  60                            

gag ccg ccg ctc ccg ccg cca ccg ccg ccg ccg ggg gag ctc gcc cgc        297
Glu Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Gly Glu Leu Ala Arg           
65                  70                  75                  80            

agc cca gag gcg gtg ggg ccg gag ctg gag gct gag gag aaa ctg tcc        345
Ser Pro Glu Ala Val Gly Pro Glu Leu Glu Ala Glu Glu Lys Leu Ser           
                85                  90                  95                

gtt cgg gtg gcg gag tcg gcg gca gcc gcg cct cag gga ggg ccg gaa        393
Val Arg Val Ala Glu Ser Ala Ala Ala Ala Pro Gln Gly Gly Pro Glu           
            100                 105                 110                   

ctt cca cct tct cct gca tcg ccg ccg gag cag ccc ccg gct ccc gag        441
Leu Pro Pro Ser Pro Ala Ser Pro Pro Glu Gln Pro Pro Ala Pro Glu           
        115                 120                 125                       

gag cgc gag gag ccg ccg ctg cct cag ccc gta gcc ccg gcg ctc gtg        489
Glu Arg Glu Glu Pro Pro Leu Pro Gln Pro Val Ala Pro Ala Leu Val           
    130                 135                 140                           

ccg ccg gcg ggc ggg gac tcc acg gtg tcg caa ctg atc ccg ggc tcg        537
Pro Pro Ala Gly Gly Asp Ser Thr Val Ser Gln Leu Ile Pro Gly Ser           
145                 150                 155                 160           

gag gtg cgg gtc acg ctg gac cac atc att gag gac gcg ctt gtc gtg        585
Glu Val Arg Val Thr Leu Asp His Ile Ile Glu Asp Ala Leu Val Val           
                165                 170                 175               

tcg ttc cgc ttc ggg gag aag ctc ttc tcc ggg gtc ctc atg gat ctg        633
Ser Phe Arg Phe Gly Glu Lys Leu Phe Ser Gly Val Leu Met Asp Leu           
            180                 185                 190                   

tcc aaa agg ttt ggg ccc cat ggt atc cct gtg aca gta ttt ccc aaa        681
Ser Lys Arg Phe Gly Pro His Gly Ile Pro Val Thr Val Phe Pro Lys           
        195                 200                 205                       

agg gaa tat aag gat aaa cca gaa gcc atg ccg ctc caa agt aat aca        729
Arg Glu Tyr Lys Asp Lys Pro Glu Ala Met Pro Leu Gln Ser Asn Thr           
    210                 215                 220                           

ttc caa gaa ggg aca gaa gtc aag tgt gaa gca aat ggt gct gtt ccc        777
Phe Gln Glu Gly Thr Glu Val Lys Cys Glu Ala Asn Gly Ala Val Pro           
225                 230                 235                 240           

gat gac cct tct cct gtc ccg cat ccc gag ctg agc ttg gct gaa agc        825
Asp Asp Pro Ser Pro Val Pro His Pro Glu Leu Ser Leu Ala Glu Ser           
                245                 250                 255               

ctg tgg act tcc aaa cca cca cct ctc ttc cat gaa gga gca cct tat        873
Leu Trp Thr Ser Lys Pro Pro Pro Leu Phe His Glu Gly Ala Pro Tyr           
            260                 265                 270                   

cct ccc cct ttg ttt atc agg gac aca tat aac caa tca ata cct cag        921
Pro Pro Pro Leu Phe Ile Arg Asp Thr Tyr Asn Gln Ser Ile Pro Gln           
        275                 280                 285                       

cca cct cct cgg aaa att aag cga ccc aaa cga aaa atg tac agg gaa        969
Pro Pro Pro Arg Lys Ile Lys Arg Pro Lys Arg Lys Met Tyr Arg Glu           
    290                 295                 300                           

gaa ccc act tca ata atg aat gct att aaa cta cga ccc agg caa gtt       1017
Glu Pro Thr Ser Ile Met Asn Ala Ile Lys Leu Arg Pro Arg Gln Val           
305                 310                 315                 320           

ctg tgt gat aaa tgt aaa aac agt gtt gtt gct gaa aaa aag gaa att       1065
Leu Cys Asp Lys Cys Lys Asn Ser Val Val Ala Glu Lys Lys Glu Ile           
                325                 330                 335               

aga aaa ggt agt agt gca act gac tct tct aaa tat gaa gat aaa aaa       1113
Arg Lys Gly Ser Ser Ala Thr Asp Ser Ser Lys Tyr Glu Asp Lys Lys           
            340                 345                 350                   

cgg aga aat gaa agt gta act act gtg aac aaa aaa ctg aaa act gac       1161
Arg Arg Asn Glu Ser Val Thr Thr Val Asn Lys Lys Leu Lys Thr Asp           
        355                 360                 365                       

cat aaa gtg gat ggg aaa aac caa aat gaa agc cag aaa aga aat gct       1209
His Lys Val Asp Gly Lys Asn Gln Asn Glu Ser Gln Lys Arg Asn Ala           
    370                 375                 380                           

gtg gtt aag gtt tca aat att gct cac agc aga ggc aga gta gta aaa       1257
Val Val Lys Val Ser Asn Ile Ala His Ser Arg Gly Arg Val Val Lys           
385                 390                 395                 400           

gtt tct gct cag gca aat aca tca aaa gct cag tta agt act aaa aaa       1305
Val Ser Ala Gln Ala Asn Thr Ser Lys Ala Gln Leu Ser Thr Lys Lys           
                405                 410                 415               

gtt ctc cag agt aag aac atg gat cat gcg aaa gct cgg gaa gtg tta       1353
Val Leu Gln Ser Lys Asn Met Asp His Ala Lys Ala Arg Glu Val Leu           
            420                 425                 430                   

aaa att gcc aaa gaa aag gca caa aag aag caa aat gaa acc tct act       1401
Lys Ile Ala Lys Glu Lys Ala Gln Lys Lys Gln Asn Glu Thr Ser Thr           
        435                 440                 445                       

tcc aaa aat gca cat tca aaa gtc cat ttc aca cgt cga tat cag aat       1449
Ser Lys Asn Ala His Ser Lys Val His Phe Thr Arg Arg Tyr Gln Asn           
    450                 455                 460                           

cct agc tca ggt tcc ctt cca ccc cgg gtt cgt tta aaa cca cag agg       1497
Pro Ser Ser Gly Ser Leu Pro Pro Arg Val Arg Leu Lys Pro Gln Arg           
465                 470                 475                 480           

tac agg aat gaa gaa aat gac tct tct ctg aag aca gga ctt gag aaa       1545
Tyr Arg Asn Glu Glu Asn Asp Ser Ser Leu Lys Thr Gly Leu Glu Lys           
                485                 490                 495               

atg cgg agt ggc aag atg gca ccc aag ccc cag tct cgc tgc acc tct       1593
Met Arg Ser Gly Lys Met Ala Pro Lys Pro Gln Ser Arg Cys Thr Ser           
            500                 505                 510                   

acc cgc tca gca ggt ctc aac aaa tgg cag cta tta cat cag aca gtg       1641
Thr Arg Ser Ala Gly Leu Asn Lys Trp Gln Leu Leu His Gln Thr Val           
        515                 520                 525                       

acg agt cct gct gct ccc tta cag tgt ctg aca gac cac tgt gga ttc       1689
Thr Ser Pro Ala Ala Pro Leu Gln Cys Leu Thr Asp His Cys Gly Phe           
    530                 535                 540                           

aga ctg gga gca ttg aag tta aca gtg aaa cgg gca gca caa aga cat       1737
Arg Leu Gly Ala Leu Lys Leu Thr Val Lys Arg Ala Ala Gln Arg His           
545                 550                 555                 560           

tag caggctgctg gtttcatgga cctgtaccac aatgacacag agaacaccag            1790

agcatcagga ctgaatgaaa ttggagtttt taaagctgca ctaagaagta aatgttaagg     1850

cagtggttaa aaacaacagt ctataaaggg gcacttgcaa attgtgctgt cttaaaccga     1910

agaaaaggta ttagggaata ttttataaaa aataaacttg caataaatta tgcatgagat     1970

gaggagaaaa atgatgtgaa ttacacacgt aagaactcac ttgaatttta tatatgaaga     2030

aacactgaca gtaacttctt tggaatgtga agttcttatc agtacagttt ggacaggcct     2090

aaaaggcatg ggatgatgca gaaatgctga attatttttc atacttaaac tttgtgcttt     2150

ctccaaggtt taggttaatc agttcagata tgagcaaagg tatttctaaa atggctcttc     2210

tatgaaaagc aatagtcaca tatgccaagg ccaatgtttc cttcaaggtg ccagtagaaa     2270

caacagaaaa taacatcctg ctgaaaggat ggcaaagtgc cccgccccac cccacaaaca     2330

caatttggat cttttccttc tttaataaag cagggctgta ttatcttgaa tatatgtttg     2390

cttgttagaa catattaaga tatatttatt tgccactagt atttaacatt ttgtgcacat     2450

tttcataatt acattcttac ctttcaaatt ttgactcaaa gtggataggc tagtgttgat     2510

attggagtgc aaatgtatat actccaagag ctagttctta attctgctga gttggaaagc     2570

cttttattat tgtctgtatc cttactggtt ttatctagtt caaaaaaggt gacaacgtct     2630

aaattttgat gtggacctct ctccatagag agccgctcct aagtgcaaga aattccaaca     2690

ggtgtcagta ggacttggcc ctgggggaca acaagtggca ggaacaggat cctttaaaac     2750

agtgtcaaac ttctcatgca tggagcatga attcttacta atagagactg tagttttttt     2810

cttgtctttg gtaaatatat aaaagacctt aatttttctt ttttaatgaa tggagaaaac     2870

atgagaaaac cagatggacc tgttagtact acatttttaa ggcattttat atttgatggt     2930

gccgtacttt taataataat aaaactgaag ttttttagtg gcaatactga tttatttttt     2990

aaaccagaaa gataatccat attgattact tactacaaaa aagggaaaat atgccaaaaa     3050

ataaaaaacc ttaaaattca tatgaagcaa cgtaacagat aactgagcac ttggctcaag     3110

tggtcagact tttcataatg ttactgtgta agtttggaat tacctaataa ccccaggctc     3170

aggattaaca gaaggttctg ggtgagtttt aaaacattta atatacctat gatttgtttt     3230

acaacttgaa gaaaaggcag gcagtcttgt gtctaatgag cttaatgcaa attctaatta     3290

tactgcaaat aatttaaagt tttgattgca ttctacaatt gtctgtttgg aaaattacat     3350

attatgaagt cattatatat tttatcaaat cagaaaaagt cagctcagga actgtagcag     3410

cagggagttc taaagatgac atgaactata ctataggggt gccctactct atatggccta     3470

gggctttggt ttgggtcagt cttgttcttt cagatacata acaccagcag tactttcggg     3530

ctcacttcaa gaaccagata actctcccaa accatgatac atgaagtgta taatcaagat     3590

ttttaattaa gctttagaat tctttatttg tgtagagtga tggaaatgac caagaagtaa     3650

taatataaag caaaagaatt gggagagatc aggttttaag tatataaata tttttttttt     3710

ctcatggcat attctcaaag gtgttttgtt acaaaccaga ttttcatttt ttaaaaaatg     3770

agacttggtg gtatttaaaa cctacaccta ccatgttgct atttcacttt cattgcttta     3830

gttgcttaat atttaagctt tgcttcatgc taccttttgt ctgtatttca atcttcataa     3890

gcctattttg ttttgtagac ttgaatgata aaaattgttt ctcatcttaa gtatgctcag     3950

agttttaaat gttaaagaat gttgtgtaac ctttatccaa taaagtcttt gattttttaa     4010

aaaaaa                                                                4016


<210>  96
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Ala Val Ala Ala Glu Ala Ala Ala Thr Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Gly Gly Ala Gly Glu Ala Glu Pro Glu Met Glu Pro Ile Pro Gly 
            20                  25                  30          


Ser Glu Ala Gly Thr Asp Pro Leu Pro Val Thr Ala Thr Glu Ala Ser 
        35                  40                  45              


Val Pro Asp Gly Glu Thr Asp Gly Gln Gln Ser Ala Pro Gln Ala Asp 
    50                  55                  60                  


Glu Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Gly Glu Leu Ala Arg 
65                  70                  75                  80  


Ser Pro Glu Ala Val Gly Pro Glu Leu Glu Ala Glu Glu Lys Leu Ser 
                85                  90                  95      


Val Arg Val Ala Glu Ser Ala Ala Ala Ala Pro Gln Gly Gly Pro Glu 
            100                 105                 110         


Leu Pro Pro Ser Pro Ala Ser Pro Pro Glu Gln Pro Pro Ala Pro Glu 
        115                 120                 125             


Glu Arg Glu Glu Pro Pro Leu Pro Gln Pro Val Ala Pro Ala Leu Val 
    130                 135                 140                 


Pro Pro Ala Gly Gly Asp Ser Thr Val Ser Gln Leu Ile Pro Gly Ser 
145                 150                 155                 160 


Glu Val Arg Val Thr Leu Asp His Ile Ile Glu Asp Ala Leu Val Val 
                165                 170                 175     


Ser Phe Arg Phe Gly Glu Lys Leu Phe Ser Gly Val Leu Met Asp Leu 
            180                 185                 190         


Ser Lys Arg Phe Gly Pro His Gly Ile Pro Val Thr Val Phe Pro Lys 
        195                 200                 205             


Arg Glu Tyr Lys Asp Lys Pro Glu Ala Met Pro Leu Gln Ser Asn Thr 
    210                 215                 220                 


Phe Gln Glu Gly Thr Glu Val Lys Cys Glu Ala Asn Gly Ala Val Pro 
225                 230                 235                 240 


Asp Asp Pro Ser Pro Val Pro His Pro Glu Leu Ser Leu Ala Glu Ser 
                245                 250                 255     


Leu Trp Thr Ser Lys Pro Pro Pro Leu Phe His Glu Gly Ala Pro Tyr 
            260                 265                 270         


Pro Pro Pro Leu Phe Ile Arg Asp Thr Tyr Asn Gln Ser Ile Pro Gln 
        275                 280                 285             


Pro Pro Pro Arg Lys Ile Lys Arg Pro Lys Arg Lys Met Tyr Arg Glu 
    290                 295                 300                 


Glu Pro Thr Ser Ile Met Asn Ala Ile Lys Leu Arg Pro Arg Gln Val 
305                 310                 315                 320 


Leu Cys Asp Lys Cys Lys Asn Ser Val Val Ala Glu Lys Lys Glu Ile 
                325                 330                 335     


Arg Lys Gly Ser Ser Ala Thr Asp Ser Ser Lys Tyr Glu Asp Lys Lys 
            340                 345                 350         


Arg Arg Asn Glu Ser Val Thr Thr Val Asn Lys Lys Leu Lys Thr Asp 
        355                 360                 365             


His Lys Val Asp Gly Lys Asn Gln Asn Glu Ser Gln Lys Arg Asn Ala 
    370                 375                 380                 


Val Val Lys Val Ser Asn Ile Ala His Ser Arg Gly Arg Val Val Lys 
385                 390                 395                 400 


Val Ser Ala Gln Ala Asn Thr Ser Lys Ala Gln Leu Ser Thr Lys Lys 
                405                 410                 415     


Val Leu Gln Ser Lys Asn Met Asp His Ala Lys Ala Arg Glu Val Leu 
            420                 425                 430         


Lys Ile Ala Lys Glu Lys Ala Gln Lys Lys Gln Asn Glu Thr Ser Thr 
        435                 440                 445             


Ser Lys Asn Ala His Ser Lys Val His Phe Thr Arg Arg Tyr Gln Asn 
    450                 455                 460                 


Pro Ser Ser Gly Ser Leu Pro Pro Arg Val Arg Leu Lys Pro Gln Arg 
465                 470                 475                 480 


Tyr Arg Asn Glu Glu Asn Asp Ser Ser Leu Lys Thr Gly Leu Glu Lys 
                485                 490                 495     


Met Arg Ser Gly Lys Met Ala Pro Lys Pro Gln Ser Arg Cys Thr Ser 
            500                 505                 510         


Thr Arg Ser Ala Gly Leu Asn Lys Trp Gln Leu Leu His Gln Thr Val 
        515                 520                 525             


Thr Ser Pro Ala Ala Pro Leu Gln Cys Leu Thr Asp His Cys Gly Phe 
    530                 535                 540                 


Arg Leu Gly Ala Leu Lys Leu Thr Val Lys Arg Ala Ala Gln Arg His 
545                 550                 555                 560 


<210>  97
<211>  3059
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (224)..(2722)

<400>  97
tcctctgcgt cccgccccgg gagtggctgc gaggctaggc gagccgggaa agggggcgcc       60

gcccagcccc gagccccgcg ccccgtgccc cgagcccgga gccccctgcc cgccgcggca      120

ccatgcgcgc cgagccggcg tgaccggctc cgcccgcggc cgccccgcag ctagcccggc      180

gctctcgccg gccacacgga gcggcgcccg ggagctatga gcc atg aag ccg ccc        235
                                                Met Lys Pro Pro           
                                                1                         

ggc agc agc tcg cgg cag ccg ccc ctg gcg ggc tgc agc ctt gcc ggc        283
Gly Ser Ser Ser Arg Gln Pro Pro Leu Ala Gly Cys Ser Leu Ala Gly           
5                   10                  15                  20            

gct tcc tgc ggc ccc caa cgc ggc ccc gcc ggc tcg gtg cct gcc agc        331
Ala Ser Cys Gly Pro Gln Arg Gly Pro Ala Gly Ser Val Pro Ala Ser           
                25                  30                  35                

gcc ccg gcc cgc acg ccg ccc tgc cgc ctg ctt ctc gtc ctt ctc ctg        379
Ala Pro Ala Arg Thr Pro Pro Cys Arg Leu Leu Leu Val Leu Leu Leu           
            40                  45                  50                    

ctg cct ccg ctc gcc gcc tcg tcc cgg ccc cgc gcc tgg ggg gct gct        427
Leu Pro Pro Leu Ala Ala Ser Ser Arg Pro Arg Ala Trp Gly Ala Ala           
        55                  60                  65                        

gcg ccc agc gct ccg cat tgg aat gaa act gca gaa aaa aat ttg gga        475
Ala Pro Ser Ala Pro His Trp Asn Glu Thr Ala Glu Lys Asn Leu Gly           
    70                  75                  80                            

gtc ctg gca gat gaa gac aat aca ttg caa cag aat agc agc agt aat        523
Val Leu Ala Asp Glu Asp Asn Thr Leu Gln Gln Asn Ser Ser Ser Asn           
85                  90                  95                  100           

atc agt tac agc aat gca atg cag aaa gaa atc aca ctg cct tca aga        571
Ile Ser Tyr Ser Asn Ala Met Gln Lys Glu Ile Thr Leu Pro Ser Arg           
                105                 110                 115               

ctc ata tat tac atc aac caa gac tcg gaa agc cct tat cac gtt ctt        619
Leu Ile Tyr Tyr Ile Asn Gln Asp Ser Glu Ser Pro Tyr His Val Leu           
            120                 125                 130                   

gac aca aag gca aga cac cag caa aaa cat aat aag gct gtc cat ctg        667
Asp Thr Lys Ala Arg His Gln Gln Lys His Asn Lys Ala Val His Leu           
        135                 140                 145                       

gcc cag gca agc ttc cag att gaa gcc ttc ggc tcc aaa ttc att ctt        715
Ala Gln Ala Ser Phe Gln Ile Glu Ala Phe Gly Ser Lys Phe Ile Leu           
    150                 155                 160                           

gac ctc ata ctg aac aat ggt ttg ttg tct tct gat tat gtg gag att        763
Asp Leu Ile Leu Asn Asn Gly Leu Leu Ser Ser Asp Tyr Val Glu Ile           
165                 170                 175                 180           

cac tac gaa aat ggg aaa cca cag tac tct aag ggt gga gag cac tgt        811
His Tyr Glu Asn Gly Lys Pro Gln Tyr Ser Lys Gly Gly Glu His Cys           
                185                 190                 195               

tac tac cat gga agc atc aga ggc gtc aaa gac tcc aag gtg gct ctg        859
Tyr Tyr His Gly Ser Ile Arg Gly Val Lys Asp Ser Lys Val Ala Leu           
            200                 205                 210                   

tca acc tgc aat gga ctt cat ggc atg ttt gaa gat gat acc ttc gtg        907
Ser Thr Cys Asn Gly Leu His Gly Met Phe Glu Asp Asp Thr Phe Val           
        215                 220                 225                       

tat atg ata gag cca cta gag ctg gtt cat gat gag aaa agc aca ggt        955
Tyr Met Ile Glu Pro Leu Glu Leu Val His Asp Glu Lys Ser Thr Gly           
    230                 235                 240                           

cga cca cat ata atc cag aaa acc ttg gca gga cag tat tct aag caa       1003
Arg Pro His Ile Ile Gln Lys Thr Leu Ala Gly Gln Tyr Ser Lys Gln           
245                 250                 255                 260           

atg aag aat ctc act atg gaa aga ggt gac cag tgg ccc ttt ctc tct       1051
Met Lys Asn Leu Thr Met Glu Arg Gly Asp Gln Trp Pro Phe Leu Ser           
                265                 270                 275               

gaa tta cag tgg ttg aaa aga agg aag aga gca gtg aat cca tca cgt       1099
Glu Leu Gln Trp Leu Lys Arg Arg Lys Arg Ala Val Asn Pro Ser Arg           
            280                 285                 290                   

ggt ata ttt gaa gaa atg aaa tat ttg gaa ctt atg att gtt aat gat       1147
Gly Ile Phe Glu Glu Met Lys Tyr Leu Glu Leu Met Ile Val Asn Asp           
        295                 300                 305                       

cac aaa acg tat aag aag cat cgc tct tct cat gca cat acc aac aac       1195
His Lys Thr Tyr Lys Lys His Arg Ser Ser His Ala His Thr Asn Asn           
    310                 315                 320                           

ttt gca aag tcc gtg gtc aac ctt gtg gat tct att tac aag gag cag       1243
Phe Ala Lys Ser Val Val Asn Leu Val Asp Ser Ile Tyr Lys Glu Gln           
325                 330                 335                 340           

ctc aac acc agg gtt gtc ctg gtg gct gta gag acc tgg act gag aag       1291
Leu Asn Thr Arg Val Val Leu Val Ala Val Glu Thr Trp Thr Glu Lys           
                345                 350                 355               

gat cag att gac atc acc acc aac cct gtg cag atg ctc cat gag ttc       1339
Asp Gln Ile Asp Ile Thr Thr Asn Pro Val Gln Met Leu His Glu Phe           
            360                 365                 370                   

tca aaa tac cgg cag cgc att aag cag cat gct gat gct gtg cac ctc       1387
Ser Lys Tyr Arg Gln Arg Ile Lys Gln His Ala Asp Ala Val His Leu           
        375                 380                 385                       

atc tcg cgg gtg aca ttt cac tat aag aga agc agt ctg agt tac ttt       1435
Ile Ser Arg Val Thr Phe His Tyr Lys Arg Ser Ser Leu Ser Tyr Phe           
    390                 395                 400                           

gga ggt gtc tgt tct cgc aca aga gga gtt ggt gtg aat gag tat ggt       1483
Gly Gly Val Cys Ser Arg Thr Arg Gly Val Gly Val Asn Glu Tyr Gly           
405                 410                 415                 420           

ctt cca atg gca gtg gca caa gta tta tcg cag agc ctg gct caa aac       1531
Leu Pro Met Ala Val Ala Gln Val Leu Ser Gln Ser Leu Ala Gln Asn           
                425                 430                 435               

ctt gga atc caa tgg gaa cct tct agc aga aag cca aaa tgt gac tgc       1579
Leu Gly Ile Gln Trp Glu Pro Ser Ser Arg Lys Pro Lys Cys Asp Cys           
            440                 445                 450                   

aca gaa tcc tgg ggt ggc tgc atc atg gag gaa aca ggg gtg tcc cat       1627
Thr Glu Ser Trp Gly Gly Cys Ile Met Glu Glu Thr Gly Val Ser His           
        455                 460                 465                       

tct cga aaa ttt tca aag tgc agc att ttg gag tat aga gac ttt tta       1675
Ser Arg Lys Phe Ser Lys Cys Ser Ile Leu Glu Tyr Arg Asp Phe Leu           
    470                 475                 480                           

cag aga gga ggt gga gcc tgc ctt ttc aac agg cca aca aag cta ttt       1723
Gln Arg Gly Gly Gly Ala Cys Leu Phe Asn Arg Pro Thr Lys Leu Phe           
485                 490                 495                 500           

gag ccc acg gaa tgt gga aat gga tac gtg gaa gct ggg gag gag tgt       1771
Glu Pro Thr Glu Cys Gly Asn Gly Tyr Val Glu Ala Gly Glu Glu Cys           
                505                 510                 515               

gat tgt ggt ttt cat gtg gaa tgc tat gga tta tgc tgt aag aaa tgt       1819
Asp Cys Gly Phe His Val Glu Cys Tyr Gly Leu Cys Cys Lys Lys Cys           
            520                 525                 530                   

tcc ctc tcc aac ggg gct cac tgc agc gac ggg ccc tgc tgt aac aat       1867
Ser Leu Ser Asn Gly Ala His Cys Ser Asp Gly Pro Cys Cys Asn Asn           
        535                 540                 545                       

acc tca tgt ctt ttt cag cca cga ggg tat gaa tgc cgg gat gct gtg       1915
Thr Ser Cys Leu Phe Gln Pro Arg Gly Tyr Glu Cys Arg Asp Ala Val           
    550                 555                 560                           

aac gag tgt gat att act gaa tat tgt act gga gac tct ggt cag tgc       1963
Asn Glu Cys Asp Ile Thr Glu Tyr Cys Thr Gly Asp Ser Gly Gln Cys           
565                 570                 575                 580           

cca cca aat ctt cat aag caa gac gga tat gca tgc aat caa aat cag       2011
Pro Pro Asn Leu His Lys Gln Asp Gly Tyr Ala Cys Asn Gln Asn Gln           
                585                 590                 595               

ggc cgc tgc tac aat ggc gag tgc aag acc aga gac aac cag tgt cag       2059
Gly Arg Cys Tyr Asn Gly Glu Cys Lys Thr Arg Asp Asn Gln Cys Gln           
            600                 605                 610                   

tac atc tgg gga aca aag gct gca ggg tct gac aag ttc tgc tat gaa       2107
Tyr Ile Trp Gly Thr Lys Ala Ala Gly Ser Asp Lys Phe Cys Tyr Glu           
        615                 620                 625                       

aag ctg aat aca gaa ggc act gag aag gga aac tgc ggg aag gat gga       2155
Lys Leu Asn Thr Glu Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Gly           
    630                 635                 640                           

gac cgg tgg att cag tgc agc aaa cat gat gtg ttc tgt gga ttc tta       2203
Asp Arg Trp Ile Gln Cys Ser Lys His Asp Val Phe Cys Gly Phe Leu           
645                 650                 655                 660           

ctc tgt acc aat ctt act cga gct cca cgt att ggt caa ctt cag ggt       2251
Leu Cys Thr Asn Leu Thr Arg Ala Pro Arg Ile Gly Gln Leu Gln Gly           
                665                 670                 675               

gag atc att cca act tcc ttc tac cat caa ggc cgg gtg att gac tgc       2299
Glu Ile Ile Pro Thr Ser Phe Tyr His Gln Gly Arg Val Ile Asp Cys           
            680                 685                 690                   

agt ggt gcc cat gta gtt tta gat gat gat acg gat gtg ggc tat gta       2347
Ser Gly Ala His Val Val Leu Asp Asp Asp Thr Asp Val Gly Tyr Val           
        695                 700                 705                       

gaa gat gga acg cca tgt ggc ccg tct atg atg tgt tta gat cgg aag       2395
Glu Asp Gly Thr Pro Cys Gly Pro Ser Met Met Cys Leu Asp Arg Lys           
    710                 715                 720                           

tgc cta caa att caa gcc cta aat atg agc agc tgt cca ctc gat tcc       2443
Cys Leu Gln Ile Gln Ala Leu Asn Met Ser Ser Cys Pro Leu Asp Ser           
725                 730                 735                 740           

aag ggt aaa gtc tgt tcg ggc cat ggg gtg tgt agt aat gaa gcc acc       2491
Lys Gly Lys Val Cys Ser Gly His Gly Val Cys Ser Asn Glu Ala Thr           
                745                 750                 755               

tgc att tgt gat ttc acc tgg gca ggg aca gat tgc agt atc cgg gat       2539
Cys Ile Cys Asp Phe Thr Trp Ala Gly Thr Asp Cys Ser Ile Arg Asp           
            760                 765                 770                   

cca gtt agg aac ctt cac ccc ccc aag gat gaa gga ccc aag ggt cct       2587
Pro Val Arg Asn Leu His Pro Pro Lys Asp Glu Gly Pro Lys Gly Pro           
        775                 780                 785                       

agt gcc acc aat ctc ata ata ggc tcc atc gct ggt gcc atc ctg gta       2635
Ser Ala Thr Asn Leu Ile Ile Gly Ser Ile Ala Gly Ala Ile Leu Val           
    790                 795                 800                           

gca gct att gtc ctt ggg ggc aca ggc tgg gga ttt aaa aat gtc aag       2683
Ala Ala Ile Val Leu Gly Gly Thr Gly Trp Gly Phe Lys Asn Val Lys           
805                 810                 815                 820           

aag aga agg ttc gat cct act cag caa ggc ccc atc tga atcagctgcg        2732
Lys Arg Arg Phe Asp Pro Thr Gln Gln Gly Pro Ile                           
                825                 830                                   

ctggatggac accgccttgc actgttggat tctgggtatg acatactcgc agcagtgtta     2792

ctggaactat taagtttgta aacaaaacct ttgggtggta atgactacgg agctaaagtt     2852

ggggtgacaa ggatggggta aaagaaaact gtctcttttg gaaataatgt caaagaacac     2912

ctttcaccac ctgtcagtaa acgggggagg gggcaaaaga ccatgctata aaaagaactg     2972

ttccagaatc ttttttttcc ctaatggacg aaggaacaac acacacacaa aaattaaatg     3032

caataaagga atcattaaaa aaaaaaa                                         3059


<210>  98
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Lys Pro Pro Gly Ser Ser Ser Arg Gln Pro Pro Leu Ala Gly Cys 
1               5                   10                  15      


Ser Leu Ala Gly Ala Ser Cys Gly Pro Gln Arg Gly Pro Ala Gly Ser 
            20                  25                  30          


Val Pro Ala Ser Ala Pro Ala Arg Thr Pro Pro Cys Arg Leu Leu Leu 
        35                  40                  45              


Val Leu Leu Leu Leu Pro Pro Leu Ala Ala Ser Ser Arg Pro Arg Ala 
    50                  55                  60                  


Trp Gly Ala Ala Ala Pro Ser Ala Pro His Trp Asn Glu Thr Ala Glu 
65                  70                  75                  80  


Lys Asn Leu Gly Val Leu Ala Asp Glu Asp Asn Thr Leu Gln Gln Asn 
                85                  90                  95      


Ser Ser Ser Asn Ile Ser Tyr Ser Asn Ala Met Gln Lys Glu Ile Thr 
            100                 105                 110         


Leu Pro Ser Arg Leu Ile Tyr Tyr Ile Asn Gln Asp Ser Glu Ser Pro 
        115                 120                 125             


Tyr His Val Leu Asp Thr Lys Ala Arg His Gln Gln Lys His Asn Lys 
    130                 135                 140                 


Ala Val His Leu Ala Gln Ala Ser Phe Gln Ile Glu Ala Phe Gly Ser 
145                 150                 155                 160 


Lys Phe Ile Leu Asp Leu Ile Leu Asn Asn Gly Leu Leu Ser Ser Asp 
                165                 170                 175     


Tyr Val Glu Ile His Tyr Glu Asn Gly Lys Pro Gln Tyr Ser Lys Gly 
            180                 185                 190         


Gly Glu His Cys Tyr Tyr His Gly Ser Ile Arg Gly Val Lys Asp Ser 
        195                 200                 205             


Lys Val Ala Leu Ser Thr Cys Asn Gly Leu His Gly Met Phe Glu Asp 
    210                 215                 220                 


Asp Thr Phe Val Tyr Met Ile Glu Pro Leu Glu Leu Val His Asp Glu 
225                 230                 235                 240 


Lys Ser Thr Gly Arg Pro His Ile Ile Gln Lys Thr Leu Ala Gly Gln 
                245                 250                 255     


Tyr Ser Lys Gln Met Lys Asn Leu Thr Met Glu Arg Gly Asp Gln Trp 
            260                 265                 270         


Pro Phe Leu Ser Glu Leu Gln Trp Leu Lys Arg Arg Lys Arg Ala Val 
        275                 280                 285             


Asn Pro Ser Arg Gly Ile Phe Glu Glu Met Lys Tyr Leu Glu Leu Met 
    290                 295                 300                 


Ile Val Asn Asp His Lys Thr Tyr Lys Lys His Arg Ser Ser His Ala 
305                 310                 315                 320 


His Thr Asn Asn Phe Ala Lys Ser Val Val Asn Leu Val Asp Ser Ile 
                325                 330                 335     


Tyr Lys Glu Gln Leu Asn Thr Arg Val Val Leu Val Ala Val Glu Thr 
            340                 345                 350         


Trp Thr Glu Lys Asp Gln Ile Asp Ile Thr Thr Asn Pro Val Gln Met 
        355                 360                 365             


Leu His Glu Phe Ser Lys Tyr Arg Gln Arg Ile Lys Gln His Ala Asp 
    370                 375                 380                 


Ala Val His Leu Ile Ser Arg Val Thr Phe His Tyr Lys Arg Ser Ser 
385                 390                 395                 400 


Leu Ser Tyr Phe Gly Gly Val Cys Ser Arg Thr Arg Gly Val Gly Val 
                405                 410                 415     


Asn Glu Tyr Gly Leu Pro Met Ala Val Ala Gln Val Leu Ser Gln Ser 
            420                 425                 430         


Leu Ala Gln Asn Leu Gly Ile Gln Trp Glu Pro Ser Ser Arg Lys Pro 
        435                 440                 445             


Lys Cys Asp Cys Thr Glu Ser Trp Gly Gly Cys Ile Met Glu Glu Thr 
    450                 455                 460                 


Gly Val Ser His Ser Arg Lys Phe Ser Lys Cys Ser Ile Leu Glu Tyr 
465                 470                 475                 480 


Arg Asp Phe Leu Gln Arg Gly Gly Gly Ala Cys Leu Phe Asn Arg Pro 
                485                 490                 495     


Thr Lys Leu Phe Glu Pro Thr Glu Cys Gly Asn Gly Tyr Val Glu Ala 
            500                 505                 510         


Gly Glu Glu Cys Asp Cys Gly Phe His Val Glu Cys Tyr Gly Leu Cys 
        515                 520                 525             


Cys Lys Lys Cys Ser Leu Ser Asn Gly Ala His Cys Ser Asp Gly Pro 
    530                 535                 540                 


Cys Cys Asn Asn Thr Ser Cys Leu Phe Gln Pro Arg Gly Tyr Glu Cys 
545                 550                 555                 560 


Arg Asp Ala Val Asn Glu Cys Asp Ile Thr Glu Tyr Cys Thr Gly Asp 
                565                 570                 575     


Ser Gly Gln Cys Pro Pro Asn Leu His Lys Gln Asp Gly Tyr Ala Cys 
            580                 585                 590         


Asn Gln Asn Gln Gly Arg Cys Tyr Asn Gly Glu Cys Lys Thr Arg Asp 
        595                 600                 605             


Asn Gln Cys Gln Tyr Ile Trp Gly Thr Lys Ala Ala Gly Ser Asp Lys 
    610                 615                 620                 


Phe Cys Tyr Glu Lys Leu Asn Thr Glu Gly Thr Glu Lys Gly Asn Cys 
625                 630                 635                 640 


Gly Lys Asp Gly Asp Arg Trp Ile Gln Cys Ser Lys His Asp Val Phe 
                645                 650                 655     


Cys Gly Phe Leu Leu Cys Thr Asn Leu Thr Arg Ala Pro Arg Ile Gly 
            660                 665                 670         


Gln Leu Gln Gly Glu Ile Ile Pro Thr Ser Phe Tyr His Gln Gly Arg 
        675                 680                 685             


Val Ile Asp Cys Ser Gly Ala His Val Val Leu Asp Asp Asp Thr Asp 
    690                 695                 700                 


Val Gly Tyr Val Glu Asp Gly Thr Pro Cys Gly Pro Ser Met Met Cys 
705                 710                 715                 720 


Leu Asp Arg Lys Cys Leu Gln Ile Gln Ala Leu Asn Met Ser Ser Cys 
                725                 730                 735     


Pro Leu Asp Ser Lys Gly Lys Val Cys Ser Gly His Gly Val Cys Ser 
            740                 745                 750         


Asn Glu Ala Thr Cys Ile Cys Asp Phe Thr Trp Ala Gly Thr Asp Cys 
        755                 760                 765             


Ser Ile Arg Asp Pro Val Arg Asn Leu His Pro Pro Lys Asp Glu Gly 
    770                 775                 780                 


Pro Lys Gly Pro Ser Ala Thr Asn Leu Ile Ile Gly Ser Ile Ala Gly 
785                 790                 795                 800 


Ala Ile Leu Val Ala Ala Ile Val Leu Gly Gly Thr Gly Trp Gly Phe 
                805                 810                 815     


Lys Asn Val Lys Lys Arg Arg Phe Asp Pro Thr Gln Gln Gly Pro Ile 
            820                 825                 830         


<210>  99
<211>  951
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(951)

<400>  99
atg aag ata gca aac aac aca gta gtg aca gaa ttt atc ctc ctt ggt         48
Met Lys Ile Ala Asn Asn Thr Val Val Thr Glu Phe Ile Leu Leu Gly           
1               5                   10                  15                

ctg act cag tct caa gat att cag ctc ttg gtc ttt gtg ctg atc tta         96
Leu Thr Gln Ser Gln Asp Ile Gln Leu Leu Val Phe Val Leu Ile Leu           
            20                  25                  30                    

att ttc tac ctt atc atc ctc cct gga aat ttt ctc att att ttc acc        144
Ile Phe Tyr Leu Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr           
        35                  40                  45                        

ata agg tca gac cct ggg ctc aca gcc ccc ctc tat ttc ttt ctg ggc        192
Ile Arg Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly           
    50                  55                  60                            

aac ttg gcc ttc ctg gat gca tcc tac tcc ttc att gtg gct ccc agg        240
Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Ile Val Ala Pro Arg           
65                  70                  75                  80            

atg ttg gtg gac ttc ttc tct gag aag aag gta atc tcc tac aga ggc        288
Met Leu Val Asp Phe Phe Ser Glu Lys Lys Val Ile Ser Tyr Arg Gly           
                85                  90                  95                

tgc atc act cag ctc ttt ttc ttg cac ttc ctt gga gga ggg gag gga        336
Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly           
            100                 105                 110                   

tta ctc ctt gtt gtg atg gcc ttt gac cgc tac atc gcc atc tgc cgg        384
Leu Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg           
        115                 120                 125                       

cct ctg cac tgt tca act gtc atg aac cct aga gcc tgc tat gca atg        432
Pro Leu His Cys Ser Thr Val Met Asn Pro Arg Ala Cys Tyr Ala Met           
    130                 135                 140                           

atg ttg gct ctg tgg ctt ggg ggt ttt gtc cac tcc att atc cag gtg        480
Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val           
145                 150                 155                 160           

gtc ctc atc ctc cgc ttg cct ttt tgt ggc cca aac cag ctg gac aac        528
Val Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn           
                165                 170                 175               

ttc ttc tgt gat gtc cga cag gtc atc aag ctg gct tgc acc gac atg        576
Phe Phe Cys Asp Val Arg Gln Val Ile Lys Leu Ala Cys Thr Asp Met           
            180                 185                 190                   

ttt gtg gtg gag ctt ctg atg gtc ttc aac agt ggc ctg atg aca ctc        624
Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu           
        195                 200                 205                       

ctg tgc ttt ctg ggg ctt ctg gct tcc tat gca gtc atc ctc tgc cat        672
Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys His           
    210                 215                 220                           

gtt cgt agg gca gct tct gaa ggg aag aac aag gcc atg tcc atg tgc        720
Val Arg Arg Ala Ala Ser Glu Gly Lys Asn Lys Ala Met Ser Met Cys           
225                 230                 235                 240           

acc act cgt gtc att att ata ctt ctt atg ttt gga cct gct atc ttc        768
Thr Thr Arg Val Ile Ile Ile Leu Leu Met Phe Gly Pro Ala Ile Phe           
                245                 250                 255               

atc tac atg tgc cct ttc agg gcc tta cca gct gac aag atg gtt tct        816
Ile Tyr Met Cys Pro Phe Arg Ala Leu Pro Ala Asp Lys Met Val Ser           
            260                 265                 270                   

ctc ttt cac aca gtg atc ttt cca ttg atg aat cct atg att tat acc        864
Leu Phe His Thr Val Ile Phe Pro Leu Met Asn Pro Met Ile Tyr Thr           
        275                 280                 285                       

ctt cgc aac cag gaa gtg aaa act tcc atg aag agg tta ttg agt cga        912
Leu Arg Asn Gln Glu Val Lys Thr Ser Met Lys Arg Leu Leu Ser Arg           
    290                 295                 300                           

cat gta gtc tgt caa gtg gat ttt ata ata aga aac tga                    951
His Val Val Cys Gln Val Asp Phe Ile Ile Arg Asn                           
305                 310                 315                               


<210>  100
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Lys Ile Ala Asn Asn Thr Val Val Thr Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Leu Thr Gln Ser Gln Asp Ile Gln Leu Leu Val Phe Val Leu Ile Leu 
            20                  25                  30          


Ile Phe Tyr Leu Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr 
        35                  40                  45              


Ile Arg Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Ile Val Ala Pro Arg 
65                  70                  75                  80  


Met Leu Val Asp Phe Phe Ser Glu Lys Lys Val Ile Ser Tyr Arg Gly 
                85                  90                  95      


Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly 
            100                 105                 110         


Leu Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg 
        115                 120                 125             


Pro Leu His Cys Ser Thr Val Met Asn Pro Arg Ala Cys Tyr Ala Met 
    130                 135                 140                 


Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val 
145                 150                 155                 160 


Val Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn 
                165                 170                 175     


Phe Phe Cys Asp Val Arg Gln Val Ile Lys Leu Ala Cys Thr Asp Met 
            180                 185                 190         


Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu 
        195                 200                 205             


Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys His 
    210                 215                 220                 


Val Arg Arg Ala Ala Ser Glu Gly Lys Asn Lys Ala Met Ser Met Cys 
225                 230                 235                 240 


Thr Thr Arg Val Ile Ile Ile Leu Leu Met Phe Gly Pro Ala Ile Phe 
                245                 250                 255     


Ile Tyr Met Cys Pro Phe Arg Ala Leu Pro Ala Asp Lys Met Val Ser 
            260                 265                 270         


Leu Phe His Thr Val Ile Phe Pro Leu Met Asn Pro Met Ile Tyr Thr 
        275                 280                 285             


Leu Arg Asn Gln Glu Val Lys Thr Ser Met Lys Arg Leu Leu Ser Arg 
    290                 295                 300                 


His Val Val Cys Gln Val Asp Phe Ile Ile Arg Asn 
305                 310                 315     


<210>  101
<211>  2752
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (29)..(1921)

<400>  101
cgctaaggcc gccctccggg tagccgcc atg tcg gtc tcc agc ggc gtc cag          52
                               Met Ser Val Ser Ser Gly Val Gln            
                               1               5                          

att ctg aca aag cca gag acc gtg gac cgg agg aga agt gcg gaa acg        100
Ile Leu Thr Lys Pro Glu Thr Val Asp Arg Arg Arg Ser Ala Glu Thr           
    10                  15                  20                            

acc aaa gag gcc ggg cga cca ctg gag atg gct gtg tcc gag ccc gag        148
Thr Lys Glu Ala Gly Arg Pro Leu Glu Met Ala Val Ser Glu Pro Glu           
25                  30                  35                  40            

gcc agc gcc gcg gaa tgg aag caa ctg gat cct gct cag agc aac ctg        196
Ala Ser Ala Ala Glu Trp Lys Gln Leu Asp Pro Ala Gln Ser Asn Leu           
                45                  50                  55                

tat aat gat gtg atg ctg gag aac tac tgc aac caa gcc tca atg ggg        244
Tyr Asn Asp Val Met Leu Glu Asn Tyr Cys Asn Gln Ala Ser Met Gly           
            60                  65                  70                    

tgt caa gct ccc aaa cca gac atg atc tcc aag ttg gaa aaa gga gaa        292
Cys Gln Ala Pro Lys Pro Asp Met Ile Ser Lys Leu Glu Lys Gly Glu           
        75                  80                  85                        

gca cca tgg ttg ggg aag ggg aaa aga ccc agt caa ggt tgt cca agt        340
Ala Pro Trp Leu Gly Lys Gly Lys Arg Pro Ser Gln Gly Cys Pro Ser           
    90                  95                  100                           

aaa ata gca aga ccc aag caa aaa gaa act gat gga aaa gtc cag aaa        388
Lys Ile Ala Arg Pro Lys Gln Lys Glu Thr Asp Gly Lys Val Gln Lys           
105                 110                 115                 120           

gat gat gac cag ctt gaa aat atc cag aaa tct caa aac aaa ctc ctc        436
Asp Asp Asp Gln Leu Glu Asn Ile Gln Lys Ser Gln Asn Lys Leu Leu           
                125                 130                 135               

agg gaa gtt gca gtc aag aag aaa act caa gct aag aag aat ggc agt        484
Arg Glu Val Ala Val Lys Lys Lys Thr Gln Ala Lys Lys Asn Gly Ser           
            140                 145                 150                   

gac tgt ggt tca ctg ggg aaa aaa aat aat ttg cat aaa aaa cat gtt        532
Asp Cys Gly Ser Leu Gly Lys Lys Asn Asn Leu His Lys Lys His Val           
        155                 160                 165                       

cct tca aag aaa agg ctt ctt aaa ttt gag tca tgt gga aaa att ttg        580
Pro Ser Lys Lys Arg Leu Leu Lys Phe Glu Ser Cys Gly Lys Ile Leu           
    170                 175                 180                           

aaa cag aat tta gat tta cct gat cac tca aga aac tgt gta aaa agg        628
Lys Gln Asn Leu Asp Leu Pro Asp His Ser Arg Asn Cys Val Lys Arg           
185                 190                 195                 200           

aaa tct gat gca gct aaa gaa cac aag aag tca ttc aac cat agc tta        676
Lys Ser Asp Ala Ala Lys Glu His Lys Lys Ser Phe Asn His Ser Leu           
                205                 210                 215               

tct gat aca agg aaa ggc aaa aag caa act gga aag aaa cat gag aaa        724
Ser Asp Thr Arg Lys Gly Lys Lys Gln Thr Gly Lys Lys His Glu Lys           
            220                 225                 230                   

tta tcc agc cat agc tca tct gat aag tgt aac aaa act ggc aaa aaa        772
Leu Ser Ser His Ser Ser Ser Asp Lys Cys Asn Lys Thr Gly Lys Lys           
        235                 240                 245                       

cat gac aaa tta tgc tgt cat agt tca tcc cat att aaa cag gac aaa        820
His Asp Lys Leu Cys Cys His Ser Ser Ser His Ile Lys Gln Asp Lys           
    250                 255                 260                           

att caa act gga gag aaa cat gag aaa tca ccc agc ctt agc tca tct        868
Ile Gln Thr Gly Glu Lys His Glu Lys Ser Pro Ser Leu Ser Ser Ser           
265                 270                 275                 280           

act aag cat gaa aaa cct caa gct tgt gtg aaa ccc tat gaa tgt aat        916
Thr Lys His Glu Lys Pro Gln Ala Cys Val Lys Pro Tyr Glu Cys Asn           
                285                 290                 295               

caa tgt gga aag gtt ctc agc cat aaa caa gga ctc att gac cat cag        964
Gln Cys Gly Lys Val Leu Ser His Lys Gln Gly Leu Ile Asp His Gln           
            300                 305                 310                   

aga gtt cat act ggg gag aaa cca tat gaa tgt aat gaa tgt ggg ata       1012
Arg Val His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Ile           
        315                 320                 325                       

gcc ttt agc caa aag tca cac ctt gtt gta cat cag aga act cac acc       1060
Ala Phe Ser Gln Lys Ser His Leu Val Val His Gln Arg Thr His Thr           
    330                 335                 340                           

gga gaa aaa cca tat gaa tgt att cag tgt ggc aaa gcc cat ggt cat       1108
Gly Glu Lys Pro Tyr Glu Cys Ile Gln Cys Gly Lys Ala His Gly His           
345                 350                 355                 360           

aaa cat gca ctc act gac cat cta aga att cat act gga gaa aag ccc       1156
Lys His Ala Leu Thr Asp His Leu Arg Ile His Thr Gly Glu Lys Pro           
                365                 370                 375               

tat gaa tgt gct gaa tgt ggg aaa acc ttc aga cac agc tca aac ctt       1204
Tyr Glu Cys Ala Glu Cys Gly Lys Thr Phe Arg His Ser Ser Asn Leu           
            380                 385                 390                   

att caa cat gtg aga tct cac aca ggt gag aag cca tat gaa tgt aag       1252
Ile Gln His Val Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Lys           
        395                 400                 405                       

gaa tgt ggg aag tct ttt agg tat aac tca tct ctt acc gaa cat gtg       1300
Glu Cys Gly Lys Ser Phe Arg Tyr Asn Ser Ser Leu Thr Glu His Val           
    410                 415                 420                           

aga aca cat aca ggt gaa ata cca tat gaa tgc aat gaa tgt gga aaa       1348
Arg Thr His Thr Gly Glu Ile Pro Tyr Glu Cys Asn Glu Cys Gly Lys           
425                 430                 435                 440           

gcc ttt aag tat agc tca tcc ctt act aaa cac atg aga att cat aca       1396
Ala Phe Lys Tyr Ser Ser Ser Leu Thr Lys His Met Arg Ile His Thr           
                445                 450                 455               

ggt gag aaa ccc ttt gaa tgt aat gaa tgt ggg aaa gct ttc agc aag       1444
Gly Glu Lys Pro Phe Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser Lys           
            460                 465                 470                   

aag tca cac ctc att ata cat caa aga act cat act aag gag aaa cct       1492
Lys Ser His Leu Ile Ile His Gln Arg Thr His Thr Lys Glu Lys Pro           
        475                 480                 485                       

tat aaa tgt aat gag tgt gga aaa gcc ttt gga cat agc tca tct ctt       1540
Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Gly His Ser Ser Ser Leu           
    490                 495                 500                           

act tac cat atg aga act cat aca ggt gaa agt ccc ttt gaa tgt aat       1588
Thr Tyr His Met Arg Thr His Thr Gly Glu Ser Pro Phe Glu Cys Asn           
505                 510                 515                 520           

caa tgt ggg aaa ggc ttt aaa caa att gaa ggc ctt act caa cat cag       1636
Gln Cys Gly Lys Gly Phe Lys Gln Ile Glu Gly Leu Thr Gln His Gln           
                525                 530                 535               

aga gtt cat act gga gag aaa ccg tat gag tgt aat gaa tgt ggg aaa       1684
Arg Val His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys           
            540                 545                 550                   

gcc ttt agc caa aag tct cac ctc att gta cat cag aga act cat act       1732
Ala Phe Ser Gln Lys Ser His Leu Ile Val His Gln Arg Thr His Thr           
        555                 560                 565                       

ggg gag aaa cct tat gaa tgt aac gaa tgt gaa aaa gcc ttt aat gca       1780
Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Glu Lys Ala Phe Asn Ala           
    570                 575                 580                           

aaa tca cag ctt gtt ata cat cag cga tcc cac act gga gaa aaa ccc       1828
Lys Ser Gln Leu Val Ile His Gln Arg Ser His Thr Gly Glu Lys Pro           
585                 590                 595                 600           

tat gaa tgt aat gaa tgt ggg aaa act ttc aaa caa aat gca tcc cta       1876
Tyr Glu Cys Asn Glu Cys Gly Lys Thr Phe Lys Gln Asn Ala Ser Leu           
                605                 610                 615               

acc aaa cat gtg aaa act cat tca gaa gat aaa tct cat gag tga           1921
Thr Lys His Val Lys Thr His Ser Glu Asp Lys Ser His Glu                   
            620                 625                 630                   

agttaatgtg ggaaatttgt taactaaatt taaggttttg ttgaaccttg gaaatatgct     1981

gattttaaag agtgttagaa agcctttagc aagatgtcac accttgttgt acatgagaaa     2041

ctttgaaaat ggatcttcat atagaatcag tggatggaaa caagggttta aacttgatac     2101

aaaacctttt ataaaaaata ttgttttaac tactcaatta ttataaatga tctacatgtt     2161

cagattgaaa ttgaaagctt taaaaattgt gaattatttg aatattcaaa gcaatggaga     2221

aacaagttat atatgctgac agttcctgtg tttcttcttg ttttgtactt aagcaccata     2281

tattagagtt gaatttgcat atctgtttat tgccttatgt aaatgagtgt ggccatctgt     2341

ataagcctct ttgacatttt cacccagctc tttcttaatg tctgtgttgg cttctgcatc     2401

agcagaaatc tttttaaaag ggttgttata tatgtaaaaa atgttaacag gaaaatgaga     2461

gaaaataaag cagctgagga tacaaatgtg ctggtaggga gcgatattca agatatattg     2521

tgaagtgtga aaaagtaggt tgctgaacca tgtatatagt atgttcccct ttgtgtacaa     2581

aagggtatgt ttgtttaacc tctgtctctt atctctgtat gtgtatgtat ctttgtatgc     2641

atatatacat gtatctgtat gtgaatagac tttgaaaaaa tacagaataa acttcatggt     2701

ggttgccatt gggcagagga gtataggact ggggtctagg ataggagcaa g              2752


<210>  102
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ser Val Ser Ser Gly Val Gln Ile Leu Thr Lys Pro Glu Thr Val 
1               5                   10                  15      


Asp Arg Arg Arg Ser Ala Glu Thr Thr Lys Glu Ala Gly Arg Pro Leu 
            20                  25                  30          


Glu Met Ala Val Ser Glu Pro Glu Ala Ser Ala Ala Glu Trp Lys Gln 
        35                  40                  45              


Leu Asp Pro Ala Gln Ser Asn Leu Tyr Asn Asp Val Met Leu Glu Asn 
    50                  55                  60                  


Tyr Cys Asn Gln Ala Ser Met Gly Cys Gln Ala Pro Lys Pro Asp Met 
65                  70                  75                  80  


Ile Ser Lys Leu Glu Lys Gly Glu Ala Pro Trp Leu Gly Lys Gly Lys 
                85                  90                  95      


Arg Pro Ser Gln Gly Cys Pro Ser Lys Ile Ala Arg Pro Lys Gln Lys 
            100                 105                 110         


Glu Thr Asp Gly Lys Val Gln Lys Asp Asp Asp Gln Leu Glu Asn Ile 
        115                 120                 125             


Gln Lys Ser Gln Asn Lys Leu Leu Arg Glu Val Ala Val Lys Lys Lys 
    130                 135                 140                 


Thr Gln Ala Lys Lys Asn Gly Ser Asp Cys Gly Ser Leu Gly Lys Lys 
145                 150                 155                 160 


Asn Asn Leu His Lys Lys His Val Pro Ser Lys Lys Arg Leu Leu Lys 
                165                 170                 175     


Phe Glu Ser Cys Gly Lys Ile Leu Lys Gln Asn Leu Asp Leu Pro Asp 
            180                 185                 190         


His Ser Arg Asn Cys Val Lys Arg Lys Ser Asp Ala Ala Lys Glu His 
        195                 200                 205             


Lys Lys Ser Phe Asn His Ser Leu Ser Asp Thr Arg Lys Gly Lys Lys 
    210                 215                 220                 


Gln Thr Gly Lys Lys His Glu Lys Leu Ser Ser His Ser Ser Ser Asp 
225                 230                 235                 240 


Lys Cys Asn Lys Thr Gly Lys Lys His Asp Lys Leu Cys Cys His Ser 
                245                 250                 255     


Ser Ser His Ile Lys Gln Asp Lys Ile Gln Thr Gly Glu Lys His Glu 
            260                 265                 270         


Lys Ser Pro Ser Leu Ser Ser Ser Thr Lys His Glu Lys Pro Gln Ala 
        275                 280                 285             


Cys Val Lys Pro Tyr Glu Cys Asn Gln Cys Gly Lys Val Leu Ser His 
    290                 295                 300                 


Lys Gln Gly Leu Ile Asp His Gln Arg Val His Thr Gly Glu Lys Pro 
305                 310                 315                 320 


Tyr Glu Cys Asn Glu Cys Gly Ile Ala Phe Ser Gln Lys Ser His Leu 
                325                 330                 335     


Val Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Ile 
            340                 345                 350         


Gln Cys Gly Lys Ala His Gly His Lys His Ala Leu Thr Asp His Leu 
        355                 360                 365             


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ala Glu Cys Gly Lys 
    370                 375                 380                 


Thr Phe Arg His Ser Ser Asn Leu Ile Gln His Val Arg Ser His Thr 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ser Phe Arg Tyr 
                405                 410                 415     


Asn Ser Ser Leu Thr Glu His Val Arg Thr His Thr Gly Glu Ile Pro 
            420                 425                 430         


Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Lys Tyr Ser Ser Ser Leu 
        435                 440                 445             


Thr Lys His Met Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys Asn 
    450                 455                 460                 


Glu Cys Gly Lys Ala Phe Ser Lys Lys Ser His Leu Ile Ile His Gln 
465                 470                 475                 480 


Arg Thr His Thr Lys Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys 
                485                 490                 495     


Ala Phe Gly His Ser Ser Ser Leu Thr Tyr His Met Arg Thr His Thr 
            500                 505                 510         


Gly Glu Ser Pro Phe Glu Cys Asn Gln Cys Gly Lys Gly Phe Lys Gln 
        515                 520                 525             


Ile Glu Gly Leu Thr Gln His Gln Arg Val His Thr Gly Glu Lys Pro 
    530                 535                 540                 


Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser His Leu 
545                 550                 555                 560 


Ile Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn 
                565                 570                 575     


Glu Cys Glu Lys Ala Phe Asn Ala Lys Ser Gln Leu Val Ile His Gln 
            580                 585                 590         


Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys 
        595                 600                 605             


Thr Phe Lys Gln Asn Ala Ser Leu Thr Lys His Val Lys Thr His Ser 
    610                 615                 620                 


Glu Asp Lys Ser His Glu 
625                 630 


<210>  103
<211>  1266
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (79)..(735)

<400>  103
tgtcccctct ccggagctct tatactctga gccctgctcg gtttaggcct gtctgcggaa       60

tccgcaccaa ccagcacc atg ccc atg ata ctg ggg tac tgg gac atc cgc        111
                    Met Pro Met Ile Leu Gly Tyr Trp Asp Ile Arg           
                    1               5                   10                

ggg ctg gcc cac gcc atc cgc ctg ctc ctg gaa tac aca gac tca agc        159
Gly Leu Ala His Ala Ile Arg Leu Leu Leu Glu Tyr Thr Asp Ser Ser           
            15                  20                  25                    

tat gag gaa aag aag tac acg atg ggg gac gct cct gat tat gac aga        207
Tyr Glu Glu Lys Lys Tyr Thr Met Gly Asp Ala Pro Asp Tyr Asp Arg           
        30                  35                  40                        

agc cag tgg ctg aat gaa aaa ttc aag ctg ggc ctg gac ttt ccc aat        255
Ser Gln Trp Leu Asn Glu Lys Phe Lys Leu Gly Leu Asp Phe Pro Asn           
    45                  50                  55                            

ctg ccc tac ttg att gat ggg gct cac aag atc acc cag agc aac gcc        303
Leu Pro Tyr Leu Ile Asp Gly Ala His Lys Ile Thr Gln Ser Asn Ala           
60                  65                  70                  75            

atc ttg tgc tac att gcc cgc aag cac aac ctg tgt ggg gag aca gaa        351
Ile Leu Cys Tyr Ile Ala Arg Lys His Asn Leu Cys Gly Glu Thr Glu           
                80                  85                  90                

gag gag aag att cgt gtg gac att ttg gag aac cag acc atg gac aac        399
Glu Glu Lys Ile Arg Val Asp Ile Leu Glu Asn Gln Thr Met Asp Asn           
            95                  100                 105                   

cat atg cag ctg ggc atg atc tgc tac aat cca gaa ttt gag aaa ctg        447
His Met Gln Leu Gly Met Ile Cys Tyr Asn Pro Glu Phe Glu Lys Leu           
        110                 115                 120                       

aag cca aag tac ttg gag gaa ctc cct gaa aag cta aag ctc tac tca        495
Lys Pro Lys Tyr Leu Glu Glu Leu Pro Glu Lys Leu Lys Leu Tyr Ser           
    125                 130                 135                           

gag ttt ctg ggg aag cgg cca tgg ttt gca gga aac aag atc act ttt        543
Glu Phe Leu Gly Lys Arg Pro Trp Phe Ala Gly Asn Lys Ile Thr Phe           
140                 145                 150                 155           

gta gat ttt ctc gtc tat gat gtc ctt gac ctc cac cgt ata ttt gag        591
Val Asp Phe Leu Val Tyr Asp Val Leu Asp Leu His Arg Ile Phe Glu           
                160                 165                 170               

ccc aag tgc ttg gac gcc ttc cca aat ctg aag gac ttc atc tcc cgc        639
Pro Lys Cys Leu Asp Ala Phe Pro Asn Leu Lys Asp Phe Ile Ser Arg           
            175                 180                 185                   

ttt gag ggc ttg gag aag atc tct gcc tac atg aag tcc agc cgc ttc        687
Phe Glu Gly Leu Glu Lys Ile Ser Ala Tyr Met Lys Ser Ser Arg Phe           
        190                 195                 200                       

ctc cca aga cct gtg ttc tca aag atg gct gtc tgg ggc aac aag tag        735
Leu Pro Arg Pro Val Phe Ser Lys Met Ala Val Trp Gly Asn Lys               
    205                 210                 215                           

ggccttgaag gccaggaggt gggagtgagg agcccatact cagcctgctg cccaggctgt      795

gcagcgcagc tggactctgc atcccagcac ctgcctcctc gttcctttct cctgtttatt      855

cccatcttta ctcccaagac ttcattgtcc ctcttcactc cccctaaacc cctgtcccat      915

gcaggccctt tgaagcctca gctacccact atccttcgtg aacatcccct cccatcatta      975

cccttccctg cactaaagcc agcctgacct tccttcctgt tagtggttgt gtctgcttta     1035

aagggcctgc ctggcccctc gcctgtggag ctcagccccg agctgtcccc gtgttgcatg     1095

aaggagcagc attgactggt ttacaggccc tgctcctgca gcatggtccc tgccttaggc     1155

ctacctgatg gaagtaaagc ctcaaccaca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1215

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a              1266


<210>  104
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Pro Met Ile Leu Gly Tyr Trp Asp Ile Arg Gly Leu Ala His Ala 
1               5                   10                  15      


Ile Arg Leu Leu Leu Glu Tyr Thr Asp Ser Ser Tyr Glu Glu Lys Lys 
            20                  25                  30          


Tyr Thr Met Gly Asp Ala Pro Asp Tyr Asp Arg Ser Gln Trp Leu Asn 
        35                  40                  45              


Glu Lys Phe Lys Leu Gly Leu Asp Phe Pro Asn Leu Pro Tyr Leu Ile 
    50                  55                  60                  


Asp Gly Ala His Lys Ile Thr Gln Ser Asn Ala Ile Leu Cys Tyr Ile 
65                  70                  75                  80  


Ala Arg Lys His Asn Leu Cys Gly Glu Thr Glu Glu Glu Lys Ile Arg 
                85                  90                  95      


Val Asp Ile Leu Glu Asn Gln Thr Met Asp Asn His Met Gln Leu Gly 
            100                 105                 110         


Met Ile Cys Tyr Asn Pro Glu Phe Glu Lys Leu Lys Pro Lys Tyr Leu 
        115                 120                 125             


Glu Glu Leu Pro Glu Lys Leu Lys Leu Tyr Ser Glu Phe Leu Gly Lys 
    130                 135                 140                 


Arg Pro Trp Phe Ala Gly Asn Lys Ile Thr Phe Val Asp Phe Leu Val 
145                 150                 155                 160 


Tyr Asp Val Leu Asp Leu His Arg Ile Phe Glu Pro Lys Cys Leu Asp 
                165                 170                 175     


Ala Phe Pro Asn Leu Lys Asp Phe Ile Ser Arg Phe Glu Gly Leu Glu 
            180                 185                 190         


Lys Ile Ser Ala Tyr Met Lys Ser Ser Arg Phe Leu Pro Arg Pro Val 
        195                 200                 205             


Phe Ser Lys Met Ala Val Trp Gly Asn Lys 
    210                 215             


<210>  105
<211>  3680
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (399)..(2975)

<400>  105
tgagtaaatg ccgcagattc tggaaagttc tgatcagtgc gatacataag gctgaggaag       60

tgggacctcc ccttttgggt cggtagttca gcgccggcgc cggtgtgcga gccgcggcag      120

agtgaggcag gcaacccgag gtgcggagcg acctgcggag gctgagcccc gctttctccc      180

agggtttctt atcagccagc cgccgctgtc cccgggggag taggaggctc ctgacaggcc      240

gcggctgtct gtgtgtcctt ctgagtgtca gaggaacggc cagaccccgc gggccggagc      300

agaacgcggc cagggcagaa agcggcggca ggagaagcag gcagggggcc ggaggacgca      360

gaccgagacc cgaggcggag gcggaccgcg agccggcc atg tcg gtg gtg ggg ttg      416
                                          Met Ser Val Val Gly Leu         
                                          1               5               

gac gtg ggc tcg cag agc tgc tac atc gcg gta gcc cgg gcc ggg ggc        464
Asp Val Gly Ser Gln Ser Cys Tyr Ile Ala Val Ala Arg Ala Gly Gly           
            10                  15                  20                    

atc gag acc atc gcc aat gag ttc agc gac cgg tgc acc ccg tca gtc        512
Ile Glu Thr Ile Ala Asn Glu Phe Ser Asp Arg Cys Thr Pro Ser Val           
        25                  30                  35                        

ata tca ttt gga tca aaa aat aga aca atc gga gtt gca gcc aaa aat        560
Ile Ser Phe Gly Ser Lys Asn Arg Thr Ile Gly Val Ala Ala Lys Asn           
    40                  45                  50                            

cag caa atc act cat gca aac aat acg gtg tct aac ttc aaa aga ttt        608
Gln Gln Ile Thr His Ala Asn Asn Thr Val Ser Asn Phe Lys Arg Phe           
55                  60                  65                  70            

cat ggc cga gca ttc aat gac ccc ttc att caa aag gag aag gaa aac        656
His Gly Arg Ala Phe Asn Asp Pro Phe Ile Gln Lys Glu Lys Glu Asn           
                75                  80                  85                

ttg agt tac gat ttg gtt cca ttg aaa aat ggt gga gtt gga ata aag        704
Leu Ser Tyr Asp Leu Val Pro Leu Lys Asn Gly Gly Val Gly Ile Lys           
            90                  95                  100                   

gta atg tac atg ggt gaa gaa cat cta ttt agt gtg gag cag ata aca        752
Val Met Tyr Met Gly Glu Glu His Leu Phe Ser Val Glu Gln Ile Thr           
        105                 110                 115                       

gcc atg ttg ttg act aag ctg aag gaa act gct gaa aac agc ctc aag        800
Ala Met Leu Leu Thr Lys Leu Lys Glu Thr Ala Glu Asn Ser Leu Lys           
    120                 125                 130                           

aaa cca gta aca gat tgt gtt att tca gtc ccc tcc ttc ttt aca gat        848
Lys Pro Val Thr Asp Cys Val Ile Ser Val Pro Ser Phe Phe Thr Asp           
135                 140                 145                 150           

gct gag agg cga tct gtg tta gat gct gca cag att gtt ggc cta aac        896
Ala Glu Arg Arg Ser Val Leu Asp Ala Ala Gln Ile Val Gly Leu Asn           
                155                 160                 165               

tgt tta aga ctt atg aat gac atg aca gct gtt gct ttg aat tac gga        944
Cys Leu Arg Leu Met Asn Asp Met Thr Ala Val Ala Leu Asn Tyr Gly           
            170                 175                 180                   

att tat aag cag gat ctc cca agc ctg gat gag aaa cct cgg ata gtg        992
Ile Tyr Lys Gln Asp Leu Pro Ser Leu Asp Glu Lys Pro Arg Ile Val           
        185                 190                 195                       

gtt ttt gtt gat atg gga cat tca gct ttt caa gtg tct gct tgt gct       1040
Val Phe Val Asp Met Gly His Ser Ala Phe Gln Val Ser Ala Cys Ala           
    200                 205                 210                           

ttt aac aag gga aaa ttg aag gta ctg gga aca gct ttt gat cct ttc       1088
Phe Asn Lys Gly Lys Leu Lys Val Leu Gly Thr Ala Phe Asp Pro Phe           
215                 220                 225                 230           

tta gga gga aaa aac ttc gat gaa aag tta gtg gaa cat ttt tgt gca       1136
Leu Gly Gly Lys Asn Phe Asp Glu Lys Leu Val Glu His Phe Cys Ala           
                235                 240                 245               

gaa ttt aaa act aag tac aag ttg gat gca aaa tcc aaa ata cga gca       1184
Glu Phe Lys Thr Lys Tyr Lys Leu Asp Ala Lys Ser Lys Ile Arg Ala           
            250                 255                 260                   

ctc cta cgt ctg tat cag gaa tgt gaa aaa ctg aaa aag cta atg agc       1232
Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys Leu Lys Lys Leu Met Ser           
        265                 270                 275                       

tct aac agc aca gac ctt cca ctg aat atc gaa tgc ttt atg aat gat       1280
Ser Asn Ser Thr Asp Leu Pro Leu Asn Ile Glu Cys Phe Met Asn Asp           
    280                 285                 290                           

aaa gat gtt tcc gga aag atg aac agg tca caa ttt gaa gaa ctc tgt       1328
Lys Asp Val Ser Gly Lys Met Asn Arg Ser Gln Phe Glu Glu Leu Cys           
295                 300                 305                 310           

gct gaa ctt ctg caa aag ata gaa gta ccc ctt tat tca ctg ttg gaa       1376
Ala Glu Leu Leu Gln Lys Ile Glu Val Pro Leu Tyr Ser Leu Leu Glu           
                315                 320                 325               

caa act cat ctc aaa gta gaa gat gtg agt gca gtt gag att gtt gga       1424
Gln Thr His Leu Lys Val Glu Asp Val Ser Ala Val Glu Ile Val Gly           
            330                 335                 340                   

ggc gct aca cga att cca gct gtg aag gaa aga att gcc aaa ttc ttt       1472
Gly Ala Thr Arg Ile Pro Ala Val Lys Glu Arg Ile Ala Lys Phe Phe           
        345                 350                 355                       

gga aaa gat att agc aca aca ctc aat gca gat gaa gca gta gcc aga       1520
Gly Lys Asp Ile Ser Thr Thr Leu Asn Ala Asp Glu Ala Val Ala Arg           
    360                 365                 370                           

gga tgt gca tta cag tgt gca ata ctt tcc ccg gca ttt aaa gtt aga       1568
Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser Pro Ala Phe Lys Val Arg           
375                 380                 385                 390           

gaa ttt tcc gtc aca gat gca gtt cct ttt cca ata tct ctg atc tgg       1616
Glu Phe Ser Val Thr Asp Ala Val Pro Phe Pro Ile Ser Leu Ile Trp           
                395                 400                 405               

aac cat gat tca gaa gat act gaa ggt gtt cat gaa gtc ttt agt cga       1664
Asn His Asp Ser Glu Asp Thr Glu Gly Val His Glu Val Phe Ser Arg           
            410                 415                 420                   

aac cat gct gct cct ttc tcc aaa gtt ctc acc ttt ctg aga agg ggg       1712
Asn His Ala Ala Pro Phe Ser Lys Val Leu Thr Phe Leu Arg Arg Gly           
        425                 430                 435                       

cct ttt gag cta gaa gct ttc tat tct gat ccc caa gga gtt cca tat       1760
Pro Phe Glu Leu Glu Ala Phe Tyr Ser Asp Pro Gln Gly Val Pro Tyr           
    440                 445                 450                           

cca gaa gca aaa ata ggc cgc ttt gta gtt cag aat gtt tct gca cag       1808
Pro Glu Ala Lys Ile Gly Arg Phe Val Val Gln Asn Val Ser Ala Gln           
455                 460                 465                 470           

aaa gat gga gaa aaa tct aga gta aaa gtc aaa gtg cga gtc aac acc       1856
Lys Asp Gly Glu Lys Ser Arg Val Lys Val Lys Val Arg Val Asn Thr           
                475                 480                 485               

cat ggc att ttc acc atc tct acg gca tct atg gtg gag aaa gtc cca       1904
His Gly Ile Phe Thr Ile Ser Thr Ala Ser Met Val Glu Lys Val Pro           
            490                 495                 500                   

act gag gag aat gaa atg tct tct gaa gct gac atg gag tgt ctg aat       1952
Thr Glu Glu Asn Glu Met Ser Ser Glu Ala Asp Met Glu Cys Leu Asn           
        505                 510                 515                       

cag aga cca cca gaa aac cca gac act gat aaa aat gtc cag caa gac       2000
Gln Arg Pro Pro Glu Asn Pro Asp Thr Asp Lys Asn Val Gln Gln Asp           
    520                 525                 530                           

aac agt gaa gct gga aca cag ccc cag gta caa act gat gct caa caa       2048
Asn Ser Glu Ala Gly Thr Gln Pro Gln Val Gln Thr Asp Ala Gln Gln           
535                 540                 545                 550           

acc tca cag tct ccc cct tca cct gaa ctt acc tca gaa gaa aac aaa       2096
Thr Ser Gln Ser Pro Pro Ser Pro Glu Leu Thr Ser Glu Glu Asn Lys           
                555                 560                 565               

atc cca gat gct gac aaa gca aat gaa aaa aaa gtt gac cag cct cca       2144
Ile Pro Asp Ala Asp Lys Ala Asn Glu Lys Lys Val Asp Gln Pro Pro           
            570                 575                 580                   

gaa gct aaa aag ccc aaa ata aag gtg gtg aat gtt gag ctg cct att       2192
Glu Ala Lys Lys Pro Lys Ile Lys Val Val Asn Val Glu Leu Pro Ile           
        585                 590                 595                       

gaa gcc aac ttg gtc tgg cag tta ggg aaa gac ctt ctt aac atg tat       2240
Glu Ala Asn Leu Val Trp Gln Leu Gly Lys Asp Leu Leu Asn Met Tyr           
    600                 605                 610                           

att gag aca gag ggt aag atg ata atg caa gat aaa ttg gaa aaa gaa       2288
Ile Glu Thr Glu Gly Lys Met Ile Met Gln Asp Lys Leu Glu Lys Glu           
615                 620                 625                 630           

agg aat gat gct aaa aat gca gtt gag gaa tat gtg tat gag ttc aga       2336
Arg Asn Asp Ala Lys Asn Ala Val Glu Glu Tyr Val Tyr Glu Phe Arg           
                635                 640                 645               

gac aag ctg tgt gga cca tat gaa aaa ttt ata tgt gag cag gat cat       2384
Asp Lys Leu Cys Gly Pro Tyr Glu Lys Phe Ile Cys Glu Gln Asp His           
            650                 655                 660                   

caa aat ttt ttg aga ctc ctc aca gaa act gaa gac tgg ctg tat gaa       2432
Gln Asn Phe Leu Arg Leu Leu Thr Glu Thr Glu Asp Trp Leu Tyr Glu           
        665                 670                 675                       

gaa gga gag gac caa gct aaa caa gca tat gtt gac aag ttg gaa gaa       2480
Glu Gly Glu Asp Gln Ala Lys Gln Ala Tyr Val Asp Lys Leu Glu Glu           
    680                 685                 690                           

tta atg aaa att ggc act cca gtt aaa gtt cgg ttt cag gaa gct gaa       2528
Leu Met Lys Ile Gly Thr Pro Val Lys Val Arg Phe Gln Glu Ala Glu           
695                 700                 705                 710           

gaa cgg cca aaa atg ttt gaa gaa cta gga cag agg ctg cag cat tat       2576
Glu Arg Pro Lys Met Phe Glu Glu Leu Gly Gln Arg Leu Gln His Tyr           
                715                 720                 725               

gcc aag ata gca gct gac ttc aga aat aag gat gag aaa tac aac cat       2624
Ala Lys Ile Ala Ala Asp Phe Arg Asn Lys Asp Glu Lys Tyr Asn His           
            730                 735                 740                   

att gat gag tct gaa atg aaa aaa gtg gag aag tct gtt aat gaa gtg       2672
Ile Asp Glu Ser Glu Met Lys Lys Val Glu Lys Ser Val Asn Glu Val           
        745                 750                 755                       

atg gaa tgg atg aat aat gtc atg aat gct cag gct aaa aag agt ctt       2720
Met Glu Trp Met Asn Asn Val Met Asn Ala Gln Ala Lys Lys Ser Leu           
    760                 765                 770                           

gat cag gat cca gtt gta cgt gct cag gaa att aaa aca aaa atc aag       2768
Asp Gln Asp Pro Val Val Arg Ala Gln Glu Ile Lys Thr Lys Ile Lys           
775                 780                 785                 790           

gaa ttg aac aac aca tgt gaa ccc gtt gta aca caa ccg aaa cca aaa       2816
Glu Leu Asn Asn Thr Cys Glu Pro Val Val Thr Gln Pro Lys Pro Lys           
                795                 800                 805               

att gaa tca ccc aaa ctg gaa aga act cca aat ggc cca aat att gat       2864
Ile Glu Ser Pro Lys Leu Glu Arg Thr Pro Asn Gly Pro Asn Ile Asp           
            810                 815                 820                   

aaa aag gaa gaa gat tta gaa gac aaa aac aat ttt ggt gct gaa cct       2912
Lys Lys Glu Glu Asp Leu Glu Asp Lys Asn Asn Phe Gly Ala Glu Pro           
        825                 830                 835                       

cca cat cag aat ggt gaa tgt tac cct aat gag aaa aat tct gtt aat       2960
Pro His Gln Asn Gly Glu Cys Tyr Pro Asn Glu Lys Asn Ser Val Asn           
    840                 845                 850                           

atg gac ttg gac tag ataaccttaa attggcctat tccttcaatt aataaaatat       3015
Met Asp Leu Asp                                                           
855                                                                       

ttttgccata gtatgtgact ctacataaca tactgaaact atttatattt tcttttttaa     3075

ggatatttag aaattttgtg tattatatgg aaaaagaaaa aaagcttaag tctgtagtct     3135

ttatgatcct aaaagggaaa attgccttgg taactttcag attcctgtgg aattgtgaat     3195

tcatactaag ctttctgtgc agtctcacca tttgcatcac tgaggatgaa actgactttt     3255

gtcttttgga gaaaaaaaac tgtactgctt gttcaagagg gctgtgatta aaatctttaa     3315

gcatttgttc ctgccaaggt agttttcttg cattttgctc tccattcagc atgtgtgtgg     3375

gtgtggatgt ttataaacaa gactaagtct gacttcataa gggctttcta aaaccatttc     3435

tgtccaagag aaaatgactt tttgctttga tattaaaaat tcaatgagta aaacaaaagc     3495

tagtcaaatg tgttagcagc atgcagaaca aaaactttaa actttctctc tcactataca     3555

gtatattgtc atgtgaaagt gtggaatgga agaaatgtcg atcctgttgt aactgattgt     3615

gaacactttt atgagcttta aaataaagtt catcttatgg tgtcatttct aaaaaaaaaa     3675

aaaaa                                                                 3680


<210>  106
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ser Val Val Gly Leu Asp Val Gly Ser Gln Ser Cys Tyr Ile Ala 
1               5                   10                  15      


Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Phe Ser Asp 
            20                  25                  30          


Arg Cys Thr Pro Ser Val Ile Ser Phe Gly Ser Lys Asn Arg Thr Ile 
        35                  40                  45              


Gly Val Ala Ala Lys Asn Gln Gln Ile Thr His Ala Asn Asn Thr Val 
    50                  55                  60                  


Ser Asn Phe Lys Arg Phe His Gly Arg Ala Phe Asn Asp Pro Phe Ile 
65                  70                  75                  80  


Gln Lys Glu Lys Glu Asn Leu Ser Tyr Asp Leu Val Pro Leu Lys Asn 
                85                  90                  95      


Gly Gly Val Gly Ile Lys Val Met Tyr Met Gly Glu Glu His Leu Phe 
            100                 105                 110         


Ser Val Glu Gln Ile Thr Ala Met Leu Leu Thr Lys Leu Lys Glu Thr 
        115                 120                 125             


Ala Glu Asn Ser Leu Lys Lys Pro Val Thr Asp Cys Val Ile Ser Val 
    130                 135                 140                 


Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Leu Asp Ala Ala 
145                 150                 155                 160 


Gln Ile Val Gly Leu Asn Cys Leu Arg Leu Met Asn Asp Met Thr Ala 
                165                 170                 175     


Val Ala Leu Asn Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ser Leu Asp 
            180                 185                 190         


Glu Lys Pro Arg Ile Val Val Phe Val Asp Met Gly His Ser Ala Phe 
        195                 200                 205             


Gln Val Ser Ala Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Gly 
    210                 215                 220                 


Thr Ala Phe Asp Pro Phe Leu Gly Gly Lys Asn Phe Asp Glu Lys Leu 
225                 230                 235                 240 


Val Glu His Phe Cys Ala Glu Phe Lys Thr Lys Tyr Lys Leu Asp Ala 
                245                 250                 255     


Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys 
            260                 265                 270         


Leu Lys Lys Leu Met Ser Ser Asn Ser Thr Asp Leu Pro Leu Asn Ile 
        275                 280                 285             


Glu Cys Phe Met Asn Asp Lys Asp Val Ser Gly Lys Met Asn Arg Ser 
    290                 295                 300                 


Gln Phe Glu Glu Leu Cys Ala Glu Leu Leu Gln Lys Ile Glu Val Pro 
305                 310                 315                 320 


Leu Tyr Ser Leu Leu Glu Gln Thr His Leu Lys Val Glu Asp Val Ser 
                325                 330                 335     


Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
            340                 345                 350         


Arg Ile Ala Lys Phe Phe Gly Lys Asp Ile Ser Thr Thr Leu Asn Ala 
        355                 360                 365             


Asp Glu Ala Val Ala Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
    370                 375                 380                 


Pro Ala Phe Lys Val Arg Glu Phe Ser Val Thr Asp Ala Val Pro Phe 
385                 390                 395                 400 


Pro Ile Ser Leu Ile Trp Asn His Asp Ser Glu Asp Thr Glu Gly Val 
                405                 410                 415     


His Glu Val Phe Ser Arg Asn His Ala Ala Pro Phe Ser Lys Val Leu 
            420                 425                 430         


Thr Phe Leu Arg Arg Gly Pro Phe Glu Leu Glu Ala Phe Tyr Ser Asp 
        435                 440                 445             


Pro Gln Gly Val Pro Tyr Pro Glu Ala Lys Ile Gly Arg Phe Val Val 
    450                 455                 460                 


Gln Asn Val Ser Ala Gln Lys Asp Gly Glu Lys Ser Arg Val Lys Val 
465                 470                 475                 480 


Lys Val Arg Val Asn Thr His Gly Ile Phe Thr Ile Ser Thr Ala Ser 
                485                 490                 495     


Met Val Glu Lys Val Pro Thr Glu Glu Asn Glu Met Ser Ser Glu Ala 
            500                 505                 510         


Asp Met Glu Cys Leu Asn Gln Arg Pro Pro Glu Asn Pro Asp Thr Asp 
        515                 520                 525             


Lys Asn Val Gln Gln Asp Asn Ser Glu Ala Gly Thr Gln Pro Gln Val 
    530                 535                 540                 


Gln Thr Asp Ala Gln Gln Thr Ser Gln Ser Pro Pro Ser Pro Glu Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Asn Lys Ile Pro Asp Ala Asp Lys Ala Asn Glu Lys 
                565                 570                 575     


Lys Val Asp Gln Pro Pro Glu Ala Lys Lys Pro Lys Ile Lys Val Val 
            580                 585                 590         


Asn Val Glu Leu Pro Ile Glu Ala Asn Leu Val Trp Gln Leu Gly Lys 
        595                 600                 605             


Asp Leu Leu Asn Met Tyr Ile Glu Thr Glu Gly Lys Met Ile Met Gln 
    610                 615                 620                 


Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Glu Glu 
625                 630                 635                 640 


Tyr Val Tyr Glu Phe Arg Asp Lys Leu Cys Gly Pro Tyr Glu Lys Phe 
                645                 650                 655     


Ile Cys Glu Gln Asp His Gln Asn Phe Leu Arg Leu Leu Thr Glu Thr 
            660                 665                 670         


Glu Asp Trp Leu Tyr Glu Glu Gly Glu Asp Gln Ala Lys Gln Ala Tyr 
        675                 680                 685             


Val Asp Lys Leu Glu Glu Leu Met Lys Ile Gly Thr Pro Val Lys Val 
    690                 695                 700                 


Arg Phe Gln Glu Ala Glu Glu Arg Pro Lys Met Phe Glu Glu Leu Gly 
705                 710                 715                 720 


Gln Arg Leu Gln His Tyr Ala Lys Ile Ala Ala Asp Phe Arg Asn Lys 
                725                 730                 735     


Asp Glu Lys Tyr Asn His Ile Asp Glu Ser Glu Met Lys Lys Val Glu 
            740                 745                 750         


Lys Ser Val Asn Glu Val Met Glu Trp Met Asn Asn Val Met Asn Ala 
        755                 760                 765             


Gln Ala Lys Lys Ser Leu Asp Gln Asp Pro Val Val Arg Ala Gln Glu 
    770                 775                 780                 


Ile Lys Thr Lys Ile Lys Glu Leu Asn Asn Thr Cys Glu Pro Val Val 
785                 790                 795                 800 


Thr Gln Pro Lys Pro Lys Ile Glu Ser Pro Lys Leu Glu Arg Thr Pro 
                805                 810                 815     


Asn Gly Pro Asn Ile Asp Lys Lys Glu Glu Asp Leu Glu Asp Lys Asn 
            820                 825                 830         


Asn Phe Gly Ala Glu Pro Pro His Gln Asn Gly Glu Cys Tyr Pro Asn 
        835                 840                 845             


Glu Lys Asn Ser Val Asn Met Asp Leu Asp 
    850                 855             


<210>  107
<211>  2500
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (132)..(953)

<400>  107
gtcctgagta ttgctcttca cgcttcagtc ggacaggcct gtattccatg ggaaagtcca       60

ttggccattt ttaactgggg ctatttcttt tctcttatgg actatatcag gccacagtgg      120

tctccaaggg c atg ata ctc aaa ggt tgt ctc ctg tat cct ttg tgc tct       170
             Met Ile Leu Lys Gly Cys Leu Leu Tyr Pro Leu Cys Ser          
             1               5                   10                       

ccc agg aat aag caa aga tgt gcc agg ctg tgg aaa ata gcc tat gga        218
Pro Arg Asn Lys Gln Arg Cys Ala Arg Leu Trp Lys Ile Ala Tyr Gly           
    15                  20                  25                            

gga tta cta aag ata gtg act ggc tcc ctc tta aca ttt tat gtg gtt        266
Gly Leu Leu Lys Ile Val Thr Gly Ser Leu Leu Thr Phe Tyr Val Val           
30                  35                  40                  45            

ctc tgt ctt gat ggc ggg atg gtg ctc atg agg aag caa gtg cca tca        314
Leu Cys Leu Asp Gly Gly Met Val Leu Met Arg Lys Gln Val Pro Ser           
                50                  55                  60                

agg ttc atg tac ccc aaa gag tgg cag cac ctc acc atg ttc atc ctc        362
Arg Phe Met Tyr Pro Lys Glu Trp Gln His Leu Thr Met Phe Ile Leu           
            65                  70                  75                    

ctc act ctt aat ggc tgt gtg gac ttc atg agc aag aat gtg ctg cct        410
Leu Thr Leu Asn Gly Cys Val Asp Phe Met Ser Lys Asn Val Leu Pro           
        80                  85                  90                        

cag agg tgt gtg ggc cta gaa aaa ggt acc ctg gtc ctg atc atc tac        458
Gln Arg Cys Val Gly Leu Glu Lys Gly Thr Leu Val Leu Ile Ile Tyr           
    95                  100                 105                           

gag ctc ctg ctg ctg atg gtg tca cat gtt aaa gat tca gaa ggg gtg        506
Glu Leu Leu Leu Leu Met Val Ser His Val Lys Asp Ser Glu Gly Val           
110                 115                 120                 125           

gag ctg cac gtt tat tct ctg ctc atc ttg gtg gtg ttc ctg ctg ttg        554
Glu Leu His Val Tyr Ser Leu Leu Ile Leu Val Val Phe Leu Leu Leu           
                130                 135                 140               

ctg gtg ttg act gca gag ctg tgg gct ccc aac atg tgt cat ctc cag        602
Leu Val Leu Thr Ala Glu Leu Trp Ala Pro Asn Met Cys His Leu Gln           
            145                 150                 155                   

ctg atg gag acc ttt ctg att ctg atg atg ggc tcc tgg ctg atg cag        650
Leu Met Glu Thr Phe Leu Ile Leu Met Met Gly Ser Trp Leu Met Gln           
        160                 165                 170                       

gca ggc ttt att cta tac aga ccc gtc tct ggc tac cca tgg cag gac        698
Ala Gly Phe Ile Leu Tyr Arg Pro Val Ser Gly Tyr Pro Trp Gln Asp           
    175                 180                 185                           

gat gac atc agt gac atc atg ttt gtc acc acc ttc ttc tgc tgg cat        746
Asp Asp Ile Ser Asp Ile Met Phe Val Thr Thr Phe Phe Cys Trp His           
190                 195                 200                 205           

gtg atg atc aat gcc tca ttc ctg ttg gga atc tat ggc ttc tct tcc        794
Val Met Ile Asn Ala Ser Phe Leu Leu Gly Ile Tyr Gly Phe Ser Ser           
                210                 215                 220               

ttt tgg tat cat tgt ttc aga ccc agc ttg aag ctg act ggg ccc aaa        842
Phe Trp Tyr His Cys Phe Arg Pro Ser Leu Lys Leu Thr Gly Pro Lys           
            225                 230                 235                   

gaa gct cca tat tat gca agc act cca gga ccc ctc tac aag ttg cta        890
Glu Ala Pro Tyr Tyr Ala Ser Thr Pro Gly Pro Leu Tyr Lys Leu Leu           
        240                 245                 250                       

cag gaa gtg gag cag tca gag aaa gag gac cag gct ctc ctc ctt cca        938
Gln Glu Val Glu Gln Ser Glu Lys Glu Asp Gln Ala Leu Leu Leu Pro           
    255                 260                 265                           

aag agc tcc ccc tga gacagggcct acagtggctg gcacatcgtc cacctcatct        993
Lys Ser Ser Pro                                                           
270                                                                       

tcctcctgtt ggctcctcag ccacgagcat ggtaccctcc ttggtaaagg taatggcctt     1053

gaaggctagc agttggtccc gtctgctggt tcattttctt ttcttctctt ttcttttttt     1113

ttttttttga gacagagtct cgctctgttg cccagcctgg agtgcaatgg cacaatctca     1173

gctcagtgca acctccgcct cccgagttca agcgattctc ctgcctcagc ctcccgagta     1233

gctgcaatta caggagcctg ccaccatgcc cgtgctggtg cattttctgt ccctgagcct     1293

ctaattactg agaagataag gggagaggga ttgagaaaga gacgctgatg ggatttgcgg     1353

gagggaggga aaaggacgag gagaacactt cttcttagtg tgcaagaaaa gccactgggg     1413

gaagagaatg caacaaaagg aagagctgtg aagggaggag aacagagtct agcagttatg     1473

ctgtcattag cgtcatcagg cacaagggat tgccttttac ctgagggaat aaagacttct     1533

cacaactcaa aactggaccc attcaaatct catcttgata aagaaaagtg ggtactttac     1593

gtgctcacca aagtggtgcc accatgtgga aatagcatga tagaatttat aattaattca     1653

tacaggctga aattatgctc gctttgcctc cttctctctc cgcagctttc aagaattggc     1713

ttcatttcaa actttacata taaagtgaga ctttttaaat acttaataac atttcaaatt     1773

tccataattt aaatttgtat agaattcaac tgctatagca tttttatagc attcaaatgc     1833

ttggtacttc cctgacttct cattttatta ctcttattct agcccaaact ttccttttca     1893

ccatgaccac ccttgcacat gcaatttagc agataccatt cttgggtctt tgcaaatttc     1953

ttttccttgc aaatcacagc cagtcatcct acagtcacat atttaccatg ttattcgatt     2013

cccagaataa acctacatcc acccccacac cgcaccaagt atccccaagg tggccttctc     2073

cagaactctt actgattccc ttgttttgga actcttgggc acttacatta aatctgcttt     2133

gttagtttgc tcatacaggt gacccacttt cttttatact gctgctgaaa tcattttctt     2193

tcagaaggtt cttcctcacc cactaaagta caggctccta aagggaaaag actttgcctt     2253

atccaagtta ccaaatttcc tatgtatact ccagctatgg atcatggtta tgtttaataa     2313

agccttcttt gcttccagag tcttccctaa tcctgtttct tctaaatgta ttgctggaca     2373

ggttggaggt tttgtgaatc tctctgggtg acaacaacag tcctgaacac tgagtcactg     2433

ccttagtaat gcacccactc tcttccttgt tttggggtat aataaaatcc agtaacttgt     2493

ttctgaa                                                               2500


<210>  108
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ile Leu Lys Gly Cys Leu Leu Tyr Pro Leu Cys Ser Pro Arg Asn 
1               5                   10                  15      


Lys Gln Arg Cys Ala Arg Leu Trp Lys Ile Ala Tyr Gly Gly Leu Leu 
            20                  25                  30          


Lys Ile Val Thr Gly Ser Leu Leu Thr Phe Tyr Val Val Leu Cys Leu 
        35                  40                  45              


Asp Gly Gly Met Val Leu Met Arg Lys Gln Val Pro Ser Arg Phe Met 
    50                  55                  60                  


Tyr Pro Lys Glu Trp Gln His Leu Thr Met Phe Ile Leu Leu Thr Leu 
65                  70                  75                  80  


Asn Gly Cys Val Asp Phe Met Ser Lys Asn Val Leu Pro Gln Arg Cys 
                85                  90                  95      


Val Gly Leu Glu Lys Gly Thr Leu Val Leu Ile Ile Tyr Glu Leu Leu 
            100                 105                 110         


Leu Leu Met Val Ser His Val Lys Asp Ser Glu Gly Val Glu Leu His 
        115                 120                 125             


Val Tyr Ser Leu Leu Ile Leu Val Val Phe Leu Leu Leu Leu Val Leu 
    130                 135                 140                 


Thr Ala Glu Leu Trp Ala Pro Asn Met Cys His Leu Gln Leu Met Glu 
145                 150                 155                 160 


Thr Phe Leu Ile Leu Met Met Gly Ser Trp Leu Met Gln Ala Gly Phe 
                165                 170                 175     


Ile Leu Tyr Arg Pro Val Ser Gly Tyr Pro Trp Gln Asp Asp Asp Ile 
            180                 185                 190         


Ser Asp Ile Met Phe Val Thr Thr Phe Phe Cys Trp His Val Met Ile 
        195                 200                 205             


Asn Ala Ser Phe Leu Leu Gly Ile Tyr Gly Phe Ser Ser Phe Trp Tyr 
    210                 215                 220                 


His Cys Phe Arg Pro Ser Leu Lys Leu Thr Gly Pro Lys Glu Ala Pro 
225                 230                 235                 240 


Tyr Tyr Ala Ser Thr Pro Gly Pro Leu Tyr Lys Leu Leu Gln Glu Val 
                245                 250                 255     


Glu Gln Ser Glu Lys Glu Asp Gln Ala Leu Leu Leu Pro Lys Ser Ser 
            260                 265                 270         


Pro 
    


<210>  109
<211>  802
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (253)..(696)

<400>  109
gctggccgtg ggagaggctt aaaacaaacg ccggaagcaa ctcccagccc cataaagatc       60

tgtgaccggc agccccagac ctgcctgcct tcctgacttc tgttccagag caaaggtcat      120

tcagccgctt gaatcagcct tttcccccca cccggtcccc aactttgttt acccgataag      180

gaaggtcagc attcaaagtc aagaagcgcc atttatcttc ccgtgcgctc tacaaatagt      240

tccgtgagaa ag atg gcc ggg aac tcg atc ctg ctg gct gct gtc tct att      291
              Met Ala Gly Asn Ser Ile Leu Leu Ala Ala Val Ser Ile         
              1               5                   10                      

ctc tcg gcc tgt cag caa agt tat ttt gct ttg caa gtt gga aag gca        339
Leu Ser Ala Cys Gln Gln Ser Tyr Phe Ala Leu Gln Val Gly Lys Ala           
    15                  20                  25                            

aga tta aaa tac aaa gtt acg ccc cca gca gtc act ggg tca cca gag        387
Arg Leu Lys Tyr Lys Val Thr Pro Pro Ala Val Thr Gly Ser Pro Glu           
30                  35                  40                  45            

ttt gag aga gta ttt cgg gca caa caa aac tgt gtg gag ttt tat cct        435
Phe Glu Arg Val Phe Arg Ala Gln Gln Asn Cys Val Glu Phe Tyr Pro           
                50                  55                  60                

ata ttc ata att aca ttg tgg atg gct ggg tgg tat ttc aac caa gtt        483
Ile Phe Ile Ile Thr Leu Trp Met Ala Gly Trp Tyr Phe Asn Gln Val           
            65                  70                  75                    

ttt gct act tgt ctg ggt ctg gtg tac ata tat ggc cgt cac cta tac        531
Phe Ala Thr Cys Leu Gly Leu Val Tyr Ile Tyr Gly Arg His Leu Tyr           
        80                  85                  90                        

ttc tgg gga tat tca gaa gct gct aaa aaa cgg atc acc ggt ttc cga        579
Phe Trp Gly Tyr Ser Glu Ala Ala Lys Lys Arg Ile Thr Gly Phe Arg           
    95                  100                 105                           

ctg agt ctg ggg att ttg gcc ttg ttg acc ctc cta ggt gcc ctg gga        627
Leu Ser Leu Gly Ile Leu Ala Leu Leu Thr Leu Leu Gly Ala Leu Gly           
110                 115                 120                 125           

att gca aac agc ttt ctg gat gaa tat ctg gac ctc aat att gcc aag        675
Ile Ala Asn Ser Phe Leu Asp Glu Tyr Leu Asp Leu Asn Ile Ala Lys           
                130                 135                 140               

aaa ctg agg cgg caa ttc taa ctttttctct tccctttaat gcttgcagaa           726
Lys Leu Arg Arg Gln Phe                                                   
            145                                                           

gctgttccca ccatgaaggt aatatggtat catttgttaa ataaaaataa agtctttatt      786

ctgtttttct tgaaaa                                                      802


<210>  110
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Ala Gly Asn Ser Ile Leu Leu Ala Ala Val Ser Ile Leu Ser Ala 
1               5                   10                  15      


Cys Gln Gln Ser Tyr Phe Ala Leu Gln Val Gly Lys Ala Arg Leu Lys 
            20                  25                  30          


Tyr Lys Val Thr Pro Pro Ala Val Thr Gly Ser Pro Glu Phe Glu Arg 
        35                  40                  45              


Val Phe Arg Ala Gln Gln Asn Cys Val Glu Phe Tyr Pro Ile Phe Ile 
    50                  55                  60                  


Ile Thr Leu Trp Met Ala Gly Trp Tyr Phe Asn Gln Val Phe Ala Thr 
65                  70                  75                  80  


Cys Leu Gly Leu Val Tyr Ile Tyr Gly Arg His Leu Tyr Phe Trp Gly 
                85                  90                  95      


Tyr Ser Glu Ala Ala Lys Lys Arg Ile Thr Gly Phe Arg Leu Ser Leu 
            100                 105                 110         


Gly Ile Leu Ala Leu Leu Thr Leu Leu Gly Ala Leu Gly Ile Ala Asn 
        115                 120                 125             


Ser Phe Leu Asp Glu Tyr Leu Asp Leu Asn Ile Ala Lys Lys Leu Arg 
    130                 135                 140                 


Arg Gln Phe 
145         


<210>  111
<211>  10636
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (972)..(3419)

<400>  111
gaggagagag cagagtatac cgcagacatc atttctacta cagtggcgga gccgtacagg       60

acctgtttca ctgcaggggg atccaaaaca agccccgtgg agcagcagcc agagcaacag      120

cagccgcaag acattgtttc tctccctctg cccccccttc cccacgcaac cccagatcca      180

tttacacttt acagttttac ctcacaaaaa ctactacaag caccaagctc cctgatggaa      240

aggagcatcg tgcatcaagt caccagggtg gtccattcaa gctgcagatt tgtttgtcat      300

ccttgtacag caatctcctc ctccactgcc actacaggga agtgcatcac atgtcagcat      360

actggagcat agtgaaagag tctattttga agcttcaaac ttagtgctgc tgcagaccag      420

gaacaagaga gaaagagtgg atttcagcct gcacggatgg tcttgaaaca caaatggttt      480

ttggtctagg cgttttacac tgagattctc cactgccacc ctttctactc aagcaaaatc      540

ttcgtgaaaa gatctgctgc aaggaactga tagcttatgg ttctccattg tgatgaaagc      600

acatggtaca gttttccaaa gaaattagac cattttcttc gtgagaaaga aatcgacgtg      660

ctgttttcat agggtatttc tcacttctct gtgaaaggaa gaaagaacac gcctgagccc      720

aagagccctc aggagccctc cagagcctgt gggaagtctc catggtgaag tataggctga      780

ggctacctgt gaacagtacg cagtgaatgt tcatccagag ctgctgttgg cggattgtac      840

ccacggggag atgattcctc atgaagagcc tggatcccct acagaaatca aatgtgactt      900

tccgtttatc agactaaaat cagagccatc cagacagtga aacagtcacc gtggaggggg      960

gacggcgaaa a atg aaa tcc aac caa gag cgg agc aac gaa tgc ctg cct      1010
             Met Lys Ser Asn Gln Glu Arg Ser Asn Glu Cys Leu Pro          
             1               5                   10                       

ccc aag aag cgc gag atc ccc gcc acc agc cgg tcc tcc gag gag aag       1058
Pro Lys Lys Arg Glu Ile Pro Ala Thr Ser Arg Ser Ser Glu Glu Lys           
    15                  20                  25                            

gcc cct acc ctg ccc agc gac aac cac cgg gtg gag ggc aca gca tgg       1106
Ala Pro Thr Leu Pro Ser Asp Asn His Arg Val Glu Gly Thr Ala Trp           
30                  35                  40                  45            

ctc ccg ggc aac cct ggt ggc cgg ggc cac ggg ggc ggg agg cat ggg       1154
Leu Pro Gly Asn Pro Gly Gly Arg Gly His Gly Gly Gly Arg His Gly           
                50                  55                  60                

ccg gca ggg acc tcg gtg gag ctt ggt tta caa cag gga ata ggt tta       1202
Pro Ala Gly Thr Ser Val Glu Leu Gly Leu Gln Gln Gly Ile Gly Leu           
            65                  70                  75                    

cac aaa gca ttg tcc aca ggg ctg gac tac tcc ccg ccc agc gct ccc       1250
His Lys Ala Leu Ser Thr Gly Leu Asp Tyr Ser Pro Pro Ser Ala Pro           
        80                  85                  90                        

agg tct gtc ccc gtg gcc acc acg ctg cct gcc gcg tac gcc acc ccg       1298
Arg Ser Val Pro Val Ala Thr Thr Leu Pro Ala Ala Tyr Ala Thr Pro           
    95                  100                 105                           

cag cca ggg acc ccg gtg tcc ccc gtg cag tac gct cac ctg ccg cac       1346
Gln Pro Gly Thr Pro Val Ser Pro Val Gln Tyr Ala His Leu Pro His           
110                 115                 120                 125           

acc ttc cag ttc att ggg tcc tcc caa tac agt gga acc tat gcc agc       1394
Thr Phe Gln Phe Ile Gly Ser Ser Gln Tyr Ser Gly Thr Tyr Ala Ser           
                130                 135                 140               

ttc atc cca tca cag ctg atc ccc cca acc gcc aac ccc gtc acc agt       1442
Phe Ile Pro Ser Gln Leu Ile Pro Pro Thr Ala Asn Pro Val Thr Ser           
            145                 150                 155                   

gca gtg gcc tcg gcc gca ggg gcc acc act cca tcc cag cgc tcc cag       1490
Ala Val Ala Ser Ala Ala Gly Ala Thr Thr Pro Ser Gln Arg Ser Gln           
        160                 165                 170                       

ctg gag gcc tat tcc act ctg ctg gcc aac atg ggc agt ctg agc cag       1538
Leu Glu Ala Tyr Ser Thr Leu Leu Ala Asn Met Gly Ser Leu Ser Gln           
    175                 180                 185                           

acg ccg gga cac aag gct gag cag cag cag cag cag cag cag cag cag       1586
Thr Pro Gly His Lys Ala Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln           
190                 195                 200                 205           

cag cag cag cat cag cat cag cag cag cag cag cag cag cag cag cag       1634
Gln Gln Gln His Gln His Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln           
                210                 215                 220               

cag cag cag cag cac ctc agc agg gct ccg ggg ctc atc acc ccg ggg       1682
Gln Gln Gln Gln His Leu Ser Arg Ala Pro Gly Leu Ile Thr Pro Gly           
            225                 230                 235                   

tcc ccc cca cca gcc cag cag aac cag tac gtc cac att tcc agt tct       1730
Ser Pro Pro Pro Ala Gln Gln Asn Gln Tyr Val His Ile Ser Ser Ser           
        240                 245                 250                       

ccg cag aac acc ggc cgc acc gcc tct cct ccg gcc atc ccc gtc cac       1778
Pro Gln Asn Thr Gly Arg Thr Ala Ser Pro Pro Ala Ile Pro Val His           
    255                 260                 265                           

ctc cac ccc cac cag acg atg atc cca cac acg ctc acc ctg ggg ccc       1826
Leu His Pro His Gln Thr Met Ile Pro His Thr Leu Thr Leu Gly Pro           
270                 275                 280                 285           

ccc tcc cag gtc gtc atg caa tac gcc gac tcc ggc agc cac ttt gtc       1874
Pro Ser Gln Val Val Met Gln Tyr Ala Asp Ser Gly Ser His Phe Val           
                290                 295                 300               

cct cgg gag gcc acc aag aaa gct gag agc agc cgg ctg cag cag gcc       1922
Pro Arg Glu Ala Thr Lys Lys Ala Glu Ser Ser Arg Leu Gln Gln Ala           
            305                 310                 315                   

atc cag gcc aag gag gtc ctg aac ggt gag atg gag aag agc cgg cgg       1970
Ile Gln Ala Lys Glu Val Leu Asn Gly Glu Met Glu Lys Ser Arg Arg           
        320                 325                 330                       

tac ggg gcc ccg tcc tca gcc gac ctg ggc ctg ggc aag gca ggc ggc       2018
Tyr Gly Ala Pro Ser Ser Ala Asp Leu Gly Leu Gly Lys Ala Gly Gly           
    335                 340                 345                           

aag tcg gtt cct cac ccg tac gag tcc agg cac gtg gtg gtc cac ccg       2066
Lys Ser Val Pro His Pro Tyr Glu Ser Arg His Val Val Val His Pro           
350                 355                 360                 365           

agc ccc tca gac tac agc agt cgt gat cct tcg ggg gtc cgg gcc tct       2114
Ser Pro Ser Asp Tyr Ser Ser Arg Asp Pro Ser Gly Val Arg Ala Ser           
                370                 375                 380               

gtg atg gtc ctg ccc aac agc aac acg ccc gca gct gac ctg gag gtg       2162
Val Met Val Leu Pro Asn Ser Asn Thr Pro Ala Ala Asp Leu Glu Val           
            385                 390                 395                   

caa cag gcc act cat cgt gaa gcc tcc cct tct acc ctc aac gac aaa       2210
Gln Gln Ala Thr His Arg Glu Ala Ser Pro Ser Thr Leu Asn Asp Lys           
        400                 405                 410                       

agt ggc ctg cat tta ggg aag cct ggc cac cgg tcc tac gcg ctc tca       2258
Ser Gly Leu His Leu Gly Lys Pro Gly His Arg Ser Tyr Ala Leu Ser           
    415                 420                 425                           

ccc cac acg gtc att cag acc aca cac agt gct tca gag cca ctc ccg       2306
Pro His Thr Val Ile Gln Thr Thr His Ser Ala Ser Glu Pro Leu Pro           
430                 435                 440                 445           

gtg gga ctg cca gcc acg gcc ttc tac gca ggg act caa ccc cct gtc       2354
Val Gly Leu Pro Ala Thr Ala Phe Tyr Ala Gly Thr Gln Pro Pro Val           
                450                 455                 460               

atc ggc tac ctg agc ggc cag cag caa gca atc acc tac gcc ggc agc       2402
Ile Gly Tyr Leu Ser Gly Gln Gln Gln Ala Ile Thr Tyr Ala Gly Ser           
            465                 470                 475                   

ctg ccc cag cac ctg gtg atc ccc ggc aca cag ccc ctg ctc atc ccg       2450
Leu Pro Gln His Leu Val Ile Pro Gly Thr Gln Pro Leu Leu Ile Pro           
        480                 485                 490                       

gtc ggc agc act gac atg gaa gcg tcg ggg gca gcc ccg gcc ata gtc       2498
Val Gly Ser Thr Asp Met Glu Ala Ser Gly Ala Ala Pro Ala Ile Val           
    495                 500                 505                           

acg tca tcc ccc cag ttt gct gca gtg cct cac acg ttc gtc acc acc       2546
Thr Ser Ser Pro Gln Phe Ala Ala Val Pro His Thr Phe Val Thr Thr           
510                 515                 520                 525           

gcc ctt ccc aag agc gag aac ttc aac cct gag gcc ctg gtc acc cag       2594
Ala Leu Pro Lys Ser Glu Asn Phe Asn Pro Glu Ala Leu Val Thr Gln           
                530                 535                 540               

gcc gcc tac cca gcc atg gtg cag gcc cag atc cac ctg cct gtg gtg       2642
Ala Ala Tyr Pro Ala Met Val Gln Ala Gln Ile His Leu Pro Val Val           
            545                 550                 555                   

cag tcc gtg gcc tcc ccg gcg gcg gct ccc cct acg ctg cct ccc tac       2690
Gln Ser Val Ala Ser Pro Ala Ala Ala Pro Pro Thr Leu Pro Pro Tyr           
        560                 565                 570                       

ttc atg aaa ggc tcc atc atc cag ttg gcc aac ggg gag cta aag aag       2738
Phe Met Lys Gly Ser Ile Ile Gln Leu Ala Asn Gly Glu Leu Lys Lys           
    575                 580                 585                           

gtg gaa gac tta aaa aca gaa gat ttc atc cag agt gca gag ata agc       2786
Val Glu Asp Leu Lys Thr Glu Asp Phe Ile Gln Ser Ala Glu Ile Ser           
590                 595                 600                 605           

aac gac ctg aag atc gac tcc agc acc gta gag agg att gaa gac agc       2834
Asn Asp Leu Lys Ile Asp Ser Ser Thr Val Glu Arg Ile Glu Asp Ser           
                610                 615                 620               

cat agc ccg ggc gtg gcc gtg ata cag ttc gcc gtc ggg gag cac cga       2882
His Ser Pro Gly Val Ala Val Ile Gln Phe Ala Val Gly Glu His Arg           
            625                 630                 635                   

gcc cag gtc agc gtt gaa gtt ttg gta gag tat cct ttt ttt gtg ttt       2930
Ala Gln Val Ser Val Glu Val Leu Val Glu Tyr Pro Phe Phe Val Phe           
        640                 645                 650                       

gga cag ggc tgg tca tcc tgc tgt ccg gag aga acc agc cag ctc ttt       2978
Gly Gln Gly Trp Ser Ser Cys Cys Pro Glu Arg Thr Ser Gln Leu Phe           
    655                 660                 665                           

gat ttg ccg tgt tcc aaa ctc tca gtt ggg gat gtc tgc atc tcg ctt       3026
Asp Leu Pro Cys Ser Lys Leu Ser Val Gly Asp Val Cys Ile Ser Leu           
670                 675                 680                 685           

acc ctc aag aac ctg aag aac ggc tct gtt aaa aag ggc cag ccc gtg       3074
Thr Leu Lys Asn Leu Lys Asn Gly Ser Val Lys Lys Gly Gln Pro Val           
                690                 695                 700               

gat ccc gcc agc gtc ctg ctg aag cac tca aag gcc gac ggc ctg gcg       3122
Asp Pro Ala Ser Val Leu Leu Lys His Ser Lys Ala Asp Gly Leu Ala           
            705                 710                 715                   

ggc agc aga cac agg tat gcc gag cag gaa aac gga atc aac cag ggg       3170
Gly Ser Arg His Arg Tyr Ala Glu Gln Glu Asn Gly Ile Asn Gln Gly           
        720                 725                 730                       

agt gcc cag atg ctc tct gag aat ggc gaa ctg aag ttt cca gag aaa       3218
Ser Ala Gln Met Leu Ser Glu Asn Gly Glu Leu Lys Phe Pro Glu Lys           
    735                 740                 745                           

atg gga ttg cct gca gcg ccc ttc ctc acc aaa ata gaa ccc agc aag       3266
Met Gly Leu Pro Ala Ala Pro Phe Leu Thr Lys Ile Glu Pro Ser Lys           
750                 755                 760                 765           

ccc gcg gca acg agg aag agg agg tgg tcg gcg cca gag agc cgc aaa       3314
Pro Ala Ala Thr Arg Lys Arg Arg Trp Ser Ala Pro Glu Ser Arg Lys           
                770                 775                 780               

ctg gag aag tca gaa gac gaa cca cct ttg act ctt cct aag cct tct       3362
Leu Glu Lys Ser Glu Asp Glu Pro Pro Leu Thr Leu Pro Lys Pro Ser           
            785                 790                 795                   

cta att cct cag gag gtt aag att tgc att gaa ggc cgg tct aat gta       3410
Leu Ile Pro Gln Glu Val Lys Ile Cys Ile Glu Gly Arg Ser Asn Val           
        800                 805                 810                       

ggc aag tag aggcagcgtg ggggaaagga aacgtggctc tcccttatca               3459
Gly Lys                                                                   
    815                                                                   

tttgtatcca gattactgta ctgtaggcta aaataacaca gtatttacat gttatcttct     3519

taattttagg tttctgttct aaccttgtca ttagagttac agcaggtgtg tcgcaggaga     3579

ctggtgcata tgctttttcc acgagtgtct gtcagtgagc gggcgggagg aagggcacag     3639

caggagcggt cagggctcca ggcatccccg gggaagaaag gaacggggct tcacagtgcc     3699

tgccttctct agcggcacag aagcagccgg gggcgctgac tcccgctagt gtcaggagaa     3759

aagtcccgtg ggaagggtcc tgcaggggtg cagggttgca cgcatgtggg ggtgcacagg     3819

cgctgtggcg gcgagtgagg gtctcttttt ctctgcctcc ctctgcctca ctctcttgct     3879

atcggcatgg gccggggggg ttcagagcag tgtcctcctg gggttcccac gtgcaaaatc     3939

aacatcagga acccagcttc agggcatcgc ggagacgcgt cagatggcag atttggaaag     3999

ttaaccattt aaaagaacat ttttctctcc aacatatttt acaataaaag caacttttaa     4059

ttgtatagat atatatttcc ccctatgggg cctgactgca ctgatatata ttttttttaa     4119

agagcaactg ccacatgcgg gatttcattt ctgcttttta ctagtgcagc gatgtcacca     4179

gggtgttgtg gtggacaggg aagcccctgc tgtcatggcc ccacatgggg taaggggggt     4239

tgggggtggg ggagagggag agagcgaaca cccacgctgg tttctgtgca gtgttaggaa     4299

aaccaatcag gttattgcat tgacttcact cccaagaggt agatgcaaac tgcccttcag     4359

tgagagcaac agaagctctt cacgttgagt ttgcgaaatc tttttgtctt tgaactctag     4419

tactgtttat agttcatgac tatggacaac tcgggtgcca cttttttttt ttttcagatt     4479

ccagtgtgac atgaggaatt agattttgaa gatgagcata tattactatc tttaagcatt     4539

taaaaatact gttcacactt tattaccaag catcttggtc tctcattcaa caagtactgt     4599

atctcacttt aaactctttg gggaaaaaac aaaaacaaaa aaaactaagt tgctttcttt     4659

ttttcaacac tgtaactaca tttcagctct gcagaattgc tgaagagcaa gatattgaaa     4719

gtttcaatgt ggtttaaagg gatgaatgtg aattatgaac tagtatgtga caataaatga     4779

ccaccaagta ctacctgacg ggaggcactt ttcactttga tgtctgagaa tcagttcaag     4839

gcatatgcag agttggcaga gaaactgaga gaaaagggat ggagaagaga atactcattt     4899

ttgtccagtg tttttctttt taagatgaac ttttaaagaa ccttgcgatt tgcacatatt     4959

gagtttataa cttgtgtgat attcctgcag tttttatcca ataacattgt gggaaaggtt     5019

tgggggactg aacgagcata aataaatgta gcaaaatttc tttctaacct gcctaaactc     5079

taggccattt tataaggtta tgttcctttg aaaattcatt ttggtctttt taccacatct     5139

gtcacaaaaa gccaggtctt agcgggctct tagaaactct gagaattttc ttcagattca     5199

ttgagagagt tttccataaa gacatttata tatgtgagca agattttttt taaacaatta     5259

ctttattatt gttgttatta atgttatttt cagaatggct tttttttttc tattcaaaat     5319

caaatcgaga tttaatgttt ggtacaaacc cagaaagggt atttcatagt ttttaaacct     5379

ttcattccca gagatccgaa atatcatttg tgggttttga atgcatcttt aaagtgcttt     5439

aaaaaaaagt tttataagta gggagaaatt tttaaatatt cttacttgga tggctgcaac     5499

taaactgaac aaatacctga cttttctttt accccattga aaatagtact ttcttcgttt     5559

cacaaattaa aaaaaaaatc tggtatcaac ccacattttg gctgtctagt attcatttac     5619

atttagggtt caccaggact aatgattttt ataaaccgtt ttctggggtg taccaaaaac     5679

atttgaatag gtttagaata gctagaatag ttccttgact ttcctcgaat ttcattaccc     5739

tctcagcatg cttgcagaga gctgggtggg ctcattcttg cagtcatact gcttatttag     5799

tgctgtattt tttaaacgtt tctgttcaga gaacttgctt aatcttccat atattctgct     5859

cagggcactt gcaattatta ggttttgttt ttctttttgt tttttagcct ttgatggtaa     5919

gaggaatacg ggctgccaca tagactttgt tctcattaat atcactattt acaactcatg     5979

tggactcaga aaaacacaca ccaccttttg gcttacttcg agtattgaat tgactggatc     6039

cactaaacca acactaagat gggaaaacac acatggtttg gagcaatagg aacatcatca     6099

taatttttgt ggttctattt caggtatagg aattataaaa taattggttc tttctaaaca     6159

cttgtcccat ttcattctct tgctttttta gcatgtgcaa tactttctgt gccaatagag     6219

tctgaccagt gtgctatata gttaaagctc attccctttt ggctttttcc ttgtttggtt     6279

gatcttcccc attctggcca gagcagggct ggagggaagg agccaggagg gagagagcct     6339

cccacctttc ccctgctgcg gatgctgagt gctggggcgg ggagccttca ggagccccgt     6399

gcgtctgccg ccacgttgca gaaagagcca gccaaggaga cccgggggag gaaccgcagt     6459

gtcccctgtc accacacgga atagtgaatg tggagtgtgg agaggaagga ggcagattca     6519

tttctaagac gcactctgga gccatgtagc ctggagtcaa cccattttcc acggtctttt     6579

ctgcaagtgg gcaggcccct cctcggggtc tgtgtccttg agacttggag ccctgcctct     6639

gagcctggac gggaagtgtg gcctgttgtg tgtgtgcgtt ctgagcgtgt tggccagtgg     6699

ctgtggaggg gaccacctgc cacccacggt caccactccc ttgtggcagc tttctcttca     6759

aataggaaga acgcacagag ggcaggagcc tcctgtttgc agacgttggc gggccccgag     6819

gctcccagag cagcctctgt caccgcttct gtgtagcaaa cattaacgat gacaggggta     6879

gaaattcttc ggtgccgttc agcttacaag gatcagccat gtgcctctgt actatgtcca     6939

ctttgcaata tttaccgaca gccgtctttt gttctttctt tcctgttttc catttttaaa     6999

ctagtaacag caggcctttt gcgtttacaa tggaacacaa tcaccaagaa attagtcagg     7059

gcgaaaagaa aaaaataata ctattaataa gaaaccaaca aacaagaacc tctctttcta     7119

gggatttcta aatatataaa atgactgttc cttagaatgt ttaacttaag aattatttca     7179

gtttgtctgg gccacactgg ggcagagggg ggagggaggg atacagagat ggatgccact     7239

tacctcagat cttttaaagt ggaaatccaa attgaatttt catttggact ttcaggataa     7299

ttttctatgt tggtcaactt ttcgttttcc ctaactcacc cagtttagtt tgggatgatt     7359

tgatttctgt tgttgttgat cccatttcta acttggaatt gtgagcctct atgttttctg     7419

ttaggtgagt gtgttgggtt ttttcccccc accaggaagt ggcagcatcc ctccttctcc     7479

cctaaaggga ctctgcggaa cctttcacac ctctttctca gggacggggc aggtgtgtgt     7539

gtggtacact gacgtgtcca gaagcagcac tttgactgct ctggagtagg gttgtacaat     7599

ttcaaggaat gtttggattt cctgcatctt gtggattact ccttagatac cgcatagatt     7659

gcaatataat gctgcatgtt caagatgaac agtagctcct agtaatcata aaatccactc     7719

tttgcacagt ttgatcttta ctgaaatatg ttgccaaaat ttatttttgt tgttgtagct     7779

ctggattttg ttttgttttg ttttttaagg aaacgattga caataccctt taacatctgt     7839

gactactaag gaaacctatt tctttcatag agagaaaaat ctccaatgct tttgaagaca     7899

ctaataccgt gctatttcag atatgggtga ggaagcagag ctctcggtac cgaaggccgg     7959

gcttcttgag ctgtgttggt tgtcatggct actgtttcat gaaccacaag cagctcaaca     8019

gactggtctg ttgccttctg aaaccctttg cacttcaatt tgcaccaggt gaaaacaggg     8079

ccagcagact ccatggccca attcggtttc ttcggtggtg atgtgaaagg agagaattac     8139

actttttttt tttttaagtg gcgtggaggc ctttgcttcc acatttgttt ttaacccaga     8199

atttctgaaa tagagaattt aagaacacat caagtaataa atatacagag aatatacttt     8259

tttataaagc acatgcatct gctattgtgt tgggttggtt tcctctcttt tccacggaca     8319

gtgttgtgtt tctggcatag ggaaactcca aacaacttgc acacctctac tccggagctg     8379

agatttcttt tacatagatg acctcgcttc aaatacgtta ccttactgat gataggatct     8439

tttcttgtag cactatacct tgtgggaatt tttttttaaa tgtacacctg atttgagaag     8499

ctgaagaaaa caaaattttg aagcactcac tttgaggagt acaggtaatg ttttaaaaaa     8559

ttgcacaaaa gaaaaatgaa tgtcgaaatg attcattcag tgtttgaaag atatggctct     8619

gttgaaacaa tgagtttcat actttgtttg taaaaaaaaa aaagcagaga agggttgaaa     8679

gttacatgtt tttttgtata tagaaatttg tcatgtctaa atgatcagat ttgtatggtt     8739

atggcctgga agaattacta cgtaaaaggc tcttaaacta tacctatgct tattgttatt     8799

tttgttacat atagccctcg tctgagggag gggaactcgg tattctgcga tttgagaata     8859

ctgttcattc ctatgctgaa agtacttctc tgagctccct tcttagtcta aactcttaag     8919

ccattgcaac ttctttttct tcagagatga tgtttgacat tttcagcact tcctgttcct     8979

ataaacccaa agaatataat cttgaacacg aagtgtttgt aacaagggat ccaggctacc     9039

aatcaaacag gactcattat ggggacaaaa aaaaaaatta tttcaccttc tttcccccca     9099

cacctcattt aaatgggggg agtaaaaaca tgatttcaat gtaaatgcct cattttattt     9159

tagttttatt ttgattttta tttaatataa agaggccaga ataaatacgg agcatcttct     9219

cagaatagta ttcctgtcca aaaatcaagc cggacagtgg aaactggaca gctgtgggga     9279

tattaagcac ccccacttac aattcttaaa ttcagaatct cgtcccctcc cttctcgttg     9339

aaggcaactg ttctggtagc taactttctc ctgtgtaatg gcgggaggga acaccggctt     9399

cagtttttca tgtccccatg acttgcatac aaatggttca actgtattaa aattaagtgc     9459

atttggccaa taggtagtat ctatacaata acaacaatct ctaagaattt ccataacttt     9519

tcttatctga aaggactcaa gtcttccact gcagatacat tggaggcttc acccacgttt     9579

tctttccctt tagtttgttt gctgtctgga tggccaatga gcctgtctcc ttttctgtgg     9639

ccaatctgaa ggccttcgtt ggaagtgttg tttacagtaa tccttaccaa gataacatac     9699

tgtcctccag aataccaagt attaggtgac actagctcaa gctgttgtct tcagagcagt     9759

taccaagaag ctcggtgcac aggttttctc tggttcttac aggaaccacc tactctttca     9819

gttttctggc ccaggagtgg ggtaaatcct ttagttagtg catttgaact tgatacctgt     9879

gcattcagtt ctgtgaatac tgcccttttt ggcggggttt cctcatctcc ccagcctgaa     9939

ctgctcaact ctaaacccaa attagtgtca gccgaaagga ggtttcaaga tagtcctgtc     9999

agtatttgtg gtgaccttca gattagacag tcttcatttc cagccagtgg agtcctggct    10059

ccagagccat ctctgagact cgtactactg gatgttttaa tatcagatca ttacccacca    10119

tatgcctccc acaggccaag ggaaaacaga caccagaact tgggttgagg gcactaccag    10179

actgacatgg ccagtacaga ggagaactag ggaaggaatg atgttttgca ccttattgaa    10239

aagaaaattt taagtgcata cataatagtt aagagctttt attgtgacag gagaactttt    10299

ttccatatgc gtgcatactc tctgtaattc cagtgtaaaa tattgtactt gcactagctt    10359

ttttaaacaa atattaaaaa atggaagaat tcatattcta ttttctaatc gtggtgtgtc    10419

tatttgtagg atacactcga gtctgtttat tgaattttat ggtccctttc tttgatggtg    10479

cttgcaggtt ttctaggtag aaattatttc attattataa taaaacaatg tttgattcaa    10539

aatttgaaca aaattgtttt aaataaattg tctgtatacc agtacaagtt tattgtttca    10599

gtatactcgt actaataaaa taacagtgcc aattgca                             10636


<210>  112
<211>  815
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Lys Ser Asn Gln Glu Arg Ser Asn Glu Cys Leu Pro Pro Lys Lys 
1               5                   10                  15      


Arg Glu Ile Pro Ala Thr Ser Arg Ser Ser Glu Glu Lys Ala Pro Thr 
            20                  25                  30          


Leu Pro Ser Asp Asn His Arg Val Glu Gly Thr Ala Trp Leu Pro Gly 
        35                  40                  45              


Asn Pro Gly Gly Arg Gly His Gly Gly Gly Arg His Gly Pro Ala Gly 
    50                  55                  60                  


Thr Ser Val Glu Leu Gly Leu Gln Gln Gly Ile Gly Leu His Lys Ala 
65                  70                  75                  80  


Leu Ser Thr Gly Leu Asp Tyr Ser Pro Pro Ser Ala Pro Arg Ser Val 
                85                  90                  95      


Pro Val Ala Thr Thr Leu Pro Ala Ala Tyr Ala Thr Pro Gln Pro Gly 
            100                 105                 110         


Thr Pro Val Ser Pro Val Gln Tyr Ala His Leu Pro His Thr Phe Gln 
        115                 120                 125             


Phe Ile Gly Ser Ser Gln Tyr Ser Gly Thr Tyr Ala Ser Phe Ile Pro 
    130                 135                 140                 


Ser Gln Leu Ile Pro Pro Thr Ala Asn Pro Val Thr Ser Ala Val Ala 
145                 150                 155                 160 


Ser Ala Ala Gly Ala Thr Thr Pro Ser Gln Arg Ser Gln Leu Glu Ala 
                165                 170                 175     


Tyr Ser Thr Leu Leu Ala Asn Met Gly Ser Leu Ser Gln Thr Pro Gly 
            180                 185                 190         


His Lys Ala Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        195                 200                 205             


His Gln His Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln His Leu Ser Arg Ala Pro Gly Leu Ile Thr Pro Gly Ser Pro Pro 
225                 230                 235                 240 


Pro Ala Gln Gln Asn Gln Tyr Val His Ile Ser Ser Ser Pro Gln Asn 
                245                 250                 255     


Thr Gly Arg Thr Ala Ser Pro Pro Ala Ile Pro Val His Leu His Pro 
            260                 265                 270         


His Gln Thr Met Ile Pro His Thr Leu Thr Leu Gly Pro Pro Ser Gln 
        275                 280                 285             


Val Val Met Gln Tyr Ala Asp Ser Gly Ser His Phe Val Pro Arg Glu 
    290                 295                 300                 


Ala Thr Lys Lys Ala Glu Ser Ser Arg Leu Gln Gln Ala Ile Gln Ala 
305                 310                 315                 320 


Lys Glu Val Leu Asn Gly Glu Met Glu Lys Ser Arg Arg Tyr Gly Ala 
                325                 330                 335     


Pro Ser Ser Ala Asp Leu Gly Leu Gly Lys Ala Gly Gly Lys Ser Val 
            340                 345                 350         


Pro His Pro Tyr Glu Ser Arg His Val Val Val His Pro Ser Pro Ser 
        355                 360                 365             


Asp Tyr Ser Ser Arg Asp Pro Ser Gly Val Arg Ala Ser Val Met Val 
    370                 375                 380                 


Leu Pro Asn Ser Asn Thr Pro Ala Ala Asp Leu Glu Val Gln Gln Ala 
385                 390                 395                 400 


Thr His Arg Glu Ala Ser Pro Ser Thr Leu Asn Asp Lys Ser Gly Leu 
                405                 410                 415     


His Leu Gly Lys Pro Gly His Arg Ser Tyr Ala Leu Ser Pro His Thr 
            420                 425                 430         


Val Ile Gln Thr Thr His Ser Ala Ser Glu Pro Leu Pro Val Gly Leu 
        435                 440                 445             


Pro Ala Thr Ala Phe Tyr Ala Gly Thr Gln Pro Pro Val Ile Gly Tyr 
    450                 455                 460                 


Leu Ser Gly Gln Gln Gln Ala Ile Thr Tyr Ala Gly Ser Leu Pro Gln 
465                 470                 475                 480 


His Leu Val Ile Pro Gly Thr Gln Pro Leu Leu Ile Pro Val Gly Ser 
                485                 490                 495     


Thr Asp Met Glu Ala Ser Gly Ala Ala Pro Ala Ile Val Thr Ser Ser 
            500                 505                 510         


Pro Gln Phe Ala Ala Val Pro His Thr Phe Val Thr Thr Ala Leu Pro 
        515                 520                 525             


Lys Ser Glu Asn Phe Asn Pro Glu Ala Leu Val Thr Gln Ala Ala Tyr 
    530                 535                 540                 


Pro Ala Met Val Gln Ala Gln Ile His Leu Pro Val Val Gln Ser Val 
545                 550                 555                 560 


Ala Ser Pro Ala Ala Ala Pro Pro Thr Leu Pro Pro Tyr Phe Met Lys 
                565                 570                 575     


Gly Ser Ile Ile Gln Leu Ala Asn Gly Glu Leu Lys Lys Val Glu Asp 
            580                 585                 590         


Leu Lys Thr Glu Asp Phe Ile Gln Ser Ala Glu Ile Ser Asn Asp Leu 
        595                 600                 605             


Lys Ile Asp Ser Ser Thr Val Glu Arg Ile Glu Asp Ser His Ser Pro 
    610                 615                 620                 


Gly Val Ala Val Ile Gln Phe Ala Val Gly Glu His Arg Ala Gln Val 
625                 630                 635                 640 


Ser Val Glu Val Leu Val Glu Tyr Pro Phe Phe Val Phe Gly Gln Gly 
                645                 650                 655     


Trp Ser Ser Cys Cys Pro Glu Arg Thr Ser Gln Leu Phe Asp Leu Pro 
            660                 665                 670         


Cys Ser Lys Leu Ser Val Gly Asp Val Cys Ile Ser Leu Thr Leu Lys 
        675                 680                 685             


Asn Leu Lys Asn Gly Ser Val Lys Lys Gly Gln Pro Val Asp Pro Ala 
    690                 695                 700                 


Ser Val Leu Leu Lys His Ser Lys Ala Asp Gly Leu Ala Gly Ser Arg 
705                 710                 715                 720 


His Arg Tyr Ala Glu Gln Glu Asn Gly Ile Asn Gln Gly Ser Ala Gln 
                725                 730                 735     


Met Leu Ser Glu Asn Gly Glu Leu Lys Phe Pro Glu Lys Met Gly Leu 
            740                 745                 750         


Pro Ala Ala Pro Phe Leu Thr Lys Ile Glu Pro Ser Lys Pro Ala Ala 
        755                 760                 765             


Thr Arg Lys Arg Arg Trp Ser Ala Pro Glu Ser Arg Lys Leu Glu Lys 
    770                 775                 780                 


Ser Glu Asp Glu Pro Pro Leu Thr Leu Pro Lys Pro Ser Leu Ile Pro 
785                 790                 795                 800 


Gln Glu Val Lys Ile Cys Ile Glu Gly Arg Ser Asn Val Gly Lys 
                805                 810                 815 


<210>  113
<211>  4683
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (330)..(1178)

<400>  113
ctctatggtt cggcggctct aagcgctcag ctccgcggtc gtcctccagg tctgtgccgc       60

ctccttccgg tctcggtggc gcggcacgcg cggctctcta ggcctccttc agctctgtgg      120

tgacggtggc cgaggtggag ggccggtctg aagagtggcg ggactggctt cacttcctcc      180

gcggttcctc ggagccgcct cgctcctctt cagggacttt gctgagaagg gctctcgggc      240

gtccagaccc caccgcaaag gtgtttggcg atccgccgag aagttgttgg ccccaggagc      300

atccctcggg gccgaatgcg cagtggacg atg ccc ctt ctg acc caa cag atc        353
                                Met Pro Leu Leu Thr Gln Gln Ile           
                                1               5                         

caa gac gag gat gat cag tac agc ctt gtg gcc agc ctt gac aac gtt        401
Gln Asp Glu Asp Asp Gln Tyr Ser Leu Val Ala Ser Leu Asp Asn Val           
    10                  15                  20                            

agg aat ctc tcc act atc ttg aaa gct att cat ttc cga gaa cat gcc        449
Arg Asn Leu Ser Thr Ile Leu Lys Ala Ile His Phe Arg Glu His Ala           
25                  30                  35                  40            

acg tgt ttc gca act aaa aat ggt atc aaa gta aca gtg gaa aat gca        497
Thr Cys Phe Ala Thr Lys Asn Gly Ile Lys Val Thr Val Glu Asn Ala           
                45                  50                  55                

aag tgt gtg caa gca aat gct ttt att cag gct gga ata ttt cag gag        545
Lys Cys Val Gln Ala Asn Ala Phe Ile Gln Ala Gly Ile Phe Gln Glu           
            60                  65                  70                    

ttt aaa gtt cag gaa gag tct gtt act ttt cga att aat tta act gtc        593
Phe Lys Val Gln Glu Glu Ser Val Thr Phe Arg Ile Asn Leu Thr Val           
        75                  80                  85                        

ctt tta gac tgt tta tct att ttt gga tca agt cct atg cca ggg act        641
Leu Leu Asp Cys Leu Ser Ile Phe Gly Ser Ser Pro Met Pro Gly Thr           
    90                  95                  100                           

tta act gca ctt cga atg tgt tac caa ggt tat ggt tac cct ttg atg        689
Leu Thr Ala Leu Arg Met Cys Tyr Gln Gly Tyr Gly Tyr Pro Leu Met           
105                 110                 115                 120           

ctg ttc ctg gaa gaa gga gga gtg gtg aca gtc tgc aaa atc aat aca        737
Leu Phe Leu Glu Glu Gly Gly Val Val Thr Val Cys Lys Ile Asn Thr           
                125                 130                 135               

cag gaa cct gag gag acc ctg gac ttt gat ttc tgc agc acc aat gtt        785
Gln Glu Pro Glu Glu Thr Leu Asp Phe Asp Phe Cys Ser Thr Asn Val           
            140                 145                 150                   

att aat aaa att att ctg cag tca gag ggg ctc cgt gaa gca ttt tct        833
Ile Asn Lys Ile Ile Leu Gln Ser Glu Gly Leu Arg Glu Ala Phe Ser           
        155                 160                 165                       

gaa ttg gat atg acg agt gaa gtc cta caa att acc atg tct cct gac        881
Glu Leu Asp Met Thr Ser Glu Val Leu Gln Ile Thr Met Ser Pro Asp           
    170                 175                 180                           

aag cct tat ttc agg tta tct act ttt gga aat gca gga agt tcc cac        929
Lys Pro Tyr Phe Arg Leu Ser Thr Phe Gly Asn Ala Gly Ser Ser His           
185                 190                 195                 200           

ctt gac tat ccc aaa gat tct gat ttg atg gaa gca ttt cat tgt aat        977
Leu Asp Tyr Pro Lys Asp Ser Asp Leu Met Glu Ala Phe His Cys Asn           
                205                 210                 215               

cag acc caa gtc aac aga tac aag att tcc tta ctg aaa ccc tct aca       1025
Gln Thr Gln Val Asn Arg Tyr Lys Ile Ser Leu Leu Lys Pro Ser Thr           
            220                 225                 230                   

aag gca tta gtc cta tct tgt aag gta tct att cgg aca gat aac aga       1073
Lys Ala Leu Val Leu Ser Cys Lys Val Ser Ile Arg Thr Asp Asn Arg           
        235                 240                 245                       

ggc ttc ctt tca tta cag tat atg att aga aat gaa gat gga caa ata       1121
Gly Phe Leu Ser Leu Gln Tyr Met Ile Arg Asn Glu Asp Gly Gln Ile           
    250                 255                 260                           

tgt ttt gtg gaa tat tac tgc tgc cct gat gaa gaa gtt cct gaa tct       1169
Cys Phe Val Glu Tyr Tyr Cys Cys Pro Asp Glu Glu Val Pro Glu Ser           
265                 270                 275                 280           

gag tct tga gtatgacaat tcactgatat ttatgtgtac atttatgata               1218
Glu Ser                                                                   
                                                                          

gatgaagttc ttattctgag tacagtactc tttgtcattt catattggat tttctataga     1278

gaagaagcac aatggggaag ataggagcaa ggtcatgtac cctaatagtt actatgtttt     1338

gtaaatccat tttgtagagg gcatgtaaat aaatgttttc ctgtagtcat agattattca     1398

ggactgtcct ttagttctgt cttttgaact catgggaata attgtgagtc agcgtaacat     1458

ttcaagagtc taaaggtggc cgggtgtggt ggctttaatc ccagcacttt gggaagccga     1518

ggtgggcgga tcacctgagg tcaggagttc gagaccagcc tgaccaacgt ggagaaaccc     1578

catctctact aaaaatacaa aaaattagcc ggacgtggtg gcacatgcct gtaatgccag     1638

ctactcggga ggctgaggca ggagaattgc ttgaacccgg gaggcggagg ttgtggtgag     1698

ctgagatgac gccattgcac tccagcctag gcaataagag caaaactctg cctcaaaaaa     1758

aaaaaaaaaa aaagtctaaa ggcttaaagt ttgatgcagc tacctgaaat gatcttttat     1818

ttatttatta ttagaaaaag caaaggcata tgggcattgc ttattagttt gaattctaga     1878

gactagatct taaagtagtg gttctcaaag tgttgtgccc gcaccaacat cagaatggcc     1938

tgcaaacttg tagcaaactc tggggaggag gccagcattc tgtattttaa caagcttccc     1998

tcaggagatt ctgatgcctg ctaaattttg ggaaccactg ttttaaagga aacttttttt     2058

ttctttaata gcatttaatt gtatgagatg attgctttta catgtgattt ccttgcaaat     2118

gttctgaagt tgaggcatca ccaaacaagt ctgaacaatt ctttatgtga tttattttta     2178

aagtagacct tttgaagaga tctatgaatg ggatataaag caattttcag tgttacaggt     2238

tttcttcttc ttctcaaaac tgtttgctgt aagtaactgc aatcagtact tactactttc     2298

catttgctta tgagtttctt gacaaatcaa ggtgtagaaa accagttatt aagtgatttt     2358

gtactttcct ggtagttgtc actaaaataa tttttgtggc atataaatat atttaataaa     2418

atgcaaaaat tatcttcctg tctagtagaa aaaattacat gagtaaagtg aagcttctgt     2478

ctttgttact gtaccaggtg acaacagctg agtgtccctc catggacagt cactattggc     2538

cttttgagtg agacagttct ttaggataaa aacctgtcat cccattgcag gattcattta     2598

gcctttctgg cccttaccca ctgatgctag tcattgtgac caccccacct cccccaaata     2658

aaagtgtgcc aaactattca ttgttgagaa ccattcaatt gtattcacca aaattggagg     2718

atatattgga atgccctacc ttaatatagg tcacatagca ttagagaaaa ttggtttgga     2778

gagtattaca gcaaagtgtg ctgcaaggag gctactccag cacaatggca ggcactgctt     2838

cccaggcata tggacaattc tgggaggtgg ccagggtcag cacctgataa ctagtaagtg     2898

tctcaatctc agcatacaaa atttagcagt gactacaaaa gaagttggaa ttttctaaaa     2958

tgtttgtatt caagaaggaa acaaatgaat ttactaaatg ttgtcagagt attttttgtt     3018

tagataacca ccaagaacag aacaaaccta aaagatactt gggaaaatat ctaatcagtc     3078

aacattctaa ggactgttaa atgtgaaata gcatagttat tttttgtctt ttgttactag     3138

tgtgaacaaa gaacggcgcc taacatataa tgggcattta gtaactctgt tagatgaaag     3198

actctccaat ttcagatttt cttttagcat cttattagtc actacttaat tctgatgatt     3258

tagctctaaa tttattttga tctcagtttt tttattttta tttttggaga caagatcttg     3318

ctctgttgcc caggctggag tacagttgta ggattacagt tcactccagc ctcaatctcc     3378

taggctcaag caatcctccc atctcagctt cccaaatagc tacgactaca ggtgcatgcc     3438

tccatgccct gctaattttt gtattttttg tagagatggg gttttactat gttccctagg     3498

ctaatcttga actcctgagc tcaagcaatc cacccgcctc ggcctcccaa agggctggga     3558

ttacaggcgt gagctatcat gcctggccta atgtattttt taaaagttga atctaaaaag     3618

aatttaaaac aaatataaat cagctcagta aggatggata tttttgtaca tttaaaacta     3678

ttattttagg ccgggagtgg tggctcacac ctgtaatccc agcattttgg gaagccgagg     3738

cagggggatc atctgaggtc aggaagttcg agatcagcct ggccaacatg gtgaaacccc     3798

tacctctact aaaaatacaa aaattagctg ggtgtggtgg tgggtgtctg taatcccagc     3858

tacttgagag gctgaggcaa gagaatcact tgaaactgga aggcgggggt tgcagtgagc     3918

cgagattgca ccattgcact ccagcctggg tgacagagca agactccgtc tcaaaaacaa     3978

aaaaaattaa aataaaaatt attgttttag ctgcatgtct tcagctattt agaattcaaa     4038

gactaatgaa ttgtttctaa gtcaccctaa catcaaggta cttattttat aaagaatttc     4098

ctccttattt gtgttctaat tgacccagga atttttactt taataaaagt ttaactttat     4158

ttcctatgga aaatcactag ggggagtgct ccctcaggca gagcaggcga cactttggtg     4218

ccactacaaa ttgatgtgta gtatatagaa gaatacagtc ttatatttaa agacttttag     4278

ttctgtcttt ttgaagttta tctctctttc tagtaaaatg gtgcttactg tgaatggata     4338

atcttttttt tcatttttca tttgttgatt tcccattcga tgatgtagtg cttccaccga     4398

gaattgatga aatgcttcaa aataataaaa gtatttgtta aattccactt taataaaaat     4458

aaggcatgta acacagtcat tttaacagga agccacaggg tttctgtggt gttaccaaag     4518

tcctagtaaa aattaattaa aattgctaaa agggcagaat gtggcactct caacagtggg     4578

gtaggcagtc cttcagaaca tagagacttc cttctttcct tccctgtctt cacattgctt     4638

gtcccttatc cccacctgaa ataaaatcta ttgggtcctg agaaa                     4683


<210>  114
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Pro Leu Leu Thr Gln Gln Ile Gln Asp Glu Asp Asp Gln Tyr Ser 
1               5                   10                  15      


Leu Val Ala Ser Leu Asp Asn Val Arg Asn Leu Ser Thr Ile Leu Lys 
            20                  25                  30          


Ala Ile His Phe Arg Glu His Ala Thr Cys Phe Ala Thr Lys Asn Gly 
        35                  40                  45              


Ile Lys Val Thr Val Glu Asn Ala Lys Cys Val Gln Ala Asn Ala Phe 
    50                  55                  60                  


Ile Gln Ala Gly Ile Phe Gln Glu Phe Lys Val Gln Glu Glu Ser Val 
65                  70                  75                  80  


Thr Phe Arg Ile Asn Leu Thr Val Leu Leu Asp Cys Leu Ser Ile Phe 
                85                  90                  95      


Gly Ser Ser Pro Met Pro Gly Thr Leu Thr Ala Leu Arg Met Cys Tyr 
            100                 105                 110         


Gln Gly Tyr Gly Tyr Pro Leu Met Leu Phe Leu Glu Glu Gly Gly Val 
        115                 120                 125             


Val Thr Val Cys Lys Ile Asn Thr Gln Glu Pro Glu Glu Thr Leu Asp 
    130                 135                 140                 


Phe Asp Phe Cys Ser Thr Asn Val Ile Asn Lys Ile Ile Leu Gln Ser 
145                 150                 155                 160 


Glu Gly Leu Arg Glu Ala Phe Ser Glu Leu Asp Met Thr Ser Glu Val 
                165                 170                 175     


Leu Gln Ile Thr Met Ser Pro Asp Lys Pro Tyr Phe Arg Leu Ser Thr 
            180                 185                 190         


Phe Gly Asn Ala Gly Ser Ser His Leu Asp Tyr Pro Lys Asp Ser Asp 
        195                 200                 205             


Leu Met Glu Ala Phe His Cys Asn Gln Thr Gln Val Asn Arg Tyr Lys 
    210                 215                 220                 


Ile Ser Leu Leu Lys Pro Ser Thr Lys Ala Leu Val Leu Ser Cys Lys 
225                 230                 235                 240 


Val Ser Ile Arg Thr Asp Asn Arg Gly Phe Leu Ser Leu Gln Tyr Met 
                245                 250                 255     


Ile Arg Asn Glu Asp Gly Gln Ile Cys Phe Val Glu Tyr Tyr Cys Cys 
            260                 265                 270         


Pro Asp Glu Glu Val Pro Glu Ser Glu Ser 
        275                 280         


<210>  115
<211>  1262
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (31)..(942)

<400>  115
cgcctctgac gccaccggct gggctccgcc atg agt tcg gcg ccg gcc tca ggc        54
                                 Met Ser Ser Ala Pro Ala Ser Gly          
                                 1               5                        

tcc gtg cgc gcg cgc tat ctt gtg tac ttc cag tac gtg ggc acc gac        102
Ser Val Arg Ala Arg Tyr Leu Val Tyr Phe Gln Tyr Val Gly Thr Asp           
    10                  15                  20                            

ttt aac ggg gtc gcg gcc gtc agg ggc act cag cgc gcc gtc ggg gtc        150
Phe Asn Gly Val Ala Ala Val Arg Gly Thr Gln Arg Ala Val Gly Val           
25                  30                  35                  40            

cag aac tac ctg gag gag gcc gcc gag cgg ctg aat tcc gtg gag ccg        198
Gln Asn Tyr Leu Glu Glu Ala Ala Glu Arg Leu Asn Ser Val Glu Pro           
                45                  50                  55                

gtc agg ttc acc atc tcc agc cgc acg gac gcc ggg gtc cac gcc ctg        246
Val Arg Phe Thr Ile Ser Ser Arg Thr Asp Ala Gly Val His Ala Leu           
            60                  65                  70                    

agc aac gcg gcg cac ctg gac gtc cag cgc cgc tca ggc cgg ccg ccc        294
Ser Asn Ala Ala His Leu Asp Val Gln Arg Arg Ser Gly Arg Pro Pro           
        75                  80                  85                        

ttc ccg ccc gag gtc ctg gcc gag gcc ctc aac aca cac ctg cgg cac        342
Phe Pro Pro Glu Val Leu Ala Glu Ala Leu Asn Thr His Leu Arg His           
    90                  95                  100                           

ccg gcc atc agg gtc ctg cgg gcc ttc cga gtg ccc agc gac ttc cac        390
Pro Ala Ile Arg Val Leu Arg Ala Phe Arg Val Pro Ser Asp Phe His           
105                 110                 115                 120           

gct cgt cac gca gcc acg tcc cgg acc tac ctg tac cgc ctg gcc act        438
Ala Arg His Ala Ala Thr Ser Arg Thr Tyr Leu Tyr Arg Leu Ala Thr           
                125                 130                 135               

ggc tgt cac cgg cgt gat gag ctg ccg gtg ttt gaa cgc aac cta tgc        486
Gly Cys His Arg Arg Asp Glu Leu Pro Val Phe Glu Arg Asn Leu Cys           
            140                 145                 150                   

tgg act ctc ccg gca gac tgc ctg gat atg gtc gcc atg cag gaa gcc        534
Trp Thr Leu Pro Ala Asp Cys Leu Asp Met Val Ala Met Gln Glu Ala           
        155                 160                 165                       

gcc cag cac ctc ctc ggc aca cac gac ttc agc gcc ttc cag tcc gct        582
Ala Gln His Leu Leu Gly Thr His Asp Phe Ser Ala Phe Gln Ser Ala           
    170                 175                 180                           

ggc agc ccg gtg ccg agc ccc gtg cga acg ctg cgc cgg gtc tcc gtt        630
Gly Ser Pro Val Pro Ser Pro Val Arg Thr Leu Arg Arg Val Ser Val           
185                 190                 195                 200           

tcc cca ggc caa gcc agc ccc ttg gtc acc ccc gag gag agc agg aag        678
Ser Pro Gly Gln Ala Ser Pro Leu Val Thr Pro Glu Glu Ser Arg Lys           
                205                 210                 215               

ctg cgg ttc tgg aac ctg gag ttt gag agc cag tct ttc ctg tat aga        726
Leu Arg Phe Trp Asn Leu Glu Phe Glu Ser Gln Ser Phe Leu Tyr Arg           
            220                 225                 230                   

cag gta cgg agg atg acg gct gtg ctg gtg gcc gtg ggg ctg ggg gct        774
Gln Val Arg Arg Met Thr Ala Val Leu Val Ala Val Gly Leu Gly Ala           
        235                 240                 245                       

ttg gca cct gcc cag gtg aag acg att ctg gag agc caa gat ccc ctg        822
Leu Ala Pro Ala Gln Val Lys Thr Ile Leu Glu Ser Gln Asp Pro Leu           
    250                 255                 260                           

ggc aag cac cag aca cgt gta gcc cca gcc cac ggc tta ttc ctc aag        870
Gly Lys His Gln Thr Arg Val Ala Pro Ala His Gly Leu Phe Leu Lys           
265                 270                 275                 280           

tca gtg ctg tac ggg aac ctc ggt gct gcc tcc tgc acc ctg cag ggg        918
Ser Val Leu Tyr Gly Asn Leu Gly Ala Ala Ser Cys Thr Leu Gln Gly           
                285                 290                 295               

cca cag ttc ggg agc cac gga tga ccctggacac tcaagccaaa gttaggccac       972
Pro Gln Phe Gly Ser His Gly                                               
            300                                                           

accaggccca accctgtgct ggtcaagcca gggcagtcac agctgcttgg ggcccacagc     1032

actgctgcct ggtctccaca gtagcctccc tgcccgggtc ccagcaccct ggatgcccgt     1092

ctctgtccca ggcgggatgg ggcacagtgc aggacacagc catgtacacc aagaagagag     1152

taccaagtag tcttttgttc agcttttact ggaaactgct gtctaggacc acctgcccta     1212

accaggaata aaggcaagac agcctggaaa aaaaaaaaaa aaaaaaaaaa                1262


<210>  116
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Ser Ser Ala Pro Ala Ser Gly Ser Val Arg Ala Arg Tyr Leu Val 
1               5                   10                  15      


Tyr Phe Gln Tyr Val Gly Thr Asp Phe Asn Gly Val Ala Ala Val Arg 
            20                  25                  30          


Gly Thr Gln Arg Ala Val Gly Val Gln Asn Tyr Leu Glu Glu Ala Ala 
        35                  40                  45              


Glu Arg Leu Asn Ser Val Glu Pro Val Arg Phe Thr Ile Ser Ser Arg 
    50                  55                  60                  


Thr Asp Ala Gly Val His Ala Leu Ser Asn Ala Ala His Leu Asp Val 
65                  70                  75                  80  


Gln Arg Arg Ser Gly Arg Pro Pro Phe Pro Pro Glu Val Leu Ala Glu 
                85                  90                  95      


Ala Leu Asn Thr His Leu Arg His Pro Ala Ile Arg Val Leu Arg Ala 
            100                 105                 110         


Phe Arg Val Pro Ser Asp Phe His Ala Arg His Ala Ala Thr Ser Arg 
        115                 120                 125             


Thr Tyr Leu Tyr Arg Leu Ala Thr Gly Cys His Arg Arg Asp Glu Leu 
    130                 135                 140                 


Pro Val Phe Glu Arg Asn Leu Cys Trp Thr Leu Pro Ala Asp Cys Leu 
145                 150                 155                 160 


Asp Met Val Ala Met Gln Glu Ala Ala Gln His Leu Leu Gly Thr His 
                165                 170                 175     


Asp Phe Ser Ala Phe Gln Ser Ala Gly Ser Pro Val Pro Ser Pro Val 
            180                 185                 190         


Arg Thr Leu Arg Arg Val Ser Val Ser Pro Gly Gln Ala Ser Pro Leu 
        195                 200                 205             


Val Thr Pro Glu Glu Ser Arg Lys Leu Arg Phe Trp Asn Leu Glu Phe 
    210                 215                 220                 


Glu Ser Gln Ser Phe Leu Tyr Arg Gln Val Arg Arg Met Thr Ala Val 
225                 230                 235                 240 


Leu Val Ala Val Gly Leu Gly Ala Leu Ala Pro Ala Gln Val Lys Thr 
                245                 250                 255     


Ile Leu Glu Ser Gln Asp Pro Leu Gly Lys His Gln Thr Arg Val Ala 
            260                 265                 270         


Pro Ala His Gly Leu Phe Leu Lys Ser Val Leu Tyr Gly Asn Leu Gly 
        275                 280                 285             


Ala Ala Ser Cys Thr Leu Gln Gly Pro Gln Phe Gly Ser His Gly 
    290                 295                 300             


<210>  117
<211>  2596
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (138)..(1163)

<400>  117
gcttcttctg cccggagagg acgtcatttc cgccgagtcc ctgacctgct gctaggatcg       60

cgacgggaac tggagcccga ggtccccgcg cggcccgggc ctggcgccct gaggggaaga      120

gcggcccggc ccgagcc atg acg gac ggg atc cta ggg aag gca gcc aca         170
                   Met Thr Asp Gly Ile Leu Gly Lys Ala Ala Thr            
                   1               5                   10                 

atg gag atc cct atc cac ggg aac ggc gaa gcc agg cag ctt cct gaa        218
Met Glu Ile Pro Ile His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu           
            15                  20                  25                    

gat gat ggg ctg gag cag gac ctc cag cag gtg atg gtg tca gga ccc        266
Asp Asp Gly Leu Glu Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro           
        30                  35                  40                        

aac ctc aat gaa acc agc att gtg tct ggt ggc tat ggg ggc tct ggt        314
Asn Leu Asn Glu Thr Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly           
    45                  50                  55                            

gat gga ctc atc ccc aca ggg tct ggc cgc cat cca tct cac agc acc        362
Asp Gly Leu Ile Pro Thr Gly Ser Gly Arg His Pro Ser His Ser Thr           
60                  65                  70                  75            

act cct tct ggc cct gga gat gag gtg gct cgg ggc att gct gga gaa        410
Thr Pro Ser Gly Pro Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu           
                80                  85                  90                

aag ttt gac atc gtc aag aaa tgg ggc atc aac acc tat aag tgc aca        458
Lys Phe Asp Ile Val Lys Lys Trp Gly Ile Asn Thr Tyr Lys Cys Thr           
            95                  100                 105                   

aag caa ctg tta tca gaa cga ttt ggt cga ggc tca cgg act gtg gac        506
Lys Gln Leu Leu Ser Glu Arg Phe Gly Arg Gly Ser Arg Thr Val Asp           
        110                 115                 120                       

ctg gag cta gag ctg cag att gag ttg ctg cgt gag acg aag cgc aag        554
Leu Glu Leu Glu Leu Gln Ile Glu Leu Leu Arg Glu Thr Lys Arg Lys           
    125                 130                 135                           

tat gag agt gtc ctg cag ctg ggc cgg gca ctg aca gcc cac ctc tac        602
Tyr Glu Ser Val Leu Gln Leu Gly Arg Ala Leu Thr Ala His Leu Tyr           
140                 145                 150                 155           

agc ctg ctg cag acc cag cat gca ctg ggt gat gcc ttt gct gac ctc        650
Ser Leu Leu Gln Thr Gln His Ala Leu Gly Asp Ala Phe Ala Asp Leu           
                160                 165                 170               

agc cag aag tcc cca gag ctt cag gag gaa ttt ggc tac aat gca gag        698
Ser Gln Lys Ser Pro Glu Leu Gln Glu Glu Phe Gly Tyr Asn Ala Glu           
            175                 180                 185                   

aca cag aaa cta cta tgc aag aat ggg gaa acg ctg cta gga gcc gtg        746
Thr Gln Lys Leu Leu Cys Lys Asn Gly Glu Thr Leu Leu Gly Ala Val           
        190                 195                 200                       

aac ttc ttt gtc tct agc atc aac aca ttg gtc acc aag acc atg gaa        794
Asn Phe Phe Val Ser Ser Ile Asn Thr Leu Val Thr Lys Thr Met Glu           
    205                 210                 215                           

gac acg ctc atg act gtg aaa cag tat gag gct gcc agg ctg gaa tat        842
Asp Thr Leu Met Thr Val Lys Gln Tyr Glu Ala Ala Arg Leu Glu Tyr           
220                 225                 230                 235           

gat gcc tac cga aca gac tta gag gag ctg agt cta ggc ccc cgg gat        890
Asp Ala Tyr Arg Thr Asp Leu Glu Glu Leu Ser Leu Gly Pro Arg Asp           
                240                 245                 250               

gca ggg aca cgt ggt cga ctt gag agt gcc cag gcc act ttc cag gcc        938
Ala Gly Thr Arg Gly Arg Leu Glu Ser Ala Gln Ala Thr Phe Gln Ala           
            255                 260                 265                   

cat cgg gac aag tat gag aag ctg cgg gga gat gtg gcc atc aag ctc        986
His Arg Asp Lys Tyr Glu Lys Leu Arg Gly Asp Val Ala Ile Lys Leu           
        270                 275                 280                       

aag ttc ctg gaa gaa aac aag atc aag gtg atg cac aag cag ctg ctg       1034
Lys Phe Leu Glu Glu Asn Lys Ile Lys Val Met His Lys Gln Leu Leu           
    285                 290                 295                           

ctc ttc cac aat gct gtg tcc gcc tac ttt gct ggg aac cag aaa cag       1082
Leu Phe His Asn Ala Val Ser Ala Tyr Phe Ala Gly Asn Gln Lys Gln           
300                 305                 310                 315           

ctg gag cag acc ctg cag cag ttc aac atc aag ctg cgg cct cca gga       1130
Leu Glu Gln Thr Leu Gln Gln Phe Asn Ile Lys Leu Arg Pro Pro Gly           
                320                 325                 330               

gct gag aaa ccc tcc tgg cta gag gag cag tga gctgctccca gcccaacttg     1183
Ala Glu Lys Pro Ser Trp Leu Glu Glu Gln                                   
            335                 340                                       

gctatcaaga aagacattgg gaagggcagc cccagggtgt gggagattgg acatggtaca     1243

tcctttgtca cttgccctct ggcttgggct cctttttctg gctggggcct gacaccagtt     1303

ttgcccacat tgctatggtg ggaagagggc ctggaggccc agaagttgct gccctgtcta     1363

tcttcctggc cacagggctt cattcccaga tcttttcctt ccacttcaca gccaacggct     1423

atgacaaaac cactccctgg ccaatggcat cactcttcag gctggggtgt gctccctgac     1483

caatgacaga gcctgaaaat gccctgtcag ccaatggcag ctcttctcgg actcccctgg     1543

gccaatgatg ttgcgtctaa taccctttgt ctctcctcta tgcgtgccca ttgcagagaa     1603

ggggactggg accaaagggg tggggataat ggggagcccc attgctggcc ttgcatctga     1663

ataggcctac cctcacccac ccacccagtt taattgtgct tagagcccaa gaagattggg     1723

atctagcact aggaataaac ctttcataaa agcaggccca gcgaggtcaa tttgtcgggg     1783

actctaggag ggtggcctgg gtggagacaa gctcagtcta atcaaacacc agaaccctat     1843

caagtcaaaa gagctggggc caggcagctg aagtcacagg tttcagagat ggtttgaagg     1903

cccagtcttc tctcccagcc tcagttggag ccaaagcttt gtcctttagc cagcaccaag     1963

atagctatgg atcttaagag caccagatcc agagggggtt gggtttgctg accttcatca     2023

tgcattcatt catacagcaa atatttactg agtgctttca tttgccaggg actgcgttag     2083

gccctgggga aacatcagtg aataaaacac ggtccctgcc cacagtgctt agggcctact     2143

gagggaaaga agtaaccagg caactacaaa acagtgataa gtattaggat acagaagtac     2203

agagggcgct gtgggagcac aaaggagggg catctggcat ggactggggt ggaaatgggg     2263

atgtcagttt gaaagctgag acctggccag gtgcggtggc tcactcctgt aatcccagca     2323

ctttgggagg ccgaggcggg cggatcacca ggtcaggaga tcaagaccat cctggctaac     2383

acggtgaaaa cccatctcta ctaaaaatgc aagaaaatta gcccggcacg gtggctggcg     2443

cctgtagtcc tgtagtccca gctactcggg aggctgaggc aggagaatgg tgtgaacccg     2503

ggaggcggag cttgcagtgg agccaagatt gcgccactgc actccagcct gggcaacaga     2563

gcgggactcc atctcaaaaa aaaaaaaaaa aaa                                  2596


<210>  118
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Thr Asp Gly Ile Leu Gly Lys Ala Ala Thr Met Glu Ile Pro Ile 
1               5                   10                  15      


His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu Asp Asp Gly Leu Glu 
            20                  25                  30          


Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro Asn Leu Asn Glu Thr 
        35                  40                  45              


Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro 
    50                  55                  60                  


Thr Gly Ser Gly Arg His Pro Ser His Ser Thr Thr Pro Ser Gly Pro 
65                  70                  75                  80  


Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu Lys Phe Asp Ile Val 
                85                  90                  95      


Lys Lys Trp Gly Ile Asn Thr Tyr Lys Cys Thr Lys Gln Leu Leu Ser 
            100                 105                 110         


Glu Arg Phe Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Leu 
        115                 120                 125             


Gln Ile Glu Leu Leu Arg Glu Thr Lys Arg Lys Tyr Glu Ser Val Leu 
    130                 135                 140                 


Gln Leu Gly Arg Ala Leu Thr Ala His Leu Tyr Ser Leu Leu Gln Thr 
145                 150                 155                 160 


Gln His Ala Leu Gly Asp Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro 
                165                 170                 175     


Glu Leu Gln Glu Glu Phe Gly Tyr Asn Ala Glu Thr Gln Lys Leu Leu 
            180                 185                 190         


Cys Lys Asn Gly Glu Thr Leu Leu Gly Ala Val Asn Phe Phe Val Ser 
        195                 200                 205             


Ser Ile Asn Thr Leu Val Thr Lys Thr Met Glu Asp Thr Leu Met Thr 
    210                 215                 220                 


Val Lys Gln Tyr Glu Ala Ala Arg Leu Glu Tyr Asp Ala Tyr Arg Thr 
225                 230                 235                 240 


Asp Leu Glu Glu Leu Ser Leu Gly Pro Arg Asp Ala Gly Thr Arg Gly 
                245                 250                 255     


Arg Leu Glu Ser Ala Gln Ala Thr Phe Gln Ala His Arg Asp Lys Tyr 
            260                 265                 270         


Glu Lys Leu Arg Gly Asp Val Ala Ile Lys Leu Lys Phe Leu Glu Glu 
        275                 280                 285             


Asn Lys Ile Lys Val Met His Lys Gln Leu Leu Leu Phe His Asn Ala 
    290                 295                 300                 


Val Ser Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu 
305                 310                 315                 320 


Gln Gln Phe Asn Ile Lys Leu Arg Pro Pro Gly Ala Glu Lys Pro Ser 
                325                 330                 335     


Trp Leu Glu Glu Gln 
            340     


<210>  119
<211>  2330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (30)..(794)

<400>  119
aaaggaccga ggcgtgcagc ggacagcag atg gat ccc gcg gcc agc agc tgc         53
                                Met Asp Pro Ala Ala Ser Ser Cys           
                                1               5                         

atg agg agc ctc cag ccc cca gcc cct gtc tgg ggc tgc ctt cga aac        101
Met Arg Ser Leu Gln Pro Pro Ala Pro Val Trp Gly Cys Leu Arg Asn           
    10                  15                  20                            

ccc cac tcg gaa ggc aat ggg gcc tca ggg cta ccc cac tac ccg ccc        149
Pro His Ser Glu Gly Asn Gly Ala Ser Gly Leu Pro His Tyr Pro Pro           
25                  30                  35                  40            

acc ccg ttc tcc ttc cac cag aaa cca gac ttc ctg gcg aca gcg acg        197
Thr Pro Phe Ser Phe His Gln Lys Pro Asp Phe Leu Ala Thr Ala Thr           
                45                  50                  55                

gca gcg tac cct gac ttc tca gcc tcc tgc ctg gca gcc acc cca cac        245
Ala Ala Tyr Pro Asp Phe Ser Ala Ser Cys Leu Ala Ala Thr Pro His           
            60                  65                  70                    

agc ctg ccc cag gag gag cac atc ttc act gag cag cac ccc gct ttc        293
Ser Leu Pro Gln Glu Glu His Ile Phe Thr Glu Gln His Pro Ala Phe           
        75                  80                  85                        

cca cag tcc ccc aac tgg cac ttc cct gtc tca gac gcc cgg cgc agg        341
Pro Gln Ser Pro Asn Trp His Phe Pro Val Ser Asp Ala Arg Arg Arg           
    90                  95                  100                           

ccc aac tca ggc ccg gca ggg ggt tcc aag gaa atg ggg acc agc agc        389
Pro Asn Ser Gly Pro Ala Gly Gly Ser Lys Glu Met Gly Thr Ser Ser           
105                 110                 115                 120           

ctg ggc ctg gtg gac acc aca gga ggc cca ggc gat gac tac ggg gtg        437
Leu Gly Leu Val Asp Thr Thr Gly Gly Pro Gly Asp Asp Tyr Gly Val           
                125                 130                 135               

ctt ggg agc act gcc aat gag aca gag aag aaa tca tcc agg cgg aga        485
Leu Gly Ser Thr Ala Asn Glu Thr Glu Lys Lys Ser Ser Arg Arg Arg           
            140                 145                 150                   

aag gag agt tca gac aac cag gag aac aga ggg aag ccg gag ggc agc        533
Lys Glu Ser Ser Asp Asn Gln Glu Asn Arg Gly Lys Pro Glu Gly Ser           
        155                 160                 165                       

agc aaa gcc cgc aag gag agg acg gcc ttc acc aag gag cag ctg cga        581
Ser Lys Ala Arg Lys Glu Arg Thr Ala Phe Thr Lys Glu Gln Leu Arg           
    170                 175                 180                           

gag ctg gag gca gag ttt gcc cat cat aac tac ctg act cgg ctc cgc        629
Glu Leu Glu Ala Glu Phe Ala His His Asn Tyr Leu Thr Arg Leu Arg           
185                 190                 195                 200           

aga tat gag att gcg gta aac ctg gac ctc tct gag cgc cag gtc aaa        677
Arg Tyr Glu Ile Ala Val Asn Leu Asp Leu Ser Glu Arg Gln Val Lys           
                205                 210                 215               

gtg tgg ttc cag aac cga agg atg aag tgg aag cgt gtg aag gga ggt        725
Val Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Arg Val Lys Gly Gly           
            220                 225                 230                   

cag ccc atc tcc ccc aat ggg cag gac cct gag gat ggg gac tcc aca        773
Gln Pro Ile Ser Pro Asn Gly Gln Asp Pro Glu Asp Gly Asp Ser Thr           
        235                 240                 245                       

gcc tct cca agt tca gag tga gattctgcat ggaggaaaaa tgactaagga           824
Ala Ser Pro Ser Ser Glu                                                   
    250                                                                   

ctgagccccc tacccaacta cccccacccc aatcccacct tcaccctctt ccttccccag      884

ccagggcagc ctctccacat ctttccctga ctcttggata tgaaactgcc cagcattcct      944

gggagtctta ggattttcta ggaagttctg tccagcctct tagcagcctc ttccctaggg     1004

cctttgctcc cacactctca tggaatcaga cagagatcct accgggccgg atgaatctgg     1064

aaacagcttc agagatactg cttctcagcg tctcttggct gccacccatg cctcctccta     1124

ccgctgttct cctaggtcag ccaggcctcc tcctggtctg gacaccacct ggcctggtgg     1184

gagaggagct ttggaaccag ctggcgactc ggaaagtaaa tgcttcaaaa ggaaggaaat     1244

gacagagaca cacgcccttg cccaccttcc tctgtaggct gcacatctga ggctttgggg     1304

ccccttagtt gtcccgaaac cccaagaaaa atcagaatga ggagagtcaa ggacagcaac     1364

tcagctgctg caagccagaa acacatccct gtctccaaat ttgttggcta agtggagaca     1424

cttctgagaa ctgactagag aagacagaaa aatagcccga tgtaggtttc ggtgtcccca     1484

tataggcccg tccacacagg cttgactggg tggacaagaa tgaacccatg acagcacctg     1544

ctgcttcaaa atcaaaatca atttagggat acagcagggg ctgttgggct gtgctccaga     1604

gaaaaggagc agctactcct tttaaatcca cgatttctgg attgaaaacc tgtccagatg     1664

ctgagttgtt gggctgaaca actaggagct gaaaacaacg tagaggctgg aaagtgtccc     1724

ctgcattctg gaggggaggg gagataataa ggagggctgc tgggtgaggg cctggagatg     1784

tggaaccctg gagtggaagg ttctccagtg acagtgtcct gtgactgcaa aaggggacaa     1844

gaaaatccct cttcctccat gggatggatt taagctcttg ctgtgtgttc tacaaatgct     1904

gttattgtgg gaggaaatgc taggtttttg tgtgtggact gcccagacct cagccaggtc     1964

ttctggagat gacatttgag gactgatggc caaagagcat gggggactga agccctggct     2024

gcctcagcgc tctgtctccc aacaccagct ggtgttgcag agggaggtca acgtgagttt     2084

ggatctcttg tacgcagatg taatcattca catgtaaaaa taaccccacc tccccacccc     2144

aaaaagggca agagctgtgg aaaatgattg ccaaatgaga tggctggtta gagcatgatt     2204

ttttctaaag catacttcat atattttctt aagattacat caagctaatt gtgcgagctc     2264

aattcacttt gtaagaaaac tctcggagaa ataaaatcaa taaaaagcaa aaaaaaaaaa     2324

aaaaaa                                                                2330


<210>  120
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Asp Pro Ala Ala Ser Ser Cys Met Arg Ser Leu Gln Pro Pro Ala 
1               5                   10                  15      


Pro Val Trp Gly Cys Leu Arg Asn Pro His Ser Glu Gly Asn Gly Ala 
            20                  25                  30          


Ser Gly Leu Pro His Tyr Pro Pro Thr Pro Phe Ser Phe His Gln Lys 
        35                  40                  45              


Pro Asp Phe Leu Ala Thr Ala Thr Ala Ala Tyr Pro Asp Phe Ser Ala 
    50                  55                  60                  


Ser Cys Leu Ala Ala Thr Pro His Ser Leu Pro Gln Glu Glu His Ile 
65                  70                  75                  80  


Phe Thr Glu Gln His Pro Ala Phe Pro Gln Ser Pro Asn Trp His Phe 
                85                  90                  95      


Pro Val Ser Asp Ala Arg Arg Arg Pro Asn Ser Gly Pro Ala Gly Gly 
            100                 105                 110         


Ser Lys Glu Met Gly Thr Ser Ser Leu Gly Leu Val Asp Thr Thr Gly 
        115                 120                 125             


Gly Pro Gly Asp Asp Tyr Gly Val Leu Gly Ser Thr Ala Asn Glu Thr 
    130                 135                 140                 


Glu Lys Lys Ser Ser Arg Arg Arg Lys Glu Ser Ser Asp Asn Gln Glu 
145                 150                 155                 160 


Asn Arg Gly Lys Pro Glu Gly Ser Ser Lys Ala Arg Lys Glu Arg Thr 
                165                 170                 175     


Ala Phe Thr Lys Glu Gln Leu Arg Glu Leu Glu Ala Glu Phe Ala His 
            180                 185                 190         


His Asn Tyr Leu Thr Arg Leu Arg Arg Tyr Glu Ile Ala Val Asn Leu 
        195                 200                 205             


Asp Leu Ser Glu Arg Gln Val Lys Val Trp Phe Gln Asn Arg Arg Met 
    210                 215                 220                 


Lys Trp Lys Arg Val Lys Gly Gly Gln Pro Ile Ser Pro Asn Gly Gln 
225                 230                 235                 240 


Asp Pro Glu Asp Gly Asp Ser Thr Ala Ser Pro Ser Ser Glu 
                245                 250                 


<210>  121
<211>  2033
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (156)..(719)

<400>  121
aagccgcaga ttcccatcca gtatcctaga ggaggagacc cagggctgtg tcctaggagg       60

cccaggaagc ctggtcagcc tggaggccga gggcgggccc gggagatctg ggaaggacat      120

cagtgtctcc acgaagagca gcagggtctc agccc atg gca gcc gca ggc ccc         173
                                       Met Ala Ala Ala Gly Pro            
                                       1               5                  

atg act ggg gcc gca gcc tcc aga gcc gcc aca gca gcc cat tgt tct        221
Met Thr Gly Ala Ala Ala Ser Arg Ala Ala Thr Ala Ala His Cys Ser           
            10                  15                  20                    

ggg ggg tca aag gtg gag gct gtc aga ggg gca gtg cag ggg gct gct        269
Gly Gly Ser Lys Val Glu Ala Val Arg Gly Ala Val Gln Gly Ala Ala           
        25                  30                  35                        

ggg gtg aag ccc cct gta gca gca gca ccc agc ctg ctg tgg ctc tgc        317
Gly Val Lys Pro Pro Val Ala Ala Ala Pro Ser Leu Leu Trp Leu Cys           
    40                  45                  50                            

cct cct gga ccc cct gtc ctc ctg gac ccc ctg ccc tcc tgg acc ctc        365
Pro Pro Gly Pro Pro Val Leu Leu Asp Pro Leu Pro Ser Trp Thr Leu           
55                  60                  65                  70            

tgc cct cct gga ccc cct tcc ctc ctg ggc cct cct gga ccc cct gcc        413
Cys Pro Pro Gly Pro Pro Ser Leu Leu Gly Pro Pro Gly Pro Pro Ala           
                75                  80                  85                

ctc ctg gat cct ctg tcc tcc tgg acc ccc tgc cct cct gga ccc cct        461
Leu Leu Asp Pro Leu Ser Ser Trp Thr Pro Cys Pro Pro Gly Pro Pro           
            90                  95                  100                   

gtc tgt ggc ccc tgc tcc tct cct cct tcc ccg aca cat gac tgg acc        509
Val Cys Gly Pro Cys Ser Ser Pro Pro Ser Pro Thr His Asp Trp Thr           
        105                 110                 115                       

ccc cga tct gca gcc ggg gtc tgg gca ctg ggg gtc ctg tgg gcc tct        557
Pro Arg Ser Ala Ala Gly Val Trp Ala Leu Gly Val Leu Trp Ala Ser           
    120                 125                 130                           

cgg tgt ctg ggg aca atc aca ggt tcc cgt gcc cac acc cag cct ctg        605
Arg Cys Leu Gly Thr Ile Thr Gly Ser Arg Ala His Thr Gln Pro Leu           
135                 140                 145                 150           

ctt cca gaa cac act aga ggg tcc cgg cat cct gat gag tcc act gtc        653
Leu Pro Glu His Thr Arg Gly Ser Arg His Pro Asp Glu Ser Thr Val           
                155                 160                 165               

ccc gcg atg gtt ttc agg gat gga gaa ggc tcc ctg tcc tcc gct gga        701
Pro Ala Met Val Phe Arg Asp Gly Glu Gly Ser Leu Ser Ser Ala Gly           
            170                 175                 180                   

acc ctg cag ccg ggc tga cggtaccccc accacccacc caggggcccc               749
Thr Leu Gln Pro Gly                                                       
        185                                                               

agaccctccc catctccacc gccaacccag gccccggctg cgcacgcggg gccaggccgt      809

gagctgctgt ccccggatgg ggccgccccg ggctggcctg gctcactccg tgtcacagat      869

attcccacag agaccccagc gagacctgca gaacattaca gcagaatgaa ggagagccag      929

aggaagaggc agatgtgctg gcctgtaaac agtctgattt ccaatgtaaa ccagattcag      989

gcccacgaca tcaggtaaac atctgcatca gagcccccgg ccccccaccg cccgggaggc     1049

cccggggtcc acacggccga ctctgggacc cgtcacagtg accgccgaga catttcgtaa     1109

ttaggcaaaa ttgatccttg cattccttcc ctaaatccca aatctctgca attttacttc     1169

ttctcaaaaa tgaaaacatt tggcaattag ctgatccaag tgaaaaaggt agagaatgtg     1229

ctctcaactg gaaaatgcca attaaggaag cagctctgac ttcccacccg ccctggctaa     1289

gctgggagct tatcttcccc gagaagaatc tgctgggata agggggcttg ggaaacaccg     1349

agggcagggc tgcctcctca gcttcctttg agagcagatt agccgtggcc ttgtgccagc     1409

agggcctggg tgccacacag ggtggcaggg gtggcagagc cgggcccggc tctggtactg     1469

ggatttgggg tggcgggacc cagtggggca cccgcttgtg ggcggcactg agggcggtga     1529

cgtaggcagc gggtgccggt gtctgcccct ccatctggcc gggctcccca ccctgctcct     1589

gcagccctgg acctcagggc ccatttgcgg tgcaaggcgg ctcttggcca ttttgcccgc     1649

agggccctac cttgggtctt gggagcttct gtcccttgcc ctctcttgtc caggtcagca     1709

tctcccactg tgggaatcct atgtggcccc atcgtctgga cagtgtgggt caggtcactg     1769

tggctgtttt gtgatgcgtg tgtgggctca tccctcagtg ctcagaagct gcagacacta     1829

tggaaccgct tttcaggccc cgtggccgtc acccccgctc tagagacttg attgcaggga     1889

ccatgcccgg ccggcctaac tgcacccctc actccaggtg ggtgggggga cccaggcctg     1949

ctggcccctg tggtggtgca gcccagaagg tgtgaatcag tttacactgt tcagtgcctg     2009

aataaaagtc acaggacaaa gagg                                            2033


<210>  122
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Ala Ala Ala Gly Pro Met Thr Gly Ala Ala Ala Ser Arg Ala Ala 
1               5                   10                  15      


Thr Ala Ala His Cys Ser Gly Gly Ser Lys Val Glu Ala Val Arg Gly 
            20                  25                  30          


Ala Val Gln Gly Ala Ala Gly Val Lys Pro Pro Val Ala Ala Ala Pro 
        35                  40                  45              


Ser Leu Leu Trp Leu Cys Pro Pro Gly Pro Pro Val Leu Leu Asp Pro 
    50                  55                  60                  


Leu Pro Ser Trp Thr Leu Cys Pro Pro Gly Pro Pro Ser Leu Leu Gly 
65                  70                  75                  80  


Pro Pro Gly Pro Pro Ala Leu Leu Asp Pro Leu Ser Ser Trp Thr Pro 
                85                  90                  95      


Cys Pro Pro Gly Pro Pro Val Cys Gly Pro Cys Ser Ser Pro Pro Ser 
            100                 105                 110         


Pro Thr His Asp Trp Thr Pro Arg Ser Ala Ala Gly Val Trp Ala Leu 
        115                 120                 125             


Gly Val Leu Trp Ala Ser Arg Cys Leu Gly Thr Ile Thr Gly Ser Arg 
    130                 135                 140                 


Ala His Thr Gln Pro Leu Leu Pro Glu His Thr Arg Gly Ser Arg His 
145                 150                 155                 160 


Pro Asp Glu Ser Thr Val Pro Ala Met Val Phe Arg Asp Gly Glu Gly 
                165                 170                 175     


Ser Leu Ser Ser Ala Gly Thr Leu Gln Pro Gly 
            180                 185         


<210>  123
<211>  810
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (6)..(401)

<400>  123
ccacc atg gac ccc cgt ctg ccc gcc tgg gcg ctg gtg ctg ctg ggc cct       50
      Met Asp Pro Arg Leu Pro Ala Trp Ala Leu Val Leu Leu Gly Pro         
      1               5                   10                  15          

gcc ctg gtg ttc gcg ttg ggc ccc gcg ccc acc cca gag atg cgt gag         98
Ala Leu Val Phe Ala Leu Gly Pro Ala Pro Thr Pro Glu Met Arg Glu           
                20                  25                  30                

aag ttg tgc ggc cac cac ttc gta cgc gcg cta gtg cgc gtg tgc ggg        146
Lys Leu Cys Gly His His Phe Val Arg Ala Leu Val Arg Val Cys Gly           
            35                  40                  45                    

ggc ccc cgc tgg tcc acc gaa gcc agg agg cct gcg acc gga ggc gac        194
Gly Pro Arg Trp Ser Thr Glu Ala Arg Arg Pro Ala Thr Gly Gly Asp           
        50                  55                  60                        

cgt gag ttg cta cag tgg ctg gag aga cga cat ctg ctc cat ggg ctg        242
Arg Glu Leu Leu Gln Trp Leu Glu Arg Arg His Leu Leu His Gly Leu           
    65                  70                  75                            

gtg gcc gac agt aat ctc acg ctg gga cct ggc ctg cag ccc ctg ccc        290
Val Ala Asp Ser Asn Leu Thr Leu Gly Pro Gly Leu Gln Pro Leu Pro           
80                  85                  90                  95            

cag acc tct cac cat cac cgc cac cac cgt gca gct gcc acc aac cct        338
Gln Thr Ser His His His Arg His His Arg Ala Ala Ala Thr Asn Pro           
                100                 105                 110               

gca cgc tac tgc tgc ctc agt ggc tgt acc caa caa gac ctg ctg acc        386
Ala Arg Tyr Cys Cys Leu Ser Gly Cys Thr Gln Gln Asp Leu Leu Thr           
            115                 120                 125                   

ctc tgt ccc tac tga ttcctccttg ggtgcagcct cagagtggcc tgaggcccag        441
Leu Cys Pro Tyr                                                           
        130                                                               

agggtctggt ctggtgagct cctgaggcca cacagcacca taaagtctcg catctacagg      501

cctttgatta cctcctggga tgggtgctca ctatctaccc cagaccaatg ccacctgcag      561

cctgtggagt caactgcaga ataaatcaca ccctagccct ggcttggagg atccccgctt      621

tcacagatgc tggacactga cagccaaatg tcctcactcc aggggagccc cagacgctcc      681

gctccctgca tgtgtaacac cccttcttgc tgtctcttag taaataaacg acccaaagca      741

gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      801

aaaaaaaaa                                                              810


<210>  124
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Asp Pro Arg Leu Pro Ala Trp Ala Leu Val Leu Leu Gly Pro Ala 
1               5                   10                  15      


Leu Val Phe Ala Leu Gly Pro Ala Pro Thr Pro Glu Met Arg Glu Lys 
            20                  25                  30          


Leu Cys Gly His His Phe Val Arg Ala Leu Val Arg Val Cys Gly Gly 
        35                  40                  45              


Pro Arg Trp Ser Thr Glu Ala Arg Arg Pro Ala Thr Gly Gly Asp Arg 
    50                  55                  60                  


Glu Leu Leu Gln Trp Leu Glu Arg Arg His Leu Leu His Gly Leu Val 
65                  70                  75                  80  


Ala Asp Ser Asn Leu Thr Leu Gly Pro Gly Leu Gln Pro Leu Pro Gln 
                85                  90                  95      


Thr Ser His His His Arg His His Arg Ala Ala Ala Thr Asn Pro Ala 
            100                 105                 110         


Arg Tyr Cys Cys Leu Ser Gly Cys Thr Gln Gln Asp Leu Leu Thr Leu 
        115                 120                 125             


Cys Pro Tyr 
    130     


<210>  125
<211>  1624
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (166)..(1128)

<400>  125
gttgcttgga tcagtctagg tgcagctgcc ggatccttca gcgtctgcat ctcggcgtcg       60

ccccgcgtac cgtcgcccgg ctctccgccg ctctcccggg gtttcggggc acttgggtcc      120

cacagtctgg tcctgcttca ccttcccctg acctgagtag tcgcc atg gca cag gtt      177
                                                  Met Ala Gln Val         
                                                  1                       

ctc aga ggc act gtg act gac ttc cct gga ttt gat gag cgg gct gat        225
Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp Glu Arg Ala Asp           
5                   10                  15                  20            

gca gaa act ctt cgg aag gct atg aaa ggc ttg ggc aca gat gag gag        273
Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Glu           
                25                  30                  35                

agc atc ctg act ctg ttg aca tcc cga agt aat gct cag cgc cag gaa        321
Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala Gln Arg Gln Glu           
            40                  45                  50                    

atc tct gca gct ttt aag act ctg ttt ggc agg gat ctt ctg gat gac        369
Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp Leu Leu Asp Asp           
        55                  60                  65                        

ctg aaa tca gaa cta act gga aaa ttt gaa aaa tta att gtg gct ctg        417
Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile Val Ala Leu           
    70                  75                  80                            

atg aaa ccc tct cgg ctt tat gat gct tat gaa ctg aaa cat gcc ttg        465
Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys His Ala Leu           
85                  90                  95                  100           

aag gga gct gga aca aat gaa aaa gta ctg aca gaa att att gct tca        513
Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu Ile Ile Ala Ser           
                105                 110                 115               

agg aca cct gaa gaa ctg aga gcc atc aaa caa gtt tat gaa gaa gaa        561
Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val Tyr Glu Glu Glu           
            120                 125                 130                   

tat ggc tca agc ctg gaa gat gac gtg gtg ggg gac act tca ggg tac        609
Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp Thr Ser Gly Tyr           
        135                 140                 145                       

tac cag cgg atg ttg gtg gtt ctc ctt cag gct aac aga gac cct gat        657
Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn Arg Asp Pro Asp           
    150                 155                 160                           

gct gga att gat gaa gct caa gtt gaa caa gat gct cag gct tta ttt        705
Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala Gln Ala Leu Phe           
165                 170                 175                 180           

cag gct gga gaa ctt aaa tgg ggg aca gat gaa gaa aag ttt atc acc        753
Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu Lys Phe Ile Thr           
                185                 190                 195               

atc ttt gga aca cga agt gtg tct cat ttg aga aag gtg ttt gac aag        801
Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys Val Phe Asp Lys           
            200                 205                 210                   

tac atg act ata tca gga ttt caa att gag gaa acc att gac cgc gag        849
Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr Ile Asp Arg Glu           
        215                 220                 225                       

act tct ggc aat tta gag caa cta ctc ctt gct gtt gtg aaa tct att        897
Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val Val Lys Ser Ile           
    230                 235                 240                           

cga agt ata cct gcc tac ctt gca gag acc ctc tat tat gct atg aag        945
Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr Tyr Ala Met Lys           
245                 250                 255                 260           

gga gct ggg aca gat gat cat acc ctc atc aga gtc atg gtt tcc agg        993
Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val Met Val Ser Arg           
                265                 270                 275               

agt gag att gat ctg ttt aac atc agg aag gag ttt agg aag aat ttt       1041
Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg Lys Asn Phe           
            280                 285                 290                   

gcc acc tct ctt tat tcc atg att aag gga gat aca tct ggg gac tat       1089
Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr Ser Gly Asp Tyr           
        295                 300                 305                       

aag aaa gct ctt ctg ctg ctc tgt gga gaa gat gac taa cgtgtcacgg        1138
Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp                           
    310                 315                 320                           

ggaagagctc cctgctgtgt gcctgcacca ccccactgcc ttccttcagc acctttagct     1198

gcatttgtat gccagtgctt aacacattgc cttattcata ctagcatgct catgaccaac     1258

acatacacgt catagaagaa aatagtggtg cttctttctg atctctagtg gagatctctt     1318

tgactgctgt agtactaaag tgtacttaat gttactaagt ttaatgcctg gccattttcc     1378

atttatatat attttttaag aggctagagt gcttttagcc ttttttaaaa actccattta     1438

tattacattt gtaaccatga tactttaatc agaagcttag ccttgaaatt gtgaactctt     1498

ggaaatgtta ttagtgaagt tcgcaactaa actaaacctg taaaattatg atgattgtat     1558

tcaaaagatt aatgaaaaat aaacatttct gtccccctga aaaaaaaaaa aaaaaaaaaa     1618

aaaaaa                                                                1624


<210>  126
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


<210>  127
<211>  2608
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (55)..(1656)

<400>  127
tccttcttca ttctgcagtt ggtgccagaa ctctggatcc tgaactggaa gaaa atg         57
                                                            Met           
                                                            1             

tct atc cag gtt gag cat cct gct ggt ggt tac aag aaa ctg ttt gaa        105
Ser Ile Gln Val Glu His Pro Ala Gly Gly Tyr Lys Lys Leu Phe Glu           
            5                   10                  15                    

act gtg gag gaa ctg tcc tcg ccg ctc aca gct cat gta aca ggc agg        153
Thr Val Glu Glu Leu Ser Ser Pro Leu Thr Ala His Val Thr Gly Arg           
        20                  25                  30                        

atc ccc ctc tgg ctc acc ggc agt ctc ctt cga tgt ggg cca gga ctc        201
Ile Pro Leu Trp Leu Thr Gly Ser Leu Leu Arg Cys Gly Pro Gly Leu           
    35                  40                  45                            

ttt gaa gtt gga tct gag cca ttt tac cac ctg ttt gat ggg caa gcc        249
Phe Glu Val Gly Ser Glu Pro Phe Tyr His Leu Phe Asp Gly Gln Ala           
50                  55                  60                  65            

ctc ctg cac aag ttt gac ttt aaa gaa gga cat gtc aca tac cac aga        297
Leu Leu His Lys Phe Asp Phe Lys Glu Gly His Val Thr Tyr His Arg           
                70                  75                  80                

agg ttc atc cgc act gat gct tac gta cgg gca atg act gag aaa agg        345
Arg Phe Ile Arg Thr Asp Ala Tyr Val Arg Ala Met Thr Glu Lys Arg           
            85                  90                  95                    

atc gtc ata aca gaa ttt ggc acc tgt gct ttc cca gat ccc tgc aag        393
Ile Val Ile Thr Glu Phe Gly Thr Cys Ala Phe Pro Asp Pro Cys Lys           
        100                 105                 110                       

aat ata ttt tcc agg ttt ttt tct tac ttt cga gga gta gag gtt act        441
Asn Ile Phe Ser Arg Phe Phe Ser Tyr Phe Arg Gly Val Glu Val Thr           
    115                 120                 125                           

gac aat gcc ctt gtt aat gtc tac cca gtg ggg gaa gat tac tac gct        489
Asp Asn Ala Leu Val Asn Val Tyr Pro Val Gly Glu Asp Tyr Tyr Ala           
130                 135                 140                 145           

tgc aca gag acc aac ttt att aca aag att aat cca gag acc ttg gag        537
Cys Thr Glu Thr Asn Phe Ile Thr Lys Ile Asn Pro Glu Thr Leu Glu           
                150                 155                 160               

aca att aag cag gtt gat ctt tgc aac tat gtc tct gtc aat ggg gcc        585
Thr Ile Lys Gln Val Asp Leu Cys Asn Tyr Val Ser Val Asn Gly Ala           
            165                 170                 175                   

act gct cac ccc cac att gaa aat gat gga acc gtt tac aat att ggt        633
Thr Ala His Pro His Ile Glu Asn Asp Gly Thr Val Tyr Asn Ile Gly           
        180                 185                 190                       

aat tgc ttt gga aaa aat ttt tca att gcc tac aac att gta aag atc        681
Asn Cys Phe Gly Lys Asn Phe Ser Ile Ala Tyr Asn Ile Val Lys Ile           
    195                 200                 205                           

cca cca ctg caa gca gac aag gaa gat cca ata agc aag tca gag atc        729
Pro Pro Leu Gln Ala Asp Lys Glu Asp Pro Ile Ser Lys Ser Glu Ile           
210                 215                 220                 225           

gtt gta caa ttc ccc tgc agt gac cga ttc aag cca tct tac gtt cat        777
Val Val Gln Phe Pro Cys Ser Asp Arg Phe Lys Pro Ser Tyr Val His           
                230                 235                 240               

agt ttt ggt ctg act ccc aac tat atc gtt ttt gtg gag aca cca gtc        825
Ser Phe Gly Leu Thr Pro Asn Tyr Ile Val Phe Val Glu Thr Pro Val           
            245                 250                 255                   

aaa att aac ctg ttc aag ttc ctt tct tca tgg agt ctt tgg gga gcc        873
Lys Ile Asn Leu Phe Lys Phe Leu Ser Ser Trp Ser Leu Trp Gly Ala           
        260                 265                 270                       

aac tac atg gat tgt ttt gag tcc aat gaa acc atg ggg gtt tgg ctt        921
Asn Tyr Met Asp Cys Phe Glu Ser Asn Glu Thr Met Gly Val Trp Leu           
    275                 280                 285                           

cat att gct gac aaa aaa agg aaa aag tac ctc aat aat aaa tac aga        969
His Ile Ala Asp Lys Lys Arg Lys Lys Tyr Leu Asn Asn Lys Tyr Arg           
290                 295                 300                 305           

act tct cct ttc aac ctc ttc cat cac atc aac acc tat gaa gac aat       1017
Thr Ser Pro Phe Asn Leu Phe His His Ile Asn Thr Tyr Glu Asp Asn           
                310                 315                 320               

ggg ttt ctg att gtg gat ctc tgc tgc tgg aaa gga ttt gag ttt gtt       1065
Gly Phe Leu Ile Val Asp Leu Cys Cys Trp Lys Gly Phe Glu Phe Val           
            325                 330                 335                   

tat aat tac tta tat tta gcc aat tta cgt gag aac tgg gaa gag gtg       1113
Tyr Asn Tyr Leu Tyr Leu Ala Asn Leu Arg Glu Asn Trp Glu Glu Val           
        340                 345                 350                       

aaa aaa aat gcc aga aag gct ccc caa cct gaa gtt agg aga tat gta       1161
Lys Lys Asn Ala Arg Lys Ala Pro Gln Pro Glu Val Arg Arg Tyr Val           
    355                 360                 365                           

ctt cct ttg aat att gac aag gct gac aca ggc aag aat tta gtc acg       1209
Leu Pro Leu Asn Ile Asp Lys Ala Asp Thr Gly Lys Asn Leu Val Thr           
370                 375                 380                 385           

ctc ccc aat aca act gcc act gca att ctg tgc agt gac gag act atc       1257
Leu Pro Asn Thr Thr Ala Thr Ala Ile Leu Cys Ser Asp Glu Thr Ile           
                390                 395                 400               

tgg ctg gag cct gaa gtt ctc ttt tca ggg cct cgt caa gca ttt gag       1305
Trp Leu Glu Pro Glu Val Leu Phe Ser Gly Pro Arg Gln Ala Phe Glu           
            405                 410                 415                   

ttt cct caa atc aat tac cag aag tat tgt ggg aaa cct tac aca tat       1353
Phe Pro Gln Ile Asn Tyr Gln Lys Tyr Cys Gly Lys Pro Tyr Thr Tyr           
        420                 425                 430                       

gcg tat gga ctt ggc ttg aat cac ttt gtt cca gat agg ctc tgt aag       1401
Ala Tyr Gly Leu Gly Leu Asn His Phe Val Pro Asp Arg Leu Cys Lys           
    435                 440                 445                           

ctg aat gtc aaa act aaa gaa act tgg gtt tgg caa gag cct gat tca       1449
Leu Asn Val Lys Thr Lys Glu Thr Trp Val Trp Gln Glu Pro Asp Ser           
450                 455                 460                 465           

tac cca tca gaa ccc atc ttt gtt tct cac cca gat gcc ttg gaa gaa       1497
Tyr Pro Ser Glu Pro Ile Phe Val Ser His Pro Asp Ala Leu Glu Glu           
                470                 475                 480               

gat gat ggt gta gtt ctg agt gtg gtg gtg agc cca gga gca gga caa       1545
Asp Asp Gly Val Val Leu Ser Val Val Val Ser Pro Gly Ala Gly Gln           
            485                 490                 495                   

aag cct gct tat ctc ctg att ctg aat gcc aag gac tta agt gaa gtt       1593
Lys Pro Ala Tyr Leu Leu Ile Leu Asn Ala Lys Asp Leu Ser Glu Val           
        500                 505                 510                       

gcc cgg gct gaa gtg gag att aac atc cct gtc acc ttt cat gga ctg       1641
Ala Arg Ala Glu Val Glu Ile Asn Ile Pro Val Thr Phe His Gly Leu           
    515                 520                 525                           

ttc aaa aaa tct tga gcatactcca gcaagatatg tttttggtag caaaactgag       1696
Phe Lys Lys Ser                                                           
530                                                                       

aaaatcagct tcaggtctgc aatcaaattc tgttcaattt tagcctgcta tatgtcatgg     1756

ttttaacttg cagatgcgca caattttgca atgttttaca gaaagcactg agttgagcaa     1816

gcaattcctt tatttaaaaa aaaaagtacg tatttagata atcatacttc ctctgtgaga     1876

caggccataa ctgaaaaact cttaaatatt tagcaatcaa ataggaaatg aatgtggact     1936

tactaaatgg cttttaattc ctattataag agcatatttt aggtacctat ctgctccaat     1996

tatattttta acatttaaaa accaaagtcc tctacacttg atttatatta tatgtggctt     2056

tgctgagtca aggaagtatc atgcaataag gcttaattac taaatgtcaa accaaacttt     2116

ttctcaaacc agggactatc atctaagatt aattacagta attattttgc gtatacgtaa     2176

ctgctcaaag attatgaatc ttatgaatgt taacctttcc gtttattaca agcaagtact     2236

attatttctg attttataat aagaaaatct gtgtttaatc aactgaggcc tctcaaccaa     2296

ataacatctc agagattaag ttatatatta aaagcttatg taacataaaa gcaagtacat     2356

atagtagtga ctatatttaa aaaaacagca taaaatgctt aaaaatgtaa tatttactaa     2416

aatcagatta tgggataatg ttgcaggatt atactttatt gcatcttttt tgtttaattg     2476

tatttaagca ttgtgcaatc acttgggaaa aatattaaat tattaacatt gaggtattaa     2536

tacattttaa gccttttgtt tttaaatttc ttttcttcca gagattgttt aaaaataaat     2596

attgacaaaa at                                                         2608


<210>  128
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Ser Ile Gln Val Glu His Pro Ala Gly Gly Tyr Lys Lys Leu Phe 
1               5                   10                  15      


Glu Thr Val Glu Glu Leu Ser Ser Pro Leu Thr Ala His Val Thr Gly 
            20                  25                  30          


Arg Ile Pro Leu Trp Leu Thr Gly Ser Leu Leu Arg Cys Gly Pro Gly 
        35                  40                  45              


Leu Phe Glu Val Gly Ser Glu Pro Phe Tyr His Leu Phe Asp Gly Gln 
    50                  55                  60                  


Ala Leu Leu His Lys Phe Asp Phe Lys Glu Gly His Val Thr Tyr His 
65                  70                  75                  80  


Arg Arg Phe Ile Arg Thr Asp Ala Tyr Val Arg Ala Met Thr Glu Lys 
                85                  90                  95      


Arg Ile Val Ile Thr Glu Phe Gly Thr Cys Ala Phe Pro Asp Pro Cys 
            100                 105                 110         


Lys Asn Ile Phe Ser Arg Phe Phe Ser Tyr Phe Arg Gly Val Glu Val 
        115                 120                 125             


Thr Asp Asn Ala Leu Val Asn Val Tyr Pro Val Gly Glu Asp Tyr Tyr 
    130                 135                 140                 


Ala Cys Thr Glu Thr Asn Phe Ile Thr Lys Ile Asn Pro Glu Thr Leu 
145                 150                 155                 160 


Glu Thr Ile Lys Gln Val Asp Leu Cys Asn Tyr Val Ser Val Asn Gly 
                165                 170                 175     


Ala Thr Ala His Pro His Ile Glu Asn Asp Gly Thr Val Tyr Asn Ile 
            180                 185                 190         


Gly Asn Cys Phe Gly Lys Asn Phe Ser Ile Ala Tyr Asn Ile Val Lys 
        195                 200                 205             


Ile Pro Pro Leu Gln Ala Asp Lys Glu Asp Pro Ile Ser Lys Ser Glu 
    210                 215                 220                 


Ile Val Val Gln Phe Pro Cys Ser Asp Arg Phe Lys Pro Ser Tyr Val 
225                 230                 235                 240 


His Ser Phe Gly Leu Thr Pro Asn Tyr Ile Val Phe Val Glu Thr Pro 
                245                 250                 255     


Val Lys Ile Asn Leu Phe Lys Phe Leu Ser Ser Trp Ser Leu Trp Gly 
            260                 265                 270         


Ala Asn Tyr Met Asp Cys Phe Glu Ser Asn Glu Thr Met Gly Val Trp 
        275                 280                 285             


Leu His Ile Ala Asp Lys Lys Arg Lys Lys Tyr Leu Asn Asn Lys Tyr 
    290                 295                 300                 


Arg Thr Ser Pro Phe Asn Leu Phe His His Ile Asn Thr Tyr Glu Asp 
305                 310                 315                 320 


Asn Gly Phe Leu Ile Val Asp Leu Cys Cys Trp Lys Gly Phe Glu Phe 
                325                 330                 335     


Val Tyr Asn Tyr Leu Tyr Leu Ala Asn Leu Arg Glu Asn Trp Glu Glu 
            340                 345                 350         


Val Lys Lys Asn Ala Arg Lys Ala Pro Gln Pro Glu Val Arg Arg Tyr 
        355                 360                 365             


Val Leu Pro Leu Asn Ile Asp Lys Ala Asp Thr Gly Lys Asn Leu Val 
    370                 375                 380                 


Thr Leu Pro Asn Thr Thr Ala Thr Ala Ile Leu Cys Ser Asp Glu Thr 
385                 390                 395                 400 


Ile Trp Leu Glu Pro Glu Val Leu Phe Ser Gly Pro Arg Gln Ala Phe 
                405                 410                 415     


Glu Phe Pro Gln Ile Asn Tyr Gln Lys Tyr Cys Gly Lys Pro Tyr Thr 
            420                 425                 430         


Tyr Ala Tyr Gly Leu Gly Leu Asn His Phe Val Pro Asp Arg Leu Cys 
        435                 440                 445             


Lys Leu Asn Val Lys Thr Lys Glu Thr Trp Val Trp Gln Glu Pro Asp 
    450                 455                 460                 


Ser Tyr Pro Ser Glu Pro Ile Phe Val Ser His Pro Asp Ala Leu Glu 
465                 470                 475                 480 


Glu Asp Asp Gly Val Val Leu Ser Val Val Val Ser Pro Gly Ala Gly 
                485                 490                 495     


Gln Lys Pro Ala Tyr Leu Leu Ile Leu Asn Ala Lys Asp Leu Ser Glu 
            500                 505                 510         


Val Ala Arg Ala Glu Val Glu Ile Asn Ile Pro Val Thr Phe His Gly 
        515                 520                 525             


Leu Phe Lys Lys Ser 
    530             


<210>  129
<211>  5988
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (517)..(4173)

<400>  129
ctgcccggcg tgctgggtag aggtggccag ccccggccgc tgctgccaga cgggctctcc       60

gggtccttct ccgagagccg ggcgggcacg cgtcattgtg ttacctgcgg ccggcccgcg      120

agctaggctg gttttttttt ttctcccctc cctcccccct ttttccatgc agctgatcta      180

aaagggaata aaaggctgcg cataatcata ataataaaag aaggggagcg cgagagaagg      240

aaagaaagcc gggaggtgga agaggagggg gagcgtctca aagaagcgat cagaataata      300

aaaggaggcc gggctctttg ccttctggaa cgggccgctc ttgaaagggc ttttgaaaag      360

tggtgttgtt ttccagtcgt gcatgctcca atcggcggag tatattagag ccgggacgcg      420

gcggccgcag gggcagcggc gacggcagca ccggcggcag caccagcgcg aacagcagcg      480

gcggcgtccc gagtgcccgc ggcgcgcggc gcagcg atg cgt tcc cca cgg acg        534
                                        Met Arg Ser Pro Arg Thr           
                                        1               5                 

cgc ggc cgg tcc ggg cgc ccc cta agc ctc ctg ctc gcc ctg ctc tgt        582
Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu Leu Leu Ala Leu Leu Cys           
            10                  15                  20                    

gcc ctg cga gcc aag gtg tgt ggg gcc tcg ggt cag ttc gag ttg gag        630
Ala Leu Arg Ala Lys Val Cys Gly Ala Ser Gly Gln Phe Glu Leu Glu           
        25                  30                  35                        

atc ctg tcc atg cag aac gtg aac ggg gag ctg cag aac ggg aac tgc        678
Ile Leu Ser Met Gln Asn Val Asn Gly Glu Leu Gln Asn Gly Asn Cys           
    40                  45                  50                            

tgc ggc ggc gcc cgg aac ccg gga gac cgc aag tgc acc cgc gac gag        726
Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg Lys Cys Thr Arg Asp Glu           
55                  60                  65                  70            

tgt gac aca tac ttc aaa gtg tgc ctc aag gag tat cag tcc cgc gtc        774
Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys Glu Tyr Gln Ser Arg Val           
                75                  80                  85                

acg gcc ggg ggg ccc tgc agc ttc ggc tca ggg tcc acg cct gtc atc        822
Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser Gly Ser Thr Pro Val Ile           
            90                  95                  100                   

ggg ggc aac acc ttc aac ctc aag gcc agc cgc ggc aac gac cgc aac        870
Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser Arg Gly Asn Asp Arg Asn           
        105                 110                 115                       

cgc atc gtg ctg cct ttc agt ttc gcc tgg ccg agg tcc tat acg ttg        918
Arg Ile Val Leu Pro Phe Ser Phe Ala Trp Pro Arg Ser Tyr Thr Leu           
    120                 125                 130                           

ctt gtg gag gcg tgg gat tcc agt aat gac acc gtt caa cct gac agt        966
Leu Val Glu Ala Trp Asp Ser Ser Asn Asp Thr Val Gln Pro Asp Ser           
135                 140                 145                 150           

att att gaa aag gct tct cac tcg ggc atg atc aac ccc agc cgg cag       1014
Ile Ile Glu Lys Ala Ser His Ser Gly Met Ile Asn Pro Ser Arg Gln           
                155                 160                 165               

tgg cag acg ctg aag cag aac acg ggc gtt gcc cac ttt gag tat cag       1062
Trp Gln Thr Leu Lys Gln Asn Thr Gly Val Ala His Phe Glu Tyr Gln           
            170                 175                 180                   

atc cgc gtg acc tgt gat gac tac tac tat ggc ttt ggc tgc aat aag       1110
Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr Gly Phe Gly Cys Asn Lys           
        185                 190                 195                       

ttc tgc cgc ccc aga gat gac ttc ttt gga cac tat gcc tgt gac cag       1158
Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly His Tyr Ala Cys Asp Gln           
    200                 205                 210                           

aat ggc aac aaa act tgc atg gaa ggc tgg atg ggc ccc gaa tgt aac       1206
Asn Gly Asn Lys Thr Cys Met Glu Gly Trp Met Gly Pro Glu Cys Asn           
215                 220                 225                 230           

aga gct att tgc cga caa ggc tgc agt cct aag cat ggg tct tgc aaa       1254
Arg Ala Ile Cys Arg Gln Gly Cys Ser Pro Lys His Gly Ser Cys Lys           
                235                 240                 245               

ctc cca ggt gac tgc agg tgc cag tac ggc tgg caa ggc ctg tac tgt       1302
Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly Trp Gln Gly Leu Tyr Cys           
            250                 255                 260                   

gat aag tgc atc cca cac ccg gga tgc gtc cac ggc atc tgt aat gag       1350
Asp Lys Cys Ile Pro His Pro Gly Cys Val His Gly Ile Cys Asn Glu           
        265                 270                 275                       

ccc tgg cag tgc ctc tgt gag acc aac tgg ggc ggc cag ctc tgt gac       1398
Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp Gly Gly Gln Leu Cys Asp           
    280                 285                 290                           

aaa gat ctc aat tac tgt ggg act cat cag ccg tgt ctc aac ggg gga       1446
Lys Asp Leu Asn Tyr Cys Gly Thr His Gln Pro Cys Leu Asn Gly Gly           
295                 300                 305                 310           

act tgt agc aac aca ggc cct gac aaa tat cag tgt tcc tgc cct gag       1494
Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr Gln Cys Ser Cys Pro Glu           
                315                 320                 325               

ggg tat tca gga ccc aac tgt gaa att gct gag cac gcc tgc ctc tct       1542
Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala Glu His Ala Cys Leu Ser           
            330                 335                 340                   

gat ccc tgt cac aac aga ggc agc tgt aag gag acc tcc ctg ggc ttt       1590
Asp Pro Cys His Asn Arg Gly Ser Cys Lys Glu Thr Ser Leu Gly Phe           
        345                 350                 355                       

gag tgt gag tgt tcc cca ggc tgg acc ggc ccc aca tgc tct aca aac       1638
Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly Pro Thr Cys Ser Thr Asn           
    360                 365                 370                           

att gat gac tgt tct cct aat aac tgt tcc cac ggg ggc acc tgc cag       1686
Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser His Gly Gly Thr Cys Gln           
375                 380                 385                 390           

gac ctg gtt aac gga ttt aag tgt gtg tgc ccc cca cag tgg act ggg       1734
Asp Leu Val Asn Gly Phe Lys Cys Val Cys Pro Pro Gln Trp Thr Gly           
                395                 400                 405               

aaa acg tgc cag tta gat gca aat gaa tgt gag gcc aaa cct tgt gta       1782
Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys Glu Ala Lys Pro Cys Val           
            410                 415                 420                   

aac gcc aaa tcc tgt aag aat ctc att gcc agc tac tac tgc gac tgt       1830
Asn Ala Lys Ser Cys Lys Asn Leu Ile Ala Ser Tyr Tyr Cys Asp Cys           
        425                 430                 435                       

ctt ccc ggc tgg atg ggt cag aat tgt gac ata aat att aat gac tgc       1878
Leu Pro Gly Trp Met Gly Gln Asn Cys Asp Ile Asn Ile Asn Asp Cys           
    440                 445                 450                           

ctt ggc cag tgt cag aat gac gcc tcc tgt cgg gat ttg gtt aat ggt       1926
Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys Arg Asp Leu Val Asn Gly           
455                 460                 465                 470           

tat cgc tgt atc tgt cca cct ggc tat gca ggc gat cac tgt gag aga       1974
Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala Gly Asp His Cys Glu Arg           
                475                 480                 485               

gac atc gat gaa tgt gcc agc aac ccc tgt ttg aat ggg ggt cac tgt       2022
Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys Leu Asn Gly Gly His Cys           
            490                 495                 500                   

cag aat gaa atc aac aga ttc cag tgt ctg tgt ccc act ggt ttc tct       2070
Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu Cys Pro Thr Gly Phe Ser           
        505                 510                 515                       

gga aac ctc tgt cag ctg gac atc gat tat tgt gag cct aat ccc tgc       2118
Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr Cys Glu Pro Asn Pro Cys           
    520                 525                 530                           

cag aac ggt gcc cag tgc tac aac cgt gcc agt gac tat ttc tgc aag       2166
Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala Ser Asp Tyr Phe Cys Lys           
535                 540                 545                 550           

tgc ccc gag gac tat gag ggc aag aac tgc tca cac ctg aaa gac cac       2214
Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys Ser His Leu Lys Asp His           
                555                 560                 565               

tgc cgc acg acc ccc tgt gaa gtg att gac agc tgc aca gtg gcc atg       2262
Cys Arg Thr Thr Pro Cys Glu Val Ile Asp Ser Cys Thr Val Ala Met           
            570                 575                 580                   

gct tcc aac gac aca cct gaa ggg gtg cgg tat att tcc tcc aac gtc       2310
Ala Ser Asn Asp Thr Pro Glu Gly Val Arg Tyr Ile Ser Ser Asn Val           
        585                 590                 595                       

tgt ggt cct cac ggg aag tgc aag agt cag tcg gga ggc aaa ttc acc       2358
Cys Gly Pro His Gly Lys Cys Lys Ser Gln Ser Gly Gly Lys Phe Thr           
    600                 605                 610                           

tgt gac tgt aac aaa ggc ttc acg gga aca tac tgc cat gaa aat att       2406
Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr Tyr Cys His Glu Asn Ile           
615                 620                 625                 630           

aat gac tgt gag agc aac cct tgt aga aac ggt ggc act tgc atc gat       2454
Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn Gly Gly Thr Cys Ile Asp           
                635                 640                 645               

ggt gtc aac tcc tac aag tgc atc tgt agt gac ggc tgg gag ggg gcc       2502
Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser Asp Gly Trp Glu Gly Ala           
            650                 655                 660                   

tac tgt gaa acc aat att aat gac tgc agc cag aac ccc tgc cac aat       2550
Tyr Cys Glu Thr Asn Ile Asn Asp Cys Ser Gln Asn Pro Cys His Asn           
        665                 670                 675                       

ggg ggc acg tgt cgc gac ctg gtc aat gac ttc tac tgt gac tgt aaa       2598
Gly Gly Thr Cys Arg Asp Leu Val Asn Asp Phe Tyr Cys Asp Cys Lys           
    680                 685                 690                           

aat ggg tgg aaa gga aag acc tgc cac tca cgt gac agt cag tgt gat       2646
Asn Gly Trp Lys Gly Lys Thr Cys His Ser Arg Asp Ser Gln Cys Asp           
695                 700                 705                 710           

gag gcc acg tgc aac aac ggt ggc acc tgc tat gat gag ggg gat gct       2694
Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys Tyr Asp Glu Gly Asp Ala           
                715                 720                 725               

ttt aag tgc atg tgt cct ggc ggc tgg gaa gga aca acc tgt aac ata       2742
Phe Lys Cys Met Cys Pro Gly Gly Trp Glu Gly Thr Thr Cys Asn Ile           
            730                 735                 740                   

gcc cga aac agt agc tgc ctg ccc aac ccc tgc cat aat ggg ggc aca       2790
Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro Cys His Asn Gly Gly Thr           
        745                 750                 755                       

tgt gtg gtc aac ggc gag tcc ttt acg tgc gtc tgc aag gaa ggc tgg       2838
Cys Val Val Asn Gly Glu Ser Phe Thr Cys Val Cys Lys Glu Gly Trp           
    760                 765                 770                           

gag ggg ccc atc tgt gct cag aat acc aat gac tgc agc cct cat ccc       2886
Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn Asp Cys Ser Pro His Pro           
775                 780                 785                 790           

tgt tac aac agc ggc acc tgt gtg gat gga gac aac tgg tac cgg tgc       2934
Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly Asp Asn Trp Tyr Arg Cys           
                795                 800                 805               

gaa tgt gcc ccg ggt ttt gct ggg ccc gac tgc aga ata aac atc aat       2982
Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp Cys Arg Ile Asn Ile Asn           
            810                 815                 820                   

gaa tgc cag tct tca cct tgt gcc ttt gga gcg acc tgt gtg gat gag       3030
Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly Ala Thr Cys Val Asp Glu           
        825                 830                 835                       

atc aat ggc tac cgg tgt gtc tgc cct cca ggg cac agt ggt gcc aag       3078
Ile Asn Gly Tyr Arg Cys Val Cys Pro Pro Gly His Ser Gly Ala Lys           
    840                 845                 850                           

tgc cag gaa gtt tca ggg aga cct tgc atc acc atg ggg agt gtg ata       3126
Cys Gln Glu Val Ser Gly Arg Pro Cys Ile Thr Met Gly Ser Val Ile           
855                 860                 865                 870           

cca gat ggg gcc aaa tgg gat gat gac tgt aat acc tgc cag tgc ctg       3174
Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys Asn Thr Cys Gln Cys Leu           
                875                 880                 885               

aat gga cgg atc gcc tgc tca aag gtc tgg tgt ggc cct cga cct tgc       3222
Asn Gly Arg Ile Ala Cys Ser Lys Val Trp Cys Gly Pro Arg Pro Cys           
            890                 895                 900                   

ctg ctc cac aaa ggg cac agc gag tgc ccc agc ggg cag agc tgc atc       3270
Leu Leu His Lys Gly His Ser Glu Cys Pro Ser Gly Gln Ser Cys Ile           
        905                 910                 915                       

ccc atc ctg gac gac cag tgc ttc gtc cac ccc tgc act ggt gtg ggc       3318
Pro Ile Leu Asp Asp Gln Cys Phe Val His Pro Cys Thr Gly Val Gly           
    920                 925                 930                           

gag tgt cgg tct tcc agt ctc cag ccg gtg aag aca aag tgc acc tct       3366
Glu Cys Arg Ser Ser Ser Leu Gln Pro Val Lys Thr Lys Cys Thr Ser           
935                 940                 945                 950           

gac tcc tat tac cag gat aac tgt gcg aac atc aca ttt acc ttt aac       3414
Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn Ile Thr Phe Thr Phe Asn           
                955                 960                 965               

aag gag atg atg tca cca ggt ctt act acg gag cac att tgc agt gaa       3462
Lys Glu Met Met Ser Pro Gly Leu Thr Thr Glu His Ile Cys Ser Glu           
            970                 975                 980                   

ttg agg aat ttg aat att ttg aag aat gtt tcc gct gaa tat tca atc       3510
Leu Arg Asn Leu Asn Ile Leu Lys Asn Val Ser Ala Glu Tyr Ser Ile           
        985                 990                 995                       

tac atc  gct tgc gag cct tcc  cct tca gcg aac aat  gaa ata cat        3555
Tyr Ile  Ala Cys Glu Pro Ser  Pro Ser Ala Asn Asn  Glu Ile His            
    1000                 1005                 1010                        

gtg gcc  att tct gct gaa gat  ata cgg gat gat ggg  aac ccg atc        3600
Val Ala  Ile Ser Ala Glu Asp  Ile Arg Asp Asp Gly  Asn Pro Ile            
    1015                 1020                 1025                        

aag gaa  atc act gac aaa ata  atc gat ctt gtt agt  aaa cgt gat        3645
Lys Glu  Ile Thr Asp Lys Ile  Ile Asp Leu Val Ser  Lys Arg Asp            
    1030                 1035                 1040                        

gga aac  agc tcg ctg att gct  gcc gtt gca gaa gta  aga gtt cag        3690
Gly Asn  Ser Ser Leu Ile Ala  Ala Val Ala Glu Val  Arg Val Gln            
    1045                 1050                 1055                        

agg cgg  cct ctg aag aac aga  aca gat ttc ctt gtt  ccc ttg ctg        3735
Arg Arg  Pro Leu Lys Asn Arg  Thr Asp Phe Leu Val  Pro Leu Leu            
    1060                 1065                 1070                        

agc tct  gtc tta act gtg gct  tgg atc tgt tgc ttg  gtg acg gcc        3780
Ser Ser  Val Leu Thr Val Ala  Trp Ile Cys Cys Leu  Val Thr Ala            
    1075                 1080                 1085                        

ttc tac  tgg tgc ctg cgg aag  cgg cgg aag ccg ggc  agc cac aca        3825
Phe Tyr  Trp Cys Leu Arg Lys  Arg Arg Lys Pro Gly  Ser His Thr            
    1090                 1095                 1100                        

cac tca  gcc tct gag gac aac  acc acc aac aac gtg  cgg gag cag        3870
His Ser  Ala Ser Glu Asp Asn  Thr Thr Asn Asn Val  Arg Glu Gln            
    1105                 1110                 1115                        

ctg aac  cag atc aaa aac ccc  att gag aaa cat ggg  gcc aac acg        3915
Leu Asn  Gln Ile Lys Asn Pro  Ile Glu Lys His Gly  Ala Asn Thr            
    1120                 1125                 1130                        

gtc ccc  atc aag gat tat gag  aac aag aac tcc aaa  atg tct aaa        3960
Val Pro  Ile Lys Asp Tyr Glu  Asn Lys Asn Ser Lys  Met Ser Lys            
    1135                 1140                 1145                        

ata agg  aca cac aat tct gaa  gta gaa gag gac gac  atg gac aaa        4005
Ile Arg  Thr His Asn Ser Glu  Val Glu Glu Asp Asp  Met Asp Lys            
    1150                 1155                 1160                        

cac cag  cag aaa gcc cgg ttt  gcc aag cag ccg gcg  tac acg ctg        4050
His Gln  Gln Lys Ala Arg Phe  Ala Lys Gln Pro Ala  Tyr Thr Leu            
    1165                 1170                 1175                        

gta gac  aga gaa gag aag ccc  ccc aac ggc acg ccg  aca aaa cac        4095
Val Asp  Arg Glu Glu Lys Pro  Pro Asn Gly Thr Pro  Thr Lys His            
    1180                 1185                 1190                        

cca aac  tgg aca aac aaa cag  gac aac aga gac ttg  gaa agt gcc        4140
Pro Asn  Trp Thr Asn Lys Gln  Asp Asn Arg Asp Leu  Glu Ser Ala            
    1195                 1200                 1205                        

cag agc  tta aac cga atg gag  tac atc gta tag cagaccgcgg              4183
Gln Ser  Leu Asn Arg Met Glu  Tyr Ile Val                                 
    1210                 1215                                             

gcactgccgc cgctaggtag agtctgaggg cttgtagttc tttaaactgt cgtgtcatac     4243

tcgagtctga ggccgttgct gacttagaat ccctgtgtta atttaagttt tgacaagctg     4303

gcttacactg gcaatggtag tttctgtggt tggctgggaa atcgagtgcc gcatctcaca     4363

gctatgcaaa aagctagtca acagtaccct ggttgtgtgt ccccttgcag ccgacacggt     4423

ctcggatcag gctcccagga gcctgcccag ccccctggtc tttgagctcc cacttctgcc     4483

agatgtccta atggtgatgc agtcttagat catagtttta tttatattta ttgactcttg     4543

agttgttttt gtatattggt tttatgatga cgtacaagta gttctgtatt tgaaagtgcc     4603

tttgcagctc agaaccacag caacgatcac aaatgacttt attatttatt ttttttaatt     4663

gtatttttgt tgttggggga ggggagactt tgatgtcagc agttgctggt aaaatgaaga     4723

atttaaagaa aaaaatgtca aaagtagaac tttgtatagt tatgtaaata attctttttt     4783

attaatcact gtgtatattt gatttattaa cttaataatc aagagcctta aaacatcatt     4843

cctttttatt tatatgtatg tgtttagaat tgaaggtttt tgatagcatt gtaagcgtat     4903

ggctttattt ttttgaactc ttctcattac ttgttgccta taagccaaaa ttaaggtgtt     4963

tgaaaatagt ttattttaaa acaataggat gggcttctgt gcccagaata ctgatggaat     5023

ttttttgtac gacgtcagat gtttaaaaca ccttctatag catcacttaa aacacgtttt     5083

aaggactgac tgaggcagtt tgaggattag tttagaacag gtttttttgt ttgtttgttt     5143

tttgtttttc tgctttagac ttgaaaagag acaggcaggt gatctgctgc agagcagtaa     5203

gggaacaagt tgagctatga cttaacatag ccaaaatgtg agtggttgaa tatgattaaa     5263

aatatcaaat taattgtgtg aacttggaag cacaccaatc ttactttgta aattctgatt     5323

tcttttcacc attcgtacat aatactgaac cacttgtaga tttgattttt ttttttaatc     5383

tactgcattt agggagtatt ctaataagct agttgaatac ttgaaccata aaatgtccag     5443

taagatcact gtttagattt gccatagagt acactgcctg ccttaagtga ggaaatcaaa     5503

gtgctattac gaagttcaag atcaaaaagg cttataaaac agagtaatct tgttggttca     5563

ccattgagac cgtgaagata ctttgtattg tcctattagt gttatatgaa catacaaatg     5623

catctttgat gtgttgttct tggcaataaa ttttgaaaag taatatttat taaatttttt     5683

tgtatgaaaa catggaacag tgtggcctct tctgagctta cgtagttcta ccggctttgc     5743

catgtgcttc tgccaccctg ctgagtctgt tctggtaatc ggggtataat aggctctgcc     5803

tgacagaggg atggaggaag aactgaaagg cttttcaacc acaaaactca tctggagttc     5863

tcaaagacct ggggctgctg tgaagctgga actgcgggag ccccatctag gggagccttg     5923

attcccttgt tattcaacag caagtgtgaa tactgcttga ataaacacca ctggattaat     5983

ggcca                                                                 5988


<210>  130
<211>  1218
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Arg Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu 
1               5                   10                  15      


Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
            20                  25                  30          


Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
        35                  40                  45              


Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
    50                  55                  60                  


Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
65                  70                  75                  80  


Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                85                  90                  95      


Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
            100                 105                 110         


Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
        115                 120                 125             


Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
    130                 135                 140                 


Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
145                 150                 155                 160 


Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Val 
                165                 170                 175     


Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr 
            180                 185                 190         


Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly 
        195                 200                 205             


His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp 
    210                 215                 220                 


Met Gly Pro Glu Cys Asn Arg Ala Ile Cys Arg Gln Gly Cys Ser Pro 
225                 230                 235                 240 


Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 
                245                 250                 255     


Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 
            260                 265                 270         


His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 
        275                 280                 285             


Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln 
    290                 295                 300                 


Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr 
305                 310                 315                 320 


Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala 
                325                 330                 335     


Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys 
            340                 345                 350         


Glu Thr Ser Leu Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 
        355                 360                 365             


Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 
    370                 375                 380                 


His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 
385                 390                 395                 400 


Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys 
                405                 410                 415     


Glu Ala Lys Pro Cys Val Asn Ala Lys Ser Cys Lys Asn Leu Ile Ala 
            420                 425                 430         


Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp 
        435                 440                 445             


Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys 
    450                 455                 460                 


Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala 
465                 470                 475                 480 


Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 
                485                 490                 495     


Leu Asn Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 
            500                 505                 510         


Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 
        515                 520                 525             


Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala 
    530                 535                 540                 


Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys 
545                 550                 555                 560 


Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp 
                565                 570                 575     


Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg 
            580                 585                 590         


Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Gln 
        595                 600                 605             


Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 
    610                 615                 620                 


Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn 
625                 630                 635                 640 


Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 
                645                 650                 655     


Asp Gly Trp Glu Gly Ala Tyr Cys Glu Thr Asn Ile Asn Asp Cys Ser 
            660                 665                 670         


Gln Asn Pro Cys His Asn Gly Gly Thr Cys Arg Asp Leu Val Asn Asp 
        675                 680                 685             


Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser 
    690                 695                 700                 


Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys 
705                 710                 715                 720 


Tyr Asp Glu Gly Asp Ala Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 
                725                 730                 735     


Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 
            740                 745                 750         


Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Glu Ser Phe Thr Cys 
        755                 760                 765             


Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn 
    770                 775                 780                 


Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly 
785                 790                 795                 800 


Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp 
                805                 810                 815     


Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly 
            820                 825                 830         


Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Arg Cys Val Cys Pro Pro 
        835                 840                 845             


Gly His Ser Gly Ala Lys Cys Gln Glu Val Ser Gly Arg Pro Cys Ile 
    850                 855                 860                 


Thr Met Gly Ser Val Ile Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys 
865                 870                 875                 880 


Asn Thr Cys Gln Cys Leu Asn Gly Arg Ile Ala Cys Ser Lys Val Trp 
                885                 890                 895     


Cys Gly Pro Arg Pro Cys Leu Leu His Lys Gly His Ser Glu Cys Pro 
            900                 905                 910         


Ser Gly Gln Ser Cys Ile Pro Ile Leu Asp Asp Gln Cys Phe Val His 
        915                 920                 925             


Pro Cys Thr Gly Val Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val 
    930                 935                 940                 


Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn 
945                 950                 955                 960 


Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr 
                965                 970                 975     


Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 
            980                 985                 990         


Ser Ala Glu Tyr Ser Ile Tyr Ile  Ala Cys Glu Pro Ser  Pro Ser Ala 
        995                 1000                 1005             


Asn Asn  Glu Ile His Val Ala  Ile Ser Ala Glu Asp  Ile Arg Asp 
    1010                 1015                 1020             


Asp Gly  Asn Pro Ile Lys Glu  Ile Thr Asp Lys Ile  Ile Asp Leu 
    1025                 1030                 1035             


Val Ser  Lys Arg Asp Gly Asn  Ser Ser Leu Ile Ala  Ala Val Ala 
    1040                 1045                 1050             


Glu Val  Arg Val Gln Arg Arg  Pro Leu Lys Asn Arg  Thr Asp Phe 
    1055                 1060                 1065             


Leu Val  Pro Leu Leu Ser Ser  Val Leu Thr Val Ala  Trp Ile Cys 
    1070                 1075                 1080             


Cys Leu  Val Thr Ala Phe Tyr  Trp Cys Leu Arg Lys  Arg Arg Lys 
    1085                 1090                 1095             


Pro Gly  Ser His Thr His Ser  Ala Ser Glu Asp Asn  Thr Thr Asn 
    1100                 1105                 1110             


Asn Val  Arg Glu Gln Leu Asn  Gln Ile Lys Asn Pro  Ile Glu Lys 
    1115                 1120                 1125             


His Gly  Ala Asn Thr Val Pro  Ile Lys Asp Tyr Glu  Asn Lys Asn 
    1130                 1135                 1140             


Ser Lys  Met Ser Lys Ile Arg  Thr His Asn Ser Glu  Val Glu Glu 
    1145                 1150                 1155             


Asp Asp  Met Asp Lys His Gln  Gln Lys Ala Arg Phe  Ala Lys Gln 
    1160                 1165                 1170             


Pro Ala  Tyr Thr Leu Val Asp  Arg Glu Glu Lys Pro  Pro Asn Gly 
    1175                 1180                 1185             


Thr Pro  Thr Lys His Pro Asn  Trp Thr Asn Lys Gln  Asp Asn Arg 
    1190                 1195                 1200             


Asp Leu  Glu Ser Ala Gln Ser  Leu Asn Arg Met Glu  Tyr Ile Val 
    1205                 1210                 1215             


<210>  131
<211>  2136
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (100)..(2040)

<400>  131
gtgtgtggag gggaccctgt ggttagcagc agctatcgca gcgtcggatg ttcagagcag       60

cagaagccgg cgtcgtcgga tgttgtgttg cccgccacc atg agc tac aca ggc         114
                                           Met Ser Tyr Thr Gly            
                                           1               5              

ttt gtc cag gga tct gaa acc act ttg cag tcg aca tac tcg gat acc        162
Phe Val Gln Gly Ser Glu Thr Thr Leu Gln Ser Thr Tyr Ser Asp Thr           
                10                  15                  20                

agc gct cag ccc acc tgt gat tat gga tat gga act tgg aac tct ggg        210
Ser Ala Gln Pro Thr Cys Asp Tyr Gly Tyr Gly Thr Trp Asn Ser Gly           
            25                  30                  35                    

aca aat aga ggc tac gag ggc tat ggc tat ggc tat ggc tat ggc cag        258
Thr Asn Arg Gly Tyr Glu Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Gln           
        40                  45                  50                        

gat aac acc acc aac tat ggg tat ggt atg gcc act tca cac tct tgg        306
Asp Asn Thr Thr Asn Tyr Gly Tyr Gly Met Ala Thr Ser His Ser Trp           
    55                  60                  65                            

gaa atg cct agc tct gac aca aat gca aac act agt gcc tcg ggt agc        354
Glu Met Pro Ser Ser Asp Thr Asn Ala Asn Thr Ser Ala Ser Gly Ser           
70                  75                  80                  85            

gcc agt gcc gat tcc gtt tta tcc aga att aac cag cgc tta gat atg        402
Ala Ser Ala Asp Ser Val Leu Ser Arg Ile Asn Gln Arg Leu Asp Met           
                90                  95                  100               

gtg ccg cat ttg gag aca gac atg atg caa gga ggc gtg tac ggc tca        450
Val Pro His Leu Glu Thr Asp Met Met Gln Gly Gly Val Tyr Gly Ser           
            105                 110                 115                   

ggt gga gaa agg tat gac tct tat gag tcc tgc gac tcg agg gcc gtc        498
Gly Gly Glu Arg Tyr Asp Ser Tyr Glu Ser Cys Asp Ser Arg Ala Val           
        120                 125                 130                       

ctg agt gag cgc gac ctg tac cgg tca ggc tat gac tac agc gag ctt        546
Leu Ser Glu Arg Asp Leu Tyr Arg Ser Gly Tyr Asp Tyr Ser Glu Leu           
    135                 140                 145                           

gac cct gag atg gaa atg gcc tat gag ggc caa tac gat gcc tac cgc        594
Asp Pro Glu Met Glu Met Ala Tyr Glu Gly Gln Tyr Asp Ala Tyr Arg           
150                 155                 160                 165           

gac cag ttc cgc atg cgt ggc aac gac acc ttc ggt ccc agg gca cag        642
Asp Gln Phe Arg Met Arg Gly Asn Asp Thr Phe Gly Pro Arg Ala Gln           
                170                 175                 180               

ggc tgg gcc cgg gat gcc cgg agc ggc cgg cca atg gcc tca ggc tat        690
Gly Trp Ala Arg Asp Ala Arg Ser Gly Arg Pro Met Ala Ser Gly Tyr           
            185                 190                 195                   

ggg cgc atg tgg gaa gac ccc atg ggg gcc cgg ggc cag tgc atg tct        738
Gly Arg Met Trp Glu Asp Pro Met Gly Ala Arg Gly Gln Cys Met Ser           
        200                 205                 210                       

ggt gcc tct cgg ctg ccc tcc ctc ttc tcc cag aac atc atc ccc gag        786
Gly Ala Ser Arg Leu Pro Ser Leu Phe Ser Gln Asn Ile Ile Pro Glu           
    215                 220                 225                           

tac ggc atg ttc cag ggc atg cga ggt ggg ggc gcc ttc ccg ggc ggc        834
Tyr Gly Met Phe Gln Gly Met Arg Gly Gly Gly Ala Phe Pro Gly Gly           
230                 235                 240                 245           

tcc cgc ttt ggt ttc ggg ttt ggc aat ggc atg aag cag atg agg cgg        882
Ser Arg Phe Gly Phe Gly Phe Gly Asn Gly Met Lys Gln Met Arg Arg           
                250                 255                 260               

acc tgg aag acc tgg acc aca gcc gac ttc cga acc aag aag aag aag        930
Thr Trp Lys Thr Trp Thr Thr Ala Asp Phe Arg Thr Lys Lys Lys Lys           
            265                 270                 275                   

aga aag cag ggc ggc agt cct gat gag cca gat agc aaa gcc acc cgc        978
Arg Lys Gln Gly Gly Ser Pro Asp Glu Pro Asp Ser Lys Ala Thr Arg           
        280                 285                 290                       

acg gac tgc tcg gac aac agc gac tca gac aat gat gag ggc acc gag       1026
Thr Asp Cys Ser Asp Asn Ser Asp Ser Asp Asn Asp Glu Gly Thr Glu           
    295                 300                 305                           

ggg gaa gcc aca gag ggc ctt gaa ggc acc gag gct gtg gag aag ggc       1074
Gly Glu Ala Thr Glu Gly Leu Glu Gly Thr Glu Ala Val Glu Lys Gly           
310                 315                 320                 325           

tcc aga gtg gac gga gag gat gag gag gga aaa gag gat ggg aga gaa       1122
Ser Arg Val Asp Gly Glu Asp Glu Glu Gly Lys Glu Asp Gly Arg Glu           
                330                 335                 340               

gaa ggc aaa gag gat cca gag aag ggg gcc cta acc acc cag gat gaa       1170
Glu Gly Lys Glu Asp Pro Glu Lys Gly Ala Leu Thr Thr Gln Asp Glu           
            345                 350                 355                   

aat ggc cag acc aag cgc aag ttg cag gca ggc aag aag agt cag gac       1218
Asn Gly Gln Thr Lys Arg Lys Leu Gln Ala Gly Lys Lys Ser Gln Asp           
        360                 365                 370                       

aag cag aaa aag cgg cag cga gac cgc atg gtg gaa agg atc cag ttt       1266
Lys Gln Lys Lys Arg Gln Arg Asp Arg Met Val Glu Arg Ile Gln Phe           
    375                 380                 385                           

gtg tgt tct ctg tgc aaa tac cgg acc ttc tat gag gac gag atg gcc       1314
Val Cys Ser Leu Cys Lys Tyr Arg Thr Phe Tyr Glu Asp Glu Met Ala           
390                 395                 400                 405           

agc cat ctt gac agc aag ttc cac aag gaa cac ttt aag tac gta ggc       1362
Ser His Leu Asp Ser Lys Phe His Lys Glu His Phe Lys Tyr Val Gly           
                410                 415                 420               

acc aag ctc cct aag cag acg gct gac ttt ctg cag gag tac gtc act       1410
Thr Lys Leu Pro Lys Gln Thr Ala Asp Phe Leu Gln Glu Tyr Val Thr           
            425                 430                 435                   

aac aag acc aag aag aca gag gag ctc cga aaa acc gtg gag gac ctt       1458
Asn Lys Thr Lys Lys Thr Glu Glu Leu Arg Lys Thr Val Glu Asp Leu           
        440                 445                 450                       

gat ggc ctc atc cac caa atc tac aga gac cag gat ctg acc cag gaa       1506
Asp Gly Leu Ile His Gln Ile Tyr Arg Asp Gln Asp Leu Thr Gln Glu           
    455                 460                 465                           

att gcc atg gag cat ttt gtg aag aag gtg gag gca gcc cat tgt gca       1554
Ile Ala Met Glu His Phe Val Lys Lys Val Glu Ala Ala His Cys Ala           
470                 475                 480                 485           

gcc tgc gac ctc ttc att ccc atg cag ttt ggg atc atc cag aag cat       1602
Ala Cys Asp Leu Phe Ile Pro Met Gln Phe Gly Ile Ile Gln Lys His           
                490                 495                 500               

ctg aag acc atg gat cac aac cgg aac cgc agg ctc atg atg gag cag       1650
Leu Lys Thr Met Asp His Asn Arg Asn Arg Arg Leu Met Met Glu Gln           
            505                 510                 515                   

tcc aag aag tcc tcc ctc atg gtg gcc cgc agt att ctc aac aac aag       1698
Ser Lys Lys Ser Ser Leu Met Val Ala Arg Ser Ile Leu Asn Asn Lys           
        520                 525                 530                       

ctc atc agc aag aag ctg gag cgc tac ctg aag ggc gag aac cct ttc       1746
Leu Ile Ser Lys Lys Leu Glu Arg Tyr Leu Lys Gly Glu Asn Pro Phe           
    535                 540                 545                           

acc gac agc ccc gag gag gag aag gag cag gag gag gct gag ggc ggt       1794
Thr Asp Ser Pro Glu Glu Glu Lys Glu Gln Glu Glu Ala Glu Gly Gly           
550                 555                 560                 565           

gcc ctg gac gag ggg gcg cag ggc gaa gcg gca ggg atc tcg gag ggc       1842
Ala Leu Asp Glu Gly Ala Gln Gly Glu Ala Ala Gly Ile Ser Glu Gly           
                570                 575                 580               

gca gag ggc gtg ccg gcg cag cct ccc gtg ccc cca gag cca gcc ccc       1890
Ala Glu Gly Val Pro Ala Gln Pro Pro Val Pro Pro Glu Pro Ala Pro           
            585                 590                 595                   

ggg gcc gtg tcg ccg cca ccg ccg ccg ccc cca gag gag gag gag gag       1938
Gly Ala Val Ser Pro Pro Pro Pro Pro Pro Pro Glu Glu Glu Glu Glu           
        600                 605                 610                       

ggc gcc gtg ccc ttg ctg gga ggg gcg ctg caa cgc cag atc cgc ggc       1986
Gly Ala Val Pro Leu Leu Gly Gly Ala Leu Gln Arg Gln Ile Arg Gly           
    615                 620                 625                           

atc ccg ggc ctc gac gtg gag gac gac gag gag ggc ggc ggg ggc gcc       2034
Ile Pro Gly Leu Asp Val Glu Asp Asp Glu Glu Gly Gly Gly Gly Ala           
630                 635                 640                 645           

ccg tga cccgagctcg gggcgggcgg agcccgcgtg gccgaagctg gaaaccaaac        2090
Pro                                                                       
                                                                          

ctaataaagt tttcccatcc caccaaaaaa aaaaaaaaaa aaaaaa                    2136


<210>  132
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Ser Tyr Thr Gly Phe Val Gln Gly Ser Glu Thr Thr Leu Gln Ser 
1               5                   10                  15      


Thr Tyr Ser Asp Thr Ser Ala Gln Pro Thr Cys Asp Tyr Gly Tyr Gly 
            20                  25                  30          


Thr Trp Asn Ser Gly Thr Asn Arg Gly Tyr Glu Gly Tyr Gly Tyr Gly 
        35                  40                  45              


Tyr Gly Tyr Gly Gln Asp Asn Thr Thr Asn Tyr Gly Tyr Gly Met Ala 
    50                  55                  60                  


Thr Ser His Ser Trp Glu Met Pro Ser Ser Asp Thr Asn Ala Asn Thr 
65                  70                  75                  80  


Ser Ala Ser Gly Ser Ala Ser Ala Asp Ser Val Leu Ser Arg Ile Asn 
                85                  90                  95      


Gln Arg Leu Asp Met Val Pro His Leu Glu Thr Asp Met Met Gln Gly 
            100                 105                 110         


Gly Val Tyr Gly Ser Gly Gly Glu Arg Tyr Asp Ser Tyr Glu Ser Cys 
        115                 120                 125             


Asp Ser Arg Ala Val Leu Ser Glu Arg Asp Leu Tyr Arg Ser Gly Tyr 
    130                 135                 140                 


Asp Tyr Ser Glu Leu Asp Pro Glu Met Glu Met Ala Tyr Glu Gly Gln 
145                 150                 155                 160 


Tyr Asp Ala Tyr Arg Asp Gln Phe Arg Met Arg Gly Asn Asp Thr Phe 
                165                 170                 175     


Gly Pro Arg Ala Gln Gly Trp Ala Arg Asp Ala Arg Ser Gly Arg Pro 
            180                 185                 190         


Met Ala Ser Gly Tyr Gly Arg Met Trp Glu Asp Pro Met Gly Ala Arg 
        195                 200                 205             


Gly Gln Cys Met Ser Gly Ala Ser Arg Leu Pro Ser Leu Phe Ser Gln 
    210                 215                 220                 


Asn Ile Ile Pro Glu Tyr Gly Met Phe Gln Gly Met Arg Gly Gly Gly 
225                 230                 235                 240 


Ala Phe Pro Gly Gly Ser Arg Phe Gly Phe Gly Phe Gly Asn Gly Met 
                245                 250                 255     


Lys Gln Met Arg Arg Thr Trp Lys Thr Trp Thr Thr Ala Asp Phe Arg 
            260                 265                 270         


Thr Lys Lys Lys Lys Arg Lys Gln Gly Gly Ser Pro Asp Glu Pro Asp 
        275                 280                 285             


Ser Lys Ala Thr Arg Thr Asp Cys Ser Asp Asn Ser Asp Ser Asp Asn 
    290                 295                 300                 


Asp Glu Gly Thr Glu Gly Glu Ala Thr Glu Gly Leu Glu Gly Thr Glu 
305                 310                 315                 320 


Ala Val Glu Lys Gly Ser Arg Val Asp Gly Glu Asp Glu Glu Gly Lys 
                325                 330                 335     


Glu Asp Gly Arg Glu Glu Gly Lys Glu Asp Pro Glu Lys Gly Ala Leu 
            340                 345                 350         


Thr Thr Gln Asp Glu Asn Gly Gln Thr Lys Arg Lys Leu Gln Ala Gly 
        355                 360                 365             


Lys Lys Ser Gln Asp Lys Gln Lys Lys Arg Gln Arg Asp Arg Met Val 
    370                 375                 380                 


Glu Arg Ile Gln Phe Val Cys Ser Leu Cys Lys Tyr Arg Thr Phe Tyr 
385                 390                 395                 400 


Glu Asp Glu Met Ala Ser His Leu Asp Ser Lys Phe His Lys Glu His 
                405                 410                 415     


Phe Lys Tyr Val Gly Thr Lys Leu Pro Lys Gln Thr Ala Asp Phe Leu 
            420                 425                 430         


Gln Glu Tyr Val Thr Asn Lys Thr Lys Lys Thr Glu Glu Leu Arg Lys 
        435                 440                 445             


Thr Val Glu Asp Leu Asp Gly Leu Ile His Gln Ile Tyr Arg Asp Gln 
    450                 455                 460                 


Asp Leu Thr Gln Glu Ile Ala Met Glu His Phe Val Lys Lys Val Glu 
465                 470                 475                 480 


Ala Ala His Cys Ala Ala Cys Asp Leu Phe Ile Pro Met Gln Phe Gly 
                485                 490                 495     


Ile Ile Gln Lys His Leu Lys Thr Met Asp His Asn Arg Asn Arg Arg 
            500                 505                 510         


Leu Met Met Glu Gln Ser Lys Lys Ser Ser Leu Met Val Ala Arg Ser 
        515                 520                 525             


Ile Leu Asn Asn Lys Leu Ile Ser Lys Lys Leu Glu Arg Tyr Leu Lys 
    530                 535                 540                 


Gly Glu Asn Pro Phe Thr Asp Ser Pro Glu Glu Glu Lys Glu Gln Glu 
545                 550                 555                 560 


Glu Ala Glu Gly Gly Ala Leu Asp Glu Gly Ala Gln Gly Glu Ala Ala 
                565                 570                 575     


Gly Ile Ser Glu Gly Ala Glu Gly Val Pro Ala Gln Pro Pro Val Pro 
            580                 585                 590         


Pro Glu Pro Ala Pro Gly Ala Val Ser Pro Pro Pro Pro Pro Pro Pro 
        595                 600                 605             


Glu Glu Glu Glu Glu Gly Ala Val Pro Leu Leu Gly Gly Ala Leu Gln 
    610                 615                 620                 


Arg Gln Ile Arg Gly Ile Pro Gly Leu Asp Val Glu Asp Asp Glu Glu 
625                 630                 635                 640 


Gly Gly Gly Gly Ala Pro 
                645     


<210>  133
<211>  562
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (109)..(393)

<400>  133
ctggaattga ggctgagcca aagaccccag ggccgtctca gtctcataaa aggggatcag       60

gcaggaggag tttgggagaa acctgagaag ggcctgattt gcagcatc atg atg ggc       117
                                                     Met Met Gly          
                                                     1                    

ctc tcc ttg gcc tct gct gtg ctc ctg gcc tcc ctc ctg agt ctc cac        165
Leu Ser Leu Ala Ser Ala Val Leu Leu Ala Ser Leu Leu Ser Leu His           
    5                   10                  15                            

ctt gga act gcc aca cgt ggg agt gac ata tcc aag acc tgc tgc ttc        213
Leu Gly Thr Ala Thr Arg Gly Ser Asp Ile Ser Lys Thr Cys Cys Phe           
20                  25                  30                  35            

caa tac agc cac aag ccc ctt ccc tgg acc tgg gtg cga agc tat gaa        261
Gln Tyr Ser His Lys Pro Leu Pro Trp Thr Trp Val Arg Ser Tyr Glu           
                40                  45                  50                

ttc acc agt aac agc tgc tcc cag cgg gct gtg ata ttc act acc aaa        309
Phe Thr Ser Asn Ser Cys Ser Gln Arg Ala Val Ile Phe Thr Thr Lys           
            55                  60                  65                    

aga ggc aag aaa gtc tgt acc cat cca agg aaa aaa tgg gtg caa aaa        357
Arg Gly Lys Lys Val Cys Thr His Pro Arg Lys Lys Trp Val Gln Lys           
        70                  75                  80                        

tac att tct tta ctg aaa act ccg aaa caa ttg tga ctcagctgaa             403
Tyr Ile Ser Leu Leu Lys Thr Pro Lys Gln Leu                               
    85                  90                                                

ttttcatccg aggacgcttg gaccccgctc ttggctctgc agccctctgg ggagcctgcg      463

gaatcttttc tgaaggctac atggacccgc tggggaggag agggtgtttc ctcccagagt      523

tactttaata aaggttgttc atagagttga cttgttcat                             562


<210>  134
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Met Gly Leu Ser Leu Ala Ser Ala Val Leu Leu Ala Ser Leu Leu 
1               5                   10                  15      


Ser Leu His Leu Gly Thr Ala Thr Arg Gly Ser Asp Ile Ser Lys Thr 
            20                  25                  30          


Cys Cys Phe Gln Tyr Ser His Lys Pro Leu Pro Trp Thr Trp Val Arg 
        35                  40                  45              


Ser Tyr Glu Phe Thr Ser Asn Ser Cys Ser Gln Arg Ala Val Ile Phe 
    50                  55                  60                  


Thr Thr Lys Arg Gly Lys Lys Val Cys Thr His Pro Arg Lys Lys Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Ile Ser Leu Leu Lys Thr Pro Lys Gln Leu 
                85                  90                  


<210>  135
<211>  4837
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (275)..(4525)

<400>  135
gcggctgcgt cagggattcc ttggtggccc tggagggtgg ataggctggc ctgggggcca       60

tcaggacagc aggtgacggt caggccaatg ccagccgggc ctgggcacag ccctgtgggg      120

gcttcggagg gccctgagga ggaggaggaa gaggcagagg agagaaggcc ccacggaggt      180

cctgtcgcca gcgctgccac tgcctgacct ccgctgcccg aaggccggtg ggcctctgtg      240

gcctccgtga agcaggcccg gctgtcgtca ggcc atg tct ggt cca tgg ccc tcc      295
                                      Met Ser Gly Pro Trp Pro Ser         
                                      1               5                   

ccc gac agc cgg acc aag gga acg gtg gcc tgg ctg gcg gag gta ctc        343
Pro Asp Ser Arg Thr Lys Gly Thr Val Ala Trp Leu Ala Glu Val Leu           
        10                  15                  20                        

ctc tgg gtt gga ggg agt gtg gtg ctg tct tca gag tgg cag ctc ggc        391
Leu Trp Val Gly Gly Ser Val Val Leu Ser Ser Glu Trp Gln Leu Gly           
    25                  30                  35                            

ccc ctg gtg gag cgg tgc atg ggt gcc atg caa gag ggg atg cag atg        439
Pro Leu Val Glu Arg Cys Met Gly Ala Met Gln Glu Gly Met Gln Met           
40                  45                  50                  55            

gtg aag ctg cgt ggc ggc tcc aag ggc ctg gtc cgc ttc tac tac ctg        487
Val Lys Leu Arg Gly Gly Ser Lys Gly Leu Val Arg Phe Tyr Tyr Leu           
                60                  65                  70                

gac gag cac cgc tcc tgc atc cgc tgg agg ccc tca cgc aag aac gag        535
Asp Glu His Arg Ser Cys Ile Arg Trp Arg Pro Ser Arg Lys Asn Glu           
            75                  80                  85                    

aag gcc aag atc tcc atc gac tcc atc cag gag gtg agt gag ggg cgg        583
Lys Ala Lys Ile Ser Ile Asp Ser Ile Gln Glu Val Ser Glu Gly Arg           
        90                  95                  100                       

cag tcg gag gtc ttc cag cgc tac cct gac ggc agc ttc gac ccc aac        631
Gln Ser Glu Val Phe Gln Arg Tyr Pro Asp Gly Ser Phe Asp Pro Asn           
    105                 110                 115                           

tgc tgc ttc agc atc tac cac ggc agc cac cgc gag tcg ctg gac ctg        679
Cys Cys Phe Ser Ile Tyr His Gly Ser His Arg Glu Ser Leu Asp Leu           
120                 125                 130                 135           

gtc tcc acc agc agc gag gtg gcg cgc acc tgg gtc act ggc ctg cgc        727
Val Ser Thr Ser Ser Glu Val Ala Arg Thr Trp Val Thr Gly Leu Arg           
                140                 145                 150               

tac ctc atg gcc ggc atc agc gac gag gac agc ctg gct cgc cgc cag        775
Tyr Leu Met Ala Gly Ile Ser Asp Glu Asp Ser Leu Ala Arg Arg Gln           
            155                 160                 165                   

cgc acc agg gac cag tgg ctg aag cag acg ttt gac gag gcc gac aag        823
Arg Thr Arg Asp Gln Trp Leu Lys Gln Thr Phe Asp Glu Ala Asp Lys           
        170                 175                 180                       

aac ggg gat ggc agc ctg agc att ggc gag gtc ctg cag ctg ctg cac        871
Asn Gly Asp Gly Ser Leu Ser Ile Gly Glu Val Leu Gln Leu Leu His           
    185                 190                 195                           

aag ctc aac gtg aac ctg ccc cgg cag agg gtg aag cag atg ttc agg        919
Lys Leu Asn Val Asn Leu Pro Arg Gln Arg Val Lys Gln Met Phe Arg           
200                 205                 210                 215           

gaa gcg gac acg gat gac cac caa ggg acg ctg ggt ttt gaa gag ttc        967
Glu Ala Asp Thr Asp Asp His Gln Gly Thr Leu Gly Phe Glu Glu Phe           
                220                 225                 230               

tgt gcc ttc tac aag atg atg tcc acc cgc cgg gac ctc tac ctg ctc       1015
Cys Ala Phe Tyr Lys Met Met Ser Thr Arg Arg Asp Leu Tyr Leu Leu           
            235                 240                 245                   

atg ctg acc tac agc aac cac aag gac cac ctg gat gcc gcc agc ctg       1063
Met Leu Thr Tyr Ser Asn His Lys Asp His Leu Asp Ala Ala Ser Leu           
        250                 255                 260                       

cag cgc ttc ctg cag gtg gag cag aag atg gcg ggt gtg acc ctc gag       1111
Gln Arg Phe Leu Gln Val Glu Gln Lys Met Ala Gly Val Thr Leu Glu           
    265                 270                 275                           

agc tgc cag gac atc atc gag cag ttt gag cca tgc cca gaa aac aag       1159
Ser Cys Gln Asp Ile Ile Glu Gln Phe Glu Pro Cys Pro Glu Asn Lys           
280                 285                 290                 295           

agt aag ggg ctg ctg ggc att gat ggc ttc acc aac tac acc agg agc       1207
Ser Lys Gly Leu Leu Gly Ile Asp Gly Phe Thr Asn Tyr Thr Arg Ser           
                300                 305                 310               

cct gct ggt gac atc ttc aac cct gag cac cac cat gtg cac cag gac       1255
Pro Ala Gly Asp Ile Phe Asn Pro Glu His His His Val His Gln Asp           
            315                 320                 325                   

atg acg cag ccg ctg agc cac tac ttc atc acc tcg tcc cac aac acc       1303
Met Thr Gln Pro Leu Ser His Tyr Phe Ile Thr Ser Ser His Asn Thr           
        330                 335                 340                       

tac ctc gtg ggt gac cag ctc atg tcc cag tca cgg gtg gac atg tat       1351
Tyr Leu Val Gly Asp Gln Leu Met Ser Gln Ser Arg Val Asp Met Tyr           
    345                 350                 355                           

gct tgg gtc ctg cag gct ggc tgc cgc tgc gtg gag gtg gac tgc tgg       1399
Ala Trp Val Leu Gln Ala Gly Cys Arg Cys Val Glu Val Asp Cys Trp           
360                 365                 370                 375           

gat ggg ccc gac ggg gag ccc att gtg cac cat ggc tac act ctg act       1447
Asp Gly Pro Asp Gly Glu Pro Ile Val His His Gly Tyr Thr Leu Thr           
                380                 385                 390               

tcc aag atc ctc ttc aaa gac gtc att gaa acc atc aac aaa tat gcc       1495
Ser Lys Ile Leu Phe Lys Asp Val Ile Glu Thr Ile Asn Lys Tyr Ala           
            395                 400                 405                   

ttc atc aag aat gag tac cca gtg atc ctg tcc atc gaa aac cac tgc       1543
Phe Ile Lys Asn Glu Tyr Pro Val Ile Leu Ser Ile Glu Asn His Cys           
        410                 415                 420                       

agt gtc atc cag cag aag aaa atg gcc cag tat ctg act gac atc ctt       1591
Ser Val Ile Gln Gln Lys Lys Met Ala Gln Tyr Leu Thr Asp Ile Leu           
    425                 430                 435                           

ggg gac aag ctg gac ctg tca tca gtg agc agt gaa gat gcc acc aca       1639
Gly Asp Lys Leu Asp Leu Ser Ser Val Ser Ser Glu Asp Ala Thr Thr           
440                 445                 450                 455           

ctc ccc tct cca cag atg ctc aag ggc aag atc ctc gtg aag ggg aag       1687
Leu Pro Ser Pro Gln Met Leu Lys Gly Lys Ile Leu Val Lys Gly Lys           
                460                 465                 470               

aag ctc cca gcc aac atc agc gag gat gcg gag gaa ggc gag gtg tct       1735
Lys Leu Pro Ala Asn Ile Ser Glu Asp Ala Glu Glu Gly Glu Val Ser           
            475                 480                 485                   

gat gag gac agt gct gat gag att gac gat gac tgc aag ctc ctc aat       1783
Asp Glu Asp Ser Ala Asp Glu Ile Asp Asp Asp Cys Lys Leu Leu Asn           
        490                 495                 500                       

ggg gat gca tcc acc aat cga aag cgt gta gaa aac act gct aag agg       1831
Gly Asp Ala Ser Thr Asn Arg Lys Arg Val Glu Asn Thr Ala Lys Arg           
    505                 510                 515                           

aaa ctg gat tcc ctc atc aaa gag tcg aag att cgg gac tgt gag gac       1879
Lys Leu Asp Ser Leu Ile Lys Glu Ser Lys Ile Arg Asp Cys Glu Asp           
520                 525                 530                 535           

ccc aac aac ttc tcc gtc tcc aca ctg tcc cca tct gga aag ctc gga       1927
Pro Asn Asn Phe Ser Val Ser Thr Leu Ser Pro Ser Gly Lys Leu Gly           
                540                 545                 550               

cgc aag agc aag gct gaa gag gac gtg gag tct ggg gag gat gcc ggg       1975
Arg Lys Ser Lys Ala Glu Glu Asp Val Glu Ser Gly Glu Asp Ala Gly           
            555                 560                 565                   

gcc agc aga cgc aat ggc cgc ctc gtc gtg gga agc ttc tcc agg cgc       2023
Ala Ser Arg Arg Asn Gly Arg Leu Val Val Gly Ser Phe Ser Arg Arg           
        570                 575                 580                       

aag aag aag ggc agc aag ctg aag aag gcg gcc agc gtg gag gag gga       2071
Lys Lys Lys Gly Ser Lys Leu Lys Lys Ala Ala Ser Val Glu Glu Gly           
    585                 590                 595                           

gat gag ggt cag gac tcc ccg gga ggc cag agc cga ggg gcg acc cgg       2119
Asp Glu Gly Gln Asp Ser Pro Gly Gly Gln Ser Arg Gly Ala Thr Arg           
600                 605                 610                 615           

cag aag aag acc atg aag ctg tcc cgg gcc ctc tct gac ctg gtg aag       2167
Gln Lys Lys Thr Met Lys Leu Ser Arg Ala Leu Ser Asp Leu Val Lys           
                620                 625                 630               

tac acc aag tcc gtg gcc acc cac gac ata gag atg gag gcg gcg tcc       2215
Tyr Thr Lys Ser Val Ala Thr His Asp Ile Glu Met Glu Ala Ala Ser           
            635                 640                 645                   

agc tgg cag gtg tcg tcc ttc agc gag acc aag gcc cac cag att ctg       2263
Ser Trp Gln Val Ser Ser Phe Ser Glu Thr Lys Ala His Gln Ile Leu           
        650                 655                 660                       

cag cag aag ccg gcg cag tac cta cgc ttc aac cag cag cag ctc tcc       2311
Gln Gln Lys Pro Ala Gln Tyr Leu Arg Phe Asn Gln Gln Gln Leu Ser           
    665                 670                 675                           

cgc atc tac ccc tcc tcc tac cgt gtg gac tcc agc aac tac aac ccg       2359
Arg Ile Tyr Pro Ser Ser Tyr Arg Val Asp Ser Ser Asn Tyr Asn Pro           
680                 685                 690                 695           

cag ccc ttc tgg aac gcc ggc tgc caa atg gtt gcc ctg aac tac cag       2407
Gln Pro Phe Trp Asn Ala Gly Cys Gln Met Val Ala Leu Asn Tyr Gln           
                700                 705                 710               

tca gag ggg cgg atg ctg cag ctg aac cga gcc aag ttc agc gcc aac       2455
Ser Glu Gly Arg Met Leu Gln Leu Asn Arg Ala Lys Phe Ser Ala Asn           
            715                 720                 725                   

ggt ggc tgc ggc tac gta ctc aag cct ggg tgc atg tgc cag ggc gtg       2503
Gly Gly Cys Gly Tyr Val Leu Lys Pro Gly Cys Met Cys Gln Gly Val           
        730                 735                 740                       

ttc aac ccc aac tcg gag gac ccc ctg ccc ggg cag ctc aag aag cag       2551
Phe Asn Pro Asn Ser Glu Asp Pro Leu Pro Gly Gln Leu Lys Lys Gln           
    745                 750                 755                           

ctg gtg ctc cgg atc atc agt ggc cag cag ctt ccc aag ccg cgc gac       2599
Leu Val Leu Arg Ile Ile Ser Gly Gln Gln Leu Pro Lys Pro Arg Asp           
760                 765                 770                 775           

tcc atg ctg ggg gac cgt ggg gag atc atc gac ccc ttt gtg gag gtg       2647
Ser Met Leu Gly Asp Arg Gly Glu Ile Ile Asp Pro Phe Val Glu Val           
                780                 785                 790               

gag atc att ggg ctc cct gtg gac tgc agc agg gag cag acc cgc gtg       2695
Glu Ile Ile Gly Leu Pro Val Asp Cys Ser Arg Glu Gln Thr Arg Val           
            795                 800                 805                   

gtg gac gac aac ggg ttc aac ccc acc tgg gag gag acc ctg gtt ttc       2743
Val Asp Asp Asn Gly Phe Asn Pro Thr Trp Glu Glu Thr Leu Val Phe           
        810                 815                 820                       

atg gtg cac atg ccg gag atc gcg ctg gtc cgc ttc ctc gtc tgg gac       2791
Met Val His Met Pro Glu Ile Ala Leu Val Arg Phe Leu Val Trp Asp           
    825                 830                 835                           

cac gat ccc att ggg cgt gac ttc att ggc cag agg acg ctg gcc ttc       2839
His Asp Pro Ile Gly Arg Asp Phe Ile Gly Gln Arg Thr Leu Ala Phe           
840                 845                 850                 855           

agc agc atg atg cca ggc tac aga cac gtg tac cta gaa ggg atg gaa       2887
Ser Ser Met Met Pro Gly Tyr Arg His Val Tyr Leu Glu Gly Met Glu           
                860                 865                 870               

gag gcc tcc atc ttc gtg cat gtg gct gtc agt gac atc agc ggt aag       2935
Glu Ala Ser Ile Phe Val His Val Ala Val Ser Asp Ile Ser Gly Lys           
            875                 880                 885                   

gtc aag cag gct ctg ggc cta aaa ggc ctc ttc ctc cga ggc cca aag       2983
Val Lys Gln Ala Leu Gly Leu Lys Gly Leu Phe Leu Arg Gly Pro Lys           
        890                 895                 900                       

ccc ggc tcg ctg gac agt cat gct gct ggg cgg ccc ccg gcc cgg ccc       3031
Pro Gly Ser Leu Asp Ser His Ala Ala Gly Arg Pro Pro Ala Arg Pro           
    905                 910                 915                           

tcc gtt agc cag cgg atc ctg cgg cgc acg gcc agc gcc ccg acc aag       3079
Ser Val Ser Gln Arg Ile Leu Arg Arg Thr Ala Ser Ala Pro Thr Lys           
920                 925                 930                 935           

agc cag aag ccg ggc cgc agg ggc ttc ccg gag ctg gtc ctg ggt aca       3127
Ser Gln Lys Pro Gly Arg Arg Gly Phe Pro Glu Leu Val Leu Gly Thr           
                940                 945                 950               

cgg gac aca ggc tcc aag ggg gtg gca gac gat gtg gtg ccc ccc ggg       3175
Arg Asp Thr Gly Ser Lys Gly Val Ala Asp Asp Val Val Pro Pro Gly           
            955                 960                 965                   

ccc gga cct gct ccg gaa gcc cca gcc cag gag ggg ccc ggc agc ggc       3223
Pro Gly Pro Ala Pro Glu Ala Pro Ala Gln Glu Gly Pro Gly Ser Gly           
        970                 975                 980                       

agc ccc cga gac acc cgc ccc ctc tcc acg cag cgg cca ctc ccc cca       3271
Ser Pro Arg Asp Thr Arg Pro Leu Ser Thr Gln Arg Pro Leu Pro Pro           
    985                 990                 995                           

ctg  tgc agc ctg gaa acc  atc gct gag gag ccc  gcc cca ggc cct        3316
Leu  Cys Ser Leu Glu Thr  Ile Ala Glu Glu Pro  Ala Pro Gly Pro            
1000                 1005                 1010                            

ggt  ccc ccg cca cca gcg  gct gtc ccc acc agc  tct tct cag gga        3361
Gly  Pro Pro Pro Pro Ala  Ala Val Pro Thr Ser  Ser Ser Gln Gly            
1015                 1020                 1025                            

cgg  ccc cca tac ccc aca  gga ccc gga gcc aat  gtg gca agc ccc        3406
Arg  Pro Pro Tyr Pro Thr  Gly Pro Gly Ala Asn  Val Ala Ser Pro            
1030                 1035                 1040                            

cta  gag gac act gag gag  ccc cga gac agc agg  cct cgg ccg tgc        3451
Leu  Glu Asp Thr Glu Glu  Pro Arg Asp Ser Arg  Pro Arg Pro Cys            
1045                 1050                 1055                            

aac  ggc gag ggc gcc ggc  ggg gca tac gag agg  gcc ccc ggc agc        3496
Asn  Gly Glu Gly Ala Gly  Gly Ala Tyr Glu Arg  Ala Pro Gly Ser            
1060                 1065                 1070                            

cag  acg gac ggc agg agc  cag ccc cgg acc ctg  ggc cac ctg ccc        3541
Gln  Thr Asp Gly Arg Ser  Gln Pro Arg Thr Leu  Gly His Leu Pro            
1075                 1080                 1085                            

gtg  att aga agg gtg aag  agt gag ggg cag gtg  ccc acg gag ccc        3586
Val  Ile Arg Arg Val Lys  Ser Glu Gly Gln Val  Pro Thr Glu Pro            
1090                 1095                 1100                            

ctg  gga ggg tgg cgg ccc  ctg gcc gct ccc ttt  cca gct cct gcc        3631
Leu  Gly Gly Trp Arg Pro  Leu Ala Ala Pro Phe  Pro Ala Pro Ala            
1105                 1110                 1115                            

gtg  tac tcc gat gcc acg  ggc agt gac ccg ctg  tgg cag cgg ctg        3676
Val  Tyr Ser Asp Ala Thr  Gly Ser Asp Pro Leu  Trp Gln Arg Leu            
1120                 1125                 1130                            

gag  cca tgt ggc cac cga  gac agc gtt tcc tcc  tcc tcc agc atg        3721
Glu  Pro Cys Gly His Arg  Asp Ser Val Ser Ser  Ser Ser Ser Met            
1135                 1140                 1145                            

tca  tcc agc gac act gtc  att gac ctc tcc ctg  ccc agc ctg ggc        3766
Ser  Ser Ser Asp Thr Val  Ile Asp Leu Ser Leu  Pro Ser Leu Gly            
1150                 1155                 1160                            

ctg  ggc cgc agc cgt gag  aac ctc gct gga gcc  cac atg gga cgc        3811
Leu  Gly Arg Ser Arg Glu  Asn Leu Ala Gly Ala  His Met Gly Arg            
1165                 1170                 1175                            

ctg  ccc ccc agg ccc cac  tcg gct tcg gct gcc  cgc cca gac ctg        3856
Leu  Pro Pro Arg Pro His  Ser Ala Ser Ala Ala  Arg Pro Asp Leu            
1180                 1185                 1190                            

cca  cct gtg acc aag agc  aaa tcc aac ccc aac  ctt cgg gct aca        3901
Pro  Pro Val Thr Lys Ser  Lys Ser Asn Pro Asn  Leu Arg Ala Thr            
1195                 1200                 1205                            

ggc  cag cgg cct ccc ata  cct gac gaa ctg cag  ccc agg tcc ctg        3946
Gly  Gln Arg Pro Pro Ile  Pro Asp Glu Leu Gln  Pro Arg Ser Leu            
1210                 1215                 1220                            

gcc  cca agg atg gct ggc  ctc ccc ttc cgg cct  ccc tgg ggc tgc        3991
Ala  Pro Arg Met Ala Gly  Leu Pro Phe Arg Pro  Pro Trp Gly Cys            
1225                 1230                 1235                            

ctt  tcc ctg gtg ggc gtg  cag gac tgc ccc gtg  gct gcc aag tcc        4036
Leu  Ser Leu Val Gly Val  Gln Asp Cys Pro Val  Ala Ala Lys Ser            
1240                 1245                 1250                            

aag  agc ctg ggc gac ctc  act gct gat gac ttt  gcc cct agc ttt        4081
Lys  Ser Leu Gly Asp Leu  Thr Ala Asp Asp Phe  Ala Pro Ser Phe            
1255                 1260                 1265                            

gag  ggc ggc tcc cgc aga  ctg agc cac agc ctg  ggc ctc ccg gga        4126
Glu  Gly Gly Ser Arg Arg  Leu Ser His Ser Leu  Gly Leu Pro Gly            
1270                 1275                 1280                            

ggg  aca cgg cgg gtg tcg  ggg cca ggg gtg aga  cgg gac acc ctg        4171
Gly  Thr Arg Arg Val Ser  Gly Pro Gly Val Arg  Arg Asp Thr Leu            
1285                 1290                 1295                            

aca  gag cag ctg cgc tgg  ctc act gtc ttc cag  cag gca gga gac        4216
Thr  Glu Gln Leu Arg Trp  Leu Thr Val Phe Gln  Gln Ala Gly Asp            
1300                 1305                 1310                            

atc  acg tca ccc acc agc  ctg ggc ccg gct ggg  gag ggg gtg gca        4261
Ile  Thr Ser Pro Thr Ser  Leu Gly Pro Ala Gly  Glu Gly Val Ala            
1315                 1320                 1325                            

ggg  ggc cct ggt ttt gtg  cgg cgc tcc tcc tcc  cgc agc cac agc        4306
Gly  Gly Pro Gly Phe Val  Arg Arg Ser Ser Ser  Arg Ser His Ser            
1330                 1335                 1340                            

cgc  gtg cgt gcc att gcc  agc cgg gcc cgc cag  gcc cag gag cgg        4351
Arg  Val Arg Ala Ile Ala  Ser Arg Ala Arg Gln  Ala Gln Glu Arg            
1345                 1350                 1355                            

cag  cag aga ctg cag ggc  ctg ggc cgg cag gga  ccc cca gaa gag        4396
Gln  Gln Arg Leu Gln Gly  Leu Gly Arg Gln Gly  Pro Pro Glu Glu            
1360                 1365                 1370                            

gag  cgg ggc acc ccc gag  ggc gcc tgc tcc gtg  ggc cac gag ggc        4441
Glu  Arg Gly Thr Pro Glu  Gly Ala Cys Ser Val  Gly His Glu Gly            
1375                 1380                 1385                            

agt  gtg gat gca cca gca  ccc tcc aag gga gcc  ctc ggg cca gca        4486
Ser  Val Asp Ala Pro Ala  Pro Ser Lys Gly Ala  Leu Gly Pro Ala            
1390                 1395                 1400                            

tcc  gcg gct gct gaa aac  ctg gtc ctg ctc cgc  ctc tga ccgtcagtgg     4535
Ser  Ala Ala Ala Glu Asn  Leu Val Leu Leu Arg  Leu                        
1405                 1410                 1415                            

tgggaacctg ggcggctctg gaggcccagg gcaggggtgg gcgtgttgtt tgctcaggaa     4595

acagggcagc caggccccca aaactgtgtc cccctggctg ccctgtgtcc cctccacccc     4655

tgcctccctc ctgcccctgc tcccggggag gaaaggctaa agctgctggc ccggggccca     4715

caggaggggc ttcgaggctg gccctgccag gcagttttcc cggcgtttta ggatctgtac     4775

atagagaaat atttaaattt ttagaagcaa aacttataca acattaaaat gataccaagt     4835

cc                                                                    4837


<210>  136
<211>  1416
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Ser Gly Pro Trp Pro Ser Pro Asp Ser Arg Thr Lys Gly Thr Val 
1               5                   10                  15      


Ala Trp Leu Ala Glu Val Leu Leu Trp Val Gly Gly Ser Val Val Leu 
            20                  25                  30          


Ser Ser Glu Trp Gln Leu Gly Pro Leu Val Glu Arg Cys Met Gly Ala 
        35                  40                  45              


Met Gln Glu Gly Met Gln Met Val Lys Leu Arg Gly Gly Ser Lys Gly 
    50                  55                  60                  


Leu Val Arg Phe Tyr Tyr Leu Asp Glu His Arg Ser Cys Ile Arg Trp 
65                  70                  75                  80  


Arg Pro Ser Arg Lys Asn Glu Lys Ala Lys Ile Ser Ile Asp Ser Ile 
                85                  90                  95      


Gln Glu Val Ser Glu Gly Arg Gln Ser Glu Val Phe Gln Arg Tyr Pro 
            100                 105                 110         


Asp Gly Ser Phe Asp Pro Asn Cys Cys Phe Ser Ile Tyr His Gly Ser 
        115                 120                 125             


His Arg Glu Ser Leu Asp Leu Val Ser Thr Ser Ser Glu Val Ala Arg 
    130                 135                 140                 


Thr Trp Val Thr Gly Leu Arg Tyr Leu Met Ala Gly Ile Ser Asp Glu 
145                 150                 155                 160 


Asp Ser Leu Ala Arg Arg Gln Arg Thr Arg Asp Gln Trp Leu Lys Gln 
                165                 170                 175     


Thr Phe Asp Glu Ala Asp Lys Asn Gly Asp Gly Ser Leu Ser Ile Gly 
            180                 185                 190         


Glu Val Leu Gln Leu Leu His Lys Leu Asn Val Asn Leu Pro Arg Gln 
        195                 200                 205             


Arg Val Lys Gln Met Phe Arg Glu Ala Asp Thr Asp Asp His Gln Gly 
    210                 215                 220                 


Thr Leu Gly Phe Glu Glu Phe Cys Ala Phe Tyr Lys Met Met Ser Thr 
225                 230                 235                 240 


Arg Arg Asp Leu Tyr Leu Leu Met Leu Thr Tyr Ser Asn His Lys Asp 
                245                 250                 255     


His Leu Asp Ala Ala Ser Leu Gln Arg Phe Leu Gln Val Glu Gln Lys 
            260                 265                 270         


Met Ala Gly Val Thr Leu Glu Ser Cys Gln Asp Ile Ile Glu Gln Phe 
        275                 280                 285             


Glu Pro Cys Pro Glu Asn Lys Ser Lys Gly Leu Leu Gly Ile Asp Gly 
    290                 295                 300                 


Phe Thr Asn Tyr Thr Arg Ser Pro Ala Gly Asp Ile Phe Asn Pro Glu 
305                 310                 315                 320 


His His His Val His Gln Asp Met Thr Gln Pro Leu Ser His Tyr Phe 
                325                 330                 335     


Ile Thr Ser Ser His Asn Thr Tyr Leu Val Gly Asp Gln Leu Met Ser 
            340                 345                 350         


Gln Ser Arg Val Asp Met Tyr Ala Trp Val Leu Gln Ala Gly Cys Arg 
        355                 360                 365             


Cys Val Glu Val Asp Cys Trp Asp Gly Pro Asp Gly Glu Pro Ile Val 
    370                 375                 380                 


His His Gly Tyr Thr Leu Thr Ser Lys Ile Leu Phe Lys Asp Val Ile 
385                 390                 395                 400 


Glu Thr Ile Asn Lys Tyr Ala Phe Ile Lys Asn Glu Tyr Pro Val Ile 
                405                 410                 415     


Leu Ser Ile Glu Asn His Cys Ser Val Ile Gln Gln Lys Lys Met Ala 
            420                 425                 430         


Gln Tyr Leu Thr Asp Ile Leu Gly Asp Lys Leu Asp Leu Ser Ser Val 
        435                 440                 445             


Ser Ser Glu Asp Ala Thr Thr Leu Pro Ser Pro Gln Met Leu Lys Gly 
    450                 455                 460                 


Lys Ile Leu Val Lys Gly Lys Lys Leu Pro Ala Asn Ile Ser Glu Asp 
465                 470                 475                 480 


Ala Glu Glu Gly Glu Val Ser Asp Glu Asp Ser Ala Asp Glu Ile Asp 
                485                 490                 495     


Asp Asp Cys Lys Leu Leu Asn Gly Asp Ala Ser Thr Asn Arg Lys Arg 
            500                 505                 510         


Val Glu Asn Thr Ala Lys Arg Lys Leu Asp Ser Leu Ile Lys Glu Ser 
        515                 520                 525             


Lys Ile Arg Asp Cys Glu Asp Pro Asn Asn Phe Ser Val Ser Thr Leu 
    530                 535                 540                 


Ser Pro Ser Gly Lys Leu Gly Arg Lys Ser Lys Ala Glu Glu Asp Val 
545                 550                 555                 560 


Glu Ser Gly Glu Asp Ala Gly Ala Ser Arg Arg Asn Gly Arg Leu Val 
                565                 570                 575     


Val Gly Ser Phe Ser Arg Arg Lys Lys Lys Gly Ser Lys Leu Lys Lys 
            580                 585                 590         


Ala Ala Ser Val Glu Glu Gly Asp Glu Gly Gln Asp Ser Pro Gly Gly 
        595                 600                 605             


Gln Ser Arg Gly Ala Thr Arg Gln Lys Lys Thr Met Lys Leu Ser Arg 
    610                 615                 620                 


Ala Leu Ser Asp Leu Val Lys Tyr Thr Lys Ser Val Ala Thr His Asp 
625                 630                 635                 640 


Ile Glu Met Glu Ala Ala Ser Ser Trp Gln Val Ser Ser Phe Ser Glu 
                645                 650                 655     


Thr Lys Ala His Gln Ile Leu Gln Gln Lys Pro Ala Gln Tyr Leu Arg 
            660                 665                 670         


Phe Asn Gln Gln Gln Leu Ser Arg Ile Tyr Pro Ser Ser Tyr Arg Val 
        675                 680                 685             


Asp Ser Ser Asn Tyr Asn Pro Gln Pro Phe Trp Asn Ala Gly Cys Gln 
    690                 695                 700                 


Met Val Ala Leu Asn Tyr Gln Ser Glu Gly Arg Met Leu Gln Leu Asn 
705                 710                 715                 720 


Arg Ala Lys Phe Ser Ala Asn Gly Gly Cys Gly Tyr Val Leu Lys Pro 
                725                 730                 735     


Gly Cys Met Cys Gln Gly Val Phe Asn Pro Asn Ser Glu Asp Pro Leu 
            740                 745                 750         


Pro Gly Gln Leu Lys Lys Gln Leu Val Leu Arg Ile Ile Ser Gly Gln 
        755                 760                 765             


Gln Leu Pro Lys Pro Arg Asp Ser Met Leu Gly Asp Arg Gly Glu Ile 
    770                 775                 780                 


Ile Asp Pro Phe Val Glu Val Glu Ile Ile Gly Leu Pro Val Asp Cys 
785                 790                 795                 800 


Ser Arg Glu Gln Thr Arg Val Val Asp Asp Asn Gly Phe Asn Pro Thr 
                805                 810                 815     


Trp Glu Glu Thr Leu Val Phe Met Val His Met Pro Glu Ile Ala Leu 
            820                 825                 830         


Val Arg Phe Leu Val Trp Asp His Asp Pro Ile Gly Arg Asp Phe Ile 
        835                 840                 845             


Gly Gln Arg Thr Leu Ala Phe Ser Ser Met Met Pro Gly Tyr Arg His 
    850                 855                 860                 


Val Tyr Leu Glu Gly Met Glu Glu Ala Ser Ile Phe Val His Val Ala 
865                 870                 875                 880 


Val Ser Asp Ile Ser Gly Lys Val Lys Gln Ala Leu Gly Leu Lys Gly 
                885                 890                 895     


Leu Phe Leu Arg Gly Pro Lys Pro Gly Ser Leu Asp Ser His Ala Ala 
            900                 905                 910         


Gly Arg Pro Pro Ala Arg Pro Ser Val Ser Gln Arg Ile Leu Arg Arg 
        915                 920                 925             


Thr Ala Ser Ala Pro Thr Lys Ser Gln Lys Pro Gly Arg Arg Gly Phe 
    930                 935                 940                 


Pro Glu Leu Val Leu Gly Thr Arg Asp Thr Gly Ser Lys Gly Val Ala 
945                 950                 955                 960 


Asp Asp Val Val Pro Pro Gly Pro Gly Pro Ala Pro Glu Ala Pro Ala 
                965                 970                 975     


Gln Glu Gly Pro Gly Ser Gly Ser Pro Arg Asp Thr Arg Pro Leu Ser 
            980                 985                 990         


Thr Gln Arg Pro Leu Pro Pro Leu  Cys Ser Leu Glu Thr  Ile Ala Glu 
        995                 1000                 1005             


Glu Pro  Ala Pro Gly Pro Gly  Pro Pro Pro Pro Ala  Ala Val Pro 
    1010                 1015                 1020             


Thr Ser  Ser Ser Gln Gly Arg  Pro Pro Tyr Pro Thr  Gly Pro Gly 
    1025                 1030                 1035             


Ala Asn  Val Ala Ser Pro Leu  Glu Asp Thr Glu Glu  Pro Arg Asp 
    1040                 1045                 1050             


Ser Arg  Pro Arg Pro Cys Asn  Gly Glu Gly Ala Gly  Gly Ala Tyr 
    1055                 1060                 1065             


Glu Arg  Ala Pro Gly Ser Gln  Thr Asp Gly Arg Ser  Gln Pro Arg 
    1070                 1075                 1080             


Thr Leu  Gly His Leu Pro Val  Ile Arg Arg Val Lys  Ser Glu Gly 
    1085                 1090                 1095             


Gln Val  Pro Thr Glu Pro Leu  Gly Gly Trp Arg Pro  Leu Ala Ala 
    1100                 1105                 1110             


Pro Phe  Pro Ala Pro Ala Val  Tyr Ser Asp Ala Thr  Gly Ser Asp 
    1115                 1120                 1125             


Pro Leu  Trp Gln Arg Leu Glu  Pro Cys Gly His Arg  Asp Ser Val 
    1130                 1135                 1140             


Ser Ser  Ser Ser Ser Met Ser  Ser Ser Asp Thr Val  Ile Asp Leu 
    1145                 1150                 1155             


Ser Leu  Pro Ser Leu Gly Leu  Gly Arg Ser Arg Glu  Asn Leu Ala 
    1160                 1165                 1170             


Gly Ala  His Met Gly Arg Leu  Pro Pro Arg Pro His  Ser Ala Ser 
    1175                 1180                 1185             


Ala Ala  Arg Pro Asp Leu Pro  Pro Val Thr Lys Ser  Lys Ser Asn 
    1190                 1195                 1200             


Pro Asn  Leu Arg Ala Thr Gly  Gln Arg Pro Pro Ile  Pro Asp Glu 
    1205                 1210                 1215             


Leu Gln  Pro Arg Ser Leu Ala  Pro Arg Met Ala Gly  Leu Pro Phe 
    1220                 1225                 1230             


Arg Pro  Pro Trp Gly Cys Leu  Ser Leu Val Gly Val  Gln Asp Cys 
    1235                 1240                 1245             


Pro Val  Ala Ala Lys Ser Lys  Ser Leu Gly Asp Leu  Thr Ala Asp 
    1250                 1255                 1260             


Asp Phe  Ala Pro Ser Phe Glu  Gly Gly Ser Arg Arg  Leu Ser His 
    1265                 1270                 1275             


Ser Leu  Gly Leu Pro Gly Gly  Thr Arg Arg Val Ser  Gly Pro Gly 
    1280                 1285                 1290             


Val Arg  Arg Asp Thr Leu Thr  Glu Gln Leu Arg Trp  Leu Thr Val 
    1295                 1300                 1305             


Phe Gln  Gln Ala Gly Asp Ile  Thr Ser Pro Thr Ser  Leu Gly Pro 
    1310                 1315                 1320             


Ala Gly  Glu Gly Val Ala Gly  Gly Pro Gly Phe Val  Arg Arg Ser 
    1325                 1330                 1335             


Ser Ser  Arg Ser His Ser Arg  Val Arg Ala Ile Ala  Ser Arg Ala 
    1340                 1345                 1350             


Arg Gln  Ala Gln Glu Arg Gln  Gln Arg Leu Gln Gly  Leu Gly Arg 
    1355                 1360                 1365             


Gln Gly  Pro Pro Glu Glu Glu  Arg Gly Thr Pro Glu  Gly Ala Cys 
    1370                 1375                 1380             


Ser Val  Gly His Glu Gly Ser  Val Asp Ala Pro Ala  Pro Ser Lys 
    1385                 1390                 1395             


Gly Ala  Leu Gly Pro Ala Ser  Ala Ala Ala Glu Asn  Leu Val Leu 
    1400                 1405                 1410             


Leu Arg  Leu 
    1415     


<210>  137
<211>  2931
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (635)..(2407)

<400>  137
actctatgtc tcctctcgtt ggattgtgac accgggaggt cagggaactc caggaccttg       60

ttctctgctg gattcgcagc aaccagcaca gcacgtaggg cgtagttggt gctggatgga      120

tgtttgttga atgaatgaat gatgaatggc tggcaccttg tctgctcatc cctaactcct      180

gttccttcat ctgtgcagcc ctaatctttg tttcctcatc tgtccatccc tttatttgtg      240

catcctcatt cttagcccct tcactgccct tctccatctc ttcctccttg ttcatttgtc      300

cctgttctct gtcctctact ccactcatgc ccatctctgt ccccttgact tacccagtcc      360

ctgctactat ctccatccct aatttctgcc ctcttgtctg tctactccta attccttttc      420

cttgtccatc cctaatacct gtcaccttgt ccttcttcct cgaatctcca tccctaatcc      480

atctgcccct aatctctgtc ccctttgccc atccttcctt ttctcggtgt ctctttccac      540

ccttatctcc acacctgccc accctgcact cccattctgt ttcccatctg cacccttgcc      600

ccatccctcc cacacacagg accagacggc cacc atg tca gga gac tac gag gat      655
                                      Met Ser Gly Asp Tyr Glu Asp         
                                      1               5                   

gac ctc tgc cgg cgg gca ctc atc ctg gtc tcg gac ctc tgt gcg cgg        703
Asp Leu Cys Arg Arg Ala Leu Ile Leu Val Ser Asp Leu Cys Ala Arg           
        10                  15                  20                        

gtc cga gat gct gac acc aac gac agg tgc cag gag ttc aat gac cga        751
Val Arg Asp Ala Asp Thr Asn Asp Arg Cys Gln Glu Phe Asn Asp Arg           
    25                  30                  35                            

atc cga ggc tat ccc cgg ggt cca gat gca gac atc tcc gtg agc ctg        799
Ile Arg Gly Tyr Pro Arg Gly Pro Asp Ala Asp Ile Ser Val Ser Leu           
40                  45                  50                  55            

ctg tcg gtc atc gtg aca ttc tgt ggc att gtc ctt ctg ggt gtc tct        847
Leu Ser Val Ile Val Thr Phe Cys Gly Ile Val Leu Leu Gly Val Ser           
                60                  65                  70                

ctc ttc gtg tcc tgg aag ttg tgc tgg gtg ccc tgg cgg gac aag gga        895
Leu Phe Val Ser Trp Lys Leu Cys Trp Val Pro Trp Arg Asp Lys Gly           
            75                  80                  85                    

ggc tcg gca gtg ggc ggt ggc ccc ctg cgc aaa gac cta ggc cct ggt        943
Gly Ser Ala Val Gly Gly Gly Pro Leu Arg Lys Asp Leu Gly Pro Gly           
        90                  95                  100                       

gtc ggg ctg gca ggc ctg gta ggc gga ggc ggg cac cac ctg gcg gct        991
Val Gly Leu Ala Gly Leu Val Gly Gly Gly Gly His His Leu Ala Ala           
    105                 110                 115                           

ggc ctg ggt ggc cat cct ctg ctg ggc ggc cca cac cac cat gcc cat       1039
Gly Leu Gly Gly His Pro Leu Leu Gly Gly Pro His His His Ala His           
120                 125                 130                 135           

gcc gcc cac cat cca ccc ttt gct gag ctg ctg gag cca ggc agc ctg       1087
Ala Ala His His Pro Pro Phe Ala Glu Leu Leu Glu Pro Gly Ser Leu           
                140                 145                 150               

ggg ggt tct gac acc cct gag ccc tcc tac ttg gac atg gac tcg tat       1135
Gly Gly Ser Asp Thr Pro Glu Pro Ser Tyr Leu Asp Met Asp Ser Tyr           
            155                 160                 165                   

cca gag gct gca gca gca gca gtg gcc gct ggg gtc aaa ccg agc caa       1183
Pro Glu Ala Ala Ala Ala Ala Val Ala Ala Gly Val Lys Pro Ser Gln           
        170                 175                 180                       

aca tcc cct gag ctg ccc tct gag ggg gga gca ggc tct ggg ttg ctc       1231
Thr Ser Pro Glu Leu Pro Ser Glu Gly Gly Ala Gly Ser Gly Leu Leu           
    185                 190                 195                           

ctg ctg ccc ccc agt ggt ggg ggc ttg ccc agt gcc cag tca cat cag       1279
Leu Leu Pro Pro Ser Gly Gly Gly Leu Pro Ser Ala Gln Ser His Gln           
200                 205                 210                 215           

cag gtc aca agc ctg gca ccc act acc agg tac cca gcc ctg ccc cga       1327
Gln Val Thr Ser Leu Ala Pro Thr Thr Arg Tyr Pro Ala Leu Pro Arg           
                220                 225                 230               

ccc ctc acc cag cag act ctg acc tcc cag ccg gac ccc agc agt gag       1375
Pro Leu Thr Gln Gln Thr Leu Thr Ser Gln Pro Asp Pro Ser Ser Glu           
            235                 240                 245                   

gag cgc cca cct gcc ctg ccc tta ccc ctg cct gga ggc gag gaa aaa       1423
Glu Arg Pro Pro Ala Leu Pro Leu Pro Leu Pro Gly Gly Glu Glu Lys           
        250                 255                 260                       

gcc aaa ctc att ggg cag att aag cca gag ctg tac cag ggg act ggc       1471
Ala Lys Leu Ile Gly Gln Ile Lys Pro Glu Leu Tyr Gln Gly Thr Gly           
    265                 270                 275                           

cct ggt ggc cgg cgg agc ggt ggg ggc cca ggc tct gga gag gca ggc       1519
Pro Gly Gly Arg Arg Ser Gly Gly Gly Pro Gly Ser Gly Glu Ala Gly           
280                 285                 290                 295           

aca ggg gca ccc tgt ggc cgt atc agc ttc gcc ctg cgg tac ctc tat       1567
Thr Gly Ala Pro Cys Gly Arg Ile Ser Phe Ala Leu Arg Tyr Leu Tyr           
                300                 305                 310               

ggc tcg gac cag ctg gtg gtg agg atc ctg cag gcc ctg gac ctc cct       1615
Gly Ser Asp Gln Leu Val Val Arg Ile Leu Gln Ala Leu Asp Leu Pro           
            315                 320                 325                   

gcc aag gac tcc aac ggc ttc tca gac ccc tac gtc aag atc tac ctg       1663
Ala Lys Asp Ser Asn Gly Phe Ser Asp Pro Tyr Val Lys Ile Tyr Leu           
        330                 335                 340                       

ctg cct gac cgc aag aaa aag ttt cag acc aag gtg cac agg aag acc       1711
Leu Pro Asp Arg Lys Lys Lys Phe Gln Thr Lys Val His Arg Lys Thr           
    345                 350                 355                           

ctg aac ccc gtc ttc aat gag acg ttt caa ttc tcg gtg ccc ctg gcc       1759
Leu Asn Pro Val Phe Asn Glu Thr Phe Gln Phe Ser Val Pro Leu Ala           
360                 365                 370                 375           

gag ctg gcc caa cgc aaa ctg cac ttc agc gtc tat gac ttt gac cgc       1807
Glu Leu Ala Gln Arg Lys Leu His Phe Ser Val Tyr Asp Phe Asp Arg           
                380                 385                 390               

ttc tcg cgg cac gac ctc atc ggc cag gtg gtg ctg gac aac ctc ctg       1855
Phe Ser Arg His Asp Leu Ile Gly Gln Val Val Leu Asp Asn Leu Leu           
            395                 400                 405                   

gag ctg gcc gag cag ccc cct gac cgc ccg ctc tgg agg gac atc gtg       1903
Glu Leu Ala Glu Gln Pro Pro Asp Arg Pro Leu Trp Arg Asp Ile Val           
        410                 415                 420                       

gag ggc ggc tcg gaa aaa gca gat ctt ggg gag ctc aac ttc tca ctc       1951
Glu Gly Gly Ser Glu Lys Ala Asp Leu Gly Glu Leu Asn Phe Ser Leu           
    425                 430                 435                           

tgc tac ctc ccc acg gcc ggg cgc ctc acc gtg acc atc atc aaa gcc       1999
Cys Tyr Leu Pro Thr Ala Gly Arg Leu Thr Val Thr Ile Ile Lys Ala           
440                 445                 450                 455           

tct aac ctc aaa gcg atg gac ctc act ggc ttc tca gac ccc tac gtg       2047
Ser Asn Leu Lys Ala Met Asp Leu Thr Gly Phe Ser Asp Pro Tyr Val           
                460                 465                 470               

aag gcc tcc ctg atc agc gag ggg cgg cgt ctg aag aag cgg aaa acc       2095
Lys Ala Ser Leu Ile Ser Glu Gly Arg Arg Leu Lys Lys Arg Lys Thr           
            475                 480                 485                   

tcc atc aag aag aac acg ctg aac ccc acc tat aat gag gcg ctg gtg       2143
Ser Ile Lys Lys Asn Thr Leu Asn Pro Thr Tyr Asn Glu Ala Leu Val           
        490                 495                 500                       

ttc gac gtg gcc ccc gag agc gtg gag aac gtg ggg ctc agc atc gcc       2191
Phe Asp Val Ala Pro Glu Ser Val Glu Asn Val Gly Leu Ser Ile Ala           
    505                 510                 515                           

gtg gtg gac tac gac tgc atc ggg cac aac gag gtg atc ggc gtg tgc       2239
Val Val Asp Tyr Asp Cys Ile Gly His Asn Glu Val Ile Gly Val Cys           
520                 525                 530                 535           

cgt gtg ggc ccc gac gct gcc gac ccg cac ggc cgc gag cac tgg gca       2287
Arg Val Gly Pro Asp Ala Ala Asp Pro His Gly Arg Glu His Trp Ala           
                540                 545                 550               

gag atg ctg gcc aat ccc cgc aag ccc gtg gag cac tgg cat cag cta       2335
Glu Met Leu Ala Asn Pro Arg Lys Pro Val Glu His Trp His Gln Leu           
            555                 560                 565                   

gtg gag gaa aag act gtg acc agc ttc aca aaa ggc agc aaa gga cta       2383
Val Glu Glu Lys Thr Val Thr Ser Phe Thr Lys Gly Ser Lys Gly Leu           
        570                 575                 580                       

tca gag aaa gag aac tcc gag tga ggggtctggc ctaggcccgg gatcggacca      2437
Ser Glu Lys Glu Asn Ser Glu                                               
    585                 590                                               

ggctccctca ggaccccatc ctttcctgcc cggaccgtga attcatctcc ttgaagccat     2497

aacgtccgag ctgctggtgc ggggcagccc tggccctagg cttcctaacc ctggaagcga     2557

gaggatgaga ggaggccggc ccagctcctt ctttcagggt gggggtcatt cagcctccac     2617

tgtgtctgtc ttttcttccc tggggctccc cctcgaggcg aggggccatg catgtctggg     2677

ggacccctgc cccccaaaac cctctgtctg tctctgtctc tttgctgttt gtccaagact     2737

cagtgtcccg acccttgttc tcgccgtgaa tgtcaatggg ccaatcctct ctgtcctttc     2797

agacacacac acacctgtgt ccaccccttc tgttcgccac accctgcgtc tggccggtcc     2857

ccccactgct gctgctatca acgccagaat aaacacactc tgtgggtctc actccaaaaa     2917

aaaaaaaaaa aaaa                                                       2931


<210>  138
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Ser Gly Asp Tyr Glu Asp Asp Leu Cys Arg Arg Ala Leu Ile Leu 
1               5                   10                  15      


Val Ser Asp Leu Cys Ala Arg Val Arg Asp Ala Asp Thr Asn Asp Arg 
            20                  25                  30          


Cys Gln Glu Phe Asn Asp Arg Ile Arg Gly Tyr Pro Arg Gly Pro Asp 
        35                  40                  45              


Ala Asp Ile Ser Val Ser Leu Leu Ser Val Ile Val Thr Phe Cys Gly 
    50                  55                  60                  


Ile Val Leu Leu Gly Val Ser Leu Phe Val Ser Trp Lys Leu Cys Trp 
65                  70                  75                  80  


Val Pro Trp Arg Asp Lys Gly Gly Ser Ala Val Gly Gly Gly Pro Leu 
                85                  90                  95      


Arg Lys Asp Leu Gly Pro Gly Val Gly Leu Ala Gly Leu Val Gly Gly 
            100                 105                 110         


Gly Gly His His Leu Ala Ala Gly Leu Gly Gly His Pro Leu Leu Gly 
        115                 120                 125             


Gly Pro His His His Ala His Ala Ala His His Pro Pro Phe Ala Glu 
    130                 135                 140                 


Leu Leu Glu Pro Gly Ser Leu Gly Gly Ser Asp Thr Pro Glu Pro Ser 
145                 150                 155                 160 


Tyr Leu Asp Met Asp Ser Tyr Pro Glu Ala Ala Ala Ala Ala Val Ala 
                165                 170                 175     


Ala Gly Val Lys Pro Ser Gln Thr Ser Pro Glu Leu Pro Ser Glu Gly 
            180                 185                 190         


Gly Ala Gly Ser Gly Leu Leu Leu Leu Pro Pro Ser Gly Gly Gly Leu 
        195                 200                 205             


Pro Ser Ala Gln Ser His Gln Gln Val Thr Ser Leu Ala Pro Thr Thr 
    210                 215                 220                 


Arg Tyr Pro Ala Leu Pro Arg Pro Leu Thr Gln Gln Thr Leu Thr Ser 
225                 230                 235                 240 


Gln Pro Asp Pro Ser Ser Glu Glu Arg Pro Pro Ala Leu Pro Leu Pro 
                245                 250                 255     


Leu Pro Gly Gly Glu Glu Lys Ala Lys Leu Ile Gly Gln Ile Lys Pro 
            260                 265                 270         


Glu Leu Tyr Gln Gly Thr Gly Pro Gly Gly Arg Arg Ser Gly Gly Gly 
        275                 280                 285             


Pro Gly Ser Gly Glu Ala Gly Thr Gly Ala Pro Cys Gly Arg Ile Ser 
    290                 295                 300                 


Phe Ala Leu Arg Tyr Leu Tyr Gly Ser Asp Gln Leu Val Val Arg Ile 
305                 310                 315                 320 


Leu Gln Ala Leu Asp Leu Pro Ala Lys Asp Ser Asn Gly Phe Ser Asp 
                325                 330                 335     


Pro Tyr Val Lys Ile Tyr Leu Leu Pro Asp Arg Lys Lys Lys Phe Gln 
            340                 345                 350         


Thr Lys Val His Arg Lys Thr Leu Asn Pro Val Phe Asn Glu Thr Phe 
        355                 360                 365             


Gln Phe Ser Val Pro Leu Ala Glu Leu Ala Gln Arg Lys Leu His Phe 
    370                 375                 380                 


Ser Val Tyr Asp Phe Asp Arg Phe Ser Arg His Asp Leu Ile Gly Gln 
385                 390                 395                 400 


Val Val Leu Asp Asn Leu Leu Glu Leu Ala Glu Gln Pro Pro Asp Arg 
                405                 410                 415     


Pro Leu Trp Arg Asp Ile Val Glu Gly Gly Ser Glu Lys Ala Asp Leu 
            420                 425                 430         


Gly Glu Leu Asn Phe Ser Leu Cys Tyr Leu Pro Thr Ala Gly Arg Leu 
        435                 440                 445             


Thr Val Thr Ile Ile Lys Ala Ser Asn Leu Lys Ala Met Asp Leu Thr 
    450                 455                 460                 


Gly Phe Ser Asp Pro Tyr Val Lys Ala Ser Leu Ile Ser Glu Gly Arg 
465                 470                 475                 480 


Arg Leu Lys Lys Arg Lys Thr Ser Ile Lys Lys Asn Thr Leu Asn Pro 
                485                 490                 495     


Thr Tyr Asn Glu Ala Leu Val Phe Asp Val Ala Pro Glu Ser Val Glu 
            500                 505                 510         


Asn Val Gly Leu Ser Ile Ala Val Val Asp Tyr Asp Cys Ile Gly His 
        515                 520                 525             


Asn Glu Val Ile Gly Val Cys Arg Val Gly Pro Asp Ala Ala Asp Pro 
    530                 535                 540                 


His Gly Arg Glu His Trp Ala Glu Met Leu Ala Asn Pro Arg Lys Pro 
545                 550                 555                 560 


Val Glu His Trp His Gln Leu Val Glu Glu Lys Thr Val Thr Ser Phe 
                565                 570                 575     


Thr Lys Gly Ser Lys Gly Leu Ser Glu Lys Glu Asn Ser Glu 
            580                 585                 590 


<210>  139
<211>  4744
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (72)..(3059)

<400>  139
aatcagctca gcgaagccgc cgcagaggct gatggggggc tggaggctgt gaggcttcca       60

gcgtcggtac c atg gcg acg cgc ggt ggg gct ggg gtg gca atg gcg gtt       110
             Met Ala Thr Arg Gly Gly Ala Gly Val Ala Met Ala Val          
             1               5                   10                       

tgg tcc ctc tta tcc gcc cgg gcc gtg acc gcg ttc ctt ctg ttg ttc        158
Trp Ser Leu Leu Ser Ala Arg Ala Val Thr Ala Phe Leu Leu Leu Phe           
    15                  20                  25                            

ctc cct cgc ttc tta cag gcc cag acc ttc tct ttc cct ttc cag cag        206
Leu Pro Arg Phe Leu Gln Ala Gln Thr Phe Ser Phe Pro Phe Gln Gln           
30                  35                  40                  45            

ccg gag aag tgc gac aac aac cag tac ttt gat atc tcc gcc ctc tcg        254
Pro Glu Lys Cys Asp Asn Asn Gln Tyr Phe Asp Ile Ser Ala Leu Ser           
                50                  55                  60                

tgt gtt cct tgt gga gct aac cag agg caa gat gcc cga gga act tca        302
Cys Val Pro Cys Gly Ala Asn Gln Arg Gln Asp Ala Arg Gly Thr Ser           
            65                  70                  75                    

tgt gta tgt cta cca gga ttt cag atg atc tct aat aat gga gga cct        350
Cys Val Cys Leu Pro Gly Phe Gln Met Ile Ser Asn Asn Gly Gly Pro           
        80                  85                  90                        

gct att att tgt aaa aag tgc cca gaa aac atg aaa ggt gtt aca gaa        398
Ala Ile Ile Cys Lys Lys Cys Pro Glu Asn Met Lys Gly Val Thr Glu           
    95                  100                 105                           

gat ggc tgg aac tgc att tct tgc cct agt gac tta act gcc gaa gga        446
Asp Gly Trp Asn Cys Ile Ser Cys Pro Ser Asp Leu Thr Ala Glu Gly           
110                 115                 120                 125           

aaa tgt cac tgt ccc att ggc cat att tta gtg gaa aga gac att aat        494
Lys Cys His Cys Pro Ile Gly His Ile Leu Val Glu Arg Asp Ile Asn           
                130                 135                 140               

gga aca ttg ttg tct caa gca act tgt gag ctc tgt gat gga aat gaa        542
Gly Thr Leu Leu Ser Gln Ala Thr Cys Glu Leu Cys Asp Gly Asn Glu           
            145                 150                 155                   

aac tct ttt atg gta gta aat gct tta gga gac agg tgc gtc cga tgt        590
Asn Ser Phe Met Val Val Asn Ala Leu Gly Asp Arg Cys Val Arg Cys           
        160                 165                 170                       

gag cca aca ttt gtt aat acc agc agg tcc tgt gca tgt tca gaa cct        638
Glu Pro Thr Phe Val Asn Thr Ser Arg Ser Cys Ala Cys Ser Glu Pro           
    175                 180                 185                           

aac att tta aca ggg gga tta tgt ttc agc agc aca ggg aat ttt cct        686
Asn Ile Leu Thr Gly Gly Leu Cys Phe Ser Ser Thr Gly Asn Phe Pro           
190                 195                 200                 205           

cta cgt aga att tca gct gca cgt tat gga gaa gtt ggc atg tct tta        734
Leu Arg Arg Ile Ser Ala Ala Arg Tyr Gly Glu Val Gly Met Ser Leu           
                210                 215                 220               

act tca gaa tgg ttt gca aag tat ttg caa tca tca gca gct gca tgt        782
Thr Ser Glu Trp Phe Ala Lys Tyr Leu Gln Ser Ser Ala Ala Ala Cys           
            225                 230                 235                   

tgg gta tat gcc aat cta aca tct tgt caa gct ctt gga aat atg tgt        830
Trp Val Tyr Ala Asn Leu Thr Ser Cys Gln Ala Leu Gly Asn Met Cys           
        240                 245                 250                       

gtg atg aac atg aat tct tac gac ttt gcc aca ttt gat gca tgt gga        878
Val Met Asn Met Asn Ser Tyr Asp Phe Ala Thr Phe Asp Ala Cys Gly           
    255                 260                 265                           

cta ttt cag ttt atc ttt gaa aat act gct gga ctg agc act gtt cat        926
Leu Phe Gln Phe Ile Phe Glu Asn Thr Ala Gly Leu Ser Thr Val His           
270                 275                 280                 285           

tct att tca ttt tgg aga cag aat ctt cct tgg ctg ttt tat gga gac        974
Ser Ile Ser Phe Trp Arg Gln Asn Leu Pro Trp Leu Phe Tyr Gly Asp           
                290                 295                 300               

cag tta gga tta gca cct caa gtg ctc agt tct acc tct ctt cct aca       1022
Gln Leu Gly Leu Ala Pro Gln Val Leu Ser Ser Thr Ser Leu Pro Thr           
            305                 310                 315                   

aat ttc agt ttt aaa gga gaa aac cag aat aca aaa ctg aag ttt gtt       1070
Asn Phe Ser Phe Lys Gly Glu Asn Gln Asn Thr Lys Leu Lys Phe Val           
        320                 325                 330                       

gct gct tcc tat gat ata aga gga aat ttt ctc aag tgg caa act tta       1118
Ala Ala Ser Tyr Asp Ile Arg Gly Asn Phe Leu Lys Trp Gln Thr Leu           
    335                 340                 345                           

gaa gga ggt gtt tta cag ctt tgt cca gac aca gag aca agg cta aat       1166
Glu Gly Gly Val Leu Gln Leu Cys Pro Asp Thr Glu Thr Arg Leu Asn           
350                 355                 360                 365           

gct gct tat tca ttt gga aca acc tac caa caa aat tgt gag att cct       1214
Ala Ala Tyr Ser Phe Gly Thr Thr Tyr Gln Gln Asn Cys Glu Ile Pro           
                370                 375                 380               

atc tct aag atc tta att gac ttt ccc act cct ata ttt tat gat gtg       1262
Ile Ser Lys Ile Leu Ile Asp Phe Pro Thr Pro Ile Phe Tyr Asp Val           
            385                 390                 395                   

tac ctt gaa tat act gat gaa aat caa cat caa tat att ttg gct gtg       1310
Tyr Leu Glu Tyr Thr Asp Glu Asn Gln His Gln Tyr Ile Leu Ala Val           
        400                 405                 410                       

cct gtg tta aac cta aat ctt caa cat aat aag ata ttt gtg aac caa       1358
Pro Val Leu Asn Leu Asn Leu Gln His Asn Lys Ile Phe Val Asn Gln           
    415                 420                 425                           

gac agc aac tct gga aag tgg ctt cta act cgg cgc att ttc tta gtg       1406
Asp Ser Asn Ser Gly Lys Trp Leu Leu Thr Arg Arg Ile Phe Leu Val           
430                 435                 440                 445           

gat gca gta agt gga cga gaa aat gac tta gga act cag cca aga gta       1454
Asp Ala Val Ser Gly Arg Glu Asn Asp Leu Gly Thr Gln Pro Arg Val           
                450                 455                 460               

att cga gtt gct act caa ata tca ctg agt gtc cac ctt gta ccc aac       1502
Ile Arg Val Ala Thr Gln Ile Ser Leu Ser Val His Leu Val Pro Asn           
            465                 470                 475                   

aca ata aat gga aac atc tac cct ccc tta atc acc att gcc tac agt       1550
Thr Ile Asn Gly Asn Ile Tyr Pro Pro Leu Ile Thr Ile Ala Tyr Ser           
        480                 485                 490                       

gac att gat atc aaa gat gcc aac agc cag tct gtg aag gtt tct ttc       1598
Asp Ile Asp Ile Lys Asp Ala Asn Ser Gln Ser Val Lys Val Ser Phe           
    495                 500                 505                           

tca gtc aca tat gaa atg gat cat gga gaa gca cat gtc cag aca gat       1646
Ser Val Thr Tyr Glu Met Asp His Gly Glu Ala His Val Gln Thr Asp           
510                 515                 520                 525           

att gct ttg ggt gta ttg ggt ggg cta gct gtt tta gca tct ctt ttg       1694
Ile Ala Leu Gly Val Leu Gly Gly Leu Ala Val Leu Ala Ser Leu Leu           
                530                 535                 540               

aag aca gca gga tgg aag agg cgc att ggg agt ccc atg att gat tta       1742
Lys Thr Ala Gly Trp Lys Arg Arg Ile Gly Ser Pro Met Ile Asp Leu           
            545                 550                 555                   

cag aca gtt gtg aaa ttc ttg gtg tac tat gct ggt gat ctg gcc aat       1790
Gln Thr Val Val Lys Phe Leu Val Tyr Tyr Ala Gly Asp Leu Ala Asn           
        560                 565                 570                       

gtt ttc ttt atc atc aca gtg gga aca ggt ctt tac tgg ctt att ttc       1838
Val Phe Phe Ile Ile Thr Val Gly Thr Gly Leu Tyr Trp Leu Ile Phe           
    575                 580                 585                           

ttc aaa gca cag aag tct gtg tct gtt ttg ctg cca atg cca att cag       1886
Phe Lys Ala Gln Lys Ser Val Ser Val Leu Leu Pro Met Pro Ile Gln           
590                 595                 600                 605           

gaa gaa cgt ttt gtc act tat gtt gga tgt gcc ttt gct ctg aag gca       1934
Glu Glu Arg Phe Val Thr Tyr Val Gly Cys Ala Phe Ala Leu Lys Ala           
                610                 615                 620               

cta caa ttt ttg cat aag ctc ata tcc cag att aca ata gat gta ttc       1982
Leu Gln Phe Leu His Lys Leu Ile Ser Gln Ile Thr Ile Asp Val Phe           
            625                 630                 635                   

ttt att gat tgg gag cga cct aaa gga aag gtt ctt aaa gct gtt gaa       2030
Phe Ile Asp Trp Glu Arg Pro Lys Gly Lys Val Leu Lys Ala Val Glu           
        640                 645                 650                       

ggt gag ggt ggt gta cga agt gcc act gtt cct gta agc ata tgg aga       2078
Gly Glu Gly Gly Val Arg Ser Ala Thr Val Pro Val Ser Ile Trp Arg           
    655                 660                 665                           

aca tat ttt gta gca aat gaa tgg aat gaa att cag act gtg aga aaa       2126
Thr Tyr Phe Val Ala Asn Glu Trp Asn Glu Ile Gln Thr Val Arg Lys           
670                 675                 680                 685           

att aat tca ctc ttt caa gta ctt act gtc ctc ttc ttt ttg gag gtt       2174
Ile Asn Ser Leu Phe Gln Val Leu Thr Val Leu Phe Phe Leu Glu Val           
                690                 695                 700               

gtg gga ttc aag aac tta gca tta atg gac tca tct tct agt ctt tct       2222
Val Gly Phe Lys Asn Leu Ala Leu Met Asp Ser Ser Ser Ser Leu Ser           
            705                 710                 715                   

aga aac cca cct agc tac ata gct cct tat agc tgc att ttg aga tat       2270
Arg Asn Pro Pro Ser Tyr Ile Ala Pro Tyr Ser Cys Ile Leu Arg Tyr           
        720                 725                 730                       

gca gtg tct gct gct ctt tgg cta gcc att gga att ata cag gtc gtg       2318
Ala Val Ser Ala Ala Leu Trp Leu Ala Ile Gly Ile Ile Gln Val Val           
    735                 740                 745                           

ttc ttt gct gtc ttt tat gag aga ttt ata gaa gat aaa att cga cag       2366
Phe Phe Ala Val Phe Tyr Glu Arg Phe Ile Glu Asp Lys Ile Arg Gln           
750                 755                 760                 765           

ttc gtt gat tta tgc tct atg agt aat ata tca gtg ttt ctg tta tcc       2414
Phe Val Asp Leu Cys Ser Met Ser Asn Ile Ser Val Phe Leu Leu Ser           
                770                 775                 780               

cac aaa tgt ttt gga tat tac att cat ggt aga tca gta cat ggg cat       2462
His Lys Cys Phe Gly Tyr Tyr Ile His Gly Arg Ser Val His Gly His           
            785                 790                 795                   

gca gat act aat atg gaa gaa atg aat atg aac ctt aaa aga gaa gcg       2510
Ala Asp Thr Asn Met Glu Glu Met Asn Met Asn Leu Lys Arg Glu Ala           
        800                 805                 810                       

gaa aat ttg tgt agc cag aga ggt ttg gta ccc aac aca gat ggt cag       2558
Glu Asn Leu Cys Ser Gln Arg Gly Leu Val Pro Asn Thr Asp Gly Gln           
    815                 820                 825                           

act ttt gag att gca att tct aac cag atg aga caa cat tat gac aga       2606
Thr Phe Glu Ile Ala Ile Ser Asn Gln Met Arg Gln His Tyr Asp Arg           
830                 835                 840                 845           

att cat gag aca cta ata agg aaa aat ggt cct gct aga cta ctg agt       2654
Ile His Glu Thr Leu Ile Arg Lys Asn Gly Pro Ala Arg Leu Leu Ser           
                850                 855                 860               

tca tca gca agt act ttt gag cag agt ata aaa gca tat cat atg atg       2702
Ser Ser Ala Ser Thr Phe Glu Gln Ser Ile Lys Ala Tyr His Met Met           
            865                 870                 875                   

aat aaa ttt ctt ggc tcc ttc att gac cat gtt cat aag gaa atg gat       2750
Asn Lys Phe Leu Gly Ser Phe Ile Asp His Val His Lys Glu Met Asp           
        880                 885                 890                       

tac ttt ata aaa gat aag ttg ctt ctt gaa aga att ctt gga atg gaa       2798
Tyr Phe Ile Lys Asp Lys Leu Leu Leu Glu Arg Ile Leu Gly Met Glu           
    895                 900                 905                           

ttc atg gaa cca atg gaa aaa agc atc ttt tac aat gat gaa ggt tat       2846
Phe Met Glu Pro Met Glu Lys Ser Ile Phe Tyr Asn Asp Glu Gly Tyr           
910                 915                 920                 925           

tct ttc agc agt gtc ctg tat tat gga aat gaa gct act ctt ctt att       2894
Ser Phe Ser Ser Val Leu Tyr Tyr Gly Asn Glu Ala Thr Leu Leu Ile           
                930                 935                 940               

ttt gat ctg ctg ttc ttc tgt gtt gtg gat ttg gct tgc caa aat ttt       2942
Phe Asp Leu Leu Phe Phe Cys Val Val Asp Leu Ala Cys Gln Asn Phe           
            945                 950                 955                   

att tta gca tcc ttc ctt aca tat cta caa caa gag att ttt aga tat       2990
Ile Leu Ala Ser Phe Leu Thr Tyr Leu Gln Gln Glu Ile Phe Arg Tyr           
        960                 965                 970                       

atc cgt aat aca gta gga caa aag aat ttg gca tcc aaa aca ttg gtg       3038
Ile Arg Asn Thr Val Gly Gln Lys Asn Leu Ala Ser Lys Thr Leu Val           
    975                 980                 985                           

gat caa aga ttt ttg att taa cttcctgaat aaataactta aagactcagt          3089
Asp Gln Arg Phe Leu Ile                                                   
990                 995                                                   

ataatcatgg ccaaaaaaaa gtcatgatat caggttagtt tgccatattt tttaaaactt     3149

ataatgcaga ctattctgtt tttgtttttt atttgcagaa agatttattt ttataacttg     3209

ggaatatata acctgatata atagaaaata ctgttttccc attgtgtgta gtatttaatg     3269

cagtaaataa taaattaata ctgacagtga ggccaaaaaa aatctaaatg ttgctttcag     3329

cataatactt tttaatgcta attaaaacag tccccatcat ttgtctctgt agattatttt     3389

ataaactgag agctgcctga atcttctcac attgacaaag taatttgatt ccaagtttaa     3449

gactagtttt cagtttgata ttttcatgtt ttgtgtgctt atggttaaat aaatgttgaa     3509

agatattttc aagtttactt agaaatttta aattgtatta ttgctgattc aatttgcatc     3569

attctaattg ctcatcctct ttggcagtgg attaattcac tgttgggtta atatgcatct     3629

catgaaatga tatcttttca ttcctttgta tacctgtatt aggtcagtat acgctttcca     3689

tgaaatatat ttgcatttct aatatagttt acatttatta agttataacg tatgacattt     3749

ttcccaatat cattttttat acattttaat tacttaatgt tttaagagtt ctcttccaga     3809

gttttgcttt tcaattacgt ttaaagactg taaataacaa acagtaaggc tgggcgctgt     3869

ggcttacgcc tgtaatccca gcactttgga aggccaaggc acgtggatca ctttaggtca     3929

ggagttcaag aacagcctgg ccaacatgga aaaccccatc tctacaaaaa atacaaaaat     3989

tagttggatg tggtggcctg taatcccagc tatttgggag gctgaggcat gagaatagct     4049

tgaaaccagg aggtggaggc tgtagtgagc cagatagcac cactgcactc cagccaggat     4109

gacagagcaa gaccctgtct cagaaaaaac aaaaacaaaa cactgtaaat gtatcatgtt     4169

tctcactgct ttctatgtta atgctgtgta aatacttaaa atggaatact gtataaatat     4229

tatttatatt ttctcagatg aaaatatata ctaaaacatt tggtatttct gttttctgtt     4289

tcattaatgt atatctgatg gagtaccatt taggaatata acattattgg ggcagaggtc     4349

ccagccattg ccaaagttga atcttttaca tttccctgaa tcttgaggat gactgaaaag     4409

gaagtctttg aaactgcagt ttctgaagga tcacagtaca ggaatgcctt tataaaagct     4469

gcagagataa atacatgtac ttatatggca tggatattta aaaccactca ctcagaagca     4529

tatgaaagaa attcaaccat cattcaacat agaagaagtt aattttagtg caaaagtttt     4589

taagtattaa atttcacaat aaaggatcaa ttggcttact tgctgataaa ttaaaacaga     4649

aaacatttaa aatcattcta aattttgtat gatattttta ttttggctag gtgcataaaa     4709

atgtgttcag attttcaaaa aaaaaaaaaa aaaaa                                4744


<210>  140
<211>  995
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Ala Thr Arg Gly Gly Ala Gly Val Ala Met Ala Val Trp Ser Leu 
1               5                   10                  15      


Leu Ser Ala Arg Ala Val Thr Ala Phe Leu Leu Leu Phe Leu Pro Arg 
            20                  25                  30          


Phe Leu Gln Ala Gln Thr Phe Ser Phe Pro Phe Gln Gln Pro Glu Lys 
        35                  40                  45              


Cys Asp Asn Asn Gln Tyr Phe Asp Ile Ser Ala Leu Ser Cys Val Pro 
    50                  55                  60                  


Cys Gly Ala Asn Gln Arg Gln Asp Ala Arg Gly Thr Ser Cys Val Cys 
65                  70                  75                  80  


Leu Pro Gly Phe Gln Met Ile Ser Asn Asn Gly Gly Pro Ala Ile Ile 
                85                  90                  95      


Cys Lys Lys Cys Pro Glu Asn Met Lys Gly Val Thr Glu Asp Gly Trp 
            100                 105                 110         


Asn Cys Ile Ser Cys Pro Ser Asp Leu Thr Ala Glu Gly Lys Cys His 
        115                 120                 125             


Cys Pro Ile Gly His Ile Leu Val Glu Arg Asp Ile Asn Gly Thr Leu 
    130                 135                 140                 


Leu Ser Gln Ala Thr Cys Glu Leu Cys Asp Gly Asn Glu Asn Ser Phe 
145                 150                 155                 160 


Met Val Val Asn Ala Leu Gly Asp Arg Cys Val Arg Cys Glu Pro Thr 
                165                 170                 175     


Phe Val Asn Thr Ser Arg Ser Cys Ala Cys Ser Glu Pro Asn Ile Leu 
            180                 185                 190         


Thr Gly Gly Leu Cys Phe Ser Ser Thr Gly Asn Phe Pro Leu Arg Arg 
        195                 200                 205             


Ile Ser Ala Ala Arg Tyr Gly Glu Val Gly Met Ser Leu Thr Ser Glu 
    210                 215                 220                 


Trp Phe Ala Lys Tyr Leu Gln Ser Ser Ala Ala Ala Cys Trp Val Tyr 
225                 230                 235                 240 


Ala Asn Leu Thr Ser Cys Gln Ala Leu Gly Asn Met Cys Val Met Asn 
                245                 250                 255     


Met Asn Ser Tyr Asp Phe Ala Thr Phe Asp Ala Cys Gly Leu Phe Gln 
            260                 265                 270         


Phe Ile Phe Glu Asn Thr Ala Gly Leu Ser Thr Val His Ser Ile Ser 
        275                 280                 285             


Phe Trp Arg Gln Asn Leu Pro Trp Leu Phe Tyr Gly Asp Gln Leu Gly 
    290                 295                 300                 


Leu Ala Pro Gln Val Leu Ser Ser Thr Ser Leu Pro Thr Asn Phe Ser 
305                 310                 315                 320 


Phe Lys Gly Glu Asn Gln Asn Thr Lys Leu Lys Phe Val Ala Ala Ser 
                325                 330                 335     


Tyr Asp Ile Arg Gly Asn Phe Leu Lys Trp Gln Thr Leu Glu Gly Gly 
            340                 345                 350         


Val Leu Gln Leu Cys Pro Asp Thr Glu Thr Arg Leu Asn Ala Ala Tyr 
        355                 360                 365             


Ser Phe Gly Thr Thr Tyr Gln Gln Asn Cys Glu Ile Pro Ile Ser Lys 
    370                 375                 380                 


Ile Leu Ile Asp Phe Pro Thr Pro Ile Phe Tyr Asp Val Tyr Leu Glu 
385                 390                 395                 400 


Tyr Thr Asp Glu Asn Gln His Gln Tyr Ile Leu Ala Val Pro Val Leu 
                405                 410                 415     


Asn Leu Asn Leu Gln His Asn Lys Ile Phe Val Asn Gln Asp Ser Asn 
            420                 425                 430         


Ser Gly Lys Trp Leu Leu Thr Arg Arg Ile Phe Leu Val Asp Ala Val 
        435                 440                 445             


Ser Gly Arg Glu Asn Asp Leu Gly Thr Gln Pro Arg Val Ile Arg Val 
    450                 455                 460                 


Ala Thr Gln Ile Ser Leu Ser Val His Leu Val Pro Asn Thr Ile Asn 
465                 470                 475                 480 


Gly Asn Ile Tyr Pro Pro Leu Ile Thr Ile Ala Tyr Ser Asp Ile Asp 
                485                 490                 495     


Ile Lys Asp Ala Asn Ser Gln Ser Val Lys Val Ser Phe Ser Val Thr 
            500                 505                 510         


Tyr Glu Met Asp His Gly Glu Ala His Val Gln Thr Asp Ile Ala Leu 
        515                 520                 525             


Gly Val Leu Gly Gly Leu Ala Val Leu Ala Ser Leu Leu Lys Thr Ala 
    530                 535                 540                 


Gly Trp Lys Arg Arg Ile Gly Ser Pro Met Ile Asp Leu Gln Thr Val 
545                 550                 555                 560 


Val Lys Phe Leu Val Tyr Tyr Ala Gly Asp Leu Ala Asn Val Phe Phe 
                565                 570                 575     


Ile Ile Thr Val Gly Thr Gly Leu Tyr Trp Leu Ile Phe Phe Lys Ala 
            580                 585                 590         


Gln Lys Ser Val Ser Val Leu Leu Pro Met Pro Ile Gln Glu Glu Arg 
        595                 600                 605             


Phe Val Thr Tyr Val Gly Cys Ala Phe Ala Leu Lys Ala Leu Gln Phe 
    610                 615                 620                 


Leu His Lys Leu Ile Ser Gln Ile Thr Ile Asp Val Phe Phe Ile Asp 
625                 630                 635                 640 


Trp Glu Arg Pro Lys Gly Lys Val Leu Lys Ala Val Glu Gly Glu Gly 
                645                 650                 655     


Gly Val Arg Ser Ala Thr Val Pro Val Ser Ile Trp Arg Thr Tyr Phe 
            660                 665                 670         


Val Ala Asn Glu Trp Asn Glu Ile Gln Thr Val Arg Lys Ile Asn Ser 
        675                 680                 685             


Leu Phe Gln Val Leu Thr Val Leu Phe Phe Leu Glu Val Val Gly Phe 
    690                 695                 700                 


Lys Asn Leu Ala Leu Met Asp Ser Ser Ser Ser Leu Ser Arg Asn Pro 
705                 710                 715                 720 


Pro Ser Tyr Ile Ala Pro Tyr Ser Cys Ile Leu Arg Tyr Ala Val Ser 
                725                 730                 735     


Ala Ala Leu Trp Leu Ala Ile Gly Ile Ile Gln Val Val Phe Phe Ala 
            740                 745                 750         


Val Phe Tyr Glu Arg Phe Ile Glu Asp Lys Ile Arg Gln Phe Val Asp 
        755                 760                 765             


Leu Cys Ser Met Ser Asn Ile Ser Val Phe Leu Leu Ser His Lys Cys 
    770                 775                 780                 


Phe Gly Tyr Tyr Ile His Gly Arg Ser Val His Gly His Ala Asp Thr 
785                 790                 795                 800 


Asn Met Glu Glu Met Asn Met Asn Leu Lys Arg Glu Ala Glu Asn Leu 
                805                 810                 815     


Cys Ser Gln Arg Gly Leu Val Pro Asn Thr Asp Gly Gln Thr Phe Glu 
            820                 825                 830         


Ile Ala Ile Ser Asn Gln Met Arg Gln His Tyr Asp Arg Ile His Glu 
        835                 840                 845             


Thr Leu Ile Arg Lys Asn Gly Pro Ala Arg Leu Leu Ser Ser Ser Ala 
    850                 855                 860                 


Ser Thr Phe Glu Gln Ser Ile Lys Ala Tyr His Met Met Asn Lys Phe 
865                 870                 875                 880 


Leu Gly Ser Phe Ile Asp His Val His Lys Glu Met Asp Tyr Phe Ile 
                885                 890                 895     


Lys Asp Lys Leu Leu Leu Glu Arg Ile Leu Gly Met Glu Phe Met Glu 
            900                 905                 910         


Pro Met Glu Lys Ser Ile Phe Tyr Asn Asp Glu Gly Tyr Ser Phe Ser 
        915                 920                 925             


Ser Val Leu Tyr Tyr Gly Asn Glu Ala Thr Leu Leu Ile Phe Asp Leu 
    930                 935                 940                 


Leu Phe Phe Cys Val Val Asp Leu Ala Cys Gln Asn Phe Ile Leu Ala 
945                 950                 955                 960 


Ser Phe Leu Thr Tyr Leu Gln Gln Glu Ile Phe Arg Tyr Ile Arg Asn 
                965                 970                 975     


Thr Val Gly Gln Lys Asn Leu Ala Ser Lys Thr Leu Val Asp Gln Arg 
            980                 985                 990         


Phe Leu Ile 
        995 


<210>  141
<211>  1076
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (485)..(787)

<400>  141
cgcttgctga ctgagctgaa aagggactcc ccacagagca ggctcaccag tgtcccgaca       60

gccgggcaga tcacggggac ggggaattct gagcagaccc tcttcagaag ttgagtctca      120

aggggccttg gggaacttgg tcagcagatg gcaagacttc atctgtcagt gggcgggtca      180

gctcagcagg actcctgtct ttggaactga gactcaagtc tctactctgt accaagacag      240

agttggaggc taagaaacaa gacacacaac cattttccat cattgagggg caaggcaggg      300

cttggcatga ggcagaaccg ggctccatca atgccacatg tcaggaggaa ccccttttct      360

gtttcaatcc ctcctgccca tttgtgggag gcattagaga ggcctgacat agtttttttt      420

tctccacggc ctgaggacgt gataggattt cattcccgcc ccaccttgtt ggttggatgg      480

aatc atg cgc cca att gtg gtc aag acc aag aaa ctg aga aac gaa gca       529
     Met Arg Pro Ile Val Val Lys Thr Lys Lys Leu Arg Asn Glu Ala          
     1               5                   10                  15           

aat ccg tgg gat gca gag ggt acg ctg atg act tct gct ggg gag aga        577
Asn Pro Trp Asp Ala Glu Gly Thr Leu Met Thr Ser Ala Gly Glu Arg           
                20                  25                  30                

agc cca aac aca cgt cct ggg cag agc cca gag acc ggg agt gtg gct        625
Ser Pro Asn Thr Arg Pro Gly Gln Ser Pro Glu Thr Gly Ser Val Ala           
            35                  40                  45                    

gcc agt gag cac ccg gct gag gga caa gca ggt ggg cct cag tgg tgg        673
Ala Ser Glu His Pro Ala Glu Gly Gln Ala Gly Gly Pro Gln Trp Trp           
        50                  55                  60                        

ctg cca ggt ccc tgg acg ccg ggg gcc acc ggc ctt gcc tct cct ctg        721
Leu Pro Gly Pro Trp Thr Pro Gly Ala Thr Gly Leu Ala Ser Pro Leu           
    65                  70                  75                            

cct cgg aag cac cgg agg ctt tgg gga tct ggt ggt cct ctg gcc ctg        769
Pro Arg Lys His Arg Arg Leu Trp Gly Ser Gly Gly Pro Leu Ala Leu           
80                  85                  90                  95            

aac gtg gac ctg gtg tga caaagggaag tttgccatct ccatcctcct               817
Asn Val Asp Leu Val                                                       
                100                                                       

caagctgcct gtgcacccca gtagcaccca ccctctctgt gctcccgtct gcaccgcatg      877

tcctggggtc cttctttgta ctgcacccaa tgacaggaac cagtgccctg actgtgactt      937

gcttcccccc tcagggacac acaagcactt tcacatcgag gctacttttc accccttctg      997

cctcctgcag ggacgctgca tgcagaggca ggaggacaga ggggctggtc tcaggtgtgg     1057

cttctctcac acctggcgc                                                  1076


<210>  142
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Arg Pro Ile Val Val Lys Thr Lys Lys Leu Arg Asn Glu Ala Asn 
1               5                   10                  15      


Pro Trp Asp Ala Glu Gly Thr Leu Met Thr Ser Ala Gly Glu Arg Ser 
            20                  25                  30          


Pro Asn Thr Arg Pro Gly Gln Ser Pro Glu Thr Gly Ser Val Ala Ala 
        35                  40                  45              


Ser Glu His Pro Ala Glu Gly Gln Ala Gly Gly Pro Gln Trp Trp Leu 
    50                  55                  60                  


Pro Gly Pro Trp Thr Pro Gly Ala Thr Gly Leu Ala Ser Pro Leu Pro 
65                  70                  75                  80  


Arg Lys His Arg Arg Leu Trp Gly Ser Gly Gly Pro Leu Ala Leu Asn 
                85                  90                  95      


Val Asp Leu Val 
            100 


<210>  143
<211>  1038
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1038)

<400>  143
atg aat ttg gag ggc act tca ggt ggc ata ctt caa aaa gaa ttc tgg         48
Met Asn Leu Glu Gly Thr Ser Gly Gly Ile Leu Gln Lys Glu Phe Trp           
1               5                   10                  15                

aga aac aga att cag tat aac cag agt caa aag gat atc ctc caa tca         96
Arg Asn Arg Ile Gln Tyr Asn Gln Ser Gln Lys Asp Ile Leu Gln Ser           
            20                  25                  30                    

tgg ttt caa cat gac cct ttc cct gat aaa gct gcc aga gaa caa ctg        144
Trp Phe Gln His Asp Pro Phe Pro Asp Lys Ala Ala Arg Glu Gln Leu           
        35                  40                  45                        

gcc aaa gaa att ggg gtt cca gaa tct aat att cag gtt tgg ttt aaa        192
Ala Lys Glu Ile Gly Val Pro Glu Ser Asn Ile Gln Val Trp Phe Lys           
    50                  55                  60                            

aat tac aga gta aaa cag aga aaa ctg gat tat aag tgc ttc tca gaa        240
Asn Tyr Arg Val Lys Gln Arg Lys Leu Asp Tyr Lys Cys Phe Ser Glu           
65                  70                  75                  80            

aaa gat caa acc cag ggg cat gac cag tcc cag cat ctg act caa gaa        288
Lys Asp Gln Thr Gln Gly His Asp Gln Ser Gln His Leu Thr Gln Glu           
                85                  90                  95                

tac tta cct aaa gaa gcc cga caa aaa cag aca ttc atc aca tgg act        336
Tyr Leu Pro Lys Glu Ala Arg Gln Lys Gln Thr Phe Ile Thr Trp Thr           
            100                 105                 110                   

caa aaa aac agg cta gtg caa gcc ttt gag agg aac cca ttc cct gat        384
Gln Lys Asn Arg Leu Val Gln Ala Phe Glu Arg Asn Pro Phe Pro Asp           
        115                 120                 125                       

att gct acc aga aaa aaa ctg gct gaa caa aca ggc ctg cag gaa tca        432
Ile Ala Thr Arg Lys Lys Leu Ala Glu Gln Thr Gly Leu Gln Glu Ser           
    130                 135                 140                           

aga att caa atg tgg ttt cag aaa caa aga tct ctg tac ctc aag aag        480
Arg Ile Gln Met Trp Phe Gln Lys Gln Arg Ser Leu Tyr Leu Lys Lys           
145                 150                 155                 160           

agc aga atg gag ccc atg aat tta ttg gta gac gac cca aat gag aga        528
Ser Arg Met Glu Pro Met Asn Leu Leu Val Asp Asp Pro Asn Glu Arg           
                165                 170                 175               

cca gat gca act gtt ggg tgg cat cca atc aac ctg ttc ctc ccc aca        576
Pro Asp Ala Thr Val Gly Trp His Pro Ile Asn Leu Phe Leu Pro Thr           
            180                 185                 190                   

gac agc tct cat tat ttt tct tgc tca cat tct tcc agc ggg cat gaa        624
Asp Ser Ser His Tyr Phe Ser Cys Ser His Ser Ser Ser Gly His Glu           
        195                 200                 205                       

act ctt cca cct gtt ctt cct tca acc cag gct cct tgg gat ccc ttc        672
Thr Leu Pro Pro Val Leu Pro Ser Thr Gln Ala Pro Trp Asp Pro Phe           
    210                 215                 220                           

agg ttc cat gtg agc caa gga cca aat gtc atg atc atg cag ccc aca        720
Arg Phe His Val Ser Gln Gly Pro Asn Val Met Ile Met Gln Pro Thr           
225                 230                 235                 240           

cag gct gtg cag gaa gga gag aag tct gat cag cct ctg ata att ccg        768
Gln Ala Val Gln Glu Gly Glu Lys Ser Asp Gln Pro Leu Ile Ile Pro           
                245                 250                 255               

aat cac ctc ctg aca ctg cca att ctg aca aag gac tta gat act ccg        816
Asn His Leu Leu Thr Leu Pro Ile Leu Thr Lys Asp Leu Asp Thr Pro           
            260                 265                 270                   

act ccc ttc tgg ctc caa tac caa gaa gaa cac caa aat cac aaa gaa        864
Thr Pro Phe Trp Leu Gln Tyr Gln Glu Glu His Gln Asn His Lys Glu           
        275                 280                 285                       

cac tct ggc tcg gga gta cca cag gtc aag agc cat tct cag cct gaa        912
His Ser Gly Ser Gly Val Pro Gln Val Lys Ser His Ser Gln Pro Glu           
    290                 295                 300                           

cct gag cac agg gag caa caa cct cta aat ctg ggt cag ttt gac ata        960
Pro Glu His Arg Glu Gln Gln Pro Leu Asn Leu Gly Gln Phe Asp Ile           
305                 310                 315                 320           

tcg aac att ttg caa agg tgg gac gag atc tgc cag gct ctg ctt gct       1008
Ser Asn Ile Leu Gln Arg Trp Asp Glu Ile Cys Gln Ala Leu Leu Ala           
                325                 330                 335               

gaa tgg gac cct ctc aaa ggg aca cac tga                               1038
Glu Trp Asp Pro Leu Lys Gly Thr His                                       
            340                 345                                       


<210>  144
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Asn Leu Glu Gly Thr Ser Gly Gly Ile Leu Gln Lys Glu Phe Trp 
1               5                   10                  15      


Arg Asn Arg Ile Gln Tyr Asn Gln Ser Gln Lys Asp Ile Leu Gln Ser 
            20                  25                  30          


Trp Phe Gln His Asp Pro Phe Pro Asp Lys Ala Ala Arg Glu Gln Leu 
        35                  40                  45              


Ala Lys Glu Ile Gly Val Pro Glu Ser Asn Ile Gln Val Trp Phe Lys 
    50                  55                  60                  


Asn Tyr Arg Val Lys Gln Arg Lys Leu Asp Tyr Lys Cys Phe Ser Glu 
65                  70                  75                  80  


Lys Asp Gln Thr Gln Gly His Asp Gln Ser Gln His Leu Thr Gln Glu 
                85                  90                  95      


Tyr Leu Pro Lys Glu Ala Arg Gln Lys Gln Thr Phe Ile Thr Trp Thr 
            100                 105                 110         


Gln Lys Asn Arg Leu Val Gln Ala Phe Glu Arg Asn Pro Phe Pro Asp 
        115                 120                 125             


Ile Ala Thr Arg Lys Lys Leu Ala Glu Gln Thr Gly Leu Gln Glu Ser 
    130                 135                 140                 


Arg Ile Gln Met Trp Phe Gln Lys Gln Arg Ser Leu Tyr Leu Lys Lys 
145                 150                 155                 160 


Ser Arg Met Glu Pro Met Asn Leu Leu Val Asp Asp Pro Asn Glu Arg 
                165                 170                 175     


Pro Asp Ala Thr Val Gly Trp His Pro Ile Asn Leu Phe Leu Pro Thr 
            180                 185                 190         


Asp Ser Ser His Tyr Phe Ser Cys Ser His Ser Ser Ser Gly His Glu 
        195                 200                 205             


Thr Leu Pro Pro Val Leu Pro Ser Thr Gln Ala Pro Trp Asp Pro Phe 
    210                 215                 220                 


Arg Phe His Val Ser Gln Gly Pro Asn Val Met Ile Met Gln Pro Thr 
225                 230                 235                 240 


Gln Ala Val Gln Glu Gly Glu Lys Ser Asp Gln Pro Leu Ile Ile Pro 
                245                 250                 255     


Asn His Leu Leu Thr Leu Pro Ile Leu Thr Lys Asp Leu Asp Thr Pro 
            260                 265                 270         


Thr Pro Phe Trp Leu Gln Tyr Gln Glu Glu His Gln Asn His Lys Glu 
        275                 280                 285             


His Ser Gly Ser Gly Val Pro Gln Val Lys Ser His Ser Gln Pro Glu 
    290                 295                 300                 


Pro Glu His Arg Glu Gln Gln Pro Leu Asn Leu Gly Gln Phe Asp Ile 
305                 310                 315                 320 


Ser Asn Ile Leu Gln Arg Trp Asp Glu Ile Cys Gln Ala Leu Leu Ala 
                325                 330                 335     


Glu Trp Asp Pro Leu Lys Gly Thr His 
            340                 345 


<210>  145
<211>  3946
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (10)..(3507)

<400>  145
gaggccacc atg cag gat gtc caa ggc ccc cgt ccc gga agc ccc ggg gat       51
          Met Gln Asp Val Gln Gly Pro Arg Pro Gly Ser Pro Gly Asp         
          1               5                   10                          

gct gaa gac cgg cgg gag ctg ggc ttg cac agg ggc gag gtc aac ttt         99
Ala Glu Asp Arg Arg Glu Leu Gly Leu His Arg Gly Glu Val Asn Phe           
15                  20                  25                  30            

gga ggg tct ggg aag aag cga ggc aag ttt gta cgg gtg ccg agc gga        147
Gly Gly Ser Gly Lys Lys Arg Gly Lys Phe Val Arg Val Pro Ser Gly           
                35                  40                  45                

gtg gcc ccg tct gtg ctc ttt gac ctg ctg ctt gct gag tgg cac ctg        195
Val Ala Pro Ser Val Leu Phe Asp Leu Leu Leu Ala Glu Trp His Leu           
            50                  55                  60                    

ccg gcc ccc aac ctg gtg gtg tcc ctg gtg ggt gag gag cag cct ttc        243
Pro Ala Pro Asn Leu Val Val Ser Leu Val Gly Glu Glu Gln Pro Phe           
        65                  70                  75                        

gcc atg aag tcc tgg ctg cgg gat gtg ctg cgc aag ggg ctg gtg aag        291
Ala Met Lys Ser Trp Leu Arg Asp Val Leu Arg Lys Gly Leu Val Lys           
    80                  85                  90                            

gcg gct cag agc aca gga gcc tgg atc ctg acc agt gcc ctc cgc gtg        339
Ala Ala Gln Ser Thr Gly Ala Trp Ile Leu Thr Ser Ala Leu Arg Val           
95                  100                 105                 110           

ggc ctg gcc agg cat gtc ggg cag gcc gtg cgc gac cac tcg ctg gcc        387
Gly Leu Ala Arg His Val Gly Gln Ala Val Arg Asp His Ser Leu Ala           
                115                 120                 125               

agc acg tcc acc aag gtc cgt gtg gtt gct gtc ggc atg gcc tcg ctg        435
Ser Thr Ser Thr Lys Val Arg Val Val Ala Val Gly Met Ala Ser Leu           
            130                 135                 140                   

ggc cgc gtc ctg cac cgc cgc att ctg gag gag gcc cag gag gat ttt        483
Gly Arg Val Leu His Arg Arg Ile Leu Glu Glu Ala Gln Glu Asp Phe           
        145                 150                 155                       

cct gtc cac tac cct gag gat gac ggc ggc agc cag ggc ccc ctc tgt        531
Pro Val His Tyr Pro Glu Asp Asp Gly Gly Ser Gln Gly Pro Leu Cys           
    160                 165                 170                           

tca ctg gac agc aac ctc tcc cac ttc atc ctg gtg gag cca ggc ccc        579
Ser Leu Asp Ser Asn Leu Ser His Phe Ile Leu Val Glu Pro Gly Pro           
175                 180                 185                 190           

ccg ggg aag ggc gat ggg ctg acg gag ctg cgg ctg agg ctg gag aag        627
Pro Gly Lys Gly Asp Gly Leu Thr Glu Leu Arg Leu Arg Leu Glu Lys           
                195                 200                 205               

cac atc tcg gag cag agg gcg ggc tac ggg ggc act ggc agc atc gag        675
His Ile Ser Glu Gln Arg Ala Gly Tyr Gly Gly Thr Gly Ser Ile Glu           
            210                 215                 220                   

atc cct gtc ctc tgc ttg ctg gtc aat ggt gat ccc aac acc ttg gag        723
Ile Pro Val Leu Cys Leu Leu Val Asn Gly Asp Pro Asn Thr Leu Glu           
        225                 230                 235                       

agg atc tcc agg gcc gtg gag cag gct gcc ccg tgg ctg atc ctg gta        771
Arg Ile Ser Arg Ala Val Glu Gln Ala Ala Pro Trp Leu Ile Leu Val           
    240                 245                 250                           

ggc tcg ggg ggc atc gcc gat gtg ctt gct gcc cta gtg aac cag ccc        819
Gly Ser Gly Gly Ile Ala Asp Val Leu Ala Ala Leu Val Asn Gln Pro           
255                 260                 265                 270           

cac ctc ctg gtg ccc aag gtg gcc gag aag cag ttt aag gag aag ttc        867
His Leu Leu Val Pro Lys Val Ala Glu Lys Gln Phe Lys Glu Lys Phe           
                275                 280                 285               

ccc agc aag cat ttc tct tgg gag gac atc gtg cgc tgg acc aag ctg        915
Pro Ser Lys His Phe Ser Trp Glu Asp Ile Val Arg Trp Thr Lys Leu           
            290                 295                 300                   

ctg cag aac atc acc tca cac cag cac ctg ctc acc gtg tat gac ttc        963
Leu Gln Asn Ile Thr Ser His Gln His Leu Leu Thr Val Tyr Asp Phe           
        305                 310                 315                       

gag cag gag ggc tcc gag gag ctg gac acg gtc atc ctg aag gcg ctg       1011
Glu Gln Glu Gly Ser Glu Glu Leu Asp Thr Val Ile Leu Lys Ala Leu           
    320                 325                 330                           

gtg aaa gcc tgc aag agc cac agc cag gag cct cag gac tat ctg gat       1059
Val Lys Ala Cys Lys Ser His Ser Gln Glu Pro Gln Asp Tyr Leu Asp           
335                 340                 345                 350           

gag ctc aag ctg gcc gtg gcc tgg gac cgc gtg gac atc gcc aag agt       1107
Glu Leu Lys Leu Ala Val Ala Trp Asp Arg Val Asp Ile Ala Lys Ser           
                355                 360                 365               

gag atc ttc aat ggg gac gtg gag tgg aag tcc tgt gac ctg gag gag       1155
Glu Ile Phe Asn Gly Asp Val Glu Trp Lys Ser Cys Asp Leu Glu Glu           
            370                 375                 380                   

gtg atg gtg gac gcc ctg gtc agc aac aag ccc gag ttt gtg cgc ctc       1203
Val Met Val Asp Ala Leu Val Ser Asn Lys Pro Glu Phe Val Arg Leu           
        385                 390                 395                       

ttt gtg gac aac ggc gca gac gtg gcc gac ttc ctg acg tat ggg cgg       1251
Phe Val Asp Asn Gly Ala Asp Val Ala Asp Phe Leu Thr Tyr Gly Arg           
    400                 405                 410                           

ctg cag gag ctc tac cgc tcc gtg tca cgc aag agc ctg ctc ttc gac       1299
Leu Gln Glu Leu Tyr Arg Ser Val Ser Arg Lys Ser Leu Leu Phe Asp           
415                 420                 425                 430           

ctg ctg cag cgg aag cag gag gag gcc cgg ctg acg ctg gcc ggc ctg       1347
Leu Leu Gln Arg Lys Gln Glu Glu Ala Arg Leu Thr Leu Ala Gly Leu           
                435                 440                 445               

ggc acc cag cag gcc cgg gag cca ccc gcg ggg cca ccg gcc ttc tcc       1395
Gly Thr Gln Gln Ala Arg Glu Pro Pro Ala Gly Pro Pro Ala Phe Ser           
            450                 455                 460                   

ctg cac gag gtc tcc cgc gta ctc aag gac ttc ctg cag gac gcc tgc       1443
Leu His Glu Val Ser Arg Val Leu Lys Asp Phe Leu Gln Asp Ala Cys           
        465                 470                 475                       

cga ggc ttc tac cag gac ggc cgg cca ggg gac cgc agg agg gcg gag       1491
Arg Gly Phe Tyr Gln Asp Gly Arg Pro Gly Asp Arg Arg Arg Ala Glu           
    480                 485                 490                           

aag ggc ccg gcc aag cgg ccc acg ggc cag aag tgg ctg ctg gac ctg       1539
Lys Gly Pro Ala Lys Arg Pro Thr Gly Gln Lys Trp Leu Leu Asp Leu           
495                 500                 505                 510           

aac cag aag agc gag aac ccc tgg cgg gac ctg ttc ctg tgg gcc gtg       1587
Asn Gln Lys Ser Glu Asn Pro Trp Arg Asp Leu Phe Leu Trp Ala Val           
                515                 520                 525               

ctg cag aac cgc cac gag atg gcc acc tac ttc tgg gcc atg ggc cag       1635
Leu Gln Asn Arg His Glu Met Ala Thr Tyr Phe Trp Ala Met Gly Gln           
            530                 535                 540                   

gaa ggt gtg gca gcc gca ctg gcc gcc tgc aaa atc ctc aaa gag atg       1683
Glu Gly Val Ala Ala Ala Leu Ala Ala Cys Lys Ile Leu Lys Glu Met           
        545                 550                 555                       

tcg cac ctg gag acg gag gcc gag gcg gcc cga gcc acg cgc gag gcg       1731
Ser His Leu Glu Thr Glu Ala Glu Ala Ala Arg Ala Thr Arg Glu Ala           
    560                 565                 570                           

aaa tac gag cgg ctg gcc ctt gac ctc ttc tcc gag tgc tac agc aac       1779
Lys Tyr Glu Arg Leu Ala Leu Asp Leu Phe Ser Glu Cys Tyr Ser Asn           
575                 580                 585                 590           

agt gag gcc cgc gcc ttc gcc ctg ctg gtg cgc cgg aac cgc tgc tgg       1827
Ser Glu Ala Arg Ala Phe Ala Leu Leu Val Arg Arg Asn Arg Cys Trp           
                595                 600                 605               

agc aag acc acc tgc ctg cac ctg gcc acc gag gct gac gcc aag gcc       1875
Ser Lys Thr Thr Cys Leu His Leu Ala Thr Glu Ala Asp Ala Lys Ala           
            610                 615                 620                   

ttc ttt gcc cac gac ggc gtt cag gcc ttc ctg acc agg atc tgg tgg       1923
Phe Phe Ala His Asp Gly Val Gln Ala Phe Leu Thr Arg Ile Trp Trp           
        625                 630                 635                       

ggg gac atg gcc gca ggc acg ccc atc ctg cgg ctg cta gga gcc ttc       1971
Gly Asp Met Ala Ala Gly Thr Pro Ile Leu Arg Leu Leu Gly Ala Phe           
    640                 645                 650                           

ctc tgc ccc gcc ctc gtc tat acc aac ctc atc acc ttc agt gag gaa       2019
Leu Cys Pro Ala Leu Val Tyr Thr Asn Leu Ile Thr Phe Ser Glu Glu           
655                 660                 665                 670           

gct ccc ctg agg aca ggc ctg gag gac ctg cag gac ctg gac agc ctg       2067
Ala Pro Leu Arg Thr Gly Leu Glu Asp Leu Gln Asp Leu Asp Ser Leu           
                675                 680                 685               

gac acg gag aag agc ccg ctg tat ggc ctg cag agc cgg gtg gag gag       2115
Asp Thr Glu Lys Ser Pro Leu Tyr Gly Leu Gln Ser Arg Val Glu Glu           
            690                 695                 700                   

ctg gtg gag gcg ccg agg gct cag ggt gac cga ggc cca cgt gct gtc       2163
Leu Val Glu Ala Pro Arg Ala Gln Gly Asp Arg Gly Pro Arg Ala Val           
        705                 710                 715                       

ttc ctg ctc aca cgc tgg cgg aaa ttc tgg ggc gct ccc gtg act gtg       2211
Phe Leu Leu Thr Arg Trp Arg Lys Phe Trp Gly Ala Pro Val Thr Val           
    720                 725                 730                           

ttc ctg ggg aac gtg gtc atg tac ttc gcc ttc ctc ttc ctg ttc acc       2259
Phe Leu Gly Asn Val Val Met Tyr Phe Ala Phe Leu Phe Leu Phe Thr           
735                 740                 745                 750           

tac gtc ctg ctg gtg gac ttc agg ccg ccc ccc cag ggc ccc tca ggg       2307
Tyr Val Leu Leu Val Asp Phe Arg Pro Pro Pro Gln Gly Pro Ser Gly           
                755                 760                 765               

ccc gag gtc acc ctc tac ttc tgg gtc ttt acg ctg gtg ctg gag gaa       2355
Pro Glu Val Thr Leu Tyr Phe Trp Val Phe Thr Leu Val Leu Glu Glu           
            770                 775                 780                   

atc cgg cag ggc ttc ttc aca gac gag gac aca cac ctg gtg aag aag       2403
Ile Arg Gln Gly Phe Phe Thr Asp Glu Asp Thr His Leu Val Lys Lys           
        785                 790                 795                       

ttc aca ctg tat gtg ggg gac aac tgg aac aag tgt gac atg gtg gcc       2451
Phe Thr Leu Tyr Val Gly Asp Asn Trp Asn Lys Cys Asp Met Val Ala           
    800                 805                 810                           

atc ttc ctg ttc atc gtg ggt gtc acc tgc agg atg ctg ccg tcg gcg       2499
Ile Phe Leu Phe Ile Val Gly Val Thr Cys Arg Met Leu Pro Ser Ala           
815                 820                 825                 830           

ttt gag gct ggc cgc aca gtc ctc gcc atg gac ttc atg gtg ttc acg       2547
Phe Glu Ala Gly Arg Thr Val Leu Ala Met Asp Phe Met Val Phe Thr           
                835                 840                 845               

ctg cgg ctg atc cat atc ttt gcc ata cac aag cag ctg ggc ccc aag       2595
Leu Arg Leu Ile His Ile Phe Ala Ile His Lys Gln Leu Gly Pro Lys           
            850                 855                 860                   

atc atc gtg gta gag cgc atg atg aag gac gtc ttc ttc ttc ctc ttc       2643
Ile Ile Val Val Glu Arg Met Met Lys Asp Val Phe Phe Phe Leu Phe           
        865                 870                 875                       

ttt ctg agc gtg tgg ctc gtg gcc tac ggt gtc acc acc cag gcg ctg       2691
Phe Leu Ser Val Trp Leu Val Ala Tyr Gly Val Thr Thr Gln Ala Leu           
    880                 885                 890                           

ctg cac ccc cat gac ggc cgc ctg gag tgg atc ttc cgc cgg gtg ctc       2739
Leu His Pro His Asp Gly Arg Leu Glu Trp Ile Phe Arg Arg Val Leu           
895                 900                 905                 910           

tac cgg ccc tac ctg cag atc ttc ggc cag atc cca ctg gac gag att       2787
Tyr Arg Pro Tyr Leu Gln Ile Phe Gly Gln Ile Pro Leu Asp Glu Ile           
                915                 920                 925               

gat gaa gcc cgt gtg aac tgc tcc acc cac cca ctg ctg ctg gag gac       2835
Asp Glu Ala Arg Val Asn Cys Ser Thr His Pro Leu Leu Leu Glu Asp           
            930                 935                 940                   

tca cca tcc tgc ccc agc ctc tat gcc aac tgg ctg gtc atc ctc ctg       2883
Ser Pro Ser Cys Pro Ser Leu Tyr Ala Asn Trp Leu Val Ile Leu Leu           
        945                 950                 955                       

ctg gtc acc ttc ctg ttg gtc acc aat gtg ctg ctc atg aac ctg ctc       2931
Leu Val Thr Phe Leu Leu Val Thr Asn Val Leu Leu Met Asn Leu Leu           
    960                 965                 970                           

atc gcc atg ttc agc tac acg ttc cag gtg gtg cag ggc aac gca gac       2979
Ile Ala Met Phe Ser Tyr Thr Phe Gln Val Val Gln Gly Asn Ala Asp           
975                 980                 985                 990           

atg ttc tgg aag ttc cag cgc tac aac ctg  att gtg gag tac cac  gag     3027
Met Phe Trp Lys Phe Gln Arg Tyr Asn Leu  Ile Val Glu Tyr His  Glu         
                995                 1000                 1005             

cgc ccc gcc ctg  gcc ccg ccc ttc atc  ctg ctc agc cac ctg  agc        3072
Arg Pro Ala Leu  Ala Pro Pro Phe Ile  Leu Leu Ser His Leu  Ser            
            1010                 1015                 1020                

ctg acg ctc cgc  cgg gtc ttc aag aag  gag gct gag cac aag  cgg        3117
Leu Thr Leu Arg  Arg Val Phe Lys Lys  Glu Ala Glu His Lys  Arg            
            1025                 1030                 1035                

gag cac ctg gag  aga gac ctg cca gac  ccc ctg gac cag aag  gtc        3162
Glu His Leu Glu  Arg Asp Leu Pro Asp  Pro Leu Asp Gln Lys  Val            
            1040                 1045                 1050                

gtc acc tgg gag  aca gtc cag aag gag  aac ttc ctg agc aag  atg        3207
Val Thr Trp Glu  Thr Val Gln Lys Glu  Asn Phe Leu Ser Lys  Met            
            1055                 1060                 1065                

gag aag cgg agg  agg gac agc gag ggg  gag gtg ctg cgg aaa  acc        3252
Glu Lys Arg Arg  Arg Asp Ser Glu Gly  Glu Val Leu Arg Lys  Thr            
            1070                 1075                 1080                

gcc cac aga gtg  gac ttc att gcc aag  tac ctc ggg ggt ctg  aga        3297
Ala His Arg Val  Asp Phe Ile Ala Lys  Tyr Leu Gly Gly Leu  Arg            
            1085                 1090                 1095                

gag caa gaa aag  cgc atc aag tgt ctg  gag tca cag atc aac  tac        3342
Glu Gln Glu Lys  Arg Ile Lys Cys Leu  Glu Ser Gln Ile Asn  Tyr            
            1100                 1105                 1110                

tgc tcg gtg ctc  gtg tcc tcc gtg gct  gac gtg ctg gcc cag  ggt        3387
Cys Ser Val Leu  Val Ser Ser Val Ala  Asp Val Leu Ala Gln  Gly            
            1115                 1120                 1125                

ggc ggc ccc cgg  agc tct cag cac tgt  ggc gag gga agc cag  ctg        3432
Gly Gly Pro Arg  Ser Ser Gln His Cys  Gly Glu Gly Ser Gln  Leu            
            1130                 1135                 1140                

gtg gct gct gac  cac aga ggt ggt tta  gat ggc tgg gaa caa  ccc        3477
Val Ala Ala Asp  His Arg Gly Gly Leu  Asp Gly Trp Glu Gln  Pro            
            1145                 1150                 1155                

ggg gct ggc cag  cct ccc tcg gac acc  tga gctgcttggc ctgccacgtg       3527
Gly Ala Gly Gln  Pro Pro Ser Asp Thr                                      
            1160                 1165                                     

tggggccacc tctcctcagc tggccaccct gcacgttgtg cactgacctt tgccgacctc     3587

cagcggaacc ccccaggggg caccagcccc ccagcagaca atggccctcc tggtgcctca     3647

ccacagaccc tcacccaaag gaaccgctcc ttgtccctcc tggcctcccc ggaggcacag     3707

cagtgtcatg gggctgtctc ccctgacagg cacaactccc cgggcagaaa acgtgcccca     3767

ccgcatccct acctggaaac tgaccagcct gcactgtgga aaagctggcc ctgtggcgtg     3827

acgggggagc acccccatcc agactgcgaa gctgctctgg ggtctgcacc cacccctgcc     3887

ctgacttgtg ttgcctgaca agagactcat ctttttttga aaaaaaaaaa aaaaaaaaa      3946


<210>  146
<211>  1165
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Gln Asp Val Gln Gly Pro Arg Pro Gly Ser Pro Gly Asp Ala Glu 
1               5                   10                  15      


Asp Arg Arg Glu Leu Gly Leu His Arg Gly Glu Val Asn Phe Gly Gly 
            20                  25                  30          


Ser Gly Lys Lys Arg Gly Lys Phe Val Arg Val Pro Ser Gly Val Ala 
        35                  40                  45              


Pro Ser Val Leu Phe Asp Leu Leu Leu Ala Glu Trp His Leu Pro Ala 
    50                  55                  60                  


Pro Asn Leu Val Val Ser Leu Val Gly Glu Glu Gln Pro Phe Ala Met 
65                  70                  75                  80  


Lys Ser Trp Leu Arg Asp Val Leu Arg Lys Gly Leu Val Lys Ala Ala 
                85                  90                  95      


Gln Ser Thr Gly Ala Trp Ile Leu Thr Ser Ala Leu Arg Val Gly Leu 
            100                 105                 110         


Ala Arg His Val Gly Gln Ala Val Arg Asp His Ser Leu Ala Ser Thr 
        115                 120                 125             


Ser Thr Lys Val Arg Val Val Ala Val Gly Met Ala Ser Leu Gly Arg 
    130                 135                 140                 


Val Leu His Arg Arg Ile Leu Glu Glu Ala Gln Glu Asp Phe Pro Val 
145                 150                 155                 160 


His Tyr Pro Glu Asp Asp Gly Gly Ser Gln Gly Pro Leu Cys Ser Leu 
                165                 170                 175     


Asp Ser Asn Leu Ser His Phe Ile Leu Val Glu Pro Gly Pro Pro Gly 
            180                 185                 190         


Lys Gly Asp Gly Leu Thr Glu Leu Arg Leu Arg Leu Glu Lys His Ile 
        195                 200                 205             


Ser Glu Gln Arg Ala Gly Tyr Gly Gly Thr Gly Ser Ile Glu Ile Pro 
    210                 215                 220                 


Val Leu Cys Leu Leu Val Asn Gly Asp Pro Asn Thr Leu Glu Arg Ile 
225                 230                 235                 240 


Ser Arg Ala Val Glu Gln Ala Ala Pro Trp Leu Ile Leu Val Gly Ser 
                245                 250                 255     


Gly Gly Ile Ala Asp Val Leu Ala Ala Leu Val Asn Gln Pro His Leu 
            260                 265                 270         


Leu Val Pro Lys Val Ala Glu Lys Gln Phe Lys Glu Lys Phe Pro Ser 
        275                 280                 285             


Lys His Phe Ser Trp Glu Asp Ile Val Arg Trp Thr Lys Leu Leu Gln 
    290                 295                 300                 


Asn Ile Thr Ser His Gln His Leu Leu Thr Val Tyr Asp Phe Glu Gln 
305                 310                 315                 320 


Glu Gly Ser Glu Glu Leu Asp Thr Val Ile Leu Lys Ala Leu Val Lys 
                325                 330                 335     


Ala Cys Lys Ser His Ser Gln Glu Pro Gln Asp Tyr Leu Asp Glu Leu 
            340                 345                 350         


Lys Leu Ala Val Ala Trp Asp Arg Val Asp Ile Ala Lys Ser Glu Ile 
        355                 360                 365             


Phe Asn Gly Asp Val Glu Trp Lys Ser Cys Asp Leu Glu Glu Val Met 
    370                 375                 380                 


Val Asp Ala Leu Val Ser Asn Lys Pro Glu Phe Val Arg Leu Phe Val 
385                 390                 395                 400 


Asp Asn Gly Ala Asp Val Ala Asp Phe Leu Thr Tyr Gly Arg Leu Gln 
                405                 410                 415     


Glu Leu Tyr Arg Ser Val Ser Arg Lys Ser Leu Leu Phe Asp Leu Leu 
            420                 425                 430         


Gln Arg Lys Gln Glu Glu Ala Arg Leu Thr Leu Ala Gly Leu Gly Thr 
        435                 440                 445             


Gln Gln Ala Arg Glu Pro Pro Ala Gly Pro Pro Ala Phe Ser Leu His 
    450                 455                 460                 


Glu Val Ser Arg Val Leu Lys Asp Phe Leu Gln Asp Ala Cys Arg Gly 
465                 470                 475                 480 


Phe Tyr Gln Asp Gly Arg Pro Gly Asp Arg Arg Arg Ala Glu Lys Gly 
                485                 490                 495     


Pro Ala Lys Arg Pro Thr Gly Gln Lys Trp Leu Leu Asp Leu Asn Gln 
            500                 505                 510         


Lys Ser Glu Asn Pro Trp Arg Asp Leu Phe Leu Trp Ala Val Leu Gln 
        515                 520                 525             


Asn Arg His Glu Met Ala Thr Tyr Phe Trp Ala Met Gly Gln Glu Gly 
    530                 535                 540                 


Val Ala Ala Ala Leu Ala Ala Cys Lys Ile Leu Lys Glu Met Ser His 
545                 550                 555                 560 


Leu Glu Thr Glu Ala Glu Ala Ala Arg Ala Thr Arg Glu Ala Lys Tyr 
                565                 570                 575     


Glu Arg Leu Ala Leu Asp Leu Phe Ser Glu Cys Tyr Ser Asn Ser Glu 
            580                 585                 590         


Ala Arg Ala Phe Ala Leu Leu Val Arg Arg Asn Arg Cys Trp Ser Lys 
        595                 600                 605             


Thr Thr Cys Leu His Leu Ala Thr Glu Ala Asp Ala Lys Ala Phe Phe 
    610                 615                 620                 


Ala His Asp Gly Val Gln Ala Phe Leu Thr Arg Ile Trp Trp Gly Asp 
625                 630                 635                 640 


Met Ala Ala Gly Thr Pro Ile Leu Arg Leu Leu Gly Ala Phe Leu Cys 
                645                 650                 655     


Pro Ala Leu Val Tyr Thr Asn Leu Ile Thr Phe Ser Glu Glu Ala Pro 
            660                 665                 670         


Leu Arg Thr Gly Leu Glu Asp Leu Gln Asp Leu Asp Ser Leu Asp Thr 
        675                 680                 685             


Glu Lys Ser Pro Leu Tyr Gly Leu Gln Ser Arg Val Glu Glu Leu Val 
    690                 695                 700                 


Glu Ala Pro Arg Ala Gln Gly Asp Arg Gly Pro Arg Ala Val Phe Leu 
705                 710                 715                 720 


Leu Thr Arg Trp Arg Lys Phe Trp Gly Ala Pro Val Thr Val Phe Leu 
                725                 730                 735     


Gly Asn Val Val Met Tyr Phe Ala Phe Leu Phe Leu Phe Thr Tyr Val 
            740                 745                 750         


Leu Leu Val Asp Phe Arg Pro Pro Pro Gln Gly Pro Ser Gly Pro Glu 
        755                 760                 765             


Val Thr Leu Tyr Phe Trp Val Phe Thr Leu Val Leu Glu Glu Ile Arg 
    770                 775                 780                 


Gln Gly Phe Phe Thr Asp Glu Asp Thr His Leu Val Lys Lys Phe Thr 
785                 790                 795                 800 


Leu Tyr Val Gly Asp Asn Trp Asn Lys Cys Asp Met Val Ala Ile Phe 
                805                 810                 815     


Leu Phe Ile Val Gly Val Thr Cys Arg Met Leu Pro Ser Ala Phe Glu 
            820                 825                 830         


Ala Gly Arg Thr Val Leu Ala Met Asp Phe Met Val Phe Thr Leu Arg 
        835                 840                 845             


Leu Ile His Ile Phe Ala Ile His Lys Gln Leu Gly Pro Lys Ile Ile 
    850                 855                 860                 


Val Val Glu Arg Met Met Lys Asp Val Phe Phe Phe Leu Phe Phe Leu 
865                 870                 875                 880 


Ser Val Trp Leu Val Ala Tyr Gly Val Thr Thr Gln Ala Leu Leu His 
                885                 890                 895     


Pro His Asp Gly Arg Leu Glu Trp Ile Phe Arg Arg Val Leu Tyr Arg 
            900                 905                 910         


Pro Tyr Leu Gln Ile Phe Gly Gln Ile Pro Leu Asp Glu Ile Asp Glu 
        915                 920                 925             


Ala Arg Val Asn Cys Ser Thr His Pro Leu Leu Leu Glu Asp Ser Pro 
    930                 935                 940                 


Ser Cys Pro Ser Leu Tyr Ala Asn Trp Leu Val Ile Leu Leu Leu Val 
945                 950                 955                 960 


Thr Phe Leu Leu Val Thr Asn Val Leu Leu Met Asn Leu Leu Ile Ala 
                965                 970                 975     


Met Phe Ser Tyr Thr Phe Gln Val Val Gln Gly Asn Ala Asp Met Phe 
            980                 985                 990         


Trp Lys Phe Gln Arg Tyr Asn Leu  Ile Val Glu Tyr His  Glu Arg Pro 
        995                 1000                 1005             


Ala Leu  Ala Pro Pro Phe Ile  Leu Leu Ser His Leu  Ser Leu Thr 
    1010                 1015                 1020             


Leu Arg  Arg Val Phe Lys Lys  Glu Ala Glu His Lys  Arg Glu His 
    1025                 1030                 1035             


Leu Glu  Arg Asp Leu Pro Asp  Pro Leu Asp Gln Lys  Val Val Thr 
    1040                 1045                 1050             


Trp Glu  Thr Val Gln Lys Glu  Asn Phe Leu Ser Lys  Met Glu Lys 
    1055                 1060                 1065             


Arg Arg  Arg Asp Ser Glu Gly  Glu Val Leu Arg Lys  Thr Ala His 
    1070                 1075                 1080             


Arg Val  Asp Phe Ile Ala Lys  Tyr Leu Gly Gly Leu  Arg Glu Gln 
    1085                 1090                 1095             


Glu Lys  Arg Ile Lys Cys Leu  Glu Ser Gln Ile Asn  Tyr Cys Ser 
    1100                 1105                 1110             


Val Leu  Val Ser Ser Val Ala  Asp Val Leu Ala Gln  Gly Gly Gly 
    1115                 1120                 1125             


Pro Arg  Ser Ser Gln His Cys  Gly Glu Gly Ser Gln  Leu Val Ala 
    1130                 1135                 1140             


Ala Asp  His Arg Gly Gly Leu  Asp Gly Trp Glu Gln  Pro Gly Ala 
    1145                 1150                 1155             


Gly Gln  Pro Pro Ser Asp Thr  
    1160                 1165 


<210>  147
<211>  539
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (9)..(356)

<400>  147
cgcccagc atg ccg agg agg agg aga cgc cga ggg tcc tcc ggt gct ggc        50
         Met Pro Arg Arg Arg Arg Arg Arg Gly Ser Ser Gly Ala Gly          
         1               5                   10                           

ggc cgg ggg cgg acc tgc tct cgc acc gtc cga gcg gag ctt tcg ttt         98
Gly Arg Gly Arg Thr Cys Ser Arg Thr Val Arg Ala Glu Leu Ser Phe           
15                  20                  25                  30            

tca gtg agc cag gtg gag cgc agt cta cgg gag ggc cac tac gct cag        146
Ser Val Ser Gln Val Glu Arg Ser Leu Arg Glu Gly His Tyr Ala Gln           
                35                  40                  45                

cgc ctg agt cgc acg gcg ccg gtc tac ctc gct gcg gtt att gag tac        194
Arg Leu Ser Arg Thr Ala Pro Val Tyr Leu Ala Ala Val Ile Glu Tyr           
            50                  55                  60                    

ctg acg gcc aag gtc ctg gag ctg gcg ggc aac gag gcc cag aac agc        242
Leu Thr Ala Lys Val Leu Glu Leu Ala Gly Asn Glu Ala Gln Asn Ser           
        65                  70                  75                        

gga gag cgg aac atc act ccc ctg ctg ctg gac atg gtg gtt cac aac        290
Gly Glu Arg Asn Ile Thr Pro Leu Leu Leu Asp Met Val Val His Asn           
    80                  85                  90                            

gac agg cta ctg agc acc ctt ttc aac acg acc acc atc tct caa gtg        338
Asp Arg Leu Leu Ser Thr Leu Phe Asn Thr Thr Thr Ile Ser Gln Val           
95                  100                 105                 110           

gcc cct ggc gag gac tag cttctgacac ccggcccctg ggacctgaca               386
Ala Pro Gly Glu Asp                                                       
                115                                                       

ggtccactcg tccacccacc cggccccaaa tcccccggcc tgaacccccg gccttaaaca      446

ccctcccccc acaacccagg ccccaaagtc ttgggccttc attaattctg tcaataaaat      506

gtttcaagga aaaaaaaaaa aaaaaaaaaa aaa                                   539


<210>  148
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Pro Arg Arg Arg Arg Arg Arg Gly Ser Ser Gly Ala Gly Gly Arg 
1               5                   10                  15      


Gly Arg Thr Cys Ser Arg Thr Val Arg Ala Glu Leu Ser Phe Ser Val 
            20                  25                  30          


Ser Gln Val Glu Arg Ser Leu Arg Glu Gly His Tyr Ala Gln Arg Leu 
        35                  40                  45              


Ser Arg Thr Ala Pro Val Tyr Leu Ala Ala Val Ile Glu Tyr Leu Thr 
    50                  55                  60                  


Ala Lys Val Leu Glu Leu Ala Gly Asn Glu Ala Gln Asn Ser Gly Glu 
65                  70                  75                  80  


Arg Asn Ile Thr Pro Leu Leu Leu Asp Met Val Val His Asn Asp Arg 
                85                  90                  95      


Leu Leu Ser Thr Leu Phe Asn Thr Thr Thr Ile Ser Gln Val Ala Pro 
            100                 105                 110         


Gly Glu Asp 
        115 


<210>  149
<211>  2092
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (414)..(968)

<400>  149
ggcgtaatta aaaagcggcg gaagaaggtg ggagggtcat gacgcagcga gtttcagtcg       60

tgacttttct gggggcatcg cggcgtcccc tttttttgcc tttaaagtaa aacgtcgccc      120

cgacgcaccc cccgcgtatt tcggggggcg gaggcggcgg gccacggcgc gaagaggggc      180

ggtgctgacg ccggccggtc acgtgggcgt gttgtggggg ggaggggcgc cgccgcgcgg      240

tcggttccgg gcggttggga gcgcgcgagc tagcgagcga gaggcagccg cgcccgccgc      300

cgcccctgct ctgtatgccg ctctctcccg gcgcggccgc cgccgatcac agcagcagga      360

gccaccgccg ccgcggttga tgtggttggg ccggggctga ggaggccgcc aag atg         416
                                                           Met            
                                                           1              

ccg cag tcc aag tcc cgg aag atc gcg atc ctg ggc tac cgg tct gtg        464
Pro Gln Ser Lys Ser Arg Lys Ile Ala Ile Leu Gly Tyr Arg Ser Val           
            5                   10                  15                    

ggg aaa tcc tca ttg acg att caa ttt gtt gaa ggc caa ttt gtg gac        512
Gly Lys Ser Ser Leu Thr Ile Gln Phe Val Glu Gly Gln Phe Val Asp           
        20                  25                  30                        

tcc tac gat cca acc ata gaa aac act ttt aca aag ttg atc aca gta        560
Ser Tyr Asp Pro Thr Ile Glu Asn Thr Phe Thr Lys Leu Ile Thr Val           
    35                  40                  45                            

aat gga caa gaa tat cat ctt caa ctt gta gac aca gcc ggg caa gat        608
Asn Gly Gln Glu Tyr His Leu Gln Leu Val Asp Thr Ala Gly Gln Asp           
50                  55                  60                  65            

gaa tat tct atc ttt cct cag aca tac tcc ata gat att aat ggc tat        656
Glu Tyr Ser Ile Phe Pro Gln Thr Tyr Ser Ile Asp Ile Asn Gly Tyr           
                70                  75                  80                

att ctt gtg tat tct gtt aca tca atc aaa agt ttt gaa gtg att aaa        704
Ile Leu Val Tyr Ser Val Thr Ser Ile Lys Ser Phe Glu Val Ile Lys           
            85                  90                  95                    

gtt atc cat ggc aaa ttg ttg gat atg gtg ggg aaa gta caa ata cct        752
Val Ile His Gly Lys Leu Leu Asp Met Val Gly Lys Val Gln Ile Pro           
        100                 105                 110                       

att atg ttg gtt ggg aat aag aaa gac ctg cat atg gaa agg gtg atc        800
Ile Met Leu Val Gly Asn Lys Lys Asp Leu His Met Glu Arg Val Ile           
    115                 120                 125                           

agt tat gaa gaa ggg aaa gct ttg gca gaa tct tgg aat gca gct ttt        848
Ser Tyr Glu Glu Gly Lys Ala Leu Ala Glu Ser Trp Asn Ala Ala Phe           
130                 135                 140                 145           

ttg gaa tct tct gct aaa gaa aat cag act gct gtg gat gtt ttt cga        896
Leu Glu Ser Ser Ala Lys Glu Asn Gln Thr Ala Val Asp Val Phe Arg           
                150                 155                 160               

agg ata att ttg gag gca gaa aaa atg gac ggg gca gct tca caa ggc        944
Arg Ile Ile Leu Glu Ala Glu Lys Met Asp Gly Ala Ala Ser Gln Gly           
            165                 170                 175                   

aag tct tca tgc tcg gtg atg tga ttctgctgca aagcctgagg acactgggaa       998
Lys Ser Ser Cys Ser Val Met                                               
        180                                                               

tatattctac ctgaagaagc aaactgcccg ttctccttga agataaacta tgcttctttt     1058

ttcttctgtt aacctgaaag atatcatttg ggtcagagct cccctccctt cagattatgt     1118

taactctgag tctgtccaaa tgagttcact tccattttca aattttaagc aatcatattt     1178

tcaatttata tattgtattt cttaatatta tgaccaagaa ttttatcggc attaattttt     1238

cagtgtagtt tgttgtttaa aataatgtaa tcatcaaaat gatgcatatt gttacactac     1298

tattaactag gcttcagtat atcagtgttt atttcattgt gttaaatgta tacttgtaaa     1358

taaaatagct gcaaacctca gtcctttgtg ctacttgatg tggctttcaa agaagagaag     1418

ccttgtcctg agtttctcac ttggcttcag gaaggcccca ggttggattc cagaaaccag     1478

tgaagatgtg gccacaggag gaggtgtgct gaggtggctg ctgaccgtgg actccctgcg     1538

cagtggcctg cagatgttgg ggctgggtta cagctgattg aagctgagtg gccctggggg     1598

gtctgtgagg ggagttcctc cccagtgatg aaattctctc cttccaccct caaatcccta     1658

gaccttgact gaaatgctcc gtggtcggga gcctggtcaa ggaggaggag ctgctgagag     1718

gcattgttcg cccttgctca tagcttagct cgatgtccgt gtcagacagg agatgattga     1778

gaacagcctt gcctgtcact gtcctagaac accctggagt ttagtgttct gtgtcagagt     1838

cttgggagcc tccttcagac ccagatgacg ggcctccctc tgtccaagga gcagctgtaa     1898

aggagaagag ggatttcatt tgtttggtgg ctgttacctt gtctgtaagt caaacttgga     1958

gttgagcagt gctttttaaa cgattccctt ttgcagctaa aatttcacag ggctatttct     2018

aatacgtaag caaatgttac cattgacttt attaataaaa tatagttttg ctttgcaaaa     2078

aaaaaaaaaa aaaa                                                       2092


<210>  150
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Pro Gln Ser Lys Ser Arg Lys Ile Ala Ile Leu Gly Tyr Arg Ser 
1               5                   10                  15      


Val Gly Lys Ser Ser Leu Thr Ile Gln Phe Val Glu Gly Gln Phe Val 
            20                  25                  30          


Asp Ser Tyr Asp Pro Thr Ile Glu Asn Thr Phe Thr Lys Leu Ile Thr 
        35                  40                  45              


Val Asn Gly Gln Glu Tyr His Leu Gln Leu Val Asp Thr Ala Gly Gln 
    50                  55                  60                  


Asp Glu Tyr Ser Ile Phe Pro Gln Thr Tyr Ser Ile Asp Ile Asn Gly 
65                  70                  75                  80  


Tyr Ile Leu Val Tyr Ser Val Thr Ser Ile Lys Ser Phe Glu Val Ile 
                85                  90                  95      


Lys Val Ile His Gly Lys Leu Leu Asp Met Val Gly Lys Val Gln Ile 
            100                 105                 110         


Pro Ile Met Leu Val Gly Asn Lys Lys Asp Leu His Met Glu Arg Val 
        115                 120                 125             


Ile Ser Tyr Glu Glu Gly Lys Ala Leu Ala Glu Ser Trp Asn Ala Ala 
    130                 135                 140                 


Phe Leu Glu Ser Ser Ala Lys Glu Asn Gln Thr Ala Val Asp Val Phe 
145                 150                 155                 160 


Arg Arg Ile Ile Leu Glu Ala Glu Lys Met Asp Gly Ala Ala Ser Gln 
                165                 170                 175     


Gly Lys Ser Ser Cys Ser Val Met 
            180                 


<210>  151
<211>  2607
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (270)..(635)

<400>  151
agtgttccag ttcaaagagt acctgctgca gttggtggaa gtataaagca ttttctgttt       60

gataagagaa ctggccaagg tgcccggctt ggtaggggat accagacaac caaaggccat      120

atatggactt ggcaatccac tggtccctgg acccggataa gtttccaggg aaggctgcat      180

agacagctat gaaagctggt cagtgaaagt gaaacctgtg tctttgcacc tgggcatcag      240

ctgcttggct ctccacttat gcactgtgt atg tct ctt gca tgc ctg agg aca        293
                                Met Ser Leu Ala Cys Leu Arg Thr           
                                1               5                         

ttc ttg ggg gtg gat gtt ttg caa gac ttg gca gct gtg cca cct gtc        341
Phe Leu Gly Val Asp Val Leu Gln Asp Leu Ala Ala Val Pro Pro Val           
    10                  15                  20                            

atg gac ttg atg gac cgt ttg aca aca gaa ctg gga tgg tgc cac tgt        389
Met Asp Leu Met Asp Arg Leu Thr Thr Glu Leu Gly Trp Cys His Cys           
25                  30                  35                  40            

gtg gtg gac ttg acc aat gca ttc ttc tca atc agc att gct cca gag        437
Val Val Asp Leu Thr Asn Ala Phe Phe Ser Ile Ser Ile Ala Pro Glu           
                45                  50                  55                

agc cag gaa cag ttt gcc ttc atg gga ggg cga caa tgg act ttc ata        485
Ser Gln Glu Gln Phe Ala Phe Met Gly Gly Arg Gln Trp Thr Phe Ile           
            60                  65                  70                    

gtg ttg ctg cag ggc tat atg tat agc ccc att ata tat cat ttt ctt        533
Val Leu Leu Gln Gly Tyr Met Tyr Ser Pro Ile Ile Tyr His Phe Leu           
        75                  80                  85                        

att aat gat gtt atg tta acc tct agt tct ttt gct ggt ttg gag gcc        581
Ile Asn Asp Val Met Leu Thr Ser Ser Ser Phe Ala Gly Leu Glu Ala           
    90                  95                  100                           

aca aca ccc ctc ttg cct ggg att ggg atg atg agg ctg aaa cag ccc        629
Thr Thr Pro Leu Leu Pro Gly Ile Gly Met Met Arg Leu Lys Gln Pro           
105                 110                 115                 120           

ttc tga tgacataagc cctctgggtg gttaaccagg gtgcccattt aaactagatg         685
Phe                                                                       
                                                                          

tgcatgtaac caccaataga gttggctagg gcctatggca gtatatggag tgcttggaag      745

cgccagtcag cttttagtcc cagctatgga agggagctga gccccagtgt tcattaataa      805

agaagcagtt agtaaccata tatgctgccc ttcaggttca taagagcgtg gctggatggg      865

ttacagtcgt gtggatggct taccccatag tgggatgggt gcgttcatga gcaatgaccc      925

ccccagactg ggacagcaca gacatccact ttagcgaagt ggggcaccta cttagagcag      985

tggagtacgc taagtataag tcccttagca gcagagttgc aagaggtctt ggaacctgta     1045

gtcctaatgc aagataaggc catggggcct ggggcacccc tagaccccga gccttcactg     1105

ttagaaaggg tgttcttcca ttcctaatag gacatggtac acagctatgt ctagttgggg     1165

tgccactgct gcctggactg ctggtgcagt ccagcctagt actgacacca tatggtttga     1225

aaccaggtgt agacagcggg gcagtcagga ttatcaatat cactgtttta cagcttcaca     1285

tcttagctga ctggaaagcc ttccaggagc agtaatatgc atggagctgt catctcctat     1345

gataacaatg ccttcttctg gaataccttc tgtaggatct gcctgaggct gttttacagt     1405

taactttttt taaataagta gaagtacact ctaaaatatt aaattggtgc aaaagtaatt     1465

gccgtttttg ccattgcagt tacttttgca ccaacctaat aacaataaaa agtaaggtaa     1525

atacacaaac cagtgatata gtactttcct atcaggtatt atatagtgct attttttttt     1585

tgagaccgag tctcactctt tacccagaat gcaggcagtg gcatgatctt ggctcacgac     1645

aacctctgcc tctcggattc aaccgattct tgtgcctcag cctcccaagt agctgggaat     1705

ataggtgtga gccaccacgc ctggctaatt tttgtatttt tagtagagac agggtttcat     1765

catgttggcc aggctggtct tgaactcctg acctcaggtg atccacccgc cttggcctcc     1825

caaagtgctg ggattacaag cgtgagccac cacactaggc ctttagtgct atacttttat     1885

atgattggca gtgcagtaag tttgtttaca ccagtatcac cacaaacata taattgtgct     1945

atgatgtcac tagttaatag gcattttcca gctccattat aatcttatgt gatcactgtc     2005

atttctgcag tccattattg accaaaatgt ccttgtgtgg ttcataactg tactcaaata     2065

tctacaaaga gagtttcttc tggtacccag taaatatttc attacttaat atactctccc     2125

ccctgctcct gcgaacctca ctccatccta agaacaatct tcgcatctgc ctttctggac     2185

tttctgctat gaactaaata tttattcacc agagaaactg ctgtatacta ggtgttatga     2245

aatataattt ttttatatca aagacattgt ataattacat gaagaccaat ggagtaattc     2305

atcttaattc taagtattag aaaagctttg ttttccttga agaatggaca tatttttttc     2365

cttctaaaac aatgtaagca aatgaccttc tcattttggt tgccagaatg ctcagtttgt     2425

atccctaact gactgcctgt gtaggttatc ataacttgtc ctgatctcct agtgctcatt     2485

tgtatgtgtt gttttctatt ttactgtatc ttgttcgcca tcttgagtca tttttttaca     2545

cacaatggag ttataataaa atagctattg cctattatga taaaagaaat accttctagc     2605

tt                                                                    2607


<210>  152
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Ser Leu Ala Cys Leu Arg Thr Phe Leu Gly Val Asp Val Leu Gln 
1               5                   10                  15      


Asp Leu Ala Ala Val Pro Pro Val Met Asp Leu Met Asp Arg Leu Thr 
            20                  25                  30          


Thr Glu Leu Gly Trp Cys His Cys Val Val Asp Leu Thr Asn Ala Phe 
        35                  40                  45              


Phe Ser Ile Ser Ile Ala Pro Glu Ser Gln Glu Gln Phe Ala Phe Met 
    50                  55                  60                  


Gly Gly Arg Gln Trp Thr Phe Ile Val Leu Leu Gln Gly Tyr Met Tyr 
65                  70                  75                  80  


Ser Pro Ile Ile Tyr His Phe Leu Ile Asn Asp Val Met Leu Thr Ser 
                85                  90                  95      


Ser Ser Phe Ala Gly Leu Glu Ala Thr Thr Pro Leu Leu Pro Gly Ile 
            100                 105                 110         


Gly Met Met Arg Leu Lys Gln Pro Phe 
        115                 120     


<210>  153
<211>  6202
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (169)..(1728)

<400>  153
gaattccggc gtcgcggacg catcccagtc tgggcgggac gctcggccgc ggcgaggcgg       60

gcaagcctgg cagggcagag ggagccccgg ctccgaggtt gctcttcgcc cccgaggatc      120

agtcttggcc ccaaagcgcg acgcacaaat ccacataacc tgaggacc atg gat gct       177
                                                     Met Asp Ala          
                                                     1                    

gat gag ggt caa gac atg tcc caa gtt tca ggg aag gaa agc ccc cct        225
Asp Glu Gly Gln Asp Met Ser Gln Val Ser Gly Lys Glu Ser Pro Pro           
    5                   10                  15                            

gta agc gat act cca gat gag ggc gat gag ccc atg ccg atc ccc gag        273
Val Ser Asp Thr Pro Asp Glu Gly Asp Glu Pro Met Pro Ile Pro Glu           
20                  25                  30                  35            

gac ctc tcc acc acc tcg gga gga cag caa agc tcc aag agt gac aga        321
Asp Leu Ser Thr Thr Ser Gly Gly Gln Gln Ser Ser Lys Ser Asp Arg           
                40                  45                  50                

gtc gtg gcc agt aat gtt aaa gta gag act cag agt gat gaa gag aat        369
Val Val Ala Ser Asn Val Lys Val Glu Thr Gln Ser Asp Glu Glu Asn           
            55                  60                  65                    

ggg cgt gcc tgt gaa atg aat ggg gaa gaa tgt gcg gag gat tta cga        417
Gly Arg Ala Cys Glu Met Asn Gly Glu Glu Cys Ala Glu Asp Leu Arg           
        70                  75                  80                        

atg ctt gat gcc tcg gga gag aaa atg aat ggc tcc cac agg gac caa        465
Met Leu Asp Ala Ser Gly Glu Lys Met Asn Gly Ser His Arg Asp Gln           
    85                  90                  95                            

ggc agc tcg gct ttg tcg gga gtt gga ggc att cga ctt cct aac gga        513
Gly Ser Ser Ala Leu Ser Gly Val Gly Gly Ile Arg Leu Pro Asn Gly           
100                 105                 110                 115           

aaa cta aag tgt gat atc tgt ggg atc att tgc atc ggg ccc aat gtg        561
Lys Leu Lys Cys Asp Ile Cys Gly Ile Ile Cys Ile Gly Pro Asn Val           
                120                 125                 130               

ctc atg gtt cac aaa aga agc cac act gga gaa cgg ccc ttc cag tgc        609
Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg Pro Phe Gln Cys           
            135                 140                 145                   

aat cag tgc ggg gcc tca ttc acc cag aag ggc aac ctg ctc cgg cac        657
Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu Leu Arg His           
        150                 155                 160                       

atc aag ctg cat tcc ggg gag aag ccc ttc aaa tgc cac ctc tgc aac        705
Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His Leu Cys Asn           
    165                 170                 175                           

tac gcc tgc cgc cgg agg gac gcc ctc act ggc cac ctg agg acg cac        753
Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu Arg Thr His           
180                 185                 190                 195           

tcc gtt ggt aaa cct cac aaa tgt gga tat tgt ggc cga agc tat aaa        801
Ser Val Gly Lys Pro His Lys Cys Gly Tyr Cys Gly Arg Ser Tyr Lys           
                200                 205                 210               

cag cga agc tct tta gag gaa cat aaa gag cgc tgc cac aac tac ttg        849
Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys His Asn Tyr Leu           
            215                 220                 225                   

gaa agc atg ggc ctt ccg ggc aca ctg tac cca gtc att aaa gaa gaa        897
Glu Ser Met Gly Leu Pro Gly Thr Leu Tyr Pro Val Ile Lys Glu Glu           
        230                 235                 240                       

act aat cac agt gaa atg gca gaa gac ctg tgc aag ata gga tca gag        945
Thr Asn His Ser Glu Met Ala Glu Asp Leu Cys Lys Ile Gly Ser Glu           
    245                 250                 255                           

aga tct ctc gtg ctg gac aga cta gca agt aac gtc gcc aaa cgt aag        993
Arg Ser Leu Val Leu Asp Arg Leu Ala Ser Asn Val Ala Lys Arg Lys           
260                 265                 270                 275           

agc tct atg cct cag aaa ttt ctt ggg gac aag ggc ctg tcc gac acg       1041
Ser Ser Met Pro Gln Lys Phe Leu Gly Asp Lys Gly Leu Ser Asp Thr           
                280                 285                 290               

ccc tac gac agc agc gcc agc tac gag aag gag aac gaa atg atg aag       1089
Pro Tyr Asp Ser Ser Ala Ser Tyr Glu Lys Glu Asn Glu Met Met Lys           
            295                 300                 305                   

tcc cac gtg atg gac caa gcc atc aac aac gcc atc aac tac ctg ggg       1137
Ser His Val Met Asp Gln Ala Ile Asn Asn Ala Ile Asn Tyr Leu Gly           
        310                 315                 320                       

gcc gag tcc ctg cgc ccg ctg gtg cag acg ccc ccg ggc ggt tcc gag       1185
Ala Glu Ser Leu Arg Pro Leu Val Gln Thr Pro Pro Gly Gly Ser Glu           
    325                 330                 335                           

gtg gtc ccg gtc atc agc ccg atg tac cag ctg cac aag ccg ctc gcg       1233
Val Val Pro Val Ile Ser Pro Met Tyr Gln Leu His Lys Pro Leu Ala           
340                 345                 350                 355           

gag ggc acc ccg cgc tcc aac cac tcg gcc cag gac agc gcc gtg gag       1281
Glu Gly Thr Pro Arg Ser Asn His Ser Ala Gln Asp Ser Ala Val Glu           
                360                 365                 370               

aac ctg ctg ctg ctc tcc aag gcc aag ttg gtg ccc tcg gag cgc gag       1329
Asn Leu Leu Leu Leu Ser Lys Ala Lys Leu Val Pro Ser Glu Arg Glu           
            375                 380                 385                   

gcg tcc ccg agc aac agc tgc caa gac tcc acg gac acc gag agc aac       1377
Ala Ser Pro Ser Asn Ser Cys Gln Asp Ser Thr Asp Thr Glu Ser Asn           
        390                 395                 400                       

aac gag gag cag cgc agc ggt ctc atc tac ctg acc aac cac atc gcc       1425
Asn Glu Glu Gln Arg Ser Gly Leu Ile Tyr Leu Thr Asn His Ile Ala           
    405                 410                 415                           

ccg cac gcg cgc aac ggg ctg tcg ctc aag gag gag cac cgc gcc tac       1473
Pro His Ala Arg Asn Gly Leu Ser Leu Lys Glu Glu His Arg Ala Tyr           
420                 425                 430                 435           

gac ctg ctg cgc gcc gcc tcc gag aac tcg cag gac gcg ctc cgc gtg       1521
Asp Leu Leu Arg Ala Ala Ser Glu Asn Ser Gln Asp Ala Leu Arg Val           
                440                 445                 450               

gtc agc acc agc ggg gag cag atg aag gtg tac aag tgc gaa cac tgc       1569
Val Ser Thr Ser Gly Glu Gln Met Lys Val Tyr Lys Cys Glu His Cys           
            455                 460                 465                   

cgg gtg ctc ttc ctg gat cac gtc atg tac acc atc cac atg ggc tgc       1617
Arg Val Leu Phe Leu Asp His Val Met Tyr Thr Ile His Met Gly Cys           
        470                 475                 480                       

cac ggc ttc cgt gat cct ttt gag tgc aac atg tgc ggc tac cac agc       1665
His Gly Phe Arg Asp Pro Phe Glu Cys Asn Met Cys Gly Tyr His Ser           
    485                 490                 495                           

cag gac cgg tac gag ttc tcg tcg cac ata acg cga ggg gag cac cgc       1713
Gln Asp Arg Tyr Glu Phe Ser Ser His Ile Thr Arg Gly Glu His Arg           
500                 505                 510                 515           

ttc cac atg agc taa agccctcccg cgcccccacc ccagaccccg agccacccca       1768
Phe His Met Ser                                                           
                                                                          

ggaaaagcac aaggactgcc gccttctcgc tcccgccagc agcatagact ggactggacc     1828

agacaatgtt gtgtttggat ttgtaactgt tttttgtttt ttgtttgagt tggttgattg     1888

gggtttgatt tgcttttgaa aagattttta tttttagagg cagggctgca ttgggagcat     1948

ccagaactgc taccttccta gatgtttccc cagaccgctg gctgagattc cctcacctgt     2008

cgcttcctag aatccccttc tccaaacgat tagtctaaat tttcagagag aaatagataa     2068

aacacgccac agcctgggaa ggagcgtgct ctaccctgtg ctaagcacgg ggttcgcgca     2128

ccaggtgtct ttttccagtc cccagaagca gagagcacag cccctgctgt gtgggtctgc     2188

aggtgagcag acaggacagg tgtgccgcca cccaagtgcc aagacacagc agggccaaca     2248

acctgtgccc aggccagctt cgagctacat gcatctaggg cggagaggct gcacttgtga     2308

gagaaaatac tatttcaagt catattctgc gtaggaaaat gaattggttg gggaaagtcg     2368

tgtctgtcag actgccctgg gtggagggag acgccgggct agagcctttg ggatcgtcct     2428

ggattcactg gctttgcgga ggctgctcag atggcctgag cctcccgagg cttgctgccc     2488

cgtaggagga gactgtcttc ccgtgggcat atctggggag ccctgttccc cgctttttca     2548

ctcccatacc tttaatggcc cccaaaatct gtcactacaa tttaaacacc agtcccgaaa     2608

tttggatctt ctttcttttt gaatctctca aacggcaaca ttcctcagaa accaaagctt     2668

tatttcaaat ctcttccttc cctggctggt tccatctagt accagaggcc tcttttcctg     2728

aagaaatcca atcctagccc tcattttaat tatgtacatc tgtttgtagc cacaagcctg     2788

aatttctcag tgttggtaag tttctttacc taccctcact atatattatt ctcgttttaa     2848

aacccataaa ggagtgattt agaacagtca ttaattttca actcaatgaa atatgtgaag     2908

cccagcatct ctgttgctaa cacacagagc tcacctgttt gaaaccaagc tttcaaacat     2968

gttgaagctc tttactgtaa aggcaagcca gcatgtgtgt ccacacatac ataggatggc     3028

tggctctgca cctgtaggat attggaatgc acagggcaat tgagggactg agccagacct     3088

tcggagagta atgccaccag atcccctagg aaagaggagg caaatggcac tgcaggtgag     3148

aaccccgccc atccgtgcta tgacatggag gcactgaagc ccgaggaagg tgtgtggaga     3208

ttctaatccc aacaagcaag ggtctccttc aagattaatg ctatcaatca ttaaggtcat     3268

tactctcaac cacctaggca atgaagaata taccatttca aatatttaca gtacttgtct     3328

tcaccaacac tgtcccaagg tgaaatgaag caacagagag gaaattgtac ataagtacct     3388

cagcatttaa tccaaacagg ggttcttagt ctcagcacta tgacattttg ggctgactac     3448

ttatttgtta ggcgggagct ctcctgtgca ttgtaggata attagcagta tccctggtgg     3508

ctacccaata gacgccagta gcaccccgaa ttgacaaccc aaactctcca gacatcacca     3568

actgtcccct gcgaggagaa atcactcctg ggggagaacc actgacccaa atgaattcta     3628

aaccaatcaa atgtctggga agccctccaa gaaaaaaaat agaaaagcac ttgaagaata     3688

ttcccaatat tcccggtcag cagtatcaag gctgacttgt gttcatgtgg agtcattata     3748

aattctataa atcaattatt ccccttcggt cttaaaaata tatttcctca taaacatttg     3808

agttttgttg aaaagatgga gtttacaaag ataccattct tgagtcatgg atttctctgc     3868

tcacagaagg gtgtggcatt tggaaacggg aataaacaaa attgctgcac caatgcactg     3928

agtgaaggaa gagagacaga ggatcaaggg ctttagacag cactccttca atatgcaatc     3988

acagagaaag atgcgcctta tccaagttaa tatctctaag gtgagagcct tcttagagtc     4048

agtttgttgc aaatttcacc tactctgttc ttttccatcc atccccctga gtcagttggt     4108

tgaagggagt tattttttca agtggaattc aaacaaagct caaaccagaa ctgtaaatag     4168

tgattgcagg aattcttttc taaactgctt tgccctttcc tctcactgcc ttttatagcc     4228

aatataaatg tctctttgca caccttttgt tgtggtttta tattgtaaca ccatttttct     4288

ttgaaactat tgtatttaaa gtaaggtttc atattatgtc agcaagtaat taacttatgt     4348

ttaaaaggtg gccatatcat gtaccaaaag ttgctgaagt ttctcttcta gctggtaaag     4408

taggagtttg catgacttca cacttttttt gcgtagtttc ttctgttgta tgatggcgtg     4468

agtgtgtgtc ttgggtaccg ctgtgtacta ctgtgtgcct agattccatg cactctcgtt     4528

gtgtttgaag taaatattgg agaccggagg gtaacaggtt ggcctgttga ttacagctag     4588

taatcgctgt gtcttgttcc gccccctccc tgacacccca gcttcccagg atgtggaaag     4648

cctggatctc agctccttgc cccatatccc ttctgtaatt tgtacctaaa gagtgtgatt     4708

atcctaattc aagagtcact aaaactcatc acattatcat tgcatatcag caaagggtaa     4768

agtcctagca ccaattgctt cacataccag catgttccat ttccaattta gaattagcca     4828

cataataaaa tcttagaatc ttccttgaga aagagctgcc tgagatgtag ttttgttata     4888

tggttcccca ccgaccattt ttgtgctttt ttcttgtttt gttttgtttt gactgcactg     4948

tgagttttgt agtgtcctct tcttgccaaa acaaacgcga gatgaactgg acttatgtag     5008

acaaatcgtg atgccagtgt atccttcctt tcttcagttc cagcaataat gaatggtcaa     5068

cttttttaaa atctagatct ctctcattca tttcaatgta tttttacttt aagatgaacc     5128

aaaattatta gacttattta agatgtacag gcatcagaaa aaagaagcac ataatgcttt     5188

tggtgcgatg gcactcactg tgaacatgtg taaccacata ttaatatgca atattgtttc     5248

caatactttc taatacagtt ttttataatg ttgtgtgtgg tgattgttca ggtcgaatct     5308

gttgtatcca gtacagcttt aggtcttcag ctgcccttct ggcgagtaca tgcacaggat     5368

tgtaaatgag aaatgcagtc atatttccag tctgcctcta tgatgatgtt aaattattgc     5428

tgtttagctg tgaacaaggg atgtaccact ggaggaatag agtatccttt tgtacacatt     5488

ttgaaatgct tcttctgtag tgatagaaca aataaatgca acgaatactc tgtctgccct     5548

atcccgtgaa gtccacactg gcgtaagaga aggcccagca gagcaggaat ctgcctagac     5608

tttctcccaa tgagatccca atatgagagg gagaagagat gggcctcagg acagctgcaa     5668

taccacttgg gaacacatgt ggtgtcttga tgtggccagc gcagcagttc agcacaacgt     5728

acctcccatc tacaacagtg ctggacgtgg gaattctaag tcccagtctt gagggtgggt     5788

ggagatggag ggcaacaaga gatacatttc cagttctcca ctgcagcatg cttcagtcat     5848

tctgtgagtg gccgggccca gggccctcac aatttcacta ccttgtcttt tacatagtca     5908

taagaattat cctcaacata gccttttgac gctgtaaatc ttgagtattc atttaccctt     5968

ttctgatctc ctggaaacag ctgcctgcct gcattgcact tctcttcccg aggagtgggg     6028

taaatttaaa agtcaagtta tagtttggat gttagtatag aattttgaaa ttgggaatta     6088

aaaatcagga ctggggactg ggagaccaaa aatttctgat cccatttctg atggatgtgt     6148

cacacctttt ctgtcaaaat aaaatgtctt ggaggttatg actccttggt gaaa           6202


<210>  154
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Asp Ala Asp Glu Gly Gln Asp Met Ser Gln Val Ser Gly Lys Glu 
1               5                   10                  15      


Ser Pro Pro Val Ser Asp Thr Pro Asp Glu Gly Asp Glu Pro Met Pro 
            20                  25                  30          


Ile Pro Glu Asp Leu Ser Thr Thr Ser Gly Gly Gln Gln Ser Ser Lys 
        35                  40                  45              


Ser Asp Arg Val Val Ala Ser Asn Val Lys Val Glu Thr Gln Ser Asp 
    50                  55                  60                  


Glu Glu Asn Gly Arg Ala Cys Glu Met Asn Gly Glu Glu Cys Ala Glu 
65                  70                  75                  80  


Asp Leu Arg Met Leu Asp Ala Ser Gly Glu Lys Met Asn Gly Ser His 
                85                  90                  95      


Arg Asp Gln Gly Ser Ser Ala Leu Ser Gly Val Gly Gly Ile Arg Leu 
            100                 105                 110         


Pro Asn Gly Lys Leu Lys Cys Asp Ile Cys Gly Ile Ile Cys Ile Gly 
        115                 120                 125             


Pro Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg Pro 
    130                 135                 140                 


Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu 
145                 150                 155                 160 


Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His 
                165                 170                 175     


Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu 
            180                 185                 190         


Arg Thr His Ser Val Gly Lys Pro His Lys Cys Gly Tyr Cys Gly Arg 
        195                 200                 205             


Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys His 
    210                 215                 220                 


Asn Tyr Leu Glu Ser Met Gly Leu Pro Gly Thr Leu Tyr Pro Val Ile 
225                 230                 235                 240 


Lys Glu Glu Thr Asn His Ser Glu Met Ala Glu Asp Leu Cys Lys Ile 
                245                 250                 255     


Gly Ser Glu Arg Ser Leu Val Leu Asp Arg Leu Ala Ser Asn Val Ala 
            260                 265                 270         


Lys Arg Lys Ser Ser Met Pro Gln Lys Phe Leu Gly Asp Lys Gly Leu 
        275                 280                 285             


Ser Asp Thr Pro Tyr Asp Ser Ser Ala Ser Tyr Glu Lys Glu Asn Glu 
    290                 295                 300                 


Met Met Lys Ser His Val Met Asp Gln Ala Ile Asn Asn Ala Ile Asn 
305                 310                 315                 320 


Tyr Leu Gly Ala Glu Ser Leu Arg Pro Leu Val Gln Thr Pro Pro Gly 
                325                 330                 335     


Gly Ser Glu Val Val Pro Val Ile Ser Pro Met Tyr Gln Leu His Lys 
            340                 345                 350         


Pro Leu Ala Glu Gly Thr Pro Arg Ser Asn His Ser Ala Gln Asp Ser 
        355                 360                 365             


Ala Val Glu Asn Leu Leu Leu Leu Ser Lys Ala Lys Leu Val Pro Ser 
    370                 375                 380                 


Glu Arg Glu Ala Ser Pro Ser Asn Ser Cys Gln Asp Ser Thr Asp Thr 
385                 390                 395                 400 


Glu Ser Asn Asn Glu Glu Gln Arg Ser Gly Leu Ile Tyr Leu Thr Asn 
                405                 410                 415     


His Ile Ala Pro His Ala Arg Asn Gly Leu Ser Leu Lys Glu Glu His 
            420                 425                 430         


Arg Ala Tyr Asp Leu Leu Arg Ala Ala Ser Glu Asn Ser Gln Asp Ala 
        435                 440                 445             


Leu Arg Val Val Ser Thr Ser Gly Glu Gln Met Lys Val Tyr Lys Cys 
    450                 455                 460                 


Glu His Cys Arg Val Leu Phe Leu Asp His Val Met Tyr Thr Ile His 
465                 470                 475                 480 


Met Gly Cys His Gly Phe Arg Asp Pro Phe Glu Cys Asn Met Cys Gly 
                485                 490                 495     


Tyr His Ser Gln Asp Arg Tyr Glu Phe Ser Ser His Ile Thr Arg Gly 
            500                 505                 510         


Glu His Arg Phe His Met Ser 
        515                 


<210>  155
<211>  18883
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (388)..(15996)

<400>  155
tgtttgctct gcagaatact ttacctgggc acccaagtct tccttccagc attcctgctg       60

ctacagccta tttgctgagt aaccaggggt tacagcagcg ttgccaggca acgagggaca      120

gcggtcctgt tgaagagcca tttgtcacac tgaggggact ggttgaaatg caataaagaa      180

atgataccag cagctactca tgtcttcgcc attgctaaga acgtcgttgg tattacctta      240

ctctgagaac gtgtctgcag tttccagaaa atggagtatc gcaacatcac ttaaagtacc      300

ctgcttcaaa gtattgctgg caagtggcgt gggcctgatt atttatttag aaatgcttta      360

tcaggaggag aatgcttttt tgtaaac atg aat tgc cca gtt ctt tca ttg ggc      414
                              Met Asn Cys Pro Val Leu Ser Leu Gly         
                              1               5                           

tct ggc ttc ttg ttt cag gtc att gaa atg ttg atc ttt gcc tat ttt        462
Ser Gly Phe Leu Phe Gln Val Ile Glu Met Leu Ile Phe Ala Tyr Phe           
10                  15                  20                  25            

gct tca ata tcc ttg act gag tca cga ggt ctt ttc cca agg ctg gag        510
Ala Ser Ile Ser Leu Thr Glu Ser Arg Gly Leu Phe Pro Arg Leu Glu           
                30                  35                  40                

aac gtg gga gct ttc aag aaa gtt tcc atc gtg cca acc caa gca gta        558
Asn Val Gly Ala Phe Lys Lys Val Ser Ile Val Pro Thr Gln Ala Val           
            45                  50                  55                    

tgt gga ctc cca gac cga agc act ttt tgt cac agc tct gct gct gct        606
Cys Gly Leu Pro Asp Arg Ser Thr Phe Cys His Ser Ser Ala Ala Ala           
        60                  65                  70                        

gaa agt att cag ttc tgt acc cag cgg ttt tgt att cag gat tgc cca        654
Glu Ser Ile Gln Phe Cys Thr Gln Arg Phe Cys Ile Gln Asp Cys Pro           
    75                  80                  85                            

tac aga tct tca cac cct acc tac act gcc ctt ttc tca gca ggc ctc        702
Tyr Arg Ser Ser His Pro Thr Tyr Thr Ala Leu Phe Ser Ala Gly Leu           
90                  95                  100                 105           

agt agc tgc atc aca cca gac aag aat gat ctg cat cct aac gcc cat        750
Ser Ser Cys Ile Thr Pro Asp Lys Asn Asp Leu His Pro Asn Ala His           
                110                 115                 120               

agc aat tct gca agt ttt att ttt gga aat cac aag agc tgc ttt tct        798
Ser Asn Ser Ala Ser Phe Ile Phe Gly Asn His Lys Ser Cys Phe Ser           
            125                 130                 135                   

tct cct cct tct cca aag ctg atg gca tca ttt acc tta gct gta tgg        846
Ser Pro Pro Ser Pro Lys Leu Met Ala Ser Phe Thr Leu Ala Val Trp           
        140                 145                 150                       

ctg aaa cct gag caa caa ggt gta atg tgt gtt ata gaa aag aca gta        894
Leu Lys Pro Glu Gln Gln Gly Val Met Cys Val Ile Glu Lys Thr Val           
    155                 160                 165                           

gat ggg cag att gtg ttc aaa ctt aca ata tct gag aaa gag acc atg        942
Asp Gly Gln Ile Val Phe Lys Leu Thr Ile Ser Glu Lys Glu Thr Met           
170                 175                 180                 185           

ttt tat tat cgc aca gta aat ggt ttg caa cct cca ata aaa gta atg        990
Phe Tyr Tyr Arg Thr Val Asn Gly Leu Gln Pro Pro Ile Lys Val Met           
                190                 195                 200               

aca ctg ggg aga att ctt gtg aag aaa tgg att cat ctt agt gtg cag       1038
Thr Leu Gly Arg Ile Leu Val Lys Lys Trp Ile His Leu Ser Val Gln           
            205                 210                 215                   

gtg cat cag aca aaa atc agc ttc ttt atc aat ggc gtg gag aag gat       1086
Val His Gln Thr Lys Ile Ser Phe Phe Ile Asn Gly Val Glu Lys Asp           
        220                 225                 230                       

cat aca cct ttc aat gca aga act cta agt ggt tca att aca gat ttt       1134
His Thr Pro Phe Asn Ala Arg Thr Leu Ser Gly Ser Ile Thr Asp Phe           
    235                 240                 245                           

gca tct ggt act gtg caa ata gga cag agt tta aat ggt tta gag cag       1182
Ala Ser Gly Thr Val Gln Ile Gly Gln Ser Leu Asn Gly Leu Glu Gln           
250                 255                 260                 265           

ttt gtc gga aga atg caa gat ttt cga tta tac caa gtg gca ctt aca       1230
Phe Val Gly Arg Met Gln Asp Phe Arg Leu Tyr Gln Val Ala Leu Thr           
                270                 275                 280               

aac aga gag att ctg gaa gtc ttc tct gga gat ctt ctc aga ttg cat       1278
Asn Arg Glu Ile Leu Glu Val Phe Ser Gly Asp Leu Leu Arg Leu His           
            285                 290                 295                   

gcc caa tca cat tgc cgt tgc cct ggc agc cac ccg cgg gtc cac cct       1326
Ala Gln Ser His Cys Arg Cys Pro Gly Ser His Pro Arg Val His Pro           
        300                 305                 310                       

ttg gca cag cgg tac tgc att cct aat gat gca gga gac aca gct gat       1374
Leu Ala Gln Arg Tyr Cys Ile Pro Asn Asp Ala Gly Asp Thr Ala Asp           
    315                 320                 325                           

aat aga gtg tca cgg ttg aat cct gaa gcc cat cct ctc tct ttt gtc       1422
Asn Arg Val Ser Arg Leu Asn Pro Glu Ala His Pro Leu Ser Phe Val           
330                 335                 340                 345           

aat gat aat gat gtt ggt act tca tgg gtt tca aat gtg ttt aca aac       1470
Asn Asp Asn Asp Val Gly Thr Ser Trp Val Ser Asn Val Phe Thr Asn           
                350                 355                 360               

att aca cag ctt aat caa gga gtg act att tca gtt gat ttg gaa aat       1518
Ile Thr Gln Leu Asn Gln Gly Val Thr Ile Ser Val Asp Leu Glu Asn           
            365                 370                 375                   

gga cag tat cag gtg ttt tat att atc att cag ttc ttt agt cca caa       1566
Gly Gln Tyr Gln Val Phe Tyr Ile Ile Ile Gln Phe Phe Ser Pro Gln           
        380                 385                 390                       

cca acg gaa ata agg att caa agg aag aag gaa aat agt tta gat tgg       1614
Pro Thr Glu Ile Arg Ile Gln Arg Lys Lys Glu Asn Ser Leu Asp Trp           
    395                 400                 405                           

gag gac tgg caa tat ttt gcc agg aat tgt ggt gct ttt gga atg aaa       1662
Glu Asp Trp Gln Tyr Phe Ala Arg Asn Cys Gly Ala Phe Gly Met Lys           
410                 415                 420                 425           

aac aat gga gat ttg gaa aaa cct gat tct gtc aac tgt ctt cag ctt       1710
Asn Asn Gly Asp Leu Glu Lys Pro Asp Ser Val Asn Cys Leu Gln Leu           
                430                 435                 440               

tcc aat ttt act cca tat tcc cgt ggc aat gtc aca ttt agc atc ctg       1758
Ser Asn Phe Thr Pro Tyr Ser Arg Gly Asn Val Thr Phe Ser Ile Leu           
            445                 450                 455                   

aca cct gga cca aat tat cgt cct gga tac aat aac ttc tat aat acc       1806
Thr Pro Gly Pro Asn Tyr Arg Pro Gly Tyr Asn Asn Phe Tyr Asn Thr           
        460                 465                 470                       

cca tct ctt caa gag ttc gta aaa gcc acg caa ata agg ttt cat ttt       1854
Pro Ser Leu Gln Glu Phe Val Lys Ala Thr Gln Ile Arg Phe His Phe           
    475                 480                 485                           

cat ggg cag tac tat aca act gag act gct gtt aac ctc aga cac aga       1902
His Gly Gln Tyr Tyr Thr Thr Glu Thr Ala Val Asn Leu Arg His Arg           
490                 495                 500                 505           

tat tat gca gtg gac gaa atc acc att agt ggg aga tgt cag tgc cat       1950
Tyr Tyr Ala Val Asp Glu Ile Thr Ile Ser Gly Arg Cys Gln Cys His           
                510                 515                 520               

ggt cat gcc gat aac tgc gac aca aca agc cag cca tat aga tgc ctc       1998
Gly His Ala Asp Asn Cys Asp Thr Thr Ser Gln Pro Tyr Arg Cys Leu           
            525                 530                 535                   

tgc tcc cag gag agc ttc act gaa gga ctt cat tgt gat cgc tgc ttg       2046
Cys Ser Gln Glu Ser Phe Thr Glu Gly Leu His Cys Asp Arg Cys Leu           
        540                 545                 550                       

cct ctt tat aat gac aag cct ttc cgc caa ggt gat caa gtt tac gct       2094
Pro Leu Tyr Asn Asp Lys Pro Phe Arg Gln Gly Asp Gln Val Tyr Ala           
    555                 560                 565                           

ttc aat tgt aaa cct tgt caa tgc aac agc cat tcc aaa agc tgc cat       2142
Phe Asn Cys Lys Pro Cys Gln Cys Asn Ser His Ser Lys Ser Cys His           
570                 575                 580                 585           

tac aac atc tct gta gac cca ttt cct ttt gag cac ttc aga ggg gga       2190
Tyr Asn Ile Ser Val Asp Pro Phe Pro Phe Glu His Phe Arg Gly Gly           
                590                 595                 600               

gga gga gtt tgt gat gat tgt gag cat aac act aca gga agg aac tgt       2238
Gly Gly Val Cys Asp Asp Cys Glu His Asn Thr Thr Gly Arg Asn Cys           
            605                 610                 615                   

gag ctg tgc aag gat tac ttt ttc cga caa gtt ggt gca gat cct tcg       2286
Glu Leu Cys Lys Asp Tyr Phe Phe Arg Gln Val Gly Ala Asp Pro Ser           
        620                 625                 630                       

gcc ata gat gtt tgc aaa ccc tgt gac tgt gat aca gtt ggc act aga       2334
Ala Ile Asp Val Cys Lys Pro Cys Asp Cys Asp Thr Val Gly Thr Arg           
    635                 640                 645                           

aat ggt agc att ctt tgt gat cag att gga gga cag tgt aat tgt aag       2382
Asn Gly Ser Ile Leu Cys Asp Gln Ile Gly Gly Gln Cys Asn Cys Lys           
650                 655                 660                 665           

aga cac gtg tct ggc agg cag tgc aat cag tgc cag aat gga ttc tac       2430
Arg His Val Ser Gly Arg Gln Cys Asn Gln Cys Gln Asn Gly Phe Tyr           
                670                 675                 680               

aat cta caa gag ttg gat cct gat ggc tgc agt ccc tgt aac tgc aat       2478
Asn Leu Gln Glu Leu Asp Pro Asp Gly Cys Ser Pro Cys Asn Cys Asn           
            685                 690                 695                   

acc tct ggg aca gtg gat gga gat att acc tgt cac caa aat tca ggc       2526
Thr Ser Gly Thr Val Asp Gly Asp Ile Thr Cys His Gln Asn Ser Gly           
        700                 705                 710                       

cag tgc aag tgc aaa gca aac gtt att ggg ctt agg tgt gat cat tgc       2574
Gln Cys Lys Cys Lys Ala Asn Val Ile Gly Leu Arg Cys Asp His Cys           
    715                 720                 725                           

aat ttt gga ttt aaa ttt ctc cga agc ttt aat gat gtt gga tgt gag       2622
Asn Phe Gly Phe Lys Phe Leu Arg Ser Phe Asn Asp Val Gly Cys Glu           
730                 735                 740                 745           

ccc tgc cag tgt aac ctc cat ggc tca gtg aac aaa ttc tgc aat cct       2670
Pro Cys Gln Cys Asn Leu His Gly Ser Val Asn Lys Phe Cys Asn Pro           
                750                 755                 760               

cac tct ggg cag tgt gag tgc aaa aaa gaa gcc aaa gga ctt cag tgt       2718
His Ser Gly Gln Cys Glu Cys Lys Lys Glu Ala Lys Gly Leu Gln Cys           
            765                 770                 775                   

gac acc tgc aga gaa aac ttt tat ggg tta gat gtc acc aat tgt aag       2766
Asp Thr Cys Arg Glu Asn Phe Tyr Gly Leu Asp Val Thr Asn Cys Lys           
        780                 785                 790                       

gcc tgt gac tgt gac aca gct gga tcc ctc cct ggg act gtc tgt aat       2814
Ala Cys Asp Cys Asp Thr Ala Gly Ser Leu Pro Gly Thr Val Cys Asn           
    795                 800                 805                           

gct aag aca ggg cag tgc atc tgc aag ccc aat gtt gaa ggg aga cag       2862
Ala Lys Thr Gly Gln Cys Ile Cys Lys Pro Asn Val Glu Gly Arg Gln           
810                 815                 820                 825           

tgc aat aaa tgt ttg gag gga aac ttc tac cta cgg caa aat aat tct       2910
Cys Asn Lys Cys Leu Glu Gly Asn Phe Tyr Leu Arg Gln Asn Asn Ser           
                830                 835                 840               

ttc ctc tgt ctg cct tgc aac tgt gat aag act ggg aca ata aat ggc       2958
Phe Leu Cys Leu Pro Cys Asn Cys Asp Lys Thr Gly Thr Ile Asn Gly           
            845                 850                 855                   

tct ctg ctg tgt aac aaa tca aca gga caa tgt cct tgc aaa tta ggg       3006
Ser Leu Leu Cys Asn Lys Ser Thr Gly Gln Cys Pro Cys Lys Leu Gly           
        860                 865                 870                       

gta aca ggt ctt cgc tgt aat cag tgt gag cct cac agg tac aat ttg       3054
Val Thr Gly Leu Arg Cys Asn Gln Cys Glu Pro His Arg Tyr Asn Leu           
    875                 880                 885                           

acc att gac aat ttt caa cac tgc cag atg tgt gag tgt gat tcc ttg       3102
Thr Ile Asp Asn Phe Gln His Cys Gln Met Cys Glu Cys Asp Ser Leu           
890                 895                 900                 905           

ggg aca tta cct ggg acc att tgt gac cca atc agt ggc cag tgc ctg       3150
Gly Thr Leu Pro Gly Thr Ile Cys Asp Pro Ile Ser Gly Gln Cys Leu           
                910                 915                 920               

tgt gtg cct aat cgt caa gga aga agg tgt aat cag tgt caa cca ggt       3198
Cys Val Pro Asn Arg Gln Gly Arg Arg Cys Asn Gln Cys Gln Pro Gly           
            925                 930                 935                   

ttt tat att tct cca ggc aat gcc act ggc tgc ctg cca tgc tca tgc       3246
Phe Tyr Ile Ser Pro Gly Asn Ala Thr Gly Cys Leu Pro Cys Ser Cys           
        940                 945                 950                       

cat aca act ggt gca gtt aat cac atc tgt aat agc ctg act ggt cag       3294
His Thr Thr Gly Ala Val Asn His Ile Cys Asn Ser Leu Thr Gly Gln           
    955                 960                 965                           

tgt gtt tgc caa gat gct tcc att gct ggg caa cgt tgt gac caa tgc       3342
Cys Val Cys Gln Asp Ala Ser Ile Ala Gly Gln Arg Cys Asp Gln Cys           
970                 975                 980                 985           

aaa gac cat tac ttt gga ttt gat cct cag act gga aga tgt cag  cct      3390
Lys Asp His Tyr Phe Gly Phe Asp Pro Gln Thr Gly Arg Cys Gln  Pro          
                990                 995                 1000              

tgt aat tgt cat  ctc tca gga gcc ttg  aat gaa acc tgt cac  ttg        3435
Cys Asn Cys His  Leu Ser Gly Ala Leu  Asn Glu Thr Cys His  Leu            
            1005                 1010                 1015                

gtc aca ggc cag  tgt ttc tgt aaa caa  ttt gtc act ggc tca  aag        3480
Val Thr Gly Gln  Cys Phe Cys Lys Gln  Phe Val Thr Gly Ser  Lys            
            1020                 1025                 1030                

tgt gat gct tgt  gtt ccc agt gca agc  cac ttg gat gtc aac  aat        3525
Cys Asp Ala Cys  Val Pro Ser Ala Ser  His Leu Asp Val Asn  Asn            
            1035                 1040                 1045                

cta ttg ggt tgc  agc aaa act cca ttc  cag caa cct ccg ccc  aga        3570
Leu Leu Gly Cys  Ser Lys Thr Pro Phe  Gln Gln Pro Pro Pro  Arg            
            1050                 1055                 1060                

gga caa gtt caa  agt tct tct gct atc  aat ctc tcc tgg agt  cca        3615
Gly Gln Val Gln  Ser Ser Ser Ala Ile  Asn Leu Ser Trp Ser  Pro            
            1065                 1070                 1075                

cct gat tct cca  aat gcc cac tgg ctt  act tac agt tta ctc  agg        3660
Pro Asp Ser Pro  Asn Ala His Trp Leu  Thr Tyr Ser Leu Leu  Arg            
            1080                 1085                 1090                

gat ggt ttt gaa  atc tac aca aca gag  gat caa tac cca tac  agt        3705
Asp Gly Phe Glu  Ile Tyr Thr Thr Glu  Asp Gln Tyr Pro Tyr  Ser            
            1095                 1100                 1105                

att caa tac ttc  tta gac aca gac ctg  tta cca tat acc aaa  tat        3750
Ile Gln Tyr Phe  Leu Asp Thr Asp Leu  Leu Pro Tyr Thr Lys  Tyr            
            1110                 1115                 1120                

tcc tat tac att  gag acc acc aat gtg  cat ggt tca aca agg  agt        3795
Ser Tyr Tyr Ile  Glu Thr Thr Asn Val  His Gly Ser Thr Arg  Ser            
            1125                 1130                 1135                

gta gct gtc act  tac aag aca aaa cca  ggg gtc cca gag gga  aac        3840
Val Ala Val Thr  Tyr Lys Thr Lys Pro  Gly Val Pro Glu Gly  Asn            
            1140                 1145                 1150                

ttg act tta agt  tat atc att cct att  ggc tca gac tct gtg  aca        3885
Leu Thr Leu Ser  Tyr Ile Ile Pro Ile  Gly Ser Asp Ser Val  Thr            
            1155                 1160                 1165                

ctt acc tgg aca  aca ctc tca aat caa  tct ggt ccc ata gag  aaa        3930
Leu Thr Trp Thr  Thr Leu Ser Asn Gln  Ser Gly Pro Ile Glu  Lys            
            1170                 1175                 1180                

tat att ttg tcc  tgt gcc cct ttg gct  ggt ggt cag cca tgt  gtt        3975
Tyr Ile Leu Ser  Cys Ala Pro Leu Ala  Gly Gly Gln Pro Cys  Val            
            1185                 1190                 1195                

tcc tac gaa ggt  cat gaa acc tca gct  acc atc tgg aat ctg  gtt        4020
Ser Tyr Glu Gly  His Glu Thr Ser Ala  Thr Ile Trp Asn Leu  Val            
            1200                 1205                 1210                

cca ttt gcc aag  tac gat ttt tct gta  cag gcg tgt act agc  ggg        4065
Pro Phe Ala Lys  Tyr Asp Phe Ser Val  Gln Ala Cys Thr Ser  Gly            
            1215                 1220                 1225                

ggc tgt tta cac  agc ttg ccc att aca  gtg acc aca gcc cag  gcc        4110
Gly Cys Leu His  Ser Leu Pro Ile Thr  Val Thr Thr Ala Gln  Ala            
            1230                 1235                 1240                

cct ccc caa aga  cta agt cca cct aag  atg cag aaa atc agt  tct        4155
Pro Pro Gln Arg  Leu Ser Pro Pro Lys  Met Gln Lys Ile Ser  Ser            
            1245                 1250                 1255                

aca gaa ctt cat  gta gaa tgg tct cca  cca gcg gaa cta aat  gga        4200
Thr Glu Leu His  Val Glu Trp Ser Pro  Pro Ala Glu Leu Asn  Gly            
            1260                 1265                 1270                

ata att ata aga  tat gaa cta tac atg  aga aga ctg aga tct  act        4245
Ile Ile Ile Arg  Tyr Glu Leu Tyr Met  Arg Arg Leu Arg Ser  Thr            
            1275                 1280                 1285                

aaa gaa acc aca  tct gag gaa agt cga  gtt ttt cag agc agt  ggt        4290
Lys Glu Thr Thr  Ser Glu Glu Ser Arg  Val Phe Gln Ser Ser  Gly            
            1290                 1295                 1300                

tgg ctc agt cct  cat tca ttt gta gaa  tcg gcc aat gaa aat  gca        4335
Trp Leu Ser Pro  His Ser Phe Val Glu  Ser Ala Asn Glu Asn  Ala            
            1305                 1310                 1315                

tta aaa cct cct  caa aca atg aca acc  atc act ggc ttg gag  cca        4380
Leu Lys Pro Pro  Gln Thr Met Thr Thr  Ile Thr Gly Leu Glu  Pro            
            1320                 1325                 1330                

tac acc aag tat  gag ttc aga gtc tta  gct gtg aat atg gct  gga        4425
Tyr Thr Lys Tyr  Glu Phe Arg Val Leu  Ala Val Asn Met Ala  Gly            
            1335                 1340                 1345                

agt gtg tct tct  gcc tgg gtc tca gaa  aga acg gga gaa tca  gca        4470
Ser Val Ser Ser  Ala Trp Val Ser Glu  Arg Thr Gly Glu Ser  Ala            
            1350                 1355                 1360                

cct gta ttc atg  atc cct cct tca gtc  ttt ccc ctc tct tcg  tac        4515
Pro Val Phe Met  Ile Pro Pro Ser Val  Phe Pro Leu Ser Ser  Tyr            
            1365                 1370                 1375                

tct ctc aat atc  tcc tgg gag aag cca  gca gat aat gtt aca  aga        4560
Ser Leu Asn Ile  Ser Trp Glu Lys Pro  Ala Asp Asn Val Thr  Arg            
            1380                 1385                 1390                

gga aaa gtt gtg  ggg tat gac atc aat  atg ctt tct gaa caa  tca        4605
Gly Lys Val Val  Gly Tyr Asp Ile Asn  Met Leu Ser Glu Gln  Ser            
            1395                 1400                 1405                

cct caa cag tct  att ccc atg gcg ttt  tca cag ctg ttg cac  act        4650
Pro Gln Gln Ser  Ile Pro Met Ala Phe  Ser Gln Leu Leu His  Thr            
            1410                 1415                 1420                

gct aaa tcc caa  gaa cta tct tac act  gta gaa gga ctg aaa  cct        4695
Ala Lys Ser Gln  Glu Leu Ser Tyr Thr  Val Glu Gly Leu Lys  Pro            
            1425                 1430                 1435                

tat agg ata tat  gag ttt act att act  ctc tgc aat tca gtt  ggt        4740
Tyr Arg Ile Tyr  Glu Phe Thr Ile Thr  Leu Cys Asn Ser Val  Gly            
            1440                 1445                 1450                

tgt gtg acc agt  gct tcg gga gca gga  caa act tta gca gca  gca        4785
Cys Val Thr Ser  Ala Ser Gly Ala Gly  Gln Thr Leu Ala Ala  Ala            
            1455                 1460                 1465                

cca gca caa ctg  agg cca cct ctg gtt  aaa gga atc aac agc  aca        4830
Pro Ala Gln Leu  Arg Pro Pro Leu Val  Lys Gly Ile Asn Ser  Thr            
            1470                 1475                 1480                

aca atc cat ctt  aag tgg ttt cca cct  gaa gaa ctg aat gga  ccc        4875
Thr Ile His Leu  Lys Trp Phe Pro Pro  Glu Glu Leu Asn Gly  Pro            
            1485                 1490                 1495                

tct cct ata tat  cag ctg gaa agg aga  gag tca tct cta cca  gct        4920
Ser Pro Ile Tyr  Gln Leu Glu Arg Arg  Glu Ser Ser Leu Pro  Ala            
            1500                 1505                 1510                

ctg atg acc acg  atg atg aaa gga atc  cgt ttc ata gga aat  ggg        4965
Leu Met Thr Thr  Met Met Lys Gly Ile  Arg Phe Ile Gly Asn  Gly            
            1515                 1520                 1525                

tat tgt aaa ttt  ccc agc tcc act cac  cca gtc aat aca gac  ttc        5010
Tyr Cys Lys Phe  Pro Ser Ser Thr His  Pro Val Asn Thr Asp  Phe            
            1530                 1535                 1540                

act ggc att aag  gcc agc ttt cga aca  aaa gtg cct gaa ggt  ttg        5055
Thr Gly Ile Lys  Ala Ser Phe Arg Thr  Lys Val Pro Glu Gly  Leu            
            1545                 1550                 1555                

att gtc ttt gca  gca tca cct ggc aat  cag gaa gag tat ttt  gca        5100
Ile Val Phe Ala  Ala Ser Pro Gly Asn  Gln Glu Glu Tyr Phe  Ala            
            1560                 1565                 1570                

ctt cag ttg aag  aag gga cgt ctt tat  ttt ctt ttt gat cct  cag        5145
Leu Gln Leu Lys  Lys Gly Arg Leu Tyr  Phe Leu Phe Asp Pro  Gln            
            1575                 1580                 1585                

ggg tca cca gtg  gaa gta act aca act  aat gat cat ggc aaa  caa        5190
Gly Ser Pro Val  Glu Val Thr Thr Thr  Asn Asp His Gly Lys  Gln            
            1590                 1595                 1600                

tat agt gat gga  aaa tgg cat gaa ata  att gct att agg cat  cag        5235
Tyr Ser Asp Gly  Lys Trp His Glu Ile  Ile Ala Ile Arg His  Gln            
            1605                 1610                 1615                

gct ttt ggc caa  atc act ctg gat ggg  ata tat aca ggt tcc  tct        5280
Ala Phe Gly Gln  Ile Thr Leu Asp Gly  Ile Tyr Thr Gly Ser  Ser            
            1620                 1625                 1630                

gcc atc ctg aat  ggt agt act gtt att  gga gat aac aca gga  gtc        5325
Ala Ile Leu Asn  Gly Ser Thr Val Ile  Gly Asp Asn Thr Gly  Val            
            1635                 1640                 1645                

ttt ctg gga ggg  ctc ccg cga agt tat  acc atc ctc agg aag  gat        5370
Phe Leu Gly Gly  Leu Pro Arg Ser Tyr  Thr Ile Leu Arg Lys  Asp            
            1650                 1655                 1660                

cct gag ata atc  caa aaa ggt ttt gtg  ggc tgt ctc aag gat  gta        5415
Pro Glu Ile Ile  Gln Lys Gly Phe Val  Gly Cys Leu Lys Asp  Val            
            1665                 1670                 1675                

cat ttt atg aag  aat tac aat ccg tca  gct att tgg gaa cct  ctg        5460
His Phe Met Lys  Asn Tyr Asn Pro Ser  Ala Ile Trp Glu Pro  Leu            
            1680                 1685                 1690                

gat tgg cag agt  tct gaa gaa caa atc  aac gtg tat aac agc  tgg        5505
Asp Trp Gln Ser  Ser Glu Glu Gln Ile  Asn Val Tyr Asn Ser  Trp            
            1695                 1700                 1705                

gag gga tgt ccc  gct tca tta aat gag  gga gct cag ttc cta  gga        5550
Glu Gly Cys Pro  Ala Ser Leu Asn Glu  Gly Ala Gln Phe Leu  Gly            
            1710                 1715                 1720                

gca ggg ttc ctg  gaa ctt cat cca tat  atg ttt cat ggt gga  atg        5595
Ala Gly Phe Leu  Glu Leu His Pro Tyr  Met Phe His Gly Gly  Met            
            1725                 1730                 1735                

aac ttt gag att  tcc ttt aag ttc aga  act gac caa tta aat  gga        5640
Asn Phe Glu Ile  Ser Phe Lys Phe Arg  Thr Asp Gln Leu Asn  Gly            
            1740                 1745                 1750                

ttg ctt ctt ttc  gtt tat aac aaa gat  gga cct gat ttt ctt  gct        5685
Leu Leu Leu Phe  Val Tyr Asn Lys Asp  Gly Pro Asp Phe Leu  Ala            
            1755                 1760                 1765                

atg gag ctg aaa  agt gga ata ttg acc  ttc cgg tta aat acc  agt        5730
Met Glu Leu Lys  Ser Gly Ile Leu Thr  Phe Arg Leu Asn Thr  Ser            
            1770                 1775                 1780                

ctt gcc ttt aca  caa gtg gat cta ttg  ctg ggg cta tcc tat  tgt        5775
Leu Ala Phe Thr  Gln Val Asp Leu Leu  Leu Gly Leu Ser Tyr  Cys            
            1785                 1790                 1795                

aat gga aag tgg  aat aaa gtc att att  aaa aag gaa ggc tct  ttc        5820
Asn Gly Lys Trp  Asn Lys Val Ile Ile  Lys Lys Glu Gly Ser  Phe            
            1800                 1805                 1810                

ata tca gca agt  gtg aat gga ctg atg  aag cat gca tcg gag  tcc        5865
Ile Ser Ala Ser  Val Asn Gly Leu Met  Lys His Ala Ser Glu  Ser            
            1815                 1820                 1825                

gga gac cag cca  ctg gtg gtg aat tca  cca gtt tat gtg gga  gga        5910
Gly Asp Gln Pro  Leu Val Val Asn Ser  Pro Val Tyr Val Gly  Gly            
            1830                 1835                 1840                

atc cca cag gaa  ctg ctg aac tct tat  caa cat ttg tgt ttg  gaa        5955
Ile Pro Gln Glu  Leu Leu Asn Ser Tyr  Gln His Leu Cys Leu  Glu            
            1845                 1850                 1855                

caa ggt ttc ggt  ggt tgc atg aag gat  gtt aaa ttt aca cgg  ggt        6000
Gln Gly Phe Gly  Gly Cys Met Lys Asp  Val Lys Phe Thr Arg  Gly            
            1860                 1865                 1870                

gct gtc gtt aac  ttg gca tct gtg tcc  agc ggt gct gtc aga  gtc        6045
Ala Val Val Asn  Leu Ala Ser Val Ser  Ser Gly Ala Val Arg  Val            
            1875                 1880                 1885                

aat ctg gat gga  tgc cta tca act gac  agt gct gtt aac tgc  agg        6090
Asn Leu Asp Gly  Cys Leu Ser Thr Asp  Ser Ala Val Asn Cys  Arg            
            1890                 1895                 1900                

gga aat gac tcc  atc ctg gtt tac cag  gga aaa gag cag agt  gtt        6135
Gly Asn Asp Ser  Ile Leu Val Tyr Gln  Gly Lys Glu Gln Ser  Val            
            1905                 1910                 1915                

tac gag ggt ggt  ctc cag cct ttt aca  gaa tac ctg tat cga  gtg        6180
Tyr Glu Gly Gly  Leu Gln Pro Phe Thr  Glu Tyr Leu Tyr Arg  Val            
            1920                 1925                 1930                

ata gcc tcg cat  gaa gga ggt tca gta  tat agt gat tgg agt  cga        6225
Ile Ala Ser His  Glu Gly Gly Ser Val  Tyr Ser Asp Trp Ser  Arg            
            1935                 1940                 1945                

gga cgt aca aca  gga gca gct cca caa  agt gtg cca act ccc  tca        6270
Gly Arg Thr Thr  Gly Ala Ala Pro Gln  Ser Val Pro Thr Pro  Ser            
            1950                 1955                 1960                

aga gtc cgc agc  tta aat gga tac agc  att gag gtg acc tgg  gat        6315
Arg Val Arg Ser  Leu Asn Gly Tyr Ser  Ile Glu Val Thr Trp  Asp            
            1965                 1970                 1975                

gaa cct gtt gtc  aga ggt gta att gag  aag tac att ctg aaa  gcc        6360
Glu Pro Val Val  Arg Gly Val Ile Glu  Lys Tyr Ile Leu Lys  Ala            
            1980                 1985                 1990                

tat agt gag gac  agc acc cgt cca ccc  cgc atg ccc tct gcc  agt        6405
Tyr Ser Glu Asp  Ser Thr Arg Pro Pro  Arg Met Pro Ser Ala  Ser            
            1995                 2000                 2005                

gct gaa ttt gtc  aat aca agc aac ctc  aca ggc ata ttg aca  ggc        6450
Ala Glu Phe Val  Asn Thr Ser Asn Leu  Thr Gly Ile Leu Thr  Gly            
            2010                 2015                 2020                

ttg cta ccc ttc  aaa aac tat gca gta  acc cta act gct tgc  act        6495
Leu Leu Pro Phe  Lys Asn Tyr Ala Val  Thr Leu Thr Ala Cys  Thr            
            2025                 2030                 2035                

ttg gct ggc tgt  act gag agc tca cat  gca ttg aac atc tct  act        6540
Leu Ala Gly Cys  Thr Glu Ser Ser His  Ala Leu Asn Ile Ser  Thr            
            2040                 2045                 2050                

cca caa gaa gcc  cca caa gag gtt cag  cca cca gta gcc aaa  tcc        6585
Pro Gln Glu Ala  Pro Gln Glu Val Gln  Pro Pro Val Ala Lys  Ser            
            2055                 2060                 2065                

ctt ccc agt tct  ttg ctg ctc tcc tgg  aac cca ccc aaa aag  gca        6630
Leu Pro Ser Ser  Leu Leu Leu Ser Trp  Asn Pro Pro Lys Lys  Ala            
            2070                 2075                 2080                

aat ggt att ata  act cag tac tgt tta  tac atg gat ggg agg  ctg        6675
Asn Gly Ile Ile  Thr Gln Tyr Cys Leu  Tyr Met Asp Gly Arg  Leu            
            2085                 2090                 2095                

atc tat tca ggc  agt gag gag aac tac  aca gtc aca gat tta  gca        6720
Ile Tyr Ser Gly  Ser Glu Glu Asn Tyr  Thr Val Thr Asp Leu  Ala            
            2100                 2105                 2110                

gta ttt aca ccc  cac cag ttt cta cta  agt gca tgc aca cat  gtg        6765
Val Phe Thr Pro  His Gln Phe Leu Leu  Ser Ala Cys Thr His  Val            
            2115                 2120                 2125                

ggc tgt aca aac  agt tcc tgg gtc cta  ctg tac aca gca cag  ctg        6810
Gly Cys Thr Asn  Ser Ser Trp Val Leu  Leu Tyr Thr Ala Gln  Leu            
            2130                 2135                 2140                

cca cca gaa cac  gtg gat tcc cca gtt  ctg act gtc ctg gat  tct        6855
Pro Pro Glu His  Val Asp Ser Pro Val  Leu Thr Val Leu Asp  Ser            
            2145                 2150                 2155                

aga act ata cac  ata cag tgg aaa caa  cca aga aaa ata agt  ggg        6900
Arg Thr Ile His  Ile Gln Trp Lys Gln  Pro Arg Lys Ile Ser  Gly            
            2160                 2165                 2170                

att ctg gaa cgc  tat gta tta tat atg  tca aac cat aca cat  gat        6945
Ile Leu Glu Arg  Tyr Val Leu Tyr Met  Ser Asn His Thr His  Asp            
            2175                 2180                 2185                

ttt aca att tgg  agt gtc atc tat aac  agt aca gaa ctt ttc  cag        6990
Phe Thr Ile Trp  Ser Val Ile Tyr Asn  Ser Thr Glu Leu Phe  Gln            
            2190                 2195                 2200                

gat cat atg cta  caa tac gtt tta cct  ggt aat aaa tat ctc  atc        7035
Asp His Met Leu  Gln Tyr Val Leu Pro  Gly Asn Lys Tyr Leu  Ile            
            2205                 2210                 2215                

aag ctg gga gct  tgc aca ggt ggt ggg  tgc aca gtg agt gag  gcc        7080
Lys Leu Gly Ala  Cys Thr Gly Gly Gly  Cys Thr Val Ser Glu  Ala            
            2220                 2225                 2230                

agt gag gcc cta  act gac gag gac ata  ccc gaa ggc gtg cca  gcc        7125
Ser Glu Ala Leu  Thr Asp Glu Asp Ile  Pro Glu Gly Val Pro  Ala            
            2235                 2240                 2245                

ccc aaa gcc cac  tca tat tca cct gac  tcc ttt aat gtc tcc  tgg        7170
Pro Lys Ala His  Ser Tyr Ser Pro Asp  Ser Phe Asn Val Ser  Trp            
            2250                 2255                 2260                

act gag cct gaa  tat ccg aat ggt gtt  atc acg agt tat gga  tta        7215
Thr Glu Pro Glu  Tyr Pro Asn Gly Val  Ile Thr Ser Tyr Gly  Leu            
            2265                 2270                 2275                

tat cta gat ggt  ata tta atc cac aat  tcc tca gaa ctc agc  tat        7260
Tyr Leu Asp Gly  Ile Leu Ile His Asn  Ser Ser Glu Leu Ser  Tyr            
            2280                 2285                 2290                

cgt gct tac gga  ttt gct cct tgg agt  tta cat tcc ttc aga  gtc        7305
Arg Ala Tyr Gly  Phe Ala Pro Trp Ser  Leu His Ser Phe Arg  Val            
            2295                 2300                 2305                

caa gca tgc acg  gcc aaa ggt tgt gct  ctg ggc cca ctg gtg  gaa        7350
Gln Ala Cys Thr  Ala Lys Gly Cys Ala  Leu Gly Pro Leu Val  Glu            
            2310                 2315                 2320                

aat cga act cta  gaa gct cct cct gaa  gga aca gta aat gtg  ttt        7395
Asn Arg Thr Leu  Glu Ala Pro Pro Glu  Gly Thr Val Asn Val  Phe            
            2325                 2330                 2335                

gtc aaa aca cag  gga tcc cgg aaa gcc  cac gtg agg tgg gaa  gca        7440
Val Lys Thr Gln  Gly Ser Arg Lys Ala  His Val Arg Trp Glu  Ala            
            2340                 2345                 2350                

cct ttt cgc cct  aat gga ctc tta aca  cac tca gtc ctt ttc  act        7485
Pro Phe Arg Pro  Asn Gly Leu Leu Thr  His Ser Val Leu Phe  Thr            
            2355                 2360                 2365                

ggg ata ttc tat  gta gac cca gta ggt  aat aac tac acc ctt  ctg        7530
Gly Ile Phe Tyr  Val Asp Pro Val Gly  Asn Asn Tyr Thr Leu  Leu            
            2370                 2375                 2380                

aat gtc aca aaa  gtc atg tac agc gga  gaa gag aca aac ctt  tgg        7575
Asn Val Thr Lys  Val Met Tyr Ser Gly  Glu Glu Thr Asn Leu  Trp            
            2385                 2390                 2395                

gtg ctc atc gat  ggg ctg gtt cct ttt  acc aac tat act gta  caa        7620
Val Leu Ile Asp  Gly Leu Val Pro Phe  Thr Asn Tyr Thr Val  Gln            
            2400                 2405                 2410                

gtg aat att tca  aat agc caa ggc agc  ttg ata act gat cct  ata        7665
Val Asn Ile Ser  Asn Ser Gln Gly Ser  Leu Ile Thr Asp Pro  Ile            
            2415                 2420                 2425                

aca att gca atg  cct cca gga gct cca  gat ggc gtg ctg cct  ccc        7710
Thr Ile Ala Met  Pro Pro Gly Ala Pro  Asp Gly Val Leu Pro  Pro            
            2430                 2435                 2440                

agg ctt tca tct  gcc act cca acc agt  ctt cag gtt gtc tgg  tct        7755
Arg Leu Ser Ser  Ala Thr Pro Thr Ser  Leu Gln Val Val Trp  Ser            
            2445                 2450                 2455                

aca cca gct cgt  aat aac gct cct ggc  tct ccc aga tac caa  ctc        7800
Thr Pro Ala Arg  Asn Asn Ala Pro Gly  Ser Pro Arg Tyr Gln  Leu            
            2460                 2465                 2470                

cag atg agg tct  ggc gac tcc acc cat  gga ttt cta gag tta  ttt        7845
Gln Met Arg Ser  Gly Asp Ser Thr His  Gly Phe Leu Glu Leu  Phe            
            2475                 2480                 2485                

tcc aat cct tct  gca tcg tta agc tat  gaa gtg agt gat ctc  caa        7890
Ser Asn Pro Ser  Ala Ser Leu Ser Tyr  Glu Val Ser Asp Leu  Gln            
            2490                 2495                 2500                

ccg tac aca gag  tat atg ttt cgg ttg  gtt gcc tcc aat gga  ttt        7935
Pro Tyr Thr Glu  Tyr Met Phe Arg Leu  Val Ala Ser Asn Gly  Phe            
            2505                 2510                 2515                

ggc agt gca cat  agt tct tgg att cca  ttc atg acc gca gag  gac        7980
Gly Ser Ala His  Ser Ser Trp Ile Pro  Phe Met Thr Ala Glu  Asp            
            2520                 2525                 2530                

aaa cct gga cct  gta gtt cct ccg att  ctt ctg gat gtg aag  tca        8025
Lys Pro Gly Pro  Val Val Pro Pro Ile  Leu Leu Asp Val Lys  Ser            
            2535                 2540                 2545                

aga atg atg ttg  gtc acc tgg cag cat  cct aga aaa tcc aat  ggg        8070
Arg Met Met Leu  Val Thr Trp Gln His  Pro Arg Lys Ser Asn  Gly            
            2550                 2555                 2560                

gtt att acc cat  tat aac att tat cta  cat ggc cgt cta tac  ttg        8115
Val Ile Thr His  Tyr Asn Ile Tyr Leu  His Gly Arg Leu Tyr  Leu            
            2565                 2570                 2575                

aga act cct gga  aat gtc act aat tgc  aca gtg atg cat tta  cac        8160
Arg Thr Pro Gly  Asn Val Thr Asn Cys  Thr Val Met His Leu  His            
            2580                 2585                 2590                

cca tac act gcc  tat aag ttt cag gta  gaa gcc tgc act tca  aaa        8205
Pro Tyr Thr Ala  Tyr Lys Phe Gln Val  Glu Ala Cys Thr Ser  Lys            
            2595                 2600                 2605                

gga tgt tcc ctt  tca cca gag tcc cag  act gta tgg aca ctc  cca        8250
Gly Cys Ser Leu  Ser Pro Glu Ser Gln  Thr Val Trp Thr Leu  Pro            
            2610                 2615                 2620                

ggg gca ccg gaa  ggg atc cca agt cca  gag ctg ttc tct gat  act        8295
Gly Ala Pro Glu  Gly Ile Pro Ser Pro  Glu Leu Phe Ser Asp  Thr            
            2625                 2630                 2635                

cca aca tct gtg  att ata tct tgg caa  ccc cct acc cac ccc  aat        8340
Pro Thr Ser Val  Ile Ile Ser Trp Gln  Pro Pro Thr His Pro  Asn            
            2640                 2645                 2650                

ggc ttg gtg gag  aat ttc aca att gag  aga aga gtc aaa gga  aag        8385
Gly Leu Val Glu  Asn Phe Thr Ile Glu  Arg Arg Val Lys Gly  Lys            
            2655                 2660                 2665                

gaa gaa gtt act  acc ctg gtg act ctc  ccg agg agt cat tcc  atg        8430
Glu Glu Val Thr  Thr Leu Val Thr Leu  Pro Arg Ser His Ser  Met            
            2670                 2675                 2680                

agg ttt att gac  aag act tct gct ctt  agc cca tgg aca aaa  tat        8475
Arg Phe Ile Asp  Lys Thr Ser Ala Leu  Ser Pro Trp Thr Lys  Tyr            
            2685                 2690                 2695                

gaa tat cgg gta  ctg atg agc act ctt  cat gga ggc aca aac  agc        8520
Glu Tyr Arg Val  Leu Met Ser Thr Leu  His Gly Gly Thr Asn  Ser            
            2700                 2705                 2710                

agt gct tgg gta  gaa gtt acc aca aga  ccc tca cga cct gct  ggg        8565
Ser Ala Trp Val  Glu Val Thr Thr Arg  Pro Ser Arg Pro Ala  Gly            
            2715                 2720                 2725                

gtg cag cca cct  gtg gtg aca gtg ctg  gaa ccc gat gca gtc  cag        8610
Val Gln Pro Pro  Val Val Thr Val Leu  Glu Pro Asp Ala Val  Gln            
            2730                 2735                 2740                

gtc act tgg aaa  ccc cca ctc atc cag  aac gga gac ata ctt  agc        8655
Val Thr Trp Lys  Pro Pro Leu Ile Gln  Asn Gly Asp Ile Leu  Ser            
            2745                 2750                 2755                

tat gag att cac  atg cct gac cct cac  atc act tta acc aat  gtg        8700
Tyr Glu Ile His  Met Pro Asp Pro His  Ile Thr Leu Thr Asn  Val            
            2760                 2765                 2770                

act tcc gca gtg  tta agt caa aaa gtt  act cat ctg att cct  ttc        8745
Thr Ser Ala Val  Leu Ser Gln Lys Val  Thr His Leu Ile Pro  Phe            
            2775                 2780                 2785                

act aat tat tct  gtc acc att gtt gct  tgc tca ggg ggt aat  ggg        8790
Thr Asn Tyr Ser  Val Thr Ile Val Ala  Cys Ser Gly Gly Asn  Gly            
            2790                 2795                 2800                

tac ctt gga ggg  tgc aca gag agt tta  cct acc tat gtt acc  act        8835
Tyr Leu Gly Gly  Cys Thr Glu Ser Leu  Pro Thr Tyr Val Thr  Thr            
            2805                 2810                 2815                

cac ccc acc gta  cct cag aat gtt ggc  cca ttg tct gtg att  cca        8880
His Pro Thr Val  Pro Gln Asn Val Gly  Pro Leu Ser Val Ile  Pro            
            2820                 2825                 2830                

cta agt gaa tca  tat gtt gtg att tct  tgg caa cca cca tcc  aag        8925
Leu Ser Glu Ser  Tyr Val Val Ile Ser  Trp Gln Pro Pro Ser  Lys            
            2835                 2840                 2845                

cca aat gga cct  aat ttg aga tat gag  ctt ctg aga cgt aaa  atc        8970
Pro Asn Gly Pro  Asn Leu Arg Tyr Glu  Leu Leu Arg Arg Lys  Ile            
            2850                 2855                 2860                

cag cag cca ctt  gca tca aat ccc cca  gaa gat tta aat cgg  tgg        9015
Gln Gln Pro Leu  Ala Ser Asn Pro Pro  Glu Asp Leu Asn Arg  Trp            
            2865                 2870                 2875                

cac aat att tat  tca gga act cag tgg  ctt tat gaa gat aag  ggt        9060
His Asn Ile Tyr  Ser Gly Thr Gln Trp  Leu Tyr Glu Asp Lys  Gly            
            2880                 2885                 2890                

ctt agc agg ttt  aca acc tat gaa tat  atg ctc ttc gta cac  aac        9105
Leu Ser Arg Phe  Thr Thr Tyr Glu Tyr  Met Leu Phe Val His  Asn            
            2895                 2900                 2905                

agt gtg ggt ttt  aca ccg agc cga gaa  gtg act gtg aca acg  tta        9150
Ser Val Gly Phe  Thr Pro Ser Arg Glu  Val Thr Val Thr Thr  Leu            
            2910                 2915                 2920                

gct ggt ctt cca  gag aga gga gcc aat  ctc act gcg agt gtc  ctt        9195
Ala Gly Leu Pro  Glu Arg Gly Ala Asn  Leu Thr Ala Ser Val  Leu            
            2925                 2930                 2935                

aac cac aca gcc  atc gac gtg agg tgg  gct aaa cca act gtt  caa        9240
Asn His Thr Ala  Ile Asp Val Arg Trp  Ala Lys Pro Thr Val  Gln            
            2940                 2945                 2950                

gac cta caa ggt  gaa gtt gaa tat tac  aca ctt ttt tgg agt  tct        9285
Asp Leu Gln Gly  Glu Val Glu Tyr Tyr  Thr Leu Phe Trp Ser  Ser            
            2955                 2960                 2965                

gct acc tca aac  gac tct cta aaa atc  ttg cca gat gta aac  tct        9330
Ala Thr Ser Asn  Asp Ser Leu Lys Ile  Leu Pro Asp Val Asn  Ser            
            2970                 2975                 2980                

cat gtc att ggc  cac cta aag cca aac  aca gag tat tgg atc  ttt        9375
His Val Ile Gly  His Leu Lys Pro Asn  Thr Glu Tyr Trp Ile  Phe            
            2985                 2990                 2995                

atc tct gtc ttc  aat gga gtc cac agc  atc aac agt gca gga  ctt        9420
Ile Ser Val Phe  Asn Gly Val His Ser  Ile Asn Ser Ala Gly  Leu            
            3000                 3005                 3010                

cat gca acc act  tgc gat ggg gag cct  cag ggc atg ctt cct  cca        9465
His Ala Thr Thr  Cys Asp Gly Glu Pro  Gln Gly Met Leu Pro  Pro            
            3015                 3020                 3025                

gag gtt gtc atc  atc aac agt aca gct  gta cgt gtc atc tgg  aca        9510
Glu Val Val Ile  Ile Asn Ser Thr Ala  Val Arg Val Ile Trp  Thr            
            3030                 3035                 3040                

tct cct tca aac  cca aat ggt gtt gtc  act gag tat tct atc  tat        9555
Ser Pro Ser Asn  Pro Asn Gly Val Val  Thr Glu Tyr Ser Ile  Tyr            
            3045                 3050                 3055                

gta aat aat aag  ctc tac aag act gga  atg aat gtg cct ggg  tcg        9600
Val Asn Asn Lys  Leu Tyr Lys Thr Gly  Met Asn Val Pro Gly  Ser            
            3060                 3065                 3070                

ttt att ctg aga  gac ctg tct ccc ttc  act atc tat gac att  cag        9645
Phe Ile Leu Arg  Asp Leu Ser Pro Phe  Thr Ile Tyr Asp Ile  Gln            
            3075                 3080                 3085                

gtt gaa gtc tgc  aca ata tat gcc tgc  gtg aaa agc aat gga  acc        9690
Val Glu Val Cys  Thr Ile Tyr Ala Cys  Val Lys Ser Asn Gly  Thr            
            3090                 3095                 3100                

caa att acc act  gtg gaa gac act cca  agt gat ata cca aca  ccc        9735
Gln Ile Thr Thr  Val Glu Asp Thr Pro  Ser Asp Ile Pro Thr  Pro            
            3105                 3110                 3115                

aca att cgt ggc  atc act tca aga tct  ctt caa att gat tgg  gtg        9780
Thr Ile Arg Gly  Ile Thr Ser Arg Ser  Leu Gln Ile Asp Trp  Val            
            3120                 3125                 3130                

tct cca cgg aag  cca aat ggc atc att  ctt gga tat gat ctc  cta        9825
Ser Pro Arg Lys  Pro Asn Gly Ile Ile  Leu Gly Tyr Asp Leu  Leu            
            3135                 3140                 3145                

tgg aaa aca tgg  tat cca tgc gct aaa  act caa aag tta gtg  cag        9870
Trp Lys Thr Trp  Tyr Pro Cys Ala Lys  Thr Gln Lys Leu Val  Gln            
            3150                 3155                 3160                

gat cag agt gat  gag ctc tgc aag gca  gtg agg tgt caa aaa  cct        9915
Asp Gln Ser Asp  Glu Leu Cys Lys Ala  Val Arg Cys Gln Lys  Pro            
            3165                 3170                 3175                

gaa tct atc tgt  gga cac att tgc tat  tct tct gaa gct aag  gtt        9960
Glu Ser Ile Cys  Gly His Ile Cys Tyr  Ser Ser Glu Ala Lys  Val            
            3180                 3185                 3190                

tgt tgt aac gga  gtg ctc tat aac ccc  aag cct gga cat cgc  tgt       10005
Cys Cys Asn Gly  Val Leu Tyr Asn Pro  Lys Pro Gly His Arg  Cys            
            3195                 3200                 3205                

tgt gaa gaa aag  tat atc ccg ttt gtt  ctg aat tct act gga  gtt       10050
Cys Glu Glu Lys  Tyr Ile Pro Phe Val  Leu Asn Ser Thr Gly  Val            
            3210                 3215                 3220                

tgt tgt ggt ggc  cga ata cag gag gca  caa cca aat cat cag  tgc       10095
Cys Cys Gly Gly  Arg Ile Gln Glu Ala  Gln Pro Asn His Gln  Cys            
            3225                 3230                 3235                

tgc tct ggg tat  tac gct aga att cta  cca ggt gaa gta tgc  tgt       10140
Cys Ser Gly Tyr  Tyr Ala Arg Ile Leu  Pro Gly Glu Val Cys  Cys            
            3240                 3245                 3250                

cca gat gaa cag  cac aat cgg gtt tct  gtt ggc att ggt gat  tcc       10185
Pro Asp Glu Gln  His Asn Arg Val Ser  Val Gly Ile Gly Asp  Ser            
            3255                 3260                 3265                

tgc tgt ggc aga  atg ccg tac tcc acc  tca gga aac cag att  tgc       10230
Cys Cys Gly Arg  Met Pro Tyr Ser Thr  Ser Gly Asn Gln Ile  Cys            
            3270                 3275                 3280                

tgt gct ggg agg  ctt cat gat ggc cat  ggc cag aag tgc tgt  ggc       10275
Cys Ala Gly Arg  Leu His Asp Gly His  Gly Gln Lys Cys Cys  Gly            
            3285                 3290                 3295                

aga cag att gtg  agc aac gat tta gag  tgt tgt ggt gga gaa  gaa       10320
Arg Gln Ile Val  Ser Asn Asp Leu Glu  Cys Cys Gly Gly Glu  Glu            
            3300                 3305                 3310                

gga gtg gtg tac  aat cgc ctt cca ggt  atg ttc tgt tgt ggg  cag       10365
Gly Val Val Tyr  Asn Arg Leu Pro Gly  Met Phe Cys Cys Gly  Gln            
            3315                 3320                 3325                

gat tat gtg aat  atg tca gat acc ata  tgc tgc tca gct tcc  agt       10410
Asp Tyr Val Asn  Met Ser Asp Thr Ile  Cys Cys Ser Ala Ser  Ser            
            3330                 3335                 3340                

gga gag tct aaa  gca cat att aaa aag  aat gac ccg gtg cca  gta       10455
Gly Glu Ser Lys  Ala His Ile Lys Lys  Asn Asp Pro Val Pro  Val            
            3345                 3350                 3355                

aaa tgc tgt gag  act gaa ctt att cca  aag agc cag aaa tgc  tgt       10500
Lys Cys Cys Glu  Thr Glu Leu Ile Pro  Lys Ser Gln Lys Cys  Cys            
            3360                 3365                 3370                

aat gga gtt gga  tat aat cct ttg aaa  tat gtt tgc tct gac  aag       10545
Asn Gly Val Gly  Tyr Asn Pro Leu Lys  Tyr Val Cys Ser Asp  Lys            
            3375                 3380                 3385                

att tca act gga  atg atg atg aag gaa  acc aaa gag tgc agg  atc       10590
Ile Ser Thr Gly  Met Met Met Lys Glu  Thr Lys Glu Cys Arg  Ile            
            3390                 3395                 3400                

ctc tgc cca gca  tct atg gaa gcc aca  gaa cat tgt ggc agg  tgt       10635
Leu Cys Pro Ala  Ser Met Glu Ala Thr  Glu His Cys Gly Arg  Cys            
            3405                 3410                 3415                

gac ttc aac ttt  acc agc cac att tgc  act gtg ata aga ggg  tct       10680
Asp Phe Asn Phe  Thr Ser His Ile Cys  Thr Val Ile Arg Gly  Ser            
            3420                 3425                 3430                

cac aat tcc aca  ggg aag gca tca att  gaa gaa atg tgt tca  tct       10725
His Asn Ser Thr  Gly Lys Ala Ser Ile  Glu Glu Met Cys Ser  Ser            
            3435                 3440                 3445                

gcc gaa gaa acc  att cat aca ggg agt  gta aac acg tac tct  tac       10770
Ala Glu Glu Thr  Ile His Thr Gly Ser  Val Asn Thr Tyr Ser  Tyr            
            3450                 3455                 3460                

aca gat gtg aac  ctc aag ccc tac atg  aca tat gag tac agg  att       10815
Thr Asp Val Asn  Leu Lys Pro Tyr Met  Thr Tyr Glu Tyr Arg  Ile            
            3465                 3470                 3475                

tct gcc tgg aac  agc tat ggg cga gga  ctc agc aaa gct gtg  aga       10860
Ser Ala Trp Asn  Ser Tyr Gly Arg Gly  Leu Ser Lys Ala Val  Arg            
            3480                 3485                 3490                

gcc aga aca aaa  gaa gat gtg cct caa  gga gtg agt ccc cct  acg       10905
Ala Arg Thr Lys  Glu Asp Val Pro Gln  Gly Val Ser Pro Pro  Thr            
            3495                 3500                 3505                

tgg acc aaa ata  gac aat ctt gaa gat  aca att gtc tta aac  tgg       10950
Trp Thr Lys Ile  Asp Asn Leu Glu Asp  Thr Ile Val Leu Asn  Trp            
            3510                 3515                 3520                

aga aaa cct ata  caa tca aat ggt cct  att att tac tac atc  ctt       10995
Arg Lys Pro Ile  Gln Ser Asn Gly Pro  Ile Ile Tyr Tyr Ile  Leu            
            3525                 3530                 3535                

ctt cga aat gga  att gaa cgt ttt cgg  gga aca tca ctg agc  ttc       11040
Leu Arg Asn Gly  Ile Glu Arg Phe Arg  Gly Thr Ser Leu Ser  Phe            
            3540                 3545                 3550                

tct gat aaa gag  gga att caa cca ttt  cag gaa tat tca tat  cag       11085
Ser Asp Lys Glu  Gly Ile Gln Pro Phe  Gln Glu Tyr Ser Tyr  Gln            
            3555                 3560                 3565                

ctg aaa gct tgc  acg gtt gct ggc tgt  gcc acc agt agc aag  gta       11130
Leu Lys Ala Cys  Thr Val Ala Gly Cys  Ala Thr Ser Ser Lys  Val            
            3570                 3575                 3580                

gtt gca gct act  acc caa gga gtt ccg  gag agc atc ctg cca  cca       11175
Val Ala Ala Thr  Thr Gln Gly Val Pro  Glu Ser Ile Leu Pro  Pro            
            3585                 3590                 3595                

agc atc aca gcc  cta agt gca gtg gct  ctg cat ctg agc tgg  agt       11220
Ser Ile Thr Ala  Leu Ser Ala Val Ala  Leu His Leu Ser Trp  Ser            
            3600                 3605                 3610                

gtc cct gag aaa  tca aac ggc gtc att  aaa gag tac cag atc  agg       11265
Val Pro Glu Lys  Ser Asn Gly Val Ile  Lys Glu Tyr Gln Ile  Arg            
            3615                 3620                 3625                

cag gtt ggg aaa  ggt ctc atc cac act  gac acc act gac agg  aga       11310
Gln Val Gly Lys  Gly Leu Ile His Thr  Asp Thr Thr Asp Arg  Arg            
            3630                 3635                 3640                

cag cat acg gtc  aca ggt ctc cag cca  tac acc aac tac agc  ttc       11355
Gln His Thr Val  Thr Gly Leu Gln Pro  Tyr Thr Asn Tyr Ser  Phe            
            3645                 3650                 3655                

act ctt aca gct  tgt aca tct gct ggg  tgc act tca agc gag  cct       11400
Thr Leu Thr Ala  Cys Thr Ser Ala Gly  Cys Thr Ser Ser Glu  Pro            
            3660                 3665                 3670                

ttt cta ggt cag  aca ctg cag gca gct  cct gaa gga gtt tgg  gtg       11445
Phe Leu Gly Gln  Thr Leu Gln Ala Ala  Pro Glu Gly Val Trp  Val            
            3675                 3680                 3685                

aca cct cga cac  att atc atc aat tct  aca aca gtg gaa tta  tat       11490
Thr Pro Arg His  Ile Ile Ile Asn Ser  Thr Thr Val Glu Leu  Tyr            
            3690                 3695                 3700                

tgg agt ctg cca  gaa aag ccc aat ggc  ctc gtt tct caa tat  caa       11535
Trp Ser Leu Pro  Glu Lys Pro Asn Gly  Leu Val Ser Gln Tyr  Gln            
            3705                 3710                 3715                

ttg agt cgt aat  gga aac ttg ctt ttc  ctg ggt ggc agt gag  gag       11580
Leu Ser Arg Asn  Gly Asn Leu Leu Phe  Leu Gly Gly Ser Glu  Glu            
            3720                 3725                 3730                

cag aat ttc act  gat aaa aac ctg gag  ccc aat agc aga tac  act       11625
Gln Asn Phe Thr  Asp Lys Asn Leu Glu  Pro Asn Ser Arg Tyr  Thr            
            3735                 3740                 3745                

tac aag tta gaa  gtc aaa act gga ggt  ggc agc agt gct agt  gat       11670
Tyr Lys Leu Glu  Val Lys Thr Gly Gly  Gly Ser Ser Ala Ser  Asp            
            3750                 3755                 3760                

gat tac att gtt  caa aca cct atg tca  aca cca gaa gaa atc  tat       11715
Asp Tyr Ile Val  Gln Thr Pro Met Ser  Thr Pro Glu Glu Ile  Tyr            
            3765                 3770                 3775                

cct cca tat aat  atc aca gta att ggg  cct tat tct ata ttt  gta       11760
Pro Pro Tyr Asn  Ile Thr Val Ile Gly  Pro Tyr Ser Ile Phe  Val            
            3780                 3785                 3790                

gct tgg ata cca  cca ggg atc ctc atc  ccc gaa att cct gtg  gag       11805
Ala Trp Ile Pro  Pro Gly Ile Leu Ile  Pro Glu Ile Pro Val  Glu            
            3795                 3800                 3805                

tac aat gtc tta  ctc aat gat gga agt  gta aca cct ctg gcc  ttc       11850
Tyr Asn Val Leu  Leu Asn Asp Gly Ser  Val Thr Pro Leu Ala  Phe            
            3810                 3815                 3820                

tcc gtt ggt cat  cat caa tcc acc ctt  ctg gaa aat ttg act  cca       11895
Ser Val Gly His  His Gln Ser Thr Leu  Leu Glu Asn Leu Thr  Pro            
            3825                 3830                 3835                

ttc aca cag tat  gag ata agg ata caa  gca tgt caa aat gga  agt       11940
Phe Thr Gln Tyr  Glu Ile Arg Ile Gln  Ala Cys Gln Asn Gly  Ser            
            3840                 3845                 3850                

tgt gga gtt agc  agt agg atg ttt gtc  aaa aca cct gaa gca  gcc       11985
Cys Gly Val Ser  Ser Arg Met Phe Val  Lys Thr Pro Glu Ala  Ala            
            3855                 3860                 3865                

cca atg gat ctt  aat tct cct gtt ctt  aag gca ctg ggg tca  gct       12030
Pro Met Asp Leu  Asn Ser Pro Val Leu  Lys Ala Leu Gly Ser  Ala            
            3870                 3875                 3880                

tgc ata gag att  aag tgg atg cca cct  gaa aaa cca aat gga  atc       12075
Cys Ile Glu Ile  Lys Trp Met Pro Pro  Glu Lys Pro Asn Gly  Ile            
            3885                 3890                 3895                

atc atc aac tac  ttt att tac aga cgc  cct gct ggc att gaa  gag       12120
Ile Ile Asn Tyr  Phe Ile Tyr Arg Arg  Pro Ala Gly Ile Glu  Glu            
            3900                 3905                 3910                

gag tct gtt tta  ttt gtc tgg tca gaa  gga gcc ctt gaa ttt  atg       12165
Glu Ser Val Leu  Phe Val Trp Ser Glu  Gly Ala Leu Glu Phe  Met            
            3915                 3920                 3925                

gat gaa gga gac  acc ctg agg cct ttc  aca ctc tac gaa tat  cgg       12210
Asp Glu Gly Asp  Thr Leu Arg Pro Phe  Thr Leu Tyr Glu Tyr  Arg            
            3930                 3935                 3940                

gtc aga gcc tgt  aac tcc aag ggt tca  gtg gag agt ctg tgg  tca       12255
Val Arg Ala Cys  Asn Ser Lys Gly Ser  Val Glu Ser Leu Trp  Ser            
            3945                 3950                 3955                

tta aca caa act  ctg gaa gct cca cct  caa gat ttt cca gct  cct       12300
Leu Thr Gln Thr  Leu Glu Ala Pro Pro  Gln Asp Phe Pro Ala  Pro            
            3960                 3965                 3970                

tgg gct caa gcc  acg agt gct cat tca  gtt ctg ttg aat tgg  aca       12345
Trp Ala Gln Ala  Thr Ser Ala His Ser  Val Leu Leu Asn Trp  Thr            
            3975                 3980                 3985                

aag cca gaa tct  ccc aat ggc att atc  tcc cat tac cgt gtg  gtc       12390
Lys Pro Glu Ser  Pro Asn Gly Ile Ile  Ser His Tyr Arg Val  Val            
            3990                 3995                 4000                

tac cag gag aga  ccc gac gat cct aca  ttt aac agc cct acc  gtg       12435
Tyr Gln Glu Arg  Pro Asp Asp Pro Thr  Phe Asn Ser Pro Thr  Val            
            4005                 4010                 4015                

cat gct ttc aca  gtg aag gga aca agc  cat caa gcc cac ctg  tac       12480
His Ala Phe Thr  Val Lys Gly Thr Ser  His Gln Ala His Leu  Tyr            
            4020                 4025                 4030                

ggg tta gaa cca  ttc aca aca tat cgc  att ggt gtt gtg gct  gca       12525
Gly Leu Glu Pro  Phe Thr Thr Tyr Arg  Ile Gly Val Val Ala  Ala            
            4035                 4040                 4045                

aac cat gca gga  gaa att tta agc cct  tgg act ctg att caa  acc       12570
Asn His Ala Gly  Glu Ile Leu Ser Pro  Trp Thr Leu Ile Gln  Thr            
            4050                 4055                 4060                

tta gaa tct tcc  cca agt gga ctg aga  aac ttt ata gta gaa  cag       12615
Leu Glu Ser Ser  Pro Ser Gly Leu Arg  Asn Phe Ile Val Glu  Gln            
            4065                 4070                 4075                

aaa gag aat ggc  cgg gca ttg cta cta  cag tgg tca gaa cct  atg       12660
Lys Glu Asn Gly  Arg Ala Leu Leu Leu  Gln Trp Ser Glu Pro  Met            
            4080                 4085                 4090                

aga acc aat ggt  gtg att aag aca tac  aac atc ttc agt gac  ggg       12705
Arg Thr Asn Gly  Val Ile Lys Thr Tyr  Asn Ile Phe Ser Asp  Gly            
            4095                 4100                 4105                

ttc ctg gag tac  tct ggt ttg aat cgt  cag ttt ctc ttc cgc  cgc       12750
Phe Leu Glu Tyr  Ser Gly Leu Asn Arg  Gln Phe Leu Phe Arg  Arg            
            4110                 4115                 4120                

ctg gat cct ttc  act ctc tac aca ctg  acc ctg gag gcc tgc  acc       12795
Leu Asp Pro Phe  Thr Leu Tyr Thr Leu  Thr Leu Glu Ala Cys  Thr            
            4125                 4130                 4135                

aga gca ggt tgt  gca cac tcg gcg cct  cag cct ctg tgg aca  gat       12840
Arg Ala Gly Cys  Ala His Ser Ala Pro  Gln Pro Leu Trp Thr  Asp            
            4140                 4145                 4150                

gaa gcc cct cca  gac tct cag ctg gct  cct act gtc cac tct  gtg       12885
Glu Ala Pro Pro  Asp Ser Gln Leu Ala  Pro Thr Val His Ser  Val            
            4155                 4160                 4165                

aag tcc acc agt  gtt gag ctg agc tgg  tct gag cct gtt aac  cca       12930
Lys Ser Thr Ser  Val Glu Leu Ser Trp  Ser Glu Pro Val Asn  Pro            
            4170                 4175                 4180                

aat gga aaa ata  att cgc tat gaa gtg  att cgc aga tgc ttc  gag       12975
Asn Gly Lys Ile  Ile Arg Tyr Glu Val  Ile Arg Arg Cys Phe  Glu            
            4185                 4190                 4195                

gga aaa gct tgg  gga aat cag acg atc  cag gcc gac gag aaa  att       13020
Gly Lys Ala Trp  Gly Asn Gln Thr Ile  Gln Ala Asp Glu Lys  Ile            
            4200                 4205                 4210                

gtt ttc aca gaa  tat aac act gaa agg  aat aca ttt atg tat  aat       13065
Val Phe Thr Glu  Tyr Asn Thr Glu Arg  Asn Thr Phe Met Tyr  Asn            
            4215                 4220                 4225                

gac aca ggt ttg  caa cca tgg acg cag  tgt gaa tat aaa atc  tac       13110
Asp Thr Gly Leu  Gln Pro Trp Thr Gln  Cys Glu Tyr Lys Ile  Tyr            
            4230                 4235                 4240                

act tgg aat tca  gct ggg cat acc tgt  agc tct tgg aat gtg  gtg       13155
Thr Trp Asn Ser  Ala Gly His Thr Cys  Ser Ser Trp Asn Val  Val            
            4245                 4250                 4255                

agg aca ttg caa  gca cct cca gaa ggt  ctc tct cca cct gtg  ata       13200
Arg Thr Leu Gln  Ala Pro Pro Glu Gly  Leu Ser Pro Pro Val  Ile            
            4260                 4265                 4270                

tcc tat gtt tct  atg aat ccc caa aaa  ctg ctg att tcc tgg  atc       13245
Ser Tyr Val Ser  Met Asn Pro Gln Lys  Leu Leu Ile Ser Trp  Ile            
            4275                 4280                 4285                

cca cca gaa cag  tct aat ggt att atc  cag tcc tat agg ctt  caa       13290
Pro Pro Glu Gln  Ser Asn Gly Ile Ile  Gln Ser Tyr Arg Leu  Gln            
            4290                 4295                 4300                

agg aat gaa atg  ctc tat cct ttt agc  ttt gat cct gtg act  ttc       13335
Arg Asn Glu Met  Leu Tyr Pro Phe Ser  Phe Asp Pro Val Thr  Phe            
            4305                 4310                 4315                

aat tac act gat  gaa gag ctt ctt cct  ttt tcc acc tat agc  tat       13380
Asn Tyr Thr Asp  Glu Glu Leu Leu Pro  Phe Ser Thr Tyr Ser  Tyr            
            4320                 4325                 4330                

gca ctc caa gcc  tgc acg agt gga gga  tgc tcc acc agc aaa  ccc       13425
Ala Leu Gln Ala  Cys Thr Ser Gly Gly  Cys Ser Thr Ser Lys  Pro            
            4335                 4340                 4345                

acc agc atc aca  act ctg gag gct gct  cca tca gaa gtc agc  cct       13470
Thr Ser Ile Thr  Thr Leu Glu Ala Ala  Pro Ser Glu Val Ser  Pro            
            4350                 4355                 4360                

cca gat ctt tgg  gcc gtc agt gcc act  caa atg aat gta tgt  tgg       13515
Pro Asp Leu Trp  Ala Val Ser Ala Thr  Gln Met Asn Val Cys  Trp            
            4365                 4370                 4375                

tca ccg ccc aca  gtg caa aat gga aag  att act aaa tat tta  gtt       13560
Ser Pro Pro Thr  Val Gln Asn Gly Lys  Ile Thr Lys Tyr Leu  Val            
            4380                 4385                 4390                

aga tat gat aat  aaa gag tcc ctt gct  ggc cag ggc ctg tgc  ctg       13605
Arg Tyr Asp Asn  Lys Glu Ser Leu Ala  Gly Gln Gly Leu Cys  Leu            
            4395                 4400                 4405                

ctg gtt tcc cac  ctg cag cct tac tct  cag tat aac ttc tcc  ctt       13650
Leu Val Ser His  Leu Gln Pro Tyr Ser  Gln Tyr Asn Phe Ser  Leu            
            4410                 4415                 4420                

gta gcc tgc acg  aat gga ggt tgc aca  gct agt gtg tca aaa  tct       13695
Val Ala Cys Thr  Asn Gly Gly Cys Thr  Ala Ser Val Ser Lys  Ser            
            4425                 4430                 4435                

gcc tgg aca atg  gag gcc ctg cca gag  aac atg gac tct cca  aca       13740
Ala Trp Thr Met  Glu Ala Leu Pro Glu  Asn Met Asp Ser Pro  Thr            
            4440                 4445                 4450                

ttg caa gtc aca  ggc tca gaa tca ata  gaa atc acc tgg aaa  cct       13785
Leu Gln Val Thr  Gly Ser Glu Ser Ile  Glu Ile Thr Trp Lys  Pro            
            4455                 4460                 4465                

cca aga aac cca  aat ggc cag atc aga  agt tat gaa ctt agg  agg       13830
Pro Arg Asn Pro  Asn Gly Gln Ile Arg  Ser Tyr Glu Leu Arg  Arg            
            4470                 4475                 4480                

gat gga acc att  gta tat aca ggc ttg  gaa aca cgc tat cgt  gat       13875
Asp Gly Thr Ile  Val Tyr Thr Gly Leu  Glu Thr Arg Tyr Arg  Asp            
            4485                 4490                 4495                

ttt act ctc acc  cca ggt gtg gag tat  agc tac aca gta act  gcc       13920
Phe Thr Leu Thr  Pro Gly Val Glu Tyr  Ser Tyr Thr Val Thr  Ala            
            4500                 4505                 4510                

agc aac agc caa  ggg ggt att ttg agt  cct ctt gtc aaa gat  cga       13965
Ser Asn Ser Gln  Gly Gly Ile Leu Ser  Pro Leu Val Lys Asp  Arg            
            4515                 4520                 4525                

acc agc ccc tca  gca ccc tca ggg atg  gaa cct cca aaa ttg  cag       14010
Thr Ser Pro Ser  Ala Pro Ser Gly Met  Glu Pro Pro Lys Leu  Gln            
            4530                 4535                 4540                

gcc agg ggt cct  cag gag atc tta gtg  aac tgg gac cct cca  gtg       14055
Ala Arg Gly Pro  Gln Glu Ile Leu Val  Asn Trp Asp Pro Pro  Val            
            4545                 4550                 4555                

aga aca aat ggt  gat atc atc aat tat  acc ctc ttc atc cgt  gaa       14100
Arg Thr Asn Gly  Asp Ile Ile Asn Tyr  Thr Leu Phe Ile Arg  Glu            
            4560                 4565                 4570                

cta ttt gaa aga  gaa act aaa atc ata  cac ata aac aca act  cat       14145
Leu Phe Glu Arg  Glu Thr Lys Ile Ile  His Ile Asn Thr Thr  His            
            4575                 4580                 4585                

aat tct ttt ggt  atg cag tca tat ata  gta aac cag ctg aag  cca       14190
Asn Ser Phe Gly  Met Gln Ser Tyr Ile  Val Asn Gln Leu Lys  Pro            
            4590                 4595                 4600                

ttt cac agg tat  gaa ata cga att caa  gcg tgc acc acc ctg  gga       14235
Phe His Arg Tyr  Glu Ile Arg Ile Gln  Ala Cys Thr Thr Leu  Gly            
            4605                 4610                 4615                

tgt gca tca agt  gac tgg aca ttc ata  cag acc cct gag att  gca       14280
Cys Ala Ser Ser  Asp Trp Thr Phe Ile  Gln Thr Pro Glu Ile  Ala            
            4620                 4625                 4630                

cct ttg atg caa  ccc cct cca cat ctg  gag gta caa atg gct  cca       14325
Pro Leu Met Gln  Pro Pro Pro His Leu  Glu Val Gln Met Ala  Pro            
            4635                 4640                 4645                

gga gga ttc cag  cca act gtt tct ctt  ttg tgg aca gga ccg  ctg       14370
Gly Gly Phe Gln  Pro Thr Val Ser Leu  Leu Trp Thr Gly Pro  Leu            
            4650                 4655                 4660                

cag cca aat gga  aaa gtt ttg tat tac  gaa tta tac aga aga  caa       14415
Gln Pro Asn Gly  Lys Val Leu Tyr Tyr  Glu Leu Tyr Arg Arg  Gln            
            4665                 4670                 4675                

ata gca act cag  cct aga aaa tcc aat  cca gtc cta atc tat  aac       14460
Ile Ala Thr Gln  Pro Arg Lys Ser Asn  Pro Val Leu Ile Tyr  Asn            
            4680                 4685                 4690                

gga agc tca aca  tct ttt ata gat tcc  gaa cta ttg cct ttc  aca       14505
Gly Ser Ser Thr  Ser Phe Ile Asp Ser  Glu Leu Leu Pro Phe  Thr            
            4695                 4700                 4705                

gag tat gag tat  cag gtc tgg gca gtg  aat tct gca gga aaa  gcc       14550
Glu Tyr Glu Tyr  Gln Val Trp Ala Val  Asn Ser Ala Gly Lys  Ala            
            4710                 4715                 4720                

ccc agt agc tgg  aca tgg tgc aga acc  ggg cca gcc cca cca  gaa       14595
Pro Ser Ser Trp  Thr Trp Cys Arg Thr  Gly Pro Ala Pro Pro  Glu            
            4725                 4730                 4735                

ggt ctc aga gcc  ccc acg ttc cat gtg  atc tct tct acc caa  gca       14640
Gly Leu Arg Ala  Pro Thr Phe His Val  Ile Ser Ser Thr Gln  Ala            
            4740                 4745                 4750                

gtg gtc aac atc  agt gcc cct ggg aag  ccc aac ggg atc gtc  agt       14685
Val Val Asn Ile  Ser Ala Pro Gly Lys  Pro Asn Gly Ile Val  Ser            
            4755                 4760                 4765                

ctc tac agg ctg  ttc tcc agc agc gcc  cat ggg gct gag aca  gtg       14730
Leu Tyr Arg Leu  Phe Ser Ser Ser Ala  His Gly Ala Glu Thr  Val            
            4770                 4775                 4780                

cta tcc gaa ggc  atg gcc acc cag cag  act ctc cat ggc ctt  caa       14775
Leu Ser Glu Gly  Met Ala Thr Gln Gln  Thr Leu His Gly Leu  Gln            
            4785                 4790                 4795                

gcc ttc act aac  tac tct att gga gta  gag gcc tgc acc tgc  ttc       14820
Ala Phe Thr Asn  Tyr Ser Ile Gly Val  Glu Ala Cys Thr Cys  Phe            
            4800                 4805                 4810                

aac tgt tgc agc  aaa gga ccg aca gct  gaa ctg aga acc cat  cct       14865
Asn Cys Cys Ser  Lys Gly Pro Thr Ala  Glu Leu Arg Thr His  Pro            
            4815                 4820                 4825                

gcc cca ccc tca  gga ctg tcc tct cca  caa atc ggg acg ctg  gcc       14910
Ala Pro Pro Ser  Gly Leu Ser Ser Pro  Gln Ile Gly Thr Leu  Ala            
            4830                 4835                 4840                

tca agg acg gcc  tcc ttc cgg tgg agt  ccc ccc atg ttc ccc  aat       14955
Ser Arg Thr Ala  Ser Phe Arg Trp Ser  Pro Pro Met Phe Pro  Asn            
            4845                 4850                 4855                

ggt gtc att cac  agc tat gaa ctc caa  ttc cac gtg gct tgc  cct       15000
Gly Val Ile His  Ser Tyr Glu Leu Gln  Phe His Val Ala Cys  Pro            
            4860                 4865                 4870                

cct gac tca gcc  ctc ccc tgt act ccc  agc caa ata gaa aca  aag       15045
Pro Asp Ser Ala  Leu Pro Cys Thr Pro  Ser Gln Ile Glu Thr  Lys            
            4875                 4880                 4885                

tac acg ggg ctg  ggg cag aaa gcc agc  ctt ggg ggt ctc cag  ccc       15090
Tyr Thr Gly Leu  Gly Gln Lys Ala Ser  Leu Gly Gly Leu Gln  Pro            
            4890                 4895                 4900                

tac acc aca tac  aag ctg aga gtg gtg  gca cac aac gag gtg  ggc       15135
Tyr Thr Thr Tyr  Lys Leu Arg Val Val  Ala His Asn Glu Val  Gly            
            4905                 4910                 4915                

agt acg gct tcc  gag tgg atc agt ttc  acc acc caa aaa gaa  ttg       15180
Ser Thr Ala Ser  Glu Trp Ile Ser Phe  Thr Thr Gln Lys Glu  Leu            
            4920                 4925                 4930                

cct cag tac cga  gcc cca ttt tcg gtg  gac agc aat ttg tct  gtg       15225
Pro Gln Tyr Arg  Ala Pro Phe Ser Val  Asp Ser Asn Leu Ser  Val            
            4935                 4940                 4945                

gtg tgt gtg aac  tgg agt gac acc ttc  ctc ctg aac ggc caa  ctg       15270
Val Cys Val Asn  Trp Ser Asp Thr Phe  Leu Leu Asn Gly Gln  Leu            
            4950                 4955                 4960                

aag gag tac gtg  tta acc gac gga ggg  cga cgc gtg tac agc  ggc       15315
Lys Glu Tyr Val  Leu Thr Asp Gly Gly  Arg Arg Val Tyr Ser  Gly            
            4965                 4970                 4975                

ttg gac acc acc  ctc tac ata ccg aga  acg gcg gac aaa acc  ttc       15360
Leu Asp Thr Thr  Leu Tyr Ile Pro Arg  Thr Ala Asp Lys Thr  Phe            
            4980                 4985                 4990                

ttt ttc cag gtc  atc tgc acg act gac  gaa gga agt gtt aag  acg       15405
Phe Phe Gln Val  Ile Cys Thr Thr Asp  Glu Gly Ser Val Lys  Thr            
            4995                 5000                 5005                

ccg ttg atc caa  tat gat acc tct act  gga ctt ggc ttg gtc  cta       15450
Pro Leu Ile Gln  Tyr Asp Thr Ser Thr  Gly Leu Gly Leu Val  Leu            
            5010                 5015                 5020                

aca act cct ggg  aaa aag aag gga tcg  cgg agc aaa agc aca  gag       15495
Thr Thr Pro Gly  Lys Lys Lys Gly Ser  Arg Ser Lys Ser Thr  Glu            
            5025                 5030                 5035                

ttc tac agc gag  ctg tgg ttc ata gtg  tta atg gcg atg ctg  ggc       15540
Phe Tyr Ser Glu  Leu Trp Phe Ile Val  Leu Met Ala Met Leu  Gly            
            5040                 5045                 5050                

ttg atc ttg ttg  gcc att ttt ctg tcc  ctg ata cta caa aga  aaa       15585
Leu Ile Leu Leu  Ala Ile Phe Leu Ser  Leu Ile Leu Gln Arg  Lys            
            5055                 5060                 5065                

atc cac aaa gag  cca tat atc aga gaa  aga cct ccc ttg gta  cct       15630
Ile His Lys Glu  Pro Tyr Ile Arg Glu  Arg Pro Pro Leu Val  Pro            
            5070                 5075                 5080                

ctt cag aag agg  atg tct cca ttg aat  gtt tac cca ccg ggg  gaa       15675
Leu Gln Lys Arg  Met Ser Pro Leu Asn  Val Tyr Pro Pro Gly  Glu            
            5085                 5090                 5095                

aac cat atg ggg  tta gcc gat acc aaa  att ccc cgg tct ggg  aca       15720
Asn His Met Gly  Leu Ala Asp Thr Lys  Ile Pro Arg Ser Gly  Thr            
            5100                 5105                 5110                

cct gtg agt atc  cgc agc aac cgg agt  gca tgt gtc ctg cgc  atc       15765
Pro Val Ser Ile  Arg Ser Asn Arg Ser  Ala Cys Val Leu Arg  Ile            
            5115                 5120                 5125                

ccg agt caa aac  caa acc agc cta acc  tac tcc cag ggt tct  ctt       15810
Pro Ser Gln Asn  Gln Thr Ser Leu Thr  Tyr Ser Gln Gly Ser  Leu            
            5130                 5135                 5140                

cac cgc agc gtc  agc cag ctc atg gac  att caa gac aag aaa  gtc       15855
His Arg Ser Val  Ser Gln Leu Met Asp  Ile Gln Asp Lys Lys  Val            
            5145                 5150                 5155                

ttg atg gac aac  tca ctg tgg gaa gcc  atc atg ggc cac aac  agt       15900
Leu Met Asp Asn  Ser Leu Trp Glu Ala  Ile Met Gly His Asn  Ser            
            5160                 5165                 5170                

gga ctg tat gtg  gat gaa gag gac ctg  atg aac gcc atc aag  gat       15945
Gly Leu Tyr Val  Asp Glu Glu Asp Leu  Met Asn Ala Ile Lys  Asp            
            5175                 5180                 5185                

ttc agc tca gtg  act aag gaa cgc acc  aca ttc aca gac acc  cac       15990
Phe Ser Ser Val  Thr Lys Glu Arg Thr  Thr Phe Thr Asp Thr  His            
            5190                 5195                 5200                

ctg taa aggatggaaa cccagaagac gtaaccctgg aatgcaaggt ctgcacccat       16046
Leu                                                                       
                                                                          

ttcctcctgg gttatcactc acacatcata aatgctgaaa agccattgtt tattatccta    16106

taattcttta aagaaatgat gactgttttt gaaagtgttc cttcctaata gaggtctaag    16166

aaatgatatt tttctcatct taaatgagag agaatattca tatgaaaata cttgatttgc    16226

tcttattttg tagaagacaa agaagtatgt aattgtcact tggttctgtt tggcagtgat    16286

gctcctggtt aactgaataa tcagtggcaa tttcaagatg gctcacagtt gttagaagta    16346

gtaagttagt tactggctca aaaatgattc tgttgaaagg atgtcactgc tgttcatttc    16406

tatctgccat ttctgtcagg gttgacacaa tcctgcaaga atagttattc taatgatcac    16466

agctgctaaa tgaatcccaa actttgcacc aggtcgacaa acttttctga aggttctatt    16526

tatttaccat acatagggtt acttaccaaa ctttttgaca aggctgaagg ttctatttat    16586

ttacaataca tagggttact caccaaactt tttgacaagg caacacataa cttacacata    16646

aatgtctctg ttcttgcatt tatgaatttt ccaaaaatct aaggagtaaa cagcttattt    16706

atacattttg aggagaaaac aaagtgtttc actaggaaca cctctacttg aaccaatgtt    16766

tttatttcat atattttata gttttgaaac tagtttctca taaaattctg tcaattcact    16826

gaatatcaga gaatactgac atcttcaacc tagcacattt caaatggaaa ctactgttct    16886

atttgcaata ttaggctgcg tgaaatttta aaaggaaaaa tgtatctgtt ccttctagca    16946

ttaacatata tacatgtaga gacaagacta tacctatgtg tatatatatg tatatcatgt    17006

atatattact ctgcactata tcccttcttt ttggagaact agccattatt ttagccacag    17066

aatcagtaag aacagatgat atgcaacagt accaattacg gttcaaaaat gtctgtcacc    17126

tgctctagtt ggattacaaa gtcattggtg aaagtcctat ggcaagaaaa attttcttgc    17186

aaatcatcca cataaaatca gatatttaaa tttgttcttc atggaaaaca gagtaagaaa    17246

acctcttgtc ttccttcatc cttaaaggtc tttgtgaccc caggaaaata ttgactctgt    17306

ctaacacaca atagtcacaa tactttttgt gaatctacaa ccagagacag gcaaaaactt    17366

gtaaagtaag ggatagtctt acttattctg cctgaaaaca atgtattacc ccagggccca    17426

acagtaaaag attgtggact ttttgggtat tgagatttca tctagctctg tgagagagca    17486

gctcctcaga ctgaccaact cctagacaaa gtttgccaac cataagtgtc aaaagcacag    17546

gccagtatta agcagaagtt ctaccacctt attagaactg ctataaacaa aagcatctga    17606

aataattgtg cacatctggc agtgactgta gaaaatacga aatatatatt tctcgccaag    17666

tttttatact ttctgaaatg aaaacatagg attgactagt ttactggttt ttattcccat    17726

atgccgattc tgggacaata aagttgttta aagctggcac aaataagcat taaccaaggc    17786

tgtgtccacc ttctgtgagc tacttaaggt atataggaaa ggagtggtca caaacttgca    17846

tcctaatcct tggtggactc ttctaagaat acagtttgct agtcacaaag aatagtctac    17906

aaatatgctt tgctaggttc agaagattga gtttatcctg atttttgaaa aattaaccag    17966

gtatctttat cactgtgtat ttttccaagc acagtataaa attttaacaa cgcacaaaaa    18026

aatacagaac tgcaggggat tttatcttgg atcattatcc atttaatcat ctaattagac    18086

atgaactcag ttagctgaat catttacatt ttgactccat agcttagggc agacagaagc    18146

ctgtatggct tctgcccaga actctgtccc ctgctacatg tctaagttta cttgtattta    18206

tttcagagaa gaactctaag atgttgcttt gctactttaa gtggtattgc gtgccaagcc    18266

tctattatac aaaccatgca gactcgcctc tagagattct gattcggttg atctggggtg    18326

tgtggctgag gcatcagtac tttttaaagc ttccaggtgt tctaatgttg agacccactg    18386

atgttccaca atctggaaga aatcatgtac aggaataata tgctatgcac agggactatg    18446

ctccttggct caccccttct cccttataaa caatgagcag ttcttgatga acctctttaa    18506

atttaaatct cctgactcac attttaccaa ttgtacatgc cacattctca gcttacgaac    18566

taccatgttt tgttattctt aatatcaact gtttggtaag agtacagttg tttttataca    18626

ctctaagaaa tgtgtttata atctactgta atttccacta aatggaaccc aaatattaat    18686

gttatggtac catatactga tgtaaaaatc atgctggcat ccatgaacac accggtaaat    18746

aaaacatagt ccaagtggaa gaattcatta ataaggaact tttaattatg tcacaaatga    18806

atagttggtt tccaatgcac aaatatcatg taaactaatc taaagatggt ttgcttaata    18866

aatatttgaa tgtgacc                                                   18883


<210>  156
<211>  5202
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Lys 
        35                  40                  45              


Val Ser Ile Val Pro Thr Gln Ala Val Cys Gly Leu Pro Asp Arg Ser 
    50                  55                  60                  


Thr Phe Cys His Ser Ser Ala Ala Ala Glu Ser Ile Gln Phe Cys Thr 
65                  70                  75                  80  


Gln Arg Phe Cys Ile Gln Asp Cys Pro Tyr Arg Ser Ser His Pro Thr 
                85                  90                  95      


Tyr Thr Ala Leu Phe Ser Ala Gly Leu Ser Ser Cys Ile Thr Pro Asp 
            100                 105                 110         


Lys Asn Asp Leu His Pro Asn Ala His Ser Asn Ser Ala Ser Phe Ile 
        115                 120                 125             


Phe Gly Asn His Lys Ser Cys Phe Ser Ser Pro Pro Ser Pro Lys Leu 
    130                 135                 140                 


Met Ala Ser Phe Thr Leu Ala Val Trp Leu Lys Pro Glu Gln Gln Gly 
145                 150                 155                 160 


Val Met Cys Val Ile Glu Lys Thr Val Asp Gly Gln Ile Val Phe Lys 
                165                 170                 175     


Leu Thr Ile Ser Glu Lys Glu Thr Met Phe Tyr Tyr Arg Thr Val Asn 
            180                 185                 190         


Gly Leu Gln Pro Pro Ile Lys Val Met Thr Leu Gly Arg Ile Leu Val 
        195                 200                 205             


Lys Lys Trp Ile His Leu Ser Val Gln Val His Gln Thr Lys Ile Ser 
    210                 215                 220                 


Phe Phe Ile Asn Gly Val Glu Lys Asp His Thr Pro Phe Asn Ala Arg 
225                 230                 235                 240 


Thr Leu Ser Gly Ser Ile Thr Asp Phe Ala Ser Gly Thr Val Gln Ile 
                245                 250                 255     


Gly Gln Ser Leu Asn Gly Leu Glu Gln Phe Val Gly Arg Met Gln Asp 
            260                 265                 270         


Phe Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg Glu Ile Leu Glu Val 
        275                 280                 285             


Phe Ser Gly Asp Leu Leu Arg Leu His Ala Gln Ser His Cys Arg Cys 
    290                 295                 300                 


Pro Gly Ser His Pro Arg Val His Pro Leu Ala Gln Arg Tyr Cys Ile 
305                 310                 315                 320 


Pro Asn Asp Ala Gly Asp Thr Ala Asp Asn Arg Val Ser Arg Leu Asn 
                325                 330                 335     


Pro Glu Ala His Pro Leu Ser Phe Val Asn Asp Asn Asp Val Gly Thr 
            340                 345                 350         


Ser Trp Val Ser Asn Val Phe Thr Asn Ile Thr Gln Leu Asn Gln Gly 
        355                 360                 365             


Val Thr Ile Ser Val Asp Leu Glu Asn Gly Gln Tyr Gln Val Phe Tyr 
    370                 375                 380                 


Ile Ile Ile Gln Phe Phe Ser Pro Gln Pro Thr Glu Ile Arg Ile Gln 
385                 390                 395                 400 


Arg Lys Lys Glu Asn Ser Leu Asp Trp Glu Asp Trp Gln Tyr Phe Ala 
                405                 410                 415     


Arg Asn Cys Gly Ala Phe Gly Met Lys Asn Asn Gly Asp Leu Glu Lys 
            420                 425                 430         


Pro Asp Ser Val Asn Cys Leu Gln Leu Ser Asn Phe Thr Pro Tyr Ser 
        435                 440                 445             


Arg Gly Asn Val Thr Phe Ser Ile Leu Thr Pro Gly Pro Asn Tyr Arg 
    450                 455                 460                 


Pro Gly Tyr Asn Asn Phe Tyr Asn Thr Pro Ser Leu Gln Glu Phe Val 
465                 470                 475                 480 


Lys Ala Thr Gln Ile Arg Phe His Phe His Gly Gln Tyr Tyr Thr Thr 
                485                 490                 495     


Glu Thr Ala Val Asn Leu Arg His Arg Tyr Tyr Ala Val Asp Glu Ile 
            500                 505                 510         


Thr Ile Ser Gly Arg Cys Gln Cys His Gly His Ala Asp Asn Cys Asp 
        515                 520                 525             


Thr Thr Ser Gln Pro Tyr Arg Cys Leu Cys Ser Gln Glu Ser Phe Thr 
    530                 535                 540                 


Glu Gly Leu His Cys Asp Arg Cys Leu Pro Leu Tyr Asn Asp Lys Pro 
545                 550                 555                 560 


Phe Arg Gln Gly Asp Gln Val Tyr Ala Phe Asn Cys Lys Pro Cys Gln 
                565                 570                 575     


Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val Asp Pro 
            580                 585                 590         


Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp Asp Cys 
        595                 600                 605             


Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp Tyr Phe 
    610                 615                 620                 


Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys Lys Pro 
625                 630                 635                 640 


Cys Asp Cys Asp Thr Val Gly Thr Arg Asn Gly Ser Ile Leu Cys Asp 
                645                 650                 655     


Gln Ile Gly Gly Gln Cys Asn Cys Lys Arg His Val Ser Gly Arg Gln 
            660                 665                 670         


Cys Asn Gln Cys Gln Asn Gly Phe Tyr Asn Leu Gln Glu Leu Asp Pro 
        675                 680                 685             


Asp Gly Cys Ser Pro Cys Asn Cys Asn Thr Ser Gly Thr Val Asp Gly 
    690                 695                 700                 


Asp Ile Thr Cys His Gln Asn Ser Gly Gln Cys Lys Cys Lys Ala Asn 
705                 710                 715                 720 


Val Ile Gly Leu Arg Cys Asp His Cys Asn Phe Gly Phe Lys Phe Leu 
                725                 730                 735     


Arg Ser Phe Asn Asp Val Gly Cys Glu Pro Cys Gln Cys Asn Leu His 
            740                 745                 750         


Gly Ser Val Asn Lys Phe Cys Asn Pro His Ser Gly Gln Cys Glu Cys 
        755                 760                 765             


Lys Lys Glu Ala Lys Gly Leu Gln Cys Asp Thr Cys Arg Glu Asn Phe 
    770                 775                 780                 


Tyr Gly Leu Asp Val Thr Asn Cys Lys Ala Cys Asp Cys Asp Thr Ala 
785                 790                 795                 800 


Gly Ser Leu Pro Gly Thr Val Cys Asn Ala Lys Thr Gly Gln Cys Ile 
                805                 810                 815     


Cys Lys Pro Asn Val Glu Gly Arg Gln Cys Asn Lys Cys Leu Glu Gly 
            820                 825                 830         


Asn Phe Tyr Leu Arg Gln Asn Asn Ser Phe Leu Cys Leu Pro Cys Asn 
        835                 840                 845             


Cys Asp Lys Thr Gly Thr Ile Asn Gly Ser Leu Leu Cys Asn Lys Ser 
    850                 855                 860                 


Thr Gly Gln Cys Pro Cys Lys Leu Gly Val Thr Gly Leu Arg Cys Asn 
865                 870                 875                 880 


Gln Cys Glu Pro His Arg Tyr Asn Leu Thr Ile Asp Asn Phe Gln His 
                885                 890                 895     


Cys Gln Met Cys Glu Cys Asp Ser Leu Gly Thr Leu Pro Gly Thr Ile 
            900                 905                 910         


Cys Asp Pro Ile Ser Gly Gln Cys Leu Cys Val Pro Asn Arg Gln Gly 
        915                 920                 925             


Arg Arg Cys Asn Gln Cys Gln Pro Gly Phe Tyr Ile Ser Pro Gly Asn 
    930                 935                 940                 


Ala Thr Gly Cys Leu Pro Cys Ser Cys His Thr Thr Gly Ala Val Asn 
945                 950                 955                 960 


His Ile Cys Asn Ser Leu Thr Gly Gln Cys Val Cys Gln Asp Ala Ser 
                965                 970                 975     


Ile Ala Gly Gln Arg Cys Asp Gln Cys Lys Asp His Tyr Phe Gly Phe 
            980                 985                 990         


Asp Pro Gln Thr Gly Arg Cys Gln  Pro Cys Asn Cys His  Leu Ser Gly 
        995                 1000                 1005             


Ala Leu  Asn Glu Thr Cys His  Leu Val Thr Gly Gln  Cys Phe Cys 
    1010                 1015                 1020             


Lys Gln  Phe Val Thr Gly Ser  Lys Cys Asp Ala Cys  Val Pro Ser 
    1025                 1030                 1035             


Ala Ser  His Leu Asp Val Asn  Asn Leu Leu Gly Cys  Ser Lys Thr 
    1040                 1045                 1050             


Pro Phe  Gln Gln Pro Pro Pro  Arg Gly Gln Val Gln  Ser Ser Ser 
    1055                 1060                 1065             


Ala Ile  Asn Leu Ser Trp Ser  Pro Pro Asp Ser Pro  Asn Ala His 
    1070                 1075                 1080             


Trp Leu  Thr Tyr Ser Leu Leu  Arg Asp Gly Phe Glu  Ile Tyr Thr 
    1085                 1090                 1095             


Thr Glu  Asp Gln Tyr Pro Tyr  Ser Ile Gln Tyr Phe  Leu Asp Thr 
    1100                 1105                 1110             


Asp Leu  Leu Pro Tyr Thr Lys  Tyr Ser Tyr Tyr Ile  Glu Thr Thr 
    1115                 1120                 1125             


Asn Val  His Gly Ser Thr Arg  Ser Val Ala Val Thr  Tyr Lys Thr 
    1130                 1135                 1140             


Lys Pro  Gly Val Pro Glu Gly  Asn Leu Thr Leu Ser  Tyr Ile Ile 
    1145                 1150                 1155             


Pro Ile  Gly Ser Asp Ser Val  Thr Leu Thr Trp Thr  Thr Leu Ser 
    1160                 1165                 1170             


Asn Gln  Ser Gly Pro Ile Glu  Lys Tyr Ile Leu Ser  Cys Ala Pro 
    1175                 1180                 1185             


Leu Ala  Gly Gly Gln Pro Cys  Val Ser Tyr Glu Gly  His Glu Thr 
    1190                 1195                 1200             


Ser Ala  Thr Ile Trp Asn Leu  Val Pro Phe Ala Lys  Tyr Asp Phe 
    1205                 1210                 1215             


Ser Val  Gln Ala Cys Thr Ser  Gly Gly Cys Leu His  Ser Leu Pro 
    1220                 1225                 1230             


Ile Thr  Val Thr Thr Ala Gln  Ala Pro Pro Gln Arg  Leu Ser Pro 
    1235                 1240                 1245             


Pro Lys  Met Gln Lys Ile Ser  Ser Thr Glu Leu His  Val Glu Trp 
    1250                 1255                 1260             


Ser Pro  Pro Ala Glu Leu Asn  Gly Ile Ile Ile Arg  Tyr Glu Leu 
    1265                 1270                 1275             


Tyr Met  Arg Arg Leu Arg Ser  Thr Lys Glu Thr Thr  Ser Glu Glu 
    1280                 1285                 1290             


Ser Arg  Val Phe Gln Ser Ser  Gly Trp Leu Ser Pro  His Ser Phe 
    1295                 1300                 1305             


Val Glu  Ser Ala Asn Glu Asn  Ala Leu Lys Pro Pro  Gln Thr Met 
    1310                 1315                 1320             


Thr Thr  Ile Thr Gly Leu Glu  Pro Tyr Thr Lys Tyr  Glu Phe Arg 
    1325                 1330                 1335             


Val Leu  Ala Val Asn Met Ala  Gly Ser Val Ser Ser  Ala Trp Val 
    1340                 1345                 1350             


Ser Glu  Arg Thr Gly Glu Ser  Ala Pro Val Phe Met  Ile Pro Pro 
    1355                 1360                 1365             


Ser Val  Phe Pro Leu Ser Ser  Tyr Ser Leu Asn Ile  Ser Trp Glu 
    1370                 1375                 1380             


Lys Pro  Ala Asp Asn Val Thr  Arg Gly Lys Val Val  Gly Tyr Asp 
    1385                 1390                 1395             


Ile Asn  Met Leu Ser Glu Gln  Ser Pro Gln Gln Ser  Ile Pro Met 
    1400                 1405                 1410             


Ala Phe  Ser Gln Leu Leu His  Thr Ala Lys Ser Gln  Glu Leu Ser 
    1415                 1420                 1425             


Tyr Thr  Val Glu Gly Leu Lys  Pro Tyr Arg Ile Tyr  Glu Phe Thr 
    1430                 1435                 1440             


Ile Thr  Leu Cys Asn Ser Val  Gly Cys Val Thr Ser  Ala Ser Gly 
    1445                 1450                 1455             


Ala Gly  Gln Thr Leu Ala Ala  Ala Pro Ala Gln Leu  Arg Pro Pro 
    1460                 1465                 1470             


Leu Val  Lys Gly Ile Asn Ser  Thr Thr Ile His Leu  Lys Trp Phe 
    1475                 1480                 1485             


Pro Pro  Glu Glu Leu Asn Gly  Pro Ser Pro Ile Tyr  Gln Leu Glu 
    1490                 1495                 1500             


Arg Arg  Glu Ser Ser Leu Pro  Ala Leu Met Thr Thr  Met Met Lys 
    1505                 1510                 1515             


Gly Ile  Arg Phe Ile Gly Asn  Gly Tyr Cys Lys Phe  Pro Ser Ser 
    1520                 1525                 1530             


Thr His  Pro Val Asn Thr Asp  Phe Thr Gly Ile Lys  Ala Ser Phe 
    1535                 1540                 1545             


Arg Thr  Lys Val Pro Glu Gly  Leu Ile Val Phe Ala  Ala Ser Pro 
    1550                 1555                 1560             


Gly Asn  Gln Glu Glu Tyr Phe  Ala Leu Gln Leu Lys  Lys Gly Arg 
    1565                 1570                 1575             


Leu Tyr  Phe Leu Phe Asp Pro  Gln Gly Ser Pro Val  Glu Val Thr 
    1580                 1585                 1590             


Thr Thr  Asn Asp His Gly Lys  Gln Tyr Ser Asp Gly  Lys Trp His 
    1595                 1600                 1605             


Glu Ile  Ile Ala Ile Arg His  Gln Ala Phe Gly Gln  Ile Thr Leu 
    1610                 1615                 1620             


Asp Gly  Ile Tyr Thr Gly Ser  Ser Ala Ile Leu Asn  Gly Ser Thr 
    1625                 1630                 1635             


Val Ile  Gly Asp Asn Thr Gly  Val Phe Leu Gly Gly  Leu Pro Arg 
    1640                 1645                 1650             


Ser Tyr  Thr Ile Leu Arg Lys  Asp Pro Glu Ile Ile  Gln Lys Gly 
    1655                 1660                 1665             


Phe Val  Gly Cys Leu Lys Asp  Val His Phe Met Lys  Asn Tyr Asn 
    1670                 1675                 1680             


Pro Ser  Ala Ile Trp Glu Pro  Leu Asp Trp Gln Ser  Ser Glu Glu 
    1685                 1690                 1695             


Gln Ile  Asn Val Tyr Asn Ser  Trp Glu Gly Cys Pro  Ala Ser Leu 
    1700                 1705                 1710             


Asn Glu  Gly Ala Gln Phe Leu  Gly Ala Gly Phe Leu  Glu Leu His 
    1715                 1720                 1725             


Pro Tyr  Met Phe His Gly Gly  Met Asn Phe Glu Ile  Ser Phe Lys 
    1730                 1735                 1740             


Phe Arg  Thr Asp Gln Leu Asn  Gly Leu Leu Leu Phe  Val Tyr Asn 
    1745                 1750                 1755             


Lys Asp  Gly Pro Asp Phe Leu  Ala Met Glu Leu Lys  Ser Gly Ile 
    1760                 1765                 1770             


Leu Thr  Phe Arg Leu Asn Thr  Ser Leu Ala Phe Thr  Gln Val Asp 
    1775                 1780                 1785             


Leu Leu  Leu Gly Leu Ser Tyr  Cys Asn Gly Lys Trp  Asn Lys Val 
    1790                 1795                 1800             


Ile Ile  Lys Lys Glu Gly Ser  Phe Ile Ser Ala Ser  Val Asn Gly 
    1805                 1810                 1815             


Leu Met  Lys His Ala Ser Glu  Ser Gly Asp Gln Pro  Leu Val Val 
    1820                 1825                 1830             


Asn Ser  Pro Val Tyr Val Gly  Gly Ile Pro Gln Glu  Leu Leu Asn 
    1835                 1840                 1845             


Ser Tyr  Gln His Leu Cys Leu  Glu Gln Gly Phe Gly  Gly Cys Met 
    1850                 1855                 1860             


Lys Asp  Val Lys Phe Thr Arg  Gly Ala Val Val Asn  Leu Ala Ser 
    1865                 1870                 1875             


Val Ser  Ser Gly Ala Val Arg  Val Asn Leu Asp Gly  Cys Leu Ser 
    1880                 1885                 1890             


Thr Asp  Ser Ala Val Asn Cys  Arg Gly Asn Asp Ser  Ile Leu Val 
    1895                 1900                 1905             


Tyr Gln  Gly Lys Glu Gln Ser  Val Tyr Glu Gly Gly  Leu Gln Pro 
    1910                 1915                 1920             


Phe Thr  Glu Tyr Leu Tyr Arg  Val Ile Ala Ser His  Glu Gly Gly 
    1925                 1930                 1935             


Ser Val  Tyr Ser Asp Trp Ser  Arg Gly Arg Thr Thr  Gly Ala Ala 
    1940                 1945                 1950             


Pro Gln  Ser Val Pro Thr Pro  Ser Arg Val Arg Ser  Leu Asn Gly 
    1955                 1960                 1965             


Tyr Ser  Ile Glu Val Thr Trp  Asp Glu Pro Val Val  Arg Gly Val 
    1970                 1975                 1980             


Ile Glu  Lys Tyr Ile Leu Lys  Ala Tyr Ser Glu Asp  Ser Thr Arg 
    1985                 1990                 1995             


Pro Pro  Arg Met Pro Ser Ala  Ser Ala Glu Phe Val  Asn Thr Ser 
    2000                 2005                 2010             


Asn Leu  Thr Gly Ile Leu Thr  Gly Leu Leu Pro Phe  Lys Asn Tyr 
    2015                 2020                 2025             


Ala Val  Thr Leu Thr Ala Cys  Thr Leu Ala Gly Cys  Thr Glu Ser 
    2030                 2035                 2040             


Ser His  Ala Leu Asn Ile Ser  Thr Pro Gln Glu Ala  Pro Gln Glu 
    2045                 2050                 2055             


Val Gln  Pro Pro Val Ala Lys  Ser Leu Pro Ser Ser  Leu Leu Leu 
    2060                 2065                 2070             


Ser Trp  Asn Pro Pro Lys Lys  Ala Asn Gly Ile Ile  Thr Gln Tyr 
    2075                 2080                 2085             


Cys Leu  Tyr Met Asp Gly Arg  Leu Ile Tyr Ser Gly  Ser Glu Glu 
    2090                 2095                 2100             


Asn Tyr  Thr Val Thr Asp Leu  Ala Val Phe Thr Pro  His Gln Phe 
    2105                 2110                 2115             


Leu Leu  Ser Ala Cys Thr His  Val Gly Cys Thr Asn  Ser Ser Trp 
    2120                 2125                 2130             


Val Leu  Leu Tyr Thr Ala Gln  Leu Pro Pro Glu His  Val Asp Ser 
    2135                 2140                 2145             


Pro Val  Leu Thr Val Leu Asp  Ser Arg Thr Ile His  Ile Gln Trp 
    2150                 2155                 2160             


Lys Gln  Pro Arg Lys Ile Ser  Gly Ile Leu Glu Arg  Tyr Val Leu 
    2165                 2170                 2175             


Tyr Met  Ser Asn His Thr His  Asp Phe Thr Ile Trp  Ser Val Ile 
    2180                 2185                 2190             


Tyr Asn  Ser Thr Glu Leu Phe  Gln Asp His Met Leu  Gln Tyr Val 
    2195                 2200                 2205             


Leu Pro  Gly Asn Lys Tyr Leu  Ile Lys Leu Gly Ala  Cys Thr Gly 
    2210                 2215                 2220             


Gly Gly  Cys Thr Val Ser Glu  Ala Ser Glu Ala Leu  Thr Asp Glu 
    2225                 2230                 2235             


Asp Ile  Pro Glu Gly Val Pro  Ala Pro Lys Ala His  Ser Tyr Ser 
    2240                 2245                 2250             


Pro Asp  Ser Phe Asn Val Ser  Trp Thr Glu Pro Glu  Tyr Pro Asn 
    2255                 2260                 2265             


Gly Val  Ile Thr Ser Tyr Gly  Leu Tyr Leu Asp Gly  Ile Leu Ile 
    2270                 2275                 2280             


His Asn  Ser Ser Glu Leu Ser  Tyr Arg Ala Tyr Gly  Phe Ala Pro 
    2285                 2290                 2295             


Trp Ser  Leu His Ser Phe Arg  Val Gln Ala Cys Thr  Ala Lys Gly 
    2300                 2305                 2310             


Cys Ala  Leu Gly Pro Leu Val  Glu Asn Arg Thr Leu  Glu Ala Pro 
    2315                 2320                 2325             


Pro Glu  Gly Thr Val Asn Val  Phe Val Lys Thr Gln  Gly Ser Arg 
    2330                 2335                 2340             


Lys Ala  His Val Arg Trp Glu  Ala Pro Phe Arg Pro  Asn Gly Leu 
    2345                 2350                 2355             


Leu Thr  His Ser Val Leu Phe  Thr Gly Ile Phe Tyr  Val Asp Pro 
    2360                 2365                 2370             


Val Gly  Asn Asn Tyr Thr Leu  Leu Asn Val Thr Lys  Val Met Tyr 
    2375                 2380                 2385             


Ser Gly  Glu Glu Thr Asn Leu  Trp Val Leu Ile Asp  Gly Leu Val 
    2390                 2395                 2400             


Pro Phe  Thr Asn Tyr Thr Val  Gln Val Asn Ile Ser  Asn Ser Gln 
    2405                 2410                 2415             


Gly Ser  Leu Ile Thr Asp Pro  Ile Thr Ile Ala Met  Pro Pro Gly 
    2420                 2425                 2430             


Ala Pro  Asp Gly Val Leu Pro  Pro Arg Leu Ser Ser  Ala Thr Pro 
    2435                 2440                 2445             


Thr Ser  Leu Gln Val Val Trp  Ser Thr Pro Ala Arg  Asn Asn Ala 
    2450                 2455                 2460             


Pro Gly  Ser Pro Arg Tyr Gln  Leu Gln Met Arg Ser  Gly Asp Ser 
    2465                 2470                 2475             


Thr His  Gly Phe Leu Glu Leu  Phe Ser Asn Pro Ser  Ala Ser Leu 
    2480                 2485                 2490             


Ser Tyr  Glu Val Ser Asp Leu  Gln Pro Tyr Thr Glu  Tyr Met Phe 
    2495                 2500                 2505             


Arg Leu  Val Ala Ser Asn Gly  Phe Gly Ser Ala His  Ser Ser Trp 
    2510                 2515                 2520             


Ile Pro  Phe Met Thr Ala Glu  Asp Lys Pro Gly Pro  Val Val Pro 
    2525                 2530                 2535             


Pro Ile  Leu Leu Asp Val Lys  Ser Arg Met Met Leu  Val Thr Trp 
    2540                 2545                 2550             


Gln His  Pro Arg Lys Ser Asn  Gly Val Ile Thr His  Tyr Asn Ile 
    2555                 2560                 2565             


Tyr Leu  His Gly Arg Leu Tyr  Leu Arg Thr Pro Gly  Asn Val Thr 
    2570                 2575                 2580             


Asn Cys  Thr Val Met His Leu  His Pro Tyr Thr Ala  Tyr Lys Phe 
    2585                 2590                 2595             


Gln Val  Glu Ala Cys Thr Ser  Lys Gly Cys Ser Leu  Ser Pro Glu 
    2600                 2605                 2610             


Ser Gln  Thr Val Trp Thr Leu  Pro Gly Ala Pro Glu  Gly Ile Pro 
    2615                 2620                 2625             


Ser Pro  Glu Leu Phe Ser Asp  Thr Pro Thr Ser Val  Ile Ile Ser 
    2630                 2635                 2640             


Trp Gln  Pro Pro Thr His Pro  Asn Gly Leu Val Glu  Asn Phe Thr 
    2645                 2650                 2655             


Ile Glu  Arg Arg Val Lys Gly  Lys Glu Glu Val Thr  Thr Leu Val 
    2660                 2665                 2670             


Thr Leu  Pro Arg Ser His Ser  Met Arg Phe Ile Asp  Lys Thr Ser 
    2675                 2680                 2685             


Ala Leu  Ser Pro Trp Thr Lys  Tyr Glu Tyr Arg Val  Leu Met Ser 
    2690                 2695                 2700             


Thr Leu  His Gly Gly Thr Asn  Ser Ser Ala Trp Val  Glu Val Thr 
    2705                 2710                 2715             


Thr Arg  Pro Ser Arg Pro Ala  Gly Val Gln Pro Pro  Val Val Thr 
    2720                 2725                 2730             


Val Leu  Glu Pro Asp Ala Val  Gln Val Thr Trp Lys  Pro Pro Leu 
    2735                 2740                 2745             


Ile Gln  Asn Gly Asp Ile Leu  Ser Tyr Glu Ile His  Met Pro Asp 
    2750                 2755                 2760             


Pro His  Ile Thr Leu Thr Asn  Val Thr Ser Ala Val  Leu Ser Gln 
    2765                 2770                 2775             


Lys Val  Thr His Leu Ile Pro  Phe Thr Asn Tyr Ser  Val Thr Ile 
    2780                 2785                 2790             


Val Ala  Cys Ser Gly Gly Asn  Gly Tyr Leu Gly Gly  Cys Thr Glu 
    2795                 2800                 2805             


Ser Leu  Pro Thr Tyr Val Thr  Thr His Pro Thr Val  Pro Gln Asn 
    2810                 2815                 2820             


Val Gly  Pro Leu Ser Val Ile  Pro Leu Ser Glu Ser  Tyr Val Val 
    2825                 2830                 2835             


Ile Ser  Trp Gln Pro Pro Ser  Lys Pro Asn Gly Pro  Asn Leu Arg 
    2840                 2845                 2850             


Tyr Glu  Leu Leu Arg Arg Lys  Ile Gln Gln Pro Leu  Ala Ser Asn 
    2855                 2860                 2865             


Pro Pro  Glu Asp Leu Asn Arg  Trp His Asn Ile Tyr  Ser Gly Thr 
    2870                 2875                 2880             


Gln Trp  Leu Tyr Glu Asp Lys  Gly Leu Ser Arg Phe  Thr Thr Tyr 
    2885                 2890                 2895             


Glu Tyr  Met Leu Phe Val His  Asn Ser Val Gly Phe  Thr Pro Ser 
    2900                 2905                 2910             


Arg Glu  Val Thr Val Thr Thr  Leu Ala Gly Leu Pro  Glu Arg Gly 
    2915                 2920                 2925             


Ala Asn  Leu Thr Ala Ser Val  Leu Asn His Thr Ala  Ile Asp Val 
    2930                 2935                 2940             


Arg Trp  Ala Lys Pro Thr Val  Gln Asp Leu Gln Gly  Glu Val Glu 
    2945                 2950                 2955             


Tyr Tyr  Thr Leu Phe Trp Ser  Ser Ala Thr Ser Asn  Asp Ser Leu 
    2960                 2965                 2970             


Lys Ile  Leu Pro Asp Val Asn  Ser His Val Ile Gly  His Leu Lys 
    2975                 2980                 2985             


Pro Asn  Thr Glu Tyr Trp Ile  Phe Ile Ser Val Phe  Asn Gly Val 
    2990                 2995                 3000             


His Ser  Ile Asn Ser Ala Gly  Leu His Ala Thr Thr  Cys Asp Gly 
    3005                 3010                 3015             


Glu Pro  Gln Gly Met Leu Pro  Pro Glu Val Val Ile  Ile Asn Ser 
    3020                 3025                 3030             


Thr Ala  Val Arg Val Ile Trp  Thr Ser Pro Ser Asn  Pro Asn Gly 
    3035                 3040                 3045             


Val Val  Thr Glu Tyr Ser Ile  Tyr Val Asn Asn Lys  Leu Tyr Lys 
    3050                 3055                 3060             


Thr Gly  Met Asn Val Pro Gly  Ser Phe Ile Leu Arg  Asp Leu Ser 
    3065                 3070                 3075             


Pro Phe  Thr Ile Tyr Asp Ile  Gln Val Glu Val Cys  Thr Ile Tyr 
    3080                 3085                 3090             


Ala Cys  Val Lys Ser Asn Gly  Thr Gln Ile Thr Thr  Val Glu Asp 
    3095                 3100                 3105             


Thr Pro  Ser Asp Ile Pro Thr  Pro Thr Ile Arg Gly  Ile Thr Ser 
    3110                 3115                 3120             


Arg Ser  Leu Gln Ile Asp Trp  Val Ser Pro Arg Lys  Pro Asn Gly 
    3125                 3130                 3135             


Ile Ile  Leu Gly Tyr Asp Leu  Leu Trp Lys Thr Trp  Tyr Pro Cys 
    3140                 3145                 3150             


Ala Lys  Thr Gln Lys Leu Val  Gln Asp Gln Ser Asp  Glu Leu Cys 
    3155                 3160                 3165             


Lys Ala  Val Arg Cys Gln Lys  Pro Glu Ser Ile Cys  Gly His Ile 
    3170                 3175                 3180             


Cys Tyr  Ser Ser Glu Ala Lys  Val Cys Cys Asn Gly  Val Leu Tyr 
    3185                 3190                 3195             


Asn Pro  Lys Pro Gly His Arg  Cys Cys Glu Glu Lys  Tyr Ile Pro 
    3200                 3205                 3210             


Phe Val  Leu Asn Ser Thr Gly  Val Cys Cys Gly Gly  Arg Ile Gln 
    3215                 3220                 3225             


Glu Ala  Gln Pro Asn His Gln  Cys Cys Ser Gly Tyr  Tyr Ala Arg 
    3230                 3235                 3240             


Ile Leu  Pro Gly Glu Val Cys  Cys Pro Asp Glu Gln  His Asn Arg 
    3245                 3250                 3255             


Val Ser  Val Gly Ile Gly Asp  Ser Cys Cys Gly Arg  Met Pro Tyr 
    3260                 3265                 3270             


Ser Thr  Ser Gly Asn Gln Ile  Cys Cys Ala Gly Arg  Leu His Asp 
    3275                 3280                 3285             


Gly His  Gly Gln Lys Cys Cys  Gly Arg Gln Ile Val  Ser Asn Asp 
    3290                 3295                 3300             


Leu Glu  Cys Cys Gly Gly Glu  Glu Gly Val Val Tyr  Asn Arg Leu 
    3305                 3310                 3315             


Pro Gly  Met Phe Cys Cys Gly  Gln Asp Tyr Val Asn  Met Ser Asp 
    3320                 3325                 3330             


Thr Ile  Cys Cys Ser Ala Ser  Ser Gly Glu Ser Lys  Ala His Ile 
    3335                 3340                 3345             


Lys Lys  Asn Asp Pro Val Pro  Val Lys Cys Cys Glu  Thr Glu Leu 
    3350                 3355                 3360             


Ile Pro  Lys Ser Gln Lys Cys  Cys Asn Gly Val Gly  Tyr Asn Pro 
    3365                 3370                 3375             


Leu Lys  Tyr Val Cys Ser Asp  Lys Ile Ser Thr Gly  Met Met Met 
    3380                 3385                 3390             


Lys Glu  Thr Lys Glu Cys Arg  Ile Leu Cys Pro Ala  Ser Met Glu 
    3395                 3400                 3405             


Ala Thr  Glu His Cys Gly Arg  Cys Asp Phe Asn Phe  Thr Ser His 
    3410                 3415                 3420             


Ile Cys  Thr Val Ile Arg Gly  Ser His Asn Ser Thr  Gly Lys Ala 
    3425                 3430                 3435             


Ser Ile  Glu Glu Met Cys Ser  Ser Ala Glu Glu Thr  Ile His Thr 
    3440                 3445                 3450             


Gly Ser  Val Asn Thr Tyr Ser  Tyr Thr Asp Val Asn  Leu Lys Pro 
    3455                 3460                 3465             


Tyr Met  Thr Tyr Glu Tyr Arg  Ile Ser Ala Trp Asn  Ser Tyr Gly 
    3470                 3475                 3480             


Arg Gly  Leu Ser Lys Ala Val  Arg Ala Arg Thr Lys  Glu Asp Val 
    3485                 3490                 3495             


Pro Gln  Gly Val Ser Pro Pro  Thr Trp Thr Lys Ile  Asp Asn Leu 
    3500                 3505                 3510             


Glu Asp  Thr Ile Val Leu Asn  Trp Arg Lys Pro Ile  Gln Ser Asn 
    3515                 3520                 3525             


Gly Pro  Ile Ile Tyr Tyr Ile  Leu Leu Arg Asn Gly  Ile Glu Arg 
    3530                 3535                 3540             


Phe Arg  Gly Thr Ser Leu Ser  Phe Ser Asp Lys Glu  Gly Ile Gln 
    3545                 3550                 3555             


Pro Phe  Gln Glu Tyr Ser Tyr  Gln Leu Lys Ala Cys  Thr Val Ala 
    3560                 3565                 3570             


Gly Cys  Ala Thr Ser Ser Lys  Val Val Ala Ala Thr  Thr Gln Gly 
    3575                 3580                 3585             


Val Pro  Glu Ser Ile Leu Pro  Pro Ser Ile Thr Ala  Leu Ser Ala 
    3590                 3595                 3600             


Val Ala  Leu His Leu Ser Trp  Ser Val Pro Glu Lys  Ser Asn Gly 
    3605                 3610                 3615             


Val Ile  Lys Glu Tyr Gln Ile  Arg Gln Val Gly Lys  Gly Leu Ile 
    3620                 3625                 3630             


His Thr  Asp Thr Thr Asp Arg  Arg Gln His Thr Val  Thr Gly Leu 
    3635                 3640                 3645             


Gln Pro  Tyr Thr Asn Tyr Ser  Phe Thr Leu Thr Ala  Cys Thr Ser 
    3650                 3655                 3660             


Ala Gly  Cys Thr Ser Ser Glu  Pro Phe Leu Gly Gln  Thr Leu Gln 
    3665                 3670                 3675             


Ala Ala  Pro Glu Gly Val Trp  Val Thr Pro Arg His  Ile Ile Ile 
    3680                 3685                 3690             


Asn Ser  Thr Thr Val Glu Leu  Tyr Trp Ser Leu Pro  Glu Lys Pro 
    3695                 3700                 3705             


Asn Gly  Leu Val Ser Gln Tyr  Gln Leu Ser Arg Asn  Gly Asn Leu 
    3710                 3715                 3720             


Leu Phe  Leu Gly Gly Ser Glu  Glu Gln Asn Phe Thr  Asp Lys Asn 
    3725                 3730                 3735             


Leu Glu  Pro Asn Ser Arg Tyr  Thr Tyr Lys Leu Glu  Val Lys Thr 
    3740                 3745                 3750             


Gly Gly  Gly Ser Ser Ala Ser  Asp Asp Tyr Ile Val  Gln Thr Pro 
    3755                 3760                 3765             


Met Ser  Thr Pro Glu Glu Ile  Tyr Pro Pro Tyr Asn  Ile Thr Val 
    3770                 3775                 3780             


Ile Gly  Pro Tyr Ser Ile Phe  Val Ala Trp Ile Pro  Pro Gly Ile 
    3785                 3790                 3795             


Leu Ile  Pro Glu Ile Pro Val  Glu Tyr Asn Val Leu  Leu Asn Asp 
    3800                 3805                 3810             


Gly Ser  Val Thr Pro Leu Ala  Phe Ser Val Gly His  His Gln Ser 
    3815                 3820                 3825             


Thr Leu  Leu Glu Asn Leu Thr  Pro Phe Thr Gln Tyr  Glu Ile Arg 
    3830                 3835                 3840             


Ile Gln  Ala Cys Gln Asn Gly  Ser Cys Gly Val Ser  Ser Arg Met 
    3845                 3850                 3855             


Phe Val  Lys Thr Pro Glu Ala  Ala Pro Met Asp Leu  Asn Ser Pro 
    3860                 3865                 3870             


Val Leu  Lys Ala Leu Gly Ser  Ala Cys Ile Glu Ile  Lys Trp Met 
    3875                 3880                 3885             


Pro Pro  Glu Lys Pro Asn Gly  Ile Ile Ile Asn Tyr  Phe Ile Tyr 
    3890                 3895                 3900             


Arg Arg  Pro Ala Gly Ile Glu  Glu Glu Ser Val Leu  Phe Val Trp 
    3905                 3910                 3915             


Ser Glu  Gly Ala Leu Glu Phe  Met Asp Glu Gly Asp  Thr Leu Arg 
    3920                 3925                 3930             


Pro Phe  Thr Leu Tyr Glu Tyr  Arg Val Arg Ala Cys  Asn Ser Lys 
    3935                 3940                 3945             


Gly Ser  Val Glu Ser Leu Trp  Ser Leu Thr Gln Thr  Leu Glu Ala 
    3950                 3955                 3960             


Pro Pro  Gln Asp Phe Pro Ala  Pro Trp Ala Gln Ala  Thr Ser Ala 
    3965                 3970                 3975             


His Ser  Val Leu Leu Asn Trp  Thr Lys Pro Glu Ser  Pro Asn Gly 
    3980                 3985                 3990             


Ile Ile  Ser His Tyr Arg Val  Val Tyr Gln Glu Arg  Pro Asp Asp 
    3995                 4000                 4005             


Pro Thr  Phe Asn Ser Pro Thr  Val His Ala Phe Thr  Val Lys Gly 
    4010                 4015                 4020             


Thr Ser  His Gln Ala His Leu  Tyr Gly Leu Glu Pro  Phe Thr Thr 
    4025                 4030                 4035             


Tyr Arg  Ile Gly Val Val Ala  Ala Asn His Ala Gly  Glu Ile Leu 
    4040                 4045                 4050             


Ser Pro  Trp Thr Leu Ile Gln  Thr Leu Glu Ser Ser  Pro Ser Gly 
    4055                 4060                 4065             


Leu Arg  Asn Phe Ile Val Glu  Gln Lys Glu Asn Gly  Arg Ala Leu 
    4070                 4075                 4080             


Leu Leu  Gln Trp Ser Glu Pro  Met Arg Thr Asn Gly  Val Ile Lys 
    4085                 4090                 4095             


Thr Tyr  Asn Ile Phe Ser Asp  Gly Phe Leu Glu Tyr  Ser Gly Leu 
    4100                 4105                 4110             


Asn Arg  Gln Phe Leu Phe Arg  Arg Leu Asp Pro Phe  Thr Leu Tyr 
    4115                 4120                 4125             


Thr Leu  Thr Leu Glu Ala Cys  Thr Arg Ala Gly Cys  Ala His Ser 
    4130                 4135                 4140             


Ala Pro  Gln Pro Leu Trp Thr  Asp Glu Ala Pro Pro  Asp Ser Gln 
    4145                 4150                 4155             


Leu Ala  Pro Thr Val His Ser  Val Lys Ser Thr Ser  Val Glu Leu 
    4160                 4165                 4170             


Ser Trp  Ser Glu Pro Val Asn  Pro Asn Gly Lys Ile  Ile Arg Tyr 
    4175                 4180                 4185             


Glu Val  Ile Arg Arg Cys Phe  Glu Gly Lys Ala Trp  Gly Asn Gln 
    4190                 4195                 4200             


Thr Ile  Gln Ala Asp Glu Lys  Ile Val Phe Thr Glu  Tyr Asn Thr 
    4205                 4210                 4215             


Glu Arg  Asn Thr Phe Met Tyr  Asn Asp Thr Gly Leu  Gln Pro Trp 
    4220                 4225                 4230             


Thr Gln  Cys Glu Tyr Lys Ile  Tyr Thr Trp Asn Ser  Ala Gly His 
    4235                 4240                 4245             


Thr Cys  Ser Ser Trp Asn Val  Val Arg Thr Leu Gln  Ala Pro Pro 
    4250                 4255                 4260             


Glu Gly  Leu Ser Pro Pro Val  Ile Ser Tyr Val Ser  Met Asn Pro 
    4265                 4270                 4275             


Gln Lys  Leu Leu Ile Ser Trp  Ile Pro Pro Glu Gln  Ser Asn Gly 
    4280                 4285                 4290             


Ile Ile  Gln Ser Tyr Arg Leu  Gln Arg Asn Glu Met  Leu Tyr Pro 
    4295                 4300                 4305             


Phe Ser  Phe Asp Pro Val Thr  Phe Asn Tyr Thr Asp  Glu Glu Leu 
    4310                 4315                 4320             


Leu Pro  Phe Ser Thr Tyr Ser  Tyr Ala Leu Gln Ala  Cys Thr Ser 
    4325                 4330                 4335             


Gly Gly  Cys Ser Thr Ser Lys  Pro Thr Ser Ile Thr  Thr Leu Glu 
    4340                 4345                 4350             


Ala Ala  Pro Ser Glu Val Ser  Pro Pro Asp Leu Trp  Ala Val Ser 
    4355                 4360                 4365             


Ala Thr  Gln Met Asn Val Cys  Trp Ser Pro Pro Thr  Val Gln Asn 
    4370                 4375                 4380             


Gly Lys  Ile Thr Lys Tyr Leu  Val Arg Tyr Asp Asn  Lys Glu Ser 
    4385                 4390                 4395             


Leu Ala  Gly Gln Gly Leu Cys  Leu Leu Val Ser His  Leu Gln Pro 
    4400                 4405                 4410             


Tyr Ser  Gln Tyr Asn Phe Ser  Leu Val Ala Cys Thr  Asn Gly Gly 
    4415                 4420                 4425             


Cys Thr  Ala Ser Val Ser Lys  Ser Ala Trp Thr Met  Glu Ala Leu 
    4430                 4435                 4440             


Pro Glu  Asn Met Asp Ser Pro  Thr Leu Gln Val Thr  Gly Ser Glu 
    4445                 4450                 4455             


Ser Ile  Glu Ile Thr Trp Lys  Pro Pro Arg Asn Pro  Asn Gly Gln 
    4460                 4465                 4470             


Ile Arg  Ser Tyr Glu Leu Arg  Arg Asp Gly Thr Ile  Val Tyr Thr 
    4475                 4480                 4485             


Gly Leu  Glu Thr Arg Tyr Arg  Asp Phe Thr Leu Thr  Pro Gly Val 
    4490                 4495                 4500             


Glu Tyr  Ser Tyr Thr Val Thr  Ala Ser Asn Ser Gln  Gly Gly Ile 
    4505                 4510                 4515             


Leu Ser  Pro Leu Val Lys Asp  Arg Thr Ser Pro Ser  Ala Pro Ser 
    4520                 4525                 4530             


Gly Met  Glu Pro Pro Lys Leu  Gln Ala Arg Gly Pro  Gln Glu Ile 
    4535                 4540                 4545             


Leu Val  Asn Trp Asp Pro Pro  Val Arg Thr Asn Gly  Asp Ile Ile 
    4550                 4555                 4560             


Asn Tyr  Thr Leu Phe Ile Arg  Glu Leu Phe Glu Arg  Glu Thr Lys 
    4565                 4570                 4575             


Ile Ile  His Ile Asn Thr Thr  His Asn Ser Phe Gly  Met Gln Ser 
    4580                 4585                 4590             


Tyr Ile  Val Asn Gln Leu Lys  Pro Phe His Arg Tyr  Glu Ile Arg 
    4595                 4600                 4605             


Ile Gln  Ala Cys Thr Thr Leu  Gly Cys Ala Ser Ser  Asp Trp Thr 
    4610                 4615                 4620             


Phe Ile  Gln Thr Pro Glu Ile  Ala Pro Leu Met Gln  Pro Pro Pro 
    4625                 4630                 4635             


His Leu  Glu Val Gln Met Ala  Pro Gly Gly Phe Gln  Pro Thr Val 
    4640                 4645                 4650             


Ser Leu  Leu Trp Thr Gly Pro  Leu Gln Pro Asn Gly  Lys Val Leu 
    4655                 4660                 4665             


Tyr Tyr  Glu Leu Tyr Arg Arg  Gln Ile Ala Thr Gln  Pro Arg Lys 
    4670                 4675                 4680             


Ser Asn  Pro Val Leu Ile Tyr  Asn Gly Ser Ser Thr  Ser Phe Ile 
    4685                 4690                 4695             


Asp Ser  Glu Leu Leu Pro Phe  Thr Glu Tyr Glu Tyr  Gln Val Trp 
    4700                 4705                 4710             


Ala Val  Asn Ser Ala Gly Lys  Ala Pro Ser Ser Trp  Thr Trp Cys 
    4715                 4720                 4725             


Arg Thr  Gly Pro Ala Pro Pro  Glu Gly Leu Arg Ala  Pro Thr Phe 
    4730                 4735                 4740             


His Val  Ile Ser Ser Thr Gln  Ala Val Val Asn Ile  Ser Ala Pro 
    4745                 4750                 4755             


Gly Lys  Pro Asn Gly Ile Val  Ser Leu Tyr Arg Leu  Phe Ser Ser 
    4760                 4765                 4770             


Ser Ala  His Gly Ala Glu Thr  Val Leu Ser Glu Gly  Met Ala Thr 
    4775                 4780                 4785             


Gln Gln  Thr Leu His Gly Leu  Gln Ala Phe Thr Asn  Tyr Ser Ile 
    4790                 4795                 4800             


Gly Val  Glu Ala Cys Thr Cys  Phe Asn Cys Cys Ser  Lys Gly Pro 
    4805                 4810                 4815             


Thr Ala  Glu Leu Arg Thr His  Pro Ala Pro Pro Ser  Gly Leu Ser 
    4820                 4825                 4830             


Ser Pro  Gln Ile Gly Thr Leu  Ala Ser Arg Thr Ala  Ser Phe Arg 
    4835                 4840                 4845             


Trp Ser  Pro Pro Met Phe Pro  Asn Gly Val Ile His  Ser Tyr Glu 
    4850                 4855                 4860             


Leu Gln  Phe His Val Ala Cys  Pro Pro Asp Ser Ala  Leu Pro Cys 
    4865                 4870                 4875             


Thr Pro  Ser Gln Ile Glu Thr  Lys Tyr Thr Gly Leu  Gly Gln Lys 
    4880                 4885                 4890             


Ala Ser  Leu Gly Gly Leu Gln  Pro Tyr Thr Thr Tyr  Lys Leu Arg 
    4895                 4900                 4905             


Val Val  Ala His Asn Glu Val  Gly Ser Thr Ala Ser  Glu Trp Ile 
    4910                 4915                 4920             


Ser Phe  Thr Thr Gln Lys Glu  Leu Pro Gln Tyr Arg  Ala Pro Phe 
    4925                 4930                 4935             


Ser Val  Asp Ser Asn Leu Ser  Val Val Cys Val Asn  Trp Ser Asp 
    4940                 4945                 4950             


Thr Phe  Leu Leu Asn Gly Gln  Leu Lys Glu Tyr Val  Leu Thr Asp 
    4955                 4960                 4965             


Gly Gly  Arg Arg Val Tyr Ser  Gly Leu Asp Thr Thr  Leu Tyr Ile 
    4970                 4975                 4980             


Pro Arg  Thr Ala Asp Lys Thr  Phe Phe Phe Gln Val  Ile Cys Thr 
    4985                 4990                 4995             


Thr Asp  Glu Gly Ser Val Lys  Thr Pro Leu Ile Gln  Tyr Asp Thr 
    5000                 5005                 5010             


Ser Thr  Gly Leu Gly Leu Val  Leu Thr Thr Pro Gly  Lys Lys Lys 
    5015                 5020                 5025             


Gly Ser  Arg Ser Lys Ser Thr  Glu Phe Tyr Ser Glu  Leu Trp Phe 
    5030                 5035                 5040             


Ile Val  Leu Met Ala Met Leu  Gly Leu Ile Leu Leu  Ala Ile Phe 
    5045                 5050                 5055             


Leu Ser  Leu Ile Leu Gln Arg  Lys Ile His Lys Glu  Pro Tyr Ile 
    5060                 5065                 5070             


Arg Glu  Arg Pro Pro Leu Val  Pro Leu Gln Lys Arg  Met Ser Pro 
    5075                 5080                 5085             


Leu Asn  Val Tyr Pro Pro Gly  Glu Asn His Met Gly  Leu Ala Asp 
    5090                 5095                 5100             


Thr Lys  Ile Pro Arg Ser Gly  Thr Pro Val Ser Ile  Arg Ser Asn 
    5105                 5110                 5115             


Arg Ser  Ala Cys Val Leu Arg  Ile Pro Ser Gln Asn  Gln Thr Ser 
    5120                 5125                 5130             


Leu Thr  Tyr Ser Gln Gly Ser  Leu His Arg Ser Val  Ser Gln Leu 
    5135                 5140                 5145             


Met Asp  Ile Gln Asp Lys Lys  Val Leu Met Asp Asn  Ser Leu Trp 
    5150                 5155                 5160             


Glu Ala  Ile Met Gly His Asn  Ser Gly Leu Tyr Val  Asp Glu Glu 
    5165                 5170                 5175             


Asp Leu  Met Asn Ala Ile Lys  Asp Phe Ser Ser Val  Thr Lys Glu 
    5180                 5185                 5190             


Arg Thr  Thr Phe Thr Asp Thr  His Leu 
    5195                 5200         


<210>  157
<211>  6576
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (167)..(2320)

<400>  157
gcggccgcgg cggcggggag agcggaggga gcgccgcccg cccgcgccgt cctttgtgtg       60

gcggcggcgg cgcctgggcc tgaccgggtc cccggggctg agcgccgggc tccgcgccgc      120

ccctcccgcg cccctgccaa gcgggcgcct atcctctccg agcaag atg gca acc         175
                                                   Met Ala Thr            
                                                   1                      

ccg gcg gcg gtc aac cct ccg gaa atg gct tca gac ata cct gga tct        223
Pro Ala Ala Val Asn Pro Pro Glu Met Ala Ser Asp Ile Pro Gly Ser           
    5                   10                  15                            

gtg acg ttg ccc gtt gcc ccc atg gcg gcc acc gga cag gtg agg atg        271
Val Thr Leu Pro Val Ala Pro Met Ala Ala Thr Gly Gln Val Arg Met           
20                  25                  30                  35            

gcg ggg gcc atg cct gcc cgt gga gga aag cgg cgt tcc gga atg gac        319
Ala Gly Ala Met Pro Ala Arg Gly Gly Lys Arg Arg Ser Gly Met Asp           
                40                  45                  50                

ttc gat gat gaa gat ggt gaa ggc ccc agt aaa ttt tca aga gag aat        367
Phe Asp Asp Glu Asp Gly Glu Gly Pro Ser Lys Phe Ser Arg Glu Asn           
            55                  60                  65                    

cat agt gaa atc gaa agg cgc aga cgg aac aag atg act cag tac atc        415
His Ser Glu Ile Glu Arg Arg Arg Arg Asn Lys Met Thr Gln Tyr Ile           
        70                  75                  80                        

acg gag ctc tcc gac atg gtc ccc aca tgc agc gca ctg gct cgg aag        463
Thr Glu Leu Ser Asp Met Val Pro Thr Cys Ser Ala Leu Ala Arg Lys           
    85                  90                  95                            

cca gac aag ctc acc atc ctc cgc atg gcc gtc tcg cac atg aag tcc        511
Pro Asp Lys Leu Thr Ile Leu Arg Met Ala Val Ser His Met Lys Ser           
100                 105                 110                 115           

atg agg ggt aca ggg aac aag tcc acc gat ggc gcg tac aag cct tcc        559
Met Arg Gly Thr Gly Asn Lys Ser Thr Asp Gly Ala Tyr Lys Pro Ser           
                120                 125                 130               

ttc ctc aca gag cag gaa ctg aag cat ctc atc ctt gaa gca gct gat        607
Phe Leu Thr Glu Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp           
            135                 140                 145                   

gga ttt ctg ttt gtg gtg gct gct gag aca ggg cga gtg att tat gtg        655
Gly Phe Leu Phe Val Val Ala Ala Glu Thr Gly Arg Val Ile Tyr Val           
        150                 155                 160                       

tct gac tcc gtc acc cct gtt ctg aac cag ccc cag tca gag tgg ttt        703
Ser Asp Ser Val Thr Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe           
    165                 170                 175                           

ggg agc aca ctg tat gaa cag gtg cat cct gat gac gtg gag aag ctg        751
Gly Ser Thr Leu Tyr Glu Gln Val His Pro Asp Asp Val Glu Lys Leu           
180                 185                 190                 195           

aga gag caa ctg tgc acc tca gaa aac tca atg aca ggc cgg atc ttg        799
Arg Glu Gln Leu Cys Thr Ser Glu Asn Ser Met Thr Gly Arg Ile Leu           
                200                 205                 210               

gac ctg aag act ggg acg gtc aag aaa gaa ggg cag cag tca tcc atg        847
Asp Leu Lys Thr Gly Thr Val Lys Lys Glu Gly Gln Gln Ser Ser Met           
            215                 220                 225                   

agg atg tgc atg ggc tcg cgg cgg tct ttc atc tgc agg atg agg tgt        895
Arg Met Cys Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys           
        230                 235                 240                       

gga aat gct cct ttg gac cac ctt cct cta aac aga ata acc acc atg        943
Gly Asn Ala Pro Leu Asp His Leu Pro Leu Asn Arg Ile Thr Thr Met           
    245                 250                 255                           

agg aaa agg ttc agg aat ggc ctt ggc cct gtg aaa gaa gga gaa gcc        991
Arg Lys Arg Phe Arg Asn Gly Leu Gly Pro Val Lys Glu Gly Glu Ala           
260                 265                 270                 275           

caa tat gct gtg gtc cac tgt aca gga tac atc aag gcc tgg cca cca       1039
Gln Tyr Ala Val Val His Cys Thr Gly Tyr Ile Lys Ala Trp Pro Pro           
                280                 285                 290               

gca gga atg acc ata cct gaa gaa gac gct gat gtg gga caa ggc agt       1087
Ala Gly Met Thr Ile Pro Glu Glu Asp Ala Asp Val Gly Gln Gly Ser           
            295                 300                 305                   

aaa tat tgc ctc gtg gca att ggg aga ctc cag gtg acc agc tct cct       1135
Lys Tyr Cys Leu Val Ala Ile Gly Arg Leu Gln Val Thr Ser Ser Pro           
        310                 315                 320                       

gta tgc atg gac atg aat ggg atg tcg gtg ccc aca gag ttc tta tcc       1183
Val Cys Met Asp Met Asn Gly Met Ser Val Pro Thr Glu Phe Leu Ser           
    325                 330                 335                           

cgg cat aac tcc gat gga atc atc aca ttt gtg gat cca aga tgt atc       1231
Arg His Asn Ser Asp Gly Ile Ile Thr Phe Val Asp Pro Arg Cys Ile           
340                 345                 350                 355           

agt gtg att ggc tac caa ccc cag gat ctt ctg gga aag gac att ttg       1279
Ser Val Ile Gly Tyr Gln Pro Gln Asp Leu Leu Gly Lys Asp Ile Leu           
                360                 365                 370               

gaa ttc tgc cac cct gag gat caa agc cat ctg cgt gag agc ttc cag       1327
Glu Phe Cys His Pro Glu Asp Gln Ser His Leu Arg Glu Ser Phe Gln           
            375                 380                 385                   

cag gtg gtt aag ctg aaa ggc caa gtc ctg tcg gtc atg tat cga ttt       1375
Gln Val Val Lys Leu Lys Gly Gln Val Leu Ser Val Met Tyr Arg Phe           
        390                 395                 400                       

cgc acc aag aac cgg gag tgg atg ttg atc cgc acc agc agc ttc aca       1423
Arg Thr Lys Asn Arg Glu Trp Met Leu Ile Arg Thr Ser Ser Phe Thr           
    405                 410                 415                           

ttc cag aat ccc tat tct gat gag att gag tac atc atc tgc acc aac       1471
Phe Gln Asn Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile Cys Thr Asn           
420                 425                 430                 435           

acc aac gtc aag caa ctt cag caa cag cag gca gaa ttg gaa gtg cac       1519
Thr Asn Val Lys Gln Leu Gln Gln Gln Gln Ala Glu Leu Glu Val His           
                440                 445                 450               

cag aga gat gga ttg tca tcg tat gac tta tcc cag gtc ccc gtc ccc       1567
Gln Arg Asp Gly Leu Ser Ser Tyr Asp Leu Ser Gln Val Pro Val Pro           
            455                 460                 465                   

aac cta cca gcc ggt gtt cat gag gcc ggg aag tcc gtg gaa aag gcg       1615
Asn Leu Pro Ala Gly Val His Glu Ala Gly Lys Ser Val Glu Lys Ala           
        470                 475                 480                       

gat gca atc ttc tcc cag gaa aga gat cct cgg ttt gct gaa atg ttt       1663
Asp Ala Ile Phe Ser Gln Glu Arg Asp Pro Arg Phe Ala Glu Met Phe           
    485                 490                 495                           

gca gga att agt gca tcg gag aag aag atg atg agc tca gcc tct gca       1711
Ala Gly Ile Ser Ala Ser Glu Lys Lys Met Met Ser Ser Ala Ser Ala           
500                 505                 510                 515           

gca gga acc cag cag atc tac tcc caa gga agc cca ttt ccc tct gga       1759
Ala Gly Thr Gln Gln Ile Tyr Ser Gln Gly Ser Pro Phe Pro Ser Gly           
                520                 525                 530               

cac tcc ggg aag gcc ttc agc tct tca gtg gtt cat gtg cct gga gtg       1807
His Ser Gly Lys Ala Phe Ser Ser Ser Val Val His Val Pro Gly Val           
            535                 540                 545                   

aat gat att cag tcc tct tct tcc acg ggc cag aac atg tcc caa atc       1855
Asn Asp Ile Gln Ser Ser Ser Ser Thr Gly Gln Asn Met Ser Gln Ile           
        550                 555                 560                       

tcc cgg cag cta aac cag agt cag gtg gca tgg aca ggg agt cgt ccg       1903
Ser Arg Gln Leu Asn Gln Ser Gln Val Ala Trp Thr Gly Ser Arg Pro           
    565                 570                 575                           

ccc ttt ccg gga cag caa atc cca tct cag tcc agc aag act cag tca       1951
Pro Phe Pro Gly Gln Gln Ile Pro Ser Gln Ser Ser Lys Thr Gln Ser           
580                 585                 590                 595           

tct ccc ttt ggg att gga acg agc cac acc tac ccg gca gac ccc tct       1999
Ser Pro Phe Gly Ile Gly Thr Ser His Thr Tyr Pro Ala Asp Pro Ser           
                600                 605                 610               

tcc tac agc ccc ctc tcc agc cca gct acc tcc tcg cca agt ggg aat       2047
Ser Tyr Ser Pro Leu Ser Ser Pro Ala Thr Ser Ser Pro Ser Gly Asn           
            615                 620                 625                   

gcc tac tcc agt ctt gcc aac agg act cca ggg ttc gct gaa agt gga       2095
Ala Tyr Ser Ser Leu Ala Asn Arg Thr Pro Gly Phe Ala Glu Ser Gly           
        630                 635                 640                       

caa agt agc ggg cag ttc caa ggg cgg ccc tcg gaa gtc tgg tcg cag       2143
Gln Ser Ser Gly Gln Phe Gln Gly Arg Pro Ser Glu Val Trp Ser Gln           
    645                 650                 655                           

tgg caa agc cag cac cat ggc cag cag agc ggt gag cag cac tcc cac       2191
Trp Gln Ser Gln His His Gly Gln Gln Ser Gly Glu Gln His Ser His           
660                 665                 670                 675           

cag cag ccc ggt cag act gaa gtg ttc cag gac atg ctg ccc atg cca       2239
Gln Gln Pro Gly Gln Thr Glu Val Phe Gln Asp Met Leu Pro Met Pro           
                680                 685                 690               

gga gat cca acc cag ggg act ggc aac tat aac atc gaa gac ttt gcc       2287
Gly Asp Pro Thr Gln Gly Thr Gly Asn Tyr Asn Ile Glu Asp Phe Ala           
            695                 700                 705                   

gac ctg ggc atg ttt cca ccg ttt tct gag tag ctgcggccag agtgaggctc     2340
Asp Leu Gly Met Phe Pro Pro Phe Ser Glu                                   
        710                 715                                           

ctgctgtaca gtgccaccca tactgtgatg tcgatgccca tgtgaatgag gcccaccctc     2400

gccctgcttg ccctgccgca ggccccccac cagaagccat ctcccccgct gtgtgtcccc     2460

aggcgcatca ttgctccact ctcccctgca gccgcggctg ctcggccact gaccaggggc     2520

cctggcagac attaggggat cagttgtatt tattgtattt tatctgtgtg tgctcaggag     2580

gtgagcctag tgggtcctta agtttggttg tgaataatct cttgatagac aatttatacc     2640

catgaaagtt cagccaatgc ccagagtgac caagcagcac cagcaggcct gcccaggatg     2700

ctgaaagcag atttcttctt gatttcactt ctgatggatg catggggctc tgggggaatg     2760

ctgggaaaat gggcaagcag agtgcacagc cctcgttctg ccagctggag ccaagaagca     2820

cagagacaca gaggcgcctg cccctcagct ccgctggtct gtctgtgcat ccactgtgcc     2880

gtgggacata tgtaatttgt gcagtgtgac atggacttgc tgtcctaatg gatgtgttgt     2940

gccttgtgtc tgtcatgtgt ggccagcgtg attgtataga atccagagta tgtagagagc     3000

caaaatgtgt ggccctgtcc ccaagctcag caccaccggc catgaccaga ggttgctcgg     3060

cccagggtct gggagctggg ctaacaggct gacacttcgg cagggtcacc aggaggcaca     3120

gctaggggca tgctcacatg ggtaggtcag ttctttggtc caagcctctg gtgcagattc     3180

aagctcctcc tcttagagga agcagctcct tcctcccaca ggagccccaa gggagcactc     3240

accctcctcc caattggatc tgaatagctg tgttcctgat cccacataag catgtctcat     3300

ccttgcccca ctggtgagag gaggaccttg tgcctgccca gagcctgcag gacagcacgc     3360

cttgaggtca gaggcctggc ccttctttac agatgtagat agcagggtag gacgcccagg     3420

ccttctcaca tgggcaccat gaaacacttt cttccaggcc acctgagcct tcgttcttca     3480

gcccgactgg aggaacagca gctctgggag gcacagagtg caggtctcag gggcagaaga     3540

catgggttcc agttctggtt ctgccacaca cccaccggcc ttgaatttct ctggtggtct     3600

caagacaaga acaagagctg actctagaat cttctgcctg gctgacctct gagcccatga     3660

tccctggctt gctgtgcttc tcttggattt gaggagagtt tatgaatcca tccccctgtt     3720

ttcagggacc tctgccttct cccacacccc ttacactagt gaggactcct tcggcctctt     3780

gtgtttcctt ccttttgtga ccattacgcc ccctccctgt ttcttatcac cagcccatca     3840

gcccactgac tcccatatgg tagaaaaggt accgtggctg ctgcagggca catggaggga     3900

cctaccctct gggaaagccc ttgtgtccct cccagagtcc ttcaggtagg ccctcgcaga     3960

tgctgcttgc tcagaaacaa cccgtgcatc cctgcccatg gattctgcag gacctagaag     4020

agtggcattg gttctaggaa cctgagagtg gagtgaggcc agcatgcagg aaggagtttg     4080

gagagagtgt ttgctgtgat ccattgaaag ctccacatta aaccccagcc ctgtctggcc     4140

agggagatcc atgtgctcaa tgttgctggg ggacctacaa aagtcaaaca ttgctcagta     4200

aaatgccttt ggctggtcgc cagctgtgca tgactgcagt tcctagactc taacttaacc     4260

ccaactttgc agtttctaga gctttttgtc tgtaatggtg attgggtctc cactgtagat     4320

gcatgcagtg ttcactccaa cctcagaggc tttcttgctt ctggggaaat ggcaggtggt     4380

tgaaaccctg cacatcctcc cagggccagc cccagaatgg gcctttctct gcctgccctg     4440

cccttggggc cacctctgcc tccagcaggc ttgagcttgc cccaggcctt gggcataatt     4500

atttcccccc aaaaaaggca caaaaatagg ttttggatca aagaagtgtt tctcagtgaa     4560

atgaaaacag tctttttata gcctttagct tgtgagtttg gaagtttggg gggtcttatg     4620

tttgttttgc ctcttctgtt tcttggagga gagttgaggc ttttcttagg tgcatacaca     4680

gacccaggtg aacacgctga ctgtgaacct gccctgtatc cggagctgtg ctgggcactg     4740

aggggatgca acaaaattag gagaggatcc ttgctcccaa cgtctacttc tcctacctca     4800

acaggggtcc agggtgcagt gaactcagtt cttggccctt gggtgaggat tcatggatga     4860

atgaaagcta gacctgatgg ggaggcatta tgactaaata ggcccagcct ccttcccttc     4920

cagctctgtc ctaggagcat aggcgggaaa tctgagtaga gtctgactgc agtttttgct     4980

tatgatttgt aaaagccgtc atggggtcaa taagaaaata ggggtgatgg agggggagaa     5040

gcccaggact gggagaatcg cacatgcccc aggggttttc accaaggatt ttcaagacaa     5100

actggagtaa gaattaaagc cccagaggat ttaattatcc tggtttgcaa aagagcctcc     5160

catgccagta ccgcccagcc ttggaggccg gaatgctcat ggcccctgtg gtctgcttgt     5220

ccttcagccc atgcccagca gatacctctc tgactggaga cgggctcaaa gctggattag     5280

aaaggggaga ggcacttgtg actttgtttg actctgtgac tcacttcctc gctcacacct     5340

tgtttgaact actggacttt caactggctt tccttaggtc aggcaagcag acagctcccc     5400

actgaagagg tctgtacagt gacaacccgg gccggcagca aggacacaga tgcagccaca     5460

gtaaggctcc atcaggactg ggtcagtgat ggcaacagga tggccaagga tggctctaga     5520

acactctgtc catgcgtcac tccccccagt tttattttta gctttggctt cagggagtga     5580

cagccatcac aaatagccac attctgctct actctccaac ataccagatt ctacactgtt     5640

gttatttcat gagacgtgaa tgttgcagag agtgggggga ttctggttgt taaggaactt     5700

acactgggga gctttactct tccgtgtcaa caatgtgact acatgttctc cagattagcc     5760

acacatgcaa acatcagtgt ccttctagct ttagccgaga aagaaaccag tcccagggaa     5820

tgaatggtgg tctccccact cccggcagca ctttaggcag cccataagct atgcgagaat     5880

gtgaacgctc accttgctcc gtcacggttc tgacctacca cataaacagg aagaagccag     5940

tgaccggaac agctctagga ataacaagtc agaatagaag tgtcctttat attaccagaa     6000

aatatgggct tggcctaagt cgctgtctcc taacctgccg gggtcattcc ccaccaaaca     6060

ccccatacta aggagccatg agccacctgg acattcacct tttctttgac catctggagt     6120

ctggggcaac ttaaggaggc accacacagt ggtgcaggca catttccaag cgtaggtgtc     6180

cctggctttt gtggccaaag ctagtgttat ggtcaacaac aggccagggt ctgtggggca     6240

ctgaccttga aagtggcaaa atggaggttt cacaggctgt gcgggagcag gacggcttgc     6300

ttcatctaac aatctcagtt tcctttaaaa aaagaaagaa aggaaaagat ttcataagca     6360

ggtgtcagtg gacagtttaa gtacttaacc atttctcttt cttcttatgg atgtgaactg     6420

tgctgtggat aaatcatttg tatttcttga atgttctcta tgactaacag ttattaagtc     6480

ggttgtgtat atgtgtaact aatgtaactg ccttttaaaa tttcattaca ataaaaatga     6540

ctttgctctg aacaacaaaa aaaaaaaaaa aaaaaa                               6576


<210>  158
<211>  717
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Ala Thr Pro Ala Ala Val Asn Pro Pro Glu Met Ala Ser Asp Ile 
1               5                   10                  15      


Pro Gly Ser Val Thr Leu Pro Val Ala Pro Met Ala Ala Thr Gly Gln 
            20                  25                  30          


Val Arg Met Ala Gly Ala Met Pro Ala Arg Gly Gly Lys Arg Arg Ser 
        35                  40                  45              


Gly Met Asp Phe Asp Asp Glu Asp Gly Glu Gly Pro Ser Lys Phe Ser 
    50                  55                  60                  


Arg Glu Asn His Ser Glu Ile Glu Arg Arg Arg Arg Asn Lys Met Thr 
65                  70                  75                  80  


Gln Tyr Ile Thr Glu Leu Ser Asp Met Val Pro Thr Cys Ser Ala Leu 
                85                  90                  95      


Ala Arg Lys Pro Asp Lys Leu Thr Ile Leu Arg Met Ala Val Ser His 
            100                 105                 110         


Met Lys Ser Met Arg Gly Thr Gly Asn Lys Ser Thr Asp Gly Ala Tyr 
        115                 120                 125             


Lys Pro Ser Phe Leu Thr Glu Gln Glu Leu Lys His Leu Ile Leu Glu 
    130                 135                 140                 


Ala Ala Asp Gly Phe Leu Phe Val Val Ala Ala Glu Thr Gly Arg Val 
145                 150                 155                 160 


Ile Tyr Val Ser Asp Ser Val Thr Pro Val Leu Asn Gln Pro Gln Ser 
                165                 170                 175     


Glu Trp Phe Gly Ser Thr Leu Tyr Glu Gln Val His Pro Asp Asp Val 
            180                 185                 190         


Glu Lys Leu Arg Glu Gln Leu Cys Thr Ser Glu Asn Ser Met Thr Gly 
        195                 200                 205             


Arg Ile Leu Asp Leu Lys Thr Gly Thr Val Lys Lys Glu Gly Gln Gln 
    210                 215                 220                 


Ser Ser Met Arg Met Cys Met Gly Ser Arg Arg Ser Phe Ile Cys Arg 
225                 230                 235                 240 


Met Arg Cys Gly Asn Ala Pro Leu Asp His Leu Pro Leu Asn Arg Ile 
                245                 250                 255     


Thr Thr Met Arg Lys Arg Phe Arg Asn Gly Leu Gly Pro Val Lys Glu 
            260                 265                 270         


Gly Glu Ala Gln Tyr Ala Val Val His Cys Thr Gly Tyr Ile Lys Ala 
        275                 280                 285             


Trp Pro Pro Ala Gly Met Thr Ile Pro Glu Glu Asp Ala Asp Val Gly 
    290                 295                 300                 


Gln Gly Ser Lys Tyr Cys Leu Val Ala Ile Gly Arg Leu Gln Val Thr 
305                 310                 315                 320 


Ser Ser Pro Val Cys Met Asp Met Asn Gly Met Ser Val Pro Thr Glu 
                325                 330                 335     


Phe Leu Ser Arg His Asn Ser Asp Gly Ile Ile Thr Phe Val Asp Pro 
            340                 345                 350         


Arg Cys Ile Ser Val Ile Gly Tyr Gln Pro Gln Asp Leu Leu Gly Lys 
        355                 360                 365             


Asp Ile Leu Glu Phe Cys His Pro Glu Asp Gln Ser His Leu Arg Glu 
    370                 375                 380                 


Ser Phe Gln Gln Val Val Lys Leu Lys Gly Gln Val Leu Ser Val Met 
385                 390                 395                 400 


Tyr Arg Phe Arg Thr Lys Asn Arg Glu Trp Met Leu Ile Arg Thr Ser 
                405                 410                 415     


Ser Phe Thr Phe Gln Asn Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile 
            420                 425                 430         


Cys Thr Asn Thr Asn Val Lys Gln Leu Gln Gln Gln Gln Ala Glu Leu 
        435                 440                 445             


Glu Val His Gln Arg Asp Gly Leu Ser Ser Tyr Asp Leu Ser Gln Val 
    450                 455                 460                 


Pro Val Pro Asn Leu Pro Ala Gly Val His Glu Ala Gly Lys Ser Val 
465                 470                 475                 480 


Glu Lys Ala Asp Ala Ile Phe Ser Gln Glu Arg Asp Pro Arg Phe Ala 
                485                 490                 495     


Glu Met Phe Ala Gly Ile Ser Ala Ser Glu Lys Lys Met Met Ser Ser 
            500                 505                 510         


Ala Ser Ala Ala Gly Thr Gln Gln Ile Tyr Ser Gln Gly Ser Pro Phe 
        515                 520                 525             


Pro Ser Gly His Ser Gly Lys Ala Phe Ser Ser Ser Val Val His Val 
    530                 535                 540                 


Pro Gly Val Asn Asp Ile Gln Ser Ser Ser Ser Thr Gly Gln Asn Met 
545                 550                 555                 560 


Ser Gln Ile Ser Arg Gln Leu Asn Gln Ser Gln Val Ala Trp Thr Gly 
                565                 570                 575     


Ser Arg Pro Pro Phe Pro Gly Gln Gln Ile Pro Ser Gln Ser Ser Lys 
            580                 585                 590         


Thr Gln Ser Ser Pro Phe Gly Ile Gly Thr Ser His Thr Tyr Pro Ala 
        595                 600                 605             


Asp Pro Ser Ser Tyr Ser Pro Leu Ser Ser Pro Ala Thr Ser Ser Pro 
    610                 615                 620                 


Ser Gly Asn Ala Tyr Ser Ser Leu Ala Asn Arg Thr Pro Gly Phe Ala 
625                 630                 635                 640 


Glu Ser Gly Gln Ser Ser Gly Gln Phe Gln Gly Arg Pro Ser Glu Val 
                645                 650                 655     


Trp Ser Gln Trp Gln Ser Gln His His Gly Gln Gln Ser Gly Glu Gln 
            660                 665                 670         


His Ser His Gln Gln Pro Gly Gln Thr Glu Val Phe Gln Asp Met Leu 
        675                 680                 685             


Pro Met Pro Gly Asp Pro Thr Gln Gly Thr Gly Asn Tyr Asn Ile Glu 
    690                 695                 700                 


Asp Phe Ala Asp Leu Gly Met Phe Pro Pro Phe Ser Glu 
705                 710                 715         


<210>  159
<211>  1834
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (239)..(1645)

<400>  159
aaacagcaag cagggctctg gcagctgctg cagacggctt cacacaggga cgcgggctgc       60

catcttgctc taagtgaaag tgaaagaaaa gtcggcagca gagggaacag ggaagaaacc      120

taaaggctgc aggctgccag gtgtgcttgg agagccccct tcttccgccg ggcctcgcaa      180

gcagcgtagg actgtggaga agggcggtgg gcaaggaggg aactcgagag cagcctcc        238

atg ggc aca cag gag ggc tgg tgc ctg ctg ctc tgc ctg gct cta tct        286
Met Gly Thr Gln Glu Gly Trp Cys Leu Leu Leu Cys Leu Ala Leu Ser           
1               5                   10                  15                

gga gca gca gaa acc aag ccc cac cca gca gag ggg cag tgg cgg gca        334
Gly Ala Ala Glu Thr Lys Pro His Pro Ala Glu Gly Gln Trp Arg Ala           
            20                  25                  30                    

gtg gac gtg gtc cta gac tgc ttc ctg gcg aag gac ggt gcg cac cgt        382
Val Asp Val Val Leu Asp Cys Phe Leu Ala Lys Asp Gly Ala His Arg           
        35                  40                  45                        

gga gct ctc gcc agc agt gag gac agg gca agg gcc tcc ctt gtg ctg        430
Gly Ala Leu Ala Ser Ser Glu Asp Arg Ala Arg Ala Ser Leu Val Leu           
    50                  55                  60                            

aag cag gtg cca gtg ctg gac gat ggc tcc ctg gag gac ttc acc gat        478
Lys Gln Val Pro Val Leu Asp Asp Gly Ser Leu Glu Asp Phe Thr Asp           
65                  70                  75                  80            

ttc caa ggg ggc aca ctg gcc caa gat gac cca cct att atc ttt gag        526
Phe Gln Gly Gly Thr Leu Ala Gln Asp Asp Pro Pro Ile Ile Phe Glu           
                85                  90                  95                

gcc tca gtg gac ctg gtc cag att ccc cag gcc gag gcc ttg ctc cat        574
Ala Ser Val Asp Leu Val Gln Ile Pro Gln Ala Glu Ala Leu Leu His           
            100                 105                 110                   

gct gac tgc agt ggg aag gag gtg acc tgt gag atc tcc cgc tac ttt        622
Ala Asp Cys Ser Gly Lys Glu Val Thr Cys Glu Ile Ser Arg Tyr Phe           
        115                 120                 125                       

ctc cag atg aca gag acc act gtt aag aca gca gct tgg ttc atg gcc        670
Leu Gln Met Thr Glu Thr Thr Val Lys Thr Ala Ala Trp Phe Met Ala           
    130                 135                 140                           

aac atg cag gtc tct gga ggg gga cct agc atc tcc ttg gtg atg aag        718
Asn Met Gln Val Ser Gly Gly Gly Pro Ser Ile Ser Leu Val Met Lys           
145                 150                 155                 160           

act ccc agg gtc acc aag aat gag gcg ctc tgg cac ccg acg ctg aac        766
Thr Pro Arg Val Thr Lys Asn Glu Ala Leu Trp His Pro Thr Leu Asn           
                165                 170                 175               

ttg cca ctg agc ccc cag ggg act gtg cga act gca gtg gag ttc cag        814
Leu Pro Leu Ser Pro Gln Gly Thr Val Arg Thr Ala Val Glu Phe Gln           
            180                 185                 190                   

gtg atg aca cag acc caa tcc ctg agc ttc ctg ctg ggg tcc tca gcc        862
Val Met Thr Gln Thr Gln Ser Leu Ser Phe Leu Leu Gly Ser Ser Ala           
        195                 200                 205                       

tcc ttg gac tgt ggc ttc tcc atg gca ccg ggc ttg gac ctc atc agt        910
Ser Leu Asp Cys Gly Phe Ser Met Ala Pro Gly Leu Asp Leu Ile Ser           
    210                 215                 220                           

gtg gag tgg cga ctg cag cac aag ggc agg ggt cag ttg gtg tac agc        958
Val Glu Trp Arg Leu Gln His Lys Gly Arg Gly Gln Leu Val Tyr Ser           
225                 230                 235                 240           

tgg acc gca ggg cag ggg cag gct gtg cgg aag ggc gct acc ctg gag       1006
Trp Thr Ala Gly Gln Gly Gln Ala Val Arg Lys Gly Ala Thr Leu Glu           
                245                 250                 255               

cct gca caa ctg ggc atg gcc agg gat gcc tcc ctc acc ctg ccc ggc       1054
Pro Ala Gln Leu Gly Met Ala Arg Asp Ala Ser Leu Thr Leu Pro Gly           
            260                 265                 270                   

ctc act ata cag gac gag ggg acc tac att tgc cag atc acc acc tct       1102
Leu Thr Ile Gln Asp Glu Gly Thr Tyr Ile Cys Gln Ile Thr Thr Ser           
        275                 280                 285                       

ctg tac cga gct cag cag atc atc cag ctc aac atc caa gct tcc cct       1150
Leu Tyr Arg Ala Gln Gln Ile Ile Gln Leu Asn Ile Gln Ala Ser Pro           
    290                 295                 300                           

aaa gta cga ctg agc ttg gca aac gaa gct ctg ctg ccc acc ctc atc       1198
Lys Val Arg Leu Ser Leu Ala Asn Glu Ala Leu Leu Pro Thr Leu Ile           
305                 310                 315                 320           

tgc gac att gct ggc tat tac cct ctg gat gtg gtg gtg acg tgg acc       1246
Cys Asp Ile Ala Gly Tyr Tyr Pro Leu Asp Val Val Val Thr Trp Thr           
                325                 330                 335               

cga gag gag ctg ggt gga tcc cca gcc caa gtc tct ggt gcc tcc ttc       1294
Arg Glu Glu Leu Gly Gly Ser Pro Ala Gln Val Ser Gly Ala Ser Phe           
            340                 345                 350                   

tcc agc ctc agg caa agc gtg gca ggc acc tac agc atc tcc tcc tct       1342
Ser Ser Leu Arg Gln Ser Val Ala Gly Thr Tyr Ser Ile Ser Ser Ser           
        355                 360                 365                       

ctc acc gca gaa cct ggc tct gca ggt gcc act tac acc tgc cag gtc       1390
Leu Thr Ala Glu Pro Gly Ser Ala Gly Ala Thr Tyr Thr Cys Gln Val           
    370                 375                 380                           

aca cac atc tct ctg gag gag ccc ctt ggg gcc agc acc cag gtt gtc       1438
Thr His Ile Ser Leu Glu Glu Pro Leu Gly Ala Ser Thr Gln Val Val           
385                 390                 395                 400           

cca cca gag cgg aga aca gcc ttg gga gtc atc ttt gcc agc agt ctc       1486
Pro Pro Glu Arg Arg Thr Ala Leu Gly Val Ile Phe Ala Ser Ser Leu           
                405                 410                 415               

ttc ctt ctt gca ctg atg ttc ctg ggg ctt cag aga cgg caa gca cct       1534
Phe Leu Leu Ala Leu Met Phe Leu Gly Leu Gln Arg Arg Gln Ala Pro           
            420                 425                 430                   

aca gga ctt ggg ctg ctt cag gct gaa cgc tgg gag acc act tcc tgt       1582
Thr Gly Leu Gly Leu Leu Gln Ala Glu Arg Trp Glu Thr Thr Ser Cys           
        435                 440                 445                       

gct gac aca cag agc tcc cat ctc cat gaa gac cgc aca gcg cgt gta       1630
Ala Asp Thr Gln Ser Ser His Leu His Glu Asp Arg Thr Ala Arg Val           
    450                 455                 460                           

agc cag ccc agc tga cctaaagcga catgagacta ctagaaagaa acgacaccct       1685
Ser Gln Pro Ser                                                           
465                                                                       

tccccaagcc cccacagcta ctccaaccca aacaacaacc aagccagttt aatggtagga     1745

atttgtattt tttgcctttg ttcagaatac atgacattgg taaatatgcc acatgccttt     1805

ggtggaagta caaaaaaaaa aaaaaaaaa                                       1834


<210>  160
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Gly Thr Gln Glu Gly Trp Cys Leu Leu Leu Cys Leu Ala Leu Ser 
1               5                   10                  15      


Gly Ala Ala Glu Thr Lys Pro His Pro Ala Glu Gly Gln Trp Arg Ala 
            20                  25                  30          


Val Asp Val Val Leu Asp Cys Phe Leu Ala Lys Asp Gly Ala His Arg 
        35                  40                  45              


Gly Ala Leu Ala Ser Ser Glu Asp Arg Ala Arg Ala Ser Leu Val Leu 
    50                  55                  60                  


Lys Gln Val Pro Val Leu Asp Asp Gly Ser Leu Glu Asp Phe Thr Asp 
65                  70                  75                  80  


Phe Gln Gly Gly Thr Leu Ala Gln Asp Asp Pro Pro Ile Ile Phe Glu 
                85                  90                  95      


Ala Ser Val Asp Leu Val Gln Ile Pro Gln Ala Glu Ala Leu Leu His 
            100                 105                 110         


Ala Asp Cys Ser Gly Lys Glu Val Thr Cys Glu Ile Ser Arg Tyr Phe 
        115                 120                 125             


Leu Gln Met Thr Glu Thr Thr Val Lys Thr Ala Ala Trp Phe Met Ala 
    130                 135                 140                 


Asn Met Gln Val Ser Gly Gly Gly Pro Ser Ile Ser Leu Val Met Lys 
145                 150                 155                 160 


Thr Pro Arg Val Thr Lys Asn Glu Ala Leu Trp His Pro Thr Leu Asn 
                165                 170                 175     


Leu Pro Leu Ser Pro Gln Gly Thr Val Arg Thr Ala Val Glu Phe Gln 
            180                 185                 190         


Val Met Thr Gln Thr Gln Ser Leu Ser Phe Leu Leu Gly Ser Ser Ala 
        195                 200                 205             


Ser Leu Asp Cys Gly Phe Ser Met Ala Pro Gly Leu Asp Leu Ile Ser 
    210                 215                 220                 


Val Glu Trp Arg Leu Gln His Lys Gly Arg Gly Gln Leu Val Tyr Ser 
225                 230                 235                 240 


Trp Thr Ala Gly Gln Gly Gln Ala Val Arg Lys Gly Ala Thr Leu Glu 
                245                 250                 255     


Pro Ala Gln Leu Gly Met Ala Arg Asp Ala Ser Leu Thr Leu Pro Gly 
            260                 265                 270         


Leu Thr Ile Gln Asp Glu Gly Thr Tyr Ile Cys Gln Ile Thr Thr Ser 
        275                 280                 285             


Leu Tyr Arg Ala Gln Gln Ile Ile Gln Leu Asn Ile Gln Ala Ser Pro 
    290                 295                 300                 


Lys Val Arg Leu Ser Leu Ala Asn Glu Ala Leu Leu Pro Thr Leu Ile 
305                 310                 315                 320 


Cys Asp Ile Ala Gly Tyr Tyr Pro Leu Asp Val Val Val Thr Trp Thr 
                325                 330                 335     


Arg Glu Glu Leu Gly Gly Ser Pro Ala Gln Val Ser Gly Ala Ser Phe 
            340                 345                 350         


Ser Ser Leu Arg Gln Ser Val Ala Gly Thr Tyr Ser Ile Ser Ser Ser 
        355                 360                 365             


Leu Thr Ala Glu Pro Gly Ser Ala Gly Ala Thr Tyr Thr Cys Gln Val 
    370                 375                 380                 


Thr His Ile Ser Leu Glu Glu Pro Leu Gly Ala Ser Thr Gln Val Val 
385                 390                 395                 400 


Pro Pro Glu Arg Arg Thr Ala Leu Gly Val Ile Phe Ala Ser Ser Leu 
                405                 410                 415     


Phe Leu Leu Ala Leu Met Phe Leu Gly Leu Gln Arg Arg Gln Ala Pro 
            420                 425                 430         


Thr Gly Leu Gly Leu Leu Gln Ala Glu Arg Trp Glu Thr Thr Ser Cys 
        435                 440                 445             


Ala Asp Thr Gln Ser Ser His Leu His Glu Asp Arg Thr Ala Arg Val 
    450                 455                 460                 


Ser Gln Pro Ser 
465             


<210>  161
<211>  6734
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (113)..(2854)

<400>  161
atgctcagac ggcggccagg tcgcgccgcg agcgagcttc cgcgccgccc gcacgcgcga       60

cctacctggg cgctccgcgc ccccggatgc tgcaggttat tcagcgatag tt atg acc      118
                                                          Met Thr         
                                                          1               

tcc cgg tta cgt gcg ttg ggt gga aga att aat aat ata cgc acc tcg        166
Ser Arg Leu Arg Ala Leu Gly Gly Arg Ile Asn Asn Ile Arg Thr Ser           
        5                   10                  15                        

gag tta ccc aaa gag aaa act cga tca gaa gtc att tgc agc atc cac        214
Glu Leu Pro Lys Glu Lys Thr Arg Ser Glu Val Ile Cys Ser Ile His           
    20                  25                  30                            

ttt tta gat ggc gtg gta cag acc ttt aaa gtt act aaa caa gac act        262
Phe Leu Asp Gly Val Val Gln Thr Phe Lys Val Thr Lys Gln Asp Thr           
35                  40                  45                  50            

ggc cag gtt ctt ctg gat atg gtg cac aac cac ctg ggt gtg act gaa        310
Gly Gln Val Leu Leu Asp Met Val His Asn His Leu Gly Val Thr Glu           
                55                  60                  65                

aag gaa tat ttt ggt tta cag cat gat gac gac tcc gtg gac tct cct        358
Lys Glu Tyr Phe Gly Leu Gln His Asp Asp Asp Ser Val Asp Ser Pro           
            70                  75                  80                    

aga tgg ctg gaa gca agc aaa gcc atc agg aag cag tta aaa gga ggt        406
Arg Trp Leu Glu Ala Ser Lys Ala Ile Arg Lys Gln Leu Lys Gly Gly           
        85                  90                  95                        

ttc ccc tgt acc ctg cat ttt cga gta aga ttt ttt ata cct gat ccc        454
Phe Pro Cys Thr Leu His Phe Arg Val Arg Phe Phe Ile Pro Asp Pro           
    100                 105                 110                           

aac aca ctg cag caa gaa caa acc agg cac ttg tat ttc tta caa ctg        502
Asn Thr Leu Gln Gln Glu Gln Thr Arg His Leu Tyr Phe Leu Gln Leu           
115                 120                 125                 130           

aag atg gat att tgc gaa gga agg tta acc tgc cct ctt aac tca gca        550
Lys Met Asp Ile Cys Glu Gly Arg Leu Thr Cys Pro Leu Asn Ser Ala           
                135                 140                 145               

gtg gtt cta gcg tcc tat gcc gta caa tct cat ttt gga gac tat aat        598
Val Val Leu Ala Ser Tyr Ala Val Gln Ser His Phe Gly Asp Tyr Asn           
            150                 155                 160                   

tct tcc ata cat cat cca ggc tat ctt tcc gat agt cac ttt ata ccc        646
Ser Ser Ile His His Pro Gly Tyr Leu Ser Asp Ser His Phe Ile Pro           
        165                 170                 175                       

gat caa aat gag gac ttt tta aca aaa gtc gaa tct ctg cat gag cag        694
Asp Gln Asn Glu Asp Phe Leu Thr Lys Val Glu Ser Leu His Glu Gln           
    180                 185                 190                           

cac agt ggg cta aaa caa tca gaa gca gaa tcc tgc tat atc aac ata        742
His Ser Gly Leu Lys Gln Ser Glu Ala Glu Ser Cys Tyr Ile Asn Ile           
195                 200                 205                 210           

gcg cgg acc ctc gac ttc tat gga gta gaa ctg cac agt ggt agg gat        790
Ala Arg Thr Leu Asp Phe Tyr Gly Val Glu Leu His Ser Gly Arg Asp           
                215                 220                 225               

ctg cac aat tta gac cta atg att gga att gct tcc gcg ggt gtt gct        838
Leu His Asn Leu Asp Leu Met Ile Gly Ile Ala Ser Ala Gly Val Ala           
            230                 235                 240                   

gtg tac cga aaa tac att tgc aca agt ttc tat cct tgg gtg aac att        886
Val Tyr Arg Lys Tyr Ile Cys Thr Ser Phe Tyr Pro Trp Val Asn Ile           
        245                 250                 255                       

ctc aaa att tct ttc aaa agg aaa aag ttc ttc ata cat cag cga cag        934
Leu Lys Ile Ser Phe Lys Arg Lys Lys Phe Phe Ile His Gln Arg Gln           
    260                 265                 270                           

aaa cag gct gaa tcc agg gaa cat att gtg gcc ttc aac atg ctg aat        982
Lys Gln Ala Glu Ser Arg Glu His Ile Val Ala Phe Asn Met Leu Asn           
275                 280                 285                 290           

tac cga tct tgc aaa aac ttg tgg aaa tcc tgt gtt gag cac cat acg       1030
Tyr Arg Ser Cys Lys Asn Leu Trp Lys Ser Cys Val Glu His His Thr           
                295                 300                 305               

ttc ttt cag gca aag aag cta cta cct cag gaa aag aat gtt ctg tct       1078
Phe Phe Gln Ala Lys Lys Leu Leu Pro Gln Glu Lys Asn Val Leu Ser           
            310                 315                 320                   

cag tac tgg act atg ggc tct cgg aac acc aaa aag tcg gta aat aac       1126
Gln Tyr Trp Thr Met Gly Ser Arg Asn Thr Lys Lys Ser Val Asn Asn           
        325                 330                 335                       

caa tat tgc aaa aag gtg att ggc ggg atg gtg tgg aac cca gcc atg       1174
Gln Tyr Cys Lys Lys Val Ile Gly Gly Met Val Trp Asn Pro Ala Met           
    340                 345                 350                           

cgg aga tcc tta tca gtg gag cac tta gaa acc aag agt ctg cct tct       1222
Arg Arg Ser Leu Ser Val Glu His Leu Glu Thr Lys Ser Leu Pro Ser           
355                 360                 365                 370           

cgt tcc cct ccc att act ccc aac tgg cga agt cct cgg ctc cgg cac       1270
Arg Ser Pro Pro Ile Thr Pro Asn Trp Arg Ser Pro Arg Leu Arg His           
                375                 380                 385               

gaa atc cga aag cca cgc cac tct tct gca gat aac ctt gca aat gaa       1318
Glu Ile Arg Lys Pro Arg His Ser Ser Ala Asp Asn Leu Ala Asn Glu           
            390                 395                 400                   

atg acc tac atc acg gaa acg gaa gat gta ttt tac acg tac aag ggc       1366
Met Thr Tyr Ile Thr Glu Thr Glu Asp Val Phe Tyr Thr Tyr Lys Gly           
        405                 410                 415                       

tct ctg gcc cct caa gac agc gat tct gaa gtt tct cag aac cga agc       1414
Ser Leu Ala Pro Gln Asp Ser Asp Ser Glu Val Ser Gln Asn Arg Ser           
    420                 425                 430                           

ccg cac caa gag agt tta tcc gag aac aat ccg gca caa agc tac ctg       1462
Pro His Gln Glu Ser Leu Ser Glu Asn Asn Pro Ala Gln Ser Tyr Leu           
435                 440                 445                 450           

acc cag aag tca tcc agt tct gtg tct cca tct tca aat gct cca ggc       1510
Thr Gln Lys Ser Ser Ser Ser Val Ser Pro Ser Ser Asn Ala Pro Gly           
                455                 460                 465               

tcc tgc tca cct gac ggc gtt gat cag cag ctc tta gat gac ttc cac       1558
Ser Cys Ser Pro Asp Gly Val Asp Gln Gln Leu Leu Asp Asp Phe His           
            470                 475                 480                   

agg gtg acc aaa ggg ggc tcc acc gag gac gcc agc cag tac tac tgt       1606
Arg Val Thr Lys Gly Gly Ser Thr Glu Asp Ala Ser Gln Tyr Tyr Cys           
        485                 490                 495                       

gac aag aat gat aat ggt gac agc tac tta gtc ttg atc cgt atc aca       1654
Asp Lys Asn Asp Asn Gly Asp Ser Tyr Leu Val Leu Ile Arg Ile Thr           
    500                 505                 510                           

cca gat gaa gat gga aaa ttt gga ttt aat ctt aag gga gga gtg gat       1702
Pro Asp Glu Asp Gly Lys Phe Gly Phe Asn Leu Lys Gly Gly Val Asp           
515                 520                 525                 530           

caa aag atg cct ctt gtg gta tca agg ata aac cca gag tca cct gcg       1750
Gln Lys Met Pro Leu Val Val Ser Arg Ile Asn Pro Glu Ser Pro Ala           
                535                 540                 545               

gac acc tgc att cct aag ctg aac gaa ggg gat caa atc gtg tta atc       1798
Asp Thr Cys Ile Pro Lys Leu Asn Glu Gly Asp Gln Ile Val Leu Ile           
            550                 555                 560                   

aat ggc cgg gac atc tca gaa cac acg cat gac caa gtg gtg atg ttc       1846
Asn Gly Arg Asp Ile Ser Glu His Thr His Asp Gln Val Val Met Phe           
        565                 570                 575                       

atc aaa gcc agc cgg gag tcc cac tca cgg gag ctg gcc ctg gtg atc       1894
Ile Lys Ala Ser Arg Glu Ser His Ser Arg Glu Leu Ala Leu Val Ile           
    580                 585                 590                           

agg agg aga gct gtc cgc tca ttt gct gac ttc aag tct gaa gat gaa       1942
Arg Arg Arg Ala Val Arg Ser Phe Ala Asp Phe Lys Ser Glu Asp Glu           
595                 600                 605                 610           

ctg aac cag ctt ttc ccc gaa gcc att ttc ccc atg tgt ccg gag ggt       1990
Leu Asn Gln Leu Phe Pro Glu Ala Ile Phe Pro Met Cys Pro Glu Gly           
                615                 620                 625               

ggg gac act ttg gag gga tcc atg gca cag cta aag aag ggc ctc gaa       2038
Gly Asp Thr Leu Glu Gly Ser Met Ala Gln Leu Lys Lys Gly Leu Glu           
            630                 635                 640                   

agc ggg acg gtg ctg atc cag ttt gag caa ctc tac aga aaa aag cca       2086
Ser Gly Thr Val Leu Ile Gln Phe Glu Gln Leu Tyr Arg Lys Lys Pro           
        645                 650                 655                       

ggt ttg gcc atc acg ttt gca aag ctg cct caa aat ttg gac aaa aac       2134
Gly Leu Ala Ile Thr Phe Ala Lys Leu Pro Gln Asn Leu Asp Lys Asn           
    660                 665                 670                           

cga tat aaa gat gtg ctg cct tat gac acc acc cgg gta tta ttg cag       2182
Arg Tyr Lys Asp Val Leu Pro Tyr Asp Thr Thr Arg Val Leu Leu Gln           
675                 680                 685                 690           

gga aat gaa gat tat att aat gca agt tac gtg aac atg gaa att cct       2230
Gly Asn Glu Asp Tyr Ile Asn Ala Ser Tyr Val Asn Met Glu Ile Pro           
                695                 700                 705               

gct gct aac ctt gtg aac aag tac atc gcc act cag ggg ccc ctg ccg       2278
Ala Ala Asn Leu Val Asn Lys Tyr Ile Ala Thr Gln Gly Pro Leu Pro           
            710                 715                 720                   

cat acc tgt gca cag ttt tgg cag gtt gtc tgg gat cag aag ttg tca       2326
His Thr Cys Ala Gln Phe Trp Gln Val Val Trp Asp Gln Lys Leu Ser           
        725                 730                 735                       

ctc att gtc atg ttg acg act ctc aca gaa cga ggg cgg acc aaa tgt       2374
Leu Ile Val Met Leu Thr Thr Leu Thr Glu Arg Gly Arg Thr Lys Cys           
    740                 745                 750                           

cac cag tac tgg cca gat ccc ccc gac gtc atg aac cac ggc ggc ttt       2422
His Gln Tyr Trp Pro Asp Pro Pro Asp Val Met Asn His Gly Gly Phe           
755                 760                 765                 770           

cac atc cag tgt cag tca gag gac tgc acc atc gcc tat gtg tcc cga       2470
His Ile Gln Cys Gln Ser Glu Asp Cys Thr Ile Ala Tyr Val Ser Arg           
                775                 780                 785               

gaa atg ctg gtc aca aac acc cag acc ggg gaa gaa cac aca gtg aca       2518
Glu Met Leu Val Thr Asn Thr Gln Thr Gly Glu Glu His Thr Val Thr           
            790                 795                 800                   

cat ctc cag tac gtc gca tgg cct gac cac ggt gtg ccc gat gac tcc       2566
His Leu Gln Tyr Val Ala Trp Pro Asp His Gly Val Pro Asp Asp Ser           
        805                 810                 815                       

tcc gac ttt ctg gaa ttt gta aac tat gtg agg tct ctg aga gtg gac       2614
Ser Asp Phe Leu Glu Phe Val Asn Tyr Val Arg Ser Leu Arg Val Asp           
    820                 825                 830                           

agc gag ccc gtc cta gtt cac tgc agt gct gga ata ggt cga acc ggt       2662
Ser Glu Pro Val Leu Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly           
835                 840                 845                 850           

gtg ttg gtc act atg gaa aca gcc atg tgc cta act gag agg aac ctg       2710
Val Leu Val Thr Met Glu Thr Ala Met Cys Leu Thr Glu Arg Asn Leu           
                855                 860                 865               

ccc att tac cca ctg gat att gtc cga aaa atg cga gac cag cgc gcc       2758
Pro Ile Tyr Pro Leu Asp Ile Val Arg Lys Met Arg Asp Gln Arg Ala           
            870                 875                 880                   

atg atg gtg cag aca tca agc cag tac aag ttt gtg tgt gaa gcg att       2806
Met Met Val Gln Thr Ser Ser Gln Tyr Lys Phe Val Cys Glu Ala Ile           
        885                 890                 895                       

ctt cgt gtg tat gaa gaa ggt tta gtc caa atg ctg gat cct agt taa       2854
Leu Arg Val Tyr Glu Glu Gly Leu Val Gln Met Leu Asp Pro Ser               
    900                 905                 910                           

gacaactgtg aaaaagttca ttcctctttc ccaagggcat cctccttgaa agaggaggac     2914

agacctctct ggaagcagca agaggaacca gtagctgtgg gaaaggaatg ggcacctctg     2974

aacccaggca ctttaaactt ctatagaaaa gatatcgtgt acataggaac tggtgtagat     3034

aagcatgcaa ttatggcatc atttaggcct gtatttctat ggaaagatac aaaaaggatc     3094

tcagtttggg gcctgtccta atgccttctt ccctaacatc accacacaca cccctgtcgg     3154

catcctggag caattgagac cggacaccca cagagctgtt gtcctcccag caacaagatg     3214

gtgtggttat cttgggtcat ttggatgttt tgtttgtttc tgtgtgtcag actgtaaggg     3274

ctgagctttc tgtgcttcta ggtggagctg gaacaattca gattcacccg ccctgatgct     3334

aaggaaaccc tgacgtatgt actagatggc agggcactgg gggtcaggct gaaggctgag     3394

caacacctct ctgccctccc tccctttgtc ccatctccca gcgacttcca atattcatgt     3454

ttctgagaat tgtgtccctc ttcaggttcc ctcttggtgc ctaacctgga ttagtaatgt     3514

gcattcaggt gaattttcag ctgaggctct gagaactggt actctcagtg tgttctggtc     3574

atcttgtggc ttagttgtag aagcaggtgt gtctcttgcc tctgcttgcc tcctactgca     3634

cactcagcac ccaggactgg aatcaccgac tactgaatct cctacatgta ttgctgctac     3694

ttcaagctcc tccacttgaa accttatgat tttcccaagg ggagatggga cagtgtcatc     3754

taaatattcc gaatgtttgg ccttctgaga aaagagcttc tagtaattga accatgggaa     3814

acccagcttc tggagggttg gccgtggggc tgtgtacatg tgtgtgccca ggggtgagtg     3874

tttctcagga ttcctaacga ttcaaattac cgttgagtat atataaagaa tgagtctctg     3934

tatggaagaa caaatgtgtg cattcacccc cagtcacaat ggtctccatt gcatttcaaa     3994

ggagaggatc agactatctg aatataaaca caatctgatg ttaatttatt ctaagaacac     4054

catcattttg attgtcctaa agaattctgc ctttgtgaat accgtgttaa atttttttaa     4114

atttgtgaca ggattgtagc aaattattat ttaaggaaaa taaattgtgt aaacatttaa     4174

tgtggtattt ttgaacagcg gtttttatgt actcagaaga ggaagtaaag ccaggttctt     4234

aatggtattt atagaaaaga tgttttcata ttataatgca cataaatgaa gccattttga     4294

tattcagcaa attcggtgcc aattgaatag tttgctggta gcaagacgga tgaagaccta     4354

tatgggagat tctttatctc tagagctagc atatttactt gcatactttg tttcttttcc     4414

acatggatat tttactgcta aatggcagag gtgggaggga gatgtcacac agtaccataa     4474

ccccatattg aaaacaagaa accaccagaa agtttgcagc taaggggcag gggattcagt     4534

tcctacgccc actcagcact aactacttgc gggcctggtt gcttagaagc tctacctctc     4594

tttcattatc tgtaaaatag aaacaatact taggacttta gttggaacat gaggattgaa     4654

taagatcacg ctattcatgt gactttttat cggctagaac agcaacagac actgctgtgg     4714

gtgagttact tagaaaagtt tagttatcag tgattagccc aaaaacacat cagtcaaaaa     4774

tagaatccac tggatttttg tctctctttt tagagacagg gtctcactgt cgcccaggct     4834

ggagtacagt ggcatgatca ttgttcactg cagcctcaaa ttcctgggct caagcaatcc     4894

tcgcacctca gcctcctgag tagccgggac tataggcaca tgccacctca cctggcttgt     4954

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     5014

agagacagga tcttgatgtg ttgcctaggc tggtctcaaa ctcctggcct caagtgatct     5074

tcccacctca gcctccaaaa ctgttgggat tataggcgtg agccactgtg cccagcctaa     5134

ctgggttttt atgagaggaa aatagaaaat gctcttctag aagagagaga acaagagcac     5194

aaaataatct ggactcacaa aaattcagca agctccaaga aagggggatg gagggaacgc     5254

tggcaaaaat ttaaatgcca ttaggatatt tagcaagtta ttactgtttg gtaaaaatgc     5314

atcatcaccc tgtgtgcaaa atgcttgcaa agtagtctaa atgtctttgg agatgggtgt     5374

tttactgctt ttttccaaaa acaaattgtt tattatggtt gcagaaatgc agccattacg     5434

gtcacataaa tttctaaaaa gcctaccaaa ggttgcaagc agtcttctgc cactgggcag     5494

gccagcagtt cagacccagc gaggttgcca ggaacaaatc caggaaatac tgggaagaac     5554

aagacaagag aattacctaa aagagcaaac aattcaagta aatcctgtag ctattaccac     5614

ttaaaatccg tagctcaaga ttcctgtttc accaccttat acacttaagc aattatactt     5674

aagccttttt ttagtcctaa gtgaagaact acatcagaat caggataagt attttgcctg     5734

ggaaatttgg ctgcatatga atggagaaga catttacatc ctatgttctg gcactttctg     5794

aaagatctaa ttaaacatgt tgatgtgcca atttaatcaa gatgagagat ccctgctggt     5854

gtcaccctct agaacctgca cttggtgttt tgactttcca gaagaaaaaa atgcaacttt     5914

ggttaggggg cagtggttgg atcacacagt tgtctttcgt ttcctaccac agtaattcat     5974

atttaaatat gcttttagat tagtgtggat actattgctg ctgtgttgct acctgacctt     6034

tttctggggg gggtacctca gaaatgagca tttgagggca agcgaaaaag ccctcttcat     6094

cctccagagg caacaaagag gcagcagaaa tggggaaaga ttgtgagagg cagggcttgg     6154

gtctagacct ggacttaggc aagatatgtt gccctcaacc ctgagttttc ttatatgtaa     6214

aaagggaagg ttgggctgga ctagatgagg tcaagatttg ccattctggg aggctgatat     6274

tccagagaat caaaattaat cctaaaccaa agctttatgg ctgctacaga gacatgtcac     6334

atttctgaga cttgtcacca agagtttgtc cctcagactt tggcgctgtt gaatgcaaag     6394

acaaggatgg ccaccttctg gttcttgcct gttgtcctca gctgagagca gtctcggtaa     6454

aggtggcaaa gattctgtga cctcagaccg gggaccaaat gcttgggagt ctgatggccg     6514

ggctgggcca ccattctcat agctctcatt ctgtttggag caaccaaagg atttgtgtga     6574

agttatttgg aaaaggacct taactgagca gtaatctttt ttctgtatat ttggaatgtt     6634

tttcattctg acctgttctg tcagtgattc tactgaaaaa caatttaatc aatataaaaa     6694

tgttcaagct atgcaacact gtaaaaaaaa aaaaaaaaaa                           6734


<210>  162
<211>  913
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Thr Ser Arg Leu Arg Ala Leu Gly Gly Arg Ile Asn Asn Ile Arg 
1               5                   10                  15      


Thr Ser Glu Leu Pro Lys Glu Lys Thr Arg Ser Glu Val Ile Cys Ser 
            20                  25                  30          


Ile His Phe Leu Asp Gly Val Val Gln Thr Phe Lys Val Thr Lys Gln 
        35                  40                  45              


Asp Thr Gly Gln Val Leu Leu Asp Met Val His Asn His Leu Gly Val 
    50                  55                  60                  


Thr Glu Lys Glu Tyr Phe Gly Leu Gln His Asp Asp Asp Ser Val Asp 
65                  70                  75                  80  


Ser Pro Arg Trp Leu Glu Ala Ser Lys Ala Ile Arg Lys Gln Leu Lys 
                85                  90                  95      


Gly Gly Phe Pro Cys Thr Leu His Phe Arg Val Arg Phe Phe Ile Pro 
            100                 105                 110         


Asp Pro Asn Thr Leu Gln Gln Glu Gln Thr Arg His Leu Tyr Phe Leu 
        115                 120                 125             


Gln Leu Lys Met Asp Ile Cys Glu Gly Arg Leu Thr Cys Pro Leu Asn 
    130                 135                 140                 


Ser Ala Val Val Leu Ala Ser Tyr Ala Val Gln Ser His Phe Gly Asp 
145                 150                 155                 160 


Tyr Asn Ser Ser Ile His His Pro Gly Tyr Leu Ser Asp Ser His Phe 
                165                 170                 175     


Ile Pro Asp Gln Asn Glu Asp Phe Leu Thr Lys Val Glu Ser Leu His 
            180                 185                 190         


Glu Gln His Ser Gly Leu Lys Gln Ser Glu Ala Glu Ser Cys Tyr Ile 
        195                 200                 205             


Asn Ile Ala Arg Thr Leu Asp Phe Tyr Gly Val Glu Leu His Ser Gly 
    210                 215                 220                 


Arg Asp Leu His Asn Leu Asp Leu Met Ile Gly Ile Ala Ser Ala Gly 
225                 230                 235                 240 


Val Ala Val Tyr Arg Lys Tyr Ile Cys Thr Ser Phe Tyr Pro Trp Val 
                245                 250                 255     


Asn Ile Leu Lys Ile Ser Phe Lys Arg Lys Lys Phe Phe Ile His Gln 
            260                 265                 270         


Arg Gln Lys Gln Ala Glu Ser Arg Glu His Ile Val Ala Phe Asn Met 
        275                 280                 285             


Leu Asn Tyr Arg Ser Cys Lys Asn Leu Trp Lys Ser Cys Val Glu His 
    290                 295                 300                 


His Thr Phe Phe Gln Ala Lys Lys Leu Leu Pro Gln Glu Lys Asn Val 
305                 310                 315                 320 


Leu Ser Gln Tyr Trp Thr Met Gly Ser Arg Asn Thr Lys Lys Ser Val 
                325                 330                 335     


Asn Asn Gln Tyr Cys Lys Lys Val Ile Gly Gly Met Val Trp Asn Pro 
            340                 345                 350         


Ala Met Arg Arg Ser Leu Ser Val Glu His Leu Glu Thr Lys Ser Leu 
        355                 360                 365             


Pro Ser Arg Ser Pro Pro Ile Thr Pro Asn Trp Arg Ser Pro Arg Leu 
    370                 375                 380                 


Arg His Glu Ile Arg Lys Pro Arg His Ser Ser Ala Asp Asn Leu Ala 
385                 390                 395                 400 


Asn Glu Met Thr Tyr Ile Thr Glu Thr Glu Asp Val Phe Tyr Thr Tyr 
                405                 410                 415     


Lys Gly Ser Leu Ala Pro Gln Asp Ser Asp Ser Glu Val Ser Gln Asn 
            420                 425                 430         


Arg Ser Pro His Gln Glu Ser Leu Ser Glu Asn Asn Pro Ala Gln Ser 
        435                 440                 445             


Tyr Leu Thr Gln Lys Ser Ser Ser Ser Val Ser Pro Ser Ser Asn Ala 
    450                 455                 460                 


Pro Gly Ser Cys Ser Pro Asp Gly Val Asp Gln Gln Leu Leu Asp Asp 
465                 470                 475                 480 


Phe His Arg Val Thr Lys Gly Gly Ser Thr Glu Asp Ala Ser Gln Tyr 
                485                 490                 495     


Tyr Cys Asp Lys Asn Asp Asn Gly Asp Ser Tyr Leu Val Leu Ile Arg 
            500                 505                 510         


Ile Thr Pro Asp Glu Asp Gly Lys Phe Gly Phe Asn Leu Lys Gly Gly 
        515                 520                 525             


Val Asp Gln Lys Met Pro Leu Val Val Ser Arg Ile Asn Pro Glu Ser 
    530                 535                 540                 


Pro Ala Asp Thr Cys Ile Pro Lys Leu Asn Glu Gly Asp Gln Ile Val 
545                 550                 555                 560 


Leu Ile Asn Gly Arg Asp Ile Ser Glu His Thr His Asp Gln Val Val 
                565                 570                 575     


Met Phe Ile Lys Ala Ser Arg Glu Ser His Ser Arg Glu Leu Ala Leu 
            580                 585                 590         


Val Ile Arg Arg Arg Ala Val Arg Ser Phe Ala Asp Phe Lys Ser Glu 
        595                 600                 605             


Asp Glu Leu Asn Gln Leu Phe Pro Glu Ala Ile Phe Pro Met Cys Pro 
    610                 615                 620                 


Glu Gly Gly Asp Thr Leu Glu Gly Ser Met Ala Gln Leu Lys Lys Gly 
625                 630                 635                 640 


Leu Glu Ser Gly Thr Val Leu Ile Gln Phe Glu Gln Leu Tyr Arg Lys 
                645                 650                 655     


Lys Pro Gly Leu Ala Ile Thr Phe Ala Lys Leu Pro Gln Asn Leu Asp 
            660                 665                 670         


Lys Asn Arg Tyr Lys Asp Val Leu Pro Tyr Asp Thr Thr Arg Val Leu 
        675                 680                 685             


Leu Gln Gly Asn Glu Asp Tyr Ile Asn Ala Ser Tyr Val Asn Met Glu 
    690                 695                 700                 


Ile Pro Ala Ala Asn Leu Val Asn Lys Tyr Ile Ala Thr Gln Gly Pro 
705                 710                 715                 720 


Leu Pro His Thr Cys Ala Gln Phe Trp Gln Val Val Trp Asp Gln Lys 
                725                 730                 735     


Leu Ser Leu Ile Val Met Leu Thr Thr Leu Thr Glu Arg Gly Arg Thr 
            740                 745                 750         


Lys Cys His Gln Tyr Trp Pro Asp Pro Pro Asp Val Met Asn His Gly 
        755                 760                 765             


Gly Phe His Ile Gln Cys Gln Ser Glu Asp Cys Thr Ile Ala Tyr Val 
    770                 775                 780                 


Ser Arg Glu Met Leu Val Thr Asn Thr Gln Thr Gly Glu Glu His Thr 
785                 790                 795                 800 


Val Thr His Leu Gln Tyr Val Ala Trp Pro Asp His Gly Val Pro Asp 
                805                 810                 815     


Asp Ser Ser Asp Phe Leu Glu Phe Val Asn Tyr Val Arg Ser Leu Arg 
            820                 825                 830         


Val Asp Ser Glu Pro Val Leu Val His Cys Ser Ala Gly Ile Gly Arg 
        835                 840                 845             


Thr Gly Val Leu Val Thr Met Glu Thr Ala Met Cys Leu Thr Glu Arg 
    850                 855                 860                 


Asn Leu Pro Ile Tyr Pro Leu Asp Ile Val Arg Lys Met Arg Asp Gln 
865                 870                 875                 880 


Arg Ala Met Met Val Gln Thr Ser Ser Gln Tyr Lys Phe Val Cys Glu 
                885                 890                 895     


Ala Ile Leu Arg Val Tyr Glu Glu Gly Leu Val Gln Met Leu Asp Pro 
            900                 905                 910         


Ser 
    


<210>  163
<211>  994
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (219)..(773)

<400>  163
aagactcaaa cttagaaact tgaattagat gtggtattca aatccttagc tgccgcgaag       60

acacagacag cccccgtaag aacccacgaa gcaggcgaag ttcattgttc tcaacattct      120

agctgctctt gctgcatttg ctctggaatt cttgtagaga tattacttgt ccttccaggc      180

tgttctttct gtagctccct tgttttcttt ttgtgatc atg ttg cag atg gct ggg      236
                                          Met Leu Gln Met Ala Gly         
                                          1               5               

cag tgc tcc caa aat gaa tat ttt gac agt ttg ttg cat gct tgc ata        284
Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu His Ala Cys Ile           
            10                  15                  20                    

cct tgt caa ctt cga tgt tct tct aat act cct cct cta aca tgt cag        332
Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys Gln           
        25                  30                  35                        

cgt tat tgt aat gca agt gtg acc aat tca gtg aaa gga acg aat gcg        380
Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val Lys Gly Thr Asn Ala           
    40                  45                  50                            

att ctc tgg acc tgt ttg gga ctg agc tta ata att tct ttg gca gtt        428
Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu Ile Ile Ser Leu Ala Val           
55                  60                  65                  70            

ttc gtg cta atg ttt ttg cta agg aag ata aac tct gaa cca tta aag        476
Phe Val Leu Met Phe Leu Leu Arg Lys Ile Asn Ser Glu Pro Leu Lys           
                75                  80                  85                

gac gag ttt aaa aac aca gga tca ggt ctc ctg ggc atg gct aac att        524
Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu Leu Gly Met Ala Asn Ile           
            90                  95                  100                   

gac ctg gaa aag agc agg act ggt gat gaa att att ctt ccg aga ggc        572
Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu Ile Ile Leu Pro Arg Gly           
        105                 110                 115                       

ctc gag tac acg gtg gaa gaa tgc acc tgt gaa gac tgc atc aag agc        620
Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu Asp Cys Ile Lys Ser           
    120                 125                 130                           

aaa ccg aag gtc gac tct gac cat tgc ttt cca ctc cca gct atg gag        668
Lys Pro Lys Val Asp Ser Asp His Cys Phe Pro Leu Pro Ala Met Glu           
135                 140                 145                 150           

gaa ggc gca acc att ctt gtc acc acg aaa acg aat gac tat tgc aag        716
Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr Asn Asp Tyr Cys Lys           
                155                 160                 165               

agc ctg cca gct gct ttg agt gct acg gag ata gag aaa tca att tct        764
Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu Ile Glu Lys Ser Ile Ser           
            170                 175                 180                   

gct agg taa ttaaccattt cgactcgagc agtgccactt taaaaatctt                813
Ala Arg                                                                   
                                                                          

ttgtcagaat agatgatgtg tcagatctct ttaggatgac tgtatttttc agttgccgat      873

acagcttttt gtcctctaac tgtggaaact ctttatgtta gatatatttc tctaggttac      933

tgttgggagc ttaatggtag aaacttcctt ggtttcatga ttaaactctt ttttttcctg      993

a                                                                      994


<210>  164
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210>  165
<211>  2682
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (71)..(1993)

<400>  165
ccccacccgc ttccggccgc ggctcggttc tcccgcctcc gcctccgccg cggctcgtgg       60

ttgtcccgcc atg gca ctg tcg cgg ggg ctg ccc cgg gag ctg gct gag         109
           Met Ala Leu Ser Arg Gly Leu Pro Arg Glu Leu Ala Glu            
           1               5                   10                         

gcg gtg gcc ggg ggc cgg gtg ctg gtg gtg ggg gcg ggc ggc atc ggc        157
Ala Val Ala Gly Gly Arg Val Leu Val Val Gly Ala Gly Gly Ile Gly           
    15                  20                  25                            

tgc gag ctc ctc aag aat ctc gtg ctc acc ggt ttc tcc cac atc gac        205
Cys Glu Leu Leu Lys Asn Leu Val Leu Thr Gly Phe Ser His Ile Asp           
30                  35                  40                  45            

ctg att gat ctg gat act att gat gta agc aac ctc aac aga cag ttt        253
Leu Ile Asp Leu Asp Thr Ile Asp Val Ser Asn Leu Asn Arg Gln Phe           
                50                  55                  60                

ttg ttt caa aag aaa cat gtt gga aga tca aag gca cag gtt gcc aag        301
Leu Phe Gln Lys Lys His Val Gly Arg Ser Lys Ala Gln Val Ala Lys           
            65                  70                  75                    

gaa agt gta ctg cag ttt tac ccg aaa gct aat atc gtt gcc tac cat        349
Glu Ser Val Leu Gln Phe Tyr Pro Lys Ala Asn Ile Val Ala Tyr His           
        80                  85                  90                        

gac agc atc atg aac cct gac tat aat gtg gaa ttt ttc cga cag ttt        397
Asp Ser Ile Met Asn Pro Asp Tyr Asn Val Glu Phe Phe Arg Gln Phe           
    95                  100                 105                           

ata ctg gtt atg aat gct tta gat aac aga gct gcc cga aac cat gtt        445
Ile Leu Val Met Asn Ala Leu Asp Asn Arg Ala Ala Arg Asn His Val           
110                 115                 120                 125           

aat aga atg tgc ctg gca gct gat gtt cct ctt att gaa agt gga aca        493
Asn Arg Met Cys Leu Ala Ala Asp Val Pro Leu Ile Glu Ser Gly Thr           
                130                 135                 140               

gct ggg tat ctt gga caa gta act act atc aaa aag ggt gtg acc gag        541
Ala Gly Tyr Leu Gly Gln Val Thr Thr Ile Lys Lys Gly Val Thr Glu           
            145                 150                 155                   

tgt tat gag tgt cat cct aag ccg acc cag aga acc ttt cct ggc tgt        589
Cys Tyr Glu Cys His Pro Lys Pro Thr Gln Arg Thr Phe Pro Gly Cys           
        160                 165                 170                       

aca att cgt aac aca cct tca gaa cct ata cat tgc atc gtt tgg gca        637
Thr Ile Arg Asn Thr Pro Ser Glu Pro Ile His Cys Ile Val Trp Ala           
    175                 180                 185                           

aag tac ttg ttc aac cag ttg ttt ggg gaa gaa gat gct gat caa gaa        685
Lys Tyr Leu Phe Asn Gln Leu Phe Gly Glu Glu Asp Ala Asp Gln Glu           
190                 195                 200                 205           

gta tct cct gac aga gct gac cct gaa gct gcc tgg gaa cca acg gaa        733
Val Ser Pro Asp Arg Ala Asp Pro Glu Ala Ala Trp Glu Pro Thr Glu           
                210                 215                 220               

gcc gaa gcc aga gct aga gca tct aat gaa gat ggt gac att aaa cgt        781
Ala Glu Ala Arg Ala Arg Ala Ser Asn Glu Asp Gly Asp Ile Lys Arg           
            225                 230                 235                   

att tct act aag gaa tgg gct aaa tca act gga tat gat cca gtt aaa        829
Ile Ser Thr Lys Glu Trp Ala Lys Ser Thr Gly Tyr Asp Pro Val Lys           
        240                 245                 250                       

ctt ttt acc aag ctt ttt aaa gat gac atc agg tat ctg ttg aca atg        877
Leu Phe Thr Lys Leu Phe Lys Asp Asp Ile Arg Tyr Leu Leu Thr Met           
    255                 260                 265                           

gac aaa cta tgg cgg aaa agg aaa cct cca gtt ccg ttg gac tgg gct        925
Asp Lys Leu Trp Arg Lys Arg Lys Pro Pro Val Pro Leu Asp Trp Ala           
270                 275                 280                 285           

gaa gta caa agt caa gga gaa gaa acg aat gca tca gat caa cag aat        973
Glu Val Gln Ser Gln Gly Glu Glu Thr Asn Ala Ser Asp Gln Gln Asn           
                290                 295                 300               

gaa ccc cag tta ggc ctg aaa gac cag cag gtt cta gat gta aag agc       1021
Glu Pro Gln Leu Gly Leu Lys Asp Gln Gln Val Leu Asp Val Lys Ser           
            305                 310                 315                   

tat gca cgt ctt ttt tca aag agc atc gag act ttg aga gtt cat tta       1069
Tyr Ala Arg Leu Phe Ser Lys Ser Ile Glu Thr Leu Arg Val His Leu           
        320                 325                 330                       

gca gaa aag ggg gat gga gct gag ctc ata tgg gat aag gat gac cca       1117
Ala Glu Lys Gly Asp Gly Ala Glu Leu Ile Trp Asp Lys Asp Asp Pro           
    335                 340                 345                           

tct gca atg gat ttt gtc acc tct gct gca aac ctc agg atg cat att       1165
Ser Ala Met Asp Phe Val Thr Ser Ala Ala Asn Leu Arg Met His Ile           
350                 355                 360                 365           

ttc agt atg aat atg aag agt aga ttt gat atc aaa tca atg gca ggg       1213
Phe Ser Met Asn Met Lys Ser Arg Phe Asp Ile Lys Ser Met Ala Gly           
                370                 375                 380               

aac att att cct gct att gct act act aat gca gta att gct ggg ttg       1261
Asn Ile Ile Pro Ala Ile Ala Thr Thr Asn Ala Val Ile Ala Gly Leu           
            385                 390                 395                   

ata gta ttg gaa gga ttg aag att tta tca gga aaa ata gac cag tgc       1309
Ile Val Leu Glu Gly Leu Lys Ile Leu Ser Gly Lys Ile Asp Gln Cys           
        400                 405                 410                       

aga aca att ttt ttg aat aaa caa cca aac cca aga aag aag ctt ctt       1357
Arg Thr Ile Phe Leu Asn Lys Gln Pro Asn Pro Arg Lys Lys Leu Leu           
    415                 420                 425                           

gtg cct tgt gca ctg gat cct ccc aac ccc aat tgt tat gta tgt gcc       1405
Val Pro Cys Ala Leu Asp Pro Pro Asn Pro Asn Cys Tyr Val Cys Ala           
430                 435                 440                 445           

agc aag cca gag gtg act gtg cgg ctg aat gtc cat aaa gtg act gtt       1453
Ser Lys Pro Glu Val Thr Val Arg Leu Asn Val His Lys Val Thr Val           
                450                 455                 460               

ctc acc tta caa gac aag ata gtg aaa gaa aaa ttt gct atg gta gca       1501
Leu Thr Leu Gln Asp Lys Ile Val Lys Glu Lys Phe Ala Met Val Ala           
            465                 470                 475                   

cca gat gtc caa att gaa gat ggg aaa gga aca atc cta ata tct tcc       1549
Pro Asp Val Gln Ile Glu Asp Gly Lys Gly Thr Ile Leu Ile Ser Ser           
        480                 485                 490                       

gaa gag gga gag acg gaa gct aat aat cac aag aag ttg tca gaa ttt       1597
Glu Glu Gly Glu Thr Glu Ala Asn Asn His Lys Lys Leu Ser Glu Phe           
    495                 500                 505                           

gga att aga aat ggc agc cgg ctt caa gca gat gac ttc ctc cag gac       1645
Gly Ile Arg Asn Gly Ser Arg Leu Gln Ala Asp Asp Phe Leu Gln Asp           
510                 515                 520                 525           

tat act tta ttg atc aac atc ctt cat agt gaa gac cta gga aag gac       1693
Tyr Thr Leu Leu Ile Asn Ile Leu His Ser Glu Asp Leu Gly Lys Asp           
                530                 535                 540               

gtt gaa ttt gaa gtt gtt ggt gat gcc ccg gaa aaa gtg ggg ccc aaa       1741
Val Glu Phe Glu Val Val Gly Asp Ala Pro Glu Lys Val Gly Pro Lys           
            545                 550                 555                   

caa gct gaa gat gct gcc aaa agc ata acc aat ggc agt gat gat gga       1789
Gln Ala Glu Asp Ala Ala Lys Ser Ile Thr Asn Gly Ser Asp Asp Gly           
        560                 565                 570                       

gct cag ccc tcc acc tcc aca gct caa gag caa gat gac gtt ctc ata       1837
Ala Gln Pro Ser Thr Ser Thr Ala Gln Glu Gln Asp Asp Val Leu Ile           
    575                 580                 585                           

gtt gat tca gat gaa gaa gat tct tca aat aat gcc gac gtc agt gaa       1885
Val Asp Ser Asp Glu Glu Asp Ser Ser Asn Asn Ala Asp Val Ser Glu           
590                 595                 600                 605           

gaa gag aga agc cgc aag agg aaa tta gat gag aaa gag aat ctc agt       1933
Glu Glu Arg Ser Arg Lys Arg Lys Leu Asp Glu Lys Glu Asn Leu Ser           
                610                 615                 620               

gca aag agg tca cgt ata gaa cag aag gaa gag ctt gat gat gtc ata       1981
Ala Lys Arg Ser Arg Ile Glu Gln Lys Glu Glu Leu Asp Asp Val Ile           
            625                 630                 635                   

gca tta gat tga acagaaatgc ctctaaacag aaccctctta ctatttagtt           2033
Ala Leu Asp                                                               
        640                                                               

tatctgggca gaaccagatt gttatgtcct ttgttccaaa gggaaaaaat tgacagcagt     2093

gacttgaaaa tgattctgct ccctttgaaa gcattcattt tgctagaact gttagacaca     2153

ttgcagtatg ctgtattgaa agtaggaata tagttttaaa aaccctttga acaaagtgtg     2213

tgcataacca gtcatgagat aaaacaacac aatgcatgtt gcctttttaa tgtaaatacc     2273

cgtaggtatc attaatagtt tcaaaatatt gtggtttagt aaagttgata cctggttata     2333

aatattatgc ctttattttt ggctagaaga agaattattt ttagcctaga tctaaccatt     2393

ttcatactct taactgattg aaacagattc aaagaagtat cgagtgctat gcattgaaac     2453

ttgtttttaa atgttagatg gcactatgta tattaatgta aaacaatgtt aatttactca     2513

agttttcagt ttgtaccgcc tggtatgtct gtgtaagaag ccaatttttg tgtattgtta     2573

cagtttcagg ttatttatat tcgatgtttt gtaaaactca aataacgact atacttatgg     2633

accaaataaa tggcatctgc attcttgtta caaaaaaaaa aaaaaaaaa                 2682


<210>  166
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Ala Leu Ser Arg Gly Leu Pro Arg Glu Leu Ala Glu Ala Val Ala 
1               5                   10                  15      


Gly Gly Arg Val Leu Val Val Gly Ala Gly Gly Ile Gly Cys Glu Leu 
            20                  25                  30          


Leu Lys Asn Leu Val Leu Thr Gly Phe Ser His Ile Asp Leu Ile Asp 
        35                  40                  45              


Leu Asp Thr Ile Asp Val Ser Asn Leu Asn Arg Gln Phe Leu Phe Gln 
    50                  55                  60                  


Lys Lys His Val Gly Arg Ser Lys Ala Gln Val Ala Lys Glu Ser Val 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Lys Ala Asn Ile Val Ala Tyr His Asp Ser Ile 
                85                  90                  95      


Met Asn Pro Asp Tyr Asn Val Glu Phe Phe Arg Gln Phe Ile Leu Val 
            100                 105                 110         


Met Asn Ala Leu Asp Asn Arg Ala Ala Arg Asn His Val Asn Arg Met 
        115                 120                 125             


Cys Leu Ala Ala Asp Val Pro Leu Ile Glu Ser Gly Thr Ala Gly Tyr 
    130                 135                 140                 


Leu Gly Gln Val Thr Thr Ile Lys Lys Gly Val Thr Glu Cys Tyr Glu 
145                 150                 155                 160 


Cys His Pro Lys Pro Thr Gln Arg Thr Phe Pro Gly Cys Thr Ile Arg 
                165                 170                 175     


Asn Thr Pro Ser Glu Pro Ile His Cys Ile Val Trp Ala Lys Tyr Leu 
            180                 185                 190         


Phe Asn Gln Leu Phe Gly Glu Glu Asp Ala Asp Gln Glu Val Ser Pro 
        195                 200                 205             


Asp Arg Ala Asp Pro Glu Ala Ala Trp Glu Pro Thr Glu Ala Glu Ala 
    210                 215                 220                 


Arg Ala Arg Ala Ser Asn Glu Asp Gly Asp Ile Lys Arg Ile Ser Thr 
225                 230                 235                 240 


Lys Glu Trp Ala Lys Ser Thr Gly Tyr Asp Pro Val Lys Leu Phe Thr 
                245                 250                 255     


Lys Leu Phe Lys Asp Asp Ile Arg Tyr Leu Leu Thr Met Asp Lys Leu 
            260                 265                 270         


Trp Arg Lys Arg Lys Pro Pro Val Pro Leu Asp Trp Ala Glu Val Gln 
        275                 280                 285             


Ser Gln Gly Glu Glu Thr Asn Ala Ser Asp Gln Gln Asn Glu Pro Gln 
    290                 295                 300                 


Leu Gly Leu Lys Asp Gln Gln Val Leu Asp Val Lys Ser Tyr Ala Arg 
305                 310                 315                 320 


Leu Phe Ser Lys Ser Ile Glu Thr Leu Arg Val His Leu Ala Glu Lys 
                325                 330                 335     


Gly Asp Gly Ala Glu Leu Ile Trp Asp Lys Asp Asp Pro Ser Ala Met 
            340                 345                 350         


Asp Phe Val Thr Ser Ala Ala Asn Leu Arg Met His Ile Phe Ser Met 
        355                 360                 365             


Asn Met Lys Ser Arg Phe Asp Ile Lys Ser Met Ala Gly Asn Ile Ile 
    370                 375                 380                 


Pro Ala Ile Ala Thr Thr Asn Ala Val Ile Ala Gly Leu Ile Val Leu 
385                 390                 395                 400 


Glu Gly Leu Lys Ile Leu Ser Gly Lys Ile Asp Gln Cys Arg Thr Ile 
                405                 410                 415     


Phe Leu Asn Lys Gln Pro Asn Pro Arg Lys Lys Leu Leu Val Pro Cys 
            420                 425                 430         


Ala Leu Asp Pro Pro Asn Pro Asn Cys Tyr Val Cys Ala Ser Lys Pro 
        435                 440                 445             


Glu Val Thr Val Arg Leu Asn Val His Lys Val Thr Val Leu Thr Leu 
    450                 455                 460                 


Gln Asp Lys Ile Val Lys Glu Lys Phe Ala Met Val Ala Pro Asp Val 
465                 470                 475                 480 


Gln Ile Glu Asp Gly Lys Gly Thr Ile Leu Ile Ser Ser Glu Glu Gly 
                485                 490                 495     


Glu Thr Glu Ala Asn Asn His Lys Lys Leu Ser Glu Phe Gly Ile Arg 
            500                 505                 510         


Asn Gly Ser Arg Leu Gln Ala Asp Asp Phe Leu Gln Asp Tyr Thr Leu 
        515                 520                 525             


Leu Ile Asn Ile Leu His Ser Glu Asp Leu Gly Lys Asp Val Glu Phe 
    530                 535                 540                 


Glu Val Val Gly Asp Ala Pro Glu Lys Val Gly Pro Lys Gln Ala Glu 
545                 550                 555                 560 


Asp Ala Ala Lys Ser Ile Thr Asn Gly Ser Asp Asp Gly Ala Gln Pro 
                565                 570                 575     


Ser Thr Ser Thr Ala Gln Glu Gln Asp Asp Val Leu Ile Val Asp Ser 
            580                 585                 590         


Asp Glu Glu Asp Ser Ser Asn Asn Ala Asp Val Ser Glu Glu Glu Arg 
        595                 600                 605             


Ser Arg Lys Arg Lys Leu Asp Glu Lys Glu Asn Leu Ser Ala Lys Arg 
    610                 615                 620                 


Ser Arg Ile Glu Gln Lys Glu Glu Leu Asp Asp Val Ile Ala Leu Asp 
625                 630                 635                 640 


<210>  167
<211>  18212
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (230)..(17137)

<400>  167
gaagccgcat ccagacaaaa gctgccgcat ccctgccctg cccaacccct ggagggattc       60

gagtttggtg cttgtccccg tctgattctc agcgccaaac tttttgctag ttcagagatt      120

ccaagagtct gatgagttac tctgagagga aaccctctgc ctgttgttga ggaggactga      180

gcacagtgct taggcgctga gggggaaaaa gagggggaaa aaaaagaaa atg att tcc      238
                                                      Met Ile Ser         
                                                      1                   

tgg gaa gtt gtc cat aca gta ttc ctg ttt gct ctt ctt tat tct tcc        286
Trp Glu Val Val His Thr Val Phe Leu Phe Ala Leu Leu Tyr Ser Ser           
    5                   10                  15                            

cta gct caa gat gcg agc ccc cag tca gag atc aga gct gag gaa att        334
Leu Ala Gln Asp Ala Ser Pro Gln Ser Glu Ile Arg Ala Glu Glu Ile           
20                  25                  30                  35            

ccc gag ggg gcc tcc acg ttg gct ttt gtg ttt gat gtg act ggt tct        382
Pro Glu Gly Ala Ser Thr Leu Ala Phe Val Phe Asp Val Thr Gly Ser           
                40                  45                  50                

atg tat gat gat tta gtt cag gtg att gaa ggg gct tcc aaa att ttg        430
Met Tyr Asp Asp Leu Val Gln Val Ile Glu Gly Ala Ser Lys Ile Leu           
            55                  60                  65                    

gag acg tct ttg aaa aga cct aaa aga cct ctt ttc aac ttt gcg ttg        478
Glu Thr Ser Leu Lys Arg Pro Lys Arg Pro Leu Phe Asn Phe Ala Leu           
        70                  75                  80                        

gtg cct ttc cat gat cca gaa att ggc cca gtg aca att acc aca gat        526
Val Pro Phe His Asp Pro Glu Ile Gly Pro Val Thr Ile Thr Thr Asp           
    85                  90                  95                            

ccc aag aaa ttt caa tat gaa ctc aga gaa ctg tat gtt cag ggt ggt        574
Pro Lys Lys Phe Gln Tyr Glu Leu Arg Glu Leu Tyr Val Gln Gly Gly           
100                 105                 110                 115           

ggt gat tgc cca gaa atg agt att gga gct ata aaa att gcc ttg gaa        622
Gly Asp Cys Pro Glu Met Ser Ile Gly Ala Ile Lys Ile Ala Leu Glu           
                120                 125                 130               

att tct ctt cct ggt tct ttc atc tat gtt ttc act gat gct cgg tcc        670
Ile Ser Leu Pro Gly Ser Phe Ile Tyr Val Phe Thr Asp Ala Arg Ser           
            135                 140                 145                   

aaa gat tac cgg ctc acc cat gag gtg ctg caa ctt atc caa cag aaa        718
Lys Asp Tyr Arg Leu Thr His Glu Val Leu Gln Leu Ile Gln Gln Lys           
        150                 155                 160                       

cag tca caa gtc gta ttt gtt ctg act gga gat tgt gat gac agg acc        766
Gln Ser Gln Val Val Phe Val Leu Thr Gly Asp Cys Asp Asp Arg Thr           
    165                 170                 175                           

cat att gga tat aaa gtc tat gaa gaa att gcc tct aca agt tct ggt        814
His Ile Gly Tyr Lys Val Tyr Glu Glu Ile Ala Ser Thr Ser Ser Gly           
180                 185                 190                 195           

caa gtg ttc cat ctg gac aaa aaa caa gtt aat gag gta tta aaa tgg        862
Gln Val Phe His Leu Asp Lys Lys Gln Val Asn Glu Val Leu Lys Trp           
                200                 205                 210               

gta gaa gaa gca gta cag gcc tcc aaa gtt cac ctt tta tcc aca gat        910
Val Glu Glu Ala Val Gln Ala Ser Lys Val His Leu Leu Ser Thr Asp           
            215                 220                 225                   

cat ttg gaa cag gct gta aat act tgg aga att cct ttt gat ccc agc        958
His Leu Glu Gln Ala Val Asn Thr Trp Arg Ile Pro Phe Asp Pro Ser           
        230                 235                 240                       

ctg aaa gag gtc act gtg tct ttg agt ggg cct tct cca atg att gaa       1006
Leu Lys Glu Val Thr Val Ser Leu Ser Gly Pro Ser Pro Met Ile Glu           
    245                 250                 255                           

att cgc aat cct tta ggg aag ctg ata aaa aag gga ttt ggc ctg cat       1054
Ile Arg Asn Pro Leu Gly Lys Leu Ile Lys Lys Gly Phe Gly Leu His           
260                 265                 270                 275           

gag cta tta aat atc cat aac tct gcc aaa gta gtg aat gtg aaa gag       1102
Glu Leu Leu Asn Ile His Asn Ser Ala Lys Val Val Asn Val Lys Glu           
                280                 285                 290               

cca gag gct gga atg tgg aca gtg aag acc tca agc agt gga agg cac       1150
Pro Glu Ala Gly Met Trp Thr Val Lys Thr Ser Ser Ser Gly Arg His           
            295                 300                 305                   

tct gtt cgc att act ggc ctc agt act att gat ttc cga gct ggc ttt       1198
Ser Val Arg Ile Thr Gly Leu Ser Thr Ile Asp Phe Arg Ala Gly Phe           
        310                 315                 320                       

tct cga aag ccc acc ctg gac ttc aaa aaa aca gtc agc aga cca gtg       1246
Ser Arg Lys Pro Thr Leu Asp Phe Lys Lys Thr Val Ser Arg Pro Val           
    325                 330                 335                           

caa gga ata cct acc tat gta ctg ctc aat act tct gga att tcc act       1294
Gln Gly Ile Pro Thr Tyr Val Leu Leu Asn Thr Ser Gly Ile Ser Thr           
340                 345                 350                 355           

cca gct aga ata gat ctt ctt gaa ctt ttg agt atc tca gga agt tct       1342
Pro Ala Arg Ile Asp Leu Leu Glu Leu Leu Ser Ile Ser Gly Ser Ser           
                360                 365                 370               

ctt aag act att cct gtt aaa tat tac cca cat cga aaa cct tat ggc       1390
Leu Lys Thr Ile Pro Val Lys Tyr Tyr Pro His Arg Lys Pro Tyr Gly           
            375                 380                 385                   

ata tgg aat att tct gac ttt gta cca cca aat gaa gct ttc ttt ctc       1438
Ile Trp Asn Ile Ser Asp Phe Val Pro Pro Asn Glu Ala Phe Phe Leu           
        390                 395                 400                       

aaa gta aca ggc tat gat aaa gat gat tac ctc ttc cag aga gta tca       1486
Lys Val Thr Gly Tyr Asp Lys Asp Asp Tyr Leu Phe Gln Arg Val Ser           
    405                 410                 415                           

agt gtt tcc ttt tct agt att gtc cca gat gct ccc aaa gtt acg atg       1534
Ser Val Ser Phe Ser Ser Ile Val Pro Asp Ala Pro Lys Val Thr Met           
420                 425                 430                 435           

cct gag aaa acc cca gga tac tat ctg cag ccg ggc caa att ccc tgc       1582
Pro Glu Lys Thr Pro Gly Tyr Tyr Leu Gln Pro Gly Gln Ile Pro Cys           
                440                 445                 450               

tct gtt gac agt ctt ttg ccc ttt acc ttg agc ttt gtc aga aat gga       1630
Ser Val Asp Ser Leu Leu Pro Phe Thr Leu Ser Phe Val Arg Asn Gly           
            455                 460                 465                   

gtt aca ctt gga gta gac cag tat ttg aaa gaa tct gcc agt gtg aac       1678
Val Thr Leu Gly Val Asp Gln Tyr Leu Lys Glu Ser Ala Ser Val Asn           
        470                 475                 480                       

tta gat att gca aag gtc act ttg tct gac gaa ggt ttc tat gaa tgc       1726
Leu Asp Ile Ala Lys Val Thr Leu Ser Asp Glu Gly Phe Tyr Glu Cys           
    485                 490                 495                           

att gct gtc agc agt gca ggt act gga cgg gca cag aca ttt ttt gac       1774
Ile Ala Val Ser Ser Ala Gly Thr Gly Arg Ala Gln Thr Phe Phe Asp           
500                 505                 510                 515           

gta tca gag ccc cct ccg gtc atc caa gtg cct aac aat gtt aca gtc       1822
Val Ser Glu Pro Pro Pro Val Ile Gln Val Pro Asn Asn Val Thr Val           
                520                 525                 530               

act cct gga gag aga gca gtt tta aca tgt ctc atc atc agt gcg gtg       1870
Thr Pro Gly Glu Arg Ala Val Leu Thr Cys Leu Ile Ile Ser Ala Val           
            535                 540                 545                   

gat tac aat cta acc tgg cag agg aat gac aga gat gtc aga ctg gca       1918
Asp Tyr Asn Leu Thr Trp Gln Arg Asn Asp Arg Asp Val Arg Leu Ala           
        550                 555                 560                       

gag cca gcg aga att agg acc ttg gct aat ctg tca ttg gag cta aag       1966
Glu Pro Ala Arg Ile Arg Thr Leu Ala Asn Leu Ser Leu Glu Leu Lys           
    565                 570                 575                           

agt gtg aaa ttc aac gat gct gga gag tat cat tgt atg gtt tct agt       2014
Ser Val Lys Phe Asn Asp Ala Gly Glu Tyr His Cys Met Val Ser Ser           
580                 585                 590                 595           

gaa ggt gga tca tca gcc gct tca gtt ttc ctc aca gtg caa gaa cca       2062
Glu Gly Gly Ser Ser Ala Ala Ser Val Phe Leu Thr Val Gln Glu Pro           
                600                 605                 610               

ccc aaa gtc act gtg atg ccc aag aat cag tct ttc aca gga ggg tct       2110
Pro Lys Val Thr Val Met Pro Lys Asn Gln Ser Phe Thr Gly Gly Ser           
            615                 620                 625                   

gag gtc tcc atc atg tgt tct gca aca ggt tat ccc aaa cca aag att       2158
Glu Val Ser Ile Met Cys Ser Ala Thr Gly Tyr Pro Lys Pro Lys Ile           
        630                 635                 640                       

gcc tgg acc gtt aac gat atg ttt atc gtg ggt tca cac agg tat agg       2206
Ala Trp Thr Val Asn Asp Met Phe Ile Val Gly Ser His Arg Tyr Arg           
    645                 650                 655                           

atg acc tca gat ggt acc tta ttt atc aaa aat gca gct ccc aaa gat       2254
Met Thr Ser Asp Gly Thr Leu Phe Ile Lys Asn Ala Ala Pro Lys Asp           
660                 665                 670                 675           

gca ggg atc tat ggt tgc cta gca agt aat tca gct gga aca gat aaa       2302
Ala Gly Ile Tyr Gly Cys Leu Ala Ser Asn Ser Ala Gly Thr Asp Lys           
                680                 685                 690               

cag aat tct act ctc aga tac att gaa gcc cct aag ttg atg gta gtt       2350
Gln Asn Ser Thr Leu Arg Tyr Ile Glu Ala Pro Lys Leu Met Val Val           
            695                 700                 705                   

cag agt gag ctc ttg gtt gcc ctt ggg gat ata acc gtt atg gaa tgc       2398
Gln Ser Glu Leu Leu Val Ala Leu Gly Asp Ile Thr Val Met Glu Cys           
        710                 715                 720                       

aaa acc tct ggt att cct cca cct caa gtt aaa tgg ttc aaa gga gat       2446
Lys Thr Ser Gly Ile Pro Pro Pro Gln Val Lys Trp Phe Lys Gly Asp           
    725                 730                 735                           

ctt gag ttg agg ccc tca aca ttc ctc att att gac cct ctc ttg gga       2494
Leu Glu Leu Arg Pro Ser Thr Phe Leu Ile Ile Asp Pro Leu Leu Gly           
740                 745                 750                 755           

ctt ttg aag att caa gaa aca caa gat ctg gat gct ggc gat tat acc       2542
Leu Leu Lys Ile Gln Glu Thr Gln Asp Leu Asp Ala Gly Asp Tyr Thr           
                760                 765                 770               

tgt gta gcc atc aat gag gct gga aga gca act ggc aag ata act ctg       2590
Cys Val Ala Ile Asn Glu Ala Gly Arg Ala Thr Gly Lys Ile Thr Leu           
            775                 780                 785                   

gat gtt ggc tca cct cca gtt ttc ata caa gaa cct gct gat gtg tct       2638
Asp Val Gly Ser Pro Pro Val Phe Ile Gln Glu Pro Ala Asp Val Ser           
        790                 795                 800                       

atg gaa att ggc tca aat gtg aca tta cct tgt tat gtt cag ggt tat       2686
Met Glu Ile Gly Ser Asn Val Thr Leu Pro Cys Tyr Val Gln Gly Tyr           
    805                 810                 815                           

cca gaa cca aca atc aaa tgg cga aga tta gac aac atg cca att ttc       2734
Pro Glu Pro Thr Ile Lys Trp Arg Arg Leu Asp Asn Met Pro Ile Phe           
820                 825                 830                 835           

tca aga cct ttt tca gtt agt tcc atc agc caa cta aga aca gga gct       2782
Ser Arg Pro Phe Ser Val Ser Ser Ile Ser Gln Leu Arg Thr Gly Ala           
                840                 845                 850               

ctc ttt att tta aac tta tgg gca agt gat aaa gga acc tat att tgt       2830
Leu Phe Ile Leu Asn Leu Trp Ala Ser Asp Lys Gly Thr Tyr Ile Cys           
            855                 860                 865                   

gaa gct gaa aac cag ttt gga aag atc cag tca gag aca aca gta aca       2878
Glu Ala Glu Asn Gln Phe Gly Lys Ile Gln Ser Glu Thr Thr Val Thr           
        870                 875                 880                       

gtg acc gga ctt gtt gct cca ctt att gga atc agc cct tca gtg gcc       2926
Val Thr Gly Leu Val Ala Pro Leu Ile Gly Ile Ser Pro Ser Val Ala           
    885                 890                 895                           

aat gtt att gaa gga cag cag ctt act ttg ccc tgt act ctg tta gct       2974
Asn Val Ile Glu Gly Gln Gln Leu Thr Leu Pro Cys Thr Leu Leu Ala           
900                 905                 910                 915           

gga aat ccc att cca gaa cgt cgg tgg att aag aat tca gct atg ttg       3022
Gly Asn Pro Ile Pro Glu Arg Arg Trp Ile Lys Asn Ser Ala Met Leu           
                920                 925                 930               

ctc caa aat cct tac atc act gtg cgc agt gat ggg agc ctc cat att       3070
Leu Gln Asn Pro Tyr Ile Thr Val Arg Ser Asp Gly Ser Leu His Ile           
            935                 940                 945                   

gaa aga gtt cag ctt cag gat ggt ggt gaa tat act tgt gtg gcc agt       3118
Glu Arg Val Gln Leu Gln Asp Gly Gly Glu Tyr Thr Cys Val Ala Ser           
        950                 955                 960                       

aac gtt gct ggg acc aat aac aaa act acc tct gtg gtt gtg cat gtt       3166
Asn Val Ala Gly Thr Asn Asn Lys Thr Thr Ser Val Val Val His Val           
    965                 970                 975                           

ctg cca acc att cag cat ggg cag cag ata ctc agt aca att gaa ggc       3214
Leu Pro Thr Ile Gln His Gly Gln Gln Ile Leu Ser Thr Ile Glu Gly           
980                 985                 990                 995           

att cca gta act tta  cca tgc aaa gca agt  gga aat ccc aaa ccg         3259
Ile Pro Val Thr Leu  Pro Cys Lys Ala Ser  Gly Asn Pro Lys Pro             
                1000                 1005                 1010            

tct gtc atc tgg tcc  aag aaa gga gag ctg  att tca acc agc agt         3304
Ser Val Ile Trp Ser  Lys Lys Gly Glu Leu  Ile Ser Thr Ser Ser             
                1015                 1020                 1025            

gct aag ttt tca gca  gga gct gat ggt agt  ctg tat gtg gta tca         3349
Ala Lys Phe Ser Ala  Gly Ala Asp Gly Ser  Leu Tyr Val Val Ser             
                1030                 1035                 1040            

cct gga gga gag gag  agt ggg gag tat gtc  tgc act gcc acc aat         3394
Pro Gly Gly Glu Glu  Ser Gly Glu Tyr Val  Cys Thr Ala Thr Asn             
                1045                 1050                 1055            

aca gcc ggc tac gcc  aaa agg aaa gtg cag  cta aca gtc tat gta         3439
Thr Ala Gly Tyr Ala  Lys Arg Lys Val Gln  Leu Thr Val Tyr Val             
                1060                 1065                 1070            

agg ccc aga gtg ttt  gga gat caa cga gga  ctg tcc cag gat aag         3484
Arg Pro Arg Val Phe  Gly Asp Gln Arg Gly  Leu Ser Gln Asp Lys             
                1075                 1080                 1085            

cct gtt gag atc tcc  gtc ctt gca ggg gaa  gag gta aca ctt cca         3529
Pro Val Glu Ile Ser  Val Leu Ala Gly Glu  Glu Val Thr Leu Pro             
                1090                 1095                 1100            

tgt gaa gtg aag agc  tta cct cca ccc ata  att act tgg gcc aaa         3574
Cys Glu Val Lys Ser  Leu Pro Pro Pro Ile  Ile Thr Trp Ala Lys             
                1105                 1110                 1115            

gaa acc cag ctc atc  tca ccg ttc tct cca  aga cac aca ttc ctc         3619
Glu Thr Gln Leu Ile  Ser Pro Phe Ser Pro  Arg His Thr Phe Leu             
                1120                 1125                 1130            

cct tct ggt tca atg  aag atc act gaa acc  cgc act tca gat agt         3664
Pro Ser Gly Ser Met  Lys Ile Thr Glu Thr  Arg Thr Ser Asp Ser             
                1135                 1140                 1145            

ggg atg tat ctt tgt  gtt gcc aca aat att  gct ggg aat gtg act         3709
Gly Met Tyr Leu Cys  Val Ala Thr Asn Ile  Ala Gly Asn Val Thr             
                1150                 1155                 1160            

cag gct gtc aaa tta  aat gtc cat gtt cct  cca aag ata cag cgt         3754
Gln Ala Val Lys Leu  Asn Val His Val Pro  Pro Lys Ile Gln Arg             
                1165                 1170                 1175            

gga cct aaa cat ctc  aaa gtc caa gtt ggt  caa aga gtg gat att         3799
Gly Pro Lys His Leu  Lys Val Gln Val Gly  Gln Arg Val Asp Ile             
                1180                 1185                 1190            

cca tgt aat gct caa  ggg act cct ctt cct  gta atc acc tgg tcc         3844
Pro Cys Asn Ala Gln  Gly Thr Pro Leu Pro  Val Ile Thr Trp Ser             
                1195                 1200                 1205            

aaa ggt gga agc act  atg ctg gtt gat gga  gag cac cat gtt agc         3889
Lys Gly Gly Ser Thr  Met Leu Val Asp Gly  Glu His His Val Ser             
                1210                 1215                 1220            

aat cca gac gga act  tta agc atc gac caa  gcc acg ccc tca gat         3934
Asn Pro Asp Gly Thr  Leu Ser Ile Asp Gln  Ala Thr Pro Ser Asp             
                1225                 1230                 1235            

gct ggc ata tat aca  tgt gtt gct act aac  ata gca ggc act gat         3979
Ala Gly Ile Tyr Thr  Cys Val Ala Thr Asn  Ile Ala Gly Thr Asp             
                1240                 1245                 1250            

gaa aca gag ata acg  cta cat gtc caa gaa  cca ccc aca gtg gaa         4024
Glu Thr Glu Ile Thr  Leu His Val Gln Glu  Pro Pro Thr Val Glu             
                1255                 1260                 1265            

gat cta gaa cct cca  tat aac act act ttc  caa gaa aga gtg gcc         4069
Asp Leu Glu Pro Pro  Tyr Asn Thr Thr Phe  Gln Glu Arg Val Ala             
                1270                 1275                 1280            

aat caa cgc att gaa  ttt cca tgt cct gca  aaa ggt acc cct aaa         4114
Asn Gln Arg Ile Glu  Phe Pro Cys Pro Ala  Lys Gly Thr Pro Lys             
                1285                 1290                 1295            

cca acc atc aaa tgg  tta cac aat ggt aga  gag ttg aca ggc aga         4159
Pro Thr Ile Lys Trp  Leu His Asn Gly Arg  Glu Leu Thr Gly Arg             
                1300                 1305                 1310            

gag cct ggc att tct  atc ttg gaa gat ggc  aca ttg ctg gtt att         4204
Glu Pro Gly Ile Ser  Ile Leu Glu Asp Gly  Thr Leu Leu Val Ile             
                1315                 1320                 1325            

gct tct gtt aca ccc  tat gac aat ggg gag  tac atc tgt gtg gca         4249
Ala Ser Val Thr Pro  Tyr Asp Asn Gly Glu  Tyr Ile Cys Val Ala             
                1330                 1335                 1340            

gtc aat gaa gct gga  acc aca gaa aga aaa  tat aac ctc aaa gtc         4294
Val Asn Glu Ala Gly  Thr Thr Glu Arg Lys  Tyr Asn Leu Lys Val             
                1345                 1350                 1355            

cat gtt cct cca gta  att aaa gat aaa gaa  caa gtt aca aat gtg         4339
His Val Pro Pro Val  Ile Lys Asp Lys Glu  Gln Val Thr Asn Val             
                1360                 1365                 1370            

tcg gtg ttg tta aat  cag ctg acc aat ctc  ttc tgt gaa gtg gaa         4384
Ser Val Leu Leu Asn  Gln Leu Thr Asn Leu  Phe Cys Glu Val Glu             
                1375                 1380                 1385            

ggc act cca tct ccc  atc att atg tgg tat  aaa gat aat gtc cag         4429
Gly Thr Pro Ser Pro  Ile Ile Met Trp Tyr  Lys Asp Asn Val Gln             
                1390                 1395                 1400            

gtg act gaa agc agc  act att cag act gtg  aac aat ggg aag ata         4474
Val Thr Glu Ser Ser  Thr Ile Gln Thr Val  Asn Asn Gly Lys Ile             
                1405                 1410                 1415            

ctg aag ctc ttc aga  gcc act cca gag gat  gca gga aga tat tcc         4519
Leu Lys Leu Phe Arg  Ala Thr Pro Glu Asp  Ala Gly Arg Tyr Ser             
                1420                 1425                 1430            

tgc aaa gca att aat  att gca ggc act tct  cag aag tac ttt aac         4564
Cys Lys Ala Ile Asn  Ile Ala Gly Thr Ser  Gln Lys Tyr Phe Asn             
                1435                 1440                 1445            

att gat gtg cta gtt  cca ccc acc ata ata  ggt acc aac ttc cca         4609
Ile Asp Val Leu Val  Pro Pro Thr Ile Ile  Gly Thr Asn Phe Pro             
                1450                 1455                 1460            

aat gaa gtc tca gtt  gtc ctc aac cgt gac  gtc gcc ctt gaa tgc         4654
Asn Glu Val Ser Val  Val Leu Asn Arg Asp  Val Ala Leu Glu Cys             
                1465                 1470                 1475            

cag gtc aaa ggc act  ccc ttt cct gat att  cat tgg ttc aaa gat         4699
Gln Val Lys Gly Thr  Pro Phe Pro Asp Ile  His Trp Phe Lys Asp             
                1480                 1485                 1490            

ggc aag cct tta ttt  ttg ggc gat cct aat  gtt gaa ctt cta gac         4744
Gly Lys Pro Leu Phe  Leu Gly Asp Pro Asn  Val Glu Leu Leu Asp             
                1495                 1500                 1505            

aga gga caa gtc tta  cat tta aag aat gca  cgg aga aat gac aag         4789
Arg Gly Gln Val Leu  His Leu Lys Asn Ala  Arg Arg Asn Asp Lys             
                1510                 1515                 1520            

ggg cgc tac caa tgt  act gtg tct aat gca  gct ggc aaa caa gcc         4834
Gly Arg Tyr Gln Cys  Thr Val Ser Asn Ala  Ala Gly Lys Gln Ala             
                1525                 1530                 1535            

aag gat ata aaa ctg  act atc tat att cca  cct agt att aaa gga         4879
Lys Asp Ile Lys Leu  Thr Ile Tyr Ile Pro  Pro Ser Ile Lys Gly             
                1540                 1545                 1550            

gga aat gtc acc aca  gac ata tca gta ttg  atc aac agc ctt att         4924
Gly Asn Val Thr Thr  Asp Ile Ser Val Leu  Ile Asn Ser Leu Ile             
                1555                 1560                 1565            

aaa ctg gaa tgt gaa  aca cgg gga ctt cca  atg cct gcc att act         4969
Lys Leu Glu Cys Glu  Thr Arg Gly Leu Pro  Met Pro Ala Ile Thr             
                1570                 1575                 1580            

tgg tat aag gac ggg  cag cca atc atg tcc  agc tca caa gca ctt         5014
Trp Tyr Lys Asp Gly  Gln Pro Ile Met Ser  Ser Ser Gln Ala Leu             
                1585                 1590                 1595            

tat att gat aaa gga  caa tat ctt cat att  cct cga gca cag gtc         5059
Tyr Ile Asp Lys Gly  Gln Tyr Leu His Ile  Pro Arg Ala Gln Val             
                1600                 1605                 1610            

tct gat tca gca aca  tat acg tgt cat gta  gcc aat gtt gct gga         5104
Ser Asp Ser Ala Thr  Tyr Thr Cys His Val  Ala Asn Val Ala Gly             
                1615                 1620                 1625            

act gct gaa aaa tca  ttc cat gtg gat gtc  tat gtt cct cca atg         5149
Thr Ala Glu Lys Ser  Phe His Val Asp Val  Tyr Val Pro Pro Met             
                1630                 1635                 1640            

att gaa ggc aac ttg  gcc acg cct ttg aat  aag caa gta gtt att         5194
Ile Glu Gly Asn Leu  Ala Thr Pro Leu Asn  Lys Gln Val Val Ile             
                1645                 1650                 1655            

gct cat tct ctg aca  ctg gag tgc aaa gct  gct gga aac cct tct         5239
Ala His Ser Leu Thr  Leu Glu Cys Lys Ala  Ala Gly Asn Pro Ser             
                1660                 1665                 1670            

ccc att ctc acc tgg  ttg aaa gat ggt gta  cct gtg aaa gct aat         5284
Pro Ile Leu Thr Trp  Leu Lys Asp Gly Val  Pro Val Lys Ala Asn             
                1675                 1680                 1685            

gac aat atc cgc ata  gaa gct ggt ggg aag  aaa ctc gaa atc atg         5329
Asp Asn Ile Arg Ile  Glu Ala Gly Gly Lys  Lys Leu Glu Ile Met             
                1690                 1695                 1700            

agt gcc caa gaa att  gat cga gga cag tac  ata tgc gtg gct acc         5374
Ser Ala Gln Glu Ile  Asp Arg Gly Gln Tyr  Ile Cys Val Ala Thr             
                1705                 1710                 1715            

agt gtg gca gga gaa  aag gaa atc aaa tat  gaa gtt gat gtc ttg         5419
Ser Val Ala Gly Glu  Lys Glu Ile Lys Tyr  Glu Val Asp Val Leu             
                1720                 1725                 1730            

gtg cca cca gct ata  gaa gga gga gat gaa  aca tct tac ttc att         5464
Val Pro Pro Ala Ile  Glu Gly Gly Asp Glu  Thr Ser Tyr Phe Ile             
                1735                 1740                 1745            

gtg atg gtt aat aac  tta ctg gag cta gat  tgt cat gtg aca ggc         5509
Val Met Val Asn Asn  Leu Leu Glu Leu Asp  Cys His Val Thr Gly             
                1750                 1755                 1760            

tct ccc cca cca act  atc atg tgg ctg aag  gat ggc cag tta att         5554
Ser Pro Pro Pro Thr  Ile Met Trp Leu Lys  Asp Gly Gln Leu Ile             
                1765                 1770                 1775            

gat gaa agg gat gga  ttc aag att tta tta  aat gga cgc aaa ctg         5599
Asp Glu Arg Asp Gly  Phe Lys Ile Leu Leu  Asn Gly Arg Lys Leu             
                1780                 1785                 1790            

gtt att gct cag gct  caa gtg tca aac aca  ggc ctt tat cgg tgc         5644
Val Ile Ala Gln Ala  Gln Val Ser Asn Thr  Gly Leu Tyr Arg Cys             
                1795                 1800                 1805            

atg gca gca aat act  gct gga gac cac aag  aag gaa ttt gaa gtg         5689
Met Ala Ala Asn Thr  Ala Gly Asp His Lys  Lys Glu Phe Glu Val             
                1810                 1815                 1820            

act gtt cat gtt cct  cca aca atc aag tcc  tca ggc ctt tct gag         5734
Thr Val His Val Pro  Pro Thr Ile Lys Ser  Ser Gly Leu Ser Glu             
                1825                 1830                 1835            

aga gtt gtg gta aaa  tac aag cct gtc gcc  ttg cag tgc ata gcc         5779
Arg Val Val Val Lys  Tyr Lys Pro Val Ala  Leu Gln Cys Ile Ala             
                1840                 1845                 1850            

aat ggg att cca aat  cct tcc att aca tgg  tta aaa gat gac cag         5824
Asn Gly Ile Pro Asn  Pro Ser Ile Thr Trp  Leu Lys Asp Asp Gln             
                1855                 1860                 1865            

cct gtg aac act gcc  caa gga aac ctt aaa  ata cag tct tct ggt         5869
Pro Val Asn Thr Ala  Gln Gly Asn Leu Lys  Ile Gln Ser Ser Gly             
                1870                 1875                 1880            

cga gtt cta caa att  gcc aaa acc ctg ttg  gaa gat gct ggc aga         5914
Arg Val Leu Gln Ile  Ala Lys Thr Leu Leu  Glu Asp Ala Gly Arg             
                1885                 1890                 1895            

tac aca tgt gtg gct  acc aac gca gct gga  gaa aca caa cag cac         5959
Tyr Thr Cys Val Ala  Thr Asn Ala Ala Gly  Glu Thr Gln Gln His             
                1900                 1905                 1910            

att caa ctg cat gtt  cat gaa cca cct agt  ctg gaa gat gct gga         6004
Ile Gln Leu His Val  His Glu Pro Pro Ser  Leu Glu Asp Ala Gly             
                1915                 1920                 1925            

aaa atg ctg aat gag  act gtg ttg gtg agc  aac cct gta cag ctg         6049
Lys Met Leu Asn Glu  Thr Val Leu Val Ser  Asn Pro Val Gln Leu             
                1930                 1935                 1940            

gag tgt aag gca gct  gga aat cct gtg cct  gtt att aca tgg tac         6094
Glu Cys Lys Ala Ala  Gly Asn Pro Val Pro  Val Ile Thr Trp Tyr             
                1945                 1950                 1955            

aaa gat aat cgt cta  ctc tca ggt tcc acc  agc atg act ttc ttg         6139
Lys Asp Asn Arg Leu  Leu Ser Gly Ser Thr  Ser Met Thr Phe Leu             
                1960                 1965                 1970            

aac aga gga cag atc  att gat att gaa agt  gcc cag atc tca gat         6184
Asn Arg Gly Gln Ile  Ile Asp Ile Glu Ser  Ala Gln Ile Ser Asp             
                1975                 1980                 1985            

gct ggc ata tat aaa  tgc gtg gcc atc aac  tca gct gga gct aca         6229
Ala Gly Ile Tyr Lys  Cys Val Ala Ile Asn  Ser Ala Gly Ala Thr             
                1990                 1995                 2000            

gag tta ttt tac agt  ctg caa gtt cat gtg  gcc cca tca att tct         6274
Glu Leu Phe Tyr Ser  Leu Gln Val His Val  Ala Pro Ser Ile Ser             
                2005                 2010                 2015            

ggc agc aat aac atg  gtg gca gtg gtg gtt  aat aac ccg gtg agg         6319
Gly Ser Asn Asn Met  Val Ala Val Val Val  Asn Asn Pro Val Arg             
                2020                 2025                 2030            

tta gaa tgt gaa gcc  aga ggt att cct gcc  cca agt ctg acc tgg         6364
Leu Glu Cys Glu Ala  Arg Gly Ile Pro Ala  Pro Ser Leu Thr Trp             
                2035                 2040                 2045            

ttg aaa gat ggg agt  cct gtt tct agt ttt  tct aat gga tta cag         6409
Leu Lys Asp Gly Ser  Pro Val Ser Ser Phe  Ser Asn Gly Leu Gln             
                2050                 2055                 2060            

gtt ctc tct ggt ggt  cga atc cta gca ttg  acc agt gca caa atc         6454
Val Leu Ser Gly Gly  Arg Ile Leu Ala Leu  Thr Ser Ala Gln Ile             
                2065                 2070                 2075            

agc gac aca gga agg  tac acc tgc gtg gca  gtg aat gct gct gga         6499
Ser Asp Thr Gly Arg  Tyr Thr Cys Val Ala  Val Asn Ala Ala Gly             
                2080                 2085                 2090            

gaa aag caa agg gac  att gac ctc cga gta  tat gtt ccg cca aat         6544
Glu Lys Gln Arg Asp  Ile Asp Leu Arg Val  Tyr Val Pro Pro Asn             
                2095                 2100                 2105            

att atg gga gaa gaa  cag aat gtc tct gtc  ctc att agc caa gct         6589
Ile Met Gly Glu Glu  Gln Asn Val Ser Val  Leu Ile Ser Gln Ala             
                2110                 2115                 2120            

gtg gaa tta cta tgt  caa agt gat gct att  ccc cca cct act ctt         6634
Val Glu Leu Leu Cys  Gln Ser Asp Ala Ile  Pro Pro Pro Thr Leu             
                2125                 2130                 2135            

act tgg tta aaa gac  ggc cac ccc ttg ctg  aag aaa cca ggc ctc         6679
Thr Trp Leu Lys Asp  Gly His Pro Leu Leu  Lys Lys Pro Gly Leu             
                2140                 2145                 2150            

agt ata tct gaa aat  aga agt gtg tta aag  att gaa gat gct cag         6724
Ser Ile Ser Glu Asn  Arg Ser Val Leu Lys  Ile Glu Asp Ala Gln             
                2155                 2160                 2165            

gtt caa gac act ggt  cgt tac act tgt gaa  gca aca aat gtt gct         6769
Val Gln Asp Thr Gly  Arg Tyr Thr Cys Glu  Ala Thr Asn Val Ala             
                2170                 2175                 2180            

gga aaa act gaa aaa  aac tac aat gtc aac  att tgg gtc ccc cca         6814
Gly Lys Thr Glu Lys  Asn Tyr Asn Val Asn  Ile Trp Val Pro Pro             
                2185                 2190                 2195            

aat att ggt ggt tct  gat gaa ctt act caa  ctt aca gtc att gaa         6859
Asn Ile Gly Gly Ser  Asp Glu Leu Thr Gln  Leu Thr Val Ile Glu             
                2200                 2205                 2210            

ggg aat ctc att agt  ctg ttg tgt gaa tca  agt ggt att cca ccc         6904
Gly Asn Leu Ile Ser  Leu Leu Cys Glu Ser  Ser Gly Ile Pro Pro             
                2215                 2220                 2225            

cca aat ctc atc tgg  aag aag aaa ggc tct  cca gtg ctg act gat         6949
Pro Asn Leu Ile Trp  Lys Lys Lys Gly Ser  Pro Val Leu Thr Asp             
                2230                 2235                 2240            

tcc atg ggg cga gtt  aga att tta tct ggg  ggc agg caa tta caa         6994
Ser Met Gly Arg Val  Arg Ile Leu Ser Gly  Gly Arg Gln Leu Gln             
                2245                 2250                 2255            

att tca att gct gaa  aag tct gat gca gca  ctc tat tca tgt gtg         7039
Ile Ser Ile Ala Glu  Lys Ser Asp Ala Ala  Leu Tyr Ser Cys Val             
                2260                 2265                 2270            

gcg tcg aat gtt gct  ggg act gca aag aaa  gaa tac aat ctg caa         7084
Ala Ser Asn Val Ala  Gly Thr Ala Lys Lys  Glu Tyr Asn Leu Gln             
                2275                 2280                 2285            

gtt tac att aga cca  acc ata acc aac agt  ggc agc cac cct act         7129
Val Tyr Ile Arg Pro  Thr Ile Thr Asn Ser  Gly Ser His Pro Thr             
                2290                 2295                 2300            

gaa att att gtg acc  cga ggg aag agt atc  tcc ttg gag tgt gag         7174
Glu Ile Ile Val Thr  Arg Gly Lys Ser Ile  Ser Leu Glu Cys Glu             
                2305                 2310                 2315            

gtg cag ggt att cca  cca cca aca gtg acc  tgg atg aaa gat ggc         7219
Val Gln Gly Ile Pro  Pro Pro Thr Val Thr  Trp Met Lys Asp Gly             
                2320                 2325                 2330            

cac ccc ttg atc aag  gca aag gga gta gaa  ata ctg gat gaa ggt         7264
His Pro Leu Ile Lys  Ala Lys Gly Val Glu  Ile Leu Asp Glu Gly             
                2335                 2340                 2345            

cac atc ctt cag ctg  aag aac att cat gta  tct gac aca ggc cgt         7309
His Ile Leu Gln Leu  Lys Asn Ile His Val  Ser Asp Thr Gly Arg             
                2350                 2355                 2360            

tat gtg tgt gtt gct  gtg aat gta gca gga  atg act gac aaa aaa         7354
Tyr Val Cys Val Ala  Val Asn Val Ala Gly  Met Thr Asp Lys Lys             
                2365                 2370                 2375            

tat gac tta agt gtc  cat gct cct cca agc  atc ata gga aac cac         7399
Tyr Asp Leu Ser Val  His Ala Pro Pro Ser  Ile Ile Gly Asn His             
                2380                 2385                 2390            

agg tca cct gaa aat  att agt gtg gta gaa  aag aac tca gta tct         7444
Arg Ser Pro Glu Asn  Ile Ser Val Val Glu  Lys Asn Ser Val Ser             
                2395                 2400                 2405            

ttg act tgt gaa gct  tct gga att ccc ctg  cct tcc ata acc tgg         7489
Leu Thr Cys Glu Ala  Ser Gly Ile Pro Leu  Pro Ser Ile Thr Trp             
                2410                 2415                 2420            

ttc aaa gat ggg tgg  cct gtc agc ctt agc  aat tct gtg agg att         7534
Phe Lys Asp Gly Trp  Pro Val Ser Leu Ser  Asn Ser Val Arg Ile             
                2425                 2430                 2435            

ctt tca gga ggc agg  atg cta cgg ctg atg  cag acc aca atg gaa         7579
Leu Ser Gly Gly Arg  Met Leu Arg Leu Met  Gln Thr Thr Met Glu             
                2440                 2445                 2450            

gat gct ggc caa tat  act tgc gtt gta agg  aat gca gct ggt gaa         7624
Asp Ala Gly Gln Tyr  Thr Cys Val Val Arg  Asn Ala Ala Gly Glu             
                2455                 2460                 2465            

gaa aga aaa atc ttt  ggg ctt tca gta tta  gta cca cct cat att         7669
Glu Arg Lys Ile Phe  Gly Leu Ser Val Leu  Val Pro Pro His Ile             
                2470                 2475                 2480            

gtg ggt gaa aat aca  ttg gaa gat gtg aag  gta aaa gag aaa cag         7714
Val Gly Glu Asn Thr  Leu Glu Asp Val Lys  Val Lys Glu Lys Gln             
                2485                 2490                 2495            

agt gtt acg ctg act  tgt gaa gtg aca ggg  aat cca gtg cca gaa         7759
Ser Val Thr Leu Thr  Cys Glu Val Thr Gly  Asn Pro Val Pro Glu             
                2500                 2505                 2510            

att aca tgg cac aaa  gat ggg cag ccc ctc  caa gaa gat gaa gcc         7804
Ile Thr Trp His Lys  Asp Gly Gln Pro Leu  Gln Glu Asp Glu Ala             
                2515                 2520                 2525            

cat cac att ata tct  ggt ggc cgt ttt ctt  caa att acc aat gtc         7849
His His Ile Ile Ser  Gly Gly Arg Phe Leu  Gln Ile Thr Asn Val             
                2530                 2535                 2540            

cag gtg cca cac act  gga aga tat aca tgt  ttg gct tcc agt cca         7894
Gln Val Pro His Thr  Gly Arg Tyr Thr Cys  Leu Ala Ser Ser Pro             
                2545                 2550                 2555            

gct ggc cac aag agc  agg agc ttc agt ctt  aat gta ttt gta tct         7939
Ala Gly His Lys Ser  Arg Ser Phe Ser Leu  Asn Val Phe Val Ser             
                2560                 2565                 2570            

cct aca att gct ggt  gta ggt agt gat ggc  aac cct gaa gat gtc         7984
Pro Thr Ile Ala Gly  Val Gly Ser Asp Gly  Asn Pro Glu Asp Val             
                2575                 2580                 2585            

act gtc atc ctt aac  agc cct aca tct ttg  gtc tgt gaa gct tat         8029
Thr Val Ile Leu Asn  Ser Pro Thr Ser Leu  Val Cys Glu Ala Tyr             
                2590                 2595                 2600            

tca tat cct cca gct  acc atc acc tgg ttt  aag gat ggc act cct         8074
Ser Tyr Pro Pro Ala  Thr Ile Thr Trp Phe  Lys Asp Gly Thr Pro             
                2605                 2610                 2615            

tta gaa tct aac cga  aat att cgt att ctt  cca gga ggc aga act         8119
Leu Glu Ser Asn Arg  Asn Ile Arg Ile Leu  Pro Gly Gly Arg Thr             
                2620                 2625                 2630            

ctg cag atc ctc aat  gca cag gag gac aat  gct gga aga tac tct         8164
Leu Gln Ile Leu Asn  Ala Gln Glu Asp Asn  Ala Gly Arg Tyr Ser             
                2635                 2640                 2645            

tgt gta gcc acg aat  gag gct gga gaa atg  ata aag cac tat gaa         8209
Cys Val Ala Thr Asn  Glu Ala Gly Glu Met  Ile Lys His Tyr Glu             
                2650                 2655                 2660            

gtg aag gtg tac att  cca ccc ata atc aat  aaa ggg gac ctt tgg         8254
Val Lys Val Tyr Ile  Pro Pro Ile Ile Asn  Lys Gly Asp Leu Trp             
                2665                 2670                 2675            

ggg cca ggt ctt tcc  cct aaa gaa gtg aag  atc aaa gta aac aac         8299
Gly Pro Gly Leu Ser  Pro Lys Glu Val Lys  Ile Lys Val Asn Asn             
                2680                 2685                 2690            

act ctg acc ttg gaa  tgt gaa gcg tat gca  att cct tct gcc tcc         8344
Thr Leu Thr Leu Glu  Cys Glu Ala Tyr Ala  Ile Pro Ser Ala Ser             
                2695                 2700                 2705            

ctc agc tgg tac aag  gat gga cag ccc ctt  aaa tcc gat gat cat         8389
Leu Ser Trp Tyr Lys  Asp Gly Gln Pro Leu  Lys Ser Asp Asp His             
                2710                 2715                 2720            

gtt aat att gct gcg  aat gga cac aca ctt  caa ata aag gag gct         8434
Val Asn Ile Ala Ala  Asn Gly His Thr Leu  Gln Ile Lys Glu Ala             
                2725                 2730                 2735            

caa ata tca gac acc  gga cga tat act tgt  gta gca tct aac att         8479
Gln Ile Ser Asp Thr  Gly Arg Tyr Thr Cys  Val Ala Ser Asn Ile             
                2740                 2745                 2750            

gca ggt gaa gat gag  ttg gat ttt gat gtg  aat att caa gtt cct         8524
Ala Gly Glu Asp Glu  Leu Asp Phe Asp Val  Asn Ile Gln Val Pro             
                2755                 2760                 2765            

cca agt ttt cag aaa  ctc tgg gaa ata gga  aac atg cta gat act         8569
Pro Ser Phe Gln Lys  Leu Trp Glu Ile Gly  Asn Met Leu Asp Thr             
                2770                 2775                 2780            

ggc agg aat ggt gaa  gcc aaa gat gtg atc  atc aac aat ccc att         8614
Gly Arg Asn Gly Glu  Ala Lys Asp Val Ile  Ile Asn Asn Pro Ile             
                2785                 2790                 2795            

tct ctt tac tgt gag  aca aat gct gct ccc  cct cct aca ctg aca         8659
Ser Leu Tyr Cys Glu  Thr Asn Ala Ala Pro  Pro Pro Thr Leu Thr             
                2800                 2805                 2810            

tgg tac aaa gat ggc  cac cct ctg acc tca  agt gat aaa gta ttg         8704
Trp Tyr Lys Asp Gly  His Pro Leu Thr Ser  Ser Asp Lys Val Leu             
                2815                 2820                 2825            

att ttg cca gga ggg  cga gtg ttg cag att  cct cgg gct aaa gta         8749
Ile Leu Pro Gly Gly  Arg Val Leu Gln Ile  Pro Arg Ala Lys Val             
                2830                 2835                 2840            

gaa gat gct ggg aga  tac aca tgt gtg gct  gtg aat gag gct gga         8794
Glu Asp Ala Gly Arg  Tyr Thr Cys Val Ala  Val Asn Glu Ala Gly             
                2845                 2850                 2855            

gaa gat tcc ctt caa  tat gat gtc cgt gta  ctc gtg ccg cca att         8839
Glu Asp Ser Leu Gln  Tyr Asp Val Arg Val  Leu Val Pro Pro Ile             
                2860                 2865                 2870            

atc aag gga gca aat  agt gat ctc cct gaa  gag gtc acc gtg ctg         8884
Ile Lys Gly Ala Asn  Ser Asp Leu Pro Glu  Glu Val Thr Val Leu             
                2875                 2880                 2885            

gtg aac aag agt gca  ctg ata gag tgt tta  tcc agt ggc agc cca         8929
Val Asn Lys Ser Ala  Leu Ile Glu Cys Leu  Ser Ser Gly Ser Pro             
                2890                 2895                 2900            

gca cca agg aat tcc  tgg cag aaa gat gga  cag ccc ttg cta gaa         8974
Ala Pro Arg Asn Ser  Trp Gln Lys Asp Gly  Gln Pro Leu Leu Glu             
                2905                 2910                 2915            

gat gac cat cat aaa  ttt cta tct aat gga  cga att ctg cag att         9019
Asp Asp His His Lys  Phe Leu Ser Asn Gly  Arg Ile Leu Gln Ile             
                2920                 2925                 2930            

ctg aat act caa ata  aca gat atc ggc agg  tat gtg tgt gtt gct         9064
Leu Asn Thr Gln Ile  Thr Asp Ile Gly Arg  Tyr Val Cys Val Ala             
                2935                 2940                 2945            

gag aac aca gct ggg  agt gcc aaa aaa tat  ttt aac ctc aat gtt         9109
Glu Asn Thr Ala Gly  Ser Ala Lys Lys Tyr  Phe Asn Leu Asn Val             
                2950                 2955                 2960            

cat gtt cct cca agt  gtc att ggt cct aaa  tct gaa aat ctt acc         9154
His Val Pro Pro Ser  Val Ile Gly Pro Lys  Ser Glu Asn Leu Thr             
                2965                 2970                 2975            

gtc gtg gtg aac aat  ttc atc tct ttg acc  tgt gag gtc tct ggt         9199
Val Val Val Asn Asn  Phe Ile Ser Leu Thr  Cys Glu Val Ser Gly             
                2980                 2985                 2990            

ttt cca cct cct gac  ctc agc tgg ctc aag  aat gaa cag ccc atc         9244
Phe Pro Pro Pro Asp  Leu Ser Trp Leu Lys  Asn Glu Gln Pro Ile             
                2995                 3000                 3005            

aaa ctg aac aca aat  act ctc att gtg cct  ggt ggt cga act cta         9289
Lys Leu Asn Thr Asn  Thr Leu Ile Val Pro  Gly Gly Arg Thr Leu             
                3010                 3015                 3020            

cag att att cgg gcc  aag gta tca gat ggt  ggt gaa tac act tgt         9334
Gln Ile Ile Arg Ala  Lys Val Ser Asp Gly  Gly Glu Tyr Thr Cys             
                3025                 3030                 3035            

ata gct atc aat caa  gct ggc gaa agc aag  aaa aag ttt tcc ctg         9379
Ile Ala Ile Asn Gln  Ala Gly Glu Ser Lys  Lys Lys Phe Ser Leu             
                3040                 3045                 3050            

act gtt tat gtg ccc  cca agc att aaa gac  cat gac agt gaa tct         9424
Thr Val Tyr Val Pro  Pro Ser Ile Lys Asp  His Asp Ser Glu Ser             
                3055                 3060                 3065            

ctt tct gta gtt aat  gta aga gag gga act  tct gtg tct ttg gag         9469
Leu Ser Val Val Asn  Val Arg Glu Gly Thr  Ser Val Ser Leu Glu             
                3070                 3075                 3080            

tgt gag tcg aac gct  gtg cca cct cca gtc  atc act tgg tat aag         9514
Cys Glu Ser Asn Ala  Val Pro Pro Pro Val  Ile Thr Trp Tyr Lys             
                3085                 3090                 3095            

aat ggg cgg atg ata  aca gag tct act cat  gtg gag att tta gct         9559
Asn Gly Arg Met Ile  Thr Glu Ser Thr His  Val Glu Ile Leu Ala             
                3100                 3105                 3110            

gat gga caa atg cta  cac att aag aaa gct  gag gta tct gac aca         9604
Asp Gly Gln Met Leu  His Ile Lys Lys Ala  Glu Val Ser Asp Thr             
                3115                 3120                 3125            

ggc cag tat gta tgt  aga gct ata aat gta  gca gga cgg gat gat         9649
Gly Gln Tyr Val Cys  Arg Ala Ile Asn Val  Ala Gly Arg Asp Asp             
                3130                 3135                 3140            

aaa aat ttc cac ctc  aat gta tat gtg cca  ccc agt att gaa gga         9694
Lys Asn Phe His Leu  Asn Val Tyr Val Pro  Pro Ser Ile Glu Gly             
                3145                 3150                 3155            

cct gaa aga gaa gtg  att gtg gag acg atc  agc aat cct gtg aca         9739
Pro Glu Arg Glu Val  Ile Val Glu Thr Ile  Ser Asn Pro Val Thr             
                3160                 3165                 3170            

tta aca tgt gat gcc  act ggg atc cca cct  ccc acg ata gca tgg         9784
Leu Thr Cys Asp Ala  Thr Gly Ile Pro Pro  Pro Thr Ile Ala Trp             
                3175                 3180                 3185            

tta aag aac cac aag  cgc ata gaa aat tct  gac tca ctg gaa gtt         9829
Leu Lys Asn His Lys  Arg Ile Glu Asn Ser  Asp Ser Leu Glu Val             
                3190                 3195                 3200            

cgt att ttg tct gga  ggt agc aaa ctc cag  att gcc cgg tct cag         9874
Arg Ile Leu Ser Gly  Gly Ser Lys Leu Gln  Ile Ala Arg Ser Gln             
                3205                 3210                 3215            

cat tca gat agt gga  aac tat aca tgt att  gct tca aat atg gag         9919
His Ser Asp Ser Gly  Asn Tyr Thr Cys Ile  Ala Ser Asn Met Glu             
                3220                 3225                 3230            

gga aaa gcc cag aaa  tat tac ttt ctt tca  att caa gtt cct cca         9964
Gly Lys Ala Gln Lys  Tyr Tyr Phe Leu Ser  Ile Gln Val Pro Pro             
                3235                 3240                 3245            

agt gtt gct ggt gct  gaa att cca agt gat  gtc agt gtc ctt cta        10009
Ser Val Ala Gly Ala  Glu Ile Pro Ser Asp  Val Ser Val Leu Leu             
                3250                 3255                 3260            

gga gaa aat gtt gag  ctg gtc tgc aat gca  aat ggc att cct act        10054
Gly Glu Asn Val Glu  Leu Val Cys Asn Ala  Asn Gly Ile Pro Thr             
                3265                 3270                 3275            

cca ctt att caa tgg  ctt aaa gat gga aag  ccc ata gct agt ggt        10099
Pro Leu Ile Gln Trp  Leu Lys Asp Gly Lys  Pro Ile Ala Ser Gly             
                3280                 3285                 3290            

gaa aca gaa aga atc  cga gtg agt gca aat  ggc agc aca tta aac        10144
Glu Thr Glu Arg Ile  Arg Val Ser Ala Asn  Gly Ser Thr Leu Asn             
                3295                 3300                 3305            

att tat gga gct ctt  aca tct gac acg ggg  aaa tac aca tgt gtt        10189
Ile Tyr Gly Ala Leu  Thr Ser Asp Thr Gly  Lys Tyr Thr Cys Val             
                3310                 3315                 3320            

gct act aat ccc gct  gga gaa gaa gac cga  att ttt aac ttg aat        10234
Ala Thr Asn Pro Ala  Gly Glu Glu Asp Arg  Ile Phe Asn Leu Asn             
                3325                 3330                 3335            

gtc tat gtt aca cct  aca att agg ggt aat  aaa gat gaa gca gag        10279
Val Tyr Val Thr Pro  Thr Ile Arg Gly Asn  Lys Asp Glu Ala Glu             
                3340                 3345                 3350            

aaa cta atg act tta  gtg gat act tca ata  aat att gaa tgc aga        10324
Lys Leu Met Thr Leu  Val Asp Thr Ser Ile  Asn Ile Glu Cys Arg             
                3355                 3360                 3365            

gcc aca ggg acg cct  cca cca cag ata aac  tgg ctg aag aat gga        10369
Ala Thr Gly Thr Pro  Pro Pro Gln Ile Asn  Trp Leu Lys Asn Gly             
                3370                 3375                 3380            

ctt cct ctg cct ctc  tcc tcc cat atc cgg  tta ctg gca gca gga        10414
Leu Pro Leu Pro Leu  Ser Ser His Ile Arg  Leu Leu Ala Ala Gly             
                3385                 3390                 3395            

caa gtt atc agg att  gtg aga gct cag gtg  tct gat gtc gct gtg        10459
Gln Val Ile Arg Ile  Val Arg Ala Gln Val  Ser Asp Val Ala Val             
                3400                 3405                 3410            

tat act tgt gtg gcc  tcc aac aga gct ggg  gtg gat aat aag cat        10504
Tyr Thr Cys Val Ala  Ser Asn Arg Ala Gly  Val Asp Asn Lys His             
                3415                 3420                 3425            

tac aat ctt caa gtg  ttt gca cca cca aat  atg gac aat tca atg        10549
Tyr Asn Leu Gln Val  Phe Ala Pro Pro Asn  Met Asp Asn Ser Met             
                3430                 3435                 3440            

ggg aca gag gaa atc  aca gtt ctc aaa ggt  agt tcc acc tct atg        10594
Gly Thr Glu Glu Ile  Thr Val Leu Lys Gly  Ser Ser Thr Ser Met             
                3445                 3450                 3455            

gca tgc att act gat  gga acc cca gct ccc  agt atg gcc tgg ctt        10639
Ala Cys Ile Thr Asp  Gly Thr Pro Ala Pro  Ser Met Ala Trp Leu             
                3460                 3465                 3470            

aga gat ggc cag cct  ctg ggg ctt gat gcc  cat ctg aca gtc agc        10684
Arg Asp Gly Gln Pro  Leu Gly Leu Asp Ala  His Leu Thr Val Ser             
                3475                 3480                 3485            

acc cat gga atg gtc  ctg cag ctc ctc aaa  gca gag act gaa gat        10729
Thr His Gly Met Val  Leu Gln Leu Leu Lys  Ala Glu Thr Glu Asp             
                3490                 3495                 3500            

tcg gga aag tac acc  tgc att gcc tca aat  gaa gct gga gaa gtc        10774
Ser Gly Lys Tyr Thr  Cys Ile Ala Ser Asn  Glu Ala Gly Glu Val             
                3505                 3510                 3515            

agc aag cac ttt atc  ctc aag gtc cta gaa  cca cct cac att aat        10819
Ser Lys His Phe Ile  Leu Lys Val Leu Glu  Pro Pro His Ile Asn             
                3520                 3525                 3530            

gga tct gaa gaa cat  gaa gag ata tca gta  att gtt aat aac cca        10864
Gly Ser Glu Glu His  Glu Glu Ile Ser Val  Ile Val Asn Asn Pro             
                3535                 3540                 3545            

ctt gaa ctt acc tgc  att gct tct gga atc  cca gcc cct aaa atg        10909
Leu Glu Leu Thr Cys  Ile Ala Ser Gly Ile  Pro Ala Pro Lys Met             
                3550                 3555                 3560            

acc tgg atg aaa gat  ggc cgg ccc ctt cca  cag acg gat caa gtg        10954
Thr Trp Met Lys Asp  Gly Arg Pro Leu Pro  Gln Thr Asp Gln Val             
                3565                 3570                 3575            

caa act cta gga gga  gga gag gtt ctt cga  att tct act gct cag        10999
Gln Thr Leu Gly Gly  Gly Glu Val Leu Arg  Ile Ser Thr Ala Gln             
                3580                 3585                 3590            

gtg gag gat aca gga  aga tat aca tgt ctg  gca tcc agt cct gca        11044
Val Glu Asp Thr Gly  Arg Tyr Thr Cys Leu  Ala Ser Ser Pro Ala             
                3595                 3600                 3605            

gga gat gat gat aag  gaa tat cta gtg aga  gtg cat gta cct cct        11089
Gly Asp Asp Asp Lys  Glu Tyr Leu Val Arg  Val His Val Pro Pro             
                3610                 3615                 3620            

aat att gct gga act  gat gag ccc cgg gat  atc act gtg tta cgg        11134
Asn Ile Ala Gly Thr  Asp Glu Pro Arg Asp  Ile Thr Val Leu Arg             
                3625                 3630                 3635            

aac aga caa gtg aca  ttg gaa tgc aag tca  gat gca gtg ccc cca        11179
Asn Arg Gln Val Thr  Leu Glu Cys Lys Ser  Asp Ala Val Pro Pro             
                3640                 3645                 3650            

cct gta att act tgg  ctc aga aat gga gaa  cgg tta cag gca aca        11224
Pro Val Ile Thr Trp  Leu Arg Asn Gly Glu  Arg Leu Gln Ala Thr             
                3655                 3660                 3665            

cct cga gtg cga atc  cta tct gga ggg aga  tac ttg caa atc aac        11269
Pro Arg Val Arg Ile  Leu Ser Gly Gly Arg  Tyr Leu Gln Ile Asn             
                3670                 3675                 3680            

aat gct gac cta ggt  gat aca gcc aat tat  acc tgt gtt gcc agc        11314
Asn Ala Asp Leu Gly  Asp Thr Ala Asn Tyr  Thr Cys Val Ala Ser             
                3685                 3690                 3695            

aac att gca gga aag  act aca aga gaa ttt  att ctc act gta aat        11359
Asn Ile Ala Gly Lys  Thr Thr Arg Glu Phe  Ile Leu Thr Val Asn             
                3700                 3705                 3710            

gtt cct cca aac ata  aag ggg ggc ccc cag  agc ctt gta att ctt        11404
Val Pro Pro Asn Ile  Lys Gly Gly Pro Gln  Ser Leu Val Ile Leu             
                3715                 3720                 3725            

tta aat aag tca act  gta ttg gaa tgc atc  gct gaa ggt gtg cca        11449
Leu Asn Lys Ser Thr  Val Leu Glu Cys Ile  Ala Glu Gly Val Pro             
                3730                 3735                 3740            

act cca agg ata aca  tgg aga aag gat gga  gct gtt cta gct ggg        11494
Thr Pro Arg Ile Thr  Trp Arg Lys Asp Gly  Ala Val Leu Ala Gly             
                3745                 3750                 3755            

aat cat gca aga tat  tcc atc ttg gaa aat  gga ttc ctt cat att        11539
Asn His Ala Arg Tyr  Ser Ile Leu Glu Asn  Gly Phe Leu His Ile             
                3760                 3765                 3770            

caa tca gca cat gtc  act gac act gga cgg  tat ttg tgt atg gcc        11584
Gln Ser Ala His Val  Thr Asp Thr Gly Arg  Tyr Leu Cys Met Ala             
                3775                 3780                 3785            

acc aat gct gct gga  aca gat cgc agg cga  ata gat tta cag gtc        11629
Thr Asn Ala Ala Gly  Thr Asp Arg Arg Arg  Ile Asp Leu Gln Val             
                3790                 3795                 3800            

cat gtt cct cca tct  att gct ccg ggt cct  acc aac atg act gta        11674
His Val Pro Pro Ser  Ile Ala Pro Gly Pro  Thr Asn Met Thr Val             
                3805                 3810                 3815            

ata gta aat gtt caa  act act ctg gct tgt  gag gct act ggg ata        11719
Ile Val Asn Val Gln  Thr Thr Leu Ala Cys  Glu Ala Thr Gly Ile             
                3820                 3825                 3830            

cca aaa cca tca atc  aat tgg aga aaa aat  ggg cat ctt ctt aat        11764
Pro Lys Pro Ser Ile  Asn Trp Arg Lys Asn  Gly His Leu Leu Asn             
                3835                 3840                 3845            

gtg gat caa aat cag  aac tca tac agg ctc  ctt tct tca ggt tca        11809
Val Asp Gln Asn Gln  Asn Ser Tyr Arg Leu  Leu Ser Ser Gly Ser             
                3850                 3855                 3860            

cta gta att att tcc  cct tct gtg gat gac  act gca acc tat gaa        11854
Leu Val Ile Ile Ser  Pro Ser Val Asp Asp  Thr Ala Thr Tyr Glu             
                3865                 3870                 3875            

tgt act gtg aca aac  ggt gct gga gat gat  aaa aga act gtg gat        11899
Cys Thr Val Thr Asn  Gly Ala Gly Asp Asp  Lys Arg Thr Val Asp             
                3880                 3885                 3890            

ctc act gtc caa gtt  cca cct tcc ata gct  gat gag cct aca gat        11944
Leu Thr Val Gln Val  Pro Pro Ser Ile Ala  Asp Glu Pro Thr Asp             
                3895                 3900                 3905            

ttc cta gta acc aaa  cat gcc cca gca gta  att acc tgc act gct        11989
Phe Leu Val Thr Lys  His Ala Pro Ala Val  Ile Thr Cys Thr Ala             
                3910                 3915                 3920            

tcg gga gtt cca ttt  ccc tca att cac tgg  acc aaa aat ggt ata        12034
Ser Gly Val Pro Phe  Pro Ser Ile His Trp  Thr Lys Asn Gly Ile             
                3925                 3930                 3935            

aga ctg ctt ccc agg  gga gat ggc tat aga  att ctg tcc tca gga        12079
Arg Leu Leu Pro Arg  Gly Asp Gly Tyr Arg  Ile Leu Ser Ser Gly             
                3940                 3945                 3950            

gca att gaa ata ctt  gcc acc caa tta aac  cat gct gga aga tac        12124
Ala Ile Glu Ile Leu  Ala Thr Gln Leu Asn  His Ala Gly Arg Tyr             
                3955                 3960                 3965            

act tgt gtc gct agg  aat gcg gct ggc tct  gca cat cga cac gtg        12169
Thr Cys Val Ala Arg  Asn Ala Ala Gly Ser  Ala His Arg His Val             
                3970                 3975                 3980            

acc ctt cat gtt cat  gag cct cca gtc att  cag ccc caa cca agt        12214
Thr Leu His Val His  Glu Pro Pro Val Ile  Gln Pro Gln Pro Ser             
                3985                 3990                 3995            

gaa cta cac gtc att  ctg aac aat cct att  tta tta cca tgt gaa        12259
Glu Leu His Val Ile  Leu Asn Asn Pro Ile  Leu Leu Pro Cys Glu             
                4000                 4005                 4010            

gca aca ggg aca ccc  agt cct ttc att act  tgg caa aaa gaa ggc        12304
Ala Thr Gly Thr Pro  Ser Pro Phe Ile Thr  Trp Gln Lys Glu Gly             
                4015                 4020                 4025            

atc aat gtt aac act  tca ggc aga aac cat  gca gtt ctt cct agt        12349
Ile Asn Val Asn Thr  Ser Gly Arg Asn His  Ala Val Leu Pro Ser             
                4030                 4035                 4040            

ggc ggc tta cag atc  tcc aga gct gtc cga  gag gat gct ggc act        12394
Gly Gly Leu Gln Ile  Ser Arg Ala Val Arg  Glu Asp Ala Gly Thr             
                4045                 4050                 4055            

tac atg tgt gtg gcc  cag aac ccg gct ggt  aca gcc ttg ggc aaa        12439
Tyr Met Cys Val Ala  Gln Asn Pro Ala Gly  Thr Ala Leu Gly Lys             
                4060                 4065                 4070            

atc aag tta aat gtc  caa gtt cct cca gtc  att agc cct cat cta        12484
Ile Lys Leu Asn Val  Gln Val Pro Pro Val  Ile Ser Pro His Leu             
                4075                 4080                 4085            

aag gaa tat gtt att  gct gtg gac aag ccc  atc acg tta tcc tgt        12529
Lys Glu Tyr Val Ile  Ala Val Asp Lys Pro  Ile Thr Leu Ser Cys             
                4090                 4095                 4100            

gaa gca gat ggc ctc  cct ccg cct gac att  aca tgg cat aaa gat        12574
Glu Ala Asp Gly Leu  Pro Pro Pro Asp Ile  Thr Trp His Lys Asp             
                4105                 4110                 4115            

ggg cgt gca att gtg  gaa tct atc cgc cag  cgc gtc ctc agc tct        12619
Gly Arg Ala Ile Val  Glu Ser Ile Arg Gln  Arg Val Leu Ser Ser             
                4120                 4125                 4130            

ggc tct ctg caa ata  gca ttt gtc cag cct  ggt gat gct ggc cat        12664
Gly Ser Leu Gln Ile  Ala Phe Val Gln Pro  Gly Asp Ala Gly His             
                4135                 4140                 4145            

tac acg tgc atg gca  gcc aat gta gca gga  tca agc agc aca agc        12709
Tyr Thr Cys Met Ala  Ala Asn Val Ala Gly  Ser Ser Ser Thr Ser             
                4150                 4155                 4160            

acc aag ctc acc gtc  cat gta cca ccc agg  atc aga agt aca gaa        12754
Thr Lys Leu Thr Val  His Val Pro Pro Arg  Ile Arg Ser Thr Glu             
                4165                 4170                 4175            

gga cac tac acg gtc  aat gag aat tca caa  gcc att ctt cca tgc        12799
Gly His Tyr Thr Val  Asn Glu Asn Ser Gln  Ala Ile Leu Pro Cys             
                4180                 4185                 4190            

gta gct gat gga atc  ccc aca cca gca att  aac tgg aaa aaa gac        12844
Val Ala Asp Gly Ile  Pro Thr Pro Ala Ile  Asn Trp Lys Lys Asp             
                4195                 4200                 4205            

aat gtt ctt tta gct  aac ttg tta gga aaa  tac act gct gaa cca        12889
Asn Val Leu Leu Ala  Asn Leu Leu Gly Lys  Tyr Thr Ala Glu Pro             
                4210                 4215                 4220            

tat gga gaa ctc att  tta gaa aat gtt gtg  ctg gag gat tct ggc        12934
Tyr Gly Glu Leu Ile  Leu Glu Asn Val Val  Leu Glu Asp Ser Gly             
                4225                 4230                 4235            

ttc tat acc tgt gtt  gct aac aat gct gca  ggt gaa gat aca cac        12979
Phe Tyr Thr Cys Val  Ala Asn Asn Ala Ala  Gly Glu Asp Thr His             
                4240                 4245                 4250            

act gtc agc ctg act  gtg cat gtt ctc ccc  act ttt act gaa ctt        13024
Thr Val Ser Leu Thr  Val His Val Leu Pro  Thr Phe Thr Glu Leu             
                4255                 4260                 4265            

cct gga gac gtg tca  tta aat aaa gga gaa  cag cta cga tta agc        13069
Pro Gly Asp Val Ser  Leu Asn Lys Gly Glu  Gln Leu Arg Leu Ser             
                4270                 4275                 4280            

tgt aaa gct act ggt  att cca ttg ccc aaa  tta aca tgg acc ttc        13114
Cys Lys Ala Thr Gly  Ile Pro Leu Pro Lys  Leu Thr Trp Thr Phe             
                4285                 4290                 4295            

aat aac aat att att  cca gcc cac ttt gac  agt gtg aat gga cac        13159
Asn Asn Asn Ile Ile  Pro Ala His Phe Asp  Ser Val Asn Gly His             
                4300                 4305                 4310            

agt gaa ctt gtt att  gaa aga gtg tca aaa  gag gat tca ggt act        13204
Ser Glu Leu Val Ile  Glu Arg Val Ser Lys  Glu Asp Ser Gly Thr             
                4315                 4320                 4325            

tat gtg tgc acc gca  gag aac agc gtt ggc  ttt gtg aag gca att        13249
Tyr Val Cys Thr Ala  Glu Asn Ser Val Gly  Phe Val Lys Ala Ile             
                4330                 4335                 4340            

gga ttt gtt tat gtg  aaa gaa cct cca gtc  ttc aaa ggt gat tat        13294
Gly Phe Val Tyr Val  Lys Glu Pro Pro Val  Phe Lys Gly Asp Tyr             
                4345                 4350                 4355            

cct tct aac tgg att  gaa cca ctt ggt ggg  aat gca atc ctg aat        13339
Pro Ser Asn Trp Ile  Glu Pro Leu Gly Gly  Asn Ala Ile Leu Asn             
                4360                 4365                 4370            

tgt gag gtg aaa gga  gac ccc acc cca acc  atc cag tgg aac aga        13384
Cys Glu Val Lys Gly  Asp Pro Thr Pro Thr  Ile Gln Trp Asn Arg             
                4375                 4380                 4385            

aag gga gtg gat att  gaa att agc cac aga  atc cgg caa ctg ggc        13429
Lys Gly Val Asp Ile  Glu Ile Ser His Arg  Ile Arg Gln Leu Gly             
                4390                 4395                 4400            

aat ggc tcc ctg gcc  atc tat ggc act gtt  aat gaa gat gcc ggt        13474
Asn Gly Ser Leu Ala  Ile Tyr Gly Thr Val  Asn Glu Asp Ala Gly             
                4405                 4410                 4415            

gac tat aca tgt gta  gct acc aat gaa gct  ggg gtg gtg gag cgc        13519
Asp Tyr Thr Cys Val  Ala Thr Asn Glu Ala  Gly Val Val Glu Arg             
                4420                 4425                 4430            

agc atg agt ctg act  ctg caa agt cct cct  att atc act ctt gag        13564
Ser Met Ser Leu Thr  Leu Gln Ser Pro Pro  Ile Ile Thr Leu Glu             
                4435                 4440                 4445            

cca gtg gaa act gtt  att aat gct ggt ggc  aaa atc ata ttg aat        13609
Pro Val Glu Thr Val  Ile Asn Ala Gly Gly  Lys Ile Ile Leu Asn             
                4450                 4455                 4460            

tgt cag gca act gga  gag cct caa cca acc  att aca tgg tcc cgt        13654
Cys Gln Ala Thr Gly  Glu Pro Gln Pro Thr  Ile Thr Trp Ser Arg             
                4465                 4470                 4475            

caa ggg cac tct att  tcc tgg gat gac cgg  gtt aac gtg ttg tcc        13699
Gln Gly His Ser Ile  Ser Trp Asp Asp Arg  Val Asn Val Leu Ser             
                4480                 4485                 4490            

aac aac tca tta tat  att gct gat gct cag  aaa gaa gat acc tct        13744
Asn Asn Ser Leu Tyr  Ile Ala Asp Ala Gln  Lys Glu Asp Thr Ser             
                4495                 4500                 4505            

gaa ttt gaa tgt gtt  gct cga aac tta atg  ggt tct gtc ctt gtc        13789
Glu Phe Glu Cys Val  Ala Arg Asn Leu Met  Gly Ser Val Leu Val             
                4510                 4515                 4520            

aga gtg cca gtc ata  gtc cag gtt cat ggt  gga ttt tcc cag tgg        13834
Arg Val Pro Val Ile  Val Gln Val His Gly  Gly Phe Ser Gln Trp             
                4525                 4530                 4535            

tct gca tgg aga gcc  tgc agt gtc acc tgt  gga aaa ggc atc caa        13879
Ser Ala Trp Arg Ala  Cys Ser Val Thr Cys  Gly Lys Gly Ile Gln             
                4540                 4545                 4550            

aag agg agt cgt ctg  tgc aac cag ccc ctt  cca gcc aat ggt ggg        13924
Lys Arg Ser Arg Leu  Cys Asn Gln Pro Leu  Pro Ala Asn Gly Gly             
                4555                 4560                 4565            

aag ccc tgc caa ggt  tca gat ttg gaa atg  cga aac tgt caa aat        13969
Lys Pro Cys Gln Gly  Ser Asp Leu Glu Met  Arg Asn Cys Gln Asn             
                4570                 4575                 4580            

aag cct tgt cca gtg  gat ggt agc tgg tcg  gaa tgg agt ctt tgg        14014
Lys Pro Cys Pro Val  Asp Gly Ser Trp Ser  Glu Trp Ser Leu Trp             
                4585                 4590                 4595            

gaa gaa tgc aca agg  agc tgt gga cgc ggc  aac caa acc agg acc        14059
Glu Glu Cys Thr Arg  Ser Cys Gly Arg Gly  Asn Gln Thr Arg Thr             
                4600                 4605                 4610            

agg act tgc aat aat  cca tca gtt cag cat  ggt ggg cgg cca tgt        14104
Arg Thr Cys Asn Asn  Pro Ser Val Gln His  Gly Gly Arg Pro Cys             
                4615                 4620                 4625            

gaa ggg aat gct gtg  gaa ata att atg tgc  aac att agg cct tgc        14149
Glu Gly Asn Ala Val  Glu Ile Ile Met Cys  Asn Ile Arg Pro Cys             
                4630                 4635                 4640            

cca gtt cat gga gca  tgg agc gct tgg cag  cct tgg gga aca tgc        14194
Pro Val His Gly Ala  Trp Ser Ala Trp Gln  Pro Trp Gly Thr Cys             
                4645                 4650                 4655            

agc gaa agt tgt ggg  aaa ggt act cag aca  aga gca aga ctt tgt        14239
Ser Glu Ser Cys Gly  Lys Gly Thr Gln Thr  Arg Ala Arg Leu Cys             
                4660                 4665                 4670            

aat aac cca cca cca  gcg ttt ggt ggg tcc  tac tgt gat gga gca        14284
Asn Asn Pro Pro Pro  Ala Phe Gly Gly Ser  Tyr Cys Asp Gly Ala             
                4675                 4680                 4685            

gaa aca cag atg caa  gtt tgc aat gaa aga  aat tgt cca att cat        14329
Glu Thr Gln Met Gln  Val Cys Asn Glu Arg  Asn Cys Pro Ile His             
                4690                 4695                 4700            

ggc aag tgg gcg act  tgg gcc agt tgg agt  gcc tgt tct gtg tca        14374
Gly Lys Trp Ala Thr  Trp Ala Ser Trp Ser  Ala Cys Ser Val Ser             
                4705                 4710                 4715            

tgt gga gga ggt gcc  aga cag aga aca agg  ggc tgc tcc gac cct        14419
Cys Gly Gly Gly Ala  Arg Gln Arg Thr Arg  Gly Cys Ser Asp Pro             
                4720                 4725                 4730            

gtg ccc cag tat gga  gga agg aaa tgc gaa  ggg agt gat gtc cag        14464
Val Pro Gln Tyr Gly  Gly Arg Lys Cys Glu  Gly Ser Asp Val Gln             
                4735                 4740                 4745            

agt gat ttt tgc aac  agt gac cct tgc cca  acc cat ggt aac tgg        14509
Ser Asp Phe Cys Asn  Ser Asp Pro Cys Pro  Thr His Gly Asn Trp             
                4750                 4755                 4760            

agt cct tgg agt ggc  tgg gga aca tgc agc  cgg acg tgt aac gga        14554
Ser Pro Trp Ser Gly  Trp Gly Thr Cys Ser  Arg Thr Cys Asn Gly             
                4765                 4770                 4775            

ggg cag atg cgg cgg  tac cgc aca tgt gat  aac cct cct ccc tcc        14599
Gly Gln Met Arg Arg  Tyr Arg Thr Cys Asp  Asn Pro Pro Pro Ser             
                4780                 4785                 4790            

aat ggg gga aga gct  tgt ggg gga cca gac  tcc cag atc cag agg        14644
Asn Gly Gly Arg Ala  Cys Gly Gly Pro Asp  Ser Gln Ile Gln Arg             
                4795                 4800                 4805            

tgc aac act gac atg  tgt cct gtg gat gga  agt tgg gga agc tgg        14689
Cys Asn Thr Asp Met  Cys Pro Val Asp Gly  Ser Trp Gly Ser Trp             
                4810                 4815                 4820            

cat agt tgg agc cag  tgc tct gcc tcc tgt  gga gga ggt gaa aag        14734
His Ser Trp Ser Gln  Cys Ser Ala Ser Cys  Gly Gly Gly Glu Lys             
                4825                 4830                 4835            

act cgg aag cgg ctg  tgc gac cat cct gtg  cca gtt aaa ggt ggc        14779
Thr Arg Lys Arg Leu  Cys Asp His Pro Val  Pro Val Lys Gly Gly             
                4840                 4845                 4850            

cgt ccc tgt ccc gga  gac act act cag gtg  acc agg tgc aat gta        14824
Arg Pro Cys Pro Gly  Asp Thr Thr Gln Val  Thr Arg Cys Asn Val             
                4855                 4860                 4865            

caa gca tgt cca ggt  ggg ccc cag cga gcc  aga gga agt gtt att        14869
Gln Ala Cys Pro Gly  Gly Pro Gln Arg Ala  Arg Gly Ser Val Ile             
                4870                 4875                 4880            

gga aat att aat gat  gtt gaa ttt gga att  gct ttc ctt aat gcc        14914
Gly Asn Ile Asn Asp  Val Glu Phe Gly Ile  Ala Phe Leu Asn Ala             
                4885                 4890                 4895            

aca ata act gat agc  cct aac tct gat act  aga ata ata cgt gcc        14959
Thr Ile Thr Asp Ser  Pro Asn Ser Asp Thr  Arg Ile Ile Arg Ala             
                4900                 4905                 4910            

aaa att acc aat gta  cct cgt agt ctt ggt  tca gca atg aga aag        15004
Lys Ile Thr Asn Val  Pro Arg Ser Leu Gly  Ser Ala Met Arg Lys             
                4915                 4920                 4925            

ata gtt tct att cta  aat ccc att tat tgg  aca aca gca aag gaa        15049
Ile Val Ser Ile Leu  Asn Pro Ile Tyr Trp  Thr Thr Ala Lys Glu             
                4930                 4935                 4940            

ata gga gaa gca gtc  aat ggc ttt acc ctc  acc aat gca gtc ttc        15094
Ile Gly Glu Ala Val  Asn Gly Phe Thr Leu  Thr Asn Ala Val Phe             
                4945                 4950                 4955            

aaa aga gaa act caa  gtg gaa ttt gca act  gga gaa atc ttg cag        15139
Lys Arg Glu Thr Gln  Val Glu Phe Ala Thr  Gly Glu Ile Leu Gln             
                4960                 4965                 4970            

atg agt cat att gcc  cgg ggc ttg gat tcc  gat ggt tct ttg ctg        15184
Met Ser His Ile Ala  Arg Gly Leu Asp Ser  Asp Gly Ser Leu Leu             
                4975                 4980                 4985            

cta gat atc gtt gtg  agt ggc tat gtc cta  cag ctt cag tca cct        15229
Leu Asp Ile Val Val  Ser Gly Tyr Val Leu  Gln Leu Gln Ser Pro             
                4990                 4995                 5000            

gct gaa gtc act gta  aag gat tac aca gag  gac tac att caa aca        15274
Ala Glu Val Thr Val  Lys Asp Tyr Thr Glu  Asp Tyr Ile Gln Thr             
                5005                 5010                 5015            

ggt cct ggg cag ctg  tac gcc tac tca acc  cgg ctg ttc acc att        15319
Gly Pro Gly Gln Leu  Tyr Ala Tyr Ser Thr  Arg Leu Phe Thr Ile             
                5020                 5025                 5030            

gat ggc atc agc atc  cca tac aca tgg aac  cac acc gtt ttc tat        15364
Asp Gly Ile Ser Ile  Pro Tyr Thr Trp Asn  His Thr Val Phe Tyr             
                5035                 5040                 5045            

gat cag gca cag gga  aga atg cct ttc ttg  gtt gaa aca ctt cat        15409
Asp Gln Ala Gln Gly  Arg Met Pro Phe Leu  Val Glu Thr Leu His             
                5050                 5055                 5060            

gca tcc tct gtg gaa  tct gac tat aac cag  ata gaa gag aca ctg        15454
Ala Ser Ser Val Glu  Ser Asp Tyr Asn Gln  Ile Glu Glu Thr Leu             
                5065                 5070                 5075            

ggt ttt aaa att cat  gct tca ata tcc aaa  gga gat cgc agt aat        15499
Gly Phe Lys Ile His  Ala Ser Ile Ser Lys  Gly Asp Arg Ser Asn             
                5080                 5085                 5090            

cag tgc ccc tcc ggg  ttt acc tta gac tca  gtt gga cct ttt tgt        15544
Gln Cys Pro Ser Gly  Phe Thr Leu Asp Ser  Val Gly Pro Phe Cys             
                5095                 5100                 5105            

gct gat gag gat gaa  tgt gca gca ggg aat  ccc tgc tcc cat agc        15589
Ala Asp Glu Asp Glu  Cys Ala Ala Gly Asn  Pro Cys Ser His Ser             
                5110                 5115                 5120            

tgc cac aat gcc atg  ggg act tac tac tgc  tcc tgc cct aaa ggc        15634
Cys His Asn Ala Met  Gly Thr Tyr Tyr Cys  Ser Cys Pro Lys Gly             
                5125                 5130                 5135            

ctc acc ata gct gca  gat gga aga act tgt  caa gat att gat gag        15679
Leu Thr Ile Ala Ala  Asp Gly Arg Thr Cys  Gln Asp Ile Asp Glu             
                5140                 5145                 5150            

tgt gct ttg ggt agg  cat acc tgc cac gct  ggt cag gac tgt gac        15724
Cys Ala Leu Gly Arg  His Thr Cys His Ala  Gly Gln Asp Cys Asp             
                5155                 5160                 5165            

aat acg att gga tct  tat cgc tgt gtg gtc  cgt tgt gga agt ggc        15769
Asn Thr Ile Gly Ser  Tyr Arg Cys Val Val  Arg Cys Gly Ser Gly             
                5170                 5175                 5180            

ttt cga aga acc tct  gat ggg ctg agt tgt  caa gat att aat gaa        15814
Phe Arg Arg Thr Ser  Asp Gly Leu Ser Cys  Gln Asp Ile Asn Glu             
                5185                 5190                 5195            

tgt caa gaa tcc agc  ccc tgt cac cag cgc  tgt ttc aat gcc ata        15859
Cys Gln Glu Ser Ser  Pro Cys His Gln Arg  Cys Phe Asn Ala Ile             
                5200                 5205                 5210            

gga agt ttc cat tgt  gga tgt gaa cct ggg  tat cag ctc aaa ggc        15904
Gly Ser Phe His Cys  Gly Cys Glu Pro Gly  Tyr Gln Leu Lys Gly             
                5215                 5220                 5225            

aga aaa tgc atg gat  gtg aac gag tgt aga  caa aat gta tgc aga        15949
Arg Lys Cys Met Asp  Val Asn Glu Cys Arg  Gln Asn Val Cys Arg             
                5230                 5235                 5240            

cca gat cag cac tgt  aag aac acc cgt ggt  ggc tat aag tgc att        15994
Pro Asp Gln His Cys  Lys Asn Thr Arg Gly  Gly Tyr Lys Cys Ile             
                5245                 5250                 5255            

gat ctt tgt cca aat  gga atg acc aag gca  gaa aat gga acc tgt        16039
Asp Leu Cys Pro Asn  Gly Met Thr Lys Ala  Glu Asn Gly Thr Cys             
                5260                 5265                 5270            

att gat att gat gaa  tgt aaa gat ggg acc  cat cag tgc aga tat        16084
Ile Asp Ile Asp Glu  Cys Lys Asp Gly Thr  His Gln Cys Arg Tyr             
                5275                 5280                 5285            

aac cag ata tgt gag  aat aca aga ggc agc  tat cgt tgt gta tgc        16129
Asn Gln Ile Cys Glu  Asn Thr Arg Gly Ser  Tyr Arg Cys Val Cys             
                5290                 5295                 5300            

cca aga ggt tat cgg  tct caa gga gtt gga  aga ccc tgc atg gac        16174
Pro Arg Gly Tyr Arg  Ser Gln Gly Val Gly  Arg Pro Cys Met Asp             
                5305                 5310                 5315            

att aat gaa tgt gaa  caa gtg cct aaa cct  tgt gca cat cag tgc        16219
Ile Asn Glu Cys Glu  Gln Val Pro Lys Pro  Cys Ala His Gln Cys             
                5320                 5325                 5330            

tcc aac acc ccc ggc  agc ttc aag tgt atc  tgt cca cca gga caa        16264
Ser Asn Thr Pro Gly  Ser Phe Lys Cys Ile  Cys Pro Pro Gly Gln             
                5335                 5340                 5345            

cat tta tta ggg gac  ggg aaa tct tgc gct  gga ttg gag agg ctg        16309
His Leu Leu Gly Asp  Gly Lys Ser Cys Ala  Gly Leu Glu Arg Leu             
                5350                 5355                 5360            

cca aat tat ggc act  caa tac agt agc tat  aac ctt gca cgg ttc        16354
Pro Asn Tyr Gly Thr  Gln Tyr Ser Ser Tyr  Asn Leu Ala Arg Phe             
                5365                 5370                 5375            

tcc cct gtg aga aac  aac tat caa cct caa  cag cat tac aga cag        16399
Ser Pro Val Arg Asn  Asn Tyr Gln Pro Gln  Gln His Tyr Arg Gln             
                5380                 5385                 5390            

tac tca cat ctc tac  agc tcc tac tca gag  tat aga aac agc aga        16444
Tyr Ser His Leu Tyr  Ser Ser Tyr Ser Glu  Tyr Arg Asn Ser Arg             
                5395                 5400                 5405            

aca tct ctc tcc agg  act aga agg act att  agg aaa act tgc cct        16489
Thr Ser Leu Ser Arg  Thr Arg Arg Thr Ile  Arg Lys Thr Cys Pro             
                5410                 5415                 5420            

gaa ggc tct gag gca  agc cat gac aca tgt  gta gat att gat gaa        16534
Glu Gly Ser Glu Ala  Ser His Asp Thr Cys  Val Asp Ile Asp Glu             
                5425                 5430                 5435            

tgt gaa aat aca gat  gcc tgc cag cat gag  tgt aag aat acc ttt        16579
Cys Glu Asn Thr Asp  Ala Cys Gln His Glu  Cys Lys Asn Thr Phe             
                5440                 5445                 5450            

gga agt tat cag tgc  atc tgc cca cct ggc  tat caa ctc aca cac        16624
Gly Ser Tyr Gln Cys  Ile Cys Pro Pro Gly  Tyr Gln Leu Thr His             
                5455                 5460                 5465            

aat gga aag aca tgc  caa gat atc gat gaa  tgt ctg gag cag aat        16669
Asn Gly Lys Thr Cys  Gln Asp Ile Asp Glu  Cys Leu Glu Gln Asn             
                5470                 5475                 5480            

gtg cac tgt gga ccc  aat cgc atg tgc ttc  aac atg aga gga agc        16714
Val His Cys Gly Pro  Asn Arg Met Cys Phe  Asn Met Arg Gly Ser             
                5485                 5490                 5495            

tac cag tgc atc gat  aca ccc tgt cca ccc  aac tac caa cgg gat        16759
Tyr Gln Cys Ile Asp  Thr Pro Cys Pro Pro  Asn Tyr Gln Arg Asp             
                5500                 5505                 5510            

cct gtt tca ggg ttc  tgc ctc aag aac tgt  cca ccc aat gat ttg        16804
Pro Val Ser Gly Phe  Cys Leu Lys Asn Cys  Pro Pro Asn Asp Leu             
                5515                 5520                 5525            

gaa tgt gcc ttg agc  cca tat gcc ttg gaa  tac aaa ctc gtc tcc        16849
Glu Cys Ala Leu Ser  Pro Tyr Ala Leu Glu  Tyr Lys Leu Val Ser             
                5530                 5535                 5540            

ctc cca ttt gga ata  gcc acc aat caa gat  tta atc cgg ctg gtt        16894
Leu Pro Phe Gly Ile  Ala Thr Asn Gln Asp  Leu Ile Arg Leu Val             
                5545                 5550                 5555            

gca tac aca cag gat  gga gtg atg cat ccc  agg aca act ttc ctc        16939
Ala Tyr Thr Gln Asp  Gly Val Met His Pro  Arg Thr Thr Phe Leu             
                5560                 5565                 5570            

atg gta gat gag gaa  cag act gtt cct ttt  gcc ttg agg gat gaa        16984
Met Val Asp Glu Glu  Gln Thr Val Pro Phe  Ala Leu Arg Asp Glu             
                5575                 5580                 5585            

aac ctg aaa gga gtg  gtg tat aca aca cga  cca cta cga gaa gca        17029
Asn Leu Lys Gly Val  Val Tyr Thr Thr Arg  Pro Leu Arg Glu Ala             
                5590                 5595                 5600            

gag acc tac cgc atg  agg gtc cga gcc tca  tcc tac agt gcc aat        17074
Glu Thr Tyr Arg Met  Arg Val Arg Ala Ser  Ser Tyr Ser Ala Asn             
                5605                 5610                 5615            

ggg acc att gaa tat  cag acc aca ttc ata  gtt tat ata gct gtg        17119
Gly Thr Ile Glu Tyr  Gln Thr Thr Phe Ile  Val Tyr Ile Ala Val             
                5620                 5625                 5630            

tcc gcc tat cca tac  taa ggaactctcc aaagcctatt ccacatattt            17167
Ser Ala Tyr Pro Tyr                                                       
                5635                                                      

aaaccgcatt aatcatggca atcaagcccc cttccagatt actgtctctt gaacagttgc    17227

aatcttggca gcttgaaaat ggtgctacac tctgttttgt gtgccttcct tggtacttct    17287

gaggtatttt catgatccca ccatggtcat atcttgaagt atggtctaga aaagtccctt    17347

attattttat ttattacact ggagcagtta cttcccaaag attattctga acatctaaca    17407

ggacatatca gtgatggttt acagtagtgt agtacctaag atcattttcc tgaaagccaa    17467

accaaacaac gaaaaacaag aacaactaat tcagaatcaa atagagtttt tgagcatttg    17527

actattttta gaatcataaa attagttact aagtattttg atcaaagctt ataaaataac    17587

ttacggagat ttttgtaagt attgatacat tataatagga cttgcctatt ttcattttta    17647

agaagaaaaa caccactcat tttataaaat atagtacagc tactataagg cttgtttgat    17707

cccaaatggt gcttatcttg attgaacatt cagaacaagg atattatttt cagtgatttt    17767

gtgagatcag ctgaaccact tatgataata ataataaaaa agactgcttt gccctcacgt    17827

cagttgtaca tggcatggaa ctttaaaaat tttaatataa actttcatcc agttagcttc    17887

ataactttta cgttccagaa ttttgtttat tttcctgtca atgaaagcaa tttttaaaga    17947

taccagtggg acaggtttgg ttttttaaaa atctcatgtg ttcaaattaa cataaatatt    18007

acacgtcaat acactgtaca tggtggtaat agactctaag caattgccaa gatgtattct    18067

atttttatga agtgtatata tattacctta gtgtgcattt tctatataat atcttgatgg    18127

actcttttat aaaattattt tataaaaaac aatgttacac taaaatcagc ctaaataaat    18187

tttcacaact ttttttcata acctt                                          18212


<210>  168
<211>  5635
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Ile Ser Trp Glu Val Val His Thr Val Phe Leu Phe Ala Leu Leu 
1               5                   10                  15      


Tyr Ser Ser Leu Ala Gln Asp Ala Ser Pro Gln Ser Glu Ile Arg Ala 
            20                  25                  30          


Glu Glu Ile Pro Glu Gly Ala Ser Thr Leu Ala Phe Val Phe Asp Val 
        35                  40                  45              


Thr Gly Ser Met Tyr Asp Asp Leu Val Gln Val Ile Glu Gly Ala Ser 
    50                  55                  60                  


Lys Ile Leu Glu Thr Ser Leu Lys Arg Pro Lys Arg Pro Leu Phe Asn 
65                  70                  75                  80  


Phe Ala Leu Val Pro Phe His Asp Pro Glu Ile Gly Pro Val Thr Ile 
                85                  90                  95      


Thr Thr Asp Pro Lys Lys Phe Gln Tyr Glu Leu Arg Glu Leu Tyr Val 
            100                 105                 110         


Gln Gly Gly Gly Asp Cys Pro Glu Met Ser Ile Gly Ala Ile Lys Ile 
        115                 120                 125             


Ala Leu Glu Ile Ser Leu Pro Gly Ser Phe Ile Tyr Val Phe Thr Asp 
    130                 135                 140                 


Ala Arg Ser Lys Asp Tyr Arg Leu Thr His Glu Val Leu Gln Leu Ile 
145                 150                 155                 160 


Gln Gln Lys Gln Ser Gln Val Val Phe Val Leu Thr Gly Asp Cys Asp 
                165                 170                 175     


Asp Arg Thr His Ile Gly Tyr Lys Val Tyr Glu Glu Ile Ala Ser Thr 
            180                 185                 190         


Ser Ser Gly Gln Val Phe His Leu Asp Lys Lys Gln Val Asn Glu Val 
        195                 200                 205             


Leu Lys Trp Val Glu Glu Ala Val Gln Ala Ser Lys Val His Leu Leu 
    210                 215                 220                 


Ser Thr Asp His Leu Glu Gln Ala Val Asn Thr Trp Arg Ile Pro Phe 
225                 230                 235                 240 


Asp Pro Ser Leu Lys Glu Val Thr Val Ser Leu Ser Gly Pro Ser Pro 
                245                 250                 255     


Met Ile Glu Ile Arg Asn Pro Leu Gly Lys Leu Ile Lys Lys Gly Phe 
            260                 265                 270         


Gly Leu His Glu Leu Leu Asn Ile His Asn Ser Ala Lys Val Val Asn 
        275                 280                 285             


Val Lys Glu Pro Glu Ala Gly Met Trp Thr Val Lys Thr Ser Ser Ser 
    290                 295                 300                 


Gly Arg His Ser Val Arg Ile Thr Gly Leu Ser Thr Ile Asp Phe Arg 
305                 310                 315                 320 


Ala Gly Phe Ser Arg Lys Pro Thr Leu Asp Phe Lys Lys Thr Val Ser 
                325                 330                 335     


Arg Pro Val Gln Gly Ile Pro Thr Tyr Val Leu Leu Asn Thr Ser Gly 
            340                 345                 350         


Ile Ser Thr Pro Ala Arg Ile Asp Leu Leu Glu Leu Leu Ser Ile Ser 
        355                 360                 365             


Gly Ser Ser Leu Lys Thr Ile Pro Val Lys Tyr Tyr Pro His Arg Lys 
    370                 375                 380                 


Pro Tyr Gly Ile Trp Asn Ile Ser Asp Phe Val Pro Pro Asn Glu Ala 
385                 390                 395                 400 


Phe Phe Leu Lys Val Thr Gly Tyr Asp Lys Asp Asp Tyr Leu Phe Gln 
                405                 410                 415     


Arg Val Ser Ser Val Ser Phe Ser Ser Ile Val Pro Asp Ala Pro Lys 
            420                 425                 430         


Val Thr Met Pro Glu Lys Thr Pro Gly Tyr Tyr Leu Gln Pro Gly Gln 
        435                 440                 445             


Ile Pro Cys Ser Val Asp Ser Leu Leu Pro Phe Thr Leu Ser Phe Val 
    450                 455                 460                 


Arg Asn Gly Val Thr Leu Gly Val Asp Gln Tyr Leu Lys Glu Ser Ala 
465                 470                 475                 480 


Ser Val Asn Leu Asp Ile Ala Lys Val Thr Leu Ser Asp Glu Gly Phe 
                485                 490                 495     


Tyr Glu Cys Ile Ala Val Ser Ser Ala Gly Thr Gly Arg Ala Gln Thr 
            500                 505                 510         


Phe Phe Asp Val Ser Glu Pro Pro Pro Val Ile Gln Val Pro Asn Asn 
        515                 520                 525             


Val Thr Val Thr Pro Gly Glu Arg Ala Val Leu Thr Cys Leu Ile Ile 
    530                 535                 540                 


Ser Ala Val Asp Tyr Asn Leu Thr Trp Gln Arg Asn Asp Arg Asp Val 
545                 550                 555                 560 


Arg Leu Ala Glu Pro Ala Arg Ile Arg Thr Leu Ala Asn Leu Ser Leu 
                565                 570                 575     


Glu Leu Lys Ser Val Lys Phe Asn Asp Ala Gly Glu Tyr His Cys Met 
            580                 585                 590         


Val Ser Ser Glu Gly Gly Ser Ser Ala Ala Ser Val Phe Leu Thr Val 
        595                 600                 605             


Gln Glu Pro Pro Lys Val Thr Val Met Pro Lys Asn Gln Ser Phe Thr 
    610                 615                 620                 


Gly Gly Ser Glu Val Ser Ile Met Cys Ser Ala Thr Gly Tyr Pro Lys 
625                 630                 635                 640 


Pro Lys Ile Ala Trp Thr Val Asn Asp Met Phe Ile Val Gly Ser His 
                645                 650                 655     


Arg Tyr Arg Met Thr Ser Asp Gly Thr Leu Phe Ile Lys Asn Ala Ala 
            660                 665                 670         


Pro Lys Asp Ala Gly Ile Tyr Gly Cys Leu Ala Ser Asn Ser Ala Gly 
        675                 680                 685             


Thr Asp Lys Gln Asn Ser Thr Leu Arg Tyr Ile Glu Ala Pro Lys Leu 
    690                 695                 700                 


Met Val Val Gln Ser Glu Leu Leu Val Ala Leu Gly Asp Ile Thr Val 
705                 710                 715                 720 


Met Glu Cys Lys Thr Ser Gly Ile Pro Pro Pro Gln Val Lys Trp Phe 
                725                 730                 735     


Lys Gly Asp Leu Glu Leu Arg Pro Ser Thr Phe Leu Ile Ile Asp Pro 
            740                 745                 750         


Leu Leu Gly Leu Leu Lys Ile Gln Glu Thr Gln Asp Leu Asp Ala Gly 
        755                 760                 765             


Asp Tyr Thr Cys Val Ala Ile Asn Glu Ala Gly Arg Ala Thr Gly Lys 
    770                 775                 780                 


Ile Thr Leu Asp Val Gly Ser Pro Pro Val Phe Ile Gln Glu Pro Ala 
785                 790                 795                 800 


Asp Val Ser Met Glu Ile Gly Ser Asn Val Thr Leu Pro Cys Tyr Val 
                805                 810                 815     


Gln Gly Tyr Pro Glu Pro Thr Ile Lys Trp Arg Arg Leu Asp Asn Met 
            820                 825                 830         


Pro Ile Phe Ser Arg Pro Phe Ser Val Ser Ser Ile Ser Gln Leu Arg 
        835                 840                 845             


Thr Gly Ala Leu Phe Ile Leu Asn Leu Trp Ala Ser Asp Lys Gly Thr 
    850                 855                 860                 


Tyr Ile Cys Glu Ala Glu Asn Gln Phe Gly Lys Ile Gln Ser Glu Thr 
865                 870                 875                 880 


Thr Val Thr Val Thr Gly Leu Val Ala Pro Leu Ile Gly Ile Ser Pro 
                885                 890                 895     


Ser Val Ala Asn Val Ile Glu Gly Gln Gln Leu Thr Leu Pro Cys Thr 
            900                 905                 910         


Leu Leu Ala Gly Asn Pro Ile Pro Glu Arg Arg Trp Ile Lys Asn Ser 
        915                 920                 925             


Ala Met Leu Leu Gln Asn Pro Tyr Ile Thr Val Arg Ser Asp Gly Ser 
    930                 935                 940                 


Leu His Ile Glu Arg Val Gln Leu Gln Asp Gly Gly Glu Tyr Thr Cys 
945                 950                 955                 960 


Val Ala Ser Asn Val Ala Gly Thr Asn Asn Lys Thr Thr Ser Val Val 
                965                 970                 975     


Val His Val Leu Pro Thr Ile Gln His Gly Gln Gln Ile Leu Ser Thr 
            980                 985                 990         


Ile Glu Gly Ile Pro Val Thr Leu  Pro Cys Lys Ala Ser  Gly Asn Pro 
        995                 1000                 1005             


Lys Pro  Ser Val Ile Trp Ser  Lys Lys Gly Glu Leu  Ile Ser Thr 
    1010                 1015                 1020             


Ser Ser  Ala Lys Phe Ser Ala  Gly Ala Asp Gly Ser  Leu Tyr Val 
    1025                 1030                 1035             


Val Ser  Pro Gly Gly Glu Glu  Ser Gly Glu Tyr Val  Cys Thr Ala 
    1040                 1045                 1050             


Thr Asn  Thr Ala Gly Tyr Ala  Lys Arg Lys Val Gln  Leu Thr Val 
    1055                 1060                 1065             


Tyr Val  Arg Pro Arg Val Phe  Gly Asp Gln Arg Gly  Leu Ser Gln 
    1070                 1075                 1080             


Asp Lys  Pro Val Glu Ile Ser  Val Leu Ala Gly Glu  Glu Val Thr 
    1085                 1090                 1095             


Leu Pro  Cys Glu Val Lys Ser  Leu Pro Pro Pro Ile  Ile Thr Trp 
    1100                 1105                 1110             


Ala Lys  Glu Thr Gln Leu Ile  Ser Pro Phe Ser Pro  Arg His Thr 
    1115                 1120                 1125             


Phe Leu  Pro Ser Gly Ser Met  Lys Ile Thr Glu Thr  Arg Thr Ser 
    1130                 1135                 1140             


Asp Ser  Gly Met Tyr Leu Cys  Val Ala Thr Asn Ile  Ala Gly Asn 
    1145                 1150                 1155             


Val Thr  Gln Ala Val Lys Leu  Asn Val His Val Pro  Pro Lys Ile 
    1160                 1165                 1170             


Gln Arg  Gly Pro Lys His Leu  Lys Val Gln Val Gly  Gln Arg Val 
    1175                 1180                 1185             


Asp Ile  Pro Cys Asn Ala Gln  Gly Thr Pro Leu Pro  Val Ile Thr 
    1190                 1195                 1200             


Trp Ser  Lys Gly Gly Ser Thr  Met Leu Val Asp Gly  Glu His His 
    1205                 1210                 1215             


Val Ser  Asn Pro Asp Gly Thr  Leu Ser Ile Asp Gln  Ala Thr Pro 
    1220                 1225                 1230             


Ser Asp  Ala Gly Ile Tyr Thr  Cys Val Ala Thr Asn  Ile Ala Gly 
    1235                 1240                 1245             


Thr Asp  Glu Thr Glu Ile Thr  Leu His Val Gln Glu  Pro Pro Thr 
    1250                 1255                 1260             


Val Glu  Asp Leu Glu Pro Pro  Tyr Asn Thr Thr Phe  Gln Glu Arg 
    1265                 1270                 1275             


Val Ala  Asn Gln Arg Ile Glu  Phe Pro Cys Pro Ala  Lys Gly Thr 
    1280                 1285                 1290             


Pro Lys  Pro Thr Ile Lys Trp  Leu His Asn Gly Arg  Glu Leu Thr 
    1295                 1300                 1305             


Gly Arg  Glu Pro Gly Ile Ser  Ile Leu Glu Asp Gly  Thr Leu Leu 
    1310                 1315                 1320             


Val Ile  Ala Ser Val Thr Pro  Tyr Asp Asn Gly Glu  Tyr Ile Cys 
    1325                 1330                 1335             


Val Ala  Val Asn Glu Ala Gly  Thr Thr Glu Arg Lys  Tyr Asn Leu 
    1340                 1345                 1350             


Lys Val  His Val Pro Pro Val  Ile Lys Asp Lys Glu  Gln Val Thr 
    1355                 1360                 1365             


Asn Val  Ser Val Leu Leu Asn  Gln Leu Thr Asn Leu  Phe Cys Glu 
    1370                 1375                 1380             


Val Glu  Gly Thr Pro Ser Pro  Ile Ile Met Trp Tyr  Lys Asp Asn 
    1385                 1390                 1395             


Val Gln  Val Thr Glu Ser Ser  Thr Ile Gln Thr Val  Asn Asn Gly 
    1400                 1405                 1410             


Lys Ile  Leu Lys Leu Phe Arg  Ala Thr Pro Glu Asp  Ala Gly Arg 
    1415                 1420                 1425             


Tyr Ser  Cys Lys Ala Ile Asn  Ile Ala Gly Thr Ser  Gln Lys Tyr 
    1430                 1435                 1440             


Phe Asn  Ile Asp Val Leu Val  Pro Pro Thr Ile Ile  Gly Thr Asn 
    1445                 1450                 1455             


Phe Pro  Asn Glu Val Ser Val  Val Leu Asn Arg Asp  Val Ala Leu 
    1460                 1465                 1470             


Glu Cys  Gln Val Lys Gly Thr  Pro Phe Pro Asp Ile  His Trp Phe 
    1475                 1480                 1485             


Lys Asp  Gly Lys Pro Leu Phe  Leu Gly Asp Pro Asn  Val Glu Leu 
    1490                 1495                 1500             


Leu Asp  Arg Gly Gln Val Leu  His Leu Lys Asn Ala  Arg Arg Asn 
    1505                 1510                 1515             


Asp Lys  Gly Arg Tyr Gln Cys  Thr Val Ser Asn Ala  Ala Gly Lys 
    1520                 1525                 1530             


Gln Ala  Lys Asp Ile Lys Leu  Thr Ile Tyr Ile Pro  Pro Ser Ile 
    1535                 1540                 1545             


Lys Gly  Gly Asn Val Thr Thr  Asp Ile Ser Val Leu  Ile Asn Ser 
    1550                 1555                 1560             


Leu Ile  Lys Leu Glu Cys Glu  Thr Arg Gly Leu Pro  Met Pro Ala 
    1565                 1570                 1575             


Ile Thr  Trp Tyr Lys Asp Gly  Gln Pro Ile Met Ser  Ser Ser Gln 
    1580                 1585                 1590             


Ala Leu  Tyr Ile Asp Lys Gly  Gln Tyr Leu His Ile  Pro Arg Ala 
    1595                 1600                 1605             


Gln Val  Ser Asp Ser Ala Thr  Tyr Thr Cys His Val  Ala Asn Val 
    1610                 1615                 1620             


Ala Gly  Thr Ala Glu Lys Ser  Phe His Val Asp Val  Tyr Val Pro 
    1625                 1630                 1635             


Pro Met  Ile Glu Gly Asn Leu  Ala Thr Pro Leu Asn  Lys Gln Val 
    1640                 1645                 1650             


Val Ile  Ala His Ser Leu Thr  Leu Glu Cys Lys Ala  Ala Gly Asn 
    1655                 1660                 1665             


Pro Ser  Pro Ile Leu Thr Trp  Leu Lys Asp Gly Val  Pro Val Lys 
    1670                 1675                 1680             


Ala Asn  Asp Asn Ile Arg Ile  Glu Ala Gly Gly Lys  Lys Leu Glu 
    1685                 1690                 1695             


Ile Met  Ser Ala Gln Glu Ile  Asp Arg Gly Gln Tyr  Ile Cys Val 
    1700                 1705                 1710             


Ala Thr  Ser Val Ala Gly Glu  Lys Glu Ile Lys Tyr  Glu Val Asp 
    1715                 1720                 1725             


Val Leu  Val Pro Pro Ala Ile  Glu Gly Gly Asp Glu  Thr Ser Tyr 
    1730                 1735                 1740             


Phe Ile  Val Met Val Asn Asn  Leu Leu Glu Leu Asp  Cys His Val 
    1745                 1750                 1755             


Thr Gly  Ser Pro Pro Pro Thr  Ile Met Trp Leu Lys  Asp Gly Gln 
    1760                 1765                 1770             


Leu Ile  Asp Glu Arg Asp Gly  Phe Lys Ile Leu Leu  Asn Gly Arg 
    1775                 1780                 1785             


Lys Leu  Val Ile Ala Gln Ala  Gln Val Ser Asn Thr  Gly Leu Tyr 
    1790                 1795                 1800             


Arg Cys  Met Ala Ala Asn Thr  Ala Gly Asp His Lys  Lys Glu Phe 
    1805                 1810                 1815             


Glu Val  Thr Val His Val Pro  Pro Thr Ile Lys Ser  Ser Gly Leu 
    1820                 1825                 1830             


Ser Glu  Arg Val Val Val Lys  Tyr Lys Pro Val Ala  Leu Gln Cys 
    1835                 1840                 1845             


Ile Ala  Asn Gly Ile Pro Asn  Pro Ser Ile Thr Trp  Leu Lys Asp 
    1850                 1855                 1860             


Asp Gln  Pro Val Asn Thr Ala  Gln Gly Asn Leu Lys  Ile Gln Ser 
    1865                 1870                 1875             


Ser Gly  Arg Val Leu Gln Ile  Ala Lys Thr Leu Leu  Glu Asp Ala 
    1880                 1885                 1890             


Gly Arg  Tyr Thr Cys Val Ala  Thr Asn Ala Ala Gly  Glu Thr Gln 
    1895                 1900                 1905             


Gln His  Ile Gln Leu His Val  His Glu Pro Pro Ser  Leu Glu Asp 
    1910                 1915                 1920             


Ala Gly  Lys Met Leu Asn Glu  Thr Val Leu Val Ser  Asn Pro Val 
    1925                 1930                 1935             


Gln Leu  Glu Cys Lys Ala Ala  Gly Asn Pro Val Pro  Val Ile Thr 
    1940                 1945                 1950             


Trp Tyr  Lys Asp Asn Arg Leu  Leu Ser Gly Ser Thr  Ser Met Thr 
    1955                 1960                 1965             


Phe Leu  Asn Arg Gly Gln Ile  Ile Asp Ile Glu Ser  Ala Gln Ile 
    1970                 1975                 1980             


Ser Asp  Ala Gly Ile Tyr Lys  Cys Val Ala Ile Asn  Ser Ala Gly 
    1985                 1990                 1995             


Ala Thr  Glu Leu Phe Tyr Ser  Leu Gln Val His Val  Ala Pro Ser 
    2000                 2005                 2010             


Ile Ser  Gly Ser Asn Asn Met  Val Ala Val Val Val  Asn Asn Pro 
    2015                 2020                 2025             


Val Arg  Leu Glu Cys Glu Ala  Arg Gly Ile Pro Ala  Pro Ser Leu 
    2030                 2035                 2040             


Thr Trp  Leu Lys Asp Gly Ser  Pro Val Ser Ser Phe  Ser Asn Gly 
    2045                 2050                 2055             


Leu Gln  Val Leu Ser Gly Gly  Arg Ile Leu Ala Leu  Thr Ser Ala 
    2060                 2065                 2070             


Gln Ile  Ser Asp Thr Gly Arg  Tyr Thr Cys Val Ala  Val Asn Ala 
    2075                 2080                 2085             


Ala Gly  Glu Lys Gln Arg Asp  Ile Asp Leu Arg Val  Tyr Val Pro 
    2090                 2095                 2100             


Pro Asn  Ile Met Gly Glu Glu  Gln Asn Val Ser Val  Leu Ile Ser 
    2105                 2110                 2115             


Gln Ala  Val Glu Leu Leu Cys  Gln Ser Asp Ala Ile  Pro Pro Pro 
    2120                 2125                 2130             


Thr Leu  Thr Trp Leu Lys Asp  Gly His Pro Leu Leu  Lys Lys Pro 
    2135                 2140                 2145             


Gly Leu  Ser Ile Ser Glu Asn  Arg Ser Val Leu Lys  Ile Glu Asp 
    2150                 2155                 2160             


Ala Gln  Val Gln Asp Thr Gly  Arg Tyr Thr Cys Glu  Ala Thr Asn 
    2165                 2170                 2175             


Val Ala  Gly Lys Thr Glu Lys  Asn Tyr Asn Val Asn  Ile Trp Val 
    2180                 2185                 2190             


Pro Pro  Asn Ile Gly Gly Ser  Asp Glu Leu Thr Gln  Leu Thr Val 
    2195                 2200                 2205             


Ile Glu  Gly Asn Leu Ile Ser  Leu Leu Cys Glu Ser  Ser Gly Ile 
    2210                 2215                 2220             


Pro Pro  Pro Asn Leu Ile Trp  Lys Lys Lys Gly Ser  Pro Val Leu 
    2225                 2230                 2235             


Thr Asp  Ser Met Gly Arg Val  Arg Ile Leu Ser Gly  Gly Arg Gln 
    2240                 2245                 2250             


Leu Gln  Ile Ser Ile Ala Glu  Lys Ser Asp Ala Ala  Leu Tyr Ser 
    2255                 2260                 2265             


Cys Val  Ala Ser Asn Val Ala  Gly Thr Ala Lys Lys  Glu Tyr Asn 
    2270                 2275                 2280             


Leu Gln  Val Tyr Ile Arg Pro  Thr Ile Thr Asn Ser  Gly Ser His 
    2285                 2290                 2295             


Pro Thr  Glu Ile Ile Val Thr  Arg Gly Lys Ser Ile  Ser Leu Glu 
    2300                 2305                 2310             


Cys Glu  Val Gln Gly Ile Pro  Pro Pro Thr Val Thr  Trp Met Lys 
    2315                 2320                 2325             


Asp Gly  His Pro Leu Ile Lys  Ala Lys Gly Val Glu  Ile Leu Asp 
    2330                 2335                 2340             


Glu Gly  His Ile Leu Gln Leu  Lys Asn Ile His Val  Ser Asp Thr 
    2345                 2350                 2355             


Gly Arg  Tyr Val Cys Val Ala  Val Asn Val Ala Gly  Met Thr Asp 
    2360                 2365                 2370             


Lys Lys  Tyr Asp Leu Ser Val  His Ala Pro Pro Ser  Ile Ile Gly 
    2375                 2380                 2385             


Asn His  Arg Ser Pro Glu Asn  Ile Ser Val Val Glu  Lys Asn Ser 
    2390                 2395                 2400             


Val Ser  Leu Thr Cys Glu Ala  Ser Gly Ile Pro Leu  Pro Ser Ile 
    2405                 2410                 2415             


Thr Trp  Phe Lys Asp Gly Trp  Pro Val Ser Leu Ser  Asn Ser Val 
    2420                 2425                 2430             


Arg Ile  Leu Ser Gly Gly Arg  Met Leu Arg Leu Met  Gln Thr Thr 
    2435                 2440                 2445             


Met Glu  Asp Ala Gly Gln Tyr  Thr Cys Val Val Arg  Asn Ala Ala 
    2450                 2455                 2460             


Gly Glu  Glu Arg Lys Ile Phe  Gly Leu Ser Val Leu  Val Pro Pro 
    2465                 2470                 2475             


His Ile  Val Gly Glu Asn Thr  Leu Glu Asp Val Lys  Val Lys Glu 
    2480                 2485                 2490             


Lys Gln  Ser Val Thr Leu Thr  Cys Glu Val Thr Gly  Asn Pro Val 
    2495                 2500                 2505             


Pro Glu  Ile Thr Trp His Lys  Asp Gly Gln Pro Leu  Gln Glu Asp 
    2510                 2515                 2520             


Glu Ala  His His Ile Ile Ser  Gly Gly Arg Phe Leu  Gln Ile Thr 
    2525                 2530                 2535             


Asn Val  Gln Val Pro His Thr  Gly Arg Tyr Thr Cys  Leu Ala Ser 
    2540                 2545                 2550             


Ser Pro  Ala Gly His Lys Ser  Arg Ser Phe Ser Leu  Asn Val Phe 
    2555                 2560                 2565             


Val Ser  Pro Thr Ile Ala Gly  Val Gly Ser Asp Gly  Asn Pro Glu 
    2570                 2575                 2580             


Asp Val  Thr Val Ile Leu Asn  Ser Pro Thr Ser Leu  Val Cys Glu 
    2585                 2590                 2595             


Ala Tyr  Ser Tyr Pro Pro Ala  Thr Ile Thr Trp Phe  Lys Asp Gly 
    2600                 2605                 2610             


Thr Pro  Leu Glu Ser Asn Arg  Asn Ile Arg Ile Leu  Pro Gly Gly 
    2615                 2620                 2625             


Arg Thr  Leu Gln Ile Leu Asn  Ala Gln Glu Asp Asn  Ala Gly Arg 
    2630                 2635                 2640             


Tyr Ser  Cys Val Ala Thr Asn  Glu Ala Gly Glu Met  Ile Lys His 
    2645                 2650                 2655             


Tyr Glu  Val Lys Val Tyr Ile  Pro Pro Ile Ile Asn  Lys Gly Asp 
    2660                 2665                 2670             


Leu Trp  Gly Pro Gly Leu Ser  Pro Lys Glu Val Lys  Ile Lys Val 
    2675                 2680                 2685             


Asn Asn  Thr Leu Thr Leu Glu  Cys Glu Ala Tyr Ala  Ile Pro Ser 
    2690                 2695                 2700             


Ala Ser  Leu Ser Trp Tyr Lys  Asp Gly Gln Pro Leu  Lys Ser Asp 
    2705                 2710                 2715             


Asp His  Val Asn Ile Ala Ala  Asn Gly His Thr Leu  Gln Ile Lys 
    2720                 2725                 2730             


Glu Ala  Gln Ile Ser Asp Thr  Gly Arg Tyr Thr Cys  Val Ala Ser 
    2735                 2740                 2745             


Asn Ile  Ala Gly Glu Asp Glu  Leu Asp Phe Asp Val  Asn Ile Gln 
    2750                 2755                 2760             


Val Pro  Pro Ser Phe Gln Lys  Leu Trp Glu Ile Gly  Asn Met Leu 
    2765                 2770                 2775             


Asp Thr  Gly Arg Asn Gly Glu  Ala Lys Asp Val Ile  Ile Asn Asn 
    2780                 2785                 2790             


Pro Ile  Ser Leu Tyr Cys Glu  Thr Asn Ala Ala Pro  Pro Pro Thr 
    2795                 2800                 2805             


Leu Thr  Trp Tyr Lys Asp Gly  His Pro Leu Thr Ser  Ser Asp Lys 
    2810                 2815                 2820             


Val Leu  Ile Leu Pro Gly Gly  Arg Val Leu Gln Ile  Pro Arg Ala 
    2825                 2830                 2835             


Lys Val  Glu Asp Ala Gly Arg  Tyr Thr Cys Val Ala  Val Asn Glu 
    2840                 2845                 2850             


Ala Gly  Glu Asp Ser Leu Gln  Tyr Asp Val Arg Val  Leu Val Pro 
    2855                 2860                 2865             


Pro Ile  Ile Lys Gly Ala Asn  Ser Asp Leu Pro Glu  Glu Val Thr 
    2870                 2875                 2880             


Val Leu  Val Asn Lys Ser Ala  Leu Ile Glu Cys Leu  Ser Ser Gly 
    2885                 2890                 2895             


Ser Pro  Ala Pro Arg Asn Ser  Trp Gln Lys Asp Gly  Gln Pro Leu 
    2900                 2905                 2910             


Leu Glu  Asp Asp His His Lys  Phe Leu Ser Asn Gly  Arg Ile Leu 
    2915                 2920                 2925             


Gln Ile  Leu Asn Thr Gln Ile  Thr Asp Ile Gly Arg  Tyr Val Cys 
    2930                 2935                 2940             


Val Ala  Glu Asn Thr Ala Gly  Ser Ala Lys Lys Tyr  Phe Asn Leu 
    2945                 2950                 2955             


Asn Val  His Val Pro Pro Ser  Val Ile Gly Pro Lys  Ser Glu Asn 
    2960                 2965                 2970             


Leu Thr  Val Val Val Asn Asn  Phe Ile Ser Leu Thr  Cys Glu Val 
    2975                 2980                 2985             


Ser Gly  Phe Pro Pro Pro Asp  Leu Ser Trp Leu Lys  Asn Glu Gln 
    2990                 2995                 3000             


Pro Ile  Lys Leu Asn Thr Asn  Thr Leu Ile Val Pro  Gly Gly Arg 
    3005                 3010                 3015             


Thr Leu  Gln Ile Ile Arg Ala  Lys Val Ser Asp Gly  Gly Glu Tyr 
    3020                 3025                 3030             


Thr Cys  Ile Ala Ile Asn Gln  Ala Gly Glu Ser Lys  Lys Lys Phe 
    3035                 3040                 3045             


Ser Leu  Thr Val Tyr Val Pro  Pro Ser Ile Lys Asp  His Asp Ser 
    3050                 3055                 3060             


Glu Ser  Leu Ser Val Val Asn  Val Arg Glu Gly Thr  Ser Val Ser 
    3065                 3070                 3075             


Leu Glu  Cys Glu Ser Asn Ala  Val Pro Pro Pro Val  Ile Thr Trp 
    3080                 3085                 3090             


Tyr Lys  Asn Gly Arg Met Ile  Thr Glu Ser Thr His  Val Glu Ile 
    3095                 3100                 3105             


Leu Ala  Asp Gly Gln Met Leu  His Ile Lys Lys Ala  Glu Val Ser 
    3110                 3115                 3120             


Asp Thr  Gly Gln Tyr Val Cys  Arg Ala Ile Asn Val  Ala Gly Arg 
    3125                 3130                 3135             


Asp Asp  Lys Asn Phe His Leu  Asn Val Tyr Val Pro  Pro Ser Ile 
    3140                 3145                 3150             


Glu Gly  Pro Glu Arg Glu Val  Ile Val Glu Thr Ile  Ser Asn Pro 
    3155                 3160                 3165             


Val Thr  Leu Thr Cys Asp Ala  Thr Gly Ile Pro Pro  Pro Thr Ile 
    3170                 3175                 3180             


Ala Trp  Leu Lys Asn His Lys  Arg Ile Glu Asn Ser  Asp Ser Leu 
    3185                 3190                 3195             


Glu Val  Arg Ile Leu Ser Gly  Gly Ser Lys Leu Gln  Ile Ala Arg 
    3200                 3205                 3210             


Ser Gln  His Ser Asp Ser Gly  Asn Tyr Thr Cys Ile  Ala Ser Asn 
    3215                 3220                 3225             


Met Glu  Gly Lys Ala Gln Lys  Tyr Tyr Phe Leu Ser  Ile Gln Val 
    3230                 3235                 3240             


Pro Pro  Ser Val Ala Gly Ala  Glu Ile Pro Ser Asp  Val Ser Val 
    3245                 3250                 3255             


Leu Leu  Gly Glu Asn Val Glu  Leu Val Cys Asn Ala  Asn Gly Ile 
    3260                 3265                 3270             


Pro Thr  Pro Leu Ile Gln Trp  Leu Lys Asp Gly Lys  Pro Ile Ala 
    3275                 3280                 3285             


Ser Gly  Glu Thr Glu Arg Ile  Arg Val Ser Ala Asn  Gly Ser Thr 
    3290                 3295                 3300             


Leu Asn  Ile Tyr Gly Ala Leu  Thr Ser Asp Thr Gly  Lys Tyr Thr 
    3305                 3310                 3315             


Cys Val  Ala Thr Asn Pro Ala  Gly Glu Glu Asp Arg  Ile Phe Asn 
    3320                 3325                 3330             


Leu Asn  Val Tyr Val Thr Pro  Thr Ile Arg Gly Asn  Lys Asp Glu 
    3335                 3340                 3345             


Ala Glu  Lys Leu Met Thr Leu  Val Asp Thr Ser Ile  Asn Ile Glu 
    3350                 3355                 3360             


Cys Arg  Ala Thr Gly Thr Pro  Pro Pro Gln Ile Asn  Trp Leu Lys 
    3365                 3370                 3375             


Asn Gly  Leu Pro Leu Pro Leu  Ser Ser His Ile Arg  Leu Leu Ala 
    3380                 3385                 3390             


Ala Gly  Gln Val Ile Arg Ile  Val Arg Ala Gln Val  Ser Asp Val 
    3395                 3400                 3405             


Ala Val  Tyr Thr Cys Val Ala  Ser Asn Arg Ala Gly  Val Asp Asn 
    3410                 3415                 3420             


Lys His  Tyr Asn Leu Gln Val  Phe Ala Pro Pro Asn  Met Asp Asn 
    3425                 3430                 3435             


Ser Met  Gly Thr Glu Glu Ile  Thr Val Leu Lys Gly  Ser Ser Thr 
    3440                 3445                 3450             


Ser Met  Ala Cys Ile Thr Asp  Gly Thr Pro Ala Pro  Ser Met Ala 
    3455                 3460                 3465             


Trp Leu  Arg Asp Gly Gln Pro  Leu Gly Leu Asp Ala  His Leu Thr 
    3470                 3475                 3480             


Val Ser  Thr His Gly Met Val  Leu Gln Leu Leu Lys  Ala Glu Thr 
    3485                 3490                 3495             


Glu Asp  Ser Gly Lys Tyr Thr  Cys Ile Ala Ser Asn  Glu Ala Gly 
    3500                 3505                 3510             


Glu Val  Ser Lys His Phe Ile  Leu Lys Val Leu Glu  Pro Pro His 
    3515                 3520                 3525             


Ile Asn  Gly Ser Glu Glu His  Glu Glu Ile Ser Val  Ile Val Asn 
    3530                 3535                 3540             


Asn Pro  Leu Glu Leu Thr Cys  Ile Ala Ser Gly Ile  Pro Ala Pro 
    3545                 3550                 3555             


Lys Met  Thr Trp Met Lys Asp  Gly Arg Pro Leu Pro  Gln Thr Asp 
    3560                 3565                 3570             


Gln Val  Gln Thr Leu Gly Gly  Gly Glu Val Leu Arg  Ile Ser Thr 
    3575                 3580                 3585             


Ala Gln  Val Glu Asp Thr Gly  Arg Tyr Thr Cys Leu  Ala Ser Ser 
    3590                 3595                 3600             


Pro Ala  Gly Asp Asp Asp Lys  Glu Tyr Leu Val Arg  Val His Val 
    3605                 3610                 3615             


Pro Pro  Asn Ile Ala Gly Thr  Asp Glu Pro Arg Asp  Ile Thr Val 
    3620                 3625                 3630             


Leu Arg  Asn Arg Gln Val Thr  Leu Glu Cys Lys Ser  Asp Ala Val 
    3635                 3640                 3645             


Pro Pro  Pro Val Ile Thr Trp  Leu Arg Asn Gly Glu  Arg Leu Gln 
    3650                 3655                 3660             


Ala Thr  Pro Arg Val Arg Ile  Leu Ser Gly Gly Arg  Tyr Leu Gln 
    3665                 3670                 3675             


Ile Asn  Asn Ala Asp Leu Gly  Asp Thr Ala Asn Tyr  Thr Cys Val 
    3680                 3685                 3690             


Ala Ser  Asn Ile Ala Gly Lys  Thr Thr Arg Glu Phe  Ile Leu Thr 
    3695                 3700                 3705             


Val Asn  Val Pro Pro Asn Ile  Lys Gly Gly Pro Gln  Ser Leu Val 
    3710                 3715                 3720             


Ile Leu  Leu Asn Lys Ser Thr  Val Leu Glu Cys Ile  Ala Glu Gly 
    3725                 3730                 3735             


Val Pro  Thr Pro Arg Ile Thr  Trp Arg Lys Asp Gly  Ala Val Leu 
    3740                 3745                 3750             


Ala Gly  Asn His Ala Arg Tyr  Ser Ile Leu Glu Asn  Gly Phe Leu 
    3755                 3760                 3765             


His Ile  Gln Ser Ala His Val  Thr Asp Thr Gly Arg  Tyr Leu Cys 
    3770                 3775                 3780             


Met Ala  Thr Asn Ala Ala Gly  Thr Asp Arg Arg Arg  Ile Asp Leu 
    3785                 3790                 3795             


Gln Val  His Val Pro Pro Ser  Ile Ala Pro Gly Pro  Thr Asn Met 
    3800                 3805                 3810             


Thr Val  Ile Val Asn Val Gln  Thr Thr Leu Ala Cys  Glu Ala Thr 
    3815                 3820                 3825             


Gly Ile  Pro Lys Pro Ser Ile  Asn Trp Arg Lys Asn  Gly His Leu 
    3830                 3835                 3840             


Leu Asn  Val Asp Gln Asn Gln  Asn Ser Tyr Arg Leu  Leu Ser Ser 
    3845                 3850                 3855             


Gly Ser  Leu Val Ile Ile Ser  Pro Ser Val Asp Asp  Thr Ala Thr 
    3860                 3865                 3870             


Tyr Glu  Cys Thr Val Thr Asn  Gly Ala Gly Asp Asp  Lys Arg Thr 
    3875                 3880                 3885             


Val Asp  Leu Thr Val Gln Val  Pro Pro Ser Ile Ala  Asp Glu Pro 
    3890                 3895                 3900             


Thr Asp  Phe Leu Val Thr Lys  His Ala Pro Ala Val  Ile Thr Cys 
    3905                 3910                 3915             


Thr Ala  Ser Gly Val Pro Phe  Pro Ser Ile His Trp  Thr Lys Asn 
    3920                 3925                 3930             


Gly Ile  Arg Leu Leu Pro Arg  Gly Asp Gly Tyr Arg  Ile Leu Ser 
    3935                 3940                 3945             


Ser Gly  Ala Ile Glu Ile Leu  Ala Thr Gln Leu Asn  His Ala Gly 
    3950                 3955                 3960             


Arg Tyr  Thr Cys Val Ala Arg  Asn Ala Ala Gly Ser  Ala His Arg 
    3965                 3970                 3975             


His Val  Thr Leu His Val His  Glu Pro Pro Val Ile  Gln Pro Gln 
    3980                 3985                 3990             


Pro Ser  Glu Leu His Val Ile  Leu Asn Asn Pro Ile  Leu Leu Pro 
    3995                 4000                 4005             


Cys Glu  Ala Thr Gly Thr Pro  Ser Pro Phe Ile Thr  Trp Gln Lys 
    4010                 4015                 4020             


Glu Gly  Ile Asn Val Asn Thr  Ser Gly Arg Asn His  Ala Val Leu 
    4025                 4030                 4035             


Pro Ser  Gly Gly Leu Gln Ile  Ser Arg Ala Val Arg  Glu Asp Ala 
    4040                 4045                 4050             


Gly Thr  Tyr Met Cys Val Ala  Gln Asn Pro Ala Gly  Thr Ala Leu 
    4055                 4060                 4065             


Gly Lys  Ile Lys Leu Asn Val  Gln Val Pro Pro Val  Ile Ser Pro 
    4070                 4075                 4080             


His Leu  Lys Glu Tyr Val Ile  Ala Val Asp Lys Pro  Ile Thr Leu 
    4085                 4090                 4095             


Ser Cys  Glu Ala Asp Gly Leu  Pro Pro Pro Asp Ile  Thr Trp His 
    4100                 4105                 4110             


Lys Asp  Gly Arg Ala Ile Val  Glu Ser Ile Arg Gln  Arg Val Leu 
    4115                 4120                 4125             


Ser Ser  Gly Ser Leu Gln Ile  Ala Phe Val Gln Pro  Gly Asp Ala 
    4130                 4135                 4140             


Gly His  Tyr Thr Cys Met Ala  Ala Asn Val Ala Gly  Ser Ser Ser 
    4145                 4150                 4155             


Thr Ser  Thr Lys Leu Thr Val  His Val Pro Pro Arg  Ile Arg Ser 
    4160                 4165                 4170             


Thr Glu  Gly His Tyr Thr Val  Asn Glu Asn Ser Gln  Ala Ile Leu 
    4175                 4180                 4185             


Pro Cys  Val Ala Asp Gly Ile  Pro Thr Pro Ala Ile  Asn Trp Lys 
    4190                 4195                 4200             


Lys Asp  Asn Val Leu Leu Ala  Asn Leu Leu Gly Lys  Tyr Thr Ala 
    4205                 4210                 4215             


Glu Pro  Tyr Gly Glu Leu Ile  Leu Glu Asn Val Val  Leu Glu Asp 
    4220                 4225                 4230             


Ser Gly  Phe Tyr Thr Cys Val  Ala Asn Asn Ala Ala  Gly Glu Asp 
    4235                 4240                 4245             


Thr His  Thr Val Ser Leu Thr  Val His Val Leu Pro  Thr Phe Thr 
    4250                 4255                 4260             


Glu Leu  Pro Gly Asp Val Ser  Leu Asn Lys Gly Glu  Gln Leu Arg 
    4265                 4270                 4275             


Leu Ser  Cys Lys Ala Thr Gly  Ile Pro Leu Pro Lys  Leu Thr Trp 
    4280                 4285                 4290             


Thr Phe  Asn Asn Asn Ile Ile  Pro Ala His Phe Asp  Ser Val Asn 
    4295                 4300                 4305             


Gly His  Ser Glu Leu Val Ile  Glu Arg Val Ser Lys  Glu Asp Ser 
    4310                 4315                 4320             


Gly Thr  Tyr Val Cys Thr Ala  Glu Asn Ser Val Gly  Phe Val Lys 
    4325                 4330                 4335             


Ala Ile  Gly Phe Val Tyr Val  Lys Glu Pro Pro Val  Phe Lys Gly 
    4340                 4345                 4350             


Asp Tyr  Pro Ser Asn Trp Ile  Glu Pro Leu Gly Gly  Asn Ala Ile 
    4355                 4360                 4365             


Leu Asn  Cys Glu Val Lys Gly  Asp Pro Thr Pro Thr  Ile Gln Trp 
    4370                 4375                 4380             


Asn Arg  Lys Gly Val Asp Ile  Glu Ile Ser His Arg  Ile Arg Gln 
    4385                 4390                 4395             


Leu Gly  Asn Gly Ser Leu Ala  Ile Tyr Gly Thr Val  Asn Glu Asp 
    4400                 4405                 4410             


Ala Gly  Asp Tyr Thr Cys Val  Ala Thr Asn Glu Ala  Gly Val Val 
    4415                 4420                 4425             


Glu Arg  Ser Met Ser Leu Thr  Leu Gln Ser Pro Pro  Ile Ile Thr 
    4430                 4435                 4440             


Leu Glu  Pro Val Glu Thr Val  Ile Asn Ala Gly Gly  Lys Ile Ile 
    4445                 4450                 4455             


Leu Asn  Cys Gln Ala Thr Gly  Glu Pro Gln Pro Thr  Ile Thr Trp 
    4460                 4465                 4470             


Ser Arg  Gln Gly His Ser Ile  Ser Trp Asp Asp Arg  Val Asn Val 
    4475                 4480                 4485             


Leu Ser  Asn Asn Ser Leu Tyr  Ile Ala Asp Ala Gln  Lys Glu Asp 
    4490                 4495                 4500             


Thr Ser  Glu Phe Glu Cys Val  Ala Arg Asn Leu Met  Gly Ser Val 
    4505                 4510                 4515             


Leu Val  Arg Val Pro Val Ile  Val Gln Val His Gly  Gly Phe Ser 
    4520                 4525                 4530             


Gln Trp  Ser Ala Trp Arg Ala  Cys Ser Val Thr Cys  Gly Lys Gly 
    4535                 4540                 4545             


Ile Gln  Lys Arg Ser Arg Leu  Cys Asn Gln Pro Leu  Pro Ala Asn 
    4550                 4555                 4560             


Gly Gly  Lys Pro Cys Gln Gly  Ser Asp Leu Glu Met  Arg Asn Cys 
    4565                 4570                 4575             


Gln Asn  Lys Pro Cys Pro Val  Asp Gly Ser Trp Ser  Glu Trp Ser 
    4580                 4585                 4590             


Leu Trp  Glu Glu Cys Thr Arg  Ser Cys Gly Arg Gly  Asn Gln Thr 
    4595                 4600                 4605             


Arg Thr  Arg Thr Cys Asn Asn  Pro Ser Val Gln His  Gly Gly Arg 
    4610                 4615                 4620             


Pro Cys  Glu Gly Asn Ala Val  Glu Ile Ile Met Cys  Asn Ile Arg 
    4625                 4630                 4635             


Pro Cys  Pro Val His Gly Ala  Trp Ser Ala Trp Gln  Pro Trp Gly 
    4640                 4645                 4650             


Thr Cys  Ser Glu Ser Cys Gly  Lys Gly Thr Gln Thr  Arg Ala Arg 
    4655                 4660                 4665             


Leu Cys  Asn Asn Pro Pro Pro  Ala Phe Gly Gly Ser  Tyr Cys Asp 
    4670                 4675                 4680             


Gly Ala  Glu Thr Gln Met Gln  Val Cys Asn Glu Arg  Asn Cys Pro 
    4685                 4690                 4695             


Ile His  Gly Lys Trp Ala Thr  Trp Ala Ser Trp Ser  Ala Cys Ser 
    4700                 4705                 4710             


Val Ser  Cys Gly Gly Gly Ala  Arg Gln Arg Thr Arg  Gly Cys Ser 
    4715                 4720                 4725             


Asp Pro  Val Pro Gln Tyr Gly  Gly Arg Lys Cys Glu  Gly Ser Asp 
    4730                 4735                 4740             


Val Gln  Ser Asp Phe Cys Asn  Ser Asp Pro Cys Pro  Thr His Gly 
    4745                 4750                 4755             


Asn Trp  Ser Pro Trp Ser Gly  Trp Gly Thr Cys Ser  Arg Thr Cys 
    4760                 4765                 4770             


Asn Gly  Gly Gln Met Arg Arg  Tyr Arg Thr Cys Asp  Asn Pro Pro 
    4775                 4780                 4785             


Pro Ser  Asn Gly Gly Arg Ala  Cys Gly Gly Pro Asp  Ser Gln Ile 
    4790                 4795                 4800             


Gln Arg  Cys Asn Thr Asp Met  Cys Pro Val Asp Gly  Ser Trp Gly 
    4805                 4810                 4815             


Ser Trp  His Ser Trp Ser Gln  Cys Ser Ala Ser Cys  Gly Gly Gly 
    4820                 4825                 4830             


Glu Lys  Thr Arg Lys Arg Leu  Cys Asp His Pro Val  Pro Val Lys 
    4835                 4840                 4845             


Gly Gly  Arg Pro Cys Pro Gly  Asp Thr Thr Gln Val  Thr Arg Cys 
    4850                 4855                 4860             


Asn Val  Gln Ala Cys Pro Gly  Gly Pro Gln Arg Ala  Arg Gly Ser 
    4865                 4870                 4875             


Val Ile  Gly Asn Ile Asn Asp  Val Glu Phe Gly Ile  Ala Phe Leu 
    4880                 4885                 4890             


Asn Ala  Thr Ile Thr Asp Ser  Pro Asn Ser Asp Thr  Arg Ile Ile 
    4895                 4900                 4905             


Arg Ala  Lys Ile Thr Asn Val  Pro Arg Ser Leu Gly  Ser Ala Met 
    4910                 4915                 4920             


Arg Lys  Ile Val Ser Ile Leu  Asn Pro Ile Tyr Trp  Thr Thr Ala 
    4925                 4930                 4935             


Lys Glu  Ile Gly Glu Ala Val  Asn Gly Phe Thr Leu  Thr Asn Ala 
    4940                 4945                 4950             


Val Phe  Lys Arg Glu Thr Gln  Val Glu Phe Ala Thr  Gly Glu Ile 
    4955                 4960                 4965             


Leu Gln  Met Ser His Ile Ala  Arg Gly Leu Asp Ser  Asp Gly Ser 
    4970                 4975                 4980             


Leu Leu  Leu Asp Ile Val Val  Ser Gly Tyr Val Leu  Gln Leu Gln 
    4985                 4990                 4995             


Ser Pro  Ala Glu Val Thr Val  Lys Asp Tyr Thr Glu  Asp Tyr Ile 
    5000                 5005                 5010             


Gln Thr  Gly Pro Gly Gln Leu  Tyr Ala Tyr Ser Thr  Arg Leu Phe 
    5015                 5020                 5025             


Thr Ile  Asp Gly Ile Ser Ile  Pro Tyr Thr Trp Asn  His Thr Val 
    5030                 5035                 5040             


Phe Tyr  Asp Gln Ala Gln Gly  Arg Met Pro Phe Leu  Val Glu Thr 
    5045                 5050                 5055             


Leu His  Ala Ser Ser Val Glu  Ser Asp Tyr Asn Gln  Ile Glu Glu 
    5060                 5065                 5070             


Thr Leu  Gly Phe Lys Ile His  Ala Ser Ile Ser Lys  Gly Asp Arg 
    5075                 5080                 5085             


Ser Asn  Gln Cys Pro Ser Gly  Phe Thr Leu Asp Ser  Val Gly Pro 
    5090                 5095                 5100             


Phe Cys  Ala Asp Glu Asp Glu  Cys Ala Ala Gly Asn  Pro Cys Ser 
    5105                 5110                 5115             


His Ser  Cys His Asn Ala Met  Gly Thr Tyr Tyr Cys  Ser Cys Pro 
    5120                 5125                 5130             


Lys Gly  Leu Thr Ile Ala Ala  Asp Gly Arg Thr Cys  Gln Asp Ile 
    5135                 5140                 5145             


Asp Glu  Cys Ala Leu Gly Arg  His Thr Cys His Ala  Gly Gln Asp 
    5150                 5155                 5160             


Cys Asp  Asn Thr Ile Gly Ser  Tyr Arg Cys Val Val  Arg Cys Gly 
    5165                 5170                 5175             


Ser Gly  Phe Arg Arg Thr Ser  Asp Gly Leu Ser Cys  Gln Asp Ile 
    5180                 5185                 5190             


Asn Glu  Cys Gln Glu Ser Ser  Pro Cys His Gln Arg  Cys Phe Asn 
    5195                 5200                 5205             


Ala Ile  Gly Ser Phe His Cys  Gly Cys Glu Pro Gly  Tyr Gln Leu 
    5210                 5215                 5220             


Lys Gly  Arg Lys Cys Met Asp  Val Asn Glu Cys Arg  Gln Asn Val 
    5225                 5230                 5235             


Cys Arg  Pro Asp Gln His Cys  Lys Asn Thr Arg Gly  Gly Tyr Lys 
    5240                 5245                 5250             


Cys Ile  Asp Leu Cys Pro Asn  Gly Met Thr Lys Ala  Glu Asn Gly 
    5255                 5260                 5265             


Thr Cys  Ile Asp Ile Asp Glu  Cys Lys Asp Gly Thr  His Gln Cys 
    5270                 5275                 5280             


Arg Tyr  Asn Gln Ile Cys Glu  Asn Thr Arg Gly Ser  Tyr Arg Cys 
    5285                 5290                 5295             


Val Cys  Pro Arg Gly Tyr Arg  Ser Gln Gly Val Gly  Arg Pro Cys 
    5300                 5305                 5310             


Met Asp  Ile Asn Glu Cys Glu  Gln Val Pro Lys Pro  Cys Ala His 
    5315                 5320                 5325             


Gln Cys  Ser Asn Thr Pro Gly  Ser Phe Lys Cys Ile  Cys Pro Pro 
    5330                 5335                 5340             


Gly Gln  His Leu Leu Gly Asp  Gly Lys Ser Cys Ala  Gly Leu Glu 
    5345                 5350                 5355             


Arg Leu  Pro Asn Tyr Gly Thr  Gln Tyr Ser Ser Tyr  Asn Leu Ala 
    5360                 5365                 5370             


Arg Phe  Ser Pro Val Arg Asn  Asn Tyr Gln Pro Gln  Gln His Tyr 
    5375                 5380                 5385             


Arg Gln  Tyr Ser His Leu Tyr  Ser Ser Tyr Ser Glu  Tyr Arg Asn 
    5390                 5395                 5400             


Ser Arg  Thr Ser Leu Ser Arg  Thr Arg Arg Thr Ile  Arg Lys Thr 
    5405                 5410                 5415             


Cys Pro  Glu Gly Ser Glu Ala  Ser His Asp Thr Cys  Val Asp Ile 
    5420                 5425                 5430             


Asp Glu  Cys Glu Asn Thr Asp  Ala Cys Gln His Glu  Cys Lys Asn 
    5435                 5440                 5445             


Thr Phe  Gly Ser Tyr Gln Cys  Ile Cys Pro Pro Gly  Tyr Gln Leu 
    5450                 5455                 5460             


Thr His  Asn Gly Lys Thr Cys  Gln Asp Ile Asp Glu  Cys Leu Glu 
    5465                 5470                 5475             


Gln Asn  Val His Cys Gly Pro  Asn Arg Met Cys Phe  Asn Met Arg 
    5480                 5485                 5490             


Gly Ser  Tyr Gln Cys Ile Asp  Thr Pro Cys Pro Pro  Asn Tyr Gln 
    5495                 5500                 5505             


Arg Asp  Pro Val Ser Gly Phe  Cys Leu Lys Asn Cys  Pro Pro Asn 
    5510                 5515                 5520             


Asp Leu  Glu Cys Ala Leu Ser  Pro Tyr Ala Leu Glu  Tyr Lys Leu 
    5525                 5530                 5535             


Val Ser  Leu Pro Phe Gly Ile  Ala Thr Asn Gln Asp  Leu Ile Arg 
    5540                 5545                 5550             


Leu Val  Ala Tyr Thr Gln Asp  Gly Val Met His Pro  Arg Thr Thr 
    5555                 5560                 5565             


Phe Leu  Met Val Asp Glu Glu  Gln Thr Val Pro Phe  Ala Leu Arg 
    5570                 5575                 5580             


Asp Glu  Asn Leu Lys Gly Val  Val Tyr Thr Thr Arg  Pro Leu Arg 
    5585                 5590                 5595             


Glu Ala  Glu Thr Tyr Arg Met  Arg Val Arg Ala Ser  Ser Tyr Ser 
    5600                 5605                 5610             


Ala Asn  Gly Thr Ile Glu Tyr  Gln Thr Thr Phe Ile  Val Tyr Ile 
    5615                 5620                 5625             


Ala Val  Ser Ala Tyr Pro Tyr  
    5630                 5635 


<210>  169
<211>  6947
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (27)..(6146)

<400>  169
gggctgaaag acacacagaa gtcttc atg gat ata gtt gat aca ttt aat cat        53
                             Met Asp Ile Val Asp Thr Phe Asn His          
                             1               5                            

tta att cct act gaa cac tta gat gat gcc cta ttt cta gga tcc aac        101
Leu Ile Pro Thr Glu His Leu Asp Asp Ala Leu Phe Leu Gly Ser Asn           
10                  15                  20                  25            

ctg gag aat gaa gtc tgt gag gat ttt agt gca agt caa aat gtc tta        149
Leu Glu Asn Glu Val Cys Glu Asp Phe Ser Ala Ser Gln Asn Val Leu           
                30                  35                  40                

gag gac tcg ctg aag aac atg ctc agc gat aag gat cct atg cta gga        197
Glu Asp Ser Leu Lys Asn Met Leu Ser Asp Lys Asp Pro Met Leu Gly           
            45                  50                  55                    

tct gca agt aac cag ttc tgt ttg cct gtt ttg gat agc aat gat ccc        245
Ser Ala Ser Asn Gln Phe Cys Leu Pro Val Leu Asp Ser Asn Asp Pro           
        60                  65                  70                        

aat ttc cag atg cct tgt tca aca gtt gtt ggt ctt gac gat att atg        293
Asn Phe Gln Met Pro Cys Ser Thr Val Val Gly Leu Asp Asp Ile Met           
    75                  80                  85                            

gat gaa gga gtt gtt aaa gaa agt ggc aat gat acc att gat gaa gaa        341
Asp Glu Gly Val Val Lys Glu Ser Gly Asn Asp Thr Ile Asp Glu Glu           
90                  95                  100                 105           

gaa ctg att tta cct aac agg aac tta agg gac aag gta gaa gaa aat        389
Glu Leu Ile Leu Pro Asn Arg Asn Leu Arg Asp Lys Val Glu Glu Asn           
                110                 115                 120               

tca gtg aga tct cca aga aaa tca cct cgt tta atg gca caa gaa caa        437
Ser Val Arg Ser Pro Arg Lys Ser Pro Arg Leu Met Ala Gln Glu Gln           
            125                 130                 135                   

gta aga agt ttg cga cag agc act att gcc aag cgt tca aat gca gca        485
Val Arg Ser Leu Arg Gln Ser Thr Ile Ala Lys Arg Ser Asn Ala Ala           
        140                 145                 150                       

cca tta agt aac aca aaa aaa gca tct ggg aag act gta tct act gct        533
Pro Leu Ser Asn Thr Lys Lys Ala Ser Gly Lys Thr Val Ser Thr Ala           
    155                 160                 165                           

aaa gca gga gtg aaa caa cca gaa agg agt cag gtt aaa gaa gaa gta        581
Lys Ala Gly Val Lys Gln Pro Glu Arg Ser Gln Val Lys Glu Glu Val           
170                 175                 180                 185           

tgt atg tca ctg aaa cct gag tac cat aag gag aat aga agg tgc agc        629
Cys Met Ser Leu Lys Pro Glu Tyr His Lys Glu Asn Arg Arg Cys Ser           
                190                 195                 200               

cga aat agc gga caa att gaa gtg gta cct gaa gta tca gtg tct tca        677
Arg Asn Ser Gly Gln Ile Glu Val Val Pro Glu Val Ser Val Ser Ser           
            205                 210                 215                   

agt cat tct tca gtg tca tct tgt ctt gaa atg aag gat gaa gat gga        725
Ser His Ser Ser Val Ser Ser Cys Leu Glu Met Lys Asp Glu Asp Gly           
        220                 225                 230                       

tta gat tct aag cat aag tgt aat aat ccg gga gaa ata gat gtg cca        773
Leu Asp Ser Lys His Lys Cys Asn Asn Pro Gly Glu Ile Asp Val Pro           
    235                 240                 245                           

tct cat gaa tta aat tgt tca ctt ctt tca gag act tgt gtt act att        821
Ser His Glu Leu Asn Cys Ser Leu Leu Ser Glu Thr Cys Val Thr Ile           
250                 255                 260                 265           

gga gaa aag aaa aat gaa gct ttg atg gaa tgt aaa gcc aag cct gtt        869
Gly Glu Lys Lys Asn Glu Ala Leu Met Glu Cys Lys Ala Lys Pro Val           
                270                 275                 280               

ggt agt cca ttg ttt aag ttt tca gat aaa gaa gaa cat gaa caa aat        917
Gly Ser Pro Leu Phe Lys Phe Ser Asp Lys Glu Glu His Glu Gln Asn           
            285                 290                 295                   

gat tcc att tca ggt aaa acg ggt gag act gtt gtt gaa gaa atg ata        965
Asp Ser Ile Ser Gly Lys Thr Gly Glu Thr Val Val Glu Glu Met Ile           
        300                 305                 310                       

gca aca aga aaa gtt gaa caa gat tca aag gag aca gta aaa tta tcc       1013
Ala Thr Arg Lys Val Glu Gln Asp Ser Lys Glu Thr Val Lys Leu Ser           
    315                 320                 325                           

cat gaa gat gac cat att ctt gag gac gct gga tct tct gat att tct       1061
His Glu Asp Asp His Ile Leu Glu Asp Ala Gly Ser Ser Asp Ile Ser           
330                 335                 340                 345           

agt gat gct gct tgt aca aat cca aat aag aca gaa aac agc ctt gta       1109
Ser Asp Ala Ala Cys Thr Asn Pro Asn Lys Thr Glu Asn Ser Leu Val           
                350                 355                 360               

ggt ttg cct agt tgt gta gat gaa gtg act gaa tgt aat ttg gaa ttg       1157
Gly Leu Pro Ser Cys Val Asp Glu Val Thr Glu Cys Asn Leu Glu Leu           
            365                 370                 375                   

aag gat acc atg ggt att gct gat aaa act gag aac acc ctt gaa aga       1205
Lys Asp Thr Met Gly Ile Ala Asp Lys Thr Glu Asn Thr Leu Glu Arg           
        380                 385                 390                       

aat aaa att gaa ccg ttg ggt tat tgt gaa gat gcg gag tct aat agg       1253
Asn Lys Ile Glu Pro Leu Gly Tyr Cys Glu Asp Ala Glu Ser Asn Arg           
    395                 400                 405                           

cag ttg gag agc act gag ttt aat aaa tca aac tta gag gtg gtt gat       1301
Gln Leu Glu Ser Thr Glu Phe Asn Lys Ser Asn Leu Glu Val Val Asp           
410                 415                 420                 425           

act agt act ttt gga ccg gaa agt aat atc ttg gaa aat gct att tgt       1349
Thr Ser Thr Phe Gly Pro Glu Ser Asn Ile Leu Glu Asn Ala Ile Cys           
                430                 435                 440               

gat gtg cct gac caa aat tca aaa cag ttg aat gct ata gaa agt act       1397
Asp Val Pro Asp Gln Asn Ser Lys Gln Leu Asn Ala Ile Glu Ser Thr           
            445                 450                 455                   

aaa ata gag tcc cat gaa aca gca aac ctt cag gat gac aga aac agc       1445
Lys Ile Glu Ser His Glu Thr Ala Asn Leu Gln Asp Asp Arg Asn Ser           
        460                 465                 470                       

cag tca agt agc gtt tct tac tta gag tca aaa agt gta aaa tcc aaa       1493
Gln Ser Ser Ser Val Ser Tyr Leu Glu Ser Lys Ser Val Lys Ser Lys           
    475                 480                 485                           

cat aca aaa cct gta att cat tct aag caa aac atg acc aca gat gct       1541
His Thr Lys Pro Val Ile His Ser Lys Gln Asn Met Thr Thr Asp Ala           
490                 495                 500                 505           

ccg aag aaa att gtt gca gca aag tat gaa gta ata cat agc aaa act       1589
Pro Lys Lys Ile Val Ala Ala Lys Tyr Glu Val Ile His Ser Lys Thr           
                510                 515                 520               

aaa gtt aat gtc aaa agt gtg aaa cga aat act gat gta cca gaa tct       1637
Lys Val Asn Val Lys Ser Val Lys Arg Asn Thr Asp Val Pro Glu Ser           
            525                 530                 535                   

cag caa aat ttt cat agg cca gtc aaa gtc aga aaa aaa caa att gat       1685
Gln Gln Asn Phe His Arg Pro Val Lys Val Arg Lys Lys Gln Ile Asp           
        540                 545                 550                       

aag gag cca aag att cag agt tgc aat tct ggg gtt aaa tct gtg aaa       1733
Lys Glu Pro Lys Ile Gln Ser Cys Asn Ser Gly Val Lys Ser Val Lys           
    555                 560                 565                           

aac caa gct cat tct gta ctg aaa aaa aca tta cag gat caa act tta       1781
Asn Gln Ala His Ser Val Leu Lys Lys Thr Leu Gln Asp Gln Thr Leu           
570                 575                 580                 585           

gta caa att ttc aag ccc tta act cat tct ttg agt gat aag tca cac       1829
Val Gln Ile Phe Lys Pro Leu Thr His Ser Leu Ser Asp Lys Ser His           
                590                 595                 600               

gct cat cct ggt tgc ttg aaa gaa cct cat cat cct gca caa act gga       1877
Ala His Pro Gly Cys Leu Lys Glu Pro His His Pro Ala Gln Thr Gly           
            605                 610                 615                   

cat gta tca cat tct agc cag aaa cag tgt cat aag cct cag caa cag       1925
His Val Ser His Ser Ser Gln Lys Gln Cys His Lys Pro Gln Gln Gln           
        620                 625                 630                       

gcc cca gca atg aaa acc aat agt cac gtg aag gaa gag ctt gaa cac       1973
Ala Pro Ala Met Lys Thr Asn Ser His Val Lys Glu Glu Leu Glu His           
    635                 640                 645                           

cca ggc gtt gag cat ttt aag gaa gag gat aaa ctg aaa ctg aaa aaa       2021
Pro Gly Val Glu His Phe Lys Glu Glu Asp Lys Leu Lys Leu Lys Lys           
650                 655                 660                 665           

cct gag aag aac cta caa ccc cgc caa aga aga agc agc aaa agt ttt       2069
Pro Glu Lys Asn Leu Gln Pro Arg Gln Arg Arg Ser Ser Lys Ser Phe           
                670                 675                 680               

tct tta gat gag cca cca ttg ttc att cca gat aac ata gct acc ata       2117
Ser Leu Asp Glu Pro Pro Leu Phe Ile Pro Asp Asn Ile Ala Thr Ile           
            685                 690                 695                   

aga aga gaa ggc tct gat cat agc tcc tca ttt gaa agc aaa tat atg       2165
Arg Arg Glu Gly Ser Asp His Ser Ser Ser Phe Glu Ser Lys Tyr Met           
        700                 705                 710                       

tgg act ccc agc aag cag tgt ggg ttt tgc aaa aaa cca cat ggc aac       2213
Trp Thr Pro Ser Lys Gln Cys Gly Phe Cys Lys Lys Pro His Gly Asn           
    715                 720                 725                           

agg ttt atg gtt ggc tgt ggg aga tgt gat gac tgg ttt cat ggt gat       2261
Arg Phe Met Val Gly Cys Gly Arg Cys Asp Asp Trp Phe His Gly Asp           
730                 735                 740                 745           

tgt gtt ggg tta agt ctt tct caa gca cag cag atg ggc gag gaa gac       2309
Cys Val Gly Leu Ser Leu Ser Gln Ala Gln Gln Met Gly Glu Glu Asp           
                750                 755                 760               

aaa gaa tat gtc tgt gta aaa tgt tgt gct gaa gaa gac aaa aag act       2357
Lys Glu Tyr Val Cys Val Lys Cys Cys Ala Glu Glu Asp Lys Lys Thr           
            765                 770                 775                   

gaa ata cta gat cca gat act ttg gaa aac caa gct aca gtt gaa ttc       2405
Glu Ile Leu Asp Pro Asp Thr Leu Glu Asn Gln Ala Thr Val Glu Phe           
        780                 785                 790                       

cat agt gga gat aaa aca atg gag tgt gaa aag ctt gga tta tca aaa       2453
His Ser Gly Asp Lys Thr Met Glu Cys Glu Lys Leu Gly Leu Ser Lys           
    795                 800                 805                           

cac aca aca aat gat aga acc aaa tat ata gat gat aca gtg aag cac       2501
His Thr Thr Asn Asp Arg Thr Lys Tyr Ile Asp Asp Thr Val Lys His           
810                 815                 820                 825           

aag gtc aaa att tta aaa cgg gag tct ggt gaa ggc aga aat tca tca       2549
Lys Val Lys Ile Leu Lys Arg Glu Ser Gly Glu Gly Arg Asn Ser Ser           
                830                 835                 840               

gac tgt aga gat aat gaa att aaa aaa tgg cag cta gct cct ctt cgt       2597
Asp Cys Arg Asp Asn Glu Ile Lys Lys Trp Gln Leu Ala Pro Leu Arg           
            845                 850                 855                   

aag atg gga caa cca gtt tta cct cgg aga tcc tca gaa gaa aaa agt       2645
Lys Met Gly Gln Pro Val Leu Pro Arg Arg Ser Ser Glu Glu Lys Ser           
        860                 865                 870                       

gaa aaa ata ccg aaa gag tct aca act gtt act tgc aca gga gaa aaa       2693
Glu Lys Ile Pro Lys Glu Ser Thr Thr Val Thr Cys Thr Gly Glu Lys           
    875                 880                 885                           

gct tca aaa cca ggt act cat gag aag caa gag atg aaa aag aag aaa       2741
Ala Ser Lys Pro Gly Thr His Glu Lys Gln Glu Met Lys Lys Lys Lys           
890                 895                 900                 905           

gtt gaa aaa gga gtg ctt aat gta cat cct gct gct tct gct tcc aag       2789
Val Glu Lys Gly Val Leu Asn Val His Pro Ala Ala Ser Ala Ser Lys           
                910                 915                 920               

cct tct gca gat cag atc agg caa agt gtc aga cat tct ctc aaa gac       2837
Pro Ser Ala Asp Gln Ile Arg Gln Ser Val Arg His Ser Leu Lys Asp           
            925                 930                 935                   

att ctt atg aag aga ctt aca gac tca aat ttg aag gta cca gag gaa       2885
Ile Leu Met Lys Arg Leu Thr Asp Ser Asn Leu Lys Val Pro Glu Glu           
        940                 945                 950                       

aag gca gca aaa gtt gcc aca aaa att gag aaa gag ctt ttc tct ttt       2933
Lys Ala Ala Lys Val Ala Thr Lys Ile Glu Lys Glu Leu Phe Ser Phe           
    955                 960                 965                           

ttt cgg gac aca gat gct aaa tat aag aac aaa tat aga agt ttg atg       2981
Phe Arg Asp Thr Asp Ala Lys Tyr Lys Asn Lys Tyr Arg Ser Leu Met           
970                 975                 980                 985           

ttt aat ttg aaa gat cct aaa aac aat ata tta ttt aaa aaa gta  ctg      3029
Phe Asn Leu Lys Asp Pro Lys Asn Asn Ile Leu Phe Lys Lys Val  Leu          
                990                 995                 1000              

aaa gga gaa gta  act cct gat cat ctt  atc aga atg agt cca  gaa        3074
Lys Gly Glu Val  Thr Pro Asp His Leu  Ile Arg Met Ser Pro  Glu            
            1005                 1010                 1015                

gaa cta gct tct  aaa gag tta gct gct  tgg aga cga aga gaa  aac        3119
Glu Leu Ala Ser  Lys Glu Leu Ala Ala  Trp Arg Arg Arg Glu  Asn            
            1020                 1025                 1030                

aga cat acc ata  gaa atg att gag aaa  gag cag aga gaa gtg  gaa        3164
Arg His Thr Ile  Glu Met Ile Glu Lys  Glu Gln Arg Glu Val  Glu            
            1035                 1040                 1045                

cga cgg cca atc  acc aaa ata act cat  aaa ggt gaa ata gaa  att        3209
Arg Arg Pro Ile  Thr Lys Ile Thr His  Lys Gly Glu Ile Glu  Ile            
            1050                 1055                 1060                

gag agt gat gcc  cca atg aaa gaa cag  gaa gca gcc atg gag  att        3254
Glu Ser Asp Ala  Pro Met Lys Glu Gln  Glu Ala Ala Met Glu  Ile            
            1065                 1070                 1075                

cag gaa cca gcc  gcc aat aag tca ttg  gag aag cca gaa gga  tct        3299
Gln Glu Pro Ala  Ala Asn Lys Ser Leu  Glu Lys Pro Glu Gly  Ser            
            1080                 1085                 1090                

gaa aaa caa aaa  gag gag gtt gac tct  atg tct aaa gat acc  act        3344
Glu Lys Gln Lys  Glu Glu Val Asp Ser  Met Ser Lys Asp Thr  Thr            
            1095                 1100                 1105                

agt caa cac aga  cag cat ctt ttt gat  ctc aac tgc aaa atc  tgc        3389
Ser Gln His Arg  Gln His Leu Phe Asp  Leu Asn Cys Lys Ile  Cys            
            1110                 1115                 1120                

ata ggt cga atg  gca cca cct gta gat  gat ctt tct cca aaa  aaa        3434
Ile Gly Arg Met  Ala Pro Pro Val Asp  Asp Leu Ser Pro Lys  Lys            
            1125                 1130                 1135                

gta aaa gtt gtt  gta gga gta gct cgc  aaa cat tca gac aat  gaa        3479
Val Lys Val Val  Val Gly Val Ala Arg  Lys His Ser Asp Asn  Glu            
            1140                 1145                 1150                

gca gaa agt ata  gca gat gca tta tct  tca acc tca aat att  ttg        3524
Ala Glu Ser Ile  Ala Asp Ala Leu Ser  Ser Thr Ser Asn Ile  Leu            
            1155                 1160                 1165                

gct tct gaa ttc  ttt gag gag gag aaa  cag gag tct cca aag  tca        3569
Ala Ser Glu Phe  Phe Glu Glu Glu Lys  Gln Glu Ser Pro Lys  Ser            
            1170                 1175                 1180                

acg ttc tct cct  gct cca cgt cca gag  atg cct gga act gtt  gaa        3614
Thr Phe Ser Pro  Ala Pro Arg Pro Glu  Met Pro Gly Thr Val  Glu            
            1185                 1190                 1195                

gtt gag tct acc  ttt ctg gct cga ttg  aac ttc atc tgg aaa  ggt        3659
Val Glu Ser Thr  Phe Leu Ala Arg Leu  Asn Phe Ile Trp Lys  Gly            
            1200                 1205                 1210                

ttt atc aac atg  cct tct gtg gca aaa  ttt gtt acc aaa gcc  tat        3704
Phe Ile Asn Met  Pro Ser Val Ala Lys  Phe Val Thr Lys Ala  Tyr            
            1215                 1220                 1225                

cca gta tct ggc  tcc cca gaa tac ctg  aca gag gac cta cca  gat        3749
Pro Val Ser Gly  Ser Pro Glu Tyr Leu  Thr Glu Asp Leu Pro  Asp            
            1230                 1235                 1240                

agt att caa gta  ggt ggc agg ata tca  cct cag aca gtt tgg  gat        3794
Ser Ile Gln Val  Gly Gly Arg Ile Ser  Pro Gln Thr Val Trp  Asp            
            1245                 1250                 1255                

tat gtg gaa aaa  ata aaa gca tca gga  acc aag gaa att tgt  gtg        3839
Tyr Val Glu Lys  Ile Lys Ala Ser Gly  Thr Lys Glu Ile Cys  Val            
            1260                 1265                 1270                

gtt cgc ttc aca  cca gta act gaa gaa  gat caa att tct tat  act        3884
Val Arg Phe Thr  Pro Val Thr Glu Glu  Asp Gln Ile Ser Tyr  Thr            
            1275                 1280                 1285                

ttg ctc ttt gca  tac ttc agt agc aga  aag cgc tat gga gta  gct        3929
Leu Leu Phe Ala  Tyr Phe Ser Ser Arg  Lys Arg Tyr Gly Val  Ala            
            1290                 1295                 1300                

gct aac aac atg  aag cag gtt aaa gat  atg tac ctt att cct  ttg        3974
Ala Asn Asn Met  Lys Gln Val Lys Asp  Met Tyr Leu Ile Pro  Leu            
            1305                 1310                 1315                

ggt gcc aca gat  aaa att cca cac cct  ctt gtg cct ttt gat  gga        4019
Gly Ala Thr Asp  Lys Ile Pro His Pro  Leu Val Pro Phe Asp  Gly            
            1320                 1325                 1330                

cct ggg ctt gaa  ctg cat aga cct aat  cta ttg ttg ggc tta  att        4064
Pro Gly Leu Glu  Leu His Arg Pro Asn  Leu Leu Leu Gly Leu  Ile            
            1335                 1340                 1345                

att cgt cag aaa  ctg aag cga cag cac  agt gcc tgt gct agt  act        4109
Ile Arg Gln Lys  Leu Lys Arg Gln His  Ser Ala Cys Ala Ser  Thr            
            1350                 1355                 1360                

agt cat ata gct  gag act cct gaa agt  gca cca cca ata gca  ttg        4154
Ser His Ile Ala  Glu Thr Pro Glu Ser  Ala Pro Pro Ile Ala  Leu            
            1365                 1370                 1375                

cca cct gat aaa  aaa agt aaa ata gaa  gtt tct aca gaa gaa  gca        4199
Pro Pro Asp Lys  Lys Ser Lys Ile Glu  Val Ser Thr Glu Glu  Ala            
            1380                 1385                 1390                

cca gag gaa gaa  aat gac ttt ttt aat  tct ttt aca act gta  tta        4244
Pro Glu Glu Glu  Asn Asp Phe Phe Asn  Ser Phe Thr Thr Val  Leu            
            1395                 1400                 1405                

cac aag cag aga  aat aaa cct cag cag  aat ctt cag gaa gac  ctt        4289
His Lys Gln Arg  Asn Lys Pro Gln Gln  Asn Leu Gln Glu Asp  Leu            
            1410                 1415                 1420                

cca aca gca gtt  gaa cct tta atg gaa  gtc acc aaa cag gag  cca        4334
Pro Thr Ala Val  Glu Pro Leu Met Glu  Val Thr Lys Gln Glu  Pro            
            1425                 1430                 1435                

cca aaa cct tta  aga ttt ctt cct ggc  gtg ttg att ggc tgg  gag        4379
Pro Lys Pro Leu  Arg Phe Leu Pro Gly  Val Leu Ile Gly Trp  Glu            
            1440                 1445                 1450                

aat caa cct act  act ctg gaa tta gca  aat aaa cct ctt cct  gtg        4424
Asn Gln Pro Thr  Thr Leu Glu Leu Ala  Asn Lys Pro Leu Pro  Val            
            1455                 1460                 1465                

gat gat ata ctt  caa agc ctt ttg ggc  acc act ggt caa gta  tat        4469
Asp Asp Ile Leu  Gln Ser Leu Leu Gly  Thr Thr Gly Gln Val  Tyr            
            1470                 1475                 1480                

gac cag gcc cag  tca gtg atg gaa caa  aac act gtt aaa gaa  att        4514
Asp Gln Ala Gln  Ser Val Met Glu Gln  Asn Thr Val Lys Glu  Ile            
            1485                 1490                 1495                

cca ttt tta aat  gag cag acc aac tca  aaa ata gag aaa aca  gat        4559
Pro Phe Leu Asn  Glu Gln Thr Asn Ser  Lys Ile Glu Lys Thr  Asp            
            1500                 1505                 1510                

aat gtg gaa gta  act gat ggt gaa aac  aag gag ata aaa gtt  aaa        4604
Asn Val Glu Val  Thr Asp Gly Glu Asn  Lys Glu Ile Lys Val  Lys            
            1515                 1520                 1525                

gta gat aat att  tca gaa tct aca gat  aag tca gca gaa ata  gaa        4649
Val Asp Asn Ile  Ser Glu Ser Thr Asp  Lys Ser Ala Glu Ile  Glu            
            1530                 1535                 1540                

aca tca gta gta  ggg tcc tct tcc att  tct gca ggg tct ttg  acg        4694
Thr Ser Val Val  Gly Ser Ser Ser Ile  Ser Ala Gly Ser Leu  Thr            
            1545                 1550                 1555                

agt ctt agt ctc  aga ggt aag cca cca  gat gtt tct aca gaa  gca        4739
Ser Leu Ser Leu  Arg Gly Lys Pro Pro  Asp Val Ser Thr Glu  Ala            
            1560                 1565                 1570                

ttt tta aca aat  tta tca att cag tca  aaa caa gag gaa act  gtg        4784
Phe Leu Thr Asn  Leu Ser Ile Gln Ser  Lys Gln Glu Glu Thr  Val            
            1575                 1580                 1585                

gag agt aaa gag  aaa aca tta aaa aga  cag ctt cag gaa gat  caa        4829
Glu Ser Lys Glu  Lys Thr Leu Lys Arg  Gln Leu Gln Glu Asp  Gln            
            1590                 1595                 1600                

gag aat aat ttg  caa gat aac cag act  tca aat agt tct cca  tgc        4874
Glu Asn Asn Leu  Gln Asp Asn Gln Thr  Ser Asn Ser Ser Pro  Cys            
            1605                 1610                 1615                

aga tct aat gta  gga aaa gga aac ata  gat ggt aat gtg agc  tgt        4919
Arg Ser Asn Val  Gly Lys Gly Asn Ile  Asp Gly Asn Val Ser  Cys            
            1620                 1625                 1630                

agt gaa aac ctt  gtt gct aat aca gcg  agg tct cca cag ttt  atc        4964
Ser Glu Asn Leu  Val Ala Asn Thr Ala  Arg Ser Pro Gln Phe  Ile            
            1635                 1640                 1645                

aac ctg aaa agg  gat cct agg caa gca  gca gga cga agt cag  cct        5009
Asn Leu Lys Arg  Asp Pro Arg Gln Ala  Ala Gly Arg Ser Gln  Pro            
            1650                 1655                 1660                

gta act act tca  gaa agc aaa gat gga  gat agt tgc cgg aat  gga        5054
Val Thr Thr Ser  Glu Ser Lys Asp Gly  Asp Ser Cys Arg Asn  Gly            
            1665                 1670                 1675                

gaa aaa cac atg  ctg cct ggc ctg tca  cac aac aag gag cac  tta        5099
Glu Lys His Met  Leu Pro Gly Leu Ser  His Asn Lys Glu His  Leu            
            1680                 1685                 1690                

aca gaa caa atc  aat gta gag gaa aag  ttg tgt tct gca gag  aaa        5144
Thr Glu Gln Ile  Asn Val Glu Glu Lys  Leu Cys Ser Ala Glu  Lys            
            1695                 1700                 1705                

aac tcg tgt gtt  cag cag agt gac aat  tta aaa gtt gca caa  aac        5189
Asn Ser Cys Val  Gln Gln Ser Asp Asn  Leu Lys Val Ala Gln  Asn            
            1710                 1715                 1720                

tca cca tca gta  gaa aac ata cag act  tct caa gca gaa caa  gca        5234
Ser Pro Ser Val  Glu Asn Ile Gln Thr  Ser Gln Ala Glu Gln  Ala            
            1725                 1730                 1735                

aaa ccc tta cag  gag gat att tta atg  caa aat att gaa act  gtg        5279
Lys Pro Leu Gln  Glu Asp Ile Leu Met  Gln Asn Ile Glu Thr  Val            
            1740                 1745                 1750                

cac cca ttt cga  aga gga tca gca gta  gcg aca tct cat ttt  gaa        5324
His Pro Phe Arg  Arg Gly Ser Ala Val  Ala Thr Ser His Phe  Glu            
            1755                 1760                 1765                

gtt gga aac aca  tgt cca tca gaa ttt  cct tct aaa agc atc  acc        5369
Val Gly Asn Thr  Cys Pro Ser Glu Phe  Pro Ser Lys Ser Ile  Thr            
            1770                 1775                 1780                

ttt act tcc aga  agc acc agc ccc aga  aca agt aca aac ttt  tca        5414
Phe Thr Ser Arg  Ser Thr Ser Pro Arg  Thr Ser Thr Asn Phe  Ser            
            1785                 1790                 1795                

ccc atg agg cca  cag cag ccc aac ctt  cag cat ctc aag tct  agc        5459
Pro Met Arg Pro  Gln Gln Pro Asn Leu  Gln His Leu Lys Ser  Ser            
            1800                 1805                 1810                

cca cct gga ttt  cca ttt cca ggg cct  cct aat ttt ccc cca  caa        5504
Pro Pro Gly Phe  Pro Phe Pro Gly Pro  Pro Asn Phe Pro Pro  Gln            
            1815                 1820                 1825                

agc atg ttt gga  ttt cca cca cat ttg  cca cct cca tta ctt  ccc        5549
Ser Met Phe Gly  Phe Pro Pro His Leu  Pro Pro Pro Leu Leu  Pro            
            1830                 1835                 1840                

cct cca ggc ttt  ggc ttt gct caa aat  ccc atg gtt ccc tgg  cca        5594
Pro Pro Gly Phe  Gly Phe Ala Gln Asn  Pro Met Val Pro Trp  Pro            
            1845                 1850                 1855                

cct gtt gtt cat  ctc cca ggt cag cca  cag cgt atg atg ggt  cct        5639
Pro Val Val His  Leu Pro Gly Gln Pro  Gln Arg Met Met Gly  Pro            
            1860                 1865                 1870                

ctc tca caa gca  tca agg tat ata ggc  ccg cag aat ttt tac  cag        5684
Leu Ser Gln Ala  Ser Arg Tyr Ile Gly  Pro Gln Asn Phe Tyr  Gln            
            1875                 1880                 1885                

gtt aaa gac att  cgg agg cca gaa agg  cgc cat agt gac cct  tgg        5729
Val Lys Asp Ile  Arg Arg Pro Glu Arg  Arg His Ser Asp Pro  Trp            
            1890                 1895                 1900                

ggt agg caa gac  caa cag caa ctg gat  agg cca ttt aat agg  ggt        5774
Gly Arg Gln Asp  Gln Gln Gln Leu Asp  Arg Pro Phe Asn Arg  Gly            
            1905                 1910                 1915                

aaa ggg gac cgc  cag aga ttt tat agt  gat tca cac cat ttg  aaa        5819
Lys Gly Asp Arg  Gln Arg Phe Tyr Ser  Asp Ser His His Leu  Lys            
            1920                 1925                 1930                

aga gag cga cat  gaa aag gaa tgg gag  caa gaa tct gaa agg  cat        5864
Arg Glu Arg His  Glu Lys Glu Trp Glu  Gln Glu Ser Glu Arg  His            
            1935                 1940                 1945                

aga cgc aga gac  aga agc caa gac aag  gac aga gac aga aaa  agc        5909
Arg Arg Arg Asp  Arg Ser Gln Asp Lys  Asp Arg Asp Arg Lys  Ser            
            1950                 1955                 1960                

agg gag gaa ggg  cac aaa gat aaa gag  agg gca cgg tta tca  cat        5954
Arg Glu Glu Gly  His Lys Asp Lys Glu  Arg Ala Arg Leu Ser  His            
            1965                 1970                 1975                

ggt gat cga gga  aca gat gga aaa gca  agc aga gat agt agg  aat        5999
Gly Asp Arg Gly  Thr Asp Gly Lys Ala  Ser Arg Asp Ser Arg  Asn            
            1980                 1985                 1990                

gta gac aag aag  cca gat aaa cct aaa  agt gaa gac tat gag  aag        6044
Val Asp Lys Lys  Pro Asp Lys Pro Lys  Ser Glu Asp Tyr Glu  Lys            
            1995                 2000                 2005                

gac aaa gaa cga  gag aaa agt aaa cac  aga gaa gga gaa aag  gac        6089
Asp Lys Glu Arg  Glu Lys Ser Lys His  Arg Glu Gly Glu Lys  Asp            
            2010                 2015                 2020                

agg gat agg tac  cac aaa gat agg gac  cac act gac aga act  aaa        6134
Arg Asp Arg Tyr  His Lys Asp Arg Asp  His Thr Asp Arg Thr  Lys            
            2025                 2030                 2035                

agc aaa agg taa aatttgcagg ctgcttcagg attacattta aataactgtt           6186
Ser Lys Arg                                                               
                                                                          

aaaatgttgt atcttgtaaa caaaagaaag attgcctgct aggattgtgc catctttaaa     6246

atttttacta ttggtcattt gcagaacagt aaattctgtg tgttggtaca gagtgctctg     6306

taccagtgct catcatccct tcttcatacc aacggtccct agttatagga atttaatatt     6366

tttaaaagtt ttacattgct gtatattcaa agatttgttt tattaatatg caataaaggc     6426

ttagaaattt tagttttatt ccttaattgg taaatatggt taactatgga atatatttac     6486

ttcctctagt gaatgtcctt tatataatga ctaatttggg agtaatgtgt gctctgtaag     6546

tttgttttaa attgcactgt ttttaaagaa actgtagagg agcaacaaaa atccaagcaa     6606

cttcataatc agattatgct aatcatttag ttgagcagtt tttgaccaag aatcagaagc     6666

ccaaggggta catttattgc tttaatctgc actcattgaa gtcatttatt accatatact     6726

acagctttgt ggtaggccat tattttcatt ttcatttttg gctcttcaga aacttgaata     6786

cttaagcttg tacatgatct tgtgttttgc tatccttttt actgtaaaat gtaaatattt     6846

taagggatat tttgattcta aatatgataa aataatttct cacctatttt gtgtgtgtga     6906

cttgaaattc agtagtaaaa gaatttcttc tttaaagctt t                         6947


<210>  170
<211>  2039
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Asp Ile Val Asp Thr Phe Asn His Leu Ile Pro Thr Glu His Leu 
1               5                   10                  15      


Asp Asp Ala Leu Phe Leu Gly Ser Asn Leu Glu Asn Glu Val Cys Glu 
            20                  25                  30          


Asp Phe Ser Ala Ser Gln Asn Val Leu Glu Asp Ser Leu Lys Asn Met 
        35                  40                  45              


Leu Ser Asp Lys Asp Pro Met Leu Gly Ser Ala Ser Asn Gln Phe Cys 
    50                  55                  60                  


Leu Pro Val Leu Asp Ser Asn Asp Pro Asn Phe Gln Met Pro Cys Ser 
65                  70                  75                  80  


Thr Val Val Gly Leu Asp Asp Ile Met Asp Glu Gly Val Val Lys Glu 
                85                  90                  95      


Ser Gly Asn Asp Thr Ile Asp Glu Glu Glu Leu Ile Leu Pro Asn Arg 
            100                 105                 110         


Asn Leu Arg Asp Lys Val Glu Glu Asn Ser Val Arg Ser Pro Arg Lys 
        115                 120                 125             


Ser Pro Arg Leu Met Ala Gln Glu Gln Val Arg Ser Leu Arg Gln Ser 
    130                 135                 140                 


Thr Ile Ala Lys Arg Ser Asn Ala Ala Pro Leu Ser Asn Thr Lys Lys 
145                 150                 155                 160 


Ala Ser Gly Lys Thr Val Ser Thr Ala Lys Ala Gly Val Lys Gln Pro 
                165                 170                 175     


Glu Arg Ser Gln Val Lys Glu Glu Val Cys Met Ser Leu Lys Pro Glu 
            180                 185                 190         


Tyr His Lys Glu Asn Arg Arg Cys Ser Arg Asn Ser Gly Gln Ile Glu 
        195                 200                 205             


Val Val Pro Glu Val Ser Val Ser Ser Ser His Ser Ser Val Ser Ser 
    210                 215                 220                 


Cys Leu Glu Met Lys Asp Glu Asp Gly Leu Asp Ser Lys His Lys Cys 
225                 230                 235                 240 


Asn Asn Pro Gly Glu Ile Asp Val Pro Ser His Glu Leu Asn Cys Ser 
                245                 250                 255     


Leu Leu Ser Glu Thr Cys Val Thr Ile Gly Glu Lys Lys Asn Glu Ala 
            260                 265                 270         


Leu Met Glu Cys Lys Ala Lys Pro Val Gly Ser Pro Leu Phe Lys Phe 
        275                 280                 285             


Ser Asp Lys Glu Glu His Glu Gln Asn Asp Ser Ile Ser Gly Lys Thr 
    290                 295                 300                 


Gly Glu Thr Val Val Glu Glu Met Ile Ala Thr Arg Lys Val Glu Gln 
305                 310                 315                 320 


Asp Ser Lys Glu Thr Val Lys Leu Ser His Glu Asp Asp His Ile Leu 
                325                 330                 335     


Glu Asp Ala Gly Ser Ser Asp Ile Ser Ser Asp Ala Ala Cys Thr Asn 
            340                 345                 350         


Pro Asn Lys Thr Glu Asn Ser Leu Val Gly Leu Pro Ser Cys Val Asp 
        355                 360                 365             


Glu Val Thr Glu Cys Asn Leu Glu Leu Lys Asp Thr Met Gly Ile Ala 
    370                 375                 380                 


Asp Lys Thr Glu Asn Thr Leu Glu Arg Asn Lys Ile Glu Pro Leu Gly 
385                 390                 395                 400 


Tyr Cys Glu Asp Ala Glu Ser Asn Arg Gln Leu Glu Ser Thr Glu Phe 
                405                 410                 415     


Asn Lys Ser Asn Leu Glu Val Val Asp Thr Ser Thr Phe Gly Pro Glu 
            420                 425                 430         


Ser Asn Ile Leu Glu Asn Ala Ile Cys Asp Val Pro Asp Gln Asn Ser 
        435                 440                 445             


Lys Gln Leu Asn Ala Ile Glu Ser Thr Lys Ile Glu Ser His Glu Thr 
    450                 455                 460                 


Ala Asn Leu Gln Asp Asp Arg Asn Ser Gln Ser Ser Ser Val Ser Tyr 
465                 470                 475                 480 


Leu Glu Ser Lys Ser Val Lys Ser Lys His Thr Lys Pro Val Ile His 
                485                 490                 495     


Ser Lys Gln Asn Met Thr Thr Asp Ala Pro Lys Lys Ile Val Ala Ala 
            500                 505                 510         


Lys Tyr Glu Val Ile His Ser Lys Thr Lys Val Asn Val Lys Ser Val 
        515                 520                 525             


Lys Arg Asn Thr Asp Val Pro Glu Ser Gln Gln Asn Phe His Arg Pro 
    530                 535                 540                 


Val Lys Val Arg Lys Lys Gln Ile Asp Lys Glu Pro Lys Ile Gln Ser 
545                 550                 555                 560 


Cys Asn Ser Gly Val Lys Ser Val Lys Asn Gln Ala His Ser Val Leu 
                565                 570                 575     


Lys Lys Thr Leu Gln Asp Gln Thr Leu Val Gln Ile Phe Lys Pro Leu 
            580                 585                 590         


Thr His Ser Leu Ser Asp Lys Ser His Ala His Pro Gly Cys Leu Lys 
        595                 600                 605             


Glu Pro His His Pro Ala Gln Thr Gly His Val Ser His Ser Ser Gln 
    610                 615                 620                 


Lys Gln Cys His Lys Pro Gln Gln Gln Ala Pro Ala Met Lys Thr Asn 
625                 630                 635                 640 


Ser His Val Lys Glu Glu Leu Glu His Pro Gly Val Glu His Phe Lys 
                645                 650                 655     


Glu Glu Asp Lys Leu Lys Leu Lys Lys Pro Glu Lys Asn Leu Gln Pro 
            660                 665                 670         


Arg Gln Arg Arg Ser Ser Lys Ser Phe Ser Leu Asp Glu Pro Pro Leu 
        675                 680                 685             


Phe Ile Pro Asp Asn Ile Ala Thr Ile Arg Arg Glu Gly Ser Asp His 
    690                 695                 700                 


Ser Ser Ser Phe Glu Ser Lys Tyr Met Trp Thr Pro Ser Lys Gln Cys 
705                 710                 715                 720 


Gly Phe Cys Lys Lys Pro His Gly Asn Arg Phe Met Val Gly Cys Gly 
                725                 730                 735     


Arg Cys Asp Asp Trp Phe His Gly Asp Cys Val Gly Leu Ser Leu Ser 
            740                 745                 750         


Gln Ala Gln Gln Met Gly Glu Glu Asp Lys Glu Tyr Val Cys Val Lys 
        755                 760                 765             


Cys Cys Ala Glu Glu Asp Lys Lys Thr Glu Ile Leu Asp Pro Asp Thr 
    770                 775                 780                 


Leu Glu Asn Gln Ala Thr Val Glu Phe His Ser Gly Asp Lys Thr Met 
785                 790                 795                 800 


Glu Cys Glu Lys Leu Gly Leu Ser Lys His Thr Thr Asn Asp Arg Thr 
                805                 810                 815     


Lys Tyr Ile Asp Asp Thr Val Lys His Lys Val Lys Ile Leu Lys Arg 
            820                 825                 830         


Glu Ser Gly Glu Gly Arg Asn Ser Ser Asp Cys Arg Asp Asn Glu Ile 
        835                 840                 845             


Lys Lys Trp Gln Leu Ala Pro Leu Arg Lys Met Gly Gln Pro Val Leu 
    850                 855                 860                 


Pro Arg Arg Ser Ser Glu Glu Lys Ser Glu Lys Ile Pro Lys Glu Ser 
865                 870                 875                 880 


Thr Thr Val Thr Cys Thr Gly Glu Lys Ala Ser Lys Pro Gly Thr His 
                885                 890                 895     


Glu Lys Gln Glu Met Lys Lys Lys Lys Val Glu Lys Gly Val Leu Asn 
            900                 905                 910         


Val His Pro Ala Ala Ser Ala Ser Lys Pro Ser Ala Asp Gln Ile Arg 
        915                 920                 925             


Gln Ser Val Arg His Ser Leu Lys Asp Ile Leu Met Lys Arg Leu Thr 
    930                 935                 940                 


Asp Ser Asn Leu Lys Val Pro Glu Glu Lys Ala Ala Lys Val Ala Thr 
945                 950                 955                 960 


Lys Ile Glu Lys Glu Leu Phe Ser Phe Phe Arg Asp Thr Asp Ala Lys 
                965                 970                 975     


Tyr Lys Asn Lys Tyr Arg Ser Leu Met Phe Asn Leu Lys Asp Pro Lys 
            980                 985                 990         


Asn Asn Ile Leu Phe Lys Lys Val  Leu Lys Gly Glu Val  Thr Pro Asp 
        995                 1000                 1005             


His Leu  Ile Arg Met Ser Pro  Glu Glu Leu Ala Ser  Lys Glu Leu 
    1010                 1015                 1020             


Ala Ala  Trp Arg Arg Arg Glu  Asn Arg His Thr Ile  Glu Met Ile 
    1025                 1030                 1035             


Glu Lys  Glu Gln Arg Glu Val  Glu Arg Arg Pro Ile  Thr Lys Ile 
    1040                 1045                 1050             


Thr His  Lys Gly Glu Ile Glu  Ile Glu Ser Asp Ala  Pro Met Lys 
    1055                 1060                 1065             


Glu Gln  Glu Ala Ala Met Glu  Ile Gln Glu Pro Ala  Ala Asn Lys 
    1070                 1075                 1080             


Ser Leu  Glu Lys Pro Glu Gly  Ser Glu Lys Gln Lys  Glu Glu Val 
    1085                 1090                 1095             


Asp Ser  Met Ser Lys Asp Thr  Thr Ser Gln His Arg  Gln His Leu 
    1100                 1105                 1110             


Phe Asp  Leu Asn Cys Lys Ile  Cys Ile Gly Arg Met  Ala Pro Pro 
    1115                 1120                 1125             


Val Asp  Asp Leu Ser Pro Lys  Lys Val Lys Val Val  Val Gly Val 
    1130                 1135                 1140             


Ala Arg  Lys His Ser Asp Asn  Glu Ala Glu Ser Ile  Ala Asp Ala 
    1145                 1150                 1155             


Leu Ser  Ser Thr Ser Asn Ile  Leu Ala Ser Glu Phe  Phe Glu Glu 
    1160                 1165                 1170             


Glu Lys  Gln Glu Ser Pro Lys  Ser Thr Phe Ser Pro  Ala Pro Arg 
    1175                 1180                 1185             


Pro Glu  Met Pro Gly Thr Val  Glu Val Glu Ser Thr  Phe Leu Ala 
    1190                 1195                 1200             


Arg Leu  Asn Phe Ile Trp Lys  Gly Phe Ile Asn Met  Pro Ser Val 
    1205                 1210                 1215             


Ala Lys  Phe Val Thr Lys Ala  Tyr Pro Val Ser Gly  Ser Pro Glu 
    1220                 1225                 1230             


Tyr Leu  Thr Glu Asp Leu Pro  Asp Ser Ile Gln Val  Gly Gly Arg 
    1235                 1240                 1245             


Ile Ser  Pro Gln Thr Val Trp  Asp Tyr Val Glu Lys  Ile Lys Ala 
    1250                 1255                 1260             


Ser Gly  Thr Lys Glu Ile Cys  Val Val Arg Phe Thr  Pro Val Thr 
    1265                 1270                 1275             


Glu Glu  Asp Gln Ile Ser Tyr  Thr Leu Leu Phe Ala  Tyr Phe Ser 
    1280                 1285                 1290             


Ser Arg  Lys Arg Tyr Gly Val  Ala Ala Asn Asn Met  Lys Gln Val 
    1295                 1300                 1305             


Lys Asp  Met Tyr Leu Ile Pro  Leu Gly Ala Thr Asp  Lys Ile Pro 
    1310                 1315                 1320             


His Pro  Leu Val Pro Phe Asp  Gly Pro Gly Leu Glu  Leu His Arg 
    1325                 1330                 1335             


Pro Asn  Leu Leu Leu Gly Leu  Ile Ile Arg Gln Lys  Leu Lys Arg 
    1340                 1345                 1350             


Gln His  Ser Ala Cys Ala Ser  Thr Ser His Ile Ala  Glu Thr Pro 
    1355                 1360                 1365             


Glu Ser  Ala Pro Pro Ile Ala  Leu Pro Pro Asp Lys  Lys Ser Lys 
    1370                 1375                 1380             


Ile Glu  Val Ser Thr Glu Glu  Ala Pro Glu Glu Glu  Asn Asp Phe 
    1385                 1390                 1395             


Phe Asn  Ser Phe Thr Thr Val  Leu His Lys Gln Arg  Asn Lys Pro 
    1400                 1405                 1410             


Gln Gln  Asn Leu Gln Glu Asp  Leu Pro Thr Ala Val  Glu Pro Leu 
    1415                 1420                 1425             


Met Glu  Val Thr Lys Gln Glu  Pro Pro Lys Pro Leu  Arg Phe Leu 
    1430                 1435                 1440             


Pro Gly  Val Leu Ile Gly Trp  Glu Asn Gln Pro Thr  Thr Leu Glu 
    1445                 1450                 1455             


Leu Ala  Asn Lys Pro Leu Pro  Val Asp Asp Ile Leu  Gln Ser Leu 
    1460                 1465                 1470             


Leu Gly  Thr Thr Gly Gln Val  Tyr Asp Gln Ala Gln  Ser Val Met 
    1475                 1480                 1485             


Glu Gln  Asn Thr Val Lys Glu  Ile Pro Phe Leu Asn  Glu Gln Thr 
    1490                 1495                 1500             


Asn Ser  Lys Ile Glu Lys Thr  Asp Asn Val Glu Val  Thr Asp Gly 
    1505                 1510                 1515             


Glu Asn  Lys Glu Ile Lys Val  Lys Val Asp Asn Ile  Ser Glu Ser 
    1520                 1525                 1530             


Thr Asp  Lys Ser Ala Glu Ile  Glu Thr Ser Val Val  Gly Ser Ser 
    1535                 1540                 1545             


Ser Ile  Ser Ala Gly Ser Leu  Thr Ser Leu Ser Leu  Arg Gly Lys 
    1550                 1555                 1560             


Pro Pro  Asp Val Ser Thr Glu  Ala Phe Leu Thr Asn  Leu Ser Ile 
    1565                 1570                 1575             


Gln Ser  Lys Gln Glu Glu Thr  Val Glu Ser Lys Glu  Lys Thr Leu 
    1580                 1585                 1590             


Lys Arg  Gln Leu Gln Glu Asp  Gln Glu Asn Asn Leu  Gln Asp Asn 
    1595                 1600                 1605             


Gln Thr  Ser Asn Ser Ser Pro  Cys Arg Ser Asn Val  Gly Lys Gly 
    1610                 1615                 1620             


Asn Ile  Asp Gly Asn Val Ser  Cys Ser Glu Asn Leu  Val Ala Asn 
    1625                 1630                 1635             


Thr Ala  Arg Ser Pro Gln Phe  Ile Asn Leu Lys Arg  Asp Pro Arg 
    1640                 1645                 1650             


Gln Ala  Ala Gly Arg Ser Gln  Pro Val Thr Thr Ser  Glu Ser Lys 
    1655                 1660                 1665             


Asp Gly  Asp Ser Cys Arg Asn  Gly Glu Lys His Met  Leu Pro Gly 
    1670                 1675                 1680             


Leu Ser  His Asn Lys Glu His  Leu Thr Glu Gln Ile  Asn Val Glu 
    1685                 1690                 1695             


Glu Lys  Leu Cys Ser Ala Glu  Lys Asn Ser Cys Val  Gln Gln Ser 
    1700                 1705                 1710             


Asp Asn  Leu Lys Val Ala Gln  Asn Ser Pro Ser Val  Glu Asn Ile 
    1715                 1720                 1725             


Gln Thr  Ser Gln Ala Glu Gln  Ala Lys Pro Leu Gln  Glu Asp Ile 
    1730                 1735                 1740             


Leu Met  Gln Asn Ile Glu Thr  Val His Pro Phe Arg  Arg Gly Ser 
    1745                 1750                 1755             


Ala Val  Ala Thr Ser His Phe  Glu Val Gly Asn Thr  Cys Pro Ser 
    1760                 1765                 1770             


Glu Phe  Pro Ser Lys Ser Ile  Thr Phe Thr Ser Arg  Ser Thr Ser 
    1775                 1780                 1785             


Pro Arg  Thr Ser Thr Asn Phe  Ser Pro Met Arg Pro  Gln Gln Pro 
    1790                 1795                 1800             


Asn Leu  Gln His Leu Lys Ser  Ser Pro Pro Gly Phe  Pro Phe Pro 
    1805                 1810                 1815             


Gly Pro  Pro Asn Phe Pro Pro  Gln Ser Met Phe Gly  Phe Pro Pro 
    1820                 1825                 1830             


His Leu  Pro Pro Pro Leu Leu  Pro Pro Pro Gly Phe  Gly Phe Ala 
    1835                 1840                 1845             


Gln Asn  Pro Met Val Pro Trp  Pro Pro Val Val His  Leu Pro Gly 
    1850                 1855                 1860             


Gln Pro  Gln Arg Met Met Gly  Pro Leu Ser Gln Ala  Ser Arg Tyr 
    1865                 1870                 1875             


Ile Gly  Pro Gln Asn Phe Tyr  Gln Val Lys Asp Ile  Arg Arg Pro 
    1880                 1885                 1890             


Glu Arg  Arg His Ser Asp Pro  Trp Gly Arg Gln Asp  Gln Gln Gln 
    1895                 1900                 1905             


Leu Asp  Arg Pro Phe Asn Arg  Gly Lys Gly Asp Arg  Gln Arg Phe 
    1910                 1915                 1920             


Tyr Ser  Asp Ser His His Leu  Lys Arg Glu Arg His  Glu Lys Glu 
    1925                 1930                 1935             


Trp Glu  Gln Glu Ser Glu Arg  His Arg Arg Arg Asp  Arg Ser Gln 
    1940                 1945                 1950             


Asp Lys  Asp Arg Asp Arg Lys  Ser Arg Glu Glu Gly  His Lys Asp 
    1955                 1960                 1965             


Lys Glu  Arg Ala Arg Leu Ser  His Gly Asp Arg Gly  Thr Asp Gly 
    1970                 1975                 1980             


Lys Ala  Ser Arg Asp Ser Arg  Asn Val Asp Lys Lys  Pro Asp Lys 
    1985                 1990                 1995             


Pro Lys  Ser Glu Asp Tyr Glu  Lys Asp Lys Glu Arg  Glu Lys Ser 
    2000                 2005                 2010             


Lys His  Arg Glu Gly Glu Lys  Asp Arg Asp Arg Tyr  His Lys Asp 
    2015                 2020                 2025             


Arg Asp  His Thr Asp Arg Thr  Lys Ser Lys Arg 
    2030                 2035                 


<210>  171
<211>  1290
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (628)..(1023)

<400>  171
ttagggtaga agaaaaggtt ttatttttct ttctcacatt ggaaaaaatg aaaactttcg       60

gacccatgaa attttattac attttgccaa aaacagaacc aataacataa gtattcaaag      120

ttatgtaaag ataattattt aatatgaaca ttatgatggt gagagggacc acggagcaag      180

gggctgcctt gcaggcctgc cttccagctt tgctacaggg accagaagcg ggagctgagc      240

gcaggggagg caggcggagg ccatgggcag cgaggcgggt gcgccaaagg gcgccagttc      300

cggagctgct gggcctgggc tgcaggaggg cggagctggg gccgcaaggc tggtgccggc      360

cgacaaacga cgcggcgcgg gcgagtgggc ggaggcggct gcggggaagg ctgggctgcc      420

gcgggacgcg gtgaagatag cctgcggagt gtccgggctg aacacggttg cagcactccc      480

agtagaccag gagctccggg aggcagggcc ggccccacgt cctctgcgca ccaccctgag      540

ttggatcctc tgtgcgccac ctgagttgga tccagggcta gctgctgttg acctccccac      600

tcccacgctg ccctcctgcc tgcagcc atg acg ccc ctg ctc acc ctg atc ctg      654
                              Met Thr Pro Leu Leu Thr Leu Ile Leu         
                              1               5                           

gtg gtc ctc atg ggc tta cct ctg gcc cag gcc ttg gac tgc cac gtg        702
Val Val Leu Met Gly Leu Pro Leu Ala Gln Ala Leu Asp Cys His Val           
10                  15                  20                  25            

tgt gcc tac aac gga gac aac tgc ttc aac ccc atg cgc tgc ccg gct        750
Cys Ala Tyr Asn Gly Asp Asn Cys Phe Asn Pro Met Arg Cys Pro Ala           
                30                  35                  40                

atg gtt gcc tac tgc atg acc acg cgc acc tct gca gcc gaa gcc ata        798
Met Val Ala Tyr Cys Met Thr Thr Arg Thr Ser Ala Ala Glu Ala Ile           
            45                  50                  55                    

tgg tgt cac cag tgc acg ggc ttc gga ggg tgc tcc cat gga tcc aga        846
Trp Cys His Gln Cys Thr Gly Phe Gly Gly Cys Ser His Gly Ser Arg           
        60                  65                  70                        

tgc ctg agg gac tcc acc cac tgt gtc acc act gcc acc cgg gtc ctc        894
Cys Leu Arg Asp Ser Thr His Cys Val Thr Thr Ala Thr Arg Val Leu           
    75                  80                  85                            

agc aac acc gag gat ttg cct ctg gtc acc aag atg tgc cac ata ggc        942
Ser Asn Thr Glu Asp Leu Pro Leu Val Thr Lys Met Cys His Ile Gly           
90                  95                  100                 105           

tgc ccc gat atc ccc agc ctg ggc ctg ggc ccc tac gta tcc atc gct        990
Cys Pro Asp Ile Pro Ser Leu Gly Leu Gly Pro Tyr Val Ser Ile Ala           
                110                 115                 120               

tgc tgc cag acc agc ctc tgc aac cat gac tga cggctgccct cctccaggcc     1043
Cys Cys Gln Thr Ser Leu Cys Asn His Asp                                   
            125                 130                                       

cccggacgct cagcccccac agcccccaca gcctggcgcc agggctcaca gctgcccctc     1103

cctcgagact ggccagccca cctctcccgg cctctgcagc caccgtccag caccgcttgt     1163

cctagggaag tcctgcgtgg agtcttgcct caatctgctg ccgtccaagc ctggggccca     1223

tcgtgcctgc cgccccttca ggtcccgacc tccccacaat aaaatgtgat tggatcgtgt     1283

ggtacaa                                                               1290


<210>  172
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Thr Pro Leu Leu Thr Leu Ile Leu Val Val Leu Met Gly Leu Pro 
1               5                   10                  15      


Leu Ala Gln Ala Leu Asp Cys His Val Cys Ala Tyr Asn Gly Asp Asn 
            20                  25                  30          


Cys Phe Asn Pro Met Arg Cys Pro Ala Met Val Ala Tyr Cys Met Thr 
        35                  40                  45              


Thr Arg Thr Ser Ala Ala Glu Ala Ile Trp Cys His Gln Cys Thr Gly 
    50                  55                  60                  


Phe Gly Gly Cys Ser His Gly Ser Arg Cys Leu Arg Asp Ser Thr His 
65                  70                  75                  80  


Cys Val Thr Thr Ala Thr Arg Val Leu Ser Asn Thr Glu Asp Leu Pro 
                85                  90                  95      


Leu Val Thr Lys Met Cys His Ile Gly Cys Pro Asp Ile Pro Ser Leu 
            100                 105                 110         


Gly Leu Gly Pro Tyr Val Ser Ile Ala Cys Cys Gln Thr Ser Leu Cys 
        115                 120                 125             


Asn His Asp 
    130     


<210>  173
<211>  2802
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (250)..(2343)

<400>  173
ggaaacgaca ttcggagctg cgctcccgcc caggccggcc ctgacgcggg cctcgtcagc       60

cagtaacagg gagcagaggt gggagttagc gaggcgacca cgaaaacggt gaaggtcgga      120

accgacagcc tcctccgaga agggcaggag ctgggaggag gcggcagcgg cggcggcaga      180

aacagcagcg gcggcggcgg cggcagctgg gaggaggtgg tgacggtggc aacggcagcg      240

tcggggacg atg gcg cga ctc gtg gca gtg tgc agg gac ggg gag gag gag      291
          Met Ala Arg Leu Val Ala Val Cys Arg Asp Gly Glu Glu Glu         
          1               5                   10                          

ttc ccc ttc gag agg agg cag att ccc ctc tac ata gac gac acc ctg        339
Phe Pro Phe Glu Arg Arg Gln Ile Pro Leu Tyr Ile Asp Asp Thr Leu           
15                  20                  25                  30            

acg atg gtg atg gaa ttt cct gat aat gtg tta aat ctc gat gga cat        387
Thr Met Val Met Glu Phe Pro Asp Asn Val Leu Asn Leu Asp Gly His           
                35                  40                  45                

cag aat aat ggt gca cag cta aag cag ttc att cag cga cat ggt atg        435
Gln Asn Asn Gly Ala Gln Leu Lys Gln Phe Ile Gln Arg His Gly Met           
            50                  55                  60                    

ctt aag caa cag gat cta agt att gcc atg gtg gtg aca tca cgc gaa        483
Leu Lys Gln Gln Asp Leu Ser Ile Ala Met Val Val Thr Ser Arg Glu           
        65                  70                  75                        

gtc ctg agt gca ctt tct cag ctt gtc cca tgt gtt ggt tgt cgt cgc        531
Val Leu Ser Ala Leu Ser Gln Leu Val Pro Cys Val Gly Cys Arg Arg           
    80                  85                  90                            

agt gtg gag cgt ctc ttt tcc cag ctt gta gag tct gga aat cct gct        579
Ser Val Glu Arg Leu Phe Ser Gln Leu Val Glu Ser Gly Asn Pro Ala           
95                  100                 105                 110           

ctt gaa ccc cta aca gta ggg ccc aag gga gtc ctg tct gta act aga        627
Leu Glu Pro Leu Thr Val Gly Pro Lys Gly Val Leu Ser Val Thr Arg           
                115                 120                 125               

agc tgc atg act gat gca aag aag ctt tat aca tta ttt tat gta cat        675
Ser Cys Met Thr Asp Ala Lys Lys Leu Tyr Thr Leu Phe Tyr Val His           
            130                 135                 140                   

ggg tcc aaa cta aat gac atg ata gat gct att cca aaa agt aag aag        723
Gly Ser Lys Leu Asn Asp Met Ile Asp Ala Ile Pro Lys Ser Lys Lys           
        145                 150                 155                       

aat aag aga tgt cag ttg cac tcc tta gat acg cac aag cca aaa cct        771
Asn Lys Arg Cys Gln Leu His Ser Leu Asp Thr His Lys Pro Lys Pro           
    160                 165                 170                           

ttg gga ggt tgt tgg atg gat gta tgg gaa cta atg tcg cag gaa tgc        819
Leu Gly Gly Cys Trp Met Asp Val Trp Glu Leu Met Ser Gln Glu Cys           
175                 180                 185                 190           

agg gat gaa gta gtt tta att gac tcg agt tgt ctt tta gaa aca cta        867
Arg Asp Glu Val Val Leu Ile Asp Ser Ser Cys Leu Leu Glu Thr Leu           
                195                 200                 205               

gaa aca tat ctg cga aaa cac agg ttt tgc act gat tgc aaa aat aaa        915
Glu Thr Tyr Leu Arg Lys His Arg Phe Cys Thr Asp Cys Lys Asn Lys           
            210                 215                 220                   

gtc ctc cga gca tac aat atc ctt att ggt gaa ctt gac tgc agc aaa        963
Val Leu Arg Ala Tyr Asn Ile Leu Ile Gly Glu Leu Asp Cys Ser Lys           
        225                 230                 235                       

gaa aag ggc tac tgt gct gca ctt tat gaa ggc ttg cgg tgc tgt cca       1011
Glu Lys Gly Tyr Cys Ala Ala Leu Tyr Glu Gly Leu Arg Cys Cys Pro           
    240                 245                 250                           

cat gaa cga cac ata cat gtt tgc tgt gaa aca gac ttc att gca cat       1059
His Glu Arg His Ile His Val Cys Cys Glu Thr Asp Phe Ile Ala His           
255                 260                 265                 270           

ctt ttg ggt cgt gct gag cca gag ttc gca gga ggg cga aga gaa agg       1107
Leu Leu Gly Arg Ala Glu Pro Glu Phe Ala Gly Gly Arg Arg Glu Arg           
                275                 280                 285               

cat gca aag aca ata gat ata gct caa gaa gaa gtt ctg acc tgc ttg       1155
His Ala Lys Thr Ile Asp Ile Ala Gln Glu Glu Val Leu Thr Cys Leu           
            290                 295                 300                   

gga att cat ctt tat gaa aga ctg cat cga atc tgg cag aag cta cgg       1203
Gly Ile His Leu Tyr Glu Arg Leu His Arg Ile Trp Gln Lys Leu Arg           
        305                 310                 315                       

gca gaa gag cag aca tgg cag atg ctt ttc tat ctt ggt gtt gat gct       1251
Ala Glu Glu Gln Thr Trp Gln Met Leu Phe Tyr Leu Gly Val Asp Ala           
    320                 325                 330                           

tta cgc aag agt ttt gag atg acc gtg gaa aaa gta cag ggt att agc       1299
Leu Arg Lys Ser Phe Glu Met Thr Val Glu Lys Val Gln Gly Ile Ser           
335                 340                 345                 350           

aga ttg gaa caa ctt tgt gag gaa ttt tca gaa gag gaa cga gta aga       1347
Arg Leu Glu Gln Leu Cys Glu Glu Phe Ser Glu Glu Glu Arg Val Arg           
                355                 360                 365               

gaa ctc aag caa gaa aag aaa cgc caa aaa cgg aag aat aga cga aaa       1395
Glu Leu Lys Gln Glu Lys Lys Arg Gln Lys Arg Lys Asn Arg Arg Lys           
            370                 375                 380                   

aat aag tgt gtg tgt gat att cct act ccc tta caa aca gca gat gaa       1443
Asn Lys Cys Val Cys Asp Ile Pro Thr Pro Leu Gln Thr Ala Asp Glu           
        385                 390                 395                       

aag gaa gta agc caa gag aag gaa aca gac ttc ata gaa aat agc agc       1491
Lys Glu Val Ser Gln Glu Lys Glu Thr Asp Phe Ile Glu Asn Ser Ser           
    400                 405                 410                           

tgc aaa gcc tgt ggc agc act gaa gat ggt aat act tgt gta gaa gta       1539
Cys Lys Ala Cys Gly Ser Thr Glu Asp Gly Asn Thr Cys Val Glu Val           
415                 420                 425                 430           

att gtt acc aat gaa aat aca tca tgt acc tgt cct agc agt ggc aat       1587
Ile Val Thr Asn Glu Asn Thr Ser Cys Thr Cys Pro Ser Ser Gly Asn           
                435                 440                 445               

ctt ttg ggg tcc cct aaa ata aag aaa ggc tta tct cca cac tgt aat       1635
Leu Leu Gly Ser Pro Lys Ile Lys Lys Gly Leu Ser Pro His Cys Asn           
            450                 455                 460                   

ggt agt gat tgt gga tat tca tct agc atg gaa ggg agt gaa aca ggt       1683
Gly Ser Asp Cys Gly Tyr Ser Ser Ser Met Glu Gly Ser Glu Thr Gly           
        465                 470                 475                       

tct cgg gag ggt tcg gat gtt gcc tgc act gaa ggc att tgt aat cat       1731
Ser Arg Glu Gly Ser Asp Val Ala Cys Thr Glu Gly Ile Cys Asn His           
    480                 485                 490                           

gat gaa cac ggt gat gac tct tgt gtt cat cac tgt gaa gac aaa gag       1779
Asp Glu His Gly Asp Asp Ser Cys Val His His Cys Glu Asp Lys Glu           
495                 500                 505                 510           

gat gat ggt gat agt tgt gtt gaa tgt tgg gca aat tct gaa gag aac       1827
Asp Asp Gly Asp Ser Cys Val Glu Cys Trp Ala Asn Ser Glu Glu Asn           
                515                 520                 525               

gac aca aaa gga aaa aat aaa aag aag aag aag aaa agc aag ata ctg       1875
Asp Thr Lys Gly Lys Asn Lys Lys Lys Lys Lys Lys Ser Lys Ile Leu           
            530                 535                 540                   

aaa tgt gat gaa cat atc cag aag ctt gga agc tgt att aca gat cca       1923
Lys Cys Asp Glu His Ile Gln Lys Leu Gly Ser Cys Ile Thr Asp Pro           
        545                 550                 555                       

ggt aat cga gag acc tca gga aat acc atg cac aca gtg ttt cac cgt       1971
Gly Asn Arg Glu Thr Ser Gly Asn Thr Met His Thr Val Phe His Arg           
    560                 565                 570                           

gac aag acc aaa gat aca cat cct gaa agc tgt tgc agc tct gaa aag       2019
Asp Lys Thr Lys Asp Thr His Pro Glu Ser Cys Cys Ser Ser Glu Lys           
575                 580                 585                 590           

ggt ggg cag cca ttg cct tgg ttt gag cat agg aaa aat gta cca cag       2067
Gly Gly Gln Pro Leu Pro Trp Phe Glu His Arg Lys Asn Val Pro Gln           
                595                 600                 605               

ttt gca gaa cct aca gaa acg ttg ttt ggt ccc gat tcc gga aaa ggt       2115
Phe Ala Glu Pro Thr Glu Thr Leu Phe Gly Pro Asp Ser Gly Lys Gly           
            610                 615                 620                   

gcc aag agc tta gtt gaa ctc ctt gat gag tct gaa tgt act tca gat       2163
Ala Lys Ser Leu Val Glu Leu Leu Asp Glu Ser Glu Cys Thr Ser Asp           
        625                 630                 635                       

gag gaa atc ttt atc tca caa gat gaa ata cag tca ttt atg gct aat       2211
Glu Glu Ile Phe Ile Ser Gln Asp Glu Ile Gln Ser Phe Met Ala Asn           
    640                 645                 650                           

aac cag tct ttc tac agc aat aga gaa caa tac cga cag cat ctg aag       2259
Asn Gln Ser Phe Tyr Ser Asn Arg Glu Gln Tyr Arg Gln His Leu Lys           
655                 660                 665                 670           

gag aaa ttt aat aaa tac tgc cgg tta aat gat cac aag agg ccc att       2307
Glu Lys Phe Asn Lys Tyr Cys Arg Leu Asn Asp His Lys Arg Pro Ile           
                675                 680                 685               

tgt agt ggc tgg ttg aca acg gct gga gca aat taa ataaataaaa            2353
Cys Ser Gly Trp Leu Thr Thr Ala Gly Ala Asn                               
            690                 695                                       

tagctctgtc tttcaatgaa acactcacga tgactactgc gccttctctt tcgaaaaact     2413

cttaatttag tgacttatgg caaaatttta tcttaaatca atgtgattct ttcttgtttt     2473

gggagacggt ggaggtatcc tcattagttc tttcttcagg cttgtgtctt tagttgcgtg     2533

gctgcgcagg cctgccatat gatttaagcc atctcttttc attaaatgtt tctcttcctg     2593

tgagacttac taaagcaact tagtggcaaa aagtaatgtt gtacttataa ttctgtacag     2653

aaatgacaat gagctgaata tatggtttta caaagtagac atccacttgc aaaatgtttg     2713

gatgtaatgt taaagcgcaa tgtgcaaaat ttaaaataaa gaatatttat taatacgcac     2773

agtaaaaaaa aaaaaaaaaa aaaaaaaaa                                       2802


<210>  174
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Ala Arg Leu Val Ala Val Cys Arg Asp Gly Glu Glu Glu Phe Pro 
1               5                   10                  15      


Phe Glu Arg Arg Gln Ile Pro Leu Tyr Ile Asp Asp Thr Leu Thr Met 
            20                  25                  30          


Val Met Glu Phe Pro Asp Asn Val Leu Asn Leu Asp Gly His Gln Asn 
        35                  40                  45              


Asn Gly Ala Gln Leu Lys Gln Phe Ile Gln Arg His Gly Met Leu Lys 
    50                  55                  60                  


Gln Gln Asp Leu Ser Ile Ala Met Val Val Thr Ser Arg Glu Val Leu 
65                  70                  75                  80  


Ser Ala Leu Ser Gln Leu Val Pro Cys Val Gly Cys Arg Arg Ser Val 
                85                  90                  95      


Glu Arg Leu Phe Ser Gln Leu Val Glu Ser Gly Asn Pro Ala Leu Glu 
            100                 105                 110         


Pro Leu Thr Val Gly Pro Lys Gly Val Leu Ser Val Thr Arg Ser Cys 
        115                 120                 125             


Met Thr Asp Ala Lys Lys Leu Tyr Thr Leu Phe Tyr Val His Gly Ser 
    130                 135                 140                 


Lys Leu Asn Asp Met Ile Asp Ala Ile Pro Lys Ser Lys Lys Asn Lys 
145                 150                 155                 160 


Arg Cys Gln Leu His Ser Leu Asp Thr His Lys Pro Lys Pro Leu Gly 
                165                 170                 175     


Gly Cys Trp Met Asp Val Trp Glu Leu Met Ser Gln Glu Cys Arg Asp 
            180                 185                 190         


Glu Val Val Leu Ile Asp Ser Ser Cys Leu Leu Glu Thr Leu Glu Thr 
        195                 200                 205             


Tyr Leu Arg Lys His Arg Phe Cys Thr Asp Cys Lys Asn Lys Val Leu 
    210                 215                 220                 


Arg Ala Tyr Asn Ile Leu Ile Gly Glu Leu Asp Cys Ser Lys Glu Lys 
225                 230                 235                 240 


Gly Tyr Cys Ala Ala Leu Tyr Glu Gly Leu Arg Cys Cys Pro His Glu 
                245                 250                 255     


Arg His Ile His Val Cys Cys Glu Thr Asp Phe Ile Ala His Leu Leu 
            260                 265                 270         


Gly Arg Ala Glu Pro Glu Phe Ala Gly Gly Arg Arg Glu Arg His Ala 
        275                 280                 285             


Lys Thr Ile Asp Ile Ala Gln Glu Glu Val Leu Thr Cys Leu Gly Ile 
    290                 295                 300                 


His Leu Tyr Glu Arg Leu His Arg Ile Trp Gln Lys Leu Arg Ala Glu 
305                 310                 315                 320 


Glu Gln Thr Trp Gln Met Leu Phe Tyr Leu Gly Val Asp Ala Leu Arg 
                325                 330                 335     


Lys Ser Phe Glu Met Thr Val Glu Lys Val Gln Gly Ile Ser Arg Leu 
            340                 345                 350         


Glu Gln Leu Cys Glu Glu Phe Ser Glu Glu Glu Arg Val Arg Glu Leu 
        355                 360                 365             


Lys Gln Glu Lys Lys Arg Gln Lys Arg Lys Asn Arg Arg Lys Asn Lys 
    370                 375                 380                 


Cys Val Cys Asp Ile Pro Thr Pro Leu Gln Thr Ala Asp Glu Lys Glu 
385                 390                 395                 400 


Val Ser Gln Glu Lys Glu Thr Asp Phe Ile Glu Asn Ser Ser Cys Lys 
                405                 410                 415     


Ala Cys Gly Ser Thr Glu Asp Gly Asn Thr Cys Val Glu Val Ile Val 
            420                 425                 430         


Thr Asn Glu Asn Thr Ser Cys Thr Cys Pro Ser Ser Gly Asn Leu Leu 
        435                 440                 445             


Gly Ser Pro Lys Ile Lys Lys Gly Leu Ser Pro His Cys Asn Gly Ser 
    450                 455                 460                 


Asp Cys Gly Tyr Ser Ser Ser Met Glu Gly Ser Glu Thr Gly Ser Arg 
465                 470                 475                 480 


Glu Gly Ser Asp Val Ala Cys Thr Glu Gly Ile Cys Asn His Asp Glu 
                485                 490                 495     


His Gly Asp Asp Ser Cys Val His His Cys Glu Asp Lys Glu Asp Asp 
            500                 505                 510         


Gly Asp Ser Cys Val Glu Cys Trp Ala Asn Ser Glu Glu Asn Asp Thr 
        515                 520                 525             


Lys Gly Lys Asn Lys Lys Lys Lys Lys Lys Ser Lys Ile Leu Lys Cys 
    530                 535                 540                 


Asp Glu His Ile Gln Lys Leu Gly Ser Cys Ile Thr Asp Pro Gly Asn 
545                 550                 555                 560 


Arg Glu Thr Ser Gly Asn Thr Met His Thr Val Phe His Arg Asp Lys 
                565                 570                 575     


Thr Lys Asp Thr His Pro Glu Ser Cys Cys Ser Ser Glu Lys Gly Gly 
            580                 585                 590         


Gln Pro Leu Pro Trp Phe Glu His Arg Lys Asn Val Pro Gln Phe Ala 
        595                 600                 605             


Glu Pro Thr Glu Thr Leu Phe Gly Pro Asp Ser Gly Lys Gly Ala Lys 
    610                 615                 620                 


Ser Leu Val Glu Leu Leu Asp Glu Ser Glu Cys Thr Ser Asp Glu Glu 
625                 630                 635                 640 


Ile Phe Ile Ser Gln Asp Glu Ile Gln Ser Phe Met Ala Asn Asn Gln 
                645                 650                 655     


Ser Phe Tyr Ser Asn Arg Glu Gln Tyr Arg Gln His Leu Lys Glu Lys 
            660                 665                 670         


Phe Asn Lys Tyr Cys Arg Leu Asn Asp His Lys Arg Pro Ile Cys Ser 
        675                 680                 685             


Gly Trp Leu Thr Thr Ala Gly Ala Asn 
    690                 695         


<210>  175
<211>  1647
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (215)..(1279)

<400>  175
agcggtggag cttggcataa agttcaaatg ctcctacacc ctgccctgca gtatctctaa       60

ccaggggact ttgataagga agctgaaggg tgatattacc tttgctccct cactgcaact      120

gaacacattt cttagttttt aggtggcccc cgctggctaa cttgctgtgg agttttcaag      180

ggcatagaat cgtcctttac acaattaaaa gaag atg ctg ttt aat ctg agg atc      235
                                      Met Leu Phe Asn Leu Arg Ile         
                                      1               5                   

ctg tta aac aat gca gct ttt aga aat ggt cac aac ttc atg gtt cga        283
Leu Leu Asn Asn Ala Ala Phe Arg Asn Gly His Asn Phe Met Val Arg           
        10                  15                  20                        

aat ttt cgg tgt gga caa cca cta caa aat aaa gtg cag ctg aag ggc        331
Asn Phe Arg Cys Gly Gln Pro Leu Gln Asn Lys Val Gln Leu Lys Gly           
    25                  30                  35                            

cgt gac ctt ctc act cta aaa aac ttt acc gga gaa gaa att aaa tat        379
Arg Asp Leu Leu Thr Leu Lys Asn Phe Thr Gly Glu Glu Ile Lys Tyr           
40                  45                  50                  55            

atg cta tgg cta tca gca gat ctg aaa ttt agg ata aaa cag aaa gga        427
Met Leu Trp Leu Ser Ala Asp Leu Lys Phe Arg Ile Lys Gln Lys Gly           
                60                  65                  70                

gag tat ttg cct tta ttg caa ggg aag tcc tta ggc atg att ttt gag        475
Glu Tyr Leu Pro Leu Leu Gln Gly Lys Ser Leu Gly Met Ile Phe Glu           
            75                  80                  85                    

aaa aga agt act cga aca aga ttg tct aca gaa aca ggc ttt gca ctt        523
Lys Arg Ser Thr Arg Thr Arg Leu Ser Thr Glu Thr Gly Phe Ala Leu           
        90                  95                  100                       

ctg gga gga cat cct tgt ttt ctt acc aca caa gat att cat ttg ggt        571
Leu Gly Gly His Pro Cys Phe Leu Thr Thr Gln Asp Ile His Leu Gly           
    105                 110                 115                           

gtg aat gaa agt ctc acg gac acg gcc cgt gta ttg tct agc atg gca        619
Val Asn Glu Ser Leu Thr Asp Thr Ala Arg Val Leu Ser Ser Met Ala           
120                 125                 130                 135           

gat gca gta ttg gct cga gtg tat aaa caa tca gat ttg gac acc ctg        667
Asp Ala Val Leu Ala Arg Val Tyr Lys Gln Ser Asp Leu Asp Thr Leu           
                140                 145                 150               

gct aaa gaa gca tcc atc cca att atc aat ggg ctg tca gat ttg tac        715
Ala Lys Glu Ala Ser Ile Pro Ile Ile Asn Gly Leu Ser Asp Leu Tyr           
            155                 160                 165                   

cat cct atc cag atc ctg gct gat tac ctc acg ctc cag gaa cac tat        763
His Pro Ile Gln Ile Leu Ala Asp Tyr Leu Thr Leu Gln Glu His Tyr           
        170                 175                 180                       

agc tct ctg aaa ggt ctt acc ctc agc tgg atc ggg gat ggg aac aat        811
Ser Ser Leu Lys Gly Leu Thr Leu Ser Trp Ile Gly Asp Gly Asn Asn           
    185                 190                 195                           

atc ctg cac tcc atc atg atg agc gca gcg aaa ttc gga atg cac ctt        859
Ile Leu His Ser Ile Met Met Ser Ala Ala Lys Phe Gly Met His Leu           
200                 205                 210                 215           

cag gca gct act cca aag ggt tat gag ccg gat gct agt gta acc aag        907
Gln Ala Ala Thr Pro Lys Gly Tyr Glu Pro Asp Ala Ser Val Thr Lys           
                220                 225                 230               

ttg gca gag cag tat gcc aaa gag aat ggt acc aag ctg ttg ctg aca        955
Leu Ala Glu Gln Tyr Ala Lys Glu Asn Gly Thr Lys Leu Leu Leu Thr           
            235                 240                 245                   

aat gat cca ttg gaa gca gcg cat gga ggc aat gta tta att aca gac       1003
Asn Asp Pro Leu Glu Ala Ala His Gly Gly Asn Val Leu Ile Thr Asp           
        250                 255                 260                       

act tgg ata agc atg gga caa gaa gag gag aag aaa aag cgg ctc cag       1051
Thr Trp Ile Ser Met Gly Gln Glu Glu Glu Lys Lys Lys Arg Leu Gln           
    265                 270                 275                           

gct ttc caa ggt tac cag gtt aca atg aag act gct aaa gtt gct gcc       1099
Ala Phe Gln Gly Tyr Gln Val Thr Met Lys Thr Ala Lys Val Ala Ala           
280                 285                 290                 295           

tct gac tgg aca ttt tta cac tgc ttg ccc aga aag cca gaa gaa gtg       1147
Ser Asp Trp Thr Phe Leu His Cys Leu Pro Arg Lys Pro Glu Glu Val           
                300                 305                 310               

gat gat gaa gtc ttt tat tct cct cga tca cta gtg ttc cca gag gca       1195
Asp Asp Glu Val Phe Tyr Ser Pro Arg Ser Leu Val Phe Pro Glu Ala           
            315                 320                 325                   

gaa aac aga aag tgg aca atc atg gct gtc atg gtg tcc ctg ctg aca       1243
Glu Asn Arg Lys Trp Thr Ile Met Ala Val Met Val Ser Leu Leu Thr           
        330                 335                 340                       

gat tac tca cct cag ctc cag aag cct aaa ttt tga tgttgtgtta            1289
Asp Tyr Ser Pro Gln Leu Gln Lys Pro Lys Phe                               
    345                 350                                               

cttgtcaaga aagaagcaat gttcttcagt aacagaatga gttggtttat ggggaaaaga     1349

gaagagaatc taaaaaataa acaaatccct aacacgtggt atgggtgaac cgtatgatat     1409

gctttgccat tgtgaaactt tccttaagcc tttaatttaa gtgctgatgc actgtaatac     1469

gtgcttaact ttgcttaaac tctctaattc ccaatttctg agttacattt agatatcata     1529

ttaattatca tatacattta cttcaacata aaatactgtg ttcataatgt ataatgtcta     1589

agccattaag tgtaatctat gcttattacc taaataaatt atcacccatg ctaattta       1647


<210>  176
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Leu Phe Asn Leu Arg Ile Leu Leu Asn Asn Ala Ala Phe Arg Asn 
1               5                   10                  15      


Gly His Asn Phe Met Val Arg Asn Phe Arg Cys Gly Gln Pro Leu Gln 
            20                  25                  30          


Asn Lys Val Gln Leu Lys Gly Arg Asp Leu Leu Thr Leu Lys Asn Phe 
        35                  40                  45              


Thr Gly Glu Glu Ile Lys Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys 
    50                  55                  60                  


Phe Arg Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys 
65                  70                  75                  80  


Ser Leu Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser 
                85                  90                  95      


Thr Glu Thr Gly Phe Ala Leu Leu Gly Gly His Pro Cys Phe Leu Thr 
            100                 105                 110         


Thr Gln Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr Asp Thr Ala 
        115                 120                 125             


Arg Val Leu Ser Ser Met Ala Asp Ala Val Leu Ala Arg Val Tyr Lys 
    130                 135                 140                 


Gln Ser Asp Leu Asp Thr Leu Ala Lys Glu Ala Ser Ile Pro Ile Ile 
145                 150                 155                 160 


Asn Gly Leu Ser Asp Leu Tyr His Pro Ile Gln Ile Leu Ala Asp Tyr 
                165                 170                 175     


Leu Thr Leu Gln Glu His Tyr Ser Ser Leu Lys Gly Leu Thr Leu Ser 
            180                 185                 190         


Trp Ile Gly Asp Gly Asn Asn Ile Leu His Ser Ile Met Met Ser Ala 
        195                 200                 205             


Ala Lys Phe Gly Met His Leu Gln Ala Ala Thr Pro Lys Gly Tyr Glu 
    210                 215                 220                 


Pro Asp Ala Ser Val Thr Lys Leu Ala Glu Gln Tyr Ala Lys Glu Asn 
225                 230                 235                 240 


Gly Thr Lys Leu Leu Leu Thr Asn Asp Pro Leu Glu Ala Ala His Gly 
                245                 250                 255     


Gly Asn Val Leu Ile Thr Asp Thr Trp Ile Ser Met Gly Gln Glu Glu 
            260                 265                 270         


Glu Lys Lys Lys Arg Leu Gln Ala Phe Gln Gly Tyr Gln Val Thr Met 
        275                 280                 285             


Lys Thr Ala Lys Val Ala Ala Ser Asp Trp Thr Phe Leu His Cys Leu 
    290                 295                 300                 


Pro Arg Lys Pro Glu Glu Val Asp Asp Glu Val Phe Tyr Ser Pro Arg 
305                 310                 315                 320 


Ser Leu Val Phe Pro Glu Ala Glu Asn Arg Lys Trp Thr Ile Met Ala 
                325                 330                 335     


Val Met Val Ser Leu Leu Thr Asp Tyr Ser Pro Gln Leu Gln Lys Pro 
            340                 345                 350         


Lys Phe 
        


<210>  177
<211>  861
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(861)

<400>  177
atg tta ttt cgc tgc aac tat tta gct tta gct ggt ggt gga aaa aag         48
Met Leu Phe Arg Cys Asn Tyr Leu Ala Leu Ala Gly Gly Gly Lys Lys           
1               5                   10                  15                

ccg aaa tac cct ccc aac aaa gta atg atc tgg gat gac ctg aag aag         96
Pro Lys Tyr Pro Pro Asn Lys Val Met Ile Trp Asp Asp Leu Lys Lys           
            20                  25                  30                    

aag act gtt att gaa ata gaa ttt tct aca gaa gtc aag gca gtc aaa        144
Lys Thr Val Ile Glu Ile Glu Phe Ser Thr Glu Val Lys Ala Val Lys           
        35                  40                  45                        

ctg cgg cga gat aga att gtg gtg gtt ttg gac tcc atg att aag gtg        192
Leu Arg Arg Asp Arg Ile Val Val Val Leu Asp Ser Met Ile Lys Val           
    50                  55                  60                            

ttc aca ttc aca cac aat ccc cat cag ttg cac gtc ttc gaa acc tgc        240
Phe Thr Phe Thr His Asn Pro His Gln Leu His Val Phe Glu Thr Cys           
65                  70                  75                  80            

tat aac ccc aaa ggc ctc tgt gtc ctt tgt ccc aat agt aac aac tcc        288
Tyr Asn Pro Lys Gly Leu Cys Val Leu Cys Pro Asn Ser Asn Asn Ser           
                85                  90                  95                

ctc ctg gcc ttt ccg ggc acg cac acg ggc cat gtg cag ctt gtg gac        336
Leu Leu Ala Phe Pro Gly Thr His Thr Gly His Val Gln Leu Val Asp           
            100                 105                 110                   

ctg gcc agc acg gag aag cca ccc gtg gac att cct gca cac gag ggt        384
Leu Ala Ser Thr Glu Lys Pro Pro Val Asp Ile Pro Ala His Glu Gly           
        115                 120                 125                       

gtc ctg agc tgc att gca ctc aac ctg cag gga aca aga att gca act        432
Val Leu Ser Cys Ile Ala Leu Asn Leu Gln Gly Thr Arg Ile Ala Thr           
    130                 135                 140                           

gca tcc gag aaa ggg acg ctt ata aga ata ttt gat act tca tca ggg        480
Ala Ser Glu Lys Gly Thr Leu Ile Arg Ile Phe Asp Thr Ser Ser Gly           
145                 150                 155                 160           

cat tta atc cag gaa ctg cga aga gga tct caa gca gcc aat att tac        528
His Leu Ile Gln Glu Leu Arg Arg Gly Ser Gln Ala Ala Asn Ile Tyr           
                165                 170                 175               

tgc atc aac ttc aat cag gat gcg tcc ctc atc tgc gta tcc agc gac        576
Cys Ile Asn Phe Asn Gln Asp Ala Ser Leu Ile Cys Val Ser Ser Asp           
            180                 185                 190                   

cac ggc aca gtg cat att ttt gca gct gaa gat cca aaa agg aat aaa        624
His Gly Thr Val His Ile Phe Ala Ala Glu Asp Pro Lys Arg Asn Lys           
        195                 200                 205                       

cag tcc agt ttg gcc tca gcc agt ttc ctt cca aaa tac ttc agt tcc        672
Gln Ser Ser Leu Ala Ser Ala Ser Phe Leu Pro Lys Tyr Phe Ser Ser           
    210                 215                 220                           

aag tgg agt ttc tcc aag ttt cag gtt ccc tca ggc tct ccg tgc att        720
Lys Trp Ser Phe Ser Lys Phe Gln Val Pro Ser Gly Ser Pro Cys Ile           
225                 230                 235                 240           

tgt gcc ttt gga aca gag cca aac gcc gtc att gca att tgt gca gac        768
Cys Ala Phe Gly Thr Glu Pro Asn Ala Val Ile Ala Ile Cys Ala Asp           
                245                 250                 255               

ggc agc tac tac aaa ttc ctg ttc aac ccc aag ggg gag tgc atc cga        816
Gly Ser Tyr Tyr Lys Phe Leu Phe Asn Pro Lys Gly Glu Cys Ile Arg           
            260                 265                 270                   

gat gtc tac gcg cag ttt cta gag atg acc gat gac aag ctt taa            861
Asp Val Tyr Ala Gln Phe Leu Glu Met Thr Asp Asp Lys Leu                   
        275                 280                 285                       


<210>  178
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Leu Phe Arg Cys Asn Tyr Leu Ala Leu Ala Gly Gly Gly Lys Lys 
1               5                   10                  15      


Pro Lys Tyr Pro Pro Asn Lys Val Met Ile Trp Asp Asp Leu Lys Lys 
            20                  25                  30          


Lys Thr Val Ile Glu Ile Glu Phe Ser Thr Glu Val Lys Ala Val Lys 
        35                  40                  45              


Leu Arg Arg Asp Arg Ile Val Val Val Leu Asp Ser Met Ile Lys Val 
    50                  55                  60                  


Phe Thr Phe Thr His Asn Pro His Gln Leu His Val Phe Glu Thr Cys 
65                  70                  75                  80  


Tyr Asn Pro Lys Gly Leu Cys Val Leu Cys Pro Asn Ser Asn Asn Ser 
                85                  90                  95      


Leu Leu Ala Phe Pro Gly Thr His Thr Gly His Val Gln Leu Val Asp 
            100                 105                 110         


Leu Ala Ser Thr Glu Lys Pro Pro Val Asp Ile Pro Ala His Glu Gly 
        115                 120                 125             


Val Leu Ser Cys Ile Ala Leu Asn Leu Gln Gly Thr Arg Ile Ala Thr 
    130                 135                 140                 


Ala Ser Glu Lys Gly Thr Leu Ile Arg Ile Phe Asp Thr Ser Ser Gly 
145                 150                 155                 160 


His Leu Ile Gln Glu Leu Arg Arg Gly Ser Gln Ala Ala Asn Ile Tyr 
                165                 170                 175     


Cys Ile Asn Phe Asn Gln Asp Ala Ser Leu Ile Cys Val Ser Ser Asp 
            180                 185                 190         


His Gly Thr Val His Ile Phe Ala Ala Glu Asp Pro Lys Arg Asn Lys 
        195                 200                 205             


Gln Ser Ser Leu Ala Ser Ala Ser Phe Leu Pro Lys Tyr Phe Ser Ser 
    210                 215                 220                 


Lys Trp Ser Phe Ser Lys Phe Gln Val Pro Ser Gly Ser Pro Cys Ile 
225                 230                 235                 240 


Cys Ala Phe Gly Thr Glu Pro Asn Ala Val Ile Ala Ile Cys Ala Asp 
                245                 250                 255     


Gly Ser Tyr Tyr Lys Phe Leu Phe Asn Pro Lys Gly Glu Cys Ile Arg 
            260                 265                 270         


Asp Val Tyr Ala Gln Phe Leu Glu Met Thr Asp Asp Lys Leu 
        275                 280                 285     


<210>  179
<211>  3581
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (181)..(1359)

<400>  179
cgagaagtgc ttccaagcgt ccattttgag ccttggaaac tacgacgacc aaagggccac       60

gggttcatgg gtcgtttctc atttccgtcg agttaaacgt ctggggctgc ttctgaggaa      120

tcagcttgac tggccagcaa gttcagctcc ggcaagtcat ttgattcacc cggtgatgaa      180

atg ggg gtc aac cag tct gtg ggc ttt cca cct gtc aca gga ccc cac        228
Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val Thr Gly Pro His           
1               5                   10                  15                

ctc gta ggc tgt ggg gat gtg atg gag ggt cag aat ctc cag ggg agc        276
Leu Val Gly Cys Gly Asp Val Met Glu Gly Gln Asn Leu Gln Gly Ser           
            20                  25                  30                    

ttc ttt cga ctc ttc tac ccc tgc caa aag gca gag gag acc atg gag        324
Phe Phe Arg Leu Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu           
        35                  40                  45                        

cag ccc ctg tgg att ccc cgc tat gag tac tgc act ggc ctg gcc gag        372
Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr Gly Leu Ala Glu           
    50                  55                  60                            

tac ctg cag ttt aat aag cgc tgc ggg ggc ttg ctg ttc aac ctg gcg        420
Tyr Leu Gln Phe Asn Lys Arg Cys Gly Gly Leu Leu Phe Asn Leu Ala           
65                  70                  75                  80            

gtg gga tct tgt cgc ctg cct gtt agc tgg aat ggc ccc ttt aag aca        468
Val Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr           
                85                  90                  95                

aag gac tct gga tac ccc ttg atc atc ttc tcc cat ggc cta gga gcc        516
Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala           
            100                 105                 110                   

ttc agg act ttg tat tca gcc ttc tgc atg gag ctg gcc tca cgt ggc        564
Phe Arg Thr Leu Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly           
        115                 120                 125                       

ttt gtg gtt gct gtg cca gag cac agg gac cgg tca gcg gca acc acc        612
Phe Val Val Ala Val Pro Glu His Arg Asp Arg Ser Ala Ala Thr Thr           
    130                 135                 140                           

tat ttc tgc aag cag gcc cca gaa gag aac cag ccc acc aat gaa tcg        660
Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln Pro Thr Asn Glu Ser           
145                 150                 155                 160           

ctg cag gag gaa tgg atc cct ttc cgt cga gtt gag gaa ggg gag aag        708
Leu Gln Glu Glu Trp Ile Pro Phe Arg Arg Val Glu Glu Gly Glu Lys           
                165                 170                 175               

gaa ttt cat gtt cgg aat ccc cag gtg cat cag cgg gta agc gag tgt        756
Glu Phe His Val Arg Asn Pro Gln Val His Gln Arg Val Ser Glu Cys           
            180                 185                 190                   

tta cgg gtg ttg aag atc ctg caa gag gtc act gct ggg cag act gtc        804
Leu Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala Gly Gln Thr Val           
        195                 200                 205                       

ttc aac atc ttg cct ggt ggc ttg gat ctg atg act ttg aag ggc aac        852
Phe Asn Ile Leu Pro Gly Gly Leu Asp Leu Met Thr Leu Lys Gly Asn           
    210                 215                 220                           

att gac atg agc cgt gtg gct gtg atg gga cat tca ttt gga ggg gcc        900
Ile Asp Met Ser Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala           
225                 230                 235                 240           

aca gct att ctg gct ttg gcc aag gag acc caa ttt cgg tgt gcg gtg        948
Thr Ala Ile Leu Ala Leu Ala Lys Glu Thr Gln Phe Arg Cys Ala Val           
                245                 250                 255               

gct ctg gat gct tgg atg ttt cct ctg gaa cgt gac ttt tac ccc aag        996
Ala Leu Asp Ala Trp Met Phe Pro Leu Glu Arg Asp Phe Tyr Pro Lys           
            260                 265                 270                   

gcc cga gga cct gtg ttc ttt atc aat act gag aaa ttc cag aca atg       1044
Ala Arg Gly Pro Val Phe Phe Ile Asn Thr Glu Lys Phe Gln Thr Met           
        275                 280                 285                       

gag agt gtc aat ttg atg aag aag ata tgt gcc cag cat gaa cag tct       1092
Glu Ser Val Asn Leu Met Lys Lys Ile Cys Ala Gln His Glu Gln Ser           
    290                 295                 300                           

agg atc ata acc gtt ctt ggt tct gtt cat cgg agt caa act gac ttt       1140
Arg Ile Ile Thr Val Leu Gly Ser Val His Arg Ser Gln Thr Asp Phe           
305                 310                 315                 320           

gct ttt gtg act ggc aac ttg att ggt aaa ttc ttc tcc act gaa acc       1188
Ala Phe Val Thr Gly Asn Leu Ile Gly Lys Phe Phe Ser Thr Glu Thr           
                325                 330                 335               

cgt ggg agc ctg gac ccc tat gaa ggg cag gag gtt atg gta cgg gcc       1236
Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Val Met Val Arg Ala           
            340                 345                 350                   

atg ttg gcc ttc ctg cag aag cac ctc gac ctg aaa gaa gac tat aat       1284
Met Leu Ala Phe Leu Gln Lys His Leu Asp Leu Lys Glu Asp Tyr Asn           
        355                 360                 365                       

caa tgg aac aac ctt att gaa ggc att gga ccg tcg ctc acc cca ggg       1332
Gln Trp Asn Asn Leu Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly           
    370                 375                 380                           

gcc ccc cac cat ctg tcc agc ctg tag gcacaactgg ccatttgtaa             1379
Ala Pro His His Leu Ser Ser Leu                                           
385                 390                                                   

agtcacttca gccaagtttt catttgggag ctacccaagg gcacccatga gctcctatca     1439

agaagtgatc aacgtgaccc cttttcacag attgaaaggt gtaatcacac tgctgcttgg     1499

ataactgggt actttgatct tagatttgat cttaaaatca ctttgggact gggatccctt     1559

gctgattgac aaacagactt tctgggacct tgatggagtg gggaacaagc agtagagtgg     1619

gactggggga gacccaggcc ccgggctgag cactgtgagg cctggatgtg aagactcagc     1679

ccagcgaagc tcattccctt acccccggcc agtgctgctg cttcagtgga agagatgaag     1739

ccaaaggaca gaatgaaaat ccctaccttc agagactcta gcccagccca acaccatctc     1799

ttcctacctc tcagccttct ccctccccag ggccacttgt tgaagtctga gcactttatg     1859

taaatttcta ggtgtgagcc gtgatcacat tttctattta tttccaagtc ttctcattgt     1919

atggaacata gtactactta tacttacagt agtaagttat acttgtgagc ccacagagtg     1979

gcagacagca tggctctcac agcacaggga gaaaaactga ggtacacaga ggtacctcag     2039

aagctctgga tgtctttggg ggttttgcta agtgtatctt gataggaaac aacaaaagca     2099

ggttgagatg gggaagatga cagaacaaca gtgttaaatg gccatttgca caggcctttg     2159

ccacaacaga gaagtagttt ggtcagctaa aactcagctg cagcctggac agtagagcga     2219

gaccccatct taaaaataaa gaaggctggg cgtggtggct catgcctgta atcccaacac     2279

tttgggaggc caaggcaggc agatcactta aggccaggag ttcaagacca cctggccaac     2339

atggtgaaac cccgtctcta ctaaaaatac aaaaaattag cctggcgtaa tggcaggcgc     2399

ctataatccc agctactcag gaggctgaag cagaagaatc acttgaacct aggaggcgga     2459

ggttgcagtg agtcaagatc gcgccactgc actccagcct gggtgacaga gcaagactct     2519

gtcttaaaaa aaaaaaaaag aaaaagaaaa atttaaaata aataaaattt aaaaacgcag     2579

aaggccactc ccagagaggc ctaggagtac cttggtcatt ttttcttgcc tcaaatatta     2639

taaacctcca acttgctcag aatcagggtg cttttattgt ctgttttctg gctctgaggc     2699

ccttgcccca aatttaagtc agatacagac tgaatttcca ttctgttctg tttataatat     2759

gaatgatatt aatactcttg tttgcttaat gttatgttgg aattttctgt ttaatctgca     2819

gtagagcaag atggagagcc atctggaatt gacttccttc tgtctttctt ctgtgttcgc     2879

ttactacttg ggcccatgtg ggaaaaaaac tttaaaagga aggaagtctt cttagggatc     2939

cagttcaaag ctatttgggg gcatcaaact gaaactctct tctccactac tcaagacttc     2999

gtgcctcagt ccaagtaggt aagagcaaaa gggaaatgca tctctacaca atggcccatg     3059

gtcagggcca ccagagcaag ctgggcctag atctccacct gtcagtgact ggccattcta     3119

agaggtgaaa cagcagatcg ttgaggctgt gagggaggat ctttgaattc ccatgagaca     3179

tagcataaga agggtatcat taaagccctg ggctctaaag ttacagagcc tggttttgag     3239

tcctggctcc accactgcca actgggtaaa tttgagcaaa tggtattctc tttcttatct     3299

cagctcctgc gtttctaaaa tgagggtctg cgttatgaat agttaggagg attaagtgag     3359

aggatgtata acccatgggt tacttaaaag tatatttcct accttccaaa catgagattt     3419

ttctagttat agtttctttt ctagcttgat tgctttgtgg tcagagaaaa tgacccatat     3479

ggtttccatc cttcaaaatt tgttgaaact tggttgttgg cctagtatga gatcaatgtt     3539

gtaaatgtgc catgtatgtt taaaaagact atatattctg aa                        3581


<210>  180
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val Thr Gly Pro His 
1               5                   10                  15      


Leu Val Gly Cys Gly Asp Val Met Glu Gly Gln Asn Leu Gln Gly Ser 
            20                  25                  30          


Phe Phe Arg Leu Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu 
        35                  40                  45              


Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr Gly Leu Ala Glu 
    50                  55                  60                  


Tyr Leu Gln Phe Asn Lys Arg Cys Gly Gly Leu Leu Phe Asn Leu Ala 
65                  70                  75                  80  


Val Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr 
                85                  90                  95      


Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala 
            100                 105                 110         


Phe Arg Thr Leu Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly 
        115                 120                 125             


Phe Val Val Ala Val Pro Glu His Arg Asp Arg Ser Ala Ala Thr Thr 
    130                 135                 140                 


Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln Pro Thr Asn Glu Ser 
145                 150                 155                 160 


Leu Gln Glu Glu Trp Ile Pro Phe Arg Arg Val Glu Glu Gly Glu Lys 
                165                 170                 175     


Glu Phe His Val Arg Asn Pro Gln Val His Gln Arg Val Ser Glu Cys 
            180                 185                 190         


Leu Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala Gly Gln Thr Val 
        195                 200                 205             


Phe Asn Ile Leu Pro Gly Gly Leu Asp Leu Met Thr Leu Lys Gly Asn 
    210                 215                 220                 


Ile Asp Met Ser Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala 
225                 230                 235                 240 


Thr Ala Ile Leu Ala Leu Ala Lys Glu Thr Gln Phe Arg Cys Ala Val 
                245                 250                 255     


Ala Leu Asp Ala Trp Met Phe Pro Leu Glu Arg Asp Phe Tyr Pro Lys 
            260                 265                 270         


Ala Arg Gly Pro Val Phe Phe Ile Asn Thr Glu Lys Phe Gln Thr Met 
        275                 280                 285             


Glu Ser Val Asn Leu Met Lys Lys Ile Cys Ala Gln His Glu Gln Ser 
    290                 295                 300                 


Arg Ile Ile Thr Val Leu Gly Ser Val His Arg Ser Gln Thr Asp Phe 
305                 310                 315                 320 


Ala Phe Val Thr Gly Asn Leu Ile Gly Lys Phe Phe Ser Thr Glu Thr 
                325                 330                 335     


Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Val Met Val Arg Ala 
            340                 345                 350         


Met Leu Ala Phe Leu Gln Lys His Leu Asp Leu Lys Glu Asp Tyr Asn 
        355                 360                 365             


Gln Trp Asn Asn Leu Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly 
    370                 375                 380                 


Ala Pro His His Leu Ser Ser Leu 
385                 390         


<210>  181
<211>  6488
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2535)

<400>  181
atg tcc aag agg ggc atg agc agc cgg gcc aag ggg gac aag gca gag         48
Met Ser Lys Arg Gly Met Ser Ser Arg Ala Lys Gly Asp Lys Ala Glu           
1               5                   10                  15                

gcc ctc gcg gcg ctg cag gcg gcc aac gag gat ctt cga gcc aag ctc         96
Ala Leu Ala Ala Leu Gln Ala Ala Asn Glu Asp Leu Arg Ala Lys Leu           
            20                  25                  30                    

aca gac atc cag atc gag ctg cag cag gag aag agc aag gtc agc aaa        144
Thr Asp Ile Gln Ile Glu Leu Gln Gln Glu Lys Ser Lys Val Ser Lys           
        35                  40                  45                        

gtg gaa cgc gag aag aac cag gag ctg cgg cag gtg cgc gag cat gag        192
Val Glu Arg Glu Lys Asn Gln Glu Leu Arg Gln Val Arg Glu His Glu           
    50                  55                  60                            

cag cat aag acc gcg gtc ttg ctc acg gag ctc aag aca aag ctg cac        240
Gln His Lys Thr Ala Val Leu Leu Thr Glu Leu Lys Thr Lys Leu His           
65                  70                  75                  80            

gag gag aag atg aag gag cta cag gct gtg cgt gag acg ctg ctg cgg        288
Glu Glu Lys Met Lys Glu Leu Gln Ala Val Arg Glu Thr Leu Leu Arg           
                85                  90                  95                

cag cat gag gct gag ctg ctc agg gtc atc aag atc aag gac aac gag        336
Gln His Glu Ala Glu Leu Leu Arg Val Ile Lys Ile Lys Asp Asn Glu           
            100                 105                 110                   

aac cag cgg ctg cag gca ctg ctc agt gcc ctg cgt gat ggc ggc ccc        384
Asn Gln Arg Leu Gln Ala Leu Leu Ser Ala Leu Arg Asp Gly Gly Pro           
        115                 120                 125                       

gaa aag gtc aag acc gtg ctg ctg tcc gag gcc aag gag gag gcc aag        432
Glu Lys Val Lys Thr Val Leu Leu Ser Glu Ala Lys Glu Glu Ala Lys           
    130                 135                 140                           

aag ggg ttc gag gtg gag aag gtc aag atg cag cag gag atc tcc gag        480
Lys Gly Phe Glu Val Glu Lys Val Lys Met Gln Gln Glu Ile Ser Glu           
145                 150                 155                 160           

ctc aag ggc gcc aaa agg cag gtg gag gag gcg ctg acg ctg gtg atc        528
Leu Lys Gly Ala Lys Arg Gln Val Glu Glu Ala Leu Thr Leu Val Ile           
                165                 170                 175               

caa gcg gac aag atc aag gcc gca gag atc cgc agc gtg tac cac ctg        576
Gln Ala Asp Lys Ile Lys Ala Ala Glu Ile Arg Ser Val Tyr His Leu           
            180                 185                 190                   

cac cag gag gag atc acc cgc atc aag aag gag tgc gag cgg gag atc        624
His Gln Glu Glu Ile Thr Arg Ile Lys Lys Glu Cys Glu Arg Glu Ile           
        195                 200                 205                       

cgc agg ctg atg gag gag ata aaa ttt aaa gac aga gca gtc ttc gtg        672
Arg Arg Leu Met Glu Glu Ile Lys Phe Lys Asp Arg Ala Val Phe Val           
    210                 215                 220                           

ctg gag aga gag tta ggg gtt caa gcc ggg cat gct cag aga ctg cag        720
Leu Glu Arg Glu Leu Gly Val Gln Ala Gly His Ala Gln Arg Leu Gln           
225                 230                 235                 240           

ctc caa aaa gag gct cta gat gag cag ctg tcc cag gtc cga gag gcc        768
Leu Gln Lys Glu Ala Leu Asp Glu Gln Leu Ser Gln Val Arg Glu Ala           
                245                 250                 255               

gac cgg cac ccg ggc agc ccc aga cgg gaa ctt cct cat gca gct ggt        816
Asp Arg His Pro Gly Ser Pro Arg Arg Glu Leu Pro His Ala Ala Gly           
            260                 265                 270                   

gca gga gac gct tca gac cac tcg gga agc cct gaa cag cag ttg gat        864
Ala Gly Asp Ala Ser Asp His Ser Gly Ser Pro Glu Gln Gln Leu Asp           
        275                 280                 285                       

gaa aaa gat gcc cgg cgc ttc cag ctt aaa atc gcg gag tta agt gcg        912
Glu Lys Asp Ala Arg Arg Phe Gln Leu Lys Ile Ala Glu Leu Ser Ala           
    290                 295                 300                           

att atc cgc aaa ctg gag gac cgc aat gca ttg ctg tcg gaa gag agg        960
Ile Ile Arg Lys Leu Glu Asp Arg Asn Ala Leu Leu Ser Glu Glu Arg           
305                 310                 315                 320           

aat gag ctg ttg aag cgc gta aga gaa gct gag agt cag tac aag cct       1008
Asn Glu Leu Leu Lys Arg Val Arg Glu Ala Glu Ser Gln Tyr Lys Pro           
                325                 330                 335               

ctg ctg gat aaa aac aag cgc ctc agt cgg aag aac gag gat ttg tct       1056
Leu Leu Asp Lys Asn Lys Arg Leu Ser Arg Lys Asn Glu Asp Leu Ser           
            340                 345                 350                   

cat gct tta cgc cga atg gaa aac aag tta aaa ttt gtc acc cag gag       1104
His Ala Leu Arg Arg Met Glu Asn Lys Leu Lys Phe Val Thr Gln Glu           
        355                 360                 365                       

aac ata gaa atg aga cag aga gct gga atc ata cgg aga ccc agt tcc       1152
Asn Ile Glu Met Arg Gln Arg Ala Gly Ile Ile Arg Arg Pro Ser Ser           
    370                 375                 380                           

ttg aat gac ctt gat caa agt cag gat gag aga gaa gtc gat ttc ttg       1200
Leu Asn Asp Leu Asp Gln Ser Gln Asp Glu Arg Glu Val Asp Phe Leu           
385                 390                 395                 400           

aag ctt cag att gtg gag cag caa aac ctc ata gat gaa ctg tct aag       1248
Lys Leu Gln Ile Val Glu Gln Gln Asn Leu Ile Asp Glu Leu Ser Lys           
                405                 410                 415               

acc ctt gag acc gcc ggc tac gtg aag agc gtg tta gag cgg gac aag       1296
Thr Leu Glu Thr Ala Gly Tyr Val Lys Ser Val Leu Glu Arg Asp Lys           
            420                 425                 430                   

ctg tta aga ttc cgg aag caa aga aag aaa atg gca aaa ctt ccc aag       1344
Leu Leu Arg Phe Arg Lys Gln Arg Lys Lys Met Ala Lys Leu Pro Lys           
        435                 440                 445                       

ccg gtg gtt gtg gag acc ttc ttt gga tac gac gaa gag gct tcc ctg       1392
Pro Val Val Val Glu Thr Phe Phe Gly Tyr Asp Glu Glu Ala Ser Leu           
    450                 455                 460                           

gaa tcc gac ggc tcc tcc gtc tct tac caa aca gac agg acg gac cag       1440
Glu Ser Asp Gly Ser Ser Val Ser Tyr Gln Thr Asp Arg Thr Asp Gln           
465                 470                 475                 480           

acc ccg tgc acc ccg gac gat gac ttg gag gag ggc atg gcc aag gag       1488
Thr Pro Cys Thr Pro Asp Asp Asp Leu Glu Glu Gly Met Ala Lys Glu           
                485                 490                 495               

gag acg gag ctg agg ttc cgg cag ctg acc atg gag tac cag gcc ctg       1536
Glu Thr Glu Leu Arg Phe Arg Gln Leu Thr Met Glu Tyr Gln Ala Leu           
            500                 505                 510                   

cag cgt gcc tac gct ttg ttg cag gag cag gtt gga ggg acg ctg gac       1584
Gln Arg Ala Tyr Ala Leu Leu Gln Glu Gln Val Gly Gly Thr Leu Asp           
        515                 520                 525                       

gca gag cga gaa gtt aag acc cgt gag cag cta caa gcc gaa gtg cag       1632
Ala Glu Arg Glu Val Lys Thr Arg Glu Gln Leu Gln Ala Glu Val Gln           
    530                 535                 540                           

agg gca cag gcg cgg ata gag gac ctg gag aag gcc ctg gcg gag cag       1680
Arg Ala Gln Ala Arg Ile Glu Asp Leu Glu Lys Ala Leu Ala Glu Gln           
545                 550                 555                 560           

ggg cag gat atg aag tgg att gaa gag aag cag gca ctg tac cgg aga       1728
Gly Gln Asp Met Lys Trp Ile Glu Glu Lys Gln Ala Leu Tyr Arg Arg           
                565                 570                 575               

aat caa gag ctt gtg gaa aag atc aaa caa atg gag acg gaa gag gct       1776
Asn Gln Glu Leu Val Glu Lys Ile Lys Gln Met Glu Thr Glu Glu Ala           
            580                 585                 590                   

cgg ctc aga cac gag gtg cag gac gcc aga gac caa aac gag ctg ctg       1824
Arg Leu Arg His Glu Val Gln Asp Ala Arg Asp Gln Asn Glu Leu Leu           
        595                 600                 605                       

gag ttc agg atc ctg gag ctt gag gag agg gag agg aag tca ccc gcc       1872
Glu Phe Arg Ile Leu Glu Leu Glu Glu Arg Glu Arg Lys Ser Pro Ala           
    610                 615                 620                           

atc agc ttc cac cac acg ccc ttc gtg gac ggg aag agc ccc ctc cag       1920
Ile Ser Phe His His Thr Pro Phe Val Asp Gly Lys Ser Pro Leu Gln           
625                 630                 635                 640           

gtg tac tgc gag gcc gaa ggt gtg acg gac att gtg gtt gcg gag ctg       1968
Val Tyr Cys Glu Ala Glu Gly Val Thr Asp Ile Val Val Ala Glu Leu           
                645                 650                 655               

atg aag aag ctg gac atc ctg ggc gat aac gcc aac ctg acc aat gag       2016
Met Lys Lys Leu Asp Ile Leu Gly Asp Asn Ala Asn Leu Thr Asn Glu           
            660                 665                 670                   

gag cag gtg gtt gtc ata caa gcc agg aca gtc ctg acc ttg gcc gaa       2064
Glu Gln Val Val Val Ile Gln Ala Arg Thr Val Leu Thr Leu Ala Glu           
        675                 680                 685                       

aag tgg ctc cag cag att gag gag aca gag gcg gcg ctg cag cgg aag       2112
Lys Trp Leu Gln Gln Ile Glu Glu Thr Glu Ala Ala Leu Gln Arg Lys           
    690                 695                 700                           

atg gtg gat ctg gag agc gag aag gag ctg ttc agt aag cag aag ggc       2160
Met Val Asp Leu Glu Ser Glu Lys Glu Leu Phe Ser Lys Gln Lys Gly           
705                 710                 715                 720           

tac ctg gac gag gag ctg gac tac cgg aaa cag gcc ttg gac cag gcc       2208
Tyr Leu Asp Glu Glu Leu Asp Tyr Arg Lys Gln Ala Leu Asp Gln Ala           
                725                 730                 735               

aac aag cac atc ctg gag ctg gaa gcc atg ctg tat gat gcc ctg cag       2256
Asn Lys His Ile Leu Glu Leu Glu Ala Met Leu Tyr Asp Ala Leu Gln           
            740                 745                 750                   

cag gag gcc ggg gct aag gtg gct gag ctg ctg tca gag gag gag cgc       2304
Gln Glu Ala Gly Ala Lys Val Ala Glu Leu Leu Ser Glu Glu Glu Arg           
        755                 760                 765                       

gag aag ctc aag gtg gcc gtg gag cag tgg aag cgc cag gtc atg agt       2352
Glu Lys Leu Lys Val Ala Val Glu Gln Trp Lys Arg Gln Val Met Ser           
    770                 775                 780                           

gag ctg cgc gag cgg gac gcc cag atc ctg cgg gag cgc atg gag ctg       2400
Glu Leu Arg Glu Arg Asp Ala Gln Ile Leu Arg Glu Arg Met Glu Leu           
785                 790                 795                 800           

ctg cag ctg gct cag cag aga att aaa gag tta gaa gaa aga ata gaa       2448
Leu Gln Leu Ala Gln Gln Arg Ile Lys Glu Leu Glu Glu Arg Ile Glu           
                805                 810                 815               

gct cag aag aga caa ata aag gaa ctg gag gaa aag ttt cta ttt ttg       2496
Ala Gln Lys Arg Gln Ile Lys Glu Leu Glu Glu Lys Phe Leu Phe Leu           
            820                 825                 830                   

ttc tta ttt ttc tcc tta gct ttc att ctc tgg tca tag tccgtcttgg        2545
Phe Leu Phe Phe Ser Leu Ala Phe Ile Leu Trp Ser                           
        835                 840                                           

caccctgacg tgccccacat tgaatcggac ccttttcctc cagtgggacc agaaagcagg     2605

gacaaaatgg gacgtcgcgt ctccatcctg aagacccagg gagatttggt ctctgcacgc     2665

ccgtcccgtg gaggaagagt gagaaggggc agtgtgtggg gcgtggagct gccgtccacg     2725

tgggatgtgc cagaactaga actggctctg ccgacttctc gggggcttct ccgggacggg     2785

cctggccttg gctgctggac cctgggtccc ttctcccgga cggcagcccc catcccattt     2845

ccagggatgt gtagcattcc ctgccaagca ggggtgagaa ctgcttctgt gcagaagcac     2905

cagccgcggg tcccctcctc tctcttggtt ctcacagtag ctgccactgg tgtctggagg     2965

aagattttca gaaacaacag aggcttggcc tgatgacaag atgaaagctg gacggtgacc     3025

ttcattcagg ggaacctgga ggctccctgg gatggtcctg ggagggctcc ccgacgcctc     3085

aggggcccct ccgatgctgc aatatgttgc tggggtcctg agcacccgct ggccaacaga     3145

ccccacatcc accctcgttc atcatcatct ctgtggggac agacaagagc cgtggccgcc     3205

gcgggccgcg tggtgccatc aaccctctgc ctccctactc aacctgagac aggaaggcca     3265

agatcccgcc caagccgcca gctgggagca ccgcgggact gagccaagga aggcgtgggg     3325

agcgtggtga caggaggtgg gacgaggggg cggagctggc tggaacacgg atgccagagg     3385

ctgcctccat agtgaatctc cagaagtcac agaggccctg ggcacccaga gccacccagc     3445

ctggaagccc ctgcacgggc cagccctgca ggccatggac cccggcgggc accgaagcct     3505

caccccaagc ctttgcacac aaggagcagc ccaggtgggg atggcgggcg caagaaggga     3565

accgcgggga cggcctttcc cctcccgccc tgtgtgggga cgctgcacga gccgtggacc     3625

aagaggctga caggaggggt ccgcagcgag gaggaggtgc gaagggggcg gcggctccgt     3685

cttgcaggtc ccctggggcg cgttcttcag gtgcgtggtg gacgaggcgg cgtcctcgcg     3745

gggtcgggac ctgggtaccc agcagcatct ggctcctgca tccaccaagg gcgcccaggc     3805

acagcctcag gccagaaggt tcgctgcaga ggttcattct agaaggagcg ggagaccagc     3865

agtcccagcc ctgtccaagg acgcccgctg cttggcacac gagggcgccg caggcccacc     3925

atccctcagg acatggctgc cgagtcccca gagacttctg gtcccacagc aagagctgga     3985

gctccaagca taacatctct aactgtgcgg caaggacagc gcagccagag agaggaagca     4045

gtgcattggt gaaggcaacg ttaggtgtga tttccattcc tgctgggaga cccgggacgc     4105

agcccgggag cttcgtccag cctgtggatg gagcctgact ggctgcagat ggaacttctg     4165

tgtcctccca ccctaggtgg gctaaggttc tgctctcaga gctgaattga caggaggtgt     4225

gtgtgtgtgc tcacttgtgt gcacaagcat gcgtttatgc atgttttcac gcaaccagaa     4285

gagccattcg tgggatttag ccatttcgag gcacctagaa gttgaggcag ccagctgtgc     4345

agccaggtgt gactgttact ggcagcattg tataaaagac acgactcagc tgccgtaggg     4405

aggactgggt tgtctggaag tattaggctc attttatatt tgtgtcagaa gaaatgtctg     4465

actttggggc agatgacacg gtggctgcgg accaggcatg gctccctagg ttgaaatcag     4525

ggaaaagcta atagtatcag acagatatgc tttttctttg gtggctgcag gatttttgct     4585

ggaaaatgca ctattaatca gcacttgtcc aagaaagacc catccatttc tgttgtcatt     4645

caagccacag ttcctgattt actcggcaag atactgggcc agttcagtgt ctctagctga     4705

gcctgacctc ggggtttgcg tctcgagtct gaaatcctgt ttagtcctct gtgcatagtt     4765

ttgtctcatt ttaacgactg catcttcttg gcacatttat tatactcaca actgaatggc     4825

acacaatagc cttgtgttaa taaaagctac cgtggcgctg tgggtgaacc gctgggttga     4885

agtccgatgg actctacgat gcaggcatcc agaaatatgt tgtaactcta cctggctccc     4945

tgccagcctg gcctcctcct ctgggagagc tcctggcatg gtcccaatgt gtacctgcat     5005

gggaacaaca gctgcatggg ccagctgttt cggatctaaa gatgtgcagt gaaactcaca     5065

ttcccagatt cacatccctc atgtttattt gggtcatcat ggtttagcat gttgtatata     5125

tgtctggagc acttcataca cctctatcca ccacagacac tcttaatcac agttctgtaa     5185

taataataag gcaaactata cggcaaagag aagcatgtaa atatgtacca aatccttatg     5245

aagttgtaat tgtttatatg taaaaagtat gtatatagga acgggagaag gtgcaaggaa     5305

tgtgctgaat aacatccaaa ctgcatcgcg tctctgcccc attcctgaaa gcacacatct     5365

agttggagcg tcagttcctc tccttagata tcattgtttt cactcgtcta tcataggcac     5425

cttctttaca tctgattaca atacccagca tttcagaact gggtttttgc ccccaaaaag     5485

gtaaatatga gcatttatca ctgactcctc ctggtccagt gagcagcagc agaattcaag     5545

tatttaaaaa taaggtgcat ttctaaattg caggctatac cttcttttcc aaaccaatgg     5605

gctagagtga atttcctcca agtacttggg ctgtcttact gctagctctt ctaacagggg     5665

aagtctgtat gaatgcatca ccccctaata aggcaagagg aaggaccctg aaatgttgcc     5725

agaaatgtac tgttacatca acatttacat tatattaaca tcatcacact ctgtgttcaa     5785

cacacagaac aacatagata ctttagtttg tctaaagtaa aaatccacat aaatagcaga     5845

ttcctttgtt gacaccagtg tgttgtttac cttgtgccca tggtccagat tttgagctgg     5905

agaaggacta tggctgttcc ttaaagtctc tgcccttgca gaatctgtag ccttcaggat     5965

accccgagtg ccttacaggg cttgtgaaca ccgatactag aagtcaaaaa gaagagagtg     6025

cccaagtgtg ggtttggagg cactgacgca ttcgccaact caccgtcatc ccatccttga     6085

aaccctgaga gagagtgtgt gttttatcac agtaatggaa ttcagtttag cctcaggaaa     6145

ctcatattgt gaatataggt atcaaatcat atatttgttt actgtatatt ttttaaaaag     6205

ctttattgta aatttatgca aaaactaacc gggcctgttt tcttacggcg gcatgccagg     6265

tagtgtgtgt attctcccag gcactccctt catagtcacc ctctaaccac gtgacattcc     6325

gttccatgct aagcagtatt cacaggccta aaataggttt gtatggtgat ctacaagatt     6385

ttacaaatat ttttgtattg tgattcctat gatatatacc agagaatttt ttactcgttt     6445

gtaaattatt gtacagtttt aataaaaaat gttttaaatc tta                       6488


<210>  182
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Ser Lys Arg Gly Met Ser Ser Arg Ala Lys Gly Asp Lys Ala Glu 
1               5                   10                  15      


Ala Leu Ala Ala Leu Gln Ala Ala Asn Glu Asp Leu Arg Ala Lys Leu 
            20                  25                  30          


Thr Asp Ile Gln Ile Glu Leu Gln Gln Glu Lys Ser Lys Val Ser Lys 
        35                  40                  45              


Val Glu Arg Glu Lys Asn Gln Glu Leu Arg Gln Val Arg Glu His Glu 
    50                  55                  60                  


Gln His Lys Thr Ala Val Leu Leu Thr Glu Leu Lys Thr Lys Leu His 
65                  70                  75                  80  


Glu Glu Lys Met Lys Glu Leu Gln Ala Val Arg Glu Thr Leu Leu Arg 
                85                  90                  95      


Gln His Glu Ala Glu Leu Leu Arg Val Ile Lys Ile Lys Asp Asn Glu 
            100                 105                 110         


Asn Gln Arg Leu Gln Ala Leu Leu Ser Ala Leu Arg Asp Gly Gly Pro 
        115                 120                 125             


Glu Lys Val Lys Thr Val Leu Leu Ser Glu Ala Lys Glu Glu Ala Lys 
    130                 135                 140                 


Lys Gly Phe Glu Val Glu Lys Val Lys Met Gln Gln Glu Ile Ser Glu 
145                 150                 155                 160 


Leu Lys Gly Ala Lys Arg Gln Val Glu Glu Ala Leu Thr Leu Val Ile 
                165                 170                 175     


Gln Ala Asp Lys Ile Lys Ala Ala Glu Ile Arg Ser Val Tyr His Leu 
            180                 185                 190         


His Gln Glu Glu Ile Thr Arg Ile Lys Lys Glu Cys Glu Arg Glu Ile 
        195                 200                 205             


Arg Arg Leu Met Glu Glu Ile Lys Phe Lys Asp Arg Ala Val Phe Val 
    210                 215                 220                 


Leu Glu Arg Glu Leu Gly Val Gln Ala Gly His Ala Gln Arg Leu Gln 
225                 230                 235                 240 


Leu Gln Lys Glu Ala Leu Asp Glu Gln Leu Ser Gln Val Arg Glu Ala 
                245                 250                 255     


Asp Arg His Pro Gly Ser Pro Arg Arg Glu Leu Pro His Ala Ala Gly 
            260                 265                 270         


Ala Gly Asp Ala Ser Asp His Ser Gly Ser Pro Glu Gln Gln Leu Asp 
        275                 280                 285             


Glu Lys Asp Ala Arg Arg Phe Gln Leu Lys Ile Ala Glu Leu Ser Ala 
    290                 295                 300                 


Ile Ile Arg Lys Leu Glu Asp Arg Asn Ala Leu Leu Ser Glu Glu Arg 
305                 310                 315                 320 


Asn Glu Leu Leu Lys Arg Val Arg Glu Ala Glu Ser Gln Tyr Lys Pro 
                325                 330                 335     


Leu Leu Asp Lys Asn Lys Arg Leu Ser Arg Lys Asn Glu Asp Leu Ser 
            340                 345                 350         


His Ala Leu Arg Arg Met Glu Asn Lys Leu Lys Phe Val Thr Gln Glu 
        355                 360                 365             


Asn Ile Glu Met Arg Gln Arg Ala Gly Ile Ile Arg Arg Pro Ser Ser 
    370                 375                 380                 


Leu Asn Asp Leu Asp Gln Ser Gln Asp Glu Arg Glu Val Asp Phe Leu 
385                 390                 395                 400 


Lys Leu Gln Ile Val Glu Gln Gln Asn Leu Ile Asp Glu Leu Ser Lys 
                405                 410                 415     


Thr Leu Glu Thr Ala Gly Tyr Val Lys Ser Val Leu Glu Arg Asp Lys 
            420                 425                 430         


Leu Leu Arg Phe Arg Lys Gln Arg Lys Lys Met Ala Lys Leu Pro Lys 
        435                 440                 445             


Pro Val Val Val Glu Thr Phe Phe Gly Tyr Asp Glu Glu Ala Ser Leu 
    450                 455                 460                 


Glu Ser Asp Gly Ser Ser Val Ser Tyr Gln Thr Asp Arg Thr Asp Gln 
465                 470                 475                 480 


Thr Pro Cys Thr Pro Asp Asp Asp Leu Glu Glu Gly Met Ala Lys Glu 
                485                 490                 495     


Glu Thr Glu Leu Arg Phe Arg Gln Leu Thr Met Glu Tyr Gln Ala Leu 
            500                 505                 510         


Gln Arg Ala Tyr Ala Leu Leu Gln Glu Gln Val Gly Gly Thr Leu Asp 
        515                 520                 525             


Ala Glu Arg Glu Val Lys Thr Arg Glu Gln Leu Gln Ala Glu Val Gln 
    530                 535                 540                 


Arg Ala Gln Ala Arg Ile Glu Asp Leu Glu Lys Ala Leu Ala Glu Gln 
545                 550                 555                 560 


Gly Gln Asp Met Lys Trp Ile Glu Glu Lys Gln Ala Leu Tyr Arg Arg 
                565                 570                 575     


Asn Gln Glu Leu Val Glu Lys Ile Lys Gln Met Glu Thr Glu Glu Ala 
            580                 585                 590         


Arg Leu Arg His Glu Val Gln Asp Ala Arg Asp Gln Asn Glu Leu Leu 
        595                 600                 605             


Glu Phe Arg Ile Leu Glu Leu Glu Glu Arg Glu Arg Lys Ser Pro Ala 
    610                 615                 620                 


Ile Ser Phe His His Thr Pro Phe Val Asp Gly Lys Ser Pro Leu Gln 
625                 630                 635                 640 


Val Tyr Cys Glu Ala Glu Gly Val Thr Asp Ile Val Val Ala Glu Leu 
                645                 650                 655     


Met Lys Lys Leu Asp Ile Leu Gly Asp Asn Ala Asn Leu Thr Asn Glu 
            660                 665                 670         


Glu Gln Val Val Val Ile Gln Ala Arg Thr Val Leu Thr Leu Ala Glu 
        675                 680                 685             


Lys Trp Leu Gln Gln Ile Glu Glu Thr Glu Ala Ala Leu Gln Arg Lys 
    690                 695                 700                 


Met Val Asp Leu Glu Ser Glu Lys Glu Leu Phe Ser Lys Gln Lys Gly 
705                 710                 715                 720 


Tyr Leu Asp Glu Glu Leu Asp Tyr Arg Lys Gln Ala Leu Asp Gln Ala 
                725                 730                 735     


Asn Lys His Ile Leu Glu Leu Glu Ala Met Leu Tyr Asp Ala Leu Gln 
            740                 745                 750         


Gln Glu Ala Gly Ala Lys Val Ala Glu Leu Leu Ser Glu Glu Glu Arg 
        755                 760                 765             


Glu Lys Leu Lys Val Ala Val Glu Gln Trp Lys Arg Gln Val Met Ser 
    770                 775                 780                 


Glu Leu Arg Glu Arg Asp Ala Gln Ile Leu Arg Glu Arg Met Glu Leu 
785                 790                 795                 800 


Leu Gln Leu Ala Gln Gln Arg Ile Lys Glu Leu Glu Glu Arg Ile Glu 
                805                 810                 815     


Ala Gln Lys Arg Gln Ile Lys Glu Leu Glu Glu Lys Phe Leu Phe Leu 
            820                 825                 830         


Phe Leu Phe Phe Ser Leu Ala Phe Ile Leu Trp Ser 
        835                 840                 


<210>  183
<211>  1443
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (118)..(1323)

<400>  183
aaccattgtg atggtctaga taagtgtaca tgcttaggcc ttctgaagca gcatttgaag       60

ctgcagtcct gaaaaccatg caggccggaa gagtagataa agaaatattt atttgag         117

atg gca cat gtt tct tca gaa act caa gat gtt tcc ccc aaa gat gaa        165
Met Ala His Val Ser Ser Glu Thr Gln Asp Val Ser Pro Lys Asp Glu           
1               5                   10                  15                

tta act gct tca gaa gcc tcc act agg tct cca ttg tgt gaa cac acc        213
Leu Thr Ala Ser Glu Ala Ser Thr Arg Ser Pro Leu Cys Glu His Thr           
            20                  25                  30                    

ttc cct ggg gac tca gac tta cgg tca atg att gaa gaa cat gct ttt        261
Phe Pro Gly Asp Ser Asp Leu Arg Ser Met Ile Glu Glu His Ala Phe           
        35                  40                  45                        

cag gtt ttg tca caa gga tcc ttg tta gaa agt cca agt tac aca gtt        309
Gln Val Leu Ser Gln Gly Ser Leu Leu Glu Ser Pro Ser Tyr Thr Val           
    50                  55                  60                            

tgt gtc tct gag cca gat aaa gat gat gat ttt ctt tct ctg aac ttt        357
Cys Val Ser Glu Pro Asp Lys Asp Asp Asp Phe Leu Ser Leu Asn Phe           
65                  70                  75                  80            

ccc agg aaa ctt tgg aaa ata gtg gaa agt gac caa ttc aag tct att        405
Pro Arg Lys Leu Trp Lys Ile Val Glu Ser Asp Gln Phe Lys Ser Ile           
                85                  90                  95                

tca tgg gat gag aat gga act tgc ata gtg att aat gaa gaa ctc ttc        453
Ser Trp Asp Glu Asn Gly Thr Cys Ile Val Ile Asn Glu Glu Leu Phe           
            100                 105                 110                   

aag aaa gaa att ttg gaa aca aag gct cct tac aga ata ttt caa act        501
Lys Lys Glu Ile Leu Glu Thr Lys Ala Pro Tyr Arg Ile Phe Gln Thr           
        115                 120                 125                       

gat gct atc aaa agt ttt gtt cga cag ctc aac ctt tat gga ttt agt        549
Asp Ala Ile Lys Ser Phe Val Arg Gln Leu Asn Leu Tyr Gly Phe Ser           
    130                 135                 140                           

aaa att caa cag aat ttt caa aga tct gcc ttt cta gcc acc ttt ctg        597
Lys Ile Gln Gln Asn Phe Gln Arg Ser Ala Phe Leu Ala Thr Phe Leu           
145                 150                 155                 160           

tca gaa gag aaa gaa tcg tct gtc tta agc aag tta aag ttc tat tat        645
Ser Glu Glu Lys Glu Ser Ser Val Leu Ser Lys Leu Lys Phe Tyr Tyr           
                165                 170                 175               

aat cca aat ttc aag cgt ggc tat ccc caa ctt tta gta aga gtg aag        693
Asn Pro Asn Phe Lys Arg Gly Tyr Pro Gln Leu Leu Val Arg Val Lys           
            180                 185                 190                   

aga aga att ggt gtt aaa aat gct tca cct ata tct act tta ttc aac        741
Arg Arg Ile Gly Val Lys Asn Ala Ser Pro Ile Ser Thr Leu Phe Asn           
        195                 200                 205                       

gaa gat ttc aac aag aag cat ttt aga gca ggg gct aac atg gag aat        789
Glu Asp Phe Asn Lys Lys His Phe Arg Ala Gly Ala Asn Met Glu Asn           
    210                 215                 220                           

cat aat tct gcc tta gct gct gaa gct agt gaa gaa agt tta ttt tca        837
His Asn Ser Ala Leu Ala Ala Glu Ala Ser Glu Glu Ser Leu Phe Ser           
225                 230                 235                 240           

gcc tct aaa aat tta aat atg cct cta aca agg gaa tct tct gtc aga        885
Ala Ser Lys Asn Leu Asn Met Pro Leu Thr Arg Glu Ser Ser Val Arg           
                245                 250                 255               

cag ata att gca aat tca tct gtc ccc att aga agt ggt ttc cct cct        933
Gln Ile Ile Ala Asn Ser Ser Val Pro Ile Arg Ser Gly Phe Pro Pro           
            260                 265                 270                   

cct tca cct tca acc tca gtt gga cca tca gaa caa att gca aca gat        981
Pro Ser Pro Ser Thr Ser Val Gly Pro Ser Glu Gln Ile Ala Thr Asp           
        275                 280                 285                       

caa cat gct att tta aat cag ttg acc act att cat atg cac tct cat       1029
Gln His Ala Ile Leu Asn Gln Leu Thr Thr Ile His Met His Ser His           
    290                 295                 300                           

agt acc tac atg caa gca agg ggc cac att gtg aat ttt att aca acc       1077
Ser Thr Tyr Met Gln Ala Arg Gly His Ile Val Asn Phe Ile Thr Thr           
305                 310                 315                 320           

aca act tct caa tac cac atc ata tct ccc tta caa aat ggt tat ttt       1125
Thr Thr Ser Gln Tyr His Ile Ile Ser Pro Leu Gln Asn Gly Tyr Phe           
                325                 330                 335               

ggg ctg aca gtg gaa cca tct gct gtt ccc aca cga tat cct ctg gta       1173
Gly Leu Thr Val Glu Pro Ser Ala Val Pro Thr Arg Tyr Pro Leu Val           
            340                 345                 350                   

tca gtc aat gag gct cca tat cgt aac atg cta cca gca ggc aac ccg       1221
Ser Val Asn Glu Ala Pro Tyr Arg Asn Met Leu Pro Ala Gly Asn Pro           
        355                 360                 365                       

tgg ttg caa atg cct acg atc gct gat aga tca gct gcc cct cat tcc       1269
Trp Leu Gln Met Pro Thr Ile Ala Asp Arg Ser Ala Ala Pro His Ser           
    370                 375                 380                           

agg cta gct ctt caa cca tca cca ctg gac aaa tat cac cct aat tac       1317
Arg Leu Ala Leu Gln Pro Ser Pro Leu Asp Lys Tyr His Pro Asn Tyr           
385                 390                 395                 400           

aac tga tctgccatta aaagaggacc agattatgaa tgacaacaga gactaacatt        1373
Asn                                                                       
                                                                          

tacattgaca aaaaacccta aaaatttctg caattatctt attgaacaat aaaattgcat     1433

gtttacttct                                                            1443


<210>  184
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Ala His Val Ser Ser Glu Thr Gln Asp Val Ser Pro Lys Asp Glu 
1               5                   10                  15      


Leu Thr Ala Ser Glu Ala Ser Thr Arg Ser Pro Leu Cys Glu His Thr 
            20                  25                  30          


Phe Pro Gly Asp Ser Asp Leu Arg Ser Met Ile Glu Glu His Ala Phe 
        35                  40                  45              


Gln Val Leu Ser Gln Gly Ser Leu Leu Glu Ser Pro Ser Tyr Thr Val 
    50                  55                  60                  


Cys Val Ser Glu Pro Asp Lys Asp Asp Asp Phe Leu Ser Leu Asn Phe 
65                  70                  75                  80  


Pro Arg Lys Leu Trp Lys Ile Val Glu Ser Asp Gln Phe Lys Ser Ile 
                85                  90                  95      


Ser Trp Asp Glu Asn Gly Thr Cys Ile Val Ile Asn Glu Glu Leu Phe 
            100                 105                 110         


Lys Lys Glu Ile Leu Glu Thr Lys Ala Pro Tyr Arg Ile Phe Gln Thr 
        115                 120                 125             


Asp Ala Ile Lys Ser Phe Val Arg Gln Leu Asn Leu Tyr Gly Phe Ser 
    130                 135                 140                 


Lys Ile Gln Gln Asn Phe Gln Arg Ser Ala Phe Leu Ala Thr Phe Leu 
145                 150                 155                 160 


Ser Glu Glu Lys Glu Ser Ser Val Leu Ser Lys Leu Lys Phe Tyr Tyr 
                165                 170                 175     


Asn Pro Asn Phe Lys Arg Gly Tyr Pro Gln Leu Leu Val Arg Val Lys 
            180                 185                 190         


Arg Arg Ile Gly Val Lys Asn Ala Ser Pro Ile Ser Thr Leu Phe Asn 
        195                 200                 205             


Glu Asp Phe Asn Lys Lys His Phe Arg Ala Gly Ala Asn Met Glu Asn 
    210                 215                 220                 


His Asn Ser Ala Leu Ala Ala Glu Ala Ser Glu Glu Ser Leu Phe Ser 
225                 230                 235                 240 


Ala Ser Lys Asn Leu Asn Met Pro Leu Thr Arg Glu Ser Ser Val Arg 
                245                 250                 255     


Gln Ile Ile Ala Asn Ser Ser Val Pro Ile Arg Ser Gly Phe Pro Pro 
            260                 265                 270         


Pro Ser Pro Ser Thr Ser Val Gly Pro Ser Glu Gln Ile Ala Thr Asp 
        275                 280                 285             


Gln His Ala Ile Leu Asn Gln Leu Thr Thr Ile His Met His Ser His 
    290                 295                 300                 


Ser Thr Tyr Met Gln Ala Arg Gly His Ile Val Asn Phe Ile Thr Thr 
305                 310                 315                 320 


Thr Thr Ser Gln Tyr His Ile Ile Ser Pro Leu Gln Asn Gly Tyr Phe 
                325                 330                 335     


Gly Leu Thr Val Glu Pro Ser Ala Val Pro Thr Arg Tyr Pro Leu Val 
            340                 345                 350         


Ser Val Asn Glu Ala Pro Tyr Arg Asn Met Leu Pro Ala Gly Asn Pro 
        355                 360                 365             


Trp Leu Gln Met Pro Thr Ile Ala Asp Arg Ser Ala Ala Pro His Ser 
    370                 375                 380                 


Arg Leu Ala Leu Gln Pro Ser Pro Leu Asp Lys Tyr His Pro Asn Tyr 
385                 390                 395                 400 


Asn 
    


<210>  185
<211>  3537
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (328)..(2448)

<400>  185
ggcccctcga gcctcgaacc ggaacctcca aatccgagac gctctgctta tgaggacctc       60

gaaatatgcc ggccagtgaa aaaatcttgt ggctttgagg gcttttggtt ggccaggggc      120

agtaaaaatc tcggagagct gacaccaagt cctcccctgc cacgtagcag tggtaaagtc      180

cgaagctcaa attccgagaa ttgagctctg ttgattctta gaactggggt tcttagaagt      240

ggtgatgcaa gaagtttcta ggaaaggccg gacaccaggt tttgagcaaa attttggact      300

gtgaagcaag gcattggtga agacaaa atg gcc tcg ccg gct gac agc tgt atc      354
                              Met Ala Ser Pro Ala Asp Ser Cys Ile         
                              1               5                           

cag ttc acc cgc cat gcc agt gat gtt ctt ctc aac ctt aat cgt ctc        402
Gln Phe Thr Arg His Ala Ser Asp Val Leu Leu Asn Leu Asn Arg Leu           
10                  15                  20                  25            

cgg agt cga gac atc ttg act gat gtt gtc att gtt gtg agc cgt gag        450
Arg Ser Arg Asp Ile Leu Thr Asp Val Val Ile Val Val Ser Arg Glu           
                30                  35                  40                

cag ttt aga gcc cat aaa acg gtc ctc atg gcc tgc agt ggc ctg ttc        498
Gln Phe Arg Ala His Lys Thr Val Leu Met Ala Cys Ser Gly Leu Phe           
            45                  50                  55                    

tat agc atc ttt aca gac cag ttg aaa tgc aac ctt agt gtg atc aat        546
Tyr Ser Ile Phe Thr Asp Gln Leu Lys Cys Asn Leu Ser Val Ile Asn           
        60                  65                  70                        

cta gat cct gag atc aac cct gag gga ttc tgc atc ctc ctg gac ttc        594
Leu Asp Pro Glu Ile Asn Pro Glu Gly Phe Cys Ile Leu Leu Asp Phe           
    75                  80                  85                            

atg tac aca tct cgg ctc aat ttg cgg gag ggc aac atc atg gct gtg        642
Met Tyr Thr Ser Arg Leu Asn Leu Arg Glu Gly Asn Ile Met Ala Val           
90                  95                  100                 105           

atg gcc acg gct atg tac ctg cag atg gag cat gtt gtg gac act tgc        690
Met Ala Thr Ala Met Tyr Leu Gln Met Glu His Val Val Asp Thr Cys           
                110                 115                 120               

cgg aag ttt att aag gcc agt gaa gca gag atg gtt tct gcc atc aag        738
Arg Lys Phe Ile Lys Ala Ser Glu Ala Glu Met Val Ser Ala Ile Lys           
            125                 130                 135                   

cct cct cgt gaa gag ttc ctc aac agc cgg atg ctg atg ccc caa gac        786
Pro Pro Arg Glu Glu Phe Leu Asn Ser Arg Met Leu Met Pro Gln Asp           
        140                 145                 150                       

atc atg gcc tat cgg ggt cgt gag gtg gtg gag aac aac ctg cca ctg        834
Ile Met Ala Tyr Arg Gly Arg Glu Val Val Glu Asn Asn Leu Pro Leu           
    155                 160                 165                           

agg agc gcc cct ggg tgt gag agc aga gcc ttt gcc ccc agc ctg tac        882
Arg Ser Ala Pro Gly Cys Glu Ser Arg Ala Phe Ala Pro Ser Leu Tyr           
170                 175                 180                 185           

agt ggc ctg tcc aca ccg cca gcc tct tat tcc atg tac agc cac ctc        930
Ser Gly Leu Ser Thr Pro Pro Ala Ser Tyr Ser Met Tyr Ser His Leu           
                190                 195                 200               

cct gtc agc agc ctc ctc ttc tcc gat gag gag ttt cgg gat gtc cgg        978
Pro Val Ser Ser Leu Leu Phe Ser Asp Glu Glu Phe Arg Asp Val Arg           
            205                 210                 215                   

atg cct gtg gcc aac ccc ttc ccc aag gag cgg gca ctc cca tgt gat       1026
Met Pro Val Ala Asn Pro Phe Pro Lys Glu Arg Ala Leu Pro Cys Asp           
        220                 225                 230                       

agt gcc agg cca gtc cct ggt gag tac agc cgg ccg act ttg gag gtg       1074
Ser Ala Arg Pro Val Pro Gly Glu Tyr Ser Arg Pro Thr Leu Glu Val           
    235                 240                 245                           

tcc ccc aat gtg tgc cac agc aat atc tat tca ccc aag gaa aca atc       1122
Ser Pro Asn Val Cys His Ser Asn Ile Tyr Ser Pro Lys Glu Thr Ile           
250                 255                 260                 265           

cca gaa gag gca cga agt gat atg cac tac agt gtg gct gag ggc ctc       1170
Pro Glu Glu Ala Arg Ser Asp Met His Tyr Ser Val Ala Glu Gly Leu           
                270                 275                 280               

aaa cct gct gcc ccc tca gcc cga aat gcc ccc tac ttc cct tgt gac       1218
Lys Pro Ala Ala Pro Ser Ala Arg Asn Ala Pro Tyr Phe Pro Cys Asp           
            285                 290                 295                   

aag gcc agc aaa gaa gaa gag aga ccc tcc tcg gaa gat gag att gcc       1266
Lys Ala Ser Lys Glu Glu Glu Arg Pro Ser Ser Glu Asp Glu Ile Ala           
        300                 305                 310                       

ctg cat ttc gag ccc ccc aat gca ccc ctg aac cgg aag ggt ctg gtt       1314
Leu His Phe Glu Pro Pro Asn Ala Pro Leu Asn Arg Lys Gly Leu Val           
    315                 320                 325                           

agt cca cag agc ccc cag aaa tct gac tgc cag ccc aac tcg ccc aca       1362
Ser Pro Gln Ser Pro Gln Lys Ser Asp Cys Gln Pro Asn Ser Pro Thr           
330                 335                 340                 345           

gag tcc tgc agc agt aag aat gcc tgc atc ctc cag gct tct ggc tcc       1410
Glu Ser Cys Ser Ser Lys Asn Ala Cys Ile Leu Gln Ala Ser Gly Ser           
                350                 355                 360               

cct cca gcc aag agc ccc act gac ccc aaa gcc tgc aac tgg aag aaa       1458
Pro Pro Ala Lys Ser Pro Thr Asp Pro Lys Ala Cys Asn Trp Lys Lys           
            365                 370                 375                   

tac aag ttc atc gtg ctc aac agc ctc aac cag aat gcc aaa cca gag       1506
Tyr Lys Phe Ile Val Leu Asn Ser Leu Asn Gln Asn Ala Lys Pro Glu           
        380                 385                 390                       

ggg cct gag cag gct gag ctg ggc cgc ctt tcc cca cga gcc tac acg       1554
Gly Pro Glu Gln Ala Glu Leu Gly Arg Leu Ser Pro Arg Ala Tyr Thr           
    395                 400                 405                           

gcc cca cct gcc tgc cag cca ccc atg gag cct gag aac ctt gac ctc       1602
Ala Pro Pro Ala Cys Gln Pro Pro Met Glu Pro Glu Asn Leu Asp Leu           
410                 415                 420                 425           

cag tcc cca acc aag ctg agt gcc agc ggg gag gac tcc acc atc cca       1650
Gln Ser Pro Thr Lys Leu Ser Ala Ser Gly Glu Asp Ser Thr Ile Pro           
                430                 435                 440               

caa gcc agc cgg ctc aat aac atc gtt aac agg tcc atg acg ggc tct       1698
Gln Ala Ser Arg Leu Asn Asn Ile Val Asn Arg Ser Met Thr Gly Ser           
            445                 450                 455                   

ccc cgc agc agc agc gag agc cac tca cca ctc tac atg cac ccc ccg       1746
Pro Arg Ser Ser Ser Glu Ser His Ser Pro Leu Tyr Met His Pro Pro           
        460                 465                 470                       

aag tgc acg tcc tgc ggc tct cag tcc cca cag cat gca gag atg tgc       1794
Lys Cys Thr Ser Cys Gly Ser Gln Ser Pro Gln His Ala Glu Met Cys           
    475                 480                 485                           

ctc cac acc gct ggc ccc acg ttc cct gag gag atg gga gag acc cag       1842
Leu His Thr Ala Gly Pro Thr Phe Pro Glu Glu Met Gly Glu Thr Gln           
490                 495                 500                 505           

tct gag tac tca gat tct agc tgt gag aac ggg gcc ttc ttc tgc aat       1890
Ser Glu Tyr Ser Asp Ser Ser Cys Glu Asn Gly Ala Phe Phe Cys Asn           
                510                 515                 520               

gag tgt gac tgc cgc ttc tct gag gag gcc tca ctc aag agg cac acg       1938
Glu Cys Asp Cys Arg Phe Ser Glu Glu Ala Ser Leu Lys Arg His Thr           
            525                 530                 535                   

ctg cag acc cac agt gac aaa ccc tac aag tgt gac cgc tgc cag gcc       1986
Leu Gln Thr His Ser Asp Lys Pro Tyr Lys Cys Asp Arg Cys Gln Ala           
        540                 545                 550                       

tcc ttc cgc tac aag ggc aac ctc gcc agc cac aag acc gtc cat acc       2034
Ser Phe Arg Tyr Lys Gly Asn Leu Ala Ser His Lys Thr Val His Thr           
    555                 560                 565                           

ggt gag aaa ccc tat cgt tgc aac atc tgt ggg gcc cag ttc aac cgg       2082
Gly Glu Lys Pro Tyr Arg Cys Asn Ile Cys Gly Ala Gln Phe Asn Arg           
570                 575                 580                 585           

cca gcc aac ctg aaa acc cac act cga att cac tct gga gag aag ccc       2130
Pro Ala Asn Leu Lys Thr His Thr Arg Ile His Ser Gly Glu Lys Pro           
                590                 595                 600               

tac aaa tgc gaa acc tgc gga gcc aga ttt gta cag gtg gcc cac ctc       2178
Tyr Lys Cys Glu Thr Cys Gly Ala Arg Phe Val Gln Val Ala His Leu           
            605                 610                 615                   

cgt gcc cat gtg ctt atc cac act ggt gag aag ccc tat ccc tgt gaa       2226
Arg Ala His Val Leu Ile His Thr Gly Glu Lys Pro Tyr Pro Cys Glu           
        620                 625                 630                       

atc tgt ggc acc cgt ttc cgg cac ctt cag act ctg aag agc cac ctg       2274
Ile Cys Gly Thr Arg Phe Arg His Leu Gln Thr Leu Lys Ser His Leu           
    635                 640                 645                           

cga atc cac aca gga gag aaa cct tac cat tgt gag aag tgt aac ctg       2322
Arg Ile His Thr Gly Glu Lys Pro Tyr His Cys Glu Lys Cys Asn Leu           
650                 655                 660                 665           

cat ttc cgt cac aaa agc cag ctg cga ctt cac ttg cgc cag aag cat       2370
His Phe Arg His Lys Ser Gln Leu Arg Leu His Leu Arg Gln Lys His           
                670                 675                 680               

ggc gcc atc acc aac acc aag gtg caa tac cgc gtg tca gcc act gac       2418
Gly Ala Ile Thr Asn Thr Lys Val Gln Tyr Arg Val Ser Ala Thr Asp           
            685                 690                 695                   

ctg cct ccg gag ctc ccc aaa gcc tgc tga agcatggagt gttgatgctt         2468
Leu Pro Pro Glu Leu Pro Lys Ala Cys                                       
        700                 705                                           

tcgtctccag ccccttctca gaatctaccc aaaggatact gtaacacttt acaatgttca     2528

tcccatgatg tagtgcctct ttcatccact agtgcaaatc atagctgggg gttgggggtg     2588

gtgggggtcg gggcctgggg gactgggagc cgcagcagct ccccctcccc cactgccata     2648

aaacattaag aaaatcatat tgcttcttct cctatgtgta aggtgaacca tgtcagcaaa     2708

aagcaaaatc attttatatg tcaaagcagg ggagtatgca aaagttctga cttgacttta     2768

gtctgcaaaa tgaggaatgt atatgttttg tgggaacaga tgtttctttt gtatgtaaat     2828

gtgcattctt ttaaaagaca agacttcagt atgttgtcaa agagagggct ttaatttttt     2888

taaccaaagg tgaaggaata tatggcagag ttgtaaatat ataaatatat atatatataa     2948

aataaatata tataaaccta aaaaagatat attaaaaata taaaactgcg ttaaaggctc     3008

gattttgtat ctgcaggcag acacggatct gagaatcttt attgagaaag agcacttaag     3068

agaatatttt aagtattgca tctgtataag taagaaaata ttttgtctaa aatgcctcag     3128

tgtatttgta tttttttgca agtgaaggtt tacaatttac aaagtgtgta ttaaaaaaaa     3188

caaaaagaac aaaaaaatct gcagaaggaa aaatgtgtaa ttttgttcta gttttcagtt     3248

tgtatatacc cgtacaacgt gtcctcacgg tgcctttttt cacggaagtt ttcaatgatg     3308

ggcgagcgtg caccatccct ttttgaagtg taggcagaca cagggacttg aagttgttac     3368

taactaaact ctctttggga atgtttgtct catcccattc tgcgtcatgc ttgtgttata     3428

actactccgg agacagggtt tggctgtgtc taaactgcat taccgcgttg taaaatatag     3488

ctgtacaaat ataagaataa aatgttgaaa agtcaaactg gaaaaaaaa                 3537


<210>  186
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Ala Ser Pro Ala Asp Ser Cys Ile Gln Phe Thr Arg His Ala Ser 
1               5                   10                  15      


Asp Val Leu Leu Asn Leu Asn Arg Leu Arg Ser Arg Asp Ile Leu Thr 
            20                  25                  30          


Asp Val Val Ile Val Val Ser Arg Glu Gln Phe Arg Ala His Lys Thr 
        35                  40                  45              


Val Leu Met Ala Cys Ser Gly Leu Phe Tyr Ser Ile Phe Thr Asp Gln 
    50                  55                  60                  


Leu Lys Cys Asn Leu Ser Val Ile Asn Leu Asp Pro Glu Ile Asn Pro 
65                  70                  75                  80  


Glu Gly Phe Cys Ile Leu Leu Asp Phe Met Tyr Thr Ser Arg Leu Asn 
                85                  90                  95      


Leu Arg Glu Gly Asn Ile Met Ala Val Met Ala Thr Ala Met Tyr Leu 
            100                 105                 110         


Gln Met Glu His Val Val Asp Thr Cys Arg Lys Phe Ile Lys Ala Ser 
        115                 120                 125             


Glu Ala Glu Met Val Ser Ala Ile Lys Pro Pro Arg Glu Glu Phe Leu 
    130                 135                 140                 


Asn Ser Arg Met Leu Met Pro Gln Asp Ile Met Ala Tyr Arg Gly Arg 
145                 150                 155                 160 


Glu Val Val Glu Asn Asn Leu Pro Leu Arg Ser Ala Pro Gly Cys Glu 
                165                 170                 175     


Ser Arg Ala Phe Ala Pro Ser Leu Tyr Ser Gly Leu Ser Thr Pro Pro 
            180                 185                 190         


Ala Ser Tyr Ser Met Tyr Ser His Leu Pro Val Ser Ser Leu Leu Phe 
        195                 200                 205             


Ser Asp Glu Glu Phe Arg Asp Val Arg Met Pro Val Ala Asn Pro Phe 
    210                 215                 220                 


Pro Lys Glu Arg Ala Leu Pro Cys Asp Ser Ala Arg Pro Val Pro Gly 
225                 230                 235                 240 


Glu Tyr Ser Arg Pro Thr Leu Glu Val Ser Pro Asn Val Cys His Ser 
                245                 250                 255     


Asn Ile Tyr Ser Pro Lys Glu Thr Ile Pro Glu Glu Ala Arg Ser Asp 
            260                 265                 270         


Met His Tyr Ser Val Ala Glu Gly Leu Lys Pro Ala Ala Pro Ser Ala 
        275                 280                 285             


Arg Asn Ala Pro Tyr Phe Pro Cys Asp Lys Ala Ser Lys Glu Glu Glu 
    290                 295                 300                 


Arg Pro Ser Ser Glu Asp Glu Ile Ala Leu His Phe Glu Pro Pro Asn 
305                 310                 315                 320 


Ala Pro Leu Asn Arg Lys Gly Leu Val Ser Pro Gln Ser Pro Gln Lys 
                325                 330                 335     


Ser Asp Cys Gln Pro Asn Ser Pro Thr Glu Ser Cys Ser Ser Lys Asn 
            340                 345                 350         


Ala Cys Ile Leu Gln Ala Ser Gly Ser Pro Pro Ala Lys Ser Pro Thr 
        355                 360                 365             


Asp Pro Lys Ala Cys Asn Trp Lys Lys Tyr Lys Phe Ile Val Leu Asn 
    370                 375                 380                 


Ser Leu Asn Gln Asn Ala Lys Pro Glu Gly Pro Glu Gln Ala Glu Leu 
385                 390                 395                 400 


Gly Arg Leu Ser Pro Arg Ala Tyr Thr Ala Pro Pro Ala Cys Gln Pro 
                405                 410                 415     


Pro Met Glu Pro Glu Asn Leu Asp Leu Gln Ser Pro Thr Lys Leu Ser 
            420                 425                 430         


Ala Ser Gly Glu Asp Ser Thr Ile Pro Gln Ala Ser Arg Leu Asn Asn 
        435                 440                 445             


Ile Val Asn Arg Ser Met Thr Gly Ser Pro Arg Ser Ser Ser Glu Ser 
    450                 455                 460                 


His Ser Pro Leu Tyr Met His Pro Pro Lys Cys Thr Ser Cys Gly Ser 
465                 470                 475                 480 


Gln Ser Pro Gln His Ala Glu Met Cys Leu His Thr Ala Gly Pro Thr 
                485                 490                 495     


Phe Pro Glu Glu Met Gly Glu Thr Gln Ser Glu Tyr Ser Asp Ser Ser 
            500                 505                 510         


Cys Glu Asn Gly Ala Phe Phe Cys Asn Glu Cys Asp Cys Arg Phe Ser 
        515                 520                 525             


Glu Glu Ala Ser Leu Lys Arg His Thr Leu Gln Thr His Ser Asp Lys 
    530                 535                 540                 


Pro Tyr Lys Cys Asp Arg Cys Gln Ala Ser Phe Arg Tyr Lys Gly Asn 
545                 550                 555                 560 


Leu Ala Ser His Lys Thr Val His Thr Gly Glu Lys Pro Tyr Arg Cys 
                565                 570                 575     


Asn Ile Cys Gly Ala Gln Phe Asn Arg Pro Ala Asn Leu Lys Thr His 
            580                 585                 590         


Thr Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Thr Cys Gly 
        595                 600                 605             


Ala Arg Phe Val Gln Val Ala His Leu Arg Ala His Val Leu Ile His 
    610                 615                 620                 


Thr Gly Glu Lys Pro Tyr Pro Cys Glu Ile Cys Gly Thr Arg Phe Arg 
625                 630                 635                 640 


His Leu Gln Thr Leu Lys Ser His Leu Arg Ile His Thr Gly Glu Lys 
                645                 650                 655     


Pro Tyr His Cys Glu Lys Cys Asn Leu His Phe Arg His Lys Ser Gln 
            660                 665                 670         


Leu Arg Leu His Leu Arg Gln Lys His Gly Ala Ile Thr Asn Thr Lys 
        675                 680                 685             


Val Gln Tyr Arg Val Ser Ala Thr Asp Leu Pro Pro Glu Leu Pro Lys 
    690                 695                 700                 


Ala Cys 
705     


<210>  187
<211>  2072
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (54)..(944)

<400>  187
cgccgtgccc gcggagagag cgcggcgcgg gaggccggcg gccggccggc tgc atg          56
                                                           Met            
                                                           1              

gcg cgc tgc gag agg ctg cgc gga gcg gcc ctg cgc gac gtg ctg ggc        104
Ala Arg Cys Glu Arg Leu Arg Gly Ala Ala Leu Arg Asp Val Leu Gly           
            5                   10                  15                    

cgg gcg cag ggg gtc ctg ttc gac tgt gac ggg gtg ctg tgg aac ggc        152
Arg Ala Gln Gly Val Leu Phe Asp Cys Asp Gly Val Leu Trp Asn Gly           
        20                  25                  30                        

gag cgc gcc gtg ccg ggc gcc ccg gag ctg ctg gag cgg ctg gcg cgg        200
Glu Arg Ala Val Pro Gly Ala Pro Glu Leu Leu Glu Arg Leu Ala Arg           
    35                  40                  45                            

gcc ggc aag gcg gct ctg ttt gtg agc aac aac agc cgg cgc gcg cgg        248
Ala Gly Lys Ala Ala Leu Phe Val Ser Asn Asn Ser Arg Arg Ala Arg           
50                  55                  60                  65            

ccc gag ctg gcc ctg cgc ttc gcg cgc ctc ggc ttc ggg ggg ctg cgc        296
Pro Glu Leu Ala Leu Arg Phe Ala Arg Leu Gly Phe Gly Gly Leu Arg           
                70                  75                  80                

gcc gag cag ctc ttc agc tcc gcg ctg tgc gcc gcg cgc ctg ctg cgc        344
Ala Glu Gln Leu Phe Ser Ser Ala Leu Cys Ala Ala Arg Leu Leu Arg           
            85                  90                  95                    

cag cgc ctg ccc ggg cct ccg gac gcg ccg ggc gcc gtg ttc gtg ctg        392
Gln Arg Leu Pro Gly Pro Pro Asp Ala Pro Gly Ala Val Phe Val Leu           
        100                 105                 110                       

ggc ggc gag ggg ctg cgc gcc gag ctg cgc gcc gcg ggg ctg cgc ctg        440
Gly Gly Glu Gly Leu Arg Ala Glu Leu Arg Ala Ala Gly Leu Arg Leu           
    115                 120                 125                           

gcc ggg gac ccg agc gcg ggg gac ggc gcg gcc ccg cgc gtg cgc gcc        488
Ala Gly Asp Pro Ser Ala Gly Asp Gly Ala Ala Pro Arg Val Arg Ala           
130                 135                 140                 145           

gtg ctt gtg ggc tac gac gag cac ttc tcc ttc gcc aag ctg agg gag        536
Val Leu Val Gly Tyr Asp Glu His Phe Ser Phe Ala Lys Leu Arg Glu           
                150                 155                 160               

gcg tgc gcg cac ctg cgc gac ccc gag tgc cta ctc gtg gcc acc gac        584
Ala Cys Ala His Leu Arg Asp Pro Glu Cys Leu Leu Val Ala Thr Asp           
            165                 170                 175                   

cgt gac cca tgg cac ccg ctg agc gac ggc agc cgg acc cct ggc acc        632
Arg Asp Pro Trp His Pro Leu Ser Asp Gly Ser Arg Thr Pro Gly Thr           
        180                 185                 190                       

ggg agc ctg gcc gct gca gtg gag aca gcc tcg gga cgc cag gcc ctg        680
Gly Ser Leu Ala Ala Ala Val Glu Thr Ala Ser Gly Arg Gln Ala Leu           
    195                 200                 205                           

gtg gtg ggc aag ccc agc ccc tac atg ttc gag tgc atc acg gag aac        728
Val Val Gly Lys Pro Ser Pro Tyr Met Phe Glu Cys Ile Thr Glu Asn           
210                 215                 220                 225           

ttc agc atc gac ccc gca cgc acg ctt atg gtg ggt gac cgc ctg gag        776
Phe Ser Ile Asp Pro Ala Arg Thr Leu Met Val Gly Asp Arg Leu Glu           
                230                 235                 240               

acc gac atc ctc ttt ggc cac cgc tgc ggc atg acc act gtg ctc acg        824
Thr Asp Ile Leu Phe Gly His Arg Cys Gly Met Thr Thr Val Leu Thr           
            245                 250                 255                   

ctc aca gga gtc tcc cgc cta gaa gag gcc cag gcc tac cta gcg gcc        872
Leu Thr Gly Val Ser Arg Leu Glu Glu Ala Gln Ala Tyr Leu Ala Ala           
        260                 265                 270                       

ggc cag cac gac ctc gtg ccc cat tac tat gtg gag agc atc gca gac        920
Gly Gln His Asp Leu Val Pro His Tyr Tyr Val Glu Ser Ile Ala Asp           
    275                 280                 285                           

ttg aca gag ggg ttg gag gac tga gcccactgca cctgcagcca caggcccacc       974
Leu Thr Glu Gly Leu Glu Asp                                               
290                 295                                                   

cctccccact ccctgatccc gtaggtggag gcgatgggtc acgagccatg ttaagcacaa     1034

ccggctcctt ggtccagttc tgcaccgggg tggggctggg acccggggaa ggtttgaggg     1094

cccttgcaac cccctcccag cagtggctgg gcactctttg ctgccccaga agctggtccc     1154

ctatggattc atcttggcct gacccagcca ggtggcctta tttcttccct gtcacctccc     1214

ctccttgaaa tctgggccct ggtgcctgct gaagattccc tctatccctg agtacttagt     1274

cttctccccc ttccctgggg cttctagagc tctctctgcc cctcaggtcc tggcccttgg     1334

gtccttgtca accagaggtc tagggaacca caacccttat tgtcctgggt ggaccaatcc     1394

aaaggctaag tgatagtgac tcatcaatgt tgggtcctgt ggggtaccag tttaggttcc     1454

taagtaatag tgaccctttc acgtcctgga gcccgagtgg accaatcgga agcctaagtg     1514

acgatgaccc tcgcatgtcc taggtccctg ggtggaccca tcaggacccc aagtgatagt     1574

gacccagtgg tcttttagat cctcagtaga acagtccaga agcctgagag acagtggccc     1634

cttgataatc tgggtctcac gggaccagct aggggtccag gtttcagtca gtaaataaga     1694

gtggtccacg tcctaaagac acctctcctt tacaaagact tgtgatgctc tggggcttct     1754

gtggccaagc cccacccttt cctggtcatg gtacccgtac agcgttgatg gccacagctc     1814

gaaggggggc tttcgtgtcc ccctgtgcgg tcagtgtttt cagtaccacc tctctcccgt     1874

gcccacttgg ctatttactt atttatttat tgtgtgccag tgatggtggg tgggggctgg     1934

gccttccccg ccacctccac ccctgttgtg acctgtcctt ccgtacttaa taaagtgcgc     1994

gtgggagtgt taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2054

aaaaaaaaaa aaaaaaaa                                                   2072


<210>  188
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Ala Arg Cys Glu Arg Leu Arg Gly Ala Ala Leu Arg Asp Val Leu 
1               5                   10                  15      


Gly Arg Ala Gln Gly Val Leu Phe Asp Cys Asp Gly Val Leu Trp Asn 
            20                  25                  30          


Gly Glu Arg Ala Val Pro Gly Ala Pro Glu Leu Leu Glu Arg Leu Ala 
        35                  40                  45              


Arg Ala Gly Lys Ala Ala Leu Phe Val Ser Asn Asn Ser Arg Arg Ala 
    50                  55                  60                  


Arg Pro Glu Leu Ala Leu Arg Phe Ala Arg Leu Gly Phe Gly Gly Leu 
65                  70                  75                  80  


Arg Ala Glu Gln Leu Phe Ser Ser Ala Leu Cys Ala Ala Arg Leu Leu 
                85                  90                  95      


Arg Gln Arg Leu Pro Gly Pro Pro Asp Ala Pro Gly Ala Val Phe Val 
            100                 105                 110         


Leu Gly Gly Glu Gly Leu Arg Ala Glu Leu Arg Ala Ala Gly Leu Arg 
        115                 120                 125             


Leu Ala Gly Asp Pro Ser Ala Gly Asp Gly Ala Ala Pro Arg Val Arg 
    130                 135                 140                 


Ala Val Leu Val Gly Tyr Asp Glu His Phe Ser Phe Ala Lys Leu Arg 
145                 150                 155                 160 


Glu Ala Cys Ala His Leu Arg Asp Pro Glu Cys Leu Leu Val Ala Thr 
                165                 170                 175     


Asp Arg Asp Pro Trp His Pro Leu Ser Asp Gly Ser Arg Thr Pro Gly 
            180                 185                 190         


Thr Gly Ser Leu Ala Ala Ala Val Glu Thr Ala Ser Gly Arg Gln Ala 
        195                 200                 205             


Leu Val Val Gly Lys Pro Ser Pro Tyr Met Phe Glu Cys Ile Thr Glu 
    210                 215                 220                 


Asn Phe Ser Ile Asp Pro Ala Arg Thr Leu Met Val Gly Asp Arg Leu 
225                 230                 235                 240 


Glu Thr Asp Ile Leu Phe Gly His Arg Cys Gly Met Thr Thr Val Leu 
                245                 250                 255     


Thr Leu Thr Gly Val Ser Arg Leu Glu Glu Ala Gln Ala Tyr Leu Ala 
            260                 265                 270         


Ala Gly Gln His Asp Leu Val Pro His Tyr Tyr Val Glu Ser Ile Ala 
        275                 280                 285             


Asp Leu Thr Glu Gly Leu Glu Asp 
    290                 295     


<210>  189
<211>  2102
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (81)..(1181)

<400>  189
acacccagct gcctgagacc ctccttcaac ctccctagag gacagcccca ctctgcctcc       60

tgctccccca gggcagcacc atg tgg ccc ctg tgg ctc tgc tgg gca ctc tgg      113
                      Met Trp Pro Leu Trp Leu Cys Trp Ala Leu Trp         
                      1               5                   10              

gtg ctg ccc ctg gct ggc ccc ggg gcg gcc ctg acc gag gag cag ctc        161
Val Leu Pro Leu Ala Gly Pro Gly Ala Ala Leu Thr Glu Glu Gln Leu           
            15                  20                  25                    

ctg ggc agc ctg ctg cgg cag ctg cag ctc agc gag gtg ccc gta ctg        209
Leu Gly Ser Leu Leu Arg Gln Leu Gln Leu Ser Glu Val Pro Val Leu           
        30                  35                  40                        

gac agg gcc gac atg gag aag ctg gtc atc ccc gcc cac gtg agg gcc        257
Asp Arg Ala Asp Met Glu Lys Leu Val Ile Pro Ala His Val Arg Ala           
    45                  50                  55                            

cag tat gta gtc ctg ctg cgg cgc agc cac ggg gac cgc tcc cgc gga        305
Gln Tyr Val Val Leu Leu Arg Arg Ser His Gly Asp Arg Ser Arg Gly           
60                  65                  70                  75            

aag agg ttc agc cag agc ttc cga gag gtg gcc ggc agg ttc ctg gcg        353
Lys Arg Phe Ser Gln Ser Phe Arg Glu Val Ala Gly Arg Phe Leu Ala           
                80                  85                  90                

tcg gag gcc agc aca cac ctg ctg gtg ttc ggc atg gag cag cgg ctg        401
Ser Glu Ala Ser Thr His Leu Leu Val Phe Gly Met Glu Gln Arg Leu           
            95                  100                 105                   

ccg ccc aac agc gag ctg gtg cag gcc gtg ctg cgg ctc ttc cag gag        449
Pro Pro Asn Ser Glu Leu Val Gln Ala Val Leu Arg Leu Phe Gln Glu           
        110                 115                 120                       

ccg gtc ccc aag gcc gcg ctg cac agg cac ggg cgg ctg tcc ccg cgc        497
Pro Val Pro Lys Ala Ala Leu His Arg His Gly Arg Leu Ser Pro Arg           
    125                 130                 135                           

agc gcc cag gcc cgg gtg acc gtc gag tgg ctg cgc gtc cgc gac gac        545
Ser Ala Gln Ala Arg Val Thr Val Glu Trp Leu Arg Val Arg Asp Asp           
140                 145                 150                 155           

ggc tcc aac cgc acc tcc ctc atc gac tcc agg ctg gtg tcc gtc cac        593
Gly Ser Asn Arg Thr Ser Leu Ile Asp Ser Arg Leu Val Ser Val His           
                160                 165                 170               

gag agc ggc tgg aag gcc ttc gac gtg acc gag gcc gtg aac ttc tgg        641
Glu Ser Gly Trp Lys Ala Phe Asp Val Thr Glu Ala Val Asn Phe Trp           
            175                 180                 185                   

cag cag ctg agc cgg ccc cgg cag ccg ctg ctg cta cag gtg tcg gtg        689
Gln Gln Leu Ser Arg Pro Arg Gln Pro Leu Leu Leu Gln Val Ser Val           
        190                 195                 200                       

cag agg gag cat ctg ggc ccg ctg gcg tcc ggc gcc cac aag ctg gtc        737
Gln Arg Glu His Leu Gly Pro Leu Ala Ser Gly Ala His Lys Leu Val           
    205                 210                 215                           

cgc ttt gcc tcg cag ggg gcg cca gcc ggg ctt ggg gag ccc cag ctg        785
Arg Phe Ala Ser Gln Gly Ala Pro Ala Gly Leu Gly Glu Pro Gln Leu           
220                 225                 230                 235           

gag ctg cac acc ctg gac ctc agg gac tat gga gct cag ggc gac tgt        833
Glu Leu His Thr Leu Asp Leu Arg Asp Tyr Gly Ala Gln Gly Asp Cys           
                240                 245                 250               

gac cct gaa gca cca atg acc gag ggc acc cgc tgc tgc cgc cag gag        881
Asp Pro Glu Ala Pro Met Thr Glu Gly Thr Arg Cys Cys Arg Gln Glu           
            255                 260                 265                   

atg tac att gac ctg cag ggg atg aag tgg gcc aag aac tgg gtg ctg        929
Met Tyr Ile Asp Leu Gln Gly Met Lys Trp Ala Lys Asn Trp Val Leu           
        270                 275                 280                       

gag ccc ccg ggc ttc ctg gct tac gag tgt gtg ggc acc tgc cag cag        977
Glu Pro Pro Gly Phe Leu Ala Tyr Glu Cys Val Gly Thr Cys Gln Gln           
    285                 290                 295                           

ccc ccg gag gcc ctg gcc ttc aat tgg cca ttt ctg ggg ccg cga cag       1025
Pro Pro Glu Ala Leu Ala Phe Asn Trp Pro Phe Leu Gly Pro Arg Gln           
300                 305                 310                 315           

tgt atc gcc tcg gag act gcc tcg ctg ccc atg atc gtc agc atc aag       1073
Cys Ile Ala Ser Glu Thr Ala Ser Leu Pro Met Ile Val Ser Ile Lys           
                320                 325                 330               

gag gga ggc agg acc agg ccc cag gtg gtc agc ctg ccc aac atg agg       1121
Glu Gly Gly Arg Thr Arg Pro Gln Val Val Ser Leu Pro Asn Met Arg           
            335                 340                 345                   

gtg cag aag tgc agc tgt gcc tcg gat ggg gcg ctc gtg cca agg agg       1169
Val Gln Lys Cys Ser Cys Ala Ser Asp Gly Ala Leu Val Pro Arg Arg           
        350                 355                 360                       

ctc cag cca tag gcgcctggtg tatccattga gccctctaac tgaacgtgtg           1221
Leu Gln Pro                                                               
    365                                                                   

catagaggtg gtcttaatgt aggtcttaac tttatactta gcaagttact ccatcccaat     1281

ttagtgctcc tgtgtgacct tcgccctgtg tccttccatt tcctgtcttt cccgtccatc     1341

acccatccta agcacttacg tgagtaaata atgcagctca gatgctgagc tctagtagga     1401

aatgctggca tgctgattac aagatacagc tgagcaatgc acacattttc agctgggagt     1461

ttctgttctc tggcaaattc ttcactgagt ctggaacaat aataccctat gattagaact     1521

ggggaaacag aactgaattg ctgtgttata tgaggaatta aaaccttcaa atctctattt     1581

cccccaaata ctgacccatt ctggactttt gtaaacatac ctaggcccct gttcccctga     1641

gagggtgcta agaggaagga tgaagggctt caggctgggg gcagtggaca gggaattggg     1701

atacctggat tctggttctg acagggccac aagctaggat ctctaacaaa cgcagaaggc     1761

tttggctcgt catttcctct taaaaaggag gagctgggct tcagctctaa gaacttcatt     1821

gccctgggga tcagacagcc cctacctacc cctgcccact cctctggaga ctgagccttg     1881

cccgtgcata tttaggtcat ttcccacact gtcttagaga acttgtcacc agaaaccaca     1941

tgtatttgca tgttttttgt taatttagct aaagcaattg aatgtagata ctcagaagaa     2001

ataaaaaatg atgtttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2061

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         2102


<210>  190
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Trp Pro Leu Trp Leu Cys Trp Ala Leu Trp Val Leu Pro Leu Ala 
1               5                   10                  15      


Gly Pro Gly Ala Ala Leu Thr Glu Glu Gln Leu Leu Gly Ser Leu Leu 
            20                  25                  30          


Arg Gln Leu Gln Leu Ser Glu Val Pro Val Leu Asp Arg Ala Asp Met 
        35                  40                  45              


Glu Lys Leu Val Ile Pro Ala His Val Arg Ala Gln Tyr Val Val Leu 
    50                  55                  60                  


Leu Arg Arg Ser His Gly Asp Arg Ser Arg Gly Lys Arg Phe Ser Gln 
65                  70                  75                  80  


Ser Phe Arg Glu Val Ala Gly Arg Phe Leu Ala Ser Glu Ala Ser Thr 
                85                  90                  95      


His Leu Leu Val Phe Gly Met Glu Gln Arg Leu Pro Pro Asn Ser Glu 
            100                 105                 110         


Leu Val Gln Ala Val Leu Arg Leu Phe Gln Glu Pro Val Pro Lys Ala 
        115                 120                 125             


Ala Leu His Arg His Gly Arg Leu Ser Pro Arg Ser Ala Gln Ala Arg 
    130                 135                 140                 


Val Thr Val Glu Trp Leu Arg Val Arg Asp Asp Gly Ser Asn Arg Thr 
145                 150                 155                 160 


Ser Leu Ile Asp Ser Arg Leu Val Ser Val His Glu Ser Gly Trp Lys 
                165                 170                 175     


Ala Phe Asp Val Thr Glu Ala Val Asn Phe Trp Gln Gln Leu Ser Arg 
            180                 185                 190         


Pro Arg Gln Pro Leu Leu Leu Gln Val Ser Val Gln Arg Glu His Leu 
        195                 200                 205             


Gly Pro Leu Ala Ser Gly Ala His Lys Leu Val Arg Phe Ala Ser Gln 
    210                 215                 220                 


Gly Ala Pro Ala Gly Leu Gly Glu Pro Gln Leu Glu Leu His Thr Leu 
225                 230                 235                 240 


Asp Leu Arg Asp Tyr Gly Ala Gln Gly Asp Cys Asp Pro Glu Ala Pro 
                245                 250                 255     


Met Thr Glu Gly Thr Arg Cys Cys Arg Gln Glu Met Tyr Ile Asp Leu 
            260                 265                 270         


Gln Gly Met Lys Trp Ala Lys Asn Trp Val Leu Glu Pro Pro Gly Phe 
        275                 280                 285             


Leu Ala Tyr Glu Cys Val Gly Thr Cys Gln Gln Pro Pro Glu Ala Leu 
    290                 295                 300                 


Ala Phe Asn Trp Pro Phe Leu Gly Pro Arg Gln Cys Ile Ala Ser Glu 
305                 310                 315                 320 


Thr Ala Ser Leu Pro Met Ile Val Ser Ile Lys Glu Gly Gly Arg Thr 
                325                 330                 335     


Arg Pro Gln Val Val Ser Leu Pro Asn Met Arg Val Gln Lys Cys Ser 
            340                 345                 350         


Cys Ala Ser Asp Gly Ala Leu Val Pro Arg Arg Leu Gln Pro 
        355                 360                 365     


<210>  191
<211>  1398
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (233)..(1204)

<400>  191
agcggagggg cgccctaacg aacccgggat acggtctgtt cctagtccgc tccggaaatg       60

caactgcgta cgggctggcc gcgtaatcgt gacgacagcg cgccagcgcc ggctagccgg      120

acgccctagg cttccgcgag atcttcggtg ggggtacggg tgttttacgc caggacgctg      180

atgcgtttgg gttctcgtct gcagaccctc tggacctggt cacgattcca ta atg tac      238
                                                          Met Tyr         
                                                          1               

cac aac agt agt cag aag cgg cac tgg acc ttc tcc agc gag gag cag        286
His Asn Ser Ser Gln Lys Arg His Trp Thr Phe Ser Ser Glu Glu Gln           
        5                   10                  15                        

ctg gca aga ctg cgg gct gac gcc aac cgc aaa ttc aga tgc aaa gcc        334
Leu Ala Arg Leu Arg Ala Asp Ala Asn Arg Lys Phe Arg Cys Lys Ala           
    20                  25                  30                            

gtg gcc aac ggg aag gtt ctt ccg aat gat cca gtc ttt ctt gag cct        382
Val Ala Asn Gly Lys Val Leu Pro Asn Asp Pro Val Phe Leu Glu Pro           
35                  40                  45                  50            

cat gaa gaa atg aca ctc tgc aaa tac tat gag aaa agg tta ttg gaa        430
His Glu Glu Met Thr Leu Cys Lys Tyr Tyr Glu Lys Arg Leu Leu Glu           
                55                  60                  65                

ttc tgt tcg gtg ttt aag cca gca atg cca aga tct gtt gtg ggt acg        478
Phe Cys Ser Val Phe Lys Pro Ala Met Pro Arg Ser Val Val Gly Thr           
            70                  75                  80                    

gct tgt atg tat ttc aaa cgt ttt tat ctt aat aac tca gta atg gaa        526
Ala Cys Met Tyr Phe Lys Arg Phe Tyr Leu Asn Asn Ser Val Met Glu           
        85                  90                  95                        

tat cac ccc agg ata ata atg ctc act tgt gca ttt ttg gcc tgc aaa        574
Tyr His Pro Arg Ile Ile Met Leu Thr Cys Ala Phe Leu Ala Cys Lys           
    100                 105                 110                           

gta gat gaa ttc aat gta tct agt cct cag ttt gtt gga aac ctc cgg        622
Val Asp Glu Phe Asn Val Ser Ser Pro Gln Phe Val Gly Asn Leu Arg           
115                 120                 125                 130           

gag agt cct ctt gga cag gag aag gca ctt gaa cag ata ctg gaa tat        670
Glu Ser Pro Leu Gly Gln Glu Lys Ala Leu Glu Gln Ile Leu Glu Tyr           
                135                 140                 145               

gaa cta ctt ctt ata cag caa ctt aat ttc cac ctt att gtc cac aat        718
Glu Leu Leu Leu Ile Gln Gln Leu Asn Phe His Leu Ile Val His Asn           
            150                 155                 160                   

cct tac aga cca ttt gag ggc ttc ctc atc gac tta aag acc cgc tat        766
Pro Tyr Arg Pro Phe Glu Gly Phe Leu Ile Asp Leu Lys Thr Arg Tyr           
        165                 170                 175                       

ccc ata ttg gag aat cca gag att ttg agg aaa aca gct gat gac ttt        814
Pro Ile Leu Glu Asn Pro Glu Ile Leu Arg Lys Thr Ala Asp Asp Phe           
    180                 185                 190                           

ctt aat aga att gca ttg acg gat gct tac ctt tta tac aca cct tcc        862
Leu Asn Arg Ile Ala Leu Thr Asp Ala Tyr Leu Leu Tyr Thr Pro Ser           
195                 200                 205                 210           

caa att gcc ctg act gcc att tta tct agt gcc tcc agg gct gga att        910
Gln Ile Ala Leu Thr Ala Ile Leu Ser Ser Ala Ser Arg Ala Gly Ile           
                215                 220                 225               

act atg gaa agt tat tta tca gag agt ctg atg ctg aaa gag aac aga        958
Thr Met Glu Ser Tyr Leu Ser Glu Ser Leu Met Leu Lys Glu Asn Arg           
            230                 235                 240                   

act tgc ctg tca cag tta cta gat ata atg aaa agc atg aga aac tta       1006
Thr Cys Leu Ser Gln Leu Leu Asp Ile Met Lys Ser Met Arg Asn Leu           
        245                 250                 255                       

gta aag aag tat gaa cca ccc aga tct gaa gaa gtt gct gtt ctg aaa       1054
Val Lys Lys Tyr Glu Pro Pro Arg Ser Glu Glu Val Ala Val Leu Lys           
    260                 265                 270                           

cag aag ttg gag cga tgt cat tct gct gag ctt gca ctt aac gta atc       1102
Gln Lys Leu Glu Arg Cys His Ser Ala Glu Leu Ala Leu Asn Val Ile           
275                 280                 285                 290           

acg aag aag agg aaa ggc tat gaa gat gat gat tac gtc tca aag aaa       1150
Thr Lys Lys Arg Lys Gly Tyr Glu Asp Asp Asp Tyr Val Ser Lys Lys           
                295                 300                 305               

tcc aaa cat gag gag gaa gaa tgg act gat gac gac ctg gta gaa tct       1198
Ser Lys His Glu Glu Glu Glu Trp Thr Asp Asp Asp Leu Val Glu Ser           
            310                 315                 320                   

ctc taa ccatttgaag ttgatttctc aatgctaact aatcaagaga agtaggaagc        1254
Leu                                                                       
                                                                          

atatcaaacg tttaacttta tttaaaaagt ataatgtgaa aacataaaat atattaaaac     1314

ttttctattg ttttctttcc ctttcacagt aactttatgt aaaataaacc atcttcaaaa     1374

gagctagaat aaaaaaaaaa aaaa                                            1398


<210>  192
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Tyr His Asn Ser Ser Gln Lys Arg His Trp Thr Phe Ser Ser Glu 
1               5                   10                  15      


Glu Gln Leu Ala Arg Leu Arg Ala Asp Ala Asn Arg Lys Phe Arg Cys 
            20                  25                  30          


Lys Ala Val Ala Asn Gly Lys Val Leu Pro Asn Asp Pro Val Phe Leu 
        35                  40                  45              


Glu Pro His Glu Glu Met Thr Leu Cys Lys Tyr Tyr Glu Lys Arg Leu 
    50                  55                  60                  


Leu Glu Phe Cys Ser Val Phe Lys Pro Ala Met Pro Arg Ser Val Val 
65                  70                  75                  80  


Gly Thr Ala Cys Met Tyr Phe Lys Arg Phe Tyr Leu Asn Asn Ser Val 
                85                  90                  95      


Met Glu Tyr His Pro Arg Ile Ile Met Leu Thr Cys Ala Phe Leu Ala 
            100                 105                 110         


Cys Lys Val Asp Glu Phe Asn Val Ser Ser Pro Gln Phe Val Gly Asn 
        115                 120                 125             


Leu Arg Glu Ser Pro Leu Gly Gln Glu Lys Ala Leu Glu Gln Ile Leu 
    130                 135                 140                 


Glu Tyr Glu Leu Leu Leu Ile Gln Gln Leu Asn Phe His Leu Ile Val 
145                 150                 155                 160 


His Asn Pro Tyr Arg Pro Phe Glu Gly Phe Leu Ile Asp Leu Lys Thr 
                165                 170                 175     


Arg Tyr Pro Ile Leu Glu Asn Pro Glu Ile Leu Arg Lys Thr Ala Asp 
            180                 185                 190         


Asp Phe Leu Asn Arg Ile Ala Leu Thr Asp Ala Tyr Leu Leu Tyr Thr 
        195                 200                 205             


Pro Ser Gln Ile Ala Leu Thr Ala Ile Leu Ser Ser Ala Ser Arg Ala 
    210                 215                 220                 


Gly Ile Thr Met Glu Ser Tyr Leu Ser Glu Ser Leu Met Leu Lys Glu 
225                 230                 235                 240 


Asn Arg Thr Cys Leu Ser Gln Leu Leu Asp Ile Met Lys Ser Met Arg 
                245                 250                 255     


Asn Leu Val Lys Lys Tyr Glu Pro Pro Arg Ser Glu Glu Val Ala Val 
            260                 265                 270         


Leu Lys Gln Lys Leu Glu Arg Cys His Ser Ala Glu Leu Ala Leu Asn 
        275                 280                 285             


Val Ile Thr Lys Lys Arg Lys Gly Tyr Glu Asp Asp Asp Tyr Val Ser 
    290                 295                 300                 


Lys Lys Ser Lys His Glu Glu Glu Glu Trp Thr Asp Asp Asp Leu Val 
305                 310                 315                 320 


Glu Ser Leu 
            


<210>  193
<211>  1511
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1281)

<400>  193
atg ggg act gag act gtg cct cag cct tcc tgg gaa gcc atc aac cac         48
Met Gly Thr Glu Thr Val Pro Gln Pro Ser Trp Glu Ala Ile Asn His           
1               5                   10                  15                

atg tgg cat gac cac tac tac aga gga cat gac tcc tac ctg gcc atc         96
Met Trp His Asp His Tyr Tyr Arg Gly His Asp Ser Tyr Leu Ala Ile           
            20                  25                  30                    

ctg ctc ccc aac ccc ttc tac ccg gat ccc tgg gct gtg ccg aga tcc        144
Leu Leu Pro Asn Pro Phe Tyr Pro Asp Pro Trp Ala Val Pro Arg Ser           
        35                  40                  45                        

tgg aca gtg cct gtg ggt aca gag gac tgt ggc cac acc aaa gag ata        192
Trp Thr Val Pro Val Gly Thr Glu Asp Cys Gly His Thr Lys Glu Ile           
    50                  55                  60                            

tgc aac ggg cag ctc aag cta gag ccc tgg gcc ggt gtc tcc ctg gca        240
Cys Asn Gly Gln Leu Lys Leu Glu Pro Trp Ala Gly Val Ser Leu Ala           
65                  70                  75                  80            

tca gtg ccc ctg ccg gta atg gag ggc ctc gtg gtg ggc tgt gtc ctc        288
Ser Val Pro Leu Pro Val Met Glu Gly Leu Val Val Gly Cys Val Leu           
                85                  90                  95                

acc atc tgt gct gtg ctg ggc ctg ctg tgc tgg agg cgg gtg aag ggg        336
Thr Ile Cys Ala Val Leu Gly Leu Leu Cys Trp Arg Arg Val Lys Gly           
            100                 105                 110                   

cag agg gca ggg aag aat cca ttt tcc caa gag ctg aca gct tac aac        384
Gln Arg Ala Gly Lys Asn Pro Phe Ser Gln Glu Leu Thr Ala Tyr Asn           
        115                 120                 125                       

ctg cgc ttc agg cag agc tat gag gcc aag agt gct cac gca cac cag        432
Leu Arg Phe Arg Gln Ser Tyr Glu Ala Lys Ser Ala His Ala His Gln           
    130                 135                 140                           

gct ttc ttt ttg caa ttc gag gag ctg aag gag gtg ggc aag gag cag        480
Ala Phe Phe Leu Gln Phe Glu Glu Leu Lys Glu Val Gly Lys Glu Gln           
145                 150                 155                 160           

ccc aga ctg gag gct gag tac gct gcc aac acc acc aag aac cat tac        528
Pro Arg Leu Glu Ala Glu Tyr Ala Ala Asn Thr Thr Lys Asn His Tyr           
                165                 170                 175               

cca cat gtg ctt ccc tac gac cac tcc agg gtc agg ctg acc cag ctg        576
Pro His Val Leu Pro Tyr Asp His Ser Arg Val Arg Leu Thr Gln Leu           
            180                 185                 190                   

gag gga gag cct cat tct gac tac atc aat gcc aac ttc atc cca gtg        624
Glu Gly Glu Pro His Ser Asp Tyr Ile Asn Ala Asn Phe Ile Pro Val           
        195                 200                 205                       

ctg tgt gag cat tac tgg ctg acc gac tct acc ccg gtc acc cat gat        672
Leu Cys Glu His Tyr Trp Leu Thr Asp Ser Thr Pro Val Thr His Asp           
    210                 215                 220                           

cac atc acc atc cac ctc cta gcc gag gag gct gac gat gag tgg acc        720
His Ile Thr Ile His Leu Leu Ala Glu Glu Ala Asp Asp Glu Trp Thr           
225                 230                 235                 240           

aag cgg gaa ttc cag ctg cag cac atg cgt gcc cca agg atg agg ggt        768
Lys Arg Glu Phe Gln Leu Gln His Met Arg Ala Pro Arg Met Arg Gly           
                245                 250                 255               

gtg ggc atg ggc cag acg ggc acc ttc gtg gcc ctg ttg agg ctg ctg        816
Val Gly Met Gly Gln Thr Gly Thr Phe Val Ala Leu Leu Arg Leu Leu           
            260                 265                 270                   

cag cag ctg gag gag gag cag atg gta gat gtg ttc cat gct gtg ttt        864
Gln Gln Leu Glu Glu Glu Gln Met Val Asp Val Phe His Ala Val Phe           
        275                 280                 285                       

gca ttc tgg atg cac ggg ccc ctc atg atc cag acc ctg ggc tac aag        912
Ala Phe Trp Met His Gly Pro Leu Met Ile Gln Thr Leu Gly Tyr Lys           
    290                 295                 300                           

agg gac cag gaa aga gag ctc atg ggg cat aca gaa gac cct ggg gag        960
Arg Asp Gln Glu Arg Glu Leu Met Gly His Thr Glu Asp Pro Gly Glu           
305                 310                 315                 320           

agg gtt tca aac aca aca cca tcc tat ctg ggc tgt gct ccc tat tct       1008
Arg Val Ser Asn Thr Thr Pro Ser Tyr Leu Gly Cys Ala Pro Tyr Ser           
                325                 330                 335               

gtg aaa ggg gag gtg gga cag gac cct gtc agc ttt gac acc ata gag       1056
Val Lys Gly Glu Val Gly Gln Asp Pro Val Ser Phe Asp Thr Ile Glu           
            340                 345                 350                   

cgg tgg agg gaa ggt ttc tca gtg gct ccc tct ccc ctc cta ccc gat       1104
Arg Trp Arg Glu Gly Phe Ser Val Ala Pro Ser Pro Leu Leu Pro Asp           
        355                 360                 365                       

ccc tgc ctt gct ggt cag ggc ctg gaa aat ctc cct gca ggc ccc cct       1152
Pro Cys Leu Ala Gly Gln Gly Leu Glu Asn Leu Pro Ala Gly Pro Pro           
    370                 375                 380                           

cgc tcc tcg ctc ctc gct cct cgc tcc tcg ctg agc agc ctg atg ccc       1200
Arg Ser Ser Leu Leu Ala Pro Arg Ser Ser Leu Ser Ser Leu Met Pro           
385                 390                 395                 400           

ttc ccc ctg gca gag cca gta cgt ctt cct gca cag ctg cct act gaa       1248
Phe Pro Leu Ala Glu Pro Val Arg Leu Pro Ala Gln Leu Pro Thr Glu           
                405                 410                 415               

caa gat tct gga agg gcc ctt caa cat ctc tga gtcttggccc atctctgtga     1301
Gln Asp Ser Gly Arg Ala Leu Gln His Leu                                   
            420                 425                                       

tgaacttcgc acaggcgtgt gccaagaggg cagccaatgc caacgctggc ttcttgaagg     1361

agtacgagct cttgctgcag gccatcaagg acgaggctgg ctcttacgca cccctgcctg     1421

gctatgagca ggacagcccc atctcctggt gggccctctg gctgtgatca tatggtgctg     1481

actggcctcg cagggccaga ggagctctgg                                      1511


<210>  194
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Gly Thr Glu Thr Val Pro Gln Pro Ser Trp Glu Ala Ile Asn His 
1               5                   10                  15      


Met Trp His Asp His Tyr Tyr Arg Gly His Asp Ser Tyr Leu Ala Ile 
            20                  25                  30          


Leu Leu Pro Asn Pro Phe Tyr Pro Asp Pro Trp Ala Val Pro Arg Ser 
        35                  40                  45              


Trp Thr Val Pro Val Gly Thr Glu Asp Cys Gly His Thr Lys Glu Ile 
    50                  55                  60                  


Cys Asn Gly Gln Leu Lys Leu Glu Pro Trp Ala Gly Val Ser Leu Ala 
65                  70                  75                  80  


Ser Val Pro Leu Pro Val Met Glu Gly Leu Val Val Gly Cys Val Leu 
                85                  90                  95      


Thr Ile Cys Ala Val Leu Gly Leu Leu Cys Trp Arg Arg Val Lys Gly 
            100                 105                 110         


Gln Arg Ala Gly Lys Asn Pro Phe Ser Gln Glu Leu Thr Ala Tyr Asn 
        115                 120                 125             


Leu Arg Phe Arg Gln Ser Tyr Glu Ala Lys Ser Ala His Ala His Gln 
    130                 135                 140                 


Ala Phe Phe Leu Gln Phe Glu Glu Leu Lys Glu Val Gly Lys Glu Gln 
145                 150                 155                 160 


Pro Arg Leu Glu Ala Glu Tyr Ala Ala Asn Thr Thr Lys Asn His Tyr 
                165                 170                 175     


Pro His Val Leu Pro Tyr Asp His Ser Arg Val Arg Leu Thr Gln Leu 
            180                 185                 190         


Glu Gly Glu Pro His Ser Asp Tyr Ile Asn Ala Asn Phe Ile Pro Val 
        195                 200                 205             


Leu Cys Glu His Tyr Trp Leu Thr Asp Ser Thr Pro Val Thr His Asp 
    210                 215                 220                 


His Ile Thr Ile His Leu Leu Ala Glu Glu Ala Asp Asp Glu Trp Thr 
225                 230                 235                 240 


Lys Arg Glu Phe Gln Leu Gln His Met Arg Ala Pro Arg Met Arg Gly 
                245                 250                 255     


Val Gly Met Gly Gln Thr Gly Thr Phe Val Ala Leu Leu Arg Leu Leu 
            260                 265                 270         


Gln Gln Leu Glu Glu Glu Gln Met Val Asp Val Phe His Ala Val Phe 
        275                 280                 285             


Ala Phe Trp Met His Gly Pro Leu Met Ile Gln Thr Leu Gly Tyr Lys 
    290                 295                 300                 


Arg Asp Gln Glu Arg Glu Leu Met Gly His Thr Glu Asp Pro Gly Glu 
305                 310                 315                 320 


Arg Val Ser Asn Thr Thr Pro Ser Tyr Leu Gly Cys Ala Pro Tyr Ser 
                325                 330                 335     


Val Lys Gly Glu Val Gly Gln Asp Pro Val Ser Phe Asp Thr Ile Glu 
            340                 345                 350         


Arg Trp Arg Glu Gly Phe Ser Val Ala Pro Ser Pro Leu Leu Pro Asp 
        355                 360                 365             


Pro Cys Leu Ala Gly Gln Gly Leu Glu Asn Leu Pro Ala Gly Pro Pro 
    370                 375                 380                 


Arg Ser Ser Leu Leu Ala Pro Arg Ser Ser Leu Ser Ser Leu Met Pro 
385                 390                 395                 400 


Phe Pro Leu Ala Glu Pro Val Arg Leu Pro Ala Gln Leu Pro Thr Glu 
                405                 410                 415     


Gln Asp Ser Gly Arg Ala Leu Gln His Leu 
            420                 425     


<210>  195
<211>  1776
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (74)..(1459)

<400>  195
gctgtcatgg cggcaggacg gcgaacttgc agtatctcca cgacccgccc ctacaggtgc       60

cagtgcctcc aga atg tgg cag ctc aca agc ctc ctg ctg ttc gtg gcc         109
               Met Trp Gln Leu Thr Ser Leu Leu Leu Phe Val Ala            
               1               5                   10                     

acc tgg gga att tcc ggc aca cca gct cct ctt gac tca gtg ttc tcc        157
Thr Trp Gly Ile Ser Gly Thr Pro Ala Pro Leu Asp Ser Val Phe Ser           
        15                  20                  25                        

agc agc gag cgt gcc cac cag gtg ctg cgg atc cgc aaa cgt gcc aac        205
Ser Ser Glu Arg Ala His Gln Val Leu Arg Ile Arg Lys Arg Ala Asn           
    30                  35                  40                            

tcc ttc ctg gag gag ctc cgt cac agc agc ctg gag cgg gag tgc ata        253
Ser Phe Leu Glu Glu Leu Arg His Ser Ser Leu Glu Arg Glu Cys Ile           
45                  50                  55                  60            

gag gag atc tgt gac ttc gag gag gcc aag gaa att ttc caa aat gtg        301
Glu Glu Ile Cys Asp Phe Glu Glu Ala Lys Glu Ile Phe Gln Asn Val           
                65                  70                  75                

gat gac aca ctg gcc ttc tgg tcc aag cac gtc gac ggt gac cag tgc        349
Asp Asp Thr Leu Ala Phe Trp Ser Lys His Val Asp Gly Asp Gln Cys           
            80                  85                  90                    

ttg gtc ttg ccc ttg gag cac ccg tgc gcc agc ctg tgc tgc ggg cac        397
Leu Val Leu Pro Leu Glu His Pro Cys Ala Ser Leu Cys Cys Gly His           
        95                  100                 105                       

ggc acg tgc atc gac ggc atc ggc agc ttc agc tgc gac tgc cgc agc        445
Gly Thr Cys Ile Asp Gly Ile Gly Ser Phe Ser Cys Asp Cys Arg Ser           
    110                 115                 120                           

ggc tgg gag ggc cgc ttc tgc cag cgc gag gtg agc ttc ctc aat tgc        493
Gly Trp Glu Gly Arg Phe Cys Gln Arg Glu Val Ser Phe Leu Asn Cys           
125                 130                 135                 140           

tcg ctg gac aac ggc ggc tgc acg cat tac tgc cta gag gag gtg ggc        541
Ser Leu Asp Asn Gly Gly Cys Thr His Tyr Cys Leu Glu Glu Val Gly           
                145                 150                 155               

tgg cgg cgc tgt agc tgt gcg cct ggc tac aag ctg ggg gac gac ctc        589
Trp Arg Arg Cys Ser Cys Ala Pro Gly Tyr Lys Leu Gly Asp Asp Leu           
            160                 165                 170                   

ctg cag tgt cac ccc gca gtg aag ttc cct tgt ggg agg ccc tgg aag        637
Leu Gln Cys His Pro Ala Val Lys Phe Pro Cys Gly Arg Pro Trp Lys           
        175                 180                 185                       

cgg atg gag aag aag cgc agt cac ctg aaa cga gac aca gaa gac caa        685
Arg Met Glu Lys Lys Arg Ser His Leu Lys Arg Asp Thr Glu Asp Gln           
    190                 195                 200                           

gaa gac caa gta gat ccg cgg ctc att gat ggg aag atg acc agg cgg        733
Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys Met Thr Arg Arg           
205                 210                 215                 220           

gga gac agc ccc tgg cag gtg gtc ctg ctg gac tca aag aag aag ctg        781
Gly Asp Ser Pro Trp Gln Val Val Leu Leu Asp Ser Lys Lys Lys Leu           
                225                 230                 235               

gcc tgc ggg gca gtg ctc atc cac ccc tcc tgg gtg ctg aca gcg gcc        829
Ala Cys Gly Ala Val Leu Ile His Pro Ser Trp Val Leu Thr Ala Ala           
            240                 245                 250                   

cac tgc atg gat gag tcc aag aag ctc ctt gtc agg ctt gga gag tat        877
His Cys Met Asp Glu Ser Lys Lys Leu Leu Val Arg Leu Gly Glu Tyr           
        255                 260                 265                       

gac ctg cgg cgc tgg gag aag tgg gag ctg gac ctg gac atc aag gag        925
Asp Leu Arg Arg Trp Glu Lys Trp Glu Leu Asp Leu Asp Ile Lys Glu           
    270                 275                 280                           

gtc ttc gtc cac ccc aac tac agc aag agc acc acc gac aat gac atc        973
Val Phe Val His Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn Asp Ile           
285                 290                 295                 300           

gca ctg ctg cac ctg gcc cag ccc gcc acc ctc tcg cag acc ata gtg       1021
Ala Leu Leu His Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr Ile Val           
                305                 310                 315               

ccc atc tgc ctc ccg gac agc ggc ctt gca gag cgc gag ctc aat cag       1069
Pro Ile Cys Leu Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu Asn Gln           
            320                 325                 330                   

gcc ggc cag gag acc ctc gtg acg ggc tgg ggc tac cac agc agc cga       1117
Ala Gly Gln Glu Thr Leu Val Thr Gly Trp Gly Tyr His Ser Ser Arg           
        335                 340                 345                       

gag aag gag gcc aag aga aac cgc acc ttc gtc ctc aac ttc atc aag       1165
Glu Lys Glu Ala Lys Arg Asn Arg Thr Phe Val Leu Asn Phe Ile Lys           
    350                 355                 360                           

att ccc gtg gtc ccg cac aat gag tgc agc gag gtc atg agc aac atg       1213
Ile Pro Val Val Pro His Asn Glu Cys Ser Glu Val Met Ser Asn Met           
365                 370                 375                 380           

gtg tct gag aac atg ctg tgt gcg ggc atc ctc ggg gac cgg cag gat       1261
Val Ser Glu Asn Met Leu Cys Ala Gly Ile Leu Gly Asp Arg Gln Asp           
                385                 390                 395               

gcc tgc gag ggc gac agt ggg ggg ccc atg gtc gcc tcc ttc cac ggc       1309
Ala Cys Glu Gly Asp Ser Gly Gly Pro Met Val Ala Ser Phe His Gly           
            400                 405                 410                   

acc tgg ttc ctg gtg ggc ctg gtg agc tgg ggt gag ggc tgt ggg ctc       1357
Thr Trp Phe Leu Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly Leu           
        415                 420                 425                       

ctt cac aac tac ggc gtt tac acc aaa gtc agc cgc tac ctc gac tgg       1405
Leu His Asn Tyr Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp           
    430                 435                 440                           

atc cat ggg cac atc aga gac aag gaa gcc ccc cag aag agc tgg gca       1453
Ile His Gly His Ile Arg Asp Lys Glu Ala Pro Gln Lys Ser Trp Ala           
445                 450                 455                 460           

cct tag cgaccctccc tgcagggctg ggcttttgca tggcaatgga tgggacatta        1509
Pro                                                                       
                                                                          

aagggacatg taacaagcac accggcctgc tgttctgtcc ttccatccct cttttgggct     1569

cttctggagg gaagtaacat ttactgagca cctgttgtat gtcacatgcc ttatgaatag     1629

aatcttaact cctagagcaa ctctgtgggg tggggaggag cagatccaag ttttgcgggg     1689

tctaaagctg tgtgtgttga gggggatact ctgtttatga aaaagaataa aaaacacaac     1749

cacgaaaaaa aaaaaaaaaa aaaaaaa                                         1776


<210>  196
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Trp Gln Leu Thr Ser Leu Leu Leu Phe Val Ala Thr Trp Gly Ile 
1               5                   10                  15      


Ser Gly Thr Pro Ala Pro Leu Asp Ser Val Phe Ser Ser Ser Glu Arg 
            20                  25                  30          


Ala His Gln Val Leu Arg Ile Arg Lys Arg Ala Asn Ser Phe Leu Glu 
        35                  40                  45              


Glu Leu Arg His Ser Ser Leu Glu Arg Glu Cys Ile Glu Glu Ile Cys 
    50                  55                  60                  


Asp Phe Glu Glu Ala Lys Glu Ile Phe Gln Asn Val Asp Asp Thr Leu 
65                  70                  75                  80  


Ala Phe Trp Ser Lys His Val Asp Gly Asp Gln Cys Leu Val Leu Pro 
                85                  90                  95      


Leu Glu His Pro Cys Ala Ser Leu Cys Cys Gly His Gly Thr Cys Ile 
            100                 105                 110         


Asp Gly Ile Gly Ser Phe Ser Cys Asp Cys Arg Ser Gly Trp Glu Gly 
        115                 120                 125             


Arg Phe Cys Gln Arg Glu Val Ser Phe Leu Asn Cys Ser Leu Asp Asn 
    130                 135                 140                 


Gly Gly Cys Thr His Tyr Cys Leu Glu Glu Val Gly Trp Arg Arg Cys 
145                 150                 155                 160 


Ser Cys Ala Pro Gly Tyr Lys Leu Gly Asp Asp Leu Leu Gln Cys His 
                165                 170                 175     


Pro Ala Val Lys Phe Pro Cys Gly Arg Pro Trp Lys Arg Met Glu Lys 
            180                 185                 190         


Lys Arg Ser His Leu Lys Arg Asp Thr Glu Asp Gln Glu Asp Gln Val 
        195                 200                 205             


Asp Pro Arg Leu Ile Asp Gly Lys Met Thr Arg Arg Gly Asp Ser Pro 
    210                 215                 220                 


Trp Gln Val Val Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly Ala 
225                 230                 235                 240 


Val Leu Ile His Pro Ser Trp Val Leu Thr Ala Ala His Cys Met Asp 
                245                 250                 255     


Glu Ser Lys Lys Leu Leu Val Arg Leu Gly Glu Tyr Asp Leu Arg Arg 
            260                 265                 270         


Trp Glu Lys Trp Glu Leu Asp Leu Asp Ile Lys Glu Val Phe Val His 
        275                 280                 285             


Pro Asn Tyr Ser Lys Ser Thr Thr Asp Asn Asp Ile Ala Leu Leu His 
    290                 295                 300                 


Leu Ala Gln Pro Ala Thr Leu Ser Gln Thr Ile Val Pro Ile Cys Leu 
305                 310                 315                 320 


Pro Asp Ser Gly Leu Ala Glu Arg Glu Leu Asn Gln Ala Gly Gln Glu 
                325                 330                 335     


Thr Leu Val Thr Gly Trp Gly Tyr His Ser Ser Arg Glu Lys Glu Ala 
            340                 345                 350         


Lys Arg Asn Arg Thr Phe Val Leu Asn Phe Ile Lys Ile Pro Val Val 
        355                 360                 365             


Pro His Asn Glu Cys Ser Glu Val Met Ser Asn Met Val Ser Glu Asn 
    370                 375                 380                 


Met Leu Cys Ala Gly Ile Leu Gly Asp Arg Gln Asp Ala Cys Glu Gly 
385                 390                 395                 400 


Asp Ser Gly Gly Pro Met Val Ala Ser Phe His Gly Thr Trp Phe Leu 
                405                 410                 415     


Val Gly Leu Val Ser Trp Gly Glu Gly Cys Gly Leu Leu His Asn Tyr 
            420                 425                 430         


Gly Val Tyr Thr Lys Val Ser Arg Tyr Leu Asp Trp Ile His Gly His 
        435                 440                 445             


Ile Arg Asp Lys Glu Ala Pro Gln Lys Ser Trp Ala Pro 
    450                 455                 460     


<210>  197
<211>  3918
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (319)..(1842)

<400>  197
ctctcccttc tccactctct ccccctgtct cctttcttct tcttctttca ccctccgtct       60

ctcacacccc ctccattccc ctgtctcctt tctgacactg cactgcagct gctcctcagc      120

cctgccccct ccccagtgag aacaaaccag caacattgct ttttttccta aagagattta      180

tattgatccg attaaaaaaa aaaaacctta agaaacccca aacgcaaaaa aaaaaaaaaa      240

aaaaaaagaa aaaagaaaag aaaaagccaa aacaaaaggg agaaccttct cccggtagca      300

gcggcaggaa ctgcaaac atg atg gcg gca gct ccc atc cag cag aac ggg        351
                    Met Met Ala Ala Ala Pro Ile Gln Gln Asn Gly           
                    1               5                   10                

acc cac act ggg gtt ccc ata gac ctg gac ccg ccg gac tcg cgg aaa        399
Thr His Thr Gly Val Pro Ile Asp Leu Asp Pro Pro Asp Ser Arg Lys           
            15                  20                  25                    

agg ccg ctg gaa gcc ccc cct gaa gcc ggc agc acc aag agg acc aat        447
Arg Pro Leu Glu Ala Pro Pro Glu Ala Gly Ser Thr Lys Arg Thr Asn           
        30                  35                  40                        

acg ggc gaa gac ggc cag tat ttt cta aag gtt ctc ata cct agt tat        495
Thr Gly Glu Asp Gly Gln Tyr Phe Leu Lys Val Leu Ile Pro Ser Tyr           
    45                  50                  55                            

gct gct gga tct ata att ggg aag gga gga cag aca att gtt cag ttg        543
Ala Ala Gly Ser Ile Ile Gly Lys Gly Gly Gln Thr Ile Val Gln Leu           
60                  65                  70                  75            

caa aaa gaa act gga gcc acc atc aag ctg tct aag tcc aaa gat ttt        591
Gln Lys Glu Thr Gly Ala Thr Ile Lys Leu Ser Lys Ser Lys Asp Phe           
                80                  85                  90                

tac cca ggt act act gag cga gtg tgc ttg atc cag gga acg gtt gaa        639
Tyr Pro Gly Thr Thr Glu Arg Val Cys Leu Ile Gln Gly Thr Val Glu           
            95                  100                 105                   

gca ctg aat gca gtt cat gga ttc att gca gaa aaa att cga gaa atg        687
Ala Leu Asn Ala Val His Gly Phe Ile Ala Glu Lys Ile Arg Glu Met           
        110                 115                 120                       

ccc caa aat gtg gcc aag aca gaa cca gtc agc att cta caa ccc cag        735
Pro Gln Asn Val Ala Lys Thr Glu Pro Val Ser Ile Leu Gln Pro Gln           
    125                 130                 135                           

acc acc gtt aat cca gat cgc atc aaa caa aca ttg cca tct tcc cca        783
Thr Thr Val Asn Pro Asp Arg Ile Lys Gln Thr Leu Pro Ser Ser Pro           
140                 145                 150                 155           

act acc acc aag tcc tct cca tct gat ccc atg acc acc tcc aga gct        831
Thr Thr Thr Lys Ser Ser Pro Ser Asp Pro Met Thr Thr Ser Arg Ala           
                160                 165                 170               

aat cag gta aag att ata gtt ccc aac agc aca gca ggt ctg ata ata        879
Asn Gln Val Lys Ile Ile Val Pro Asn Ser Thr Ala Gly Leu Ile Ile           
            175                 180                 185                   

ggg aag gga ggt gct act gtg aag gct gta atg gag cag tca ggg gct        927
Gly Lys Gly Gly Ala Thr Val Lys Ala Val Met Glu Gln Ser Gly Ala           
        190                 195                 200                       

tgg gtg cag ctt tcc cag aaa cct gat ggg atc aac ttg caa gag agg        975
Trp Val Gln Leu Ser Gln Lys Pro Asp Gly Ile Asn Leu Gln Glu Arg           
    205                 210                 215                           

gtt gtc act gtg agt gga gaa cct gaa caa aac cga aaa gct gtt gaa       1023
Val Val Thr Val Ser Gly Glu Pro Glu Gln Asn Arg Lys Ala Val Glu           
220                 225                 230                 235           

ctt atc atc cag aag ata caa gag gat cca caa agt ggc agc tgt ctc       1071
Leu Ile Ile Gln Lys Ile Gln Glu Asp Pro Gln Ser Gly Ser Cys Leu           
                240                 245                 250               

aat atc agt tat gcc aat gtg aca ggt cca gtg gca aat tcc aat cca       1119
Asn Ile Ser Tyr Ala Asn Val Thr Gly Pro Val Ala Asn Ser Asn Pro           
            255                 260                 265                   

acc gga tct cct tat gca aac act gct gaa gtg tta cca act gct gca       1167
Thr Gly Ser Pro Tyr Ala Asn Thr Ala Glu Val Leu Pro Thr Ala Ala           
        270                 275                 280                       

gca gct gca ggg cta tta gga cat gct aac ctt gct ggc gtt gca gcc       1215
Ala Ala Ala Gly Leu Leu Gly His Ala Asn Leu Ala Gly Val Ala Ala           
    285                 290                 295                           

ttt cca gca gtt tta tct ggc ttc aca ggc aat gac ctg gtg gcc atc       1263
Phe Pro Ala Val Leu Ser Gly Phe Thr Gly Asn Asp Leu Val Ala Ile           
300                 305                 310                 315           

acc tct gca ctt aat aca tta gcc agc tat gga tat aat ctc aac act       1311
Thr Ser Ala Leu Asn Thr Leu Ala Ser Tyr Gly Tyr Asn Leu Asn Thr           
                320                 325                 330               

tta ggt tta ggt ctc agt caa gca gca gca aca ggg gct ttg gct gca       1359
Leu Gly Leu Gly Leu Ser Gln Ala Ala Ala Thr Gly Ala Leu Ala Ala           
            335                 340                 345                   

gca gct gcc agt gcc aac cca gca gca gca gca gcc aat tta ttg gcc       1407
Ala Ala Ala Ser Ala Asn Pro Ala Ala Ala Ala Ala Asn Leu Leu Ala           
        350                 355                 360                       

acc tat gcc agt gaa gcc tca gcc agt ggc agc aca gct ggt ggt acg       1455
Thr Tyr Ala Ser Glu Ala Ser Ala Ser Gly Ser Thr Ala Gly Gly Thr           
    365                 370                 375                           

gcg ggg aca ttt gca tta ggt agc ctg gct gct gct act gct gca acc       1503
Ala Gly Thr Phe Ala Leu Gly Ser Leu Ala Ala Ala Thr Ala Ala Thr           
380                 385                 390                 395           

aat gga tat ttt gga gct gct tct ccc cta gct gcc agt gcc att cta       1551
Asn Gly Tyr Phe Gly Ala Ala Ser Pro Leu Ala Ala Ser Ala Ile Leu           
                400                 405                 410               

gga aca gaa aag tcc aca gat gga tcc aag gat gta gtt gaa ata gca       1599
Gly Thr Glu Lys Ser Thr Asp Gly Ser Lys Asp Val Val Glu Ile Ala           
            415                 420                 425                   

gtg cca gaa aac tta gtt ggt gca ata ctt ggc aaa gga ggg aaa aca       1647
Val Pro Glu Asn Leu Val Gly Ala Ile Leu Gly Lys Gly Gly Lys Thr           
        430                 435                 440                       

tta gtg gaa tac cag gag ttg act ggt gca agg ata cag atc tcc aaa       1695
Leu Val Glu Tyr Gln Glu Leu Thr Gly Ala Arg Ile Gln Ile Ser Lys           
    445                 450                 455                           

aaa gga gaa ttc gta cct ggc aca agg aat cgg aag gta acc att act       1743
Lys Gly Glu Phe Val Pro Gly Thr Arg Asn Arg Lys Val Thr Ile Thr           
460                 465                 470                 475           

gga aca cca gct gca aca cag gct gct caa tat tta att aca caa agg       1791
Gly Thr Pro Ala Ala Thr Gln Ala Ala Gln Tyr Leu Ile Thr Gln Arg           
                480                 485                 490               

atc aca tat gag caa gga gtt cgg gct gcc aat cct cag aaa gtg ggt       1839
Ile Thr Tyr Glu Gln Gly Val Arg Ala Ala Asn Pro Gln Lys Val Gly           
            495                 500                 505                   

tga gtgccccagt tacacatcag attgttttaa cccctccttt accccatttt            1892

caagaaggat gtactgtact ttgcagaagt gaagtttttc tgttattaat atataattat     1952

gcaaatgaat gcgactatgt tgacaatgtg tatatgtaaa taatatgtgt tttaccagat     2012

gtttcataga aagaattttt tcttgatctg ttttgttctc tatactttgc ttgtgtatat     2072

ttgtcagagg tgtttctagt gtaagattta agcctgccat tttaccagca ttattgtagt     2132

ttaatgattg aatgtagaca gggatatgcg tatagttttc agtattagtt ctagataaca     2192

ctaaattaac tactgttagg ttgagtatgg tggggtcagt gacctaaaat ggagtgaggc     2252

caaagcactg tcctgtaagt cttacttcct gcttagggca cagtgaagta ggaaacaata     2312

ttttgaaaat aagttttaaa tttaaaatga tcaaaaagca atatagttgc ataaaagcac     2372

tgtaaaatat ttaaaaggtt aaaactgtgg aaaattatat tggtaagttt acagatcaat     2432

aaaagcacct gttctccatc tgaactagac aatggaaata atgctgcatg ctggccatgg     2492

cccattcttc atcatttgta agttcaacaa aagttctcac atggagtccc acctcttcag     2552

aggtttgtac atttgttttt aagcactgaa ttcactactg atcccatcgc ctggccagta     2612

gaacagtcat tactccatta acatcctcac tgtttagaca cataactgtg gtacagtgta     2672

ttggaaattt tataaacaaa agtgaaagtg ccaacaaatt attgatagct gataatgttt     2732

cattatctgc aactgcttga taagtatgtt gcattttaag agcttataat tgtgtataat     2792

ttgttaacac tagaaaccta ttagtattgt gaatgtagat tttactgtga agctatctgt     2852

gatttagctg tttgctccca tgatggagtc tttgcagcat ggcgctagca gccaatgcag     2912

tttctaatac tcggtaattt gcatgttttg tggagcattt ttatgtcacc aaccagacag     2972

tatttcctgc atgcttattt agaagaggca gcttatcttg agaggtagtg ttatctacct     3032

ttgtcaggct ttttgacagg tcatttcaga gtaagccttt gttcccaaga cccaacaact     3092

gtcaccctct tctgtacctc tcctgagtgc caactgtcca ggccatttga cacaccatct     3152

gttaacctct gagtttgccc actcaaggcc actcataggg gcatccatcc ccaagcacct     3212

cctcatgctg tgcatgcagt cttaaattca atggacaaaa ataaaatgct ggctacctct     3272

ggatcatctg gctgagcaac tgaattacaa aagagaatta cttccatctc aacttcaacc     3332

cattgattac gtccatccta gcaagctaaa tggcatccca gctgctcctt tctgtgcaac     3392

caattaaaga acaatgagtg tgatgctcca tgtctgaatt tcgtccagcc tctctctgaa     3452

ctgtgatctt tgtcctcatg aactttccct tttgttcatt gaactatatg gactcttcat     3512

ttcatattga tttactgtgc aatttacttt tggacattga gaacttgaaa ttatttcctg     3572

atcccttccc cttccactat taataattca tttctgtcaa actgtaagag tagactcatt     3632

tttttttttt tagtttttaa cattggactg ttatttcatt tagagttctc tatctctaaa     3692

tatttattta gagaatgatt ttaaaaggga atgatatgct tgtttaaatg aaagagaaaa     3752

gctgtagtaa actgtgttaa ttggtaatga ctatttatcg tcgatactct gtagctgtgt     3812

aagttttgac aaatagtgta tctcgtggaa tcagtggtta gcattgccgc tattatattt     3872

actcatttta tcattataaa tgtgcttagt tcatcatgta gcatca                    3918


<210>  198
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Met Ala Ala Ala Pro Ile Gln Gln Asn Gly Thr His Thr Gly Val 
1               5                   10                  15      


Pro Ile Asp Leu Asp Pro Pro Asp Ser Arg Lys Arg Pro Leu Glu Ala 
            20                  25                  30          


Pro Pro Glu Ala Gly Ser Thr Lys Arg Thr Asn Thr Gly Glu Asp Gly 
        35                  40                  45              


Gln Tyr Phe Leu Lys Val Leu Ile Pro Ser Tyr Ala Ala Gly Ser Ile 
    50                  55                  60                  


Ile Gly Lys Gly Gly Gln Thr Ile Val Gln Leu Gln Lys Glu Thr Gly 
65                  70                  75                  80  


Ala Thr Ile Lys Leu Ser Lys Ser Lys Asp Phe Tyr Pro Gly Thr Thr 
                85                  90                  95      


Glu Arg Val Cys Leu Ile Gln Gly Thr Val Glu Ala Leu Asn Ala Val 
            100                 105                 110         


His Gly Phe Ile Ala Glu Lys Ile Arg Glu Met Pro Gln Asn Val Ala 
        115                 120                 125             


Lys Thr Glu Pro Val Ser Ile Leu Gln Pro Gln Thr Thr Val Asn Pro 
    130                 135                 140                 


Asp Arg Ile Lys Gln Thr Leu Pro Ser Ser Pro Thr Thr Thr Lys Ser 
145                 150                 155                 160 


Ser Pro Ser Asp Pro Met Thr Thr Ser Arg Ala Asn Gln Val Lys Ile 
                165                 170                 175     


Ile Val Pro Asn Ser Thr Ala Gly Leu Ile Ile Gly Lys Gly Gly Ala 
            180                 185                 190         


Thr Val Lys Ala Val Met Glu Gln Ser Gly Ala Trp Val Gln Leu Ser 
        195                 200                 205             


Gln Lys Pro Asp Gly Ile Asn Leu Gln Glu Arg Val Val Thr Val Ser 
    210                 215                 220                 


Gly Glu Pro Glu Gln Asn Arg Lys Ala Val Glu Leu Ile Ile Gln Lys 
225                 230                 235                 240 


Ile Gln Glu Asp Pro Gln Ser Gly Ser Cys Leu Asn Ile Ser Tyr Ala 
                245                 250                 255     


Asn Val Thr Gly Pro Val Ala Asn Ser Asn Pro Thr Gly Ser Pro Tyr 
            260                 265                 270         


Ala Asn Thr Ala Glu Val Leu Pro Thr Ala Ala Ala Ala Ala Gly Leu 
        275                 280                 285             


Leu Gly His Ala Asn Leu Ala Gly Val Ala Ala Phe Pro Ala Val Leu 
    290                 295                 300                 


Ser Gly Phe Thr Gly Asn Asp Leu Val Ala Ile Thr Ser Ala Leu Asn 
305                 310                 315                 320 


Thr Leu Ala Ser Tyr Gly Tyr Asn Leu Asn Thr Leu Gly Leu Gly Leu 
                325                 330                 335     


Ser Gln Ala Ala Ala Thr Gly Ala Leu Ala Ala Ala Ala Ala Ser Ala 
            340                 345                 350         


Asn Pro Ala Ala Ala Ala Ala Asn Leu Leu Ala Thr Tyr Ala Ser Glu 
        355                 360                 365             


Ala Ser Ala Ser Gly Ser Thr Ala Gly Gly Thr Ala Gly Thr Phe Ala 
    370                 375                 380                 


Leu Gly Ser Leu Ala Ala Ala Thr Ala Ala Thr Asn Gly Tyr Phe Gly 
385                 390                 395                 400 


Ala Ala Ser Pro Leu Ala Ala Ser Ala Ile Leu Gly Thr Glu Lys Ser 
                405                 410                 415     


Thr Asp Gly Ser Lys Asp Val Val Glu Ile Ala Val Pro Glu Asn Leu 
            420                 425                 430         


Val Gly Ala Ile Leu Gly Lys Gly Gly Lys Thr Leu Val Glu Tyr Gln 
        435                 440                 445             


Glu Leu Thr Gly Ala Arg Ile Gln Ile Ser Lys Lys Gly Glu Phe Val 
    450                 455                 460                 


Pro Gly Thr Arg Asn Arg Lys Val Thr Ile Thr Gly Thr Pro Ala Ala 
465                 470                 475                 480 


Thr Gln Ala Ala Gln Tyr Leu Ile Thr Gln Arg Ile Thr Tyr Glu Gln 
                485                 490                 495     


Gly Val Arg Ala Ala Asn Pro Gln Lys Val Gly 
            500                 505         


<210>  199
<211>  2497
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (117)..(1268)

<400>  199
actggataag cggtcgctga gcggggcgca ggtgactaaa tttcgacggg gtcttctcac       60

gggtttcatt cagttggcca ctgctgagca gctgagaagg tggcgacgta ggggcc atg      119
                                                              Met         
                                                              1           

ggg ctg ggc cgg gtc ctg ctg ttt ctg gcc gtc gcc ttc cct ttt gca        167
Gly Leu Gly Arg Val Leu Leu Phe Leu Ala Val Ala Phe Pro Phe Ala           
            5                   10                  15                    

ccc ccg gca gcc gcc gct gag ccc cac agt ctt cgt tac aac ctc atg        215
Pro Pro Ala Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu Met           
        20                  25                  30                        

gtg ctg tcc cag gat gga tct gtg cag tca ggg ttt ctc gct gag gga        263
Val Leu Ser Gln Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu Gly           
    35                  40                  45                            

cat ctg gat ggt cag ccc ttc ctg cgc tat gac agg cag aaa cgc agg        311
His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg Arg           
50                  55                  60                  65            

gca aag ccc cag gga cag tgg gca gaa aat gtc ctg gga gct aag acc        359
Ala Lys Pro Gln Gly Gln Trp Ala Glu Asn Val Leu Gly Ala Lys Thr           
                70                  75                  80                

tgg gac aca gag acc gag gac ttg aca gag aat ggg caa gac ctc agg        407
Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu Arg           
            85                  90                  95                    

agg acc ctg act cat atc aag gac cag aaa gga ggc ttg cat tcc ctc        455
Arg Thr Leu Thr His Ile Lys Asp Gln Lys Gly Gly Leu His Ser Leu           
        100                 105                 110                       

cag gag att agg gtc tgt gag atc cat gaa gac agc agc acc agg ggc        503
Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Ser Ser Thr Arg Gly           
    115                 120                 125                           

tcc cgg cat ttc tac tac gat ggg gag ctc ttc ctc tcc caa aac ctg        551
Ser Arg His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu           
130                 135                 140                 145           

gag act caa gaa tcg aca gtg ccc cag tcc tcc aga gct cag acc ttg        599
Glu Thr Gln Glu Ser Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu           
                150                 155                 160               

gct atg aac gtc aca aat ttc tgg aag gaa gat gcc atg aag acc aag        647
Ala Met Asn Val Thr Asn Phe Trp Lys Glu Asp Ala Met Lys Thr Lys           
            165                 170                 175                   

aca cac tat cgc gct atg cag gca gac tgc ctg cag aaa cta cag cga        695
Thr His Tyr Arg Ala Met Gln Ala Asp Cys Leu Gln Lys Leu Gln Arg           
        180                 185                 190                       

tat ctg aaa tcc ggg gtg gcc atc agg aga aca gtg ccc ccc atg gtg        743
Tyr Leu Lys Ser Gly Val Ala Ile Arg Arg Thr Val Pro Pro Met Val           
    195                 200                 205                           

aat gtc acc tgc agc gag gtc tca gag ggc aac atc acc gtg aca tgc        791
Asn Val Thr Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr Cys           
210                 215                 220                 225           

agg gct tcc agc ttc tat ccc cgg aat atc aca ctg acc tgg cgt cag        839
Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg Gln           
                230                 235                 240               

gat ggg gta tct ttg agc cac aac acc cag cag tgg ggg gat gtc ctg        887
Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val Leu           
            245                 250                 255                   

cct gat ggg aat gga acc tac cag acc tgg gtg gcc acc agg att cgc        935
Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Arg           
        260                 265                 270                       

caa gga gag gag cag agg ttc acc tgc tac atg gaa cac agc ggg aat        983
Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn           
    275                 280                 285                           

cac ggc act cac cct gtg ccc tct ggg aag gcg ctg gtg ctt cag agt       1031
His Gly Thr His Pro Val Pro Ser Gly Lys Ala Leu Val Leu Gln Ser           
290                 295                 300                 305           

caa cgg aca gac ttt cca tat gtt tct gct gct atg cca tgt ttt gtt       1079
Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala Ala Met Pro Cys Phe Val           
                310                 315                 320               

att att att att ctc tgt gtc cct tgt tgc aag aag aaa aca tca gcg       1127
Ile Ile Ile Ile Leu Cys Val Pro Cys Cys Lys Lys Lys Thr Ser Ala           
            325                 330                 335                   

gca gag ggt cca gag ctt gtg agc ctg cag gtc ctg gat caa cac cca       1175
Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His Pro           
        340                 345                 350                       

gtt ggg aca gga gac cac agg gat gca gca cag ctg gga ttt cag cct       1223
Val Gly Thr Gly Asp His Arg Asp Ala Ala Gln Leu Gly Phe Gln Pro           
    355                 360                 365                           

ctg atg tca gct act ggg tcc act ggt tcc act gag ggc acc tag           1268
Leu Met Ser Ala Thr Gly Ser Thr Gly Ser Thr Glu Gly Thr                   
370                 375                 380                               

actctacagc caggcggcca ggattcaact ccctgcctgg atctcaccag cactttccct     1328

ctgtttcctg acctatgaaa cagagaaaat aacatcactt atttattgtt gttggatgct     1388

gcaaagtgtt agtaggtatg aggtgtttgc tgctctgcca cgtagagagc cagcaaaggg     1448

atcatgacca actcaacatt ccattggagg ctatatgatc aaacagcaaa ttgtttatca     1508

tgaatgcagg atgtgggcaa actcacgact gctcctgcca acagaaggtt tgctgagggc     1568

attcactcca tggtgctcat tggagttatc tactgggtca tctagagcct attgtttgag     1628

gaatgcagtc ttacaagcct actctggacc cagcagctga ctccttcttc cacccctctt     1688

cttgctatct cctataccaa taaatacgaa gggctgtgga agatcagagc ccttgttcac     1748

gagaagcaag aagccccctg accccttgtt ccaaatatac tcttttgtct ttctctttat     1808

tcccacgttc gccctttgtt cagtccaata cagggttgtg gggcccttaa cagtgccata     1868

ttaattggta tcattatttc tgttgttttt gtttttgttt ttgtttttgt ttttgagaca     1928

gagtctcact ctgtcaccca ggctgcagtt cactggtgtg atctcagctc actgcaacct     1988

ctgcctccca ggttcaagca cttctcgtac ctcagactcc cgaatagctg ggattacaga     2048

caggcaccac cacacccagc taatttttgt attttttgta gagacggggt ttcgccaagt     2108

tgaccagccc agtttcaaac tcctgacctc aggtgatctg cctgccttgg catcccaaag     2168

tgctgggatt acaagaatga gccaccgtgc ctggcctatt ttattatatt gtaatatatt     2228

ttattatatt agccaccatg cctgtcctat tttcttatgt tttaatatat tttaatatat     2288

tacatgtgca gtaattagat tatcatgggt gaactttatg agtgagtatc ttggtgatga     2348

ctcctcctga ccagcccagg accagctttc ttgtcacctt gaggtcccct cgccccgtca     2408

caccgttatg cattactctg tgtctactat tatgtgtgca taatttatac cgtaaatgtt     2468

tactctttaa atagaaaaaa aaaaaaaaa                                       2497


<210>  200
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Gly Leu Gly Arg Val Leu Leu Phe Leu Ala Val Ala Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Ala Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Met Val Leu Ser Gln Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Gly His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asn Val Leu Gly Ala Lys 
65                  70                  75                  80  


Thr Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu 
                85                  90                  95      


Arg Arg Thr Leu Thr His Ile Lys Asp Gln Lys Gly Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Ser Ser Thr Arg 
        115                 120                 125             


Gly Ser Arg His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Gln Glu Ser Thr Val Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Thr Asn Phe Trp Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr Arg Ala Met Gln Ala Asp Cys Leu Gln Lys Leu Gln 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Ala Ile Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Gly Thr His Pro Val Pro Ser Gly Lys Ala Leu Val Leu Gln 
    290                 295                 300                 


Ser Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala Ala Met Pro Cys Phe 
305                 310                 315                 320 


Val Ile Ile Ile Ile Leu Cys Val Pro Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Gly Asp His Arg Asp Ala Ala Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Ala Thr Gly Ser Thr Gly Ser Thr Glu Gly Thr 
    370                 375                 380             


<210>  201
<211>  998
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (58)..(414)

<400>  201
gggaacgggg cggagcgcgg ctgcgccggc gcgtcgaggg gagaggcagc agccgcg          57

atg gac gtg ttc ctc atg atc cgg cgc cac aag acc acc atc ttc acg        105
Met Asp Val Phe Leu Met Ile Arg Arg His Lys Thr Thr Ile Phe Thr           
1               5                   10                  15                

gac gcc aag gag tcc agc acg gtg ttc gaa ctg aag cgc atc gtc gag        153
Asp Ala Lys Glu Ser Ser Thr Val Phe Glu Leu Lys Arg Ile Val Glu           
            20                  25                  30                    

ggc atc ctc aag cgg cct cct gac gag cag cgg ctg tac aag gat gac        201
Gly Ile Leu Lys Arg Pro Pro Asp Glu Gln Arg Leu Tyr Lys Asp Asp           
        35                  40                  45                        

caa ctc ttg gat gat ggc aag aca ctg ggc gag tgt ggc ttc acc agt        249
Gln Leu Leu Asp Asp Gly Lys Thr Leu Gly Glu Cys Gly Phe Thr Ser           
    50                  55                  60                            

caa aca gca cgg cca cag gcc cca gcc aca gtg ggg ctg gcc ttc cgg        297
Gln Thr Ala Arg Pro Gln Ala Pro Ala Thr Val Gly Leu Ala Phe Arg           
65                  70                  75                  80            

gca gat gac acc ttt gag gcc ctg tgc atc gag ccg ttt tcc agc ccg        345
Ala Asp Asp Thr Phe Glu Ala Leu Cys Ile Glu Pro Phe Ser Ser Pro           
                85                  90                  95                

cca gag ctg ccc gat gtg atg aag ccc cag gac tcg gga agc agt gcc        393
Pro Glu Leu Pro Asp Val Met Lys Pro Gln Asp Ser Gly Ser Ser Ala           
            100                 105                 110                   

aat gaa caa gcc gtg cag tga ggacccccaa gaggcccatt tcccccaata           444
Asn Glu Gln Ala Val Gln                                                   
        115                                                               

aaagagattt gggagtctgc ctggttgctg cctctttttc ccgcccctcc ctgggatggg      504

tcccactccc tgtgggctcc ttttggggct tgtgcttggc agttcctgtg ctgtcctgtc      564

tcccagatcc tgagaccctg gctgagaact tggcccagcc tgctgcttaa aggcaccatg      624

gggacctggg ttgccctgag acccaagcca ttgttagcag ctagccagcc acaccaacca      684

cgccaggggg aggaaaggga aggactggga gagacacaaa gaccagagcc agcctcaggg      744

acaagagatt ccagttttag gcctttctcc ttctaagtgc cccccacccc catagcctgc      804

atgtccactc ccagacgatg gccaagagca gaaacacaag ctggagccag tgtcctggtt      864

tgacagcatg ttcaacgagg gaaccccaag acggacccac acaggtccac ccacgctggg      924

ggctgtaatc acggagggaa gtggctgccc ccttaacaca cctttaataa acagtctaca      984

gacccaaaaa aaaa                                                        998


<210>  202
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Asp Val Phe Leu Met Ile Arg Arg His Lys Thr Thr Ile Phe Thr 
1               5                   10                  15      


Asp Ala Lys Glu Ser Ser Thr Val Phe Glu Leu Lys Arg Ile Val Glu 
            20                  25                  30          


Gly Ile Leu Lys Arg Pro Pro Asp Glu Gln Arg Leu Tyr Lys Asp Asp 
        35                  40                  45              


Gln Leu Leu Asp Asp Gly Lys Thr Leu Gly Glu Cys Gly Phe Thr Ser 
    50                  55                  60                  


Gln Thr Ala Arg Pro Gln Ala Pro Ala Thr Val Gly Leu Ala Phe Arg 
65                  70                  75                  80  


Ala Asp Asp Thr Phe Glu Ala Leu Cys Ile Glu Pro Phe Ser Ser Pro 
                85                  90                  95      


Pro Glu Leu Pro Asp Val Met Lys Pro Gln Asp Ser Gly Ser Ser Ala 
            100                 105                 110         


Asn Glu Gln Ala Val Gln 
        115             


<210>  203
<211>  4085
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (142)..(2136)

<400>  203
agttttctcc aacatggccg cgcccagggg agatggcgtg caagtatccg ctgcggtgtt       60

ctggtgctag agtggagagg ctggcaaaga agaaggcaca cgcatggtga gaatccggcc      120

tgagccgaag cggagtttgc t atg gac agc aac cat caa agt aat tac aaa        171
                        Met Asp Ser Asn His Gln Ser Asn Tyr Lys           
                        1               5                   10            

ctc agt aaa act gag aag aag ttc tta agg aaa cag att aaa gcc aag        219
Leu Ser Lys Thr Glu Lys Lys Phe Leu Arg Lys Gln Ile Lys Ala Lys           
                15                  20                  25                

cat act ttg ctg aga cat gaa ggc att gag aca gta tcc tat gcc act        267
His Thr Leu Leu Arg His Glu Gly Ile Glu Thr Val Ser Tyr Ala Thr           
            30                  35                  40                    

cag agc ctg gtt gtt gcc aat ggt ggt ttg ggt aat ggt gtg agt cgg        315
Gln Ser Leu Val Val Ala Asn Gly Gly Leu Gly Asn Gly Val Ser Arg           
        45                  50                  55                        

aac cag ctg ctc ccg gtt tta gag aaa tgt gga ctg gtg gat gct ctc        363
Asn Gln Leu Leu Pro Val Leu Glu Lys Cys Gly Leu Val Asp Ala Leu           
    60                  65                  70                            

tta atg cca cct aac aag ccg tac tca ttt gca aga tac aga act aca        411
Leu Met Pro Pro Asn Lys Pro Tyr Ser Phe Ala Arg Tyr Arg Thr Thr           
75                  80                  85                  90            

gaa gaa tct aag aga gcc tat gtt acc ctc aat gga aaa gaa gta gtg        459
Glu Glu Ser Lys Arg Ala Tyr Val Thr Leu Asn Gly Lys Glu Val Val           
                95                  100                 105               

gat gat tta gga caa aag atc act ctg tat ttg aat ttt gtg gaa aaa        507
Asp Asp Leu Gly Gln Lys Ile Thr Leu Tyr Leu Asn Phe Val Glu Lys           
            110                 115                 120                   

gtg cag tgg aag gag ttg agg cct caa gcc tta cca cca gga ctc atg        555
Val Gln Trp Lys Glu Leu Arg Pro Gln Ala Leu Pro Pro Gly Leu Met           
        125                 130                 135                       

gta gta gaa gaa ata att tct tct gag gag gag aaa atg ctt ttg gaa        603
Val Val Glu Glu Ile Ile Ser Ser Glu Glu Glu Lys Met Leu Leu Glu           
    140                 145                 150                           

agt gtt gat tgg aca gaa gat aca gac aat caa aac tct caa aaa tcc        651
Ser Val Asp Trp Thr Glu Asp Thr Asp Asn Gln Asn Ser Gln Lys Ser           
155                 160                 165                 170           

tta aaa cac aga aga gta aag cat ttt ggt tat gag ttc cac tat gag        699
Leu Lys His Arg Arg Val Lys His Phe Gly Tyr Glu Phe His Tyr Glu           
                175                 180                 185               

aac aac aat gta gat aaa gat aag cca tta tct ggg ggt ctt cct gac        747
Asn Asn Asn Val Asp Lys Asp Lys Pro Leu Ser Gly Gly Leu Pro Asp           
            190                 195                 200                   

att tgt gaa agc ttt ttg gag aaa tgg ttg agg aaa ggt tac att aaa        795
Ile Cys Glu Ser Phe Leu Glu Lys Trp Leu Arg Lys Gly Tyr Ile Lys           
        205                 210                 215                       

cat aaa cct gat caa atg acc ata aat cag tat gaa cct ggg caa gga        843
His Lys Pro Asp Gln Met Thr Ile Asn Gln Tyr Glu Pro Gly Gln Gly           
    220                 225                 230                           

att ccc gct cat att gat aca cat tcc gct ttt gag gat gag atc gtt        891
Ile Pro Ala His Ile Asp Thr His Ser Ala Phe Glu Asp Glu Ile Val           
235                 240                 245                 250           

tct ctc agt ttg ggg tca gag att gtc atg gat ttt aag cac cca gat        939
Ser Leu Ser Leu Gly Ser Glu Ile Val Met Asp Phe Lys His Pro Asp           
                255                 260                 265               

ggc att gca gtg cca gtt atg ttg cct cgt cgg agt ttg ctg gtg atg        987
Gly Ile Ala Val Pro Val Met Leu Pro Arg Arg Ser Leu Leu Val Met           
            270                 275                 280                   

aca gga gaa tct aga tac ctt tgg acc cat gga atc acg tgc aga aaa       1035
Thr Gly Glu Ser Arg Tyr Leu Trp Thr His Gly Ile Thr Cys Arg Lys           
        285                 290                 295                       

ttt gat act gtt caa gca tct gag agt ctt aaa agt gga att atc acc       1083
Phe Asp Thr Val Gln Ala Ser Glu Ser Leu Lys Ser Gly Ile Ile Thr           
    300                 305                 310                           

agt gat gtt gga gac tta act tta agc aag agg gga cta cga aca tca       1131
Ser Asp Val Gly Asp Leu Thr Leu Ser Lys Arg Gly Leu Arg Thr Ser           
315                 320                 325                 330           

ttt aca ttt agg aaa gtg agg caa aca cct tgt aac tgt agt tac ccg       1179
Phe Thr Phe Arg Lys Val Arg Gln Thr Pro Cys Asn Cys Ser Tyr Pro           
                335                 340                 345               

ttg gtc tgt gat agc cag agg aaa gag act ccc ccc tca ttt cca gag       1227
Leu Val Cys Asp Ser Gln Arg Lys Glu Thr Pro Pro Ser Phe Pro Glu           
            350                 355                 360                   

agt gat aaa gaa gcc tca cgg ctg gag caa gag tac gtc cat cag gtt       1275
Ser Asp Lys Glu Ala Ser Arg Leu Glu Gln Glu Tyr Val His Gln Val           
        365                 370                 375                       

tat gaa gag att gct ggg cac ttc agc agc aca aga cat acc cct tgg       1323
Tyr Glu Glu Ile Ala Gly His Phe Ser Ser Thr Arg His Thr Pro Trp           
    380                 385                 390                           

ccg cac att gtg gag ttt ttg aag gct ttg cca agt ggt tca ata gtg       1371
Pro His Ile Val Glu Phe Leu Lys Ala Leu Pro Ser Gly Ser Ile Val           
395                 400                 405                 410           

gct gat att gga tgt ggt aat gga aag tat ctt ggc atc aat aag gag       1419
Ala Asp Ile Gly Cys Gly Asn Gly Lys Tyr Leu Gly Ile Asn Lys Glu           
                415                 420                 425               

tta tat atg att ggt tgt gat cgt agc caa aac ctt gtg gac att tgt       1467
Leu Tyr Met Ile Gly Cys Asp Arg Ser Gln Asn Leu Val Asp Ile Cys           
            430                 435                 440                   

aga gag agg caa ttt cag gct ttt gtc tgt gat gca ttg gca gta cca       1515
Arg Glu Arg Gln Phe Gln Ala Phe Val Cys Asp Ala Leu Ala Val Pro           
        445                 450                 455                       

gtc cgc agt ggg tct tgt gat gcc tgc atc tcc att gct gtt att cat       1563
Val Arg Ser Gly Ser Cys Asp Ala Cys Ile Ser Ile Ala Val Ile His           
    460                 465                 470                           

cat ttt gca aca gca gag cgt aga gtg gca gct ctc caa gaa att gtt       1611
His Phe Ala Thr Ala Glu Arg Arg Val Ala Ala Leu Gln Glu Ile Val           
475                 480                 485                 490           

cga ctc ctg aga cca ggt ggg aag gca ctc att tat gtc tgg gca atg       1659
Arg Leu Leu Arg Pro Gly Gly Lys Ala Leu Ile Tyr Val Trp Ala Met           
                495                 500                 505               

gaa caa gaa tat aat aag cag aag tcc aag tat ctt aga gga aac aga       1707
Glu Gln Glu Tyr Asn Lys Gln Lys Ser Lys Tyr Leu Arg Gly Asn Arg           
            510                 515                 520                   

aat agc caa gga aag aaa gag gag atg aac agt gat acc tca gtg cag       1755
Asn Ser Gln Gly Lys Lys Glu Glu Met Asn Ser Asp Thr Ser Val Gln           
        525                 530                 535                       

agg tca ctt gtg gag caa atg cgt gac atg ggc agt cga gac tcg gca       1803
Arg Ser Leu Val Glu Gln Met Arg Asp Met Gly Ser Arg Asp Ser Ala           
    540                 545                 550                           

tct tct gtc ccc cgc att aat gac tct cag gaa gga gga tgt aat tca       1851
Ser Ser Val Pro Arg Ile Asn Asp Ser Gln Glu Gly Gly Cys Asn Ser           
555                 560                 565                 570           

agg caa gtt tct aat tcc aag ctg cct gtt cat gtt aac agg act tct       1899
Arg Gln Val Ser Asn Ser Lys Leu Pro Val His Val Asn Arg Thr Ser           
                575                 580                 585               

ttt tat tct caa gat gta ctg gtt ccc tgg cac ctt aag gga aat cct       1947
Phe Tyr Ser Gln Asp Val Leu Val Pro Trp His Leu Lys Gly Asn Pro           
            590                 595                 600                   

gat aaa ggc aaa cct gtt gag cca ttt ggt ccc ata gga tcc cag gac       1995
Asp Lys Gly Lys Pro Val Glu Pro Phe Gly Pro Ile Gly Ser Gln Asp           
        605                 610                 615                       

cca agt cct gtg ttt cat cgt tac tac cat gtg ttc cgt gag gga gaa       2043
Pro Ser Pro Val Phe His Arg Tyr Tyr His Val Phe Arg Glu Gly Glu           
    620                 625                 630                           

ctg gaa ggt gcc tgc agg act gtg agt gat gtc aga att ctg caa agc       2091
Leu Glu Gly Ala Cys Arg Thr Val Ser Asp Val Arg Ile Leu Gln Ser           
635                 640                 645                 650           

tac tac gat caa gga aac tgg tgt gtg att ctt caa aag gcc tga           2136
Tyr Tyr Asp Gln Gly Asn Trp Cys Val Ile Leu Gln Lys Ala                   
                655                 660                                   

ttatttacct gaacacatca tatataaaga agaaatgctc acttaaaaaa aaagagagaa     2196

taaattaatt acccttttaa ttaaagagaa aacttgtggg aaagtaccaa aggaaagctg     2256

agaaaaattt ggaagtaggg attcattagg agacattcaa atgtctcctg ttggctgaca     2316

tcacagatgt ggtgttggct cctcctactt ccctaggaga ggtggtttct aaaagtgatt     2376

gaagcagttt gtgcagtgtt tgtaattctt gggtaagagc ccaggatttt gaagataata     2436

gttttttagt aaagtgctac taaatgtagt aaatcatgta ggattttagg gatgtaatta     2496

tatgttaata cagaaaatag tcctggtcaa tagaaaattg tctgaagttt tacctatgat     2556

ttttagctct gtaaaatcat agacaataac cattctattt ccatgcctga ctagcccagg     2616

gctggacgta tagcgggtgt ccaataacgt ttagtcaatc agataatacc cagaacttag     2676

taggagtttc attcaaaaac tattttttga acccaaccat gtaccagtta ctattttaag     2736

tactgataat gaagcagtga ataagaaaga gcaaagctct tgcccttatg gtgcttacat     2796

tctagacggg gagacagaca gcaggcaaat caataaatag atactatgtg ccagatagtg     2856

ataaatgcca tgaaaaacat aaaatgagag acgattcacc ttggagcaaa agattacttt     2916

taagtgactg aaataactac taatcctgac taatttatta tcaagagtta attggtattc     2976

caaattcatt gagcagggtg ctaaaaacaa cccaaatgtg ctcctttaac tcctttgttt     3036

aaatgacaaa agttagaatg tggtcactca gacctaactg tgcccttaga gccaaagctg     3096

tggtgtcatt attggttatt tctagttgat tcatagtttg tcccaatcca ggttcaatcg     3156

ggttattttt aagatctgta caatattgca taatagtaac ccagttaact taccacttag     3216

gttagatttc ctggaggaac aaaggtagaa attcaaccat aggtcaaatt atcacataga     3276

aggaaaaggc tttttttcaa agaaaaaatt ttttgaacac tttactccca gtatgcatta     3336

cttttgtagt agtaatgctt aagactgttt taaagaaaaa ttgctttctg tttaattaat     3396

gtttactgtt attaatgcta gtgatactta atcttgaagc atcaagtttt cagaaaccta     3456

tagtgatcaa taatgggtct cagatgagag gatgattatt tttttcatgg aatttcagtc     3516

caacatcctg gtgtactggt ccctctggga tgaatttata aggctcatga tataggaaaa     3576

ggaatatagg gctaaaaata gttttatttc tgatataaat tctggtactt gacaccaaag     3636

tttgaagtca agtcatgcca ataaatttta acatccaaat gaaatagatg attttctatg     3696

aagatgaaaa ataccaaaat tgactcaaga agggagagaa aatggaagat gttgaaaaat     3756

agcataggaa ttcagaactg ggctctagaa tcagatttcc tgagagttga attctagatc     3816

tgccatttat tagctgtggg attttgggca aatttcttga ctttctgtgc ttcagttttc     3876

ttagctgtaa aattggaaga gttgttatga aaattcactg aaagtatatt tgtatacatc     3936

ataggatagt gtaagaatat agtatggctt tgagaaatgt tcattattat tactcccaga     3996

ggagttttag gtattaagtg atgccaaata taatttgtta attgtataat aaaaatctat     4056

attcttactg aaaaaaaaaa aaaaaaaaa                                       4085


<210>  204
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Asp Ser Asn His Gln Ser Asn Tyr Lys Leu Ser Lys Thr Glu Lys 
1               5                   10                  15      


Lys Phe Leu Arg Lys Gln Ile Lys Ala Lys His Thr Leu Leu Arg His 
            20                  25                  30          


Glu Gly Ile Glu Thr Val Ser Tyr Ala Thr Gln Ser Leu Val Val Ala 
        35                  40                  45              


Asn Gly Gly Leu Gly Asn Gly Val Ser Arg Asn Gln Leu Leu Pro Val 
    50                  55                  60                  


Leu Glu Lys Cys Gly Leu Val Asp Ala Leu Leu Met Pro Pro Asn Lys 
65                  70                  75                  80  


Pro Tyr Ser Phe Ala Arg Tyr Arg Thr Thr Glu Glu Ser Lys Arg Ala 
                85                  90                  95      


Tyr Val Thr Leu Asn Gly Lys Glu Val Val Asp Asp Leu Gly Gln Lys 
            100                 105                 110         


Ile Thr Leu Tyr Leu Asn Phe Val Glu Lys Val Gln Trp Lys Glu Leu 
        115                 120                 125             


Arg Pro Gln Ala Leu Pro Pro Gly Leu Met Val Val Glu Glu Ile Ile 
    130                 135                 140                 


Ser Ser Glu Glu Glu Lys Met Leu Leu Glu Ser Val Asp Trp Thr Glu 
145                 150                 155                 160 


Asp Thr Asp Asn Gln Asn Ser Gln Lys Ser Leu Lys His Arg Arg Val 
                165                 170                 175     


Lys His Phe Gly Tyr Glu Phe His Tyr Glu Asn Asn Asn Val Asp Lys 
            180                 185                 190         


Asp Lys Pro Leu Ser Gly Gly Leu Pro Asp Ile Cys Glu Ser Phe Leu 
        195                 200                 205             


Glu Lys Trp Leu Arg Lys Gly Tyr Ile Lys His Lys Pro Asp Gln Met 
    210                 215                 220                 


Thr Ile Asn Gln Tyr Glu Pro Gly Gln Gly Ile Pro Ala His Ile Asp 
225                 230                 235                 240 


Thr His Ser Ala Phe Glu Asp Glu Ile Val Ser Leu Ser Leu Gly Ser 
                245                 250                 255     


Glu Ile Val Met Asp Phe Lys His Pro Asp Gly Ile Ala Val Pro Val 
            260                 265                 270         


Met Leu Pro Arg Arg Ser Leu Leu Val Met Thr Gly Glu Ser Arg Tyr 
        275                 280                 285             


Leu Trp Thr His Gly Ile Thr Cys Arg Lys Phe Asp Thr Val Gln Ala 
    290                 295                 300                 


Ser Glu Ser Leu Lys Ser Gly Ile Ile Thr Ser Asp Val Gly Asp Leu 
305                 310                 315                 320 


Thr Leu Ser Lys Arg Gly Leu Arg Thr Ser Phe Thr Phe Arg Lys Val 
                325                 330                 335     


Arg Gln Thr Pro Cys Asn Cys Ser Tyr Pro Leu Val Cys Asp Ser Gln 
            340                 345                 350         


Arg Lys Glu Thr Pro Pro Ser Phe Pro Glu Ser Asp Lys Glu Ala Ser 
        355                 360                 365             


Arg Leu Glu Gln Glu Tyr Val His Gln Val Tyr Glu Glu Ile Ala Gly 
    370                 375                 380                 


His Phe Ser Ser Thr Arg His Thr Pro Trp Pro His Ile Val Glu Phe 
385                 390                 395                 400 


Leu Lys Ala Leu Pro Ser Gly Ser Ile Val Ala Asp Ile Gly Cys Gly 
                405                 410                 415     


Asn Gly Lys Tyr Leu Gly Ile Asn Lys Glu Leu Tyr Met Ile Gly Cys 
            420                 425                 430         


Asp Arg Ser Gln Asn Leu Val Asp Ile Cys Arg Glu Arg Gln Phe Gln 
        435                 440                 445             


Ala Phe Val Cys Asp Ala Leu Ala Val Pro Val Arg Ser Gly Ser Cys 
    450                 455                 460                 


Asp Ala Cys Ile Ser Ile Ala Val Ile His His Phe Ala Thr Ala Glu 
465                 470                 475                 480 


Arg Arg Val Ala Ala Leu Gln Glu Ile Val Arg Leu Leu Arg Pro Gly 
                485                 490                 495     


Gly Lys Ala Leu Ile Tyr Val Trp Ala Met Glu Gln Glu Tyr Asn Lys 
            500                 505                 510         


Gln Lys Ser Lys Tyr Leu Arg Gly Asn Arg Asn Ser Gln Gly Lys Lys 
        515                 520                 525             


Glu Glu Met Asn Ser Asp Thr Ser Val Gln Arg Ser Leu Val Glu Gln 
    530                 535                 540                 


Met Arg Asp Met Gly Ser Arg Asp Ser Ala Ser Ser Val Pro Arg Ile 
545                 550                 555                 560 


Asn Asp Ser Gln Glu Gly Gly Cys Asn Ser Arg Gln Val Ser Asn Ser 
                565                 570                 575     


Lys Leu Pro Val His Val Asn Arg Thr Ser Phe Tyr Ser Gln Asp Val 
            580                 585                 590         


Leu Val Pro Trp His Leu Lys Gly Asn Pro Asp Lys Gly Lys Pro Val 
        595                 600                 605             


Glu Pro Phe Gly Pro Ile Gly Ser Gln Asp Pro Ser Pro Val Phe His 
    610                 615                 620                 


Arg Tyr Tyr His Val Phe Arg Glu Gly Glu Leu Glu Gly Ala Cys Arg 
625                 630                 635                 640 


Thr Val Ser Asp Val Arg Ile Leu Gln Ser Tyr Tyr Asp Gln Gly Asn 
                645                 650                 655     


Trp Cys Val Ile Leu Gln Lys Ala 
            660                 


<210>  205
<211>  2828
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (219)..(2051)

<400>  205
cgcacgcgcg gttagtagtc gctgctgcgc ggccgccggc gggactggtc tgaagagacg       60

cggggaccaa gtggcaacga cttggacatc tgagctgtca ctgccgaaaa caggccgcaa      120

gagagcatct gcccaagcaa caaagaggag gtgtttgctt gggagttaaa agcaaatggc      180

aaccaaagct caggactggg agagaaaaga taatcaat atg cat ttc caa gcc ttt      236
                                          Met His Phe Gln Ala Phe         
                                          1               5               

tgg cta tgt ttg ggt ctt ctg ttc atc tca att aat gca gaa ttt atg        284
Trp Leu Cys Leu Gly Leu Leu Phe Ile Ser Ile Asn Ala Glu Phe Met           
            10                  15                  20                    

gat gat gat gtt gag acg gaa gac ttt gaa gaa aat tca gaa gaa att        332
Asp Asp Asp Val Glu Thr Glu Asp Phe Glu Glu Asn Ser Glu Glu Ile           
        25                  30                  35                        

gat gtt aat gaa agt gaa ctt tcc tca gag att aaa tat aag aca cct        380
Asp Val Asn Glu Ser Glu Leu Ser Ser Glu Ile Lys Tyr Lys Thr Pro           
    40                  45                  50                            

caa cct ata gga gaa gta tat ttt gca gaa act ttt gat agt gga agg        428
Gln Pro Ile Gly Glu Val Tyr Phe Ala Glu Thr Phe Asp Ser Gly Arg           
55                  60                  65                  70            

ttg gct gga tgg gtc tta tca aaa gca aag aaa gat gac atg gat gag        476
Leu Ala Gly Trp Val Leu Ser Lys Ala Lys Lys Asp Asp Met Asp Glu           
                75                  80                  85                

gaa att tca ata tac gat gga aga tgg gaa att gaa gag ttg aaa gaa        524
Glu Ile Ser Ile Tyr Asp Gly Arg Trp Glu Ile Glu Glu Leu Lys Glu           
            90                  95                  100                   

aac cag gta cct ggt gac aga gga ctg gta tta aaa tct aga gca aag        572
Asn Gln Val Pro Gly Asp Arg Gly Leu Val Leu Lys Ser Arg Ala Lys           
        105                 110                 115                       

cat cat gca ata tct gct gta tta gca aaa cca ttc att ttt gct gat        620
His His Ala Ile Ser Ala Val Leu Ala Lys Pro Phe Ile Phe Ala Asp           
    120                 125                 130                           

aaa ccc ttg ata gtt caa tat gaa gta aat ttt caa gat ggt att gat        668
Lys Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asp Gly Ile Asp           
135                 140                 145                 150           

tgt gga ggt gca tac att aaa ctc cta gca gac act gat gat ttg att        716
Cys Gly Gly Ala Tyr Ile Lys Leu Leu Ala Asp Thr Asp Asp Leu Ile           
                155                 160                 165               

ctg gaa aac ttt tat gat aaa aca tcc tat atc att atg ttt gga cca        764
Leu Glu Asn Phe Tyr Asp Lys Thr Ser Tyr Ile Ile Met Phe Gly Pro           
            170                 175                 180                   

gat aaa tgt gga gaa gat tat aaa ctt cat ttt atc ttc aga cat aaa        812
Asp Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys           
        185                 190                 195                       

cat ccc aaa act gga gtt ttc gaa gag aaa cat gcc aaa cct cca gat        860
His Pro Lys Thr Gly Val Phe Glu Glu Lys His Ala Lys Pro Pro Asp           
    200                 205                 210                           

gta gac ctt aaa aag ttc ttt aca gac agg aag act cat ctt tat acc        908
Val Asp Leu Lys Lys Phe Phe Thr Asp Arg Lys Thr His Leu Tyr Thr           
215                 220                 225                 230           

ctt gtg atg aat cca gat gac aca ttt gag gtg tta gtt gat caa aca        956
Leu Val Met Asn Pro Asp Asp Thr Phe Glu Val Leu Val Asp Gln Thr           
                235                 240                 245               

gtt gta aac aaa gga agc ctc cta gag gat gtg gtt cct cct atc aaa       1004
Val Val Asn Lys Gly Ser Leu Leu Glu Asp Val Val Pro Pro Ile Lys           
            250                 255                 260                   

cct ccc aaa gaa att gaa gat ccc aat gat aaa aaa cct gag gaa tgg       1052
Pro Pro Lys Glu Ile Glu Asp Pro Asn Asp Lys Lys Pro Glu Glu Trp           
        265                 270                 275                       

gat gaa aga gca aaa att cct gat cct tct gcc gtc aaa cca gaa gac       1100
Asp Glu Arg Ala Lys Ile Pro Asp Pro Ser Ala Val Lys Pro Glu Asp           
    280                 285                 290                           

tgg gat gaa agt gaa cct gcc caa ata gaa gat tca agt gtt gtt aaa       1148
Trp Asp Glu Ser Glu Pro Ala Gln Ile Glu Asp Ser Ser Val Val Lys           
295                 300                 305                 310           

cct gct ggc tgg ctt gat gat gaa cca aaa ttt atc cct gat cct aat       1196
Pro Ala Gly Trp Leu Asp Asp Glu Pro Lys Phe Ile Pro Asp Pro Asn           
                315                 320                 325               

gct gaa aaa cct gat gac tgg aat gaa gac acg gat gga gaa tgg gag       1244
Ala Glu Lys Pro Asp Asp Trp Asn Glu Asp Thr Asp Gly Glu Trp Glu           
            330                 335                 340                   

gca cct cag att ctt aat cca gca tgt cgg att ggg tgt ggt gag tgg       1292
Ala Pro Gln Ile Leu Asn Pro Ala Cys Arg Ile Gly Cys Gly Glu Trp           
        345                 350                 355                       

aaa cct ccc atg ata gat aac cca aaa tac aaa gga gta tgg aga cct       1340
Lys Pro Pro Met Ile Asp Asn Pro Lys Tyr Lys Gly Val Trp Arg Pro           
    360                 365                 370                           

cca ctg gtc gat aat cct aac tat cag gga atc tgg agt cct cga aaa       1388
Pro Leu Val Asp Asn Pro Asn Tyr Gln Gly Ile Trp Ser Pro Arg Lys           
375                 380                 385                 390           

att cct aat cca gat tat ttc gaa gat gat cat cca ttt ctt ctg act       1436
Ile Pro Asn Pro Asp Tyr Phe Glu Asp Asp His Pro Phe Leu Leu Thr           
                395                 400                 405               

tct ttc agt gct ctt ggt tta gag ctt tgg tct atg acc tct gat atc       1484
Ser Phe Ser Ala Leu Gly Leu Glu Leu Trp Ser Met Thr Ser Asp Ile           
            410                 415                 420                   

tac ttt gat aat ttt att atc tgt tcg gaa aag gaa gta gca gat cac       1532
Tyr Phe Asp Asn Phe Ile Ile Cys Ser Glu Lys Glu Val Ala Asp His           
        425                 430                 435                       

tgg gct gca gat ggt tgg aga tgg aaa ata atg ata gca aat gct aat       1580
Trp Ala Ala Asp Gly Trp Arg Trp Lys Ile Met Ile Ala Asn Ala Asn           
    440                 445                 450                           

aag cct ggt gta tta aaa cag tta atg gca gct gct gaa ggg cac cca       1628
Lys Pro Gly Val Leu Lys Gln Leu Met Ala Ala Ala Glu Gly His Pro           
455                 460                 465                 470           

tgg ctt tgg ttg att tat ctt gtg aca gca gga gtg cca ata gca tta       1676
Trp Leu Trp Leu Ile Tyr Leu Val Thr Ala Gly Val Pro Ile Ala Leu           
                475                 480                 485               

att act tca ttt tgt tgg cca aga aaa gta aag aaa aaa cat aaa gat       1724
Ile Thr Ser Phe Cys Trp Pro Arg Lys Val Lys Lys Lys His Lys Asp           
            490                 495                 500                   

aca gag tat aaa aaa acc gac ata tgt ata cca caa aca aaa gga gta       1772
Thr Glu Tyr Lys Lys Thr Asp Ile Cys Ile Pro Gln Thr Lys Gly Val           
        505                 510                 515                       

cta gag caa gaa gaa aag gaa gag aaa gca gcc ctg gaa aaa cca atg       1820
Leu Glu Gln Glu Glu Lys Glu Glu Lys Ala Ala Leu Glu Lys Pro Met           
    520                 525                 530                           

gac ctg gaa gag gaa aaa aag caa aat gat ggt gaa atg ctt gaa aaa       1868
Asp Leu Glu Glu Glu Lys Lys Gln Asn Asp Gly Glu Met Leu Glu Lys           
535                 540                 545                 550           

gaa gag gaa agt gaa cct gag gaa aag agt gaa gaa gaa att gaa atc       1916
Glu Glu Glu Ser Glu Pro Glu Glu Lys Ser Glu Glu Glu Ile Glu Ile           
                555                 560                 565               

ata gaa ggg caa gaa gaa agt aat caa tca aat aag tct ggg tca gag       1964
Ile Glu Gly Gln Glu Glu Ser Asn Gln Ser Asn Lys Ser Gly Ser Glu           
            570                 575                 580                   

gat gag atg aaa gaa gca gat gag agc aca gga tct gga gat ggg ccg       2012
Asp Glu Met Lys Glu Ala Asp Glu Ser Thr Gly Ser Gly Asp Gly Pro           
        585                 590                 595                       

ata aag tca gta cgc aaa aga aga gta cga aag gac taa actagattga        2061
Ile Lys Ser Val Arg Lys Arg Arg Val Arg Lys Asp                           
    600                 605                 610                           

aatattttta attcccgaga gggatgtttg gcattgtaaa aatcagcatg ccagacctga     2121

actttaatca gtctgcacat cctgtttcta atatctagca acattatatt ctttcagaca     2181

tttattttag tccttcattt cagaggaaaa agaagcaact ttgaagttac ctcatctttg     2241

aatttagaat aaaagtggca cattacatat cggatctaag agattaatac cattagaagt     2301

tacacagttt tagttgtttg gagatagttt tggtttgtac agaacaaaat aatatgtagc     2361

agcttcattg ctattggaaa aatcagttat tggaatttcc acttaaatgg ctatacaaca     2421

atataactgg tagttctata ataaaaatga gcatatgttc tgttgtgaag agctaaatgc     2481

aataaagttt ctgtatggtt gtttgattct atcaacaatt gaaagtgttg tatatgaccc     2541

acatttacct agtttgtgtc aaattatagt tacagtgagt tgtttgctta aattatagat     2601

tcctttaagg acatgccttg ttcataaaat cactggatta tattgcagca tattttacat     2661

ttgaatacaa ggataatggg ttttatcaaa acaaaatgat gtacagattt tttttcaagt     2721

ttttatagtt gctttatgcc agagtggttt accccattca caaaatttct tatgcataca     2781

ttgctattga aaataaaatt taaatatttt ttcatcctga aaaaaaa                   2828


<210>  206
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  206

Met His Phe Gln Ala Phe Trp Leu Cys Leu Gly Leu Leu Phe Ile Ser 
1               5                   10                  15      


Ile Asn Ala Glu Phe Met Asp Asp Asp Val Glu Thr Glu Asp Phe Glu 
            20                  25                  30          


Glu Asn Ser Glu Glu Ile Asp Val Asn Glu Ser Glu Leu Ser Ser Glu 
        35                  40                  45              


Ile Lys Tyr Lys Thr Pro Gln Pro Ile Gly Glu Val Tyr Phe Ala Glu 
    50                  55                  60                  


Thr Phe Asp Ser Gly Arg Leu Ala Gly Trp Val Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Lys Asp Asp Met Asp Glu Glu Ile Ser Ile Tyr Asp Gly Arg Trp Glu 
                85                  90                  95      


Ile Glu Glu Leu Lys Glu Asn Gln Val Pro Gly Asp Arg Gly Leu Val 
            100                 105                 110         


Leu Lys Ser Arg Ala Lys His His Ala Ile Ser Ala Val Leu Ala Lys 
        115                 120                 125             


Pro Phe Ile Phe Ala Asp Lys Pro Leu Ile Val Gln Tyr Glu Val Asn 
    130                 135                 140                 


Phe Gln Asp Gly Ile Asp Cys Gly Gly Ala Tyr Ile Lys Leu Leu Ala 
145                 150                 155                 160 


Asp Thr Asp Asp Leu Ile Leu Glu Asn Phe Tyr Asp Lys Thr Ser Tyr 
                165                 170                 175     


Ile Ile Met Phe Gly Pro Asp Lys Cys Gly Glu Asp Tyr Lys Leu His 
            180                 185                 190         


Phe Ile Phe Arg His Lys His Pro Lys Thr Gly Val Phe Glu Glu Lys 
        195                 200                 205             


His Ala Lys Pro Pro Asp Val Asp Leu Lys Lys Phe Phe Thr Asp Arg 
    210                 215                 220                 


Lys Thr His Leu Tyr Thr Leu Val Met Asn Pro Asp Asp Thr Phe Glu 
225                 230                 235                 240 


Val Leu Val Asp Gln Thr Val Val Asn Lys Gly Ser Leu Leu Glu Asp 
                245                 250                 255     


Val Val Pro Pro Ile Lys Pro Pro Lys Glu Ile Glu Asp Pro Asn Asp 
            260                 265                 270         


Lys Lys Pro Glu Glu Trp Asp Glu Arg Ala Lys Ile Pro Asp Pro Ser 
        275                 280                 285             


Ala Val Lys Pro Glu Asp Trp Asp Glu Ser Glu Pro Ala Gln Ile Glu 
    290                 295                 300                 


Asp Ser Ser Val Val Lys Pro Ala Gly Trp Leu Asp Asp Glu Pro Lys 
305                 310                 315                 320 


Phe Ile Pro Asp Pro Asn Ala Glu Lys Pro Asp Asp Trp Asn Glu Asp 
                325                 330                 335     


Thr Asp Gly Glu Trp Glu Ala Pro Gln Ile Leu Asn Pro Ala Cys Arg 
            340                 345                 350         


Ile Gly Cys Gly Glu Trp Lys Pro Pro Met Ile Asp Asn Pro Lys Tyr 
        355                 360                 365             


Lys Gly Val Trp Arg Pro Pro Leu Val Asp Asn Pro Asn Tyr Gln Gly 
    370                 375                 380                 


Ile Trp Ser Pro Arg Lys Ile Pro Asn Pro Asp Tyr Phe Glu Asp Asp 
385                 390                 395                 400 


His Pro Phe Leu Leu Thr Ser Phe Ser Ala Leu Gly Leu Glu Leu Trp 
                405                 410                 415     


Ser Met Thr Ser Asp Ile Tyr Phe Asp Asn Phe Ile Ile Cys Ser Glu 
            420                 425                 430         


Lys Glu Val Ala Asp His Trp Ala Ala Asp Gly Trp Arg Trp Lys Ile 
        435                 440                 445             


Met Ile Ala Asn Ala Asn Lys Pro Gly Val Leu Lys Gln Leu Met Ala 
    450                 455                 460                 


Ala Ala Glu Gly His Pro Trp Leu Trp Leu Ile Tyr Leu Val Thr Ala 
465                 470                 475                 480 


Gly Val Pro Ile Ala Leu Ile Thr Ser Phe Cys Trp Pro Arg Lys Val 
                485                 490                 495     


Lys Lys Lys His Lys Asp Thr Glu Tyr Lys Lys Thr Asp Ile Cys Ile 
            500                 505                 510         


Pro Gln Thr Lys Gly Val Leu Glu Gln Glu Glu Lys Glu Glu Lys Ala 
        515                 520                 525             


Ala Leu Glu Lys Pro Met Asp Leu Glu Glu Glu Lys Lys Gln Asn Asp 
    530                 535                 540                 


Gly Glu Met Leu Glu Lys Glu Glu Glu Ser Glu Pro Glu Glu Lys Ser 
545                 550                 555                 560 


Glu Glu Glu Ile Glu Ile Ile Glu Gly Gln Glu Glu Ser Asn Gln Ser 
                565                 570                 575     


Asn Lys Ser Gly Ser Glu Asp Glu Met Lys Glu Ala Asp Glu Ser Thr 
            580                 585                 590         


Gly Ser Gly Asp Gly Pro Ile Lys Ser Val Arg Lys Arg Arg Val Arg 
        595                 600                 605             


Lys Asp 
    610 


<210>  207
<211>  3049
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (155)..(1147)

<400>  207
gggccccgcg gcccgccata taaacccgcg cgcccgccag gcgctgcggc cgtcccgggc       60

cgtgactcct cctttccccc gccccgcctc cgttcggaga gccggcgggc gggcgcctct      120

cggccaggaa gcgcctcttg gacgcgtgtg accg atg ccc aga ttg cac gac cac      175
                                      Met Pro Arg Leu His Asp His         
                                      1               5                   

ttc tgg agc tgc tcc tgt gcg cac agc gcg agg cgc cga ggc ccc ccg        223
Phe Trp Ser Cys Ser Cys Ala His Ser Ala Arg Arg Arg Gly Pro Pro           
        10                  15                  20                        

cga gcc agc gcc gcg ggg ctg gcg gcc aag gtt ggg gag atg atc aac        271
Arg Ala Ser Ala Ala Gly Leu Ala Ala Lys Val Gly Glu Met Ile Asn           
    25                  30                  35                            

gtt tcc gtg tcc ggg ccc tcc ctg ctg gcg gcc cac ggt gcc ccg gac        319
Val Ser Val Ser Gly Pro Ser Leu Leu Ala Ala His Gly Ala Pro Asp           
40                  45                  50                  55            

gct gac ccc gcg ccc agg ggc cgc agt gct gcg atg agc ggc ccc gag        367
Ala Asp Pro Ala Pro Arg Gly Arg Ser Ala Ala Met Ser Gly Pro Glu           
                60                  65                  70                

ccc ggc agc ccc tac ccc aac acc tgg cat cat cgc ctg ttg cag agg        415
Pro Gly Ser Pro Tyr Pro Asn Thr Trp His His Arg Leu Leu Gln Arg           
            75                  80                  85                    

agc ctc gtg ctc ttc tcg gtt ggg gtg gtc cta gcc ctg gtg ctc aac        463
Ser Leu Val Leu Phe Ser Val Gly Val Val Leu Ala Leu Val Leu Asn           
        90                  95                  100                       

ctg ctg cag atc cag agg aat gtc act ctc ttc ccc gag gag gtg atc        511
Leu Leu Gln Ile Gln Arg Asn Val Thr Leu Phe Pro Glu Glu Val Ile           
    105                 110                 115                           

gcc acc atc ttt tcc tcc gcc tgg tgg gtc cct ccc tgc tgc ggg aca        559
Ala Thr Ile Phe Ser Ser Ala Trp Trp Val Pro Pro Cys Cys Gly Thr           
120                 125                 130                 135           

gca gct gct gtt gtt ggc cta ctg tac ccc tgt atc gac agt cac ctc        607
Ala Ala Ala Val Val Gly Leu Leu Tyr Pro Cys Ile Asp Ser His Leu           
                140                 145                 150               

gga gaa ccc cac aaa ttt aag aga gaa tgg gcc agt gtc atg cgc tgc        655
Gly Glu Pro His Lys Phe Lys Arg Glu Trp Ala Ser Val Met Arg Cys           
            155                 160                 165                   

ata gca gtt ttt gtt ggc att aac cac gcc agt gct aaa ttg gat ttt        703
Ile Ala Val Phe Val Gly Ile Asn His Ala Ser Ala Lys Leu Asp Phe           
        170                 175                 180                       

gcc aat aat gtc cag ctg tcc ttg act tta gca gcc cta tct ttg ggc        751
Ala Asn Asn Val Gln Leu Ser Leu Thr Leu Ala Ala Leu Ser Leu Gly           
    185                 190                 195                           

ctt tgg tgg aca ttt gat cgt tcc aga agt ggc ctt ggg ctg ggg atc        799
Leu Trp Trp Thr Phe Asp Arg Ser Arg Ser Gly Leu Gly Leu Gly Ile           
200                 205                 210                 215           

acc ata gct ttt cta gct acg ctg atc acg cag ttt ctc gtg tat aat        847
Thr Ile Ala Phe Leu Ala Thr Leu Ile Thr Gln Phe Leu Val Tyr Asn           
                220                 225                 230               

ggt gtc tat cag tat aca tcc cca gat ttc ctc tat att cgt tct tgg        895
Gly Val Tyr Gln Tyr Thr Ser Pro Asp Phe Leu Tyr Ile Arg Ser Trp           
            235                 240                 245                   

ctc cct tgt ata ttt ttc tca gga ggc gtc acg gtg ggg aac ata gga        943
Leu Pro Cys Ile Phe Phe Ser Gly Gly Val Thr Val Gly Asn Ile Gly           
        250                 255                 260                       

cga cag tta gct atg ctg ata ccc ttc tgt gag gag ttg aat ttg aag        991
Arg Gln Leu Ala Met Leu Ile Pro Phe Cys Glu Glu Leu Asn Leu Lys           
    265                 270                 275                           

acc act tgg ctg ttt cac aaa acc aga agt aat tac agg gtg ttc ctg       1039
Thr Thr Trp Leu Phe His Lys Thr Arg Ser Asn Tyr Arg Val Phe Leu           
280                 285                 290                 295           

aaa agc ccc ata gtg att gag tct tca aaa cca ccg att ctg aga gca       1087
Lys Ser Pro Ile Val Ile Glu Ser Ser Lys Pro Pro Ile Leu Arg Ala           
                300                 305                 310               

agg aag att ttg gaa gaa aat ctg act gtg gat tat gac aaa gat tat       1135
Arg Lys Ile Leu Glu Glu Asn Leu Thr Val Asp Tyr Asp Lys Asp Tyr           
            315                 320                 325                   

ctt ttt tct taa gtaatctatt tagatcgggc tgactgtaca aatgactcct           1187
Leu Phe Ser                                                               
        330                                                               

ggaaaaaact cttcacctag tctagaatag ggaggtggag aatgatgact taccctgaag     1247

tcttcccttg actgcccgca ctggcgcctg tctgtgccct ggagcattct gcccaggcta     1307

cgtgggttca ggcaggtggc agcttcccaa gtattcgatt tcattcatgt gattaaaaca     1367

agttgccata tttcaaagcc ttgaactaag actcaattac caacccgcag ttttgtgtca     1427

gtgcccaaag gaggtaggtt gatggtgctt aacaaacatg aagtatggtg taataggaat     1487

aatatttatc caaaagattt ttaaaaatag ggctgtgttt aaaaaaaaaa aacaaaacaa     1547

gaaaagcagc agtgattata gagaggtcac actctaagtg gggtcgcggc gtggccacgc     1607

ttcacggtca cgctcgtccg tcctgcagtg gcgtgtttac atggtcacac gtgtgtgtat     1667

caccagtggg tcaactgctt gtcattcctc ccgtggcagt ttgtgtagac aatcttactg     1727

agcaaaaggc aatgaaaagt cttggttccc acactgcgat atattggaat tttcacctca     1787

gtttatgaag tttatttcga aatccatagt catctaagaa tgaatacctg tctgccatgt     1847

atttcaatct tagtgagcca aaattgtttg tttgttacta cagaatagag atgactgttt     1907

tttgccacag ccctatggaa tttgcaatct gtgattgcct tgtaaaaagg agagtgcata     1967

tggcactgca ttaaacgtgt ggtgtttcta gtcaatgata ttggtgagca caatgtattc     2027

atttaatggc atagaccata ccagacctaa tttgcaagta ttgggtctta aacttcaagt     2087

gcaatgtata tgaaaaccaa tctgagcctt gtatctctta aatatttatt ttttttaacg     2147

tgtgagatgt tcgagagaag gttctccatt catttcagtg ctgcctggag gaaactcggc     2207

aatgatttct ttcagttgtg aagttccttt cgtgttacac cctccactga accctcaacc     2267

ttcgaaatac tccagttttg tgggtttggt catttttact tataaattta cctttttgta     2327

ttttgcaatt tacatgtgtt tggtttgttt taaattctgt gaaagtggct tgattaaaag     2387

actcctttta aatggaagcc accagtcagc agaatggaag cttagaggaa cttgcctgtg     2447

agcgctggtc tttgtgtttg gttttgtgat gtaacgatct ttgctggggt tttttgcttt     2507

gttttgaggg aaatgtcttg gagtaaattt taagttcctg gagttaattt gttttacagg     2567

aattttgttt tttaaaaaaa taggatcatt ctgaactttg gaatgacccc cttatatatt     2627

ttctgaaaat gaaaacagtt acatgaaaaa aatttccaat gaagatgtca gcattttatg     2687

aaaaaccaga agttattaga tgaaagcagc gagtgaatct ttaaaacaga cttgatcacg     2747

cacacacaat aagtctttct ctccgaaacc ggaagtaaat ctatatctgt tagaaataat     2807

gtagccaaaa gaatgtaaat ttgaggattt ttttgccaat agtttataga aaatatatga     2867

accaaagtga tttgagtttg taaaaatgta aaatagtatg aacaaaattt gcactctacc     2927

agatttgaac atctagtgag gttcacattc atactaagtt ttcaacattg tgttcttttt     2987

gcattcattt tttactttta ttaaaggttc aaaaccaaaa aaaaaaaaaa aaaaaaaaaa     3047

aa                                                                    3049


<210>  208
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Pro Arg Leu His Asp His Phe Trp Ser Cys Ser Cys Ala His Ser 
1               5                   10                  15      


Ala Arg Arg Arg Gly Pro Pro Arg Ala Ser Ala Ala Gly Leu Ala Ala 
            20                  25                  30          


Lys Val Gly Glu Met Ile Asn Val Ser Val Ser Gly Pro Ser Leu Leu 
        35                  40                  45              


Ala Ala His Gly Ala Pro Asp Ala Asp Pro Ala Pro Arg Gly Arg Ser 
    50                  55                  60                  


Ala Ala Met Ser Gly Pro Glu Pro Gly Ser Pro Tyr Pro Asn Thr Trp 
65                  70                  75                  80  


His His Arg Leu Leu Gln Arg Ser Leu Val Leu Phe Ser Val Gly Val 
                85                  90                  95      


Val Leu Ala Leu Val Leu Asn Leu Leu Gln Ile Gln Arg Asn Val Thr 
            100                 105                 110         


Leu Phe Pro Glu Glu Val Ile Ala Thr Ile Phe Ser Ser Ala Trp Trp 
        115                 120                 125             


Val Pro Pro Cys Cys Gly Thr Ala Ala Ala Val Val Gly Leu Leu Tyr 
    130                 135                 140                 


Pro Cys Ile Asp Ser His Leu Gly Glu Pro His Lys Phe Lys Arg Glu 
145                 150                 155                 160 


Trp Ala Ser Val Met Arg Cys Ile Ala Val Phe Val Gly Ile Asn His 
                165                 170                 175     


Ala Ser Ala Lys Leu Asp Phe Ala Asn Asn Val Gln Leu Ser Leu Thr 
            180                 185                 190         


Leu Ala Ala Leu Ser Leu Gly Leu Trp Trp Thr Phe Asp Arg Ser Arg 
        195                 200                 205             


Ser Gly Leu Gly Leu Gly Ile Thr Ile Ala Phe Leu Ala Thr Leu Ile 
    210                 215                 220                 


Thr Gln Phe Leu Val Tyr Asn Gly Val Tyr Gln Tyr Thr Ser Pro Asp 
225                 230                 235                 240 


Phe Leu Tyr Ile Arg Ser Trp Leu Pro Cys Ile Phe Phe Ser Gly Gly 
                245                 250                 255     


Val Thr Val Gly Asn Ile Gly Arg Gln Leu Ala Met Leu Ile Pro Phe 
            260                 265                 270         


Cys Glu Glu Leu Asn Leu Lys Thr Thr Trp Leu Phe His Lys Thr Arg 
        275                 280                 285             


Ser Asn Tyr Arg Val Phe Leu Lys Ser Pro Ile Val Ile Glu Ser Ser 
    290                 295                 300                 


Lys Pro Pro Ile Leu Arg Ala Arg Lys Ile Leu Glu Glu Asn Leu Thr 
305                 310                 315                 320 


Val Asp Tyr Asp Lys Asp Tyr Leu Phe Ser 
                325                 330 


<210>  209
<211>  2344
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (381)..(1856)

<400>  209
cgcgggccac cccgctctcc tcgccgccgc ggcggcaggc gcggggccgc gccgcgaggc       60

ctgatccctg cagcgcgggc aggcggcgtc gcagagcgga gctagctgga tgcgtccgga      120

ctcctgcagg tgagagtgat tttccagtga ttgctttggc ctgtacaacc agagaacagg      180

attcttccct tctttttggc caccaaatgc ctatgtgcac cacacattcc agtgtgctga      240

gaagggcaga gcttcttgga tgatgatgga cgtcccaccg ggcaggatga aggcagagcg      300

tgtggcatct ccacctcaag ggtgcagcct gatcttcctc ttctcccttg ccagccagca      360

ctctgccttc tgtatccacc atg gtg ttt ggt gag ttt ttc cat cgc cct gga      413
                      Met Val Phe Gly Glu Phe Phe His Arg Pro Gly         
                      1               5                   10              

caa gac gag gaa ctt gtc aac ctg aat gtg ggg ggc ttt aag cag tct        461
Gln Asp Glu Glu Leu Val Asn Leu Asn Val Gly Gly Phe Lys Gln Ser           
            15                  20                  25                    

gtt gac caa agc acc ctc ctg cgg ttt cct cac acc aga ctg ggg aag        509
Val Asp Gln Ser Thr Leu Leu Arg Phe Pro His Thr Arg Leu Gly Lys           
        30                  35                  40                        

ctg ctt act tgc cat tct gaa gag gcc att ctg gag ctg tgt gat gat        557
Leu Leu Thr Cys His Ser Glu Glu Ala Ile Leu Glu Leu Cys Asp Asp           
    45                  50                  55                            

tac agt gtg gcc gat aag gaa tac tac ttt gat cgg aat ccc tcc ttg        605
Tyr Ser Val Ala Asp Lys Glu Tyr Tyr Phe Asp Arg Asn Pro Ser Leu           
60                  65                  70                  75            

ttc aga tat gtt ttg aat ttt tat tac acg ggg aag ctg cat gtc atg        653
Phe Arg Tyr Val Leu Asn Phe Tyr Tyr Thr Gly Lys Leu His Val Met           
                80                  85                  90                

gag gag ctg tgc gta ttc tca ttc tgc cag gag atc gag tac tgg ggc        701
Glu Glu Leu Cys Val Phe Ser Phe Cys Gln Glu Ile Glu Tyr Trp Gly           
            95                  100                 105                   

atc aac gag ctc ttc att gat tct tgc tgc agc aat cgc tac cag gaa        749
Ile Asn Glu Leu Phe Ile Asp Ser Cys Cys Ser Asn Arg Tyr Gln Glu           
        110                 115                 120                       

cgc aag gag gaa aac cac gag aag gac tgg gac cag aaa agc cat gat        797
Arg Lys Glu Glu Asn His Glu Lys Asp Trp Asp Gln Lys Ser His Asp           
    125                 130                 135                           

gtg agt acc gac tcc tcg ttt gaa gag tcg tct ctg ttt gag aaa gag        845
Val Ser Thr Asp Ser Ser Phe Glu Glu Ser Ser Leu Phe Glu Lys Glu           
140                 145                 150                 155           

ctg gag aag ttt gac aca ctg cga ttt ggt cag ctc cgg aag aaa atc        893
Leu Glu Lys Phe Asp Thr Leu Arg Phe Gly Gln Leu Arg Lys Lys Ile           
                160                 165                 170               

tgg att aga atg gag aat cca gcg tac tgc ctg tcc gct aag ctt atc        941
Trp Ile Arg Met Glu Asn Pro Ala Tyr Cys Leu Ser Ala Lys Leu Ile           
            175                 180                 185                   

gct atc tcc tcc ttg agc gtg gtg ctg gcc tcc atc gtg gcc atg tgc        989
Ala Ile Ser Ser Leu Ser Val Val Leu Ala Ser Ile Val Ala Met Cys           
        190                 195                 200                       

gtt cac agc atg tcg gag ttc cag aat gag gat gga gaa gtg gat gat       1037
Val His Ser Met Ser Glu Phe Gln Asn Glu Asp Gly Glu Val Asp Asp           
    205                 210                 215                           

ccg gtg ctg gaa gga gtg gag atc gcg tgc att gcc tgg ttc acc ggg       1085
Pro Val Leu Glu Gly Val Glu Ile Ala Cys Ile Ala Trp Phe Thr Gly           
220                 225                 230                 235           

gag ctt gcc gtc cgg ctg gct gcc gct cct tgt caa aag aaa ttc tgg       1133
Glu Leu Ala Val Arg Leu Ala Ala Ala Pro Cys Gln Lys Lys Phe Trp           
                240                 245                 250               

aaa aac cct ctg aac atc att gac ttt gtc tct att att ccc ttc tat       1181
Lys Asn Pro Leu Asn Ile Ile Asp Phe Val Ser Ile Ile Pro Phe Tyr           
            255                 260                 265                   

gcc acg ttg gct gta gac acc aag gag gaa gag agt gag gat att gag       1229
Ala Thr Leu Ala Val Asp Thr Lys Glu Glu Glu Ser Glu Asp Ile Glu           
        270                 275                 280                       

aac atg ggc aag gtg gtc cag atc cta cgg ctt atg agg att ttc cga       1277
Asn Met Gly Lys Val Val Gln Ile Leu Arg Leu Met Arg Ile Phe Arg           
    285                 290                 295                           

att cta aag ctt gcc cgg cac tcg gta gga ctt cgg tct cta ggt gcc       1325
Ile Leu Lys Leu Ala Arg His Ser Val Gly Leu Arg Ser Leu Gly Ala           
300                 305                 310                 315           

aca ctg aga cac agc tac cat gaa gtt ggg ctt ctg ctt ctc ttc ctc       1373
Thr Leu Arg His Ser Tyr His Glu Val Gly Leu Leu Leu Leu Phe Leu           
                320                 325                 330               

tct gtg ggc att tcc att ttc tct gtg ctt atc tac tcc gtg gag aaa       1421
Ser Val Gly Ile Ser Ile Phe Ser Val Leu Ile Tyr Ser Val Glu Lys           
            335                 340                 345                   

gat gac cac aca tcc agc ctc acc agc atc ccc atc tgc tgg tgg tgg       1469
Asp Asp His Thr Ser Ser Leu Thr Ser Ile Pro Ile Cys Trp Trp Trp           
        350                 355                 360                       

gcc acc atc agc atg aca act gtg ggc tat gga gac acc cac ccg gtc       1517
Ala Thr Ile Ser Met Thr Thr Val Gly Tyr Gly Asp Thr His Pro Val           
    365                 370                 375                           

acc ttg gcg gga aag ctc atc gcc agc aca tgc atc atc tgt ggc atc       1565
Thr Leu Ala Gly Lys Leu Ile Ala Ser Thr Cys Ile Ile Cys Gly Ile           
380                 385                 390                 395           

ttg gtg gtg gcc ctt ccc atc acc atc atc ttc aac aag ttt tcc aag       1613
Leu Val Val Ala Leu Pro Ile Thr Ile Ile Phe Asn Lys Phe Ser Lys           
                400                 405                 410               

tac tac cag aag caa aag gac att gat gtg gac cag tgc agt gag gat       1661
Tyr Tyr Gln Lys Gln Lys Asp Ile Asp Val Asp Gln Cys Ser Glu Asp           
            415                 420                 425                   

gca cca gag aag tgt cat gag cta cct tac ttt aac att agg gat ata       1709
Ala Pro Glu Lys Cys His Glu Leu Pro Tyr Phe Asn Ile Arg Asp Ile           
        430                 435                 440                       

tat gca cag cgg atg cac acc ttc att acc agt ctc tct tct gta ggc       1757
Tyr Ala Gln Arg Met His Thr Phe Ile Thr Ser Leu Ser Ser Val Gly           
    445                 450                 455                           

att gtg gtg agc gat cct gac tcc aca gat gct tca agc att gaa gac       1805
Ile Val Val Ser Asp Pro Asp Ser Thr Asp Ala Ser Ser Ile Glu Asp           
460                 465                 470                 475           

aat gag gac att tgt aac acc acc tcc ttg gag aat tgc aca gca aaa       1853
Asn Glu Asp Ile Cys Asn Thr Thr Ser Leu Glu Asn Cys Thr Ala Lys           
                480                 485                 490               

tga gcgggggtgt ttgtgcctgt ttctcttatc ctttcccgac attaggttaa            1906

cacagcttta taaacctcag tgggttcgtt aaaatcattt aattctcagg gtgtaccttt     1966

cagccatagt tggacattca ttgctgaatt ctgaaatgat agaattgtct ttatttttct     2026

ctgtgaggtc aattaaatgc cttgttctga aatttatttt ttacaagaga gagttgtgat     2086

atagtttgga atataagata aatggtattg ggtggggttt gtggctacag cttatgcatc     2146

attctgtgtt tgtcatttac tcacattgag ctaactttaa attactgaca agtagaatca     2206

aaggtgcagc tgactgagac gacatgcatg taagatccac aaaatgagac aatgcatgta     2266

aatccatgct catgttctaa acatggaaac taggagccta ataaacttcc taattcagta     2326

tggaaaaaaa aaaaaaaa                                                   2344


<210>  210
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Val Phe Gly Glu Phe Phe His Arg Pro Gly Gln Asp Glu Glu Leu 
1               5                   10                  15      


Val Asn Leu Asn Val Gly Gly Phe Lys Gln Ser Val Asp Gln Ser Thr 
            20                  25                  30          


Leu Leu Arg Phe Pro His Thr Arg Leu Gly Lys Leu Leu Thr Cys His 
        35                  40                  45              


Ser Glu Glu Ala Ile Leu Glu Leu Cys Asp Asp Tyr Ser Val Ala Asp 
    50                  55                  60                  


Lys Glu Tyr Tyr Phe Asp Arg Asn Pro Ser Leu Phe Arg Tyr Val Leu 
65                  70                  75                  80  


Asn Phe Tyr Tyr Thr Gly Lys Leu His Val Met Glu Glu Leu Cys Val 
                85                  90                  95      


Phe Ser Phe Cys Gln Glu Ile Glu Tyr Trp Gly Ile Asn Glu Leu Phe 
            100                 105                 110         


Ile Asp Ser Cys Cys Ser Asn Arg Tyr Gln Glu Arg Lys Glu Glu Asn 
        115                 120                 125             


His Glu Lys Asp Trp Asp Gln Lys Ser His Asp Val Ser Thr Asp Ser 
    130                 135                 140                 


Ser Phe Glu Glu Ser Ser Leu Phe Glu Lys Glu Leu Glu Lys Phe Asp 
145                 150                 155                 160 


Thr Leu Arg Phe Gly Gln Leu Arg Lys Lys Ile Trp Ile Arg Met Glu 
                165                 170                 175     


Asn Pro Ala Tyr Cys Leu Ser Ala Lys Leu Ile Ala Ile Ser Ser Leu 
            180                 185                 190         


Ser Val Val Leu Ala Ser Ile Val Ala Met Cys Val His Ser Met Ser 
        195                 200                 205             


Glu Phe Gln Asn Glu Asp Gly Glu Val Asp Asp Pro Val Leu Glu Gly 
    210                 215                 220                 


Val Glu Ile Ala Cys Ile Ala Trp Phe Thr Gly Glu Leu Ala Val Arg 
225                 230                 235                 240 


Leu Ala Ala Ala Pro Cys Gln Lys Lys Phe Trp Lys Asn Pro Leu Asn 
                245                 250                 255     


Ile Ile Asp Phe Val Ser Ile Ile Pro Phe Tyr Ala Thr Leu Ala Val 
            260                 265                 270         


Asp Thr Lys Glu Glu Glu Ser Glu Asp Ile Glu Asn Met Gly Lys Val 
        275                 280                 285             


Val Gln Ile Leu Arg Leu Met Arg Ile Phe Arg Ile Leu Lys Leu Ala 
    290                 295                 300                 


Arg His Ser Val Gly Leu Arg Ser Leu Gly Ala Thr Leu Arg His Ser 
305                 310                 315                 320 


Tyr His Glu Val Gly Leu Leu Leu Leu Phe Leu Ser Val Gly Ile Ser 
                325                 330                 335     


Ile Phe Ser Val Leu Ile Tyr Ser Val Glu Lys Asp Asp His Thr Ser 
            340                 345                 350         


Ser Leu Thr Ser Ile Pro Ile Cys Trp Trp Trp Ala Thr Ile Ser Met 
        355                 360                 365             


Thr Thr Val Gly Tyr Gly Asp Thr His Pro Val Thr Leu Ala Gly Lys 
    370                 375                 380                 


Leu Ile Ala Ser Thr Cys Ile Ile Cys Gly Ile Leu Val Val Ala Leu 
385                 390                 395                 400 


Pro Ile Thr Ile Ile Phe Asn Lys Phe Ser Lys Tyr Tyr Gln Lys Gln 
                405                 410                 415     


Lys Asp Ile Asp Val Asp Gln Cys Ser Glu Asp Ala Pro Glu Lys Cys 
            420                 425                 430         


His Glu Leu Pro Tyr Phe Asn Ile Arg Asp Ile Tyr Ala Gln Arg Met 
        435                 440                 445             


His Thr Phe Ile Thr Ser Leu Ser Ser Val Gly Ile Val Val Ser Asp 
    450                 455                 460                 


Pro Asp Ser Thr Asp Ala Ser Ser Ile Glu Asp Asn Glu Asp Ile Cys 
465                 470                 475                 480 


Asn Thr Thr Ser Leu Glu Asn Cys Thr Ala Lys 
                485                 490     


<210>  211
<211>  7531
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (298)..(660)

<400>  211
gaccagcttc cccaactccc tctggctccc gccttcgccc gcttccggtc gtcgtcgtcg       60

ccgctgctgc cgctgctgtt gctcctgagg ctgctggctg aggccggagg atcgagcggc      120

ggcggcggcg gcggctgaga gggcggcggc gggagcggag cgggacgagg gaacgggagg      180

aagcgagcga ggagcgcgca gagcgcgctt ttccgtccgc ctgaggagcc gaagcagccc      240

cggccccgcc gccgccgcct gcccgccgga caaagccgag agcccgcgcc cacagcc         297

atg tcc tcg tca gcc ggc agc ggc cac cag ccc agc cag agc cgc gcc        345
Met Ser Ser Ser Ala Gly Ser Gly His Gln Pro Ser Gln Ser Arg Ala           
1               5                   10                  15                

atc ccc acc cgc acc gtg gcc atc agc gac gcc gcg cag cta cct cat        393
Ile Pro Thr Arg Thr Val Ala Ile Ser Asp Ala Ala Gln Leu Pro His           
            20                  25                  30                    

gac tat tgc acc acg ccc ggg ggg acg ctc ttc tcc acc aca ccg gga        441
Asp Tyr Cys Thr Thr Pro Gly Gly Thr Leu Phe Ser Thr Thr Pro Gly           
        35                  40                  45                        

gga act cga atc att tat gac aga aag ttt ctg ttg gat cgt cgc aat        489
Gly Thr Arg Ile Ile Tyr Asp Arg Lys Phe Leu Leu Asp Arg Arg Asn           
    50                  55                  60                            

tct ccc atg gct cag acc cca ccc tgc cac ctg ccc aat atc cca gga        537
Ser Pro Met Ala Gln Thr Pro Pro Cys His Leu Pro Asn Ile Pro Gly           
65                  70                  75                  80            

gtc act agc cct ggc acc tta att gaa gac tcc aaa gta gaa gta aac        585
Val Thr Ser Pro Gly Thr Leu Ile Glu Asp Ser Lys Val Glu Val Asn           
                85                  90                  95                

aat ttg aac aac ttg aac aat cac gac agg aaa cat gca gtt ggg gat        633
Asn Leu Asn Asn Leu Asn Asn His Asp Arg Lys His Ala Val Gly Asp           
            100                 105                 110                   

gat gct cag ttc gag atg gac atc tga ctctcctgca aggattagaa              680
Asp Ala Gln Phe Glu Met Asp Ile                                           
        115                 120                                           

gaaaagcagc aacactgata cttgtgtgca cctgatttgg ccaataggat caacagtgaa      740

aagacagaag aggcaatacc agcagtcccc attacagtct ccacctcccc gtcttcctct      800

gggtgccaaa tgatgggaag atgagcttca tctgaccatt tcttctccct gtctcctgtt      860

ccccttccca gttaaacagg ttagattgaa ggcccttgct gtatttctgt agagctaagc      920

agcccttaga ggaaaacagt tcaactctga ctttcctagt tgttttttta ttgagagcca      980

ccctcatacc ctgtaatttt gtcccaaatc aaatatcaac ctaccaacaa ctgcctggct     1040

gggaagtctg gggaagggat acagagcttg gtgggcctaa caccattcat attccttacc     1100

ctctgtctct cctccctgta tcccacctat ggttcagtgt tgcaagagtc tgggcttggg     1160

gtctttaaaa ccagcagggg gaaatgataa aaagagagct gctttccctt ttaccttgag     1220

gtattcgtcc ctcgggacag agcacagctt gtgcaactct ggtagcgtta ccctgtgaca     1280

ctgttttgag gtccacttcc tttctttcct ctgggaggaa tgtcttctgt ctttggtatt     1340

atagttcatc ttcccattct tttacttagt gcatttgtgc agatattttt aactctgtac     1400

atcagaagag agcccttggt aaccagtttt gctcttcttc tgccactcct ccctgcttgc     1460

atctcgttgc tggcagagtc ctcttgtact tcaagaaagc aaagtgattt tgtctgctcc     1520

tagagcaggt ccataccaag taatagaggc actttagctt ccacttggtg ggtaaggcct     1580

gatcatagta ttctgtcaga taatgcctaa gaatgaccgc tgaagaacgt tgacccattt     1640

gagtacccgg tctcagtcgt catttttaag tccagtgagc attgtggtag ttgttcttag     1700

attgcagttt cttatgtttt gagtttgaag ttgattttca gaatgttctt agaaaagaac     1760

tgcatttttt tcctttgtgg atctgctttg tttggctgct gggatagata agcatgggct     1820

taaaaaatgt gttcctccca gttttcttgc ctttcctgtt gtactctgaa tttctctccc     1880

tacctccctc actttcttcc tctctccttc ctttccttcc tttttctcta ccaggccatt     1940

tttcaaattt acatcaaaga tacctgaagt gttggtatct gagaatatct gtcactcctc     2000

ttatctgaga agtgaccttt tatttttaag atgactacag acctattttt agatatgttt     2060

tcagtacaat tttgaacagc aactttttaa ttaaacatct tccagtgtta ggaagttgag     2120

aaacgttcat aggcaagtct gctgttctat gtcaccatct tttgtctccc ctagtccccc     2180

aggagctctt tcctttcccc tctagttttg ggtgtgcatg tttggagttt gtagtgggtg     2240

gtttgtaaaa ctggaccatt ctgccttgct atgggttgtt caagaaagcc tcattctttt     2300

ctgtgaccct ttcgcttttg cattcaccct ccttcccacc tacctgtcct ggggctgttg     2360

agcagcataa taatcccggg agaatgattc ccctcataga aagacaaaag catccatccc     2420

ctcatagtta agtagccact ggtgtcctgg gaatttctgg ttggatttgg tgccctgaac     2480

ttttttatta agaaatcaga tcccagggtg agagtaacag gccatttggc caagaaagaa     2540

acctgtttgt ttttcttttg aactatgaaa agaccctgtt tgtgaatata ttttagaaag     2600

agaggaagga tgtctgcaga actttgttct gttttctgcc acaaaaatgt gaatagttca     2660

gagtgaaaac cttttgtgat ggttgatgtc tcaggaataa gctggatctc caatgttttg     2720

gggatgcttt gagtctcaaa aaaaattgat aatcagaaaa gtaatttttg tttgtttgtt     2780

taatgtatcc ctgttctgtt tttaattaaa ctccaagtct cattttacat attcttggaa     2840

aaacctaagt tgctctgtaa tttacataag aagcatgctc aggacctctt tgtaccccgg     2900

ggagcctgat tctttgggaa tgaagctttt cattcttcat acactggcct tggcatcctg     2960

tggaatttga cccaactagc agctagtcag tctgtcagtg agcagaagag tgaactcttc     3020

ttgatcttta ttgctatgtg tgaaaacttg gcttcctcac tgaacggtga ggaatggatt     3080

taaagcatga gctttagtag tatcaagatg ccattttcct ttttcttgct gtcttgggga     3140

gcttctgcat gtgaccccct aatcagaagg catgttttta gtatttcttg ggagtgtcag     3200

ctgtataatg cagcagctgt tcaatccctt acccttctct gcaaggactt ccttacagct     3260

tggtgcagtt ctttcccaga ggccaccact actagacagt ctttctttta tcttatggag     3320

ataaattggc atttaaaaaa taatttcaca aggcatgaga taaactttca atagatgata     3380

cctttgtgtc atgcctcatg gaattatttt tagaacaagc cagagtccat tgagtggttt     3440

acctctgcat gtttggaggg aacctcacag atgaaaccct taatgaataa tgtgtccggg     3500

gttttttaga gagaaggagc actcttaagt taccactttg agacagctct taacatctta     3560

gtgaccattt gtagttttct ttttatgagg aacccatgct tctatacttg ggcggacaat     3620

cgagcttaat gagaagtgac ttcccttcaa attccaacag cagacatgca ttgtcatgat     3680

tctgtcttct ttttagtgtg gtttattgag ttcagcagtt ctcatattct gtttaaatag     3740

gtacagcatt ttcaagggca cagatacaga gaagctggct ttctaggtat tgggcttcca     3800

agccaagagt tttgtccttc cacctgtatt agttatctat tgctgtgtaa aaaattaccc     3860

taaatttagt atgttaaaat agtaaacatt atctgtcagt ttctgtgggt taagaatttg     3920

ggagtagttt aacatgatgg ttctggccca tggtatcatg aagttacagt caagattgaa     3980

caggggctgc agtcagctgg agctggagaa accacttcca agttctctct ttgtggccgt     4040

tggcaggatg cctcagtttc ttcccatgtg ggtctctgcg tagggcagca tgagtgtcct     4100

cacaccatga cacctggctt ctccctgagc agctgattcc agagatcatg gggcagggcc     4160

aggagaaagc tgcagtgcct tttaagacat agtcttggaa aggacacacc gtcacttctt     4220

atcctagttg ttagaagcaa gccactaagt tcagcctgca ctcaaggaga gaggaattac     4280

acatacctct accccaatgg agcagtagca aagaatttat ggacatatct taaaagcacc     4340

acaccccaac tggggatgaa agtaggtcaa cagggaggta ggtttaatct agataagctg     4400

aaagatagat tgctatcaaa aacagttctc caagatgtgc atagccaaac tgggatagaa     4460

ggcaaactcc ccaaagctac ctgctggttt tgagaggggt ggtaagacat ggcaattccc     4520

aggagtagta gaaaataata tgcctgacta ccaacagctc aagtatgctt atttgcacat     4580

cctagacttg gtgtctgtaa gactcagtta ccacttttat tttcctgtag ctaggagtta     4640

gcaaaaggaa ctggggcctt ccagccgagc cactaaacct gtcttatttg gaatggggat     4700

tgtccagcaa agggagcaaa catgaattag atgttaagct attgagctga agaaaagaaa     4760

gcagttcaca tttaggtgaa atagatgatg ttatcaggaa gccaggttcc caccagagtc     4820

ggtgcttggt acctggtctc tccagtctca acagactcag gtcaggtctc tcacccagga     4880

agcaaccact caataaaata gagaacatct gagaattaca aatgtctatg cttgattgct     4940

cctctaaatc cagtgcatag gttaaccctg catgcccatt tcttcctggg cttcttgatg     5000

gcaatgtgtt cttaaataac tggtcttgtg ttcatgctaa agacaaactt acatgaagtt     5060

tttcagttta agacattcta gtgaatggct gctatgtgtt tctggcactc attcctaacc     5120

aagtctttag agatttcaga tgaccttaaa gatgcaatat ctttttcttt ctttctttct     5180

ttcttttttt ctgagacaag agttgcgccc tgtcgcccag gctggggtgc tggagtgcag     5240

tggtgcgatc tcagctcact gcagcctctg cttcccaggt tcaagtgttt ctcctgcctc     5300

agccttccga gtagctggga ttacaggcat gtaccactat gcctggctaa tttttatttc     5360

tatattttta gtagagatgg ggtttcatca tgtttgccag gctggtctcg aactcctggc     5420

ctcaagtgat ccgcccacct cagcctccca aagtgctggg attacaggcg cgagccaccg     5480

cgcctggcca aagatgcaaa ttcttgtttg gatttatgct ctgcctcttc ccagcatttt     5540

cttatctgta gccctgcttg cttgagagta tacttggata agaagtattg ctgttgaggg     5600

agctataaga aaaggattct tcttccagaa gtaaagaact catctttaga gtacctttaa     5660

atgaattttg tttttctttc ttattttgag gtggattggt cttctctttt tttgggtttc     5720

cagctcactg ggactctcag accttacctt tccagctcaa acaccattag ttaaattcct     5780

tcattctcat tagaatgcag cctgctgagt atgtgggttt cactgccgga gtccatcatt     5840

tagccagtat acatagagga actgcttcga atcaaggcaa ctggtgaagg gcttagcatg     5900

ttggcagcaa tatcccagag attgaatctg tttgcatttt cctcatctag gataacagct     5960

gcttgaagcc agggctctta gccctttgca ttccccttga gcgaggaagc cacactgcct     6020

ttctgtgtct ggttcagagc tcttccttct tggcatgttt tctggactac atgcacatgg     6080

gcagctatag attaatctgc aaaacctagt cacttaccta cccataatat ctgggaaggt     6140

gtggtatttg ttttaaagaa acattgtttc tttgggaggg cagtttctgt ctggactttg     6200

aggtggactt agttatccct acagttcttt aactctcagc ttttaataaa agatgaaatc     6260

agatattgat gcagttgggt cacaattctt tagaatgctt ctaccccagg gccgcttcct     6320

gttcctagtc atggttttcc agtttagtag tggagtttct tgaggctaac ttacagaaat     6380

ttctaactga aaactttaag agttattgat acttgttttt tcagtcagtc acttacatca     6440

cctagcctac tctctggaat ttaaatttat ttctctaggc tggtcctgga agttgataac     6500

cttttggcaa agcttagatt taggagaagg cttgagtccc tgttcagcgg gtctgtggat     6560

tctctttgct tatggctctc tgcctgcagc cctggcagac catactgtat gtcatggata     6620

cccagtggaa atattactga gatgaaacac atttccaagg gtatttaaac tctcactctg     6680

ccacctttct aagggtggga ggctggcaga gatgctgcaa tgcttgataa tcatttggcc     6740

acactgaaat ttccaaaggg agctcttgcc ggtgcttaaa accaaaactc ctggacactt     6800

agaaaattcc atgaatctag cacaaaatat ccattcttgc ccaagtgtat cccctttctc     6860

tccagcttaa tctttttttt tttttttttt ttaaagccca ggccaagggt acttttaact     6920

ggaaactggg gaggagggaa gaacactagc agggagctaa gaggcaggtt gctgggtaag     6980

ccatcctgct cctacctggt gcctgtatct acattgctga gtgctgtgcg ccagtgcctt     7040

tccttcatct gcagatggag cccatctctt tccacctggg tgaggagacc ctctgctact     7100

ccaggggtaa accttaaaga aggtgtcttg aagagcccag aggacactca cgtgctaagg     7160

tgtccatttt atgcatcttt aaaatatttt atttaaaaaa aaaaatagcc ctgccctgtc     7220

ttagtgccac taacggccca gttccatcca ttctgaatgg aaaagcggag actgccagca     7280

ctttccttgg tcttcccttt gtctcccatg atgtgttgtt ccctcatccc tcccatccat     7340

ttcactgtgt gtggatggat agcagagggt accacgcagt ccttgaggca gtcctgtgtg     7400

attccatgat cagttgtttt tgtattttaa ctattcttcc aaaccagcag atgtttggaa     7460

attaaggaaa aaattaaatt ctcatcaatg gttgctgtta tagttaaatc agtaaagatc     7520

ttgagtatca a                                                          7531


<210>  212
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Ser Ser Ser Ala Gly Ser Gly His Gln Pro Ser Gln Ser Arg Ala 
1               5                   10                  15      


Ile Pro Thr Arg Thr Val Ala Ile Ser Asp Ala Ala Gln Leu Pro His 
            20                  25                  30          


Asp Tyr Cys Thr Thr Pro Gly Gly Thr Leu Phe Ser Thr Thr Pro Gly 
        35                  40                  45              


Gly Thr Arg Ile Ile Tyr Asp Arg Lys Phe Leu Leu Asp Arg Arg Asn 
    50                  55                  60                  


Ser Pro Met Ala Gln Thr Pro Pro Cys His Leu Pro Asn Ile Pro Gly 
65                  70                  75                  80  


Val Thr Ser Pro Gly Thr Leu Ile Glu Asp Ser Lys Val Glu Val Asn 
                85                  90                  95      


Asn Leu Asn Asn Leu Asn Asn His Asp Arg Lys His Ala Val Gly Asp 
            100                 105                 110         


Asp Ala Gln Phe Glu Met Asp Ile 
        115                 120 


<210>  213
<211>  1383
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(972)

<400>  213
atg tcg gcc gcc gtg gcg tgc ctg gac tac ttc gcc gcc gag tgc ctg         48
Met Ser Ala Ala Val Ala Cys Leu Asp Tyr Phe Ala Ala Glu Cys Leu           
1               5                   10                  15                

gtg tcc atg tcc gcg ggc gcc gtg gtt cac cgc cgc ccg ccg gac ccc         96
Val Ser Met Ser Ala Gly Ala Val Val His Arg Arg Pro Pro Asp Pro           
            20                  25                  30                    

gag ggc gcg ggt gga gcc gca ggc tcg gag gtg ggt gcg gcg cat ccg        144
Glu Gly Ala Gly Gly Ala Ala Gly Ser Glu Val Gly Ala Ala His Pro           
        35                  40                  45                        

gag tcc gct ctg ccg ggt ccg ggg cca tcg ggg ccc gcg tcg gtc ccc        192
Glu Ser Ala Leu Pro Gly Pro Gly Pro Ser Gly Pro Ala Ser Val Pro           
    50                  55                  60                            

cag ctc ccg cag gtc ccc gcc ccc agc ccc ggc gcg ggc ggc gcc gcg        240
Gln Leu Pro Gln Val Pro Ala Pro Ser Pro Gly Ala Gly Gly Ala Ala           
65                  70                  75                  80            

ccc cac ctg ctg gct gca agc gtc tgg gcg gac ttg cgc ggc agc tct        288
Pro His Leu Leu Ala Ala Ser Val Trp Ala Asp Leu Arg Gly Ser Ser           
                85                  90                  95                

ggc gag ggc tcc tgg gag aac tcg ggg gaa gct cca cgc gcc tcg tcc        336
Gly Glu Gly Ser Trp Glu Asn Ser Gly Glu Ala Pro Arg Ala Ser Ser           
            100                 105                 110                   

ggc ttc tcc gac ccg atc ccg tgc tcc gtc cag acc ccg tgc tcc gag        384
Gly Phe Ser Asp Pro Ile Pro Cys Ser Val Gln Thr Pro Cys Ser Glu           
        115                 120                 125                       

ctg gct ccc gcc tcc ggc gcc gcg gcg gtc tgc gct ccc gag agc tcc        432
Leu Ala Pro Ala Ser Gly Ala Ala Ala Val Cys Ala Pro Glu Ser Ser           
    130                 135                 140                           

tcc gat gcg ccc gcc gtc cca agc gcg cct gct gcc ccg ggc gca cca        480
Ser Asp Ala Pro Ala Val Pro Ser Ala Pro Ala Ala Pro Gly Ala Pro           
145                 150                 155                 160           

gca gcc tct ggt ggg ttc tct gga ggg gcc cta ggg gca ggc ccc gcc        528
Ala Ala Ser Gly Gly Phe Ser Gly Gly Ala Leu Gly Ala Gly Pro Ala           
                165                 170                 175               

ccc gcc gcg gat cag gcg ccc cgg agg agg tct gtc aca cct gct gcc        576
Pro Ala Ala Asp Gln Ala Pro Arg Arg Arg Ser Val Thr Pro Ala Ala           
            180                 185                 190                   

aag cgc cac caa tgc ccc ttc ccg ggc tgc acc aaa gcc tat tac aag        624
Lys Arg His Gln Cys Pro Phe Pro Gly Cys Thr Lys Ala Tyr Tyr Lys           
        195                 200                 205                       

tcg tcg cac ctc aag tcc cac cag cgc acc cac acg ggt gag cgc cct        672
Ser Ser His Leu Lys Ser His Gln Arg Thr His Thr Gly Glu Arg Pro           
    210                 215                 220                           

ttc tcc tgc gac tgg ctc gac tgc gac aag aag ttt acg cgt tcc gac        720
Phe Ser Cys Asp Trp Leu Asp Cys Asp Lys Lys Phe Thr Arg Ser Asp           
225                 230                 235                 240           

gag ctg gcc cgc cac tac agg acg cac acg ggc gag aag cgc ttc tcc        768
Glu Leu Ala Arg His Tyr Arg Thr His Thr Gly Glu Lys Arg Phe Ser           
                245                 250                 255               

tgc ccc ctc tgc ccc aag cag ttc tcc cgg agc gac cac ctg acc aag        816
Cys Pro Leu Cys Pro Lys Gln Phe Ser Arg Ser Asp His Leu Thr Lys           
            260                 265                 270                   

cat gct cgc cgc cac cca acc tat cat cca gat atg atc gag tac cgg        864
His Ala Arg Arg His Pro Thr Tyr His Pro Asp Met Ile Glu Tyr Arg           
        275                 280                 285                       

gga cgt cgt cga act ccc cgc atc gac ccg cca ctc acc agc gag gtg        912
Gly Arg Arg Arg Thr Pro Arg Ile Asp Pro Pro Leu Thr Ser Glu Val           
    290                 295                 300                           

gaa agc tcc gcc tcc ggc tcc ggt ccc ggc ccg gcg ccc agc ttc acc        960
Glu Ser Ser Ala Ser Gly Ser Gly Pro Gly Pro Ala Pro Ser Phe Thr           
305                 310                 315                 320           

acc tgc ctg tag gacagtcatt gctgtcagtc ttaccctcaa ggatgatccc           1012
Thr Cys Leu                                                               
                                                                          

ccaggccgtt gtccctgctt tctctctgcc catccttctt tcccagagtc attacaccaa     1072

ggcacagact ggttcctctg ctctgagggt gggtccaggc agacatgtgg actctgggga     1132

ggtactgggg gccggaaaat agcgggaatt cttgcaacgt gtatatcatc ctaaaagtgg     1192

gggttgcctc aagacagccc ccaggaactg ataagaaggg atgaactccc gtactctcca     1252

gagtactgaa gattctcccc tccctggaac cagggatgtg aaactggaat tctcagatgc     1312

ctgaggagct cccagtctca aaggactctg gtgtctcacc catccaccag gcggaccttg     1372

gagagggtgt c                                                          1383


<210>  214
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Ser Ala Ala Val Ala Cys Leu Asp Tyr Phe Ala Ala Glu Cys Leu 
1               5                   10                  15      


Val Ser Met Ser Ala Gly Ala Val Val His Arg Arg Pro Pro Asp Pro 
            20                  25                  30          


Glu Gly Ala Gly Gly Ala Ala Gly Ser Glu Val Gly Ala Ala His Pro 
        35                  40                  45              


Glu Ser Ala Leu Pro Gly Pro Gly Pro Ser Gly Pro Ala Ser Val Pro 
    50                  55                  60                  


Gln Leu Pro Gln Val Pro Ala Pro Ser Pro Gly Ala Gly Gly Ala Ala 
65                  70                  75                  80  


Pro His Leu Leu Ala Ala Ser Val Trp Ala Asp Leu Arg Gly Ser Ser 
                85                  90                  95      


Gly Glu Gly Ser Trp Glu Asn Ser Gly Glu Ala Pro Arg Ala Ser Ser 
            100                 105                 110         


Gly Phe Ser Asp Pro Ile Pro Cys Ser Val Gln Thr Pro Cys Ser Glu 
        115                 120                 125             


Leu Ala Pro Ala Ser Gly Ala Ala Ala Val Cys Ala Pro Glu Ser Ser 
    130                 135                 140                 


Ser Asp Ala Pro Ala Val Pro Ser Ala Pro Ala Ala Pro Gly Ala Pro 
145                 150                 155                 160 


Ala Ala Ser Gly Gly Phe Ser Gly Gly Ala Leu Gly Ala Gly Pro Ala 
                165                 170                 175     


Pro Ala Ala Asp Gln Ala Pro Arg Arg Arg Ser Val Thr Pro Ala Ala 
            180                 185                 190         


Lys Arg His Gln Cys Pro Phe Pro Gly Cys Thr Lys Ala Tyr Tyr Lys 
        195                 200                 205             


Ser Ser His Leu Lys Ser His Gln Arg Thr His Thr Gly Glu Arg Pro 
    210                 215                 220                 


Phe Ser Cys Asp Trp Leu Asp Cys Asp Lys Lys Phe Thr Arg Ser Asp 
225                 230                 235                 240 


Glu Leu Ala Arg His Tyr Arg Thr His Thr Gly Glu Lys Arg Phe Ser 
                245                 250                 255     


Cys Pro Leu Cys Pro Lys Gln Phe Ser Arg Ser Asp His Leu Thr Lys 
            260                 265                 270         


His Ala Arg Arg His Pro Thr Tyr His Pro Asp Met Ile Glu Tyr Arg 
        275                 280                 285             


Gly Arg Arg Arg Thr Pro Arg Ile Asp Pro Pro Leu Thr Ser Glu Val 
    290                 295                 300                 


Glu Ser Ser Ala Ser Gly Ser Gly Pro Gly Pro Ala Pro Ser Phe Thr 
305                 310                 315                 320 


Thr Cys Leu 
            


<210>  215
<211>  2499
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (85)..(1305)

<400>  215
acaaccaggc ggcagcggat acaaggccag gcggcggcgg gcgggcggac ctgcgccctg       60

agcctttctg cgcccgcggg cacc atg agc agc cga gtc ggg gac ctg agc         111
                           Met Ser Ser Arg Val Gly Asp Leu Ser            
                           1               5                              

ccc cag cag cag gaa gcg ctg gcc agg ttc cgg gag aac ctc cag gac        159
Pro Gln Gln Gln Glu Ala Leu Ala Arg Phe Arg Glu Asn Leu Gln Asp           
10                  15                  20                  25            

ctg ctg ccc ata ctg ccc aat gct gat gac tac ttc ctc ctg cgc tgg        207
Leu Leu Pro Ile Leu Pro Asn Ala Asp Asp Tyr Phe Leu Leu Arg Trp           
                30                  35                  40                

ctg cga gct cga aac ttt gac ctg cag aaa tcc gaa gac atg ctc cga        255
Leu Arg Ala Arg Asn Phe Asp Leu Gln Lys Ser Glu Asp Met Leu Arg           
            45                  50                  55                    

agg cac atg gag ttc cgg aag caa caa gac ctg gac aac att gtc aca        303
Arg His Met Glu Phe Arg Lys Gln Gln Asp Leu Asp Asn Ile Val Thr           
        60                  65                  70                        

tgg cag ccc cct gag gtc atc cag ctg tat gac tcg ggt ggt ctt tgt        351
Trp Gln Pro Pro Glu Val Ile Gln Leu Tyr Asp Ser Gly Gly Leu Cys           
    75                  80                  85                            

ggc tac gac tac gaa ggc tgc cct gtg tac ttc aac atc att ggg tcc        399
Gly Tyr Asp Tyr Glu Gly Cys Pro Val Tyr Phe Asn Ile Ile Gly Ser           
90                  95                  100                 105           

ctc gac ccc aag ggt ctc ctg ctg tca gcc tcc aag cag gat atg atc        447
Leu Asp Pro Lys Gly Leu Leu Leu Ser Ala Ser Lys Gln Asp Met Ile           
                110                 115                 120               

cgg aag cgc atc aaa gtc tgt gag ctg ctg ttg cat gag tgt gag ctg        495
Arg Lys Arg Ile Lys Val Cys Glu Leu Leu Leu His Glu Cys Glu Leu           
            125                 130                 135                   

caa act cag aag ctg ggc agg aag atc gag atg gcg ctg atg gtg ttt        543
Gln Thr Gln Lys Leu Gly Arg Lys Ile Glu Met Ala Leu Met Val Phe           
        140                 145                 150                       

gac atg gag ggg ctg agc ctg aaa cac ctg tgg aag cca gct gtg gag        591
Asp Met Glu Gly Leu Ser Leu Lys His Leu Trp Lys Pro Ala Val Glu           
    155                 160                 165                           

gtc tac cag cag ttt ttt agc atc ctg gaa gca aat tat cct gag acc        639
Val Tyr Gln Gln Phe Phe Ser Ile Leu Glu Ala Asn Tyr Pro Glu Thr           
170                 175                 180                 185           

ctg aag aat tta att gtt att cga gcc cca aaa ctg ttc ccc gtg gcc        687
Leu Lys Asn Leu Ile Val Ile Arg Ala Pro Lys Leu Phe Pro Val Ala           
                190                 195                 200               

ttc aac ttg gtc aag tcg ttc atg agt gag gag aca cgc agg aag att        735
Phe Asn Leu Val Lys Ser Phe Met Ser Glu Glu Thr Arg Arg Lys Ile           
            205                 210                 215                   

gtg att ctg gga gac aac tgg aag cag gag ctg aca aaa ttc atc agc        783
Val Ile Leu Gly Asp Asn Trp Lys Gln Glu Leu Thr Lys Phe Ile Ser           
        220                 225                 230                       

ccc gac cag ctg cct gtg gag ttt ggg ggg acc atg act gac ccc gat        831
Pro Asp Gln Leu Pro Val Glu Phe Gly Gly Thr Met Thr Asp Pro Asp           
    235                 240                 245                           

ggc aac ccc aag tgc ctg acc aag atc aac tat ggg ggt gag gtg ccc        879
Gly Asn Pro Lys Cys Leu Thr Lys Ile Asn Tyr Gly Gly Glu Val Pro           
250                 255                 260                 265           

aag agc tac tac ctg tgc gag cag gtg agg ctg cag tat gag cac acg        927
Lys Ser Tyr Tyr Leu Cys Glu Gln Val Arg Leu Gln Tyr Glu His Thr           
                270                 275                 280               

agg tcc gtg ggc cgc ggc tcc tcc ctg cag gtg gag aac gag atc ctg        975
Arg Ser Val Gly Arg Gly Ser Ser Leu Gln Val Glu Asn Glu Ile Leu           
            285                 290                 295                   

ttc ccg ggc tgt gtg ctc agg tgg cag ttt gct tca gat ggt ggg gac       1023
Phe Pro Gly Cys Val Leu Arg Trp Gln Phe Ala Ser Asp Gly Gly Asp           
        300                 305                 310                       

atc ggc ttt ggg gtt ttc ctg aag acc aag atg ggg gag cag cag agt       1071
Ile Gly Phe Gly Val Phe Leu Lys Thr Lys Met Gly Glu Gln Gln Ser           
    315                 320                 325                           

gct agg gag atg acg gag gtg ctg ccc agc cag cgc tac aat gcc cac       1119
Ala Arg Glu Met Thr Glu Val Leu Pro Ser Gln Arg Tyr Asn Ala His           
330                 335                 340                 345           

atg gtg cct gag gat ggg agc ctc acc tgc ctc cag gct ggc gtc tat       1167
Met Val Pro Glu Asp Gly Ser Leu Thr Cys Leu Gln Ala Gly Val Tyr           
                350                 355                 360               

gtc ctg cgc ttc gac aac acc tac agc cgg atg cat gcc aag aag ctc       1215
Val Leu Arg Phe Asp Asn Thr Tyr Ser Arg Met His Ala Lys Lys Leu           
            365                 370                 375                   

agc tac act gtg gag gtg ctg ctt ccc gac aag gcc tct gag gag acg       1263
Ser Tyr Thr Val Glu Val Leu Leu Pro Asp Lys Ala Ser Glu Glu Thr           
        380                 385                 390                       

ctg cag agt ctc aag gcg atg aga ccc tcc cca aca cag tga               1305
Leu Gln Ser Leu Lys Ala Met Arg Pro Ser Pro Thr Gln                       
    395                 400                 405                           

agaccccagc cacctctacc tgtgcactcc aaccccttca cacccacccc tctgacccct     1365

gccttcccag gcagggtggt gctggaggtg gctgcagaga gccacttgtc ccacgtcacc     1425

atttcatctc attgtaggct cacctggcac agtggccaag caggaagggg ccaccagtgc     1485

atagcccatg ctgaagattc agacaggaac ctctttccct gttcccagag aatgcggctg     1545

agaatgagaa cgctgaagat gatccagtcc actgaggatg ggtcctgctt gcagaagctg     1605

ccctttcacc catcttgaca agatccagcc acccaggact cacccatgcc tggtgttcca     1665

gcttcagggg gtgtgcgtgg ttcctaggtc ctgtggacat cacagcttca ggcctgaaga     1725

gcagagaagc cctgttctct gcatgtagga ggtcagcagg ggtgggcagg cccagctgga     1785

ggcagctggg tgagggtcct ggttccagca gagcactggg gcccatccaa gtttgttctg     1845

ccaccactgg atggaaaatt ggaaatggac tgggcgtggt ggctcacgcc tataatccca     1905

gcagtttggg aggctgagtt gggcagatca cctgagatca ggagttcggg accagcctgg     1965

gcaacatggt gaaaccctgt ctctactaaa aatacaaaaa ttagccgggc atggtggcgt     2025

gcacctgtaa tcccagctac tcaggaggct gaggcaggag aatcgcttgt acccaggagg     2085

cggaggttgt agtgagctga gatcgtgcca ctgcactcca gcctgggcaa cagagccaga     2145

ctccgtctct aaacaaacaa acaaacaaac aaacaaataa agaaagaaca ttggacatgg     2205

agaggtgggg cctggcatgg gtaaccatca gaggaaaaag ccatgctcag ccttccagtt     2265

gagtgggtaa cgactgagtc tccagggaat tcccagtgac ctcccctcca cacctgctgt     2325

gatcctgcca acatttagct ttggttctct tggcagctgc accattcatg ggtgcatata     2385

cgtagagtct gaacaggtgc tctgctgcta gaaacagcaa accatctaga ttaaactcct     2445

aaagccagtg ccacgaggca ttcctgttcc aactgggtgt ttgagcagat tggc           2499


<210>  216
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Ser Ser Arg Val Gly Asp Leu Ser Pro Gln Gln Gln Glu Ala Leu 
1               5                   10                  15      


Ala Arg Phe Arg Glu Asn Leu Gln Asp Leu Leu Pro Ile Leu Pro Asn 
            20                  25                  30          


Ala Asp Asp Tyr Phe Leu Leu Arg Trp Leu Arg Ala Arg Asn Phe Asp 
        35                  40                  45              


Leu Gln Lys Ser Glu Asp Met Leu Arg Arg His Met Glu Phe Arg Lys 
    50                  55                  60                  


Gln Gln Asp Leu Asp Asn Ile Val Thr Trp Gln Pro Pro Glu Val Ile 
65                  70                  75                  80  


Gln Leu Tyr Asp Ser Gly Gly Leu Cys Gly Tyr Asp Tyr Glu Gly Cys 
                85                  90                  95      


Pro Val Tyr Phe Asn Ile Ile Gly Ser Leu Asp Pro Lys Gly Leu Leu 
            100                 105                 110         


Leu Ser Ala Ser Lys Gln Asp Met Ile Arg Lys Arg Ile Lys Val Cys 
        115                 120                 125             


Glu Leu Leu Leu His Glu Cys Glu Leu Gln Thr Gln Lys Leu Gly Arg 
    130                 135                 140                 


Lys Ile Glu Met Ala Leu Met Val Phe Asp Met Glu Gly Leu Ser Leu 
145                 150                 155                 160 


Lys His Leu Trp Lys Pro Ala Val Glu Val Tyr Gln Gln Phe Phe Ser 
                165                 170                 175     


Ile Leu Glu Ala Asn Tyr Pro Glu Thr Leu Lys Asn Leu Ile Val Ile 
            180                 185                 190         


Arg Ala Pro Lys Leu Phe Pro Val Ala Phe Asn Leu Val Lys Ser Phe 
        195                 200                 205             


Met Ser Glu Glu Thr Arg Arg Lys Ile Val Ile Leu Gly Asp Asn Trp 
    210                 215                 220                 


Lys Gln Glu Leu Thr Lys Phe Ile Ser Pro Asp Gln Leu Pro Val Glu 
225                 230                 235                 240 


Phe Gly Gly Thr Met Thr Asp Pro Asp Gly Asn Pro Lys Cys Leu Thr 
                245                 250                 255     


Lys Ile Asn Tyr Gly Gly Glu Val Pro Lys Ser Tyr Tyr Leu Cys Glu 
            260                 265                 270         


Gln Val Arg Leu Gln Tyr Glu His Thr Arg Ser Val Gly Arg Gly Ser 
        275                 280                 285             


Ser Leu Gln Val Glu Asn Glu Ile Leu Phe Pro Gly Cys Val Leu Arg 
    290                 295                 300                 


Trp Gln Phe Ala Ser Asp Gly Gly Asp Ile Gly Phe Gly Val Phe Leu 
305                 310                 315                 320 


Lys Thr Lys Met Gly Glu Gln Gln Ser Ala Arg Glu Met Thr Glu Val 
                325                 330                 335     


Leu Pro Ser Gln Arg Tyr Asn Ala His Met Val Pro Glu Asp Gly Ser 
            340                 345                 350         


Leu Thr Cys Leu Gln Ala Gly Val Tyr Val Leu Arg Phe Asp Asn Thr 
        355                 360                 365             


Tyr Ser Arg Met His Ala Lys Lys Leu Ser Tyr Thr Val Glu Val Leu 
    370                 375                 380                 


Leu Pro Asp Lys Ala Ser Glu Glu Thr Leu Gln Ser Leu Lys Ala Met 
385                 390                 395                 400 


Arg Pro Ser Pro Thr Gln 
                405     


<210>  217
<211>  1996
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (78)..(947)

<400>  217
agacgcctga gtcggagaga cagggggcag aggttgccaa gccctggctg ccacttgtca       60

ggttccctgt gctagac atg cat aat ctg tat tcc atc act ggg tac ccg         110
                   Met His Asn Leu Tyr Ser Ile Thr Gly Tyr Pro            
                   1               5                   10                 

gac cca cca ggg acc atg gag gag gag gag gag gat gat gac tat gag        158
Asp Pro Pro Gly Thr Met Glu Glu Glu Glu Glu Asp Asp Asp Tyr Glu           
            15                  20                  25                    

aac tca aca cct ccc tac aag gac ctt cct ccc aag cca ggg acc atg        206
Asn Ser Thr Pro Pro Tyr Lys Asp Leu Pro Pro Lys Pro Gly Thr Met           
        30                  35                  40                        

gag gag gag gag gag gat gat gac tat gag aac tca aca cct ccc tac        254
Glu Glu Glu Glu Glu Asp Asp Asp Tyr Glu Asn Ser Thr Pro Pro Tyr           
    45                  50                  55                            

aag gac ctt cct ccc aag cca gcc ctc acc ctg agc ttc tct tct cca        302
Lys Asp Leu Pro Pro Lys Pro Ala Leu Thr Leu Ser Phe Ser Ser Pro           
60                  65                  70                  75            

ggt tca agt gct cca cca aga cct cca agg gca gca aag gaa aca gag        350
Gly Ser Ser Ala Pro Pro Arg Pro Pro Arg Ala Ala Lys Glu Thr Glu           
                80                  85                  90                

aaa ccc cca ctt cct tgc aag ccc cgg aac atg aca ggc ctg gac ctc        398
Lys Pro Pro Leu Pro Cys Lys Pro Arg Asn Met Thr Gly Leu Asp Leu           
            95                  100                 105                   

gcc gct gtc acc tgt cca cct cct caa ctg gct gtg aat ctt gag cct        446
Ala Ala Val Thr Cys Pro Pro Pro Gln Leu Ala Val Asn Leu Glu Pro           
        110                 115                 120                       

tct cca ttg cag cca tcc ctg gcc gca act cca gtc ccc tgg ctc aat        494
Ser Pro Leu Gln Pro Ser Leu Ala Ala Thr Pro Val Pro Trp Leu Asn           
    125                 130                 135                           

cag agg tct gga ggt cct ggc tgc tgc cag aag agg tgg atg gtg tac        542
Gln Arg Ser Gly Gly Pro Gly Cys Cys Gln Lys Arg Trp Met Val Tyr           
140                 145                 150                 155           

ctg tgt ctg ctg gtg gtg act tcc ctg ttc ctg ggc tgc ctt ggt ctc        590
Leu Cys Leu Leu Val Val Thr Ser Leu Phe Leu Gly Cys Leu Gly Leu           
                160                 165                 170               

act gtg acc ctg att aag tac cag gag ttg atg gaa gaa ctg aga atg        638
Thr Val Thr Leu Ile Lys Tyr Gln Glu Leu Met Glu Glu Leu Arg Met           
            175                 180                 185                   

tta agc ttt cag cag atg acg tgg cga aca aat atg act ggc atg gca        686
Leu Ser Phe Gln Gln Met Thr Trp Arg Thr Asn Met Thr Gly Met Ala           
        190                 195                 200                       

ggg cta gct ggc ctg aag cat gac att gcc cgt gta aga gct gac acc        734
Gly Leu Ala Gly Leu Lys His Asp Ile Ala Arg Val Arg Ala Asp Thr           
    205                 210                 215                           

aac cag tcc ctg gtg gaa ctt tgg ggc tta tta gac tgc cgc cga att        782
Asn Gln Ser Leu Val Glu Leu Trp Gly Leu Leu Asp Cys Arg Arg Ile           
220                 225                 230                 235           

acc tgt cct gaa ggc tgg ctg ccc ttt gag ggc aag tgt tac tac ttc        830
Thr Cys Pro Glu Gly Trp Leu Pro Phe Glu Gly Lys Cys Tyr Tyr Phe           
                240                 245                 250               

tcc cca agc acc aag tca tgg gat gag gcc cgg atg ttc tgc cag gag        878
Ser Pro Ser Thr Lys Ser Trp Asp Glu Ala Arg Met Phe Cys Gln Glu           
            255                 260                 265                   

aat tac tct cac ttg gtc atc atc aat agc ttt gct gag cac ctt ctg        926
Asn Tyr Ser His Leu Val Ile Ile Asn Ser Phe Ala Glu His Leu Leu           
        270                 275                 280                       

gga gcc aga gga acc caa taa catccacgat gaggactgtg ctaccatgaa           977
Gly Ala Arg Gly Thr Gln                                                   
    285                                                                   

caaaggtggc acctggaatg atctctcttg ctacaaaact acgtattgga tttgtgagcg     1037

gaaatgttcc tgttgaagcc cagggccgag gctgggggtc catatctgag tgtctctttg     1097

agatgagaat ctcctgccct ttcgtggacg gccttgcctc ttcgtgagtg gacacacaga     1157

tgtgcctcaa acaggattgg caccctggat gcagcaagtt cccaggggtg caagtcaggc     1217

tgtttctaga gtgaggactt gggcttgccc tagtagatgg tgagctggga ggatgctcag     1277

agcttggtgg tgggaggtct cccacttctg gggttgaaag gatcttcact aagttcctga     1337

tcatgactct tgggaagtga tactagccct gaggaccctg gggctggtgt tgaacctggg     1397

atgaaatatc ctggcgcctg tgaaccacaa agagctggga ctgggctcct tttcctgcag     1457

cctcaaactt ctgggctcag gtgatcctcc catctcagcc tcctgagtag ctgggactac     1517

acatgcgcac caccatgcct ggccaatttt ttgtagcatt taaagagagg gagtctcact     1577

atgttgccca ggccagtctc aaactccttg cctcaatgga tcctcctact tgggcttccc     1637

aaattgtgag gattacaggt gtgagccact gtgcctggct caaaattatt attattattt     1697

ttatagagat gaggtctcac tctgttgccg aggctggtct caaactcctg gggtcaagca     1757

atccttccgt gatggcctcc caaagtgctg ggattacagg catgtgtcac cgtacctggc     1817

cgatattttt atttttattt ttactttccc catcttttcc tttttttttt ttttccaaac     1877

aaaagctttg aaagtggtga cagaaaaatt tccctttgag ctagacctct agatctgcct     1937

cgcacagaaa tacattaagt gggctggtct catgtagtcc ccacatcatt gcaaattac      1996


<210>  218
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  218

Met His Asn Leu Tyr Ser Ile Thr Gly Tyr Pro Asp Pro Pro Gly Thr 
1               5                   10                  15      


Met Glu Glu Glu Glu Glu Asp Asp Asp Tyr Glu Asn Ser Thr Pro Pro 
            20                  25                  30          


Tyr Lys Asp Leu Pro Pro Lys Pro Gly Thr Met Glu Glu Glu Glu Glu 
        35                  40                  45              


Asp Asp Asp Tyr Glu Asn Ser Thr Pro Pro Tyr Lys Asp Leu Pro Pro 
    50                  55                  60                  


Lys Pro Ala Leu Thr Leu Ser Phe Ser Ser Pro Gly Ser Ser Ala Pro 
65                  70                  75                  80  


Pro Arg Pro Pro Arg Ala Ala Lys Glu Thr Glu Lys Pro Pro Leu Pro 
                85                  90                  95      


Cys Lys Pro Arg Asn Met Thr Gly Leu Asp Leu Ala Ala Val Thr Cys 
            100                 105                 110         


Pro Pro Pro Gln Leu Ala Val Asn Leu Glu Pro Ser Pro Leu Gln Pro 
        115                 120                 125             


Ser Leu Ala Ala Thr Pro Val Pro Trp Leu Asn Gln Arg Ser Gly Gly 
    130                 135                 140                 


Pro Gly Cys Cys Gln Lys Arg Trp Met Val Tyr Leu Cys Leu Leu Val 
145                 150                 155                 160 


Val Thr Ser Leu Phe Leu Gly Cys Leu Gly Leu Thr Val Thr Leu Ile 
                165                 170                 175     


Lys Tyr Gln Glu Leu Met Glu Glu Leu Arg Met Leu Ser Phe Gln Gln 
            180                 185                 190         


Met Thr Trp Arg Thr Asn Met Thr Gly Met Ala Gly Leu Ala Gly Leu 
        195                 200                 205             


Lys His Asp Ile Ala Arg Val Arg Ala Asp Thr Asn Gln Ser Leu Val 
    210                 215                 220                 


Glu Leu Trp Gly Leu Leu Asp Cys Arg Arg Ile Thr Cys Pro Glu Gly 
225                 230                 235                 240 


Trp Leu Pro Phe Glu Gly Lys Cys Tyr Tyr Phe Ser Pro Ser Thr Lys 
                245                 250                 255     


Ser Trp Asp Glu Ala Arg Met Phe Cys Gln Glu Asn Tyr Ser His Leu 
            260                 265                 270         


Val Ile Ile Asn Ser Phe Ala Glu His Leu Leu Gly Ala Arg Gly Thr 
        275                 280                 285             


Gln 
    


<210>  219
<211>  2545
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (375)..(2027)

<400>  219
atctgcctga ctttcacttt tggtgctgga gaactcagaa ggtggctcag ccctctggtc       60

cacacttggt gggcagctcg gatgccccag gcagcccggg cacagtgagc ttagtcccct      120

tcaccccctc cgcagagctc tggggcatcc gcacagtcac tcctggacac aagataagga      180

ggagtttccc cgaggcatca cagggcttcc cgggactgag ggactgactc aactggttat      240

tggacagtgc cccaccccca atccggctga ggggcaggaa ggcagaaggt cttggtggcc      300

ctggatcttg tggctgcaat cggttccaaa cagcagttag gtcagcagtc cgctcagccg      360

aggcagctct gttc atg gcg ttc tcg aag ctc ttg gag caa gcc gga ggc        410
                Met Ala Phe Ser Lys Leu Leu Glu Gln Ala Gly Gly           
                1               5                   10                    

gtg ggc ctc ttc cag acc ctg cag gtg ctc acc ttc atc ctc ccc tgc        458
Val Gly Leu Phe Gln Thr Leu Gln Val Leu Thr Phe Ile Leu Pro Cys           
        15                  20                  25                        

ctc atg ata cct tcc cag atg ctc ctg gag aac ttc tca gcc gcc atc        506
Leu Met Ile Pro Ser Gln Met Leu Leu Glu Asn Phe Ser Ala Ala Ile           
    30                  35                  40                            

cca ggc cac cga tgc tgg aca cac atg ctg gac aat ggc tct gcg gtt        554
Pro Gly His Arg Cys Trp Thr His Met Leu Asp Asn Gly Ser Ala Val           
45                  50                  55                  60            

tcc aca aac atg acc ccc aag gcc ctt ctg acc atc tcc atc ccg cca        602
Ser Thr Asn Met Thr Pro Lys Ala Leu Leu Thr Ile Ser Ile Pro Pro           
                65                  70                  75                

ggc ccc aac cag ggg ccc cac cag tgc cgc cgc ttc cgc cag cca cag        650
Gly Pro Asn Gln Gly Pro His Gln Cys Arg Arg Phe Arg Gln Pro Gln           
            80                  85                  90                    

tgg cag ctc ttg gac ccc aat gcc acg gcc acc agc tgg agc gaa gct        698
Trp Gln Leu Leu Asp Pro Asn Ala Thr Ala Thr Ser Trp Ser Glu Ala           
        95                  100                 105                       

gac acg gag ccg tgt gtg gac ggc tgg gtc tat gac cgc agc gtc ttc        746
Asp Thr Glu Pro Cys Val Asp Gly Trp Val Tyr Asp Arg Ser Val Phe           
    110                 115                 120                           

acc tcc acc atc gtg gcc aag tgg gac ctg gtg tgc agc tcc cag ggc        794
Thr Ser Thr Ile Val Ala Lys Trp Asp Leu Val Cys Ser Ser Gln Gly           
125                 130                 135                 140           

ttg aag ccc cta agc cag tcc atc ttc atg tcc ggg atc ctg gtg ggc        842
Leu Lys Pro Leu Ser Gln Ser Ile Phe Met Ser Gly Ile Leu Val Gly           
                145                 150                 155               

tcc ttt atc tgg ggc ctc ctc tcc tac cgg ttt ggg agg aag ccg atg        890
Ser Phe Ile Trp Gly Leu Leu Ser Tyr Arg Phe Gly Arg Lys Pro Met           
            160                 165                 170                   

ctg agc tgg tgc tgc ctg cag ttg gcc gtg gcg ggc acc agc acc atc        938
Leu Ser Trp Cys Cys Leu Gln Leu Ala Val Ala Gly Thr Ser Thr Ile           
        175                 180                 185                       

ttc gcc cca aca ttc gtc atc tac tgc ggc ctg cgg ttc gtg gcc gct        986
Phe Ala Pro Thr Phe Val Ile Tyr Cys Gly Leu Arg Phe Val Ala Ala           
    190                 195                 200                           

ttt ggg atg gcc ggc atc ttt ctg agt tca ctg aca ctg atg gtg gag       1034
Phe Gly Met Ala Gly Ile Phe Leu Ser Ser Leu Thr Leu Met Val Glu           
205                 210                 215                 220           

tgg acc acg acc agc agg agg gcg gtc acc atg acg gtg gtg gga tgt       1082
Trp Thr Thr Thr Ser Arg Arg Ala Val Thr Met Thr Val Val Gly Cys           
                225                 230                 235               

gcc ttc agc gca ggc cag gcg gcg ctg ggc ggc ctg gcc ttt gcc ctg       1130
Ala Phe Ser Ala Gly Gln Ala Ala Leu Gly Gly Leu Ala Phe Ala Leu           
            240                 245                 250                   

cgg gac tgg agg act ctc cag ctg gca gca tca gtg ccc ttc ttt gcc       1178
Arg Asp Trp Arg Thr Leu Gln Leu Ala Ala Ser Val Pro Phe Phe Ala           
        255                 260                 265                       

atc tcc ctg ata tcc tgg tgg ctg cca gaa tcc gcc cgg tgg ctg att       1226
Ile Ser Leu Ile Ser Trp Trp Leu Pro Glu Ser Ala Arg Trp Leu Ile           
    270                 275                 280                           

att aag ggc aaa cca gac caa gca ctt cag gag ctc aga aag gtg gcc       1274
Ile Lys Gly Lys Pro Asp Gln Ala Leu Gln Glu Leu Arg Lys Val Ala           
285                 290                 295                 300           

agg ata aat ggc cac aag gag gcc aag aac ctg acc ata gag gtg ctg       1322
Arg Ile Asn Gly His Lys Glu Ala Lys Asn Leu Thr Ile Glu Val Leu           
                305                 310                 315               

atg tcc agc gtg aag gag gag gtg gcc tct gca aag gag ccg cgg tcg       1370
Met Ser Ser Val Lys Glu Glu Val Ala Ser Ala Lys Glu Pro Arg Ser           
            320                 325                 330                   

gtg ctg gac ctg ttc tgc gtg ccc gtg ctc cgc tgg agg agc tgc gcc       1418
Val Leu Asp Leu Phe Cys Val Pro Val Leu Arg Trp Arg Ser Cys Ala           
        335                 340                 345                       

atg ctg gtg gtg aat ttc tct cta ttg atc tcc tac tat ggg ctg gtc       1466
Met Leu Val Val Asn Phe Ser Leu Leu Ile Ser Tyr Tyr Gly Leu Val           
    350                 355                 360                           

ttc gac ctg cag agc ctg ggc cgt gac atc ttc ctc ctc cag gcc ctc       1514
Phe Asp Leu Gln Ser Leu Gly Arg Asp Ile Phe Leu Leu Gln Ala Leu           
365                 370                 375                 380           

ttc ggg gcc gtg gac ttc ctg ggc cgg gcc acc act gcc ctc ttg ctc       1562
Phe Gly Ala Val Asp Phe Leu Gly Arg Ala Thr Thr Ala Leu Leu Leu           
                385                 390                 395               

agt ttc ctt ggc cgc cgc acc atc cag gcg ggt tcc cag gcc atg gcc       1610
Ser Phe Leu Gly Arg Arg Thr Ile Gln Ala Gly Ser Gln Ala Met Ala           
            400                 405                 410                   

ggc ctc gcc att cta gcc aac atg ctg gtg ccg caa gat ttg cag acc       1658
Gly Leu Ala Ile Leu Ala Asn Met Leu Val Pro Gln Asp Leu Gln Thr           
        415                 420                 425                       

ctg cgt gtg gtc ttt gct gtg ctg gga aag gga tgt ttt ggg ata agc       1706
Leu Arg Val Val Phe Ala Val Leu Gly Lys Gly Cys Phe Gly Ile Ser           
    430                 435                 440                           

cta acc tgc ctc acc atc tac aag gct gaa ctc ttt cca acg cca gtg       1754
Leu Thr Cys Leu Thr Ile Tyr Lys Ala Glu Leu Phe Pro Thr Pro Val           
445                 450                 455                 460           

cgg atg aca gca gat ggc att ctg cat aca gtg ggc cgg ctg ggg gct       1802
Arg Met Thr Ala Asp Gly Ile Leu His Thr Val Gly Arg Leu Gly Ala           
                465                 470                 475               

atg atg ggt ccc ctg atc ctg atg agc cgc caa gcc ctg ccc ctg ctg       1850
Met Met Gly Pro Leu Ile Leu Met Ser Arg Gln Ala Leu Pro Leu Leu           
            480                 485                 490                   

cct cct ctc ctc tat ggc gtt atc tcc att gct tcc agc ctg gtt gtg       1898
Pro Pro Leu Leu Tyr Gly Val Ile Ser Ile Ala Ser Ser Leu Val Val           
        495                 500                 505                       

ctg ttc ttc ctc ccg gag acc cag gga ctt ccg ctc cct gac act atc       1946
Leu Phe Phe Leu Pro Glu Thr Gln Gly Leu Pro Leu Pro Asp Thr Ile           
    510                 515                 520                           

cag gac ctg gag agc cag aaa tca aca gca gcc cag ggc aac cgg caa       1994
Gln Asp Leu Glu Ser Gln Lys Ser Thr Ala Ala Gln Gly Asn Arg Gln           
525                 530                 535                 540           

gag gcc gtc act gtg gaa agt acc tcg ctc tag aaattgtgcc tgcatggagc     2047
Glu Ala Val Thr Val Glu Ser Thr Ser Leu                                   
                545                 550                                   

ccctttagtc aaagactcct ggaaaggagt tgcctcttct ccaatcagag cgtggaggcg     2107

agttgggcga cttcaagggc ctggcatggc agaggccagg cagccgtggc cgagtggaca     2167

gcgtggccgt ctgctgtggc tgaaggcagc ttccacagct cactcctctt ctccctgccc     2227

tgatcagatt ccccacctta cccgggccct acaggagcct gtgcagatgg ccatgcccaa     2287

ccaataacga gacggttccc ctccctttcc ctgccaggct catgtcttta caccttcact     2347

cagccacgcc aaccagagac tgggttccaa tctcacccca ccacatacag agccctcatc     2407

tgtgaaatga gaatgatcac gtgacccacc ccccagggca ggtatcaggg tgaactgatc     2467

ttagcaccgg ccaaataaat ggaacctgct gagagagctg ccagaaaaaa aaaaaaaaaa     2527

aaaaaaaaaa aaaaaaaa                                                   2545


<210>  220
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Ala Phe Ser Lys Leu Leu Glu Gln Ala Gly Gly Val Gly Leu Phe 
1               5                   10                  15      


Gln Thr Leu Gln Val Leu Thr Phe Ile Leu Pro Cys Leu Met Ile Pro 
            20                  25                  30          


Ser Gln Met Leu Leu Glu Asn Phe Ser Ala Ala Ile Pro Gly His Arg 
        35                  40                  45              


Cys Trp Thr His Met Leu Asp Asn Gly Ser Ala Val Ser Thr Asn Met 
    50                  55                  60                  


Thr Pro Lys Ala Leu Leu Thr Ile Ser Ile Pro Pro Gly Pro Asn Gln 
65                  70                  75                  80  


Gly Pro His Gln Cys Arg Arg Phe Arg Gln Pro Gln Trp Gln Leu Leu 
                85                  90                  95      


Asp Pro Asn Ala Thr Ala Thr Ser Trp Ser Glu Ala Asp Thr Glu Pro 
            100                 105                 110         


Cys Val Asp Gly Trp Val Tyr Asp Arg Ser Val Phe Thr Ser Thr Ile 
        115                 120                 125             


Val Ala Lys Trp Asp Leu Val Cys Ser Ser Gln Gly Leu Lys Pro Leu 
    130                 135                 140                 


Ser Gln Ser Ile Phe Met Ser Gly Ile Leu Val Gly Ser Phe Ile Trp 
145                 150                 155                 160 


Gly Leu Leu Ser Tyr Arg Phe Gly Arg Lys Pro Met Leu Ser Trp Cys 
                165                 170                 175     


Cys Leu Gln Leu Ala Val Ala Gly Thr Ser Thr Ile Phe Ala Pro Thr 
            180                 185                 190         


Phe Val Ile Tyr Cys Gly Leu Arg Phe Val Ala Ala Phe Gly Met Ala 
        195                 200                 205             


Gly Ile Phe Leu Ser Ser Leu Thr Leu Met Val Glu Trp Thr Thr Thr 
    210                 215                 220                 


Ser Arg Arg Ala Val Thr Met Thr Val Val Gly Cys Ala Phe Ser Ala 
225                 230                 235                 240 


Gly Gln Ala Ala Leu Gly Gly Leu Ala Phe Ala Leu Arg Asp Trp Arg 
                245                 250                 255     


Thr Leu Gln Leu Ala Ala Ser Val Pro Phe Phe Ala Ile Ser Leu Ile 
            260                 265                 270         


Ser Trp Trp Leu Pro Glu Ser Ala Arg Trp Leu Ile Ile Lys Gly Lys 
        275                 280                 285             


Pro Asp Gln Ala Leu Gln Glu Leu Arg Lys Val Ala Arg Ile Asn Gly 
    290                 295                 300                 


His Lys Glu Ala Lys Asn Leu Thr Ile Glu Val Leu Met Ser Ser Val 
305                 310                 315                 320 


Lys Glu Glu Val Ala Ser Ala Lys Glu Pro Arg Ser Val Leu Asp Leu 
                325                 330                 335     


Phe Cys Val Pro Val Leu Arg Trp Arg Ser Cys Ala Met Leu Val Val 
            340                 345                 350         


Asn Phe Ser Leu Leu Ile Ser Tyr Tyr Gly Leu Val Phe Asp Leu Gln 
        355                 360                 365             


Ser Leu Gly Arg Asp Ile Phe Leu Leu Gln Ala Leu Phe Gly Ala Val 
    370                 375                 380                 


Asp Phe Leu Gly Arg Ala Thr Thr Ala Leu Leu Leu Ser Phe Leu Gly 
385                 390                 395                 400 


Arg Arg Thr Ile Gln Ala Gly Ser Gln Ala Met Ala Gly Leu Ala Ile 
                405                 410                 415     


Leu Ala Asn Met Leu Val Pro Gln Asp Leu Gln Thr Leu Arg Val Val 
            420                 425                 430         


Phe Ala Val Leu Gly Lys Gly Cys Phe Gly Ile Ser Leu Thr Cys Leu 
        435                 440                 445             


Thr Ile Tyr Lys Ala Glu Leu Phe Pro Thr Pro Val Arg Met Thr Ala 
    450                 455                 460                 


Asp Gly Ile Leu His Thr Val Gly Arg Leu Gly Ala Met Met Gly Pro 
465                 470                 475                 480 


Leu Ile Leu Met Ser Arg Gln Ala Leu Pro Leu Leu Pro Pro Leu Leu 
                485                 490                 495     


Tyr Gly Val Ile Ser Ile Ala Ser Ser Leu Val Val Leu Phe Phe Leu 
            500                 505                 510         


Pro Glu Thr Gln Gly Leu Pro Leu Pro Asp Thr Ile Gln Asp Leu Glu 
        515                 520                 525             


Ser Gln Lys Ser Thr Ala Ala Gln Gly Asn Arg Gln Glu Ala Val Thr 
    530                 535                 540                 


Val Glu Ser Thr Ser Leu 
545                 550 


<210>  221
<211>  5680
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (204)..(3479)

<400>  221
aacgggctca ttcagcggtc gcgagctgcc cgcgaggggg agcggccgga cggagagcgc       60

gacccgtccc gggggtgggg ccgggcgcag cggcgagagg aggcgaaggt ggctgcggta      120

gcagcagcgc ggcagcctcg gacccagccc ggagcgcagg gcggccgctg caggtccccg      180

ctcccctccc cgtgcgtccg ccc atg gcc gcc gcc ggg cag ctg tgc ttg ctc      233
                          Met Ala Ala Ala Gly Gln Leu Cys Leu Leu         
                          1               5                   10          

tac ctg tcg gcg ggg ctc ctg tcc cgg ctc ggc gca gcc ttc aac ttg        281
Tyr Leu Ser Ala Gly Leu Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu           
                15                  20                  25                

gac act cgg gag gac aac gtg atc cgg aaa tat gga gac ccc ggg agc        329
Asp Thr Arg Glu Asp Asn Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser           
            30                  35                  40                    

ctc ttc ggc ttc tcg ctg gcc atg cac tgg caa ctg cag ccc gag gac        377
Leu Phe Gly Phe Ser Leu Ala Met His Trp Gln Leu Gln Pro Glu Asp           
        45                  50                  55                        

aag cgg ctg ttg ctc gtg ggg gcc ccg cgg gca gaa gcg ctt cca ctg        425
Lys Arg Leu Leu Leu Val Gly Ala Pro Arg Ala Glu Ala Leu Pro Leu           
    60                  65                  70                            

cag aga gcc aac aga acg gga ggg ctg tac agc tgc gac atc acc gcc        473
Gln Arg Ala Asn Arg Thr Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala           
75                  80                  85                  90            

cgg ggg cca tgc acg cgg atc gag ttt gat aac gat gct gac ccc acg        521
Arg Gly Pro Cys Thr Arg Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr           
                95                  100                 105               

tca gaa agc aag gaa gat cag tgg atg ggg gtc acc gtc cag agc caa        569
Ser Glu Ser Lys Glu Asp Gln Trp Met Gly Val Thr Val Gln Ser Gln           
            110                 115                 120                   

ggt cca ggg ggc aag gtc gtg aca tgt gct cac cga tat gaa aaa agg        617
Gly Pro Gly Gly Lys Val Val Thr Cys Ala His Arg Tyr Glu Lys Arg           
        125                 130                 135                       

cag cat gtt aat acg aag cag gaa tcc cga gac atc ttt ggg cgg tgt        665
Gln His Val Asn Thr Lys Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys           
    140                 145                 150                           

tat gtc ctg agt cag aat ctc agg att gaa gac gat atg gat ggg gga        713
Tyr Val Leu Ser Gln Asn Leu Arg Ile Glu Asp Asp Met Asp Gly Gly           
155                 160                 165                 170           

gat tgg agc ttt tgt gat ggg cga ttg aga ggc cat gag aaa ttt ggc        761
Asp Trp Ser Phe Cys Asp Gly Arg Leu Arg Gly His Glu Lys Phe Gly           
                175                 180                 185               

tct tgc cag caa ggt gta gca gct act ttt act aaa gac ttt cat tac        809
Ser Cys Gln Gln Gly Val Ala Ala Thr Phe Thr Lys Asp Phe His Tyr           
            190                 195                 200                   

att gta ttt gga gcc ccg ggt act tat aac tgg aaa ggg att gtt cgt        857
Ile Val Phe Gly Ala Pro Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg           
        205                 210                 215                       

gta gag caa aag aat aac act ttt ttt gac atg aac atc ttt gaa gat        905
Val Glu Gln Lys Asn Asn Thr Phe Phe Asp Met Asn Ile Phe Glu Asp           
    220                 225                 230                           

ggg cct tat gaa gtt ggt gga gag act gag cat gat gaa agt ctc gtt        953
Gly Pro Tyr Glu Val Gly Gly Glu Thr Glu His Asp Glu Ser Leu Val           
235                 240                 245                 250           

cct gtt cct gct aac agt tac tta ggt ttt tct ttg gac tca ggg aaa       1001
Pro Val Pro Ala Asn Ser Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys           
                255                 260                 265               

ggt att gtt tct aaa gat gag atc act ttt gta tct ggt gct ccc aga       1049
Gly Ile Val Ser Lys Asp Glu Ile Thr Phe Val Ser Gly Ala Pro Arg           
            270                 275                 280                   

gcc aat cac agt gga gcc gtg gtt ttg ctg aag aga gac atg aag tct       1097
Ala Asn His Ser Gly Ala Val Val Leu Leu Lys Arg Asp Met Lys Ser           
        285                 290                 295                       

gca cat ctc ctc cct gag cac ata ttc gat gga gaa ggt ctg gcc tct       1145
Ala His Leu Leu Pro Glu His Ile Phe Asp Gly Glu Gly Leu Ala Ser           
    300                 305                 310                           

tca ttt ggc tat gat gtg gcg gtg gtg gac ctc aac aag gat ggg tgg       1193
Ser Phe Gly Tyr Asp Val Ala Val Val Asp Leu Asn Lys Asp Gly Trp           
315                 320                 325                 330           

caa gat ata gtt att gga gcc cca cag tat ttt gat aga gat gga gaa       1241
Gln Asp Ile Val Ile Gly Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu           
                335                 340                 345               

gtt gga ggt gca gtg tat gtc tac atg aac cag caa ggc aga tgg aat       1289
Val Gly Gly Ala Val Tyr Val Tyr Met Asn Gln Gln Gly Arg Trp Asn           
            350                 355                 360                   

aat gtg aag cca att cgt ctt aat gga acc aaa gat tct atg ttt ggc       1337
Asn Val Lys Pro Ile Arg Leu Asn Gly Thr Lys Asp Ser Met Phe Gly           
        365                 370                 375                       

att gca gta aaa aat att gga gat att aat caa gat ggc tac cca gat       1385
Ile Ala Val Lys Asn Ile Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp           
    380                 385                 390                           

att gca gtt gga gct ccg tat gat gac ttg gga aag gtt ttt atc tat       1433
Ile Ala Val Gly Ala Pro Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr           
395                 400                 405                 410           

cat gga tct gca aat gga ata aat acc aaa cca aca cag gtt ctc aag       1481
His Gly Ser Ala Asn Gly Ile Asn Thr Lys Pro Thr Gln Val Leu Lys           
                415                 420                 425               

ggt ata tca cct tat ttt gga tat tca att gct gga aac atg gac ctt       1529
Gly Ile Ser Pro Tyr Phe Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu           
            430                 435                 440                   

gat cga aat tcc tac cct gat gtt gct gtt ggt tcc ctc tca gat tca       1577
Asp Arg Asn Ser Tyr Pro Asp Val Ala Val Gly Ser Leu Ser Asp Ser           
        445                 450                 455                       

gta act att ttc aga tcc cgg cct gtg att aat att cag aaa acc atc       1625
Val Thr Ile Phe Arg Ser Arg Pro Val Ile Asn Ile Gln Lys Thr Ile           
    460                 465                 470                           

aca gta act cct aac aga att gac ctc cgc cag aaa aca gcg tgt ggg       1673
Thr Val Thr Pro Asn Arg Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly           
475                 480                 485                 490           

gcg cct agt ggg ata tgc ctc cag gtt aaa tcc tgt ttt gaa tat act       1721
Ala Pro Ser Gly Ile Cys Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr           
                495                 500                 505               

gct aac ccc gct ggt tat aat cct tca ata tca att gtg ggc aca ctt       1769
Ala Asn Pro Ala Gly Tyr Asn Pro Ser Ile Ser Ile Val Gly Thr Leu           
            510                 515                 520                   

gaa gct gaa aaa gaa aga aga aaa tct ggg cta tcc tca aga gtt cag       1817
Glu Ala Glu Lys Glu Arg Arg Lys Ser Gly Leu Ser Ser Arg Val Gln           
        525                 530                 535                       

ttt cga aac caa ggt tct gag ccc aaa tat act caa gaa cta act ctg       1865
Phe Arg Asn Gln Gly Ser Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu           
    540                 545                 550                           

aag agg cag aaa cag aaa gtg tgc atg gag gaa acc ctg tgg cta cag       1913
Lys Arg Gln Lys Gln Lys Val Cys Met Glu Glu Thr Leu Trp Leu Gln           
555                 560                 565                 570           

gat aat atc aga gat aaa ctg cgt ccc att ccc ata act gcc tca gtg       1961
Asp Asn Ile Arg Asp Lys Leu Arg Pro Ile Pro Ile Thr Ala Ser Val           
                575                 580                 585               

gag atc caa gag cca agc tct cgt agg cga gtg aat tca ctt cca gaa       2009
Glu Ile Gln Glu Pro Ser Ser Arg Arg Arg Val Asn Ser Leu Pro Glu           
            590                 595                 600                   

gtt ctt cca att ctg aat tca gat gaa ccc aag aca gct cat att gat       2057
Val Leu Pro Ile Leu Asn Ser Asp Glu Pro Lys Thr Ala His Ile Asp           
        605                 610                 615                       

gtt cac ttc tta aaa gag gga tgt gga gac gac aat gta tgt aac agc       2105
Val His Phe Leu Lys Glu Gly Cys Gly Asp Asp Asn Val Cys Asn Ser           
    620                 625                 630                           

aac ctt aaa cta gaa tat aaa ttt tgc acc cga gaa gga aat caa gac       2153
Asn Leu Lys Leu Glu Tyr Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp           
635                 640                 645                 650           

aaa ttt tct tat tta cca att caa aaa ggt gta cca gaa cta gtt cta       2201
Lys Phe Ser Tyr Leu Pro Ile Gln Lys Gly Val Pro Glu Leu Val Leu           
                655                 660                 665               

aaa gat cag aag gat att gct tta gaa ata aca gtg aca aac agc cct       2249
Lys Asp Gln Lys Asp Ile Ala Leu Glu Ile Thr Val Thr Asn Ser Pro           
            670                 675                 680                   

tcc aac cca agg aat ccc aca aaa gat ggc gat gac gcc cat gag gct       2297
Ser Asn Pro Arg Asn Pro Thr Lys Asp Gly Asp Asp Ala His Glu Ala           
        685                 690                 695                       

aaa ctg att gca acg ttt cca gac act tta acc tat tct gca tat aga       2345
Lys Leu Ile Ala Thr Phe Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg           
    700                 705                 710                           

gaa ctg agg gct ttc cct gag aaa cag ttg agt tgt gtt gcc aac cag       2393
Glu Leu Arg Ala Phe Pro Glu Lys Gln Leu Ser Cys Val Ala Asn Gln           
715                 720                 725                 730           

aat ggc tcg caa gct gac tgt gag ctc gga aat cct ttt aaa aga aat       2441
Asn Gly Ser Gln Ala Asp Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn           
                735                 740                 745               

tca aat gtc act ttt tat ttg gtt tta agt aca act gaa gtc acc ttt       2489
Ser Asn Val Thr Phe Tyr Leu Val Leu Ser Thr Thr Glu Val Thr Phe           
            750                 755                 760                   

gac acc cca gat ctg gat att aat ctg aag tta gaa aca aca agc aat       2537
Asp Thr Pro Asp Leu Asp Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn           
        765                 770                 775                       

caa gat aat ttg gct cca att aca gct aaa gca aaa gtg gtt att gaa       2585
Gln Asp Asn Leu Ala Pro Ile Thr Ala Lys Ala Lys Val Val Ile Glu           
    780                 785                 790                           

ctg ctt tta tcg gtc tcg gga gtt gct aaa cct tcc cag gtg tat ttt       2633
Leu Leu Leu Ser Val Ser Gly Val Ala Lys Pro Ser Gln Val Tyr Phe           
795                 800                 805                 810           

gga ggt aca gtt gtt ggc gag caa gct atg aaa tct gaa gat gaa gtg       2681
Gly Gly Thr Val Val Gly Glu Gln Ala Met Lys Ser Glu Asp Glu Val           
                815                 820                 825               

gga agt tta ata gag tat gaa ttc agg gta ata aac tta ggt aaa cct       2729
Gly Ser Leu Ile Glu Tyr Glu Phe Arg Val Ile Asn Leu Gly Lys Pro           
            830                 835                 840                   

ctt aca aac ctc ggc aca gca acc ttg aac att cag tgg cca aaa gaa       2777
Leu Thr Asn Leu Gly Thr Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu           
        845                 850                 855                       

att agc aat ggg aaa tgg ttg ctt tat ttg gtg aaa gta gaa tcc aaa       2825
Ile Ser Asn Gly Lys Trp Leu Leu Tyr Leu Val Lys Val Glu Ser Lys           
    860                 865                 870                           

gga ttg gaa aag gta act tgt gag cca caa aag gag ata aac tcc ctg       2873
Gly Leu Glu Lys Val Thr Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu           
875                 880                 885                 890           

aac cta acg gag tct cac aac tca aga aag aaa cgg gaa att act gaa       2921
Asn Leu Thr Glu Ser His Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu           
                895                 900                 905               

aaa cag ata gat gat aac aga aaa ttt tct tta ttt gct gaa aga aaa       2969
Lys Gln Ile Asp Asp Asn Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys           
            910                 915                 920                   

tac cag act ctt aac tgt agc gtg aac gtg aac tgt gtg aac atc aga       3017
Tyr Gln Thr Leu Asn Cys Ser Val Asn Val Asn Cys Val Asn Ile Arg           
        925                 930                 935                       

tgc ccg ctg cgg ggg ctg gac agc aag gcg tct ctt att ttg cgc tcg       3065
Cys Pro Leu Arg Gly Leu Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser           
    940                 945                 950                           

agg tta tgg aac agc aca ttt cta gag gaa tat tcc aaa ctg aac tac       3113
Arg Leu Trp Asn Ser Thr Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr           
955                 960                 965                 970           

ttg gac att ctc atg cga gcc ttc att gat gtg act gct gct gcc gaa       3161
Leu Asp Ile Leu Met Arg Ala Phe Ile Asp Val Thr Ala Ala Ala Glu           
                975                 980                 985               

aat atc agg ctg cca aat gca ggc act cag gtt cga gtg act  gtg ttt      3209
Asn Ile Arg Leu Pro Asn Ala Gly Thr Gln Val Arg Val Thr  Val Phe          
            990                 995                 1000                  

ccc tca aag  act gta gct cag tat  tcg gga gta cct tgg  tgg atc        3254
Pro Ser Lys  Thr Val Ala Gln Tyr  Ser Gly Val Pro Trp  Trp Ile            
        1005                 1010                 1015                    

atc cta gtg  gct att ctc gct ggg  atc ttg atg ctt gct  tta tta        3299
Ile Leu Val  Ala Ile Leu Ala Gly  Ile Leu Met Leu Ala  Leu Leu            
        1020                 1025                 1030                    

gtg ttt ata  cta tgg aag tgt gga  ttc ttt aaa cgc tct  agg tac        3344
Val Phe Ile  Leu Trp Lys Cys Gly  Phe Phe Lys Arg Ser  Arg Tyr            
        1035                 1040                 1045                    

gat gac agt  gtt ccc cga tac cat  gct gta agg atc cgg  aaa gaa        3389
Asp Asp Ser  Val Pro Arg Tyr His  Ala Val Arg Ile Arg  Lys Glu            
        1050                 1055                 1060                    

gag cga gag  atc aaa gat gaa aag  tat att gat aac ctt  gaa aaa        3434
Glu Arg Glu  Ile Lys Asp Glu Lys  Tyr Ile Asp Asn Leu  Glu Lys            
        1065                 1070                 1075                    

aaa cag tgg  atc aca aag tgg aac  gaa aat gaa agc tac  tca tag        3479
Lys Gln Trp  Ile Thr Lys Trp Asn  Glu Asn Glu Ser Tyr  Ser                
        1080                 1085                 1090                    

cgggggccta aaaaaaaaaa gcttcacagt acccaaactg ctttttccaa ctcagaaatt     3539

caatttggat ttaaaagcct gctcaatccc tgaggactga tttcagagtg actacacaca     3599

gtacgaacct acagttttaa ctgtggatat tgttacgtag cctaaggctc ctgttttgca     3659

cagccaaatt taaaactgtt ggaatggatt tttctttaac tgccgtaatt taactttctg     3719

ggttgccttt atttttggcg tggctgactt acatcatgtg ttggggaagg gcctgcccag     3779

ttgcactcag gtgacatcct ccagatagtg tagctgagga ggcacctaca ctcacctgca     3839

ctaacagagt ggccgtccta acctcgggcc tgctgcgcag acgtccatca cgttagctgt     3899

cccacatcac aagactatgc cattggggta gttgtgtttc aacggaaagt gctgtcttaa     3959

actaaatgtg caatagaagg tgatgttgcc atcctaccgt cttttcctgt ttcctagctg     4019

tgtgaatacc tgctcacgtc aaatgcatac aagtttcatt ctccctttca ctaaaacaca     4079

caggtgcaac agacttgaat gctagttata cttatttgta tatggtattt attttttctt     4139

ttctttacaa accattttgt tattgactaa caggccaaag agtctccagt ttacccttca     4199

ggttggttta atcaatcaga attagagcat gggaggtcat cactttgacc taaattattt     4259

actgcaaaaa gaaaatcttt ataaatgtac cagagagagt tgttttaata acttatctat     4319

aaactataac ctctccttca tgacagcctc caccccacaa cccaaaaggt ttaagaaata     4379

gaattataac tgtaaagatg tttatttcag gcattggata ttttttactt tagaagcctg     4439

cataatgttt ctggatttca tactgtaaca ttcaggaatt cttggagaaa atgggtttat     4499

tcactgaact ctagtgcggt ttactcactg ctgcaaatac tgtatattca ggacttgaaa     4559

gaaatggtga atgcctatgg tggatccaaa ctgatccagt ataagactac tgaatctgct     4619

accaaaacag ttaatcagtg agtcgatgtt ctattttttg ttttgtttcc tcccctatct     4679

gtattcccaa aaattacttt ggggctaatt taacaagaac tttaaattgt gttttaattg     4739

taaaaatggc agggggtgga attattactc tatacattca acagagactg aatagatatg     4799

aaagctgatt ttttttaatt accatgcttc acaatgttaa gttatatggg gagcaacagc     4859

aaacaggtgc taatttgttt tggatatagt ataagcagtg tctgtgtttt gaaagaatag     4919

aacacagttt gtagtgccac tgttgttttg ggggggcttt tttcttttcg gaaatcttaa     4979

accttaagat actaaggacg ttgttttggt tgtactttgg aattcttagt cacaaaatat     5039

attttgttta caaaaatttc tgtaaaacag gttataacag tgtttaaagt ctcagtttct     5099

tgcttgggga acttgtgtcc ctaatgtgtt tagattgcta gattgctaag gagctgatac     5159

tttgacagtg tttttagacc tgtgttacta aaaaaaagat gaatgtcctg aaaagggtgt     5219

tgggagggtg gttcaacaaa gaaacaaaga tgttatggtg tttagattta tggttgttaa     5279

aaatgtcatc tcaagtcaag tcactggtct gtttgcattt gatacatttt tgtactaact     5339

agcattgtaa aattatttca tgattagaaa ttacctgtgg atatttgtat aaaagtgtga     5399

aataaatttt ttataaaagt gttcattgtt tcgtaacaca gcattgtata tgtgaagcaa     5459

actctaaaat tataaatgac aacctgaatt atctatttca tcaaaccaaa gttcagtgtt     5519

tttatttttg gtgtctcatg taatctcaga tcagccaaag atactagtgc caaagcaatg     5579

ggattcgggg tttttttctg ttttcgctct atgtaggtga tcctcaagtc tttcattttc     5639

cttctttatg attaaaagaa acctacaggt atttaacaac c                         5680


<210>  222
<211>  1091
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu 
1               5                   10                  15      


Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn 
            20                  25                  30          


Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu 
        35                  40                  45              


Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val 
    50                  55                  60                  


Gly Ala Pro Arg Ala Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr 
65                  70                  75                  80  


Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg 
                85                  90                  95      


Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp 
            100                 105                 110         


Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val 
        115                 120                 125             


Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys 
    130                 135                 140                 


Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp 
                165                 170                 175     


Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val 
            180                 185                 190         


Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro 
        195                 200                 205             


Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn 
    210                 215                 220                 


Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly 
225                 230                 235                 240 


Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser 
                245                 250                 255     


Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp 
            260                 265                 270         


Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala 
        275                 280                 285             


Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu 
    290                 295                 300                 


His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val 
305                 310                 315                 320 


Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly 
                325                 330                 335     


Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr 
            340                 345                 350         


Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg 
        355                 360                 365             


Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile 
    370                 375                 380                 


Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro 
385                 390                 395                 400 


Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly 
                405                 410                 415     


Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe 
            420                 425                 430         


Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro 
        435                 440                 445             


Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser 
    450                 455                 460                 


Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg 
465                 470                 475                 480 


Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys 
                485                 490                 495     


Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr 
            500                 505                 510         


Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg 
        515                 520                 525             


Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser 
    530                 535                 540                 


Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys 
545                 550                 555                 560 


Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys 
                565                 570                 575     


Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser 
            580                 585                 590         


Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn 
        595                 600                 605             


Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu 
    610                 615                 620                 


Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr 
625                 630                 635                 640 


Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro 
                645                 650                 655     


Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile 
            660                 665                 670         


Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro 
        675                 680                 685             


Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe 
    690                 695                 700                 


Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro 
705                 710                 715                 720 


Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp 
                725                 730                 735     


Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr 
            740                 745                 750         


Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Asp Leu Asp 
        755                 760                 765             


Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro 
    770                 775                 780                 


Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser 
785                 790                 795                 800 


Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly 
                805                 810                 815     


Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr 
            820                 825                 830         


Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr 
        835                 840                 845             


Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp 
    850                 855                 860                 


Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr 
865                 870                 875                 880 


Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His 
                885                 890                 895     


Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn 
            900                 905                 910         


Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys 
        915                 920                 925             


Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu 
    930                 935                 940                 


Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr 
945                 950                 955                 960 


Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg 
                965                 970                 975     


Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn 
            980                 985                 990         


Ala Gly Thr Gln Val Arg Val Thr  Val Phe Pro Ser Lys  Thr Val Ala 
        995                 1000                 1005             


Gln Tyr  Ser Gly Val Pro Trp  Trp Ile Ile Leu Val  Ala Ile Leu 
    1010                 1015                 1020             


Ala Gly  Ile Leu Met Leu Ala  Leu Leu Val Phe Ile  Leu Trp Lys 
    1025                 1030                 1035             


Cys Gly  Phe Phe Lys Arg Ser  Arg Tyr Asp Asp Ser  Val Pro Arg 
    1040                 1045                 1050             


Tyr His  Ala Val Arg Ile Arg  Lys Glu Glu Arg Glu  Ile Lys Asp 
    1055                 1060                 1065             


Glu Lys  Tyr Ile Asp Asn Leu  Glu Lys Lys Gln Trp  Ile Thr Lys 
    1070                 1075                 1080             


Trp Asn  Glu Asn Glu Ser Tyr  Ser 
    1085                 1090     


<210>  223
<211>  303
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(303)

<400>  223
atg cgc cca att gtg gtc aag acc aag aaa ctg aga aac aaa gca aat         48
Met Arg Pro Ile Val Val Lys Thr Lys Lys Leu Arg Asn Lys Ala Asn           
1               5                   10                  15                

ccg tgg gat gca gag ggt acg ctg atg act tct gct ggg gag aga agc         96
Pro Trp Asp Ala Glu Gly Thr Leu Met Thr Ser Ala Gly Glu Arg Ser           
            20                  25                  30                    

cca aac aca cgt cct ggg cag agc cca gag acc ggg agt gtg gct gcc        144
Pro Asn Thr Arg Pro Gly Gln Ser Pro Glu Thr Gly Ser Val Ala Ala           
        35                  40                  45                        

agt gag cac ccg gct gag gga caa gca ggt ggg cct cag tgg tgg ctg        192
Ser Glu His Pro Ala Glu Gly Gln Ala Gly Gly Pro Gln Trp Trp Leu           
    50                  55                  60                            

cca ggt ccc tgg aag ccg ggg gcc acc ggc ctt gcc tct cct ctg cct        240
Pro Gly Pro Trp Lys Pro Gly Ala Thr Gly Leu Ala Ser Pro Leu Pro           
65                  70                  75                  80            

cgg aag cac cgg agg ctt tgg gga tct ggt ggt cct ccg gcc ctg aac        288
Arg Lys His Arg Arg Leu Trp Gly Ser Gly Gly Pro Pro Ala Leu Asn           
                85                  90                  95                

gtg gac ctg gtg tga                                                    303
Val Asp Leu Val                                                           
            100                                                           


<210>  224
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Arg Pro Ile Val Val Lys Thr Lys Lys Leu Arg Asn Lys Ala Asn 
1               5                   10                  15      


Pro Trp Asp Ala Glu Gly Thr Leu Met Thr Ser Ala Gly Glu Arg Ser 
            20                  25                  30          


Pro Asn Thr Arg Pro Gly Gln Ser Pro Glu Thr Gly Ser Val Ala Ala 
        35                  40                  45              


Ser Glu His Pro Ala Glu Gly Gln Ala Gly Gly Pro Gln Trp Trp Leu 
    50                  55                  60                  


Pro Gly Pro Trp Lys Pro Gly Ala Thr Gly Leu Ala Ser Pro Leu Pro 
65                  70                  75                  80  


Arg Lys His Arg Arg Leu Trp Gly Ser Gly Gly Pro Pro Ala Leu Asn 
                85                  90                  95      


Val Asp Leu Val 
            100 


<210>  225
<211>  1455
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (148)..(888)

<400>  225
aagcaccgat aggctctgcc tcccgaagaa aagggagccg cgcagcgcct acgggagtcc       60

ggcggcagca gccggtaccg gcaaccacgg gcagctctca gggaatctcc gtcgtgaggc      120

cagaggctcc agtccccgcg agtccag atg cct gtc cag cct cca agc aaa gac      174
                              Met Pro Val Gln Pro Pro Ser Lys Asp         
                              1               5                           

aca gaa gag atg gaa gca gag ggt gat tct gct gct gag atg aat ggg        222
Thr Glu Glu Met Glu Ala Glu Gly Asp Ser Ala Ala Glu Met Asn Gly           
10                  15                  20                  25            

gag gag gaa gag agt gag gag gag cgg agc ggc agc cag aca gag tca        270
Glu Glu Glu Glu Ser Glu Glu Glu Arg Ser Gly Ser Gln Thr Glu Ser           
                30                  35                  40                

gaa gag gag agc tcc gag atg gat gat gag gac tat gag cga cgc cgc        318
Glu Glu Glu Ser Ser Glu Met Asp Asp Glu Asp Tyr Glu Arg Arg Arg           
            45                  50                  55                    

agc gag tgt gtc agt gag atg ctg gac cta gag aag cag ttc tcg gag        366
Ser Glu Cys Val Ser Glu Met Leu Asp Leu Glu Lys Gln Phe Ser Glu           
        60                  65                  70                        

cta aag gag aag ttg ttc agg gaa cga ctg agt cag ctg cgg ttg cgg        414
Leu Lys Glu Lys Leu Phe Arg Glu Arg Leu Ser Gln Leu Arg Leu Arg           
    75                  80                  85                            

ctg gag gaa gtg ggg gct gag aga gcc cct gaa tac acg gag ccc ctt        462
Leu Glu Glu Val Gly Ala Glu Arg Ala Pro Glu Tyr Thr Glu Pro Leu           
90                  95                  100                 105           

ggg ggg ctg cag cgg agc ctc aag att cgc att cag gtg gca ggg atc        510
Gly Gly Leu Gln Arg Ser Leu Lys Ile Arg Ile Gln Val Ala Gly Ile           
                110                 115                 120               

tac aag ggc ttc tgt ctg gat gtg atc agg aat aag tac gaa tgt gag        558
Tyr Lys Gly Phe Cys Leu Asp Val Ile Arg Asn Lys Tyr Glu Cys Glu           
            125                 130                 135                   

ctg cag gga gcc aaa cag cac ctg gag agt gag aag ctg ctg ctc tat        606
Leu Gln Gly Ala Lys Gln His Leu Glu Ser Glu Lys Leu Leu Leu Tyr           
        140                 145                 150                       

gac acg ctg cag ggg gag ctg cag gag cgg atc cag agg ctg gag gag        654
Asp Thr Leu Gln Gly Glu Leu Gln Glu Arg Ile Gln Arg Leu Glu Glu           
    155                 160                 165                           

gac cgc cag agc ctg gac ctc agc tct gaa tgg tgg gat gac aaa ctg        702
Asp Arg Gln Ser Leu Asp Leu Ser Ser Glu Trp Trp Asp Asp Lys Leu           
170                 175                 180                 185           

cac gcc aga ggc agc tcc agg tct tgg gac tcc ctg ccg ccc agc aag        750
His Ala Arg Gly Ser Ser Arg Ser Trp Asp Ser Leu Pro Pro Ser Lys           
                190                 195                 200               

agg aag aag gca cct ctg gtt tct ggc cca tac atc gtg tac atg ctt        798
Arg Lys Lys Ala Pro Leu Val Ser Gly Pro Tyr Ile Val Tyr Met Leu           
            205                 210                 215                   

caa gag atc gac atc ctg gag gac tgg aca gcc atc aaa aag gct agg        846
Gln Glu Ile Asp Ile Leu Glu Asp Trp Thr Ala Ile Lys Lys Ala Arg           
        220                 225                 230                       

gca gct gtg tcc cct cag aag aga aaa tcg gat gga cct tga                888
Ala Ala Val Ser Pro Gln Lys Arg Lys Ser Asp Gly Pro                       
    235                 240                 245                           

ccctgctgtt cacagccagg gggaccctca gagcagctgg cactgcaccc aggattctcg      948

tcttcctcct gcagacaggc ggacccacag gcccctcagg gtctgcccag ccaggctcct     1008

gtggtgctgc tgggccctcc cactccatct ggcactggcc tggactcctc ctctgccctc     1068

ctcgaggcct gcacagctgt ggccgtggag ctgacctgac caggcaaggc tgctgtctcc     1128

atccctgagc cgcctgccac ctcccactcc tgaagatcca tctcttgggg ctcccctgac     1188

agagaagaca gccgaagtca aagccacatc ctcttgctga tgttggatgc aggctgtccg     1248

gcctcagggc cagggagcca gtttccactg tgcgggaact ctgagtcaga cgtgattatc     1308

tgggggtctg tccaccctgg ctggatctgg aggcaagatg ccaggccccc caggtgttct     1368

cagggcagtt cttggtgtct gcttctcaga ttccaaggac tggaattaaa acctttcctg     1428

ggactctgga aaaaaaaaaa aaaaaaa                                         1455


<210>  226
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Pro Val Gln Pro Pro Ser Lys Asp Thr Glu Glu Met Glu Ala Glu 
1               5                   10                  15      


Gly Asp Ser Ala Ala Glu Met Asn Gly Glu Glu Glu Glu Ser Glu Glu 
            20                  25                  30          


Glu Arg Ser Gly Ser Gln Thr Glu Ser Glu Glu Glu Ser Ser Glu Met 
        35                  40                  45              


Asp Asp Glu Asp Tyr Glu Arg Arg Arg Ser Glu Cys Val Ser Glu Met 
    50                  55                  60                  


Leu Asp Leu Glu Lys Gln Phe Ser Glu Leu Lys Glu Lys Leu Phe Arg 
65                  70                  75                  80  


Glu Arg Leu Ser Gln Leu Arg Leu Arg Leu Glu Glu Val Gly Ala Glu 
                85                  90                  95      


Arg Ala Pro Glu Tyr Thr Glu Pro Leu Gly Gly Leu Gln Arg Ser Leu 
            100                 105                 110         


Lys Ile Arg Ile Gln Val Ala Gly Ile Tyr Lys Gly Phe Cys Leu Asp 
        115                 120                 125             


Val Ile Arg Asn Lys Tyr Glu Cys Glu Leu Gln Gly Ala Lys Gln His 
    130                 135                 140                 


Leu Glu Ser Glu Lys Leu Leu Leu Tyr Asp Thr Leu Gln Gly Glu Leu 
145                 150                 155                 160 


Gln Glu Arg Ile Gln Arg Leu Glu Glu Asp Arg Gln Ser Leu Asp Leu 
                165                 170                 175     


Ser Ser Glu Trp Trp Asp Asp Lys Leu His Ala Arg Gly Ser Ser Arg 
            180                 185                 190         


Ser Trp Asp Ser Leu Pro Pro Ser Lys Arg Lys Lys Ala Pro Leu Val 
        195                 200                 205             


Ser Gly Pro Tyr Ile Val Tyr Met Leu Gln Glu Ile Asp Ile Leu Glu 
    210                 215                 220                 


Asp Trp Thr Ala Ile Lys Lys Ala Arg Ala Ala Val Ser Pro Gln Lys 
225                 230                 235                 240 


Arg Lys Ser Asp Gly Pro 
                245     


<210>  227
<211>  1690
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (146)..(640)

<400>  227
tgctttctca aaggccccac agtcctccac ttcctgggga ggtagctgca gaataaaacc       60

agcagagact ccttttctcc taaccgtccc ggccaccgct gcctcagcct ctgcctccca      120

gcctctttct gagggaaagg acaag atg aag tgg aag gcg ctt ttc acc gcg        172
                            Met Lys Trp Lys Ala Leu Phe Thr Ala           
                            1               5                             

gcc atc ctg cag gca cag ttg ccg att aca gag gca cag agc ttt ggc        220
Ala Ile Leu Gln Ala Gln Leu Pro Ile Thr Glu Ala Gln Ser Phe Gly           
10                  15                  20                  25            

ctg ctg gat ccc aaa ctc tgc tac ctg ctg gat gga atc ctc ttc atc        268
Leu Leu Asp Pro Lys Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile           
                30                  35                  40                

tat ggt gtc att ctc act gcc ttg ttc ctg aga gtg aag ttc agc agg        316
Tyr Gly Val Ile Leu Thr Ala Leu Phe Leu Arg Val Lys Phe Ser Arg           
            45                  50                  55                    

agc gca gac gcc ccc gcg tac cag cag ggc cag aac cag ctc tat aac        364
Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn           
        60                  65                  70                        

gag ctc aat cta gga cga aga gag gag tac gat gtt ttg gac aag aga        412
Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg           
    75                  80                  85                            

cgt ggc cgg gac cct gag atg ggg gga aag ccg cag aga agg aag aac        460
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn           
90                  95                  100                 105           

cct cag gaa ggc ctg tac aat gaa ctg cag aaa gat aag atg gcg gag        508
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu           
                110                 115                 120               

gcc tac agt gag att ggg atg aaa ggc gag cgc cgg agg ggc aag ggg        556
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly           
            125                 130                 135                   

cac gat ggc ctt tac cag ggt ctc agt aca gcc acc aag gac acc tac        604
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr           
        140                 145                 150                       

gac gcc ctt cac atg cag gcc ctg ccc cct cgc taa cagccagggg             650
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg                               
    155                 160                                               

atttcaccac tcaaaggcca gacctgcaga cgcccagatt atgagacaca ggatgaagca      710

tttacaaccc ggttcactct tctcagccac tgaagtattc ccctttatgt acaggatgct      770

ttggttatat ttagctccaa accttcacac acagactgtt gtccctgcac tctttaaggg      830

agtgtactcc cagggcttac ggccctggcc ttgggccctc tggtttgccg gtggtgcagg      890

tagacctgtc tcctggcggt tcctcgttct ccctgggagg cgggcgcact gcctctcaca      950

gctgagttgt tgagtctgtt ttgtaaagtc cccagagaaa gcgcagatgc tagcacatgc     1010

cctaatgtct gtatcactct gtgtctgagt ggcttcactc ctgctgtaaa tttggcttct     1070

gttgtcacct tcacctcctt tcaaggtaac tgtactgggc catgttgtgc ctccctggtg     1130

agagggccgg gcagaggggc agatggaaag gagcctaggc caggtgcaac cagggagctg     1190

caggggcatg ggaaggtggg cgggcagggg agggtcagcc agggcctgcg agggcagcgg     1250

gagcctccct gcctcaggcc tctgtgccgc accattgaac tgtaccatgt gctacagggg     1310

ccagaagatg aacagactga ccttgatgag ctgtgcacaa agtggcataa aaaacatgtg     1370

gttacacagt gtgaataaag tgctgcggag caagaggagg ccgttgattc acttcacgct     1430

ttcagcgaat gacaaaatca tctttgtgaa ggcctcgcag gaagacccaa cacatgggac     1490

ctataactgc ccagcggaca gtggcaggac aggaaaaacc cgtcaatgta ctaggatact     1550

gctgcgtcat tacagggcac aggccatgga tggaaaacgc tctctgctct gctttttttc     1610

tactgtttta atttatactg gcatgctaaa gccttcctat tttgcataat aaatgcttca     1670

gtgaaaatgc aaaaaaaaaa                                                 1690


<210>  228
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  229
<211>  1057
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (11)..(952)

<400>  229
accagaagag atg gag ctg gac aga gct gtg ggg gtc ctg ggc gct gcc          49
           Met Glu Leu Asp Arg Ala Val Gly Val Leu Gly Ala Ala            
           1               5                   10                         

acc ctg ctg ctc tct ttc ctg ggc atg gcc tgg gct ctc cag gcg gca         97
Thr Leu Leu Leu Ser Phe Leu Gly Met Ala Trp Ala Leu Gln Ala Ala           
    15                  20                  25                            

gac acc tgt cca gag gtg aag atg gtg ggc ctg gag ggc tct gac aag        145
Asp Thr Cys Pro Glu Val Lys Met Val Gly Leu Glu Gly Ser Asp Lys           
30                  35                  40                  45            

ctc acc att ctc cga ggc tgt ccg ggg ctg cct ggg gcc cct ggg ccc        193
Leu Thr Ile Leu Arg Gly Cys Pro Gly Leu Pro Gly Ala Pro Gly Pro           
                50                  55                  60                

aag gga gag gca ggc acc aat gga aag aga gga gaa cgt ggc ccc cct        241
Lys Gly Glu Ala Gly Thr Asn Gly Lys Arg Gly Glu Arg Gly Pro Pro           
            65                  70                  75                    

gga cct cct ggg aag gca gga cca cct ggg ccc aac gga gca cct ggg        289
Gly Pro Pro Gly Lys Ala Gly Pro Pro Gly Pro Asn Gly Ala Pro Gly           
        80                  85                  90                        

gag ccc cag ccg tgc ctg aca ggc ccg cgt acc tgc aag gac ctg cta        337
Glu Pro Gln Pro Cys Leu Thr Gly Pro Arg Thr Cys Lys Asp Leu Leu           
    95                  100                 105                           

gac cga ggg cac ttc ctg agc ggc tgg cac acc atc tac ctg ccc gac        385
Asp Arg Gly His Phe Leu Ser Gly Trp His Thr Ile Tyr Leu Pro Asp           
110                 115                 120                 125           

tgc cgg ccc ctg act gtg ctc tgt gac atg gac acg gac gga ggg ggc        433
Cys Arg Pro Leu Thr Val Leu Cys Asp Met Asp Thr Asp Gly Gly Gly           
                130                 135                 140               

tgg acc gtt ttc cag cgg agg gtg gat ggc tct gtg gac ttc tac cgg        481
Trp Thr Val Phe Gln Arg Arg Val Asp Gly Ser Val Asp Phe Tyr Arg           
            145                 150                 155                   

gac tgg gcc acg tac aag cag ggc ttc ggc agt cgg ctg ggg gag ttc        529
Asp Trp Ala Thr Tyr Lys Gln Gly Phe Gly Ser Arg Leu Gly Glu Phe           
        160                 165                 170                       

tgg ctg ggg aat gac aac atc cac gcc ctg acc gcc cag gga acc agc        577
Trp Leu Gly Asn Asp Asn Ile His Ala Leu Thr Ala Gln Gly Thr Ser           
    175                 180                 185                           

gag ctc cgt gta gac ctg gtg gac ttt gag gac aac tac cag ttt gct        625
Glu Leu Arg Val Asp Leu Val Asp Phe Glu Asp Asn Tyr Gln Phe Ala           
190                 195                 200                 205           

aag tac aga tca ttc aag gtg gcc gac gag gcg gag aag tac aat ctg        673
Lys Tyr Arg Ser Phe Lys Val Ala Asp Glu Ala Glu Lys Tyr Asn Leu           
                210                 215                 220               

gtc ctg ggg gcc ttc gtg gag ggc agt gcg gga gat tcc ctg acg ttc        721
Val Leu Gly Ala Phe Val Glu Gly Ser Ala Gly Asp Ser Leu Thr Phe           
            225                 230                 235                   

cac aac aac cag tcc ttc tcc acc aaa gac cag gac aat gat ctt aac        769
His Asn Asn Gln Ser Phe Ser Thr Lys Asp Gln Asp Asn Asp Leu Asn           
        240                 245                 250                       

acc gga aat tgt gct gtg atg ttt cag gga gct tgg tgg tac aaa aac        817
Thr Gly Asn Cys Ala Val Met Phe Gln Gly Ala Trp Trp Tyr Lys Asn           
    255                 260                 265                           

tgc cat gtg tca aac ctg aat ggt cgc tac ctc agg ggg act cat ggc        865
Cys His Val Ser Asn Leu Asn Gly Arg Tyr Leu Arg Gly Thr His Gly           
270                 275                 280                 285           

agc ttt gca aat ggc atc aac tgg aag tcg ggg aaa gga tac aat tat        913
Ser Phe Ala Asn Gly Ile Asn Trp Lys Ser Gly Lys Gly Tyr Asn Tyr           
                290                 295                 300               

agc tac aag gtg tca gag atg aag gtg cga cct gcc tag cccaggccgg         962
Ser Tyr Lys Val Ser Glu Met Lys Val Arg Pro Ala                           
            305                 310                                       

cctcagggtc aggacgcctc cacacatagt tggttggggg gtagggttgg gagcttggcc     1022

ctacggtttg taaaagaaac acatgtcgtg attct                                1057


<210>  230
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Glu Leu Asp Arg Ala Val Gly Val Leu Gly Ala Ala Thr Leu Leu 
1               5                   10                  15      


Leu Ser Phe Leu Gly Met Ala Trp Ala Leu Gln Ala Ala Asp Thr Cys 
            20                  25                  30          


Pro Glu Val Lys Met Val Gly Leu Glu Gly Ser Asp Lys Leu Thr Ile 
        35                  40                  45              


Leu Arg Gly Cys Pro Gly Leu Pro Gly Ala Pro Gly Pro Lys Gly Glu 
    50                  55                  60                  


Ala Gly Thr Asn Gly Lys Arg Gly Glu Arg Gly Pro Pro Gly Pro Pro 
65                  70                  75                  80  


Gly Lys Ala Gly Pro Pro Gly Pro Asn Gly Ala Pro Gly Glu Pro Gln 
                85                  90                  95      


Pro Cys Leu Thr Gly Pro Arg Thr Cys Lys Asp Leu Leu Asp Arg Gly 
            100                 105                 110         


His Phe Leu Ser Gly Trp His Thr Ile Tyr Leu Pro Asp Cys Arg Pro 
        115                 120                 125             


Leu Thr Val Leu Cys Asp Met Asp Thr Asp Gly Gly Gly Trp Thr Val 
    130                 135                 140                 


Phe Gln Arg Arg Val Asp Gly Ser Val Asp Phe Tyr Arg Asp Trp Ala 
145                 150                 155                 160 


Thr Tyr Lys Gln Gly Phe Gly Ser Arg Leu Gly Glu Phe Trp Leu Gly 
                165                 170                 175     


Asn Asp Asn Ile His Ala Leu Thr Ala Gln Gly Thr Ser Glu Leu Arg 
            180                 185                 190         


Val Asp Leu Val Asp Phe Glu Asp Asn Tyr Gln Phe Ala Lys Tyr Arg 
        195                 200                 205             


Ser Phe Lys Val Ala Asp Glu Ala Glu Lys Tyr Asn Leu Val Leu Gly 
    210                 215                 220                 


Ala Phe Val Glu Gly Ser Ala Gly Asp Ser Leu Thr Phe His Asn Asn 
225                 230                 235                 240 


Gln Ser Phe Ser Thr Lys Asp Gln Asp Asn Asp Leu Asn Thr Gly Asn 
                245                 250                 255     


Cys Ala Val Met Phe Gln Gly Ala Trp Trp Tyr Lys Asn Cys His Val 
            260                 265                 270         


Ser Asn Leu Asn Gly Arg Tyr Leu Arg Gly Thr His Gly Ser Phe Ala 
        275                 280                 285             


Asn Gly Ile Asn Trp Lys Ser Gly Lys Gly Tyr Asn Tyr Ser Tyr Lys 
    290                 295                 300                 


Val Ser Glu Met Lys Val Arg Pro Ala 
305                 310             


<210>  231
<211>  2448
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (141)..(2012)

<400>  231
gtcaccgccg aatggcagcc tccagaaagc caccgcgagt aagggtgaat caccaggatt       60

ttcaactgag aaatttaaga ataattgaac ctaacgaggt gacacactca ggagacacag      120

gtgtggaaac agacggcaga atg cct cca aag gtg act tca gag ctg ctt cgg      173
                      Met Pro Pro Lys Val Thr Ser Glu Leu Leu Arg         
                      1               5                   10              

cag ctg aga caa gcc atg agg aac tct gag tat gtg acc gaa ccg atc        221
Gln Leu Arg Gln Ala Met Arg Asn Ser Glu Tyr Val Thr Glu Pro Ile           
            15                  20                  25                    

cag gcc tac atc atc cca tcg gga gat gct cat cag agt gag tat att        269
Gln Ala Tyr Ile Ile Pro Ser Gly Asp Ala His Gln Ser Glu Tyr Ile           
        30                  35                  40                        

gct cca tgt gac tgt cgg cgg gct ttt gtc tct gga ttc gat ggc tct        317
Ala Pro Cys Asp Cys Arg Arg Ala Phe Val Ser Gly Phe Asp Gly Ser           
    45                  50                  55                            

gcg ggc aca gcc atc atc aca gaa gag cat gca gcc atg tgg act gac        365
Ala Gly Thr Ala Ile Ile Thr Glu Glu His Ala Ala Met Trp Thr Asp           
60                  65                  70                  75            

ggg cgc tac ttt ctc cag gct gcc aag caa atg gac agc aac tgg aca        413
Gly Arg Tyr Phe Leu Gln Ala Ala Lys Gln Met Asp Ser Asn Trp Thr           
                80                  85                  90                

ctt atg aag atg ggt ctg aag gac aca cca act cag gaa gac tgg ctg        461
Leu Met Lys Met Gly Leu Lys Asp Thr Pro Thr Gln Glu Asp Trp Leu           
            95                  100                 105                   

gtg agt gtg ctt cct gaa gga tcc agg gtt ggt gtg gac ccc ttg atc        509
Val Ser Val Leu Pro Glu Gly Ser Arg Val Gly Val Asp Pro Leu Ile           
        110                 115                 120                       

att cct aca gat tat tgg aag aaa atg gcc aaa gtt ctg aga agt gcc        557
Ile Pro Thr Asp Tyr Trp Lys Lys Met Ala Lys Val Leu Arg Ser Ala           
    125                 130                 135                           

ggc cat cac ctc att cct gtc aag gag aac ctc gtt gac aaa atc tgg        605
Gly His His Leu Ile Pro Val Lys Glu Asn Leu Val Asp Lys Ile Trp           
140                 145                 150                 155           

aca gac cgt cct gag cgc cct tgc aag cct ctc ctc aca ctg ggc ctg        653
Thr Asp Arg Pro Glu Arg Pro Cys Lys Pro Leu Leu Thr Leu Gly Leu           
                160                 165                 170               

gat tac aca ggc atc tcc tgg aag gac aag gtt gca gac ctt cgg ttg        701
Asp Tyr Thr Gly Ile Ser Trp Lys Asp Lys Val Ala Asp Leu Arg Leu           
            175                 180                 185                   

aaa atg gct gag agg aac gtc atg tgg ttt gtg gtc act gcc ttg gat        749
Lys Met Ala Glu Arg Asn Val Met Trp Phe Val Val Thr Ala Leu Asp           
        190                 195                 200                       

gag att gcg tgg cta ttt aat ctc cga gga tca gat gtg gag cac aat        797
Glu Ile Ala Trp Leu Phe Asn Leu Arg Gly Ser Asp Val Glu His Asn           
    205                 210                 215                           

cca gta ttt ttc tcc tac gca atc ata gga cta gag acg atc atg ctc        845
Pro Val Phe Phe Ser Tyr Ala Ile Ile Gly Leu Glu Thr Ile Met Leu           
220                 225                 230                 235           

ttc att gat ggt gac cgc ata gac gcc ccc agt gtg aag gag cac ctg        893
Phe Ile Asp Gly Asp Arg Ile Asp Ala Pro Ser Val Lys Glu His Leu           
                240                 245                 250               

ctt ctt gac ttg ggt ctg gaa gcc gaa tac agg atc cag gtg cat ccc        941
Leu Leu Asp Leu Gly Leu Glu Ala Glu Tyr Arg Ile Gln Val His Pro           
            255                 260                 265                   

tac aag tcc atc ctg agc gag ctc aag gcc ctg tgt gct gac ctc tcc        989
Tyr Lys Ser Ile Leu Ser Glu Leu Lys Ala Leu Cys Ala Asp Leu Ser           
        270                 275                 280                       

cca agg gag aag gtg tgg gtc agt gac aag gcc agc tat gct gtg agc       1037
Pro Arg Glu Lys Val Trp Val Ser Asp Lys Ala Ser Tyr Ala Val Ser           
    285                 290                 295                           

gag acc atc ccc aag gac cac cgc tgc tgt atg cct tac acc ccc atc       1085
Glu Thr Ile Pro Lys Asp His Arg Cys Cys Met Pro Tyr Thr Pro Ile           
300                 305                 310                 315           

tgc atc gcc aaa gct gtg aag aat tca gct gag tca gaa ggc atg agg       1133
Cys Ile Ala Lys Ala Val Lys Asn Ser Ala Glu Ser Glu Gly Met Arg           
                320                 325                 330               

cgg gct cac att aaa gat gct gtt gct ctc tgt gaa ctc ttt aac tgg       1181
Arg Ala His Ile Lys Asp Ala Val Ala Leu Cys Glu Leu Phe Asn Trp           
            335                 340                 345                   

ctg gag aaa gag gtt ccc aaa ggt ggt gtg aca gag atc tca gct gct       1229
Leu Glu Lys Glu Val Pro Lys Gly Gly Val Thr Glu Ile Ser Ala Ala           
        350                 355                 360                       

gac aaa gct gag gag ttt cgc agg caa cag gca gac ttt gtg gac ctg       1277
Asp Lys Ala Glu Glu Phe Arg Arg Gln Gln Ala Asp Phe Val Asp Leu           
    365                 370                 375                           

agc ttc cca aca att tcc agt acg gga ccc aac ggc gcc atc att cac       1325
Ser Phe Pro Thr Ile Ser Ser Thr Gly Pro Asn Gly Ala Ile Ile His           
380                 385                 390                 395           

tac gcg cca gtc cct gag acg aat agg acc ttg tcc ctg gat gag gtg       1373
Tyr Ala Pro Val Pro Glu Thr Asn Arg Thr Leu Ser Leu Asp Glu Val           
                400                 405                 410               

tac ctt att gac tcg ggt gct caa tac aag gat ggc acc aca gat gtg       1421
Tyr Leu Ile Asp Ser Gly Ala Gln Tyr Lys Asp Gly Thr Thr Asp Val           
            415                 420                 425                   

acg cgg aca atg cat ttt ggg acc cct aca gcc tac gag aag gaa tgc       1469
Thr Arg Thr Met His Phe Gly Thr Pro Thr Ala Tyr Glu Lys Glu Cys           
        430                 435                 440                       

ttc aca tat gtc ctc aag ggc cac ata gct gtg agt gca gcc gtt ttc       1517
Phe Thr Tyr Val Leu Lys Gly His Ile Ala Val Ser Ala Ala Val Phe           
    445                 450                 455                           

ccg act gga acc aaa ggt cac ctt ctt gac tcc ttt gcc cgt tca gct       1565
Pro Thr Gly Thr Lys Gly His Leu Leu Asp Ser Phe Ala Arg Ser Ala           
460                 465                 470                 475           

tta tgg gat tca ggc cta gat tac ttg cac ggg act gga cat ggt gtt       1613
Leu Trp Asp Ser Gly Leu Asp Tyr Leu His Gly Thr Gly His Gly Val           
                480                 485                 490               

ggg tct ttt ttg aat gtc cat gag ggt cct tgc ggc atc agt tac aaa       1661
Gly Ser Phe Leu Asn Val His Glu Gly Pro Cys Gly Ile Ser Tyr Lys           
            495                 500                 505                   

aca ttc tct gat gag ccc ttg gag gca ggc atg att gtc act gat gag       1709
Thr Phe Ser Asp Glu Pro Leu Glu Ala Gly Met Ile Val Thr Asp Glu           
        510                 515                 520                       

ccc ggg tac tat gaa gat ggg gct ttt gga att cgc att gag aat gtt       1757
Pro Gly Tyr Tyr Glu Asp Gly Ala Phe Gly Ile Arg Ile Glu Asn Val           
    525                 530                 535                           

gtc ctt gtg gtt cct gtg aag acc aag tat aat ttt aat aac cgg gga       1805
Val Leu Val Val Pro Val Lys Thr Lys Tyr Asn Phe Asn Asn Arg Gly           
540                 545                 550                 555           

agc ctg acc ttt gaa cct cta aca ttg gtt cca att cag acc aaa atg       1853
Ser Leu Thr Phe Glu Pro Leu Thr Leu Val Pro Ile Gln Thr Lys Met           
                560                 565                 570               

ata gat gtg gat tct ctt aca gac aaa gag tgc gac tgg ctc aac aat       1901
Ile Asp Val Asp Ser Leu Thr Asp Lys Glu Cys Asp Trp Leu Asn Asn           
            575                 580                 585                   

tac cac ctg acc tgc agg gat gtg att ggg aag gaa ttg cag aaa cag       1949
Tyr His Leu Thr Cys Arg Asp Val Ile Gly Lys Glu Leu Gln Lys Gln           
        590                 595                 600                       

ggc cgc cag gaa gct ctc gag tgg ctc atc aga gag acg caa ccc atc       1997
Gly Arg Gln Glu Ala Leu Glu Trp Leu Ile Arg Glu Thr Gln Pro Ile           
    605                 610                 615                           

tcc aaa cag cat taa taaatacctc cccggttttg tttttgtaaa atgctctgga       2052
Ser Lys Gln His                                                           
620                                                                       

ggaaggaaga aacgtggcag atccctgaca tctttcccct ttcctttcct tcttccctac     2112

ctcccctttt tactttagac tttaagaaga acagaaaatc ttcttatcct ctttgatatt     2172

ttattgcaaa cactcagtct tttatgattt tttaattgtt gagaacaagc caagaataaa     2232

attgctgcac cagaaggagg gtccctccaa agttgaacac ttggtgaaag gaagatgccc     2292

cgacttcttt ggccagtgat ggggaatcag tgagtgctcc atgatggtca tgttccaggt     2352

gctagtacat cattcatgat caccttaatg ctcatgagac tatatttatg atcagtgaat     2412

aaaaatgtca gaactgtgaa aaaaaaaaaa aaaaaa                               2448


<210>  232
<211>  623
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Pro Pro Lys Val Thr Ser Glu Leu Leu Arg Gln Leu Arg Gln Ala 
1               5                   10                  15      


Met Arg Asn Ser Glu Tyr Val Thr Glu Pro Ile Gln Ala Tyr Ile Ile 
            20                  25                  30          


Pro Ser Gly Asp Ala His Gln Ser Glu Tyr Ile Ala Pro Cys Asp Cys 
        35                  40                  45              


Arg Arg Ala Phe Val Ser Gly Phe Asp Gly Ser Ala Gly Thr Ala Ile 
    50                  55                  60                  


Ile Thr Glu Glu His Ala Ala Met Trp Thr Asp Gly Arg Tyr Phe Leu 
65                  70                  75                  80  


Gln Ala Ala Lys Gln Met Asp Ser Asn Trp Thr Leu Met Lys Met Gly 
                85                  90                  95      


Leu Lys Asp Thr Pro Thr Gln Glu Asp Trp Leu Val Ser Val Leu Pro 
            100                 105                 110         


Glu Gly Ser Arg Val Gly Val Asp Pro Leu Ile Ile Pro Thr Asp Tyr 
        115                 120                 125             


Trp Lys Lys Met Ala Lys Val Leu Arg Ser Ala Gly His His Leu Ile 
    130                 135                 140                 


Pro Val Lys Glu Asn Leu Val Asp Lys Ile Trp Thr Asp Arg Pro Glu 
145                 150                 155                 160 


Arg Pro Cys Lys Pro Leu Leu Thr Leu Gly Leu Asp Tyr Thr Gly Ile 
                165                 170                 175     


Ser Trp Lys Asp Lys Val Ala Asp Leu Arg Leu Lys Met Ala Glu Arg 
            180                 185                 190         


Asn Val Met Trp Phe Val Val Thr Ala Leu Asp Glu Ile Ala Trp Leu 
        195                 200                 205             


Phe Asn Leu Arg Gly Ser Asp Val Glu His Asn Pro Val Phe Phe Ser 
    210                 215                 220                 


Tyr Ala Ile Ile Gly Leu Glu Thr Ile Met Leu Phe Ile Asp Gly Asp 
225                 230                 235                 240 


Arg Ile Asp Ala Pro Ser Val Lys Glu His Leu Leu Leu Asp Leu Gly 
                245                 250                 255     


Leu Glu Ala Glu Tyr Arg Ile Gln Val His Pro Tyr Lys Ser Ile Leu 
            260                 265                 270         


Ser Glu Leu Lys Ala Leu Cys Ala Asp Leu Ser Pro Arg Glu Lys Val 
        275                 280                 285             


Trp Val Ser Asp Lys Ala Ser Tyr Ala Val Ser Glu Thr Ile Pro Lys 
    290                 295                 300                 


Asp His Arg Cys Cys Met Pro Tyr Thr Pro Ile Cys Ile Ala Lys Ala 
305                 310                 315                 320 


Val Lys Asn Ser Ala Glu Ser Glu Gly Met Arg Arg Ala His Ile Lys 
                325                 330                 335     


Asp Ala Val Ala Leu Cys Glu Leu Phe Asn Trp Leu Glu Lys Glu Val 
            340                 345                 350         


Pro Lys Gly Gly Val Thr Glu Ile Ser Ala Ala Asp Lys Ala Glu Glu 
        355                 360                 365             


Phe Arg Arg Gln Gln Ala Asp Phe Val Asp Leu Ser Phe Pro Thr Ile 
    370                 375                 380                 


Ser Ser Thr Gly Pro Asn Gly Ala Ile Ile His Tyr Ala Pro Val Pro 
385                 390                 395                 400 


Glu Thr Asn Arg Thr Leu Ser Leu Asp Glu Val Tyr Leu Ile Asp Ser 
                405                 410                 415     


Gly Ala Gln Tyr Lys Asp Gly Thr Thr Asp Val Thr Arg Thr Met His 
            420                 425                 430         


Phe Gly Thr Pro Thr Ala Tyr Glu Lys Glu Cys Phe Thr Tyr Val Leu 
        435                 440                 445             


Lys Gly His Ile Ala Val Ser Ala Ala Val Phe Pro Thr Gly Thr Lys 
    450                 455                 460                 


Gly His Leu Leu Asp Ser Phe Ala Arg Ser Ala Leu Trp Asp Ser Gly 
465                 470                 475                 480 


Leu Asp Tyr Leu His Gly Thr Gly His Gly Val Gly Ser Phe Leu Asn 
                485                 490                 495     


Val His Glu Gly Pro Cys Gly Ile Ser Tyr Lys Thr Phe Ser Asp Glu 
            500                 505                 510         


Pro Leu Glu Ala Gly Met Ile Val Thr Asp Glu Pro Gly Tyr Tyr Glu 
        515                 520                 525             


Asp Gly Ala Phe Gly Ile Arg Ile Glu Asn Val Val Leu Val Val Pro 
    530                 535                 540                 


Val Lys Thr Lys Tyr Asn Phe Asn Asn Arg Gly Ser Leu Thr Phe Glu 
545                 550                 555                 560 


Pro Leu Thr Leu Val Pro Ile Gln Thr Lys Met Ile Asp Val Asp Ser 
                565                 570                 575     


Leu Thr Asp Lys Glu Cys Asp Trp Leu Asn Asn Tyr His Leu Thr Cys 
            580                 585                 590         


Arg Asp Val Ile Gly Lys Glu Leu Gln Lys Gln Gly Arg Gln Glu Ala 
        595                 600                 605             


Leu Glu Trp Leu Ile Arg Glu Thr Gln Pro Ile Ser Lys Gln His 
    610                 615                 620             


<210>  233
<211>  1613
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (324)..(1403)

<400>  233
gccacacagg ctccttggag taagagtgtg agaaactgga tgaagacagc tgtattcttt       60

tggaagcgtt cgagattggt ctgtctctac caactaaaaa cttctagctt aagtgcagag      120

atttaaggag atcaacaaaa actcagtcta gacatattat gaggctggga gggtatcaac      180

agacttgagt tcttgtcagc aagatcacct gcttttaata ttgtcctcag ggtctgagca      240

catctggaag tgaggtcaat caagttagac cccaaaaact tttgtgacaa cagtgaagag      300

gggaaaataa acacaccaca aac atg aac ctc aac ccc ccg aca tct gct ctt      353
                          Met Asn Leu Asn Pro Pro Thr Ser Ala Leu         
                          1               5                   10          

cag atc gag ggc aaa ggc agc cat att atg gct aga aat gta agc tgc        401
Gln Ile Glu Gly Lys Gly Ser His Ile Met Ala Arg Asn Val Ser Cys           
                15                  20                  25                

ttt cta gtc agg cac acc cct cat ccc aga aga gtc tgc cac atc aaa        449
Phe Leu Val Arg His Thr Pro His Pro Arg Arg Val Cys His Ile Lys           
            30                  35                  40                    

ggc ttg aat aac att cca atc tgt act gtg aat gat gat gag aat gca        497
Gly Leu Asn Asn Ile Pro Ile Cys Thr Val Asn Asp Asp Glu Asn Ala           
        45                  50                  55                        

ttt gga aca ttg tgg gaa gtt ggc cag tct aac tac tta gag aag aac        545
Phe Gly Thr Leu Trp Glu Val Gly Gln Ser Asn Tyr Leu Glu Lys Asn           
    60                  65                  70                            

agg ata cca ttt gcc aat tgc agt tac ccc ccg agc act gca gtc cag        593
Arg Ile Pro Phe Ala Asn Cys Ser Tyr Pro Pro Ser Thr Ala Val Gln           
75                  80                  85                  90            

aag agc cct gta aga gga atg tcg cca gcc cca aac ggt gcc aaa gtg        641
Lys Ser Pro Val Arg Gly Met Ser Pro Ala Pro Asn Gly Ala Lys Val           
                95                  100                 105               

cct cca cgg cct cat tct gag ccc agt aga aaa att aaa gag tgc ttc        689
Pro Pro Arg Pro His Ser Glu Pro Ser Arg Lys Ile Lys Glu Cys Phe           
            110                 115                 120                   

aaa act tcc agt gag aat ccc tta gta att aaa aag gaa gaa att aag        737
Lys Thr Ser Ser Glu Asn Pro Leu Val Ile Lys Lys Glu Glu Ile Lys           
        125                 130                 135                       

gcc aaa aga cca cca tca cct cca aag gca tgc tct act cct ggc tcc        785
Ala Lys Arg Pro Pro Ser Pro Pro Lys Ala Cys Ser Thr Pro Gly Ser           
    140                 145                 150                           

tgt tct tca ggg atg aca agt acc aag aat gat gtg aaa gca aac acc        833
Cys Ser Ser Gly Met Thr Ser Thr Lys Asn Asp Val Lys Ala Asn Thr           
155                 160                 165                 170           

att tgc ata cca aac tat ctg gat cag gaa ata aaa atc ctg gca aag        881
Ile Cys Ile Pro Asn Tyr Leu Asp Gln Glu Ile Lys Ile Leu Ala Lys           
                175                 180                 185               

ctc tgt agc att ttg cat act gat tct ctg gca gaa gtt tta cag tgg        929
Leu Cys Ser Ile Leu His Thr Asp Ser Leu Ala Glu Val Leu Gln Trp           
            190                 195                 200                   

ctg ctt cat gca act tca aaa gaa aaa gag tgg gtc tca gct ttg att        977
Leu Leu His Ala Thr Ser Lys Glu Lys Glu Trp Val Ser Ala Leu Ile           
        205                 210                 215                       

cat tct gag ctt gcc gag ata aac ctg tta act cat cac aga aga aac       1025
His Ser Glu Leu Ala Glu Ile Asn Leu Leu Thr His His Arg Arg Asn           
    220                 225                 230                           

acc tca atg gaa cca gca gca gag act ggg aag cca ccc aca gtt aaa       1073
Thr Ser Met Glu Pro Ala Ala Glu Thr Gly Lys Pro Pro Thr Val Lys           
235                 240                 245                 250           

tca cca ccc aca gtt aaa ttg ccc cca aat ttt act gca aaa tca aaa       1121
Ser Pro Pro Thr Val Lys Leu Pro Pro Asn Phe Thr Ala Lys Ser Lys           
                255                 260                 265               

gtg ctg acc aga gat aca gaa ggg gat caa cca acc aga gtg tca agt       1169
Val Leu Thr Arg Asp Thr Glu Gly Asp Gln Pro Thr Arg Val Ser Ser           
            270                 275                 280                   

caa gga tct gaa gaa aac aag gaa gta cca aaa gag gct gag cac aag       1217
Gln Gly Ser Glu Glu Asn Lys Glu Val Pro Lys Glu Ala Glu His Lys           
        285                 290                 295                       

cct cca cta ctt ata aga aga aat aat atg aaa ata cct gtt gca gaa       1265
Pro Pro Leu Leu Ile Arg Arg Asn Asn Met Lys Ile Pro Val Ala Glu           
    300                 305                 310                           

tat ttc agc aaa cca aat tct cct ccc agg cct aac act cag gag agt       1313
Tyr Phe Ser Lys Pro Asn Ser Pro Pro Arg Pro Asn Thr Gln Glu Ser           
315                 320                 325                 330           

gga tca gca aaa cca gtg tca gca agg agt ata caa gaa tac aac ctc       1361
Gly Ser Ala Lys Pro Val Ser Ala Arg Ser Ile Gln Glu Tyr Asn Leu           
                335                 340                 345               

tgt ccc caa aga gca tgt tat cct tca aca cac cgg agg tag               1403
Cys Pro Gln Arg Ala Cys Tyr Pro Ser Thr His Arg Arg                       
            350                 355                                       

aagttctaga ctgggtgaat tctttcatga atatgagctt cacatttaca tcatcaaatt     1463

atttttcaaa tgaatatttt tggtattgag gaatcaagtg gtcctcttta tggtggcaca     1523

tgtaaatcta aaaatacctg tatgtaatgc tacaaataaa tattactgga aatgatattt     1583

ccatttgtag ttaaaaaaaa aaaaaaaaaa                                      1613


<210>  234
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Asn Leu Asn Pro Pro Thr Ser Ala Leu Gln Ile Glu Gly Lys Gly 
1               5                   10                  15      


Ser His Ile Met Ala Arg Asn Val Ser Cys Phe Leu Val Arg His Thr 
            20                  25                  30          


Pro His Pro Arg Arg Val Cys His Ile Lys Gly Leu Asn Asn Ile Pro 
        35                  40                  45              


Ile Cys Thr Val Asn Asp Asp Glu Asn Ala Phe Gly Thr Leu Trp Glu 
    50                  55                  60                  


Val Gly Gln Ser Asn Tyr Leu Glu Lys Asn Arg Ile Pro Phe Ala Asn 
65                  70                  75                  80  


Cys Ser Tyr Pro Pro Ser Thr Ala Val Gln Lys Ser Pro Val Arg Gly 
                85                  90                  95      


Met Ser Pro Ala Pro Asn Gly Ala Lys Val Pro Pro Arg Pro His Ser 
            100                 105                 110         


Glu Pro Ser Arg Lys Ile Lys Glu Cys Phe Lys Thr Ser Ser Glu Asn 
        115                 120                 125             


Pro Leu Val Ile Lys Lys Glu Glu Ile Lys Ala Lys Arg Pro Pro Ser 
    130                 135                 140                 


Pro Pro Lys Ala Cys Ser Thr Pro Gly Ser Cys Ser Ser Gly Met Thr 
145                 150                 155                 160 


Ser Thr Lys Asn Asp Val Lys Ala Asn Thr Ile Cys Ile Pro Asn Tyr 
                165                 170                 175     


Leu Asp Gln Glu Ile Lys Ile Leu Ala Lys Leu Cys Ser Ile Leu His 
            180                 185                 190         


Thr Asp Ser Leu Ala Glu Val Leu Gln Trp Leu Leu His Ala Thr Ser 
        195                 200                 205             


Lys Glu Lys Glu Trp Val Ser Ala Leu Ile His Ser Glu Leu Ala Glu 
    210                 215                 220                 


Ile Asn Leu Leu Thr His His Arg Arg Asn Thr Ser Met Glu Pro Ala 
225                 230                 235                 240 


Ala Glu Thr Gly Lys Pro Pro Thr Val Lys Ser Pro Pro Thr Val Lys 
                245                 250                 255     


Leu Pro Pro Asn Phe Thr Ala Lys Ser Lys Val Leu Thr Arg Asp Thr 
            260                 265                 270         


Glu Gly Asp Gln Pro Thr Arg Val Ser Ser Gln Gly Ser Glu Glu Asn 
        275                 280                 285             


Lys Glu Val Pro Lys Glu Ala Glu His Lys Pro Pro Leu Leu Ile Arg 
    290                 295                 300                 


Arg Asn Asn Met Lys Ile Pro Val Ala Glu Tyr Phe Ser Lys Pro Asn 
305                 310                 315                 320 


Ser Pro Pro Arg Pro Asn Thr Gln Glu Ser Gly Ser Ala Lys Pro Val 
                325                 330                 335     


Ser Ala Arg Ser Ile Gln Glu Tyr Asn Leu Cys Pro Gln Arg Ala Cys 
            340                 345                 350         


Tyr Pro Ser Thr His Arg Arg 
        355                 


<210>  235
<211>  1584
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (160)..(1434)

<400>  235
ggggagagga agagtggtag ggggagggag agagagagga agagtttcca aacttgtctc       60

cagtgacagg agacatttac gttccacaag ataaaactgc cacttagagc ccagggaagc      120

taaaccttcc tggcttggcc taggagctcg agcggagtc atg ggc tct ctg gtc         174
                                           Met Gly Ser Leu Val            
                                           1               5              

ctg aca ctg tgc gct ctt ttc tgc ctg gca gct tac ttg gtt tct ggc        222
Leu Thr Leu Cys Ala Leu Phe Cys Leu Ala Ala Tyr Leu Val Ser Gly           
                10                  15                  20                

agc ccc atc atg aac cta gag cag tct cct ctg gaa gaa gat atg tcc        270
Ser Pro Ile Met Asn Leu Glu Gln Ser Pro Leu Glu Glu Asp Met Ser           
            25                  30                  35                    

ctc ttt ggt gat gtt ttc tca gag caa gac ggt gtc gac ttt aac aca        318
Leu Phe Gly Asp Val Phe Ser Glu Gln Asp Gly Val Asp Phe Asn Thr           
        40                  45                  50                        

ctg ctc cag agc atg aag gat gag ttt ctt aag aca cta aac ctc tct        366
Leu Leu Gln Ser Met Lys Asp Glu Phe Leu Lys Thr Leu Asn Leu Ser           
    55                  60                  65                            

gac atc ccc acg cag gat tca gcc aag gtg gac cca cca gag tac atg        414
Asp Ile Pro Thr Gln Asp Ser Ala Lys Val Asp Pro Pro Glu Tyr Met           
70                  75                  80                  85            

ttg gaa ctc tac aac aaa ttt gca aca gat cgg acc tcc atg ccc tct        462
Leu Glu Leu Tyr Asn Lys Phe Ala Thr Asp Arg Thr Ser Met Pro Ser           
                90                  95                  100               

gcc aac atc att agg agt ttc aag aat gaa gat ctg ttt tcc cag ccg        510
Ala Asn Ile Ile Arg Ser Phe Lys Asn Glu Asp Leu Phe Ser Gln Pro           
            105                 110                 115                   

gtc agt ttt aat ggg ctc cga aaa tac ccc ctc ctc ttc aat gtg tcc        558
Val Ser Phe Asn Gly Leu Arg Lys Tyr Pro Leu Leu Phe Asn Val Ser           
        120                 125                 130                       

att cct cac cat gaa gag gtc atc atg gct gaa ctt agg cta tac aca        606
Ile Pro His His Glu Glu Val Ile Met Ala Glu Leu Arg Leu Tyr Thr           
    135                 140                 145                           

ctg gtg caa agg gat cgt atg ata tac gat gga gta gac cgg aaa att        654
Leu Val Gln Arg Asp Arg Met Ile Tyr Asp Gly Val Asp Arg Lys Ile           
150                 155                 160                 165           

acc att ttt gaa gtg ctg gag agc aaa ggg gat aat gag gga gaa aga        702
Thr Ile Phe Glu Val Leu Glu Ser Lys Gly Asp Asn Glu Gly Glu Arg           
                170                 175                 180               

aac atg ctg gtc ttg gtg tct ggg gag ata tat gga acc aac agt gag        750
Asn Met Leu Val Leu Val Ser Gly Glu Ile Tyr Gly Thr Asn Ser Glu           
            185                 190                 195                   

tgg gag act ttt gat gtc aca gat gcc atc aga cgt tgg caa aag tca        798
Trp Glu Thr Phe Asp Val Thr Asp Ala Ile Arg Arg Trp Gln Lys Ser           
        200                 205                 210                       

ggc tca tcc acc cac cag ctg gag gtc cac att gag agc aaa cac gat        846
Gly Ser Ser Thr His Gln Leu Glu Val His Ile Glu Ser Lys His Asp           
    215                 220                 225                           

gaa gct gag gat gcc agc agt gga cgg cta gaa ata gat acc agt gcc        894
Glu Ala Glu Asp Ala Ser Ser Gly Arg Leu Glu Ile Asp Thr Ser Ala           
230                 235                 240                 245           

cag aat aag cat aac cct ttg ctc atc gtg ttt tct gat gac caa agc        942
Gln Asn Lys His Asn Pro Leu Leu Ile Val Phe Ser Asp Asp Gln Ser           
                250                 255                 260               

agt gac aag gag agg aag gag gaa ctg aat gaa atg att tcc cat gag        990
Ser Asp Lys Glu Arg Lys Glu Glu Leu Asn Glu Met Ile Ser His Glu           
            265                 270                 275                   

caa ctt cca gag ctg gac aac ttg ggc ctg gat agc ttt tcc agt gga       1038
Gln Leu Pro Glu Leu Asp Asn Leu Gly Leu Asp Ser Phe Ser Ser Gly           
        280                 285                 290                       

cct ggg gaa gag gct ttg ttg cag atg aga tca aac atc atc tat gac       1086
Pro Gly Glu Glu Ala Leu Leu Gln Met Arg Ser Asn Ile Ile Tyr Asp           
    295                 300                 305                           

tcc act gcc cga atc aga agg aac gcc aaa gga aac tac tgt aag agg       1134
Ser Thr Ala Arg Ile Arg Arg Asn Ala Lys Gly Asn Tyr Cys Lys Arg           
310                 315                 320                 325           

acc ccg ctc tac atc gac ttc aag gag att ggg tgg gac tcc tgg atc       1182
Thr Pro Leu Tyr Ile Asp Phe Lys Glu Ile Gly Trp Asp Ser Trp Ile           
                330                 335                 340               

atc gct ccg cct gga tac gaa gcc tat gaa tgc cgt ggt gtt tgt aac       1230
Ile Ala Pro Pro Gly Tyr Glu Ala Tyr Glu Cys Arg Gly Val Cys Asn           
            345                 350                 355                   

tac ccc ctg gca gag cat ctc aca ccc aca aag cat gca att atc cag       1278
Tyr Pro Leu Ala Glu His Leu Thr Pro Thr Lys His Ala Ile Ile Gln           
        360                 365                 370                       

gcc ttg gtc cac ctc aag aat tcc cag aaa gct tcc aaa gcc tgc tgt       1326
Ala Leu Val His Leu Lys Asn Ser Gln Lys Ala Ser Lys Ala Cys Cys           
    375                 380                 385                           

gtg ccc aca aag cta gag ccc atc tcc atc ctc tat tta gac aaa ggc       1374
Val Pro Thr Lys Leu Glu Pro Ile Ser Ile Leu Tyr Leu Asp Lys Gly           
390                 395                 400                 405           

gtc gtc acc tac aag ttt aaa tac gaa ggc atg gcc gtc tcc gaa tgt       1422
Val Val Thr Tyr Lys Phe Lys Tyr Glu Gly Met Ala Val Ser Glu Cys           
                410                 415                 420               

ggc tgt aga tag aagaagagtc ctatggctta tttaataact gtaaatgtgt           1474
Gly Cys Arg                                                               
                                                                          

atatttggtg ttcctattta atgagattat ttaataaggg tgtacagtaa tagaggcttg     1534

ctgccttcag gaaatggaca ggtcagtttg ttgtaggaaa tgcatatttt                1584


<210>  236
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Gly Ser Leu Val Leu Thr Leu Cys Ala Leu Phe Cys Leu Ala Ala 
1               5                   10                  15      


Tyr Leu Val Ser Gly Ser Pro Ile Met Asn Leu Glu Gln Ser Pro Leu 
            20                  25                  30          


Glu Glu Asp Met Ser Leu Phe Gly Asp Val Phe Ser Glu Gln Asp Gly 
        35                  40                  45              


Val Asp Phe Asn Thr Leu Leu Gln Ser Met Lys Asp Glu Phe Leu Lys 
    50                  55                  60                  


Thr Leu Asn Leu Ser Asp Ile Pro Thr Gln Asp Ser Ala Lys Val Asp 
65                  70                  75                  80  


Pro Pro Glu Tyr Met Leu Glu Leu Tyr Asn Lys Phe Ala Thr Asp Arg 
                85                  90                  95      


Thr Ser Met Pro Ser Ala Asn Ile Ile Arg Ser Phe Lys Asn Glu Asp 
            100                 105                 110         


Leu Phe Ser Gln Pro Val Ser Phe Asn Gly Leu Arg Lys Tyr Pro Leu 
        115                 120                 125             


Leu Phe Asn Val Ser Ile Pro His His Glu Glu Val Ile Met Ala Glu 
    130                 135                 140                 


Leu Arg Leu Tyr Thr Leu Val Gln Arg Asp Arg Met Ile Tyr Asp Gly 
145                 150                 155                 160 


Val Asp Arg Lys Ile Thr Ile Phe Glu Val Leu Glu Ser Lys Gly Asp 
                165                 170                 175     


Asn Glu Gly Glu Arg Asn Met Leu Val Leu Val Ser Gly Glu Ile Tyr 
            180                 185                 190         


Gly Thr Asn Ser Glu Trp Glu Thr Phe Asp Val Thr Asp Ala Ile Arg 
        195                 200                 205             


Arg Trp Gln Lys Ser Gly Ser Ser Thr His Gln Leu Glu Val His Ile 
    210                 215                 220                 


Glu Ser Lys His Asp Glu Ala Glu Asp Ala Ser Ser Gly Arg Leu Glu 
225                 230                 235                 240 


Ile Asp Thr Ser Ala Gln Asn Lys His Asn Pro Leu Leu Ile Val Phe 
                245                 250                 255     


Ser Asp Asp Gln Ser Ser Asp Lys Glu Arg Lys Glu Glu Leu Asn Glu 
            260                 265                 270         


Met Ile Ser His Glu Gln Leu Pro Glu Leu Asp Asn Leu Gly Leu Asp 
        275                 280                 285             


Ser Phe Ser Ser Gly Pro Gly Glu Glu Ala Leu Leu Gln Met Arg Ser 
    290                 295                 300                 


Asn Ile Ile Tyr Asp Ser Thr Ala Arg Ile Arg Arg Asn Ala Lys Gly 
305                 310                 315                 320 


Asn Tyr Cys Lys Arg Thr Pro Leu Tyr Ile Asp Phe Lys Glu Ile Gly 
                325                 330                 335     


Trp Asp Ser Trp Ile Ile Ala Pro Pro Gly Tyr Glu Ala Tyr Glu Cys 
            340                 345                 350         


Arg Gly Val Cys Asn Tyr Pro Leu Ala Glu His Leu Thr Pro Thr Lys 
        355                 360                 365             


His Ala Ile Ile Gln Ala Leu Val His Leu Lys Asn Ser Gln Lys Ala 
    370                 375                 380                 


Ser Lys Ala Cys Cys Val Pro Thr Lys Leu Glu Pro Ile Ser Ile Leu 
385                 390                 395                 400 


Tyr Leu Asp Lys Gly Val Val Thr Tyr Lys Phe Lys Tyr Glu Gly Met 
                405                 410                 415     


Ala Val Ser Glu Cys Gly Cys Arg 
            420                 


<210>  237
<211>  7706
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (872)..(6445)

<400>  237
ctgaggctca gccctcctcg gagcccacca tctcgaggct cctggactgt aagggacccc       60

tgcagtcccc agagcagagg ccagcagggg ctgagactat gaggcaagca gcccatcgac      120

ccaggcctcc ttaggaccag cccagccacc cagcaagcga aagagcagca gcagagagca      180

gagccggaga taaaggacca cagcggacca ctggggatca cccccagcag ctcctgaagc      240

ctctggccgg gctgaggggt tgcgacagac ggccagaccc acagacactg acagacacac      300

aacgacaccg atgcacacag ctgcacgaca ctgacacact cagatacaac cagggacagc      360

atcacatact gccacagccc tgcaatacag acacccacac acacacacac aaacaactgg      420

caactctgaa atgggcagac agtgacacac agcaccaccc ccctcaacac acagaagtgg      480

gggcacccat cttcccaaca catgagacag cattgacctg cacggacaga cctggagaca      540

cacacacgca ccctcaccca ggcgcagctg tcggtggcct ctgcacatcc tccctacccc      600

cacagggaca ccctcgctcc tccacatact cgcgcacaca cacagctacc agcaaacata      660

gctcacatac ccctggctcc agctccagca gccctggcgc cttctgcagc ctcctttgtg      720

ggtggggaag agctcagcca accttggatg gagcgtcggt gaagcaagag ctcagagggg      780

agaggggctg gcctggcatg accctcgcca gtccccccac ctggctgggt gatgtccccc      840

ggcccgggtt ctggggcccc ttggcagtac c atg gag caa ctg aca acc ctc         892
                                   Met Glu Gln Leu Thr Thr Leu            
                                   1               5                      

cca cgg cct ggg gac cct gga gcc atg gag cca tgg gca ctg ccc acc        940
Pro Arg Pro Gly Asp Pro Gly Ala Met Glu Pro Trp Ala Leu Pro Thr           
        10                  15                  20                        

tgg cat agc tgg act cca ggt cga ggg ggt gaa cct agc agt gca gcc        988
Trp His Ser Trp Thr Pro Gly Arg Gly Gly Glu Pro Ser Ser Ala Ala           
    25                  30                  35                            

cca agc atc gct gat act cct ccg gca gct ctg cag ctt caa gaa ctg       1036
Pro Ser Ile Ala Asp Thr Pro Pro Ala Ala Leu Gln Leu Gln Glu Leu           
40                  45                  50                  55            

agg tct gag gag agt tcc aag ccc aaa gga gac ggg agc tcc agg ccc       1084
Arg Ser Glu Glu Ser Ser Lys Pro Lys Gly Asp Gly Ser Ser Arg Pro           
                60                  65                  70                

gtg ggg gga act gac cct gaa gga gca gag gct tgt ctg ccc agc ctg       1132
Val Gly Gly Thr Asp Pro Glu Gly Ala Glu Ala Cys Leu Pro Ser Leu           
            75                  80                  85                    

ggc cag caa gca tcc agc tct gga ccc gcc tgc cag agg cca gag gat       1180
Gly Gln Gln Ala Ser Ser Ser Gly Pro Ala Cys Gln Arg Pro Glu Asp           
        90                  95                  100                       

gag gaa gtg gag gct ttc ctg aag gcc aag ctg aat atg agc ttt ggg       1228
Glu Glu Val Glu Ala Phe Leu Lys Ala Lys Leu Asn Met Ser Phe Gly           
    105                 110                 115                           

gac agg ccc aat ctg gag ctg ctg agg gcc ctg ggg gag ctg cgg cag       1276
Asp Arg Pro Asn Leu Glu Leu Leu Arg Ala Leu Gly Glu Leu Arg Gln           
120                 125                 130                 135           

cgc tgt gcc atc ctt aag gag gaa aac cag atg ctg agg aag agc agc       1324
Arg Cys Ala Ile Leu Lys Glu Glu Asn Gln Met Leu Arg Lys Ser Ser           
                140                 145                 150               

ttc cct gag aca gaa gag aag gtg cgg agg ctg aag agg aag aac gcc       1372
Phe Pro Glu Thr Glu Glu Lys Val Arg Arg Leu Lys Arg Lys Asn Ala           
            155                 160                 165                   

gag ctg gcg gtc att gcc aag cgc ctg gag gag agg gcc cga aag ctg       1420
Glu Leu Ala Val Ile Ala Lys Arg Leu Glu Glu Arg Ala Arg Lys Leu           
        170                 175                 180                       

cag gaa acg aac ctg agg gtg gtg agt gcc ccc ttg ccc cgg ccg ggg       1468
Gln Glu Thr Asn Leu Arg Val Val Ser Ala Pro Leu Pro Arg Pro Gly           
    185                 190                 195                           

acc agc ttg gag ttg tgt cgg aag gcc cta gcc cgc cag cga gcc cgg       1516
Thr Ser Leu Glu Leu Cys Arg Lys Ala Leu Ala Arg Gln Arg Ala Arg           
200                 205                 210                 215           

gac ctc agt gag aca gcc agt gca ctg ctg gcc aag gac aag cag att       1564
Asp Leu Ser Glu Thr Ala Ser Ala Leu Leu Ala Lys Asp Lys Gln Ile           
                220                 225                 230               

gct gcc ttg cag cgg gag tgc agg gag ctg cag gcc agg ctc act ctg       1612
Ala Ala Leu Gln Arg Glu Cys Arg Glu Leu Gln Ala Arg Leu Thr Leu           
            235                 240                 245                   

gtg ggc aag gag ggt ccc cag tgg ctc cac gtg cgg gac ttc gat cgg       1660
Val Gly Lys Glu Gly Pro Gln Trp Leu His Val Arg Asp Phe Asp Arg           
        250                 255                 260                       

ctg ctg cgc gag tcc cag cgg gag gtg ctg cgg ctg cag agg cag atc       1708
Leu Leu Arg Glu Ser Gln Arg Glu Val Leu Arg Leu Gln Arg Gln Ile           
    265                 270                 275                           

gcg ctg cgc aac cag cgg gag acg ctc ccg ctc ccg ccg tcc tgg ccc       1756
Ala Leu Arg Asn Gln Arg Glu Thr Leu Pro Leu Pro Pro Ser Trp Pro           
280                 285                 290                 295           

ccg ggc cct gct ctc cag gcc aga gca ggg gcg cct gct ccc ggg gcc       1804
Pro Gly Pro Ala Leu Gln Ala Arg Ala Gly Ala Pro Ala Pro Gly Ala           
                300                 305                 310               

ccg gga gag gcc acg ccc cag gag gat gcg gac aac cta ccc gtg att       1852
Pro Gly Glu Ala Thr Pro Gln Glu Asp Ala Asp Asn Leu Pro Val Ile           
            315                 320                 325                   

cta ggg gag cca gag aaa gag cag agg gtg cag cag ctg gaa tcg gag       1900
Leu Gly Glu Pro Glu Lys Glu Gln Arg Val Gln Gln Leu Glu Ser Glu           
        330                 335                 340                       

ctc agc aag aag cgg aag aaa tgc gag agc ctg gag cag gaa gcc cgg       1948
Leu Ser Lys Lys Arg Lys Lys Cys Glu Ser Leu Glu Gln Glu Ala Arg           
    345                 350                 355                           

aaa aag cag agg cga tgt gag gag ctg gaa ctg cag ctg aga caa gcg       1996
Lys Lys Gln Arg Arg Cys Glu Glu Leu Glu Leu Gln Leu Arg Gln Ala           
360                 365                 370                 375           

cag aat gag aat gcc cgc ctg gtg gag gag aac tcc cgg ctc agt ggg       2044
Gln Asn Glu Asn Ala Arg Leu Val Glu Glu Asn Ser Arg Leu Ser Gly           
                380                 385                 390               

aga gcc aca gag aag gag cag gtg gag tgg gag aat gcg gag ctg agg       2092
Arg Ala Thr Glu Lys Glu Gln Val Glu Trp Glu Asn Ala Glu Leu Arg           
            395                 400                 405                   

ggc cag ctc ctg ggg gtg aca cag gag agg gac tca gcc ctt cgc aag       2140
Gly Gln Leu Leu Gly Val Thr Gln Glu Arg Asp Ser Ala Leu Arg Lys           
        410                 415                 420                       

agc cag ggc ctg cag agc aag ctg gag agc ctg gag caa gtg ctg aag       2188
Ser Gln Gly Leu Gln Ser Lys Leu Glu Ser Leu Glu Gln Val Leu Lys           
    425                 430                 435                           

cac atg cgg gag gtg gcc cag cgg cgg cag cag ctg gag gtg gag cat       2236
His Met Arg Glu Val Ala Gln Arg Arg Gln Gln Leu Glu Val Glu His           
440                 445                 450                 455           

gaa cag gct cgg ctc agc cta cgg gag aag cag gag gag gtc cgg aga       2284
Glu Gln Ala Arg Leu Ser Leu Arg Glu Lys Gln Glu Glu Val Arg Arg           
                460                 465                 470               

ctg cag cag gcc cag gct gaa gcc cag agg gaa cat gaa gga gcc gtg       2332
Leu Gln Gln Ala Gln Ala Glu Ala Gln Arg Glu His Glu Gly Ala Val           
            475                 480                 485                   

cag ctg ctg gag tct acc ttg gat tcc atg cag gcc cgg gtt cga gag       2380
Gln Leu Leu Glu Ser Thr Leu Asp Ser Met Gln Ala Arg Val Arg Glu           
        490                 495                 500                       

ctc gaa gaa cag tgc cgc agc caa acc gag cag ttc agc ctc ctg gca       2428
Leu Glu Glu Gln Cys Arg Ser Gln Thr Glu Gln Phe Ser Leu Leu Ala           
    505                 510                 515                           

cag gaa ctc cag gct ttc cgc ctg cac ccg ggc ccc ttg gat ctg ctc       2476
Gln Glu Leu Gln Ala Phe Arg Leu His Pro Gly Pro Leu Asp Leu Leu           
520                 525                 530                 535           

aca tct gcc ctg gac tgt ggg agc ctt gga gac tgc cca cca ccc ccc       2524
Thr Ser Ala Leu Asp Cys Gly Ser Leu Gly Asp Cys Pro Pro Pro Pro           
                540                 545                 550               

tgc tgc tgc tcc att ccc cag cct tgc cgg ggg tct ggc ccc aaa gac       2572
Cys Cys Cys Ser Ile Pro Gln Pro Cys Arg Gly Ser Gly Pro Lys Asp           
            555                 560                 565                   

ctt gac ctc ccg ccg ggc tcc cct ggg cgc tgc acc cca aag tct tcc       2620
Leu Asp Leu Pro Pro Gly Ser Pro Gly Arg Cys Thr Pro Lys Ser Ser           
        570                 575                 580                       

gag cct gcc cct gcc act ctc act ggg gtc cct cga agg aca gcc aag       2668
Glu Pro Ala Pro Ala Thr Leu Thr Gly Val Pro Arg Arg Thr Ala Lys           
    585                 590                 595                           

aag gca gag tct ctc tcc aac tcc tcc cac tcc gag tcc atc cac aac       2716
Lys Ala Glu Ser Leu Ser Asn Ser Ser His Ser Glu Ser Ile His Asn           
600                 605                 610                 615           

agc ccc aag tca tgc cct aca cct gag gtg gac aca gcc agt gag gta       2764
Ser Pro Lys Ser Cys Pro Thr Pro Glu Val Asp Thr Ala Ser Glu Val           
                620                 625                 630               

gag gag ctg gag gca gac agt gtc tcc ctg ctc cca gct gcg cca gag       2812
Glu Glu Leu Glu Ala Asp Ser Val Ser Leu Leu Pro Ala Ala Pro Glu           
            635                 640                 645                   

ggc agc cgg gga gga gcc agg atc cag gtc ttc cta gca cgt tat agc       2860
Gly Ser Arg Gly Gly Ala Arg Ile Gln Val Phe Leu Ala Arg Tyr Ser           
        650                 655                 660                       

tac aac ccc ttt gag ggt ccc aat gag aat cca gaa gca gag ctt ccg       2908
Tyr Asn Pro Phe Glu Gly Pro Asn Glu Asn Pro Glu Ala Glu Leu Pro           
    665                 670                 675                           

ctg aca gct ggc gag tac atc tac atc tat ggc aac atg gat gag gat       2956
Leu Thr Ala Gly Glu Tyr Ile Tyr Ile Tyr Gly Asn Met Asp Glu Asp           
680                 685                 690                 695           

ggc ttt ttt gaa gga gag ctc atg gat ggc cga agg ggc ctg gtc cct       3004
Gly Phe Phe Glu Gly Glu Leu Met Asp Gly Arg Arg Gly Leu Val Pro           
                700                 705                 710               

tcc aat ttt gta gag cgt gtg tcg gat gat gac ctc ctg acc tcc ctc       3052
Ser Asn Phe Val Glu Arg Val Ser Asp Asp Asp Leu Leu Thr Ser Leu           
            715                 720                 725                   

cct cca gag ctg gcc gat ttg tcc cac agc tca ggc cct gaa ctc agt       3100
Pro Pro Glu Leu Ala Asp Leu Ser His Ser Ser Gly Pro Glu Leu Ser           
        730                 735                 740                       

ttc ctg agt gta ggt ggg ggt ggc agc agt agc ggg ggc caa agc agt       3148
Phe Leu Ser Val Gly Gly Gly Gly Ser Ser Ser Gly Gly Gln Ser Ser           
    745                 750                 755                           

gtg gga agg agc cag ccc aga cct gag gag gag gat gca ggg gac gag       3196
Val Gly Arg Ser Gln Pro Arg Pro Glu Glu Glu Asp Ala Gly Asp Glu           
760                 765                 770                 775           

ctc agt ctg agc cca tca ccg gag ggc ctg ggc gag cct cct gcc gtg       3244
Leu Ser Leu Ser Pro Ser Pro Glu Gly Leu Gly Glu Pro Pro Ala Val           
                780                 785                 790               

cct tac ccc cgc cgt ctg gtg gtc ctc aag cag ctg gcc cac agc gtg       3292
Pro Tyr Pro Arg Arg Leu Val Val Leu Lys Gln Leu Ala His Ser Val           
            795                 800                 805                   

gtg ctg gcc tgg gag ccg cct cct gag caa gtg gag cta cac ggc ttc       3340
Val Leu Ala Trp Glu Pro Pro Pro Glu Gln Val Glu Leu His Gly Phe           
        810                 815                 820                       

cat atc tgt gtg aat ggg gag ctg cga cag gcc ctg ggg cct ggg gcg       3388
His Ile Cys Val Asn Gly Glu Leu Arg Gln Ala Leu Gly Pro Gly Ala           
    825                 830                 835                           

cca ccc aag gcc gtg ctg gag aac ctg gac ctg tgg gcc ggg ccc ctt       3436
Pro Pro Lys Ala Val Leu Glu Asn Leu Asp Leu Trp Ala Gly Pro Leu           
840                 845                 850                 855           

cac att tct gtc cag gcc ctg act agc cgg ggc agc tct gac cca ctg       3484
His Ile Ser Val Gln Ala Leu Thr Ser Arg Gly Ser Ser Asp Pro Leu           
                860                 865                 870               

cgc tgt tgc ttg gcg gtg ggt gcc cgg gcc gga gtg gtg ccc agc cag       3532
Arg Cys Cys Leu Ala Val Gly Ala Arg Ala Gly Val Val Pro Ser Gln           
            875                 880                 885                   

ctg cgg gtc cat cgg ttg aca gcc aca tct gct gag atc acc tgg gtg       3580
Leu Arg Val His Arg Leu Thr Ala Thr Ser Ala Glu Ile Thr Trp Val           
        890                 895                 900                       

ccc ggc aat agc aac ttg gcc cat gcc atc tac ctc aat ggg gaa gag       3628
Pro Gly Asn Ser Asn Leu Ala His Ala Ile Tyr Leu Asn Gly Glu Glu           
    905                 910                 915                           

tgc cca cct gcc agc ccc agt acc tac tgg gcc acc ttc tgc cac tta       3676
Cys Pro Pro Ala Ser Pro Ser Thr Tyr Trp Ala Thr Phe Cys His Leu           
920                 925                 930                 935           

cgg cct ggc aca ccc tat cag gcc caa gtg gag gct cag ctc cca ccc       3724
Arg Pro Gly Thr Pro Tyr Gln Ala Gln Val Glu Ala Gln Leu Pro Pro           
                940                 945                 950               

caa ggg ccc tgg gaa cca ggc tgg gag agg ctg gag cag cgg gct gcc       3772
Gln Gly Pro Trp Glu Pro Gly Trp Glu Arg Leu Glu Gln Arg Ala Ala           
            955                 960                 965                   

acc ctg cag ttc acc aca ctc cca gca ggc cca cct gat gcc cct ctg       3820
Thr Leu Gln Phe Thr Thr Leu Pro Ala Gly Pro Pro Asp Ala Pro Leu           
        970                 975                 980                       

gat gtg cag atc gag cct ggg ccc tcc cct ggg atc ttg atc atc agt       3868
Asp Val Gln Ile Glu Pro Gly Pro Ser Pro Gly Ile Leu Ile Ile Ser           
    985                 990                 995                           

tgg  ctc cca gtc acc atc  gat gct gct ggc aca  tcc aac ggt gtc        3913
Trp  Leu Pro Val Thr Ile  Asp Ala Ala Gly Thr  Ser Asn Gly Val            
1000                 1005                 1010                            

cgg  gtc aca ggc tat gcc  atc tac gct gat ggg  cag aag atc atg        3958
Arg  Val Thr Gly Tyr Ala  Ile Tyr Ala Asp Gly  Gln Lys Ile Met            
1015                 1020                 1025                            

gag  gtg gcc tca ccc acg  gca ggc agt gta ctg  gtg gag ttg tcc        4003
Glu  Val Ala Ser Pro Thr  Ala Gly Ser Val Leu  Val Glu Leu Ser            
1030                 1035                 1040                            

cag  ctg cag ctg ctg cag  gtg tgt cgt gag gtg  gtc gtg cgc acc        4048
Gln  Leu Gln Leu Leu Gln  Val Cys Arg Glu Val  Val Val Arg Thr            
1045                 1050                 1055                            

atg  tcg ccc cac ggg gag  tcg gcg gac tcc atc  ccg gct cct atc        4093
Met  Ser Pro His Gly Glu  Ser Ala Asp Ser Ile  Pro Ala Pro Ile            
1060                 1065                 1070                            

act  ccc gcc ctg gct ccg  gcc agc ctg cca gcc  cga gtc tcc tgc        4138
Thr  Pro Ala Leu Ala Pro  Ala Ser Leu Pro Ala  Arg Val Ser Cys            
1075                 1080                 1085                            

ccc  tca ccg cac cca agc  cca gag gcc aga gcg  ccc ctt gct tca        4183
Pro  Ser Pro His Pro Ser  Pro Glu Ala Arg Ala  Pro Leu Ala Ser            
1090                 1095                 1100                            

gcc  tcc cca ggg cct gga  gac ccc agc tct cct  ctc cag cac cct        4228
Ala  Ser Pro Gly Pro Gly  Asp Pro Ser Ser Pro  Leu Gln His Pro            
1105                 1110                 1115                            

gct  ccc ctt gga act caa  gag cct cca gga gca  ccc cct gca agc        4273
Ala  Pro Leu Gly Thr Gln  Glu Pro Pro Gly Ala  Pro Pro Ala Ser            
1120                 1125                 1130                            

cct  tcc aga gag atg gca  aaa ggg tcc cac gag  gac cct cca gca        4318
Pro  Ser Arg Glu Met Ala  Lys Gly Ser His Glu  Asp Pro Pro Ala            
1135                 1140                 1145                            

cct  tgc tcc cag gag gag  gct ggg gca gca gtg  ctg ggc acc tca        4363
Pro  Cys Ser Gln Glu Glu  Ala Gly Ala Ala Val  Leu Gly Thr Ser            
1150                 1155                 1160                            

gag  gag agg aca gcc agc  aca tct acc ctg ggt  gag aag gac cct        4408
Glu  Glu Arg Thr Ala Ser  Thr Ser Thr Leu Gly  Glu Lys Asp Pro            
1165                 1170                 1175                            

ggc  ccc gca gct ccc tca  ctg gcc aag cag gag  gcc gag tgg act        4453
Gly  Pro Ala Ala Pro Ser  Leu Ala Lys Gln Glu  Ala Glu Trp Thr            
1180                 1185                 1190                            

gca  gga gag gcc tgt ccg  gcc tcc agc tcc acc  cag gga gca cgg        4498
Ala  Gly Glu Ala Cys Pro  Ala Ser Ser Ser Thr  Gln Gly Ala Arg            
1195                 1200                 1205                            

gcc  cag cag gcg cca aat  acc gag atg tgc caa  gga gga gac cca        4543
Ala  Gln Gln Ala Pro Asn  Thr Glu Met Cys Gln  Gly Gly Asp Pro            
1210                 1215                 1220                            

ggg  tct ggg ctg agg ccc  agg gct gag aag gag  gac aca gca gag        4588
Gly  Ser Gly Leu Arg Pro  Arg Ala Glu Lys Glu  Asp Thr Ala Glu            
1225                 1230                 1235                            

ctt  ggg gtt cat ctg gtg  aac tcc ctc gtg gac  cac ggc cgc aac        4633
Leu  Gly Val His Leu Val  Asn Ser Leu Val Asp  His Gly Arg Asn            
1240                 1245                 1250                            

tca  gac ctg tca gac atc  cag gag gaa gag gaa  gag gag gag gag        4678
Ser  Asp Leu Ser Asp Ile  Gln Glu Glu Glu Glu  Glu Glu Glu Glu            
1255                 1260                 1265                            

gag  gag gaa gag gag ctg  ggt tcc agg act tgc  tcc ttc cag aag        4723
Glu  Glu Glu Glu Glu Leu  Gly Ser Arg Thr Cys  Ser Phe Gln Lys            
1270                 1275                 1280                            

cag  gtt gct ggc aac agc  atc agg gag aat ggg  gcc aag tcc cag        4768
Gln  Val Ala Gly Asn Ser  Ile Arg Glu Asn Gly  Ala Lys Ser Gln            
1285                 1290                 1295                            

ccc  gac ccc ttt tgt gag  act gac agc gat gag  gag atc ttg gag        4813
Pro  Asp Pro Phe Cys Glu  Thr Asp Ser Asp Glu  Glu Ile Leu Glu            
1300                 1305                 1310                            

cag  atc ctg gag ctg ccc  ctc cag cag ttc tgt  agc aag aag ctc        4858
Gln  Ile Leu Glu Leu Pro  Leu Gln Gln Phe Cys  Ser Lys Lys Leu            
1315                 1320                 1325                            

ttt  agc atc ccg gag gag  gag gaa gag gaa gag  gag gac gag gag        4903
Phe  Ser Ile Pro Glu Glu  Glu Glu Glu Glu Glu  Glu Asp Glu Glu            
1330                 1335                 1340                            

gag  gag aag tca ggg gca  ggc tgt tct tcc cga  gac cct ggc ccg        4948
Glu  Glu Lys Ser Gly Ala  Gly Cys Ser Ser Arg  Asp Pro Gly Pro            
1345                 1350                 1355                            

cct  gaa cct gca ttg ctg  ggg ctg ggc tgt gac  agt ggt cag ccc        4993
Pro  Glu Pro Ala Leu Leu  Gly Leu Gly Cys Asp  Ser Gly Gln Pro            
1360                 1365                 1370                            

cga  aga cct ggc cag tgt  ccc ttg tct cct gag  tcc tcc agg gct        5038
Arg  Arg Pro Gly Gln Cys  Pro Leu Ser Pro Glu  Ser Ser Arg Ala            
1375                 1380                 1385                            

gga  gac tgc ctg gaa gac  atg cct gga tta gtt  ggt gga agc agc        5083
Gly  Asp Cys Leu Glu Asp  Met Pro Gly Leu Val  Gly Gly Ser Ser            
1390                 1395                 1400                            

cgg  agg aga gga ggg ggc  tcc cct gag aag ccc  cca agc cgc agg        5128
Arg  Arg Arg Gly Gly Gly  Ser Pro Glu Lys Pro  Pro Ser Arg Arg            
1405                 1410                 1415                            

cgg  cct cca gat ccc cga  gaa cac tgc agc cga  ctt ctc agc aac        5173
Arg  Pro Pro Asp Pro Arg  Glu His Cys Ser Arg  Leu Leu Ser Asn            
1420                 1425                 1430                            

aat  ggg ccc cag gcc tct  gga cga ctg ggc ccc  aca cgg gag agg        5218
Asn  Gly Pro Gln Ala Ser  Gly Arg Leu Gly Pro  Thr Arg Glu Arg            
1435                 1440                 1445                            

ggt  ggc ctc ccc gta att  gag ggc ccc agg act  gga cta gag gct        5263
Gly  Gly Leu Pro Val Ile  Glu Gly Pro Arg Thr  Gly Leu Glu Ala            
1450                 1455                 1460                            

agc  ggg aga ggc cgg ctg  ggc cct tcc cgg agg  tgc tcc cgt ggc        5308
Ser  Gly Arg Gly Arg Leu  Gly Pro Ser Arg Arg  Cys Ser Arg Gly            
1465                 1470                 1475                            

cgg  gcg ctg gag cct ggc  ctg gcc agc tgc ctt  tcc ccc aag tgc        5353
Arg  Ala Leu Glu Pro Gly  Leu Ala Ser Cys Leu  Ser Pro Lys Cys            
1480                 1485                 1490                            

ttg  gaa atc agc att gaa  tat gat tcg gag gat  gag cag gag gcg        5398
Leu  Glu Ile Ser Ile Glu  Tyr Asp Ser Glu Asp  Glu Gln Glu Ala            
1495                 1500                 1505                            

ggc  agc ggg ggc atc agc  atc acc agc tcc tgc  tac cct gga gat        5443
Gly  Ser Gly Gly Ile Ser  Ile Thr Ser Ser Cys  Tyr Pro Gly Asp            
1510                 1515                 1520                            

ggg  gag gcc tgg ggc aca  gca act gta gga agg  ccc agg ggg cct        5488
Gly  Glu Ala Trp Gly Thr  Ala Thr Val Gly Arg  Pro Arg Gly Pro            
1525                 1530                 1535                            

ccg  aag gcc aat tca ggc  ccc aag ccc tac cca  cgc ctc cca gcc        5533
Pro  Lys Ala Asn Ser Gly  Pro Lys Pro Tyr Pro  Arg Leu Pro Ala            
1540                 1545                 1550                            

tgg  gag aaa ggg gaa cca  gag cgg aga ggc cgc  agt gcg acg ggc        5578
Trp  Glu Lys Gly Glu Pro  Glu Arg Arg Gly Arg  Ser Ala Thr Gly            
1555                 1560                 1565                            

aga  gcc aag gag cca ctc  tcc cgg gca aca gag  acc gga gag gcc        5623
Arg  Ala Lys Glu Pro Leu  Ser Arg Ala Thr Glu  Thr Gly Glu Ala            
1570                 1575                 1580                            

aga  ggg cag gac ggc tct  ggg cgg agg ggc ccc  cag aag aga ggt        5668
Arg  Gly Gln Asp Gly Ser  Gly Arg Arg Gly Pro  Gln Lys Arg Gly            
1585                 1590                 1595                            

gtc  cga gtc ctc agg cca  agc act gca gag cta  gtc cct gcg agg        5713
Val  Arg Val Leu Arg Pro  Ser Thr Ala Glu Leu  Val Pro Ala Arg            
1600                 1605                 1610                            

agc  ccc tca gaa aca ctg  gct tac cag cac cta  ccc gtc agg atc        5758
Ser  Pro Ser Glu Thr Leu  Ala Tyr Gln His Leu  Pro Val Arg Ile            
1615                 1620                 1625                            

ttt  gtg gct ctg ttt gac  tat gac ccc gtg tca  atg tcg ccc aat        5803
Phe  Val Ala Leu Phe Asp  Tyr Asp Pro Val Ser  Met Ser Pro Asn            
1630                 1635                 1640                            

cct  gat gct gga gaa gaa  gag ctt ccc ttc cga  gag ggt cag atc        5848
Pro  Asp Ala Gly Glu Glu  Glu Leu Pro Phe Arg  Glu Gly Gln Ile            
1645                 1650                 1655                            

ctg  aag gtg ttt ggg gac  aag gat gcc gat ggc  ttc tac cag ggc        5893
Leu  Lys Val Phe Gly Asp  Lys Asp Ala Asp Gly  Phe Tyr Gln Gly            
1660                 1665                 1670                            

gaa  ggt ggg ggc cgg aca  ggc tac att ccc tgc  aac atg gtg gct        5938
Glu  Gly Gly Gly Arg Thr  Gly Tyr Ile Pro Cys  Asn Met Val Ala            
1675                 1680                 1685                            

gag  gtg gct gtg gac agc  cct gct ggg aga cag  caa ctg ctc cag        5983
Glu  Val Ala Val Asp Ser  Pro Ala Gly Arg Gln  Gln Leu Leu Gln            
1690                 1695                 1700                            

cgg  ggt tat ttg tcc cca  gat att ctc ctt gag  ggc tca ggg aat        6028
Arg  Gly Tyr Leu Ser Pro  Asp Ile Leu Leu Glu  Gly Ser Gly Asn            
1705                 1710                 1715                            

ggt  ccg ttt gtg tac tcc  aca gcc cac aca act  ggg cct cct ccc        6073
Gly  Pro Phe Val Tyr Ser  Thr Ala His Thr Thr  Gly Pro Pro Pro            
1720                 1725                 1730                            

aag  ccc cgc cgc tcc aag  aaa gct gag tcg gaa  ggc cct gcc cag        6118
Lys  Pro Arg Arg Ser Lys  Lys Ala Glu Ser Glu  Gly Pro Ala Gln            
1735                 1740                 1745                            

ccc  tgt cca ggc ccc cct  aag ctg gtc ccc tct  gct gac ctg aaa        6163
Pro  Cys Pro Gly Pro Pro  Lys Leu Val Pro Ser  Ala Asp Leu Lys            
1750                 1755                 1760                            

gct  ccc cac tcc atg gtg  gct gca ttt gac tac  aac ccc cag gag        6208
Ala  Pro His Ser Met Val  Ala Ala Phe Asp Tyr  Asn Pro Gln Glu            
1765                 1770                 1775                            

agt  tcc ccc aat atg gac  gtg gag gca gag ctg  ccc ttc cgg gca        6253
Ser  Ser Pro Asn Met Asp  Val Glu Ala Glu Leu  Pro Phe Arg Ala            
1780                 1785                 1790                            

ggg  gat gtc att act gtg  ttt ggg ggc atg gac  gat gac ggt ttc        6298
Gly  Asp Val Ile Thr Val  Phe Gly Gly Met Asp  Asp Asp Gly Phe            
1795                 1800                 1805                            

tac  tat ggg gaa tta aat  gga caa agg ggc ctg  gtt cca tcc aac        6343
Tyr  Tyr Gly Glu Leu Asn  Gly Gln Arg Gly Leu  Val Pro Ser Asn            
1810                 1815                 1820                            

ttc  ctg gag ggc cct ggg  cct gag gca ggc ggc  ctg gac agg gaa        6388
Phe  Leu Glu Gly Pro Gly  Pro Glu Ala Gly Gly  Leu Asp Arg Glu            
1825                 1830                 1835                            

ccc  agg aca ccc cag gct  gag agt cag aga acg  agg agg aga aga        6433
Pro  Arg Thr Pro Gln Ala  Glu Ser Gln Arg Thr  Arg Arg Arg Arg            
1840                 1845                 1850                            

gtc  cag tgc tag atggagatag atatatgtag agagagcaac atgactgggg          6485
Val  Gln Cys                                                              
1855                                                                      

ctgcaccaca caagggtccc cagggccccc aggtgggcct tgtaccccca gctctggcag     6545

cgcccccagg attgaacgtg gggagcccca gggcagaagc gagaaggtgt ggggtttctt     6605

ctccaagggg aagcagctcc tcaggaggct gggctctggg aagaaggagt gaagctgtgg     6665

cccatcctgc aggcagaaga ggccctgaga ggcccccaga tcactgtctc tgctgagcag     6725

ggaaggctca gactgggccc agagcccccg ttcttctgcg ttaacactgt ggcattcaga     6785

gggaatcaaa gagccttggt gaaggtcaga gctaaatggc tccttaagga tgaactctct     6845

agagaagcac cttcctccta caggagggga aactgagccc acagtgagta tgtaacttga     6905

ccaaggtcac tgagccagga ctggacccag gaccctcgcg tcctggtcca cccacctcgt     6965

ctactagtgt cccacagtgc tgcgctagtc ccttctgcca cccttcccag tcccaggacg     7025

ggccctggag ggagaaagga gcctgtgccc cctgatggct ctggctgtcc tgatcctgtc     7085

ttccctcccc tgaaggaaag tttgcactgg attttattgg agccccatct ccccagcggg     7145

caggcgggcg gagcctgtat atatgtatat actcagtgcc tcagttcagc ttcctccacc     7205

tcgcttccac tgcacaggcc caggaaggag aaaggccaag ccaaagtggg ccccaccctg     7265

cccccgtcgt gctccatcct tccctgccgg ggcctgctgg cccctgtaag gtcccgcccc     7325

caaagaccct ggggccagcg gggccgaaag cggagttggg tttgccttat tttgctcatt     7385

ggattcaagt tcttttgcat agttttcttc taacccctgt tggagtccag gggctggaga     7445

aaaggacaga tttatgcagc tattttcata cattccctgt tcagagtggg gtaggggttc     7505

tccgccgtta cccgatccac tccatccccc accctctgag gggtgagtgt gtctttgcat     7565

gtttcctttg ctgtggtggg agatagtttg actgaacccc caccttgacc ttggtctcca     7625

ggggtgtgga atggtggggg aatttgttta aaaagacatt ttattataat aaagtctatt     7685

ttcacaaaaa aaaaaaaaaa a                                               7706


<210>  238
<211>  1857
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Glu Gln Leu Thr Thr Leu Pro Arg Pro Gly Asp Pro Gly Ala Met 
1               5                   10                  15      


Glu Pro Trp Ala Leu Pro Thr Trp His Ser Trp Thr Pro Gly Arg Gly 
            20                  25                  30          


Gly Glu Pro Ser Ser Ala Ala Pro Ser Ile Ala Asp Thr Pro Pro Ala 
        35                  40                  45              


Ala Leu Gln Leu Gln Glu Leu Arg Ser Glu Glu Ser Ser Lys Pro Lys 
    50                  55                  60                  


Gly Asp Gly Ser Ser Arg Pro Val Gly Gly Thr Asp Pro Glu Gly Ala 
65                  70                  75                  80  


Glu Ala Cys Leu Pro Ser Leu Gly Gln Gln Ala Ser Ser Ser Gly Pro 
                85                  90                  95      


Ala Cys Gln Arg Pro Glu Asp Glu Glu Val Glu Ala Phe Leu Lys Ala 
            100                 105                 110         


Lys Leu Asn Met Ser Phe Gly Asp Arg Pro Asn Leu Glu Leu Leu Arg 
        115                 120                 125             


Ala Leu Gly Glu Leu Arg Gln Arg Cys Ala Ile Leu Lys Glu Glu Asn 
    130                 135                 140                 


Gln Met Leu Arg Lys Ser Ser Phe Pro Glu Thr Glu Glu Lys Val Arg 
145                 150                 155                 160 


Arg Leu Lys Arg Lys Asn Ala Glu Leu Ala Val Ile Ala Lys Arg Leu 
                165                 170                 175     


Glu Glu Arg Ala Arg Lys Leu Gln Glu Thr Asn Leu Arg Val Val Ser 
            180                 185                 190         


Ala Pro Leu Pro Arg Pro Gly Thr Ser Leu Glu Leu Cys Arg Lys Ala 
        195                 200                 205             


Leu Ala Arg Gln Arg Ala Arg Asp Leu Ser Glu Thr Ala Ser Ala Leu 
    210                 215                 220                 


Leu Ala Lys Asp Lys Gln Ile Ala Ala Leu Gln Arg Glu Cys Arg Glu 
225                 230                 235                 240 


Leu Gln Ala Arg Leu Thr Leu Val Gly Lys Glu Gly Pro Gln Trp Leu 
                245                 250                 255     


His Val Arg Asp Phe Asp Arg Leu Leu Arg Glu Ser Gln Arg Glu Val 
            260                 265                 270         


Leu Arg Leu Gln Arg Gln Ile Ala Leu Arg Asn Gln Arg Glu Thr Leu 
        275                 280                 285             


Pro Leu Pro Pro Ser Trp Pro Pro Gly Pro Ala Leu Gln Ala Arg Ala 
    290                 295                 300                 


Gly Ala Pro Ala Pro Gly Ala Pro Gly Glu Ala Thr Pro Gln Glu Asp 
305                 310                 315                 320 


Ala Asp Asn Leu Pro Val Ile Leu Gly Glu Pro Glu Lys Glu Gln Arg 
                325                 330                 335     


Val Gln Gln Leu Glu Ser Glu Leu Ser Lys Lys Arg Lys Lys Cys Glu 
            340                 345                 350         


Ser Leu Glu Gln Glu Ala Arg Lys Lys Gln Arg Arg Cys Glu Glu Leu 
        355                 360                 365             


Glu Leu Gln Leu Arg Gln Ala Gln Asn Glu Asn Ala Arg Leu Val Glu 
    370                 375                 380                 


Glu Asn Ser Arg Leu Ser Gly Arg Ala Thr Glu Lys Glu Gln Val Glu 
385                 390                 395                 400 


Trp Glu Asn Ala Glu Leu Arg Gly Gln Leu Leu Gly Val Thr Gln Glu 
                405                 410                 415     


Arg Asp Ser Ala Leu Arg Lys Ser Gln Gly Leu Gln Ser Lys Leu Glu 
            420                 425                 430         


Ser Leu Glu Gln Val Leu Lys His Met Arg Glu Val Ala Gln Arg Arg 
        435                 440                 445             


Gln Gln Leu Glu Val Glu His Glu Gln Ala Arg Leu Ser Leu Arg Glu 
    450                 455                 460                 


Lys Gln Glu Glu Val Arg Arg Leu Gln Gln Ala Gln Ala Glu Ala Gln 
465                 470                 475                 480 


Arg Glu His Glu Gly Ala Val Gln Leu Leu Glu Ser Thr Leu Asp Ser 
                485                 490                 495     


Met Gln Ala Arg Val Arg Glu Leu Glu Glu Gln Cys Arg Ser Gln Thr 
            500                 505                 510         


Glu Gln Phe Ser Leu Leu Ala Gln Glu Leu Gln Ala Phe Arg Leu His 
        515                 520                 525             


Pro Gly Pro Leu Asp Leu Leu Thr Ser Ala Leu Asp Cys Gly Ser Leu 
    530                 535                 540                 


Gly Asp Cys Pro Pro Pro Pro Cys Cys Cys Ser Ile Pro Gln Pro Cys 
545                 550                 555                 560 


Arg Gly Ser Gly Pro Lys Asp Leu Asp Leu Pro Pro Gly Ser Pro Gly 
                565                 570                 575     


Arg Cys Thr Pro Lys Ser Ser Glu Pro Ala Pro Ala Thr Leu Thr Gly 
            580                 585                 590         


Val Pro Arg Arg Thr Ala Lys Lys Ala Glu Ser Leu Ser Asn Ser Ser 
        595                 600                 605             


His Ser Glu Ser Ile His Asn Ser Pro Lys Ser Cys Pro Thr Pro Glu 
    610                 615                 620                 


Val Asp Thr Ala Ser Glu Val Glu Glu Leu Glu Ala Asp Ser Val Ser 
625                 630                 635                 640 


Leu Leu Pro Ala Ala Pro Glu Gly Ser Arg Gly Gly Ala Arg Ile Gln 
                645                 650                 655     


Val Phe Leu Ala Arg Tyr Ser Tyr Asn Pro Phe Glu Gly Pro Asn Glu 
            660                 665                 670         


Asn Pro Glu Ala Glu Leu Pro Leu Thr Ala Gly Glu Tyr Ile Tyr Ile 
        675                 680                 685             


Tyr Gly Asn Met Asp Glu Asp Gly Phe Phe Glu Gly Glu Leu Met Asp 
    690                 695                 700                 


Gly Arg Arg Gly Leu Val Pro Ser Asn Phe Val Glu Arg Val Ser Asp 
705                 710                 715                 720 


Asp Asp Leu Leu Thr Ser Leu Pro Pro Glu Leu Ala Asp Leu Ser His 
                725                 730                 735     


Ser Ser Gly Pro Glu Leu Ser Phe Leu Ser Val Gly Gly Gly Gly Ser 
            740                 745                 750         


Ser Ser Gly Gly Gln Ser Ser Val Gly Arg Ser Gln Pro Arg Pro Glu 
        755                 760                 765             


Glu Glu Asp Ala Gly Asp Glu Leu Ser Leu Ser Pro Ser Pro Glu Gly 
    770                 775                 780                 


Leu Gly Glu Pro Pro Ala Val Pro Tyr Pro Arg Arg Leu Val Val Leu 
785                 790                 795                 800 


Lys Gln Leu Ala His Ser Val Val Leu Ala Trp Glu Pro Pro Pro Glu 
                805                 810                 815     


Gln Val Glu Leu His Gly Phe His Ile Cys Val Asn Gly Glu Leu Arg 
            820                 825                 830         


Gln Ala Leu Gly Pro Gly Ala Pro Pro Lys Ala Val Leu Glu Asn Leu 
        835                 840                 845             


Asp Leu Trp Ala Gly Pro Leu His Ile Ser Val Gln Ala Leu Thr Ser 
    850                 855                 860                 


Arg Gly Ser Ser Asp Pro Leu Arg Cys Cys Leu Ala Val Gly Ala Arg 
865                 870                 875                 880 


Ala Gly Val Val Pro Ser Gln Leu Arg Val His Arg Leu Thr Ala Thr 
                885                 890                 895     


Ser Ala Glu Ile Thr Trp Val Pro Gly Asn Ser Asn Leu Ala His Ala 
            900                 905                 910         


Ile Tyr Leu Asn Gly Glu Glu Cys Pro Pro Ala Ser Pro Ser Thr Tyr 
        915                 920                 925             


Trp Ala Thr Phe Cys His Leu Arg Pro Gly Thr Pro Tyr Gln Ala Gln 
    930                 935                 940                 


Val Glu Ala Gln Leu Pro Pro Gln Gly Pro Trp Glu Pro Gly Trp Glu 
945                 950                 955                 960 


Arg Leu Glu Gln Arg Ala Ala Thr Leu Gln Phe Thr Thr Leu Pro Ala 
                965                 970                 975     


Gly Pro Pro Asp Ala Pro Leu Asp Val Gln Ile Glu Pro Gly Pro Ser 
            980                 985                 990         


Pro Gly Ile Leu Ile Ile Ser Trp  Leu Pro Val Thr Ile  Asp Ala Ala 
        995                 1000                 1005             


Gly Thr  Ser Asn Gly Val Arg  Val Thr Gly Tyr Ala  Ile Tyr Ala 
    1010                 1015                 1020             


Asp Gly  Gln Lys Ile Met Glu  Val Ala Ser Pro Thr  Ala Gly Ser 
    1025                 1030                 1035             


Val Leu  Val Glu Leu Ser Gln  Leu Gln Leu Leu Gln  Val Cys Arg 
    1040                 1045                 1050             


Glu Val  Val Val Arg Thr Met  Ser Pro His Gly Glu  Ser Ala Asp 
    1055                 1060                 1065             


Ser Ile  Pro Ala Pro Ile Thr  Pro Ala Leu Ala Pro  Ala Ser Leu 
    1070                 1075                 1080             


Pro Ala  Arg Val Ser Cys Pro  Ser Pro His Pro Ser  Pro Glu Ala 
    1085                 1090                 1095             


Arg Ala  Pro Leu Ala Ser Ala  Ser Pro Gly Pro Gly  Asp Pro Ser 
    1100                 1105                 1110             


Ser Pro  Leu Gln His Pro Ala  Pro Leu Gly Thr Gln  Glu Pro Pro 
    1115                 1120                 1125             


Gly Ala  Pro Pro Ala Ser Pro  Ser Arg Glu Met Ala  Lys Gly Ser 
    1130                 1135                 1140             


His Glu  Asp Pro Pro Ala Pro  Cys Ser Gln Glu Glu  Ala Gly Ala 
    1145                 1150                 1155             


Ala Val  Leu Gly Thr Ser Glu  Glu Arg Thr Ala Ser  Thr Ser Thr 
    1160                 1165                 1170             


Leu Gly  Glu Lys Asp Pro Gly  Pro Ala Ala Pro Ser  Leu Ala Lys 
    1175                 1180                 1185             


Gln Glu  Ala Glu Trp Thr Ala  Gly Glu Ala Cys Pro  Ala Ser Ser 
    1190                 1195                 1200             


Ser Thr  Gln Gly Ala Arg Ala  Gln Gln Ala Pro Asn  Thr Glu Met 
    1205                 1210                 1215             


Cys Gln  Gly Gly Asp Pro Gly  Ser Gly Leu Arg Pro  Arg Ala Glu 
    1220                 1225                 1230             


Lys Glu  Asp Thr Ala Glu Leu  Gly Val His Leu Val  Asn Ser Leu 
    1235                 1240                 1245             


Val Asp  His Gly Arg Asn Ser  Asp Leu Ser Asp Ile  Gln Glu Glu 
    1250                 1255                 1260             


Glu Glu  Glu Glu Glu Glu Glu  Glu Glu Glu Glu Leu  Gly Ser Arg 
    1265                 1270                 1275             


Thr Cys  Ser Phe Gln Lys Gln  Val Ala Gly Asn Ser  Ile Arg Glu 
    1280                 1285                 1290             


Asn Gly  Ala Lys Ser Gln Pro  Asp Pro Phe Cys Glu  Thr Asp Ser 
    1295                 1300                 1305             


Asp Glu  Glu Ile Leu Glu Gln  Ile Leu Glu Leu Pro  Leu Gln Gln 
    1310                 1315                 1320             


Phe Cys  Ser Lys Lys Leu Phe  Ser Ile Pro Glu Glu  Glu Glu Glu 
    1325                 1330                 1335             


Glu Glu  Glu Asp Glu Glu Glu  Glu Lys Ser Gly Ala  Gly Cys Ser 
    1340                 1345                 1350             


Ser Arg  Asp Pro Gly Pro Pro  Glu Pro Ala Leu Leu  Gly Leu Gly 
    1355                 1360                 1365             


Cys Asp  Ser Gly Gln Pro Arg  Arg Pro Gly Gln Cys  Pro Leu Ser 
    1370                 1375                 1380             


Pro Glu  Ser Ser Arg Ala Gly  Asp Cys Leu Glu Asp  Met Pro Gly 
    1385                 1390                 1395             


Leu Val  Gly Gly Ser Ser Arg  Arg Arg Gly Gly Gly  Ser Pro Glu 
    1400                 1405                 1410             


Lys Pro  Pro Ser Arg Arg Arg  Pro Pro Asp Pro Arg  Glu His Cys 
    1415                 1420                 1425             


Ser Arg  Leu Leu Ser Asn Asn  Gly Pro Gln Ala Ser  Gly Arg Leu 
    1430                 1435                 1440             


Gly Pro  Thr Arg Glu Arg Gly  Gly Leu Pro Val Ile  Glu Gly Pro 
    1445                 1450                 1455             


Arg Thr  Gly Leu Glu Ala Ser  Gly Arg Gly Arg Leu  Gly Pro Ser 
    1460                 1465                 1470             


Arg Arg  Cys Ser Arg Gly Arg  Ala Leu Glu Pro Gly  Leu Ala Ser 
    1475                 1480                 1485             


Cys Leu  Ser Pro Lys Cys Leu  Glu Ile Ser Ile Glu  Tyr Asp Ser 
    1490                 1495                 1500             


Glu Asp  Glu Gln Glu Ala Gly  Ser Gly Gly Ile Ser  Ile Thr Ser 
    1505                 1510                 1515             


Ser Cys  Tyr Pro Gly Asp Gly  Glu Ala Trp Gly Thr  Ala Thr Val 
    1520                 1525                 1530             


Gly Arg  Pro Arg Gly Pro Pro  Lys Ala Asn Ser Gly  Pro Lys Pro 
    1535                 1540                 1545             


Tyr Pro  Arg Leu Pro Ala Trp  Glu Lys Gly Glu Pro  Glu Arg Arg 
    1550                 1555                 1560             


Gly Arg  Ser Ala Thr Gly Arg  Ala Lys Glu Pro Leu  Ser Arg Ala 
    1565                 1570                 1575             


Thr Glu  Thr Gly Glu Ala Arg  Gly Gln Asp Gly Ser  Gly Arg Arg 
    1580                 1585                 1590             


Gly Pro  Gln Lys Arg Gly Val  Arg Val Leu Arg Pro  Ser Thr Ala 
    1595                 1600                 1605             


Glu Leu  Val Pro Ala Arg Ser  Pro Ser Glu Thr Leu  Ala Tyr Gln 
    1610                 1615                 1620             


His Leu  Pro Val Arg Ile Phe  Val Ala Leu Phe Asp  Tyr Asp Pro 
    1625                 1630                 1635             


Val Ser  Met Ser Pro Asn Pro  Asp Ala Gly Glu Glu  Glu Leu Pro 
    1640                 1645                 1650             


Phe Arg  Glu Gly Gln Ile Leu  Lys Val Phe Gly Asp  Lys Asp Ala 
    1655                 1660                 1665             


Asp Gly  Phe Tyr Gln Gly Glu  Gly Gly Gly Arg Thr  Gly Tyr Ile 
    1670                 1675                 1680             


Pro Cys  Asn Met Val Ala Glu  Val Ala Val Asp Ser  Pro Ala Gly 
    1685                 1690                 1695             


Arg Gln  Gln Leu Leu Gln Arg  Gly Tyr Leu Ser Pro  Asp Ile Leu 
    1700                 1705                 1710             


Leu Glu  Gly Ser Gly Asn Gly  Pro Phe Val Tyr Ser  Thr Ala His 
    1715                 1720                 1725             


Thr Thr  Gly Pro Pro Pro Lys  Pro Arg Arg Ser Lys  Lys Ala Glu 
    1730                 1735                 1740             


Ser Glu  Gly Pro Ala Gln Pro  Cys Pro Gly Pro Pro  Lys Leu Val 
    1745                 1750                 1755             


Pro Ser  Ala Asp Leu Lys Ala  Pro His Ser Met Val  Ala Ala Phe 
    1760                 1765                 1770             


Asp Tyr  Asn Pro Gln Glu Ser  Ser Pro Asn Met Asp  Val Glu Ala 
    1775                 1780                 1785             


Glu Leu  Pro Phe Arg Ala Gly  Asp Val Ile Thr Val  Phe Gly Gly 
    1790                 1795                 1800             


Met Asp  Asp Asp Gly Phe Tyr  Tyr Gly Glu Leu Asn  Gly Gln Arg 
    1805                 1810                 1815             


Gly Leu  Val Pro Ser Asn Phe  Leu Glu Gly Pro Gly  Pro Glu Ala 
    1820                 1825                 1830             


Gly Gly  Leu Asp Arg Glu Pro  Arg Thr Pro Gln Ala  Glu Ser Gln 
    1835                 1840                 1845             


Arg Thr  Arg Arg Arg Arg Val  Gln Cys 
    1850                 1855         


<210>  239
<211>  2447
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (889)..(1521)

<400>  239
ctactcatgg cgcctgccct ggttggcgat gtgttaccaa cgtctggcct gtcccagccc       60

aaggctccgc gtggcgacca ggcccagcac tgggaggctg tgcagagcgt ggcgtttact      120

gcttattgct actctgcaga ggttggcaac atctgacccg ctctactggc aggaaacagg      180

ctcgggggca ttgggaaaac gatcaaggcc acttggctgg acactggcgg agcctcgcac      240

tcaaacctgt cgggcctcaa ctccgtgcca ggccaacaag ttgccctggg cagttcaagc      300

tggggataag ggggatgggg agcaggaaga cagcagcaag gatgcgatcc cgaaggaact      360

ttcctcctca gactgctcca tgtccatgtg gggcaggtcg ctgaagagtt cgaaaccgtg      420

ctcagcaccg cgtttggggc atgtgagacc gagaggcttt gggaaactga cgccgctgtg      480

agaacgagtt tagcggagtc tatggacgct gcgagcttgt ggccacaaga gggcgccccg      540

gagcacggcc cagtccccgc ccccgctgga tggggcccgg cctcttccca gcgttcctcc      600

tccggcccca ggtcaccgcc agcacgcgcc tgcttcccgt ctgcgcgagt ccacgcagct      660

ccccagatca agaagctgag gccccaggtt acacactaaa gtaaatggca gaggcagaaa      720

taacacctat gtcctcctga ccccaaggca tgttcttaaa gttctggaaa cctcctggag      780

gcttccttgc tgctcctctg ggactgccac cctgggcagg gtgttctgtg gcccctcatc      840

atcgtggttt tgaaccacag gcccttcacc agcacagcag cagcaggc atg gca gca       897
                                                     Met Ala Ala          
                                                     1                    

agc gtg gag cag cgc gag ggc acc atc cag gtg cag ggc cag gcc ctc        945
Ser Val Glu Gln Arg Glu Gly Thr Ile Gln Val Gln Gly Gln Ala Leu           
    5                   10                  15                            

ttc ttc cga gag gcc ctg ccc ggc agt ggg cag gct cgc ttc tct gta        993
Phe Phe Arg Glu Ala Leu Pro Gly Ser Gly Gln Ala Arg Phe Ser Val           
20                  25                  30                  35            

ctg ctg ctg cat ggt att cgc ttc tcc tcc gag acc tgg cag aac ctg       1041
Leu Leu Leu His Gly Ile Arg Phe Ser Ser Glu Thr Trp Gln Asn Leu           
                40                  45                  50                

ggt aca ctg cac agg ctg gcc cag gct ggc tac cgg gct gtg gcc att       1089
Gly Thr Leu His Arg Leu Ala Gln Ala Gly Tyr Arg Ala Val Ala Ile           
            55                  60                  65                    

gac ctg cca ggt ctg ggg cac tcc aag gaa gca gca gcc cct gcc cct       1137
Asp Leu Pro Gly Leu Gly His Ser Lys Glu Ala Ala Ala Pro Ala Pro           
        70                  75                  80                        

att ggg gag ctg gcc cct ggc agc ttc ctg gcg gct gtg gtg gat gcc       1185
Ile Gly Glu Leu Ala Pro Gly Ser Phe Leu Ala Ala Val Val Asp Ala           
    85                  90                  95                            

ttg gag ctg ggc ccc ccg gtt gtg atc agt cca tca ctg agt ggc atg       1233
Leu Glu Leu Gly Pro Pro Val Val Ile Ser Pro Ser Leu Ser Gly Met           
100                 105                 110                 115           

tac tcc ctg ccc ttc ctc acg gcc cct ggc tcc cag ctc ccg ggc ttt       1281
Tyr Ser Leu Pro Phe Leu Thr Ala Pro Gly Ser Gln Leu Pro Gly Phe           
                120                 125                 130               

gtg cca gtg gcc ccc atc tgc act gac aaa atc aat gct gcc aac tat       1329
Val Pro Val Ala Pro Ile Cys Thr Asp Lys Ile Asn Ala Ala Asn Tyr           
            135                 140                 145                   

gcc agt gtg aag act cca gct ctg att gta tat gga gac cag gac ccc       1377
Ala Ser Val Lys Thr Pro Ala Leu Ile Val Tyr Gly Asp Gln Asp Pro           
        150                 155                 160                       

atg ggt cag acc agc ttt gag cac ctg aag cag ctg ccc aac cac cgg       1425
Met Gly Gln Thr Ser Phe Glu His Leu Lys Gln Leu Pro Asn His Arg           
    165                 170                 175                           

gtg ctg atc atg aag ggg gcg ggg cac ccc tgt tac ctg gac aaa cca       1473
Val Leu Ile Met Lys Gly Ala Gly His Pro Cys Tyr Leu Asp Lys Pro           
180                 185                 190                 195           

gag gag tgg cat aca ggg ctg ctg gac ttc ctg cag ggg ctc cag tga       1521
Glu Glu Trp His Thr Gly Leu Leu Asp Phe Leu Gln Gly Leu Gln               
                200                 205                 210               

agcccagcac tgctgcaggg ggtgggctgc ctgcctgctc tgagctctct cttgcacgct     1581

ctctcttctc tcccaggctc tggctcatgc acatgcaaca ggtgcgtctg tctatatgtc     1641

tgggttcttg tcttttgtgg tctgtttgtc ttttctacct ctttctcttg cagtgataga     1701

ctgagggggt aaaatcaaga gaaaaaactc tcaggaatca aggaacataa tcctgtggag     1761

ggtaatccat tacatgagct tctcctgttc ttccactttc ctgcctggct ttcactcctt     1821

cccctgctct gcccagcctt tccctcccac ccactcctcc ttctgcaaat gccctgaagg     1881

ccagccctta ccccaacacc cacttcccca cctccttagg ccccagatac atacatgccc     1941

acatgcacgc ttacatgttt agagccatcc ttgtttccaa atatgaccct tcgcttgagg     2001

gcaactgcat aggtacatct aactctggac tggcatgcac attgtcatgt gcagctttgc     2061

atatacacac atgcatacat gagcctccac acaagcactt gcacacatgt ggactcctaa     2121

ccatgctaac ctcactggct gggaaggtgg ggaccccatg ggccagccct tgcaggaggc     2181

ccttttgcaa ggcttagggt gtggccagcc ctgaaagcta cttggacaca ggtttcagct     2241

ggccccagcc cagaagtgac ccccagaaag ggagggccac cgctttgccc cctgctttta     2301

cccttccttc tgggtgctct acacctcagg ttaccaggcc tgaggcatct cagccaagct     2361

tgtttcctgc tctgaggctt gtggggtggg agccagagtg gaggtcggtg aaataaagtg     2421

atgcaattag accccaaaaa aaaaaa                                          2447


<210>  240
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Ala Ala Ser Val Glu Gln Arg Glu Gly Thr Ile Gln Val Gln Gly 
1               5                   10                  15      


Gln Ala Leu Phe Phe Arg Glu Ala Leu Pro Gly Ser Gly Gln Ala Arg 
            20                  25                  30          


Phe Ser Val Leu Leu Leu His Gly Ile Arg Phe Ser Ser Glu Thr Trp 
        35                  40                  45              


Gln Asn Leu Gly Thr Leu His Arg Leu Ala Gln Ala Gly Tyr Arg Ala 
    50                  55                  60                  


Val Ala Ile Asp Leu Pro Gly Leu Gly His Ser Lys Glu Ala Ala Ala 
65                  70                  75                  80  


Pro Ala Pro Ile Gly Glu Leu Ala Pro Gly Ser Phe Leu Ala Ala Val 
                85                  90                  95      


Val Asp Ala Leu Glu Leu Gly Pro Pro Val Val Ile Ser Pro Ser Leu 
            100                 105                 110         


Ser Gly Met Tyr Ser Leu Pro Phe Leu Thr Ala Pro Gly Ser Gln Leu 
        115                 120                 125             


Pro Gly Phe Val Pro Val Ala Pro Ile Cys Thr Asp Lys Ile Asn Ala 
    130                 135                 140                 


Ala Asn Tyr Ala Ser Val Lys Thr Pro Ala Leu Ile Val Tyr Gly Asp 
145                 150                 155                 160 


Gln Asp Pro Met Gly Gln Thr Ser Phe Glu His Leu Lys Gln Leu Pro 
                165                 170                 175     


Asn His Arg Val Leu Ile Met Lys Gly Ala Gly His Pro Cys Tyr Leu 
            180                 185                 190         


Asp Lys Pro Glu Glu Trp His Thr Gly Leu Leu Asp Phe Leu Gln Gly 
        195                 200                 205             


Leu Gln 
    210 


<210>  241
<211>  3606
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (211)..(3015)

<400>  241
aacatttatt ttgacaaccc tctaggtgtt gctaggcttc tgggatatga cagcattgcc       60

ttgtgttagc tagcaataag aaaagaagct ttgtttggat taacatatat accctcttca      120

ttctgcatac ctattttttc cccaataatt tgcagcttag gtccgaggac accacaaact      180

ctgcttaaag ggcctggagg ctctcaaggc atg gcc aga cgc tct gtc ttg tac       234
                                 Met Ala Arg Arg Ser Val Leu Tyr          
                                 1               5                        

ttc atc ctg ctg aat gct ctg atc aac aag ggc caa gcc tgc ttc tgt        282
Phe Ile Leu Leu Asn Ala Leu Ile Asn Lys Gly Gln Ala Cys Phe Cys           
    10                  15                  20                            

gat cac tat gca tgg act cag tgg acc agc tgc tca aaa act tgc aat        330
Asp His Tyr Ala Trp Thr Gln Trp Thr Ser Cys Ser Lys Thr Cys Asn           
25                  30                  35                  40            

tct gga acc cag agc aga cac aga caa ata gta gta gat aag tac tac        378
Ser Gly Thr Gln Ser Arg His Arg Gln Ile Val Val Asp Lys Tyr Tyr           
                45                  50                  55                

cag gaa aac ttt tgt gaa cag att tgc agc aag cag gag act aga gaa        426
Gln Glu Asn Phe Cys Glu Gln Ile Cys Ser Lys Gln Glu Thr Arg Glu           
            60                  65                  70                    

tgt aac tgg caa aga tgc ccc atc aac tgc ctc ctg gga gat ttt gga        474
Cys Asn Trp Gln Arg Cys Pro Ile Asn Cys Leu Leu Gly Asp Phe Gly           
        75                  80                  85                        

cca tgg tca gac tgt gac cct tgt att gaa aaa cag tct aaa gtt aga        522
Pro Trp Ser Asp Cys Asp Pro Cys Ile Glu Lys Gln Ser Lys Val Arg           
    90                  95                  100                           

tct gtc ttg cgt ccc agt cag ttt ggg gga cag cca tgc act gcg cct        570
Ser Val Leu Arg Pro Ser Gln Phe Gly Gly Gln Pro Cys Thr Ala Pro           
105                 110                 115                 120           

ctg gta gcc ttt caa cca tgc att cca tct aag ctc tgc aaa att gaa        618
Leu Val Ala Phe Gln Pro Cys Ile Pro Ser Lys Leu Cys Lys Ile Glu           
                125                 130                 135               

gag gct gac tgc aag aat aaa ttt cgc tgt gac agt ggc cgc tgc att        666
Glu Ala Asp Cys Lys Asn Lys Phe Arg Cys Asp Ser Gly Arg Cys Ile           
            140                 145                 150                   

gcc aga aag tta gaa tgc aat gga gaa aat gac tgt gga gac aat tca        714
Ala Arg Lys Leu Glu Cys Asn Gly Glu Asn Asp Cys Gly Asp Asn Ser           
        155                 160                 165                       

gat gaa agg gac tgt ggg agg aca aag gca gta tgc aca cgg aag tat        762
Asp Glu Arg Asp Cys Gly Arg Thr Lys Ala Val Cys Thr Arg Lys Tyr           
    170                 175                 180                           

aat ccc atc cct agt gta cag ttg atg ggc aat ggg ttt cat ttt ctg        810
Asn Pro Ile Pro Ser Val Gln Leu Met Gly Asn Gly Phe His Phe Leu           
185                 190                 195                 200           

gca gga gag ccc aga gga gaa gtc ctt gat aac tct ttc act gga gga        858
Ala Gly Glu Pro Arg Gly Glu Val Leu Asp Asn Ser Phe Thr Gly Gly           
                205                 210                 215               

ata tgt aaa act gtc aaa agc agt agg aca agt aat cca tac cgt gtt        906
Ile Cys Lys Thr Val Lys Ser Ser Arg Thr Ser Asn Pro Tyr Arg Val           
            220                 225                 230                   

ccg gcc aat ctg gaa aat gtc ggc ttt gag gta caa act gca gaa gat        954
Pro Ala Asn Leu Glu Asn Val Gly Phe Glu Val Gln Thr Ala Glu Asp           
        235                 240                 245                       

gac ttg aaa aca gat ttc tac aag gat tta act tct ctt gga cac aat       1002
Asp Leu Lys Thr Asp Phe Tyr Lys Asp Leu Thr Ser Leu Gly His Asn           
    250                 255                 260                           

gaa aat caa caa ggc tca ttc tca agt cag ggg ggg agc tct ttc agt       1050
Glu Asn Gln Gln Gly Ser Phe Ser Ser Gln Gly Gly Ser Ser Phe Ser           
265                 270                 275                 280           

gta cca att ttt tat tcc tca aag aga agt gaa aat atc aac cat aat       1098
Val Pro Ile Phe Tyr Ser Ser Lys Arg Ser Glu Asn Ile Asn His Asn           
                285                 290                 295               

tct gcc ttc aaa caa gcc att caa gcc tct cac aaa aag gat tct agt       1146
Ser Ala Phe Lys Gln Ala Ile Gln Ala Ser His Lys Lys Asp Ser Ser           
            300                 305                 310                   

ttt att agg atc cat aaa gtg atg aaa gtc tta aac ttc aca acg aaa       1194
Phe Ile Arg Ile His Lys Val Met Lys Val Leu Asn Phe Thr Thr Lys           
        315                 320                 325                       

gct aaa gat ctg cac ctt tct gat gtc ttt ttg aaa gca ctt aac cat       1242
Ala Lys Asp Leu His Leu Ser Asp Val Phe Leu Lys Ala Leu Asn His           
    330                 335                 340                           

ctg cct cta gaa tac aac tct gct ttg tac agc cga ata ttc gat gac       1290
Leu Pro Leu Glu Tyr Asn Ser Ala Leu Tyr Ser Arg Ile Phe Asp Asp           
345                 350                 355                 360           

ttt ggg act cat tac ttc acc tct ggc tcc ctg gga ggc gtg tat gac       1338
Phe Gly Thr His Tyr Phe Thr Ser Gly Ser Leu Gly Gly Val Tyr Asp           
                365                 370                 375               

ctt ctc tat cag ttt agc agt gag gaa cta aag aac tca ggt tta acc       1386
Leu Leu Tyr Gln Phe Ser Ser Glu Glu Leu Lys Asn Ser Gly Leu Thr           
            380                 385                 390                   

gag gaa gaa gcc aaa cac tgt gtc agg att gaa aca aag aaa cgc gtt       1434
Glu Glu Glu Ala Lys His Cys Val Arg Ile Glu Thr Lys Lys Arg Val           
        395                 400                 405                       

tta ttt gct aag aaa aca aaa gtg gaa cat agg tgc acc acc aac aag       1482
Leu Phe Ala Lys Lys Thr Lys Val Glu His Arg Cys Thr Thr Asn Lys           
    410                 415                 420                           

ctg tca gag aaa cat gaa ggt tca ttt ata cag gga gca gag aaa tcc       1530
Leu Ser Glu Lys His Glu Gly Ser Phe Ile Gln Gly Ala Glu Lys Ser           
425                 430                 435                 440           

ata tcc ctg att cga ggt gga agg agt gaa tat gga gca gct ttg gca       1578
Ile Ser Leu Ile Arg Gly Gly Arg Ser Glu Tyr Gly Ala Ala Leu Ala           
                445                 450                 455               

tgg gag aaa ggg agc tct ggt ctg gag gag aag aca ttt tct gag tgg       1626
Trp Glu Lys Gly Ser Ser Gly Leu Glu Glu Lys Thr Phe Ser Glu Trp           
            460                 465                 470                   

tta gaa tca gtg aag gaa aat cct gct gtg att gac ttt gag ctt gcc       1674
Leu Glu Ser Val Lys Glu Asn Pro Ala Val Ile Asp Phe Glu Leu Ala           
        475                 480                 485                       

ccc atc gtg gac ttg gta aga aac atc ccc tgt gca gtg aca aaa cgg       1722
Pro Ile Val Asp Leu Val Arg Asn Ile Pro Cys Ala Val Thr Lys Arg           
    490                 495                 500                           

aac aac ctc agg aaa gct ttg caa gag tat gca gcc aag ttc gat cct       1770
Asn Asn Leu Arg Lys Ala Leu Gln Glu Tyr Ala Ala Lys Phe Asp Pro           
505                 510                 515                 520           

tgc cag tgt gct cca tgc cct aat aat ggc cga ccc acc ctc tca ggg       1818
Cys Gln Cys Ala Pro Cys Pro Asn Asn Gly Arg Pro Thr Leu Ser Gly           
                525                 530                 535               

act gaa tgt ctg tgt gtg tgt cag agt ggc acc tat ggt gag aac tgt       1866
Thr Glu Cys Leu Cys Val Cys Gln Ser Gly Thr Tyr Gly Glu Asn Cys           
            540                 545                 550                   

gag aaa cag tct cca gat tat aaa tcc aat gca gta gac gga cag tgg       1914
Glu Lys Gln Ser Pro Asp Tyr Lys Ser Asn Ala Val Asp Gly Gln Trp           
        555                 560                 565                       

ggt tgt tgg tct tcc tgg agt acc tgt gat gct act tat aag aga tcg       1962
Gly Cys Trp Ser Ser Trp Ser Thr Cys Asp Ala Thr Tyr Lys Arg Ser           
    570                 575                 580                           

aga acc cga gaa tgc aat aat cct gcc ccc caa cga gga ggg aaa cgc       2010
Arg Thr Arg Glu Cys Asn Asn Pro Ala Pro Gln Arg Gly Gly Lys Arg           
585                 590                 595                 600           

tgt gag ggg gag aag cga caa gag gaa gac tgc aca ttt tca atc atg       2058
Cys Glu Gly Glu Lys Arg Gln Glu Glu Asp Cys Thr Phe Ser Ile Met           
                605                 610                 615               

gaa aac aat gga caa cca tgt atc aat gat gat gaa gaa atg aaa gag       2106
Glu Asn Asn Gly Gln Pro Cys Ile Asn Asp Asp Glu Glu Met Lys Glu           
            620                 625                 630                   

gtc gat ctt cct gag ata gaa gca gat tcc ggg tgt cct cag cca gtt       2154
Val Asp Leu Pro Glu Ile Glu Ala Asp Ser Gly Cys Pro Gln Pro Val           
        635                 640                 645                       

cct cca gaa aat gga ttt atc cgg aat gaa aag caa cta tac ttg gtt       2202
Pro Pro Glu Asn Gly Phe Ile Arg Asn Glu Lys Gln Leu Tyr Leu Val           
    650                 655                 660                           

gga gaa gat gtt gaa att tca tgc ctt act ggc ttt gaa act gtt gga       2250
Gly Glu Asp Val Glu Ile Ser Cys Leu Thr Gly Phe Glu Thr Val Gly           
665                 670                 675                 680           

tac cag tac ttc aga tgc tta cca gac ggg acc tgg aga caa ggg gat       2298
Tyr Gln Tyr Phe Arg Cys Leu Pro Asp Gly Thr Trp Arg Gln Gly Asp           
                685                 690                 695               

gtg gaa tgc caa cgg acg gag tgc atc aag cca gtt gtg cag gaa gtc       2346
Val Glu Cys Gln Arg Thr Glu Cys Ile Lys Pro Val Val Gln Glu Val           
            700                 705                 710                   

ctg aca att aca cca ttt cag aga ttg tat aga att ggt gaa tcc att       2394
Leu Thr Ile Thr Pro Phe Gln Arg Leu Tyr Arg Ile Gly Glu Ser Ile           
        715                 720                 725                       

gag cta act tgc ccc aaa ggc ttt gtt gtt gct ggg cca tca agg tac       2442
Glu Leu Thr Cys Pro Lys Gly Phe Val Val Ala Gly Pro Ser Arg Tyr           
    730                 735                 740                           

aca tgc cag ggg aat tcc tgg aca cca ccc att tca aac tct ctc acc       2490
Thr Cys Gln Gly Asn Ser Trp Thr Pro Pro Ile Ser Asn Ser Leu Thr           
745                 750                 755                 760           

tgt gaa aaa gat act cta aca aaa tta aaa ggc cat tgt cag ctg gga       2538
Cys Glu Lys Asp Thr Leu Thr Lys Leu Lys Gly His Cys Gln Leu Gly           
                765                 770                 775               

cag aaa caa tca gga tct gaa tgc att tgt atg tct cca gaa gaa gac       2586
Gln Lys Gln Ser Gly Ser Glu Cys Ile Cys Met Ser Pro Glu Glu Asp           
            780                 785                 790                   

tgt agc cat cat tca gaa gat ctc tgt gtg ttt gac aca gac tcc aac       2634
Cys Ser His His Ser Glu Asp Leu Cys Val Phe Asp Thr Asp Ser Asn           
        795                 800                 805                       

gat tac ttt act tca ccc gct tgt aag ttt ttg gct gag aaa tgt tta       2682
Asp Tyr Phe Thr Ser Pro Ala Cys Lys Phe Leu Ala Glu Lys Cys Leu           
    810                 815                 820                           

aat aat cag caa ctc cat ttt cta cat att ggt tcc tgc caa gac ggc       2730
Asn Asn Gln Gln Leu His Phe Leu His Ile Gly Ser Cys Gln Asp Gly           
825                 830                 835                 840           

cgc cag tta gaa tgg ggt ctt gaa agg aca aga ctt tca tcc aac agc       2778
Arg Gln Leu Glu Trp Gly Leu Glu Arg Thr Arg Leu Ser Ser Asn Ser           
                845                 850                 855               

aca aag aaa gaa tcc tgt ggc tat gac acc tgc tat gac tgg gaa aaa       2826
Thr Lys Lys Glu Ser Cys Gly Tyr Asp Thr Cys Tyr Asp Trp Glu Lys           
            860                 865                 870                   

tgt tca gcc tcc act tcc aaa tgt gtc tgc cta ttg ccc cca cag tgc       2874
Cys Ser Ala Ser Thr Ser Lys Cys Val Cys Leu Leu Pro Pro Gln Cys           
        875                 880                 885                       

ttc aag ggt gga aac caa ctc tac tgt gtc aaa atg gga tca tca aca       2922
Phe Lys Gly Gly Asn Gln Leu Tyr Cys Val Lys Met Gly Ser Ser Thr           
    890                 895                 900                           

agt gag aaa aca ttg aac atc tgt gaa gtg gga act ata aga tgt gca       2970
Ser Glu Lys Thr Leu Asn Ile Cys Glu Val Gly Thr Ile Arg Cys Ala           
905                 910                 915                 920           

aac agg aag atg gaa ata ctg cat cct gga aag tgt ttg gcc tag           3015
Asn Arg Lys Met Glu Ile Leu His Pro Gly Lys Cys Leu Ala                   
                925                 930                                   

cacaattact gctaggccca gcacaatgaa cagatttacc atcccgaaga accaactcct     3075

acaaatgaga attcttgcac aaacagcaga ctggcatgct caaagttact gacaaaaatt     3135

attttctgtt agtttgagat cattattctc ccctgactct cctgtttggg catgtcttat     3195

tcagttccag ctcatgacgc cctgtagcat acccctaggt accaacttcc acagcagtct     3255

cgtaaattct cctgttcaca ttgtacaaaa ataatgtgac ttctgaggcc cttatgtagc     3315

ctgtgacatt aagcattctc gcaattagaa ataagaataa aacccataat tttcttcaat     3375

gagttaataa acagaaatct ccagaacctc tgaaacacat tcttgaagcc cagctttcat     3435

atcttcattc aacaaataat ttctgagtgt gtatacagga tgtcaagtac tgaccaaagt     3495

cctgagaact cggcagataa taaaacagac aaaagccttt gccttcatga agcatacatt     3555

cattcagggg tagacacaca aaaaatgaaa taaacaggta aaatatgtag c              3606


<210>  242
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Ala Arg Arg Ser Val Leu Tyr Phe Ile Leu Leu Asn Ala Leu Ile 
1               5                   10                  15      


Asn Lys Gly Gln Ala Cys Phe Cys Asp His Tyr Ala Trp Thr Gln Trp 
            20                  25                  30          


Thr Ser Cys Ser Lys Thr Cys Asn Ser Gly Thr Gln Ser Arg His Arg 
        35                  40                  45              


Gln Ile Val Val Asp Lys Tyr Tyr Gln Glu Asn Phe Cys Glu Gln Ile 
    50                  55                  60                  


Cys Ser Lys Gln Glu Thr Arg Glu Cys Asn Trp Gln Arg Cys Pro Ile 
65                  70                  75                  80  


Asn Cys Leu Leu Gly Asp Phe Gly Pro Trp Ser Asp Cys Asp Pro Cys 
                85                  90                  95      


Ile Glu Lys Gln Ser Lys Val Arg Ser Val Leu Arg Pro Ser Gln Phe 
            100                 105                 110         


Gly Gly Gln Pro Cys Thr Ala Pro Leu Val Ala Phe Gln Pro Cys Ile 
        115                 120                 125             


Pro Ser Lys Leu Cys Lys Ile Glu Glu Ala Asp Cys Lys Asn Lys Phe 
    130                 135                 140                 


Arg Cys Asp Ser Gly Arg Cys Ile Ala Arg Lys Leu Glu Cys Asn Gly 
145                 150                 155                 160 


Glu Asn Asp Cys Gly Asp Asn Ser Asp Glu Arg Asp Cys Gly Arg Thr 
                165                 170                 175     


Lys Ala Val Cys Thr Arg Lys Tyr Asn Pro Ile Pro Ser Val Gln Leu 
            180                 185                 190         


Met Gly Asn Gly Phe His Phe Leu Ala Gly Glu Pro Arg Gly Glu Val 
        195                 200                 205             


Leu Asp Asn Ser Phe Thr Gly Gly Ile Cys Lys Thr Val Lys Ser Ser 
    210                 215                 220                 


Arg Thr Ser Asn Pro Tyr Arg Val Pro Ala Asn Leu Glu Asn Val Gly 
225                 230                 235                 240 


Phe Glu Val Gln Thr Ala Glu Asp Asp Leu Lys Thr Asp Phe Tyr Lys 
                245                 250                 255     


Asp Leu Thr Ser Leu Gly His Asn Glu Asn Gln Gln Gly Ser Phe Ser 
            260                 265                 270         


Ser Gln Gly Gly Ser Ser Phe Ser Val Pro Ile Phe Tyr Ser Ser Lys 
        275                 280                 285             


Arg Ser Glu Asn Ile Asn His Asn Ser Ala Phe Lys Gln Ala Ile Gln 
    290                 295                 300                 


Ala Ser His Lys Lys Asp Ser Ser Phe Ile Arg Ile His Lys Val Met 
305                 310                 315                 320 


Lys Val Leu Asn Phe Thr Thr Lys Ala Lys Asp Leu His Leu Ser Asp 
                325                 330                 335     


Val Phe Leu Lys Ala Leu Asn His Leu Pro Leu Glu Tyr Asn Ser Ala 
            340                 345                 350         


Leu Tyr Ser Arg Ile Phe Asp Asp Phe Gly Thr His Tyr Phe Thr Ser 
        355                 360                 365             


Gly Ser Leu Gly Gly Val Tyr Asp Leu Leu Tyr Gln Phe Ser Ser Glu 
    370                 375                 380                 


Glu Leu Lys Asn Ser Gly Leu Thr Glu Glu Glu Ala Lys His Cys Val 
385                 390                 395                 400 


Arg Ile Glu Thr Lys Lys Arg Val Leu Phe Ala Lys Lys Thr Lys Val 
                405                 410                 415     


Glu His Arg Cys Thr Thr Asn Lys Leu Ser Glu Lys His Glu Gly Ser 
            420                 425                 430         


Phe Ile Gln Gly Ala Glu Lys Ser Ile Ser Leu Ile Arg Gly Gly Arg 
        435                 440                 445             


Ser Glu Tyr Gly Ala Ala Leu Ala Trp Glu Lys Gly Ser Ser Gly Leu 
    450                 455                 460                 


Glu Glu Lys Thr Phe Ser Glu Trp Leu Glu Ser Val Lys Glu Asn Pro 
465                 470                 475                 480 


Ala Val Ile Asp Phe Glu Leu Ala Pro Ile Val Asp Leu Val Arg Asn 
                485                 490                 495     


Ile Pro Cys Ala Val Thr Lys Arg Asn Asn Leu Arg Lys Ala Leu Gln 
            500                 505                 510         


Glu Tyr Ala Ala Lys Phe Asp Pro Cys Gln Cys Ala Pro Cys Pro Asn 
        515                 520                 525             


Asn Gly Arg Pro Thr Leu Ser Gly Thr Glu Cys Leu Cys Val Cys Gln 
    530                 535                 540                 


Ser Gly Thr Tyr Gly Glu Asn Cys Glu Lys Gln Ser Pro Asp Tyr Lys 
545                 550                 555                 560 


Ser Asn Ala Val Asp Gly Gln Trp Gly Cys Trp Ser Ser Trp Ser Thr 
                565                 570                 575     


Cys Asp Ala Thr Tyr Lys Arg Ser Arg Thr Arg Glu Cys Asn Asn Pro 
            580                 585                 590         


Ala Pro Gln Arg Gly Gly Lys Arg Cys Glu Gly Glu Lys Arg Gln Glu 
        595                 600                 605             


Glu Asp Cys Thr Phe Ser Ile Met Glu Asn Asn Gly Gln Pro Cys Ile 
    610                 615                 620                 


Asn Asp Asp Glu Glu Met Lys Glu Val Asp Leu Pro Glu Ile Glu Ala 
625                 630                 635                 640 


Asp Ser Gly Cys Pro Gln Pro Val Pro Pro Glu Asn Gly Phe Ile Arg 
                645                 650                 655     


Asn Glu Lys Gln Leu Tyr Leu Val Gly Glu Asp Val Glu Ile Ser Cys 
            660                 665                 670         


Leu Thr Gly Phe Glu Thr Val Gly Tyr Gln Tyr Phe Arg Cys Leu Pro 
        675                 680                 685             


Asp Gly Thr Trp Arg Gln Gly Asp Val Glu Cys Gln Arg Thr Glu Cys 
    690                 695                 700                 


Ile Lys Pro Val Val Gln Glu Val Leu Thr Ile Thr Pro Phe Gln Arg 
705                 710                 715                 720 


Leu Tyr Arg Ile Gly Glu Ser Ile Glu Leu Thr Cys Pro Lys Gly Phe 
                725                 730                 735     


Val Val Ala Gly Pro Ser Arg Tyr Thr Cys Gln Gly Asn Ser Trp Thr 
            740                 745                 750         


Pro Pro Ile Ser Asn Ser Leu Thr Cys Glu Lys Asp Thr Leu Thr Lys 
        755                 760                 765             


Leu Lys Gly His Cys Gln Leu Gly Gln Lys Gln Ser Gly Ser Glu Cys 
    770                 775                 780                 


Ile Cys Met Ser Pro Glu Glu Asp Cys Ser His His Ser Glu Asp Leu 
785                 790                 795                 800 


Cys Val Phe Asp Thr Asp Ser Asn Asp Tyr Phe Thr Ser Pro Ala Cys 
                805                 810                 815     


Lys Phe Leu Ala Glu Lys Cys Leu Asn Asn Gln Gln Leu His Phe Leu 
            820                 825                 830         


His Ile Gly Ser Cys Gln Asp Gly Arg Gln Leu Glu Trp Gly Leu Glu 
        835                 840                 845             


Arg Thr Arg Leu Ser Ser Asn Ser Thr Lys Lys Glu Ser Cys Gly Tyr 
    850                 855                 860                 


Asp Thr Cys Tyr Asp Trp Glu Lys Cys Ser Ala Ser Thr Ser Lys Cys 
865                 870                 875                 880 


Val Cys Leu Leu Pro Pro Gln Cys Phe Lys Gly Gly Asn Gln Leu Tyr 
                885                 890                 895     


Cys Val Lys Met Gly Ser Ser Thr Ser Glu Lys Thr Leu Asn Ile Cys 
            900                 905                 910         


Glu Val Gly Thr Ile Arg Cys Ala Asn Arg Lys Met Glu Ile Leu His 
        915                 920                 925             


Pro Gly Lys Cys Leu Ala 
    930                 


<210>  243
<211>  222
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(222)

<400>  243
atg agg att gct gtc ctc ttc ttc acc att ttc ttc ttt atg agc caa         48
Met Arg Ile Ala Val Leu Phe Phe Thr Ile Phe Phe Phe Met Ser Gln           
1               5                   10                  15                

gtt cta cca gcc aag ggc aaa ttc aag gag atc tgt gaa cgt cca aat         96
Val Leu Pro Ala Lys Gly Lys Phe Lys Glu Ile Cys Glu Arg Pro Asn           
            20                  25                  30                    

ggc tcc tgt cgg gac ttt tgc ctc gaa aca gaa atc cat gta ggg aga        144
Gly Ser Cys Arg Asp Phe Cys Leu Glu Thr Glu Ile His Val Gly Arg           
        35                  40                  45                        

tgt tta aat agc cga ccc tgc tgc ctg cct ctg ggg cat caa cca aga        192
Cys Leu Asn Ser Arg Pro Cys Cys Leu Pro Leu Gly His Gln Pro Arg           
    50                  55                  60                            

att gag agc act aca ccc aaa aag gac tga                                222
Ile Glu Ser Thr Thr Pro Lys Lys Asp                                       
65                  70                                                    


<210>  244
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Arg Ile Ala Val Leu Phe Phe Thr Ile Phe Phe Phe Met Ser Gln 
1               5                   10                  15      


Val Leu Pro Ala Lys Gly Lys Phe Lys Glu Ile Cys Glu Arg Pro Asn 
            20                  25                  30          


Gly Ser Cys Arg Asp Phe Cys Leu Glu Thr Glu Ile His Val Gly Arg 
        35                  40                  45              


Cys Leu Asn Ser Arg Pro Cys Cys Leu Pro Leu Gly His Gln Pro Arg 
    50                  55                  60                  


Ile Glu Ser Thr Thr Pro Lys Lys Asp 
65                  70              


<210>  245
<211>  1130
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(483)

<400>  245
atg gtt cta ctt ggt tgc atg tgg gtc aca aag gat ggc gcc gga gaa         48
Met Val Leu Leu Gly Cys Met Trp Val Thr Lys Asp Gly Ala Gly Glu           
1               5                   10                  15                

agg agc acc cgg cag cac cag ccc tgt ccc cat tct aca acg cct cct         96
Arg Ser Thr Arg Gln His Gln Pro Cys Pro His Ser Thr Thr Pro Pro           
            20                  25                  30                    

acc cct gtc ccc gcc gtc cgg gcc agg gag agg gca ctg agg gca gga        144
Thr Pro Val Pro Ala Val Arg Ala Arg Glu Arg Ala Leu Arg Ala Gly           
        35                  40                  45                        

ccc aaa gga agc acc tgg ttg ggc cgg gcc ggg aag cga agg ccc act        192
Pro Lys Gly Ser Thr Trp Leu Gly Arg Ala Gly Lys Arg Arg Pro Thr           
    50                  55                  60                            

cct cgg ctc cgg gga ggc ggc cac cac ggc ttc gct agc cgc gtc ccg        240
Pro Arg Leu Arg Gly Gly Gly His His Gly Phe Ala Ser Arg Val Pro           
65                  70                  75                  80            

agc cac gcc agc tgc agc cag ctg tgc gcg gct tgt tcg ggc ctg agc        288
Ser His Ala Ser Cys Ser Gln Leu Cys Ala Ala Cys Ser Gly Leu Ser           
                85                  90                  95                

tgg cgc tac gaa gtt ccg gtc cag gtc tct gac ttc ggg ctt gtt cgc        336
Trp Arg Tyr Glu Val Pro Val Gln Val Ser Asp Phe Gly Leu Val Arg           
            100                 105                 110                   

tgg tgg cgt cgg agc cga gcc gga ctg gtc agg atg atc acg gac gtg        384
Trp Trp Arg Arg Ser Arg Ala Gly Leu Val Arg Met Ile Thr Asp Val           
        115                 120                 125                       

cag ctc gcc atc ttc gcc aac atg ctg ggc gtg tcg ctc ttc ttg ctt        432
Gln Leu Ala Ile Phe Ala Asn Met Leu Gly Val Ser Leu Phe Leu Leu           
    130                 135                 140                           

gtc gtt ctc tat cac tac gtg gcc gtc aac aat ccc aag aag cag gaa        480
Val Val Leu Tyr His Tyr Val Ala Val Asn Asn Pro Lys Lys Gln Glu           
145                 150                 155                 160           

tga aagtggcgct ttctccgccc cagggttcca ggacatagtc tgaggcaaga             533

tggagggtat gaggggcctt cacacttcac ttcatccctt ctacccatca caacatacaa      593

agcaactaca cctggatttt tccaaacaac ttttatttcc tcagagtctt ccttaatcct      653

atggaacaag aagctgccac tgaatagggc ccagtatagg ggcttgcttt tctactccct      713

ccccccaata taaaaatata gacttttttt tgtggtccca aaatcttgtg ctgcggaggg      773

agggaagggg tggcaggtcc ctgttttgtt ctgtctcaag gtgatactct gtaatgcctt      833

ggacagcgtg gctggcattc caaggactta acggctgtca catggaatca gcggcctgga      893

ggggaactag catatttccc actgttaccc catcttgggg ctatatcctg ggcttgaaca      953

taaaggcatt atcagacccg gggagaaaca gtcagtgggg gagatttagg gacaaaacaa     1013

acctcaggtt ggcccaaggg acccctgctg taacaattcc aggatgggga gtcagataga     1073

ctacaggata taggagaaaa ggcaggggca gagcggggcc gtgggggcct ggcctga        1130


<210>  246
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Val Leu Leu Gly Cys Met Trp Val Thr Lys Asp Gly Ala Gly Glu 
1               5                   10                  15      


Arg Ser Thr Arg Gln His Gln Pro Cys Pro His Ser Thr Thr Pro Pro 
            20                  25                  30          


Thr Pro Val Pro Ala Val Arg Ala Arg Glu Arg Ala Leu Arg Ala Gly 
        35                  40                  45              


Pro Lys Gly Ser Thr Trp Leu Gly Arg Ala Gly Lys Arg Arg Pro Thr 
    50                  55                  60                  


Pro Arg Leu Arg Gly Gly Gly His His Gly Phe Ala Ser Arg Val Pro 
65                  70                  75                  80  


Ser His Ala Ser Cys Ser Gln Leu Cys Ala Ala Cys Ser Gly Leu Ser 
                85                  90                  95      


Trp Arg Tyr Glu Val Pro Val Gln Val Ser Asp Phe Gly Leu Val Arg 
            100                 105                 110         


Trp Trp Arg Arg Ser Arg Ala Gly Leu Val Arg Met Ile Thr Asp Val 
        115                 120                 125             


Gln Leu Ala Ile Phe Ala Asn Met Leu Gly Val Ser Leu Phe Leu Leu 
    130                 135                 140                 


Val Val Leu Tyr His Tyr Val Ala Val Asn Asn Pro Lys Lys Gln Glu 
145                 150                 155                 160 


<210>  247
<211>  2309
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (145)..(735)

<400>  247
aatcgctccg gagcttctgg agggggcaga tgcaggtgcc ggctgctgca gtgcagtagc       60

tgctggaggc tggggaggcc cggacccggt gcaggaagac gccgaccacg cgggctcctg      120

atcgcgggcg cccacagcgc ggac atg gcg ggc tgg tgg ccg gcg ttg tcg         171
                           Met Ala Gly Trp Trp Pro Ala Leu Ser            
                           1               5                              

cgc gcg gcc cgg cgc cac ccg tgg ccc acc aac gtg ctg ctt tac ggc        219
Arg Ala Ala Arg Arg His Pro Trp Pro Thr Asn Val Leu Leu Tyr Gly           
10                  15                  20                  25            

tcg ctc gtc tcg gcc ggg gac gcg ctg caa cag cgg ctg cag ggc cgc        267
Ser Leu Val Ser Ala Gly Asp Ala Leu Gln Gln Arg Leu Gln Gly Arg           
                30                  35                  40                

gag gcc aac tgg cgc cag acg cgg cgc gtg gcc acg ttg gtg gtg acc        315
Glu Ala Asn Trp Arg Gln Thr Arg Arg Val Ala Thr Leu Val Val Thr           
            45                  50                  55                    

ttc cac gcc aac ttc aac tac gtg tgg ctg cgc ctg ctg gag cgc gcg        363
Phe His Ala Asn Phe Asn Tyr Val Trp Leu Arg Leu Leu Glu Arg Ala           
        60                  65                  70                        

ctc ccg ggc cga gcg ccg cac gcc ctg ctg gcc aag ttg ctg tgc gac        411
Leu Pro Gly Arg Ala Pro His Ala Leu Leu Ala Lys Leu Leu Cys Asp           
    75                  80                  85                            

cag gtg gtc ggt gcg ccc atc gcg gtc tcg gcc ttc tat gtc ggt atg        459
Gln Val Val Gly Ala Pro Ile Ala Val Ser Ala Phe Tyr Val Gly Met           
90                  95                  100                 105           

agc att ctc caa gga aag gat gac ata ttt ttg gac ctg aaa cag aaa        507
Ser Ile Leu Gln Gly Lys Asp Asp Ile Phe Leu Asp Leu Lys Gln Lys           
                110                 115                 120               

ttc tgg aat acc tat ctg agt gga ctg atg tac tgg ccc ttt gta cag        555
Phe Trp Asn Thr Tyr Leu Ser Gly Leu Met Tyr Trp Pro Phe Val Gln           
            125                 130                 135                   

ctg acc aac ttc agc ctt gtt cct gtt caa tgg aga aca gct tac gct        603
Leu Thr Asn Phe Ser Leu Val Pro Val Gln Trp Arg Thr Ala Tyr Ala           
        140                 145                 150                       

gga gtc tgt ggt ttt ctc tgg gcc acc ttc atc tgt ttt tcc cag cag        651
Gly Val Cys Gly Phe Leu Trp Ala Thr Phe Ile Cys Phe Ser Gln Gln           
    155                 160                 165                           

agt ggt gac ggc aca ttc aag tca gct ttc acc att tta tat aca aag        699
Ser Gly Asp Gly Thr Phe Lys Ser Ala Phe Thr Ile Leu Tyr Thr Lys           
170                 175                 180                 185           

ggg acc agt gcc aca gaa ggg tac ccg aag aaa tga gaagtcaagg             745
Gly Thr Ser Ala Thr Glu Gly Tyr Pro Lys Lys                               
                190                 195                                   

actctcttaa agggaccaca ttttttacct aaaatgcaca gaattgcctg cagacaaaat      805

atttgatgtg ccaattatgc acttcatttt gaggaattac tactatttat agacccactt      865

tttaaaaaat tatcaatgat tatttttgaa ttgtattcag acttttttcc tgttctagtc      925

tgaaatatta cttctctaat attttggtta atatgaataa tagtggcaaa atggcatttt      985

agaattatta atatttctaa tattttaaca caagtttcag gaaacttggt tttgattgtt     1045

cacatttcta ttctaaaatc tcaggttatc tcctgaacac ttttgggcag atgaagtttt     1105

ataccaaaaa atagttctta gagtgaattt taatttacat agaactcaat cgaaatgaag     1165

atttaataac cagatttctt tctccaaaac atacacaatt tgttatttta gtaaatacct     1225

tttttttttt tttttttttt gtggtggagt cttgctgtct ccccggctgg agcgcagtgg     1285

cacgatcgcg gctcactgca gcctccatcc tctgggttca agcaattctc ctgcctcagg     1345

ctcctgagta gctgggatta caggcacgtg acaccaggcc cagctgattt ttgtattttt     1405

gttcatttgc ttttgttttt gacacagagt ctcgctctgt cgcccaggct ggaatgcagt     1465

tgtgagatct cggctcactg caagctccgc ctcccgggtt cacgccattc tgcgtcagcc     1525

tcccaagtag ctgggactac aggcacctgc cacgatgcct agctaatttt ttgtattttt     1585

agtagagatg aagtttcacc gtgttggcca ggatggtctt gatctcctga ccgcataatc     1645

cacccacctc ggcctcccaa agtgctggga ttacaggcgt gagccaccac aaccgacttt     1705

tttttttttt tttttttgag acagagactc gctctgtcac ccaggctgga gtgcagtggc     1765

atgatttcgg ctcactgcaa cctctgtctc ctgggttcaa acgatcctac tgcctcatcc     1825

ttcggagtag ctgggattac aggcaggtgc caccatgcct ggctcatttt tgtattttta     1885

gtagagaggg cgttttgcca tgttggctag gctggtctct gtccgtcctc tgagctcaag     1945

ctaagccatc atatcccagt gacctgcaca tatacatcca gatggcctga agttactgaa     2005

gatccacaga agtgaaaata gccttaactg atgacattgc accattgtga tatgttactg     2065

ccccacccta actgatcaat gtactttgta atcctcccac ccttaagaag gttcttttta     2125

attctcccca cccttgagaa tgtactttgt gagatccacc cctgcccgca aaacattgct     2185

ccaaactcca ccacctatcc ccaaacctgt aagaactaat gataatccac caccctttgc     2245

tgactccttt tttggactca gcccgcctgc actcaggtga aataaacagc catgttgctc     2305

atac                                                                  2309


<210>  248
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Ala Gly Trp Trp Pro Ala Leu Ser Arg Ala Ala Arg Arg His Pro 
1               5                   10                  15      


Trp Pro Thr Asn Val Leu Leu Tyr Gly Ser Leu Val Ser Ala Gly Asp 
            20                  25                  30          


Ala Leu Gln Gln Arg Leu Gln Gly Arg Glu Ala Asn Trp Arg Gln Thr 
        35                  40                  45              


Arg Arg Val Ala Thr Leu Val Val Thr Phe His Ala Asn Phe Asn Tyr 
    50                  55                  60                  


Val Trp Leu Arg Leu Leu Glu Arg Ala Leu Pro Gly Arg Ala Pro His 
65                  70                  75                  80  


Ala Leu Leu Ala Lys Leu Leu Cys Asp Gln Val Val Gly Ala Pro Ile 
                85                  90                  95      


Ala Val Ser Ala Phe Tyr Val Gly Met Ser Ile Leu Gln Gly Lys Asp 
            100                 105                 110         


Asp Ile Phe Leu Asp Leu Lys Gln Lys Phe Trp Asn Thr Tyr Leu Ser 
        115                 120                 125             


Gly Leu Met Tyr Trp Pro Phe Val Gln Leu Thr Asn Phe Ser Leu Val 
    130                 135                 140                 


Pro Val Gln Trp Arg Thr Ala Tyr Ala Gly Val Cys Gly Phe Leu Trp 
145                 150                 155                 160 


Ala Thr Phe Ile Cys Phe Ser Gln Gln Ser Gly Asp Gly Thr Phe Lys 
                165                 170                 175     


Ser Ala Phe Thr Ile Leu Tyr Thr Lys Gly Thr Ser Ala Thr Glu Gly 
            180                 185                 190         


Tyr Pro Lys Lys 
        195     


<210>  249
<211>  1574
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (60)..(611)

<400>  249
acttccggcg cactgatccc gcctggggcc ggctgagtgg cacttaagcg ggccatgcc        59

atg caa cct tgg gcg ctg cca acc gtg ggc gag ctc tgg gtg tgc ggg        107
Met Gln Pro Trp Ala Leu Pro Thr Val Gly Glu Leu Trp Val Cys Gly           
1               5                   10                  15                

cgg cct ggc gcg gcg ctc cga tgg agt cta gtt ctg tcg ccc agg ctg        155
Arg Pro Gly Ala Ala Leu Arg Trp Ser Leu Val Leu Ser Pro Arg Leu           
            20                  25                  30                    

gag ccc agt ggt gtg atc tca gct cac tgc aat ctc cac ctc ctg gct        203
Glu Pro Ser Gly Val Ile Ser Ala His Cys Asn Leu His Leu Leu Ala           
        35                  40                  45                        

tca agc gat tct tct gct tca gcc tcc cga ctg tgt cag cgt gtt atg        251
Ser Ser Asp Ser Ser Ala Ser Ala Ser Arg Leu Cys Gln Arg Val Met           
    50                  55                  60                            

atg ccg tcc cgt acc aac ctg gct act gga atc ccc agt agt aaa gtg        299
Met Pro Ser Arg Thr Asn Leu Ala Thr Gly Ile Pro Ser Ser Lys Val           
65                  70                  75                  80            

aaa tat tca agg ctc tcc agc aca gac gat ggc tac att gac ctt cag        347
Lys Tyr Ser Arg Leu Ser Ser Thr Asp Asp Gly Tyr Ile Asp Leu Gln           
                85                  90                  95                

ttt aag aaa acc cct cct aag atc cct tat aag gcc atc gca ctt gcc        395
Phe Lys Lys Thr Pro Pro Lys Ile Pro Tyr Lys Ala Ile Ala Leu Ala           
            100                 105                 110                   

act gtg ctg ttt ttg att ggc gcc ttt ctc att att ata ggc tcc ctc        443
Thr Val Leu Phe Leu Ile Gly Ala Phe Leu Ile Ile Ile Gly Ser Leu           
        115                 120                 125                       

ctg ctg tca ggc tac atc agc aaa ggg ggg gca gac cgg gcc gtt cca        491
Leu Leu Ser Gly Tyr Ile Ser Lys Gly Gly Ala Asp Arg Ala Val Pro           
    130                 135                 140                           

gtg ctg atc att ggc att ctg gtg ttc cta ccc gga ttt tac cac ctg        539
Val Leu Ile Ile Gly Ile Leu Val Phe Leu Pro Gly Phe Tyr His Leu           
145                 150                 155                 160           

cgc atc gct tac tat gca tcc aaa ggc tac cgt ggt tac tcc tat gat        587
Arg Ile Ala Tyr Tyr Ala Ser Lys Gly Tyr Arg Gly Tyr Ser Tyr Asp           
                165                 170                 175               

gac att cca gac ttt gat gac tag cacccacccc atagctgagg aggagtcaca       641
Asp Ile Pro Asp Phe Asp Asp                                               
            180                                                           

gtggaactgt cccagcttta agatatctag cagaaactat agctgaggac taaggaattc      701

tgcagcttgc agatgtttaa gaaaataatg gccagatttt ttgggtcctt cccaaagatg      761

ttaagtgaac ctacagttag ctaattagga caagctctat ttttcatccc tgggccctga      821

caagtttttc cacaggaata tgtatcatgg aagaatagag gttattctgt aatggaaaag      881

tgttgcctgc caccaccctc tgtagagctg agcatttctt ttaaatagtc ttcattgcca      941

atttgttctt gtagcaaatg gaacaatgtg gtatggctaa tttcttatta ttaagtaatt     1001

tattttaaaa atatctgagt atattatcct gtacacttat ccctaccttc atgttccagt     1061

ggaagacctt agtaaaatca aagatcagtg agttcatctg taatattttt tttacttgct     1121

ttcttactga cagcaaccag gaattttttt atcctgcaga gcaagttttc aaaatgtaaa     1181

tacttcctct gtttaacagt ccttggacca ttctgatcca gttcaccagt aggttggaca     1241

gcatataatt tgcatcattt tgtcccttgt aaatcaagat gttctgcaga ttattccttt     1301

aacggccgga cttttggctg tttcctaatg aaacatgtag tggttattat ttagagttta     1361

tagccgtatt gctagcacct tgtagtatgt catcattctg ctcatgattc caaggatcag     1421

cctggatgcc tagaggacta gatcacctta gtttgattct attttttagc ttgcaaaaag     1481

tgacttatat tccaaagaaa ttaaaatgtt gaaatccaaa tcctagaaat aaaatgagtt     1541

aacttcaaac atttcagaaa acaaaaaaaa aaa                                  1574


<210>  250
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Gln Pro Trp Ala Leu Pro Thr Val Gly Glu Leu Trp Val Cys Gly 
1               5                   10                  15      


Arg Pro Gly Ala Ala Leu Arg Trp Ser Leu Val Leu Ser Pro Arg Leu 
            20                  25                  30          


Glu Pro Ser Gly Val Ile Ser Ala His Cys Asn Leu His Leu Leu Ala 
        35                  40                  45              


Ser Ser Asp Ser Ser Ala Ser Ala Ser Arg Leu Cys Gln Arg Val Met 
    50                  55                  60                  


Met Pro Ser Arg Thr Asn Leu Ala Thr Gly Ile Pro Ser Ser Lys Val 
65                  70                  75                  80  


Lys Tyr Ser Arg Leu Ser Ser Thr Asp Asp Gly Tyr Ile Asp Leu Gln 
                85                  90                  95      


Phe Lys Lys Thr Pro Pro Lys Ile Pro Tyr Lys Ala Ile Ala Leu Ala 
            100                 105                 110         


Thr Val Leu Phe Leu Ile Gly Ala Phe Leu Ile Ile Ile Gly Ser Leu 
        115                 120                 125             


Leu Leu Ser Gly Tyr Ile Ser Lys Gly Gly Ala Asp Arg Ala Val Pro 
    130                 135                 140                 


Val Leu Ile Ile Gly Ile Leu Val Phe Leu Pro Gly Phe Tyr His Leu 
145                 150                 155                 160 


Arg Ile Ala Tyr Tyr Ala Ser Lys Gly Tyr Arg Gly Tyr Ser Tyr Asp 
                165                 170                 175     


Asp Ile Pro Asp Phe Asp Asp 
            180             


<210>  251
<211>  4846
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (144)..(2513)

<400>  251
atcttggatt ccgcggtagc ggaggcggcg gtcaggcgcc gcttctgggg agtggccttt       60

cttttcccct ccctcccggt tcggtggcgg cggctcctcc cactgggggg gggggtggcg      120

cggcggcggt ggcatctgcg gcc atg gcg gcg act act gcc aac ccc gaa atg      173
                          Met Ala Ala Thr Thr Ala Asn Pro Glu Met         
                          1               5                   10          

aca tca gat gta cca tca ctg ggt cca gcc att gcc tct gga aac tct        221
Thr Ser Asp Val Pro Ser Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser           
                15                  20                  25                

gga cct gga att caa ggt gga gga gcc att gtc cag agg gct att aag        269
Gly Pro Gly Ile Gln Gly Gly Gly Ala Ile Val Gln Arg Ala Ile Lys           
            30                  35                  40                    

cgg cga cca ggg ctg gat ttt gat gat gat gga gaa ggg aac agt aaa        317
Arg Arg Pro Gly Leu Asp Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys           
        45                  50                  55                        

ttt ttg agg tgt gat gat gat cag atg tct aac gat aag gag cgg ttt        365
Phe Leu Arg Cys Asp Asp Asp Gln Met Ser Asn Asp Lys Glu Arg Phe           
    60                  65                  70                            

gcc agg tcg gat gat gag cag agc tct gcg gat aaa gag aga ctt gcc        413
Ala Arg Ser Asp Asp Glu Gln Ser Ser Ala Asp Lys Glu Arg Leu Ala           
75                  80                  85                  90            

agg gaa aat cac agt gaa att gaa cgg cgg cga cgg aac aag atg aca        461
Arg Glu Asn His Ser Glu Ile Glu Arg Arg Arg Arg Asn Lys Met Thr           
                95                  100                 105               

gcc tac atc aca gaa ctg tca gat atg gta ccc acc tgt agt gcc ctg        509
Ala Tyr Ile Thr Glu Leu Ser Asp Met Val Pro Thr Cys Ser Ala Leu           
            110                 115                 120                   

gct cga aaa cca gac aag cta acc atc tta cgc atg gca gtt tct cac        557
Ala Arg Lys Pro Asp Lys Leu Thr Ile Leu Arg Met Ala Val Ser His           
        125                 130                 135                       

atg aag tcc ttg cgg gga act ggc aac aca tcc act gat ggc tcc tat        605
Met Lys Ser Leu Arg Gly Thr Gly Asn Thr Ser Thr Asp Gly Ser Tyr           
    140                 145                 150                           

aag ccg tct ttc ctc act gat cag gaa ctg aaa cat ttg atc ttg gag        653
Lys Pro Ser Phe Leu Thr Asp Gln Glu Leu Lys His Leu Ile Leu Glu           
155                 160                 165                 170           

gca gca gat ggc ttt ctg ttt att gtc tca tgt gag aca ggc agg gtg        701
Ala Ala Asp Gly Phe Leu Phe Ile Val Ser Cys Glu Thr Gly Arg Val           
                175                 180                 185               

gtg tat gtg tct gac tcc gtg act cct gtt ttg aac cag cca cag tct        749
Val Tyr Val Ser Asp Ser Val Thr Pro Val Leu Asn Gln Pro Gln Ser           
            190                 195                 200                   

gaa tgg ttt ggc agc aca ctc tat gat cag gtg cac cca gat gat gtg        797
Glu Trp Phe Gly Ser Thr Leu Tyr Asp Gln Val His Pro Asp Asp Val           
        205                 210                 215                       

gat aaa ctt cgt gag cag ctt tcc act tca gaa aat gcc ctg aca ggg        845
Asp Lys Leu Arg Glu Gln Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly           
    220                 225                 230                           

cgt atc ctg gat cta aag act gga aca gtg aaa aag gaa ggt cag cag        893
Arg Ile Leu Asp Leu Lys Thr Gly Thr Val Lys Lys Glu Gly Gln Gln           
235                 240                 245                 250           

tct tcc atg aga atg tgt atg ggc tca agg aga tcg ttt att tgc cga        941
Ser Ser Met Arg Met Cys Met Gly Ser Arg Arg Ser Phe Ile Cys Arg           
                255                 260                 265               

atg agg tgt ggc agt agc tct gtg gac cca gtt tct gtg aat agg ctg        989
Met Arg Cys Gly Ser Ser Ser Val Asp Pro Val Ser Val Asn Arg Leu           
            270                 275                 280                   

agc ttt gtg agg aac aga tgc agg aat gga ctt ggc tct gta aag gat       1037
Ser Phe Val Arg Asn Arg Cys Arg Asn Gly Leu Gly Ser Val Lys Asp           
        285                 290                 295                       

ggg gaa cct cac ttc gtg gtg gtc cac tgc aca ggc tac atc aag gcc       1085
Gly Glu Pro His Phe Val Val Val His Cys Thr Gly Tyr Ile Lys Ala           
    300                 305                 310                           

tgg ccc cca gca ggt gtt tcc ctc cca gat gat gac cca gag gct ggc       1133
Trp Pro Pro Ala Gly Val Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly           
315                 320                 325                 330           

cag gga agc aag ttt tgc cta gtg gcc att ggc aga ttg cag gta act       1181
Gln Gly Ser Lys Phe Cys Leu Val Ala Ile Gly Arg Leu Gln Val Thr           
                335                 340                 345               

agt tct ccc aac tgt aca gac atg agt aat gtt tgt caa cca aca gag       1229
Ser Ser Pro Asn Cys Thr Asp Met Ser Asn Val Cys Gln Pro Thr Glu           
            350                 355                 360                   

ttc atc tcc cga cac aac att gag ggt atc ttc act ttt gtg gat cac       1277
Phe Ile Ser Arg His Asn Ile Glu Gly Ile Phe Thr Phe Val Asp His           
        365                 370                 375                       

cgc tgt gtg gct act gtt ggc tac cag cca cag gaa ctc tta gga aag       1325
Arg Cys Val Ala Thr Val Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys           
    380                 385                 390                           

aat att gta gaa ttc tgt cat cct gaa gac cag cag ctt cta aga gac       1373
Asn Ile Val Glu Phe Cys His Pro Glu Asp Gln Gln Leu Leu Arg Asp           
395                 400                 405                 410           

agc ttc caa cag gta gtg aaa tta aaa ggc caa gtg ctg tct gtc atg       1421
Ser Phe Gln Gln Val Val Lys Leu Lys Gly Gln Val Leu Ser Val Met           
                415                 420                 425               

ttc cgg ttc cgg tct aag aac caa gaa tgg ctc tgg atg aga acc agc       1469
Phe Arg Phe Arg Ser Lys Asn Gln Glu Trp Leu Trp Met Arg Thr Ser           
            430                 435                 440                   

tcc ttt act ttc cag aac cct tac tca gat gaa att gag tac atc atc       1517
Ser Phe Thr Phe Gln Asn Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile           
        445                 450                 455                       

tgt acc aac acc aat gtg aag aac tct agc caa gaa cca cgg cct aca       1565
Cys Thr Asn Thr Asn Val Lys Asn Ser Ser Gln Glu Pro Arg Pro Thr           
    460                 465                 470                           

ctc tcc aac aca atc cag agg cca caa cta ggt ccc aca gct aat tta       1613
Leu Ser Asn Thr Ile Gln Arg Pro Gln Leu Gly Pro Thr Ala Asn Leu           
475                 480                 485                 490           

ccc ctg gag atg ggc tca gga cag ctg gca ccc agg cag cag caa cag       1661
Pro Leu Glu Met Gly Ser Gly Gln Leu Ala Pro Arg Gln Gln Gln Gln           
                495                 500                 505               

caa aca gaa ttg gac atg gta cca gga aga gat gga ctg gcc agc tac       1709
Gln Thr Glu Leu Asp Met Val Pro Gly Arg Asp Gly Leu Ala Ser Tyr           
            510                 515                 520                   

aat cat tcc cag gtg gtt cag cct gtg aca acc aca gga cca gaa cac       1757
Asn His Ser Gln Val Val Gln Pro Val Thr Thr Thr Gly Pro Glu His           
        525                 530                 535                       

agc aag ccc ctt gag aag tca gat ggt tta ttt gcc cag gat aga gat       1805
Ser Lys Pro Leu Glu Lys Ser Asp Gly Leu Phe Ala Gln Asp Arg Asp           
    540                 545                 550                           

cca aga ttt tca gaa atc tat cac aac atc aat gcg gat cag agt aaa       1853
Pro Arg Phe Ser Glu Ile Tyr His Asn Ile Asn Ala Asp Gln Ser Lys           
555                 560                 565                 570           

ggc atc tcc tcc agc act gtc cct gcc acc caa cag cta ttc tcc cag       1901
Gly Ile Ser Ser Ser Thr Val Pro Ala Thr Gln Gln Leu Phe Ser Gln           
                575                 580                 585               

ggc aac aca ttc cct cct acc ccc cgg ccg gca gag aat ttc agg aat       1949
Gly Asn Thr Phe Pro Pro Thr Pro Arg Pro Ala Glu Asn Phe Arg Asn           
            590                 595                 600                   

agt ggc cta gcc cct cct gta acc att gtc cag cca tca gct tct gca       1997
Ser Gly Leu Ala Pro Pro Val Thr Ile Val Gln Pro Ser Ala Ser Ala           
        605                 610                 615                       

gga cag atg ttg gcc cag att tcc cgc cac tcc aac ccc acc caa gga       2045
Gly Gln Met Leu Ala Gln Ile Ser Arg His Ser Asn Pro Thr Gln Gly           
    620                 625                 630                           

gca acc cca act tgg acc cct act acc cgc tca ggc ttt tct gcc cag       2093
Ala Thr Pro Thr Trp Thr Pro Thr Thr Arg Ser Gly Phe Ser Ala Gln           
635                 640                 645                 650           

cag gtg gct acc cag gct act gct aag act cgt act tcc cag ttt ggt       2141
Gln Val Ala Thr Gln Ala Thr Ala Lys Thr Arg Thr Ser Gln Phe Gly           
                655                 660                 665               

gtg ggc agc ttt cag act cca tcc tcc ttc agc tcc atg tcc ctc cct       2189
Val Gly Ser Phe Gln Thr Pro Ser Ser Phe Ser Ser Met Ser Leu Pro           
            670                 675                 680                   

ggt gcc cca act gca tcg cct ggt gct gct gcc tac cct agt ctc acc       2237
Gly Ala Pro Thr Ala Ser Pro Gly Ala Ala Ala Tyr Pro Ser Leu Thr           
        685                 690                 695                       

aat cgt gga tct aac ttt gct cct gag act gga cag act gca gga caa       2285
Asn Arg Gly Ser Asn Phe Ala Pro Glu Thr Gly Gln Thr Ala Gly Gln           
    700                 705                 710                           

ttc cag aca cgg aca gca gag ggt gtg ggt gtc tgg cca cag tgg cag       2333
Phe Gln Thr Arg Thr Ala Glu Gly Val Gly Val Trp Pro Gln Trp Gln           
715                 720                 725                 730           

ggc cag cag cct cat cat cgt tca agt tct agt gag caa cat gtt caa       2381
Gly Gln Gln Pro His His Arg Ser Ser Ser Ser Glu Gln His Val Gln           
                735                 740                 745               

caa ccg cca gca cag caa cct ggc cag cct gag gtc ttc cag gag atg       2429
Gln Pro Pro Ala Gln Gln Pro Gly Gln Pro Glu Val Phe Gln Glu Met           
            750                 755                 760                   

ctg tcc atg ctg gga gat cag agc aac agc tac aac aat gaa gaa ttc       2477
Leu Ser Met Leu Gly Asp Gln Ser Asn Ser Tyr Asn Asn Glu Glu Phe           
        765                 770                 775                       

cct gat cta act atg ttt ccc ccc ttt tca gaa tag aactattggg            2523
Pro Asp Leu Thr Met Phe Pro Pro Phe Ser Glu                               
    780                 785                                               

gtgaggataa ggggtggggg agaaaaaatc actgtttgtt tttaaaaagc aaatctttct     2583

gtaaacagaa taaaagttcc tctcccttcc cttccctcac ccctgacatg tacccccttt     2643

cccttctggc tgttcccctg ctctgttgcc tctctaaggt aacatttata gaagaaatgg     2703

aatgaatctc caaggctttt aggactgtct gaaaatttga ggctgggtga agttaaaaca     2763

cctttcctta tgtctcctga cctgaaattg tatagtgttg atttgtgctg agatcaagag     2823

gcaggttaga agaacctgac atccactgtt tgccttggat agtatggctt gtttttggaa     2883

agaaattctg aagagagtgg aggagaggag aaatgtcctc atatttgagg accatgaaac     2943

attgtaggta tatatggggc tttagcaagt ttgagcatag gctctttttg ctgcctgtga     3003

gcagtccctc tggaaagaaa catgtgagta agtgagagag agtgtgtgtg tatgtgtgtg     3063

tgtgtgtgtg tgcgcacaca tgcttctgta tttcactctt tctccctatt agggagttat     3123

gcaaaatttg tccccgattt tacctttgtc tttctgtgta cttttcaaag agtcctaagg     3183

agttaaatct tccaggtatt ttccacttag tattgcagcc aaagaatatt taaataaacg     3243

tctttgctgc gcttgcatcc atgcccagcc aatatacaac tgtaaagcaa atatagaaag     3303

tcggctgttg atacgattgt ctgttatcga acacattcag tgataaagct gggttactgc     3363

tgcttttggt gctctcacct tatctggaag atctgcaaac attacctaaa taggctggca     3423

agataaacac tttctggaac ccgagacttg gccataaaga taatgctgca tttttctgtc     3483

agaatcacat atgatgtgtg ttctgtagag gttatttctg catggaaact caacttcttg     3543

gattagccgt cccagtgaaa atcctcattg ttggagtgta aaccaaatac gaagccctct     3603

tgcaaagtag cctctttcat cccatactca aaatacccag tttagcaagc aactgagatt     3663

taagtctctc tggccctaag aggtttttcc tctttgctcc ctccaatctt gagattgggt     3723

tttgctttag agtgcaagta tcataattcc gtatgataga tggggcctgg acacccatct     3783

caacagggtc acttggtaat taacaatagc catataaatg cggatacagg ttactaccct     3843

caccctttac cttcctcagg taacagtcgt agataccagc tttttttttt ttttttttaa     3903

attggctttg gccagtagct aaagtgcaag actgaattaa tgagaagata tattaaatgt     3963

agtcataggg gactgaggag caagggtggc cttgaagagg ccaaaggaat gtccatttgc     4023

tgagtttccc ttccttatgt ctccagtctg gtgccaggta gtggagtaaa aaaggagaca     4083

gtttattttt ttattctatg tgcacactta cagtatacat atatatttat atcacaattt     4143

acgaaaccaa aaagttgagt ttccaatgga acccttgttt tttaataatc gactttttaa     4203

atgtgatcag gactataata ttgtacagtt attatagggc ttttggggaa ggggaggata     4263

gcgagaagat gctctggggg ttttgttttt gcttttcctt cagggtttta tttttgactg     4323

ttttgttttc ttgttggcca tttctgtatt gctggcatct gtgctaagct ttacagtggc     4383

aaaaataatg acatgtagca aagattttca aacaaaatat tttttccttt tgtaaaattt     4443

cttgtgttgt gtgatcttga ttgcggcttt atcattcctt tccagttcat aaacaacagg     4503

cacccacaac cagaggaatc tatagtttaa gctccagaca tacaaacata aggcacattg     4563

tgtctttaat ttcaggaatc agaaatcata gggttctgat cacattgcac gcctcccccc     4623

tcacttgtcc tcctgatcct gacacattct gagtaacatc agcaggaatg ctctgaccat     4683

gaggtggggg ttttggggtg ggcgttgcct gggttcttgg gagagagggg aagagtcggg     4743

acttgaaaac cactagggca catctggatg ccttccccca gtatgtcctt ttctggatta     4803

aaatgagtga aatttaaact gaaaaaaaaa aaaaaaaaaa aaa                       4846


<210>  252
<211>  789
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Ala Ala Thr Thr Ala Asn Pro Glu Met Thr Ser Asp Val Pro Ser 
1               5                   10                  15      


Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly 
            20                  25                  30          


Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Leu Asp 
        35                  40                  45              


Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp 
    50                  55                  60                  


Asp Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Ser Asp Asp Glu 
65                  70                  75                  80  


Gln Ser Ser Ala Asp Lys Glu Arg Leu Ala Arg Glu Asn His Ser Glu 
                85                  90                  95      


Ile Glu Arg Arg Arg Arg Asn Lys Met Thr Ala Tyr Ile Thr Glu Leu 
            100                 105                 110         


Ser Asp Met Val Pro Thr Cys Ser Ala Leu Ala Arg Lys Pro Asp Lys 
        115                 120                 125             


Leu Thr Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg Gly 
    130                 135                 140                 


Thr Gly Asn Thr Ser Thr Asp Gly Ser Tyr Lys Pro Ser Phe Leu Thr 
145                 150                 155                 160 


Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu 
                165                 170                 175     


Phe Ile Val Ser Cys Glu Thr Gly Arg Val Val Tyr Val Ser Asp Ser 
            180                 185                 190         


Val Thr Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser Thr 
        195                 200                 205             


Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln 
    210                 215                 220                 


Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly Arg Ile Leu Asp Leu Lys 
225                 230                 235                 240 


Thr Gly Thr Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met Cys 
                245                 250                 255     


Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser Ser 
            260                 265                 270         


Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn Arg 
        275                 280                 285             


Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe Val 
    290                 295                 300                 


Val Val His Cys Thr Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly Val 
305                 310                 315                 320 


Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys Phe Cys 
                325                 330                 335     


Leu Val Ala Ile Gly Arg Leu Gln Val Thr Ser Ser Pro Asn Cys Thr 
            340                 345                 350         


Asp Met Ser Asn Val Cys Gln Pro Thr Glu Phe Ile Ser Arg His Asn 
        355                 360                 365             


Ile Glu Gly Ile Phe Thr Phe Val Asp His Arg Cys Val Ala Thr Val 
    370                 375                 380                 


Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu Phe Cys 
385                 390                 395                 400 


His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln Val Val 
                405                 410                 415     


Lys Leu Lys Gly Gln Val Leu Ser Val Met Phe Arg Phe Arg Ser Lys 
            420                 425                 430         


Asn Gln Glu Trp Leu Trp Met Arg Thr Ser Ser Phe Thr Phe Gln Asn 
        435                 440                 445             


Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile Cys Thr Asn Thr Asn Val 
    450                 455                 460                 


Lys Asn Ser Ser Gln Glu Pro Arg Pro Thr Leu Ser Asn Thr Ile Gln 
465                 470                 475                 480 


Arg Pro Gln Leu Gly Pro Thr Ala Asn Leu Pro Leu Glu Met Gly Ser 
                485                 490                 495     


Gly Gln Leu Ala Pro Arg Gln Gln Gln Gln Gln Thr Glu Leu Asp Met 
            500                 505                 510         


Val Pro Gly Arg Asp Gly Leu Ala Ser Tyr Asn His Ser Gln Val Val 
        515                 520                 525             


Gln Pro Val Thr Thr Thr Gly Pro Glu His Ser Lys Pro Leu Glu Lys 
    530                 535                 540                 


Ser Asp Gly Leu Phe Ala Gln Asp Arg Asp Pro Arg Phe Ser Glu Ile 
545                 550                 555                 560 


Tyr His Asn Ile Asn Ala Asp Gln Ser Lys Gly Ile Ser Ser Ser Thr 
                565                 570                 575     


Val Pro Ala Thr Gln Gln Leu Phe Ser Gln Gly Asn Thr Phe Pro Pro 
            580                 585                 590         


Thr Pro Arg Pro Ala Glu Asn Phe Arg Asn Ser Gly Leu Ala Pro Pro 
        595                 600                 605             


Val Thr Ile Val Gln Pro Ser Ala Ser Ala Gly Gln Met Leu Ala Gln 
    610                 615                 620                 


Ile Ser Arg His Ser Asn Pro Thr Gln Gly Ala Thr Pro Thr Trp Thr 
625                 630                 635                 640 


Pro Thr Thr Arg Ser Gly Phe Ser Ala Gln Gln Val Ala Thr Gln Ala 
                645                 650                 655     


Thr Ala Lys Thr Arg Thr Ser Gln Phe Gly Val Gly Ser Phe Gln Thr 
            660                 665                 670         


Pro Ser Ser Phe Ser Ser Met Ser Leu Pro Gly Ala Pro Thr Ala Ser 
        675                 680                 685             


Pro Gly Ala Ala Ala Tyr Pro Ser Leu Thr Asn Arg Gly Ser Asn Phe 
    690                 695                 700                 


Ala Pro Glu Thr Gly Gln Thr Ala Gly Gln Phe Gln Thr Arg Thr Ala 
705                 710                 715                 720 


Glu Gly Val Gly Val Trp Pro Gln Trp Gln Gly Gln Gln Pro His His 
                725                 730                 735     


Arg Ser Ser Ser Ser Glu Gln His Val Gln Gln Pro Pro Ala Gln Gln 
            740                 745                 750         


Pro Gly Gln Pro Glu Val Phe Gln Glu Met Leu Ser Met Leu Gly Asp 
        755                 760                 765             


Gln Ser Asn Ser Tyr Asn Asn Glu Glu Phe Pro Asp Leu Thr Met Phe 
    770                 775                 780                 


Pro Pro Phe Ser Glu 
785                 


<210>  253
<211>  1521
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (353)..(1168)

<400>  253
cgggcttccc ctccccggtc cgcgggtgcc cggcgcgggc ccaggaggcg gaggcggctc       60

ctggggagag ggatccggga gtccctgagg cggccccggc tccgcactag gaggcggggt      120

ccgcagtatc gccagcggcc ggcgcggctt cccggagccc cggagcccga ggcgcgaggt      180

ttaggctgag ccctccccgg cgcctgcccc cgcccggcgc ccgcctccgc ccccgcccgc      240

ggcctggagc gcgcctccct cgcctcccag ggtctggcga gccggcgccg gccgagctgc      300

gggagccgcg gagagcacca gctgacgccg cgggagctgc tccggccgca cc atg cgg      358
                                                          Met Arg         
                                                          1               

gag ctg gcc att gag atc ggg gtg cga gcc ctg ctc ttc gga gtc ttc        406
Glu Leu Ala Ile Glu Ile Gly Val Arg Ala Leu Leu Phe Gly Val Phe           
        5                   10                  15                        

gtt ttt aca gag ttt ttg gat ccg ttc cag aga gtc atc cag cca gaa        454
Val Phe Thr Glu Phe Leu Asp Pro Phe Gln Arg Val Ile Gln Pro Glu           
    20                  25                  30                            

gag atc tgg ctc tat aaa aat cct ttg gtg caa tca gat aac ata cct        502
Glu Ile Trp Leu Tyr Lys Asn Pro Leu Val Gln Ser Asp Asn Ile Pro           
35                  40                  45                  50            

acc cgc ctc atg ttt gca att tct ttc ctc aca ccc ctg gct gtt att        550
Thr Arg Leu Met Phe Ala Ile Ser Phe Leu Thr Pro Leu Ala Val Ile           
                55                  60                  65                

tgt gtg gtg aaa att atc cgg cga aca gac aag act gaa att aag gaa        598
Cys Val Val Lys Ile Ile Arg Arg Thr Asp Lys Thr Glu Ile Lys Glu           
            70                  75                  80                    

gcc ttc tta gcg gtg tcc ttg gct ctt gct ttg aat gga gtc tgc aca        646
Ala Phe Leu Ala Val Ser Leu Ala Leu Ala Leu Asn Gly Val Cys Thr           
        85                  90                  95                        

aac act att aaa tta ata gtg gga aga cct cgc ccc gat ttc ttt tac        694
Asn Thr Ile Lys Leu Ile Val Gly Arg Pro Arg Pro Asp Phe Phe Tyr           
    100                 105                 110                           

cgc tgc ttt cca gat gga gtg atg aac tcg gaa atg cat tgc aca ggt        742
Arg Cys Phe Pro Asp Gly Val Met Asn Ser Glu Met His Cys Thr Gly           
115                 120                 125                 130           

gac ccc gat ctg gtg tcc gag ggc cgc aaa agc ttc ccc agc atc cat        790
Asp Pro Asp Leu Val Ser Glu Gly Arg Lys Ser Phe Pro Ser Ile His           
                135                 140                 145               

tcc tcc ttt gcc ttt tcg ggc ctt ggc ttc acg acg ttc tac ttg gcg        838
Ser Ser Phe Ala Phe Ser Gly Leu Gly Phe Thr Thr Phe Tyr Leu Ala           
            150                 155                 160                   

ggc aag ctg cac tgc ttc acc gag agt ggg cgg gga aag agc tgg cgg        886
Gly Lys Leu His Cys Phe Thr Glu Ser Gly Arg Gly Lys Ser Trp Arg           
        165                 170                 175                       

ctc tgt gct gcc atc ctg ccc ttg tac tgc gcc atg atg att gcc ctg        934
Leu Cys Ala Ala Ile Leu Pro Leu Tyr Cys Ala Met Met Ile Ala Leu           
    180                 185                 190                           

tcc cgc atg tgc gac tac aag cat cac tgg caa gat tcc ttt gtg ggt        982
Ser Arg Met Cys Asp Tyr Lys His His Trp Gln Asp Ser Phe Val Gly           
195                 200                 205                 210           

gga gtc atc ggc ctc att ttt gca tac att tgc tac aga cag cac tat       1030
Gly Val Ile Gly Leu Ile Phe Ala Tyr Ile Cys Tyr Arg Gln His Tyr           
                215                 220                 225               

cct cct ctg gcc aac aca gct tgc cat aaa ccc tac gtt agt ctg cga       1078
Pro Pro Leu Ala Asn Thr Ala Cys His Lys Pro Tyr Val Ser Leu Arg           
            230                 235                 240                   

gtc cca gcc tca ctg aag aaa gag gag agg ccc aca gct gac agc gca       1126
Val Pro Ala Ser Leu Lys Lys Glu Glu Arg Pro Thr Ala Asp Ser Ala           
        245                 250                 255                       

ccc agc ttg cct ctg gag ggg atc acc gaa ggc ccg gta tga               1168
Pro Ser Leu Pro Leu Glu Gly Ile Thr Glu Gly Pro Val                       
    260                 265                 270                           

ccagtgtcct gggaggatgg acactaagcc ctgggcacat ctgccaccct gacatcataa     1228

cacaatagaa atggttttct gtagtgtatt tttcatcagt tgtttctcaa agtcatcgta     1288

cttctgcttc tgtttcactg atggtgttcc tgctacttta aatgtctact tccaacatcc     1348

ttgaatttgc aagtgaagga caacaatctc tgagagacgt gtggaagagg ctgtgaaggt     1408

ggggtttggg gagcttggcc gattcgtcta tctgaaatgt ttgctgtaac agccaccttc     1468

ctatgttttc atggttgtaa aacataataa aacctcccac gtggaagact tgg            1521


<210>  254
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Arg Glu Leu Ala Ile Glu Ile Gly Val Arg Ala Leu Leu Phe Gly 
1               5                   10                  15      


Val Phe Val Phe Thr Glu Phe Leu Asp Pro Phe Gln Arg Val Ile Gln 
            20                  25                  30          


Pro Glu Glu Ile Trp Leu Tyr Lys Asn Pro Leu Val Gln Ser Asp Asn 
        35                  40                  45              


Ile Pro Thr Arg Leu Met Phe Ala Ile Ser Phe Leu Thr Pro Leu Ala 
    50                  55                  60                  


Val Ile Cys Val Val Lys Ile Ile Arg Arg Thr Asp Lys Thr Glu Ile 
65                  70                  75                  80  


Lys Glu Ala Phe Leu Ala Val Ser Leu Ala Leu Ala Leu Asn Gly Val 
                85                  90                  95      


Cys Thr Asn Thr Ile Lys Leu Ile Val Gly Arg Pro Arg Pro Asp Phe 
            100                 105                 110         


Phe Tyr Arg Cys Phe Pro Asp Gly Val Met Asn Ser Glu Met His Cys 
        115                 120                 125             


Thr Gly Asp Pro Asp Leu Val Ser Glu Gly Arg Lys Ser Phe Pro Ser 
    130                 135                 140                 


Ile His Ser Ser Phe Ala Phe Ser Gly Leu Gly Phe Thr Thr Phe Tyr 
145                 150                 155                 160 


Leu Ala Gly Lys Leu His Cys Phe Thr Glu Ser Gly Arg Gly Lys Ser 
                165                 170                 175     


Trp Arg Leu Cys Ala Ala Ile Leu Pro Leu Tyr Cys Ala Met Met Ile 
            180                 185                 190         


Ala Leu Ser Arg Met Cys Asp Tyr Lys His His Trp Gln Asp Ser Phe 
        195                 200                 205             


Val Gly Gly Val Ile Gly Leu Ile Phe Ala Tyr Ile Cys Tyr Arg Gln 
    210                 215                 220                 


His Tyr Pro Pro Leu Ala Asn Thr Ala Cys His Lys Pro Tyr Val Ser 
225                 230                 235                 240 


Leu Arg Val Pro Ala Ser Leu Lys Lys Glu Glu Arg Pro Thr Ala Asp 
                245                 250                 255     


Ser Ala Pro Ser Leu Pro Leu Glu Gly Ile Thr Glu Gly Pro Val 
            260                 265                 270     


<210>  255
<211>  1407
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (97)..(846)

<400>  255
ctctccccgg cccgatccgc ccgccggctc cccctccccc gatccctcgg gtcccgggat       60

gggggggcgg tgaggcaggc acagcccccc gccccc atg gcc gcc cgt cgg agc        114
                                        Met Ala Ala Arg Arg Ser           
                                        1               5                 

cag agg cgg agg ggg cgc cgg ggg gag ccg ggc acc gcc ctg ctg gtc        162
Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro Gly Thr Ala Leu Leu Val           
            10                  15                  20                    

ccg ctc gcg ctg ggc ctg ggc ctg gcg ctg gcc tgc ctc ggc ctc ctg        210
Pro Leu Ala Leu Gly Leu Gly Leu Ala Leu Ala Cys Leu Gly Leu Leu           
        25                  30                  35                        

ctg gcc gtg gtc agt ttg ggg agc cgg gca tcg ctg tcc gcc cag gag        258
Leu Ala Val Val Ser Leu Gly Ser Arg Ala Ser Leu Ser Ala Gln Glu           
    40                  45                  50                            

cct gcc cag gag gag ctg gtg gca gag gag gac cag gac ccg tcg gaa        306
Pro Ala Gln Glu Glu Leu Val Ala Glu Glu Asp Gln Asp Pro Ser Glu           
55                  60                  65                  70            

ctg aat ccc cag aca gaa gaa agc cag gat cct gcg cct ttc ctg aac        354
Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp Pro Ala Pro Phe Leu Asn           
                75                  80                  85                

cga cta gtt cgg cct cgc aga agt gca cct aaa ggc cgg aaa aca cgg        402
Arg Leu Val Arg Pro Arg Arg Ser Ala Pro Lys Gly Arg Lys Thr Arg           
            90                  95                  100                   

gct cga aga gcg atc gca gcc cat tat gaa gtt cat cca cga cct gga        450
Ala Arg Arg Ala Ile Ala Ala His Tyr Glu Val His Pro Arg Pro Gly           
        105                 110                 115                       

cag gac gga gcg cag gca ggt gtg gac ggg aca gtg agt ggc tgg gag        498
Gln Asp Gly Ala Gln Ala Gly Val Asp Gly Thr Val Ser Gly Trp Glu           
    120                 125                 130                           

gaa gcc aga atc aac agc tcc agc cct ctg cgc tac aac cgc cag atc        546
Glu Ala Arg Ile Asn Ser Ser Ser Pro Leu Arg Tyr Asn Arg Gln Ile           
135                 140                 145                 150           

ggg gag ttt ata gtc acc cgg gct ggg ctc tac tac ctg tac tgt cag        594
Gly Glu Phe Ile Val Thr Arg Ala Gly Leu Tyr Tyr Leu Tyr Cys Gln           
                155                 160                 165               

gtg cac ttt gat gag ggg aag gct gtc tac ctg aag ctg gac ttg ctg        642
Val His Phe Asp Glu Gly Lys Ala Val Tyr Leu Lys Leu Asp Leu Leu           
            170                 175                 180                   

gtg gat ggt gtg ctg gcc ctg cgc tgc ctg gag gaa ttc tca gcc act        690
Val Asp Gly Val Leu Ala Leu Arg Cys Leu Glu Glu Phe Ser Ala Thr           
        185                 190                 195                       

gcg gcg agt tcc ctc ggg ccc cag ctc cgc ctc tgc cag gtg tct ggg        738
Ala Ala Ser Ser Leu Gly Pro Gln Leu Arg Leu Cys Gln Val Ser Gly           
    200                 205                 210                           

ctg ttg gcc ctg cgg cca ggg tcc tcc ctg cgg atc cgc acc ctc ccc        786
Leu Leu Ala Leu Arg Pro Gly Ser Ser Leu Arg Ile Arg Thr Leu Pro           
215                 220                 225                 230           

tgg gcc cat ctc aag gct gcc ccc ttc ctc acc tac ttc gga ctc ttc        834
Trp Ala His Leu Lys Ala Ala Pro Phe Leu Thr Tyr Phe Gly Leu Phe           
                235                 240                 245               

cag gtt cac tga ggggccctgg tctccccgca gtcgtcccag gctgccggct            886
Gln Val His                                                               
                                                                          

cccctcgaca gctctctggg cacccggtcc cctctgcccc accctcagcc gctctttgct      946

ccagacctgc ccctccctct agaggctgcc tgggcctgtt cacgtgtttt ccatcccaca     1006

taaatacagt attcccactc ttatcttaca actcccccac cgcccactct ccacctcact     1066

agctccccaa tccctgaccc tttgaggccc ccagtgatct cgactccccc ctggccacag     1126

acccccaggg cattgtgttc actgtactct gtgggcaagg atgggtccag aagaccccac     1186

ttcaggcact aagaggggct ggacctggcg gcaggaagcc aaagagactg ggcctaggcc     1246

aggagttccc aaatgtgagg ggcgagaaac aagacaagct cctcccttga gaattccctg     1306

tggattttta aaacagatat tatttttatt attattgtga caaaatgttg ataaatggat     1366

attaaataga ataagtcata aaaaaaaaaa aaaaaaaaaa a                         1407


<210>  256
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro 
1               5                   10                  15      


Gly Thr Ala Leu Leu Val Pro Leu Ala Leu Gly Leu Gly Leu Ala Leu 
            20                  25                  30          


Ala Cys Leu Gly Leu Leu Leu Ala Val Val Ser Leu Gly Ser Arg Ala 
        35                  40                  45              


Ser Leu Ser Ala Gln Glu Pro Ala Gln Glu Glu Leu Val Ala Glu Glu 
    50                  55                  60                  


Asp Gln Asp Pro Ser Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp 
65                  70                  75                  80  


Pro Ala Pro Phe Leu Asn Arg Leu Val Arg Pro Arg Arg Ser Ala Pro 
                85                  90                  95      


Lys Gly Arg Lys Thr Arg Ala Arg Arg Ala Ile Ala Ala His Tyr Glu 
            100                 105                 110         


Val His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly 
        115                 120                 125             


Thr Val Ser Gly Trp Glu Glu Ala Arg Ile Asn Ser Ser Ser Pro Leu 
    130                 135                 140                 


Arg Tyr Asn Arg Gln Ile Gly Glu Phe Ile Val Thr Arg Ala Gly Leu 
145                 150                 155                 160 


Tyr Tyr Leu Tyr Cys Gln Val His Phe Asp Glu Gly Lys Ala Val Tyr 
                165                 170                 175     


Leu Lys Leu Asp Leu Leu Val Asp Gly Val Leu Ala Leu Arg Cys Leu 
            180                 185                 190         


Glu Glu Phe Ser Ala Thr Ala Ala Ser Ser Leu Gly Pro Gln Leu Arg 
        195                 200                 205             


Leu Cys Gln Val Ser Gly Leu Leu Ala Leu Arg Pro Gly Ser Ser Leu 
    210                 215                 220                 


Arg Ile Arg Thr Leu Pro Trp Ala His Leu Lys Ala Ala Pro Phe Leu 
225                 230                 235                 240 


Thr Tyr Phe Gly Leu Phe Gln Val His 
                245                 


<210>  257
<211>  2640
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (41)..(637)

<400>  257
actcgccgca gcctgcgcgc cttctccagt ccgcggtgcc atg gcc ccc gcc cgt         55
                                            Met Ala Pro Ala Arg           
                                            1               5             

ctg ttc gcg ctg ctg ctg ttc ttc gta ggc gga gtc gcc gag tcg atc        103
Leu Phe Ala Leu Leu Leu Phe Phe Val Gly Gly Val Ala Glu Ser Ile           
                10                  15                  20                

cga gag act gag gtc atc gac ccc cag gac ctc cta gaa ggc cga tac        151
Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu Leu Glu Gly Arg Tyr           
            25                  30                  35                    

ttc tcc gga gcc cta cca gac gat gag gat gta gtg ggg ccc ggg cag        199
Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val Val Gly Pro Gly Gln           
        40                  45                  50                        

gaa tct gat gac ttt gag ctg tct ggc tct gga gat ctg gat gac ttg        247
Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly Asp Leu Asp Asp Leu           
    55                  60                  65                            

gaa gac tcc atg atc ggc cct gaa gtt gtc cat ccc ttg gtg cct cta        295
Glu Asp Ser Met Ile Gly Pro Glu Val Val His Pro Leu Val Pro Leu           
70                  75                  80                  85            

gat aac cat atc cct gag agg gca ggg tct ggg agc caa gtc ccc acc        343
Asp Asn His Ile Pro Glu Arg Ala Gly Ser Gly Ser Gln Val Pro Thr           
                90                  95                  100               

gaa ccc aag aaa cta gag gag aat gag gtt atc ccc aag aga atc tca        391
Glu Pro Lys Lys Leu Glu Glu Asn Glu Val Ile Pro Lys Arg Ile Ser           
            105                 110                 115                   

ccc gtt gaa gag agt gag gat gtg tcc aac aag gtg tca atg tcc agc        439
Pro Val Glu Glu Ser Glu Asp Val Ser Asn Lys Val Ser Met Ser Ser           
        120                 125                 130                       

act gtg cag ggc agc aac atc ttt gag aga acg gag gtc ctg gca gct        487
Thr Val Gln Gly Ser Asn Ile Phe Glu Arg Thr Glu Val Leu Ala Ala           
    135                 140                 145                           

ctg att gtg ggt ggc atc gtg ggc atc ctc ttt gcc gtc ttc ctg atc        535
Leu Ile Val Gly Gly Ile Val Gly Ile Leu Phe Ala Val Phe Leu Ile           
150                 155                 160                 165           

cta ctg ctc atg tac cgt atg aag aag aag gat gaa ggc agc tat gac        583
Leu Leu Leu Met Tyr Arg Met Lys Lys Lys Asp Glu Gly Ser Tyr Asp           
                170                 175                 180               

ctg ggc aag aaa ccc atc tac aag aaa gcc ccc acc aat gag ttc tac        631
Leu Gly Lys Lys Pro Ile Tyr Lys Lys Ala Pro Thr Asn Glu Phe Tyr           
            185                 190                 195                   

gcg tga agcttgcttg tgggcactgg cttggacttt agcggggagg gaagccaggg         687
Ala                                                                       
                                                                          

gattttgaag ggtggacatt agggtagggt gaggtcaacc taatactgac ttgtcagtat      747

ctccagctct gattaccttt gaagtgttca gaagagacat tgtcttctac tgttctgcca      807

ggttcttctt gagctttggg cctcagttgc cctggcagaa aaatggattc aacttggcct      867

ttctgaaggc aagactggga ttggatcact tcttaaactt ccagttaaga atctaggtcc      927

gccctcaagc ccatactgac catgcctcat ccagagctcc tctgaagcca gggggctaac      987

ggatgttgtg tggagtcctg gctggaggtc ctcccccagt ggccttcctc ccttcctttc     1047

acagccggtc tctctgccag gaaatggggg aaggaactag aaccacctgc accttgagat     1107

gtttctgtaa atgggtactt gtgatcacac tacgggaatc tctgtggtat atacctgggg     1167

ccattctagg ctctttcaag tgacttttgg aaatcaacct tttttatttg ggggggagga     1227

tggggaaaag agctgagagt ttatgctgaa atggatttat agaatatttg taaatctatt     1287

tttagtgttt gttcgttttt ttaactgttc attcctttgt gcagagtgta tatctctgcc     1347

tgggcaagag tgtggaggtg ccgaggtgtc ttcattctct cgcacatttc cacagcacct     1407

gctaagtttg tatttaatgg tttttgtttt tgtttttgtt tgtttcttga aaatgagaga     1467

agagccggag agatgatttt tattaatttt tttttttttt tttttttttt actatttata     1527

gctttagata gggcctccct tcccctcttc tttctttgtt ctctttcatt aaaccccttc     1587

cccagttttt tttttatact ttaaaccccg ctcctcatgg ccttggccct ttctgaagct     1647

gcttcctctt ataaaatagc ttttgccgaa acatagtttt tttttagcag atcccaaaat     1707

ataatgaagg ggatggtggg atatttgtgt ctgtgttctt ataatatatt attattcttc     1767

cttggttcta gaaaaataga taaatatatt tttttcagga aatagtgtgg tgtttccagt     1827

ttgatgttgc tgggtggttg agtgagtgaa ttttcatgtg gctgggtggg tttttgcctt     1887

tttctcttgc cctgttcctg gtgccttctg atggggctgg aatagttgag gtggatggtt     1947

ctaccctttc tgccttctgt ttgggaccca gctggtgttc tttggtttgc tttcttcagg     2007

ctctagggct gtgctatcca atacagtaac cacatgcggc tgtttaaagt taagccaatt     2067

aaaatcacat aagattaaaa attccttcct cagttgcact aaccacgttt ctagaggcgt     2127

cactgtatgt agttcatggc tactgtactg acagcgagag catgtccatc tgttggacag     2187

cactattcta gagaactaaa ctggcttaac gagtcacagc ctcagctgtg ctgggacgac     2247

ccttgtctcc ctgggtaggg gggggggaat gggggagggc tgatgaggcc ccagctgggg     2307

cctgttgtct gggaccctcc ctctcctgag aggggaggcc tggtggctta gcctgggcag     2367

gtcgtgtctc ctcctgaccc cagtggctgc ggtgagggga accaccctcc cttgctgcac     2427

cagtggccat tagctcccgt caccactgca acccagggtc ccagctggct gggtcctctt     2487

ctgcccccag tgcccttccc cttgggctgt gttggagtga gcacctcctc tgtaggcacc     2547

tctcacactg ttgtctgtta ctgatttttt ttgataaaaa gataataaaa cctggtactt     2607

tctaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                  2640


<210>  258
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Ala Pro Ala Arg Leu Phe Ala Leu Leu Leu Phe Phe Val Gly Gly 
1               5                   10                  15      


Val Ala Glu Ser Ile Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu 
            20                  25                  30          


Leu Glu Gly Arg Tyr Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val 
        35                  40                  45              


Val Gly Pro Gly Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly 
    50                  55                  60                  


Asp Leu Asp Asp Leu Glu Asp Ser Met Ile Gly Pro Glu Val Val His 
65                  70                  75                  80  


Pro Leu Val Pro Leu Asp Asn His Ile Pro Glu Arg Ala Gly Ser Gly 
                85                  90                  95      


Ser Gln Val Pro Thr Glu Pro Lys Lys Leu Glu Glu Asn Glu Val Ile 
            100                 105                 110         


Pro Lys Arg Ile Ser Pro Val Glu Glu Ser Glu Asp Val Ser Asn Lys 
        115                 120                 125             


Val Ser Met Ser Ser Thr Val Gln Gly Ser Asn Ile Phe Glu Arg Thr 
    130                 135                 140                 


Glu Val Leu Ala Ala Leu Ile Val Gly Gly Ile Val Gly Ile Leu Phe 
145                 150                 155                 160 


Ala Val Phe Leu Ile Leu Leu Leu Met Tyr Arg Met Lys Lys Lys Asp 
                165                 170                 175     


Glu Gly Ser Tyr Asp Leu Gly Lys Lys Pro Ile Tyr Lys Lys Ala Pro 
            180                 185                 190         


Thr Asn Glu Phe Tyr Ala 
        195             


<210>  259
<211>  1000
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (186)..(857)

<400>  259
agggagacgc ctagaagatg gaggcccaga ttcttgagac gtttctcttt ctgatctagc       60

aggagggaca aagagctcct ccactccctc attccccaag aaggccccca gcctacccag      120

tttccgtgac cattccgccc tgggaaagcg gcttcccaga cctccttatc tatttttctt      180

gaatc atg aga gat gaa att gca aca aca gtt ttc ttt gtc aca aga ttg      230
      Met Arg Asp Glu Ile Ala Thr Thr Val Phe Phe Val Thr Arg Leu         
      1               5                   10                  15          

gtg aaa aaa cat gat aaa cta agt aaa cag caa ata gaa gac ttt gca        278
Val Lys Lys His Asp Lys Leu Ser Lys Gln Gln Ile Glu Asp Phe Ala           
                20                  25                  30                

gaa aag ctg atg acg atc ttg ttt gaa aca tac aga agt cac tgg cac        326
Glu Lys Leu Met Thr Ile Leu Phe Glu Thr Tyr Arg Ser His Trp His           
            35                  40                  45                    

tct gat tgc cct tct aaa ggg caa gcc ttc agg tgc atc agg ata aac        374
Ser Asp Cys Pro Ser Lys Gly Gln Ala Phe Arg Cys Ile Arg Ile Asn           
        50                  55                  60                        

aac aat cag aat aaa gat ccc att cta gaa agg gca tgt gtg gaa agt        422
Asn Asn Gln Asn Lys Asp Pro Ile Leu Glu Arg Ala Cys Val Glu Ser           
    65                  70                  75                            

aat gta gat ttt tct cac ctg gga ctt ccg aag gag atg acc ata tgg        470
Asn Val Asp Phe Ser His Leu Gly Leu Pro Lys Glu Met Thr Ile Trp           
80                  85                  90                  95            

gta gat ccc ttt gaa gta tgc tgt agg tat ggt gag aaa aac cat cca        518
Val Asp Pro Phe Glu Val Cys Cys Arg Tyr Gly Glu Lys Asn His Pro           
                100                 105                 110               

ttt aca gtt gct tct ttt aaa ggc aga tgg gag gaa tgg gaa cta tat        566
Phe Thr Val Ala Ser Phe Lys Gly Arg Trp Glu Glu Trp Glu Leu Tyr           
            115                 120                 125                   

caa caa atc agt tat gcc gtt agt aga gcc tca tca gac gtt tcc tct        614
Gln Gln Ile Ser Tyr Ala Val Ser Arg Ala Ser Ser Asp Val Ser Ser           
        130                 135                 140                       

ggc act tcc tgc gat gaa gaa agt tgt agc aag gaa cct cgt gtc att        662
Gly Thr Ser Cys Asp Glu Glu Ser Cys Ser Lys Glu Pro Arg Val Ile           
    145                 150                 155                           

cct aaa gtc agc aat ccg aag agt att tat cag gtt gaa aac ttg aaa        710
Pro Lys Val Ser Asn Pro Lys Ser Ile Tyr Gln Val Glu Asn Leu Lys           
160                 165                 170                 175           

cag ccc ttt caa tct tgg tta caa atc ccc cgc aaa aag aat gtg gtg        758
Gln Pro Phe Gln Ser Trp Leu Gln Ile Pro Arg Lys Lys Asn Val Val           
                180                 185                 190               

gac ggc cgt gtt ggc ctc ctg gga aac act tac cat ggc tcg cag aag        806
Asp Gly Arg Val Gly Leu Leu Gly Asn Thr Tyr His Gly Ser Gln Lys           
            195                 200                 205                   

cat cct aag tgt tac agg cct gct atg cac cgg ctg gac aga att tta        854
His Pro Lys Cys Tyr Arg Pro Ala Met His Arg Leu Asp Arg Ile Leu           
        210                 215                 220                       

taa cccacatctg ggaatgaatt tgcagcacct ggtagaagaa ggcaccttgg             907

aaggcactgc cttgggcttc catggcagga agatgagaag aaatcttcag ggtgatttct      967

ggagcctgaa aagaataaaa aacaaaacca aaa                                  1000


<210>  260
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Arg Asp Glu Ile Ala Thr Thr Val Phe Phe Val Thr Arg Leu Val 
1               5                   10                  15      


Lys Lys His Asp Lys Leu Ser Lys Gln Gln Ile Glu Asp Phe Ala Glu 
            20                  25                  30          


Lys Leu Met Thr Ile Leu Phe Glu Thr Tyr Arg Ser His Trp His Ser 
        35                  40                  45              


Asp Cys Pro Ser Lys Gly Gln Ala Phe Arg Cys Ile Arg Ile Asn Asn 
    50                  55                  60                  


Asn Gln Asn Lys Asp Pro Ile Leu Glu Arg Ala Cys Val Glu Ser Asn 
65                  70                  75                  80  


Val Asp Phe Ser His Leu Gly Leu Pro Lys Glu Met Thr Ile Trp Val 
                85                  90                  95      


Asp Pro Phe Glu Val Cys Cys Arg Tyr Gly Glu Lys Asn His Pro Phe 
            100                 105                 110         


Thr Val Ala Ser Phe Lys Gly Arg Trp Glu Glu Trp Glu Leu Tyr Gln 
        115                 120                 125             


Gln Ile Ser Tyr Ala Val Ser Arg Ala Ser Ser Asp Val Ser Ser Gly 
    130                 135                 140                 


Thr Ser Cys Asp Glu Glu Ser Cys Ser Lys Glu Pro Arg Val Ile Pro 
145                 150                 155                 160 


Lys Val Ser Asn Pro Lys Ser Ile Tyr Gln Val Glu Asn Leu Lys Gln 
                165                 170                 175     


Pro Phe Gln Ser Trp Leu Gln Ile Pro Arg Lys Lys Asn Val Val Asp 
            180                 185                 190         


Gly Arg Val Gly Leu Leu Gly Asn Thr Tyr His Gly Ser Gln Lys His 
        195                 200                 205             


Pro Lys Cys Tyr Arg Pro Ala Met His Arg Leu Asp Arg Ile Leu 
    210                 215                 220             


<210>  261
<211>  3387
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (266)..(1570)

<400>  261
gaagaactgg aactggtctg gccatagggg gaagcggcgc gttaaatccg ccccctctcc       60

ataccctact ttcaaggggt gggcggtaga ggggaggttg gggttggagc agcggcgagg      120

gggcccctcc cttgcacctc cccccaccgg acttggtcgc gcccgaagtg taacactttc      180

tctttgtcgg aggagctcct ctgtttcctg tgcagtagct cccgttgcgg cggcacccgt      240

ggcagccctg gcggacgcag gagcg atg gca gcg acc gat ata gct cgc cag        292
                            Met Ala Ala Thr Asp Ile Ala Arg Gln           
                            1               5                             

gtg ggt gaa ggt tgc cga act gtc ccc ctg gct gga cat gtg ggg ttt        340
Val Gly Glu Gly Cys Arg Thr Val Pro Leu Ala Gly His Val Gly Phe           
10                  15                  20                  25            

gac agc ttg cct gac cag ctg gtg aat aag tcc gtc agc cag ggc ttc        388
Asp Ser Leu Pro Asp Gln Leu Val Asn Lys Ser Val Ser Gln Gly Phe           
                30                  35                  40                

tgc ttc aac atc ctg tgc gtg gga gag aca ggt ttg ggc aag tcc acc        436
Cys Phe Asn Ile Leu Cys Val Gly Glu Thr Gly Leu Gly Lys Ser Thr           
            45                  50                  55                    

ctc atg gac acc ctg ttc aac acc aaa ttc gaa ggg gag cca gcc acc        484
Leu Met Asp Thr Leu Phe Asn Thr Lys Phe Glu Gly Glu Pro Ala Thr           
        60                  65                  70                        

cac aca cag ccg ggt gtc cag ctc cag tct aat acc tat gac ctc caa        532
His Thr Gln Pro Gly Val Gln Leu Gln Ser Asn Thr Tyr Asp Leu Gln           
    75                  80                  85                            

gag agc aac gtg agg cta aag ctc acg atc gtt agc aca gtt ggc ttt        580
Glu Ser Asn Val Arg Leu Lys Leu Thr Ile Val Ser Thr Val Gly Phe           
90                  95                  100                 105           

ggg gac cag atc aac aaa gag gac agc tac aag cct atc gtg gaa ttc        628
Gly Asp Gln Ile Asn Lys Glu Asp Ser Tyr Lys Pro Ile Val Glu Phe           
                110                 115                 120               

atc gat gca caa ttc gag gcc tac ctg cag gaa gag cta aag atc cga        676
Ile Asp Ala Gln Phe Glu Ala Tyr Leu Gln Glu Glu Leu Lys Ile Arg           
            125                 130                 135                   

aga gtg cta cac acc tac cat gac tcc cga atc cat gtc tgc ttg tat        724
Arg Val Leu His Thr Tyr His Asp Ser Arg Ile His Val Cys Leu Tyr           
        140                 145                 150                       

ttc att gcc ccc acg ggt cat tcc ctg aag tct ctg gac cta gtg act        772
Phe Ile Ala Pro Thr Gly His Ser Leu Lys Ser Leu Asp Leu Val Thr           
    155                 160                 165                           

atg aag aag ctg gac agt aag gtg aac atc atc ccc atc att gcc aaa        820
Met Lys Lys Leu Asp Ser Lys Val Asn Ile Ile Pro Ile Ile Ala Lys           
170                 175                 180                 185           

gca gat gcc att tcg aag agt gag cta aca aag ttc aaa atc aaa atc        868
Ala Asp Ala Ile Ser Lys Ser Glu Leu Thr Lys Phe Lys Ile Lys Ile           
                190                 195                 200               

acc agc gag ctt gtc agc aac gga gtc cag atc tat cag ttt cct aca        916
Thr Ser Glu Leu Val Ser Asn Gly Val Gln Ile Tyr Gln Phe Pro Thr           
            205                 210                 215                   

gat gat gag tcg gtg gca gag atc aat gga acc atg aac gcc cac ctg        964
Asp Asp Glu Ser Val Ala Glu Ile Asn Gly Thr Met Asn Ala His Leu           
        220                 225                 230                       

ccg ttt gct gtc att ggc agc aca gaa gaa ctg aag ata ggc aac aag       1012
Pro Phe Ala Val Ile Gly Ser Thr Glu Glu Leu Lys Ile Gly Asn Lys           
    235                 240                 245                           

atg atg agg gcg cgg cag tat cct tgg ggc act gtg cag gtt gaa aac       1060
Met Met Arg Ala Arg Gln Tyr Pro Trp Gly Thr Val Gln Val Glu Asn           
250                 255                 260                 265           

gag gcc cac tgc gac ttt gtg aag ctg cgg gag atg ctg att cgg gtc       1108
Glu Ala His Cys Asp Phe Val Lys Leu Arg Glu Met Leu Ile Arg Val           
                270                 275                 280               

aac atg gag gat ctg cgg gag cag acc cac acc cgg cac tat gag ctg       1156
Asn Met Glu Asp Leu Arg Glu Gln Thr His Thr Arg His Tyr Glu Leu           
            285                 290                 295                   

tat cgc cgc tgt aag ctg gag gag atg ggc ttc aag gac acc gac cct       1204
Tyr Arg Arg Cys Lys Leu Glu Glu Met Gly Phe Lys Asp Thr Asp Pro           
        300                 305                 310                       

gac agc aaa ccc ttc agt tta cag gag aca tat gag gcc aaa agg aac       1252
Asp Ser Lys Pro Phe Ser Leu Gln Glu Thr Tyr Glu Ala Lys Arg Asn           
    315                 320                 325                           

gag ttc cta ggg gaa ctc cag aaa aaa gaa gag gag atg aga cag atg       1300
Glu Phe Leu Gly Glu Leu Gln Lys Lys Glu Glu Glu Met Arg Gln Met           
330                 335                 340                 345           

ttc gtc cag cga gtc aaa gag aaa gaa gcg gag ctc aaa gag gca gag       1348
Phe Val Gln Arg Val Lys Glu Lys Glu Ala Glu Leu Lys Glu Ala Glu           
                350                 355                 360               

aaa gag ctg cac gag aag ttt gac cgt ctg aag aaa ctg cac cag gac       1396
Lys Glu Leu His Glu Lys Phe Asp Arg Leu Lys Lys Leu His Gln Asp           
            365                 370                 375                   

gag aag aag aaa ctg gag gat aag aag aaa tcc ctg gat gat gaa gtg       1444
Glu Lys Lys Lys Leu Glu Asp Lys Lys Lys Ser Leu Asp Asp Glu Val           
        380                 385                 390                       

aat gct ttc aag caa aga aag acg gcg gct gag ctg ctc cag tcc cag       1492
Asn Ala Phe Lys Gln Arg Lys Thr Ala Ala Glu Leu Leu Gln Ser Gln           
    395                 400                 405                           

ggc tcc cag gct gga ggc tca cag act ctg aag aga gac aaa gag aag       1540
Gly Ser Gln Ala Gly Gly Ser Gln Thr Leu Lys Arg Asp Lys Glu Lys           
410                 415                 420                 425           

aaa aat aat cca tgg ctg tgt act gaa tag tattccccgc tacagctgga         1590
Lys Asn Asn Pro Trp Leu Cys Thr Glu                                       
                430                                                       

ctggactcca tttagccttt taagccgagg ttcctatttt aactgacagc tttcctttgg     1650

ggtgccaggc agcgaggccc cccaccccta tcctgccatg tacttcaagc tcacttcttc     1710

tttttgagtt ccgcaacttg ctcctgcctc ccagccccac tggcactgac catgaccacc     1770

tacttctatt ttttttttag agtttctttt tttgatcact tactttcaaa gcacacagtc     1830

aaacaaggtt atgccaaatt tccaggcctt tttgaagtat tgagaagggg aaggggattt     1890

ctcacttcaa ttatagatca taataggaag caaaaagaaa aaaatgaaaa gcaaacatat     1950

gcacgcactt ttcttgttga caaagcaaga atataggttt gctgtgtagg tttggtgctc     2010

tattgattgg tgagtgacca gagcaagtat gaaggtgatg ctgccaaagc acaagccagt     2070

ttcttgggaa aattcaagtt acagtggagt atttttttga agaccatatg cttggaggta     2130

gaaacaaacc aacgaccaaa aaaaaaaaaa aaaaaatctg ctcagatact cagccagtag     2190

ctcagagaga tgctgagtta ggcctgtcag gtctccttgg gaaaggcttc atatttgcaa     2250

ctttgatgat tctatgtcca gcttcagagc tgctttccca gaaattcacg cttaaacaac     2310

caaccggtaa ccaccacttc cccacaccgc cgcccggtaa ttatttgcat tacaaaccgg     2370

aggcgccctc atttgcattt gtgtacagat taactagtta aggcttgaga agctctgaat     2430

aattcaaaag tattagaccc acacagcctt ggagagacct tcagaaacta aggaggagtt     2490

ttatattaag ggagacattt tagtcagtaa gacgatataa cctacttact ccgtaagggg     2550

aaatgaaggc ccagagaagg gaagggactt gaccgaggtc ccacttctgt ttcgaggcag     2610

aagccagact aattttcatg cctcctgact cccaatcagt ttcacaaagg gattcaatct     2670

gtttatatac gttacattcc tggatacgag gtcttttgat gttcagagta actgactagt     2730

tagtattaga agaccctcga ggtttttttc cacagaaaaa catctgaaga tggattgggt     2790

gagggctggc aaaacgaagg catgccgggc cagctcctta acccaatgac ccagtgatgc     2850

tgcaaggctg gaacggggtc caggagactg tgtgtaacag gtgccctagg tgacccttat     2910

aatcagggaa gtttggtgaa caaaaatcga acccatgagt gaacataaat taaaaagttg     2970

atcaacctat taaaatgtgt atttcattgg gtagcttttc tcactgtaga cagatttttt     3030

ccttcttcaa tgaaaaggct tttaaattag tacaactgtt actatttaaa aaaaaaatac     3090

cctaagtact ctgtttactt ctggtgaaac aaaaccagtc attagaaatg gtctgtgctt     3150

ttattttccc agactggagt ggcttttctg aaacacacac acacacacac acacacacac     3210

acacacacac acacacacac acgtacacac atccctcact tctcttaagc caagaagttt     3270

gctttcccta gctgcagtgt agatggctct tgtttttgtt tttttgtttt aatcatttgg     3330

cattcacatg tggctgttaa tatgtgcttg tttttaatta aaacaagaag ctttaaa        3387


<210>  262
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Ala Ala Thr Asp Ile Ala Arg Gln Val Gly Glu Gly Cys Arg Thr 
1               5                   10                  15      


Val Pro Leu Ala Gly His Val Gly Phe Asp Ser Leu Pro Asp Gln Leu 
            20                  25                  30          


Val Asn Lys Ser Val Ser Gln Gly Phe Cys Phe Asn Ile Leu Cys Val 
        35                  40                  45              


Gly Glu Thr Gly Leu Gly Lys Ser Thr Leu Met Asp Thr Leu Phe Asn 
    50                  55                  60                  


Thr Lys Phe Glu Gly Glu Pro Ala Thr His Thr Gln Pro Gly Val Gln 
65                  70                  75                  80  


Leu Gln Ser Asn Thr Tyr Asp Leu Gln Glu Ser Asn Val Arg Leu Lys 
                85                  90                  95      


Leu Thr Ile Val Ser Thr Val Gly Phe Gly Asp Gln Ile Asn Lys Glu 
            100                 105                 110         


Asp Ser Tyr Lys Pro Ile Val Glu Phe Ile Asp Ala Gln Phe Glu Ala 
        115                 120                 125             


Tyr Leu Gln Glu Glu Leu Lys Ile Arg Arg Val Leu His Thr Tyr His 
    130                 135                 140                 


Asp Ser Arg Ile His Val Cys Leu Tyr Phe Ile Ala Pro Thr Gly His 
145                 150                 155                 160 


Ser Leu Lys Ser Leu Asp Leu Val Thr Met Lys Lys Leu Asp Ser Lys 
                165                 170                 175     


Val Asn Ile Ile Pro Ile Ile Ala Lys Ala Asp Ala Ile Ser Lys Ser 
            180                 185                 190         


Glu Leu Thr Lys Phe Lys Ile Lys Ile Thr Ser Glu Leu Val Ser Asn 
        195                 200                 205             


Gly Val Gln Ile Tyr Gln Phe Pro Thr Asp Asp Glu Ser Val Ala Glu 
    210                 215                 220                 


Ile Asn Gly Thr Met Asn Ala His Leu Pro Phe Ala Val Ile Gly Ser 
225                 230                 235                 240 


Thr Glu Glu Leu Lys Ile Gly Asn Lys Met Met Arg Ala Arg Gln Tyr 
                245                 250                 255     


Pro Trp Gly Thr Val Gln Val Glu Asn Glu Ala His Cys Asp Phe Val 
            260                 265                 270         


Lys Leu Arg Glu Met Leu Ile Arg Val Asn Met Glu Asp Leu Arg Glu 
        275                 280                 285             


Gln Thr His Thr Arg His Tyr Glu Leu Tyr Arg Arg Cys Lys Leu Glu 
    290                 295                 300                 


Glu Met Gly Phe Lys Asp Thr Asp Pro Asp Ser Lys Pro Phe Ser Leu 
305                 310                 315                 320 


Gln Glu Thr Tyr Glu Ala Lys Arg Asn Glu Phe Leu Gly Glu Leu Gln 
                325                 330                 335     


Lys Lys Glu Glu Glu Met Arg Gln Met Phe Val Gln Arg Val Lys Glu 
            340                 345                 350         


Lys Glu Ala Glu Leu Lys Glu Ala Glu Lys Glu Leu His Glu Lys Phe 
        355                 360                 365             


Asp Arg Leu Lys Lys Leu His Gln Asp Glu Lys Lys Lys Leu Glu Asp 
    370                 375                 380                 


Lys Lys Lys Ser Leu Asp Asp Glu Val Asn Ala Phe Lys Gln Arg Lys 
385                 390                 395                 400 


Thr Ala Ala Glu Leu Leu Gln Ser Gln Gly Ser Gln Ala Gly Gly Ser 
                405                 410                 415     


Gln Thr Leu Lys Arg Asp Lys Glu Lys Lys Asn Asn Pro Trp Leu Cys 
            420                 425                 430         


Thr Glu 
        


<210>  263
<211>  1182
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (105)..(599)

<400>  263
ggttcctccc cactctgtct ttctcacctc tccttcactt ttcctagcct cctcaccacc       60

atctgatcta tcttgttctc ttcacaaaag gctctgaaga catc atg aac cca caa       116
                                                 Met Asn Pro Gln          
                                                 1                        

cgg gag gca gca ccc aaa tcc tat gct att cgt gat tct cga cag atg        164
Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp Ser Arg Gln Met           
5                   10                  15                  20            

gtg tgg gtc ctg agt gga aat tct tta ata gca gct cct ctt agc cgc        212
Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala Pro Leu Ser Arg           
                25                  30                  35                

agc att aag cct gtc act ctt cat tta ata gcc tgt aga gac aca gaa        260
Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys Arg Asp Thr Glu           
            40                  45                  50                    

ttc agt gac aag gaa aag ggt aat atg gtt tac ctg gga atc aag gga        308
Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu Gly Ile Lys Gly           
        55                  60                  65                        

aaa gat ctc tgt ctc ttc tgt gca gaa att cag ggc aag cct act ttg        356
Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly Lys Pro Thr Leu           
    70                  75                  80                            

cag ctt aag ctt cag ggc tcc caa gat aac ata ggg aag gac act tgc        404
Gln Leu Lys Leu Gln Gly Ser Gln Asp Asn Ile Gly Lys Asp Thr Cys           
85                  90                  95                  100           

tgg aaa cta gtt gga att cac aca tgc ata aac ctg gat gtg aga gag        452
Trp Lys Leu Val Gly Ile His Thr Cys Ile Asn Leu Asp Val Arg Glu           
                105                 110                 115               

agc tgc ttc atg gga acc ctt gac caa tgg gga ata gga gtg ggt aga        500
Ser Cys Phe Met Gly Thr Leu Asp Gln Trp Gly Ile Gly Val Gly Arg           
            120                 125                 130                   

aag aag tgg aag agt tcc ttt caa cat cac cat ctc agg aag aag gac        548
Lys Lys Trp Lys Ser Ser Phe Gln His His His Leu Arg Lys Lys Asp           
        135                 140                 145                       

aaa gat ttc tca tcc atg cgg acc aac ata gga atg cca gga agg atg        596
Lys Asp Phe Ser Ser Met Arg Thr Asn Ile Gly Met Pro Gly Arg Met           
    150                 155                 160                           

tag aaataagggg aggaagattc ccatctctac aatctttgag tgggtttgct             649

atcaatgaaa tgctacaaat ggaataagtt gcagaaattt ttctcttttc ttgggttctg      709

gagagtttgt aaaacaagga cactatgtat ttttaaagag ttggtaaatc ttacctgtaa      769

agctagagaa ggtcggagtc tttttaggag tagatttgga ctacataacc tgtaaatgtg      829

ttttgtccag tccttagagt gttttttaaa aaattgtaaa gtcaaggttt tcatgaaaaa      889

tgggaagatc agacaacatt gctcctgaat tcccacagag cagcaagcta ctagagctca      949

atctgttatt tcttttcctg atgtacaggg gttaagtcct atggaagaaa cagcagaatt     1009

attcaaaatt atttacataa tgtgcaatta ttcactagag catgaggagt gaaacgctct     1069

gtttagtatg tataacttaa aaggaacaca tacaattaaa agtaattgaa agacatttct     1129

tcttaaaaat tctataatct tacactggta aaataaacta gtttttccca tgt            1182


<210>  264
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  264

Met Asn Pro Gln Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp 
1               5                   10                  15      


Ser Arg Gln Met Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala 
            20                  25                  30          


Pro Leu Ser Arg Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys 
        35                  40                  45              


Arg Asp Thr Glu Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu 
    50                  55                  60                  


Gly Ile Lys Gly Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly 
65                  70                  75                  80  


Lys Pro Thr Leu Gln Leu Lys Leu Gln Gly Ser Gln Asp Asn Ile Gly 
                85                  90                  95      


Lys Asp Thr Cys Trp Lys Leu Val Gly Ile His Thr Cys Ile Asn Leu 
            100                 105                 110         


Asp Val Arg Glu Ser Cys Phe Met Gly Thr Leu Asp Gln Trp Gly Ile 
        115                 120                 125             


Gly Val Gly Arg Lys Lys Trp Lys Ser Ser Phe Gln His His His Leu 
    130                 135                 140                 


Arg Lys Lys Asp Lys Asp Phe Ser Ser Met Arg Thr Asn Ile Gly Met 
145                 150                 155                 160 


Pro Gly Arg Met 
                


<210>  265
<211>  1629
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (60)..(596)

<400>  265
acacatcagg ggcttgctct tgcaaaacca aaccacaaga cagacttgca aaagaaggc        59

atg cac agc tca gca ctg ctc tgt tgc ctg gtc ctc ctg act ggg gtg        107
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val           
1               5                   10                  15                

agg gcc agc cca ggc cag ggc acc cag tct gag aac agc tgc acc cac        155
Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His           
            20                  25                  30                    

ttc cca ggc aac ctg cct aac atg ctt cga gat ctc cga gat gcc ttc        203
Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe           
        35                  40                  45                        

agc aga gtg aag act ttc ttt caa atg aag gat cag ctg gac aac ttg        251
Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu           
    50                  55                  60                            

ttg tta aag gag tcc ttg ctg gag gac ttt aag ggt tac ctg ggt tgc        299
Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys           
65                  70                  75                  80            

caa gcc ttg tct gag atg atc cag ttt tac ctg gag gag gtg atg ccc        347
Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro           
                85                  90                  95                

caa gct gag aac caa gac cca gac atc aag gcg cat gtg aac tcc ctg        395
Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu           
            100                 105                 110                   

ggg gag aac ctg aag acc ctc agg ctg agg cta cgg cgc tgt cat cga        443
Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg           
        115                 120                 125                       

ttt ctt ccc tgt gaa aac aag agc aag gcc gtg gag cag gtg aag aat        491
Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn           
    130                 135                 140                           

gcc ttt aat aag ctc caa gag aaa ggc atc tac aaa gcc atg agt gag        539
Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu           
145                 150                 155                 160           

ttt gac atc ttc atc aac tac ata gaa gcc tac atg aca atg aag ata        587
Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile           
                165                 170                 175               

cga aac tga gacatcaggg tggcgactct atagactcta ggacataaat                636
Arg Asn                                                                   
                                                                          

tagaggtctc caaaatcgga tctggggctc tgggatagct gacccagccc cttgagaaac      696

cttattgtac ctctcttata gaatatttat tacctctgat acctcaaccc ccatttctat      756

ttatttactg agcttctctg tgaacgattt agaaagaagc ccaatattat aatttttttc      816

aatatttatt attttcacct gtttttaagc tgtttccata gggtgacaca ctatggtatt      876

tgagtgtttt aagataaatt ataagttaca taagggagga aaaaaaatgt tctttgggga      936

gccaacagaa gcttccattc caagcctgac cacgctttct agctgttgag ctgttttccc      996

tgacctccct ctaatttatc ttgtctctgg gcttggggct tcctaactgc tacaaatact     1056

cttaggaaga gaaaccaggg agcccctttg atgattaatt caccttccag tgtctcggag     1116

ggattcccct aacctcattc cccaaccact tcattcttga aagctgtggc cagcttgtta     1176

tttataacaa cctaaatttg gttctaggcc gggcgcggtg gctcacgcct gtaatcccag     1236

cactttggga ggctgaggcg ggtggatcac ttgaggtcag gagttcctaa ccagcctggt     1296

caacatggtg aaaccccgtc tctactaaaa atacaaaaat tagccgggca tggtggcgcg     1356

cacctgtaat cccagctact tgggaggctg aggcaagaga attgcttgaa cccaggagat     1416

ggaagttgca gtgagctgat atcatgcccc tgtactccag cctgggtgac agagcaagac     1476

tctgtctcaa aaaataaaaa taaaaataaa tttggttcta atagaactca gttttaacta     1536

gaatttattc aattcctctg ggaatgttac attgtttgtc tgtcttcata gcagatttta     1596

attttgaata aataaatgta tcttattcac atc                                  1629


<210>  266
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  266

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  267
<211>  7171
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (128)..(6121)

<400>  267
atcggagggg ggtcgggagg aggaggagga ggcagcggca gagaagagag aggcgtgtga       60

gccgtgctcc accggctagc tccttcccgc tgctcctgcc tggcagtgcc aggcagccca      120

caccagc atg gcc ttg ctc atc cac ctc aag aca gtc tcg gag ctg cgg        169
        Met Ala Leu Leu Ile His Leu Lys Thr Val Ser Glu Leu Arg           
        1               5                   10                            

ggc agg ggc gac cgg atc gcc aaa gtg act ttc cga ggg caa tcc ttc        217
Gly Arg Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe           
15                  20                  25                  30            

tac tct cgg gtc ctg gag aac tgt gag gat gtg gct gac ttt gat gag        265
Tyr Ser Arg Val Leu Glu Asn Cys Glu Asp Val Ala Asp Phe Asp Glu           
                35                  40                  45                

aca ttt cgg tgg ccg gtg gcc agc agc atc gac aga aat gag atg ctg        313
Thr Phe Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Met Leu           
            50                  55                  60                    

gag att cag gtt ttc aac tac agc aaa gtc ttc agc aac aag ctc atc        361
Glu Ile Gln Val Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile           
        65                  70                  75                        

ggg acc ttc cgc atg gtg ctg cag aag gtg gta gag gag agc cat gtg        409
Gly Thr Phe Arg Met Val Leu Gln Lys Val Val Glu Glu Ser His Val           
    80                  85                  90                            

gag gtg act gac acg ctg att gat gac aac aat gct atc atc aag acc        457
Glu Val Thr Asp Thr Leu Ile Asp Asp Asn Asn Ala Ile Ile Lys Thr           
95                  100                 105                 110           

agc ctg tgc gtg gag gtc cgg tat cag gcc act gac ggc aca gtg ggc        505
Ser Leu Cys Val Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly           
                115                 120                 125               

tcc tgg gac gat ggg gac ttc ctg gga gat gag tct ctt caa gag gaa        553
Ser Trp Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu           
            130                 135                 140                   

gag aag gac agc caa gag acg gat gga ctg ctc cca ggc tcc cgg ccc        601
Glu Lys Asp Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro           
        145                 150                 155                       

agc tcc cgg ccc cca gga gag aag agc ttc cgg aga gcc ggg agg agc        649
Ser Ser Arg Pro Pro Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser           
    160                 165                 170                           

gtg ttc tcc gcc atg aag ctc ggc aaa aac cgg tct cac aag gag gag        697
Val Phe Ser Ala Met Lys Leu Gly Lys Asn Arg Ser His Lys Glu Glu           
175                 180                 185                 190           

ccc caa aga cca gat gaa ccg gcg gtg ctg gag atg gaa gac ctt gac        745
Pro Gln Arg Pro Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp           
                195                 200                 205               

cat ctg gcc att cgg cta gga gat gga ctg gat ccc gac tcg gtg tct        793
His Leu Ala Ile Arg Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser           
            210                 215                 220                   

cta gcc tca gtc aca gct ctc acc act aat gtc tcc aac aag cga tct        841
Leu Ala Ser Val Thr Ala Leu Thr Thr Asn Val Ser Asn Lys Arg Ser           
        225                 230                 235                       

aag cca gac att aag atg gag cca agt gct ggg cgg ccc atg gat tac        889
Lys Pro Asp Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr           
    240                 245                 250                           

cag gtc agc atc acg gtg atc gag gcc cgg cag ctg gtg ggc ttg aac        937
Gln Val Ser Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn           
255                 260                 265                 270           

atg gac cct gtg gtg tgc gtg gag gtg ggt gac gac aag aag tac aca        985
Met Asp Pro Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr           
                275                 280                 285               

tcc atg aag gag tcc act aac tgc ccc tat tac aac gag tac ttc gtc       1033
Ser Met Lys Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val           
            290                 295                 300                   

ttc gac ttc cat gtc tct ccg gat gtc atg ttt gac aag atc atc aag       1081
Phe Asp Phe His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys           
        305                 310                 315                       

att tcg gtg att cac tcc aag aac ctg ctg cgc agt ggc acc ctg gtg       1129
Ile Ser Val Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val           
    320                 325                 330                           

ggc tcc ttc aaa atg gac gtg gga acc gtg tac tcg cag cca gag cac       1177
Gly Ser Phe Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His           
335                 340                 345                 350           

cag ttc cat cac aag tgg gcc atc ctg tct gac ccc gat gac atc tcc       1225
Gln Phe His His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser           
                355                 360                 365               

tcg ggg ctg aag ggc tac gtg aag tgt gac gtt gcc gtg gtg ggc aaa       1273
Ser Gly Leu Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys           
            370                 375                 380                   

ggg gac aac atc aag acg ccc cac aag gcc aat gag acc gac gaa gat       1321
Gly Asp Asn Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp           
        385                 390                 395                       

gac att gag ggg aac ttg ctg ctc ccc gag ggg gtg ccc ccc gaa cgc       1369
Asp Ile Glu Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg           
    400                 405                 410                           

cag tgg gcc cgg ttc tat gtg aaa att tac cga gca gag ggg ctg ccc       1417
Gln Trp Ala Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro           
415                 420                 425                 430           

cgt atg aac aca agc ctc atg gcc aat gta aag aag gct ttc atc ggt       1465
Arg Met Asn Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly           
                435                 440                 445               

gaa aac aag gac ctc gtg gac ccc tac gtg caa gtc ttc ttt gct ggc       1513
Glu Asn Lys Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly           
            450                 455                 460                   

cag aag ggc aag act tca gtg cag aag agc agc tat gag ccc ctg tgg       1561
Gln Lys Gly Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp           
        465                 470                 475                       

aat gag cag gtc gtc ttt aca gac ctc ttc ccc cca ctc tgc aaa cgc       1609
Asn Glu Gln Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg           
    480                 485                 490                           

atg aag gtg cag atc cga gac tcg gac aag gtc aac gac gtg gcc atc       1657
Met Lys Val Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile           
495                 500                 505                 510           

ggc acc cac ttc att gac ctg cgc aag att tct aat gac gga gac aaa       1705
Gly Thr His Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys           
                515                 520                 525               

ggc ttc ctg ccc aca ctg ggc cca gcc tgg gtg aac atg tac ggc tcc       1753
Gly Phe Leu Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser           
            530                 535                 540                   

aca cgt aac tac acg ctg ctg gat gag cat cag gac ctg aac gag ggc       1801
Thr Arg Asn Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly           
        545                 550                 555                       

ctg ggg gag ggt gtg tcc ttc cgg gcc cgg ctc ctg ctg ggc ctg gct       1849
Leu Gly Glu Gly Val Ser Phe Arg Ala Arg Leu Leu Leu Gly Leu Ala           
    560                 565                 570                           

gtg gag atc gta gac acc tcc aac cct gag ctc acc agc tcc aca gag       1897
Val Glu Ile Val Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu           
575                 580                 585                 590           

gtg cag gtg gag cag gcc acg ccc atc tcg gag agc tgt gca ggt aaa       1945
Val Gln Val Glu Gln Ala Thr Pro Ile Ser Glu Ser Cys Ala Gly Lys           
                595                 600                 605               

atg gaa gaa ttc ttt ctc ttt gga gcc ttc ctg gag gcc tca atg atc       1993
Met Glu Glu Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile           
            610                 615                 620                   

gac cgg aga aac gga gac aag ccc atc acc ttt gag gtc acc ata ggc       2041
Asp Arg Arg Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly           
        625                 630                 635                       

aac tat ggg aac gaa gtt gat ggc ctg tcc cgg ccc cag cgg cct cgg       2089
Asn Tyr Gly Asn Glu Val Asp Gly Leu Ser Arg Pro Gln Arg Pro Arg           
    640                 645                 650                           

ccc cgg aag gag ccg ggg gat gag gaa gaa gta gac ctg att cag aac       2137
Pro Arg Lys Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn           
655                 660                 665                 670           

gca agt gat gac gag gcc ggt gat gcc ggg gac ctg gcc tca gtc tcc       2185
Ala Ser Asp Asp Glu Ala Gly Asp Ala Gly Asp Leu Ala Ser Val Ser           
                675                 680                 685               

tcc act cca cca atg cgg ccc cag gtc acc gac agg aac tac ttc cat       2233
Ser Thr Pro Pro Met Arg Pro Gln Val Thr Asp Arg Asn Tyr Phe His           
            690                 695                 700                   

ctg ccc tac ctg gag cga aag ccc tgc atc tac atc aag agc tgg tgg       2281
Leu Pro Tyr Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp           
        705                 710                 715                       

ccg gac cag cgc cgc cgc ctc tac aat gcc aac atc atg gac cac att       2329
Pro Asp Gln Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile           
    720                 725                 730                           

gcc gac aag ctg gaa gaa ggc ctg aac gac ata cag gag atg atc aaa       2377
Ala Asp Lys Leu Glu Glu Gly Leu Asn Asp Ile Gln Glu Met Ile Lys           
735                 740                 745                 750           

acg gag aag tcc tac cct gag cgt cgc ctg cgg ggc gtc ctg gag gag       2425
Thr Glu Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu           
                755                 760                 765               

ctg agc tgt ggc tgc tgc cgc ttc ctc tcc ctc gct gac aag gac cag       2473
Leu Ser Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp Lys Asp Gln           
            770                 775                 780                   

ggc cac tca tcc cgc acc agg ctt gac cgg gag cgc ctc aag tcc tgc       2521
Gly His Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys           
        785                 790                 795                       

atg agg gag ctg gaa aac atg ggg cag cag gcc agg atg ctg cgg gcc       2569
Met Arg Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met Leu Arg Ala           
    800                 805                 810                           

cag gtg aag cgg cac acg gtg cgg gac aag ctg agg ctg tgc cag aac       2617
Gln Val Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu Cys Gln Asn           
815                 820                 825                 830           

ttc ctg cag aag ctg cgc ttc ctg gcg gac gag ccc cag cac agc att       2665
Phe Leu Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile           
                835                 840                 845               

ccc gac atc ttc atc tgg atg atg agc aac aac aag cgt gtc gcc tat       2713
Pro Asp Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg Val Ala Tyr           
            850                 855                 860                   

gcc cgt gtg ccc tcc aag gac ctg ctc ttc tcc atc gtg gag gag gag       2761
Ala Arg Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu           
        865                 870                 875                       

act ggc aag gac tgc gcc aag gtc aag acg ctc ttc ctt aag ctg cca       2809
Thr Gly Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro           
    880                 885                 890                           

ggg aag cgg ggc ttc ggc tcg gca ggc tgg aca gtg cag gcc aag gtg       2857
Gly Lys Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Val           
895                 900                 905                 910           

gag ctg tac ctg tgg ctg ggc ctc agc aaa cag cgc aag gag ttc ctg       2905
Glu Leu Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Glu Phe Leu           
                915                 920                 925               

tgc ggc ctg ccc tgt ggc ttc cag gag gtc aag gca gcc cag ggc ctg       2953
Cys Gly Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala Gln Gly Leu           
            930                 935                 940                   

ggc ctg cat gcc ttc cca ccc gtc agc ctg gtc tac acc aag aag cag       3001
Gly Leu His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr Lys Lys Gln           
        945                 950                 955                       

gcg ttc cag ctc cga gcg cac atg tac cag gcc cgc agc ctc ttt gcc       3049
Ala Phe Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala           
    960                 965                 970                           

gcc gac agc agc gga ctc tca gac ccc ttt gcc cgc gtc ttc ttc atc       3097
Ala Asp Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile           
975                 980                 985                 990           

aat cag agt cag tgc aca gag gtg ctg aat  gag acc ctg tgt ccc  acc     3145
Asn Gln Ser Gln Cys Thr Glu Val Leu Asn  Glu Thr Leu Cys Pro  Thr         
                995                 1000                 1005             

tgg gac cag atg  ctg gtg ttc gac aac  ctg gag ctc tat ggt  gaa        3190
Trp Asp Gln Met  Leu Val Phe Asp Asn  Leu Glu Leu Tyr Gly  Glu            
            1010                 1015                 1020                

gct cat gag ctg  agg gac gat ccg ccc  atc att gtc att gaa  atc        3235
Ala His Glu Leu  Arg Asp Asp Pro Pro  Ile Ile Val Ile Glu  Ile            
            1025                 1030                 1035                

tat gac cag gat  tcc atg ggc aaa gct  gac ttc atg ggc cgg  acc        3280
Tyr Asp Gln Asp  Ser Met Gly Lys Ala  Asp Phe Met Gly Arg  Thr            
            1040                 1045                 1050                

ttc gcc aaa ccc  ctg gtg aag atg gca  gac gag gcg tac tgc  cca        3325
Phe Ala Lys Pro  Leu Val Lys Met Ala  Asp Glu Ala Tyr Cys  Pro            
            1055                 1060                 1065                

ccc cgc ttc cca  cct cag ctc gag tac  tac cag atc tac cgt  ggc        3370
Pro Arg Phe Pro  Pro Gln Leu Glu Tyr  Tyr Gln Ile Tyr Arg  Gly            
            1070                 1075                 1080                

aac gcc aca gct  gga gac ctg ctg gcg  gcc ttc gag ctg ctg  cag        3415
Asn Ala Thr Ala  Gly Asp Leu Leu Ala  Ala Phe Glu Leu Leu  Gln            
            1085                 1090                 1095                

att gga cca gca  ggg aag gct gac ctg  ccc ccc atc aat ggc  ccg        3460
Ile Gly Pro Ala  Gly Lys Ala Asp Leu  Pro Pro Ile Asn Gly  Pro            
            1100                 1105                 1110                

gtg gac gtg gac  cga ggt ccc atc atg  ccc gtg ccc atg ggc  atc        3505
Val Asp Val Asp  Arg Gly Pro Ile Met  Pro Val Pro Met Gly  Ile            
            1115                 1120                 1125                

cgg ccc gtg ctc  agc aag tac cga gtg  gag gtg ctg ttc tgg  ggc        3550
Arg Pro Val Leu  Ser Lys Tyr Arg Val  Glu Val Leu Phe Trp  Gly            
            1130                 1135                 1140                

cta cgg gac cta  aag cgg gtg aac ctg  gcc cag gtg gac cgg  cca        3595
Leu Arg Asp Leu  Lys Arg Val Asn Leu  Ala Gln Val Asp Arg  Pro            
            1145                 1150                 1155                

cgg gtg gac atc  gag tgt gca ggg aag  ggg gtg cag tcg tcc  ctg        3640
Arg Val Asp Ile  Glu Cys Ala Gly Lys  Gly Val Gln Ser Ser  Leu            
            1160                 1165                 1170                

atc cac aat tat  aag aag aac ccc aac  ttc aac acc ctc gtc  aag        3685
Ile His Asn Tyr  Lys Lys Asn Pro Asn  Phe Asn Thr Leu Val  Lys            
            1175                 1180                 1185                

tgg ttt gaa gtg  gac ctc cca gag aac  gag ctg ctg cac ccg  ccc        3730
Trp Phe Glu Val  Asp Leu Pro Glu Asn  Glu Leu Leu His Pro  Pro            
            1190                 1195                 1200                

ttg aac atc cgt  gtg gtg gac tgc cgg  gcc ttc ggt cgc tac  aca        3775
Leu Asn Ile Arg  Val Val Asp Cys Arg  Ala Phe Gly Arg Tyr  Thr            
            1205                 1210                 1215                

ctg gtg ggc tcc  cat gcc gtc agc tcc  ctg cga cgc ttc atc  tac        3820
Leu Val Gly Ser  His Ala Val Ser Ser  Leu Arg Arg Phe Ile  Tyr            
            1220                 1225                 1230                

cgg ccc cca gac  cgc tcg gcc ccc agc  tgg aac acc acg gtc  agg        3865
Arg Pro Pro Asp  Arg Ser Ala Pro Ser  Trp Asn Thr Thr Val  Arg            
            1235                 1240                 1245                

ctt ctc cgg cgc  tgc cgt gtg ctg tgc  aat ggg ggc tcc tcc  tct        3910
Leu Leu Arg Arg  Cys Arg Val Leu Cys  Asn Gly Gly Ser Ser  Ser            
            1250                 1255                 1260                

cac tcc aca ggg  gag gtt gtg gtg act  atg gag cca gag gta  ccc        3955
His Ser Thr Gly  Glu Val Val Val Thr  Met Glu Pro Glu Val  Pro            
            1265                 1270                 1275                

atc aag aaa ctg  gag acc atg gtg aag  ctg gac gcg act tct  gaa        4000
Ile Lys Lys Leu  Glu Thr Met Val Lys  Leu Asp Ala Thr Ser  Glu            
            1280                 1285                 1290                

gct gtt gtc aag  gtg gat gtg gct gag  gag gag aag gag aag  aag        4045
Ala Val Val Lys  Val Asp Val Ala Glu  Glu Glu Lys Glu Lys  Lys            
            1295                 1300                 1305                

aag aag aag aag  ggc act gcg gag gag  cca gag gag gag gag  cca        4090
Lys Lys Lys Lys  Gly Thr Ala Glu Glu  Pro Glu Glu Glu Glu  Pro            
            1310                 1315                 1320                

gac gag agc atg  ctg gac tgg tgg tcc  aag tac ttt gcc tcc  att        4135
Asp Glu Ser Met  Leu Asp Trp Trp Ser  Lys Tyr Phe Ala Ser  Ile            
            1325                 1330                 1335                

gac acc atg aag  gag caa ctt cga caa  caa gag ccc tct gga  att        4180
Asp Thr Met Lys  Glu Gln Leu Arg Gln  Gln Glu Pro Ser Gly  Ile            
            1340                 1345                 1350                

gac ttg gag gag  aag gag gaa gtg gac  aat acc gag ggc ctg  aag        4225
Asp Leu Glu Glu  Lys Glu Glu Val Asp  Asn Thr Glu Gly Leu  Lys            
            1355                 1360                 1365                

ggg tca atg aag  ggc aag gag aag gca  agg gct gcc aaa gag  gag        4270
Gly Ser Met Lys  Gly Lys Glu Lys Ala  Arg Ala Ala Lys Glu  Glu            
            1370                 1375                 1380                

aag aag aag aaa  act cag agc tct ggc  tct ggc cag ggg tcc  gag        4315
Lys Lys Lys Lys  Thr Gln Ser Ser Gly  Ser Gly Gln Gly Ser  Glu            
            1385                 1390                 1395                

gcc ccc gag aag  aag aaa ccc aag att  gat gag ctt aag gta  tac        4360
Ala Pro Glu Lys  Lys Lys Pro Lys Ile  Asp Glu Leu Lys Val  Tyr            
            1400                 1405                 1410                

ccc aaa gag ctg  gag tcc gag ttt gat  aac ttt gag gac tgg  ctg        4405
Pro Lys Glu Leu  Glu Ser Glu Phe Asp  Asn Phe Glu Asp Trp  Leu            
            1415                 1420                 1425                

cac act ttc aac  ttg ctt cgg ggc aag  acc ggg gat gat gag  gat        4450
His Thr Phe Asn  Leu Leu Arg Gly Lys  Thr Gly Asp Asp Glu  Asp            
            1430                 1435                 1440                

ggc tcc acc gag  gag gag cgc att gtg  gga cgc ttc aag ggc  tcc        4495
Gly Ser Thr Glu  Glu Glu Arg Ile Val  Gly Arg Phe Lys Gly  Ser            
            1445                 1450                 1455                

ctc tgc gtg tac  aaa gtg cca ctc cca  gag gac gtg tcc cgg  gaa        4540
Leu Cys Val Tyr  Lys Val Pro Leu Pro  Glu Asp Val Ser Arg  Glu            
            1460                 1465                 1470                

gcc ggc tac gac  tcc acc tac ggc atg  ttc cag ggc atc ccg  agc        4585
Ala Gly Tyr Asp  Ser Thr Tyr Gly Met  Phe Gln Gly Ile Pro  Ser            
            1475                 1480                 1485                

aat gac ccc atc  aat gtg ctg gtc cga  gtc tat gtg gtc cgg  gcc        4630
Asn Asp Pro Ile  Asn Val Leu Val Arg  Val Tyr Val Val Arg  Ala            
            1490                 1495                 1500                

acg gac ctg cac  cct gct gac atc aac  ggc aaa gct gac ccc  tac        4675
Thr Asp Leu His  Pro Ala Asp Ile Asn  Gly Lys Ala Asp Pro  Tyr            
            1505                 1510                 1515                

atc gcc atc cgg  cta ggc aag act gac  atc cgc gac aag gag  aac        4720
Ile Ala Ile Arg  Leu Gly Lys Thr Asp  Ile Arg Asp Lys Glu  Asn            
            1520                 1525                 1530                

tac atc tcc aag  cag ctc aac cct gtc  ttt ggg aag tcc ttt  gac        4765
Tyr Ile Ser Lys  Gln Leu Asn Pro Val  Phe Gly Lys Ser Phe  Asp            
            1535                 1540                 1545                

atc gag gcc tcc  ttc ccc atg gaa tcc  atg ctg acg gtg gct  gtg        4810
Ile Glu Ala Ser  Phe Pro Met Glu Ser  Met Leu Thr Val Ala  Val            
            1550                 1555                 1560                

tat gac tgg gac  ctg gtg ggc act gat  gac ctc att ggg gaa  acc        4855
Tyr Asp Trp Asp  Leu Val Gly Thr Asp  Asp Leu Ile Gly Glu  Thr            
            1565                 1570                 1575                

aag atc gac ctg  gag aac cgc ttc tac  agc aag cac cgc gcc  acc        4900
Lys Ile Asp Leu  Glu Asn Arg Phe Tyr  Ser Lys His Arg Ala  Thr            
            1580                 1585                 1590                

tgc ggc atc gcc  cag acc tac tcc aca  cat ggc tac aat atc  tgg        4945
Cys Gly Ile Ala  Gln Thr Tyr Ser Thr  His Gly Tyr Asn Ile  Trp            
            1595                 1600                 1605                

cgg gac ccc atg  aag ccc agc cag atc  ctg acc cgc ctc tgc  aaa        4990
Arg Asp Pro Met  Lys Pro Ser Gln Ile  Leu Thr Arg Leu Cys  Lys            
            1610                 1615                 1620                

gac ggc aaa gtg  gac ggc ccc cac ttt  ggg ccc cct ggg aga  gtg        5035
Asp Gly Lys Val  Asp Gly Pro His Phe  Gly Pro Pro Gly Arg  Val            
            1625                 1630                 1635                

aag gtg gcc aac  cgc gtc ttc act ggg  ccc tct gag att gag  gac        5080
Lys Val Ala Asn  Arg Val Phe Thr Gly  Pro Ser Glu Ile Glu  Asp            
            1640                 1645                 1650                

gag aac ggt cag  agg aag ccc aca gac  gag cat gtg gcg ctg  ttg        5125
Glu Asn Gly Gln  Arg Lys Pro Thr Asp  Glu His Val Ala Leu  Leu            
            1655                 1660                 1665                

gcc ctg agg cac  tgg gag gac atc ccc  cgc gca ggc tgc cgc  ctg        5170
Ala Leu Arg His  Trp Glu Asp Ile Pro  Arg Ala Gly Cys Arg  Leu            
            1670                 1675                 1680                

gtg cca gag cat  gtg gag acg agg ccg  ctg ctc aac ccc gac  aag        5215
Val Pro Glu His  Val Glu Thr Arg Pro  Leu Leu Asn Pro Asp  Lys            
            1685                 1690                 1695                

ccg ggc atc gag  cag ggc cgc ctg gag  ctg tgg gtg gac atg  ttc        5260
Pro Gly Ile Glu  Gln Gly Arg Leu Glu  Leu Trp Val Asp Met  Phe            
            1700                 1705                 1710                

ccc atg gac atg  cca gcc cct ggg acg  cct ctg gac atc tca  cct        5305
Pro Met Asp Met  Pro Ala Pro Gly Thr  Pro Leu Asp Ile Ser  Pro            
            1715                 1720                 1725                

cgg aag ccc aag  aag tac gag ctg cgg  gtc atc atc tgg aac  aca        5350
Arg Lys Pro Lys  Lys Tyr Glu Leu Arg  Val Ile Ile Trp Asn  Thr            
            1730                 1735                 1740                

gat gag gtg gtc  ttg gag gac gac gac  ttc ttc aca ggg gag  aag        5395
Asp Glu Val Val  Leu Glu Asp Asp Asp  Phe Phe Thr Gly Glu  Lys            
            1745                 1750                 1755                

tcc agt gac atc  ttc gtg agg ggg tgg  ctg aag ggc cag cag  gag        5440
Ser Ser Asp Ile  Phe Val Arg Gly Trp  Leu Lys Gly Gln Gln  Glu            
            1760                 1765                 1770                

gac aag cag gac  aca gac gtc cac tac  cac tcc ctc act ggc  gag        5485
Asp Lys Gln Asp  Thr Asp Val His Tyr  His Ser Leu Thr Gly  Glu            
            1775                 1780                 1785                

ggc aac ttc aac  tgg cgc tac ctg ttc  ccc ttc gac tac ctg  gcg        5530
Gly Asn Phe Asn  Trp Arg Tyr Leu Phe  Pro Phe Asp Tyr Leu  Ala            
            1790                 1795                 1800                

gcg gag gag aag  atc gtc atc tcc aag  aag gag tcc atg ttc  tcc        5575
Ala Glu Glu Lys  Ile Val Ile Ser Lys  Lys Glu Ser Met Phe  Ser            
            1805                 1810                 1815                

tgg gac gag acc  gag tac aag atc ccc  gcg cgg ctc acc ctg  cag        5620
Trp Asp Glu Thr  Glu Tyr Lys Ile Pro  Ala Arg Leu Thr Leu  Gln            
            1820                 1825                 1830                

atc tgg gat gcg  gac cac ttc tcc gct  gac gac ttc ctg ggg  gcc        5665
Ile Trp Asp Ala  Asp His Phe Ser Ala  Asp Asp Phe Leu Gly  Ala            
            1835                 1840                 1845                

atc gag ctg gac  ctg aac cgg ttc ccg  cgg ggc gca aag aca  gcc        5710
Ile Glu Leu Asp  Leu Asn Arg Phe Pro  Arg Gly Ala Lys Thr  Ala            
            1850                 1855                 1860                

aag cag tgc acc  atg gag atg gcc acc  ggg gag gtg gac gtg  ccc        5755
Lys Gln Cys Thr  Met Glu Met Ala Thr  Gly Glu Val Asp Val  Pro            
            1865                 1870                 1875                

ctc gtg tcc atc  ttc aag caa aag cgc  gtc aaa ggc tgg tgg  ccc        5800
Leu Val Ser Ile  Phe Lys Gln Lys Arg  Val Lys Gly Trp Trp  Pro            
            1880                 1885                 1890                

ctc ctg gcc cgc  aat gag aac gat gag  ttt gag ctc acg ggc  aag        5845
Leu Leu Ala Arg  Asn Glu Asn Asp Glu  Phe Glu Leu Thr Gly  Lys            
            1895                 1900                 1905                

gtg gag gct gag  ctg cat tta ctg aca  gca gag gag gca gag  aag        5890
Val Glu Ala Glu  Leu His Leu Leu Thr  Ala Glu Glu Ala Glu  Lys            
            1910                 1915                 1920                

aac cca gtg ggc  ctg gcc cgc aat gaa  cct gac ccc cta gag  aaa        5935
Asn Pro Val Gly  Leu Ala Arg Asn Glu  Pro Asp Pro Leu Glu  Lys            
            1925                 1930                 1935                

ccc aac cgg ccc  gac acg agc ttc atc  tgg ttc ctg aac cct  ctc        5980
Pro Asn Arg Pro  Asp Thr Ser Phe Ile  Trp Phe Leu Asn Pro  Leu            
            1940                 1945                 1950                

aag tcg gct cgc  tac ttc ttg tgg cac  acg tat cgc tgg ctg  ctc        6025
Lys Ser Ala Arg  Tyr Phe Leu Trp His  Thr Tyr Arg Trp Leu  Leu            
            1955                 1960                 1965                

ctc aaa ctg ttg  ctg ctc ctg ctg ctg  ctc ctc ctc ctc gcc  ctg        6070
Leu Lys Leu Leu  Leu Leu Leu Leu Leu  Leu Leu Leu Leu Ala  Leu            
            1970                 1975                 1980                

ttc ctc tac tct  gtg cct ggc tac ctg  gtc aag aaa atc ctc  ggg        6115
Phe Leu Tyr Ser  Val Pro Gly Tyr Leu  Val Lys Lys Ile Leu  Gly            
            1985                 1990                 1995                

gcc tga gcccagtggc ctcctggccg gcccgacacg gccttcgtct ggttcctcaa        6171
Ala                                                                       
                                                                          

ccctctcaag tccatcaagt acctcatctg cacccggtac aagtggctca tcatcaagat     6231

cgtgctggcg ctgttggggc tgctcatgtt ggggctcttc ctctacagcc tccctggcta     6291

catggtcaaa aagctccttg gggcatgaag gccgccagct cccgccagcc gctccccagc     6351

cctgccgcat ttcctttcag tggcttggac tctttcccat ctcccctggg gagcctgagg     6411

agcccagcgt ccactcttca tgccttgggc cgagcctgcc tcctgcttgc gggggccgcc     6471

tgtcctcact gccccaggct gcggcttgcc cagtcccgcc cctctgaccc ctgcctgtgg     6531

gctggggagc cttggatggg gtggggacct ggaatgggtc tctcttgccc cacctggctg     6591

aggcgccacc cttcttcagg cccaggctcc agaggaagac tcctgaaacc ctccccaggt     6651

cttccaagta caggattgaa gctttagtga aattaaccaa ggaccatggg tcagtgccca     6711

gggctttaaa aagaatgaac gagcaaaagg tatccccgcc gtgacccctg cagatagcac     6771

cggtctttga tccgcagcag gggccagacc ctgcccacaa gtcccagcgc ggctgcttct     6831

gccactgctg ggctccactt ggctcctctc acttcccagg gggtcgcctg tcctgcctgt     6891

gggtttccat ggcttcccag agctccctct gccccagcca gcgcctccag gcccagctga     6951

ggagctgtga gaagcagcag aggggactcc ccatcccggg cacaccctgt cctcccaccc     7011

ctgccccctt gcccttccag ccctttcagc tgcagctggg agctggcccg tcaagtgctg     7071

cccctgcctg tgtctgggtt tctgttggct gtttttcttt tcttgagtgg tgatttttct     7131

ctaaataaaa gaagtcaagc actgaaaaaa aaaaaaaaaa                           7171


<210>  268
<211>  1997
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Ala Leu Leu Ile His Leu Lys Thr Val Ser Glu Leu Arg Gly Arg 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Asp Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Met Leu Glu Ile 
    50                  55                  60                  


Gln Val Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Arg Met Val Leu Gln Lys Val Val Glu Glu Ser His Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Ile Asp Asp Asn Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Cys Val Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Ser Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Glu Lys 
    130                 135                 140                 


Asp Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Ser 
145                 150                 155                 160 


Arg Pro Pro Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe 
                165                 170                 175     


Ser Ala Met Lys Leu Gly Lys Asn Arg Ser His Lys Glu Glu Pro Gln 
            180                 185                 190         


Arg Pro Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu 
        195                 200                 205             


Ala Ile Arg Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala 
    210                 215                 220                 


Ser Val Thr Ala Leu Thr Thr Asn Val Ser Asn Lys Arg Ser Lys Pro 
225                 230                 235                 240 


Asp Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val 
                245                 250                 255     


Ser Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp 
            260                 265                 270         


Pro Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met 
        275                 280                 285             


Lys Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp 
    290                 295                 300                 


Phe His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser 
305                 310                 315                 320 


Val Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser 
                325                 330                 335     


Phe Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe 
            340                 345                 350         


His His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ser Gly 
        355                 360                 365             


Leu Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp 
    370                 375                 380                 


Asn Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile 
385                 390                 395                 400 


Glu Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp 
                405                 410                 415     


Ala Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met 
            420                 425                 430         


Asn Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn 
        435                 440                 445             


Lys Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys 
    450                 455                 460                 


Gly Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu 
465                 470                 475                 480 


Gln Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys 
                485                 490                 495     


Val Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr 
            500                 505                 510         


His Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe 
        515                 520                 525             


Leu Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg 
    530                 535                 540                 


Asn Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly 
545                 550                 555                 560 


Glu Gly Val Ser Phe Arg Ala Arg Leu Leu Leu Gly Leu Ala Val Glu 
                565                 570                 575     


Ile Val Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln 
            580                 585                 590         


Val Glu Gln Ala Thr Pro Ile Ser Glu Ser Cys Ala Gly Lys Met Glu 
        595                 600                 605             


Glu Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg 
    610                 615                 620                 


Arg Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr 
625                 630                 635                 640 


Gly Asn Glu Val Asp Gly Leu Ser Arg Pro Gln Arg Pro Arg Pro Arg 
                645                 650                 655     


Lys Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ala Ser 
            660                 665                 670         


Asp Asp Glu Ala Gly Asp Ala Gly Asp Leu Ala Ser Val Ser Ser Thr 
        675                 680                 685             


Pro Pro Met Arg Pro Gln Val Thr Asp Arg Asn Tyr Phe His Leu Pro 
    690                 695                 700                 


Tyr Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp 
705                 710                 715                 720 


Gln Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp 
                725                 730                 735     


Lys Leu Glu Glu Gly Leu Asn Asp Ile Gln Glu Met Ile Lys Thr Glu 
            740                 745                 750         


Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser 
        755                 760                 765             


Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp Lys Asp Gln Gly His 
    770                 775                 780                 


Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg 
785                 790                 795                 800 


Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met Leu Arg Ala Gln Val 
                805                 810                 815     


Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu Cys Gln Asn Phe Leu 
            820                 825                 830         


Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp 
        835                 840                 845             


Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg Val Ala Tyr Ala Arg 
    850                 855                 860                 


Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Thr Gly 
865                 870                 875                 880 


Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys 
                885                 890                 895     


Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Val Glu Leu 
            900                 905                 910         


Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Glu Phe Leu Cys Gly 
        915                 920                 925             


Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala Gln Gly Leu Gly Leu 
    930                 935                 940                 


His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe 
945                 950                 955                 960 


Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp 
                965                 970                 975     


Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln 
            980                 985                 990         


Ser Gln Cys Thr Glu Val Leu Asn  Glu Thr Leu Cys Pro  Thr Trp Asp 
        995                 1000                 1005             


Gln Met  Leu Val Phe Asp Asn  Leu Glu Leu Tyr Gly  Glu Ala His 
    1010                 1015                 1020             


Glu Leu  Arg Asp Asp Pro Pro  Ile Ile Val Ile Glu  Ile Tyr Asp 
    1025                 1030                 1035             


Gln Asp  Ser Met Gly Lys Ala  Asp Phe Met Gly Arg  Thr Phe Ala 
    1040                 1045                 1050             


Lys Pro  Leu Val Lys Met Ala  Asp Glu Ala Tyr Cys  Pro Pro Arg 
    1055                 1060                 1065             


Phe Pro  Pro Gln Leu Glu Tyr  Tyr Gln Ile Tyr Arg  Gly Asn Ala 
    1070                 1075                 1080             


Thr Ala  Gly Asp Leu Leu Ala  Ala Phe Glu Leu Leu  Gln Ile Gly 
    1085                 1090                 1095             


Pro Ala  Gly Lys Ala Asp Leu  Pro Pro Ile Asn Gly  Pro Val Asp 
    1100                 1105                 1110             


Val Asp  Arg Gly Pro Ile Met  Pro Val Pro Met Gly  Ile Arg Pro 
    1115                 1120                 1125             


Val Leu  Ser Lys Tyr Arg Val  Glu Val Leu Phe Trp  Gly Leu Arg 
    1130                 1135                 1140             


Asp Leu  Lys Arg Val Asn Leu  Ala Gln Val Asp Arg  Pro Arg Val 
    1145                 1150                 1155             


Asp Ile  Glu Cys Ala Gly Lys  Gly Val Gln Ser Ser  Leu Ile His 
    1160                 1165                 1170             


Asn Tyr  Lys Lys Asn Pro Asn  Phe Asn Thr Leu Val  Lys Trp Phe 
    1175                 1180                 1185             


Glu Val  Asp Leu Pro Glu Asn  Glu Leu Leu His Pro  Pro Leu Asn 
    1190                 1195                 1200             


Ile Arg  Val Val Asp Cys Arg  Ala Phe Gly Arg Tyr  Thr Leu Val 
    1205                 1210                 1215             


Gly Ser  His Ala Val Ser Ser  Leu Arg Arg Phe Ile  Tyr Arg Pro 
    1220                 1225                 1230             


Pro Asp  Arg Ser Ala Pro Ser  Trp Asn Thr Thr Val  Arg Leu Leu 
    1235                 1240                 1245             


Arg Arg  Cys Arg Val Leu Cys  Asn Gly Gly Ser Ser  Ser His Ser 
    1250                 1255                 1260             


Thr Gly  Glu Val Val Val Thr  Met Glu Pro Glu Val  Pro Ile Lys 
    1265                 1270                 1275             


Lys Leu  Glu Thr Met Val Lys  Leu Asp Ala Thr Ser  Glu Ala Val 
    1280                 1285                 1290             


Val Lys  Val Asp Val Ala Glu  Glu Glu Lys Glu Lys  Lys Lys Lys 
    1295                 1300                 1305             


Lys Lys  Gly Thr Ala Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu 
    1310                 1315                 1320             


Ser Met  Leu Asp Trp Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr 
    1325                 1330                 1335             


Met Lys  Glu Gln Leu Arg Gln  Gln Glu Pro Ser Gly  Ile Asp Leu 
    1340                 1345                 1350             


Glu Glu  Lys Glu Glu Val Asp  Asn Thr Glu Gly Leu  Lys Gly Ser 
    1355                 1360                 1365             


Met Lys  Gly Lys Glu Lys Ala  Arg Ala Ala Lys Glu  Glu Lys Lys 
    1370                 1375                 1380             


Lys Lys  Thr Gln Ser Ser Gly  Ser Gly Gln Gly Ser  Glu Ala Pro 
    1385                 1390                 1395             


Glu Lys  Lys Lys Pro Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys 
    1400                 1405                 1410             


Glu Leu  Glu Ser Glu Phe Asp  Asn Phe Glu Asp Trp  Leu His Thr 
    1415                 1420                 1425             


Phe Asn  Leu Leu Arg Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser 
    1430                 1435                 1440             


Thr Glu  Glu Glu Arg Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys 
    1445                 1450                 1455             


Val Tyr  Lys Val Pro Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly 
    1460                 1465                 1470             


Tyr Asp  Ser Thr Tyr Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp 
    1475                 1480                 1485             


Pro Ile  Asn Val Leu Val Arg  Val Tyr Val Val Arg  Ala Thr Asp 
    1490                 1495                 1500             


Leu His  Pro Ala Asp Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala 
    1505                 1510                 1515             


Ile Arg  Leu Gly Lys Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile 
    1520                 1525                 1530             


Ser Lys  Gln Leu Asn Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu 
    1535                 1540                 1545             


Ala Ser  Phe Pro Met Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp 
    1550                 1555                 1560             


Trp Asp  Leu Val Gly Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile 
    1565                 1570                 1575             


Asp Leu  Glu Asn Arg Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly 
    1580                 1585                 1590             


Ile Ala  Gln Thr Tyr Ser Thr  His Gly Tyr Asn Ile  Trp Arg Asp 
    1595                 1600                 1605             


Pro Met  Lys Pro Ser Gln Ile  Leu Thr Arg Leu Cys  Lys Asp Gly 
    1610                 1615                 1620             


Lys Val  Asp Gly Pro His Phe  Gly Pro Pro Gly Arg  Val Lys Val 
    1625                 1630                 1635             


Ala Asn  Arg Val Phe Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn 
    1640                 1645                 1650             


Gly Gln  Arg Lys Pro Thr Asp  Glu His Val Ala Leu  Leu Ala Leu 
    1655                 1660                 1665             


Arg His  Trp Glu Asp Ile Pro  Arg Ala Gly Cys Arg  Leu Val Pro 
    1670                 1675                 1680             


Glu His  Val Glu Thr Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly 
    1685                 1690                 1695             


Ile Glu  Gln Gly Arg Leu Glu  Leu Trp Val Asp Met  Phe Pro Met 
    1700                 1705                 1710             


Asp Met  Pro Ala Pro Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys 
    1715                 1720                 1725             


Pro Lys  Lys Tyr Glu Leu Arg  Val Ile Ile Trp Asn  Thr Asp Glu 
    1730                 1735                 1740             


Val Val  Leu Glu Asp Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser 
    1745                 1750                 1755             


Asp Ile  Phe Val Arg Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys 
    1760                 1765                 1770             


Gln Asp  Thr Asp Val His Tyr  His Ser Leu Thr Gly  Glu Gly Asn 
    1775                 1780                 1785             


Phe Asn  Trp Arg Tyr Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu 
    1790                 1795                 1800             


Glu Lys  Ile Val Ile Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp 
    1805                 1810                 1815             


Glu Thr  Glu Tyr Lys Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp 
    1820                 1825                 1830             


Asp Ala  Asp His Phe Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu 
    1835                 1840                 1845             


Leu Asp  Leu Asn Arg Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln 
    1850                 1855                 1860             


Cys Thr  Met Glu Met Ala Thr  Gly Glu Val Asp Val  Pro Leu Val 
    1865                 1870                 1875             


Ser Ile  Phe Lys Gln Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu 
    1880                 1885                 1890             


Ala Arg  Asn Glu Asn Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu 
    1895                 1900                 1905             


Ala Glu  Leu His Leu Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro 
    1910                 1915                 1920             


Val Gly  Leu Ala Arg Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn 
    1925                 1930                 1935             


Arg Pro  Asp Thr Ser Phe Ile  Trp Phe Leu Asn Pro  Leu Lys Ser 
    1940                 1945                 1950             


Ala Arg  Tyr Phe Leu Trp His  Thr Tyr Arg Trp Leu  Leu Leu Lys 
    1955                 1960                 1965             


Leu Leu  Leu Leu Leu Leu Leu  Leu Leu Leu Leu Ala  Leu Phe Leu 
    1970                 1975                 1980             


Tyr Ser  Val Pro Gly Tyr Leu  Val Lys Lys Ile Leu  Gly Ala 
    1985                 1990                 1995         


<210>  269
<211>  2891
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (109)..(1239)

<400>  269
gctccctcgc cgccctgaac cggcggctag actgcgcatg cgtgtcagtg gcgctagcgg       60

cggacccggc tgggcagttc cttccccaga aggagagatt cctctgcc atg gag tcc       117
                                                     Met Glu Ser          
                                                     1                    

tac gat gtg atc gcc aac cag cct gtc gtg atc gac aac gga tcc ggt        165
Tyr Asp Val Ile Ala Asn Gln Pro Val Val Ile Asp Asn Gly Ser Gly           
    5                   10                  15                            

gtg att aaa gct ggt ttt gct ggt gat cag atc ccc aaa tac tgc ttt        213
Val Ile Lys Ala Gly Phe Ala Gly Asp Gln Ile Pro Lys Tyr Cys Phe           
20                  25                  30                  35            

cca aac tat gtg ggc cga ccc aag cac gtt cgt gtc atg gca gga gcc        261
Pro Asn Tyr Val Gly Arg Pro Lys His Val Arg Val Met Ala Gly Ala           
                40                  45                  50                

ctt gaa ggc gac atc ttc att ggc ccc aaa gct gag gag cac cga ggg        309
Leu Glu Gly Asp Ile Phe Ile Gly Pro Lys Ala Glu Glu His Arg Gly           
            55                  60                  65                    

ctg ctt tca atc cgc tat ccc atg gag cat ggc atc gtc aag gat tgg        357
Leu Leu Ser Ile Arg Tyr Pro Met Glu His Gly Ile Val Lys Asp Trp           
        70                  75                  80                        

aac gac atg gaa cgc att tgg caa tat gtc tat tct aag gac cag ctg        405
Asn Asp Met Glu Arg Ile Trp Gln Tyr Val Tyr Ser Lys Asp Gln Leu           
    85                  90                  95                            

cag act ttc tca gag gag cat cct gtg ctc ctg act gag gcg cct tta        453
Gln Thr Phe Ser Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu           
100                 105                 110                 115           

aac cca cga aaa aac cgg gaa cga gct gcc gaa gtt ttc ttc gag acc        501
Asn Pro Arg Lys Asn Arg Glu Arg Ala Ala Glu Val Phe Phe Glu Thr           
                120                 125                 130               

ttc aat gtg ccc gct ctt ttc atc tcc atg caa gct gta ctc agc ctt        549
Phe Asn Val Pro Ala Leu Phe Ile Ser Met Gln Ala Val Leu Ser Leu           
            135                 140                 145                   

tac gct aca ggc agg acc aca ggg gtg gtg ctg gat tct ggg gat gga        597
Tyr Ala Thr Gly Arg Thr Thr Gly Val Val Leu Asp Ser Gly Asp Gly           
        150                 155                 160                       

gtc acc cat gct gtg ccc atc tat gag ggc ttt gcc atg ccc cac tcc        645
Val Thr His Ala Val Pro Ile Tyr Glu Gly Phe Ala Met Pro His Ser           
    165                 170                 175                           

atc atg cgc atc gac atc gcg ggc cgg gac gtc tct cgc ttc ctg cgc        693
Ile Met Arg Ile Asp Ile Ala Gly Arg Asp Val Ser Arg Phe Leu Arg           
180                 185                 190                 195           

ctc tac ctg cgt aag gag ggc tac gac ttc cac tca tcc tct gag ttt        741
Leu Tyr Leu Arg Lys Glu Gly Tyr Asp Phe His Ser Ser Ser Glu Phe           
                200                 205                 210               

gag att gtc aag gcc ata aaa gaa aga gcc tgt tac cta tcc ata aac        789
Glu Ile Val Lys Ala Ile Lys Glu Arg Ala Cys Tyr Leu Ser Ile Asn           
            215                 220                 225                   

ccc caa aag gat gag acg cta gag aca gag aaa gct cag tac tac ctg        837
Pro Gln Lys Asp Glu Thr Leu Glu Thr Glu Lys Ala Gln Tyr Tyr Leu           
        230                 235                 240                       

cct gat ggc agc acc att gag att ggt cct tcc cga ttc cgg gcc cct        885
Pro Asp Gly Ser Thr Ile Glu Ile Gly Pro Ser Arg Phe Arg Ala Pro           
    245                 250                 255                           

gag ttg ctc ttc agg cca gat ttg att gga gag gag agt gaa ggc atc        933
Glu Leu Leu Phe Arg Pro Asp Leu Ile Gly Glu Glu Ser Glu Gly Ile           
260                 265                 270                 275           

cac gag gtc ctg gtg ttc gcc att cag aag tca gac atg gac ctg cgg        981
His Glu Val Leu Val Phe Ala Ile Gln Lys Ser Asp Met Asp Leu Arg           
                280                 285                 290               

cgc acg ctt ttc tct aac att gtc ctc tca gga ggc tct acc ctg ttc       1029
Arg Thr Leu Phe Ser Asn Ile Val Leu Ser Gly Gly Ser Thr Leu Phe           
            295                 300                 305                   

aaa ggt ttt ggt gac agg ctc ctg agt gaa gtg aag aaa cta gct cca       1077
Lys Gly Phe Gly Asp Arg Leu Leu Ser Glu Val Lys Lys Leu Ala Pro           
        310                 315                 320                       

aaa gat gtg aag atc agg ata tct gca cct cag gag aga ctg tat tcc       1125
Lys Asp Val Lys Ile Arg Ile Ser Ala Pro Gln Glu Arg Leu Tyr Ser           
    325                 330                 335                           

acg tgg att ggg ggc tcc atc ctt gcc tcc ctg gac acc ttt aag aag       1173
Thr Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Asp Thr Phe Lys Lys           
340                 345                 350                 355           

atg tgg gtc tcc aaa aag gaa tat gag gaa gac ggt gcc cga tcc atc       1221
Met Trp Val Ser Lys Lys Glu Tyr Glu Glu Asp Gly Ala Arg Ser Ile           
                360                 365                 370               

cac aga aaa acc ttc taa tgtcgggaca tcatcttcac ctctctctga              1269
His Arg Lys Thr Phe                                                       
            375                                                           

agttaactcc actttaaaac tcgctttctt gagtcggagt gtttgcgagg aactgcctgt     1329

gtgtgagtgc gtgtgtggat atgagtgtgt gtgcacatgc gagtgccgtg tggccctggg     1389

accctgggcc cagaaaggac gatgaactac ctgcagtggt gatggcctga ggcctggggt     1449

tgaccactaa ctggctcctg acagggaaga gcgctggcag aggctgtgct ccctcctcag     1509

gtggcctctg gctggctgtg ggggactccg tttactacca cagggagaca gagggaggta     1569

agccatcccc cgggagacct tgctgctgac catcctaggc tgggctggcc ccaccctcac     1629

ccccaccccc agggtgccct gaggccccag gcagctgctg cctccactat cgatgcctcc     1689

tgactgcaca ctgaggactg ggactggggt tgagttctgt ctggttttgt tgccattttg     1749

gtttgggagg ctggaaaagc accccaagag ctattacaga gactggagtc aggagagagc     1809

aggaggccct catgttcacc agggaacagg accacaccgg ccactggagg agggcaggag     1869

cagtcctcac tctgaatggc tgcagagtta atgttcccag cccagtcccc tttcgggggc     1929

cttgggagag tttaaggcac ctgctggttc caggacctcg ctttccatct gttcttgttg     1989

caatgccatc ttcaaaccgt tttatttatt gaagtgtttg ttcagttagg ggctggagag     2049

agggagcttg ctgcctcctg ccttgctaca ctaatgttta cagcacctaa gcttagcctc     2109

cagggcccca cctctcccag ctgatggtga gctgacagtg tccacaggtt ccaggaccat     2169

ttgagattgg aagctacact caaagacact cccaccaggc tctttctccc ttttcctctt     2229

gctcactgcc ctggaatcaa caggctggtt gctggttaga ttttctgaaa caggaggtaa     2289

aatttttctt tggcagaggc ccctaagcaa gggaggggtg ttggagagcc agtgccctta     2349

agactggaga aagctgcaat ttaccaagtt gccttttgcc actgtagctg accaggggac     2409

taggttgtag aggtgggaag gccccctctg ggctgatctt gtgccattct tgaccttgga     2469

cctgcttggt taaggaggga gtgggccaga ccagagtgcc aggagctaat ggagccaggc     2529

ctgactccta ggagtggtcc aaaggccttc agcctagatg gtgcaaagct ggggccagcc     2589

tgtcttcacc ggcaccctca cctgtgacac caagacccac cccaatccca gacttcacac     2649

agtattctcc cccacgccgt cctatgacca aaggcccctg ccaggtgtgg gccacagcag     2709

caggtatgtg tgaaagcaac gtagcgcccc gcggactgca gtgcgcttaa ccaactcacc     2769

tcccttctct tagcccaagc ctgtccctcg cacagcctcg cacaaaccac attgcctggt     2829

ggggcccagt gtactgaaat aaagtcgttc cgatagacac gtcaaaaaaa aaaaaaaaaa     2889

aa                                                                    2891


<210>  270
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  270

Met Glu Ser Tyr Asp Val Ile Ala Asn Gln Pro Val Val Ile Asp Asn 
1               5                   10                  15      


Gly Ser Gly Val Ile Lys Ala Gly Phe Ala Gly Asp Gln Ile Pro Lys 
            20                  25                  30          


Tyr Cys Phe Pro Asn Tyr Val Gly Arg Pro Lys His Val Arg Val Met 
        35                  40                  45              


Ala Gly Ala Leu Glu Gly Asp Ile Phe Ile Gly Pro Lys Ala Glu Glu 
    50                  55                  60                  


His Arg Gly Leu Leu Ser Ile Arg Tyr Pro Met Glu His Gly Ile Val 
65                  70                  75                  80  


Lys Asp Trp Asn Asp Met Glu Arg Ile Trp Gln Tyr Val Tyr Ser Lys 
                85                  90                  95      


Asp Gln Leu Gln Thr Phe Ser Glu Glu His Pro Val Leu Leu Thr Glu 
            100                 105                 110         


Ala Pro Leu Asn Pro Arg Lys Asn Arg Glu Arg Ala Ala Glu Val Phe 
        115                 120                 125             


Phe Glu Thr Phe Asn Val Pro Ala Leu Phe Ile Ser Met Gln Ala Val 
    130                 135                 140                 


Leu Ser Leu Tyr Ala Thr Gly Arg Thr Thr Gly Val Val Leu Asp Ser 
145                 150                 155                 160 


Gly Asp Gly Val Thr His Ala Val Pro Ile Tyr Glu Gly Phe Ala Met 
                165                 170                 175     


Pro His Ser Ile Met Arg Ile Asp Ile Ala Gly Arg Asp Val Ser Arg 
            180                 185                 190         


Phe Leu Arg Leu Tyr Leu Arg Lys Glu Gly Tyr Asp Phe His Ser Ser 
        195                 200                 205             


Ser Glu Phe Glu Ile Val Lys Ala Ile Lys Glu Arg Ala Cys Tyr Leu 
    210                 215                 220                 


Ser Ile Asn Pro Gln Lys Asp Glu Thr Leu Glu Thr Glu Lys Ala Gln 
225                 230                 235                 240 


Tyr Tyr Leu Pro Asp Gly Ser Thr Ile Glu Ile Gly Pro Ser Arg Phe 
                245                 250                 255     


Arg Ala Pro Glu Leu Leu Phe Arg Pro Asp Leu Ile Gly Glu Glu Ser 
            260                 265                 270         


Glu Gly Ile His Glu Val Leu Val Phe Ala Ile Gln Lys Ser Asp Met 
        275                 280                 285             


Asp Leu Arg Arg Thr Leu Phe Ser Asn Ile Val Leu Ser Gly Gly Ser 
    290                 295                 300                 


Thr Leu Phe Lys Gly Phe Gly Asp Arg Leu Leu Ser Glu Val Lys Lys 
305                 310                 315                 320 


Leu Ala Pro Lys Asp Val Lys Ile Arg Ile Ser Ala Pro Gln Glu Arg 
                325                 330                 335     


Leu Tyr Ser Thr Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Asp Thr 
            340                 345                 350         


Phe Lys Lys Met Trp Val Ser Lys Lys Glu Tyr Glu Glu Asp Gly Ala 
        355                 360                 365             


Arg Ser Ile His Arg Lys Thr Phe 
    370                 375     


<210>  271
<211>  1671
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (70)..(519)

<400>  271
ccggtctttc cagccccgag agggacctgg ttcctctgcc caggcttctg tcactctgtc       60

acctacgct atg ccc tgc tgt agt cac agg agg tgt aga gag gac ccc ggg      111
          Met Pro Cys Cys Ser His Arg Arg Cys Arg Glu Asp Pro Gly         
          1               5                   10                          

aca tct gaa agc cag gaa atg gag gag tgg gct ttg ctg gat att tcc        159
Thr Ser Glu Ser Gln Glu Met Glu Glu Trp Ala Leu Leu Asp Ile Ser           
15                  20                  25                  30            

cag agg aaa ctc tac aag gaa gtg atg ctg gaa act ttc agg aac ctg        207
Gln Arg Lys Leu Tyr Lys Glu Val Met Leu Glu Thr Phe Arg Asn Leu           
                35                  40                  45                

acc tct gta gga aaa agt tgg aaa gac cag aac att gaa tat gag tac        255
Thr Ser Val Gly Lys Ser Trp Lys Asp Gln Asn Ile Glu Tyr Glu Tyr           
            50                  55                  60                    

caa aac ccc agg aga aac ttc agg agt ctc ata gaa aag aaa gtc aat        303
Gln Asn Pro Arg Arg Asn Phe Arg Ser Leu Ile Glu Lys Lys Val Asn           
        65                  70                  75                        

gaa att aaa gat gac agt cat tgt gga gaa act ttt acc cag gtt cca        351
Glu Ile Lys Asp Asp Ser His Cys Gly Glu Thr Phe Thr Gln Val Pro           
    80                  85                  90                            

gat gac agg ctg aac ttc cag gag aag aaa gct tct cct gaa ata aaa        399
Asp Asp Arg Leu Asn Phe Gln Glu Lys Lys Ala Ser Pro Glu Ile Lys           
95                  100                 105                 110           

tca tgt gac agc ttt gtg tgt gga gaa gtt ggc cta ggt aac tca tct        447
Ser Cys Asp Ser Phe Val Cys Gly Glu Val Gly Leu Gly Asn Ser Ser           
                115                 120                 125               

ttt aat atg aac atc aga ggt gac att gga cac aag gcc tat gag tat        495
Phe Asn Met Asn Ile Arg Gly Asp Ile Gly His Lys Ala Tyr Glu Tyr           
            130                 135                 140                   

cag gaa tat gga ccg aag cca taa aaaaatctca ctctgtcacc caggctggag       549
Gln Glu Tyr Gly Pro Lys Pro                                               
        145                                                               

tgcagtggca tgatctcagg tcgctgcaac ctctgcctcc agggttcaag caactctcct      609

gcttcagcct cctgagtagc tgggactaca ggcatgcacc accacgccag gctaattttt      669

tgtatttttt agtagagaca gggtttcacc atattggcca ggctggtctt gaactccaga      729

cctcatgatt cgcctgcctc ggcctcccaa aatgctggga ttacagatat gagccatcat      789

gcccagccgc aaccctaatt tttcattcag tcataatacc aacagttatc tcatgtacct      849

ctgagtgcct tcttcccaaa agccagcagt accatacctg ctgtcagcaa gtgtgtaata      909

taccatagtg ataaatatga ccaaaagcca taaatgactg tgagatgtat gagaatgaca      969

cgtcacatta gtaagaagag aaaaattttg gccatgttta tgatttgaaa tatgttttcc     1029

tctatcacat ttagaaatat agttacaaaa tgcccttagt tttatcctga ttcatcatgg     1089

tcactgagga gcatcgtctc atatgcctgg tatgtgacat gtgtctcttc aacagtaaaa     1149

gacttggcat tggctgggca tggtggctca cgcctgtaat cccagcactt tgggaggccg     1209

aggtcaggag ttagagacca ttctgaccaa tatgatcaaa ccccgtctct actaaaaata     1269

caaaaattag cggggtgtgg tggcatgctc ctgtaatcct agctattcag gaggctgacg     1329

caggagactt gcttgaatat aggaggcaga cgttgcagtg agccgaggtc acaccattca     1389

ctccagcctg ggcaacaaga gcgaaactcc gtttcaaaaa aaaaaaaaat gacttggact     1449

tgtggtgagg ggaggtcatc tgtagactcc tggacctgtt tttgccttac ttattctcta     1509

aagactgaaa tatttcctaa aatgtatggg cactgtttac cagaaagtac cttagttaaa     1569

acataaaatc atttatgcct tataaagcta tattttttca attgctttac tgagtcatag     1629

gaggctaata aatttgtgta aattgtctaa aaaaaaaaaa aa                        1671


<210>  272
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  272

Met Pro Cys Cys Ser His Arg Arg Cys Arg Glu Asp Pro Gly Thr Ser 
1               5                   10                  15      


Glu Ser Gln Glu Met Glu Glu Trp Ala Leu Leu Asp Ile Ser Gln Arg 
            20                  25                  30          


Lys Leu Tyr Lys Glu Val Met Leu Glu Thr Phe Arg Asn Leu Thr Ser 
        35                  40                  45              


Val Gly Lys Ser Trp Lys Asp Gln Asn Ile Glu Tyr Glu Tyr Gln Asn 
    50                  55                  60                  


Pro Arg Arg Asn Phe Arg Ser Leu Ile Glu Lys Lys Val Asn Glu Ile 
65                  70                  75                  80  


Lys Asp Asp Ser His Cys Gly Glu Thr Phe Thr Gln Val Pro Asp Asp 
                85                  90                  95      


Arg Leu Asn Phe Gln Glu Lys Lys Ala Ser Pro Glu Ile Lys Ser Cys 
            100                 105                 110         


Asp Ser Phe Val Cys Gly Glu Val Gly Leu Gly Asn Ser Ser Phe Asn 
        115                 120                 125             


Met Asn Ile Arg Gly Asp Ile Gly His Lys Ala Tyr Glu Tyr Gln Glu 
    130                 135                 140                 


Tyr Gly Pro Lys Pro 
145                 


<210>  273
<211>  6335
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (147)..(5132)

<400>  273
gcccaacatg gctggagcgc ggcggaggtg agccggccgc ccgcccgcag acgccccagc       60

ctactgcgcc cgagtcccgc ggccccagtg gcgcctcagc tctgcggtgc cgaggcccaa      120

cggctcgatc gctgcccgcc gccagc atg ttg ggc gcc ccg gac gag agc tcc       173
                             Met Leu Gly Ala Pro Asp Glu Ser Ser          
                             1               5                            

gtg cgg gtg gct gtc aga ata aga cca cag ctt gcc aaa gag aag att        221
Val Arg Val Ala Val Arg Ile Arg Pro Gln Leu Ala Lys Glu Lys Ile           
10                  15                  20                  25            

gaa gga tgc cat att tgt aca tct gtc aca cca gga gag cct cag gtc        269
Glu Gly Cys His Ile Cys Thr Ser Val Thr Pro Gly Glu Pro Gln Val           
                30                  35                  40                

ttc cta ggg aaa gat aag gct ttt act ttt gac tat gta ttt gac att        317
Phe Leu Gly Lys Asp Lys Ala Phe Thr Phe Asp Tyr Val Phe Asp Ile           
            45                  50                  55                    

gac tcc cag caa gag cag atc tac att caa tgt ata gaa aaa cta att        365
Asp Ser Gln Gln Glu Gln Ile Tyr Ile Gln Cys Ile Glu Lys Leu Ile           
        60                  65                  70                        

gaa ggt tgc ttt gaa gga tac aat gct aca gtt ttt gct tat gga caa        413
Glu Gly Cys Phe Glu Gly Tyr Asn Ala Thr Val Phe Ala Tyr Gly Gln           
    75                  80                  85                            

act gga gct ggt aaa aca tac aca atg gga aca gga ttt gat gtt aac        461
Thr Gly Ala Gly Lys Thr Tyr Thr Met Gly Thr Gly Phe Asp Val Asn           
90                  95                  100                 105           

att gtt gag gaa gaa ctg ggt att att tct cga gct gtt aaa cac ctt        509
Ile Val Glu Glu Glu Leu Gly Ile Ile Ser Arg Ala Val Lys His Leu           
                110                 115                 120               

ttt aag agt att gaa gaa aaa aaa cac ata gca att aaa aat ggg ctt        557
Phe Lys Ser Ile Glu Glu Lys Lys His Ile Ala Ile Lys Asn Gly Leu           
            125                 130                 135                   

cct gct cca gat ttt aaa gtg aat gcc caa ttc tta gag ctc tat aat        605
Pro Ala Pro Asp Phe Lys Val Asn Ala Gln Phe Leu Glu Leu Tyr Asn           
        140                 145                 150                       

gaa gag gtc ctt gac tta ttt gat acc act cgt gat att gat gca aaa        653
Glu Glu Val Leu Asp Leu Phe Asp Thr Thr Arg Asp Ile Asp Ala Lys           
    155                 160                 165                           

agt aaa aaa tca aat ata aga att cat gaa gat tca act gga gga att        701
Ser Lys Lys Ser Asn Ile Arg Ile His Glu Asp Ser Thr Gly Gly Ile           
170                 175                 180                 185           

tat act gtg ggc gtt aca aca cgt act gtg aat aca gaa tca gag atg        749
Tyr Thr Val Gly Val Thr Thr Arg Thr Val Asn Thr Glu Ser Glu Met           
                190                 195                 200               

atg cag tgt ttg aag ttg ggt gct tta tcc cgg aca act gcc agt acc        797
Met Gln Cys Leu Lys Leu Gly Ala Leu Ser Arg Thr Thr Ala Ser Thr           
            205                 210                 215                   

cag atg aat gtt cag agc tct cgt tca cat gcc att ttt acc att cat        845
Gln Met Asn Val Gln Ser Ser Arg Ser His Ala Ile Phe Thr Ile His           
        220                 225                 230                       

gtg tgt caa acc aga gtg tgt ccc caa ata gat gct gac aat gca act        893
Val Cys Gln Thr Arg Val Cys Pro Gln Ile Asp Ala Asp Asn Ala Thr           
    235                 240                 245                           

gat aat aaa att att tct gaa tca gca cag atg aat gaa ttt gaa acc        941
Asp Asn Lys Ile Ile Ser Glu Ser Ala Gln Met Asn Glu Phe Glu Thr           
250                 255                 260                 265           

ctg act gca aag ttc cat ttt gtt gat ctc gca gga tct gaa aga ctg        989
Leu Thr Ala Lys Phe His Phe Val Asp Leu Ala Gly Ser Glu Arg Leu           
                270                 275                 280               

aag cgt act gga gct aca ggc gag agg gca aaa gaa ggc att tct atc       1037
Lys Arg Thr Gly Ala Thr Gly Glu Arg Ala Lys Glu Gly Ile Ser Ile           
            285                 290                 295                   

aac tgt gga ctt ttg gca ctt ggc aat gta ata agt gcc ttg gga gac       1085
Asn Cys Gly Leu Leu Ala Leu Gly Asn Val Ile Ser Ala Leu Gly Asp           
        300                 305                 310                       

aag agc aag agg gcc aca cat gtc ccc tat aga gat tcc aag cta aca       1133
Lys Ser Lys Arg Ala Thr His Val Pro Tyr Arg Asp Ser Lys Leu Thr           
    315                 320                 325                           

aga cta cta cag gat tcc ctc ggg ggt aat agc caa aca atc atg ata       1181
Arg Leu Leu Gln Asp Ser Leu Gly Gly Asn Ser Gln Thr Ile Met Ile           
330                 335                 340                 345           

gca tgt gtc agc cct tca gac aga gac ttt atg gaa acg tta aac acc       1229
Ala Cys Val Ser Pro Ser Asp Arg Asp Phe Met Glu Thr Leu Asn Thr           
                350                 355                 360               

ctg aaa tac gcc aat cga gct aga aat atc aag aat aag gtg atg gtc       1277
Leu Lys Tyr Ala Asn Arg Ala Arg Asn Ile Lys Asn Lys Val Met Val           
            365                 370                 375                   

aat cag gac aga gct agt cag caa atc aat gca ctt cgt agt gaa atc       1325
Asn Gln Asp Arg Ala Ser Gln Gln Ile Asn Ala Leu Arg Ser Glu Ile           
        380                 385                 390                       

aca cga ctt cag atg gag ctc atg gag tac aaa aca ggt aaa aga ata       1373
Thr Arg Leu Gln Met Glu Leu Met Glu Tyr Lys Thr Gly Lys Arg Ile           
    395                 400                 405                           

att gac gaa gag ggt gtg gaa agc atc aat gac atg ttt cat gag aat       1421
Ile Asp Glu Glu Gly Val Glu Ser Ile Asn Asp Met Phe His Glu Asn           
410                 415                 420                 425           

gct atg cta cag act gaa aat aat aac ctg cgt gta aga att aaa gcc       1469
Ala Met Leu Gln Thr Glu Asn Asn Asn Leu Arg Val Arg Ile Lys Ala           
                430                 435                 440               

atg caa gag acg gtt gat gca ttg agg tcc aga att aca cag ctt gtt       1517
Met Gln Glu Thr Val Asp Ala Leu Arg Ser Arg Ile Thr Gln Leu Val           
            445                 450                 455                   

agt gat cag gcc aac cat gtt ctt gcc aga gca ggt gaa gga aat gag       1565
Ser Asp Gln Ala Asn His Val Leu Ala Arg Ala Gly Glu Gly Asn Glu           
        460                 465                 470                       

gag att agt aat atg att cat agt tat ata aaa gaa atc gaa gat ctc       1613
Glu Ile Ser Asn Met Ile His Ser Tyr Ile Lys Glu Ile Glu Asp Leu           
    475                 480                 485                           

agg gca aaa tta tta gaa agt gaa gca gtg aat gag aac ctt cga aaa       1661
Arg Ala Lys Leu Leu Glu Ser Glu Ala Val Asn Glu Asn Leu Arg Lys           
490                 495                 500                 505           

aac ttg aca aga gcc aca gca aga gcg cca tat ttc agc gga tca tca       1709
Asn Leu Thr Arg Ala Thr Ala Arg Ala Pro Tyr Phe Ser Gly Ser Ser           
                510                 515                 520               

act ttt tct cct acc ata cta tcc tca gac aaa gaa acc att gaa att       1757
Thr Phe Ser Pro Thr Ile Leu Ser Ser Asp Lys Glu Thr Ile Glu Ile           
            525                 530                 535                   

ata gac cta gca aaa aaa gat tta gag aag ttg aaa aga aaa gaa aag       1805
Ile Asp Leu Ala Lys Lys Asp Leu Glu Lys Leu Lys Arg Lys Glu Lys           
        540                 545                 550                       

agg aag aaa aaa agt gtg gct ggt aaa gag gat aat aca gac act gac       1853
Arg Lys Lys Lys Ser Val Ala Gly Lys Glu Asp Asn Thr Asp Thr Asp           
    555                 560                 565                           

caa gag aag aaa gaa gaa aag ggt gtt tcg gaa aga gaa aac aat gaa       1901
Gln Glu Lys Lys Glu Glu Lys Gly Val Ser Glu Arg Glu Asn Asn Glu           
570                 575                 580                 585           

tta gaa gtg gaa gaa agt caa gaa gtg agt gat cat gag gat gaa gaa       1949
Leu Glu Val Glu Glu Ser Gln Glu Val Ser Asp His Glu Asp Glu Glu           
                590                 595                 600               

gag gag gag gag gag gag gaa gat gac att gat ggg ggt gaa agt tct       1997
Glu Glu Glu Glu Glu Glu Glu Asp Asp Ile Asp Gly Gly Glu Ser Ser           
            605                 610                 615                   

gat gaa tca gat tct gaa tca gat gaa aaa gcc aat tat caa gca gac       2045
Asp Glu Ser Asp Ser Glu Ser Asp Glu Lys Ala Asn Tyr Gln Ala Asp           
        620                 625                 630                       

ttg gca aac att act tgt gaa att gca att aag caa aag ctg att gat       2093
Leu Ala Asn Ile Thr Cys Glu Ile Ala Ile Lys Gln Lys Leu Ile Asp           
    635                 640                 645                           

gaa cta gaa aac agc cag aaa aga ctg cag act ctg aaa aag cag tat       2141
Glu Leu Glu Asn Ser Gln Lys Arg Leu Gln Thr Leu Lys Lys Gln Tyr           
650                 655                 660                 665           

gaa gag aag cta atg atg ctg caa cat aaa att cgg gat act cag ctt       2189
Glu Glu Lys Leu Met Met Leu Gln His Lys Ile Arg Asp Thr Gln Leu           
                670                 675                 680               

gaa aga gac cag gtg ctt caa aac tta ggc tcg gta gaa tct tac tca       2237
Glu Arg Asp Gln Val Leu Gln Asn Leu Gly Ser Val Glu Ser Tyr Ser           
            685                 690                 695                   

gaa gaa aaa gca aaa aaa gtt agg tct gaa tat gaa aag aaa ctc caa       2285
Glu Glu Lys Ala Lys Lys Val Arg Ser Glu Tyr Glu Lys Lys Leu Gln           
        700                 705                 710                       

gcc atg aac aaa gaa ctg cag aga ctt caa gca gct caa aaa gaa cat       2333
Ala Met Asn Lys Glu Leu Gln Arg Leu Gln Ala Ala Gln Lys Glu His           
    715                 720                 725                           

gca agg ttg ctt aaa aat cag tct cag tat gaa aag caa ttg aag aaa       2381
Ala Arg Leu Leu Lys Asn Gln Ser Gln Tyr Glu Lys Gln Leu Lys Lys           
730                 735                 740                 745           

ttg cag cag gat gtg atg gaa atg aaa aaa aca aag gtt cgc cta atg       2429
Leu Gln Gln Asp Val Met Glu Met Lys Lys Thr Lys Val Arg Leu Met           
                750                 755                 760               

aaa caa atg aaa gaa gaa caa gag aaa gcc aga ctg act gag tct aga       2477
Lys Gln Met Lys Glu Glu Gln Glu Lys Ala Arg Leu Thr Glu Ser Arg           
            765                 770                 775                   

aga aac aga gag att gct cag ttg aaa aag gat caa cgt aaa aga gat       2525
Arg Asn Arg Glu Ile Ala Gln Leu Lys Lys Asp Gln Arg Lys Arg Asp           
        780                 785                 790                       

cat caa ctt aga ctt ctg gaa gcc caa aaa aga aac caa gaa gtg gtt       2573
His Gln Leu Arg Leu Leu Glu Ala Gln Lys Arg Asn Gln Glu Val Val           
    795                 800                 805                           

cta cgt cgc aaa act gaa gag gtt acg gct ctt cgt cgg caa gta aga       2621
Leu Arg Arg Lys Thr Glu Glu Val Thr Ala Leu Arg Arg Gln Val Arg           
810                 815                 820                 825           

ccc atg tca gat aaa gtg gct ggg aaa gtt act cgg aag ctg agt tca       2669
Pro Met Ser Asp Lys Val Ala Gly Lys Val Thr Arg Lys Leu Ser Ser           
                830                 835                 840               

tct gat gca cct gct cag gac aca ggt tcc agt gca gct gct gtc gaa       2717
Ser Asp Ala Pro Ala Gln Asp Thr Gly Ser Ser Ala Ala Ala Val Glu           
            845                 850                 855                   

aca gat gca tca agg aca gga gcc cag cag aaa atg aga att cct gtg       2765
Thr Asp Ala Ser Arg Thr Gly Ala Gln Gln Lys Met Arg Ile Pro Val           
        860                 865                 870                       

gcg aga gtc cag gcc tta cca acg ccg gca aca aat gga aac agg aaa       2813
Ala Arg Val Gln Ala Leu Pro Thr Pro Ala Thr Asn Gly Asn Arg Lys           
    875                 880                 885                           

aaa tat cag agg aaa gga ttg act ggc cga gtg ttt att tcc aag aca       2861
Lys Tyr Gln Arg Lys Gly Leu Thr Gly Arg Val Phe Ile Ser Lys Thr           
890                 895                 900                 905           

gct cgc atg aag tgg cag ctc ctt gag cgc agg gtc aca gac atc atc       2909
Ala Arg Met Lys Trp Gln Leu Leu Glu Arg Arg Val Thr Asp Ile Ile           
                910                 915                 920               

atg cag aag atg acc att tcc aac atg gag gca gat atg aat aga ctc       2957
Met Gln Lys Met Thr Ile Ser Asn Met Glu Ala Asp Met Asn Arg Leu           
            925                 930                 935                   

ctc aag caa cgg gag gaa ctc aca aaa aga cga gag aaa ctt tca aaa       3005
Leu Lys Gln Arg Glu Glu Leu Thr Lys Arg Arg Glu Lys Leu Ser Lys           
        940                 945                 950                       

aga agg gag aag ata gtc aag gag aat gga gag gga gat aaa aat gtg       3053
Arg Arg Glu Lys Ile Val Lys Glu Asn Gly Glu Gly Asp Lys Asn Val           
    955                 960                 965                           

gct aat atc aat gaa gag atg gag tca ctg act gct aat atc gat tac       3101
Ala Asn Ile Asn Glu Glu Met Glu Ser Leu Thr Ala Asn Ile Asp Tyr           
970                 975                 980                 985           

atc aat gac agt att tct gat tgt cag gcc aac ata atg cag atg  gaa      3149
Ile Asn Asp Ser Ile Ser Asp Cys Gln Ala Asn Ile Met Gln Met  Glu          
                990                 995                 1000              

gaa gca aag gaa  gaa ggt gag aca ttg  gat gtt act gca gtc  att        3194
Glu Ala Lys Glu  Glu Gly Glu Thr Leu  Asp Val Thr Ala Val  Ile            
            1005                 1010                 1015                

aat gcc tgc acc  ctt aca gaa gcc cga  tac ctg cta gat cac  ttc        3239
Asn Ala Cys Thr  Leu Thr Glu Ala Arg  Tyr Leu Leu Asp His  Phe            
            1020                 1025                 1030                

ctg tca atg ggc  atc aat aag ggt ctt  cag gct gcc cag aaa  gag        3284
Leu Ser Met Gly  Ile Asn Lys Gly Leu  Gln Ala Ala Gln Lys  Glu            
            1035                 1040                 1045                

gct caa att aaa  gta ctg gaa ggt cga  ctc aaa caa aca gaa  ata        3329
Ala Gln Ile Lys  Val Leu Glu Gly Arg  Leu Lys Gln Thr Glu  Ile            
            1050                 1055                 1060                

acc agt gct acc  caa aac cag ctc tta  ttc cat atg ttg aaa  gag        3374
Thr Ser Ala Thr  Gln Asn Gln Leu Leu  Phe His Met Leu Lys  Glu            
            1065                 1070                 1075                

aag gca gaa tta  aat cct gag cta gat  gct tta cta ggc cat  gct        3419
Lys Ala Glu Leu  Asn Pro Glu Leu Asp  Ala Leu Leu Gly His  Ala            
            1080                 1085                 1090                

tta caa gat cta  gat agc gta cca tta  gaa aat gta gag gat  agt        3464
Leu Gln Asp Leu  Asp Ser Val Pro Leu  Glu Asn Val Glu Asp  Ser            
            1095                 1100                 1105                

act gat gag gat  gct cct tta aac agc  cca gga tca gaa gga  agc        3509
Thr Asp Glu Asp  Ala Pro Leu Asn Ser  Pro Gly Ser Glu Gly  Ser            
            1110                 1115                 1120                

acg ctg tct tca  gat ctc atg aag ctt  tgt ggt gaa gtg aaa  cct        3554
Thr Leu Ser Ser  Asp Leu Met Lys Leu  Cys Gly Glu Val Lys  Pro            
            1125                 1130                 1135                

aag aac aag gcc  cga agg aga acc acc  act cag atg gaa ttg  ctg        3599
Lys Asn Lys Ala  Arg Arg Arg Thr Thr  Thr Gln Met Glu Leu  Leu            
            1140                 1145                 1150                

tat gca gat agc  agt gaa cta gct tca  gac act agt aca gga  gat        3644
Tyr Ala Asp Ser  Ser Glu Leu Ala Ser  Asp Thr Ser Thr Gly  Asp            
            1155                 1160                 1165                

gcc tcc ttg cct  ggc cct ctc aca cct  gtt gca gaa ggg caa  gag        3689
Ala Ser Leu Pro  Gly Pro Leu Thr Pro  Val Ala Glu Gly Gln  Glu            
            1170                 1175                 1180                

att gga atg aat  aca gag aca agt ggt  act tct gct agg gaa  aaa        3734
Ile Gly Met Asn  Thr Glu Thr Ser Gly  Thr Ser Ala Arg Glu  Lys            
            1185                 1190                 1195                

gag ctc tct ccc  cca cct ggc tta cct  tct aag ata ggc agc  att        3779
Glu Leu Ser Pro  Pro Pro Gly Leu Pro  Ser Lys Ile Gly Ser  Ile            
            1200                 1205                 1210                

tcc agg cag tca  tct cta tca gaa aaa  aaa att cca gag cct  tct        3824
Ser Arg Gln Ser  Ser Leu Ser Glu Lys  Lys Ile Pro Glu Pro  Ser            
            1215                 1220                 1225                

cct gta aca agg  aga aag gca tat gag  aaa gca gaa aaa tca  aag        3869
Pro Val Thr Arg  Arg Lys Ala Tyr Glu  Lys Ala Glu Lys Ser  Lys            
            1230                 1235                 1240                

gcc aag gaa caa  aag cac tca gat tct  gga act tca gag gct  agt        3914
Ala Lys Glu Gln  Lys His Ser Asp Ser  Gly Thr Ser Glu Ala  Ser            
            1245                 1250                 1255                

ctt tca cct cct  tct tcc cca cca agc  cgg ccc cgt aat gaa  ctg        3959
Leu Ser Pro Pro  Ser Ser Pro Pro Ser  Arg Pro Arg Asn Glu  Leu            
            1260                 1265                 1270                

aat gtt ttt aat  cgt ctt act gtt tct  cag gga aac aca tca  gtt        4004
Asn Val Phe Asn  Arg Leu Thr Val Ser  Gln Gly Asn Thr Ser  Val            
            1275                 1280                 1285                

cag cag gat aag  tct gat gaa agt gac  tcc tct ctc tcg gag  gta        4049
Gln Gln Asp Lys  Ser Asp Glu Ser Asp  Ser Ser Leu Ser Glu  Val            
            1290                 1295                 1300                

cac aga tcc tcc  aga agg ggc ata atc  aac cca ttt cct gct  tca        4094
His Arg Ser Ser  Arg Arg Gly Ile Ile  Asn Pro Phe Pro Ala  Ser            
            1305                 1310                 1315                

aaa gga atc aga  gct ttt cca ctt cag  tgt att cac ata gct  gaa        4139
Lys Gly Ile Arg  Ala Phe Pro Leu Gln  Cys Ile His Ile Ala  Glu            
            1320                 1325                 1330                

ggg cat aca aaa  gct gtg ctc tgt gtg  gat tct act gat gat  ctc        4184
Gly His Thr Lys  Ala Val Leu Cys Val  Asp Ser Thr Asp Asp  Leu            
            1335                 1340                 1345                

ctc ttc act gga  tca aaa gat cgt act  tgt aaa gta tgg aat  ctg        4229
Leu Phe Thr Gly  Ser Lys Asp Arg Thr  Cys Lys Val Trp Asn  Leu            
            1350                 1355                 1360                

gtg act ggg cag  gaa ata atg tca ctg  ggg ggt cat ccc aac  aat        4274
Val Thr Gly Gln  Glu Ile Met Ser Leu  Gly Gly His Pro Asn  Asn            
            1365                 1370                 1375                

gtc gtg tct gta  aaa tac tgt aat tat  acc agt ttg gtc ttc  act        4319
Val Val Ser Val  Lys Tyr Cys Asn Tyr  Thr Ser Leu Val Phe  Thr            
            1380                 1385                 1390                

gta tca aca tct  tat att aag gtg tgg  gat atc aga gat tca  gca        4364
Val Ser Thr Ser  Tyr Ile Lys Val Trp  Asp Ile Arg Asp Ser  Ala            
            1395                 1400                 1405                

aag tgc att cga  aca cta acg tct tca  ggt caa gtt act ctt  gga        4409
Lys Cys Ile Arg  Thr Leu Thr Ser Ser  Gly Gln Val Thr Leu  Gly            
            1410                 1415                 1420                

gat gct tgt tct  gca agt acc agt cga  aca gta gct att cct  tct        4454
Asp Ala Cys Ser  Ala Ser Thr Ser Arg  Thr Val Ala Ile Pro  Ser            
            1425                 1430                 1435                

gga gag aac cag  atc aat caa att gcc  cta aac cca act ggc  acc        4499
Gly Glu Asn Gln  Ile Asn Gln Ile Ala  Leu Asn Pro Thr Gly  Thr            
            1440                 1445                 1450                

ttc ctc tat gct  gct tct gga aat gct  gtc agg atg tgg gat  ctt        4544
Phe Leu Tyr Ala  Ala Ser Gly Asn Ala  Val Arg Met Trp Asp  Leu            
            1455                 1460                 1465                

aaa agg ttt cag  tct aca gga aag tta  aca gga cac cta ggc  cct        4589
Lys Arg Phe Gln  Ser Thr Gly Lys Leu  Thr Gly His Leu Gly  Pro            
            1470                 1475                 1480                

gtt atg tgc ctt  act gtg gat cag att  tcc agt gga caa gat  cta        4634
Val Met Cys Leu  Thr Val Asp Gln Ile  Ser Ser Gly Gln Asp  Leu            
            1485                 1490                 1495                

atc atc act ggc  tcc aag gat cat tac  atc aaa atg ttt gat  gtt        4679
Ile Ile Thr Gly  Ser Lys Asp His Tyr  Ile Lys Met Phe Asp  Val            
            1500                 1505                 1510                

aca gaa gga gct  ctt ggg act gtg agt  ccc acc cac aat ttt  gaa        4724
Thr Glu Gly Ala  Leu Gly Thr Val Ser  Pro Thr His Asn Phe  Glu            
            1515                 1520                 1525                

ccc cct cat tat  gat ggc ata gaa gca  cta acc att caa ggg  gat        4769
Pro Pro His Tyr  Asp Gly Ile Glu Ala  Leu Thr Ile Gln Gly  Asp            
            1530                 1535                 1540                

aac cta ttt agt  ggg tct aga gat aat  gga atc aag aaa tgg  gac        4814
Asn Leu Phe Ser  Gly Ser Arg Asp Asn  Gly Ile Lys Lys Trp  Asp            
            1545                 1550                 1555                

tta act caa aaa  gac ctt ctt cag caa  gtt cca aat gca cat  aag        4859
Leu Thr Gln Lys  Asp Leu Leu Gln Gln  Val Pro Asn Ala His  Lys            
            1560                 1565                 1570                

gat tgg gtc tgt  gcc ctg gga gtg gtg  cca gac cac cca gtt  ttg        4904
Asp Trp Val Cys  Ala Leu Gly Val Val  Pro Asp His Pro Val  Leu            
            1575                 1580                 1585                

ctc agt ggc tgc  aga ggg ggc att ttg  aaa gtc tgg aac atg  gat        4949
Leu Ser Gly Cys  Arg Gly Gly Ile Leu  Lys Val Trp Asn Met  Asp            
            1590                 1595                 1600                

act ttt atg cca  gtg gga gag atg aag  ggt cat gat agt cct  atc        4994
Thr Phe Met Pro  Val Gly Glu Met Lys  Gly His Asp Ser Pro  Ile            
            1605                 1610                 1615                

aat gcc ata tgt  gtt aat tcc acc cac  att ttt act gca gct  gat        5039
Asn Ala Ile Cys  Val Asn Ser Thr His  Ile Phe Thr Ala Ala  Asp            
            1620                 1625                 1630                

gat cga act gtg  aga att tgg aag gct  cgc aat ttg caa gat  ggt        5084
Asp Arg Thr Val  Arg Ile Trp Lys Ala  Arg Asn Leu Gln Asp  Gly            
            1635                 1640                 1645                

cag atc tct gac  aca gga gat ctg ggg  gaa gat att gcc agt  aat        5129
Gln Ile Ser Asp  Thr Gly Asp Leu Gly  Glu Asp Ile Ala Ser  Asn            
            1650                 1655                 1660                

taa acatgaatga agataggttg taaactgaat gctgtgataa tactctgtat            5182

tctttatgga aaatgttgtc ctgtacttac taggcaaaac gtatgaatcg gattaactgg     5242

aaaatatatc tgaattcaac tgctgactat aaatggtatt ctaataaaat tgtgtactat     5302

cctgtgtgct tagttttaag atcaaccaat agatatatat cctacaattg atatattgct     5362

ttattcacac ttttattgtg gctgaatttt tgtgcctatc tataaaacac actttcaaat     5422

tatttgaatt accaagacgt ctgcttttgt gacagtcaga aaacacacct ggaatacgat     5482

gcagcccacc attaactcat tcatgtagtt tattcaagtg atttatgtat ttaaactaaa     5542

tattgaaaat gttagtcaaa ttgtggtttg cttgtcaggt atttatatca gtctgtagtg     5602

gattcccaaa tttcaaagct cttttaatgt aatggacaaa aataagatat gagaatatta     5662

ttgatgaatt ttcataaggt ggaattgatc ttaatctact aacagagaag ggtagacagt     5722

ttgtgttaaa tgttggcatt tacttgtatt gaccaaagtt ttgcagctct actatattct     5782

gtgctcagga ctaaaatgct gttaattttt tttttttttt ccagtgctgt gcatatattc     5842

tgtgatggga aacattgttg atgtcctaac agaaatatat tttgatctat tttcctatgg     5902

agttgtttct attatgacca tttaattttg tttttattta atagtagtat ttccttccct     5962

tttatctaat tttttatatg ctgctaaata tattttaaat atactatgtt tgcgaacctt     6022

ggtagctatg atgagagcta ttatcatctg tggtgggaaa agctatgtaa ataggtagat     6082

tgtatagaga gactatcttg tgttgtgcct gtatgaattt ttaaaagttg ttgactggat     6142

tttgcaaaag gatgtataat atttctgtct gctcagaata ttaatttgta aattctgcaa     6202

gtttaatttt tatgtagatg gtataacatt tgaaaatatt gtcttatgtg attttttccc     6262

ctgaaaatat ttgcttgtaa atgaaaactt agctagggct taaataaaca tgttgctatg     6322

aaattaaaaa aaa                                                        6335


<210>  274
<211>  1661
<212>  PRT
<213>  Homo sapiens

<400>  274

Met Leu Gly Ala Pro Asp Glu Ser Ser Val Arg Val Ala Val Arg Ile 
1               5                   10                  15      


Arg Pro Gln Leu Ala Lys Glu Lys Ile Glu Gly Cys His Ile Cys Thr 
            20                  25                  30          


Ser Val Thr Pro Gly Glu Pro Gln Val Phe Leu Gly Lys Asp Lys Ala 
        35                  40                  45              


Phe Thr Phe Asp Tyr Val Phe Asp Ile Asp Ser Gln Gln Glu Gln Ile 
    50                  55                  60                  


Tyr Ile Gln Cys Ile Glu Lys Leu Ile Glu Gly Cys Phe Glu Gly Tyr 
65                  70                  75                  80  


Asn Ala Thr Val Phe Ala Tyr Gly Gln Thr Gly Ala Gly Lys Thr Tyr 
                85                  90                  95      


Thr Met Gly Thr Gly Phe Asp Val Asn Ile Val Glu Glu Glu Leu Gly 
            100                 105                 110         


Ile Ile Ser Arg Ala Val Lys His Leu Phe Lys Ser Ile Glu Glu Lys 
        115                 120                 125             


Lys His Ile Ala Ile Lys Asn Gly Leu Pro Ala Pro Asp Phe Lys Val 
    130                 135                 140                 


Asn Ala Gln Phe Leu Glu Leu Tyr Asn Glu Glu Val Leu Asp Leu Phe 
145                 150                 155                 160 


Asp Thr Thr Arg Asp Ile Asp Ala Lys Ser Lys Lys Ser Asn Ile Arg 
                165                 170                 175     


Ile His Glu Asp Ser Thr Gly Gly Ile Tyr Thr Val Gly Val Thr Thr 
            180                 185                 190         


Arg Thr Val Asn Thr Glu Ser Glu Met Met Gln Cys Leu Lys Leu Gly 
        195                 200                 205             


Ala Leu Ser Arg Thr Thr Ala Ser Thr Gln Met Asn Val Gln Ser Ser 
    210                 215                 220                 


Arg Ser His Ala Ile Phe Thr Ile His Val Cys Gln Thr Arg Val Cys 
225                 230                 235                 240 


Pro Gln Ile Asp Ala Asp Asn Ala Thr Asp Asn Lys Ile Ile Ser Glu 
                245                 250                 255     


Ser Ala Gln Met Asn Glu Phe Glu Thr Leu Thr Ala Lys Phe His Phe 
            260                 265                 270         


Val Asp Leu Ala Gly Ser Glu Arg Leu Lys Arg Thr Gly Ala Thr Gly 
        275                 280                 285             


Glu Arg Ala Lys Glu Gly Ile Ser Ile Asn Cys Gly Leu Leu Ala Leu 
    290                 295                 300                 


Gly Asn Val Ile Ser Ala Leu Gly Asp Lys Ser Lys Arg Ala Thr His 
305                 310                 315                 320 


Val Pro Tyr Arg Asp Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser Leu 
                325                 330                 335     


Gly Gly Asn Ser Gln Thr Ile Met Ile Ala Cys Val Ser Pro Ser Asp 
            340                 345                 350         


Arg Asp Phe Met Glu Thr Leu Asn Thr Leu Lys Tyr Ala Asn Arg Ala 
        355                 360                 365             


Arg Asn Ile Lys Asn Lys Val Met Val Asn Gln Asp Arg Ala Ser Gln 
    370                 375                 380                 


Gln Ile Asn Ala Leu Arg Ser Glu Ile Thr Arg Leu Gln Met Glu Leu 
385                 390                 395                 400 


Met Glu Tyr Lys Thr Gly Lys Arg Ile Ile Asp Glu Glu Gly Val Glu 
                405                 410                 415     


Ser Ile Asn Asp Met Phe His Glu Asn Ala Met Leu Gln Thr Glu Asn 
            420                 425                 430         


Asn Asn Leu Arg Val Arg Ile Lys Ala Met Gln Glu Thr Val Asp Ala 
        435                 440                 445             


Leu Arg Ser Arg Ile Thr Gln Leu Val Ser Asp Gln Ala Asn His Val 
    450                 455                 460                 


Leu Ala Arg Ala Gly Glu Gly Asn Glu Glu Ile Ser Asn Met Ile His 
465                 470                 475                 480 


Ser Tyr Ile Lys Glu Ile Glu Asp Leu Arg Ala Lys Leu Leu Glu Ser 
                485                 490                 495     


Glu Ala Val Asn Glu Asn Leu Arg Lys Asn Leu Thr Arg Ala Thr Ala 
            500                 505                 510         


Arg Ala Pro Tyr Phe Ser Gly Ser Ser Thr Phe Ser Pro Thr Ile Leu 
        515                 520                 525             


Ser Ser Asp Lys Glu Thr Ile Glu Ile Ile Asp Leu Ala Lys Lys Asp 
    530                 535                 540                 


Leu Glu Lys Leu Lys Arg Lys Glu Lys Arg Lys Lys Lys Ser Val Ala 
545                 550                 555                 560 


Gly Lys Glu Asp Asn Thr Asp Thr Asp Gln Glu Lys Lys Glu Glu Lys 
                565                 570                 575     


Gly Val Ser Glu Arg Glu Asn Asn Glu Leu Glu Val Glu Glu Ser Gln 
            580                 585                 590         


Glu Val Ser Asp His Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        595                 600                 605             


Asp Asp Ile Asp Gly Gly Glu Ser Ser Asp Glu Ser Asp Ser Glu Ser 
    610                 615                 620                 


Asp Glu Lys Ala Asn Tyr Gln Ala Asp Leu Ala Asn Ile Thr Cys Glu 
625                 630                 635                 640 


Ile Ala Ile Lys Gln Lys Leu Ile Asp Glu Leu Glu Asn Ser Gln Lys 
                645                 650                 655     


Arg Leu Gln Thr Leu Lys Lys Gln Tyr Glu Glu Lys Leu Met Met Leu 
            660                 665                 670         


Gln His Lys Ile Arg Asp Thr Gln Leu Glu Arg Asp Gln Val Leu Gln 
        675                 680                 685             


Asn Leu Gly Ser Val Glu Ser Tyr Ser Glu Glu Lys Ala Lys Lys Val 
    690                 695                 700                 


Arg Ser Glu Tyr Glu Lys Lys Leu Gln Ala Met Asn Lys Glu Leu Gln 
705                 710                 715                 720 


Arg Leu Gln Ala Ala Gln Lys Glu His Ala Arg Leu Leu Lys Asn Gln 
                725                 730                 735     


Ser Gln Tyr Glu Lys Gln Leu Lys Lys Leu Gln Gln Asp Val Met Glu 
            740                 745                 750         


Met Lys Lys Thr Lys Val Arg Leu Met Lys Gln Met Lys Glu Glu Gln 
        755                 760                 765             


Glu Lys Ala Arg Leu Thr Glu Ser Arg Arg Asn Arg Glu Ile Ala Gln 
    770                 775                 780                 


Leu Lys Lys Asp Gln Arg Lys Arg Asp His Gln Leu Arg Leu Leu Glu 
785                 790                 795                 800 


Ala Gln Lys Arg Asn Gln Glu Val Val Leu Arg Arg Lys Thr Glu Glu 
                805                 810                 815     


Val Thr Ala Leu Arg Arg Gln Val Arg Pro Met Ser Asp Lys Val Ala 
            820                 825                 830         


Gly Lys Val Thr Arg Lys Leu Ser Ser Ser Asp Ala Pro Ala Gln Asp 
        835                 840                 845             


Thr Gly Ser Ser Ala Ala Ala Val Glu Thr Asp Ala Ser Arg Thr Gly 
    850                 855                 860                 


Ala Gln Gln Lys Met Arg Ile Pro Val Ala Arg Val Gln Ala Leu Pro 
865                 870                 875                 880 


Thr Pro Ala Thr Asn Gly Asn Arg Lys Lys Tyr Gln Arg Lys Gly Leu 
                885                 890                 895     


Thr Gly Arg Val Phe Ile Ser Lys Thr Ala Arg Met Lys Trp Gln Leu 
            900                 905                 910         


Leu Glu Arg Arg Val Thr Asp Ile Ile Met Gln Lys Met Thr Ile Ser 
        915                 920                 925             


Asn Met Glu Ala Asp Met Asn Arg Leu Leu Lys Gln Arg Glu Glu Leu 
    930                 935                 940                 


Thr Lys Arg Arg Glu Lys Leu Ser Lys Arg Arg Glu Lys Ile Val Lys 
945                 950                 955                 960 


Glu Asn Gly Glu Gly Asp Lys Asn Val Ala Asn Ile Asn Glu Glu Met 
                965                 970                 975     


Glu Ser Leu Thr Ala Asn Ile Asp Tyr Ile Asn Asp Ser Ile Ser Asp 
            980                 985                 990         


Cys Gln Ala Asn Ile Met Gln Met  Glu Glu Ala Lys Glu  Glu Gly Glu 
        995                 1000                 1005             


Thr Leu  Asp Val Thr Ala Val  Ile Asn Ala Cys Thr  Leu Thr Glu 
    1010                 1015                 1020             


Ala Arg  Tyr Leu Leu Asp His  Phe Leu Ser Met Gly  Ile Asn Lys 
    1025                 1030                 1035             


Gly Leu  Gln Ala Ala Gln Lys  Glu Ala Gln Ile Lys  Val Leu Glu 
    1040                 1045                 1050             


Gly Arg  Leu Lys Gln Thr Glu  Ile Thr Ser Ala Thr  Gln Asn Gln 
    1055                 1060                 1065             


Leu Leu  Phe His Met Leu Lys  Glu Lys Ala Glu Leu  Asn Pro Glu 
    1070                 1075                 1080             


Leu Asp  Ala Leu Leu Gly His  Ala Leu Gln Asp Leu  Asp Ser Val 
    1085                 1090                 1095             


Pro Leu  Glu Asn Val Glu Asp  Ser Thr Asp Glu Asp  Ala Pro Leu 
    1100                 1105                 1110             


Asn Ser  Pro Gly Ser Glu Gly  Ser Thr Leu Ser Ser  Asp Leu Met 
    1115                 1120                 1125             


Lys Leu  Cys Gly Glu Val Lys  Pro Lys Asn Lys Ala  Arg Arg Arg 
    1130                 1135                 1140             


Thr Thr  Thr Gln Met Glu Leu  Leu Tyr Ala Asp Ser  Ser Glu Leu 
    1145                 1150                 1155             


Ala Ser  Asp Thr Ser Thr Gly  Asp Ala Ser Leu Pro  Gly Pro Leu 
    1160                 1165                 1170             


Thr Pro  Val Ala Glu Gly Gln  Glu Ile Gly Met Asn  Thr Glu Thr 
    1175                 1180                 1185             


Ser Gly  Thr Ser Ala Arg Glu  Lys Glu Leu Ser Pro  Pro Pro Gly 
    1190                 1195                 1200             


Leu Pro  Ser Lys Ile Gly Ser  Ile Ser Arg Gln Ser  Ser Leu Ser 
    1205                 1210                 1215             


Glu Lys  Lys Ile Pro Glu Pro  Ser Pro Val Thr Arg  Arg Lys Ala 
    1220                 1225                 1230             


Tyr Glu  Lys Ala Glu Lys Ser  Lys Ala Lys Glu Gln  Lys His Ser 
    1235                 1240                 1245             


Asp Ser  Gly Thr Ser Glu Ala  Ser Leu Ser Pro Pro  Ser Ser Pro 
    1250                 1255                 1260             


Pro Ser  Arg Pro Arg Asn Glu  Leu Asn Val Phe Asn  Arg Leu Thr 
    1265                 1270                 1275             


Val Ser  Gln Gly Asn Thr Ser  Val Gln Gln Asp Lys  Ser Asp Glu 
    1280                 1285                 1290             


Ser Asp  Ser Ser Leu Ser Glu  Val His Arg Ser Ser  Arg Arg Gly 
    1295                 1300                 1305             


Ile Ile  Asn Pro Phe Pro Ala  Ser Lys Gly Ile Arg  Ala Phe Pro 
    1310                 1315                 1320             


Leu Gln  Cys Ile His Ile Ala  Glu Gly His Thr Lys  Ala Val Leu 
    1325                 1330                 1335             


Cys Val  Asp Ser Thr Asp Asp  Leu Leu Phe Thr Gly  Ser Lys Asp 
    1340                 1345                 1350             


Arg Thr  Cys Lys Val Trp Asn  Leu Val Thr Gly Gln  Glu Ile Met 
    1355                 1360                 1365             


Ser Leu  Gly Gly His Pro Asn  Asn Val Val Ser Val  Lys Tyr Cys 
    1370                 1375                 1380             


Asn Tyr  Thr Ser Leu Val Phe  Thr Val Ser Thr Ser  Tyr Ile Lys 
    1385                 1390                 1395             


Val Trp  Asp Ile Arg Asp Ser  Ala Lys Cys Ile Arg  Thr Leu Thr 
    1400                 1405                 1410             


Ser Ser  Gly Gln Val Thr Leu  Gly Asp Ala Cys Ser  Ala Ser Thr 
    1415                 1420                 1425             


Ser Arg  Thr Val Ala Ile Pro  Ser Gly Glu Asn Gln  Ile Asn Gln 
    1430                 1435                 1440             


Ile Ala  Leu Asn Pro Thr Gly  Thr Phe Leu Tyr Ala  Ala Ser Gly 
    1445                 1450                 1455             


Asn Ala  Val Arg Met Trp Asp  Leu Lys Arg Phe Gln  Ser Thr Gly 
    1460                 1465                 1470             


Lys Leu  Thr Gly His Leu Gly  Pro Val Met Cys Leu  Thr Val Asp 
    1475                 1480                 1485             


Gln Ile  Ser Ser Gly Gln Asp  Leu Ile Ile Thr Gly  Ser Lys Asp 
    1490                 1495                 1500             


His Tyr  Ile Lys Met Phe Asp  Val Thr Glu Gly Ala  Leu Gly Thr 
    1505                 1510                 1515             


Val Ser  Pro Thr His Asn Phe  Glu Pro Pro His Tyr  Asp Gly Ile 
    1520                 1525                 1530             


Glu Ala  Leu Thr Ile Gln Gly  Asp Asn Leu Phe Ser  Gly Ser Arg 
    1535                 1540                 1545             


Asp Asn  Gly Ile Lys Lys Trp  Asp Leu Thr Gln Lys  Asp Leu Leu 
    1550                 1555                 1560             


Gln Gln  Val Pro Asn Ala His  Lys Asp Trp Val Cys  Ala Leu Gly 
    1565                 1570                 1575             


Val Val  Pro Asp His Pro Val  Leu Leu Ser Gly Cys  Arg Gly Gly 
    1580                 1585                 1590             


Ile Leu  Lys Val Trp Asn Met  Asp Thr Phe Met Pro  Val Gly Glu 
    1595                 1600                 1605             


Met Lys  Gly His Asp Ser Pro  Ile Asn Ala Ile Cys  Val Asn Ser 
    1610                 1615                 1620             


Thr His  Ile Phe Thr Ala Ala  Asp Asp Arg Thr Val  Arg Ile Trp 
    1625                 1630                 1635             


Lys Ala  Arg Asn Leu Gln Asp  Gly Gln Ile Ser Asp  Thr Gly Asp 
    1640                 1645                 1650             


Leu Gly  Glu Asp Ile Ala Ser  Asn 
    1655                 1660     


<210>  275
<211>  3672
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (78)..(1814)

<400>  275
gtcagtccca gcccaagggt agctggaggc gcgcaggccg gctccgctcc ggccccggac       60

gatgcggcgc gcccagg atg ctg ccg tgc ctc gta gtg ctg ctg gcg gcg         110
                   Met Leu Pro Cys Leu Val Val Leu Leu Ala Ala            
                   1               5                   10                 

ctc ctc agc ctc cgt ctt ggc tca gac gct cat ggg aca gag ctg ccc        158
Leu Leu Ser Leu Arg Leu Gly Ser Asp Ala His Gly Thr Glu Leu Pro           
            15                  20                  25                    

agc cct ccg tct gtg tgg ttt gaa gca gaa ttt ttc cac cac atc ctc        206
Ser Pro Pro Ser Val Trp Phe Glu Ala Glu Phe Phe His His Ile Leu           
        30                  35                  40                        

cac tgg aca ccc atc cca aat cag tct gaa agt acc tgc tat gaa gtg        254
His Trp Thr Pro Ile Pro Asn Gln Ser Glu Ser Thr Cys Tyr Glu Val           
    45                  50                  55                            

gcg ctc ctg agg tat gga ata gag tcc tgg aac tcc atc tcc aac tgt        302
Ala Leu Leu Arg Tyr Gly Ile Glu Ser Trp Asn Ser Ile Ser Asn Cys           
60                  65                  70                  75            

agc cag acc ctg tcc tat gac ctt acc gca gtg acc ttg gac ctg tac        350
Ser Gln Thr Leu Ser Tyr Asp Leu Thr Ala Val Thr Leu Asp Leu Tyr           
                80                  85                  90                

cac agc aat ggc tac cgg gcc aga gtg cgg gct gtg gac ggc agc cgg        398
His Ser Asn Gly Tyr Arg Ala Arg Val Arg Ala Val Asp Gly Ser Arg           
            95                  100                 105                   

cac tcc aac tgg acc gtc acc aac acc cgc ttc tct gtg gat gaa gtg        446
His Ser Asn Trp Thr Val Thr Asn Thr Arg Phe Ser Val Asp Glu Val           
        110                 115                 120                       

act ctg aca gtt ggc agt gtg aac cta gag atc cac aat ggc ttc atc        494
Thr Leu Thr Val Gly Ser Val Asn Leu Glu Ile His Asn Gly Phe Ile           
    125                 130                 135                           

ctc ggg aag att cag cta ccc agg ccc aag atg gcc ccc gca aat gac        542
Leu Gly Lys Ile Gln Leu Pro Arg Pro Lys Met Ala Pro Ala Asn Asp           
140                 145                 150                 155           

aca tat gaa agc atc ttc agt cac ttc cga gag tat gag att gcc att        590
Thr Tyr Glu Ser Ile Phe Ser His Phe Arg Glu Tyr Glu Ile Ala Ile           
                160                 165                 170               

cgc aag gtg ccg gga aac ttc acg ttc aca cac aag aaa gta aaa cat        638
Arg Lys Val Pro Gly Asn Phe Thr Phe Thr His Lys Lys Val Lys His           
            175                 180                 185                   

gaa aac ttc agc ctc cta acc tct gga gaa gtg gga gag ttc tgt gtc        686
Glu Asn Phe Ser Leu Leu Thr Ser Gly Glu Val Gly Glu Phe Cys Val           
        190                 195                 200                       

cag gtg aaa cca tct gtc gct tcc cga agt aac aag ggg atg tgg tct        734
Gln Val Lys Pro Ser Val Ala Ser Arg Ser Asn Lys Gly Met Trp Ser           
    205                 210                 215                           

aaa gag gag tgc atc tcc ctc acc agg cag tat ttc acc gtg acc aac        782
Lys Glu Glu Cys Ile Ser Leu Thr Arg Gln Tyr Phe Thr Val Thr Asn           
220                 225                 230                 235           

gtc atc atc ttc ttt gcc ttt gtc ctg ctg ctc tcc gga gcc ctc gcc        830
Val Ile Ile Phe Phe Ala Phe Val Leu Leu Leu Ser Gly Ala Leu Ala           
                240                 245                 250               

tac tgc ctg gcc ctc cag ctg tat gtg cgg cgc cga aag aag cta ccc        878
Tyr Cys Leu Ala Leu Gln Leu Tyr Val Arg Arg Arg Lys Lys Leu Pro           
            255                 260                 265                   

agt gtc ctg ctc ttc aag aag ccc agc ccc ttc atc ttc atc agc cag        926
Ser Val Leu Leu Phe Lys Lys Pro Ser Pro Phe Ile Phe Ile Ser Gln           
        270                 275                 280                       

cgt ccc tcc cca gag acc caa gac acc atc cac ccg ctt gat gag gag        974
Arg Pro Ser Pro Glu Thr Gln Asp Thr Ile His Pro Leu Asp Glu Glu           
    285                 290                 295                           

gcc ttt ttg aag gtg tcc cca gag ctg aag aac ttg gac ctg cac ggc       1022
Ala Phe Leu Lys Val Ser Pro Glu Leu Lys Asn Leu Asp Leu His Gly           
300                 305                 310                 315           

agc aca gac agt ggc ttt ggc agc acc aag cca tcc ctg cag act gaa       1070
Ser Thr Asp Ser Gly Phe Gly Ser Thr Lys Pro Ser Leu Gln Thr Glu           
                320                 325                 330               

gag ccc cag ttc ctc ctc cct gac cct cac ccc cag gct gac aga acg       1118
Glu Pro Gln Phe Leu Leu Pro Asp Pro His Pro Gln Ala Asp Arg Thr           
            335                 340                 345                   

ctg gga aac agg gag ccc cct gtg ctg ggg gac agc tgc agt agt ggc       1166
Leu Gly Asn Arg Glu Pro Pro Val Leu Gly Asp Ser Cys Ser Ser Gly           
        350                 355                 360                       

agc agc aat agc aca gac agc ggg atc tgc ctg cag gag ccc agc ctg       1214
Ser Ser Asn Ser Thr Asp Ser Gly Ile Cys Leu Gln Glu Pro Ser Leu           
    365                 370                 375                           

agc ccc agc aca ggg ccc acc tgg gag caa cag gtg ggg agc aac agc       1262
Ser Pro Ser Thr Gly Pro Thr Trp Glu Gln Gln Val Gly Ser Asn Ser           
380                 385                 390                 395           

agg ggc cag gat gac agt ggc att gac tta gtt caa aac tct gag ggc       1310
Arg Gly Gln Asp Asp Ser Gly Ile Asp Leu Val Gln Asn Ser Glu Gly           
                400                 405                 410               

cgg gct ggg gac aca cag ggt ggc tcg gcc ttg ggc cac cac agt ccc       1358
Arg Ala Gly Asp Thr Gln Gly Gly Ser Ala Leu Gly His His Ser Pro           
            415                 420                 425                   

ccg gag cct gag gtg cct ggg gaa gaa gac cca gct gct gtg gca ttc       1406
Pro Glu Pro Glu Val Pro Gly Glu Glu Asp Pro Ala Ala Val Ala Phe           
        430                 435                 440                       

cag ggt tac ctg agg cag acc aga tgt gct gaa gag aag gca acc aag       1454
Gln Gly Tyr Leu Arg Gln Thr Arg Cys Ala Glu Glu Lys Ala Thr Lys           
    445                 450                 455                           

aca ggc tgc ctg gag gaa gaa tcg ccc ttg aca gat ggc ctt ggc ccc       1502
Thr Gly Cys Leu Glu Glu Glu Ser Pro Leu Thr Asp Gly Leu Gly Pro           
460                 465                 470                 475           

aaa ttc ggg aga tgc ctg gtt gat gag gca ggc ttg cat cca cca gcc       1550
Lys Phe Gly Arg Cys Leu Val Asp Glu Ala Gly Leu His Pro Pro Ala           
                480                 485                 490               

ctg gcc aag ggc tat ttg aaa cag gat cct cta gaa atg act ctg gct       1598
Leu Ala Lys Gly Tyr Leu Lys Gln Asp Pro Leu Glu Met Thr Leu Ala           
            495                 500                 505                   

tcc tca ggg gcc cca acg gga cag tgg aac cag ccc act gag gaa tgg       1646
Ser Ser Gly Ala Pro Thr Gly Gln Trp Asn Gln Pro Thr Glu Glu Trp           
        510                 515                 520                       

tca ctc ctg gcc ttg agc agc tgc agt gac ctg gga ata tct gac tgg       1694
Ser Leu Leu Ala Leu Ser Ser Cys Ser Asp Leu Gly Ile Ser Asp Trp           
    525                 530                 535                           

agc ttt gcc cat gac ctt gcc cct cta ggc tgt gtg gca gcc cca ggt       1742
Ser Phe Ala His Asp Leu Ala Pro Leu Gly Cys Val Ala Ala Pro Gly           
540                 545                 550                 555           

ggt ctc ctg ggc agc ttt aac tca gac ctg gtc acc ctg ccc ctc atc       1790
Gly Leu Leu Gly Ser Phe Asn Ser Asp Leu Val Thr Leu Pro Leu Ile           
                560                 565                 570               

tct agc ctg cag tca agt gag tga ctcgggctga gaggctgctt ttgattttag      1844
Ser Ser Leu Gln Ser Ser Glu                                               
            575                                                           

ccatgcctgc tcctctgcct ggaccaggag gagggcccct ggggcagaag ttaggcacga     1904

ggcagtctgg gcacttttct gcaagtccac tggggctggc cccagccagg ccctgcaggg     1964

ctggtcaggg tgtctggggc aggaggaggc caactcactg aactagtgca gggtatgtgg     2024

gtggcactga cctgttctgt tgactggggc cctgcagact ctggcagagc tgagaagggc     2084

agggaccttc tccctcctag gaactctttc ctgtatcata aaggattatt tgctcagggg     2144

aaccatgggg ctttctggag ttgtggtgag gccaccaggc tgaagtcagc tcagacccag     2204

acctccctgc ttaggccact cgagcatcag agcttccagc aggaggaagg gctgtaggaa     2264

tggaagcttc agggccttgc tgctggggtc atttttaggg gaaaaaggag gatatgatgg     2324

tcacatgggg aacctcccct catcgggcct ctggggcagg aagcttgtca ctggaagatc     2384

ttaaggtata tattttctgg acactcaaac acatcataat ggattcactg aggggagaca     2444

aagggagccg agaccctgga tggggcttcc agctcagaac ccatccctct ggtgggtacc     2504

tctggcaccc atctgcaaat atctccctct ctccaacaaa tggagtagca tccccctggg     2564

gcacttgctg aggccaagcc actcacatcc tcactttgct gccccaccat cttgctgaca     2624

acttccagag aagccatggt tttttgtatt ggtcataact cagccctttg ggcggcctct     2684

gggcttgggc accagctcat gccagcccca gagggtcagg gttggaggcc tgtgcttgtg     2744

tttgctgcta atgtccagct acagacccag aggataagcc actgggcact gggctggggt     2804

ccctgccttg ttggtgttca gctgtgtgat tttggactag ccacttgtca gagggcctca     2864

atctcccatc tgtgaaataa ggactccacc tttaggggac cctccatgtt tgctgggtat     2924

tagccaagct ggtcctggga gaatgcagat actgtccgtg gactaccaag ctggcttgtt     2984

tcttatgcca gaggctaaca gatccaatgg gagtccatgg tgtcatgcca agacagtatc     3044

agacacagcc ccagaagggg gcattatggg ccctgcctcc ccataggcca tttggactct     3104

gccttcaaac aaaggcagtt cagtccacag gcatggaagc tgtgagggga caggcctgtg     3164

cgtgccatcc agagtcatct cagccctgcc tttctctgga gcattctgaa aacagatatt     3224

ctggcccagg gaatccagcc atgaccccca cccctctgcc aaagtactct taggtgccag     3284

tctggtaact gaactccctc tggaggcagg cttgagggag gattcctcag ggttcccttg     3344

aaagctttat ttatttattt tgttcattta tttattggag aggcagcatt gcacagtgaa     3404

agaattctgg atatctcagg agccccgaaa ttctagctct gactttgctg tttccagtgg     3464

tatgaccttg gagaagtcac ttatcctctt ggagcctcag tttcctcatc tgcagaataa     3524

tgactgactt gtctaattcg tagggatgtg aggttctgct gaggaaatgg gtatgaatgt     3584

gccttgaaca caaagctctg tcaataagtg atacatgttt tttattccaa taaattgtca     3644

agaccacagg aaaaaaaaaa aaaaaaaa                                        3672


<210>  276
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  276

Met Leu Pro Cys Leu Val Val Leu Leu Ala Ala Leu Leu Ser Leu Arg 
1               5                   10                  15      


Leu Gly Ser Asp Ala His Gly Thr Glu Leu Pro Ser Pro Pro Ser Val 
            20                  25                  30          


Trp Phe Glu Ala Glu Phe Phe His His Ile Leu His Trp Thr Pro Ile 
        35                  40                  45              


Pro Asn Gln Ser Glu Ser Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr 
    50                  55                  60                  


Gly Ile Glu Ser Trp Asn Ser Ile Ser Asn Cys Ser Gln Thr Leu Ser 
65                  70                  75                  80  


Tyr Asp Leu Thr Ala Val Thr Leu Asp Leu Tyr His Ser Asn Gly Tyr 
                85                  90                  95      


Arg Ala Arg Val Arg Ala Val Asp Gly Ser Arg His Ser Asn Trp Thr 
            100                 105                 110         


Val Thr Asn Thr Arg Phe Ser Val Asp Glu Val Thr Leu Thr Val Gly 
        115                 120                 125             


Ser Val Asn Leu Glu Ile His Asn Gly Phe Ile Leu Gly Lys Ile Gln 
    130                 135                 140                 


Leu Pro Arg Pro Lys Met Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile 
145                 150                 155                 160 


Phe Ser His Phe Arg Glu Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly 
                165                 170                 175     


Asn Phe Thr Phe Thr His Lys Lys Val Lys His Glu Asn Phe Ser Leu 
            180                 185                 190         


Leu Thr Ser Gly Glu Val Gly Glu Phe Cys Val Gln Val Lys Pro Ser 
        195                 200                 205             


Val Ala Ser Arg Ser Asn Lys Gly Met Trp Ser Lys Glu Glu Cys Ile 
    210                 215                 220                 


Ser Leu Thr Arg Gln Tyr Phe Thr Val Thr Asn Val Ile Ile Phe Phe 
225                 230                 235                 240 


Ala Phe Val Leu Leu Leu Ser Gly Ala Leu Ala Tyr Cys Leu Ala Leu 
                245                 250                 255     


Gln Leu Tyr Val Arg Arg Arg Lys Lys Leu Pro Ser Val Leu Leu Phe 
            260                 265                 270         


Lys Lys Pro Ser Pro Phe Ile Phe Ile Ser Gln Arg Pro Ser Pro Glu 
        275                 280                 285             


Thr Gln Asp Thr Ile His Pro Leu Asp Glu Glu Ala Phe Leu Lys Val 
    290                 295                 300                 


Ser Pro Glu Leu Lys Asn Leu Asp Leu His Gly Ser Thr Asp Ser Gly 
305                 310                 315                 320 


Phe Gly Ser Thr Lys Pro Ser Leu Gln Thr Glu Glu Pro Gln Phe Leu 
                325                 330                 335     


Leu Pro Asp Pro His Pro Gln Ala Asp Arg Thr Leu Gly Asn Arg Glu 
            340                 345                 350         


Pro Pro Val Leu Gly Asp Ser Cys Ser Ser Gly Ser Ser Asn Ser Thr 
        355                 360                 365             


Asp Ser Gly Ile Cys Leu Gln Glu Pro Ser Leu Ser Pro Ser Thr Gly 
    370                 375                 380                 


Pro Thr Trp Glu Gln Gln Val Gly Ser Asn Ser Arg Gly Gln Asp Asp 
385                 390                 395                 400 


Ser Gly Ile Asp Leu Val Gln Asn Ser Glu Gly Arg Ala Gly Asp Thr 
                405                 410                 415     


Gln Gly Gly Ser Ala Leu Gly His His Ser Pro Pro Glu Pro Glu Val 
            420                 425                 430         


Pro Gly Glu Glu Asp Pro Ala Ala Val Ala Phe Gln Gly Tyr Leu Arg 
        435                 440                 445             


Gln Thr Arg Cys Ala Glu Glu Lys Ala Thr Lys Thr Gly Cys Leu Glu 
    450                 455                 460                 


Glu Glu Ser Pro Leu Thr Asp Gly Leu Gly Pro Lys Phe Gly Arg Cys 
465                 470                 475                 480 


Leu Val Asp Glu Ala Gly Leu His Pro Pro Ala Leu Ala Lys Gly Tyr 
                485                 490                 495     


Leu Lys Gln Asp Pro Leu Glu Met Thr Leu Ala Ser Ser Gly Ala Pro 
            500                 505                 510         


Thr Gly Gln Trp Asn Gln Pro Thr Glu Glu Trp Ser Leu Leu Ala Leu 
        515                 520                 525             


Ser Ser Cys Ser Asp Leu Gly Ile Ser Asp Trp Ser Phe Ala His Asp 
    530                 535                 540                 


Leu Ala Pro Leu Gly Cys Val Ala Ala Pro Gly Gly Leu Leu Gly Ser 
545                 550                 555                 560 


Phe Asn Ser Asp Leu Val Thr Leu Pro Leu Ile Ser Ser Leu Gln Ser 
                565                 570                 575     


Ser Glu 
        


<210>  277
<211>  1369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (82)..(1083)

<400>  277
attaggtgac tggctgaggc ggcgccagtt ggccgggcac ggggctgctg taaggccgag       60

gttgcggcgg aagcggagac c atg ttc cga gcg gcg gct ccg ggg cag ctc        111
                        Met Phe Arg Ala Ala Ala Pro Gly Gln Leu           
                        1               5                   10            

cgg cgg gcg gcc tca ttg cta cga ttt cag agt acc ctg gta ata gct        159
Arg Arg Ala Ala Ser Leu Leu Arg Phe Gln Ser Thr Leu Val Ile Ala           
                15                  20                  25                

gag cat gca aat gat tcc cta gca ccc att act tta aat acc att act        207
Glu His Ala Asn Asp Ser Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr           
            30                  35                  40                    

gca gcc aca cgc ctt gga ggt gaa gtg tcc tgc tta gta gct gga acc        255
Ala Ala Thr Arg Leu Gly Gly Glu Val Ser Cys Leu Val Ala Gly Thr           
        45                  50                  55                        

aaa tgt gac aag gtg gca caa gat ctc tgt aaa gta gca ggc ata gca        303
Lys Cys Asp Lys Val Ala Gln Asp Leu Cys Lys Val Ala Gly Ile Ala           
    60                  65                  70                            

aaa gtt ctg gtg gct cag cat gat gtg tac aaa ggc cta ctt cca gag        351
Lys Val Leu Val Ala Gln His Asp Val Tyr Lys Gly Leu Leu Pro Glu           
75                  80                  85                  90            

gaa ctg aca cca ttg att ttg gca act cag aag cag ttc aat tac aca        399
Glu Leu Thr Pro Leu Ile Leu Ala Thr Gln Lys Gln Phe Asn Tyr Thr           
                95                  100                 105               

cac atc tgt gct gga gca tct gcc ttc gga aag aac ctt ttg ccc aga        447
His Ile Cys Ala Gly Ala Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg           
            110                 115                 120                   

gta gca gcc aaa ctt gag gtt gcc ccg att tct gac atc att gca atc        495
Val Ala Ala Lys Leu Glu Val Ala Pro Ile Ser Asp Ile Ile Ala Ile           
        125                 130                 135                       

aag tca cct gac aca ttt gtg aga act att tat gca gga aat gct cta        543
Lys Ser Pro Asp Thr Phe Val Arg Thr Ile Tyr Ala Gly Asn Ala Leu           
    140                 145                 150                           

tgt aca gtg aag tgt gat gag aaa gtg aaa gtg ttt tct gtc cgt gga        591
Cys Thr Val Lys Cys Asp Glu Lys Val Lys Val Phe Ser Val Arg Gly           
155                 160                 165                 170           

aca tcc ttt gat gct gca gca aca agt ggc ggt agt gcc agt tca gaa        639
Thr Ser Phe Asp Ala Ala Ala Thr Ser Gly Gly Ser Ala Ser Ser Glu           
                175                 180                 185               

aag gca tca agt act tca cca gtg gaa ata tca gag tgg ctt gac cag        687
Lys Ala Ser Ser Thr Ser Pro Val Glu Ile Ser Glu Trp Leu Asp Gln           
            190                 195                 200                   

aaa tta aca aaa agt gat cga cca gag cta aca ggt gcc aaa gtg gtg        735
Lys Leu Thr Lys Ser Asp Arg Pro Glu Leu Thr Gly Ala Lys Val Val           
        205                 210                 215                       

gta tct ggt ggt cga ggc ttg aag agt gga gag aac ttt aag ttg tta        783
Val Ser Gly Gly Arg Gly Leu Lys Ser Gly Glu Asn Phe Lys Leu Leu           
    220                 225                 230                           

tat gac ttg gca gat caa cta cat gct gca gtt ggt gct tcc cgt gct        831
Tyr Asp Leu Ala Asp Gln Leu His Ala Ala Val Gly Ala Ser Arg Ala           
235                 240                 245                 250           

gct gtt gat gct ggc ttt gtt ccc aat gac atg caa gtt gga cag acg        879
Ala Val Asp Ala Gly Phe Val Pro Asn Asp Met Gln Val Gly Gln Thr           
                255                 260                 265               

gga aaa ata gta gca cca gaa ctt tat att gct gtt gga ata tct gga        927
Gly Lys Ile Val Ala Pro Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly           
            270                 275                 280                   

gcc atc caa cat tta gct ggg atg aaa gac agc aag aca att gtg gca        975
Ala Ile Gln His Leu Ala Gly Met Lys Asp Ser Lys Thr Ile Val Ala           
        285                 290                 295                       

att aat aaa gac cca gaa gct cca att ttc caa gtg gca gat tat gga       1023
Ile Asn Lys Asp Pro Glu Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly           
    300                 305                 310                           

ata gtt gca gat tta ttt aag gta gtt cct gaa atg act gag ata ttg       1071
Ile Val Ala Asp Leu Phe Lys Val Val Pro Glu Met Thr Glu Ile Leu           
315                 320                 325                 330           

aag aaa aaa tga atcaggatca tgccttaaaa agaaaacttt tgttaaagta           1123
Lys Lys Lys                                                               
                                                                          

ttccactgaa atcacagata tttgtgggta ttataacaat cattggaaag catggagagc     1183

tacatttcat aatttgaggg aaaatttcta acagatgcca gaatgcttgt ttatgggatt     1243

gctgtgtttc cttttaatta tttgtggttc caaacaatta ttgtttgaac tttttaaatt     1303

ctgtactaaa atctataata aagcttttcc acagctttaa aactatcaga aaaaaaaaaa     1363

aaaaaa                                                                1369


<210>  278
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  278

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
1               5                   10                  15      


Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
            20                  25                  30          


Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Thr Arg Leu Gly 
        35                  40                  45              


Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Ala 
    50                  55                  60                  


Gln Asp Leu Cys Lys Val Ala Gly Ile Ala Lys Val Leu Val Ala Gln 
65                  70                  75                  80  


His Asp Val Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                85                  90                  95      


Leu Ala Thr Gln Lys Gln Phe Asn Tyr Thr His Ile Cys Ala Gly Ala 
            100                 105                 110         


Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Glu 
        115                 120                 125             


Val Ala Pro Ile Ser Asp Ile Ile Ala Ile Lys Ser Pro Asp Thr Phe 
    130                 135                 140                 


Val Arg Thr Ile Tyr Ala Gly Asn Ala Leu Cys Thr Val Lys Cys Asp 
145                 150                 155                 160 


Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Asp Ala Ala 
                165                 170                 175     


Ala Thr Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Ser Ser Thr Ser 
            180                 185                 190         


Pro Val Glu Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
        195                 200                 205             


Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
    210                 215                 220                 


Leu Lys Ser Gly Glu Asn Phe Lys Leu Leu Tyr Asp Leu Ala Asp Gln 
225                 230                 235                 240 


Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                245                 250                 255     


Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
            260                 265                 270         


Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
        275                 280                 285             


Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
    290                 295                 300                 


Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
305                 310                 315                 320 


Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                325                 330             


<210>  279
<211>  2090
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (109)..(1113)

<400>  279
gttctgggcc taggggaggc gggccgaggg cgtctgagct gaggcccgcg tcgatcctgg       60

gttggaggag gtggcggccg ctgaggctgc ggcgtgaaga cggcgggc atg gtg ggg       117
                                                     Met Val Gly          
                                                     1                    

cgg gag aaa gag ctc tct ata cac ttt gtt ccc ggg agc tgt cgg ctg        165
Arg Glu Lys Glu Leu Ser Ile His Phe Val Pro Gly Ser Cys Arg Leu           
    5                   10                  15                            

gtg gag gag gaa gtt aac atc cct aat agg agg gtt ctg gtt act ggt        213
Val Glu Glu Glu Val Asn Ile Pro Asn Arg Arg Val Leu Val Thr Gly           
20                  25                  30                  35            

gcc act ggg ctt ctt ggc aga gct gta cac aaa gaa ttt cag cag aat        261
Ala Thr Gly Leu Leu Gly Arg Ala Val His Lys Glu Phe Gln Gln Asn           
                40                  45                  50                

aat tgg cat gca gtt ggc tgt ggt ttc aga aga gca aga cca aaa ttt        309
Asn Trp His Ala Val Gly Cys Gly Phe Arg Arg Ala Arg Pro Lys Phe           
            55                  60                  65                    

gaa cag gtt aat ctg ttg gat tct aat gca gtt cat cac atc att cat        357
Glu Gln Val Asn Leu Leu Asp Ser Asn Ala Val His His Ile Ile His           
        70                  75                  80                        

gat ttt cag ccc cat gtt ata gta cat tgt gca gca gag aga aga cca        405
Asp Phe Gln Pro His Val Ile Val His Cys Ala Ala Glu Arg Arg Pro           
    85                  90                  95                            

gat gtt gta gaa aat cag cca gat gct gcc tct caa ctt aat gtg gat        453
Asp Val Val Glu Asn Gln Pro Asp Ala Ala Ser Gln Leu Asn Val Asp           
100                 105                 110                 115           

gct tct ggg aat tta gca aag gaa gca gct gct gtt gga gca ttt ctc        501
Ala Ser Gly Asn Leu Ala Lys Glu Ala Ala Ala Val Gly Ala Phe Leu           
                120                 125                 130               

atc tac att agc tca gat tat gta ttt gat gga aca aat cca cct tac        549
Ile Tyr Ile Ser Ser Asp Tyr Val Phe Asp Gly Thr Asn Pro Pro Tyr           
            135                 140                 145                   

aga gag gaa gac ata cca gct ccc cta aat ttg tat ggc aaa aca aaa        597
Arg Glu Glu Asp Ile Pro Ala Pro Leu Asn Leu Tyr Gly Lys Thr Lys           
        150                 155                 160                       

tta gat gga gaa aag gct gtc ctg gag aac aat cta gga gct gct gtt        645
Leu Asp Gly Glu Lys Ala Val Leu Glu Asn Asn Leu Gly Ala Ala Val           
    165                 170                 175                           

ttg agg att cct att ctg tat ggg gaa gtt gaa aag ctc gaa gaa agt        693
Leu Arg Ile Pro Ile Leu Tyr Gly Glu Val Glu Lys Leu Glu Glu Ser           
180                 185                 190                 195           

gct gtg act gtt atg ttt gat aaa gtg cag ttc agc aac aag tca gca        741
Ala Val Thr Val Met Phe Asp Lys Val Gln Phe Ser Asn Lys Ser Ala           
                200                 205                 210               

aac atg gat cac tgg cag cag agg ttc ccc aca cat gtc aaa gat gtg        789
Asn Met Asp His Trp Gln Gln Arg Phe Pro Thr His Val Lys Asp Val           
            215                 220                 225                   

gcc act gtg tgc cgg cag cta gca gag aag aga atg ctg gat cca tca        837
Ala Thr Val Cys Arg Gln Leu Ala Glu Lys Arg Met Leu Asp Pro Ser           
        230                 235                 240                       

att aag gga acc ttt cac tgg tct ggc aat gaa cag atg act aag tat        885
Ile Lys Gly Thr Phe His Trp Ser Gly Asn Glu Gln Met Thr Lys Tyr           
    245                 250                 255                           

gaa atg gca tgt gca att gca gat gcc ttc aac ctc ccc agc agt cac        933
Glu Met Ala Cys Ala Ile Ala Asp Ala Phe Asn Leu Pro Ser Ser His           
260                 265                 270                 275           

tta aga cct att act gac agc cct gtc cta gga gca caa cgt ccg aga        981
Leu Arg Pro Ile Thr Asp Ser Pro Val Leu Gly Ala Gln Arg Pro Arg           
                280                 285                 290               

aat gct cag ctt gac tgc tcc aaa ttg gag acc ttg ggc att ggc caa       1029
Asn Ala Gln Leu Asp Cys Ser Lys Leu Glu Thr Leu Gly Ile Gly Gln           
            295                 300                 305                   

cga aca cca ttt cga att gga atc aaa gaa tca ctt tgg cct ttc ctc       1077
Arg Thr Pro Phe Arg Ile Gly Ile Lys Glu Ser Leu Trp Pro Phe Leu           
        310                 315                 320                       

att gac aag aga tgg aga caa acg gtc ttt cat tag tttatttgtg            1123
Ile Asp Lys Arg Trp Arg Gln Thr Val Phe His                               
    325                 330                                               

ttgggttctt tttttttttt aaatgaaaag tatagtatgt ggcacttttt aaagaacaaa     1183

ggaaatagtt ttgtatgagt actttaattg tgactcttag gatctttcag gtaaatgatg     1243

ctcttgcact agtgaaattg tctaaagaaa ctaaagggca gtcatgccct gtttgcagta     1303

atttttcttt ttatcatttt gtttgtcctg gctaaacttg gagtttgagt atagtaaatt     1363

atgatcctta aatatttgag agtcaggatg aagcagatct gctgtagact tttcagatga     1423

aattgttcat tctcgtaacc tccatatttt caggattttt gaagctgttg accttttcat     1483

gttgattatt ttaaattgtg tgaaatagta taaaaatcat tggtgttcat tatttgcttt     1543

gcctgagctc agatcaaaat gtttgaagaa aggaacttta tttttgcaag ttacgtacag     1603

tttttatgct tgagatattt caacatgtta tgtatattgg aacttctaca gcttgatgcc     1663

tcctgctttt atagcagttt atggggagca cttgaaagag cgtgtgtaca tgtatttttt     1723

ttctaggcaa acattgaatg caaacgtgta tttttttaat ataaatatat aactgtcctt     1783

ttcatcccat gttgccgcta agtgatattt catatgtgtg gttatactca taataatggg     1843

ccttgtaagt cttttcacca ttcatgaata ataataaata tgtactgctg gcatgtaatg     1903

cttagttttc ttgtatttac ttcttttttt aaatgtaagg accaaacttc taaactaatt     1963

gttcttttgt tgctttaatt tttaaaaatt acattcttct gatgtaacat gtgatacata     2023

caaaagaata tagtttaata tgtattgaaa taaaacacaa taaaattaaa aaaaaaaaaa     2083

aaaaaaa                                                               2090


<210>  280
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  280

Met Val Gly Arg Glu Lys Glu Leu Ser Ile His Phe Val Pro Gly Ser 
1               5                   10                  15      


Cys Arg Leu Val Glu Glu Glu Val Asn Ile Pro Asn Arg Arg Val Leu 
            20                  25                  30          


Val Thr Gly Ala Thr Gly Leu Leu Gly Arg Ala Val His Lys Glu Phe 
        35                  40                  45              


Gln Gln Asn Asn Trp His Ala Val Gly Cys Gly Phe Arg Arg Ala Arg 
    50                  55                  60                  


Pro Lys Phe Glu Gln Val Asn Leu Leu Asp Ser Asn Ala Val His His 
65                  70                  75                  80  


Ile Ile His Asp Phe Gln Pro His Val Ile Val His Cys Ala Ala Glu 
                85                  90                  95      


Arg Arg Pro Asp Val Val Glu Asn Gln Pro Asp Ala Ala Ser Gln Leu 
            100                 105                 110         


Asn Val Asp Ala Ser Gly Asn Leu Ala Lys Glu Ala Ala Ala Val Gly 
        115                 120                 125             


Ala Phe Leu Ile Tyr Ile Ser Ser Asp Tyr Val Phe Asp Gly Thr Asn 
    130                 135                 140                 


Pro Pro Tyr Arg Glu Glu Asp Ile Pro Ala Pro Leu Asn Leu Tyr Gly 
145                 150                 155                 160 


Lys Thr Lys Leu Asp Gly Glu Lys Ala Val Leu Glu Asn Asn Leu Gly 
                165                 170                 175     


Ala Ala Val Leu Arg Ile Pro Ile Leu Tyr Gly Glu Val Glu Lys Leu 
            180                 185                 190         


Glu Glu Ser Ala Val Thr Val Met Phe Asp Lys Val Gln Phe Ser Asn 
        195                 200                 205             


Lys Ser Ala Asn Met Asp His Trp Gln Gln Arg Phe Pro Thr His Val 
    210                 215                 220                 


Lys Asp Val Ala Thr Val Cys Arg Gln Leu Ala Glu Lys Arg Met Leu 
225                 230                 235                 240 


Asp Pro Ser Ile Lys Gly Thr Phe His Trp Ser Gly Asn Glu Gln Met 
                245                 250                 255     


Thr Lys Tyr Glu Met Ala Cys Ala Ile Ala Asp Ala Phe Asn Leu Pro 
            260                 265                 270         


Ser Ser His Leu Arg Pro Ile Thr Asp Ser Pro Val Leu Gly Ala Gln 
        275                 280                 285             


Arg Pro Arg Asn Ala Gln Leu Asp Cys Ser Lys Leu Glu Thr Leu Gly 
    290                 295                 300                 


Ile Gly Gln Arg Thr Pro Phe Arg Ile Gly Ile Lys Glu Ser Leu Trp 
305                 310                 315                 320 


Pro Phe Leu Ile Asp Lys Arg Trp Arg Gln Thr Val Phe His 
                325                 330                 


<210>  281
<211>  2154
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (259)..(2016)

<400>  281
gacgcgagga gggaaggggc gtctgtgggc gggacctccc gggattggag tgaagagggt       60

atctgcttga cagtggatcc ctggggatct acgctgagtt cggagatgct ccagctcggg      120

ccgcccctgt ctgagcggag ctttgcggcg ctgaagctta caggggaagg aaaagcctcg      180

cccggcgtct gattggcgga accgcgctgc cgcagcctgg gattccccag ggaccccccc      240

ggagccgccg cgtctccc atg gac ttg ccc ggg gac tcc agc ccg cct ggc        291
                    Met Asp Leu Pro Gly Asp Ser Ser Pro Pro Gly           
                    1               5                   10                

cag ccg cgt ctg tgc cgc cag cct ctg act cga gca tta tgg gga gcc        339
Gln Pro Arg Leu Cys Arg Gln Pro Leu Thr Arg Ala Leu Trp Gly Ala           
            15                  20                  25                    

agg agc ccg aaa cgg ccg agg ctg cag ctc ccg ggg gcc cct tct ccc        387
Arg Ser Pro Lys Arg Pro Arg Leu Gln Leu Pro Gly Ala Pro Ser Pro           
        30                  35                  40                        

ctg gaa aag gcc tct cgg cgg gtc ctg gcc gtg gtg cta gaa gat gtc        435
Leu Glu Lys Ala Ser Arg Arg Val Leu Ala Val Val Leu Glu Asp Val           
    45                  50                  55                            

atg gct gtt cac atg gtc ccc gtg gtg ccc tca aag cag acc tcc ata        483
Met Ala Val His Met Val Pro Val Val Pro Ser Lys Gln Thr Ser Ile           
60                  65                  70                  75            

cca cag cac cac agc tac cat cag gat cct gtc cac agg cag ccg cct        531
Pro Gln His His Ser Tyr His Gln Asp Pro Val His Arg Gln Pro Pro           
                80                  85                  90                

gcc tcg cca ccc cgg cag gcc ggg tgg tcc tcg cag gcc agg cct ccc        579
Ala Ser Pro Pro Arg Gln Ala Gly Trp Ser Ser Gln Ala Arg Pro Pro           
            95                  100                 105                   

gac cct ctg tgt ttg tgt cgc gag ccc ttg agc cgc atc cac cgg acc        627
Asp Pro Leu Cys Leu Cys Arg Glu Pro Leu Ser Arg Ile His Arg Thr           
        110                 115                 120                       

tct tcc acc ctg agg cgg cga tca agg aca acc cct ggc cca gag gag        675
Ser Ser Thr Leu Arg Arg Arg Ser Arg Thr Thr Pro Gly Pro Glu Glu           
    125                 130                 135                           

ggc cct tca caa aag gtg gac cgg gcc ccc cag ccc acc ctg gtg gtg        723
Gly Pro Ser Gln Lys Val Asp Arg Ala Pro Gln Pro Thr Leu Val Val           
140                 145                 150                 155           

atg ctg gaa gac atc gcc agt cct aga ccc ccc gct gag ggc ttc att        771
Met Leu Glu Asp Ile Ala Ser Pro Arg Pro Pro Ala Glu Gly Phe Ile           
                160                 165                 170               

gat gag acc ccc aac ttc atc atc cca gca caa aga gct gag ccc atg        819
Asp Glu Thr Pro Asn Phe Ile Ile Pro Ala Gln Arg Ala Glu Pro Met           
            175                 180                 185                   

agg ata gtt cgc cag cca acg cct cca cct ggg gac cta gaa ccc cca        867
Arg Ile Val Arg Gln Pro Thr Pro Pro Pro Gly Asp Leu Glu Pro Pro           
        190                 195                 200                       

ttc cag cca tct gct ctg cct gca gac cct ctg gag agc cca cca aca        915
Phe Gln Pro Ser Ala Leu Pro Ala Asp Pro Leu Glu Ser Pro Pro Thr           
    205                 210                 215                           

gcc cca gat cct gct ctg gag ctc cca tcc acc cca cca ccg tcc agc        963
Ala Pro Asp Pro Ala Leu Glu Leu Pro Ser Thr Pro Pro Pro Ser Ser           
220                 225                 230                 235           

ctt tta cgc ccc cgc ctc agt ccc tgg ggc ttg gcc ccg ctc ttc cgt       1011
Leu Leu Arg Pro Arg Leu Ser Pro Trp Gly Leu Ala Pro Leu Phe Arg           
                240                 245                 250               

tcc gtc cgc tcc aag ctg gag agc ttt gct gac atc ttc ctc acg ccc       1059
Ser Val Arg Ser Lys Leu Glu Ser Phe Ala Asp Ile Phe Leu Thr Pro           
            255                 260                 265                   

aac aaa acc cca cag ccc cca ccc ccg tcc ccc cca atg aag ctg gag       1107
Asn Lys Thr Pro Gln Pro Pro Pro Pro Ser Pro Pro Met Lys Leu Glu           
        270                 275                 280                       

ttg aag atc gcc atc tca gag gcc gag cag tct ggg gct gct gag ggc       1155
Leu Lys Ile Ala Ile Ser Glu Ala Glu Gln Ser Gly Ala Ala Glu Gly           
    285                 290                 295                           

act gcg tct gtc agc ccc cgg ccc cca atc cgc cag tgg cga act cag       1203
Thr Ala Ser Val Ser Pro Arg Pro Pro Ile Arg Gln Trp Arg Thr Gln           
300                 305                 310                 315           

gac cac aat acc cca gca ctt ctc cct aag ccc tct ctg ggc cga agc       1251
Asp His Asn Thr Pro Ala Leu Leu Pro Lys Pro Ser Leu Gly Arg Ser           
                320                 325                 330               

tac tcc tgc cct gat ctg ggg ccc cct ggc cca ggt acc tgc acc tgg       1299
Tyr Ser Cys Pro Asp Leu Gly Pro Pro Gly Pro Gly Thr Cys Thr Trp           
            335                 340                 345                   

cca cct gct cca ccc caa cca agc cga cca cgg ccg cgg cgg cac act       1347
Pro Pro Ala Pro Pro Gln Pro Ser Arg Pro Arg Pro Arg Arg His Thr           
        350                 355                 360                       

gtg ggt ggt ggg gaa atg gcc cga gcc ccg cca ccc cct cgg ccc tgt       1395
Val Gly Gly Gly Glu Met Ala Arg Ala Pro Pro Pro Pro Arg Pro Cys           
    365                 370                 375                           

ctc cgg aaa gag gtc ttc cct ctc gga gga gtg gga gcc tcc cct tct       1443
Leu Arg Lys Glu Val Phe Pro Leu Gly Gly Val Gly Ala Ser Pro Ser           
380                 385                 390                 395           

ctc acc aca tct tgc tcg tcc acg gca tcc act tcc ttc tcc gaa cca       1491
Leu Thr Thr Ser Cys Ser Ser Thr Ala Ser Thr Ser Phe Ser Glu Pro           
                400                 405                 410               

gca gaa ccc agg ttg ggt tca acc aaa ggg aag gag cca aga gcc tca       1539
Ala Glu Pro Arg Leu Gly Ser Thr Lys Gly Lys Glu Pro Arg Ala Ser           
            415                 420                 425                   

aag gac cag gtg ctt tca gaa cct gag acc aag acc atg gga aag gtt       1587
Lys Asp Gln Val Leu Ser Glu Pro Glu Thr Lys Thr Met Gly Lys Val           
        430                 435                 440                       

tct cga ttc aga ata cgc aga aca cca gcc cgt cct cag cta aac ctt       1635
Ser Arg Phe Arg Ile Arg Arg Thr Pro Ala Arg Pro Gln Leu Asn Leu           
    445                 450                 455                           

aca cca atg gga ctg cct cga cca atc agg ttg aac aag aag gag ttc       1683
Thr Pro Met Gly Leu Pro Arg Pro Ile Arg Leu Asn Lys Lys Glu Phe           
460                 465                 470                 475           

agc ttg gaa gaa att tac acc aac aag aat tac caa tca ccc aca acc       1731
Ser Leu Glu Glu Ile Tyr Thr Asn Lys Asn Tyr Gln Ser Pro Thr Thr           
                480                 485                 490               

agg agg acc ttt gag acc atc ttt gag gaa ccc cgg gag cgc aat ggg       1779
Arg Arg Thr Phe Glu Thr Ile Phe Glu Glu Pro Arg Glu Arg Asn Gly           
            495                 500                 505                   

act ctg att ttc acc agc tca agg aag ctc cgg cgg gct gtg gaa ttt       1827
Thr Leu Ile Phe Thr Ser Ser Arg Lys Leu Arg Arg Ala Val Glu Phe           
        510                 515                 520                       

cgg gac agc agc ctt cct cga tca cga aga ccg tcc cgt ggg gtc cgg       1875
Arg Asp Ser Ser Leu Pro Arg Ser Arg Arg Pro Ser Arg Gly Val Arg           
    525                 530                 535                           

gct gca ggg ggc agg act gtt cct ccc aat gtg gcc ccc agc cct gat       1923
Ala Ala Gly Gly Arg Thr Val Pro Pro Asn Val Ala Pro Ser Pro Asp           
540                 545                 550                 555           

gtg ggc ccc ctg ctc cag cag cgg ctg gag gag cta gat gcc ttg ctc       1971
Val Gly Pro Leu Leu Gln Gln Arg Leu Glu Glu Leu Asp Ala Leu Leu           
                560                 565                 570               

ctg gag gaa gaa aca gta gat cgg gag cag ccc cac tgg acc tag           2016
Leu Glu Glu Glu Thr Val Asp Arg Glu Gln Pro His Trp Thr                   
            575                 580                 585                   

gtgccccatc tgttggtcat ccatcctgaa gggacaggaa acctcccagg cagttatttt     2076

tttttctcta tatttctagt aaagttttcg atatgtttct gaaaaaaaaa aaaaaaaaaa     2136

aaaaaaaaaa aaaaaaaa                                                   2154


<210>  282
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Asp Leu Pro Gly Asp Ser Ser Pro Pro Gly Gln Pro Arg Leu Cys 
1               5                   10                  15      


Arg Gln Pro Leu Thr Arg Ala Leu Trp Gly Ala Arg Ser Pro Lys Arg 
            20                  25                  30          


Pro Arg Leu Gln Leu Pro Gly Ala Pro Ser Pro Leu Glu Lys Ala Ser 
        35                  40                  45              


Arg Arg Val Leu Ala Val Val Leu Glu Asp Val Met Ala Val His Met 
    50                  55                  60                  


Val Pro Val Val Pro Ser Lys Gln Thr Ser Ile Pro Gln His His Ser 
65                  70                  75                  80  


Tyr His Gln Asp Pro Val His Arg Gln Pro Pro Ala Ser Pro Pro Arg 
                85                  90                  95      


Gln Ala Gly Trp Ser Ser Gln Ala Arg Pro Pro Asp Pro Leu Cys Leu 
            100                 105                 110         


Cys Arg Glu Pro Leu Ser Arg Ile His Arg Thr Ser Ser Thr Leu Arg 
        115                 120                 125             


Arg Arg Ser Arg Thr Thr Pro Gly Pro Glu Glu Gly Pro Ser Gln Lys 
    130                 135                 140                 


Val Asp Arg Ala Pro Gln Pro Thr Leu Val Val Met Leu Glu Asp Ile 
145                 150                 155                 160 


Ala Ser Pro Arg Pro Pro Ala Glu Gly Phe Ile Asp Glu Thr Pro Asn 
                165                 170                 175     


Phe Ile Ile Pro Ala Gln Arg Ala Glu Pro Met Arg Ile Val Arg Gln 
            180                 185                 190         


Pro Thr Pro Pro Pro Gly Asp Leu Glu Pro Pro Phe Gln Pro Ser Ala 
        195                 200                 205             


Leu Pro Ala Asp Pro Leu Glu Ser Pro Pro Thr Ala Pro Asp Pro Ala 
    210                 215                 220                 


Leu Glu Leu Pro Ser Thr Pro Pro Pro Ser Ser Leu Leu Arg Pro Arg 
225                 230                 235                 240 


Leu Ser Pro Trp Gly Leu Ala Pro Leu Phe Arg Ser Val Arg Ser Lys 
                245                 250                 255     


Leu Glu Ser Phe Ala Asp Ile Phe Leu Thr Pro Asn Lys Thr Pro Gln 
            260                 265                 270         


Pro Pro Pro Pro Ser Pro Pro Met Lys Leu Glu Leu Lys Ile Ala Ile 
        275                 280                 285             


Ser Glu Ala Glu Gln Ser Gly Ala Ala Glu Gly Thr Ala Ser Val Ser 
    290                 295                 300                 


Pro Arg Pro Pro Ile Arg Gln Trp Arg Thr Gln Asp His Asn Thr Pro 
305                 310                 315                 320 


Ala Leu Leu Pro Lys Pro Ser Leu Gly Arg Ser Tyr Ser Cys Pro Asp 
                325                 330                 335     


Leu Gly Pro Pro Gly Pro Gly Thr Cys Thr Trp Pro Pro Ala Pro Pro 
            340                 345                 350         


Gln Pro Ser Arg Pro Arg Pro Arg Arg His Thr Val Gly Gly Gly Glu 
        355                 360                 365             


Met Ala Arg Ala Pro Pro Pro Pro Arg Pro Cys Leu Arg Lys Glu Val 
    370                 375                 380                 


Phe Pro Leu Gly Gly Val Gly Ala Ser Pro Ser Leu Thr Thr Ser Cys 
385                 390                 395                 400 


Ser Ser Thr Ala Ser Thr Ser Phe Ser Glu Pro Ala Glu Pro Arg Leu 
                405                 410                 415     


Gly Ser Thr Lys Gly Lys Glu Pro Arg Ala Ser Lys Asp Gln Val Leu 
            420                 425                 430         


Ser Glu Pro Glu Thr Lys Thr Met Gly Lys Val Ser Arg Phe Arg Ile 
        435                 440                 445             


Arg Arg Thr Pro Ala Arg Pro Gln Leu Asn Leu Thr Pro Met Gly Leu 
    450                 455                 460                 


Pro Arg Pro Ile Arg Leu Asn Lys Lys Glu Phe Ser Leu Glu Glu Ile 
465                 470                 475                 480 


Tyr Thr Asn Lys Asn Tyr Gln Ser Pro Thr Thr Arg Arg Thr Phe Glu 
                485                 490                 495     


Thr Ile Phe Glu Glu Pro Arg Glu Arg Asn Gly Thr Leu Ile Phe Thr 
            500                 505                 510         


Ser Ser Arg Lys Leu Arg Arg Ala Val Glu Phe Arg Asp Ser Ser Leu 
        515                 520                 525             


Pro Arg Ser Arg Arg Pro Ser Arg Gly Val Arg Ala Ala Gly Gly Arg 
    530                 535                 540                 


Thr Val Pro Pro Asn Val Ala Pro Ser Pro Asp Val Gly Pro Leu Leu 
545                 550                 555                 560 


Gln Gln Arg Leu Glu Glu Leu Asp Ala Leu Leu Leu Glu Glu Glu Thr 
                565                 570                 575     


Val Asp Arg Glu Gln Pro His Trp Thr 
            580                 585 


<210>  283
<211>  3846
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (433)..(1458)

<400>  283
gcagtgcgca cgtcaaagcc gggctcgggc cgcaagcggg gcgaggggtt cggggagcgg       60

cgcggcctgg gagacacaga gccttcaggc gccggggcgg gggcacaggc gaagactaag      120

gcggcgccgg gccccacagc agcagccgca gcccaagcga gcgcagcagc gcggcggcag      180

ccgcgggagc ccctgggcag ccgtccgccc gcgcagccgc cgccgccgcg ggagcccgtc      240

gccgggagca ggagcgggcg gaagacaacg gaggggccga gcgtccgagc cactccgcgg      300

ggaccgaacg agcagcccga agcggcggcg gccgaggacg gggacagcga cgacgcggag      360

gcagagaagg gaacgcccgg cccagccccg tagcacaggc ggagtgcagc ggaggcccct      420

gccgctgccg tc atg ccg ttc ccg ttt ggg aag tct cac aaa tct cca gca      471
              Met Pro Phe Pro Phe Gly Lys Ser His Lys Ser Pro Ala         
              1               5                   10                      

gac att gtg aag aat ctg aag gag agc atg gct gtt ctg gaa aag caa        519
Asp Ile Val Lys Asn Leu Lys Glu Ser Met Ala Val Leu Glu Lys Gln           
    15                  20                  25                            

gac att tct gat aaa aaa gca gaa aag gct aca gaa gaa gtt tcc aaa        567
Asp Ile Ser Asp Lys Lys Ala Glu Lys Ala Thr Glu Glu Val Ser Lys           
30                  35                  40                  45            

aat ctg gtt gcc atg aaa gaa att ctg tat ggc aca aat gaa aaa gag        615
Asn Leu Val Ala Met Lys Glu Ile Leu Tyr Gly Thr Asn Glu Lys Glu           
                50                  55                  60                

cct cag aca gaa gca gta gct caa ctt gct caa gaa ctc tat aat agt        663
Pro Gln Thr Glu Ala Val Ala Gln Leu Ala Gln Glu Leu Tyr Asn Ser           
            65                  70                  75                    

ggg ctc ctt agc acc ctg gta gct gat tta cag ctc att gac ttt gag        711
Gly Leu Leu Ser Thr Leu Val Ala Asp Leu Gln Leu Ile Asp Phe Glu           
        80                  85                  90                        

ggc aaa aaa gac gtg gct caa att ttc aac aat att ctc aga aga caa        759
Gly Lys Lys Asp Val Ala Gln Ile Phe Asn Asn Ile Leu Arg Arg Gln           
    95                  100                 105                           

att ggt acg aga act cct act gtt gaa tac atc tgc acc caa cag aat        807
Ile Gly Thr Arg Thr Pro Thr Val Glu Tyr Ile Cys Thr Gln Gln Asn           
110                 115                 120                 125           

att ttg ttc atg tta ttg aaa ggg tat gaa tct cca gaa ata gct cta        855
Ile Leu Phe Met Leu Leu Lys Gly Tyr Glu Ser Pro Glu Ile Ala Leu           
                130                 135                 140               

aat tgt gga ata atg tta aga gaa tgc atc aga cat gaa cca ctt gca        903
Asn Cys Gly Ile Met Leu Arg Glu Cys Ile Arg His Glu Pro Leu Ala           
            145                 150                 155                   

aaa atc att ttg tgg tcg gaa cag ttt tat gat ttc ttc aga tat gtc        951
Lys Ile Ile Leu Trp Ser Glu Gln Phe Tyr Asp Phe Phe Arg Tyr Val           
        160                 165                 170                       

gaa atg tca aca ttt gac ata gct tca gat gca ttt gcc aca ttc aag        999
Glu Met Ser Thr Phe Asp Ile Ala Ser Asp Ala Phe Ala Thr Phe Lys           
    175                 180                 185                           

gat tta ctt aca aga cat aaa ttg ctc agt gca gaa ttt ttg gaa cag       1047
Asp Leu Leu Thr Arg His Lys Leu Leu Ser Ala Glu Phe Leu Glu Gln           
190                 195                 200                 205           

cat tat gat aga ttt ttc agt gaa tat gag aag tta ctt cat tca gaa       1095
His Tyr Asp Arg Phe Phe Ser Glu Tyr Glu Lys Leu Leu His Ser Glu           
                210                 215                 220               

aat tat gtg aca aaa aga cag tca ctg aag ctt ctc ggt gaa cta cta       1143
Asn Tyr Val Thr Lys Arg Gln Ser Leu Lys Leu Leu Gly Glu Leu Leu           
            225                 230                 235                   

cta gat aga cac aac ttc aca att atg aca aaa tac atc agt aaa cct       1191
Leu Asp Arg His Asn Phe Thr Ile Met Thr Lys Tyr Ile Ser Lys Pro           
        240                 245                 250                       

gag aac ctc aaa tta atg atg aac ctg ctg cga gac aaa agt cgc aac       1239
Glu Asn Leu Lys Leu Met Met Asn Leu Leu Arg Asp Lys Ser Arg Asn           
    255                 260                 265                           

atc cag ttt gag gcc ttt cac gtt ttt aag gtg ttt gta gcc aat cct       1287
Ile Gln Phe Glu Ala Phe His Val Phe Lys Val Phe Val Ala Asn Pro           
270                 275                 280                 285           

aac aag acg cag ccc atc cta gac atc ctc ctc aag aac cag gcc aaa       1335
Asn Lys Thr Gln Pro Ile Leu Asp Ile Leu Leu Lys Asn Gln Ala Lys           
                290                 295                 300               

ctc ata gag ttc ctc agc aag ttt cag aac gac agg acg gag gat gag       1383
Leu Ile Glu Phe Leu Ser Lys Phe Gln Asn Asp Arg Thr Glu Asp Glu           
            305                 310                 315                   

cag ttt aac gac gag aag acc tat tta gtt aaa cag atc agg gat ttg       1431
Gln Phe Asn Asp Glu Lys Thr Tyr Leu Val Lys Gln Ile Arg Asp Leu           
        320                 325                 330                       

aag aga cca gct cag caa gaa gct taa tctccaataa acatctatgt             1478
Lys Arg Pro Ala Gln Gln Glu Ala                                           
    335                 340                                               

taaatccaaa ttcagcattt gctgttagct attcagcatc aggcactctt attgattcat     1538

gaggaacatt actgctaatc tgctgttaag tgaacggttt ttcattttac ccttttgttt     1598

ttcagtccag gttggagatc gtagctgctg ctgcttgcac actagggcac atgtgggctt     1658

tctcttgatc tttgtgtcat ttcagaattc aaagactgtg ctacgggagt tctgaacatg     1718

gctgggttca tgaaggcaaa tgtatggatg agagtgtggt ttaggaaaga gggcactgat     1778

atcagattag acctatgtgt ttgcacccat ctttgttggc gatctgagtg cagtgtggca     1838

agtgcacacc tggcatccct gcgtcagatc gcgcaccttc aggtcgcgca ccttcgctga     1898

aggaagatga cgcagagctt tatctgaaat cagaggggag ctatccaaaa tgggagtttg     1958

ggggcagcta aagttgacat gcgaataaat tgatactgaa acttagcaac ttcttaaaag     2018

tgtaaagaag cctcataaga tcataaggaa aatgtatata tgcttttcac agctttctag     2078

aattttttga catttgattt tcttgagact tgtaaacctg gatatgttga agggtatttg     2138

ttaattttac ttttcaaaga tactttaaaa cagtagagct agcaatgaca ccttgcattt     2198

catttcaaca ctgcttcaag gtttcttttg tatataattc ttagaatgct catttctttt     2258

aaatggttta atttgtacag cagaggaatg ttattgtagt agtatgtaac tattacctaa     2318

tactgagttt ttgcaaaaaa caatgaatgc tcatatgtaa ttgaaatact tcagatcaca     2378

tgaaaatgct gatttaacat ttaagtatca cagcattaaa agaaaaagaa agtaaaccag     2438

tcctttgtat tcagttacct aatggggtgc catcaataag ctgcgataca gccctggagc     2498

tcagtcagcc acaccttcct gcatcctatt ggccttattc attttaaatg agttaatgaa     2558

tctgccagat ctgtgaatga tagagattat gctaaattaa tgctgattct ttgtgtgtgt     2618

gggaaatctc tgtagagcac cttttctttc ttagactaag taacccagta caatagttgt     2678

gaactgaata attaaaactt tggcttctct taggaaaaga cgacttccta gtcataggtg     2738

tcctatgggg aaatttattt tttttaatgt cctgttcctt aatgctgcaa attatcagta     2798

tttataaagt aactgatttt gcaccacttt tttgttactg tgaccacggc agaacaatgt     2858

cttctagact atatctatgt aaagttatta gaatggtatc tgttcatttt agtgatatga     2918

agatcacaac taacaactga caaatcagag tttgccagtt caaattcagc atggctgcag     2978

ctgattaaga aattgatatg attattcttt gctagcctct cttactaatg gaattatata     3038

ctggccagta aaatgggcct cccaattgct gtttcagcag gttttaaacc ttcaggaaca     3098

ccagttagga aaatagctcc agaaaatata gatatatttt atttttatta aaatggcagt     3158

ctacatcata attggcattt ctcaagactg tctttaccag aatctgtgtg aaataaggca     3218

atctagtctc cttgaaaaaa aaatctcttg gatgtttagg aaggaagact tggccgtgat     3278

gtggtgtcct ggctttgtgg tgtagtgctg tgtgtatgga gttagtgtaa aaacatggat     3338

tacaccaagt ggaagaaacg tcttcttgcc aagctcattc ttagaactta cacatctaga     3398

acagcttcca ctttggcagt gaggtcgtag ccttttaggt ggaagaagtg agggtgcagc     3458

gtgtcagaca caacattcat gttactctta cattggaatc tgaaggtagt tcagacttcg     3518

tgggttttgt ttttaagcaa aacaatgtga aaacatttaa gtttgaaatg ttgcatttga     3578

agttatgatc atttaatata ttcatattac caagactatt atactggaag tggtttttgt     3638

gttataaagg tttaatttta cataaggcag ttacttaatg tgatttttaa cccttaaaaa     3698

agtggagatg tatacatttg ttaacaatgc catgaaagca ttttctttct cctaaggaaa     3758

agtgaatttc ttatcagaat atctggctgg ccctgtaatt taaattaaaa taaaattttg     3818

gagaaacagc aaaaaaaaaa aaaaaaaa                                        3846


<210>  284
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Pro Phe Pro Phe Gly Lys Ser His Lys Ser Pro Ala Asp Ile Val 
1               5                   10                  15      


Lys Asn Leu Lys Glu Ser Met Ala Val Leu Glu Lys Gln Asp Ile Ser 
            20                  25                  30          


Asp Lys Lys Ala Glu Lys Ala Thr Glu Glu Val Ser Lys Asn Leu Val 
        35                  40                  45              


Ala Met Lys Glu Ile Leu Tyr Gly Thr Asn Glu Lys Glu Pro Gln Thr 
    50                  55                  60                  


Glu Ala Val Ala Gln Leu Ala Gln Glu Leu Tyr Asn Ser Gly Leu Leu 
65                  70                  75                  80  


Ser Thr Leu Val Ala Asp Leu Gln Leu Ile Asp Phe Glu Gly Lys Lys 
                85                  90                  95      


Asp Val Ala Gln Ile Phe Asn Asn Ile Leu Arg Arg Gln Ile Gly Thr 
            100                 105                 110         


Arg Thr Pro Thr Val Glu Tyr Ile Cys Thr Gln Gln Asn Ile Leu Phe 
        115                 120                 125             


Met Leu Leu Lys Gly Tyr Glu Ser Pro Glu Ile Ala Leu Asn Cys Gly 
    130                 135                 140                 


Ile Met Leu Arg Glu Cys Ile Arg His Glu Pro Leu Ala Lys Ile Ile 
145                 150                 155                 160 


Leu Trp Ser Glu Gln Phe Tyr Asp Phe Phe Arg Tyr Val Glu Met Ser 
                165                 170                 175     


Thr Phe Asp Ile Ala Ser Asp Ala Phe Ala Thr Phe Lys Asp Leu Leu 
            180                 185                 190         


Thr Arg His Lys Leu Leu Ser Ala Glu Phe Leu Glu Gln His Tyr Asp 
        195                 200                 205             


Arg Phe Phe Ser Glu Tyr Glu Lys Leu Leu His Ser Glu Asn Tyr Val 
    210                 215                 220                 


Thr Lys Arg Gln Ser Leu Lys Leu Leu Gly Glu Leu Leu Leu Asp Arg 
225                 230                 235                 240 


His Asn Phe Thr Ile Met Thr Lys Tyr Ile Ser Lys Pro Glu Asn Leu 
                245                 250                 255     


Lys Leu Met Met Asn Leu Leu Arg Asp Lys Ser Arg Asn Ile Gln Phe 
            260                 265                 270         


Glu Ala Phe His Val Phe Lys Val Phe Val Ala Asn Pro Asn Lys Thr 
        275                 280                 285             


Gln Pro Ile Leu Asp Ile Leu Leu Lys Asn Gln Ala Lys Leu Ile Glu 
    290                 295                 300                 


Phe Leu Ser Lys Phe Gln Asn Asp Arg Thr Glu Asp Glu Gln Phe Asn 
305                 310                 315                 320 


Asp Glu Lys Thr Tyr Leu Val Lys Gln Ile Arg Asp Leu Lys Arg Pro 
                325                 330                 335     


Ala Gln Gln Glu Ala 
            340     


<210>  285
<211>  3184
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (244)..(2721)

<400>  285
gcctgctgct ggccgggcgg gggacggggc cgggaccgga gccggagctg cggggcgcac       60

cggctagacg cgcgcgggat tctcggcggg cacgccccgc ggaccatgag cgtccccagc      120

tccgggagca gccgcggcgc gggcggtgcg aggccggccg cgcggcgcct ttgagcccca      180

gccggaggtc cagagatcct gagagcccga gcgcccagcg ccgcgccggg agagttgaga      240

att atg gct gca gga aaa ttt gca agc ctt ccc aga aac atg ccg gtg        288
    Met Ala Ala Gly Lys Phe Ala Ser Leu Pro Arg Asn Met Pro Val           
    1               5                   10                  15            

aat cac cag ttc ccc ctg gcc tca tcc atg gac ctt ctg agc agc agg        336
Asn His Gln Phe Pro Leu Ala Ser Ser Met Asp Leu Leu Ser Ser Arg           
                20                  25                  30                

tcc cct ctc gct gag cat cgc cca gat gcc tat caa gat gtg tct ata        384
Ser Pro Leu Ala Glu His Arg Pro Asp Ala Tyr Gln Asp Val Ser Ile           
            35                  40                  45                    

cat ggc acc ctt cca cgg aag aaa aaa ggt cct cct ccc ata agg tcc        432
His Gly Thr Leu Pro Arg Lys Lys Lys Gly Pro Pro Pro Ile Arg Ser           
        50                  55                  60                        

tgt gat gac ttc agt cac atg ggc acc ctc ccc cac tcc aaa tcc cca        480
Cys Asp Asp Phe Ser His Met Gly Thr Leu Pro His Ser Lys Ser Pro           
    65                  70                  75                            

cgg cag aac tcg cct gtg acc cag gat ggc atc cag gag agc cca tgg        528
Arg Gln Asn Ser Pro Val Thr Gln Asp Gly Ile Gln Glu Ser Pro Trp           
80                  85                  90                  95            

cag gac cgg cac ggc gaa acc ttc acc ttc agg gat cca cat ctt ctg        576
Gln Asp Arg His Gly Glu Thr Phe Thr Phe Arg Asp Pro His Leu Leu           
                100                 105                 110               

gac cca act gtg gaa tat gtg aag ttc tcc aag gag agg cac atc atg        624
Asp Pro Thr Val Glu Tyr Val Lys Phe Ser Lys Glu Arg His Ile Met           
            115                 120                 125                   

gac agg acc ccc gag aaa ctg aag aag gag ctg gag gag gag ctg ctc        672
Asp Arg Thr Pro Glu Lys Leu Lys Lys Glu Leu Glu Glu Glu Leu Leu           
        130                 135                 140                       

ctg agc agc gag gac ctg cgc agc cat gcc tgg tac cac ggc cgc atc        720
Leu Ser Ser Glu Asp Leu Arg Ser His Ala Trp Tyr His Gly Arg Ile           
    145                 150                 155                           

ccc cga cag gtg tct gaa aac ctt gtg cag cga gat ggt gac ttc cta        768
Pro Arg Gln Val Ser Glu Asn Leu Val Gln Arg Asp Gly Asp Phe Leu           
160                 165                 170                 175           

gtt cgt gac tct ctg tcc agc cct ggg aac ttt gtc ctg acc tgt cag        816
Val Arg Asp Ser Leu Ser Ser Pro Gly Asn Phe Val Leu Thr Cys Gln           
                180                 185                 190               

tgg aag aac ctc gct cag cac ttc aaa atc aac cgg aca gtt ctg cga        864
Trp Lys Asn Leu Ala Gln His Phe Lys Ile Asn Arg Thr Val Leu Arg           
            195                 200                 205                   

ctc agc gag gcc tac agc cgc gtg cag tac cag ttc gag atg gag agc        912
Leu Ser Glu Ala Tyr Ser Arg Val Gln Tyr Gln Phe Glu Met Glu Ser           
        210                 215                 220                       

ttc gac tcc atc ccc ggc ctg gtg cgc tgc tac gtg ggc aac cgc cgg        960
Phe Asp Ser Ile Pro Gly Leu Val Arg Cys Tyr Val Gly Asn Arg Arg           
    225                 230                 235                           

ccc atc tcc cag cag agt ggc gcc atc atc ttc cag ccc atc aac agg       1008
Pro Ile Ser Gln Gln Ser Gly Ala Ile Ile Phe Gln Pro Ile Asn Arg           
240                 245                 250                 255           

acg gtg cct ctg cgg tgc ctg gag gag cat tat ggc acc tcc cca ggc       1056
Thr Val Pro Leu Arg Cys Leu Glu Glu His Tyr Gly Thr Ser Pro Gly           
                260                 265                 270               

cag gcc cgg gag ggc agc ctc acc aag gga agg ccg gat gtg gcc aag       1104
Gln Ala Arg Glu Gly Ser Leu Thr Lys Gly Arg Pro Asp Val Ala Lys           
            275                 280                 285                   

agg ctg agc ctc acc atg ggt ggc gtc cag gcc cga gag cag aat ttg       1152
Arg Leu Ser Leu Thr Met Gly Gly Val Gln Ala Arg Glu Gln Asn Leu           
        290                 295                 300                       

ccc agg gga aac ctc ctc aga aac aaa gaa aag agt ggt agc cag ccc       1200
Pro Arg Gly Asn Leu Leu Arg Asn Lys Glu Lys Ser Gly Ser Gln Pro           
    305                 310                 315                           

gcc tgc ctg gat cac atg cag gac aga aga gcc ttg tcc ctc aaa gcc       1248
Ala Cys Leu Asp His Met Gln Asp Arg Arg Ala Leu Ser Leu Lys Ala           
320                 325                 330                 335           

cac cag tca gag agc tac ctg ccg att ggc tgc aag ctg cca cct cag       1296
His Gln Ser Glu Ser Tyr Leu Pro Ile Gly Cys Lys Leu Pro Pro Gln           
                340                 345                 350               

tcc tcg ggt gtg gac aca agc ccc tgc cca aac tca cct gtg ttc agg       1344
Ser Ser Gly Val Asp Thr Ser Pro Cys Pro Asn Ser Pro Val Phe Arg           
            355                 360                 365                   

acg gga agc gag cct gcc ctg agc cca gca gtg gtt cgg agg gtc tcc       1392
Thr Gly Ser Glu Pro Ala Leu Ser Pro Ala Val Val Arg Arg Val Ser           
        370                 375                 380                       

tca gac gcc agg gct ggg gag gcg ctg agg gga tca gac agt caa ctg       1440
Ser Asp Ala Arg Ala Gly Glu Ala Leu Arg Gly Ser Asp Ser Gln Leu           
    385                 390                 395                           

tgc cct aag ccc ccg cct aag ccc tgc aag gtg ccg ttc ctc aag gtt       1488
Cys Pro Lys Pro Pro Pro Lys Pro Cys Lys Val Pro Phe Leu Lys Val           
400                 405                 410                 415           

ccc tcg tct ccc tct gcc tgg ctc aac tca gag gcc aac tac tgt gaa       1536
Pro Ser Ser Pro Ser Ala Trp Leu Asn Ser Glu Ala Asn Tyr Cys Glu           
                420                 425                 430               

ctg aac cca gcg ttt gcc aca ggc tgc ggc agg gga gca aag cta ccc       1584
Leu Asn Pro Ala Phe Ala Thr Gly Cys Gly Arg Gly Ala Lys Leu Pro           
            435                 440                 445                   

tca tgt gcc cag gga agc cac aca gaa ctg ctc aca gcc aag cag aat       1632
Ser Cys Ala Gln Gly Ser His Thr Glu Leu Leu Thr Ala Lys Gln Asn           
        450                 455                 460                       

gag gcg cca ggt ccc cgg aac tct ggc gtc aac tac ttg atc ctt gat       1680
Glu Ala Pro Gly Pro Arg Asn Ser Gly Val Asn Tyr Leu Ile Leu Asp           
    465                 470                 475                           

gat gat gac agg gaa aga cct tgg gaa cct gcg gca gct cag atg gag       1728
Asp Asp Asp Arg Glu Arg Pro Trp Glu Pro Ala Ala Ala Gln Met Glu           
480                 485                 490                 495           

aag ggg cag tgg gac aag ggc gag ttt gtg acg ccc ctc ctg gag act       1776
Lys Gly Gln Trp Asp Lys Gly Glu Phe Val Thr Pro Leu Leu Glu Thr           
                500                 505                 510               

gtc tcc tcc ttc agg ccc aac gag ttt gag tca aag ttc ctt ccc cct       1824
Val Ser Ser Phe Arg Pro Asn Glu Phe Glu Ser Lys Phe Leu Pro Pro           
            515                 520                 525                   

gag aat aag ccc ctg gaa aca gca atg ttg aaa cgt gca aaa gaa ctg       1872
Glu Asn Lys Pro Leu Glu Thr Ala Met Leu Lys Arg Ala Lys Glu Leu           
        530                 535                 540                       

ttc acc aac aac gac ccc aag gtc atc gcc cag cac gta ctg agc atg       1920
Phe Thr Asn Asn Asp Pro Lys Val Ile Ala Gln His Val Leu Ser Met           
    545                 550                 555                           

gac tgc agg gtt gct agg ata ctt gga gtc tct gaa gag atg agg agg       1968
Asp Cys Arg Val Ala Arg Ile Leu Gly Val Ser Glu Glu Met Arg Arg           
560                 565                 570                 575           

aac atg ggg gtg agc tca ggc ctg gaa ctc att acc ttg cct cac gga       2016
Asn Met Gly Val Ser Ser Gly Leu Glu Leu Ile Thr Leu Pro His Gly           
                580                 585                 590               

cac cag ctg cgc ctg gac ata att gaa aga cac aac aca atg gcc atc       2064
His Gln Leu Arg Leu Asp Ile Ile Glu Arg His Asn Thr Met Ala Ile           
            595                 600                 605                   

ggc att gca gtg gac att ctg gga tgc acg ggc act ttg gag gac cga       2112
Gly Ile Ala Val Asp Ile Leu Gly Cys Thr Gly Thr Leu Glu Asp Arg           
        610                 615                 620                       

gcg gcc act ctg agt aag atc atc cag gtg gcg gtg gaa ctg aag gat       2160
Ala Ala Thr Leu Ser Lys Ile Ile Gln Val Ala Val Glu Leu Lys Asp           
    625                 630                 635                           

tcc atg ggg gac ctc tat tcc ttc tca gct ctc atg aaa gcc ctg gaa       2208
Ser Met Gly Asp Leu Tyr Ser Phe Ser Ala Leu Met Lys Ala Leu Glu           
640                 645                 650                 655           

atg cca cag atc aca agg tta gaa aag acg tgg act gct ctg cgg cac       2256
Met Pro Gln Ile Thr Arg Leu Glu Lys Thr Trp Thr Ala Leu Arg His           
                660                 665                 670               

cag tac acc caa act gcc att ctc tat gag aaa cag ctg aag ccc ttc       2304
Gln Tyr Thr Gln Thr Ala Ile Leu Tyr Glu Lys Gln Leu Lys Pro Phe           
            675                 680                 685                   

agc aaa ctc ctg cat gaa ggc aga gag tcc aca tgt gtt ccc cca aac       2352
Ser Lys Leu Leu His Glu Gly Arg Glu Ser Thr Cys Val Pro Pro Asn           
        690                 695                 700                       

aat gta tca gtc cca ctg ctg atg ccg ctt gtg acg tta atg gag cgc       2400
Asn Val Ser Val Pro Leu Leu Met Pro Leu Val Thr Leu Met Glu Arg           
    705                 710                 715                           

cag gct gtg act ttt gaa gga acc gac atg tgg gaa aaa aac gac cag       2448
Gln Ala Val Thr Phe Glu Gly Thr Asp Met Trp Glu Lys Asn Asp Gln           
720                 725                 730                 735           

agc tgt gaa atc atg ctg aac cat ttg gca aca gcg cga ttc atg gcc       2496
Ser Cys Glu Ile Met Leu Asn His Leu Ala Thr Ala Arg Phe Met Ala           
                740                 745                 750               

gag gct gca gac agc tac cgg atg aat gct gag agg atc ctg gca ggt       2544
Glu Ala Ala Asp Ser Tyr Arg Met Asn Ala Glu Arg Ile Leu Ala Gly           
            755                 760                 765                   

ttt caa cca gat gaa gaa atg aat gaa atc tgc aag act gaa ttt caa       2592
Phe Gln Pro Asp Glu Glu Met Asn Glu Ile Cys Lys Thr Glu Phe Gln           
        770                 775                 780                       

atg cga ttg cta tgg ggc agc aaa ggt gca caa gtc aat cag aca gag       2640
Met Arg Leu Leu Trp Gly Ser Lys Gly Ala Gln Val Asn Gln Thr Glu           
    785                 790                 795                           

aga tat gag aaa ttc aac cag att tta act gcc ctc tcg cgt aaa ttg       2688
Arg Tyr Glu Lys Phe Asn Gln Ile Leu Thr Ala Leu Ser Arg Lys Leu           
800                 805                 810                 815           

gaa cct cct cct gta aag cag gca gag ctt tga taactctcca gagaaccttt     2741
Glu Pro Pro Pro Val Lys Gln Ala Glu Leu                                   
                820                 825                                   

agaatatctt ttcaagtttc cccagcttca tctttgggaa agcttactgt ttttgataaa     2801

gtaataatgt gcaaatctga caatatacaa gcttttagta tccacaggat attaaacgtg     2861

taaattgcac agagcacact tatttatgaa ttgtctaaag ttactactga ttttaaaatg     2921

aataatttat tattaaggta actactgcta atgttgatca gcaaatttaa gagaagacct     2981

agctatgttg gctggttgct ttctattatc atggtatttg accattttag ttttaattcc     3041

atgtcagata agtgtaaata gaagagttta aaagcatgaa acatttcaga aggtatcagt     3101

tatatgatat tctttaaaca aatatgaaaa atgtaaatac tcatgaatga aaatacatct     3161

ttttgtgaaa aaaaaaaaaa aaa                                             3184


<210>  286
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  286

Met Ala Ala Gly Lys Phe Ala Ser Leu Pro Arg Asn Met Pro Val Asn 
1               5                   10                  15      


His Gln Phe Pro Leu Ala Ser Ser Met Asp Leu Leu Ser Ser Arg Ser 
            20                  25                  30          


Pro Leu Ala Glu His Arg Pro Asp Ala Tyr Gln Asp Val Ser Ile His 
        35                  40                  45              


Gly Thr Leu Pro Arg Lys Lys Lys Gly Pro Pro Pro Ile Arg Ser Cys 
    50                  55                  60                  


Asp Asp Phe Ser His Met Gly Thr Leu Pro His Ser Lys Ser Pro Arg 
65                  70                  75                  80  


Gln Asn Ser Pro Val Thr Gln Asp Gly Ile Gln Glu Ser Pro Trp Gln 
                85                  90                  95      


Asp Arg His Gly Glu Thr Phe Thr Phe Arg Asp Pro His Leu Leu Asp 
            100                 105                 110         


Pro Thr Val Glu Tyr Val Lys Phe Ser Lys Glu Arg His Ile Met Asp 
        115                 120                 125             


Arg Thr Pro Glu Lys Leu Lys Lys Glu Leu Glu Glu Glu Leu Leu Leu 
    130                 135                 140                 


Ser Ser Glu Asp Leu Arg Ser His Ala Trp Tyr His Gly Arg Ile Pro 
145                 150                 155                 160 


Arg Gln Val Ser Glu Asn Leu Val Gln Arg Asp Gly Asp Phe Leu Val 
                165                 170                 175     


Arg Asp Ser Leu Ser Ser Pro Gly Asn Phe Val Leu Thr Cys Gln Trp 
            180                 185                 190         


Lys Asn Leu Ala Gln His Phe Lys Ile Asn Arg Thr Val Leu Arg Leu 
        195                 200                 205             


Ser Glu Ala Tyr Ser Arg Val Gln Tyr Gln Phe Glu Met Glu Ser Phe 
    210                 215                 220                 


Asp Ser Ile Pro Gly Leu Val Arg Cys Tyr Val Gly Asn Arg Arg Pro 
225                 230                 235                 240 


Ile Ser Gln Gln Ser Gly Ala Ile Ile Phe Gln Pro Ile Asn Arg Thr 
                245                 250                 255     


Val Pro Leu Arg Cys Leu Glu Glu His Tyr Gly Thr Ser Pro Gly Gln 
            260                 265                 270         


Ala Arg Glu Gly Ser Leu Thr Lys Gly Arg Pro Asp Val Ala Lys Arg 
        275                 280                 285             


Leu Ser Leu Thr Met Gly Gly Val Gln Ala Arg Glu Gln Asn Leu Pro 
    290                 295                 300                 


Arg Gly Asn Leu Leu Arg Asn Lys Glu Lys Ser Gly Ser Gln Pro Ala 
305                 310                 315                 320 


Cys Leu Asp His Met Gln Asp Arg Arg Ala Leu Ser Leu Lys Ala His 
                325                 330                 335     


Gln Ser Glu Ser Tyr Leu Pro Ile Gly Cys Lys Leu Pro Pro Gln Ser 
            340                 345                 350         


Ser Gly Val Asp Thr Ser Pro Cys Pro Asn Ser Pro Val Phe Arg Thr 
        355                 360                 365             


Gly Ser Glu Pro Ala Leu Ser Pro Ala Val Val Arg Arg Val Ser Ser 
    370                 375                 380                 


Asp Ala Arg Ala Gly Glu Ala Leu Arg Gly Ser Asp Ser Gln Leu Cys 
385                 390                 395                 400 


Pro Lys Pro Pro Pro Lys Pro Cys Lys Val Pro Phe Leu Lys Val Pro 
                405                 410                 415     


Ser Ser Pro Ser Ala Trp Leu Asn Ser Glu Ala Asn Tyr Cys Glu Leu 
            420                 425                 430         


Asn Pro Ala Phe Ala Thr Gly Cys Gly Arg Gly Ala Lys Leu Pro Ser 
        435                 440                 445             


Cys Ala Gln Gly Ser His Thr Glu Leu Leu Thr Ala Lys Gln Asn Glu 
    450                 455                 460                 


Ala Pro Gly Pro Arg Asn Ser Gly Val Asn Tyr Leu Ile Leu Asp Asp 
465                 470                 475                 480 


Asp Asp Arg Glu Arg Pro Trp Glu Pro Ala Ala Ala Gln Met Glu Lys 
                485                 490                 495     


Gly Gln Trp Asp Lys Gly Glu Phe Val Thr Pro Leu Leu Glu Thr Val 
            500                 505                 510         


Ser Ser Phe Arg Pro Asn Glu Phe Glu Ser Lys Phe Leu Pro Pro Glu 
        515                 520                 525             


Asn Lys Pro Leu Glu Thr Ala Met Leu Lys Arg Ala Lys Glu Leu Phe 
    530                 535                 540                 


Thr Asn Asn Asp Pro Lys Val Ile Ala Gln His Val Leu Ser Met Asp 
545                 550                 555                 560 


Cys Arg Val Ala Arg Ile Leu Gly Val Ser Glu Glu Met Arg Arg Asn 
                565                 570                 575     


Met Gly Val Ser Ser Gly Leu Glu Leu Ile Thr Leu Pro His Gly His 
            580                 585                 590         


Gln Leu Arg Leu Asp Ile Ile Glu Arg His Asn Thr Met Ala Ile Gly 
        595                 600                 605             


Ile Ala Val Asp Ile Leu Gly Cys Thr Gly Thr Leu Glu Asp Arg Ala 
    610                 615                 620                 


Ala Thr Leu Ser Lys Ile Ile Gln Val Ala Val Glu Leu Lys Asp Ser 
625                 630                 635                 640 


Met Gly Asp Leu Tyr Ser Phe Ser Ala Leu Met Lys Ala Leu Glu Met 
                645                 650                 655     


Pro Gln Ile Thr Arg Leu Glu Lys Thr Trp Thr Ala Leu Arg His Gln 
            660                 665                 670         


Tyr Thr Gln Thr Ala Ile Leu Tyr Glu Lys Gln Leu Lys Pro Phe Ser 
        675                 680                 685             


Lys Leu Leu His Glu Gly Arg Glu Ser Thr Cys Val Pro Pro Asn Asn 
    690                 695                 700                 


Val Ser Val Pro Leu Leu Met Pro Leu Val Thr Leu Met Glu Arg Gln 
705                 710                 715                 720 


Ala Val Thr Phe Glu Gly Thr Asp Met Trp Glu Lys Asn Asp Gln Ser 
                725                 730                 735     


Cys Glu Ile Met Leu Asn His Leu Ala Thr Ala Arg Phe Met Ala Glu 
            740                 745                 750         


Ala Ala Asp Ser Tyr Arg Met Asn Ala Glu Arg Ile Leu Ala Gly Phe 
        755                 760                 765             


Gln Pro Asp Glu Glu Met Asn Glu Ile Cys Lys Thr Glu Phe Gln Met 
    770                 775                 780                 


Arg Leu Leu Trp Gly Ser Lys Gly Ala Gln Val Asn Gln Thr Glu Arg 
785                 790                 795                 800 


Tyr Glu Lys Phe Asn Gln Ile Leu Thr Ala Leu Ser Arg Lys Leu Glu 
                805                 810                 815     


Pro Pro Pro Val Lys Gln Ala Glu Leu 
            820                 825 


<210>  287
<211>  978
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (95)..(649)

<400>  287
actatgccgt cggcgagcgt gatagccaac aggaaccggg agcggggtcc cgggactggg       60

aagaaacggc ggccgggagg gggctccggg gacc atg ggg ctc ctg acc att ctg      115
                                      Met Gly Leu Leu Thr Ile Leu         
                                      1               5                   

aag aag atg aag cag aaa gag cgg gag ctg cga ctg ctc atg ctt ggc        163
Lys Lys Met Lys Gln Lys Glu Arg Glu Leu Arg Leu Leu Met Leu Gly           
        10                  15                  20                        

ctg gac aat gct gga aag aca acc atc ctg aag aag ttc aat ggg gag        211
Leu Asp Asn Ala Gly Lys Thr Thr Ile Leu Lys Lys Phe Asn Gly Glu           
    25                  30                  35                            

gac atc gac acc atc tcc cca acg ctg ggc ttc aac atc aag acc ctg        259
Asp Ile Asp Thr Ile Ser Pro Thr Leu Gly Phe Asn Ile Lys Thr Leu           
40                  45                  50                  55            

gag cac cga gga ttc aag ctg aac atc tgg gat gtg ggt ggc cag aag        307
Glu His Arg Gly Phe Lys Leu Asn Ile Trp Asp Val Gly Gly Gln Lys           
                60                  65                  70                

tcc ctg cgg tcc tac tgg cgg aac tac ttt gag agc acc gat ggc ctc        355
Ser Leu Arg Ser Tyr Trp Arg Asn Tyr Phe Glu Ser Thr Asp Gly Leu           
            75                  80                  85                    

atc tgg gta gtg gac agc gca gac cgc cag cgc atg cag gac tgc cag        403
Ile Trp Val Val Asp Ser Ala Asp Arg Gln Arg Met Gln Asp Cys Gln           
        90                  95                  100                       

cgg gag ctc cag agc ctg ctg gtg gag gag cgc ctg gcc gga gca acc        451
Arg Glu Leu Gln Ser Leu Leu Val Glu Glu Arg Leu Ala Gly Ala Thr           
    105                 110                 115                           

ctc ctc atc ttt gct aat aag cag gac ctg cct gga gca ctg tcc tct        499
Leu Leu Ile Phe Ala Asn Lys Gln Asp Leu Pro Gly Ala Leu Ser Ser           
120                 125                 130                 135           

aac gcc atc cgc gag gtc ctg gag ctg gac tcc atc cgc agc cac cac        547
Asn Ala Ile Arg Glu Val Leu Glu Leu Asp Ser Ile Arg Ser His His           
                140                 145                 150               

tgg tgc atc cag ggc tgc agc gcc gtc acc ggg gag aac ctg ctg ccg        595
Trp Cys Ile Gln Gly Cys Ser Ala Val Thr Gly Glu Asn Leu Leu Pro           
            155                 160                 165                   

ggc atc gac tgg ctc ctg gat gac att tcc agc cgc att ttc aca gct        643
Gly Ile Asp Trp Leu Leu Asp Asp Ile Ser Ser Arg Ile Phe Thr Ala           
        170                 175                 180                       

gac tga accactccag atgcccccca cctagcagtc caggtccctc aaccttcacc         699
Asp                                                                       
                                                                          

aaacactacc catggggggt tgggagtcag ccggccaaac taacactccc cctcctccac      759

cccagcctgc tgctgctact gctgcccgct gctgctctgt ggccacccgg ctcccatggc      819

gggagggctg tgccctggct gtctctctgg ctcctgacct ggcctttggc taccatacca      879

agaagagagg gctgggcggg gaggagctgc tactgctgct accgaggctg tgggcctcat      939

ccttcactca gttgtgaaat aaaccgctcc ttgccccga                             978


<210>  288
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  288

Met Gly Leu Leu Thr Ile Leu Lys Lys Met Lys Gln Lys Glu Arg Glu 
1               5                   10                  15      


Leu Arg Leu Leu Met Leu Gly Leu Asp Asn Ala Gly Lys Thr Thr Ile 
            20                  25                  30          


Leu Lys Lys Phe Asn Gly Glu Asp Ile Asp Thr Ile Ser Pro Thr Leu 
        35                  40                  45              


Gly Phe Asn Ile Lys Thr Leu Glu His Arg Gly Phe Lys Leu Asn Ile 
    50                  55                  60                  


Trp Asp Val Gly Gly Gln Lys Ser Leu Arg Ser Tyr Trp Arg Asn Tyr 
65                  70                  75                  80  


Phe Glu Ser Thr Asp Gly Leu Ile Trp Val Val Asp Ser Ala Asp Arg 
                85                  90                  95      


Gln Arg Met Gln Asp Cys Gln Arg Glu Leu Gln Ser Leu Leu Val Glu 
            100                 105                 110         


Glu Arg Leu Ala Gly Ala Thr Leu Leu Ile Phe Ala Asn Lys Gln Asp 
        115                 120                 125             


Leu Pro Gly Ala Leu Ser Ser Asn Ala Ile Arg Glu Val Leu Glu Leu 
    130                 135                 140                 


Asp Ser Ile Arg Ser His His Trp Cys Ile Gln Gly Cys Ser Ala Val 
145                 150                 155                 160 


Thr Gly Glu Asn Leu Leu Pro Gly Ile Asp Trp Leu Leu Asp Asp Ile 
                165                 170                 175     


Ser Ser Arg Ile Phe Thr Ala Asp 
            180                 


<210>  289
<211>  1951
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (46)..(1335)

<400>  289
ggaagttgcc ggcggccgcg cggcctcccg ggcgggccta cagcc atg tcc cgg gac       57
                                                  Met Ser Arg Asp         
                                                  1                       

ccg ggg tcg ggc ggc tgg gag gag gcc ccg cgc gca gct gcc gcg ctc        105
Pro Gly Ser Gly Gly Trp Glu Glu Ala Pro Arg Ala Ala Ala Ala Leu           
5                   10                  15                  20            

tgc acc ctg tac cac gag gcc gga cag cgg ctg cgc cgc ctg cag gac        153
Cys Thr Leu Tyr His Glu Ala Gly Gln Arg Leu Arg Arg Leu Gln Asp           
                25                  30                  35                

cag ctc gct gcc cgc gac gcc ctc atc gct cgc ctc cgc gcc cgc ctg        201
Gln Leu Ala Ala Arg Asp Ala Leu Ile Ala Arg Leu Arg Ala Arg Leu           
            40                  45                  50                    

gcc gcg ctg gag ggg gac gcc gcg ccg tcc cta gtg gac gcg ctg ctg        249
Ala Ala Leu Glu Gly Asp Ala Ala Pro Ser Leu Val Asp Ala Leu Leu           
        55                  60                  65                        

gag cag gtt gcg cgc ttc cgg gag cag ctg cga agg cag gag ggc ggc        297
Glu Gln Val Ala Arg Phe Arg Glu Gln Leu Arg Arg Gln Glu Gly Gly           
    70                  75                  80                            

gcc gcc gag gcc cag atg cgc cag gaa att gag agg ctg act gag cga        345
Ala Ala Glu Ala Gln Met Arg Gln Glu Ile Glu Arg Leu Thr Glu Arg           
85                  90                  95                  100           

cta gaa gaa aaa gag agg gag atg cag cag ctg ctg agc cag ccc caa        393
Leu Glu Glu Lys Glu Arg Glu Met Gln Gln Leu Leu Ser Gln Pro Gln           
                105                 110                 115               

cac gag cga gag aag gaa gtc gtc ctg cta cgg agg agc atg gca gaa        441
His Glu Arg Glu Lys Glu Val Val Leu Leu Arg Arg Ser Met Ala Glu           
            120                 125                 130                   

ggg gag cgc gcc cgg gcc gcc agt gac gtc ctg tgc cgc tcc ttg gcc        489
Gly Glu Arg Ala Arg Ala Ala Ser Asp Val Leu Cys Arg Ser Leu Ala           
        135                 140                 145                       

aac gag acc cat cag ctg cgg agg acg ctg acc gcc acc gcc cac atg        537
Asn Glu Thr His Gln Leu Arg Arg Thr Leu Thr Ala Thr Ala His Met           
    150                 155                 160                           

tgt cag cat ctg gcc aag tgt ctg gat gaa cga cag cat gca caa agg        585
Cys Gln His Leu Ala Lys Cys Leu Asp Glu Arg Gln His Ala Gln Arg           
165                 170                 175                 180           

aat gtg ggg gag aga agt cct gac cag tcg gaa cac aca gat ggg cac        633
Asn Val Gly Glu Arg Ser Pro Asp Gln Ser Glu His Thr Asp Gly His           
                185                 190                 195               

acc tct gtc cag agt gtt att gag aag ttg cag gaa gaa aat cga ctg        681
Thr Ser Val Gln Ser Val Ile Glu Lys Leu Gln Glu Glu Asn Arg Leu           
            200                 205                 210                   

tta aaa cag aag gtg act cac gtt gaa gac ctc aat gcc aag tgg cag        729
Leu Lys Gln Lys Val Thr His Val Glu Asp Leu Asn Ala Lys Trp Gln           
        215                 220                 225                       

cgc tac aac gcc agc agg gac gaa tac gtg agg ggg ctc cat gcg cag        777
Arg Tyr Asn Ala Ser Arg Asp Glu Tyr Val Arg Gly Leu His Ala Gln           
    230                 235                 240                           

ctc agg ggg ctg cag atc ccc cac gag ccc gag ctg atg agg aag gag        825
Leu Arg Gly Leu Gln Ile Pro His Glu Pro Glu Leu Met Arg Lys Glu           
245                 250                 255                 260           

atc tcc cgg ctc aac aga cag ttg gaa gag aaa ata aat gac tgt gcc        873
Ile Ser Arg Leu Asn Arg Gln Leu Glu Glu Lys Ile Asn Asp Cys Ala           
                265                 270                 275               

gaa gtg aag cag gag ctg gcg gcc tcc agg acg gcc cgg gat gct gcg        921
Glu Val Lys Gln Glu Leu Ala Ala Ser Arg Thr Ala Arg Asp Ala Ala           
            280                 285                 290                   

ttg gag cgg gtg cag atg ctg gaa cag cag att ctc gct tac aag gat        969
Leu Glu Arg Val Gln Met Leu Glu Gln Gln Ile Leu Ala Tyr Lys Asp           
        295                 300                 305                       

gac ttc atg tca gaa agg gcc gat cgg gaa cgg gct caa agt agg att       1017
Asp Phe Met Ser Glu Arg Ala Asp Arg Glu Arg Ala Gln Ser Arg Ile           
    310                 315                 320                           

caa gaa ctg gag gaa aag gtc gcc tct ttg ctg cac cag gtg tcc tgg       1065
Gln Glu Leu Glu Glu Lys Val Ala Ser Leu Leu His Gln Val Ser Trp           
325                 330                 335                 340           

aga cag gat tct cga gag cca gac gcc ggc cgg att cac gct ggg agc       1113
Arg Gln Asp Ser Arg Glu Pro Asp Ala Gly Arg Ile His Ala Gly Ser           
                345                 350                 355               

aaa act gcc aag tat ttg gcc gcc gac gca tta gag ctt atg gtg cct       1161
Lys Thr Ala Lys Tyr Leu Ala Ala Asp Ala Leu Glu Leu Met Val Pro           
            360                 365                 370                   

ggt ggc tgg agg cct ggg act ggg tcc cag cag cca gaa ccc cct gca       1209
Gly Gly Trp Arg Pro Gly Thr Gly Ser Gln Gln Pro Glu Pro Pro Ala           
        375                 380                 385                       

gag ggc ggg cat cct ggc gcg gtc cag aga ggc cag ggg gac ctt cag       1257
Glu Gly Gly His Pro Gly Ala Val Gln Arg Gly Gln Gly Asp Leu Gln           
    390                 395                 400                           

tgc cct cac tgc ctg cag tgc ttc agt gac gag caa ggg gaa gag ctc       1305
Cys Pro His Cys Leu Gln Cys Phe Ser Asp Glu Gln Gly Glu Glu Leu           
405                 410                 415                 420           

ctc agg cat gtg gcc gag tgc tgc cag tga ccgagactca cccgtgccct         1355
Leu Arg His Val Ala Glu Cys Cys Gln                                       
                425                                                       

tgcggcctcc tggcccggtg cagctgccct cagggacagg gtgggtgctc tcagatgcca     1415

tgggttgagc tctactgaga gccaaggccc ctagaatagt tgcggggcac tctgatcgtt     1475

cactttggtc cctttggcta tggaacaggc tgggtcacag ggaactgcca gtgaggctgg     1535

aggctggagg tggagatggg gtcaggaaca tctggcagag ggaggtccca gtctgtgtct     1595

ccatcaggct taagccagag ctatctggtg ctggtgtgcc agcccctccc ccagcctgcc     1655

tagaaagggg tggctgcctg agggagtcac ttgtatggtc cccagggtgg gagccccatc     1715

ctgttctatg gaataaagcg tcgcctctct gcctcgaacc agtcaaatgg agtattgcgg     1775

ctgcacgtca cactagggtg gccacccccg ccattgcgag ccacatgtct gcactgagaa     1835

actgcatttc agtagcattt gtcatccagc cggaagttaa agcacactta ctttattcac     1895

ctatttttat aataaacgtt cttgctgctg tgactgcaaa aaaaaaaaaa aaaaaa         1951


<210>  290
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Ser Arg Asp Pro Gly Ser Gly Gly Trp Glu Glu Ala Pro Arg Ala 
1               5                   10                  15      


Ala Ala Ala Leu Cys Thr Leu Tyr His Glu Ala Gly Gln Arg Leu Arg 
            20                  25                  30          


Arg Leu Gln Asp Gln Leu Ala Ala Arg Asp Ala Leu Ile Ala Arg Leu 
        35                  40                  45              


Arg Ala Arg Leu Ala Ala Leu Glu Gly Asp Ala Ala Pro Ser Leu Val 
    50                  55                  60                  


Asp Ala Leu Leu Glu Gln Val Ala Arg Phe Arg Glu Gln Leu Arg Arg 
65                  70                  75                  80  


Gln Glu Gly Gly Ala Ala Glu Ala Gln Met Arg Gln Glu Ile Glu Arg 
                85                  90                  95      


Leu Thr Glu Arg Leu Glu Glu Lys Glu Arg Glu Met Gln Gln Leu Leu 
            100                 105                 110         


Ser Gln Pro Gln His Glu Arg Glu Lys Glu Val Val Leu Leu Arg Arg 
        115                 120                 125             


Ser Met Ala Glu Gly Glu Arg Ala Arg Ala Ala Ser Asp Val Leu Cys 
    130                 135                 140                 


Arg Ser Leu Ala Asn Glu Thr His Gln Leu Arg Arg Thr Leu Thr Ala 
145                 150                 155                 160 


Thr Ala His Met Cys Gln His Leu Ala Lys Cys Leu Asp Glu Arg Gln 
                165                 170                 175     


His Ala Gln Arg Asn Val Gly Glu Arg Ser Pro Asp Gln Ser Glu His 
            180                 185                 190         


Thr Asp Gly His Thr Ser Val Gln Ser Val Ile Glu Lys Leu Gln Glu 
        195                 200                 205             


Glu Asn Arg Leu Leu Lys Gln Lys Val Thr His Val Glu Asp Leu Asn 
    210                 215                 220                 


Ala Lys Trp Gln Arg Tyr Asn Ala Ser Arg Asp Glu Tyr Val Arg Gly 
225                 230                 235                 240 


Leu His Ala Gln Leu Arg Gly Leu Gln Ile Pro His Glu Pro Glu Leu 
                245                 250                 255     


Met Arg Lys Glu Ile Ser Arg Leu Asn Arg Gln Leu Glu Glu Lys Ile 
            260                 265                 270         


Asn Asp Cys Ala Glu Val Lys Gln Glu Leu Ala Ala Ser Arg Thr Ala 
        275                 280                 285             


Arg Asp Ala Ala Leu Glu Arg Val Gln Met Leu Glu Gln Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Lys Asp Asp Phe Met Ser Glu Arg Ala Asp Arg Glu Arg Ala 
305                 310                 315                 320 


Gln Ser Arg Ile Gln Glu Leu Glu Glu Lys Val Ala Ser Leu Leu His 
                325                 330                 335     


Gln Val Ser Trp Arg Gln Asp Ser Arg Glu Pro Asp Ala Gly Arg Ile 
            340                 345                 350         


His Ala Gly Ser Lys Thr Ala Lys Tyr Leu Ala Ala Asp Ala Leu Glu 
        355                 360                 365             


Leu Met Val Pro Gly Gly Trp Arg Pro Gly Thr Gly Ser Gln Gln Pro 
    370                 375                 380                 


Glu Pro Pro Ala Glu Gly Gly His Pro Gly Ala Val Gln Arg Gly Gln 
385                 390                 395                 400 


Gly Asp Leu Gln Cys Pro His Cys Leu Gln Cys Phe Ser Asp Glu Gln 
                405                 410                 415     


Gly Glu Glu Leu Leu Arg His Val Ala Glu Cys Cys Gln 
            420                 425                 


<210>  291
<211>  2568
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (324)..(2504)

<400>  291
gggaagatac acggttttta agaaagaact tctaacccca ctccaccgcc caacggtcac       60

gtgacgcgcc tgcgtcctcg cctcaaggtt ttttctggtc gcatattggc tgttaactcg      120

gctacggggt gtagcgaggt gcattccgga agtaggtcct ttgacttttg cttcctctac      180

ggaggcaagt aacaacccgg cggtcgacgc ttagcggaag ttcgtcaagt cgcagttgcc      240

cccgcacagc ggatgtgggt cgcctcttag gtgacgctgg gaagtgcctg caaccttcgc      300

cgctgccttc tggttgaagc act atg gag gga gag agg aag aac aac aac aaa      353
                          Met Glu Gly Glu Arg Lys Asn Asn Asn Lys         
                          1               5                   10          

cgg tgg tat ttc act cga gaa cag ctg gaa aat agc cca tcc cgt cgt        401
Arg Trp Tyr Phe Thr Arg Glu Gln Leu Glu Asn Ser Pro Ser Arg Arg           
                15                  20                  25                

ttt ggc gtg gac cca gat aaa gaa ctt tct tat cgc cag cag gcg gcc        449
Phe Gly Val Asp Pro Asp Lys Glu Leu Ser Tyr Arg Gln Gln Ala Ala           
            30                  35                  40                    

aat ctg ctt cag gac atg ggg cag cgt ctt aac gtc tca caa ttg act        497
Asn Leu Leu Gln Asp Met Gly Gln Arg Leu Asn Val Ser Gln Leu Thr           
        45                  50                  55                        

atc aac act gct ata gta tac atg cat cga ttc tac atg att cag tcc        545
Ile Asn Thr Ala Ile Val Tyr Met His Arg Phe Tyr Met Ile Gln Ser           
    60                  65                  70                            

ttc aca cag ttc cct gga aat tct gtg gct cca gca gcc ttg ttt cta        593
Phe Thr Gln Phe Pro Gly Asn Ser Val Ala Pro Ala Ala Leu Phe Leu           
75                  80                  85                  90            

gca gct aaa gtg gag gag cag ccc aaa aaa ttg gaa cat gtc atc aag        641
Ala Ala Lys Val Glu Glu Gln Pro Lys Lys Leu Glu His Val Ile Lys           
                95                  100                 105               

gta gca cat act tgt ctc cat cct cag gaa tcc ctt cct gat act aga        689
Val Ala His Thr Cys Leu His Pro Gln Glu Ser Leu Pro Asp Thr Arg           
            110                 115                 120                   

agt gag gct tat ttg caa caa gtt caa gat ctg gtc att tta gaa agc        737
Ser Glu Ala Tyr Leu Gln Gln Val Gln Asp Leu Val Ile Leu Glu Ser           
        125                 130                 135                       

ata att ttg cag act tta ggc ttt gaa cta aca att gat cac cca cat        785
Ile Ile Leu Gln Thr Leu Gly Phe Glu Leu Thr Ile Asp His Pro His           
    140                 145                 150                           

act cat gta gta aag tgc act caa ctt gtt cga gca agc aag gac tta        833
Thr His Val Val Lys Cys Thr Gln Leu Val Arg Ala Ser Lys Asp Leu           
155                 160                 165                 170           

gca cag act tct tac ttc atg gca acc aac agc ctg cat ttg acc aca        881
Ala Gln Thr Ser Tyr Phe Met Ala Thr Asn Ser Leu His Leu Thr Thr           
                175                 180                 185               

ttt agc ctg cag tac aca cct cct gtg gtg gcc tgt gtc tgc att cac        929
Phe Ser Leu Gln Tyr Thr Pro Pro Val Val Ala Cys Val Cys Ile His           
            190                 195                 200                   

ctg gct tgc aag tgg tcc aat tgg gag atc cca gtc tca act gac ggg        977
Leu Ala Cys Lys Trp Ser Asn Trp Glu Ile Pro Val Ser Thr Asp Gly           
        205                 210                 215                       

aag cac tgg tgg gag tat gtt gac gcc act gtg acc ttg gaa ctt tta       1025
Lys His Trp Trp Glu Tyr Val Asp Ala Thr Val Thr Leu Glu Leu Leu           
    220                 225                 230                           

gat gaa ctg aca cat gag ttt cta cag att ttg gag aaa act ccc aac       1073
Asp Glu Leu Thr His Glu Phe Leu Gln Ile Leu Glu Lys Thr Pro Asn           
235                 240                 245                 250           

agg ctc aaa cgc att tgg aat tgg agg gca tgc gag gct gcc aag aaa       1121
Arg Leu Lys Arg Ile Trp Asn Trp Arg Ala Cys Glu Ala Ala Lys Lys           
                255                 260                 265               

aca aaa gca gat gac cga gga aca gat gaa aag act tca gag cag aca       1169
Thr Lys Ala Asp Asp Arg Gly Thr Asp Glu Lys Thr Ser Glu Gln Thr           
            270                 275                 280                   

atc ctc aat atg att tcc cag agc tct tca gac aca acc att gca ggt       1217
Ile Leu Asn Met Ile Ser Gln Ser Ser Ser Asp Thr Thr Ile Ala Gly           
        285                 290                 295                       

tta atg agc atg tca act tct acc aca agt gca gtg cct tcc ctg cca       1265
Leu Met Ser Met Ser Thr Ser Thr Thr Ser Ala Val Pro Ser Leu Pro           
    300                 305                 310                           

gtc tcc gaa gag tca tcc agc aac tta acc agt gtg gag atg ttg ccg       1313
Val Ser Glu Glu Ser Ser Ser Asn Leu Thr Ser Val Glu Met Leu Pro           
315                 320                 325                 330           

ggc aag cgt tgg ctg tcc tcc caa cct tct ttc aaa cta gaa cct act       1361
Gly Lys Arg Trp Leu Ser Ser Gln Pro Ser Phe Lys Leu Glu Pro Thr           
                335                 340                 345               

cag ggt cat cgg act agt gag aat tta gca ctt aca gga gtt gat cat       1409
Gln Gly His Arg Thr Ser Glu Asn Leu Ala Leu Thr Gly Val Asp His           
            350                 355                 360                   

tcc tta cca cag gat ggt tca aat gca ttt att tcc cag aag cag aat       1457
Ser Leu Pro Gln Asp Gly Ser Asn Ala Phe Ile Ser Gln Lys Gln Asn           
        365                 370                 375                       

agt aag agt gtg cca tca gct aaa gtg tca ctg aaa gaa tac cgc gcg       1505
Ser Lys Ser Val Pro Ser Ala Lys Val Ser Leu Lys Glu Tyr Arg Ala           
    380                 385                 390                           

aag cat gca gaa gaa ttg gct gcc cag aag agg caa ctg gag aac atg       1553
Lys His Ala Glu Glu Leu Ala Ala Gln Lys Arg Gln Leu Glu Asn Met           
395                 400                 405                 410           

gaa gcc aat gtg aag tca caa tat gca tat gct gcc cag aat ctc ctt       1601
Glu Ala Asn Val Lys Ser Gln Tyr Ala Tyr Ala Ala Gln Asn Leu Leu           
                415                 420                 425               

tct cat cat gat agc cat tct tca gtc att cta aaa atg ccc ata gag       1649
Ser His His Asp Ser His Ser Ser Val Ile Leu Lys Met Pro Ile Glu           
            430                 435                 440                   

ggt tca gaa aac ccc gag cgg cct ttt ctg gaa aag gct gac aaa aca       1697
Gly Ser Glu Asn Pro Glu Arg Pro Phe Leu Glu Lys Ala Asp Lys Thr           
        445                 450                 455                       

gct ctc aaa atg aga atc cca gtg gca ggt gga gat aaa gct gcg tct       1745
Ala Leu Lys Met Arg Ile Pro Val Ala Gly Gly Asp Lys Ala Ala Ser           
    460                 465                 470                           

tca aaa cca gag gag ata aaa atg cgc ata aaa gtc cat gct gca gct       1793
Ser Lys Pro Glu Glu Ile Lys Met Arg Ile Lys Val His Ala Ala Ala           
475                 480                 485                 490           

gat aag cac aat tct gta gag gac agt gtt aca aag agc cga gag cac       1841
Asp Lys His Asn Ser Val Glu Asp Ser Val Thr Lys Ser Arg Glu His           
                495                 500                 505               

aaa gaa aag cac aag act cac cca tct aat cat cat cat cat cat aat       1889
Lys Glu Lys His Lys Thr His Pro Ser Asn His His His His His Asn           
            510                 515                 520                   

cac cac tca cac aag cac tct cat tcc caa ctt cca gtt ggt act ggg       1937
His His Ser His Lys His Ser His Ser Gln Leu Pro Val Gly Thr Gly           
        525                 530                 535                       

aac aaa cgt cct ggt gat cca aaa cat agt agc cag aca agc aac tta       1985
Asn Lys Arg Pro Gly Asp Pro Lys His Ser Ser Gln Thr Ser Asn Leu           
    540                 545                 550                           

gca cat aaa acc tat agc ttg tct agt tct ttt tcc tct tcc agt tct       2033
Ala His Lys Thr Tyr Ser Leu Ser Ser Ser Phe Ser Ser Ser Ser Ser           
555                 560                 565                 570           

act cgt aaa agg gga ccc tct gaa gag act gga ggg gct gtg ttt gat       2081
Thr Arg Lys Arg Gly Pro Ser Glu Glu Thr Gly Gly Ala Val Phe Asp           
                575                 580                 585               

cat cca gcc aag att gcc aag agt act aaa tcc tct tcc cta aat ttc       2129
His Pro Ala Lys Ile Ala Lys Ser Thr Lys Ser Ser Ser Leu Asn Phe           
            590                 595                 600                   

tcc ttc cct tca ctt cct aca atg ggt cag atg cct ggg cat agc tca       2177
Ser Phe Pro Ser Leu Pro Thr Met Gly Gln Met Pro Gly His Ser Ser           
        605                 610                 615                       

gac aca agt ggc ctt tcc ttt tca cag ccc agc tgt aaa act cgt gtc       2225
Asp Thr Ser Gly Leu Ser Phe Ser Gln Pro Ser Cys Lys Thr Arg Val           
    620                 625                 630                           

cct cat tcg aaa ctg gat aaa ggg ccc act ggg gcc aat ggt cac aac       2273
Pro His Ser Lys Leu Asp Lys Gly Pro Thr Gly Ala Asn Gly His Asn           
635                 640                 645                 650           

acg acc cag aca ata gac tat caa gac act gtg aat atg ctt cac tcc       2321
Thr Thr Gln Thr Ile Asp Tyr Gln Asp Thr Val Asn Met Leu His Ser           
                655                 660                 665               

ctg ctc agt gcc cag ggt gtt cag ccc act cag ccc act gca ttt gaa       2369
Leu Leu Ser Ala Gln Gly Val Gln Pro Thr Gln Pro Thr Ala Phe Glu           
            670                 675                 680                   

ttt gtt cgt cct tat agt gac tat ctg aat cct cgg tct ggt gga atc       2417
Phe Val Arg Pro Tyr Ser Asp Tyr Leu Asn Pro Arg Ser Gly Gly Ile           
        685                 690                 695                       

tcc tcg aga tct ggc aat aca gac aaa ccc cgg cca cca cct ctg cca       2465
Ser Ser Arg Ser Gly Asn Thr Asp Lys Pro Arg Pro Pro Pro Leu Pro           
    700                 705                 710                           

tca gaa cct cct cca cca ctt cca ccc ctt cct aag taa aaaaagaaaa        2514
Ser Glu Pro Pro Pro Pro Leu Pro Pro Leu Pro Lys                           
715                 720                 725                               

agaagaggag aaaaaaactt ctttaaaaaa acacataatt tttctttttt tttt           2568


<210>  292
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Glu Gly Glu Arg Lys Asn Asn Asn Lys Arg Trp Tyr Phe Thr Arg 
1               5                   10                  15      


Glu Gln Leu Glu Asn Ser Pro Ser Arg Arg Phe Gly Val Asp Pro Asp 
            20                  25                  30          


Lys Glu Leu Ser Tyr Arg Gln Gln Ala Ala Asn Leu Leu Gln Asp Met 
        35                  40                  45              


Gly Gln Arg Leu Asn Val Ser Gln Leu Thr Ile Asn Thr Ala Ile Val 
    50                  55                  60                  


Tyr Met His Arg Phe Tyr Met Ile Gln Ser Phe Thr Gln Phe Pro Gly 
65                  70                  75                  80  


Asn Ser Val Ala Pro Ala Ala Leu Phe Leu Ala Ala Lys Val Glu Glu 
                85                  90                  95      


Gln Pro Lys Lys Leu Glu His Val Ile Lys Val Ala His Thr Cys Leu 
            100                 105                 110         


His Pro Gln Glu Ser Leu Pro Asp Thr Arg Ser Glu Ala Tyr Leu Gln 
        115                 120                 125             


Gln Val Gln Asp Leu Val Ile Leu Glu Ser Ile Ile Leu Gln Thr Leu 
    130                 135                 140                 


Gly Phe Glu Leu Thr Ile Asp His Pro His Thr His Val Val Lys Cys 
145                 150                 155                 160 


Thr Gln Leu Val Arg Ala Ser Lys Asp Leu Ala Gln Thr Ser Tyr Phe 
                165                 170                 175     


Met Ala Thr Asn Ser Leu His Leu Thr Thr Phe Ser Leu Gln Tyr Thr 
            180                 185                 190         


Pro Pro Val Val Ala Cys Val Cys Ile His Leu Ala Cys Lys Trp Ser 
        195                 200                 205             


Asn Trp Glu Ile Pro Val Ser Thr Asp Gly Lys His Trp Trp Glu Tyr 
    210                 215                 220                 


Val Asp Ala Thr Val Thr Leu Glu Leu Leu Asp Glu Leu Thr His Glu 
225                 230                 235                 240 


Phe Leu Gln Ile Leu Glu Lys Thr Pro Asn Arg Leu Lys Arg Ile Trp 
                245                 250                 255     


Asn Trp Arg Ala Cys Glu Ala Ala Lys Lys Thr Lys Ala Asp Asp Arg 
            260                 265                 270         


Gly Thr Asp Glu Lys Thr Ser Glu Gln Thr Ile Leu Asn Met Ile Ser 
        275                 280                 285             


Gln Ser Ser Ser Asp Thr Thr Ile Ala Gly Leu Met Ser Met Ser Thr 
    290                 295                 300                 


Ser Thr Thr Ser Ala Val Pro Ser Leu Pro Val Ser Glu Glu Ser Ser 
305                 310                 315                 320 


Ser Asn Leu Thr Ser Val Glu Met Leu Pro Gly Lys Arg Trp Leu Ser 
                325                 330                 335     


Ser Gln Pro Ser Phe Lys Leu Glu Pro Thr Gln Gly His Arg Thr Ser 
            340                 345                 350         


Glu Asn Leu Ala Leu Thr Gly Val Asp His Ser Leu Pro Gln Asp Gly 
        355                 360                 365             


Ser Asn Ala Phe Ile Ser Gln Lys Gln Asn Ser Lys Ser Val Pro Ser 
    370                 375                 380                 


Ala Lys Val Ser Leu Lys Glu Tyr Arg Ala Lys His Ala Glu Glu Leu 
385                 390                 395                 400 


Ala Ala Gln Lys Arg Gln Leu Glu Asn Met Glu Ala Asn Val Lys Ser 
                405                 410                 415     


Gln Tyr Ala Tyr Ala Ala Gln Asn Leu Leu Ser His His Asp Ser His 
            420                 425                 430         


Ser Ser Val Ile Leu Lys Met Pro Ile Glu Gly Ser Glu Asn Pro Glu 
        435                 440                 445             


Arg Pro Phe Leu Glu Lys Ala Asp Lys Thr Ala Leu Lys Met Arg Ile 
    450                 455                 460                 


Pro Val Ala Gly Gly Asp Lys Ala Ala Ser Ser Lys Pro Glu Glu Ile 
465                 470                 475                 480 


Lys Met Arg Ile Lys Val His Ala Ala Ala Asp Lys His Asn Ser Val 
                485                 490                 495     


Glu Asp Ser Val Thr Lys Ser Arg Glu His Lys Glu Lys His Lys Thr 
            500                 505                 510         


His Pro Ser Asn His His His His His Asn His His Ser His Lys His 
        515                 520                 525             


Ser His Ser Gln Leu Pro Val Gly Thr Gly Asn Lys Arg Pro Gly Asp 
    530                 535                 540                 


Pro Lys His Ser Ser Gln Thr Ser Asn Leu Ala His Lys Thr Tyr Ser 
545                 550                 555                 560 


Leu Ser Ser Ser Phe Ser Ser Ser Ser Ser Thr Arg Lys Arg Gly Pro 
                565                 570                 575     


Ser Glu Glu Thr Gly Gly Ala Val Phe Asp His Pro Ala Lys Ile Ala 
            580                 585                 590         


Lys Ser Thr Lys Ser Ser Ser Leu Asn Phe Ser Phe Pro Ser Leu Pro 
        595                 600                 605             


Thr Met Gly Gln Met Pro Gly His Ser Ser Asp Thr Ser Gly Leu Ser 
    610                 615                 620                 


Phe Ser Gln Pro Ser Cys Lys Thr Arg Val Pro His Ser Lys Leu Asp 
625                 630                 635                 640 


Lys Gly Pro Thr Gly Ala Asn Gly His Asn Thr Thr Gln Thr Ile Asp 
                645                 650                 655     


Tyr Gln Asp Thr Val Asn Met Leu His Ser Leu Leu Ser Ala Gln Gly 
            660                 665                 670         


Val Gln Pro Thr Gln Pro Thr Ala Phe Glu Phe Val Arg Pro Tyr Ser 
        675                 680                 685             


Asp Tyr Leu Asn Pro Arg Ser Gly Gly Ile Ser Ser Arg Ser Gly Asn 
    690                 695                 700                 


Thr Asp Lys Pro Arg Pro Pro Pro Leu Pro Ser Glu Pro Pro Pro Pro 
705                 710                 715                 720 


Leu Pro Pro Leu Pro Lys 
                725     


<210>  293
<211>  4045
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (132)..(1787)

<400>  293
gcagccagag ctcagcaggg ccctggagag atggccacgg tcccagcacc ggggaggact       60

ggagagcgcg cgctgccacc gccccatgtc tcagccaggg cttccttcct cggctccacc      120

ctgtggatgt a atg gcg gcc cct gct ctg tcc tgg cgt ctg ccc ctc ctc       170
             Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu          
             1               5                   10                       

atc ctc ctc ctg ccc ctg gct acc tct tgg gca tct gca gcg gtg aat        218
Ile Leu Leu Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn           
    15                  20                  25                            

ggc act tcc cag ttc aca tgc ttc tac aac tcg aga gcc aac atc tcc        266
Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser           
30                  35                  40                  45            

tgt gtc tgg agc caa gat ggg gct ctg cag gac act tcc tgc caa gtc        314
Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val           
                50                  55                  60                

cat gcc tgg ccg gac aga cgg cgg tgg aac caa acc tgt gag ctg ctc        362
His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu           
            65                  70                  75                    

ccc gtg agt caa gca tcc tgg gcc tgc aac ctg atc ctc gga gcc cca        410
Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro           
        80                  85                  90                        

gat tct cag aaa ctg acc aca gtt gac atc gtc acc ctg agg gtg ctg        458
Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu           
    95                  100                 105                           

tgc cgt gag ggg gtg cga tgg agg gtg atg gcc atc cag gac ttc aag        506
Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys           
110                 115                 120                 125           

ccc ttt gag aac ctt cgc ctg atg gcc ccc atc tcc ctc caa gtt gtc        554
Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val           
                130                 135                 140               

cac gtg gag acc cac aga tgc aac ata agc tgg gaa atc tcc caa gcc        602
His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala           
            145                 150                 155                   

tcc cac tac ttt gaa aga cac ctg gag ttc gag gcc cgg acg ctg tcc        650
Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser           
        160                 165                 170                       

cca ggc cac acc tgg gag gag gcc ccc ctg ctg act ctc aag cag aag        698
Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys           
    175                 180                 185                           

cag gaa tgg atc tgc ctg gag acg ctc acc cca gac acc cag tat gag        746
Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu           
190                 195                 200                 205           

ttt cag gtg cgg gtc aag cct ctg caa ggc gag ttc acg acc tgg agc        794
Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser           
                210                 215                 220               

ccc tgg agc cag ccc ctg gcc ttc agg aca aag cct gca gcc ctt ggg        842
Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly           
            225                 230                 235                   

aag gac acc att ccg tgg ctc ggc cac ctc ctc gtg ggc ctc agc ggg        890
Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly           
        240                 245                 250                       

gct ttt ggc ttc atc atc tta gtg tac ttg ctg atc aac tgc agg aac        938
Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn           
    255                 260                 265                           

acc ggg cca tgg ctg aag aag gtc ctg aag tgt aac acc cca gac ccc        986
Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro           
270                 275                 280                 285           

tcg aag ttc ttt tcc cag ctg agc tca gag cat gga gga gac gtc cag       1034
Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln           
                290                 295                 300               

aag tgg ctc tct tcg ccc ttc ccc tca tcg tcc ttc agc cct ggc ggc       1082
Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly           
            305                 310                 315                   

ctg gca cct gag atc tcg cca cta gaa gtg ctg gag agg gac aag gtg       1130
Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val           
        320                 325                 330                       

acg cag ctg ctc ctg cag cag gac aag gtg cct gag ccc gca tcc tta       1178
Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu           
    335                 340                 345                           

agc agc aac cac tcg ctg acc agc tgc ttc acc aac cag ggt tac ttc       1226
Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe           
350                 355                 360                 365           

ttc ttc cac ctc ccg gat gcc ttg gag ata gag gcc tgc cag gtg tac       1274
Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr           
                370                 375                 380               

ttt act tac gac ccc tac tca gag gaa gac cct gat gag ggt gtg gcc       1322
Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala           
            385                 390                 395                   

ggg gca ccc aca ggg tct tcc ccc caa ccc ctg cag cct ctg tca ggg       1370
Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly           
        400                 405                 410                       

gag gac gac gcc tac tgc acc ttc ccc tcc agg gat gac ctg ctg ctc       1418
Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu           
    415                 420                 425                           

ttc tcc ccc agt ctc ctc ggt ggc ccc agc ccc cca agc act gcc cct       1466
Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro           
430                 435                 440                 445           

ggg ggc agt ggg gcc ggt gaa gag agg atg ccc cct tct ttg caa gaa       1514
Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu           
                450                 455                 460               

aga gtc ccc aga gac tgg gac ccc cag ccc ctg ggg cct ccc acc cca       1562
Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro           
            465                 470                 475                   

gga gtc cca gac ctg gtg gat ttt cag cca ccc cct gag ctg gtg ctg       1610
Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu           
        480                 485                 490                       

cga gag gct ggg gag gag gtc cct gac gct ggc ccc agg gag gga gtc       1658
Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val           
    495                 500                 505                           

agt ttc ccc tgg tcc agg cct cct ggg cag ggg gag ttc agg gcc ctt       1706
Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu           
510                 515                 520                 525           

aat gct cgc ctg ccc ctg aac act gat gcc tac ttg tcc ctc caa gaa       1754
Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu           
                530                 535                 540               

ctc cag ggt cag gac cca act cac ttg gtg tag acagatggcc agggtgggag     1807
Leu Gln Gly Gln Asp Pro Thr His Leu Val                                   
            545                 550                                       

gcaggcagct gcctgctctg cgccgagcct cagaaggacc ctgttgaggg tcctcagtcc     1867

actgctgagg acactcagtg tccagttgca gctggacttc tccacccgga tggcccccac     1927

ccagtcctgc acacttggtc catccatttc caaacctcca ctgctgctcc cgggtcctgc     1987

tgcccgagcc aggaactgtg tgtgttgcag gggggcagta actccccaac tccctcgtta     2047

atcacaggat cccacgaatt taggctcaga agcatcgctc ctctccagcc ctgcagctat     2107

tcaccaatat cagtcctcgc ggctctccag ggctccctgc cctgacctct tccctgggtt     2167

ttctgcccca gcctcctcct tccctcccct ccccgtccac agggcagcct gagcgtgctt     2227

tccaaaaccc aaatatggcc acgctccccc tcggttcaaa accttgcaca ggtcccactg     2287

ccctcagccc cacttctcag cctggtactt gtacctccgg tgtcgtgtgg ggacatcccc     2347

ttctgcaatc ctccctaccg tcctcctgag ccactcagag ctccctcaca ccccctctgt     2407

tgcacatgct attccctggg gctgctgtgc gctccccctc atctaggtga caaacttccc     2467

tgactcttca agtgccggtt ttgcttctcc tggagggaag cactgcctcc cttaatctgc     2527

cagaaacttc tagcgtcagt gctggaggga gaagctgtca gggacccagg gcgcctggag     2587

aaagaggccc tgttactatt cctttgggat ctctgaggcc tcagagtgct tggctgctgt     2647

atctttaatg ctggggccca agtaagggca cagatccccc cacaaagtgg atgcctgctg     2707

catcttccca cagtggcttc acagacccac aagagaagct gatggggagt aaaccctgga     2767

gtccgaggcc caggcagcag ccccgcctag tggtgggccc tgatgctgcc aggcctggga     2827

cctcccactg ccccctccac tggaggggtc tcctctgcag ctcagggact ggcacactgg     2887

cctccagaag ggcagctcca cagggcaggg cctcattatt tttcactgcc ccagacacag     2947

tgcccaacac cccgtcgtat accctggatg aacgaattaa ttacctggca ccacctcgtc     3007

tgggctccct gcgcctgaca ttcacacaga gaggcagagt cccgtgccca ttaggtctgg     3067

catgccccct cctgcaaggg gctcaacccc ctaccccgac ccctccacgt atctttccta     3127

ggcagatcac gttgcaatgg ctcaaacaac attccacccc agcaggacag tgaccccagt     3187

cccagctaac tctgacctgg gagccctcag gcacctgcac ttacaggcct tgctcacagc     3247

tgattgggca cctgaccaca cgcccccaca ggctctgacc agcagcctat gagggggttt     3307

ggcaccaagc tctgtccaat caggtaggct gggcctgaac tagccaatca gatcaactct     3367

gtcttgggcg tttgaactca gggagggagg cccttgggag caggtgcttg tggacaaggc     3427

tccacaagcg ttgagccttg gaaaggtaga caagcgttga gccactaagc agaggacctt     3487

gggttcccaa tacaaaaata cctactgctg agagggctgc tgaccatttg gtcaggattc     3547

ctgttgcctt tatatccaaa ataaactccc ctttcttgag gttgtctgag tcttgggtct     3607

atgccttgaa aaaagctgaa ttattggaca gtctcacctc ctgccatagg gtcctgaatg     3667

tttcagacca caaggggctc cacacctttg ctgtgtgttc tggggcaacc tactaatcct     3727

ctctgcaagt cggtctcctt atccccccaa atggaaattg tatttgcctt ctccactttg     3787

ggaggctccc acttcttggg agggttacat tttttaagtc ttaatcattt gtgacatatg     3847

tatctataca tccgtatctt ttaatgatcc gtgtgtacca tctttgtgat tatttcctta     3907

atattttttc tttaagtcag ttcattttcg ttgaaataca tttatttaaa gaaaaatctt     3967

tgttactctg taaatgaaaa aacccatttt cgctataaat aaaaggtaac tgtacaaaat     4027

aagtacaatg caacaaaa                                                   4045


<210>  294
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp 
            180                 185                 190         


Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
        195                 200                 205             


Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
    210                 215                 220                 


Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
225                 230                 235                 240 


Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
                245                 250                 255     


Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro 
            260                 265                 270         


Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe 
        275                 280                 285             


Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu 
    290                 295                 300                 


Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro 
305                 310                 315                 320 


Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu 
                325                 330                 335     


Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
            340                 345                 350         


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
        355                 360                 365             


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr 
    370                 375                 380                 


Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro 
385                 390                 395                 400 


Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp 
                405                 410                 415     


Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro 
            420                 425                 430         


Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser 
        435                 440                 445             


Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro 
    450                 455                 460                 


Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro 
465                 470                 475                 480 


Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala 
                485                 490                 495     


Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro 
            500                 505                 510         


Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg 
        515                 520                 525             


Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
    530                 535                 540                 


Gln Asp Pro Thr His Leu Val 
545                 550     


<210>  295
<211>  820
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (255)..(524)

<400>  295
gggagagcct ggggccgggc cgtgtggatg ccatccccga gcgcggttcg cgctcggctg       60

aggcgctgga caagtggctt gggctcccgc gcctcagttt ctctctgtgg cgccgcctac      120

ctcacagact tgtgagcact cactgacgtg ggtagcgccc agggcctgcg gggcgcagga      180

gagctggagt caggcggaga ccgcaggctg accccgcagc ggccgggctg tcgcggcccc      240

cacctcaggt aacc atg tgc gac cga aag gcc gtg atc aaa aat gcg gac        290
                Met Cys Asp Arg Lys Ala Val Ile Lys Asn Ala Asp           
                1               5                   10                    

atg tcg gaa gag atg caa cag gac tcg gtg gag tgc gct act cag gcg        338
Met Ser Glu Glu Met Gln Gln Asp Ser Val Glu Cys Ala Thr Gln Ala           
        15                  20                  25                        

ctg gag aaa tac aac ata gag aag gac att gcg gct cat atc aag aag        386
Leu Glu Lys Tyr Asn Ile Glu Lys Asp Ile Ala Ala His Ile Lys Lys           
    30                  35                  40                            

gaa ttt gac aag aag tac aat ccc acc tgg cat tgc atc gtg ggg agg        434
Glu Phe Asp Lys Lys Tyr Asn Pro Thr Trp His Cys Ile Val Gly Arg           
45                  50                  55                  60            

aac ttc ggt agt tat gtg aca cat gaa acc aaa cac ttc atc tac ttc        482
Asn Phe Gly Ser Tyr Val Thr His Glu Thr Lys His Phe Ile Tyr Phe           
                65                  70                  75                

tac ctg ggc caa gtg gcc att ctt ctg ttc aaa tct ggt taa                524
Tyr Leu Gly Gln Val Ala Ile Leu Leu Phe Lys Ser Gly                       
            80                  85                                        

aagcatggac tgtgccacac acccagtgat ccatccaaaa acaaggactg cagcctaaat      584

tccaaatacc agagactgaa attttcagcc ttgctaaggg aacatctcga tgtttgaacc      644

tttgttgtgt tttgtacagg gcattctctg tactagtttg tcgtggttat aaaacaatta      704

gcagaatagc ctacatttgt atttattttc tattccatac ttctgcccac gttgttttct      764

ctcaaaatcc attcctttaa aaaataaatc tgatgcagat gtgtaaaaaa aaaaaa          820


<210>  296
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Cys Asp Arg Lys Ala Val Ile Lys Asn Ala Asp Met Ser Glu Glu 
1               5                   10                  15      


Met Gln Gln Asp Ser Val Glu Cys Ala Thr Gln Ala Leu Glu Lys Tyr 
            20                  25                  30          


Asn Ile Glu Lys Asp Ile Ala Ala His Ile Lys Lys Glu Phe Asp Lys 
        35                  40                  45              


Lys Tyr Asn Pro Thr Trp His Cys Ile Val Gly Arg Asn Phe Gly Ser 
    50                  55                  60                  


Tyr Val Thr His Glu Thr Lys His Phe Ile Tyr Phe Tyr Leu Gly Gln 
65                  70                  75                  80  


Val Ala Ile Leu Leu Phe Lys Ser Gly 
                85                  


<210>  297
<211>  3912
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (50)..(3535)

<400>  297
ctgtgctctg tccccaacct tccacttccc ctcaacgcgc tgctcaggg atg acc ttc       58
                                                      Met Thr Phe         
                                                      1                   

ggc act gtg ctt ctt ctg agt gtc ctg gct tct tat cat gga ttc aac        106
Gly Thr Val Leu Leu Leu Ser Val Leu Ala Ser Tyr His Gly Phe Asn           
    5                   10                  15                            

ctg gat gtg gag gag cct acg atc ttc cag gag gat gca ggc ggc ttt        154
Leu Asp Val Glu Glu Pro Thr Ile Phe Gln Glu Asp Ala Gly Gly Phe           
20                  25                  30                  35            

ggg cag agc gtg gtg cag ttc ggt gga tct cga ctc gtg gtg gga gca        202
Gly Gln Ser Val Val Gln Phe Gly Gly Ser Arg Leu Val Val Gly Ala           
                40                  45                  50                

ccc ctg gag gtg gtg gcg gcc aac cag acg gga cgg ctg tat gac tgc        250
Pro Leu Glu Val Val Ala Ala Asn Gln Thr Gly Arg Leu Tyr Asp Cys           
            55                  60                  65                    

gca gct gcc acc ggc atg tgc cag ccc atc ccg ctg cac atc cgc cct        298
Ala Ala Ala Thr Gly Met Cys Gln Pro Ile Pro Leu His Ile Arg Pro           
        70                  75                  80                        

gag gcc gtg aac atg tcc ttg ggc ctg acc ctg gca gcc tcc acc aac        346
Glu Ala Val Asn Met Ser Leu Gly Leu Thr Leu Ala Ala Ser Thr Asn           
    85                  90                  95                            

ggc tcc cgg ctc ctg gcc tgt ggc ccg acc ctg cac aga gtc tgt ggg        394
Gly Ser Arg Leu Leu Ala Cys Gly Pro Thr Leu His Arg Val Cys Gly           
100                 105                 110                 115           

gag aac tca tac tca aag ggt tcc tgc ctc ctg ctg ggc tcg cgc tgg        442
Glu Asn Ser Tyr Ser Lys Gly Ser Cys Leu Leu Leu Gly Ser Arg Trp           
                120                 125                 130               

gag atc atc cag aca gtc ccc gac gcc acg cca gag tgt cca cat caa        490
Glu Ile Ile Gln Thr Val Pro Asp Ala Thr Pro Glu Cys Pro His Gln           
            135                 140                 145                   

gag atg gac atc gtc ttc ctg att gac ggc tct gga agc att gac caa        538
Glu Met Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser Ile Asp Gln           
        150                 155                 160                       

aat gac ttt aac cag atg aag ggc ttt gtc caa gct gtc atg ggc cag        586
Asn Asp Phe Asn Gln Met Lys Gly Phe Val Gln Ala Val Met Gly Gln           
    165                 170                 175                           

ttt gag ggc act gac acc ctg ttt gca ctg atg cag tac tca aac ctc        634
Phe Glu Gly Thr Asp Thr Leu Phe Ala Leu Met Gln Tyr Ser Asn Leu           
180                 185                 190                 195           

ctg aag atc cac ttc acc ttc acc caa ttc cgg acc agc ccg agc cag        682
Leu Lys Ile His Phe Thr Phe Thr Gln Phe Arg Thr Ser Pro Ser Gln           
                200                 205                 210               

cag agc ctg gtg gat ccc atc gtc caa ctg aaa ggc ctg acg ttc acg        730
Gln Ser Leu Val Asp Pro Ile Val Gln Leu Lys Gly Leu Thr Phe Thr           
            215                 220                 225                   

gcc acg ggc atc ctg aca gtg gtg aca cag cta ttt cat cat aag aat        778
Ala Thr Gly Ile Leu Thr Val Val Thr Gln Leu Phe His His Lys Asn           
        230                 235                 240                       

ggg gcc cga aaa agt gcc aag aag atc ctc att gtc atc aca gat ggg        826
Gly Ala Arg Lys Ser Ala Lys Lys Ile Leu Ile Val Ile Thr Asp Gly           
    245                 250                 255                           

cag aag tac aaa gac ccc ctg gaa tac agt gat gtc atc ccc cag gca        874
Gln Lys Tyr Lys Asp Pro Leu Glu Tyr Ser Asp Val Ile Pro Gln Ala           
260                 265                 270                 275           

gag aag gct ggc atc atc cgc tac gct atc ggg gtg gga cac gct ttc        922
Glu Lys Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly His Ala Phe           
                280                 285                 290               

cag gga ccc act gcc agg cag gag ctg aat acc atc agc tca gcg cct        970
Gln Gly Pro Thr Ala Arg Gln Glu Leu Asn Thr Ile Ser Ser Ala Pro           
            295                 300                 305                   

ccg cag gac cac gtg ttc aag gtg gac aac ttt gca gcc ctt ggc agc       1018
Pro Gln Asp His Val Phe Lys Val Asp Asn Phe Ala Ala Leu Gly Ser           
        310                 315                 320                       

atc cag aag cag ctg cag gag aag atc tat gca gtt gag gga acc cag       1066
Ile Gln Lys Gln Leu Gln Glu Lys Ile Tyr Ala Val Glu Gly Thr Gln           
    325                 330                 335                           

tcc agg gca agc agc tcc ttc cag cac gag atg tcc caa gaa ggc ttc       1114
Ser Arg Ala Ser Ser Ser Phe Gln His Glu Met Ser Gln Glu Gly Phe           
340                 345                 350                 355           

agc aca gcc ctc aca atg gat ggc ctc ttc ctg ggg gct gtg ggg agc       1162
Ser Thr Ala Leu Thr Met Asp Gly Leu Phe Leu Gly Ala Val Gly Ser           
                360                 365                 370               

ttt agc tgg tct gga ggt gcc ttc ctg tat ccc cca aat atg agc ccc       1210
Phe Ser Trp Ser Gly Gly Ala Phe Leu Tyr Pro Pro Asn Met Ser Pro           
            375                 380                 385                   

acc ttc atc aac atg tct cag gag aat gtg gac atg agg gac tct tac       1258
Thr Phe Ile Asn Met Ser Gln Glu Asn Val Asp Met Arg Asp Ser Tyr           
        390                 395                 400                       

ctg ggt tac tcc acc gag cta gcc ctg tgg aag ggg gta cag aac ctg       1306
Leu Gly Tyr Ser Thr Glu Leu Ala Leu Trp Lys Gly Val Gln Asn Leu           
    405                 410                 415                           

gtc ctg ggg gcc ccc cgc tac cag cat acc ggg aag gct gtc atc ttc       1354
Val Leu Gly Ala Pro Arg Tyr Gln His Thr Gly Lys Ala Val Ile Phe           
420                 425                 430                 435           

acc cag gtg tcc agg caa tgg agg aag aag gcc gaa gtc aca ggg acg       1402
Thr Gln Val Ser Arg Gln Trp Arg Lys Lys Ala Glu Val Thr Gly Thr           
                440                 445                 450               

cag atc ggc tcc tac ttc ggg gcc tcc ctc tgc tcc gtg gat gtg gac       1450
Gln Ile Gly Ser Tyr Phe Gly Ala Ser Leu Cys Ser Val Asp Val Asp           
            455                 460                 465                   

agc gat ggc agc acc gac ctg atc ctc att ggg gcc ccc cat tac tat       1498
Ser Asp Gly Ser Thr Asp Leu Ile Leu Ile Gly Ala Pro His Tyr Tyr           
        470                 475                 480                       

gag cag acc cga ggg ggc cag gtg tcc gtg tgt ccc ttg cct agg ggg       1546
Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu Pro Arg Gly           
    485                 490                 495                           

agg gtg cag tgg cag tgt gac gct gtt ctc cgt ggt gag cag ggc cac       1594
Arg Val Gln Trp Gln Cys Asp Ala Val Leu Arg Gly Glu Gln Gly His           
500                 505                 510                 515           

ccc tgg ggc cgc ttt ggg gca gcc ctg aca gtg ttg ggg gat gtg aat       1642
Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu Gly Asp Val Asn           
                520                 525                 530               

gag gac aag ctg ata gac gtg gcc att ggg gcc ccg gga gag cag gag       1690
Glu Asp Lys Leu Ile Asp Val Ala Ile Gly Ala Pro Gly Glu Gln Glu           
            535                 540                 545                   

aac cgg ggt gct gtc tac ctg ttt cac gga gcc tca gaa tcc ggc atc       1738
Asn Arg Gly Ala Val Tyr Leu Phe His Gly Ala Ser Glu Ser Gly Ile           
        550                 555                 560                       

agc ccc tcc cac agc cag cgg att gcc agc tcc cag ctc tcc ccc agg       1786
Ser Pro Ser His Ser Gln Arg Ile Ala Ser Ser Gln Leu Ser Pro Arg           
    565                 570                 575                           

ctg cag tat ttt ggg cag gcg ctg agt ggg ggt cag gac ctc acc cag       1834
Leu Gln Tyr Phe Gly Gln Ala Leu Ser Gly Gly Gln Asp Leu Thr Gln           
580                 585                 590                 595           

gat gga ctg atg gac ctg gcc gtg ggg gcc cgg ggc cag gtg ctc ctg       1882
Asp Gly Leu Met Asp Leu Ala Val Gly Ala Arg Gly Gln Val Leu Leu           
                600                 605                 610               

ctc agg agt ctg ccg gtg ctg aaa gtg ggg gtg gcc atg aga ttc agc       1930
Leu Arg Ser Leu Pro Val Leu Lys Val Gly Val Ala Met Arg Phe Ser           
            615                 620                 625                   

cct gtg gag gtg gcc aag gct gtg tac cgg tgc tgg gaa gag aag ccc       1978
Pro Val Glu Val Ala Lys Ala Val Tyr Arg Cys Trp Glu Glu Lys Pro           
        630                 635                 640                       

agt gcc ctg gaa gct ggg gac gcc acc gtc tgt ctc acc atc cag aaa       2026
Ser Ala Leu Glu Ala Gly Asp Ala Thr Val Cys Leu Thr Ile Gln Lys           
    645                 650                 655                           

agc tca ctg gac cag cta ggt gac atc caa agc tct gtc agg ttt gat       2074
Ser Ser Leu Asp Gln Leu Gly Asp Ile Gln Ser Ser Val Arg Phe Asp           
660                 665                 670                 675           

ctg gca ctg gac cca ggt cgt ctg act tct cgt gcc att ttc aat gaa       2122
Leu Ala Leu Asp Pro Gly Arg Leu Thr Ser Arg Ala Ile Phe Asn Glu           
                680                 685                 690               

acc aag aac ccc act ttg act cga aga aaa acc ctg gga ctg ggg att       2170
Thr Lys Asn Pro Thr Leu Thr Arg Arg Lys Thr Leu Gly Leu Gly Ile           
            695                 700                 705                   

cac tgt gaa acc ctg aag ctg ctt ttg cca gat tgt gtg gag gat gtg       2218
His Cys Glu Thr Leu Lys Leu Leu Leu Pro Asp Cys Val Glu Asp Val           
        710                 715                 720                       

gtg agc ccc atc att ctg cac ctc aac ttc tca ctg gtg aga gag ccc       2266
Val Ser Pro Ile Ile Leu His Leu Asn Phe Ser Leu Val Arg Glu Pro           
    725                 730                 735                           

atc ccc tcc ccc cag aac ctg cgt cct gtg ctg gcc gtg ggc tca caa       2314
Ile Pro Ser Pro Gln Asn Leu Arg Pro Val Leu Ala Val Gly Ser Gln           
740                 745                 750                 755           

gac ctc ttc act gct tct ctc ccc ttc gag aag aac tgt ggg caa gat       2362
Asp Leu Phe Thr Ala Ser Leu Pro Phe Glu Lys Asn Cys Gly Gln Asp           
                760                 765                 770               

ggc ctc tgt gaa ggg gac ctg ggt gtc acc ctc agc ttc tca ggc ctg       2410
Gly Leu Cys Glu Gly Asp Leu Gly Val Thr Leu Ser Phe Ser Gly Leu           
            775                 780                 785                   

cag acc ctg acc gtg ggg agc tcc ctg gag ctc aac gtg att gtg act       2458
Gln Thr Leu Thr Val Gly Ser Ser Leu Glu Leu Asn Val Ile Val Thr           
        790                 795                 800                       

gtg tgg aac gca ggt gag gat tcc tac gga acc gtg gtc agc ctc tac       2506
Val Trp Asn Ala Gly Glu Asp Ser Tyr Gly Thr Val Val Ser Leu Tyr           
    805                 810                 815                           

tat cca gca ggg ctg tcg cac cga cgg gtg tca gga gcc cag aag cag       2554
Tyr Pro Ala Gly Leu Ser His Arg Arg Val Ser Gly Ala Gln Lys Gln           
820                 825                 830                 835           

ccc cat cag agt gcc ctg cgc ctg gca tgt gag aca gtg ccc act gag       2602
Pro His Gln Ser Ala Leu Arg Leu Ala Cys Glu Thr Val Pro Thr Glu           
                840                 845                 850               

gat gag ggc cta aga agc agc cgc tgc agt gtc aac cac ccc atc ttc       2650
Asp Glu Gly Leu Arg Ser Ser Arg Cys Ser Val Asn His Pro Ile Phe           
            855                 860                 865                   

cat gag ggc tct aac ggc acc ttc ata gtc aca ttc gat gtc tcc tac       2698
His Glu Gly Ser Asn Gly Thr Phe Ile Val Thr Phe Asp Val Ser Tyr           
        870                 875                 880                       

aag gcc acc ctg gga gac agg atg ctt atg agg gcc agt gca agc agt       2746
Lys Ala Thr Leu Gly Asp Arg Met Leu Met Arg Ala Ser Ala Ser Ser           
    885                 890                 895                           

gag aac aat aag gct tca agc agc aag gcc acc ttc cag ctg gag ctc       2794
Glu Asn Asn Lys Ala Ser Ser Ser Lys Ala Thr Phe Gln Leu Glu Leu           
900                 905                 910                 915           

ccg gtg aag tat gca gtc tac acc atg atc agc agg cag gaa gaa tcc       2842
Pro Val Lys Tyr Ala Val Tyr Thr Met Ile Ser Arg Gln Glu Glu Ser           
                920                 925                 930               

acc aag tac ttc aac ttt gca acc tcc gat gag aag aaa atg aaa gag       2890
Thr Lys Tyr Phe Asn Phe Ala Thr Ser Asp Glu Lys Lys Met Lys Glu           
            935                 940                 945                   

gct gag cat cga tac cgt gtg aat aac ctc agc cag cga gat ctg gcc       2938
Ala Glu His Arg Tyr Arg Val Asn Asn Leu Ser Gln Arg Asp Leu Ala           
        950                 955                 960                       

atc agc att aac ttc tgg gtt cct gtc ctg ctg aac ggg gtg gct gtg       2986
Ile Ser Ile Asn Phe Trp Val Pro Val Leu Leu Asn Gly Val Ala Val           
    965                 970                 975                           

tgg gat gtg gtc atg gag gcc cca tct cag agt ctc ccc tgt gtt tca       3034
Trp Asp Val Val Met Glu Ala Pro Ser Gln Ser Leu Pro Cys Val Ser           
980                 985                 990                 995           

gag aga aaa cct ccc  cag cat tct gac ttc  ctg acc cag att tca         3079
Glu Arg Lys Pro Pro  Gln His Ser Asp Phe  Leu Thr Gln Ile Ser             
                1000                 1005                 1010            

aga agt ccc atg ctg  gac tgc tcc att gct  gac tgc ctg cag ttc         3124
Arg Ser Pro Met Leu  Asp Cys Ser Ile Ala  Asp Cys Leu Gln Phe             
                1015                 1020                 1025            

cgc tgt gac gtc ccc  tcc ttc agc gtc cag  gag gag ctg gat ttc         3169
Arg Cys Asp Val Pro  Ser Phe Ser Val Gln  Glu Glu Leu Asp Phe             
                1030                 1035                 1040            

acc ctg aag ggc aat  ctc agt ttc ggc tgg  gtc cgc gag aca ttg         3214
Thr Leu Lys Gly Asn  Leu Ser Phe Gly Trp  Val Arg Glu Thr Leu             
                1045                 1050                 1055            

cag aag aag gtg ttg  gtc gtg agt gtg gct  gaa att acg ttc gac         3259
Gln Lys Lys Val Leu  Val Val Ser Val Ala  Glu Ile Thr Phe Asp             
                1060                 1065                 1070            

aca tcc gtg tac tcc  cag ctt cca gga cag  gag gca ttt atg aga         3304
Thr Ser Val Tyr Ser  Gln Leu Pro Gly Gln  Glu Ala Phe Met Arg             
                1075                 1080                 1085            

gct cag atg gag atg  gtg cta gaa gaa gac  gag gtc tac aat gcc         3349
Ala Gln Met Glu Met  Val Leu Glu Glu Asp  Glu Val Tyr Asn Ala             
                1090                 1095                 1100            

att ccc atc atc atg  ggc agc tct gtg ggg  gct ctg cta ctg ctg         3394
Ile Pro Ile Ile Met  Gly Ser Ser Val Gly  Ala Leu Leu Leu Leu             
                1105                 1110                 1115            

gcg ctc atc aca gcc  aca ctg tac aag ctt  ggc ttc ttc aaa cgc         3439
Ala Leu Ile Thr Ala  Thr Leu Tyr Lys Leu  Gly Phe Phe Lys Arg             
                1120                 1125                 1130            

cac tac aag gaa atg  ctg gag gac aag cct  gaa gac act gcc aca         3484
His Tyr Lys Glu Met  Leu Glu Asp Lys Pro  Glu Asp Thr Ala Thr             
                1135                 1140                 1145            

ttc agt ggg gac gat  ttc agc tgt gtg gcc  cca aat gtg cct ttg         3529
Phe Ser Gly Asp Asp  Phe Ser Cys Val Ala  Pro Asn Val Pro Leu             
                1150                 1155                 1160            

tcc taa taatccactt tcctgtttat ctctaccact gtgggctgga cttgcttgca        3585
Ser                                                                       
                                                                          

accataaatc aacttacatg gaaacaactt ctgcatagat ctgcactggc ctaagcaacc     3645

taccaggtgc taagcacctt ctcggagaga tagagattgt aatgttttta catatctgtc     3705

catctttttc agcaatgacc cactttttac agaagcaggc atggtgccag cataaatttt     3765

catatgctta agaattgtca catgaaatga ggatgtttat agcacacttt ccttgcgtgg     3825

aagagctata acccagggac ctgagtgcct ctctgggaat agtcggggga acctatttgt     3885

gggcattgaa aaagtttttt cactttc                                         3912


<210>  298
<211>  1161
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Thr Phe Gly Thr Val Leu Leu Leu Ser Val Leu Ala Ser Tyr His 
1               5                   10                  15      


Gly Phe Asn Leu Asp Val Glu Glu Pro Thr Ile Phe Gln Glu Asp Ala 
            20                  25                  30          


Gly Gly Phe Gly Gln Ser Val Val Gln Phe Gly Gly Ser Arg Leu Val 
        35                  40                  45              


Val Gly Ala Pro Leu Glu Val Val Ala Ala Asn Gln Thr Gly Arg Leu 
    50                  55                  60                  


Tyr Asp Cys Ala Ala Ala Thr Gly Met Cys Gln Pro Ile Pro Leu His 
65                  70                  75                  80  


Ile Arg Pro Glu Ala Val Asn Met Ser Leu Gly Leu Thr Leu Ala Ala 
                85                  90                  95      


Ser Thr Asn Gly Ser Arg Leu Leu Ala Cys Gly Pro Thr Leu His Arg 
            100                 105                 110         


Val Cys Gly Glu Asn Ser Tyr Ser Lys Gly Ser Cys Leu Leu Leu Gly 
        115                 120                 125             


Ser Arg Trp Glu Ile Ile Gln Thr Val Pro Asp Ala Thr Pro Glu Cys 
    130                 135                 140                 


Pro His Gln Glu Met Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser 
145                 150                 155                 160 


Ile Asp Gln Asn Asp Phe Asn Gln Met Lys Gly Phe Val Gln Ala Val 
                165                 170                 175     


Met Gly Gln Phe Glu Gly Thr Asp Thr Leu Phe Ala Leu Met Gln Tyr 
            180                 185                 190         


Ser Asn Leu Leu Lys Ile His Phe Thr Phe Thr Gln Phe Arg Thr Ser 
        195                 200                 205             


Pro Ser Gln Gln Ser Leu Val Asp Pro Ile Val Gln Leu Lys Gly Leu 
    210                 215                 220                 


Thr Phe Thr Ala Thr Gly Ile Leu Thr Val Val Thr Gln Leu Phe His 
225                 230                 235                 240 


His Lys Asn Gly Ala Arg Lys Ser Ala Lys Lys Ile Leu Ile Val Ile 
                245                 250                 255     


Thr Asp Gly Gln Lys Tyr Lys Asp Pro Leu Glu Tyr Ser Asp Val Ile 
            260                 265                 270         


Pro Gln Ala Glu Lys Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly 
        275                 280                 285             


His Ala Phe Gln Gly Pro Thr Ala Arg Gln Glu Leu Asn Thr Ile Ser 
    290                 295                 300                 


Ser Ala Pro Pro Gln Asp His Val Phe Lys Val Asp Asn Phe Ala Ala 
305                 310                 315                 320 


Leu Gly Ser Ile Gln Lys Gln Leu Gln Glu Lys Ile Tyr Ala Val Glu 
                325                 330                 335     


Gly Thr Gln Ser Arg Ala Ser Ser Ser Phe Gln His Glu Met Ser Gln 
            340                 345                 350         


Glu Gly Phe Ser Thr Ala Leu Thr Met Asp Gly Leu Phe Leu Gly Ala 
        355                 360                 365             


Val Gly Ser Phe Ser Trp Ser Gly Gly Ala Phe Leu Tyr Pro Pro Asn 
    370                 375                 380                 


Met Ser Pro Thr Phe Ile Asn Met Ser Gln Glu Asn Val Asp Met Arg 
385                 390                 395                 400 


Asp Ser Tyr Leu Gly Tyr Ser Thr Glu Leu Ala Leu Trp Lys Gly Val 
                405                 410                 415     


Gln Asn Leu Val Leu Gly Ala Pro Arg Tyr Gln His Thr Gly Lys Ala 
            420                 425                 430         


Val Ile Phe Thr Gln Val Ser Arg Gln Trp Arg Lys Lys Ala Glu Val 
        435                 440                 445             


Thr Gly Thr Gln Ile Gly Ser Tyr Phe Gly Ala Ser Leu Cys Ser Val 
    450                 455                 460                 


Asp Val Asp Ser Asp Gly Ser Thr Asp Leu Ile Leu Ile Gly Ala Pro 
465                 470                 475                 480 


His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 
                485                 490                 495     


Pro Arg Gly Arg Val Gln Trp Gln Cys Asp Ala Val Leu Arg Gly Glu 
            500                 505                 510         


Gln Gly His Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu Gly 
        515                 520                 525             


Asp Val Asn Glu Asp Lys Leu Ile Asp Val Ala Ile Gly Ala Pro Gly 
    530                 535                 540                 


Glu Gln Glu Asn Arg Gly Ala Val Tyr Leu Phe His Gly Ala Ser Glu 
545                 550                 555                 560 


Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Ser Ser Gln Leu 
                565                 570                 575     


Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ala Leu Ser Gly Gly Gln Asp 
            580                 585                 590         


Leu Thr Gln Asp Gly Leu Met Asp Leu Ala Val Gly Ala Arg Gly Gln 
        595                 600                 605             


Val Leu Leu Leu Arg Ser Leu Pro Val Leu Lys Val Gly Val Ala Met 
    610                 615                 620                 


Arg Phe Ser Pro Val Glu Val Ala Lys Ala Val Tyr Arg Cys Trp Glu 
625                 630                 635                 640 


Glu Lys Pro Ser Ala Leu Glu Ala Gly Asp Ala Thr Val Cys Leu Thr 
                645                 650                 655     


Ile Gln Lys Ser Ser Leu Asp Gln Leu Gly Asp Ile Gln Ser Ser Val 
            660                 665                 670         


Arg Phe Asp Leu Ala Leu Asp Pro Gly Arg Leu Thr Ser Arg Ala Ile 
        675                 680                 685             


Phe Asn Glu Thr Lys Asn Pro Thr Leu Thr Arg Arg Lys Thr Leu Gly 
    690                 695                 700                 


Leu Gly Ile His Cys Glu Thr Leu Lys Leu Leu Leu Pro Asp Cys Val 
705                 710                 715                 720 


Glu Asp Val Val Ser Pro Ile Ile Leu His Leu Asn Phe Ser Leu Val 
                725                 730                 735     


Arg Glu Pro Ile Pro Ser Pro Gln Asn Leu Arg Pro Val Leu Ala Val 
            740                 745                 750         


Gly Ser Gln Asp Leu Phe Thr Ala Ser Leu Pro Phe Glu Lys Asn Cys 
        755                 760                 765             


Gly Gln Asp Gly Leu Cys Glu Gly Asp Leu Gly Val Thr Leu Ser Phe 
    770                 775                 780                 


Ser Gly Leu Gln Thr Leu Thr Val Gly Ser Ser Leu Glu Leu Asn Val 
785                 790                 795                 800 


Ile Val Thr Val Trp Asn Ala Gly Glu Asp Ser Tyr Gly Thr Val Val 
                805                 810                 815     


Ser Leu Tyr Tyr Pro Ala Gly Leu Ser His Arg Arg Val Ser Gly Ala 
            820                 825                 830         


Gln Lys Gln Pro His Gln Ser Ala Leu Arg Leu Ala Cys Glu Thr Val 
        835                 840                 845             


Pro Thr Glu Asp Glu Gly Leu Arg Ser Ser Arg Cys Ser Val Asn His 
    850                 855                 860                 


Pro Ile Phe His Glu Gly Ser Asn Gly Thr Phe Ile Val Thr Phe Asp 
865                 870                 875                 880 


Val Ser Tyr Lys Ala Thr Leu Gly Asp Arg Met Leu Met Arg Ala Ser 
                885                 890                 895     


Ala Ser Ser Glu Asn Asn Lys Ala Ser Ser Ser Lys Ala Thr Phe Gln 
            900                 905                 910         


Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Thr Met Ile Ser Arg Gln 
        915                 920                 925             


Glu Glu Ser Thr Lys Tyr Phe Asn Phe Ala Thr Ser Asp Glu Lys Lys 
    930                 935                 940                 


Met Lys Glu Ala Glu His Arg Tyr Arg Val Asn Asn Leu Ser Gln Arg 
945                 950                 955                 960 


Asp Leu Ala Ile Ser Ile Asn Phe Trp Val Pro Val Leu Leu Asn Gly 
                965                 970                 975     


Val Ala Val Trp Asp Val Val Met Glu Ala Pro Ser Gln Ser Leu Pro 
            980                 985                 990         


Cys Val Ser Glu Arg Lys Pro Pro  Gln His Ser Asp Phe  Leu Thr Gln 
        995                 1000                 1005             


Ile Ser  Arg Ser Pro Met Leu  Asp Cys Ser Ile Ala  Asp Cys Leu 
    1010                 1015                 1020             


Gln Phe  Arg Cys Asp Val Pro  Ser Phe Ser Val Gln  Glu Glu Leu 
    1025                 1030                 1035             


Asp Phe  Thr Leu Lys Gly Asn  Leu Ser Phe Gly Trp  Val Arg Glu 
    1040                 1045                 1050             


Thr Leu  Gln Lys Lys Val Leu  Val Val Ser Val Ala  Glu Ile Thr 
    1055                 1060                 1065             


Phe Asp  Thr Ser Val Tyr Ser  Gln Leu Pro Gly Gln  Glu Ala Phe 
    1070                 1075                 1080             


Met Arg  Ala Gln Met Glu Met  Val Leu Glu Glu Asp  Glu Val Tyr 
    1085                 1090                 1095             


Asn Ala  Ile Pro Ile Ile Met  Gly Ser Ser Val Gly  Ala Leu Leu 
    1100                 1105                 1110             


Leu Leu  Ala Leu Ile Thr Ala  Thr Leu Tyr Lys Leu  Gly Phe Phe 
    1115                 1120                 1125             


Lys Arg  His Tyr Lys Glu Met  Leu Glu Asp Lys Pro  Glu Asp Thr 
    1130                 1135                 1140             


Ala Thr  Phe Ser Gly Asp Asp  Phe Ser Cys Val Ala  Pro Asn Val 
    1145                 1150                 1155             


Pro Leu  Ser 
    1160     


<210>  299
<211>  3241
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (124)..(2736)

<400>  299
gaggcggcag ctgcgcggcg gcaccggggc ggctgcggcg cgctcggagc cccgagggca       60

cgcggcccgg gcagctcggt gtgcgccccc gcgagagccg gggccccagg cccgccggac      120

acc atg aac cac ctg aac gtg ctg gcc aaa gcg ctc tat gac aat gtg        168
    Met Asn His Leu Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val           
    1               5                   10                  15            

gcc gag tcc ccg gat gag ctc tcc ttc cgc aag ggt gac atc atg acg        216
Ala Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr           
                20                  25                  30                

gtg ctg gag cag gac acg cag ggc ctg gac ggc tgg tgg ctc tgc tcg        264
Val Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser           
            35                  40                  45                    

ctg cat ggg cgc cag ggc atc gtg cct ggg aac cgc ctc aag atc ttg        312
Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu           
        50                  55                  60                        

gtg ggc atg tat gat aag aag cca gca ggg cct ggc ccc ggc cct ccc        360
Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro Pro           
    65                  70                  75                            

gcc acc ccg gcc cag cct cag cct ggc ctc cat gcc cca gcg cct ccg        408
Ala Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro           
80                  85                  90                  95            

gcc tcc cag tac acg ccc atg ctc ccc aac acc tac cag ccc cag cca        456
Ala Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro Gln Pro           
                100                 105                 110               

gac agc gtc tac ctg gtg ccc act ccc agc aag gct cag caa ggc ctc        504
Asp Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln Gly Leu           
            115                 120                 125                   

tac caa gtc ccg ggt ccc agc cct cag ttc cag tct ccc cca gcc aag        552
Tyr Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys           
        130                 135                 140                       

cag aca tcc acc ttc tcg aag cag aca ccc cat cac ccg ttt ccc agc        600
Gln Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Pro Phe Pro Ser           
    145                 150                 155                           

ccg gcc aca gac ctg tac cag gtg ccc cca ggg cct gga ggc cct gcc        648
Pro Ala Thr Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala           
160                 165                 170                 175           

cag gat att tac cag gtg cca cct tct gcc ggg atg ggg cat gac atc        696
Gln Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile           
                180                 185                 190               

tac cag gtc ccc ccg tcc atg gac aca cgc agc tgg gag ggc acg aag        744
Tyr Gln Val Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr Lys           
            195                 200                 205                   

ccc ccg gca aag gtg gtg gtg ccc acc cgc gtg ggg cag ggc tat gta        792
Pro Pro Ala Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr Val           
        210                 215                 220                       

tac gag gcc gcc cag ccg gag cag gac gag tac gac atc ccg cga cac        840
Tyr Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His           
    225                 230                 235                           

ctg ctg gcc ccg ggg cca cag gac atc tat gat gtg ccc ccg gtt cgg        888
Leu Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg           
240                 245                 250                 255           

ggg ctg ctt ccc agc cag tat ggc cag gag gtg tat gac aca ccc ccc        936
Gly Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro Pro           
                260                 265                 270               

atg gct gtc aag ggt ccc aat ggc cga gac ccg ttg ctg gag gtg tat        984
Met Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr           
            275                 280                 285                   

gac gtg ccc ccc agt gtg gag aag ggc ctg cca ccg tcc aac cac cac       1032
Asp Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His           
        290                 295                 300                       

gca gtc tac gac gtt cct cca tcg gtg agc aag gat gtg ccc gat ggc       1080
Ala Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly           
    305                 310                 315                           

cca ctg ctg cgt gag gag acc tac gat gtg ccc ccc gcc ttc gcc aag       1128
Pro Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala Lys           
320                 325                 330                 335           

gcc aag ccc ttt gac ccg gcc cgc acc cca ctg gta ctg gct gcg ccc       1176
Ala Lys Pro Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Ala Ala Pro           
                340                 345                 350               

cct cca gac tcc ccg ccg gcc gag gac gtg tat gac gtg ccg ccc ccg       1224
Pro Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro           
            355                 360                 365                   

gct cct gac ctc tac gac gtg ccc cct ggc ttg cgg cgg cct ggc ccg       1272
Ala Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro           
        370                 375                 380                       

ggc acc ctg tac gat gtg ccc cgt gaa cgg gtg ctt cct cct gag gtg       1320
Gly Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val           
    385                 390                 395                           

gct gat ggt ggc gtg gtc gac agt ggt gtg tat gcg gtg cct ccc cca       1368
Ala Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro           
400                 405                 410                 415           

gct gaa cgt gaa gcc ccg gca gag ggc aag cgc ctg tcg gcc tcc agc       1416
Ala Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser           
                420                 425                 430               

acc ggc agc aca cgc agc agc cag tct gcg tcc tcc ttg gag gtg gca       1464
Thr Gly Ser Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala           
            435                 440                 445                   

ggg ccg ggc cgg gaa ccc ctg gag ctg gaa gtt gct gtg gag gcc ctg       1512
Gly Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu           
        450                 455                 460                       

gca cgg ctg cag cag ggt gtg agc gcc acc gtt gcc cac ctt ctg gac       1560
Ala Arg Leu Gln Gln Gly Val Ser Ala Thr Val Ala His Leu Leu Asp           
    465                 470                 475                           

ctg gca ggc agc gcc ggt gcg act ggg agc tgg cgt agc ccc tct gag       1608
Leu Ala Gly Ser Ala Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser Glu           
480                 485                 490                 495           

cca cag gag ccg ctg gtg cag gac ctg cag gct gct gtg gcc gct gtc       1656
Pro Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val           
                500                 505                 510               

cag agt gcc gtc cac gag ctg ttg gag ttt gcc cgc agc gcg gtg ggc       1704
Gln Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly           
            515                 520                 525                   

aat gct gcc cac aca tct gac cgt gcc ctg cat gcc aag ctt agc cgg       1752
Asn Ala Ala His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg           
        530                 535                 540                       

cag ctg cag aag atg gag gac gtg cac cag acg ctg gtg gca cat ggt       1800
Gln Leu Gln Lys Met Glu Asp Val His Gln Thr Leu Val Ala His Gly           
    545                 550                 555                           

cag gcc ctc gac gct ggc cgg gga ggc tct gga gcc acc ctt gag gac       1848
Gln Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu Asp           
560                 565                 570                 575           

ctg gac cgg ctg gtg gcc tgc tcg cgg gct gtg ccc gag gac gcc aag       1896
Leu Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys           
                580                 585                 590               

cag ctg gcc tcc ttc ctg cac ggc aat gcc tca ctg ctc ttc aga cgg       1944
Gln Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg           
            595                 600                 605                   

acc aag gcc act gcc ccg ggg cct gag ggg ggt ggc acc ctg cac ccc       1992
Thr Lys Ala Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His Pro           
        610                 615                 620                       

aac ccc act gac aag acc agc agc atc cag tca cga ccc ctg ccc tca       2040
Asn Pro Thr Asp Lys Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser           
    625                 630                 635                           

ccc cct aag ttc acc tcc cag gac tcg cca gat ggg cag tac gag aac       2088
Pro Pro Lys Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn           
640                 645                 650                 655           

agc gag ggg ggc tgg atg gag gac tat gac tac gtc cac cta cag ggg       2136
Ser Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly           
                660                 665                 670               

aag gag gag ttt gag aag acc cag aag gag ctg ctg gaa aag ggc agc       2184
Lys Glu Glu Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly Ser           
            675                 680                 685                   

atc acg cgg cag ggc aag agc cag ctg gag ttg cag cag ctg aag cag       2232
Ile Thr Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln           
        690                 695                 700                       

ttt gaa cga ctg gaa cag gag gtg tca cgg ccc ata gac cac gac ctg       2280
Phe Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu           
    705                 710                 715                           

gcc aac tgg acg cca gcc caa ccc ctg gcc ccg ggg cga aca ggc ggc       2328
Ala Asn Trp Thr Pro Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly Gly           
720                 725                 730                 735           

ctg ggg ccc tcg gac cgg cag ctg ctg ctc ttc tac ctg gag cag tgt       2376
Leu Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys           
                740                 745                 750               

gag gcc aac ctg acc aca ctg acc aac gcc gtg gac gcc ttc ttt acc       2424
Glu Ala Asn Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe Thr           
            755                 760                 765                   

gcc gtg gcc acc aac cag ccg ccc aag atc ttt gtg gcg cac agc aag       2472
Ala Val Ala Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys           
        770                 775                 780                       

ttc gtc atc ctc agc gcc cac aag ctg gtg ttc atc ggg gac aca ctg       2520
Phe Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu           
    785                 790                 795                           

tca cgg cag gcc aag gct gct gac gtg cgc agc cag gtg acc cac tac       2568
Ser Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Thr His Tyr           
800                 805                 810                 815           

agc aac ctg ctg tgc gac ctc ctg cgc ggc atc gtg gcc acc acc aag       2616
Ser Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr Lys           
                820                 825                 830               

gcc gct gcc ttg cag tac cca tcg cct tcc gcg gcc cag gac atg gtg       2664
Ala Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val           
            835                 840                 845                   

gag agg gtc aag gag ctg ggc cac agc acc cag cag ttc cgc cgc gtc       2712
Glu Arg Val Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg Val           
        850                 855                 860                       

cta ggc cag ctg gca gcc gcc tga gggtggtgac cccaggaggg aggcagggga      2766
Leu Gly Gln Leu Ala Ala Ala                                               
    865                 870                                               

ggggtgcggc ggtcccagct ccctggctcc catgtcaaga gtcgctgtgc cacaggctta     2826

gggacaggac cccagctctg cgtcggtcct ggtgccctgg atgcccagga atctgtatat     2886

atttatggcc gggcagggtg tggggccatg cctcctcagg agccgaagcc caggggccgg     2946

ccagtggcct tccccagcat gcaccacggg cccgggttgg gtcaccagac ggggctggag     3006

tgtgagggtc ctgcagcctg caggacctcg tgccaccccg agggctgagc ctggtcccac     3066

gagggtgccg tgtcccctga cagggccagt gcagtttggt gtgtcctccg ccttaccagg     3126

agaagaacct gaagaactat ttttcgttat tggttttcca atcatttgac taagagtctc     3186

catttaaata aagtttttaa aaggaagagc aaaaaaaaaa aaaaaaaaaa aaaaa          3241


<210>  300
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Asn His Leu Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala 
1               5                   10                  15      


Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr Val 
            20                  25                  30          


Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45              


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val 
    50                  55                  60                  


Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro Pro Ala 
65                  70                  75                  80  


Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala 
                85                  90                  95      


Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro Gln Pro Asp 
            100                 105                 110         


Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln Gly Leu Tyr 
        115                 120                 125             


Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln 
    130                 135                 140                 


Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Pro Phe Pro Ser Pro 
145                 150                 155                 160 


Ala Thr Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln 
                165                 170                 175     


Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr 
            180                 185                 190         


Gln Val Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr Lys Pro 
        195                 200                 205             


Pro Ala Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr Val Tyr 
    210                 215                 220                 


Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu 
225                 230                 235                 240 


Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly 
                245                 250                 255     


Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro Pro Met 
            260                 265                 270         


Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp 
        275                 280                 285             


Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala 
    290                 295                 300                 


Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro 
305                 310                 315                 320 


Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala 
                325                 330                 335     


Lys Pro Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Ala Ala Pro Pro 
            340                 345                 350         


Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala 
        355                 360                 365             


Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly 
    370                 375                 380                 


Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala 
385                 390                 395                 400 


Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala 
                405                 410                 415     


Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Thr 
            420                 425                 430         


Gly Ser Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly 
        435                 440                 445             


Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala 
    450                 455                 460                 


Arg Leu Gln Gln Gly Val Ser Ala Thr Val Ala His Leu Leu Asp Leu 
465                 470                 475                 480 


Ala Gly Ser Ala Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser Glu Pro 
                485                 490                 495     


Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln 
            500                 505                 510         


Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn 
        515                 520                 525             


Ala Ala His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln 
    530                 535                 540                 


Leu Gln Lys Met Glu Asp Val His Gln Thr Leu Val Ala His Gly Gln 
545                 550                 555                 560 


Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu Asp Leu 
                565                 570                 575     


Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln 
            580                 585                 590         


Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Thr 
        595                 600                 605             


Lys Ala Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His Pro Asn 
    610                 615                 620                 


Pro Thr Asp Lys Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro 
625                 630                 635                 640 


Pro Lys Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser 
                645                 650                 655     


Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys 
            660                 665                 670         


Glu Glu Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile 
        675                 680                 685             


Thr Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe 
    690                 695                 700                 


Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala 
705                 710                 715                 720 


Asn Trp Thr Pro Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly Gly Leu 
                725                 730                 735     


Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu 
            740                 745                 750         


Ala Asn Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe Thr Ala 
        755                 760                 765             


Val Ala Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe 
    770                 775                 780                 


Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Ser 
785                 790                 795                 800 


Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Thr His Tyr Ser 
                805                 810                 815     


Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr Lys Ala 
            820                 825                 830         


Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu 
        835                 840                 845             


Arg Val Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg Val Leu 
    850                 855                 860                 


Gly Gln Leu Ala Ala Ala 
865                 870 


<210>  301
<211>  5044
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (465)..(3620)

<400>  301
tttccccgga aggaaagcgc agcccgggct gggctcgcaa ggtggggagg tgcgggactg       60

ggcgtgggga ggcggggcgc gcgccggggg acccctccct cctgtcctcc ttgcggtcga      120

ccggtgcgct tgccagatcc gccgcgaagc cgggatcgaa ggcgacagcg cggccaaggg      180

ggcgcggccg ggacaagctg ggggccggtt gcccggggca gggacggcgg cgacccggcc      240

gctggggagg caggaagata gacccacgga tcttaggaag ggatccgaga gcgcagctgt      300

gaaactggct ggggctgggg gcacgaaacc gatcagcgct acggagcgca gcggccggcg      360

ggttccagtg tcctccggcg gcgcggggag caggtgaaca ggtcctcacg cccagctccg      420

cgccctcacg cgctctcgcc gggaccccgc ttccgctggc agcc atg ggc ccc ggc       476
                                                 Met Gly Pro Gly          
                                                 1                        

ccc agc cgc gcg ccc cgc gcc cca cgc ctg atg ctc tgt gcg ctc gcc        524
Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu Cys Ala Leu Ala           
5                   10                  15                  20            

ttg atg gtg gcg gcc ggc ggc tgc gtc gtc tcc gcc ttc aac ctg gat        572
Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala Phe Asn Leu Asp           
                25                  30                  35                

acc cga ttc ctg gta gtg aag gag gcc ggg aac ccg ggc agc ctc ttc        620
Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro Gly Ser Leu Phe           
            40                  45                  50                    

ggc tac tcg gtc gcc ctc cat cgg cag aca gag cgg cag cag cgc tac        668
Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg Gln Gln Arg Tyr           
        55                  60                  65                        

ctg ctc ctg gct ggt gcc ccc cgg gag ctc gct gtg ccc gat ggc tac        716
Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val Pro Asp Gly Tyr           
    70                  75                  80                            

acc aac cgg act ggt gct gtg tac ctg tgc cca ctc act gcc cac aag        764
Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu Thr Ala His Lys           
85                  90                  95                  100           

gat gac tgt gag cgg atg aac atc aca gtg aaa aat gac cct ggc cat        812
Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn Asp Pro Gly His           
                105                 110                 115               

cac att att gag gac atg tgg ctt gga gtg act gtg gcc agc cag ggc        860
His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val Ala Ser Gln Gly           
            120                 125                 130                   

cct gca ggc aga gtt ctg gtc tgt gcc cac cgc tac acc cag gtg ctg        908
Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr Thr Gln Val Leu           
        135                 140                 145                       

tgg tca ggg tca gaa gac cag cgg cgc atg gtg ggc aag tgc tac gtg        956
Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly Lys Cys Tyr Val           
    150                 155                 160                           

cga ggc aat gac cta gag ctg gac tcc agt gat gac tgg cag acc tac       1004
Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp Trp Gln Thr Tyr           
165                 170                 175                 180           

cac aac gag atg tgc aat agc aac aca gac tac ctg gag acg ggc atg       1052
His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu Glu Thr Gly Met           
                185                 190                 195               

tgc cag ctg ggc acc agc ggt ggc ttc acc cag aac act gtg tac ttc       1100
Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn Thr Val Tyr Phe           
            200                 205                 210                   

ggc gcc ccc ggt gcc tac aac tgg aaa gga aac agc tac atg att cag       1148
Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser Tyr Met Ile Gln           
        215                 220                 225                       

cgc aag gag tgg gac tta tct gag tat agt tac aag gac cca gag gac       1196
Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys Asp Pro Glu Asp           
    230                 235                 240                           

caa gga aac ctc tat att ggg tac acg atg cag gta ggc agc ttc atc       1244
Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val Gly Ser Phe Ile           
245                 250                 255                 260           

ctg cac ccc aaa aac atc acc att gtg aca ggt gcc cca cgg cac cga       1292
Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala Pro Arg His Arg           
                265                 270                 275               

cat atg ggc gcg gtg ttc ttg ctg agc cag gag gca ggc gga gac ctg       1340
His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala Gly Gly Asp Leu           
            280                 285                 290                   

cgg agg agg cag gtg ctg gag ggc tcg cag gtg ggc gcc tat ttt ggc       1388
Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly Ala Tyr Phe Gly           
        295                 300                 305                       

agc gcc att gcc ctg gca gac ctg aac aat gat ggg tgg cag gac ctc       1436
Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly Trp Gln Asp Leu           
    310                 315                 320                           

ctg gtg ggc gcc ccc tac tac ttc gag agg aaa gag gaa gta ggg ggt       1484
Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu Glu Val Gly Gly           
325                 330                 335                 340           

gcc atc tat gtc ttc atg aac cag gcg gga acc tcc ttc cct gct cac       1532
Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser Phe Pro Ala His           
                345                 350                 355               

ccc tca ctc ctt ctt cat ggc ccc agt ggc tct gcc ttt ggt tta tct       1580
Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala Phe Gly Leu Ser           
            360                 365                 370                   

gtg gcc agc att ggt gac atc aac cag gat gga ttt cag gat att gct       1628
Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe Gln Asp Ile Ala           
        375                 380                 385                       

gtg gga gct ccg ttt gaa ggc ttg ggc aaa gtg tac atc tat cac agt       1676
Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr Ile Tyr His Ser           
    390                 395                 400                           

agc tct aag ggg ctc ctt aga cag ccc cag cag gta atc cat gga gag       1724
Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val Ile His Gly Glu           
405                 410                 415                 420           

aag ctg gga ctg cct ggg ttg gcc acc ttc ggc tat tcc ctc agt ggg       1772
Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr Ser Leu Ser Gly           
                425                 430                 435               

cag atg gat gtg gat gag aac ttc tac cca gac ctt cta gtg gga agc       1820
Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu Leu Val Gly Ser           
            440                 445                 450                   

ctg tca gac cac att gtg ctg ctg cgg gcc cgg ccc gtc atc aac atc       1868
Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro Val Ile Asn Ile           
        455                 460                 465                       

gtc cac aag acc ttg gtg ccc agg cca gct gtg ctg gac cct gca ctt       1916
Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu Asp Pro Ala Leu           
    470                 475                 480                           

tgc acg gcc acc tct tgt gtg caa gtg gag ctg tgc ttt gct tac aac       1964
Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys Phe Ala Tyr Asn           
485                 490                 495                 500           

cag agt gcc ggg aac ccc aac tac agg cga aac atc acc ctg gcc tac       2012
Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile Thr Leu Ala Tyr           
                505                 510                 515               

act ctg gag gct gac agg gac cgc cgg ccg ccc cgg ctc cgc ttt gcc       2060
Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg Leu Arg Phe Ala           
            520                 525                 530                   

ggc agt gag tcc gct gtc ttc cac ggc ttc ttc tcc atg ccc gag atg       2108
Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser Met Pro Glu Met           
        535                 540                 545                       

cgc tgc cag aag ctg gag ctg ctc ctg atg gac aac ctc cgt gac aaa       2156
Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn Leu Arg Asp Lys           
    550                 555                 560                           

ctc cgc ccc atc atc atc tcc atg aac tac tct tta cct ttg cgg atg       2204
Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu Pro Leu Arg Met           
565                 570                 575                 580           

ccc gat cgc ccc cgg ctg ggg ctg cgg tcc ctg gac gcc tac ccg atc       2252
Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp Ala Tyr Pro Ile           
                585                 590                 595               

ctc aac cag gca cag gct ctg gag aac cac act gag gtc cag ttc cag       2300
Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu Val Gln Phe Gln           
            600                 605                 610                   

aag gag tgc ggg cct gac aac aag tgt gag agc aac ttg cag atg cgg       2348
Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn Leu Gln Met Arg           
        615                 620                 625                       

gca gcc ttc gtg tca gag cag cag cag aag ctg agc agg ctc cag tac       2396
Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser Arg Leu Gln Tyr           
    630                 635                 640                           

agc aga gac gtc cgg aaa ttg ctc ctg agc atc aac gtg acg aac acc       2444
Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn Val Thr Asn Thr           
645                 650                 655                 660           

cgg acc tcg gag cgc tcc ggg gag gac gcc cac gag gcg ctg ctc acc       2492
Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu Ala Leu Leu Thr           
                665                 670                 675               

ctg gtg gtg cct ccc gcc ctg ctg ctg tcc tca gtg cgc ccc ccc ggg       2540
Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val Arg Pro Pro Gly           
            680                 685                 690                   

gcc tgc caa gct aat gag acc atc ttt tgc gag ctg ggg aac ccc ttc       2588
Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu Gly Asn Pro Phe           
        695                 700                 705                       

aaa cgg aac cag agg atg gag ctg ctc atc gcc ttt gag gtc atc ggg       2636
Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe Glu Val Ile Gly           
    710                 715                 720                           

gtg acc ctg cac aca agg gac ctt cag gtg cag ctg cag ctc tcc acg       2684
Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu Gln Leu Ser Thr           
725                 730                 735                 740           

tcg agt cac cag gac aac ctg tgg ccc atg atc ctc act ctg ctg gtg       2732
Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu Thr Leu Leu Val           
                745                 750                 755               

gac tat aca ctc cag acc tcg ctt agc atg gta aat cac cgg cta caa       2780
Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn His Arg Leu Gln           
            760                 765                 770                   

agc ttc ttt ggg ggg aca gtg atg ggt gag tct ggc atg aaa act gtg       2828
Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly Met Lys Thr Val           
        775                 780                 785                       

gag gat gta gga agc ccc ctc aag tat gaa ttc cag gtg ggc cca atg       2876
Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln Val Gly Pro Met           
    790                 795                 800                           

ggg gag ggg ctg gtg ggc ctg ggg acc ctg gtc cta ggt ctg gag tgg       2924
Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu Gly Leu Glu Trp           
805                 810                 815                 820           

ccc tac gaa gtc agc aat ggc aag tgg ctg ctg tat ccc acg gag atc       2972
Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr Pro Thr Glu Ile           
                825                 830                 835               

acc gtc cat ggc aat ggg tcc tgg ccc tgc cga cca cct gga gac ctt       3020
Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro Pro Gly Asp Leu           
            840                 845                 850                   

atc aac cct ctc aac ctc act ctt tct gac cct ggg gac agg cca tca       3068
Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly Asp Arg Pro Ser           
        855                 860                 865                       

tcc cca cag cgc agg cgg cga cag ctg gat cca ggg gga ggc cag ggc       3116
Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly Gly Gly Gln Gly           
    870                 875                 880                           

ccc cca cct gtc act ctg gct gct gcc aaa aaa gcc aag tct gag act       3164
Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala Lys Ser Glu Thr           
885                 890                 895                 900           

gtg ctg acc tgt gcc aca ggg cgt gcc cac tgt gtg tgg cta gag tgc       3212
Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val Trp Leu Glu Cys           
                905                 910                 915               

ccc atc cct gat gcc ccc gtt gtc acc aac gtg act gtg aag gca cga       3260
Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr Val Lys Ala Arg           
            920                 925                 930                   

gtg tgg aac agc acc ttc atc gag gat tac aga gac ttt gac cga gtc       3308
Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp Phe Asp Arg Val           
        935                 940                 945                       

cgg gta aat ggc tgg gct acc cta ttc ctc cga acc agc atc ccc acc       3356
Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr Ser Ile Pro Thr           
    950                 955                 960                           

atc aac atg gag aac aag acc acg tgg ttc tct gtg gac att gac tcg       3404
Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val Asp Ile Asp Ser           
965                 970                 975                 980           

gag ctg gtg gag gag ctg ccg gcc gaa atc gag ctg tgg ctg gtg ctg       3452
Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu Trp Leu Val Leu           
                985                 990                 995               

gtg gcc gtg ggt  gca ggg ctg ctg ctg  ctg ggg ctg atc atc  ctc        3497
Val Ala Val Gly  Ala Gly Leu Leu Leu  Leu Gly Leu Ile Ile  Leu            
            1000                 1005                 1010                

ctg ctg tgg aag  tgc ggc ttc ttc aag  cga gcc cgc act cgc  gcc        3542
Leu Leu Trp Lys  Cys Gly Phe Phe Lys  Arg Ala Arg Thr Arg  Ala            
            1015                 1020                 1025                

ctg tat gaa gct  aag agg cag aag gcg  gag atg aag agc cag  ccg        3587
Leu Tyr Glu Ala  Lys Arg Gln Lys Ala  Glu Met Lys Ser Gln  Pro            
            1030                 1035                 1040                

tca gag aca gag  agg ctg acc gac gac  tac tga gggggcagcc              3630
Ser Glu Thr Glu  Arg Leu Thr Asp Asp  Tyr                                 
            1045                 1050                                     

ccccgccccc ggcccacctg gtgtgacttc tttaagcgga cccgctatta tcagatcatg     3690

cccaagtacc acgcagtgcg gatccgggag gaggagcgct acccacctcc agggagcacc     3750

ctgcccacca agaagcactg ggtgaccagc tggcagactc gggaccaata ctactgacgt     3810

cctccctgat cccaccccct cctcccccag tgtccccttt cttcctattt atcataagtt     3870

atgcctctga cagtccacag gggccaccac ctttggctgg tagcagcagg ctcaggcaca     3930

tacacctcgt caagagcatg cacatgctgt ctggccctgg ggatcttccc acaggagggc     3990

cagcgctgtg gaccttacaa cgccgagtgc actgcattcc tgtgccctag atgcacgtgg     4050

ggcccactgc tcgtggactg tgctggtgca tcacggatgg tgcatgggct cgccgtgtct     4110

cagcctctgc cagcgccaaa acaagccaaa gagcctccca ccagagccgg gaggaaaagg     4170

cccctgcaat gtggtgacac ctcccccttt cacactggat ccatcttgag ccacagtcac     4230

tggattgact ttgctgtcaa aactactgac agggagcagc ccccgggccg ctggctggtg     4290

ggcccccaat gacacccatg ccagagaggt ggggatcctg cctaaggttg tctacggggg     4350

cacttggagg acctggcgtg ctcagaccca acagcaaagg aactagaaag aaggacccag     4410

aacggcttgc tttcctgcat ctctgtgaag cctctctcct tggccacaga ctgaactcgc     4470

agggaatgca gcaggaagga acaaagacag gcaaacggca acgtagcctg ggctcactgt     4530

gctggggcac ggcgggatcc tccacagaga ggaggggacc aattctggac agacagatgt     4590

tgggaggata cagaggagat gccacttctc actcaccact accagccagc ctcagaaggc     4650

cccagagaga ccctgcaaga ccacggaggg agcgacactt gaatgtagaa taggcagggg     4710

gccctgcccc accccatcca gccagacccc acgctgacca tgcgtcaggg gcctagaggt     4770

ggagttctta gctatccttg gctttcagag ccagcctggc tctgccccct cccccatggg     4830

ctgtgtccta aggcccattt gagaagctga ggctagttcc agaaaacctc tcctgacccc     4890

tgcctgttgg caggcccact ccccagcccc agccccttcc atggtactgt agcaggggaa     4950

ttccctcccc ctccttgtgc cttctttgta tataggcttc tcacggcgac caataaacag     5010

ctcccagttt gtatgcaaaa aaaaaaaaaa aaaa                                 5044


<210>  302
<211>  1051
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu 
1               5                   10                  15      


Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala 
            20                  25                  30          


Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro 
        35                  40                  45              


Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg 
    50                  55                  60                  


Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val 
65                  70                  75                  80  


Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu 
                85                  90                  95      


Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn 
            100                 105                 110         


Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val 
        115                 120                 125             


Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr 
    130                 135                 140                 


Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly 
145                 150                 155                 160 


Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp 
                165                 170                 175     


Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu 
            180                 185                 190         


Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn 
        195                 200                 205             


Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser 
    210                 215                 220                 


Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys 
225                 230                 235                 240 


Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val 
                245                 250                 255     


Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala 
            260                 265                 270         


Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala 
        275                 280                 285             


Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly 
    290                 295                 300                 


Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly 
305                 310                 315                 320 


Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu 
                325                 330                 335     


Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser 
            340                 345                 350         


Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala 
        355                 360                 365             


Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe 
    370                 375                 380                 


Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr 
385                 390                 395                 400 


Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val 
                405                 410                 415     


Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr 
            420                 425                 430         


Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu 
        435                 440                 445             


Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro 
    450                 455                 460                 


Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu 
465                 470                 475                 480 


Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys 
                485                 490                 495     


Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile 
            500                 505                 510         


Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg 
        515                 520                 525             


Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser 
    530                 535                 540                 


Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn 
545                 550                 555                 560 


Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu 
                565                 570                 575     


Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp 
            580                 585                 590         


Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu 
        595                 600                 605             


Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn 
    610                 615                 620                 


Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser 
625                 630                 635                 640 


Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn 
                645                 650                 655     


Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu 
            660                 665                 670         


Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val 
        675                 680                 685             


Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu 
    690                 695                 700                 


Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe 
705                 710                 715                 720 


Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu 
                725                 730                 735     


Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu 
            740                 745                 750         


Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn 
        755                 760                 765             


His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly 
    770                 775                 780                 


Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln 
785                 790                 795                 800 


Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu 
                805                 810                 815     


Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr 
            820                 825                 830         


Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro 
        835                 840                 845             


Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly 
    850                 855                 860                 


Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly 
865                 870                 875                 880 


Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala 
                885                 890                 895     


Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val 
            900                 905                 910         


Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr 
        915                 920                 925             


Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp 
    930                 935                 940                 


Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr 
945                 950                 955                 960 


Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val 
                965                 970                 975     


Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu 
            980                 985                 990         


Trp Leu Val Leu Val Ala Val Gly  Ala Gly Leu Leu Leu  Leu Gly Leu 
        995                 1000                 1005             


Ile Ile  Leu Leu Leu Trp Lys  Cys Gly Phe Phe Lys  Arg Ala Arg 
    1010                 1015                 1020             


Thr Arg  Ala Leu Tyr Glu Ala  Lys Arg Gln Lys Ala  Glu Met Lys 
    1025                 1030                 1035             


Ser Gln  Pro Ser Glu Thr Glu  Arg Leu Thr Asp Asp  Tyr 
    1040                 1045                 1050     


<210>  303
<211>  1191
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (242)..(739)

<400>  303
ggggaggaag gaggtgaggc ggtaaggggc gttctctctc ttgggtcccg cgcccaactt       60

ccgctggccc aaagaaacta taattttgaa ccaacagacc tctgctggca tctgcgattg      120

catttttcct gttttaacaa cggctgtgct agacgaagtg gtgaagccca aagacttatt      180

tttgagctcg ctgtaagact gagaaatcac gtagtccttc ctgaaaccac taagaggaaa      240

a atg tct gtg aca ctg cat aca gat gta ggt gat att aaa att gaa gtc      289
  Met Ser Val Thr Leu His Thr Asp Val Gly Asp Ile Lys Ile Glu Val         
  1               5                   10                  15              

ttc tgt gag agg aca ccc aaa aca tgt gag atg gag tct cgc tgt gtc        337
Phe Cys Glu Arg Thr Pro Lys Thr Cys Glu Met Glu Ser Arg Cys Val           
            20                  25                  30                    

ccc cag gct gga gta caa tgg cgc gat ctc ggc tca ctg caa cct ccg        385
Pro Gln Ala Gly Val Gln Trp Arg Asp Leu Gly Ser Leu Gln Pro Pro           
        35                  40                  45                        

cct cct ggg ttc aag caa gtc ttc tgc ctc agc ctc ccg aga act gga        433
Pro Pro Gly Phe Lys Gln Val Phe Cys Leu Ser Leu Pro Arg Thr Gly           
    50                  55                  60                            

aga gga ggc aac agt att tgg ggc aag aag ttt gag gat gaa tac agt        481
Arg Gly Gly Asn Ser Ile Trp Gly Lys Lys Phe Glu Asp Glu Tyr Ser           
65                  70                  75                  80            

gaa tat ctt aag cac aat gtt aga ggt gtt gta tct atg gct aat aat        529
Glu Tyr Leu Lys His Asn Val Arg Gly Val Val Ser Met Ala Asn Asn           
                85                  90                  95                

ggc ccg aac acc aat gga tct cag ttc ttc atc acc tat ggc aaa cag        577
Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Thr Tyr Gly Lys Gln           
            100                 105                 110                   

cca cat ttg gac atg aaa tac acc gta ttt gga aag gta ata gat ggt        625
Pro His Leu Asp Met Lys Tyr Thr Val Phe Gly Lys Val Ile Asp Gly           
        115                 120                 125                       

ctg gaa act cta gat gag ttg gag aag ttg cca gta aat gag aag aca        673
Leu Glu Thr Leu Asp Glu Leu Glu Lys Leu Pro Val Asn Glu Lys Thr           
    130                 135                 140                           

tac cga cct ctt aat gat gta cac att aag gac ata act att cat gcc        721
Tyr Arg Pro Leu Asn Asp Val His Ile Lys Asp Ile Thr Ile His Ala           
145                 150                 155                 160           

aac cca ttt gct cag tag ctatgataga cctggacaaa taacttgaca               769
Asn Pro Phe Ala Gln                                                       
                165                                                       

aattgctgga acacacttat tgtggtttac ccggttttaa ttatgtcaga gattgcatca      829

tccttctgct tgtttacaac tatgatcttc tatgaaatgg tggtaccaag gggcgcccaa      889

cagcttttat ccccattctt agagcatatt ctttattata atgattatcc aacatatttc      949

tttaatttta atacaaaaaa tacatcattt aatttttgtt acatatgaac attcattttt     1009

aaatgctcag cctcaagtgc aggcattttt gagtggcctg attacatatt cctcccacag     1069

caagtccgta tcctggaagt gttattttat aataaaattt aaaaagtttt aaagaattaa     1129

atcgtaggac aaattaatta aaatattgtg taaaattacc ttcaggctaa aaaaaaaaaa     1189

aa                                                                    1191


<210>  304
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Ser Val Thr Leu His Thr Asp Val Gly Asp Ile Lys Ile Glu Val 
1               5                   10                  15      


Phe Cys Glu Arg Thr Pro Lys Thr Cys Glu Met Glu Ser Arg Cys Val 
            20                  25                  30          


Pro Gln Ala Gly Val Gln Trp Arg Asp Leu Gly Ser Leu Gln Pro Pro 
        35                  40                  45              


Pro Pro Gly Phe Lys Gln Val Phe Cys Leu Ser Leu Pro Arg Thr Gly 
    50                  55                  60                  


Arg Gly Gly Asn Ser Ile Trp Gly Lys Lys Phe Glu Asp Glu Tyr Ser 
65                  70                  75                  80  


Glu Tyr Leu Lys His Asn Val Arg Gly Val Val Ser Met Ala Asn Asn 
                85                  90                  95      


Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Thr Tyr Gly Lys Gln 
            100                 105                 110         


Pro His Leu Asp Met Lys Tyr Thr Val Phe Gly Lys Val Ile Asp Gly 
        115                 120                 125             


Leu Glu Thr Leu Asp Glu Leu Glu Lys Leu Pro Val Asn Glu Lys Thr 
    130                 135                 140                 


Tyr Arg Pro Leu Asn Asp Val His Ile Lys Asp Ile Thr Ile His Ala 
145                 150                 155                 160 


Asn Pro Phe Ala Gln 
                165 


<210>  305
<211>  5581
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (155)..(2275)

<400>  305
gaccgctctt tccgggtttg cgagcggaag tggacgaatt tgaatcctgt gggccgttga       60

atgtggctgc tcgcggtcgg cgtgccccga cgtacagcgg gccgggaaaa gtggcactga      120

ggctctggaa cttctgccca gctctccttg taaa atg aat gaa agt aaa cct ggt      175
                                      Met Asn Glu Ser Lys Pro Gly         
                                      1               5                   

gac tca cag aac ctt gct tgt gtt ttc tgt cga aaa cat gat gac tgt        223
Asp Ser Gln Asn Leu Ala Cys Val Phe Cys Arg Lys His Asp Asp Cys           
        10                  15                  20                        

cct aat aaa tac gga gaa aag aaa act aag gag aaa tgg aat ctc act        271
Pro Asn Lys Tyr Gly Glu Lys Lys Thr Lys Glu Lys Trp Asn Leu Thr           
    25                  30                  35                            

gta cat tac tac tgt ttg ttg atg tca agt gga att tgg cag aga ggc        319
Val His Tyr Tyr Cys Leu Leu Met Ser Ser Gly Ile Trp Gln Arg Gly           
40                  45                  50                  55            

aaa gaa gaa gaa gga gtt tat ggt ttt cta ata gaa gat atc agg aag        367
Lys Glu Glu Glu Gly Val Tyr Gly Phe Leu Ile Glu Asp Ile Arg Lys           
                60                  65                  70                

gaa gtg aat aga gct tct aaa ctg aaa tgc tgt gtt tgc aag aaa aat        415
Glu Val Asn Arg Ala Ser Lys Leu Lys Cys Cys Val Cys Lys Lys Asn           
            75                  80                  85                    

ggt gct tca att gga tgt gtt gca ccc cga tgt aaa cga agt tat cat        463
Gly Ala Ser Ile Gly Cys Val Ala Pro Arg Cys Lys Arg Ser Tyr His           
        90                  95                  100                       

ttc cca tgt gga ctt cag aga gaa tgt att ttc cag ttt act ggc aat        511
Phe Pro Cys Gly Leu Gln Arg Glu Cys Ile Phe Gln Phe Thr Gly Asn           
    105                 110                 115                           

ttt gcg tca ttt tgt tgg gac cat cga cct gtt caa ata att aca tct        559
Phe Ala Ser Phe Cys Trp Asp His Arg Pro Val Gln Ile Ile Thr Ser           
120                 125                 130                 135           

aat aat tat aga gag tcc tta cca tgc acc att tgc ttg gaa ttt att        607
Asn Asn Tyr Arg Glu Ser Leu Pro Cys Thr Ile Cys Leu Glu Phe Ile           
                140                 145                 150               

gag cct att cca agt tat aac ata tta cga agt cct tgt tgt aag aac        655
Glu Pro Ile Pro Ser Tyr Asn Ile Leu Arg Ser Pro Cys Cys Lys Asn           
            155                 160                 165                   

gct tgg ttt cat aga gac tgt tta cag gtt caa gca ata aat gcg gga        703
Ala Trp Phe His Arg Asp Cys Leu Gln Val Gln Ala Ile Asn Ala Gly           
        170                 175                 180                       

gtg ttt ttc ttt agg tgt aca ata tgc aat aat agt gac atc ttt cag        751
Val Phe Phe Phe Arg Cys Thr Ile Cys Asn Asn Ser Asp Ile Phe Gln           
    185                 190                 195                           

aaa gag atg ttg aga atg gga att cat att cct gaa aaa gat gct tcc        799
Lys Glu Met Leu Arg Met Gly Ile His Ile Pro Glu Lys Asp Ala Ser           
200                 205                 210                 215           

tgg gaa tta gag gaa aac gct tat caa gag ctt ctg cag cac tat gag        847
Trp Glu Leu Glu Glu Asn Ala Tyr Gln Glu Leu Leu Gln His Tyr Glu           
                220                 225                 230               

cgt tgt gat gtt cga aga tgt cgt tgc aaa gaa ggg cga gac tat aat        895
Arg Cys Asp Val Arg Arg Cys Arg Cys Lys Glu Gly Arg Asp Tyr Asn           
            235                 240                 245                   

gca cct gat agc aaa tgg gaa ata aag cgc tgt cag tgt tgt ggt tcc        943
Ala Pro Asp Ser Lys Trp Glu Ile Lys Arg Cys Gln Cys Cys Gly Ser           
        250                 255                 260                       

agt ggc aca cat tta gcc tgc tcc tca tta cgg tca tgg gag caa aat        991
Ser Gly Thr His Leu Ala Cys Ser Ser Leu Arg Ser Trp Glu Gln Asn           
    265                 270                 275                           

tgg gag tgt ttg gaa tgt agg ggt att atc tac aat tca gga gag ttc       1039
Trp Glu Cys Leu Glu Cys Arg Gly Ile Ile Tyr Asn Ser Gly Glu Phe           
280                 285                 290                 295           

caa aaa gcc aaa aaa cat gta tta ccc aat tct aat aat gtg ggg att       1087
Gln Lys Ala Lys Lys His Val Leu Pro Asn Ser Asn Asn Val Gly Ile           
                300                 305                 310               

aca gat tgt ttg ttg gaa gag tca tca cct aaa tta ccc aga cag tca       1135
Thr Asp Cys Leu Leu Glu Glu Ser Ser Pro Lys Leu Pro Arg Gln Ser           
            315                 320                 325                   

cct gga tcc cag agt aaa gat cta ctg agg caa ggc agc aaa ttt aga       1183
Pro Gly Ser Gln Ser Lys Asp Leu Leu Arg Gln Gly Ser Lys Phe Arg           
        330                 335                 340                       

aga aat gta tca aca cta tta ata gag tta gga ttc caa att aaa aaa       1231
Arg Asn Val Ser Thr Leu Leu Ile Glu Leu Gly Phe Gln Ile Lys Lys           
    345                 350                 355                           

aaa act aaa aga ttg tat atc aac aaa gcc aat atc tgg aat agt gcc       1279
Lys Thr Lys Arg Leu Tyr Ile Asn Lys Ala Asn Ile Trp Asn Ser Ala           
360                 365                 370                 375           

tta gat gca ttc aga aat cga aac ttt aat cct tca tat gca att gaa       1327
Leu Asp Ala Phe Arg Asn Arg Asn Phe Asn Pro Ser Tyr Ala Ile Glu           
                380                 385                 390               

gta gca tat gtt att gaa aat gat aat ttt gga agt gag cat cct gga       1375
Val Ala Tyr Val Ile Glu Asn Asp Asn Phe Gly Ser Glu His Pro Gly           
            395                 400                 405                   

tca aag caa gaa ttt ctg agt ctc tta atg caa cat ctt gag aac tca       1423
Ser Lys Gln Glu Phe Leu Ser Leu Leu Met Gln His Leu Glu Asn Ser           
        410                 415                 420                       

tca ttg ttt gaa ggg tcc ttg tca aag aac ttg tct cta aat tct caa       1471
Ser Leu Phe Glu Gly Ser Leu Ser Lys Asn Leu Ser Leu Asn Ser Gln           
    425                 430                 435                           

gct ctg aaa gag aat ctt tac tat gaa gct ggc aaa atg ctt gcc att       1519
Ala Leu Lys Glu Asn Leu Tyr Tyr Glu Ala Gly Lys Met Leu Ala Ile           
440                 445                 450                 455           

tct tta gtt cac ggt ggt cct tca cct ggt ttc ttt tct aaa acc ttg       1567
Ser Leu Val His Gly Gly Pro Ser Pro Gly Phe Phe Ser Lys Thr Leu           
                460                 465                 470               

ttt aac tgc ctt gtt tat gga cca gaa aat acc cag cca att tta gat       1615
Phe Asn Cys Leu Val Tyr Gly Pro Glu Asn Thr Gln Pro Ile Leu Asp           
            475                 480                 485                   

gat gtt tca gac ttt gat gtg gca cag att ata atc agg ata aat act       1663
Asp Val Ser Asp Phe Asp Val Ala Gln Ile Ile Ile Arg Ile Asn Thr           
        490                 495                 500                       

gca aca act gta gct gac tta aag tca ata ata aat gaa tgc tat aac       1711
Ala Thr Thr Val Ala Asp Leu Lys Ser Ile Ile Asn Glu Cys Tyr Asn           
    505                 510                 515                           

tac ctt gag tta att gga tgt ctc aga ctt ata acg aca tta agt gat       1759
Tyr Leu Glu Leu Ile Gly Cys Leu Arg Leu Ile Thr Thr Leu Ser Asp           
520                 525                 530                 535           

aaa tat atg tta gta aaa gac ata ctt ggc tac cat gta att cag aga       1807
Lys Tyr Met Leu Val Lys Asp Ile Leu Gly Tyr His Val Ile Gln Arg           
                540                 545                 550               

gtc cac aca ccc ttt gaa agt ttt aag cag ggt ctg aaa acc ctt ggt       1855
Val His Thr Pro Phe Glu Ser Phe Lys Gln Gly Leu Lys Thr Leu Gly           
            555                 560                 565                   

gtt ttg gag aaa att cag gct tat cca gaa gca ttt tgt agc atc ctg       1903
Val Leu Glu Lys Ile Gln Ala Tyr Pro Glu Ala Phe Cys Ser Ile Leu           
        570                 575                 580                       

tgt cat aaa cct gag agt ctt tct gca aaa atc ctt agt gag ctt ttt       1951
Cys His Lys Pro Glu Ser Leu Ser Ala Lys Ile Leu Ser Glu Leu Phe           
    585                 590                 595                           

aca gta cac aca tta cct gat gtg aaa gct ttg ggg ttt tgg aac agt       1999
Thr Val His Thr Leu Pro Asp Val Lys Ala Leu Gly Phe Trp Asn Ser           
600                 605                 610                 615           

tac tta cag gct gtt gaa gat ggt aaa tct aca aca aca atg gaa gac       2047
Tyr Leu Gln Ala Val Glu Asp Gly Lys Ser Thr Thr Thr Met Glu Asp           
                620                 625                 630               

att ctt att ttt gca act ggt tgc agt tcc att cct cca gct gga ttt       2095
Ile Leu Ile Phe Ala Thr Gly Cys Ser Ser Ile Pro Pro Ala Gly Phe           
            635                 640                 645                   

aaa ccc act cct tca att gag tgt ctg cat gtg gat ttt cct gtt gga       2143
Lys Pro Thr Pro Ser Ile Glu Cys Leu His Val Asp Phe Pro Val Gly           
        650                 655                 660                       

aac aag tgt aat aac tgt tta gca att ccc atc acc aat aca tat aaa       2191
Asn Lys Cys Asn Asn Cys Leu Ala Ile Pro Ile Thr Asn Thr Tyr Lys           
    665                 670                 675                           

gag ttt caa gaa aat atg gac ttc acc ata aga aac act cta aga cta       2239
Glu Phe Gln Glu Asn Met Asp Phe Thr Ile Arg Asn Thr Leu Arg Leu           
680                 685                 690                 695           

gaa aag gaa gaa agt tct cat tac att gga cat taa aatgtttcct            2285
Glu Lys Glu Glu Ser Ser His Tyr Ile Gly His                               
                700                 705                                   

tgaacaaaga gaagcttctt taaaagctgc tattgataac tctcttttat ttcactaacc     2345

ttttcatcat cactttgaac aaactagtta gcttcttgac ctaataaaat ttatgatatg     2405

aatataaagg aatattatag ccacttaggc taaaaaaagg ttttttttgt taaagcatac     2465

tagtcaaaat tggtgataat ttctcatttt cttgatatag atacttcata aacctcaata     2525

taaatactct caaaatggtt gtatggattt tatttaggta tggtagcatg gttaataaaa     2585

gtaaaaactg ttttactcac attttttgta aattaggatt acatatagaa tgccacaatt     2645

tctctaggtt tattcaattt tcaaattatt cctcatttta ttttaaagca ttaaatagaa     2705

aagctaattg gttaaatttt gttatataaa tcagagtcat atattctggg atttgtgtta     2765

ctatgcatac ttttctagga tgtcaccaaa ttagttgttt aaaatgtttt tagattactg     2825

atttatatta agatgaccca cactgcaatt agattatgcc tagtgggaag tattatataa     2885

aaagcagaat taagctgggc acatgtgctt gtaatctcag ttataaggga ggctgaggtg     2945

ggagaatcga gatactcagc cagcctggca atgtagcaaa gactccatct caaaaaaaaa     3005

aacagaattg cacaaatttt ctggaatcta tggacattcc atgagcttaa acacttttga     3065

ggtggataac atttagttga aaatacctaa gaaagtgtgt cttctttaaa gccttggctt     3125

taatcatggg aaattgttgt tgttgttgtt gttgtttgta tcctatgttt ggtattctgt     3185

atgtctgatc cataatcatt ttagatattt gaatgatctc tgtggattgg taggtttggc     3245

catttgacca ttatttatta tcaagttggt tgtatgctaa ggtaagttga cgccatagca     3305

ttatacagtt atcttcattg ctcttgaatg atatctgtta tataagcaat gtataaataa     3365

agtaaaaagg atagaatgaa aaacccattc taatgtcacc actcagagat aagtaccgta     3425

tttctgtgta tccttctata aactctttac ttctgtttcc tttatttttt aactttaata     3485

atgctactaa aagacaatac ctaaaagtaa ctgtactaac aaagtgctaa caatgtgaaa     3545

atatatagtc ccatagtcat gtccccatat ttatactccc acagaagaaa aaattggaaa     3605

acaaagtctg atgtccttaa tctattaaca tatttaaatg atataatggt tcagttttcc     3665

atgaaagtaa atcattatgg gaagtaaaat gttttaacca tatttttctt aatacacaaa     3725

gcaggtgtca gctgttgtat tctcaccctt cttaagaaaa atcattacat tattgatatt     3785

ttttaagtaa cagaatagat ttgaaagaga taatatatct cttaatacca aaggaaaact     3845

aaaacataat tctagtgtac ttttctttgt tccctcatgt ctttttcaat ctgtacacta     3905

acatacctag caaatttgtt ttactttaac ttgaaatatt taagaacatt aaacaagaca     3965

tttctttggc tttggttgaa tttttttgtc tcaccaatag taattgaaag atcaattatc     4025

aaagagtttg aatagctaat ataaacccca aagtcaccat acagttttta ttccaaatat     4085

gttgataaaa agatatttgt ttctttatcc accttatttt tattacagct aaaaaccaat     4145

acaaaccaat aaaacctagt taaagctatt ttctggtttt tagttgcaat taatttcccc     4205

tagggtagaa attaaagctg attaagtcac acacacatac tttgttgggg tgggggtggc     4265

aggtggagag gcagtgtact tgggttagct acaattaaaa acagtatttc aattcctcat     4325

ttgacttatt ttatatatag acagggcctt agtgataaga tggtgtaaat aatttaggat     4385

attcatgttt taaagtgaag cataaatatt tattttgcaa aatgttttct agtttgaagg     4445

atgttccatt attaccattt ttagattaat ctgtatggtc aaggaatatc agagaaacct     4505

gtaggttatt tattttctgc agtgtcattt tgtcaaatgg ttggtattat aattgttctt     4565

ttcttattaa ttttataacc agtgcataat tcttacatta gattttaaaa aagaattatg     4625

ctataaatct ttataaatgt gtacatatat ttcttaaata ttgcaattgc ctaaatgttg     4685

tatattttaa ggctgttttc tcttgctctt aatgttgagg aaaactataa attgatctat     4745

aatgcatcta ctgttaatgg ttttggttag tttgatattc attgttttta aacactttcc     4805

aatatggaaa ctttaacacc ttttatacaa ttctctacta ttcaagatat tctttaaaat     4865

atctcaccag aaacttacaa ttttatactt tgtaattttt agtttctgta atttgaggaa     4925

gtgacttttt ttgtttgggt taagtaaaaa gcctttgatt gattaccagc atgagaattc     4985

accttggttt ctattttatg catttgtaaa tttttcccct aattatatgg aagctattgg     5045

aacttttgta ttcagtgcta aatactaagt caaggggagt atattaggta agttttttca     5105

gtgactgtgc ctttagcatt cagtcattat aagaaaatga tcagaacaaa atcattacat     5165

tataaacatg taattctttt atatagtgat tatcatgtac tgcattgtta ctttaaaata     5225

agctattaaa ctagttttta tggttcaagt aatgcaatac aaagtttcat gcttcaagta     5285

atgcaataca aaacataacc catttaatga tgaattactt gaatgtatat tatctgtggt     5345

ttaggaaaat ttggattgtc ttgaagagac tcagttttca agttctgatt ttgaccatta     5405

tctcttctaa ttcataaaca tatcccagta cctacactat gccaggtatt atgctaggtg     5465

atcgtttata tgtcagccta tttccccccc ttttaaagac tgccagatta accaaaaagc     5525

gtgacattta taacaatgtt ttataaataa ataaatgtgt ttatgccact aaaggt         5581


<210>  306
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe 
1               5                   10                  15      


Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr 
            20                  25                  30          


Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser 
        35                  40                  45              


Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe 
    50                  55                  60                  


Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Lys 
65                  70                  75                  80  


Cys Cys Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val Ala Pro 
                85                  90                  95      


Arg Cys Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg Glu Cys 
            100                 105                 110         


Ile Phe Gln Phe Thr Gly Asn Phe Ala Ser Phe Cys Trp Asp His Arg 
        115                 120                 125             


Pro Val Gln Ile Ile Thr Ser Asn Asn Tyr Arg Glu Ser Leu Pro Cys 
    130                 135                 140                 


Thr Ile Cys Leu Glu Phe Ile Glu Pro Ile Pro Ser Tyr Asn Ile Leu 
145                 150                 155                 160 


Arg Ser Pro Cys Cys Lys Asn Ala Trp Phe His Arg Asp Cys Leu Gln 
                165                 170                 175     


Val Gln Ala Ile Asn Ala Gly Val Phe Phe Phe Arg Cys Thr Ile Cys 
            180                 185                 190         


Asn Asn Ser Asp Ile Phe Gln Lys Glu Met Leu Arg Met Gly Ile His 
        195                 200                 205             


Ile Pro Glu Lys Asp Ala Ser Trp Glu Leu Glu Glu Asn Ala Tyr Gln 
    210                 215                 220                 


Glu Leu Leu Gln His Tyr Glu Arg Cys Asp Val Arg Arg Cys Arg Cys 
225                 230                 235                 240 


Lys Glu Gly Arg Asp Tyr Asn Ala Pro Asp Ser Lys Trp Glu Ile Lys 
                245                 250                 255     


Arg Cys Gln Cys Cys Gly Ser Ser Gly Thr His Leu Ala Cys Ser Ser 
            260                 265                 270         


Leu Arg Ser Trp Glu Gln Asn Trp Glu Cys Leu Glu Cys Arg Gly Ile 
        275                 280                 285             


Ile Tyr Asn Ser Gly Glu Phe Gln Lys Ala Lys Lys His Val Leu Pro 
    290                 295                 300                 


Asn Ser Asn Asn Val Gly Ile Thr Asp Cys Leu Leu Glu Glu Ser Ser 
305                 310                 315                 320 


Pro Lys Leu Pro Arg Gln Ser Pro Gly Ser Gln Ser Lys Asp Leu Leu 
                325                 330                 335     


Arg Gln Gly Ser Lys Phe Arg Arg Asn Val Ser Thr Leu Leu Ile Glu 
            340                 345                 350         


Leu Gly Phe Gln Ile Lys Lys Lys Thr Lys Arg Leu Tyr Ile Asn Lys 
        355                 360                 365             


Ala Asn Ile Trp Asn Ser Ala Leu Asp Ala Phe Arg Asn Arg Asn Phe 
    370                 375                 380                 


Asn Pro Ser Tyr Ala Ile Glu Val Ala Tyr Val Ile Glu Asn Asp Asn 
385                 390                 395                 400 


Phe Gly Ser Glu His Pro Gly Ser Lys Gln Glu Phe Leu Ser Leu Leu 
                405                 410                 415     


Met Gln His Leu Glu Asn Ser Ser Leu Phe Glu Gly Ser Leu Ser Lys 
            420                 425                 430         


Asn Leu Ser Leu Asn Ser Gln Ala Leu Lys Glu Asn Leu Tyr Tyr Glu 
        435                 440                 445             


Ala Gly Lys Met Leu Ala Ile Ser Leu Val His Gly Gly Pro Ser Pro 
    450                 455                 460                 


Gly Phe Phe Ser Lys Thr Leu Phe Asn Cys Leu Val Tyr Gly Pro Glu 
465                 470                 475                 480 


Asn Thr Gln Pro Ile Leu Asp Asp Val Ser Asp Phe Asp Val Ala Gln 
                485                 490                 495     


Ile Ile Ile Arg Ile Asn Thr Ala Thr Thr Val Ala Asp Leu Lys Ser 
            500                 505                 510         


Ile Ile Asn Glu Cys Tyr Asn Tyr Leu Glu Leu Ile Gly Cys Leu Arg 
        515                 520                 525             


Leu Ile Thr Thr Leu Ser Asp Lys Tyr Met Leu Val Lys Asp Ile Leu 
    530                 535                 540                 


Gly Tyr His Val Ile Gln Arg Val His Thr Pro Phe Glu Ser Phe Lys 
545                 550                 555                 560 


Gln Gly Leu Lys Thr Leu Gly Val Leu Glu Lys Ile Gln Ala Tyr Pro 
                565                 570                 575     


Glu Ala Phe Cys Ser Ile Leu Cys His Lys Pro Glu Ser Leu Ser Ala 
            580                 585                 590         


Lys Ile Leu Ser Glu Leu Phe Thr Val His Thr Leu Pro Asp Val Lys 
        595                 600                 605             


Ala Leu Gly Phe Trp Asn Ser Tyr Leu Gln Ala Val Glu Asp Gly Lys 
    610                 615                 620                 


Ser Thr Thr Thr Met Glu Asp Ile Leu Ile Phe Ala Thr Gly Cys Ser 
625                 630                 635                 640 


Ser Ile Pro Pro Ala Gly Phe Lys Pro Thr Pro Ser Ile Glu Cys Leu 
                645                 650                 655     


His Val Asp Phe Pro Val Gly Asn Lys Cys Asn Asn Cys Leu Ala Ile 
            660                 665                 670         


Pro Ile Thr Asn Thr Tyr Lys Glu Phe Gln Glu Asn Met Asp Phe Thr 
        675                 680                 685             


Ile Arg Asn Thr Leu Arg Leu Glu Lys Glu Glu Ser Ser His Tyr Ile 
    690                 695                 700                 


Gly His 
705     


<210>  307
<211>  890
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (181)..(609)

<400>  307
atcttcaccc aggctggccc ctttggtgaa actacaactc ccaggggtct gtgcgcgaga       60

aggcaggcgg gtttttctac cggaagtccg ctctagctct gggccctaca actgcaccct      120

gagccggagc tgcccagtcg ccgcgggacc ggggccgctg gggtctggac gggggtcgcc      180

atg atc cgc ttt atc ctc atc cag aac cgg gca ggc aag acg cgc ctg        228
Met Ile Arg Phe Ile Leu Ile Gln Asn Arg Ala Gly Lys Thr Arg Leu           
1               5                   10                  15                

gcc aag tgg tac atg cag ttt gat gat gat gag aaa cag aag ctg atc        276
Ala Lys Trp Tyr Met Gln Phe Asp Asp Asp Glu Lys Gln Lys Leu Ile           
            20                  25                  30                    

gag gag gtg cat gcc gtg gtc acc gtc cga gac gcc aaa cac acc aac        324
Glu Glu Val His Ala Val Val Thr Val Arg Asp Ala Lys His Thr Asn           
        35                  40                  45                        

ttt gtg gag ttc cgg aac ttt aag atc att tac cgc cgc tat gct ggc        372
Phe Val Glu Phe Arg Asn Phe Lys Ile Ile Tyr Arg Arg Tyr Ala Gly           
    50                  55                  60                            

ctc tac ttc tgc atc tgt gtg gat gtc aat gac aac aac ctg gct tac        420
Leu Tyr Phe Cys Ile Cys Val Asp Val Asn Asp Asn Asn Leu Ala Tyr           
65                  70                  75                  80            

ctg gag gcc att cac aac ttc gtg gag gtc tta aac gaa tat ttc cac        468
Leu Glu Ala Ile His Asn Phe Val Glu Val Leu Asn Glu Tyr Phe His           
                85                  90                  95                

aat gtc tgt gaa ctg gac ctg gtg ttc aac ttc tac aag gtt tac acg        516
Asn Val Cys Glu Leu Asp Leu Val Phe Asn Phe Tyr Lys Val Tyr Thr           
            100                 105                 110                   

gtc gtg gac gag atg ttc ctg gct ggc gaa atc cga gag acc agc cag        564
Val Val Asp Glu Met Phe Leu Ala Gly Glu Ile Arg Glu Thr Ser Gln           
        115                 120                 125                       

acg aag gtg ctg aaa cag ctg ctg atg cta cag tcc ctg gag tga            609
Thr Lys Val Leu Lys Gln Leu Leu Met Leu Gln Ser Leu Glu                   
    130                 135                 140                           

gggcaggcga gccccacccc ggccccggcc cctcctggac tcgcctgctc gcttcccctt      669

cccaggcccg tggccaaccc agcagtcctt ccctcagctg cctaggagga agggacccag      729

ctgggtctgg gccacaaggg aggagactgc accccactgc ctctgggccc tggctgtggg      789

cagaggccac cgtgtgtgtc ccgagtaacc gtgccgttgt cgtgtgatgc cataagcgtc      849

tgtgcgtgga gtccccaata aacctgtggt cctgcctggc c                          890


<210>  308
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Ile Arg Phe Ile Leu Ile Gln Asn Arg Ala Gly Lys Thr Arg Leu 
1               5                   10                  15      


Ala Lys Trp Tyr Met Gln Phe Asp Asp Asp Glu Lys Gln Lys Leu Ile 
            20                  25                  30          


Glu Glu Val His Ala Val Val Thr Val Arg Asp Ala Lys His Thr Asn 
        35                  40                  45              


Phe Val Glu Phe Arg Asn Phe Lys Ile Ile Tyr Arg Arg Tyr Ala Gly 
    50                  55                  60                  


Leu Tyr Phe Cys Ile Cys Val Asp Val Asn Asp Asn Asn Leu Ala Tyr 
65                  70                  75                  80  


Leu Glu Ala Ile His Asn Phe Val Glu Val Leu Asn Glu Tyr Phe His 
                85                  90                  95      


Asn Val Cys Glu Leu Asp Leu Val Phe Asn Phe Tyr Lys Val Tyr Thr 
            100                 105                 110         


Val Val Asp Glu Met Phe Leu Ala Gly Glu Ile Arg Glu Thr Ser Gln 
        115                 120                 125             


Thr Lys Val Leu Lys Gln Leu Leu Met Leu Gln Ser Leu Glu 
    130                 135                 140         


<210>  309
<211>  2612
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (323)..(1282)

<400>  309
tgcagagggc gcagctccac cgtggtaact tgcaatgtgg ccgcccctgc gctggcttct       60

ttctcctcgg ccctcggtga acccagcttt tcctttaaag catagacaaa tccttgctta      120

gggtcagcca gaccgtgggc ttgctttggg ctcccgcgtg gacgctgaag gctcttcatg      180

atttctcaga aaccttggtg ggccacccaa aaagtgtgtt ggaaatccac ggtgatcctt      240

aatatggtga tgggattgtc cgaaaaggat ttcagatgca tgccaggttt ccactgattg      300

ccagaactcg agatcactac ac atg gat ccc caa aat caa cat ggc agt ggc       352
                         Met Asp Pro Gln Asn Gln His Gly Ser Gly          
                         1               5                   10           

agt tcg tta gtt gtg atc cag cag cct tct ttg gat agc cgt cag aga        400
Ser Ser Leu Val Val Ile Gln Gln Pro Ser Leu Asp Ser Arg Gln Arg           
                15                  20                  25                

tta gac tat gag aga gag att cag cct act gct att ttg tcc tta gac        448
Leu Asp Tyr Glu Arg Glu Ile Gln Pro Thr Ala Ile Leu Ser Leu Asp           
            30                  35                  40                    

cag atc aag gcc ata aga ggc agc aat gaa tac aca gaa ggg cct tcg        496
Gln Ile Lys Ala Ile Arg Gly Ser Asn Glu Tyr Thr Glu Gly Pro Ser           
        45                  50                  55                        

gtg gtg aaa aga cct gct cct cgg aca gca cca aga caa gaa aag cat        544
Val Val Lys Arg Pro Ala Pro Arg Thr Ala Pro Arg Gln Glu Lys His           
    60                  65                  70                            

gaa agg act cat gaa atc ata cca att aat gtg aat aat aac tac gag        592
Glu Arg Thr His Glu Ile Ile Pro Ile Asn Val Asn Asn Asn Tyr Glu           
75                  80                  85                  90            

cac aga cac aca agc cac ctg gga cat gca gta ctc cca agt aat gcc        640
His Arg His Thr Ser His Leu Gly His Ala Val Leu Pro Ser Asn Ala           
                95                  100                 105               

agg ggc ccc att ttg agc aga tca acc agc act gga agt gca gcc agc        688
Arg Gly Pro Ile Leu Ser Arg Ser Thr Ser Thr Gly Ser Ala Ala Ser           
            110                 115                 120                   

tct ggg agc aac agc agt gcc tct tct gaa cag gga ctg tta gga agg        736
Ser Gly Ser Asn Ser Ser Ala Ser Ser Glu Gln Gly Leu Leu Gly Arg           
        125                 130                 135                       

tca cca cca acc aga cca gtc cct ggt cat agg tct gaa agg gca atc        784
Ser Pro Pro Thr Arg Pro Val Pro Gly His Arg Ser Glu Arg Ala Ile           
    140                 145                 150                           

cgg acc cag ccc aag caa ctg att gtg gat gac ttg aag ggt tcc ttg        832
Arg Thr Gln Pro Lys Gln Leu Ile Val Asp Asp Leu Lys Gly Ser Leu           
155                 160                 165                 170           

aaa gag gac ctg aca cag cac aag ttc att tgt gaa cag tgt ggg aag        880
Lys Glu Asp Leu Thr Gln His Lys Phe Ile Cys Glu Gln Cys Gly Lys           
                175                 180                 185               

tgc aag tgt gga gaa tgc act gct ccc agg acc cta cca tcc tgt ttg        928
Cys Lys Cys Gly Glu Cys Thr Ala Pro Arg Thr Leu Pro Ser Cys Leu           
            190                 195                 200                   

gcc tgt aac cgg cag tgc ctt tgc tct gct gag agc atg gtg gaa tat        976
Ala Cys Asn Arg Gln Cys Leu Cys Ser Ala Glu Ser Met Val Glu Tyr           
        205                 210                 215                       

gga acc tgc atg tgc tta gtc aag ggc atc ttc tac cac tgc tcc aat       1024
Gly Thr Cys Met Cys Leu Val Lys Gly Ile Phe Tyr His Cys Ser Asn           
    220                 225                 230                           

gac gac gaa ggg gat tcc tat tca gat aat cct tgc tcc tgt tca caa       1072
Asp Asp Glu Gly Asp Ser Tyr Ser Asp Asn Pro Cys Ser Cys Ser Gln           
235                 240                 245                 250           

tca cac tgc tgc tct aga tac ctg tgt atg gga gcc atg tct tta ttt       1120
Ser His Cys Cys Ser Arg Tyr Leu Cys Met Gly Ala Met Ser Leu Phe           
                255                 260                 265               

tta cct tgc tta ctc tgt tat cct cct gct aaa gga tgc ctg aag ctg       1168
Leu Pro Cys Leu Leu Cys Tyr Pro Pro Ala Lys Gly Cys Leu Lys Leu           
            270                 275                 280                   

tgc agg agg tgt tat gac tgg atc cat cgc cca ggg tgc aga tgt aag       1216
Cys Arg Arg Cys Tyr Asp Trp Ile His Arg Pro Gly Cys Arg Cys Lys           
        285                 290                 295                       

aac tcc aac act gtc tat tgt aag ctg gag agc tgc ccc tcc cgg ggt       1264
Asn Ser Asn Thr Val Tyr Cys Lys Leu Glu Ser Cys Pro Ser Arg Gly           
    300                 305                 310                           

cag ggt aaa cca tca tga tttttggagg tgggttgtac ctcctgaact              1312
Gln Gly Lys Pro Ser                                                       
315                                                                       

tttagctttc aagttgtggc tgttttttgt ttttgttttt gtttttgttt tctttagaat     1372

ttttccctgt ttcccacctt ctcttcccct gttgccaagg tctaactcat ggatttttct     1432

ctttcctcat ggatgatctt cagcaagagt ggactgggaa gctgcacctg gctcccactt     1492

tcaacaagag cctctgccat ccacttgagg gtattgagag ccagtgggct tttgtgtagc     1552

ctttttgttc tgcaagcaac tttctaaagt tgtgtacatg aacatacacc cacatccaga     1612

ctacagtgat ttagagttgt tttgattggg taccgtggga gcagggaaat tggtttttta     1672

aaaagcaact gtttaattgc ttaaataagc tatgtattaa atctgtctcc agttagggct     1732

atcttcctag cataggcccc ttaagtagca tgggggatat attttttgct ataacgtaaa     1792

aattttcctt taaccactgc cctctccttc tttctccttc aaggttcttt ccccctcagt     1852

tttgttgttg tcttactctg gagatgccaa gtgtattttt tctttctatg taattttaga     1912

ttcgccttac aatgtaaatc ttcacattgg agataatatt ggttggacct tgcccatctt     1972

cactctagcc ttcgtatttg tgaaggactc agccaccttc cttcttcacc ccatgcttct     2032

caccaaattt ttgttgtcat tgagggcact tggataactc aagttgatat ttatagctga     2092

tcaatctata tgtgtcacag aactatgctg cctaaagtga tcttggctcc ttaatggtcc     2152

ttttggcccc ttggatagtt aacagctgag taattctaat ctcttctgtg ttttccttgc     2212

cttaaccaca aattgtggtg ctttttgtat attttatgta taaatcacaa agttgaattc     2272

tgactatttt taagacaaaa gtctgttaaa cttttttatt gtaaagaata tttattatgc     2332

gaatctctat tattttatgg tatttattgc aaaagactgt tgaaatgtac tcatgtttga     2392

atataacaaa atatcaatac ttaacggaaa ataaggtgac acgaagaaag tacatatgtt     2452

aactataatg cagaaaatat attaattaat gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2512

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2572

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           2612


<210>  310
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Asp Pro Gln Asn Gln His Gly Ser Gly Ser Ser Leu Val Val Ile 
1               5                   10                  15      


Gln Gln Pro Ser Leu Asp Ser Arg Gln Arg Leu Asp Tyr Glu Arg Glu 
            20                  25                  30          


Ile Gln Pro Thr Ala Ile Leu Ser Leu Asp Gln Ile Lys Ala Ile Arg 
        35                  40                  45              


Gly Ser Asn Glu Tyr Thr Glu Gly Pro Ser Val Val Lys Arg Pro Ala 
    50                  55                  60                  


Pro Arg Thr Ala Pro Arg Gln Glu Lys His Glu Arg Thr His Glu Ile 
65                  70                  75                  80  


Ile Pro Ile Asn Val Asn Asn Asn Tyr Glu His Arg His Thr Ser His 
                85                  90                  95      


Leu Gly His Ala Val Leu Pro Ser Asn Ala Arg Gly Pro Ile Leu Ser 
            100                 105                 110         


Arg Ser Thr Ser Thr Gly Ser Ala Ala Ser Ser Gly Ser Asn Ser Ser 
        115                 120                 125             


Ala Ser Ser Glu Gln Gly Leu Leu Gly Arg Ser Pro Pro Thr Arg Pro 
    130                 135                 140                 


Val Pro Gly His Arg Ser Glu Arg Ala Ile Arg Thr Gln Pro Lys Gln 
145                 150                 155                 160 


Leu Ile Val Asp Asp Leu Lys Gly Ser Leu Lys Glu Asp Leu Thr Gln 
                165                 170                 175     


His Lys Phe Ile Cys Glu Gln Cys Gly Lys Cys Lys Cys Gly Glu Cys 
            180                 185                 190         


Thr Ala Pro Arg Thr Leu Pro Ser Cys Leu Ala Cys Asn Arg Gln Cys 
        195                 200                 205             


Leu Cys Ser Ala Glu Ser Met Val Glu Tyr Gly Thr Cys Met Cys Leu 
    210                 215                 220                 


Val Lys Gly Ile Phe Tyr His Cys Ser Asn Asp Asp Glu Gly Asp Ser 
225                 230                 235                 240 


Tyr Ser Asp Asn Pro Cys Ser Cys Ser Gln Ser His Cys Cys Ser Arg 
                245                 250                 255     


Tyr Leu Cys Met Gly Ala Met Ser Leu Phe Leu Pro Cys Leu Leu Cys 
            260                 265                 270         


Tyr Pro Pro Ala Lys Gly Cys Leu Lys Leu Cys Arg Arg Cys Tyr Asp 
        275                 280                 285             


Trp Ile His Arg Pro Gly Cys Arg Cys Lys Asn Ser Asn Thr Val Tyr 
    290                 295                 300                 


Cys Lys Leu Glu Ser Cys Pro Ser Arg Gly Gln Gly Lys Pro Ser 
305                 310                 315                 


<210>  311
<211>  5850
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (30)..(2039)

<400>  311
gagggctccg gagcggcgac tggcgagcc atg gcg ctg ggg ctg cag cgc gca         53
                                Met Ala Leu Gly Leu Gln Arg Ala           
                                1               5                         

agg tcg acc acg gag ctg cgc aag gaa aag tcc cgg gat gcg gcc cgc        101
Arg Ser Thr Thr Glu Leu Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg           
    10                  15                  20                            

agc cgg cgc agc cag gag acc gag gtg ctg tac cag ctg gct cac acg        149
Ser Arg Arg Ser Gln Glu Thr Glu Val Leu Tyr Gln Leu Ala His Thr           
25                  30                  35                  40            

ctg ccc ttc gcc cgc ggc gtc agc gcc cac ctg gac aag gcc tct atc        197
Leu Pro Phe Ala Arg Gly Val Ser Ala His Leu Asp Lys Ala Ser Ile           
                45                  50                  55                

atg cgc ctc acc atc agc tac ctg cgc atg cac cgc ctc tgc gcc gca        245
Met Arg Leu Thr Ile Ser Tyr Leu Arg Met His Arg Leu Cys Ala Ala           
            60                  65                  70                    

ggg gag tgg aac cag gtg gga gca ggg gga gaa cca ctg gat gcc tgc        293
Gly Glu Trp Asn Gln Val Gly Ala Gly Gly Glu Pro Leu Asp Ala Cys           
        75                  80                  85                        

tac ctg aag gcc ctg gag ggc ttc gtc atg gtg ctc acc gcc gag gga        341
Tyr Leu Lys Ala Leu Glu Gly Phe Val Met Val Leu Thr Ala Glu Gly           
    90                  95                  100                           

gac atg gct tac ctg tcg gag aat gtc agc aaa cac ctg ggc ctc agt        389
Asp Met Ala Tyr Leu Ser Glu Asn Val Ser Lys His Leu Gly Leu Ser           
105                 110                 115                 120           

cag ctg gag ctc att gga cac agc atc ttt gat ttc atc cac ccc tgt        437
Gln Leu Glu Leu Ile Gly His Ser Ile Phe Asp Phe Ile His Pro Cys           
                125                 130                 135               

gac caa gag gag ctt cag gac gcc ctg acc ccc cag cag acc ctg tcc        485
Asp Gln Glu Glu Leu Gln Asp Ala Leu Thr Pro Gln Gln Thr Leu Ser           
            140                 145                 150                   

agg agg aag gtg gag gcc ccc acg gag cgg tgc ttc tcc ttg cgc atg        533
Arg Arg Lys Val Glu Ala Pro Thr Glu Arg Cys Phe Ser Leu Arg Met           
        155                 160                 165                       

aag agt aca ctc acc agc cgc ggg cgc acc ctc aac ctc aag gcg gcc        581
Lys Ser Thr Leu Thr Ser Arg Gly Arg Thr Leu Asn Leu Lys Ala Ala           
    170                 175                 180                           

acc tgg aag gtg ctg aac tgc tct gga cat atg agg gcc tac aag cca        629
Thr Trp Lys Val Leu Asn Cys Ser Gly His Met Arg Ala Tyr Lys Pro           
185                 190                 195                 200           

cct gcg cag act tct cca gct ggg agc cct gac tca gag ccc ccg ctg        677
Pro Ala Gln Thr Ser Pro Ala Gly Ser Pro Asp Ser Glu Pro Pro Leu           
                205                 210                 215               

cag tgc ctg gtg ctc atc tgc gaa gcc atc ccc cac cca ggc agc ctg        725
Gln Cys Leu Val Leu Ile Cys Glu Ala Ile Pro His Pro Gly Ser Leu           
            220                 225                 230                   

gag ccc cca ctg ggc cga ggg gcc ttc ctc agc cgc cac agc ctg gac        773
Glu Pro Pro Leu Gly Arg Gly Ala Phe Leu Ser Arg His Ser Leu Asp           
        235                 240                 245                       

atg aag ttc acc tac tgt gac gac agg att gca gaa gtg gct ggc tat        821
Met Lys Phe Thr Tyr Cys Asp Asp Arg Ile Ala Glu Val Ala Gly Tyr           
    250                 255                 260                           

agt ccc gat gac ctg atc ggc tgt tcc gcc tac gag tac atc cac gcg        869
Ser Pro Asp Asp Leu Ile Gly Cys Ser Ala Tyr Glu Tyr Ile His Ala           
265                 270                 275                 280           

ctg gac tcc gat gcg gtc agc aag agc atc cac acc ttg ctg agc aag        917
Leu Asp Ser Asp Ala Val Ser Lys Ser Ile His Thr Leu Leu Ser Lys           
                285                 290                 295               

ggc cag gca gta aca ggg cag tat cgc ttc ctg gcc cgg agt ggt ggc        965
Gly Gln Ala Val Thr Gly Gln Tyr Arg Phe Leu Ala Arg Ser Gly Gly           
            300                 305                 310                   

tac ctg tgg acc cag acc cag gcc aca gtg gtg tca ggg gga cgg ggc       1013
Tyr Leu Trp Thr Gln Thr Gln Ala Thr Val Val Ser Gly Gly Arg Gly           
        315                 320                 325                       

ccc cag tcg gag agt atc gtc tgt gtc cat ttt tta atc agc cag gtg       1061
Pro Gln Ser Glu Ser Ile Val Cys Val His Phe Leu Ile Ser Gln Val           
    330                 335                 340                           

gaa gag acc gga gtg gtg ctg tcc ctg gag caa acg gag caa cac tct       1109
Glu Glu Thr Gly Val Val Leu Ser Leu Glu Gln Thr Glu Gln His Ser           
345                 350                 355                 360           

cgc aga ccc att cag cgg ggc gcc ccc tct cag aag gac acc cct aac       1157
Arg Arg Pro Ile Gln Arg Gly Ala Pro Ser Gln Lys Asp Thr Pro Asn           
                365                 370                 375               

cct ggg gac agc ctt gac acc cct ggc ccc cgg atc ctt gcc ttc ctg       1205
Pro Gly Asp Ser Leu Asp Thr Pro Gly Pro Arg Ile Leu Ala Phe Leu           
            380                 385                 390                   

cac ccg cct tcc ctg agc gag gct gcc ctg gcc gct gac ccc cgc cgt       1253
His Pro Pro Ser Leu Ser Glu Ala Ala Leu Ala Ala Asp Pro Arg Arg           
        395                 400                 405                       

ttc tgc agc cct gac ctc cgt cgc ctc ctg gga ccc atc ctg gat ggg       1301
Phe Cys Ser Pro Asp Leu Arg Arg Leu Leu Gly Pro Ile Leu Asp Gly           
    410                 415                 420                           

gct tca gta gca gcc act ccc agc acc ccg ctg gcc aca cgg cac ccc       1349
Ala Ser Val Ala Ala Thr Pro Ser Thr Pro Leu Ala Thr Arg His Pro           
425                 430                 435                 440           

caa agt cct ctt tcg gct gat ctc cca gat gaa cta cct gtg ggc acc       1397
Gln Ser Pro Leu Ser Ala Asp Leu Pro Asp Glu Leu Pro Val Gly Thr           
                445                 450                 455               

gag aat gtg cac aga ctc ttc acc tcc ggg aaa gac act gag gca gtg       1445
Glu Asn Val His Arg Leu Phe Thr Ser Gly Lys Asp Thr Glu Ala Val           
            460                 465                 470                   

gag aca gat tta gat ata gct cag gat gct gat gct ctg gat ttg gag       1493
Glu Thr Asp Leu Asp Ile Ala Gln Asp Ala Asp Ala Leu Asp Leu Glu           
        475                 480                 485                       

atg ctg gcc ccc tac atc tcc atg gat gat gac ttc cag ctc aac gcc       1541
Met Leu Ala Pro Tyr Ile Ser Met Asp Asp Asp Phe Gln Leu Asn Ala           
    490                 495                 500                           

agc gag cag cta ccc agg gcc tac cac aga cct ctg ggg gct gtc ccc       1589
Ser Glu Gln Leu Pro Arg Ala Tyr His Arg Pro Leu Gly Ala Val Pro           
505                 510                 515                 520           

cgg ccc cgt gct cgg agc ttc cat ggc ctg tca cct cca gcc ctt gag       1637
Arg Pro Arg Ala Arg Ser Phe His Gly Leu Ser Pro Pro Ala Leu Glu           
                525                 530                 535               

ccc tcc ctg cta ccc cgc tgg ggg agt gac ccc cgg ctg agc tgc tcc       1685
Pro Ser Leu Leu Pro Arg Trp Gly Ser Asp Pro Arg Leu Ser Cys Ser           
            540                 545                 550                   

agc cct tcc aga ggg gac ccc tca gca tcc tct ccc atg gct ggg gct       1733
Ser Pro Ser Arg Gly Asp Pro Ser Ala Ser Ser Pro Met Ala Gly Ala           
        555                 560                 565                       

cgg aag agg acc ctg gcc cag agc tca gag gac gag gac gag gga gtg       1781
Arg Lys Arg Thr Leu Ala Gln Ser Ser Glu Asp Glu Asp Glu Gly Val           
    570                 575                 580                           

gag ctg ctg gga gtg aga cct ccc aaa agg tcc ccc agc cca gaa cac       1829
Glu Leu Leu Gly Val Arg Pro Pro Lys Arg Ser Pro Ser Pro Glu His           
585                 590                 595                 600           

gaa aac ttt ctg ctc ttt cct ctc agc ctg agt ttc ctt ctg aca gga       1877
Glu Asn Phe Leu Leu Phe Pro Leu Ser Leu Ser Phe Leu Leu Thr Gly           
                605                 610                 615               

gga cca gcc cca ggg agc ctg cag gac ccc agc acc cca ctc ctg aac       1925
Gly Pro Ala Pro Gly Ser Leu Gln Asp Pro Ser Thr Pro Leu Leu Asn           
            620                 625                 630                   

ctg aat gag ccc ctg ggc ctg ggc ccc tca ctg ctc tct ccg tac tca       1973
Leu Asn Glu Pro Leu Gly Leu Gly Pro Ser Leu Leu Ser Pro Tyr Ser           
        635                 640                 645                       

gac gag gac act acc cag ccc ggg ggc ccc ttc cag cca agg gca ggc       2021
Asp Glu Asp Thr Thr Gln Pro Gly Gly Pro Phe Gln Pro Arg Ala Gly           
    650                 655                 660                           

tca gcc cag gct gac tga gccggctcct ctccccatct gccttctcct              2069
Ser Ala Gln Ala Asp                                                       
665                                                                       

cccccagaaa ggacctcaac cacactccac gccggcagcc aacgcacagg atgggggcgc     2129

caggagaggg gcccctctct cctctatgta ccccctgccc acctcgggcc tacctcagcc     2189

ctcacccctc tgcctgctcc caatctgggg gctctctggg gtggtctcag ctcagtgacc     2249

tctgggaggt ggtccctggc cccctcctcc ttctctcagg atttctcttg gggttctcaa     2309

tacttggtta cctcattatc cctttctctg cctctcttgg ctttattttg gggaatcagg     2369

ggtgaggagg gttggggggg tcatatctgt gtttccaggt tctggggaga acaatgatcc     2429

acgggtcaac gtgatcacat ttccttctat ccttcttgta ttattatttt tatttttgtc     2489

aatttcatga tatggttttt aatcatgatg aattgcctgg ggtctgtaag aatgtgggac     2549

tctgatcttc cccctcttca ggtgtcagtg cggagaggct ctgggccaga cctcaccccc     2609

agtgacttcc gattgaggcc aaagacccca agctgcccgc cagctctgac tgccccttgc     2669

gctctgggct tcctgccgcc cccagctttg cctggacact gacttcattc atggtcctcc     2729

tacttcaggg gcagcctccc agttcctctg cttccaaact atgcaacctc caacctgctc     2789

cagttccaga ctgtataacc tctgacctgc actggttcta gaccacacaa cctccaatgt     2849

ggtctgcttt agatcacctt cttcttcttc cttcttcctc ttcctcttcc tcctgctcct     2909

cttcctcttc ttcttctttt ttttttttga cagagtcttg ctctgtcacc caggctggag     2969

tgcagtggcg cgatttcagc ttactgcagc ctccgcgccc tgggttcaag tgattctcct     3029

gcctcaactt cccaaatagc cgggactacg ggcatgtgcc acattgcccg gctaattttt     3089

gtatttttag tagagatggg gtttcaccac gttgtccagt ctggtctcga actcctgacc     3149

tcaagtgctc cacctgcctc agccttccaa agtgctggga ttacaggcgt gagccactgc     3209

acccggctag aactcacttt ctccaaatcc ctctgcttcg aatttcaccg tcttcagctc     3269

tttctagttc tgggcctcac cagcctctca ttctgcctgt tttcaaacct tacgatcccc     3329

aaaaattgtc tggttctggg cctctaactc cctctggctc tatagtctat gactaccaga     3389

ttcttttggt tctagaattc actaacttcc tctggttcta gacctcttcc tataaattaa     3449

tccctcttgt tttagatctc acaccctcca acgccctccg gttccagatc ttatattcag     3509

tgatttcctc tggttctgga ccccacaact ccaagcttcc tattggttcc agttctcctg     3569

atcggtaata catttggttc caaatccaga cctcttaatc tctctctttt tttttttttt     3629

tttttgagac agagtcccac tctgtcaccc aggctggagt acagtggctc aatctcggct     3689

cactgcagcc tccacctcct gggttcaagc aattcttggg cctcagcctc ccaaatagct     3749

gggattacag gcatgtgcca ccacgcccag ctaagtttta tatttttagt agagacagtg     3809

tttcaccatg ttggccaggc tggtcttgaa ctcccgacct caactgatcc acccgcctca     3869

gcctcccaaa gtgctgaaat tacaggagtg agcctggcca gacttcttaa tttctaaatc     3929

acttttgttt tagaccttat gaggctcagc ttattcttct gcagttctct ataaccaaga     3989

ctcattttct ctcatcaaaa acaagtacag agagtttgat gtgtttatct cttttttctt     4049

cctcttcttt tttttttttt tcttttttga gatggagtct ctctctgttg cccaggctgg     4109

agtataatgg tgccatctag gctcactgca acctccgcct cctgattcaa gtgattctcc     4169

tgcctcagcc tcctaaattg gtgggattac aggagcccac caccacatcc ggctaccttt     4229

gtgtattttt tagtagagac ggggttttgc caagttggag gggctggtct tgaactcttg     4289

acctcagatg atccacccgc ctcagcctcc caaagtgctg ggattacagg cataagccac     4349

cgtgcccgac cctgtcctta tcttataata accagttctt ctagaaccag acgatgctct     4409

agttctccta gattctgaac ctcatgacct gtaccactca ctagttccag actacacaac     4469

ttctagaagg tgccacctcc agggtcctga ttcaagatct ggtgatctgc tgtttctctg     4529

gttctagaac tgacttacaa gtgccttctg attctagacc tcattccgta agttcccttg     4589

gctctagact tcatcatttc cagctcctcc tcactcaaga tctgactcca aattaccctg     4649

ggtctagaat tcagccttca aatatcttct gattttagac tttgccttat acatttctct     4709

ggttttagat cttaccaccc tcaactcctt ctgattctag atcttatggt tcccaaatct     4769

ctctggttct agaactcaga ttttaggctt ttgtttttcc ttttttttgt taaaaaaaaa     4829

aaaatagaga cggggtttca ccatgttgcc caggctggtc gcgaactact gagctcaagc     4889

aattctccct ccttggcctc accaaagtgc tgggactaca ggcatgagcc actgagccca     4949

gccaggcttt ttctaattct atgctttatt ctataaattc ctctgcttct aagcctcaca     5009

gcttccaact gcctttgatt tcagatccaa attcctctga ttctataatt cagcctccaa     5069

atgcttctga ttctggaatc tagacttttc cctaaagatt cctctggttc tgaatcttat     5129

aacctcaact ccctaattcc agaccccagc ctcctaaatc tattctgggc ttcccacccc     5189

actgaactta cccaattcct tctttcagtc ttaagttttc ccattctaaa cccctaccct     5249

ctaggctgtg ctgctcctgg acttcatgcc tctccattct cattgcctac aatctctgtg     5309

ccccagaacc ccctccactt cccaccccag ccctccagac atgcacttac cttgacttta     5369

ccccacatgt ttggggcacc tggggctccc tcaccccttg ggtggtttgc aatctgaaga     5429

cttctccagc cacacaggca catgcacagg cacggtgctg tctgcatatt gccaggtggg     5489

gagagaagcc aggacccctc agctgtctgc caccatctat gtgcctccct taccccccag     5549

ctttctttct acagatggtg ctactcttgg tctcccacag gaaaaggcct ccccccttct     5609

tagccccatt taccccgttt gtggaaggca ctgctcgctc tgttttgtca gagagtggcc     5669

tatccagatt ggtgctatgg gggggtctga cccctccctc ctccctctgg aggtgatgtg     5729

ggccctcaat ggagggaatt gtgctgggct agggaaaggg gagggactag actggccaca     5789

ctggctctga aactcaccaa tctctataca ccataaagac ctcaccttgg taggcaccag     5849

a                                                                     5850


<210>  312
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Ala Leu Gly Leu Gln Arg Ala Arg Ser Thr Thr Glu Leu Arg Lys 
1               5                   10                  15      


Glu Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Gln Glu Thr Glu 
            20                  25                  30          


Val Leu Tyr Gln Leu Ala His Thr Leu Pro Phe Ala Arg Gly Val Ser 
        35                  40                  45              


Ala His Leu Asp Lys Ala Ser Ile Met Arg Leu Thr Ile Ser Tyr Leu 
    50                  55                  60                  


Arg Met His Arg Leu Cys Ala Ala Gly Glu Trp Asn Gln Val Gly Ala 
65                  70                  75                  80  


Gly Gly Glu Pro Leu Asp Ala Cys Tyr Leu Lys Ala Leu Glu Gly Phe 
                85                  90                  95      


Val Met Val Leu Thr Ala Glu Gly Asp Met Ala Tyr Leu Ser Glu Asn 
            100                 105                 110         


Val Ser Lys His Leu Gly Leu Ser Gln Leu Glu Leu Ile Gly His Ser 
        115                 120                 125             


Ile Phe Asp Phe Ile His Pro Cys Asp Gln Glu Glu Leu Gln Asp Ala 
    130                 135                 140                 


Leu Thr Pro Gln Gln Thr Leu Ser Arg Arg Lys Val Glu Ala Pro Thr 
145                 150                 155                 160 


Glu Arg Cys Phe Ser Leu Arg Met Lys Ser Thr Leu Thr Ser Arg Gly 
                165                 170                 175     


Arg Thr Leu Asn Leu Lys Ala Ala Thr Trp Lys Val Leu Asn Cys Ser 
            180                 185                 190         


Gly His Met Arg Ala Tyr Lys Pro Pro Ala Gln Thr Ser Pro Ala Gly 
        195                 200                 205             


Ser Pro Asp Ser Glu Pro Pro Leu Gln Cys Leu Val Leu Ile Cys Glu 
    210                 215                 220                 


Ala Ile Pro His Pro Gly Ser Leu Glu Pro Pro Leu Gly Arg Gly Ala 
225                 230                 235                 240 


Phe Leu Ser Arg His Ser Leu Asp Met Lys Phe Thr Tyr Cys Asp Asp 
                245                 250                 255     


Arg Ile Ala Glu Val Ala Gly Tyr Ser Pro Asp Asp Leu Ile Gly Cys 
            260                 265                 270         


Ser Ala Tyr Glu Tyr Ile His Ala Leu Asp Ser Asp Ala Val Ser Lys 
        275                 280                 285             


Ser Ile His Thr Leu Leu Ser Lys Gly Gln Ala Val Thr Gly Gln Tyr 
    290                 295                 300                 


Arg Phe Leu Ala Arg Ser Gly Gly Tyr Leu Trp Thr Gln Thr Gln Ala 
305                 310                 315                 320 


Thr Val Val Ser Gly Gly Arg Gly Pro Gln Ser Glu Ser Ile Val Cys 
                325                 330                 335     


Val His Phe Leu Ile Ser Gln Val Glu Glu Thr Gly Val Val Leu Ser 
            340                 345                 350         


Leu Glu Gln Thr Glu Gln His Ser Arg Arg Pro Ile Gln Arg Gly Ala 
        355                 360                 365             


Pro Ser Gln Lys Asp Thr Pro Asn Pro Gly Asp Ser Leu Asp Thr Pro 
    370                 375                 380                 


Gly Pro Arg Ile Leu Ala Phe Leu His Pro Pro Ser Leu Ser Glu Ala 
385                 390                 395                 400 


Ala Leu Ala Ala Asp Pro Arg Arg Phe Cys Ser Pro Asp Leu Arg Arg 
                405                 410                 415     


Leu Leu Gly Pro Ile Leu Asp Gly Ala Ser Val Ala Ala Thr Pro Ser 
            420                 425                 430         


Thr Pro Leu Ala Thr Arg His Pro Gln Ser Pro Leu Ser Ala Asp Leu 
        435                 440                 445             


Pro Asp Glu Leu Pro Val Gly Thr Glu Asn Val His Arg Leu Phe Thr 
    450                 455                 460                 


Ser Gly Lys Asp Thr Glu Ala Val Glu Thr Asp Leu Asp Ile Ala Gln 
465                 470                 475                 480 


Asp Ala Asp Ala Leu Asp Leu Glu Met Leu Ala Pro Tyr Ile Ser Met 
                485                 490                 495     


Asp Asp Asp Phe Gln Leu Asn Ala Ser Glu Gln Leu Pro Arg Ala Tyr 
            500                 505                 510         


His Arg Pro Leu Gly Ala Val Pro Arg Pro Arg Ala Arg Ser Phe His 
        515                 520                 525             


Gly Leu Ser Pro Pro Ala Leu Glu Pro Ser Leu Leu Pro Arg Trp Gly 
    530                 535                 540                 


Ser Asp Pro Arg Leu Ser Cys Ser Ser Pro Ser Arg Gly Asp Pro Ser 
545                 550                 555                 560 


Ala Ser Ser Pro Met Ala Gly Ala Arg Lys Arg Thr Leu Ala Gln Ser 
                565                 570                 575     


Ser Glu Asp Glu Asp Glu Gly Val Glu Leu Leu Gly Val Arg Pro Pro 
            580                 585                 590         


Lys Arg Ser Pro Ser Pro Glu His Glu Asn Phe Leu Leu Phe Pro Leu 
        595                 600                 605             


Ser Leu Ser Phe Leu Leu Thr Gly Gly Pro Ala Pro Gly Ser Leu Gln 
    610                 615                 620                 


Asp Pro Ser Thr Pro Leu Leu Asn Leu Asn Glu Pro Leu Gly Leu Gly 
625                 630                 635                 640 


Pro Ser Leu Leu Ser Pro Tyr Ser Asp Glu Asp Thr Thr Gln Pro Gly 
                645                 650                 655     


Gly Pro Phe Gln Pro Arg Ala Gly Ser Ala Gln Ala Asp 
            660                 665                 


<210>  313
<211>  2358
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (129)..(1652)

<400>  313
ggcctcttag gctaggtcag aaaggaggcg gaactcggtg atctgactgg cggtttcccg       60

gccggactga gaaggggagc gcgctgcgcg tcgcaggagt aacctacttg gtctcctgct      120

ttcgcgac atg gcc ttc aat ttt ggg gct ccc tcg ggc acc tcc ggt acc       170
         Met Ala Phe Asn Phe Gly Ala Pro Ser Gly Thr Ser Gly Thr          
         1               5                   10                           

gct gca gcc acc gcg gcc ccc gcg ggt ggg ttt gga gga ttt ggg aca        218
Ala Ala Ala Thr Ala Ala Pro Ala Gly Gly Phe Gly Gly Phe Gly Thr           
15                  20                  25                  30            

aca tct aca act gca ggt tct gca ttc agc ttt tct gcc cca act aac        266
Thr Ser Thr Thr Ala Gly Ser Ala Phe Ser Phe Ser Ala Pro Thr Asn           
                35                  40                  45                

aca ggc act act gga ctc ttt ggt ggt act cag aac aaa ggt ttt gga        314
Thr Gly Thr Thr Gly Leu Phe Gly Gly Thr Gln Asn Lys Gly Phe Gly           
            50                  55                  60                    

ttt ggt act ggt ttt ggc aca aca acg gga act agt act ggt tta ggt        362
Phe Gly Thr Gly Phe Gly Thr Thr Thr Gly Thr Ser Thr Gly Leu Gly           
        65                  70                  75                        

act ggt ttg gga act gga ctg gga ttt gga gga ttt aat aca cag cag        410
Thr Gly Leu Gly Thr Gly Leu Gly Phe Gly Gly Phe Asn Thr Gln Gln           
    80                  85                  90                            

cag cag caa act aca tta ggt ggt ctc ttc agt cag cct aca caa gct        458
Gln Gln Gln Thr Thr Leu Gly Gly Leu Phe Ser Gln Pro Thr Gln Ala           
95                  100                 105                 110           

cct acc cag tcc aac cag ctg ata aat act gcg agt gct ctt tct gct        506
Pro Thr Gln Ser Asn Gln Leu Ile Asn Thr Ala Ser Ala Leu Ser Ala           
                115                 120                 125               

cca acg ctg ttg gga gat gag aga gat gct att ttg gca aaa tgg aat        554
Pro Thr Leu Leu Gly Asp Glu Arg Asp Ala Ile Leu Ala Lys Trp Asn           
            130                 135                 140                   

caa ctg cag gcc ttt tgg gga aca gga aaa ggg tat ttc aac aat aat        602
Gln Leu Gln Ala Phe Trp Gly Thr Gly Lys Gly Tyr Phe Asn Asn Asn           
        145                 150                 155                       

att ccg cca gtg gaa ttc aca caa gaa aat ccc ttt tgc cga ttt aag        650
Ile Pro Pro Val Glu Phe Thr Gln Glu Asn Pro Phe Cys Arg Phe Lys           
    160                 165                 170                           

gca gta ggt tat agt tgc atg ccc agt aat aaa gat gaa gat ggg cta        698
Ala Val Gly Tyr Ser Cys Met Pro Ser Asn Lys Asp Glu Asp Gly Leu           
175                 180                 185                 190           

gtg gtt tta gtt ttc aac aaa aaa gaa aca gag att cga agc caa caa        746
Val Val Leu Val Phe Asn Lys Lys Glu Thr Glu Ile Arg Ser Gln Gln           
                195                 200                 205               

caa cag ttg gta gaa tca ttg cat aaa gtt ttg gga gga aac cag acc        794
Gln Gln Leu Val Glu Ser Leu His Lys Val Leu Gly Gly Asn Gln Thr           
            210                 215                 220                   

ctt act gta aat gta gag ggc act aaa aca ttg cca gat gat cag aca        842
Leu Thr Val Asn Val Glu Gly Thr Lys Thr Leu Pro Asp Asp Gln Thr           
        225                 230                 235                       

gaa gtt gtt att tat gtt gtt gag cgt tcg cca aat ggt act tca aga        890
Glu Val Val Ile Tyr Val Val Glu Arg Ser Pro Asn Gly Thr Ser Arg           
    240                 245                 250                           

aga gtt cca gct aca acg cta tat gcc cat ttt gaa caa gcc aat ata        938
Arg Val Pro Ala Thr Thr Leu Tyr Ala His Phe Glu Gln Ala Asn Ile           
255                 260                 265                 270           

aaa aca caa ttg cag caa ctt ggt gta acc ctt tct atg act aga aca        986
Lys Thr Gln Leu Gln Gln Leu Gly Val Thr Leu Ser Met Thr Arg Thr           
                275                 280                 285               

gaa ctt tct cct gca cag atc aaa cag ctt tta cag aat cct cct gct       1034
Glu Leu Ser Pro Ala Gln Ile Lys Gln Leu Leu Gln Asn Pro Pro Ala           
            290                 295                 300                   

ggt gtt gat cct att atc tgg gaa cag gcc aag gta gat aac cct gat       1082
Gly Val Asp Pro Ile Ile Trp Glu Gln Ala Lys Val Asp Asn Pro Asp           
        305                 310                 315                       

tct gaa aag tta att cct gta cca atg gtg ggt ttt aag gaa ctt ctc       1130
Ser Glu Lys Leu Ile Pro Val Pro Met Val Gly Phe Lys Glu Leu Leu           
    320                 325                 330                           

cga aga ctg aag gtt caa gat cag atg act aag cag cat caa acc aga       1178
Arg Arg Leu Lys Val Gln Asp Gln Met Thr Lys Gln His Gln Thr Arg           
335                 340                 345                 350           

tta gat atc ata tct gaa gat att agt gag cta caa aag aat caa act       1226
Leu Asp Ile Ile Ser Glu Asp Ile Ser Glu Leu Gln Lys Asn Gln Thr           
                355                 360                 365               

aca tct gta gcc aaa att gca caa tac aag agg aaa ctc atg gat ctt       1274
Thr Ser Val Ala Lys Ile Ala Gln Tyr Lys Arg Lys Leu Met Asp Leu           
            370                 375                 380                   

tcc cat aga act tta cag gtc cta atc aaa cag gaa att caa agg aag       1322
Ser His Arg Thr Leu Gln Val Leu Ile Lys Gln Glu Ile Gln Arg Lys           
        385                 390                 395                       

agt ggt tat gcc att cag gct gat gaa gag cag ttg cga gtt cag ctg       1370
Ser Gly Tyr Ala Ile Gln Ala Asp Glu Glu Gln Leu Arg Val Gln Leu           
    400                 405                 410                           

gat acg att cag ggt gaa cta aat gca cct act cag ttc aag ggc cga       1418
Asp Thr Ile Gln Gly Glu Leu Asn Ala Pro Thr Gln Phe Lys Gly Arg           
415                 420                 425                 430           

cta aat gaa ttg atg tct caa atc agg atg cag aat cat ttt gga gca       1466
Leu Asn Glu Leu Met Ser Gln Ile Arg Met Gln Asn His Phe Gly Ala           
                435                 440                 445               

gtc aga tct gaa gaa agg tat tac ata gat gca gat ctg tta cga gaa       1514
Val Arg Ser Glu Glu Arg Tyr Tyr Ile Asp Ala Asp Leu Leu Arg Glu           
            450                 455                 460                   

atc aag cag cat ttg aaa caa caa cag gaa ggc ctt agc cat ttg att       1562
Ile Lys Gln His Leu Lys Gln Gln Gln Glu Gly Leu Ser His Leu Ile           
        465                 470                 475                       

agc atc att aaa gac gat cta gaa gat ata aag ctg gtc gaa cat gga       1610
Ser Ile Ile Lys Asp Asp Leu Glu Asp Ile Lys Leu Val Glu His Gly           
    480                 485                 490                           

ttg aat gaa acc atc cac atc aga ggt ggt gtc ttt agt tga               1652
Leu Asn Glu Thr Ile His Ile Arg Gly Gly Val Phe Ser                       
495                 500                 505                               

cagttcacaa acttgtgtaa aggtttgtga aatgcatctt cttactgcat cagaccttcc     1712

ttaagaatga aaccgaccac atggagggaa aaagaaaaca attctttctt ggattggttt     1772

tttgagaagt ttactgacaa attactgttc atcaaatctg aaatagtcac ctcacagctc     1832

ttcaaagaaa acctttgaaa gatttatatc taaaagctgt atttacttta aaagaagtgc     1892

ataattacca aaattgtatg tactattgta catttttaca acagcatttt cttaaacata     1952

atctgtgttt aatgattatt gtccattgag cctgtactct gctttccata ccaagtaaat     2012

atgaaataat ctactttgca cataacagaa caaactataa ttacttggct gttggagatt     2072

tgtacttgag tataaatgta caccagtttt tgtatttgtg aactcatctg tgggaggagt     2132

aaagaaaatc caaaagcatt taatgttttg tttttgttct ataaagatat gaaaatgtat     2192

ttttatatta ttttacttat ttggaattta cagagcacac ctaagcaatt aggatataac     2252

aaaactactt aaccattttt gcaaccattt tgttttttaa gcctttttat ttctaaaaag     2312

atgaaaactt ataaataaat tcttaatttg taattacttt taaaaa                    2358


<210>  314
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Ala Phe Asn Phe Gly Ala Pro Ser Gly Thr Ser Gly Thr Ala Ala 
1               5                   10                  15      


Ala Thr Ala Ala Pro Ala Gly Gly Phe Gly Gly Phe Gly Thr Thr Ser 
            20                  25                  30          


Thr Thr Ala Gly Ser Ala Phe Ser Phe Ser Ala Pro Thr Asn Thr Gly 
        35                  40                  45              


Thr Thr Gly Leu Phe Gly Gly Thr Gln Asn Lys Gly Phe Gly Phe Gly 
    50                  55                  60                  


Thr Gly Phe Gly Thr Thr Thr Gly Thr Ser Thr Gly Leu Gly Thr Gly 
65                  70                  75                  80  


Leu Gly Thr Gly Leu Gly Phe Gly Gly Phe Asn Thr Gln Gln Gln Gln 
                85                  90                  95      


Gln Thr Thr Leu Gly Gly Leu Phe Ser Gln Pro Thr Gln Ala Pro Thr 
            100                 105                 110         


Gln Ser Asn Gln Leu Ile Asn Thr Ala Ser Ala Leu Ser Ala Pro Thr 
        115                 120                 125             


Leu Leu Gly Asp Glu Arg Asp Ala Ile Leu Ala Lys Trp Asn Gln Leu 
    130                 135                 140                 


Gln Ala Phe Trp Gly Thr Gly Lys Gly Tyr Phe Asn Asn Asn Ile Pro 
145                 150                 155                 160 


Pro Val Glu Phe Thr Gln Glu Asn Pro Phe Cys Arg Phe Lys Ala Val 
                165                 170                 175     


Gly Tyr Ser Cys Met Pro Ser Asn Lys Asp Glu Asp Gly Leu Val Val 
            180                 185                 190         


Leu Val Phe Asn Lys Lys Glu Thr Glu Ile Arg Ser Gln Gln Gln Gln 
        195                 200                 205             


Leu Val Glu Ser Leu His Lys Val Leu Gly Gly Asn Gln Thr Leu Thr 
    210                 215                 220                 


Val Asn Val Glu Gly Thr Lys Thr Leu Pro Asp Asp Gln Thr Glu Val 
225                 230                 235                 240 


Val Ile Tyr Val Val Glu Arg Ser Pro Asn Gly Thr Ser Arg Arg Val 
                245                 250                 255     


Pro Ala Thr Thr Leu Tyr Ala His Phe Glu Gln Ala Asn Ile Lys Thr 
            260                 265                 270         


Gln Leu Gln Gln Leu Gly Val Thr Leu Ser Met Thr Arg Thr Glu Leu 
        275                 280                 285             


Ser Pro Ala Gln Ile Lys Gln Leu Leu Gln Asn Pro Pro Ala Gly Val 
    290                 295                 300                 


Asp Pro Ile Ile Trp Glu Gln Ala Lys Val Asp Asn Pro Asp Ser Glu 
305                 310                 315                 320 


Lys Leu Ile Pro Val Pro Met Val Gly Phe Lys Glu Leu Leu Arg Arg 
                325                 330                 335     


Leu Lys Val Gln Asp Gln Met Thr Lys Gln His Gln Thr Arg Leu Asp 
            340                 345                 350         


Ile Ile Ser Glu Asp Ile Ser Glu Leu Gln Lys Asn Gln Thr Thr Ser 
        355                 360                 365             


Val Ala Lys Ile Ala Gln Tyr Lys Arg Lys Leu Met Asp Leu Ser His 
    370                 375                 380                 


Arg Thr Leu Gln Val Leu Ile Lys Gln Glu Ile Gln Arg Lys Ser Gly 
385                 390                 395                 400 


Tyr Ala Ile Gln Ala Asp Glu Glu Gln Leu Arg Val Gln Leu Asp Thr 
                405                 410                 415     


Ile Gln Gly Glu Leu Asn Ala Pro Thr Gln Phe Lys Gly Arg Leu Asn 
            420                 425                 430         


Glu Leu Met Ser Gln Ile Arg Met Gln Asn His Phe Gly Ala Val Arg 
        435                 440                 445             


Ser Glu Glu Arg Tyr Tyr Ile Asp Ala Asp Leu Leu Arg Glu Ile Lys 
    450                 455                 460                 


Gln His Leu Lys Gln Gln Gln Glu Gly Leu Ser His Leu Ile Ser Ile 
465                 470                 475                 480 


Ile Lys Asp Asp Leu Glu Asp Ile Lys Leu Val Glu His Gly Leu Asn 
                485                 490                 495     


Glu Thr Ile His Ile Arg Gly Gly Val Phe Ser 
            500                 505         


<210>  315
<211>  3429
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (134)..(2734)

<400>  315
ctgggcccgg gctggaagcc ggaagcgagc aaagtggagc cgactcgaac tccaccgcgg       60

aaaagaaagc ctcagaacgt tcgttcgctg cgtccccagc cggggccgag ccctccgcga      120

cgccagccgg gcc atg ggg gcc gca cgc agc ccg ccg tcc gct gtc ccg         169
               Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro            
               1               5                   10                     

ggg ccc ctg ctg ggg ctg ctc ctg ctg ctc ctg ggc gtg ctg gcc ccg        217
Gly Pro Leu Leu Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro           
        15                  20                  25                        

ggt ggc gcc tcc ctg cga ctc ctg gac cac cgg gcg ctg gtc tgc tcc        265
Gly Gly Ala Ser Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser           
    30                  35                  40                            

cag ccg ggg cta aac tgc acg gtc aag aat agt acc tgc ctg gat gac        313
Gln Pro Gly Leu Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp           
45                  50                  55                  60            

agc tgg att cac cct cga aac ctg acc ccc tcc tcc cca aag gac ctg        361
Ser Trp Ile His Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu           
                65                  70                  75                

cag atc cag ctg cac ttt gcc cac acc caa caa gga gac ctg ttc ccc        409
Gln Ile Gln Leu His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro           
            80                  85                  90                    

gtg gct cac atc gaa tgg aca ctg cag aca gac gcc agc atc ctg tac        457
Val Ala His Ile Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr           
        95                  100                 105                       

ctc gag ggt gca gag tta tct gtc ctg cag ctg aac acc aat gaa cgt        505
Leu Glu Gly Ala Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg           
    110                 115                 120                           

ttg tgc gtc agg ttt gag ttt ctg tcc aaa ctg agg cat cac cac agg        553
Leu Cys Val Arg Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg           
125                 130                 135                 140           

cgg tgg cgt ttt acc ttc agc cac ttt gtg gtt gac cct gac cag gaa        601
Arg Trp Arg Phe Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu           
                145                 150                 155               

tat gag gtg acc gtt cac cac ctg ccc aag ccc atc cct gat ggg gac        649
Tyr Glu Val Thr Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp           
            160                 165                 170                   

cca aac cac cag tcc aag aat ttc ctt gtg cct gac tgt gag cac gcc        697
Pro Asn His Gln Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala           
        175                 180                 185                       

agg atg aag gta acc acg cca tgc atg agc tca ggc agc ctg tgg gac        745
Arg Met Lys Val Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp           
    190                 195                 200                           

ccc aac atc acc gtg gag acc ctg gag gcc cac cag ctg cgt gtg agc        793
Pro Asn Ile Thr Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser           
205                 210                 215                 220           

ttc acc ctg tgg aac gaa tct acc cat tac cag atc ctg ctg acc agt        841
Phe Thr Leu Trp Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser           
                225                 230                 235               

ttt ccg cac atg gag aac cac agt tgc ttt gag cac atg cac cac ata        889
Phe Pro His Met Glu Asn His Ser Cys Phe Glu His Met His His Ile           
            240                 245                 250                   

cct gcg ccc aga cca gaa gag ttc cac cag cga tcc aac gtc aca ctc        937
Pro Ala Pro Arg Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu           
        255                 260                 265                       

act cta cgc aac ctt aaa ggg tgc tgt cgc cac caa gtg cag atc cag        985
Thr Leu Arg Asn Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln           
    270                 275                 280                           

ccc ttc ttc agc agc tgc ctc aat gac tgc ctc aga cac tcc gcg act       1033
Pro Phe Phe Ser Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr           
285                 290                 295                 300           

gtt tcc tgc cca gaa atg cca gac act cca gaa cca att ccg gac tac       1081
Val Ser Cys Pro Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr           
                305                 310                 315               

atg ccc ctg tgg gtg tac tgg ttc atc acg ggc atc tcc atc ctg ctg       1129
Met Pro Leu Trp Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu           
            320                 325                 330                   

gtg ggc tcc gtc atc ctg ctc atc gtc tgc atg acc tgg agg cta gct       1177
Val Gly Ser Val Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala           
        335                 340                 345                       

ggg cct gga agt gaa aaa tac agt gat gac acc aaa tac acc gat ggc       1225
Gly Pro Gly Ser Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly           
    350                 355                 360                           

ctg cct gcg gct gac ctg atc ccc cca ccg ctg aag ccc agg aag gtc       1273
Leu Pro Ala Ala Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val           
365                 370                 375                 380           

tgg atc atc tac tca gcc gac cac ccc ctc tac gtg gac gtg gtc ctg       1321
Trp Ile Ile Tyr Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu           
                385                 390                 395               

aaa ttc gcc cag ttc ctg ctc acc gcc tgc ggc acg gaa gtg gcc ctg       1369
Lys Phe Ala Gln Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu           
            400                 405                 410                   

gac ctg ctg gaa gag cag gcc atc tcg gag gca gga gtc atg acc tgg       1417
Asp Leu Leu Glu Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp           
        415                 420                 425                       

gtg ggc cgt cag aag cag gag atg gtg gag agc aac tct aag atc atc       1465
Val Gly Arg Gln Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile           
    430                 435                 440                           

gtc ctg tgc tcc cgc ggc acg cgc gcc aag tgg cag gcg ctc ctg ggc       1513
Val Leu Cys Ser Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly           
445                 450                 455                 460           

cgg ggg gcg cct gtg cgg ctg cgc tgc gac cac gga aag ccc gtg ggg       1561
Arg Gly Ala Pro Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly           
                465                 470                 475               

gac ctg ttc act gca gcc atg aac atg atc ctc ccg gac ttc aag agg       1609
Asp Leu Phe Thr Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg           
            480                 485                 490                   

cca gcc tgc ttc ggc acc tac gta gtc tgc tac ttc agc gag gtc agc       1657
Pro Ala Cys Phe Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser           
        495                 500                 505                       

tgt gac ggc gac gtc ccc gac ctg ttc ggc gcg gcg ccg cgg tac ccg       1705
Cys Asp Gly Asp Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro           
    510                 515                 520                           

ctc atg gac agg ttc gag gag gtg tac ttc cgc atc cag gac ctg gag       1753
Leu Met Asp Arg Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu           
525                 530                 535                 540           

atg ttc cag ccg ggc cgc atg cac cgc gta ggg gag ctg tcg ggg gac       1801
Met Phe Gln Pro Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp           
                545                 550                 555               

aac tac ctg cgg agc ccg ggc ggc agg cag ctc cgc gcc gcc ctg gac       1849
Asn Tyr Leu Arg Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp           
            560                 565                 570                   

agg ttc cgg gac tgg cag gtc cgc tgt ccc gac tgg ttc gaa tgt gag       1897
Arg Phe Arg Asp Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu           
        575                 580                 585                       

aac ctc tac tca gca gat gac cag gat gcc ccg tcc ctg gac gaa gag       1945
Asn Leu Tyr Ser Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu           
    590                 595                 600                           

gtg ttt gag gag cca ctg ctg cct ccg gga acc ggc atc gtg aag cgg       1993
Val Phe Glu Glu Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg           
605                 610                 615                 620           

gcg ccc ctg gtg cgc gag cct ggc tcc cag gcc tgc ctg gcc ata gac       2041
Ala Pro Leu Val Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp           
                625                 630                 635               

ccg ctg gtc ggg gag gaa gga gga gca gca gtg gca aag ctg gaa cct       2089
Pro Leu Val Gly Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro           
            640                 645                 650                   

cac ctg cag ccc cgg ggt cag cca gcg ccg cag ccc ctc cac acc ctg       2137
His Leu Gln Pro Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu           
        655                 660                 665                       

gtg ctc gcc gca gag gag ggg gcc ctg gtg gcc gcg gtg gag cct ggg       2185
Val Leu Ala Ala Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly           
    670                 675                 680                           

ccc ctg gct gac ggt gcc gca gtc cgg ctg gca ctg gcg ggg gag ggc       2233
Pro Leu Ala Asp Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly           
685                 690                 695                 700           

gag gcc tgc ccg ctg ctg ggc agc ccg ggc gct ggg cga aat agc gtc       2281
Glu Ala Cys Pro Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val           
                705                 710                 715               

ctc ttc ctc ccc gtg gac ccc gag gac tcg ccc ctt ggc agc agc acc       2329
Leu Phe Leu Pro Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr           
            720                 725                 730                   

ccc atg gcg tct cct gac ctc ctt cca gag gac gtg agg gag cac ctc       2377
Pro Met Ala Ser Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu           
        735                 740                 745                       

gaa ggc ttg atg ctc tcg ctc ttc gag cag agt ctg agc tgc cag gcc       2425
Glu Gly Leu Met Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala           
    750                 755                 760                           

cag ggg ggc tgc agt aga ccc gcc atg gtc ctc aca gac cca cac acg       2473
Gln Gly Gly Cys Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr           
765                 770                 775                 780           

ccc tac gag gag gag cag cgg cag tca gtg cag tct gac cag ggc tac       2521
Pro Tyr Glu Glu Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr           
                785                 790                 795               

atc tcc agg agc tcc ccg cag ccc ccc gag gga ctc acg gaa atg gag       2569
Ile Ser Arg Ser Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu           
            800                 805                 810                   

gaa gag gag gaa gag gag cag gac cca ggg aag ccg gcc ctg cca ctc       2617
Glu Glu Glu Glu Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu           
        815                 820                 825                       

tct ccc gag gac ctg gag agc ctg agg agc ctc cag cgg cag ctg ctt       2665
Ser Pro Glu Asp Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu           
    830                 835                 840                           

ttc cgc cag ctg cag aag aac tcg ggc tgg gac acg atg ggg tca gag       2713
Phe Arg Gln Leu Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu           
845                 850                 855                 860           

tca gag ggg ccc agt gca tga gggcggctcc ccagggaccg cccagatccc          2764
Ser Glu Gly Pro Ser Ala                                                   
                865                                                       

agctttgaga gaggagtgtg tgtgcacgta ttcatctgtg tgtacatgtc tgcatgtgta     2824

tatgttcgtg tgtgaaatgt aggctttaaa atgtaaatgt ctggatttta atcccaggca     2884

tccctcctaa cttttctttg tgcagcggtc tggttatcgt ctatccccag gggaatccac     2944

acagcccgct cccaggagct aatggtagag cgtccttgag gctccattat tcgttcattc     3004

agcatttatt gtgcacctac tatgtggcgg gcatttggga taccaagata aattgcatgc     3064

ggcatggccc cagccatgaa ggaacttaac cgctagtgcc gaggacacgt taaacgaaca     3124

ggatgggccg ggcacggtgg ctcacgcctg taatcccagc acactgggag gccgaggcag     3184

gtggatcact ctgaggtcag gagtttgagc cagcctggcc aacatggtga aaccccatct     3244

ccactaaaaa tagaaaaatt agccgggcat ggtgacacat gcctgtagtc ctagctactt     3304

gggaggctga ggcaggagaa ttgcttgaat ctgggaggca gaggttgcag tgagccgaga     3364

ttgtgccatt gcactgcagc ctggatgaca gagcgagact ctatctcaaa aaaaaaaaaa     3424

aaaaa                                                                 3429


<210>  316
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
                325                 330                 335     


Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser 
            340                 345                 350         


Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala 
        355                 360                 365             


Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr 
    370                 375                 380                 


Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu 
                405                 410                 415     


Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln 
            420                 425                 430         


Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser 
        435                 440                 445             


Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro 
    450                 455                 460                 


Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr 
465                 470                 475                 480 


Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe 
                485                 490                 495     


Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp 
            500                 505                 510         


Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg 
        515                 520                 525             


Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro 
    530                 535                 540                 


Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg 
545                 550                 555                 560 


Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp 
                565                 570                 575     


Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser 
            580                 585                 590         


Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu 
        595                 600                 605             


Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val 
    610                 615                 620                 


Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly 
625                 630                 635                 640 


Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro 
                645                 650                 655     


Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala 
            660                 665                 670         


Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp 
        675                 680                 685             


Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro 
    690                 695                 700                 


Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro 
705                 710                 715                 720 


Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser 
                725                 730                 735     


Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met 
            740                 745                 750         


Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys 
        755                 760                 765             


Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu 
    770                 775                 780                 


Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser 
785                 790                 795                 800 


Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp 
            820                 825                 830         


Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu 
        835                 840                 845             


Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro 
    850                 855                 860                 


Ser Ala 
865     


<210>  317
<211>  2568
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (227)..(1594)

<400>  317
gagagggagg ctgctgaacc cgagctggtg tgagcttctc ttgccgtaag tccacgggtg       60

gccaggagca cgtgttagtc tggttaagag ctctgctcag aagtagccgc tgcagctgaa      120

ggttttcagg cgggctgaag gctgggccgc ttcttcattc atttcagaaa cttgaacagt      180

gggccttcta cacacgctgt ctttgtcagc ctcaggcagt tcctcc atg gat gag         235
                                                   Met Asp Glu            
                                                   1                      

aca cag ggg cct ctg gcc atg act gtc cat ctt ctt gcc aac tct ggg        283
Thr Gln Gly Pro Leu Ala Met Thr Val His Leu Leu Ala Asn Ser Gly           
    5                   10                  15                            

cac ggc tcc ctt ctg cag agg act ctg gac cag ctc ctg gat tgc att        331
His Gly Ser Leu Leu Gln Arg Thr Leu Asp Gln Leu Leu Asp Cys Ile           
20                  25                  30                  35            

tgc cca gag gtc cgg ctc ttt cag gtg tct gaa cgg gcc agt cct gtg        379
Cys Pro Glu Val Arg Leu Phe Gln Val Ser Glu Arg Ala Ser Pro Val           
                40                  45                  50                

aaa tac tgt gaa aag tcc cat tcc aag cgg tcc cgg ttt cca ggg atg        427
Lys Tyr Cys Glu Lys Ser His Ser Lys Arg Ser Arg Phe Pro Gly Met           
            55                  60                  65                    

tcc gtg ttg ctc ttc ctg cac gaa agc ccg gga gag gat agg cta ttt        475
Ser Val Leu Leu Phe Leu His Glu Ser Pro Gly Glu Asp Arg Leu Phe           
        70                  75                  80                        

cgc gtc ctg gac tct ctc cag cat tcg cca tgg cag tgc tac ccc acc        523
Arg Val Leu Asp Ser Leu Gln His Ser Pro Trp Gln Cys Tyr Pro Thr           
    85                  90                  95                            

cag gac act cgg gga agg ctg tgt ccc tac ttt ttt gcc aat cag gag        571
Gln Asp Thr Arg Gly Arg Leu Cys Pro Tyr Phe Phe Ala Asn Gln Glu           
100                 105                 110                 115           

ttc tac agc ctg gac agt cag ctg ccc atc tgg ggg gtg agg cag gtg        619
Phe Tyr Ser Leu Asp Ser Gln Leu Pro Ile Trp Gly Val Arg Gln Val           
                120                 125                 130               

cac tgt ggc tcc gag atc ctg agg gtg acg ctg tac tgc agt ttt gat        667
His Cys Gly Ser Glu Ile Leu Arg Val Thr Leu Tyr Cys Ser Phe Asp           
            135                 140                 145                   

aac tat gaa gac gcc atc aga ctc tac gag atg atc ctg cag aga gaa        715
Asn Tyr Glu Asp Ala Ile Arg Leu Tyr Glu Met Ile Leu Gln Arg Glu           
        150                 155                 160                       

gcg acc ttg caa aag agc aat ttt tgt ttc ttc gtg ctc tat gcc tcc        763
Ala Thr Leu Gln Lys Ser Asn Phe Cys Phe Phe Val Leu Tyr Ala Ser           
    165                 170                 175                           

aag agc ttt gct ctg cag ctc tcc ctg aag cag ctg ccc ccg gga atg        811
Lys Ser Phe Ala Leu Gln Leu Ser Leu Lys Gln Leu Pro Pro Gly Met           
180                 185                 190                 195           

tca gtg gac ccc aaa gag tct tcg gtg ctg cag ttt aag gtt caa gag        859
Ser Val Asp Pro Lys Glu Ser Ser Val Leu Gln Phe Lys Val Gln Glu           
                200                 205                 210               

atc ggc cag tta gtg cct ctg cta ccc aat cca tgc atg cct atc agc        907
Ile Gly Gln Leu Val Pro Leu Leu Pro Asn Pro Cys Met Pro Ile Ser           
            215                 220                 225                   

agc acc agg tgg cag act cag gac tac gat ggc aac aag att ctg ctt        955
Ser Thr Arg Trp Gln Thr Gln Asp Tyr Asp Gly Asn Lys Ile Leu Leu           
        230                 235                 240                       

cag gtt cag ctg aat cca gaa ctt ggt gtt aag aat ggc atc ttg gga       1003
Gln Val Gln Leu Asn Pro Glu Leu Gly Val Lys Asn Gly Ile Leu Gly           
    245                 250                 255                           

gct ggc atg ctt ccc ctg ggc tcc agg ctg act tct gtc tct gca aag       1051
Ala Gly Met Leu Pro Leu Gly Ser Arg Leu Thr Ser Val Ser Ala Lys           
260                 265                 270                 275           

agg acc tca gaa ccc agg agc cag agg aac cag ggc aag agg tcc cag       1099
Arg Thr Ser Glu Pro Arg Ser Gln Arg Asn Gln Gly Lys Arg Ser Gln           
                280                 285                 290               

ggg cat tct ctg gag ctt cct gag ccc agt ggg agc ccc aca tca gac       1147
Gly His Ser Leu Glu Leu Pro Glu Pro Ser Gly Ser Pro Thr Ser Asp           
            295                 300                 305                   

agg tgt gct ggc act tcg tgg aaa agc cct ggc cgg tca ttc cag gtc       1195
Arg Cys Ala Gly Thr Ser Trp Lys Ser Pro Gly Arg Ser Phe Gln Val           
        310                 315                 320                       

agc agc cca gct atg ggt gcc cac ctg cac ctg tct tct cat cac ctt       1243
Ser Ser Pro Ala Met Gly Ala His Leu His Leu Ser Ser His His Leu           
    325                 330                 335                           

gaa tcc ggg gcc aga atg aag gtc ctc aac cgg gaa aac agc ttt cag       1291
Glu Ser Gly Ala Arg Met Lys Val Leu Asn Arg Glu Asn Ser Phe Gln           
340                 345                 350                 355           

aag ctt gag gcc gag acg aat gtt gac acc ggc ttg acc atc ata aat       1339
Lys Leu Glu Ala Glu Thr Asn Val Asp Thr Gly Leu Thr Ile Ile Asn           
                360                 365                 370               

tct gaa ccc agg cag act tat ttt ggc gga ttt cca agg gat tta cag       1387
Ser Glu Pro Arg Gln Thr Tyr Phe Gly Gly Phe Pro Arg Asp Leu Gln           
            375                 380                 385                   

acc agc cag cca cca ttc tgc ttg cca gcc tct tcc ttg ggg gtg gct       1435
Thr Ser Gln Pro Pro Phe Cys Leu Pro Ala Ser Ser Leu Gly Val Ala           
        390                 395                 400                       

acc tcc aaa aac aac agt gtc ctt aag gaa aga gtc tct cct ttg cca       1483
Thr Ser Lys Asn Asn Ser Val Leu Lys Glu Arg Val Ser Pro Leu Pro           
    405                 410                 415                           

ctt gct ggc caa agg gac ctt ggt acc agg aag aca att tca gaa tgt       1531
Leu Ala Gly Gln Arg Asp Leu Gly Thr Arg Lys Thr Ile Ser Glu Cys           
420                 425                 430                 435           

ctc ctt cat ctg caa gtt cag ggt gaa gaa aaa gaa gaa gat gaa gaa       1579
Leu Leu His Leu Gln Val Gln Gly Glu Glu Lys Glu Glu Asp Glu Glu           
                440                 445                 450               

gaa ttc ttt ata tag cataaaataa atgtggtttt ctaaaacaca agatcagata       1634
Glu Phe Phe Ile                                                           
            455                                                           

aaatgttcta gaaatggagt actgacccag aatcagcctg ttagttgttc atctgagggg     1694

ggctgaatgc tccccatgca caatctgtat tgattttatt tcaaatgttc aaagtctaaa     1754

ggtgctggga atgattgttt atttgccgtc acagtcataa gagaacacag ccaacacaca     1814

gggaaaaaaa ccgaatgctt ttgttccgtg gagatgcact aacccagctg gatgtgttga     1874

atccagcacc tatcaggata attgcattgt atgcaaatga atcggtatgt tatacaacac     1934

taattagtgt ctgtaatttg gttttaattt ttacttaggt tgcatagctc atccccctgg     1994

acaatatgga ctgctattta ctcttgaatg ctttttaatt ttcatgtgac ctcttttggt     2054

aactaggcct tgttcacata ccctccttgt gattttgtct ttaaagttgt ttgtatctgg     2114

aatgagtgaa aatgcaaagt gttttgaaaa ttataaacag ttaattttgt tttcctgttt     2174

aatgagccaa aatactggaa gccagaaaat caggttgaac atgaatgcta ggctctaggg     2234

ctttcctgct catctgcttc tcatttgttt ctgcactatg tcaaagagga cagtggttct     2294

tgttacaaac caaagaggaa cattgagcac agtgggaaaa ttggactggt tgatctggtc     2354

actggagcag gacttgggtt cttctggcca gattttgact cccagattcc tttacaaaac     2414

gcactcattc attcatttat atatgttcat tcaataaaca ttttttgaat acctaaaaaa     2474

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2534

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                 2568


<210>  318
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Asp Glu Thr Gln Gly Pro Leu Ala Met Thr Val His Leu Leu Ala 
1               5                   10                  15      


Asn Ser Gly His Gly Ser Leu Leu Gln Arg Thr Leu Asp Gln Leu Leu 
            20                  25                  30          


Asp Cys Ile Cys Pro Glu Val Arg Leu Phe Gln Val Ser Glu Arg Ala 
        35                  40                  45              


Ser Pro Val Lys Tyr Cys Glu Lys Ser His Ser Lys Arg Ser Arg Phe 
    50                  55                  60                  


Pro Gly Met Ser Val Leu Leu Phe Leu His Glu Ser Pro Gly Glu Asp 
65                  70                  75                  80  


Arg Leu Phe Arg Val Leu Asp Ser Leu Gln His Ser Pro Trp Gln Cys 
                85                  90                  95      


Tyr Pro Thr Gln Asp Thr Arg Gly Arg Leu Cys Pro Tyr Phe Phe Ala 
            100                 105                 110         


Asn Gln Glu Phe Tyr Ser Leu Asp Ser Gln Leu Pro Ile Trp Gly Val 
        115                 120                 125             


Arg Gln Val His Cys Gly Ser Glu Ile Leu Arg Val Thr Leu Tyr Cys 
    130                 135                 140                 


Ser Phe Asp Asn Tyr Glu Asp Ala Ile Arg Leu Tyr Glu Met Ile Leu 
145                 150                 155                 160 


Gln Arg Glu Ala Thr Leu Gln Lys Ser Asn Phe Cys Phe Phe Val Leu 
                165                 170                 175     


Tyr Ala Ser Lys Ser Phe Ala Leu Gln Leu Ser Leu Lys Gln Leu Pro 
            180                 185                 190         


Pro Gly Met Ser Val Asp Pro Lys Glu Ser Ser Val Leu Gln Phe Lys 
        195                 200                 205             


Val Gln Glu Ile Gly Gln Leu Val Pro Leu Leu Pro Asn Pro Cys Met 
    210                 215                 220                 


Pro Ile Ser Ser Thr Arg Trp Gln Thr Gln Asp Tyr Asp Gly Asn Lys 
225                 230                 235                 240 


Ile Leu Leu Gln Val Gln Leu Asn Pro Glu Leu Gly Val Lys Asn Gly 
                245                 250                 255     


Ile Leu Gly Ala Gly Met Leu Pro Leu Gly Ser Arg Leu Thr Ser Val 
            260                 265                 270         


Ser Ala Lys Arg Thr Ser Glu Pro Arg Ser Gln Arg Asn Gln Gly Lys 
        275                 280                 285             


Arg Ser Gln Gly His Ser Leu Glu Leu Pro Glu Pro Ser Gly Ser Pro 
    290                 295                 300                 


Thr Ser Asp Arg Cys Ala Gly Thr Ser Trp Lys Ser Pro Gly Arg Ser 
305                 310                 315                 320 


Phe Gln Val Ser Ser Pro Ala Met Gly Ala His Leu His Leu Ser Ser 
                325                 330                 335     


His His Leu Glu Ser Gly Ala Arg Met Lys Val Leu Asn Arg Glu Asn 
            340                 345                 350         


Ser Phe Gln Lys Leu Glu Ala Glu Thr Asn Val Asp Thr Gly Leu Thr 
        355                 360                 365             


Ile Ile Asn Ser Glu Pro Arg Gln Thr Tyr Phe Gly Gly Phe Pro Arg 
    370                 375                 380                 


Asp Leu Gln Thr Ser Gln Pro Pro Phe Cys Leu Pro Ala Ser Ser Leu 
385                 390                 395                 400 


Gly Val Ala Thr Ser Lys Asn Asn Ser Val Leu Lys Glu Arg Val Ser 
                405                 410                 415     


Pro Leu Pro Leu Ala Gly Gln Arg Asp Leu Gly Thr Arg Lys Thr Ile 
            420                 425                 430         


Ser Glu Cys Leu Leu His Leu Gln Val Gln Gly Glu Glu Lys Glu Glu 
        435                 440                 445             


Asp Glu Glu Glu Phe Phe Ile 
    450                 455 


<210>  319
<211>  1710
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (89)..(1090)

<400>  319
cagcagggct cccgcgggcg tcactccggc catcgtcccc acctccacct gggccgcccg       60

gcaggcaggc gacggaggcc cgggagcc atg ggt gac tgg ggc ttc ctg gag         112
                               Met Gly Asp Trp Gly Phe Leu Glu            
                               1               5                          

aag ttg ctg gac cag gtc cag gag cac tcg acc gtg gtg ggt aag atc        160
Lys Leu Leu Asp Gln Val Gln Glu His Ser Thr Val Val Gly Lys Ile           
    10                  15                  20                            

tgg ctg acg gtg ctc ttc atc ttc cgc atc ctc atc ctg ggc ctg gcc        208
Trp Leu Thr Val Leu Phe Ile Phe Arg Ile Leu Ile Leu Gly Leu Ala           
25                  30                  35                  40            

ggc gag tca gtg tgg ggt gac gag caa tca gat ttc gag tgt aac acg        256
Gly Glu Ser Val Trp Gly Asp Glu Gln Ser Asp Phe Glu Cys Asn Thr           
                45                  50                  55                

gcc cag cca ggc tgc acc aac gtc tgc tat gac cag gcc ttc ccc atc        304
Ala Gln Pro Gly Cys Thr Asn Val Cys Tyr Asp Gln Ala Phe Pro Ile           
            60                  65                  70                    

tcc cac atc cgc tac tgg gtg ctg cag ttc ctc ttc gtc agc aca ccc        352
Ser His Ile Arg Tyr Trp Val Leu Gln Phe Leu Phe Val Ser Thr Pro           
        75                  80                  85                        

acc ctg gtc tac ctg ggc cat gtc att tac ctg tct cgg cga gaa gag        400
Thr Leu Val Tyr Leu Gly His Val Ile Tyr Leu Ser Arg Arg Glu Glu           
    90                  95                  100                           

cgg ctg cgg cag aag gag ggg gag ctg cgg gca ctg ccg gcc aag gac        448
Arg Leu Arg Gln Lys Glu Gly Glu Leu Arg Ala Leu Pro Ala Lys Asp           
105                 110                 115                 120           

cca cag gtg gag cgg gcg ctg gcg gcc gta gag cgt cag atg gcc aag        496
Pro Gln Val Glu Arg Ala Leu Ala Ala Val Glu Arg Gln Met Ala Lys           
                125                 130                 135               

atc tcg gtg gca gaa gat ggt cgc ctg cgc atc cgc gga gca ctg atg        544
Ile Ser Val Ala Glu Asp Gly Arg Leu Arg Ile Arg Gly Ala Leu Met           
            140                 145                 150                   

ggc acc tat gtc gcc agt gtg ctc tgc aag agt gtg cta gag gca ggc        592
Gly Thr Tyr Val Ala Ser Val Leu Cys Lys Ser Val Leu Glu Ala Gly           
        155                 160                 165                       

ttc ctc tat ggc cag tgg cgc ctg tac ggc tgg acc atg gag ccc gtg        640
Phe Leu Tyr Gly Gln Trp Arg Leu Tyr Gly Trp Thr Met Glu Pro Val           
    170                 175                 180                           

ttt gtg tgc cag cga gca ccc tgc ccc tac ctc gtg gac tgc ttt gtc        688
Phe Val Cys Gln Arg Ala Pro Cys Pro Tyr Leu Val Asp Cys Phe Val           
185                 190                 195                 200           

tct cgc ccc acg gag aag acc atc ttc atc atc ttc atg ttg gtg gtt        736
Ser Arg Pro Thr Glu Lys Thr Ile Phe Ile Ile Phe Met Leu Val Val           
                205                 210                 215               

gga ctc atc tcc ctg gtg ctt aac ctg ctg gag ttg gtg cac ctg ctg        784
Gly Leu Ile Ser Leu Val Leu Asn Leu Leu Glu Leu Val His Leu Leu           
            220                 225                 230                   

tgt cgc tgc ctc agc cgg ggg atg agg gca cgg caa ggc caa gac gca        832
Cys Arg Cys Leu Ser Arg Gly Met Arg Ala Arg Gln Gly Gln Asp Ala           
        235                 240                 245                       

ccc ccg acc cag ggc acc tcc tca gac cct tac acg gac cag gtc ttc        880
Pro Pro Thr Gln Gly Thr Ser Ser Asp Pro Tyr Thr Asp Gln Val Phe           
    250                 255                 260                           

ttc tac ctc ccc gtg ggc cag ggg ccc tca tcc cca cca tgc ccc acc        928
Phe Tyr Leu Pro Val Gly Gln Gly Pro Ser Ser Pro Pro Cys Pro Thr           
265                 270                 275                 280           

tac aat ggg ctc tca tcc agt gag cag aac tgg gcc aac ctg acc aca        976
Tyr Asn Gly Leu Ser Ser Ser Glu Gln Asn Trp Ala Asn Leu Thr Thr           
                285                 290                 295               

gag gag agg ctg gcg tct tcc agg ccc cct ctc ttc ctg gac cca ccc       1024
Glu Glu Arg Leu Ala Ser Ser Arg Pro Pro Leu Phe Leu Asp Pro Pro           
            300                 305                 310                   

cct cag aat ggc caa aaa ccc cca agt cgt ccc agc agc tct gct tct       1072
Pro Gln Asn Gly Gln Lys Pro Pro Ser Arg Pro Ser Ser Ser Ala Ser           
        315                 320                 325                       

aag aag cag tat gta tag aggcctgtgg cttatgtcac ccaacagagg              1120
Lys Lys Gln Tyr Val                                                       
    330                                                                   

ggtcctgaga agtctggctg cctgggatgc cccctgcccc ctcctggaag gctctgcaga     1180

gatgactggg ctggggaagc aggtgcttgc tggccatgga gcctcattgc aagttgttct     1240

tgaacacctg aggccttcct ggtgcccacc aggcactacg gcttcctctc cagaatgtgg     1300

ctttgcctga gcacagacag agtcagcatg gaatgctctt ggccaagggt actgggggcc     1360

ctctggcctt ttgcagctga tccagaggaa cccagagcca acttacccca acctcaccct     1420

atggaacagt cacctgtgcg caggttgtcc tcaaaccctc tcctcacagg aaaaggcgga     1480

ttgaggctgc tgggtcagcc ttgatcgcac agacagagct tgtgccggat ttggccctgt     1540

caaggggact ggtgccttgt tttcatcact ccttcctagt tctactgttc aagcttctga     1600

aataaacagg acttgatcac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1660

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                1710


<210>  320
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Gly Asp Trp Gly Phe Leu Glu Lys Leu Leu Asp Gln Val Gln Glu 
1               5                   10                  15      


His Ser Thr Val Val Gly Lys Ile Trp Leu Thr Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Ile Leu Gly Leu Ala Gly Glu Ser Val Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Asp Phe Glu Cys Asn Thr Ala Gln Pro Gly Cys Thr Asn Val 
    50                  55                  60                  


Cys Tyr Asp Gln Ala Phe Pro Ile Ser His Ile Arg Tyr Trp Val Leu 
65                  70                  75                  80  


Gln Phe Leu Phe Val Ser Thr Pro Thr Leu Val Tyr Leu Gly His Val 
                85                  90                  95      


Ile Tyr Leu Ser Arg Arg Glu Glu Arg Leu Arg Gln Lys Glu Gly Glu 
            100                 105                 110         


Leu Arg Ala Leu Pro Ala Lys Asp Pro Gln Val Glu Arg Ala Leu Ala 
        115                 120                 125             


Ala Val Glu Arg Gln Met Ala Lys Ile Ser Val Ala Glu Asp Gly Arg 
    130                 135                 140                 


Leu Arg Ile Arg Gly Ala Leu Met Gly Thr Tyr Val Ala Ser Val Leu 
145                 150                 155                 160 


Cys Lys Ser Val Leu Glu Ala Gly Phe Leu Tyr Gly Gln Trp Arg Leu 
                165                 170                 175     


Tyr Gly Trp Thr Met Glu Pro Val Phe Val Cys Gln Arg Ala Pro Cys 
            180                 185                 190         


Pro Tyr Leu Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Ile 
        195                 200                 205             


Phe Ile Ile Phe Met Leu Val Val Gly Leu Ile Ser Leu Val Leu Asn 
    210                 215                 220                 


Leu Leu Glu Leu Val His Leu Leu Cys Arg Cys Leu Ser Arg Gly Met 
225                 230                 235                 240 


Arg Ala Arg Gln Gly Gln Asp Ala Pro Pro Thr Gln Gly Thr Ser Ser 
                245                 250                 255     


Asp Pro Tyr Thr Asp Gln Val Phe Phe Tyr Leu Pro Val Gly Gln Gly 
            260                 265                 270         


Pro Ser Ser Pro Pro Cys Pro Thr Tyr Asn Gly Leu Ser Ser Ser Glu 
        275                 280                 285             


Gln Asn Trp Ala Asn Leu Thr Thr Glu Glu Arg Leu Ala Ser Ser Arg 
    290                 295                 300                 


Pro Pro Leu Phe Leu Asp Pro Pro Pro Gln Asn Gly Gln Lys Pro Pro 
305                 310                 315                 320 


Ser Arg Pro Ser Ser Ser Ala Ser Lys Lys Gln Tyr Val 
                325                 330             


<210>  321
<211>  4451
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (79)..(2634)

<400>  321
gctcatacta gggacgggaa gtcgcgacca gagccattgg agggcgcggg gactgcaacc       60

ctaatcagca gagcccaa atg gcg cag tgg gaa atg ctg cag aat ctt gac        111
                    Met Ala Gln Trp Glu Met Leu Gln Asn Leu Asp           
                    1               5                   10                

agc ccc ttt cag gat cag ctg cac cag ctt tac tcg cac agc ctc ctg        159
Ser Pro Phe Gln Asp Gln Leu His Gln Leu Tyr Ser His Ser Leu Leu           
            15                  20                  25                    

cct gtg gac att cga cag tac ttg gct gtc tgg att gaa gac cag aac        207
Pro Val Asp Ile Arg Gln Tyr Leu Ala Val Trp Ile Glu Asp Gln Asn           
        30                  35                  40                        

tgg cag gaa gct gca ctt ggg agt gat gat tcc aag gct acc atg cta        255
Trp Gln Glu Ala Ala Leu Gly Ser Asp Asp Ser Lys Ala Thr Met Leu           
    45                  50                  55                            

ttc ttc cac ttc ttg gat cag ctg aac tat gag tgt ggc cgt tgc agc        303
Phe Phe His Phe Leu Asp Gln Leu Asn Tyr Glu Cys Gly Arg Cys Ser           
60                  65                  70                  75            

cag gac cca gag tcc ttg ttg ctg cag cac aat ttg cgg aaa ttc tgc        351
Gln Asp Pro Glu Ser Leu Leu Leu Gln His Asn Leu Arg Lys Phe Cys           
                80                  85                  90                

cgg gac att cag ccc ttt tcc cag gat cct acc cag ttg gct gag atg        399
Arg Asp Ile Gln Pro Phe Ser Gln Asp Pro Thr Gln Leu Ala Glu Met           
            95                  100                 105                   

atc ttt aac ctc ctt ctg gaa gaa aaa aga att ttg atc cag gct cag        447
Ile Phe Asn Leu Leu Leu Glu Glu Lys Arg Ile Leu Ile Gln Ala Gln           
        110                 115                 120                       

agg gcc caa ttg gaa caa gga gag cca gtt ctc gaa aca cct gtg gag        495
Arg Ala Gln Leu Glu Gln Gly Glu Pro Val Leu Glu Thr Pro Val Glu           
    125                 130                 135                           

agc cag caa cat gag att gaa tcc cgg atc ctg gat tta agg gct atg        543
Ser Gln Gln His Glu Ile Glu Ser Arg Ile Leu Asp Leu Arg Ala Met           
140                 145                 150                 155           

atg gag aag ctg gta aaa tcc atc agc caa ctg aaa gac cag cag gat        591
Met Glu Lys Leu Val Lys Ser Ile Ser Gln Leu Lys Asp Gln Gln Asp           
                160                 165                 170               

gtc ttc tgc ttc cga tat aag atc cag gcc aaa ggg aag aca ccc tct        639
Val Phe Cys Phe Arg Tyr Lys Ile Gln Ala Lys Gly Lys Thr Pro Ser           
            175                 180                 185                   

ctg gac ccc cat cag acc aaa gag cag aag att ctg cag gaa act ctc        687
Leu Asp Pro His Gln Thr Lys Glu Gln Lys Ile Leu Gln Glu Thr Leu           
        190                 195                 200                       

aat gaa ctg gac aaa agg aga aag gag gtg ctg gat gcc tcc aaa gca        735
Asn Glu Leu Asp Lys Arg Arg Lys Glu Val Leu Asp Ala Ser Lys Ala           
    205                 210                 215                           

ctg cta ggc cga tta act acc cta atc gag cta ctg ctg cca aag ttg        783
Leu Leu Gly Arg Leu Thr Thr Leu Ile Glu Leu Leu Leu Pro Lys Leu           
220                 225                 230                 235           

gag gag tgg aag gcc cag cag caa aaa gcc tgc atc aga gct ccc att        831
Glu Glu Trp Lys Ala Gln Gln Gln Lys Ala Cys Ile Arg Ala Pro Ile           
                240                 245                 250               

gac cac ggg ttg gaa cag ctg gag aca tgg ttc aca gct gga gca aag        879
Asp His Gly Leu Glu Gln Leu Glu Thr Trp Phe Thr Ala Gly Ala Lys           
            255                 260                 265                   

ctg ttg ttt cac ctg agg cag ctg ctg aag gag ctg aag gga ctg agt        927
Leu Leu Phe His Leu Arg Gln Leu Leu Lys Glu Leu Lys Gly Leu Ser           
        270                 275                 280                       

tgc ctg gtt agc tat cag gat gac cct ctg acc aaa ggg gtg gac cta        975
Cys Leu Val Ser Tyr Gln Asp Asp Pro Leu Thr Lys Gly Val Asp Leu           
    285                 290                 295                           

cgc aac gcc cag gtc aca gag ttg cta cag cgt ctg ctc cac aga gcc       1023
Arg Asn Ala Gln Val Thr Glu Leu Leu Gln Arg Leu Leu His Arg Ala           
300                 305                 310                 315           

ttt gtg gta gaa acc cag ccc tgc atg ccc caa act ccc cat cga ccc       1071
Phe Val Val Glu Thr Gln Pro Cys Met Pro Gln Thr Pro His Arg Pro           
                320                 325                 330               

ctc atc ctc aag act ggc agc aag ttc acc gtc cga aca agg ctg ctg       1119
Leu Ile Leu Lys Thr Gly Ser Lys Phe Thr Val Arg Thr Arg Leu Leu           
            335                 340                 345                   

gtg aga ctc cag gaa ggc aat gag tca ctg act gtg gaa gtc tcc att       1167
Val Arg Leu Gln Glu Gly Asn Glu Ser Leu Thr Val Glu Val Ser Ile           
        350                 355                 360                       

gac agg aat cct cct caa tta caa ggc ttc cgg aag ttc aac att ctg       1215
Asp Arg Asn Pro Pro Gln Leu Gln Gly Phe Arg Lys Phe Asn Ile Leu           
    365                 370                 375                           

act tca aac cag aaa act ttg acc ccc gag aag ggg cag agt cag ggt       1263
Thr Ser Asn Gln Lys Thr Leu Thr Pro Glu Lys Gly Gln Ser Gln Gly           
380                 385                 390                 395           

ttg att tgg gac ttt ggt tac ctg act ctg gtg gag caa cgt tca ggt       1311
Leu Ile Trp Asp Phe Gly Tyr Leu Thr Leu Val Glu Gln Arg Ser Gly           
                400                 405                 410               

ggt tca gga aag ggc agc aat aag ggg cca cta ggt gtg aca gag gaa       1359
Gly Ser Gly Lys Gly Ser Asn Lys Gly Pro Leu Gly Val Thr Glu Glu           
            415                 420                 425                   

ctg cac atc atc agc ttc acg gtc aaa tat acc tac cag ggt ctg aag       1407
Leu His Ile Ile Ser Phe Thr Val Lys Tyr Thr Tyr Gln Gly Leu Lys           
        430                 435                 440                       

cag gag ctg aaa acg gac acc ctc cct gtg gtg att att tcc aac atg       1455
Gln Glu Leu Lys Thr Asp Thr Leu Pro Val Val Ile Ile Ser Asn Met           
    445                 450                 455                           

aac cag ctc tca att gcc tgg gct tca gtt ctc tgg ttc aat ttg ctc       1503
Asn Gln Leu Ser Ile Ala Trp Ala Ser Val Leu Trp Phe Asn Leu Leu           
460                 465                 470                 475           

agc cca aac ctt cag aac cag cag ttc ttc tcc aac ccc ccc aag gcc       1551
Ser Pro Asn Leu Gln Asn Gln Gln Phe Phe Ser Asn Pro Pro Lys Ala           
                480                 485                 490               

ccc tgg agc ttg ctg ggc cct gct ctc agt tgg cag ttc tcc tcc tat       1599
Pro Trp Ser Leu Leu Gly Pro Ala Leu Ser Trp Gln Phe Ser Ser Tyr           
            495                 500                 505                   

gtt ggc cga ggc ctc aac tca gac cag ctg agc atg ctg aga aac aag       1647
Val Gly Arg Gly Leu Asn Ser Asp Gln Leu Ser Met Leu Arg Asn Lys           
        510                 515                 520                       

ctg ttc ggg cag aac tgt agg act gag gat cca tta ttg tcc tgg gct       1695
Leu Phe Gly Gln Asn Cys Arg Thr Glu Asp Pro Leu Leu Ser Trp Ala           
    525                 530                 535                           

gac ttc act aag cga gag agc cct cct ggc aag tta cca ttc tgg aca       1743
Asp Phe Thr Lys Arg Glu Ser Pro Pro Gly Lys Leu Pro Phe Trp Thr           
540                 545                 550                 555           

tgg ctg gac aaa att ctg gag ttg gta cat gac cac ctg aag gat ctc       1791
Trp Leu Asp Lys Ile Leu Glu Leu Val His Asp His Leu Lys Asp Leu           
                560                 565                 570               

tgg aat gat gga cgc atc atg ggc ttt gtg agt cgg agc cag gag cgc       1839
Trp Asn Asp Gly Arg Ile Met Gly Phe Val Ser Arg Ser Gln Glu Arg           
            575                 580                 585                   

cgg ctg ctg aag aag acc atg tct ggc acc ttt cta ctg cgc ttc agt       1887
Arg Leu Leu Lys Lys Thr Met Ser Gly Thr Phe Leu Leu Arg Phe Ser           
        590                 595                 600                       

gaa tcg tca gaa ggg ggc att acc tgc tcc tgg gtg gag cac cag gat       1935
Glu Ser Ser Glu Gly Gly Ile Thr Cys Ser Trp Val Glu His Gln Asp           
    605                 610                 615                           

gat gac aag gtg ctc atc tac tct gtg caa ccg tac acg aag gag gtg       1983
Asp Asp Lys Val Leu Ile Tyr Ser Val Gln Pro Tyr Thr Lys Glu Val           
620                 625                 630                 635           

ctg cag tca ctc ccg ctg act gaa atc atc cgc cat tac cag ttg ctc       2031
Leu Gln Ser Leu Pro Leu Thr Glu Ile Ile Arg His Tyr Gln Leu Leu           
                640                 645                 650               

act gag gag aat ata cct gaa aac cca ctg cgc ttc ctc tat ccc cga       2079
Thr Glu Glu Asn Ile Pro Glu Asn Pro Leu Arg Phe Leu Tyr Pro Arg           
            655                 660                 665                   

atc ccc cgg gat gaa gct ttt ggg tgc tac tac cag gag aaa gtt aat       2127
Ile Pro Arg Asp Glu Ala Phe Gly Cys Tyr Tyr Gln Glu Lys Val Asn           
        670                 675                 680                       

ctc cag gaa cgg agg aaa tac ctg aaa cac agg ctc att gtg gtc tct       2175
Leu Gln Glu Arg Arg Lys Tyr Leu Lys His Arg Leu Ile Val Val Ser           
    685                 690                 695                           

aat aga cag gtg gat gaa ctg caa caa ccg ctg gag ctt aag cca gag       2223
Asn Arg Gln Val Asp Glu Leu Gln Gln Pro Leu Glu Leu Lys Pro Glu           
700                 705                 710                 715           

cca gag ctg gag tca tta gag ctg gaa cta ggg ctg gtg cca gag cca       2271
Pro Glu Leu Glu Ser Leu Glu Leu Glu Leu Gly Leu Val Pro Glu Pro           
                720                 725                 730               

gag ctc agc ctg gac tta gag cca ctg ctg aag gca ggg ctg gat ctg       2319
Glu Leu Ser Leu Asp Leu Glu Pro Leu Leu Lys Ala Gly Leu Asp Leu           
            735                 740                 745                   

ggg cca gag cta gag tct gtg ctg gag tcc act ctg gag cct gtg ata       2367
Gly Pro Glu Leu Glu Ser Val Leu Glu Ser Thr Leu Glu Pro Val Ile           
        750                 755                 760                       

gag ccc aca cta tgc atg gta tca caa aca gtg cca gag cca gac caa       2415
Glu Pro Thr Leu Cys Met Val Ser Gln Thr Val Pro Glu Pro Asp Gln           
    765                 770                 775                           

gga cct gta tca cag cca gtg cca gag cca gat ttg ccc tgt gat ctg       2463
Gly Pro Val Ser Gln Pro Val Pro Glu Pro Asp Leu Pro Cys Asp Leu           
780                 785                 790                 795           

aga cat ttg aac act gag cca atg gaa atc ttc aga aac tgt gta aag       2511
Arg His Leu Asn Thr Glu Pro Met Glu Ile Phe Arg Asn Cys Val Lys           
                800                 805                 810               

att gaa gaa atc atg ccg aat ggt gac cca ctg ttg gct ggc cag aac       2559
Ile Glu Glu Ile Met Pro Asn Gly Asp Pro Leu Leu Ala Gly Gln Asn           
            815                 820                 825                   

acc gtg gat gag gtt tac gtc tcc cgc ccc agc cac ttc tac act gat       2607
Thr Val Asp Glu Val Tyr Val Ser Arg Pro Ser His Phe Tyr Thr Asp           
        830                 835                 840                       

gga ccc ttg atg cct tct gac ttc tag gaaccacatt tcctctgttc             2654
Gly Pro Leu Met Pro Ser Asp Phe                                           
    845                 850                                               

ttttcatatc tcttgccctt cctactcctc atagcatgat attgttctcc aaggatggga     2714

atcaggcatg tgtcccttcc aagctgtgtt aactgttcaa actcaggcct gtgtgactcc     2774

attggggtga gaggtgaaag cataacatgg gtacagaggg gacaacaatg aatcagaaca     2834

gatgctgagc cataggtcta aataggatcc tggaggctgc ctgctgtgct gggaggtata     2894

ggggtcctgg gggcaggcca gggcagttga caggtacttg gagggctcag ggcagtggct     2954

tctttccagt atggaaggat ttcaacattt taatagttgg ttaggctaaa ctggtgcata     3014

ctggcattgg cccttggtgg ggagcacaga cacaggatag gactccattt ctttcttcca     3074

ttccttcatg tctaggataa cttgctttct tctttccttt actcctggct caagccctga     3134

atttcttctt ttcctgcagg ggttgagagc tttctgcctt agcctaccat gtgaaactct     3194

accctgaaga aagggatgga taggaagtag acctcttttt cttaccagtc tcctccccta     3254

ctctgcccct aagctggctg tacctgttcc tcccccataa aatgatcctg ccaatctaat     3314

gtgagtgtga agctttgcac actagtttat gctacctagt ctccactttc tcaatgctta     3374

ggagacagat cactcctgga ggctggggat ggtaggattg ctggggattt tttttttttt     3434

aaacagggtc tcactctgtt gcccaggcta gagtgcaatg gtgcaatcac agctcactgc     3494

agcctcaacc tcctgggttc aagcaatcct cctacctcag cctcctgggt agctagcacc     3554

atggcatgcg ccaccatgcc ctattttttt tttttaaaga cagggtcttg ctatattgcc     3614

caggctggtc ttgaactggg ctcaagtgat cctcacgcct tggcctccca aagtgctggg     3674

attataggca tgagccactg tgcttggcca ggattttttt tttttttttt ttgagatgga     3734

gtttctctct tgttgtccag gctggagtgc aatggtgtga tctcggctca ctgcaacctc     3794

cgccttccgg gttcaagtga ctctcctgcc tcagcctccc cagtagctgg gattacagat     3854

ctgcaccacc atgcccagct aattttgtat ttttagtaga gacggggttt ctccatgttg     3914

gtcaggctgg tctcgaactc ctgacctcaa gtgatctgtc cacctcggcc tcccagagtg     3974

ctgggattac aggcgtgagc cactgttccc agcaggaatt tcttttttat agtattggat     4034

aaagtttggt gtttttacag aggagaagca atgggtctta gctctttctc tattatgtta     4094

tcatcctccc ttttttgtac aatatgttgt ttacctgaaa ggaaggtttc tattcgttgg     4154

ttgtggacct ggacaaagtc caagtctgtg gaacttaaaa ccttgaaggt ctgtcatagg     4214

actctggaca atctcacacc ttagctattc ccagggaacc ccagggggca actgacattg     4274

ctccaagatg ttctcctgat gtagcttgag atataaagga aaggccctgc acaggtggct     4334

gtttcttgtc tgttatgtca gaggaacagt cctgttcaga aaggggctct tctgagcaga     4394

aatggctaat aaactttgtg ctgatctgga aaaaaaaaaa aaaaaaaaaa aaaaaaa        4451


<210>  322
<211>  851
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Ala Gln Trp Glu Met Leu Gln Asn Leu Asp Ser Pro Phe Gln Asp 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser His Ser Leu Leu Pro Val Asp Ile Arg 
            20                  25                  30          


Gln Tyr Leu Ala Val Trp Ile Glu Asp Gln Asn Trp Gln Glu Ala Ala 
        35                  40                  45              


Leu Gly Ser Asp Asp Ser Lys Ala Thr Met Leu Phe Phe His Phe Leu 
    50                  55                  60                  


Asp Gln Leu Asn Tyr Glu Cys Gly Arg Cys Ser Gln Asp Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Leu Gln His Asn Leu Arg Lys Phe Cys Arg Asp Ile Gln Pro 
                85                  90                  95      


Phe Ser Gln Asp Pro Thr Gln Leu Ala Glu Met Ile Phe Asn Leu Leu 
            100                 105                 110         


Leu Glu Glu Lys Arg Ile Leu Ile Gln Ala Gln Arg Ala Gln Leu Glu 
        115                 120                 125             


Gln Gly Glu Pro Val Leu Glu Thr Pro Val Glu Ser Gln Gln His Glu 
    130                 135                 140                 


Ile Glu Ser Arg Ile Leu Asp Leu Arg Ala Met Met Glu Lys Leu Val 
145                 150                 155                 160 


Lys Ser Ile Ser Gln Leu Lys Asp Gln Gln Asp Val Phe Cys Phe Arg 
                165                 170                 175     


Tyr Lys Ile Gln Ala Lys Gly Lys Thr Pro Ser Leu Asp Pro His Gln 
            180                 185                 190         


Thr Lys Glu Gln Lys Ile Leu Gln Glu Thr Leu Asn Glu Leu Asp Lys 
        195                 200                 205             


Arg Arg Lys Glu Val Leu Asp Ala Ser Lys Ala Leu Leu Gly Arg Leu 
    210                 215                 220                 


Thr Thr Leu Ile Glu Leu Leu Leu Pro Lys Leu Glu Glu Trp Lys Ala 
225                 230                 235                 240 


Gln Gln Gln Lys Ala Cys Ile Arg Ala Pro Ile Asp His Gly Leu Glu 
                245                 250                 255     


Gln Leu Glu Thr Trp Phe Thr Ala Gly Ala Lys Leu Leu Phe His Leu 
            260                 265                 270         


Arg Gln Leu Leu Lys Glu Leu Lys Gly Leu Ser Cys Leu Val Ser Tyr 
        275                 280                 285             


Gln Asp Asp Pro Leu Thr Lys Gly Val Asp Leu Arg Asn Ala Gln Val 
    290                 295                 300                 


Thr Glu Leu Leu Gln Arg Leu Leu His Arg Ala Phe Val Val Glu Thr 
305                 310                 315                 320 


Gln Pro Cys Met Pro Gln Thr Pro His Arg Pro Leu Ile Leu Lys Thr 
                325                 330                 335     


Gly Ser Lys Phe Thr Val Arg Thr Arg Leu Leu Val Arg Leu Gln Glu 
            340                 345                 350         


Gly Asn Glu Ser Leu Thr Val Glu Val Ser Ile Asp Arg Asn Pro Pro 
        355                 360                 365             


Gln Leu Gln Gly Phe Arg Lys Phe Asn Ile Leu Thr Ser Asn Gln Lys 
    370                 375                 380                 


Thr Leu Thr Pro Glu Lys Gly Gln Ser Gln Gly Leu Ile Trp Asp Phe 
385                 390                 395                 400 


Gly Tyr Leu Thr Leu Val Glu Gln Arg Ser Gly Gly Ser Gly Lys Gly 
                405                 410                 415     


Ser Asn Lys Gly Pro Leu Gly Val Thr Glu Glu Leu His Ile Ile Ser 
            420                 425                 430         


Phe Thr Val Lys Tyr Thr Tyr Gln Gly Leu Lys Gln Glu Leu Lys Thr 
        435                 440                 445             


Asp Thr Leu Pro Val Val Ile Ile Ser Asn Met Asn Gln Leu Ser Ile 
    450                 455                 460                 


Ala Trp Ala Ser Val Leu Trp Phe Asn Leu Leu Ser Pro Asn Leu Gln 
465                 470                 475                 480 


Asn Gln Gln Phe Phe Ser Asn Pro Pro Lys Ala Pro Trp Ser Leu Leu 
                485                 490                 495     


Gly Pro Ala Leu Ser Trp Gln Phe Ser Ser Tyr Val Gly Arg Gly Leu 
            500                 505                 510         


Asn Ser Asp Gln Leu Ser Met Leu Arg Asn Lys Leu Phe Gly Gln Asn 
        515                 520                 525             


Cys Arg Thr Glu Asp Pro Leu Leu Ser Trp Ala Asp Phe Thr Lys Arg 
    530                 535                 540                 


Glu Ser Pro Pro Gly Lys Leu Pro Phe Trp Thr Trp Leu Asp Lys Ile 
545                 550                 555                 560 


Leu Glu Leu Val His Asp His Leu Lys Asp Leu Trp Asn Asp Gly Arg 
                565                 570                 575     


Ile Met Gly Phe Val Ser Arg Ser Gln Glu Arg Arg Leu Leu Lys Lys 
            580                 585                 590         


Thr Met Ser Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Glu Gly 
        595                 600                 605             


Gly Ile Thr Cys Ser Trp Val Glu His Gln Asp Asp Asp Lys Val Leu 
    610                 615                 620                 


Ile Tyr Ser Val Gln Pro Tyr Thr Lys Glu Val Leu Gln Ser Leu Pro 
625                 630                 635                 640 


Leu Thr Glu Ile Ile Arg His Tyr Gln Leu Leu Thr Glu Glu Asn Ile 
                645                 650                 655     


Pro Glu Asn Pro Leu Arg Phe Leu Tyr Pro Arg Ile Pro Arg Asp Glu 
            660                 665                 670         


Ala Phe Gly Cys Tyr Tyr Gln Glu Lys Val Asn Leu Gln Glu Arg Arg 
        675                 680                 685             


Lys Tyr Leu Lys His Arg Leu Ile Val Val Ser Asn Arg Gln Val Asp 
    690                 695                 700                 


Glu Leu Gln Gln Pro Leu Glu Leu Lys Pro Glu Pro Glu Leu Glu Ser 
705                 710                 715                 720 


Leu Glu Leu Glu Leu Gly Leu Val Pro Glu Pro Glu Leu Ser Leu Asp 
                725                 730                 735     


Leu Glu Pro Leu Leu Lys Ala Gly Leu Asp Leu Gly Pro Glu Leu Glu 
            740                 745                 750         


Ser Val Leu Glu Ser Thr Leu Glu Pro Val Ile Glu Pro Thr Leu Cys 
        755                 760                 765             


Met Val Ser Gln Thr Val Pro Glu Pro Asp Gln Gly Pro Val Ser Gln 
    770                 775                 780                 


Pro Val Pro Glu Pro Asp Leu Pro Cys Asp Leu Arg His Leu Asn Thr 
785                 790                 795                 800 


Glu Pro Met Glu Ile Phe Arg Asn Cys Val Lys Ile Glu Glu Ile Met 
                805                 810                 815     


Pro Asn Gly Asp Pro Leu Leu Ala Gly Gln Asn Thr Val Asp Glu Val 
            820                 825                 830         


Tyr Val Ser Arg Pro Ser His Phe Tyr Thr Asp Gly Pro Leu Met Pro 
        835                 840                 845             


Ser Asp Phe 
    850     


<210>  323
<211>  2466
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (241)..(1860)

<400>  323
atgttttacg gaagccgata gtccttgctc agcggcaccc cgtccttccg gctctcggct       60

ttgccacaaa gcttcccgaa gacgcggccg ctacccggag acgcggtcgc cacccagaag      120

cgctctcccg ggaagccccg ctcgtgggac cgcgccacct gcgccgcctc tgcggcccgc      180

agcccgacgg gcgccgccat gttggggtcc tagcgaggga cgcgtaggtg tcttcataag      240

atg ccg ggg cag cgg cgc gcg ctt tcc ccc aag atg gcg tcc atg cgg        288
Met Pro Gly Gln Arg Arg Ala Leu Ser Pro Lys Met Ala Ser Met Arg           
1               5                   10                  15                

gag agc gac acg ggc ctg tgg ctg cac aac aag ctg ggg gcc acg gac        336
Glu Ser Asp Thr Gly Leu Trp Leu His Asn Lys Leu Gly Ala Thr Asp           
            20                  25                  30                    

gag ctg tgg gcg ccg ccc agc atc gcg tcc ctg ctc acg gcc gcg gtc        384
Glu Leu Trp Ala Pro Pro Ser Ile Ala Ser Leu Leu Thr Ala Ala Val           
        35                  40                  45                        

atc gac aac atc cgt ctc tgc ttc cat ggc ctc tcg tcg gca gtg aag        432
Ile Asp Asn Ile Arg Leu Cys Phe His Gly Leu Ser Ser Ala Val Lys           
    50                  55                  60                            

ctc aag ttg cta ctc ggg acg ctg cac ctc ccg cgc cgc acg gtg gac        480
Leu Lys Leu Leu Leu Gly Thr Leu His Leu Pro Arg Arg Thr Val Asp           
65                  70                  75                  80            

gag atg aag ggc gcc cta atg gag atc atc cag ctc gcc agc ctc gac        528
Glu Met Lys Gly Ala Leu Met Glu Ile Ile Gln Leu Ala Ser Leu Asp           
                85                  90                  95                

tcg gac ccc tgg gtg ctc atg gtc gcc gac atc ttg aag tcc ttt ccg        576
Ser Asp Pro Trp Val Leu Met Val Ala Asp Ile Leu Lys Ser Phe Pro           
            100                 105                 110                   

gac aca ggc tcg ctt aac ctg gag ctg gag gag cag aat ccc aac gtt        624
Asp Thr Gly Ser Leu Asn Leu Glu Leu Glu Glu Gln Asn Pro Asn Val           
        115                 120                 125                       

cag gat att ttg gga gaa ctt aga gaa aag gtg ggt gag tgt gaa gcg        672
Gln Asp Ile Leu Gly Glu Leu Arg Glu Lys Val Gly Glu Cys Glu Ala           
    130                 135                 140                           

tct gcc atg ctg cca ctg gag tgc cag tac ttg aac aaa aac gcc ctg        720
Ser Ala Met Leu Pro Leu Glu Cys Gln Tyr Leu Asn Lys Asn Ala Leu           
145                 150                 155                 160           

acg acc ctc gcg gga ccc ctc act ccc ccg gtg aag cat ttt cag tta        768
Thr Thr Leu Ala Gly Pro Leu Thr Pro Pro Val Lys His Phe Gln Leu           
                165                 170                 175               

aag cgg aaa ccc aag agc gcc acg ctg cgg gcg gag ctg ctg cag aag        816
Lys Arg Lys Pro Lys Ser Ala Thr Leu Arg Ala Glu Leu Leu Gln Lys           
            180                 185                 190                   

tcc acg gag acc gcc cag cag ttg aag cgg agc gcc ggg gtg ccc ttc        864
Ser Thr Glu Thr Ala Gln Gln Leu Lys Arg Ser Ala Gly Val Pro Phe           
        195                 200                 205                       

cac gcc aag ggc cgg ggg ctg ctg cgg aag atg gac acc acc acc cca        912
His Ala Lys Gly Arg Gly Leu Leu Arg Lys Met Asp Thr Thr Thr Pro           
    210                 215                 220                           

ctc aaa ggc atc ccg aag cag gcg ccc ttc aga agc ccc acg gcg ccc        960
Leu Lys Gly Ile Pro Lys Gln Ala Pro Phe Arg Ser Pro Thr Ala Pro           
225                 230                 235                 240           

agc gtc ttc agc ccc aca ggg aac cgg acc ccc atc ccg cct tcc agg       1008
Ser Val Phe Ser Pro Thr Gly Asn Arg Thr Pro Ile Pro Pro Ser Arg           
                245                 250                 255               

acg ctg ctg cgg aag gaa cga ggt gtg aag ctg ctg gac atc tct gag       1056
Thr Leu Leu Arg Lys Glu Arg Gly Val Lys Leu Leu Asp Ile Ser Glu           
            260                 265                 270                   

ctg gat atg gtt ggc gct ggc cga gag gcg aag cgg aga agg aag act       1104
Leu Asp Met Val Gly Ala Gly Arg Glu Ala Lys Arg Arg Arg Lys Thr           
        275                 280                 285                       

ctc gat gcg gag gtg gtg gag aag ccg gcc aag gag gaa acg gtg gtg       1152
Leu Asp Ala Glu Val Val Glu Lys Pro Ala Lys Glu Glu Thr Val Val           
    290                 295                 300                           

gag aac gcc acc ccg gac tac gca gcc ggc ctg gtg tcc acg cag aaa       1200
Glu Asn Ala Thr Pro Asp Tyr Ala Ala Gly Leu Val Ser Thr Gln Lys           
305                 310                 315                 320           

ctt ggg tcc ctg aac aat gag cct gcg ctg ccc tcc acg agc tac ctt       1248
Leu Gly Ser Leu Asn Asn Glu Pro Ala Leu Pro Ser Thr Ser Tyr Leu           
                325                 330                 335               

ccc tcc acg ccc agc gtg gtt ccc gcc tcc tcc tac atc ccc agc tcc       1296
Pro Ser Thr Pro Ser Val Val Pro Ala Ser Ser Tyr Ile Pro Ser Ser           
            340                 345                 350                   

gag acg ccc cca gcc cca tct tcc cgg gaa gcc agc cgc cca cca gag       1344
Glu Thr Pro Pro Ala Pro Ser Ser Arg Glu Ala Ser Arg Pro Pro Glu           
        355                 360                 365                       

gag ccc agc gcc ccg agc ccc acg ttg cca gcg cag ttc aag cag cgg       1392
Glu Pro Ser Ala Pro Ser Pro Thr Leu Pro Ala Gln Phe Lys Gln Arg           
    370                 375                 380                           

gcg ccc atg tac aac agc ggc ctg agc cct gcc aca ccc acg cct gcg       1440
Ala Pro Met Tyr Asn Ser Gly Leu Ser Pro Ala Thr Pro Thr Pro Ala           
385                 390                 395                 400           

gcg ccc acc tcg cct ctg aca ccc acc aca cct ccg gct gtc gcc cct       1488
Ala Pro Thr Ser Pro Leu Thr Pro Thr Thr Pro Pro Ala Val Ala Pro           
                405                 410                 415               

acc act cag aca ccc ccg gtt gcc atg gtg gcc ccg cag acc cag gcc       1536
Thr Thr Gln Thr Pro Pro Val Ala Met Val Ala Pro Gln Thr Gln Ala           
            420                 425                 430                   

cct gct cag cag cag cct aag aag aac ctg tcc ctc acg aga gag cag       1584
Pro Ala Gln Gln Gln Pro Lys Lys Asn Leu Ser Leu Thr Arg Glu Gln           
        435                 440                 445                       

atg ttc gct gcc cag gag atg ttc aag acg gcc aac aaa gtc acg cgg       1632
Met Phe Ala Ala Gln Glu Met Phe Lys Thr Ala Asn Lys Val Thr Arg           
    450                 455                 460                           

ccc gag aag gcc ctc atc ctg ggc ttc atg gcc ggc tcc cga gag aac       1680
Pro Glu Lys Ala Leu Ile Leu Gly Phe Met Ala Gly Ser Arg Glu Asn           
465                 470                 475                 480           

ccg tgc cag gag cag ggg gac gtg atc cag atc aag ctg agc gag cac       1728
Pro Cys Gln Glu Gln Gly Asp Val Ile Gln Ile Lys Leu Ser Glu His           
                485                 490                 495               

acg gag gac ctg ccc aag gcg gac ggc cag ggt agc aca acc atg ctg       1776
Thr Glu Asp Leu Pro Lys Ala Asp Gly Gln Gly Ser Thr Thr Met Leu           
            500                 505                 510                   

gtg gac aca gtg ttt gag atg aac tat gcc acg ggc cag tgg acg cgc       1824
Val Asp Thr Val Phe Glu Met Asn Tyr Ala Thr Gly Gln Trp Thr Arg           
        515                 520                 525                       

ttc aag aag tac aag ccc atg acc aat gtg tcc tag aaccacctgc            1870
Phe Lys Lys Tyr Lys Pro Met Thr Asn Val Ser                               
    530                 535                                               

ctcacagctg gccgtcactt gtgggggtcc acgggacgat ggctttgcca gcttaaagta     1930

accggatggc ggacacctgg cccccgaggt cccccggccg ccgccctgct gctgacccag     1990

cctgttttaa gttctggatg catttctctg gggtatttgg ggcttatttt taaaatttta     2050

atatgggttc ttttttgtgt gatttaagac actttttgga ctcaacgtta catttttgaa     2110

tgtagtaagt aaattaacca aaaaagttac aacttcctaa ttttagtgac agctctgcct     2170

gttagactct tactttttaa aatcttttct attttccctc gctggggcag tgccctccta     2230

cccccagggt tgaggggacc aaggtggcac ggtggtactg ggggtgcggc agggacaccc     2290

gaccacacca gagcgtggga gacggtgggc cttgtcccct gcctgtgcct gcctgggagt     2350

tttgtattca tcttttgtat agttgtggac atttaagaca gtctttgggt acctattttc     2410

attgtaaaac tatctgaacc attaaagtcg agcttttcta aagaaagcca ccaaaa         2466


<210>  324
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Pro Gly Gln Arg Arg Ala Leu Ser Pro Lys Met Ala Ser Met Arg 
1               5                   10                  15      


Glu Ser Asp Thr Gly Leu Trp Leu His Asn Lys Leu Gly Ala Thr Asp 
            20                  25                  30          


Glu Leu Trp Ala Pro Pro Ser Ile Ala Ser Leu Leu Thr Ala Ala Val 
        35                  40                  45              


Ile Asp Asn Ile Arg Leu Cys Phe His Gly Leu Ser Ser Ala Val Lys 
    50                  55                  60                  


Leu Lys Leu Leu Leu Gly Thr Leu His Leu Pro Arg Arg Thr Val Asp 
65                  70                  75                  80  


Glu Met Lys Gly Ala Leu Met Glu Ile Ile Gln Leu Ala Ser Leu Asp 
                85                  90                  95      


Ser Asp Pro Trp Val Leu Met Val Ala Asp Ile Leu Lys Ser Phe Pro 
            100                 105                 110         


Asp Thr Gly Ser Leu Asn Leu Glu Leu Glu Glu Gln Asn Pro Asn Val 
        115                 120                 125             


Gln Asp Ile Leu Gly Glu Leu Arg Glu Lys Val Gly Glu Cys Glu Ala 
    130                 135                 140                 


Ser Ala Met Leu Pro Leu Glu Cys Gln Tyr Leu Asn Lys Asn Ala Leu 
145                 150                 155                 160 


Thr Thr Leu Ala Gly Pro Leu Thr Pro Pro Val Lys His Phe Gln Leu 
                165                 170                 175     


Lys Arg Lys Pro Lys Ser Ala Thr Leu Arg Ala Glu Leu Leu Gln Lys 
            180                 185                 190         


Ser Thr Glu Thr Ala Gln Gln Leu Lys Arg Ser Ala Gly Val Pro Phe 
        195                 200                 205             


His Ala Lys Gly Arg Gly Leu Leu Arg Lys Met Asp Thr Thr Thr Pro 
    210                 215                 220                 


Leu Lys Gly Ile Pro Lys Gln Ala Pro Phe Arg Ser Pro Thr Ala Pro 
225                 230                 235                 240 


Ser Val Phe Ser Pro Thr Gly Asn Arg Thr Pro Ile Pro Pro Ser Arg 
                245                 250                 255     


Thr Leu Leu Arg Lys Glu Arg Gly Val Lys Leu Leu Asp Ile Ser Glu 
            260                 265                 270         


Leu Asp Met Val Gly Ala Gly Arg Glu Ala Lys Arg Arg Arg Lys Thr 
        275                 280                 285             


Leu Asp Ala Glu Val Val Glu Lys Pro Ala Lys Glu Glu Thr Val Val 
    290                 295                 300                 


Glu Asn Ala Thr Pro Asp Tyr Ala Ala Gly Leu Val Ser Thr Gln Lys 
305                 310                 315                 320 


Leu Gly Ser Leu Asn Asn Glu Pro Ala Leu Pro Ser Thr Ser Tyr Leu 
                325                 330                 335     


Pro Ser Thr Pro Ser Val Val Pro Ala Ser Ser Tyr Ile Pro Ser Ser 
            340                 345                 350         


Glu Thr Pro Pro Ala Pro Ser Ser Arg Glu Ala Ser Arg Pro Pro Glu 
        355                 360                 365             


Glu Pro Ser Ala Pro Ser Pro Thr Leu Pro Ala Gln Phe Lys Gln Arg 
    370                 375                 380                 


Ala Pro Met Tyr Asn Ser Gly Leu Ser Pro Ala Thr Pro Thr Pro Ala 
385                 390                 395                 400 


Ala Pro Thr Ser Pro Leu Thr Pro Thr Thr Pro Pro Ala Val Ala Pro 
                405                 410                 415     


Thr Thr Gln Thr Pro Pro Val Ala Met Val Ala Pro Gln Thr Gln Ala 
            420                 425                 430         


Pro Ala Gln Gln Gln Pro Lys Lys Asn Leu Ser Leu Thr Arg Glu Gln 
        435                 440                 445             


Met Phe Ala Ala Gln Glu Met Phe Lys Thr Ala Asn Lys Val Thr Arg 
    450                 455                 460                 


Pro Glu Lys Ala Leu Ile Leu Gly Phe Met Ala Gly Ser Arg Glu Asn 
465                 470                 475                 480 


Pro Cys Gln Glu Gln Gly Asp Val Ile Gln Ile Lys Leu Ser Glu His 
                485                 490                 495     


Thr Glu Asp Leu Pro Lys Ala Asp Gly Gln Gly Ser Thr Thr Met Leu 
            500                 505                 510         


Val Asp Thr Val Phe Glu Met Asn Tyr Ala Thr Gly Gln Trp Thr Arg 
        515                 520                 525             


Phe Lys Lys Tyr Lys Pro Met Thr Asn Val Ser 
    530                 535                 


<210>  325
<211>  3861
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (44)..(2260)

<400>  325
cgcctggccg gcgggctgag gcgtacgggt cgcacgcagc gcc atg cga ggc ccc         55
                                                Met Arg Gly Pro           
                                                1                         

cct gcc tgg ccg ctg cgg ctg ctc gag cca ccg agc cct gcc gag cca        103
Pro Ala Trp Pro Leu Arg Leu Leu Glu Pro Pro Ser Pro Ala Glu Pro           
5                   10                  15                  20            

ggt cgg ctc ctg ccg gta gcc tgc gtg tgg gcc gcg gcc agc cgc gtt        151
Gly Arg Leu Leu Pro Val Ala Cys Val Trp Ala Ala Ala Ser Arg Val           
                25                  30                  35                

ccc ggg tcc cta tcg ccg ttc act ggc ctg agg ccg gcg cgg cta tgg        199
Pro Gly Ser Leu Ser Pro Phe Thr Gly Leu Arg Pro Ala Arg Leu Trp           
            40                  45                  50                    

ggc gcg ggg ccc gcg ctg ctc tgg ggc gtt gga gcc gcg cgc cgc tgg        247
Gly Ala Gly Pro Ala Leu Leu Trp Gly Val Gly Ala Ala Arg Arg Trp           
        55                  60                  65                        

agg agc ggc tgc cgg ggc ggg ggt ccg ggc gcc tcg cgg ggc gtc ctg        295
Arg Ser Gly Cys Arg Gly Gly Gly Pro Gly Ala Ser Arg Gly Val Leu           
    70                  75                  80                            

ggc ctc gcg cgg ctc ctg ggg ctg tgg gct cgc ggc ccc ggc agc tgc        343
Gly Leu Ala Arg Leu Leu Gly Leu Trp Ala Arg Gly Pro Gly Ser Cys           
85                  90                  95                  100           

agg tgc ggg gct ttt gcc ggg cca ggc gct cct cgg ctc ccg cgc gcc        391
Arg Cys Gly Ala Phe Ala Gly Pro Gly Ala Pro Arg Leu Pro Arg Ala           
                105                 110                 115               

cgg ttc ccg ggc ggt ccc gca gcc gct gcc tgg gca ggg gac gag gcc        439
Arg Phe Pro Gly Gly Pro Ala Ala Ala Ala Trp Ala Gly Asp Glu Ala           
            120                 125                 130                   

tgg cgg cgc ggg ccg gcg gcg cct ccc ggg gac aag ggg cgg ctg cgc        487
Trp Arg Arg Gly Pro Ala Ala Pro Pro Gly Asp Lys Gly Arg Leu Arg           
        135                 140                 145                       

ccc gca gcg gcc gga ctc ccg gag gcc cgg aag ctc ctg ggg ctg gcg        535
Pro Ala Ala Ala Gly Leu Pro Glu Ala Arg Lys Leu Leu Gly Leu Ala           
    150                 155                 160                           

tac cct gag cgc cgg agg ctg gca gct gcg gtt gga ttt ctc acg atg        583
Tyr Pro Glu Arg Arg Arg Leu Ala Ala Ala Val Gly Phe Leu Thr Met           
165                 170                 175                 180           

tcc agt gtt atc tcc atg tct gcc cct ttc ttc ctg ggg aag atc att        631
Ser Ser Val Ile Ser Met Ser Ala Pro Phe Phe Leu Gly Lys Ile Ile           
                185                 190                 195               

gat gtc atc tat acc aac ccc act gtg gac tac agc gac aac ctg acc        679
Asp Val Ile Tyr Thr Asn Pro Thr Val Asp Tyr Ser Asp Asn Leu Thr           
            200                 205                 210                   

cgc ctc tgc cta ggg ctc agt gcc gtg ttt ctg tgt ggt gct gcc gcc        727
Arg Leu Cys Leu Gly Leu Ser Ala Val Phe Leu Cys Gly Ala Ala Ala           
        215                 220                 225                       

aat gcc att cgt gtc tac ctc atg caa act tca ggt cag cgc att gtg        775
Asn Ala Ile Arg Val Tyr Leu Met Gln Thr Ser Gly Gln Arg Ile Val           
    230                 235                 240                           

aat agg ctg aga act tca tta ttc tcc tcc att ctg agg cag gag gtt        823
Asn Arg Leu Arg Thr Ser Leu Phe Ser Ser Ile Leu Arg Gln Glu Val           
245                 250                 255                 260           

gct ttc ttt gac aag act cgc aca gga gaa ttg att aac cgc ctc tca        871
Ala Phe Phe Asp Lys Thr Arg Thr Gly Glu Leu Ile Asn Arg Leu Ser           
                265                 270                 275               

tca gac act gca ctc ctg ggg cgc tca gtg act gaa aac ctc tca gat        919
Ser Asp Thr Ala Leu Leu Gly Arg Ser Val Thr Glu Asn Leu Ser Asp           
            280                 285                 290                   

ggg ctc agg gcc ggg gcc cag gct tcc gta ggc atc agt atg atg ttt        967
Gly Leu Arg Ala Gly Ala Gln Ala Ser Val Gly Ile Ser Met Met Phe           
        295                 300                 305                       

ttt gtc tca cct aat ctg gcc acc ttt gtt ttg agc gtg gtg cct cca       1015
Phe Val Ser Pro Asn Leu Ala Thr Phe Val Leu Ser Val Val Pro Pro           
    310                 315                 320                           

gtg tca atc att gct gta att tat ggg cga tat cta cgg aaa ctg acc       1063
Val Ser Ile Ile Ala Val Ile Tyr Gly Arg Tyr Leu Arg Lys Leu Thr           
325                 330                 335                 340           

aaa gtc act cag gat tcc ctg gca caa gcc act cag cta gct gag gaa       1111
Lys Val Thr Gln Asp Ser Leu Ala Gln Ala Thr Gln Leu Ala Glu Glu           
                345                 350                 355               

cgt att gga aat gta aga act gtt cga gct ttt ggg aaa gaa atg act       1159
Arg Ile Gly Asn Val Arg Thr Val Arg Ala Phe Gly Lys Glu Met Thr           
            360                 365                 370                   

gaa atc gag aaa tat gcc agc aaa gtg gac cat gta atg cag tta gca       1207
Glu Ile Glu Lys Tyr Ala Ser Lys Val Asp His Val Met Gln Leu Ala           
        375                 380                 385                       

agg aaa gag gca ttc gcc cgg gct ggt ttc ttt gga gca act ggg ctc       1255
Arg Lys Glu Ala Phe Ala Arg Ala Gly Phe Phe Gly Ala Thr Gly Leu           
    390                 395                 400                           

tcc gga aac ctg atc gtg ctt tct gtc ctg tac aaa gga ggg ctg ctg       1303
Ser Gly Asn Leu Ile Val Leu Ser Val Leu Tyr Lys Gly Gly Leu Leu           
405                 410                 415                 420           

atg ggc agt gcc cac atg acc gtg ggt gaa ctc tct tcc ttc cta atg       1351
Met Gly Ser Ala His Met Thr Val Gly Glu Leu Ser Ser Phe Leu Met           
                425                 430                 435               

tat gct ttc tgg gtt gga ata agc att gga ggt ctg agc tct ttc tac       1399
Tyr Ala Phe Trp Val Gly Ile Ser Ile Gly Gly Leu Ser Ser Phe Tyr           
            440                 445                 450                   

tcg gag ctg atg aaa gga ctg ggt gca ggg ggg cgc ctc tgg gag ctc       1447
Ser Glu Leu Met Lys Gly Leu Gly Ala Gly Gly Arg Leu Trp Glu Leu           
        455                 460                 465                       

ctg gag aga gag ccc aag ctg cct ttt aac gag ggg gtc atc tta aat       1495
Leu Glu Arg Glu Pro Lys Leu Pro Phe Asn Glu Gly Val Ile Leu Asn           
    470                 475                 480                           

gag aaa agc ttc cag ggt gct ttg gag ttt aag aac gtg cat ttt gcc       1543
Glu Lys Ser Phe Gln Gly Ala Leu Glu Phe Lys Asn Val His Phe Ala           
485                 490                 495                 500           

tat cca gct cgc cca gag gtg ccc ata ttt cag gat ttc agc ctt tcc       1591
Tyr Pro Ala Arg Pro Glu Val Pro Ile Phe Gln Asp Phe Ser Leu Ser           
                505                 510                 515               

att ccg tca gga tct gtc acg gca ctg gtt ggc cca agt ggt tct ggc       1639
Ile Pro Ser Gly Ser Val Thr Ala Leu Val Gly Pro Ser Gly Ser Gly           
            520                 525                 530                   

aaa tca aca gtg ctt tca ctc ctg ctg agg ttg tac gac cct gct tct       1687
Lys Ser Thr Val Leu Ser Leu Leu Leu Arg Leu Tyr Asp Pro Ala Ser           
        535                 540                 545                       

gga act att agt ctt gat ggc cat gac atc cgt cag cta aac cca gtg       1735
Gly Thr Ile Ser Leu Asp Gly His Asp Ile Arg Gln Leu Asn Pro Val           
    550                 555                 560                           

tgg ctg aga tcc aaa att ggg aca gtg agt cag gaa ccc att ttg ttt       1783
Trp Leu Arg Ser Lys Ile Gly Thr Val Ser Gln Glu Pro Ile Leu Phe           
565                 570                 575                 580           

tct tgc tct att gct gag aac att gct tat ggt gct gat gac cct tcc       1831
Ser Cys Ser Ile Ala Glu Asn Ile Ala Tyr Gly Ala Asp Asp Pro Ser           
                585                 590                 595               

tct gtg acc gct gag gaa atc cag aga gtg gct gaa gtg gcc aat gca       1879
Ser Val Thr Ala Glu Glu Ile Gln Arg Val Ala Glu Val Ala Asn Ala           
            600                 605                 610                   

gtg gcc ttc atc cgg aat ttc ccc caa ggg ttc aac act gtg gtt gga       1927
Val Ala Phe Ile Arg Asn Phe Pro Gln Gly Phe Asn Thr Val Val Gly           
        615                 620                 625                       

gaa aag ggt gtt ctc ctc tca ggt ggg cag aaa cag cgg att gcg att       1975
Glu Lys Gly Val Leu Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile           
    630                 635                 640                           

gcc cgt gct ctg cta aag aat ccc aaa att ctt ctc cta gat gaa gca       2023
Ala Arg Ala Leu Leu Lys Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala           
645                 650                 655                 660           

acc agt gcg ctg gat gcc gaa aat gag tac ctt gtt caa gaa gct cta       2071
Thr Ser Ala Leu Asp Ala Glu Asn Glu Tyr Leu Val Gln Glu Ala Leu           
                665                 670                 675               

gat cga ctg atg gat gga aga acg gtg tta gtt att gcc cat cgt ctg       2119
Asp Arg Leu Met Asp Gly Arg Thr Val Leu Val Ile Ala His Arg Leu           
            680                 685                 690                   

tcc acc att aag aat gct aat atg gtt gct gtt ctt gac caa gga aaa       2167
Ser Thr Ile Lys Asn Ala Asn Met Val Ala Val Leu Asp Gln Gly Lys           
        695                 700                 705                       

att act gaa tat gga aaa cat gaa gag ctg ctt tca aaa cca aat ggg       2215
Ile Thr Glu Tyr Gly Lys His Glu Glu Leu Leu Ser Lys Pro Asn Gly           
    710                 715                 720                           

ata tac aga aaa cta atg aac aaa caa agt ttt att tca gca taa           2260
Ile Tyr Arg Lys Leu Met Asn Lys Gln Ser Phe Ile Ser Ala                   
725                 730                 735                               

ggaagcaatt actggtaaac aatatgagac tttaatgcaa aacagtgttg cagaaaaaaa     2320

actcagagac tatgaaatac ataaaccata tatcaagtta tttgaaaaat acctattttt     2380

ttccaaagtg tgtaaaagat tgttttgaaa cgtacctgtt ctcaagatct ttttattcag     2440

agttttaata attgtaactt tttaaatgtc tatagcactg aagttatttt caggttttgt     2500

attttctttt cttgtggaat attttaatta atatagcatg gcacctcatt ttcttttgcc     2560

tgctgttaaa gattgaagct attgtcaaat gacaacttta aaaaggcaat tataaataaa     2620

aagcctgatt attttaggcc agtttaccaa tcactgtgta attcttctgg tagtattcta     2680

cctactttta agtctaattt tacagataga ataatggaaa ttgaaaattt aaccctttat     2740

tccgataatc tcatgaagca aacctaacta tttaacatca gctggaaaga agggaacatt     2800

tatattgccc atctcctgtg tcttcaaagg tgtgagagct gaggaatatg tgttcctatg     2860

ggaactatgt ttgaatatgt gcagttttca acattttggc acatgaaagc ctgacaagtt     2920

tttaaaaggg cagaagcttt attttttgaa caggaaaaca tgttttttaa attcacatgt     2980

ttgtatgagt acttttgcga agcaaggcat gaactgctag gtattattaa gaatgaatga     3040

tttttgcatt taagttgttt gaaggcatgt attttgaaaa atatctgtta caaatttata     3100

atttcaagac aaattgaatc ttattttata atacttttgg aatttcatta ataaggctaa     3160

aatttgagga atataactaa ttttcagcct taagacattt aagtttggaa gtccttgcta     3220

ttcaacagaa taacaagaaa acttcagaat gtatcactct cctgaaaaga agatattaat     3280

aagccctttt atttatggtt atagttttat ttatagtctc aaaattccta aagcaatgct     3340

acaaccattg aatttgccat attttgtatc agtgctgtta atttgctgtt gcctcaagaa     3400

aaagtgcttt ttctccatgg atgaggctag accctaagaa gtaattaagt caatgtaaat     3460

caaatggaag ttttcccatg aactaagcat ttattagttc cctgattaga ctggaagaag     3520

aaaccactat ttcatgaaaa gcatggaata ttatatttta ttgttcataa ttaatgaata     3580

aaattgatat gaatgaatat agtgttcttt gaattagtaa acagtacatc tgtgacaatc     3640

atttttaaca agctctactt gtgttcttta taaagtgtga ttttcagaaa gcaaacaaca     3700

caattacaag gttgaatctg aggaaaataa tccttgtgcc atagaagtat ttacgaaatt     3760

gcatttcatt gttatgtttt attttctgat acatgatgtt caattttatc tttaggtaat     3820

attttatatc atagattaaa atttatagtg aactttaaaa a                         3861


<210>  326
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  326

Met Arg Gly Pro Pro Ala Trp Pro Leu Arg Leu Leu Glu Pro Pro Ser 
1               5                   10                  15      


Pro Ala Glu Pro Gly Arg Leu Leu Pro Val Ala Cys Val Trp Ala Ala 
            20                  25                  30          


Ala Ser Arg Val Pro Gly Ser Leu Ser Pro Phe Thr Gly Leu Arg Pro 
        35                  40                  45              


Ala Arg Leu Trp Gly Ala Gly Pro Ala Leu Leu Trp Gly Val Gly Ala 
    50                  55                  60                  


Ala Arg Arg Trp Arg Ser Gly Cys Arg Gly Gly Gly Pro Gly Ala Ser 
65                  70                  75                  80  


Arg Gly Val Leu Gly Leu Ala Arg Leu Leu Gly Leu Trp Ala Arg Gly 
                85                  90                  95      


Pro Gly Ser Cys Arg Cys Gly Ala Phe Ala Gly Pro Gly Ala Pro Arg 
            100                 105                 110         


Leu Pro Arg Ala Arg Phe Pro Gly Gly Pro Ala Ala Ala Ala Trp Ala 
        115                 120                 125             


Gly Asp Glu Ala Trp Arg Arg Gly Pro Ala Ala Pro Pro Gly Asp Lys 
    130                 135                 140                 


Gly Arg Leu Arg Pro Ala Ala Ala Gly Leu Pro Glu Ala Arg Lys Leu 
145                 150                 155                 160 


Leu Gly Leu Ala Tyr Pro Glu Arg Arg Arg Leu Ala Ala Ala Val Gly 
                165                 170                 175     


Phe Leu Thr Met Ser Ser Val Ile Ser Met Ser Ala Pro Phe Phe Leu 
            180                 185                 190         


Gly Lys Ile Ile Asp Val Ile Tyr Thr Asn Pro Thr Val Asp Tyr Ser 
        195                 200                 205             


Asp Asn Leu Thr Arg Leu Cys Leu Gly Leu Ser Ala Val Phe Leu Cys 
    210                 215                 220                 


Gly Ala Ala Ala Asn Ala Ile Arg Val Tyr Leu Met Gln Thr Ser Gly 
225                 230                 235                 240 


Gln Arg Ile Val Asn Arg Leu Arg Thr Ser Leu Phe Ser Ser Ile Leu 
                245                 250                 255     


Arg Gln Glu Val Ala Phe Phe Asp Lys Thr Arg Thr Gly Glu Leu Ile 
            260                 265                 270         


Asn Arg Leu Ser Ser Asp Thr Ala Leu Leu Gly Arg Ser Val Thr Glu 
        275                 280                 285             


Asn Leu Ser Asp Gly Leu Arg Ala Gly Ala Gln Ala Ser Val Gly Ile 
    290                 295                 300                 


Ser Met Met Phe Phe Val Ser Pro Asn Leu Ala Thr Phe Val Leu Ser 
305                 310                 315                 320 


Val Val Pro Pro Val Ser Ile Ile Ala Val Ile Tyr Gly Arg Tyr Leu 
                325                 330                 335     


Arg Lys Leu Thr Lys Val Thr Gln Asp Ser Leu Ala Gln Ala Thr Gln 
            340                 345                 350         


Leu Ala Glu Glu Arg Ile Gly Asn Val Arg Thr Val Arg Ala Phe Gly 
        355                 360                 365             


Lys Glu Met Thr Glu Ile Glu Lys Tyr Ala Ser Lys Val Asp His Val 
    370                 375                 380                 


Met Gln Leu Ala Arg Lys Glu Ala Phe Ala Arg Ala Gly Phe Phe Gly 
385                 390                 395                 400 


Ala Thr Gly Leu Ser Gly Asn Leu Ile Val Leu Ser Val Leu Tyr Lys 
                405                 410                 415     


Gly Gly Leu Leu Met Gly Ser Ala His Met Thr Val Gly Glu Leu Ser 
            420                 425                 430         


Ser Phe Leu Met Tyr Ala Phe Trp Val Gly Ile Ser Ile Gly Gly Leu 
        435                 440                 445             


Ser Ser Phe Tyr Ser Glu Leu Met Lys Gly Leu Gly Ala Gly Gly Arg 
    450                 455                 460                 


Leu Trp Glu Leu Leu Glu Arg Glu Pro Lys Leu Pro Phe Asn Glu Gly 
465                 470                 475                 480 


Val Ile Leu Asn Glu Lys Ser Phe Gln Gly Ala Leu Glu Phe Lys Asn 
                485                 490                 495     


Val His Phe Ala Tyr Pro Ala Arg Pro Glu Val Pro Ile Phe Gln Asp 
            500                 505                 510         


Phe Ser Leu Ser Ile Pro Ser Gly Ser Val Thr Ala Leu Val Gly Pro 
        515                 520                 525             


Ser Gly Ser Gly Lys Ser Thr Val Leu Ser Leu Leu Leu Arg Leu Tyr 
    530                 535                 540                 


Asp Pro Ala Ser Gly Thr Ile Ser Leu Asp Gly His Asp Ile Arg Gln 
545                 550                 555                 560 


Leu Asn Pro Val Trp Leu Arg Ser Lys Ile Gly Thr Val Ser Gln Glu 
                565                 570                 575     


Pro Ile Leu Phe Ser Cys Ser Ile Ala Glu Asn Ile Ala Tyr Gly Ala 
            580                 585                 590         


Asp Asp Pro Ser Ser Val Thr Ala Glu Glu Ile Gln Arg Val Ala Glu 
        595                 600                 605             


Val Ala Asn Ala Val Ala Phe Ile Arg Asn Phe Pro Gln Gly Phe Asn 
    610                 615                 620                 


Thr Val Val Gly Glu Lys Gly Val Leu Leu Ser Gly Gly Gln Lys Gln 
625                 630                 635                 640 


Arg Ile Ala Ile Ala Arg Ala Leu Leu Lys Asn Pro Lys Ile Leu Leu 
                645                 650                 655     


Leu Asp Glu Ala Thr Ser Ala Leu Asp Ala Glu Asn Glu Tyr Leu Val 
            660                 665                 670         


Gln Glu Ala Leu Asp Arg Leu Met Asp Gly Arg Thr Val Leu Val Ile 
        675                 680                 685             


Ala His Arg Leu Ser Thr Ile Lys Asn Ala Asn Met Val Ala Val Leu 
    690                 695                 700                 


Asp Gln Gly Lys Ile Thr Glu Tyr Gly Lys His Glu Glu Leu Leu Ser 
705                 710                 715                 720 


Lys Pro Asn Gly Ile Tyr Arg Lys Leu Met Asn Lys Gln Ser Phe Ile 
                725                 730                 735     


Ser Ala 
        


<210>  327
<211>  2961
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (134)..(499)

<400>  327
agtgcgcagg cagtgctcgc ggcggcggcg acggcggcgg gaggttcggt tgtcgcccgt       60

tggccgcgcg gcgccgcgct cggcggccgc cattgcagct tgttttcact tgctttttaa      120

agacagaaag ctc atg gtg caa att gtt att tcc agt gcg agg gct gga         169
               Met Val Gln Ile Val Ile Ser Ser Ala Arg Ala Gly            
               1               5                   10                     

ggc ctg gca gaa tgg gtg ctg atg gag cta cag ggg gag atc gag gct        217
Gly Leu Ala Glu Trp Val Leu Met Glu Leu Gln Gly Glu Ile Glu Ala           
        15                  20                  25                        

cgc tac agc act gga tta gct gga aac ctc ctg gga gac cta cat tac        265
Arg Tyr Ser Thr Gly Leu Ala Gly Asn Leu Leu Gly Asp Leu His Tyr           
    30                  35                  40                            

acc act gag gga atc cct gtg ctg atc gtg ggg cat cat atc ctg tat        313
Thr Thr Glu Gly Ile Pro Val Leu Ile Val Gly His His Ile Leu Tyr           
45                  50                  55                  60            

ggg aaa atc atc cac ctg gag aaa cct ttt gca gtc ctt gtc aaa cac        361
Gly Lys Ile Ile His Leu Glu Lys Pro Phe Ala Val Leu Val Lys His           
                65                  70                  75                

act cct ggg gat cag gac tgt gat gag ctt ggc cgc gag act ggc acc        409
Thr Pro Gly Asp Gln Asp Cys Asp Glu Leu Gly Arg Glu Thr Gly Thr           
            80                  85                  90                    

cgg tac ctg gtg aca gca ctc atc aaa gac aag atc ctt ttc aaa acc        457
Arg Tyr Leu Val Thr Ala Leu Ile Lys Asp Lys Ile Leu Phe Lys Thr           
        95                  100                 105                       

cgc ccc aag ccc att atc acc agc gtc ccc aag aaa gta tga                499
Arg Pro Lys Pro Ile Ile Thr Ser Val Pro Lys Lys Val                       
    110                 115                 120                           

aagaacctcg gattttccct agagagcggc caactccttg gactcgtgct ccgctgccac      559

ctcgaggacg gctcgacggt tccctgggac cacagggggg tcctgttctg aacacaggcc      619

acccactggg tgtgaactcg gatcccttcc ttatggcggc cggttctctt ggtggaaatc      679

tgaccccatt tccaaggaac ccatctcctt ttccagcttc atcaggctca ttggcttcaa      739

atccagcacc tttcccggct ggtgctcgtg acccaagtat ggcttctttt ccaagaggga      799

tgaatcccac tggcacaggt gcagtttctt tcccaaggcc tggtggcctc ttggggccag      859

gcccaggccc aggccccacc ctaaacccta ggacaggggc tctgccaggc ccagggcctc      919

tgtctaaccc caggttaggg ggtctcccag gaccaggtcc tatgtccaac ccaagggcag      979

gtggtctcct gggagcaggt cctgacccca gaggtggtgg tcccatgggc cctggatctg     1039

gacctaacct gagagccggt gttctgttaa cctctgggaa tggtcctccc aatcctaggc     1099

cagttggcct gggcccagga ccaaacccca atctgagatc aggcttttta gggacaaacc     1159

ctgcccccag gtcaggtgtg tttccaggcc caggccttgg gcccaaccca agaccaagtg     1219

gcctgggccc aggccctaat ctagatgcca gagcaggtgg cctcttgggc acaggatctg     1279

gtcttaactt aagaatggct ggacctcaag gcctcgatct tgcccccatt ctaagagcag     1339

caggtctttt aggagcaaat tcagcttctt tctcacaggc ttctggaaac atgggcacaa     1399

gcccatcctc catggcaaga gtacctggcc ccatgggccc aaactcgggt cctagctctc     1459

ggggaattgg ccttccaggg ccaaatccat ctcccatgtc aagggctcct ggccccatag     1519

gccctaattc agctcatttc tcaaggccag ttggccccat gggggtaaat gccaatccct     1579

ttcccagggg agcaggttca tctgcctttt ctcagtcttc tggcacattg gcatcaaacc     1639

cagctacctt ccaaaggtcc gctggcctcc agggctcaaa tccaaccatt ttcccaagag     1699

cctctgggcc acttggcccc aacccagcta acttcccaag ggccactggc ctgcagggtc     1759

caagtccaac taccttccca aggtctactg gcccattagg ccctggtcaa gttactttcc     1819

ccaggccagc tgccgggcat ctgggccctt ctccagctgg ccctgtgggt atcaacccag     1879

ctcctttcac aaggccaact gggaccctgg gtctcaaccc agcttccttt ccaaggatga     1939

atggccctgc aggcaagagt ttcgtcccat ttcctagagt ggggagcctc cctggcacaa     1999

acccagctgc tttccccaga ccagggggtc caatggctgc aatgtaccca aatggaatgt     2059

tgccccctta aacaccattt tccctccagg accaccttgg tttctaggca ctgtggttct     2119

tggcaggggc tgtcttaggt aaaagggtag ttgtggagct acagtctgaa gaacatagct     2179

tgggctcaag ttcaaatgag ccatcttttt cctttgcgtt tttcttgact gaaggtgaga     2239

tgttatttgt ggcatgtgaa ctgtggcagg tgggaataat cctgcccttg agagaaagga     2299

tctccagcct cccagaagcc tgctgtgctt tcgtcccaca gctttctgcc cattgtttct     2359

tactagtttc ttgaattgtt cttgtggact tttcctcagg gatacattgg cctgcaggtc     2419

ccagttcaca tgtagtcccc tgctcaccat tggagaatca gctcactgct ctctagaaac     2479

gtggcgttgg tgaacggacc atgcttccgt agctctgacc tgggcagctt ggacctggtc     2539

atcctctact gccatacctt tccctggggg cttgaacaca gaacagggag atggacaacc     2599

acttcaaaga aagacccacc gaatgcagtt tctgcttgac tgactgggcc tgcagctccc     2659

ttctcctggg acttagaggt ggccagattt aaggcccctc tactcatcca actccctctt     2719

cactggtact cccaatcaat caaagaacct caaaatttaa actgatgtgg atgggaatat     2779

gggaattagg gtgggggtgg gggatgaagg gaagaaatca ctgtgctttg ttcggcctgg     2839

tgtgcaagga tggttggtgg ttttcctgca ttgtatcttt tcttactgtt tctttaataa     2899

atgggatgag agggcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2959

aa                                                                    2961


<210>  328
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Val Gln Ile Val Ile Ser Ser Ala Arg Ala Gly Gly Leu Ala Glu 
1               5                   10                  15      


Trp Val Leu Met Glu Leu Gln Gly Glu Ile Glu Ala Arg Tyr Ser Thr 
            20                  25                  30          


Gly Leu Ala Gly Asn Leu Leu Gly Asp Leu His Tyr Thr Thr Glu Gly 
        35                  40                  45              


Ile Pro Val Leu Ile Val Gly His His Ile Leu Tyr Gly Lys Ile Ile 
    50                  55                  60                  


His Leu Glu Lys Pro Phe Ala Val Leu Val Lys His Thr Pro Gly Asp 
65                  70                  75                  80  


Gln Asp Cys Asp Glu Leu Gly Arg Glu Thr Gly Thr Arg Tyr Leu Val 
                85                  90                  95      


Thr Ala Leu Ile Lys Asp Lys Ile Leu Phe Lys Thr Arg Pro Lys Pro 
            100                 105                 110         


Ile Ile Thr Ser Val Pro Lys Lys Val 
        115                 120     


<210>  329
<211>  4018
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (247)..(2496)

<400>  329
gttccgcccg ccgctcttcc agctgagact cggcagcggc ggtcggagcg gctgccacgc       60

cgcacctgcc cgcgaggggg cgcgccaggc ccaggccgca gccgactgcc gcgctctctg      120

tccccgccct ccgccatccc cggactgcgc tcacctgtct gggccgctgg cctgggaggc      180

gggggccggc gggagccaag ccgaggaaag ggcggagcgg ctctccgggc gcgtcatcgg      240

agcacc atg gcg gag cta gga gct ggc ggc gac ggc cac agg ggc ggc         288
       Met Ala Glu Leu Gly Ala Gly Gly Asp Gly His Arg Gly Gly            
       1               5                   10                             

gac ggc gca gtg cga agc gaa aca gca ccc gac agc tac aaa gtg caa        336
Asp Gly Ala Val Arg Ser Glu Thr Ala Pro Asp Ser Tyr Lys Val Gln           
15                  20                  25                  30            

gat aag aaa aat gcc tcc agc cgc cct gcc tct gca att tca gga caa        384
Asp Lys Lys Asn Ala Ser Ser Arg Pro Ala Ser Ala Ile Ser Gly Gln           
                35                  40                  45                

aat aac aac cac tca gga aat aaa cca gac cct ccg cct gtg tta cgt        432
Asn Asn Asn His Ser Gly Asn Lys Pro Asp Pro Pro Pro Val Leu Arg           
            50                  55                  60                    

gtt gat gac cgg cag cgg ctg gcc cgg gag cga cgt gag gaa cgg gag        480
Val Asp Asp Arg Gln Arg Leu Ala Arg Glu Arg Arg Glu Glu Arg Glu           
        65                  70                  75                        

aaa cag cta gct gca aga gaa ata gtg tgg tta gaa aga gaa gag cga        528
Lys Gln Leu Ala Ala Arg Glu Ile Val Trp Leu Glu Arg Glu Glu Arg           
    80                  85                  90                            

gcc agg cag cac tac gag aag cac ctg gaa gag cgg aag aag agg ttg        576
Ala Arg Gln His Tyr Glu Lys His Leu Glu Glu Arg Lys Lys Arg Leu           
95                  100                 105                 110           

gag gag cag agg cag aag gag gag cgg agg agg gct gct gtg gag gag        624
Glu Glu Gln Arg Gln Lys Glu Glu Arg Arg Arg Ala Ala Val Glu Glu           
                115                 120                 125               

aag cgg agg cag aga ctt gag gag gac aaa gaa cgc cac gaa gct gtt        672
Lys Arg Arg Gln Arg Leu Glu Glu Asp Lys Glu Arg His Glu Ala Val           
            130                 135                 140                   

gta cgg cgc aca atg gaa agg agc cag aag cca aaa cag aag cat aac        720
Val Arg Arg Thr Met Glu Arg Ser Gln Lys Pro Lys Gln Lys His Asn           
        145                 150                 155                       

cgt tgg tcg tgg gga ggc tct ctc cat ggg agc cct agc atc cac agt        768
Arg Trp Ser Trp Gly Gly Ser Leu His Gly Ser Pro Ser Ile His Ser           
    160                 165                 170                           

gca gat cca gac agg cgg tca gtt tcc acc atg aat ctt tcg aaa tat        816
Ala Asp Pro Asp Arg Arg Ser Val Ser Thr Met Asn Leu Ser Lys Tyr           
175                 180                 185                 190           

gtt gat ccc gtc att agc aag cgg ctc tcc tct tca tct gca act tta        864
Val Asp Pro Val Ile Ser Lys Arg Leu Ser Ser Ser Ser Ala Thr Leu           
                195                 200                 205               

cta aat tct cca gat aga gct cgc cgc ctg cag ctc agc cca tgg gag        912
Leu Asn Ser Pro Asp Arg Ala Arg Arg Leu Gln Leu Ser Pro Trp Glu           
            210                 215                 220                   

agc agc gtt gtt aac aga ctc ctg acg ccc aca cat tcg ttc ctg gcc        960
Ser Ser Val Val Asn Arg Leu Leu Thr Pro Thr His Ser Phe Leu Ala           
        225                 230                 235                       

aga agt aaa agc aca gct gcc ttg tct gga gaa gca gca tct tgc agc       1008
Arg Ser Lys Ser Thr Ala Ala Leu Ser Gly Glu Ala Ala Ser Cys Ser           
    240                 245                 250                           

ccc atc atc atg ccc tac aaa gct gca cac tct aga aat tcg atg gat       1056
Pro Ile Ile Met Pro Tyr Lys Ala Ala His Ser Arg Asn Ser Met Asp           
255                 260                 265                 270           

cga cca aaa ctc ttt gta aca cca cct gag ggc tct tct cgc agg agg       1104
Arg Pro Lys Leu Phe Val Thr Pro Pro Glu Gly Ser Ser Arg Arg Arg           
                275                 280                 285               

atc att cat ggc aca gcg agc tat aaa aaa gaa aga gag aga gaa aat       1152
Ile Ile His Gly Thr Ala Ser Tyr Lys Lys Glu Arg Glu Arg Glu Asn           
            290                 295                 300                   

gta ctc ttc ctc aca tct ggc acc cga agg gct gta tct cca tct aat       1200
Val Leu Phe Leu Thr Ser Gly Thr Arg Arg Ala Val Ser Pro Ser Asn           
        305                 310                 315                       

ccc aaa gca aga caa cca gct cgc tcc cga ctt tgg ctt ccg tcc aag       1248
Pro Lys Ala Arg Gln Pro Ala Arg Ser Arg Leu Trp Leu Pro Ser Lys           
    320                 325                 330                           

tct ctt cct cat ttg cct ggc aca ccc aga ccg aca tcc tcc ttg cca       1296
Ser Leu Pro His Leu Pro Gly Thr Pro Arg Pro Thr Ser Ser Leu Pro           
335                 340                 345                 350           

ccc ggc tca gtc aaa gct gct cct gct cag gtc cgg ccc cca tcc ccc       1344
Pro Gly Ser Val Lys Ala Ala Pro Ala Gln Val Arg Pro Pro Ser Pro           
                355                 360                 365               

ggc aac atc cgc cct gtc aag agg gaa gtc aaa gtg gag cct gag aag       1392
Gly Asn Ile Arg Pro Val Lys Arg Glu Val Lys Val Glu Pro Glu Lys           
            370                 375                 380                   

aaa gat cct gag aag gaa cct cag aaa gtt gcc aat gag ccc tca cta       1440
Lys Asp Pro Glu Lys Glu Pro Gln Lys Val Ala Asn Glu Pro Ser Leu           
        385                 390                 395                       

aag ggc aga gca cct tta gtg aag gta gaa gaa gcc aca gtt gaa gag       1488
Lys Gly Arg Ala Pro Leu Val Lys Val Glu Glu Ala Thr Val Glu Glu           
    400                 405                 410                           

cgg aca cct gct gaa cca gaa gtt ggc cct gct gct cca gcc atg gcc       1536
Arg Thr Pro Ala Glu Pro Glu Val Gly Pro Ala Ala Pro Ala Met Ala           
415                 420                 425                 430           

cca gct cca gcc tcg gcc cca gct cca gcc tcg gcc cca gct cca gcc       1584
Pro Ala Pro Ala Ser Ala Pro Ala Pro Ala Ser Ala Pro Ala Pro Ala           
                435                 440                 445               

ccg gtc ccc acc cca gcc atg gtc tca gcc ccg tca tcc act gtg aat       1632
Pro Val Pro Thr Pro Ala Met Val Ser Ala Pro Ser Ser Thr Val Asn           
            450                 455                 460                   

gcc agt gct tct gtt aag act tct gca ggc acc acc gac cca gag gag       1680
Ala Ser Ala Ser Val Lys Thr Ser Ala Gly Thr Thr Asp Pro Glu Glu           
        465                 470                 475                       

gcc aca agg ctt cta gct gag aag agg cgg ctg gcc cga gag cag aga       1728
Ala Thr Arg Leu Leu Ala Glu Lys Arg Arg Leu Ala Arg Glu Gln Arg           
    480                 485                 490                           

gaa aag gaa gaa agg gag agg agg gag cag gaa gag ctt gaa aga caa       1776
Glu Lys Glu Glu Arg Glu Arg Arg Glu Gln Glu Glu Leu Glu Arg Gln           
495                 500                 505                 510           

aag aga gag gaa ttg gct caa cgt gtg gct gaa gag agg acg act cgc       1824
Lys Arg Glu Glu Leu Ala Gln Arg Val Ala Glu Glu Arg Thr Thr Arg           
                515                 520                 525               

cgt gag gag gag tcg cgc agg ctg gaa gcc gag cag gcc cgg gag aag       1872
Arg Glu Glu Glu Ser Arg Arg Leu Glu Ala Glu Gln Ala Arg Glu Lys           
            530                 535                 540                   

gag gag cag ctg cag cgg cag gcg gag gag cgg gcg ctg cgc gag cgg       1920
Glu Glu Gln Leu Gln Arg Gln Ala Glu Glu Arg Ala Leu Arg Glu Arg           
        545                 550                 555                       

gag gag gca gag cgc gcc cag agg cag aaa gaa gaa gaa gct cgc gtt       1968
Glu Glu Ala Glu Arg Ala Gln Arg Gln Lys Glu Glu Glu Ala Arg Val           
    560                 565                 570                           

cgt gaa gaa gca gag agg gtc cgg cag gaa cga gag aag cat ttc cag       2016
Arg Glu Glu Ala Glu Arg Val Arg Gln Glu Arg Glu Lys His Phe Gln           
575                 580                 585                 590           

aga gaa gag caa gag cgc ctg gag aga aag aag cga ctt gag gag att       2064
Arg Glu Glu Gln Glu Arg Leu Glu Arg Lys Lys Arg Leu Glu Glu Ile           
                595                 600                 605               

atg aaa aga acc agg aga aca gaa gct aca gat aag aaa acc agt gat       2112
Met Lys Arg Thr Arg Arg Thr Glu Ala Thr Asp Lys Lys Thr Ser Asp           
            610                 615                 620                   

cag aga aac ggt gat ata gcc aag gga gct ctc act gga gga aca gag       2160
Gln Arg Asn Gly Asp Ile Ala Lys Gly Ala Leu Thr Gly Gly Thr Glu           
        625                 630                 635                       

gtg tct gca ctt cca tgt aca aca aac gct ccg gga aat gga aag cca       2208
Val Ser Ala Leu Pro Cys Thr Thr Asn Ala Pro Gly Asn Gly Lys Pro           
    640                 645                 650                           

gtt ggc agc cca cat gtg gtt acc tca cac cag tca aaa gtg aca gtg       2256
Val Gly Ser Pro His Val Val Thr Ser His Gln Ser Lys Val Thr Val           
655                 660                 665                 670           

gag agc act ccc gat ttg gaa aaa caa cca aat gaa aat ggt gta tct       2304
Glu Ser Thr Pro Asp Leu Glu Lys Gln Pro Asn Glu Asn Gly Val Ser           
                675                 680                 685               

gtt cag aat gaa aat ttt gaa gaa att ata aac tta ccc att gga tct       2352
Val Gln Asn Glu Asn Phe Glu Glu Ile Ile Asn Leu Pro Ile Gly Ser           
            690                 695                 700                   

aaa cca tcc aga tta gat gtc acc aac agt gag agc cca gaa att cct       2400
Lys Pro Ser Arg Leu Asp Val Thr Asn Ser Glu Ser Pro Glu Ile Pro           
        705                 710                 715                       

ttg aat cca att ttg gcc ttt gat gat gaa ggg aca ctt ggg ccc ctg       2448
Leu Asn Pro Ile Leu Ala Phe Asp Asp Glu Gly Thr Leu Gly Pro Leu           
    720                 725                 730                           

cct cag gta gat ggt gtt cag aca cag cag act gca gaa gtt ata tga       2496
Pro Gln Val Asp Gly Val Gln Thr Gln Gln Thr Ala Glu Val Ile               
735                 740                 745                               

gtgtttcttc tgaagaacca aagctgaaat ttaatgagaa tttctacaat taatggaatt     2556

cctttcctgc tataaaggag catcccctcc acccgttttc tagagttctt gaccatcatt     2616

ttgaaaagat ttattaaaac tagctaaaga caacagactg gatagctttt ctaataattt     2676

tcatcaatag gaaaaaagaa atacgtctca ttcttcaata ctttaaaatg gctttttcca     2736

gtgtgctcct tcttagcaat caatattttt ctgcattctt taaaagacaa gagaatttgg     2796

ttataaaaga aatgggctga ctaggcatga tttttttggt cttaaaagct taacatgtaa     2856

aattggcaaa aaaaattttt taccttttat aatacttgaa aaataagtac ctctttgttc     2916

tacaagtaga atgaatagga gaagagttta agcctgtttt tttaaaatat tattgcaaag     2976

agctctattt gtagaagcaa attataggca gattaccagg ttcttataaa tacagcttgt     3036

acatggacat tctgcaaacc cagctgtcac atttttcttg caactccttt tgcaaaagca     3096

gactaaaatg ttttaaaatg tgaaaaaaca ttattttttc aaagcaagaa aataatttac     3156

tgccctctta cataatgtat ttataaagtt tttccagata aactaatcaa ataaattaga     3216

ataatgtgac aacattacaa atttaatttg ttagctgcat tccttctgat gttaccacga     3276

tagaatgtta ctgatgattc agggctattt ctgaagtctg tatgttgctg ctgtccccag     3336

tgatggtgga cttatctttg ccttacctga tcacaaatta tgttggggaa aataaagatt     3396

taatatttct ttaaatagaa aaagaatttg gttttgctcg tttaagagca atgagaaaat     3456

gatggaatgt tgactgtgtt tggcacacag gacacggacc ttcatggaag tccttgctct     3516

gcgtggcatc tgtcagcttt tcacctttca ttcttattct tcacttttgc tgctgagcct     3576

agctgtacaa acttgcactt tcatttgcta atataaattc agttttattt taccatttta     3636

gagactacta atgattaaat gtagaaggag agggtgcaca tgtttttatg tggagtgttt     3696

aaaagataaa tttataccac tgtaatgtgc agcttttatt aaaagagaaa ttggttgaac     3756

tgctaggttg aatgagagac ttcatctatt ggactatttt ttttaatcca ggcatatggt     3816

ctttagtaat ggcttgtaat ttgtgaaaac attaatttgg gggttttccc tgttttcagt     3876

tgtccatgta cacatagtca ttatattaga aaagaaagct gttcaacaaa cttgtttaat     3936

ttgtttaaat caacatagca tgaaacacca aataaaatgt ttgacatagt tttaaaaaaa     3996

aaaaaaaaaa aaaaaaaaaa aa                                              4018


<210>  330
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Ala Glu Leu Gly Ala Gly Gly Asp Gly His Arg Gly Gly Asp Gly 
1               5                   10                  15      


Ala Val Arg Ser Glu Thr Ala Pro Asp Ser Tyr Lys Val Gln Asp Lys 
            20                  25                  30          


Lys Asn Ala Ser Ser Arg Pro Ala Ser Ala Ile Ser Gly Gln Asn Asn 
        35                  40                  45              


Asn His Ser Gly Asn Lys Pro Asp Pro Pro Pro Val Leu Arg Val Asp 
    50                  55                  60                  


Asp Arg Gln Arg Leu Ala Arg Glu Arg Arg Glu Glu Arg Glu Lys Gln 
65                  70                  75                  80  


Leu Ala Ala Arg Glu Ile Val Trp Leu Glu Arg Glu Glu Arg Ala Arg 
                85                  90                  95      


Gln His Tyr Glu Lys His Leu Glu Glu Arg Lys Lys Arg Leu Glu Glu 
            100                 105                 110         


Gln Arg Gln Lys Glu Glu Arg Arg Arg Ala Ala Val Glu Glu Lys Arg 
        115                 120                 125             


Arg Gln Arg Leu Glu Glu Asp Lys Glu Arg His Glu Ala Val Val Arg 
    130                 135                 140                 


Arg Thr Met Glu Arg Ser Gln Lys Pro Lys Gln Lys His Asn Arg Trp 
145                 150                 155                 160 


Ser Trp Gly Gly Ser Leu His Gly Ser Pro Ser Ile His Ser Ala Asp 
                165                 170                 175     


Pro Asp Arg Arg Ser Val Ser Thr Met Asn Leu Ser Lys Tyr Val Asp 
            180                 185                 190         


Pro Val Ile Ser Lys Arg Leu Ser Ser Ser Ser Ala Thr Leu Leu Asn 
        195                 200                 205             


Ser Pro Asp Arg Ala Arg Arg Leu Gln Leu Ser Pro Trp Glu Ser Ser 
    210                 215                 220                 


Val Val Asn Arg Leu Leu Thr Pro Thr His Ser Phe Leu Ala Arg Ser 
225                 230                 235                 240 


Lys Ser Thr Ala Ala Leu Ser Gly Glu Ala Ala Ser Cys Ser Pro Ile 
                245                 250                 255     


Ile Met Pro Tyr Lys Ala Ala His Ser Arg Asn Ser Met Asp Arg Pro 
            260                 265                 270         


Lys Leu Phe Val Thr Pro Pro Glu Gly Ser Ser Arg Arg Arg Ile Ile 
        275                 280                 285             


His Gly Thr Ala Ser Tyr Lys Lys Glu Arg Glu Arg Glu Asn Val Leu 
    290                 295                 300                 


Phe Leu Thr Ser Gly Thr Arg Arg Ala Val Ser Pro Ser Asn Pro Lys 
305                 310                 315                 320 


Ala Arg Gln Pro Ala Arg Ser Arg Leu Trp Leu Pro Ser Lys Ser Leu 
                325                 330                 335     


Pro His Leu Pro Gly Thr Pro Arg Pro Thr Ser Ser Leu Pro Pro Gly 
            340                 345                 350         


Ser Val Lys Ala Ala Pro Ala Gln Val Arg Pro Pro Ser Pro Gly Asn 
        355                 360                 365             


Ile Arg Pro Val Lys Arg Glu Val Lys Val Glu Pro Glu Lys Lys Asp 
    370                 375                 380                 


Pro Glu Lys Glu Pro Gln Lys Val Ala Asn Glu Pro Ser Leu Lys Gly 
385                 390                 395                 400 


Arg Ala Pro Leu Val Lys Val Glu Glu Ala Thr Val Glu Glu Arg Thr 
                405                 410                 415     


Pro Ala Glu Pro Glu Val Gly Pro Ala Ala Pro Ala Met Ala Pro Ala 
            420                 425                 430         


Pro Ala Ser Ala Pro Ala Pro Ala Ser Ala Pro Ala Pro Ala Pro Val 
        435                 440                 445             


Pro Thr Pro Ala Met Val Ser Ala Pro Ser Ser Thr Val Asn Ala Ser 
    450                 455                 460                 


Ala Ser Val Lys Thr Ser Ala Gly Thr Thr Asp Pro Glu Glu Ala Thr 
465                 470                 475                 480 


Arg Leu Leu Ala Glu Lys Arg Arg Leu Ala Arg Glu Gln Arg Glu Lys 
                485                 490                 495     


Glu Glu Arg Glu Arg Arg Glu Gln Glu Glu Leu Glu Arg Gln Lys Arg 
            500                 505                 510         


Glu Glu Leu Ala Gln Arg Val Ala Glu Glu Arg Thr Thr Arg Arg Glu 
        515                 520                 525             


Glu Glu Ser Arg Arg Leu Glu Ala Glu Gln Ala Arg Glu Lys Glu Glu 
    530                 535                 540                 


Gln Leu Gln Arg Gln Ala Glu Glu Arg Ala Leu Arg Glu Arg Glu Glu 
545                 550                 555                 560 


Ala Glu Arg Ala Gln Arg Gln Lys Glu Glu Glu Ala Arg Val Arg Glu 
                565                 570                 575     


Glu Ala Glu Arg Val Arg Gln Glu Arg Glu Lys His Phe Gln Arg Glu 
            580                 585                 590         


Glu Gln Glu Arg Leu Glu Arg Lys Lys Arg Leu Glu Glu Ile Met Lys 
        595                 600                 605             


Arg Thr Arg Arg Thr Glu Ala Thr Asp Lys Lys Thr Ser Asp Gln Arg 
    610                 615                 620                 


Asn Gly Asp Ile Ala Lys Gly Ala Leu Thr Gly Gly Thr Glu Val Ser 
625                 630                 635                 640 


Ala Leu Pro Cys Thr Thr Asn Ala Pro Gly Asn Gly Lys Pro Val Gly 
                645                 650                 655     


Ser Pro His Val Val Thr Ser His Gln Ser Lys Val Thr Val Glu Ser 
            660                 665                 670         


Thr Pro Asp Leu Glu Lys Gln Pro Asn Glu Asn Gly Val Ser Val Gln 
        675                 680                 685             


Asn Glu Asn Phe Glu Glu Ile Ile Asn Leu Pro Ile Gly Ser Lys Pro 
    690                 695                 700                 


Ser Arg Leu Asp Val Thr Asn Ser Glu Ser Pro Glu Ile Pro Leu Asn 
705                 710                 715                 720 


Pro Ile Leu Ala Phe Asp Asp Glu Gly Thr Leu Gly Pro Leu Pro Gln 
                725                 730                 735     


Val Asp Gly Val Gln Thr Gln Gln Thr Ala Glu Val Ile 
            740                 745                 


<210>  331
<211>  1262
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (244)..(864)

<400>  331
tgtgtcactt ccggcctccc tttagctgcc atcttgcgtc cccgcgtgtg tgcgcctaat       60

ctcaggtggt ccacccgaga ccccttgagc accaacccta gtcccccgcg cggcccctta      120

ttcgctccga caaggtacaa aaaggctctg gacggcggcg tggtaggagg acgggagcgg      180

gggcgggaag ttccctgaag gagcgagaca gggagggaca gggcagagga ggagaggaag      240

gcg atg cga cgg aca ggc gca ccc gct cag gct gac tct cgg ggg cga        288
    Met Arg Arg Thr Gly Ala Pro Ala Gln Ala Asp Ser Arg Gly Arg           
    1               5                   10                  15            

ggt cga gcc agg ggc ggc tgc cct ggg ggc gag gcg acg ctg tct caa        336
Gly Arg Ala Arg Gly Gly Cys Pro Gly Gly Glu Ala Thr Leu Ser Gln           
                20                  25                  30                

cct cca cct cgc ggc gga acc cga gga cag gag cct cag atg aaa gaa        384
Pro Pro Pro Arg Gly Gly Thr Arg Gly Gln Glu Pro Gln Met Lys Glu           
            35                  40                  45                    

aca atc atg aac cag gaa aaa ctc gcc aaa ctg cag gca caa gtg cgc        432
Thr Ile Met Asn Gln Glu Lys Leu Ala Lys Leu Gln Ala Gln Val Arg           
        50                  55                  60                        

att ggt ggg aaa gga act gct cgc aga aag aag aag gtg gtt cat aga        480
Ile Gly Gly Lys Gly Thr Ala Arg Arg Lys Lys Lys Val Val His Arg           
    65                  70                  75                            

aca gcc aca gca gat gac aaa aaa ctt cag ttc tcc tta aag aag tta        528
Thr Ala Thr Ala Asp Asp Lys Lys Leu Gln Phe Ser Leu Lys Lys Leu           
80                  85                  90                  95            

ggg gta aac aat atc tct ggt att gaa gag gtg aat atg ttt aca aac        576
Gly Val Asn Asn Ile Ser Gly Ile Glu Glu Val Asn Met Phe Thr Asn           
                100                 105                 110               

caa gga aca gtg atc cac ttt aac aac cct aaa gtt cag gca tct ctg        624
Gln Gly Thr Val Ile His Phe Asn Asn Pro Lys Val Gln Ala Ser Leu           
            115                 120                 125                   

gca gcg aac act ttc acc att aca ggc cat gct gag aca aag cag ctg        672
Ala Ala Asn Thr Phe Thr Ile Thr Gly His Ala Glu Thr Lys Gln Leu           
        130                 135                 140                       

aca gaa atg cta ccc agc atc tta aac cag ctt ggt gcg gat agt ctg        720
Thr Glu Met Leu Pro Ser Ile Leu Asn Gln Leu Gly Ala Asp Ser Leu           
    145                 150                 155                           

act agt tta agg aga ctg gcc gaa gct ctg ccc aaa caa tct gtg gat        768
Thr Ser Leu Arg Arg Leu Ala Glu Ala Leu Pro Lys Gln Ser Val Asp           
160                 165                 170                 175           

gga aaa gca cca ctt gct act gga gag gat gat gat gat gaa gtt cca        816
Gly Lys Ala Pro Leu Ala Thr Gly Glu Asp Asp Asp Asp Glu Val Pro           
                180                 185                 190               

gat ctt gtg gag aat ttt gat gag gct tcc aag aat gag gca aac tga        864
Asp Leu Val Glu Asn Phe Asp Glu Ala Ser Lys Asn Glu Ala Asn               
            195                 200                 205                   

attgagtcaa cttctgaaga taaaacctga agaagttact gggagctgct attttatatt      924

atgactgctt tttaagaaat ttttgtttat ggatctgata aaatctagat ctctaatatt      984

tttaagccca agccccttgg acactgcagc tcttttcagt ttttgcttat acacaattca     1044

ttctttgcag ctaattaagc cgaagaagcc tgggaatcaa gtttgaaaca aagattaata     1104

aagttctttg cctagtatac agttttattt ttttatttca ttgacaccga tctgtacaca     1164

gtaaaaaaaa ttgcttatag aaagctaatc atggcatgta atatggctga taacctttgg     1224

aatttgatta aagatttaaa atcacaaaaa aaaaaaaa                             1262


<210>  332
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  332

Met Arg Arg Thr Gly Ala Pro Ala Gln Ala Asp Ser Arg Gly Arg Gly 
1               5                   10                  15      


Arg Ala Arg Gly Gly Cys Pro Gly Gly Glu Ala Thr Leu Ser Gln Pro 
            20                  25                  30          


Pro Pro Arg Gly Gly Thr Arg Gly Gln Glu Pro Gln Met Lys Glu Thr 
        35                  40                  45              


Ile Met Asn Gln Glu Lys Leu Ala Lys Leu Gln Ala Gln Val Arg Ile 
    50                  55                  60                  


Gly Gly Lys Gly Thr Ala Arg Arg Lys Lys Lys Val Val His Arg Thr 
65                  70                  75                  80  


Ala Thr Ala Asp Asp Lys Lys Leu Gln Phe Ser Leu Lys Lys Leu Gly 
                85                  90                  95      


Val Asn Asn Ile Ser Gly Ile Glu Glu Val Asn Met Phe Thr Asn Gln 
            100                 105                 110         


Gly Thr Val Ile His Phe Asn Asn Pro Lys Val Gln Ala Ser Leu Ala 
        115                 120                 125             


Ala Asn Thr Phe Thr Ile Thr Gly His Ala Glu Thr Lys Gln Leu Thr 
    130                 135                 140                 


Glu Met Leu Pro Ser Ile Leu Asn Gln Leu Gly Ala Asp Ser Leu Thr 
145                 150                 155                 160 


Ser Leu Arg Arg Leu Ala Glu Ala Leu Pro Lys Gln Ser Val Asp Gly 
                165                 170                 175     


Lys Ala Pro Leu Ala Thr Gly Glu Asp Asp Asp Asp Glu Val Pro Asp 
            180                 185                 190         


Leu Val Glu Asn Phe Asp Glu Ala Ser Lys Asn Glu Ala Asn 
        195                 200                 205     


<210>  333
<211>  3172
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (65)..(2680)

<400>  333
gtcggttccc gattctggtc cccggccccc agcagcgcct gcccccttcc caccggggcc       60

cccc atg atg cca cca ccc ttc atg ccc cct cca ggg atc ccc cca ccc       109
     Met Met Pro Pro Pro Phe Met Pro Pro Pro Gly Ile Pro Pro Pro          
     1               5                   10                  15           

ttt cct ccg atg ggg cta ccc ccc atg agt cag aga cca cca gct atc        157
Phe Pro Pro Met Gly Leu Pro Pro Met Ser Gln Arg Pro Pro Ala Ile           
                20                  25                  30                

ccc ccc atg cca cct ggc atc ctg ccc cca atg ctt cca cca atg ggg        205
Pro Pro Met Pro Pro Gly Ile Leu Pro Pro Met Leu Pro Pro Met Gly           
            35                  40                  45                    

gcg cca cca cca ctc aca cag ata cca gga atg gta cct ccg atg atg        253
Ala Pro Pro Pro Leu Thr Gln Ile Pro Gly Met Val Pro Pro Met Met           
        50                  55                  60                        

cca gga atg ctg atg cca gcg gtg cct gtc acc gca gcg acg gct ccg        301
Pro Gly Met Leu Met Pro Ala Val Pro Val Thr Ala Ala Thr Ala Pro           
    65                  70                  75                            

ggt gcg gac acc gcc agc tct gct gtg gct ggg aca ggc cct ccg agg        349
Gly Ala Asp Thr Ala Ser Ser Ala Val Ala Gly Thr Gly Pro Pro Arg           
80                  85                  90                  95            

gcc cta tgg agt gag cat gtg gcc cca gat ggg cgc atc tac tac tac        397
Ala Leu Trp Ser Glu His Val Ala Pro Asp Gly Arg Ile Tyr Tyr Tyr           
                100                 105                 110               

aat gct gac gac aag cag tcc gtg tgg gag aag ccc agc gtg ctc aag        445
Asn Ala Asp Asp Lys Gln Ser Val Trp Glu Lys Pro Ser Val Leu Lys           
            115                 120                 125                   

tcc aag gca gag ctg ctc ctg tcc caa tgt ccc tgg aaa gag tac aag        493
Ser Lys Ala Glu Leu Leu Leu Ser Gln Cys Pro Trp Lys Glu Tyr Lys           
        130                 135                 140                       

tcg gac aca ggc aaa cct tat tac tat aac aac cag agt aaa gag tcc        541
Ser Asp Thr Gly Lys Pro Tyr Tyr Tyr Asn Asn Gln Ser Lys Glu Ser           
    145                 150                 155                           

cgc tgg acc cgg ccc aag gat ctg gat gac cta gag gtt cta gtc aaa        589
Arg Trp Thr Arg Pro Lys Asp Leu Asp Asp Leu Glu Val Leu Val Lys           
160                 165                 170                 175           

caa gag gct gca ggg aaa cag cag cag cag ctg cca cag aca ctt cag        637
Gln Glu Ala Ala Gly Lys Gln Gln Gln Gln Leu Pro Gln Thr Leu Gln           
                180                 185                 190               

cca cag cca cct cag cca cag cct gac ccc cca cct gtg cct cct ggc        685
Pro Gln Pro Pro Gln Pro Gln Pro Asp Pro Pro Pro Val Pro Pro Gly           
            195                 200                 205                   

ccc acc cca gtg ccc aca ggc ctc ctg gaa cct gag cca ggt ggg agt        733
Pro Thr Pro Val Pro Thr Gly Leu Leu Glu Pro Glu Pro Gly Gly Ser           
        210                 215                 220                       

gaa gat tgt gat gtg ttg gag gcc acc cag ccc ctg gaa cag ggg ttc        781
Glu Asp Cys Asp Val Leu Glu Ala Thr Gln Pro Leu Glu Gln Gly Phe           
    225                 230                 235                           

ctg cag cag ctg gag gag ggc ccc agc agt tct gga cag cat cag cca        829
Leu Gln Gln Leu Glu Glu Gly Pro Ser Ser Ser Gly Gln His Gln Pro           
240                 245                 250                 255           

cag cag gag gag gag gaa tca aag cca gaa cca gag agg tct ggc ctc        877
Gln Gln Glu Glu Glu Glu Ser Lys Pro Glu Pro Glu Arg Ser Gly Leu           
                260                 265                 270               

agt tgg agc aac cgg gag aag gca aag cag gca ttc aag gaa ctg ctg        925
Ser Trp Ser Asn Arg Glu Lys Ala Lys Gln Ala Phe Lys Glu Leu Leu           
            275                 280                 285                   

agg gac aag gct gtc ccc tcc aat gcc tca tgg gaa cag gcc atg aag        973
Arg Asp Lys Ala Val Pro Ser Asn Ala Ser Trp Glu Gln Ala Met Lys           
        290                 295                 300                       

atg gtg gtc acc gac ccc cgt tac agt gcc ttg cct aaa ctg agt gag       1021
Met Val Val Thr Asp Pro Arg Tyr Ser Ala Leu Pro Lys Leu Ser Glu           
    305                 310                 315                           

aaa aag cag gca ttc aat gcc tac aag gcg cag cgg gag aag gag gag       1069
Lys Lys Gln Ala Phe Asn Ala Tyr Lys Ala Gln Arg Glu Lys Glu Glu           
320                 325                 330                 335           

aag gag gag gcc cgg cta agg gcc aaa gag gcc aag cag acc ctg cag       1117
Lys Glu Glu Ala Arg Leu Arg Ala Lys Glu Ala Lys Gln Thr Leu Gln           
                340                 345                 350               

cat ttc ctg gag cag cat gaa cgc atg acc tcc acc acc cgc tac cgg       1165
His Phe Leu Glu Gln His Glu Arg Met Thr Ser Thr Thr Arg Tyr Arg           
            355                 360                 365                   

cgg gca gaa cag acc ttt ggg gag ctg gag gtc tgg gct gtg gtc cct       1213
Arg Ala Glu Gln Thr Phe Gly Glu Leu Glu Val Trp Ala Val Val Pro           
        370                 375                 380                       

gag agg gat cga aaa gag gtt tat gat gat gtc ctc ttc ttc ctg gcc       1261
Glu Arg Asp Arg Lys Glu Val Tyr Asp Asp Val Leu Phe Phe Leu Ala           
    385                 390                 395                           

aag aag gag aag gaa cag gcc aag cag ctc cgg cgc cgc aat atc cag       1309
Lys Lys Glu Lys Glu Gln Ala Lys Gln Leu Arg Arg Arg Asn Ile Gln           
400                 405                 410                 415           

gcc cta aag agc atc ctg gat ggg atg agt agt gtc aac ttc caa acc       1357
Ala Leu Lys Ser Ile Leu Asp Gly Met Ser Ser Val Asn Phe Gln Thr           
                420                 425                 430               

acg tgg tcc cag gcc cag cag tac ctc atg gat aac ccc agc ttt gct       1405
Thr Trp Ser Gln Ala Gln Gln Tyr Leu Met Asp Asn Pro Ser Phe Ala           
            435                 440                 445                   

cag gac cat cag ctg cag aac atg gac aag gaa gat gca ctg atc tgt       1453
Gln Asp His Gln Leu Gln Asn Met Asp Lys Glu Asp Ala Leu Ile Cys           
        450                 455                 460                       

ttt gag gag cac atc cga gct ttg gag agg gaa gag gag gag gaa cgg       1501
Phe Glu Glu His Ile Arg Ala Leu Glu Arg Glu Glu Glu Glu Glu Arg           
    465                 470                 475                           

gag cgg gcc cgg ctt cgg gag cga cgc caa caa cgc aag aat cgg gag       1549
Glu Arg Ala Arg Leu Arg Glu Arg Arg Gln Gln Arg Lys Asn Arg Glu           
480                 485                 490                 495           

gcc ttc cag acc ttc ctg gac gag ctg cat gag aca ggg cag ctg cac       1597
Ala Phe Gln Thr Phe Leu Asp Glu Leu His Glu Thr Gly Gln Leu His           
                500                 505                 510               

tct atg tcc acc tgg atg gag cta tat cca gca gtc agc act gat gtc       1645
Ser Met Ser Thr Trp Met Glu Leu Tyr Pro Ala Val Ser Thr Asp Val           
            515                 520                 525                   

cgc ttt gcc aac atg ctg ggc cag ccg ggc tcc acc cct ctg gac tta       1693
Arg Phe Ala Asn Met Leu Gly Gln Pro Gly Ser Thr Pro Leu Asp Leu           
        530                 535                 540                       

ttc aag ttc tat gtg gag gag ttg aag gca cga ttc cat gat gaa aag       1741
Phe Lys Phe Tyr Val Glu Glu Leu Lys Ala Arg Phe His Asp Glu Lys           
    545                 550                 555                           

aag atc att aag gac atc ctt aag gac cgg ggc ttc tgc gtg gag gtg       1789
Lys Ile Ile Lys Asp Ile Leu Lys Asp Arg Gly Phe Cys Val Glu Val           
560                 565                 570                 575           

aac acg gcc ttt gag gac ttc gcc cac gtc ata agc ttt gac aag agg       1837
Asn Thr Ala Phe Glu Asp Phe Ala His Val Ile Ser Phe Asp Lys Arg           
                580                 585                 590               

gct gcc gca ctg gac gca ggc aac atc aag ctg acc ttc aat agt ctg       1885
Ala Ala Ala Leu Asp Ala Gly Asn Ile Lys Leu Thr Phe Asn Ser Leu           
            595                 600                 605                   

ctg gag aaa gca gag gca cgg gag agg gag cgg gag aag gag gag gca       1933
Leu Glu Lys Ala Glu Ala Arg Glu Arg Glu Arg Glu Lys Glu Glu Ala           
        610                 615                 620                       

cgc agg atg cgg cgc agg gaa gct gcc ttt cga agc atg ctg agg cag       1981
Arg Arg Met Arg Arg Arg Glu Ala Ala Phe Arg Ser Met Leu Arg Gln           
    625                 630                 635                           

gct gtg cct gct ctg gag cta ggc act gcc tgg gaa gag gtc cgt gag       2029
Ala Val Pro Ala Leu Glu Leu Gly Thr Ala Trp Glu Glu Val Arg Glu           
640                 645                 650                 655           

cgt ttt gtg tgt gac tca gcc ttt gag cag atc acc ctg gag tcg gag       2077
Arg Phe Val Cys Asp Ser Ala Phe Glu Gln Ile Thr Leu Glu Ser Glu           
                660                 665                 670               

cgg atc cgg ctc ttc cgg gag ttc cta cag gtg ctg gag cag act gaa       2125
Arg Ile Arg Leu Phe Arg Glu Phe Leu Gln Val Leu Glu Gln Thr Glu           
            675                 680                 685                   

tgc cag cac ctc cac acc aaa ggc cga aag cat ggc agg aaa ggc aag       2173
Cys Gln His Leu His Thr Lys Gly Arg Lys His Gly Arg Lys Gly Lys           
        690                 695                 700                       

aag cac cat cac aag cgt tcc cac tca ccc tca ggc tct gag tca gaa       2221
Lys His His His Lys Arg Ser His Ser Pro Ser Gly Ser Glu Ser Glu           
    705                 710                 715                           

gaa gag gag ctg ccc cca cca tct ctc cgg ccc ccc aag cgg agg agg       2269
Glu Glu Glu Leu Pro Pro Pro Ser Leu Arg Pro Pro Lys Arg Arg Arg           
720                 725                 730                 735           

cgg aac ccc tca gag tca ggc tct gag ccc tct tcc tca ctt gat tca       2317
Arg Asn Pro Ser Glu Ser Gly Ser Glu Pro Ser Ser Ser Leu Asp Ser           
                740                 745                 750               

gtt gaa agt ggg ggt gct gcc ctt gga gga cgg ggc tcc cct tcc tcc       2365
Val Glu Ser Gly Gly Ala Ala Leu Gly Gly Arg Gly Ser Pro Ser Ser           
            755                 760                 765                   

cat ctt ctt gga gca gat cat ggc ctt cgg aaa gcc aag aaa cca aaa       2413
His Leu Leu Gly Ala Asp His Gly Leu Arg Lys Ala Lys Lys Pro Lys           
        770                 775                 780                       

aag aaa act aag aag aga aga cac aag tcg aat agt cct gag agt gag       2461
Lys Lys Thr Lys Lys Arg Arg His Lys Ser Asn Ser Pro Glu Ser Glu           
    785                 790                 795                           

aca gac cct gag gag aaa gct ggc aag gag agc gat gag aaa gaa caa       2509
Thr Asp Pro Glu Glu Lys Ala Gly Lys Glu Ser Asp Glu Lys Glu Gln           
800                 805                 810                 815           

gaa cag gac aag gac agg gag ctc caa cag gca gag ctc cct aac cgt       2557
Glu Gln Asp Lys Asp Arg Glu Leu Gln Gln Ala Glu Leu Pro Asn Arg           
                820                 825                 830               

tcc cca ggc ttt gga atc aag aag gag aag aca ggc tgg gac acg tca       2605
Ser Pro Gly Phe Gly Ile Lys Lys Glu Lys Thr Gly Trp Asp Thr Ser           
            835                 840                 845                   

gaa agt gag ctg agt gag ggt gag ctg gag agg cgg cgg cgg aca ctc       2653
Glu Ser Glu Leu Ser Glu Gly Glu Leu Glu Arg Arg Arg Arg Thr Leu           
        850                 855                 860                       

cta cag cag ctg gat gat cac cag tga cccaatgagc tgttctctgc             2700
Leu Gln Gln Leu Asp Asp His Gln                                           
    865                 870                                               

ctcgggtctg tgtgaggcca tggctcctgg gccaccctca ccgtctgcct cagacttctt     2760

ccttagtctg gtctgtgtcc actttttcta aagtaacccc acccccagca caccattgtt     2820

ggcacctctc aaggttgctc ttggtgttca agggtcccct actccctgga ctagtgcagt     2880

ccttgccctc agccccagac cagagatggg tggtatatgc catgtggggt gggtgatgcc     2940

agtagataaa agtgtgagag aaggggtctc cagggaagag tcacaggctg ttggacacag     3000

cctgggtggc agagggcagg gtcatcaccc tctagcatca gtgcctgctc ctgcctgccc     3060

tggccctgag gctccaccac ttcttcctcc acccaggacc taatgtacgt gtgttttgtt     3120

ttttgttttt taaataacaa tatttataac atggaaaaaa aaaaaaaaaa aa             3172


<210>  334
<211>  871
<212>  PRT
<213>  Homo sapiens

<400>  334

Met Met Pro Pro Pro Phe Met Pro Pro Pro Gly Ile Pro Pro Pro Phe 
1               5                   10                  15      


Pro Pro Met Gly Leu Pro Pro Met Ser Gln Arg Pro Pro Ala Ile Pro 
            20                  25                  30          


Pro Met Pro Pro Gly Ile Leu Pro Pro Met Leu Pro Pro Met Gly Ala 
        35                  40                  45              


Pro Pro Pro Leu Thr Gln Ile Pro Gly Met Val Pro Pro Met Met Pro 
    50                  55                  60                  


Gly Met Leu Met Pro Ala Val Pro Val Thr Ala Ala Thr Ala Pro Gly 
65                  70                  75                  80  


Ala Asp Thr Ala Ser Ser Ala Val Ala Gly Thr Gly Pro Pro Arg Ala 
                85                  90                  95      


Leu Trp Ser Glu His Val Ala Pro Asp Gly Arg Ile Tyr Tyr Tyr Asn 
            100                 105                 110         


Ala Asp Asp Lys Gln Ser Val Trp Glu Lys Pro Ser Val Leu Lys Ser 
        115                 120                 125             


Lys Ala Glu Leu Leu Leu Ser Gln Cys Pro Trp Lys Glu Tyr Lys Ser 
    130                 135                 140                 


Asp Thr Gly Lys Pro Tyr Tyr Tyr Asn Asn Gln Ser Lys Glu Ser Arg 
145                 150                 155                 160 


Trp Thr Arg Pro Lys Asp Leu Asp Asp Leu Glu Val Leu Val Lys Gln 
                165                 170                 175     


Glu Ala Ala Gly Lys Gln Gln Gln Gln Leu Pro Gln Thr Leu Gln Pro 
            180                 185                 190         


Gln Pro Pro Gln Pro Gln Pro Asp Pro Pro Pro Val Pro Pro Gly Pro 
        195                 200                 205             


Thr Pro Val Pro Thr Gly Leu Leu Glu Pro Glu Pro Gly Gly Ser Glu 
    210                 215                 220                 


Asp Cys Asp Val Leu Glu Ala Thr Gln Pro Leu Glu Gln Gly Phe Leu 
225                 230                 235                 240 


Gln Gln Leu Glu Glu Gly Pro Ser Ser Ser Gly Gln His Gln Pro Gln 
                245                 250                 255     


Gln Glu Glu Glu Glu Ser Lys Pro Glu Pro Glu Arg Ser Gly Leu Ser 
            260                 265                 270         


Trp Ser Asn Arg Glu Lys Ala Lys Gln Ala Phe Lys Glu Leu Leu Arg 
        275                 280                 285             


Asp Lys Ala Val Pro Ser Asn Ala Ser Trp Glu Gln Ala Met Lys Met 
    290                 295                 300                 


Val Val Thr Asp Pro Arg Tyr Ser Ala Leu Pro Lys Leu Ser Glu Lys 
305                 310                 315                 320 


Lys Gln Ala Phe Asn Ala Tyr Lys Ala Gln Arg Glu Lys Glu Glu Lys 
                325                 330                 335     


Glu Glu Ala Arg Leu Arg Ala Lys Glu Ala Lys Gln Thr Leu Gln His 
            340                 345                 350         


Phe Leu Glu Gln His Glu Arg Met Thr Ser Thr Thr Arg Tyr Arg Arg 
        355                 360                 365             


Ala Glu Gln Thr Phe Gly Glu Leu Glu Val Trp Ala Val Val Pro Glu 
    370                 375                 380                 


Arg Asp Arg Lys Glu Val Tyr Asp Asp Val Leu Phe Phe Leu Ala Lys 
385                 390                 395                 400 


Lys Glu Lys Glu Gln Ala Lys Gln Leu Arg Arg Arg Asn Ile Gln Ala 
                405                 410                 415     


Leu Lys Ser Ile Leu Asp Gly Met Ser Ser Val Asn Phe Gln Thr Thr 
            420                 425                 430         


Trp Ser Gln Ala Gln Gln Tyr Leu Met Asp Asn Pro Ser Phe Ala Gln 
        435                 440                 445             


Asp His Gln Leu Gln Asn Met Asp Lys Glu Asp Ala Leu Ile Cys Phe 
    450                 455                 460                 


Glu Glu His Ile Arg Ala Leu Glu Arg Glu Glu Glu Glu Glu Arg Glu 
465                 470                 475                 480 


Arg Ala Arg Leu Arg Glu Arg Arg Gln Gln Arg Lys Asn Arg Glu Ala 
                485                 490                 495     


Phe Gln Thr Phe Leu Asp Glu Leu His Glu Thr Gly Gln Leu His Ser 
            500                 505                 510         


Met Ser Thr Trp Met Glu Leu Tyr Pro Ala Val Ser Thr Asp Val Arg 
        515                 520                 525             


Phe Ala Asn Met Leu Gly Gln Pro Gly Ser Thr Pro Leu Asp Leu Phe 
    530                 535                 540                 


Lys Phe Tyr Val Glu Glu Leu Lys Ala Arg Phe His Asp Glu Lys Lys 
545                 550                 555                 560 


Ile Ile Lys Asp Ile Leu Lys Asp Arg Gly Phe Cys Val Glu Val Asn 
                565                 570                 575     


Thr Ala Phe Glu Asp Phe Ala His Val Ile Ser Phe Asp Lys Arg Ala 
            580                 585                 590         


Ala Ala Leu Asp Ala Gly Asn Ile Lys Leu Thr Phe Asn Ser Leu Leu 
        595                 600                 605             


Glu Lys Ala Glu Ala Arg Glu Arg Glu Arg Glu Lys Glu Glu Ala Arg 
    610                 615                 620                 


Arg Met Arg Arg Arg Glu Ala Ala Phe Arg Ser Met Leu Arg Gln Ala 
625                 630                 635                 640 


Val Pro Ala Leu Glu Leu Gly Thr Ala Trp Glu Glu Val Arg Glu Arg 
                645                 650                 655     


Phe Val Cys Asp Ser Ala Phe Glu Gln Ile Thr Leu Glu Ser Glu Arg 
            660                 665                 670         


Ile Arg Leu Phe Arg Glu Phe Leu Gln Val Leu Glu Gln Thr Glu Cys 
        675                 680                 685             


Gln His Leu His Thr Lys Gly Arg Lys His Gly Arg Lys Gly Lys Lys 
    690                 695                 700                 


His His His Lys Arg Ser His Ser Pro Ser Gly Ser Glu Ser Glu Glu 
705                 710                 715                 720 


Glu Glu Leu Pro Pro Pro Ser Leu Arg Pro Pro Lys Arg Arg Arg Arg 
                725                 730                 735     


Asn Pro Ser Glu Ser Gly Ser Glu Pro Ser Ser Ser Leu Asp Ser Val 
            740                 745                 750         


Glu Ser Gly Gly Ala Ala Leu Gly Gly Arg Gly Ser Pro Ser Ser His 
        755                 760                 765             


Leu Leu Gly Ala Asp His Gly Leu Arg Lys Ala Lys Lys Pro Lys Lys 
    770                 775                 780                 


Lys Thr Lys Lys Arg Arg His Lys Ser Asn Ser Pro Glu Ser Glu Thr 
785                 790                 795                 800 


Asp Pro Glu Glu Lys Ala Gly Lys Glu Ser Asp Glu Lys Glu Gln Glu 
                805                 810                 815     


Gln Asp Lys Asp Arg Glu Leu Gln Gln Ala Glu Leu Pro Asn Arg Ser 
            820                 825                 830         


Pro Gly Phe Gly Ile Lys Lys Glu Lys Thr Gly Trp Asp Thr Ser Glu 
        835                 840                 845             


Ser Glu Leu Ser Glu Gly Glu Leu Glu Arg Arg Arg Arg Thr Leu Leu 
    850                 855                 860                 


Gln Gln Leu Asp Asp His Gln 
865                 870     


<210>  335
<211>  4217
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (56)..(3880)

<400>  335
agtccctctt tgggtgacct gtgcctgctt cgtgcctggt gtgacgtctc tcagg atg        58
                                                             Met          
                                                             1            

cct gag ccg ggg aag aag cca gtc tca gct ttt agc aag aag cca cgg        106
Pro Glu Pro Gly Lys Lys Pro Val Ser Ala Phe Ser Lys Lys Pro Arg           
            5                   10                  15                    

tca gtg gaa gtg gcc gca ggc agc cct gcc gtg ttc gag gcc gag aca        154
Ser Val Glu Val Ala Ala Gly Ser Pro Ala Val Phe Glu Ala Glu Thr           
        20                  25                  30                        

gag cgg gca gga gtg aag gtg cgc tgg cag cgc gga ggc agt gac atc        202
Glu Arg Ala Gly Val Lys Val Arg Trp Gln Arg Gly Gly Ser Asp Ile           
    35                  40                  45                            

agc gcc agc aac aag tac ggc ctg gcc aca gag ggc aca cgg cat acg        250
Ser Ala Ser Asn Lys Tyr Gly Leu Ala Thr Glu Gly Thr Arg His Thr           
50                  55                  60                  65            

ctg aca gtg cgg gaa gtg ggc cct gcc gac cag gga tct tac gca gtc        298
Leu Thr Val Arg Glu Val Gly Pro Ala Asp Gln Gly Ser Tyr Ala Val           
                70                  75                  80                

att gct ggc tcc tcc aag gtc aag ttc gac ctc aag gtc ata gag gca        346
Ile Ala Gly Ser Ser Lys Val Lys Phe Asp Leu Lys Val Ile Glu Ala           
            85                  90                  95                    

gag aag gca gag ccc atg ctg gcc cct gcc cct gcc cct gct gag gcc        394
Glu Lys Ala Glu Pro Met Leu Ala Pro Ala Pro Ala Pro Ala Glu Ala           
        100                 105                 110                       

act gga gcc cct gga gaa gcc ccg gcc cca gcc gct gag ctg gga gaa        442
Thr Gly Ala Pro Gly Glu Ala Pro Ala Pro Ala Ala Glu Leu Gly Glu           
    115                 120                 125                           

agt gcc cca agt ccc aaa ggg tca agc tca gca gct ctc aat ggt cct        490
Ser Ala Pro Ser Pro Lys Gly Ser Ser Ser Ala Ala Leu Asn Gly Pro           
130                 135                 140                 145           

acc cct gga gcc ccc gat gac ccc att ggc ctc ttc gtg atg cgg cca        538
Thr Pro Gly Ala Pro Asp Asp Pro Ile Gly Leu Phe Val Met Arg Pro           
                150                 155                 160               

cag gat ggc gag gtg acc gtg ggt ggc agc atc acc ttc tca gcc cgc        586
Gln Asp Gly Glu Val Thr Val Gly Gly Ser Ile Thr Phe Ser Ala Arg           
            165                 170                 175                   

gtg gcc ggc gcc agc ctc ctg aag ccg cct gtg gtc aag tgg ttc aag        634
Val Ala Gly Ala Ser Leu Leu Lys Pro Pro Val Val Lys Trp Phe Lys           
        180                 185                 190                       

ggc aaa tgg gtg gac ctg agc agc aag gtg ggc cag cac ctg cag ctg        682
Gly Lys Trp Val Asp Leu Ser Ser Lys Val Gly Gln His Leu Gln Leu           
    195                 200                 205                           

cac gac agc tac gac cgc gcc agc aag gtc tat ctg ttc gag ctg cac        730
His Asp Ser Tyr Asp Arg Ala Ser Lys Val Tyr Leu Phe Glu Leu His           
210                 215                 220                 225           

atc acc gat gcc cag cct gcc ttc act ggc agc tac cgc tgt gag gtg        778
Ile Thr Asp Ala Gln Pro Ala Phe Thr Gly Ser Tyr Arg Cys Glu Val           
                230                 235                 240               

tcc acc aag gac aaa ttt gac tgc tcc aac ttc aat ctc act gtc cac        826
Ser Thr Lys Asp Lys Phe Asp Cys Ser Asn Phe Asn Leu Thr Val His           
            245                 250                 255                   

gag gcc atg ggc acc gga gac ctg gac ctc cta tca gcc ttc cgc cgc        874
Glu Ala Met Gly Thr Gly Asp Leu Asp Leu Leu Ser Ala Phe Arg Arg           
        260                 265                 270                       

acg agc ctg gct gga ggt ggt cgg cgg atc agt gat agc cat gag gac        922
Thr Ser Leu Ala Gly Gly Gly Arg Arg Ile Ser Asp Ser His Glu Asp           
    275                 280                 285                           

act ggg att ctg gac ttc agc tca ctg ctg aaa aag aga gac agt ttc        970
Thr Gly Ile Leu Asp Phe Ser Ser Leu Leu Lys Lys Arg Asp Ser Phe           
290                 295                 300                 305           

cgg acc ccg agg gac tcg aag ctg gag gca cca gca gag gag gac gtg       1018
Arg Thr Pro Arg Asp Ser Lys Leu Glu Ala Pro Ala Glu Glu Asp Val           
                310                 315                 320               

tgg gag atc cta cgg cag gca ccc cca tct gag tac gag cgc atc gcc       1066
Trp Glu Ile Leu Arg Gln Ala Pro Pro Ser Glu Tyr Glu Arg Ile Ala           
            325                 330                 335                   

ttc cag tac ggc gtc act gac ctg cgc ggc atg cta aag agg ctc aag       1114
Phe Gln Tyr Gly Val Thr Asp Leu Arg Gly Met Leu Lys Arg Leu Lys           
        340                 345                 350                       

ggc atg agg cgc gat gag aag aag agc aca gcc ttt cag aag aag ctg       1162
Gly Met Arg Arg Asp Glu Lys Lys Ser Thr Ala Phe Gln Lys Lys Leu           
    355                 360                 365                           

gag ccg gcc tac cag gtg agc aaa ggc cac aag atc cgg ctg acc gtg       1210
Glu Pro Ala Tyr Gln Val Ser Lys Gly His Lys Ile Arg Leu Thr Val           
370                 375                 380                 385           

gaa ctg gct gac cat gac gct gag gtc aaa tgg ctc aag aat ggc cag       1258
Glu Leu Ala Asp His Asp Ala Glu Val Lys Trp Leu Lys Asn Gly Gln           
                390                 395                 400               

gag atc cag atg agc ggc agc aag tac atc ttt gag tcc atc ggt gcc       1306
Glu Ile Gln Met Ser Gly Ser Lys Tyr Ile Phe Glu Ser Ile Gly Ala           
            405                 410                 415                   

aag cgt acc ctg acc atc agc cag tgc tca ttg gcg gac gac gca gcc       1354
Lys Arg Thr Leu Thr Ile Ser Gln Cys Ser Leu Ala Asp Asp Ala Ala           
        420                 425                 430                       

tac cag tgc gtg gtg ggt ggc gag aag tgt agc acg gag ctc ttt gtg       1402
Tyr Gln Cys Val Val Gly Gly Glu Lys Cys Ser Thr Glu Leu Phe Val           
    435                 440                 445                           

aaa gag ccc cct gtg ctc atc acg cgc ccc ttg gag gac cag ctg gtg       1450
Lys Glu Pro Pro Val Leu Ile Thr Arg Pro Leu Glu Asp Gln Leu Val           
450                 455                 460                 465           

atg gtg ggg cag cgg gtg gag ttt gag tgt gaa gta tcg gag gag ggg       1498
Met Val Gly Gln Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu Gly           
                470                 475                 480               

gcg caa gtc aaa tgg ctg aag gac ggg gtg gag ctg acc cgg gag gag       1546
Ala Gln Val Lys Trp Leu Lys Asp Gly Val Glu Leu Thr Arg Glu Glu           
            485                 490                 495                   

acc ttc aaa tac cgg ttc aag aag gac ggg cag aga cac cac ctg atc       1594
Thr Phe Lys Tyr Arg Phe Lys Lys Asp Gly Gln Arg His His Leu Ile           
        500                 505                 510                       

atc aac gag gcc atg ctg gag gac gcg ggg cac tat gca ctg tgc act       1642
Ile Asn Glu Ala Met Leu Glu Asp Ala Gly His Tyr Ala Leu Cys Thr           
    515                 520                 525                           

agc ggg ggc cag gcg ctg gct gag ctc att gtg cag gaa aag aag ctg       1690
Ser Gly Gly Gln Ala Leu Ala Glu Leu Ile Val Gln Glu Lys Lys Leu           
530                 535                 540                 545           

gag gtg tac cag agc atc gca gac ctg atg gtg ggc gca aag gac cag       1738
Glu Val Tyr Gln Ser Ile Ala Asp Leu Met Val Gly Ala Lys Asp Gln           
                550                 555                 560               

gcg gtg ttc aaa tgt gag gtc tca gat gag aat gtt cgg ggt gtg tgg       1786
Ala Val Phe Lys Cys Glu Val Ser Asp Glu Asn Val Arg Gly Val Trp           
            565                 570                 575                   

ctg aag aat ggg aag gag ctg gtg ccc gac agc cgc ata aag gtg tcc       1834
Leu Lys Asn Gly Lys Glu Leu Val Pro Asp Ser Arg Ile Lys Val Ser           
        580                 585                 590                       

cac atc ggg cgg gtc cac aaa ctg acc att gac gac gtc aca cct gcc       1882
His Ile Gly Arg Val His Lys Leu Thr Ile Asp Asp Val Thr Pro Ala           
    595                 600                 605                           

gac gag gct gac tac agc ttt gtg ccc gag ggc ttc gcc tgc aac ctg       1930
Asp Glu Ala Asp Tyr Ser Phe Val Pro Glu Gly Phe Ala Cys Asn Leu           
610                 615                 620                 625           

tca gcc aag ctc cac ttc atg gag gtc aag att gac ttc gta ccc agg       1978
Ser Ala Lys Leu His Phe Met Glu Val Lys Ile Asp Phe Val Pro Arg           
                630                 635                 640               

cag gaa cct ccc aag atc cac ctg gac tgc cca ggc cgc ata cca gac       2026
Gln Glu Pro Pro Lys Ile His Leu Asp Cys Pro Gly Arg Ile Pro Asp           
            645                 650                 655                   

acc att gtg gtt gta gct gga aat aag cta cgt ctg gac gtc cct atc       2074
Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg Leu Asp Val Pro Ile           
        660                 665                 670                       

tct ggg gac cct gct ccc act gtg atc tgg cag aag gct atc acg cag       2122
Ser Gly Asp Pro Ala Pro Thr Val Ile Trp Gln Lys Ala Ile Thr Gln           
    675                 680                 685                           

ggg aat aag gcc cca gcc agg cca gcc cca gat gcc cca gag gac aca       2170
Gly Asn Lys Ala Pro Ala Arg Pro Ala Pro Asp Ala Pro Glu Asp Thr           
690                 695                 700                 705           

ggt gac agc gat gag tgg gtg ttt gac aag aag ctg ctg tgt gag acc       2218
Gly Asp Ser Asp Glu Trp Val Phe Asp Lys Lys Leu Leu Cys Glu Thr           
                710                 715                 720               

gag ggc cgg gtc cgc gtg gag acc acc aag gac cgc agc atc ttc acg       2266
Glu Gly Arg Val Arg Val Glu Thr Thr Lys Asp Arg Ser Ile Phe Thr           
            725                 730                 735                   

gtc gag ggg gca gag aag gaa gat gag ggc gtc tac acg gtc aca gtg       2314
Val Glu Gly Ala Glu Lys Glu Asp Glu Gly Val Tyr Thr Val Thr Val           
        740                 745                 750                       

aag aac cct gtg ggc gag gac cag gtc aac ctc aca gtc aag gtc atc       2362
Lys Asn Pro Val Gly Glu Asp Gln Val Asn Leu Thr Val Lys Val Ile           
    755                 760                 765                           

gac gtg cca gac gca cct gcg gcc ccc aag atc agc aac gtg gga gag       2410
Asp Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu           
770                 775                 780                 785           

gac tcc tgc aca gta cag tgg gag ccg cct gcc tac gat ggc ggg cag       2458
Asp Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln           
                790                 795                 800               

ccc atc ctg ggc tac atc ctg gag cgc aag aag aag aag agc tac cgg       2506
Pro Ile Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg           
            805                 810                 815                   

tgg atg cgg ctg aac ttc gac ctg att cag gag ctg agt cat gaa gcg       2554
Trp Met Arg Leu Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu Ala           
        820                 825                 830                       

cgg cgc atg atc gag ggc gtg gtg tac gag atg cgc gtc tac gcg gtc       2602
Arg Arg Met Ile Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala Val           
    835                 840                 845                           

aac gcc atc ggc atg tcc agg ccc agc cct gcc tcc cag ccc ttc atg       2650
Asn Ala Ile Gly Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met           
850                 855                 860                 865           

cct atc ggt ccc ccc agc gaa ccc acc cac ctg gca gta gag gac gtc       2698
Pro Ile Gly Pro Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp Val           
                870                 875                 880               

tct gac acc acg gtc tcc ctc aag tgg cgg ccc cca gag cgc gtg gga       2746
Ser Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly           
            885                 890                 895                   

gca gga ggc ctg gat ggc tac agc gtg gag tac tgc cca gag ggc tgc       2794
Ala Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly Cys           
        900                 905                 910                       

tca gag tgg gtg gct gcc ctg cag ggg ctg aca gag cac aca tcg ata       2842
Ser Glu Trp Val Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser Ile           
    915                 920                 925                           

ctg gtg aag gac ctg ccc acg ggg gcc cgg ctg ctt ttc cga gtg cgg       2890
Leu Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg           
930                 935                 940                 945           

gca cac aat atg gca ggg cct gga gcc cct gtt acc acc acg gag ccg       2938
Ala His Asn Met Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu Pro           
                950                 955                 960               

gtg aca gtg cag gag atc ctg caa cgg cca cgg ctt cag ctg ccc agg       2986
Val Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg           
            965                 970                 975                   

cac ctg cgc cag acc att cag aag aag gtc ggg gag cct gtg aac ctt       3034
His Leu Arg Gln Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu           
        980                 985                 990                       

ctc atc cct ttc cag ggc aag  ccc cgg cct cag gtg  acc tgg acc aaa     3082
Leu Ile Pro Phe Gln Gly Lys  Pro Arg Pro Gln Val  Thr Trp Thr Lys         
    995                 1000                 1005                         

gag  ggg cag ccc ctg gca  ggc gag gag gtg agc  atc cgc aac agc        3127
Glu  Gly Gln Pro Leu Ala  Gly Glu Glu Val Ser  Ile Arg Asn Ser            
1010                 1015                 1020                            

ccc  aca gac acc atc ctg  ttc atc cgg gcc gct  cgc cgc gtg cat        3172
Pro  Thr Asp Thr Ile Leu  Phe Ile Arg Ala Ala  Arg Arg Val His            
1025                 1030                 1035                            

tca  ggc act tac cag gtg  acg gtg cgc att gag  aac atg gag gac        3217
Ser  Gly Thr Tyr Gln Val  Thr Val Arg Ile Glu  Asn Met Glu Asp            
1040                 1045                 1050                            

aag  gcc acg ctg gtg ctg  cag gtt gtt gac aag  cca agt cct ccc        3262
Lys  Ala Thr Leu Val Leu  Gln Val Val Asp Lys  Pro Ser Pro Pro            
1055                 1060                 1065                            

cag  gat ctc cgg gtg act  gac gcc tgg ggt ctt  aat gtg gct ctg        3307
Gln  Asp Leu Arg Val Thr  Asp Ala Trp Gly Leu  Asn Val Ala Leu            
1070                 1075                 1080                            

gag  tgg aag cca ccc cag  gat gtc ggc aac acg  gag ctc tgg ggg        3352
Glu  Trp Lys Pro Pro Gln  Asp Val Gly Asn Thr  Glu Leu Trp Gly            
1085                 1090                 1095                            

tac  aca gtg cag aaa gcc  gac aag aag acc atg  gag tgg ttc acc        3397
Tyr  Thr Val Gln Lys Ala  Asp Lys Lys Thr Met  Glu Trp Phe Thr            
1100                 1105                 1110                            

gtc  ttg gag cat tac cgc  cgc acc cac tgc gtg  gtg cca gag ctc        3442
Val  Leu Glu His Tyr Arg  Arg Thr His Cys Val  Val Pro Glu Leu            
1115                 1120                 1125                            

atc  att ggc aat ggc tac  tac ttc cgc gtc ttc  agc cag aat atg        3487
Ile  Ile Gly Asn Gly Tyr  Tyr Phe Arg Val Phe  Ser Gln Asn Met            
1130                 1135                 1140                            

gtt  ggc ttt agt gac aga  gcg gcc acc acc aag  gag ccc gtc ttt        3532
Val  Gly Phe Ser Asp Arg  Ala Ala Thr Thr Lys  Glu Pro Val Phe            
1145                 1150                 1155                            

atc  ccc aga cca ggc atc  acc tat gag cca ccc  aac tat aag gcc        3577
Ile  Pro Arg Pro Gly Ile  Thr Tyr Glu Pro Pro  Asn Tyr Lys Ala            
1160                 1165                 1170                            

ctg  gac ttc tcc gag gcc  cca agc ttc acc cag  ccc ctg gtg aac        3622
Leu  Asp Phe Ser Glu Ala  Pro Ser Phe Thr Gln  Pro Leu Val Asn            
1175                 1180                 1185                            

cgc  tcg gtc atc gcg ggc  tac act gct atg ctc  tgc tgt gct gtc        3667
Arg  Ser Val Ile Ala Gly  Tyr Thr Ala Met Leu  Cys Cys Ala Val            
1190                 1195                 1200                            

cgg  ggt agc ccc aag ccc  aag att tcc tgg ttc  aag aat ggc ctg        3712
Arg  Gly Ser Pro Lys Pro  Lys Ile Ser Trp Phe  Lys Asn Gly Leu            
1205                 1210                 1215                            

gac  ctg gga gaa gac gcc  cgc ttc cgc atg ttc  agc aag cag gga        3757
Asp  Leu Gly Glu Asp Ala  Arg Phe Arg Met Phe  Ser Lys Gln Gly            
1220                 1225                 1230                            

gtg  ttg act ctg gag att  aga aag ccc tgc ccc  ttt gac ggg ggc        3802
Val  Leu Thr Leu Glu Ile  Arg Lys Pro Cys Pro  Phe Asp Gly Gly            
1235                 1240                 1245                            

atc  tat gtc tgc agg gcc  acc aac tta cag ggc  gag gca cgg tgt        3847
Ile  Tyr Val Cys Arg Ala  Thr Asn Leu Gln Gly  Glu Ala Arg Cys            
1250                 1255                 1260                            

gag  tgc cgc ctg gag gtg  cga gtg cct cag tga ccaggctggc              3890
Glu  Cys Arg Leu Glu Val  Arg Val Pro Gln                                 
1265                 1270                                                 

tcctggggat ggccaggtac aaccggatgc cagccccgtg ccaggagcct ggagggaagt     3950

tggggaaacc cctccctact gttggatgta tgtgtgacaa gtgtgtctcc tgtgctgcga     4010

tgggggatca gcagggcagt tgtcgggcag tcctgagtgg gtgttgcaca gactggtcca     4070

cagggctcct gaaggaagcc cctggatctt tggggtaaaa ggagggtggc ctcaagaaac     4130

aatgtctggg gacaggcctt tctggcctgc tatgtcttcc caatgtttat tgggcaataa     4190

aagataagtg cagtcacaga gaactca                                         4217


<210>  336
<211>  1274
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Pro Glu Pro Gly Lys Lys Pro Val Ser Ala Phe Ser Lys Lys Pro 
1               5                   10                  15      


Arg Ser Val Glu Val Ala Ala Gly Ser Pro Ala Val Phe Glu Ala Glu 
            20                  25                  30          


Thr Glu Arg Ala Gly Val Lys Val Arg Trp Gln Arg Gly Gly Ser Asp 
        35                  40                  45              


Ile Ser Ala Ser Asn Lys Tyr Gly Leu Ala Thr Glu Gly Thr Arg His 
    50                  55                  60                  


Thr Leu Thr Val Arg Glu Val Gly Pro Ala Asp Gln Gly Ser Tyr Ala 
65                  70                  75                  80  


Val Ile Ala Gly Ser Ser Lys Val Lys Phe Asp Leu Lys Val Ile Glu 
                85                  90                  95      


Ala Glu Lys Ala Glu Pro Met Leu Ala Pro Ala Pro Ala Pro Ala Glu 
            100                 105                 110         


Ala Thr Gly Ala Pro Gly Glu Ala Pro Ala Pro Ala Ala Glu Leu Gly 
        115                 120                 125             


Glu Ser Ala Pro Ser Pro Lys Gly Ser Ser Ser Ala Ala Leu Asn Gly 
    130                 135                 140                 


Pro Thr Pro Gly Ala Pro Asp Asp Pro Ile Gly Leu Phe Val Met Arg 
145                 150                 155                 160 


Pro Gln Asp Gly Glu Val Thr Val Gly Gly Ser Ile Thr Phe Ser Ala 
                165                 170                 175     


Arg Val Ala Gly Ala Ser Leu Leu Lys Pro Pro Val Val Lys Trp Phe 
            180                 185                 190         


Lys Gly Lys Trp Val Asp Leu Ser Ser Lys Val Gly Gln His Leu Gln 
        195                 200                 205             


Leu His Asp Ser Tyr Asp Arg Ala Ser Lys Val Tyr Leu Phe Glu Leu 
    210                 215                 220                 


His Ile Thr Asp Ala Gln Pro Ala Phe Thr Gly Ser Tyr Arg Cys Glu 
225                 230                 235                 240 


Val Ser Thr Lys Asp Lys Phe Asp Cys Ser Asn Phe Asn Leu Thr Val 
                245                 250                 255     


His Glu Ala Met Gly Thr Gly Asp Leu Asp Leu Leu Ser Ala Phe Arg 
            260                 265                 270         


Arg Thr Ser Leu Ala Gly Gly Gly Arg Arg Ile Ser Asp Ser His Glu 
        275                 280                 285             


Asp Thr Gly Ile Leu Asp Phe Ser Ser Leu Leu Lys Lys Arg Asp Ser 
    290                 295                 300                 


Phe Arg Thr Pro Arg Asp Ser Lys Leu Glu Ala Pro Ala Glu Glu Asp 
305                 310                 315                 320 


Val Trp Glu Ile Leu Arg Gln Ala Pro Pro Ser Glu Tyr Glu Arg Ile 
                325                 330                 335     


Ala Phe Gln Tyr Gly Val Thr Asp Leu Arg Gly Met Leu Lys Arg Leu 
            340                 345                 350         


Lys Gly Met Arg Arg Asp Glu Lys Lys Ser Thr Ala Phe Gln Lys Lys 
        355                 360                 365             


Leu Glu Pro Ala Tyr Gln Val Ser Lys Gly His Lys Ile Arg Leu Thr 
    370                 375                 380                 


Val Glu Leu Ala Asp His Asp Ala Glu Val Lys Trp Leu Lys Asn Gly 
385                 390                 395                 400 


Gln Glu Ile Gln Met Ser Gly Ser Lys Tyr Ile Phe Glu Ser Ile Gly 
                405                 410                 415     


Ala Lys Arg Thr Leu Thr Ile Ser Gln Cys Ser Leu Ala Asp Asp Ala 
            420                 425                 430         


Ala Tyr Gln Cys Val Val Gly Gly Glu Lys Cys Ser Thr Glu Leu Phe 
        435                 440                 445             


Val Lys Glu Pro Pro Val Leu Ile Thr Arg Pro Leu Glu Asp Gln Leu 
    450                 455                 460                 


Val Met Val Gly Gln Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu 
465                 470                 475                 480 


Gly Ala Gln Val Lys Trp Leu Lys Asp Gly Val Glu Leu Thr Arg Glu 
                485                 490                 495     


Glu Thr Phe Lys Tyr Arg Phe Lys Lys Asp Gly Gln Arg His His Leu 
            500                 505                 510         


Ile Ile Asn Glu Ala Met Leu Glu Asp Ala Gly His Tyr Ala Leu Cys 
        515                 520                 525             


Thr Ser Gly Gly Gln Ala Leu Ala Glu Leu Ile Val Gln Glu Lys Lys 
    530                 535                 540                 


Leu Glu Val Tyr Gln Ser Ile Ala Asp Leu Met Val Gly Ala Lys Asp 
545                 550                 555                 560 


Gln Ala Val Phe Lys Cys Glu Val Ser Asp Glu Asn Val Arg Gly Val 
                565                 570                 575     


Trp Leu Lys Asn Gly Lys Glu Leu Val Pro Asp Ser Arg Ile Lys Val 
            580                 585                 590         


Ser His Ile Gly Arg Val His Lys Leu Thr Ile Asp Asp Val Thr Pro 
        595                 600                 605             


Ala Asp Glu Ala Asp Tyr Ser Phe Val Pro Glu Gly Phe Ala Cys Asn 
    610                 615                 620                 


Leu Ser Ala Lys Leu His Phe Met Glu Val Lys Ile Asp Phe Val Pro 
625                 630                 635                 640 


Arg Gln Glu Pro Pro Lys Ile His Leu Asp Cys Pro Gly Arg Ile Pro 
                645                 650                 655     


Asp Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg Leu Asp Val Pro 
            660                 665                 670         


Ile Ser Gly Asp Pro Ala Pro Thr Val Ile Trp Gln Lys Ala Ile Thr 
        675                 680                 685             


Gln Gly Asn Lys Ala Pro Ala Arg Pro Ala Pro Asp Ala Pro Glu Asp 
    690                 695                 700                 


Thr Gly Asp Ser Asp Glu Trp Val Phe Asp Lys Lys Leu Leu Cys Glu 
705                 710                 715                 720 


Thr Glu Gly Arg Val Arg Val Glu Thr Thr Lys Asp Arg Ser Ile Phe 
                725                 730                 735     


Thr Val Glu Gly Ala Glu Lys Glu Asp Glu Gly Val Tyr Thr Val Thr 
            740                 745                 750         


Val Lys Asn Pro Val Gly Glu Asp Gln Val Asn Leu Thr Val Lys Val 
        755                 760                 765             


Ile Asp Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly 
    770                 775                 780                 


Glu Asp Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly 
785                 790                 795                 800 


Gln Pro Ile Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr 
                805                 810                 815     


Arg Trp Met Arg Leu Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu 
            820                 825                 830         


Ala Arg Arg Met Ile Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala 
        835                 840                 845             


Val Asn Ala Ile Gly Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe 
    850                 855                 860                 


Met Pro Ile Gly Pro Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp 
865                 870                 875                 880 


Val Ser Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val 
                885                 890                 895     


Gly Ala Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly 
            900                 905                 910         


Cys Ser Glu Trp Val Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser 
        915                 920                 925             


Ile Leu Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val 
    930                 935                 940                 


Arg Ala His Asn Met Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu 
945                 950                 955                 960 


Pro Val Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro 
                965                 970                 975     


Arg His Leu Arg Gln Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn 
            980                 985                 990         


Leu Leu Ile Pro Phe Gln Gly Lys  Pro Arg Pro Gln Val  Thr Trp Thr 
        995                 1000                 1005             


Lys Glu  Gly Gln Pro Leu Ala  Gly Glu Glu Val Ser  Ile Arg Asn 
    1010                 1015                 1020             


Ser Pro  Thr Asp Thr Ile Leu  Phe Ile Arg Ala Ala  Arg Arg Val 
    1025                 1030                 1035             


His Ser  Gly Thr Tyr Gln Val  Thr Val Arg Ile Glu  Asn Met Glu 
    1040                 1045                 1050             


Asp Lys  Ala Thr Leu Val Leu  Gln Val Val Asp Lys  Pro Ser Pro 
    1055                 1060                 1065             


Pro Gln  Asp Leu Arg Val Thr  Asp Ala Trp Gly Leu  Asn Val Ala 
    1070                 1075                 1080             


Leu Glu  Trp Lys Pro Pro Gln  Asp Val Gly Asn Thr  Glu Leu Trp 
    1085                 1090                 1095             


Gly Tyr  Thr Val Gln Lys Ala  Asp Lys Lys Thr Met  Glu Trp Phe 
    1100                 1105                 1110             


Thr Val  Leu Glu His Tyr Arg  Arg Thr His Cys Val  Val Pro Glu 
    1115                 1120                 1125             


Leu Ile  Ile Gly Asn Gly Tyr  Tyr Phe Arg Val Phe  Ser Gln Asn 
    1130                 1135                 1140             


Met Val  Gly Phe Ser Asp Arg  Ala Ala Thr Thr Lys  Glu Pro Val 
    1145                 1150                 1155             


Phe Ile  Pro Arg Pro Gly Ile  Thr Tyr Glu Pro Pro  Asn Tyr Lys 
    1160                 1165                 1170             


Ala Leu  Asp Phe Ser Glu Ala  Pro Ser Phe Thr Gln  Pro Leu Val 
    1175                 1180                 1185             


Asn Arg  Ser Val Ile Ala Gly  Tyr Thr Ala Met Leu  Cys Cys Ala 
    1190                 1195                 1200             


Val Arg  Gly Ser Pro Lys Pro  Lys Ile Ser Trp Phe  Lys Asn Gly 
    1205                 1210                 1215             


Leu Asp  Leu Gly Glu Asp Ala  Arg Phe Arg Met Phe  Ser Lys Gln 
    1220                 1225                 1230             


Gly Val  Leu Thr Leu Glu Ile  Arg Lys Pro Cys Pro  Phe Asp Gly 
    1235                 1240                 1245             


Gly Ile  Tyr Val Cys Arg Ala  Thr Asn Leu Gln Gly  Glu Ala Arg 
    1250                 1255                 1260             


Cys Glu  Cys Arg Leu Glu Val  Arg Val Pro Gln 
    1265                 1270                 


<210>  337
<211>  5472
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (175)..(2841)

<400>  337
tggataggag agctggcgca gctgccctgg tggcagtggc tgaagtggcg gcggcttcgg       60

cggctgcggc ggctgcaaca gcttcgggct cggggttttg gcggcggcgc cggcgggcta      120

ggctgcgcgg tgcggacccc ggcgcgcggt ccgggttgct ggggcggcgc gtag atg        177
                                                            Met           
                                                            1             

gag tct tgc tac att gcc cag gct ggt ctt gaa ctg cta ggc tca agc        225
Glu Ser Cys Tyr Ile Ala Gln Ala Gly Leu Glu Leu Leu Gly Ser Ser           
            5                   10                  15                    

agt tct ccc acc ttg acc tcc caa agc gct gag att aca gaa gat gcc        273
Ser Ser Pro Thr Leu Thr Ser Gln Ser Ala Glu Ile Thr Glu Asp Ala           
        20                  25                  30                        

tct aat gga gga gtt tct gag cag cac ccc tgg ccc agt ggc ttt gaa        321
Ser Asn Gly Gly Val Ser Glu Gln His Pro Trp Pro Ser Gly Phe Glu           
    35                  40                  45                            

agg gag ctc aaa cca gag act att tca agc cct gga tat cat atc ctg        369
Arg Glu Leu Lys Pro Glu Thr Ile Ser Ser Pro Gly Tyr His Ile Leu           
50                  55                  60                  65            

agg gcc aca gga gaa gag aac atg gct gtg agt ttg gat gac gac gtg        417
Arg Ala Thr Gly Glu Glu Asn Met Ala Val Ser Leu Asp Asp Asp Val           
                70                  75                  80                

ccg ctc atc ctg acc ttg gat gag ggt ggc agt gcc cca ctg gct ccc        465
Pro Leu Ile Leu Thr Leu Asp Glu Gly Gly Ser Ala Pro Leu Ala Pro           
            85                  90                  95                    

tcc aac ggc ctg ggc caa gaa gag cta cct agc aaa aat ggc ggc agc        513
Ser Asn Gly Leu Gly Gln Glu Glu Leu Pro Ser Lys Asn Gly Gly Ser           
        100                 105                 110                       

tat gcc atc cac gac tcc cag gcc ccc agt ctc agc tct ggg ggt gag        561
Tyr Ala Ile His Asp Ser Gln Ala Pro Ser Leu Ser Ser Gly Gly Glu           
    115                 120                 125                           

agt tcc ccc tcc agc ccc gca cac aac tgg gag atg aat tac caa gag        609
Ser Ser Pro Ser Ser Pro Ala His Asn Trp Glu Met Asn Tyr Gln Glu           
130                 135                 140                 145           

gca gca atc tac ctc cag gaa ggc gag aac aac gac aag ttc ttc acc        657
Ala Ala Ile Tyr Leu Gln Glu Gly Glu Asn Asn Asp Lys Phe Phe Thr           
                150                 155                 160               

cac ccc aag gat gcc aag gcg ctg gcg gcc tac ctc ttt gca cac aat        705
His Pro Lys Asp Ala Lys Ala Leu Ala Ala Tyr Leu Phe Ala His Asn           
            165                 170                 175                   

cac ctc ttc tac ctg atg gag ctg gcc acg gcc ctg ctg ctg ctg ctg        753
His Leu Phe Tyr Leu Met Glu Leu Ala Thr Ala Leu Leu Leu Leu Leu           
        180                 185                 190                       

ctc tcc ctg tgc gag gcc ccc gcc gtc ccc gca ctc cgg ctt ggc atc        801
Leu Ser Leu Cys Glu Ala Pro Ala Val Pro Ala Leu Arg Leu Gly Ile           
    195                 200                 205                           

tat gtc cac gcc acc ctg gag ctg ttt gcc ctg atg gtg gta gtg ttt        849
Tyr Val His Ala Thr Leu Glu Leu Phe Ala Leu Met Val Val Val Phe           
210                 215                 220                 225           

gaa ctc tgc atg aag tta cgc tgg ctg ggc ctc cac acc ttc atc cgg        897
Glu Leu Cys Met Lys Leu Arg Trp Leu Gly Leu His Thr Phe Ile Arg           
                230                 235                 240               

cac aag cgg acc atg gtc aag acc tcg gtg ctg gtg gtg cag ttt gtc        945
His Lys Arg Thr Met Val Lys Thr Ser Val Leu Val Val Gln Phe Val           
            245                 250                 255                   

gag gcc atc gtg gtg ttg gta cgg cag atg tcc cat gtg cgg gtg acc        993
Glu Ala Ile Val Val Leu Val Arg Gln Met Ser His Val Arg Val Thr           
        260                 265                 270                       

cga gca ctg cgc tgc att ttc ctg gtg gac tgt cgg tat tgc ggt ggc       1041
Arg Ala Leu Arg Cys Ile Phe Leu Val Asp Cys Arg Tyr Cys Gly Gly           
    275                 280                 285                           

gtc cgg cgc aac ctg cgg cag atc ttc cag tcc ctg ccg ccc ttc atg       1089
Val Arg Arg Asn Leu Arg Gln Ile Phe Gln Ser Leu Pro Pro Phe Met           
290                 295                 300                 305           

gac atc ctc ctg ctg ctg ctg ttc ttc atg atc atc ttt gcc atc ctc       1137
Asp Ile Leu Leu Leu Leu Leu Phe Phe Met Ile Ile Phe Ala Ile Leu           
                310                 315                 320               

ggt ttc tac ttg ttc tcc cct aac cct tca gac ccc tac ttc agc acc       1185
Gly Phe Tyr Leu Phe Ser Pro Asn Pro Ser Asp Pro Tyr Phe Ser Thr           
            325                 330                 335                   

ctg gag aac agc atc gtc agt ctg ttt gtc ctt ctg acc aca gcc aat       1233
Leu Glu Asn Ser Ile Val Ser Leu Phe Val Leu Leu Thr Thr Ala Asn           
        340                 345                 350                       

ttc cca gat gtg atg atg ccc tcc tac tcc cgg aac ccc tgg tcc tgc       1281
Phe Pro Asp Val Met Met Pro Ser Tyr Ser Arg Asn Pro Trp Ser Cys           
    355                 360                 365                           

gtc ttc ttc atc gtg tac ctc tcc atc gag ctg tat ttc atc atg aac       1329
Val Phe Phe Ile Val Tyr Leu Ser Ile Glu Leu Tyr Phe Ile Met Asn           
370                 375                 380                 385           

ctg ctt ctg gct gtg gtg ttc gac acc ttc aat gac att gag aaa cgc       1377
Leu Leu Leu Ala Val Val Phe Asp Thr Phe Asn Asp Ile Glu Lys Arg           
                390                 395                 400               

aag ttc aag tct ttg cta ctg cac aag cga acc gct atc cag cat gcc       1425
Lys Phe Lys Ser Leu Leu Leu His Lys Arg Thr Ala Ile Gln His Ala           
            405                 410                 415                   

tac cgc ctg ctc atc agc cag agg agg cct gcc ggc atc tcc tac agg       1473
Tyr Arg Leu Leu Ile Ser Gln Arg Arg Pro Ala Gly Ile Ser Tyr Arg           
        420                 425                 430                       

cag ttt gaa ggc ctc atg cgc ttc tac aag ccc cgg atg agt gcc agg       1521
Gln Phe Glu Gly Leu Met Arg Phe Tyr Lys Pro Arg Met Ser Ala Arg           
    435                 440                 445                           

gag cgc tat ctt acc ttc aag gcc ctg aat cag aac aac aca ccc ctg       1569
Glu Arg Tyr Leu Thr Phe Lys Ala Leu Asn Gln Asn Asn Thr Pro Leu           
450                 455                 460                 465           

ctc agc cta aag gac ttt tac gat atc tac gaa gtt gct gct ttg aag       1617
Leu Ser Leu Lys Asp Phe Tyr Asp Ile Tyr Glu Val Ala Ala Leu Lys           
                470                 475                 480               

tgg aag gcc aag aaa aac aga gag cac tgg ttt gat gag ctt ccc agg       1665
Trp Lys Ala Lys Lys Asn Arg Glu His Trp Phe Asp Glu Leu Pro Arg           
            485                 490                 495                   

acg gcg ctc ctc atc ttc aaa ggt att aat atc ctt gtg aag tcc aag       1713
Thr Ala Leu Leu Ile Phe Lys Gly Ile Asn Ile Leu Val Lys Ser Lys           
        500                 505                 510                       

gcc ttc cag tat ttc atg tac ttg gtg gtg gca gtc aac ggg gtc tgg       1761
Ala Phe Gln Tyr Phe Met Tyr Leu Val Val Ala Val Asn Gly Val Trp           
    515                 520                 525                           

atc ctc gtg gag aca ttt atg ctg aaa ggt ggg aac ttc ttc tcc aag       1809
Ile Leu Val Glu Thr Phe Met Leu Lys Gly Gly Asn Phe Phe Ser Lys           
530                 535                 540                 545           

cac gtg ccc tgg agt tac ctc gtc ttt cta act atc tat ggg gtg gag       1857
His Val Pro Trp Ser Tyr Leu Val Phe Leu Thr Ile Tyr Gly Val Glu           
                550                 555                 560               

ctg ttc ctg aag gtt gcc ggc ctg ggc cct gtg gag tac ttg tct tcc       1905
Leu Phe Leu Lys Val Ala Gly Leu Gly Pro Val Glu Tyr Leu Ser Ser           
            565                 570                 575                   

gga tgg aac ttg ttt gac ttc tcc gtg aca gtg ttc gcc ttc ctg gga       1953
Gly Trp Asn Leu Phe Asp Phe Ser Val Thr Val Phe Ala Phe Leu Gly           
        580                 585                 590                       

ctg ctg gcg ctg gcc ctc aac atg gag ccc ttc tat ttc atc gtg gtc       2001
Leu Leu Ala Leu Ala Leu Asn Met Glu Pro Phe Tyr Phe Ile Val Val           
    595                 600                 605                           

ctg cgc ccc ctc cag ctg ctg agg ttg ttt aag ttg aag gag cgc tac       2049
Leu Arg Pro Leu Gln Leu Leu Arg Leu Phe Lys Leu Lys Glu Arg Tyr           
610                 615                 620                 625           

cgc aac gtg ctg gac acc atg ttc gag ctg ctg ccc cgg atg gcc agc       2097
Arg Asn Val Leu Asp Thr Met Phe Glu Leu Leu Pro Arg Met Ala Ser           
                630                 635                 640               

ctg ggc ctc acc ctg ctc atc ttt tac tac tcc ttc gcc atc gtg ggc       2145
Leu Gly Leu Thr Leu Leu Ile Phe Tyr Tyr Ser Phe Ala Ile Val Gly           
            645                 650                 655                   

atg gag ttc ttc tgc ggg atc gtc ttc ccc aac tgc tgc aac acg agt       2193
Met Glu Phe Phe Cys Gly Ile Val Phe Pro Asn Cys Cys Asn Thr Ser           
        660                 665                 670                       

aca gtg gca gat gcc tac cgc tgg cgc aac cac acc gtg ggc aac agg       2241
Thr Val Ala Asp Ala Tyr Arg Trp Arg Asn His Thr Val Gly Asn Arg           
    675                 680                 685                           

acc gtg gtg gag gaa ggc tac tat tat ctc aat aat ttt gac aac atc       2289
Thr Val Val Glu Glu Gly Tyr Tyr Tyr Leu Asn Asn Phe Asp Asn Ile           
690                 695                 700                 705           

ctc aac agc ttt gtg acc ctg ttt gag ctc aca gtt gtc aac aac tgg       2337
Leu Asn Ser Phe Val Thr Leu Phe Glu Leu Thr Val Val Asn Asn Trp           
                710                 715                 720               

tac atc atc atg gaa ggc gtc acc tct cag acc tcc cac tgg agc cgc       2385
Tyr Ile Ile Met Glu Gly Val Thr Ser Gln Thr Ser His Trp Ser Arg           
            725                 730                 735                   

ctc tac ttc atg acc ttt tac att gtg acc atg gtg gtg atg acg atc       2433
Leu Tyr Phe Met Thr Phe Tyr Ile Val Thr Met Val Val Met Thr Ile           
        740                 745                 750                       

att gtc gcc ttt atc ctc gag gcc ttc gtc ttc cga atg aac tac agc       2481
Ile Val Ala Phe Ile Leu Glu Ala Phe Val Phe Arg Met Asn Tyr Ser           
    755                 760                 765                           

cgc aag aac cag gac tcg gaa gtt gat ggt ggc atc acc ctt gag aag       2529
Arg Lys Asn Gln Asp Ser Glu Val Asp Gly Gly Ile Thr Leu Glu Lys           
770                 775                 780                 785           

gaa atc tcc aaa gaa gag ctg gtt gcc gtc ctg gag ctc tac cgg gag       2577
Glu Ile Ser Lys Glu Glu Leu Val Ala Val Leu Glu Leu Tyr Arg Glu           
                790                 795                 800               

gca cgg ggg gcc tcc tcg gat gtc acc agg ctg ctg gag acc ctc tcc       2625
Ala Arg Gly Ala Ser Ser Asp Val Thr Arg Leu Leu Glu Thr Leu Ser           
            805                 810                 815                   

cag atg gag aga tac cag caa cat tcc atg gtg ttt ctg gga cgg cga       2673
Gln Met Glu Arg Tyr Gln Gln His Ser Met Val Phe Leu Gly Arg Arg           
        820                 825                 830                       

tca agg acc aag agc gac ctg agc ctg aag atg tac cag gag gag atc       2721
Ser Arg Thr Lys Ser Asp Leu Ser Leu Lys Met Tyr Gln Glu Glu Ile           
    835                 840                 845                           

cag gag tgg tat gag gag cat gcc agg gag caa gag cag cag cga caa       2769
Gln Glu Trp Tyr Glu Glu His Ala Arg Glu Gln Glu Gln Gln Arg Gln           
850                 855                 860                 865           

ctc agc agc agt gca gcc ccc gcc gcc cag cag ccc cca ggc agc cgc       2817
Leu Ser Ser Ser Ala Ala Pro Ala Ala Gln Gln Pro Pro Gly Ser Arg           
                870                 875                 880               

cag cgc tcc cag acc gtt acc tag cccagcgccc gaaagccgtc tcttctatgc      2871
Gln Arg Ser Gln Thr Val Thr                                               
            885                                                           

aataacacaa tagtattact ctactgcgat gtacggaact gcggtgtgtg tacacatact     2931

cacgtatatg cacatattta tatacaggaa gaaaaaagac agacaagatg gggcttggtt     2991

tataaccacc ttgccctgtc ttccttaact ccagaagcca gtttggtgag gggtgggggt     3051

gcggccacca ggtctgagct cttcctactg tggaaggctc cagaaggccc ttcacaagga     3111

gacccctcac ctggatccag tcgactgcgg ggcttgcccc tcatgtgggc tggcctccat     3171

cggccacgtc caaagctgtc actgctactg cttcaggctc acatcccccc gacctgatgg     3231

cgtgcccgcc ccctctccct gcggcccatg ccacaggttt ctgtgttttg ctttagggac     3291

agaaccactt aggaaggaaa gaactcccgg tctccagggt ggtatttcag tgtctgtgat     3351

aatgtcacgc aacacctctt cggggaccag tgcccaggat ctaatggaag cggaattggg     3411

gcaactgggc ccatgtggcc agagctcagt tagccagtgc cgggcggcca cagattacac     3471

tgaccaatct cctcccttgg ctctgcaagc ctcccaccca gccttctctg gcttaaccct     3531

tgttggcgaa aactcttcca cagtggcctc cttggggacc cagaacccgg aggaaggggc     3591

atgaggcagg aagtggggcc gatgtctgca acccagacca cttcgtggaa tgggctcttg     3651

accaaatccc tttttttgcg atttacccgt tcaagcaaaa caacgttttg gttaactaag     3711

gattgtgcta aagccgatac caggtccttc acacgtgtgc actaggaaca ggagcgaaca     3771

gcacagagag acgctccctg tgggacgcag cagccccgtg gccccggccc agttcccagc     3831

caccctccct ggctctgctc acaccagaga tttccatagc aggagcggtt ggtgcagaag     3891

taggttcaga tgaacctcag ttaacgtcgc cacccctcct cccaccatgg taccctgtag     3951

gagccctgta tgacatctga gcgtggtgga ggtaggaggg ttgccagctg cagtgaccct     4011

gccacagagg cagggtcagt gcagaggtcg ctttggttcc gcttccctgg gccacagaac     4071

ggaacacagc ataggttctg cagcaggagc cgcagtggca ggatggaggg tgcgaagggc     4131

aaggagtgca ctgctgggca ttcctggcca gccccggccc tctggtgcct gcttcctgtg     4191

acttcagaag gcaggtggac agagcctccc tctggccttg tcctcttccc agccacagaa     4251

cgggcagggt ggcacccgac cccaggggag cagtacctgg tcccccaccc cctcctccca     4311

accacctcca aggccaagct gggtcccata gccagcacgg catggttctc cccttccccc     4371

cttcccaggt caggggagtt ggacaagtag caggtgtttg tttttaaagc acagcccttt     4431

gggaaagcaa cacattattg agactcactg tgattccccc gggagtcaga ctggctttgt     4491

cctcttcctc tctggagggc catgggccat cagcaggagc tccacatcga gccccaggcc     4551

agaaccccct ccctttcaca gagagggaac tttattgcac aattgggtgc cttttagctt     4611

ttgtgtgttg aaatgggcgt tttggaagca agggtcaggg gacagcttct aaaggtgtga     4671

gtctctgacc tgagcatctg ggcctcgcct gggcccttct tcctccccag gggtggaaac     4731

gtggaggggc cagcagcacc ccggggtctg cccaggggag tcaaggcccc gaggtggggg     4791

ggcctattcc aggaggagtg ggatctcggc cctgtccaga gcgagttaat gtgtccatct     4851

gcccaaccct gtcctgagaa aggacctggt tttggccagg acctgacaaa tacccaatgg     4911

cagcagtgtc aacagacggg agtccagcca gggtgggtgc ccttgtcatt gaggttaggg     4971

acagctatcc ccaggttatg cctggcccca cccagcaggg agttggggtc cccccacagg     5031

ctgtgagctc tgtgggccct gggatgtgat ctagctcaga tgccctctca tccttgatgt     5091

catagttgag tgcacccaag tggcacccac tggcggccag gggcacagcc tggtggtggt     5151

ggcaatagaa ctgtgcccct cctcagctcc tcgcttcccc tcccacagcc ccagccttac     5211

tccaccatgc ggacaatcat tttgtacgga tcacgggagc aatgctgtac ggttttgtac     5271

actggtggtt tgtttcctag aaaacccatt gtgtctctgg atttctagca cattactaaa     5331

agagcctctg ctttgtaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     5391

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     5451

aaaaaaaaaa aaaaaaaaaa a                                               5472


<210>  338
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  338

Met Glu Ser Cys Tyr Ile Ala Gln Ala Gly Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      


Ser Ser Ser Pro Thr Leu Thr Ser Gln Ser Ala Glu Ile Thr Glu Asp 
            20                  25                  30          


Ala Ser Asn Gly Gly Val Ser Glu Gln His Pro Trp Pro Ser Gly Phe 
        35                  40                  45              


Glu Arg Glu Leu Lys Pro Glu Thr Ile Ser Ser Pro Gly Tyr His Ile 
    50                  55                  60                  


Leu Arg Ala Thr Gly Glu Glu Asn Met Ala Val Ser Leu Asp Asp Asp 
65                  70                  75                  80  


Val Pro Leu Ile Leu Thr Leu Asp Glu Gly Gly Ser Ala Pro Leu Ala 
                85                  90                  95      


Pro Ser Asn Gly Leu Gly Gln Glu Glu Leu Pro Ser Lys Asn Gly Gly 
            100                 105                 110         


Ser Tyr Ala Ile His Asp Ser Gln Ala Pro Ser Leu Ser Ser Gly Gly 
        115                 120                 125             


Glu Ser Ser Pro Ser Ser Pro Ala His Asn Trp Glu Met Asn Tyr Gln 
    130                 135                 140                 


Glu Ala Ala Ile Tyr Leu Gln Glu Gly Glu Asn Asn Asp Lys Phe Phe 
145                 150                 155                 160 


Thr His Pro Lys Asp Ala Lys Ala Leu Ala Ala Tyr Leu Phe Ala His 
                165                 170                 175     


Asn His Leu Phe Tyr Leu Met Glu Leu Ala Thr Ala Leu Leu Leu Leu 
            180                 185                 190         


Leu Leu Ser Leu Cys Glu Ala Pro Ala Val Pro Ala Leu Arg Leu Gly 
        195                 200                 205             


Ile Tyr Val His Ala Thr Leu Glu Leu Phe Ala Leu Met Val Val Val 
    210                 215                 220                 


Phe Glu Leu Cys Met Lys Leu Arg Trp Leu Gly Leu His Thr Phe Ile 
225                 230                 235                 240 


Arg His Lys Arg Thr Met Val Lys Thr Ser Val Leu Val Val Gln Phe 
                245                 250                 255     


Val Glu Ala Ile Val Val Leu Val Arg Gln Met Ser His Val Arg Val 
            260                 265                 270         


Thr Arg Ala Leu Arg Cys Ile Phe Leu Val Asp Cys Arg Tyr Cys Gly 
        275                 280                 285             


Gly Val Arg Arg Asn Leu Arg Gln Ile Phe Gln Ser Leu Pro Pro Phe 
    290                 295                 300                 


Met Asp Ile Leu Leu Leu Leu Leu Phe Phe Met Ile Ile Phe Ala Ile 
305                 310                 315                 320 


Leu Gly Phe Tyr Leu Phe Ser Pro Asn Pro Ser Asp Pro Tyr Phe Ser 
                325                 330                 335     


Thr Leu Glu Asn Ser Ile Val Ser Leu Phe Val Leu Leu Thr Thr Ala 
            340                 345                 350         


Asn Phe Pro Asp Val Met Met Pro Ser Tyr Ser Arg Asn Pro Trp Ser 
        355                 360                 365             


Cys Val Phe Phe Ile Val Tyr Leu Ser Ile Glu Leu Tyr Phe Ile Met 
    370                 375                 380                 


Asn Leu Leu Leu Ala Val Val Phe Asp Thr Phe Asn Asp Ile Glu Lys 
385                 390                 395                 400 


Arg Lys Phe Lys Ser Leu Leu Leu His Lys Arg Thr Ala Ile Gln His 
                405                 410                 415     


Ala Tyr Arg Leu Leu Ile Ser Gln Arg Arg Pro Ala Gly Ile Ser Tyr 
            420                 425                 430         


Arg Gln Phe Glu Gly Leu Met Arg Phe Tyr Lys Pro Arg Met Ser Ala 
        435                 440                 445             


Arg Glu Arg Tyr Leu Thr Phe Lys Ala Leu Asn Gln Asn Asn Thr Pro 
    450                 455                 460                 


Leu Leu Ser Leu Lys Asp Phe Tyr Asp Ile Tyr Glu Val Ala Ala Leu 
465                 470                 475                 480 


Lys Trp Lys Ala Lys Lys Asn Arg Glu His Trp Phe Asp Glu Leu Pro 
                485                 490                 495     


Arg Thr Ala Leu Leu Ile Phe Lys Gly Ile Asn Ile Leu Val Lys Ser 
            500                 505                 510         


Lys Ala Phe Gln Tyr Phe Met Tyr Leu Val Val Ala Val Asn Gly Val 
        515                 520                 525             


Trp Ile Leu Val Glu Thr Phe Met Leu Lys Gly Gly Asn Phe Phe Ser 
    530                 535                 540                 


Lys His Val Pro Trp Ser Tyr Leu Val Phe Leu Thr Ile Tyr Gly Val 
545                 550                 555                 560 


Glu Leu Phe Leu Lys Val Ala Gly Leu Gly Pro Val Glu Tyr Leu Ser 
                565                 570                 575     


Ser Gly Trp Asn Leu Phe Asp Phe Ser Val Thr Val Phe Ala Phe Leu 
            580                 585                 590         


Gly Leu Leu Ala Leu Ala Leu Asn Met Glu Pro Phe Tyr Phe Ile Val 
        595                 600                 605             


Val Leu Arg Pro Leu Gln Leu Leu Arg Leu Phe Lys Leu Lys Glu Arg 
    610                 615                 620                 


Tyr Arg Asn Val Leu Asp Thr Met Phe Glu Leu Leu Pro Arg Met Ala 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Leu Leu Ile Phe Tyr Tyr Ser Phe Ala Ile Val 
                645                 650                 655     


Gly Met Glu Phe Phe Cys Gly Ile Val Phe Pro Asn Cys Cys Asn Thr 
            660                 665                 670         


Ser Thr Val Ala Asp Ala Tyr Arg Trp Arg Asn His Thr Val Gly Asn 
        675                 680                 685             


Arg Thr Val Val Glu Glu Gly Tyr Tyr Tyr Leu Asn Asn Phe Asp Asn 
    690                 695                 700                 


Ile Leu Asn Ser Phe Val Thr Leu Phe Glu Leu Thr Val Val Asn Asn 
705                 710                 715                 720 


Trp Tyr Ile Ile Met Glu Gly Val Thr Ser Gln Thr Ser His Trp Ser 
                725                 730                 735     


Arg Leu Tyr Phe Met Thr Phe Tyr Ile Val Thr Met Val Val Met Thr 
            740                 745                 750         


Ile Ile Val Ala Phe Ile Leu Glu Ala Phe Val Phe Arg Met Asn Tyr 
        755                 760                 765             


Ser Arg Lys Asn Gln Asp Ser Glu Val Asp Gly Gly Ile Thr Leu Glu 
    770                 775                 780                 


Lys Glu Ile Ser Lys Glu Glu Leu Val Ala Val Leu Glu Leu Tyr Arg 
785                 790                 795                 800 


Glu Ala Arg Gly Ala Ser Ser Asp Val Thr Arg Leu Leu Glu Thr Leu 
                805                 810                 815     


Ser Gln Met Glu Arg Tyr Gln Gln His Ser Met Val Phe Leu Gly Arg 
            820                 825                 830         


Arg Ser Arg Thr Lys Ser Asp Leu Ser Leu Lys Met Tyr Gln Glu Glu 
        835                 840                 845             


Ile Gln Glu Trp Tyr Glu Glu His Ala Arg Glu Gln Glu Gln Gln Arg 
    850                 855                 860                 


Gln Leu Ser Ser Ser Ala Ala Pro Ala Ala Gln Gln Pro Pro Gly Ser 
865                 870                 875                 880 


Arg Gln Arg Ser Gln Thr Val Thr 
                885             


<210>  339
<211>  2428
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (12)..(788)

<400>  339
acctggccgc c atg cgc ctc tcc tcc tcc cca cct cgt ggc ccg cag cag        50
             Met Arg Leu Ser Ser Ser Pro Pro Arg Gly Pro Gln Gln          
             1               5                   10                       

ctc tcc agc ttt ggc tcc gtg gac tgg ctc tcc cag agc agc tgc tca         98
Leu Ser Ser Phe Gly Ser Val Asp Trp Leu Ser Gln Ser Ser Cys Ser           
    15                  20                  25                            

ggg ccg acc cac acc ccc agg cct gcc gac ttc tcc ctg ggg agc ctc        146
Gly Pro Thr His Thr Pro Arg Pro Ala Asp Phe Ser Leu Gly Ser Leu           
30                  35                  40                  45            

cct ggc cca ggc cag aca tcc ggc gcc cgg gag ccc cct cag gcc gtc        194
Pro Gly Pro Gly Gln Thr Ser Gly Ala Arg Glu Pro Pro Gln Ala Val           
                50                  55                  60                

agc atc aag gag gcc gcc ggg tcc tca aat ctg cct gcg ccg gag agg        242
Ser Ile Lys Glu Ala Ala Gly Ser Ser Asn Leu Pro Ala Pro Glu Arg           
            65                  70                  75                    

acc atg gcc ggg ttg agt aag gag cca aat acc ttg cgg gcc ccc cgt        290
Thr Met Ala Gly Leu Ser Lys Glu Pro Asn Thr Leu Arg Ala Pro Arg           
        80                  85                  90                        

gtc cgc aca gcc ttc acc atg gag cag gtc cgc acc ttg gag ggc gtc        338
Val Arg Thr Ala Phe Thr Met Glu Gln Val Arg Thr Leu Glu Gly Val           
    95                  100                 105                           

ttc cag cac cac cag tac ctg agc cct ctg gag cgg aag agg ctg gcc        386
Phe Gln His His Gln Tyr Leu Ser Pro Leu Glu Arg Lys Arg Leu Ala           
110                 115                 120                 125           

agg gag atg cag ctc tca gag gtc cag ata aaa acc tgg ttt cag aat        434
Arg Glu Met Gln Leu Ser Glu Val Gln Ile Lys Thr Trp Phe Gln Asn           
                130                 135                 140               

cgc cgc atg aaa cac aaa cgg caa atg cag gac ccc cag ctg cac agc        482
Arg Arg Met Lys His Lys Arg Gln Met Gln Asp Pro Gln Leu His Ser           
            145                 150                 155                   

ccc ttc tcg ggg tct ctc cat gcg ccc cca gct ttc tac tca acg tct        530
Pro Phe Ser Gly Ser Leu His Ala Pro Pro Ala Phe Tyr Ser Thr Ser           
        160                 165                 170                       

tct ggc ctt gcc aat ggc ctg cag ctg ctg tgc cct tgg gca ccc ctg        578
Ser Gly Leu Ala Asn Gly Leu Gln Leu Leu Cys Pro Trp Ala Pro Leu           
    175                 180                 185                           

tcc ggg ccc cag gct ctg atg ctg ccc cct ggc tcc ttc tgg ggt ctc        626
Ser Gly Pro Gln Ala Leu Met Leu Pro Pro Gly Ser Phe Trp Gly Leu           
190                 195                 200                 205           

tgc caa gtg gca caa gag gcc ctg gca tct gcg gga gct tcc tgc tgc        674
Cys Gln Val Ala Gln Glu Ala Leu Ala Ser Ala Gly Ala Ser Cys Cys           
                210                 215                 220               

ggg cag cct ctg gcg tcc cac ccc cct acc cca ggc cgg cct tcg ctg        722
Gly Gln Pro Leu Ala Ser His Pro Pro Thr Pro Gly Arg Pro Ser Leu           
            225                 230                 235                   

gga cca gcc ctg tcc acg ggg ccc cgg ggc ctg tgt gct atg cca cag        770
Gly Pro Ala Leu Ser Thr Gly Pro Arg Gly Leu Cys Ala Met Pro Gln           
        240                 245                 250                       

acg ggg gat gca ttt tga ggaggcacct ctgactccca cactcgcggt               818
Thr Gly Asp Ala Phe                                                       
    255                                                                   

cttgctgatc gcacctggct cctacctgga ggactcagtt gttctgttta catcctggtg      878

gcacctctca ccctgaccca cacaaaggtt ctggagatta ctggagaata tatataaata      938

tatatatgta cgtatatatg taaatacaca tatacgtata tataaatata tatatacata      998

tgtgtgtgta tatatatata tatttttttt tttttttttt tttttgagac ggagtgttgc     1058

tctgtcaccc aggctggagt gcaatgacgc aatctcggct cactgcaacc tccgcctcct     1118

gggttcaagc gattctccag cctcagcctc ccgagtagct gggattacag acacccgcca     1178

ccacgcccgg ctaatttttt ctatttttag tagaaatggg gtttcaccat gttagccagg     1238

ctggtctcaa actcctgacc ctgtgatccg cccgcctcgg cctcccaaag tgctgggatt     1298

acaggcatga gccactgcac ccggccctga gaatatattt attaaagcca cctcttcact     1358

gaaagttacc gaaagagtcg gtttaggaag gaaacgaagg gtcagtgaac agagtcaaat     1418

gcagaagtgg gcttgtcatg ggtagggctt tcggcgtacg ataaaaggat catttgtttt     1478

ttaaaagggg ttggaaaaac tggttttcca gttggaaaca gtaaaggttg taagctttgt     1538

gtgtacaaaa gaaaacaggg aatgcaggtg tgtttatagc gttgtggttc aagtccctct     1598

taacaagaac tccaaagctg gaaagcagga gggaacaaag gtgaacatga aggcgaggat     1658

gctggggccc tgcagtgcgc tctaggctgt gcgtgagccg ggactgtacc cacagcttgc     1718

tgagggctgc tcttcttggg ccagggaaag cagggcagcc gggacctgcg gctgtgcctg     1778

gactgaagct gtcccgcagg tccccaccct ccaacacgtg ctcacctgtc cccctcctcg     1838

cagcagcctc gggacaaaac aatgactcaa ggacagcact tctcgcagaa ggtctggaag     1898

tgcccagaat gggaggcacg gaagcccctc ccggggagga ctcccgcgtt gatggaccgt     1958

tcttggtgca gactcctgac tgcgtgcatg aaacctgaga caagtgcaat tccttccatg     2018

tcgccccaga gtgcccagga ggcaggcagt gcggggtgcc caggcagacg ggttcagcct     2078

gcagaactgg aggcgacctg tgaaacccac ccgggcaccc caacaggaac agaagcgtgg     2138

tcctgcggct gcgtccccag cgagtttcac tttccccttg ctcgtttctc ccttgttgta     2198

agtgtttaca actggcatgt gcttttaaac gtcaggtaag aggggaacag ctgctgtaca     2258

tcgtcctggc gagtgacaat gtgacagaag cctgggcgag gccctcggag ggcagcagct     2318

ggacaggggc tactgggttt ggcctggaca gcactgattt gtggatgtgg atgggggcac     2378

gttgtccgtg ataaaagtac aagtgcccct cacaaaaaaa aaaaaaaaaa                2428


<210>  340
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Arg Leu Ser Ser Ser Pro Pro Arg Gly Pro Gln Gln Leu Ser Ser 
1               5                   10                  15      


Phe Gly Ser Val Asp Trp Leu Ser Gln Ser Ser Cys Ser Gly Pro Thr 
            20                  25                  30          


His Thr Pro Arg Pro Ala Asp Phe Ser Leu Gly Ser Leu Pro Gly Pro 
        35                  40                  45              


Gly Gln Thr Ser Gly Ala Arg Glu Pro Pro Gln Ala Val Ser Ile Lys 
    50                  55                  60                  


Glu Ala Ala Gly Ser Ser Asn Leu Pro Ala Pro Glu Arg Thr Met Ala 
65                  70                  75                  80  


Gly Leu Ser Lys Glu Pro Asn Thr Leu Arg Ala Pro Arg Val Arg Thr 
                85                  90                  95      


Ala Phe Thr Met Glu Gln Val Arg Thr Leu Glu Gly Val Phe Gln His 
            100                 105                 110         


His Gln Tyr Leu Ser Pro Leu Glu Arg Lys Arg Leu Ala Arg Glu Met 
        115                 120                 125             


Gln Leu Ser Glu Val Gln Ile Lys Thr Trp Phe Gln Asn Arg Arg Met 
    130                 135                 140                 


Lys His Lys Arg Gln Met Gln Asp Pro Gln Leu His Ser Pro Phe Ser 
145                 150                 155                 160 


Gly Ser Leu His Ala Pro Pro Ala Phe Tyr Ser Thr Ser Ser Gly Leu 
                165                 170                 175     


Ala Asn Gly Leu Gln Leu Leu Cys Pro Trp Ala Pro Leu Ser Gly Pro 
            180                 185                 190         


Gln Ala Leu Met Leu Pro Pro Gly Ser Phe Trp Gly Leu Cys Gln Val 
        195                 200                 205             


Ala Gln Glu Ala Leu Ala Ser Ala Gly Ala Ser Cys Cys Gly Gln Pro 
    210                 215                 220                 


Leu Ala Ser His Pro Pro Thr Pro Gly Arg Pro Ser Leu Gly Pro Ala 
225                 230                 235                 240 


Leu Ser Thr Gly Pro Arg Gly Leu Cys Ala Met Pro Gln Thr Gly Asp 
                245                 250                 255     


Ala Phe 
        


<210>  341
<211>  7578
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (9)..(3245)

<400>  341
tacgggaa atg ttt ggt gca gca tcc aga atg gac acc act gct gtc tgc        50
         Met Phe Gly Ala Ala Ser Arg Met Asp Thr Thr Ala Val Cys          
         1               5                   10                           

acc ggg gga gtg aca gag agt cga ggg att gtg gat agc ctg cag aag         98
Thr Gly Gly Val Thr Glu Ser Arg Gly Ile Val Asp Ser Leu Gln Lys           
15                  20                  25                  30            

ttt tcc tcg ctc cct gct tac ctc ccc acg aac ttg cac atc tcc aat        146
Phe Ser Ser Leu Pro Ala Tyr Leu Pro Thr Asn Leu His Ile Ser Asn           
                35                  40                  45                

gca gag gag tcc ttt ttc ctt aaa gaa gcc aac caa gac ctc aca agg        194
Ala Glu Glu Ser Phe Phe Leu Lys Glu Ala Asn Gln Asp Leu Thr Arg           
            50                  55                  60                    

aac tcc agt ctg cag gcc cgg gtg gag cca ttc ttc atc tac cga gcc        242
Asn Ser Ser Leu Gln Ala Arg Val Glu Pro Phe Phe Ile Tyr Arg Ala           
        65                  70                  75                        

agg aca ccc cct att atc aat gcc agc tat ggc cca ttt tca gtg gag        290
Arg Thr Pro Pro Ile Ile Asn Ala Ser Tyr Gly Pro Phe Ser Val Glu           
    80                  85                  90                            

aag ata atc ccc cag gag ctc ctg ttg aca tct aca gcc ttt gga aac        338
Lys Ile Ile Pro Gln Glu Leu Leu Leu Thr Ser Thr Ala Phe Gly Asn           
95                  100                 105                 110           

atg gac aaa ttt ccc ttc aac tgg aaa ttg aaa tcc cac atc ctt gac        386
Met Asp Lys Phe Pro Phe Asn Trp Lys Leu Lys Ser His Ile Leu Asp           
                115                 120                 125               

agc tcc atc tac tcc aac aga ccc aaa gtg cag acc ttg ttt tat gtc        434
Ser Ser Ile Tyr Ser Asn Arg Pro Lys Val Gln Thr Leu Phe Tyr Val           
            130                 135                 140                   

act ggc atg ggc tgg gat gac agt gac ctt acg gaa gat cta ccc tgt        482
Thr Gly Met Gly Trp Asp Asp Ser Asp Leu Thr Glu Asp Leu Pro Cys           
        145                 150                 155                       

gtc aag atg ttt gct ttc cct gag gcc agg gaa gtg gca gcc agc tgt        530
Val Lys Met Phe Ala Phe Pro Glu Ala Arg Glu Val Ala Ala Ser Cys           
    160                 165                 170                           

cgg ctg caa ggg gcc cca ggg ctg tgt gtg gct gag ctg gag ctg ctg        578
Arg Leu Gln Gly Ala Pro Gly Leu Cys Val Ala Glu Leu Glu Leu Leu           
175                 180                 185                 190           

ccc gag tgg ttc agc tca ggc ctg gac ctg gaa cca gag gag gag atc        626
Pro Glu Trp Phe Ser Ser Gly Leu Asp Leu Glu Pro Glu Glu Glu Ile           
                195                 200                 205               

cca gcc ctg ctc ggg ggc acc acg atg gag ctc ttc ttc acg ctc tac        674
Pro Ala Leu Leu Gly Gly Thr Thr Met Glu Leu Phe Phe Thr Leu Tyr           
            210                 215                 220                   

cca gct gac aag gct ggc cag tgt cct ctg gag gag gaa ggc aag tgg        722
Pro Ala Asp Lys Ala Gly Gln Cys Pro Leu Glu Glu Glu Gly Lys Trp           
        225                 230                 235                       

gag aac aat atc cac tcg ggc ctg gag agc ccc cag caa gcg ttt cca        770
Glu Asn Asn Ile His Ser Gly Leu Glu Ser Pro Gln Gln Ala Phe Pro           
    240                 245                 250                           

gcc cga gag agg att ggg agt gtg gtg gtc tac cca acc caa gat gat        818
Ala Arg Glu Arg Ile Gly Ser Val Val Val Tyr Pro Thr Gln Asp Asp           
255                 260                 265                 270           

ctg aag tgg tcc ctg gtg agc ttg gac gag aat gtg gtc atc tcg gta        866
Leu Lys Trp Ser Leu Val Ser Leu Asp Glu Asn Val Val Ile Ser Val           
                275                 280                 285               

cct ctg aat cta gtc cgg gaa ggg gac acg gcc acc ttt ttg gtc tct        914
Pro Leu Asn Leu Val Arg Glu Gly Asp Thr Ala Thr Phe Leu Val Ser           
            290                 295                 300                   

ctg acc agt agc tct gtg gca gac cag ttc act ctt aga att aag gcg        962
Leu Thr Ser Ser Ser Val Ala Asp Gln Phe Thr Leu Arg Ile Lys Ala           
        305                 310                 315                       

gca gca ggt gtg aag ata acg gca gtg aga gtc agc agt gag gac caa       1010
Ala Ala Gly Val Lys Ile Thr Ala Val Arg Val Ser Ser Glu Asp Gln           
    320                 325                 330                           

tgg gca gtc cag gag gaa att gat aat ggc agc act cag acg tcg gcc       1058
Trp Ala Val Gln Glu Glu Ile Asp Asn Gly Ser Thr Gln Thr Ser Ala           
335                 340                 345                 350           

acc ctc acc tgc atg ggc cat cgc ccg gac acg cag agc agg gta aat       1106
Thr Leu Thr Cys Met Gly His Arg Pro Asp Thr Gln Ser Arg Val Asn           
                355                 360                 365               

gga tcc ttc tat gag atc ttg caa gtg gac ttt gga att gat aat agc       1154
Gly Ser Phe Tyr Glu Ile Leu Gln Val Asp Phe Gly Ile Asp Asn Ser           
            370                 375                 380                   

agt gac ctg gct ggg gcc cag cag att acc tgg cag gtg gag tac ccg       1202
Ser Asp Leu Ala Gly Ala Gln Gln Ile Thr Trp Gln Val Glu Tyr Pro           
        385                 390                 395                       

att gag gac tcc atg agt gag ctg gtc gtc tcc gag atc ttc gtc agc       1250
Ile Glu Asp Ser Met Ser Glu Leu Val Val Ser Glu Ile Phe Val Ser           
    400                 405                 410                           

cag aca acc ttc gtg ggc atc gtc cct ctt gcc atg gac acc gag gtt       1298
Gln Thr Thr Phe Val Gly Ile Val Pro Leu Ala Met Asp Thr Glu Val           
415                 420                 425                 430           

ttg aac act gcc att ctc act gga aag cct gtt tca gtt cct gtc aaa       1346
Leu Asn Thr Ala Ile Leu Thr Gly Lys Pro Val Ser Val Pro Val Lys           
                435                 440                 445               

gtc gtg ggg gtc cag gag gat ggt tct gtg gtc gat gtg tct gag tct       1394
Val Val Gly Val Gln Glu Asp Gly Ser Val Val Asp Val Ser Glu Ser           
            450                 455                 460                   

gtg gaa tgc aag tct gcc gat gaa gat gtc att aag gtt tcc aac aac       1442
Val Glu Cys Lys Ser Ala Asp Glu Asp Val Ile Lys Val Ser Asn Asn           
        465                 470                 475                       

tgt gat tcc att ttt gtg aat ggg aag gaa atg aag agc aaa gtg gac       1490
Cys Asp Ser Ile Phe Val Asn Gly Lys Glu Met Lys Ser Lys Val Asp           
    480                 485                 490                           

acg att gtg aac ttc acc cac cag cac ttc acc tcc cag ttc gag gtc       1538
Thr Ile Val Asn Phe Thr His Gln His Phe Thr Ser Gln Phe Glu Val           
495                 500                 505                 510           

act gtc tgg gca ccc agg ctc ccc ctg cag att gag atc tca gac acc       1586
Thr Val Trp Ala Pro Arg Leu Pro Leu Gln Ile Glu Ile Ser Asp Thr           
                515                 520                 525               

gag ctg agc cag atc aag ggc tgg agg atc ccg gtt gct gcc aac aga       1634
Glu Leu Ser Gln Ile Lys Gly Trp Arg Ile Pro Val Ala Ala Asn Arg           
            530                 535                 540                   

agg cct acc cgg gaa agc gat gac gag gac gat gag gag aag aag gga       1682
Arg Pro Thr Arg Glu Ser Asp Asp Glu Asp Asp Glu Glu Lys Lys Gly           
        545                 550                 555                       

cga ggc tgc tcc ctg cag tac cag cac gcc aca gtg cgt gtc ctc acc       1730
Arg Gly Cys Ser Leu Gln Tyr Gln His Ala Thr Val Arg Val Leu Thr           
    560                 565                 570                           

cag ttt gtg gcc gag tca cct gac tta ggg cag ctg acc tac atg ctg       1778
Gln Phe Val Ala Glu Ser Pro Asp Leu Gly Gln Leu Thr Tyr Met Leu           
575                 580                 585                 590           

ggc ccc gac tgg cag ttt gac atc act gac ctt gtg acc gag ttc atg       1826
Gly Pro Asp Trp Gln Phe Asp Ile Thr Asp Leu Val Thr Glu Phe Met           
                595                 600                 605               

aag gtg gag gag ccg aaa atc gct cag tta cag gac ggc agg acc ctg       1874
Lys Val Glu Glu Pro Lys Ile Ala Gln Leu Gln Asp Gly Arg Thr Leu           
            610                 615                 620                   

gct ggt cgg gag ccg gga ata acc acg gtg cag gtc ctc tcg ccg ttg       1922
Ala Gly Arg Glu Pro Gly Ile Thr Thr Val Gln Val Leu Ser Pro Leu           
        625                 630                 635                       

tct gac tcc atc ctg gct gag aag acg gtg att gtc ctg gat gac cga       1970
Ser Asp Ser Ile Leu Ala Glu Lys Thr Val Ile Val Leu Asp Asp Arg           
    640                 645                 650                           

gtc acc atc gcg gag ctg gga gtg cag ctc gta gct ggc atg tct ctc       2018
Val Thr Ile Ala Glu Leu Gly Val Gln Leu Val Ala Gly Met Ser Leu           
655                 660                 665                 670           

tcc ctg cag cca cac cga gca gac aaa agg gcc atc gtc tcc aca gct       2066
Ser Leu Gln Pro His Arg Ala Asp Lys Arg Ala Ile Val Ser Thr Ala           
                675                 680                 685               

gct gcc ctg gat gtt ctt cag tcc cca cag cag gaa gca ata gta agt       2114
Ala Ala Leu Asp Val Leu Gln Ser Pro Gln Gln Glu Ala Ile Val Ser           
            690                 695                 700                   

tct tgg att ttg ttc agt gat ggt tcg gtg aca cct tta gac att tac       2162
Ser Trp Ile Leu Phe Ser Asp Gly Ser Val Thr Pro Leu Asp Ile Tyr           
        705                 710                 715                       

gat cct aag gat tat tct gtt act gtc tca tca ttg gat gaa atg gtg       2210
Asp Pro Lys Asp Tyr Ser Val Thr Val Ser Ser Leu Asp Glu Met Val           
    720                 725                 730                           

gtg tct gtc cag gca aac ctt gag tcc aaa tgg cca att gtg gtt gca       2258
Val Ser Val Gln Ala Asn Leu Glu Ser Lys Trp Pro Ile Val Val Ala           
735                 740                 745                 750           

gag ggt gaa gga caa ggg cct ttg att aag tta gaa atg atg ata agt       2306
Glu Gly Glu Gly Gln Gly Pro Leu Ile Lys Leu Glu Met Met Ile Ser           
                755                 760                 765               

gaa cct tgt cag aag acc aag agg aag agt gtt ctt gcc gtg ggt aaa       2354
Glu Pro Cys Gln Lys Thr Lys Arg Lys Ser Val Leu Ala Val Gly Lys           
            770                 775                 780                   

gga aat gtc aag gtc aaa ttc gaa cca agt agt gat gag cac caa gga       2402
Gly Asn Val Lys Val Lys Phe Glu Pro Ser Ser Asp Glu His Gln Gly           
        785                 790                 795                       

ggc agc aat gat att gag ggc ata aat cgg gaa tat aaa gac cac ctc       2450
Gly Ser Asn Asp Ile Glu Gly Ile Asn Arg Glu Tyr Lys Asp His Leu           
    800                 805                 810                           

agt aat tcc ata gag cgc gaa gga aac cag gag aga gca gtc cag gaa       2498
Ser Asn Ser Ile Glu Arg Glu Gly Asn Gln Glu Arg Ala Val Gln Glu           
815                 820                 825                 830           

tgg ttc cac cgt ggc aca cct gtt ggc caa gag gaa agt acc aac aaa       2546
Trp Phe His Arg Gly Thr Pro Val Gly Gln Glu Glu Ser Thr Asn Lys           
                835                 840                 845               

agc aca acc ccc cag tct ccc atg gaa ggg aag aat aag tta ctc aaa       2594
Ser Thr Thr Pro Gln Ser Pro Met Glu Gly Lys Asn Lys Leu Leu Lys           
            850                 855                 860                   

agt ggt ggt cca gat gcc ttt aca agc ttc ccc act caa ggg aag tca       2642
Ser Gly Gly Pro Asp Ala Phe Thr Ser Phe Pro Thr Gln Gly Lys Ser           
        865                 870                 875                       

ccg gac ccc aat aat cct agt gac ctc aca gtg acc tca agg ggg cta       2690
Pro Asp Pro Asn Asn Pro Ser Asp Leu Thr Val Thr Ser Arg Gly Leu           
    880                 885                 890                           

acg gac ttg gag att ggc atg tat gcc ttg ctc tgc gtc ttc tgt ctg       2738
Thr Asp Leu Glu Ile Gly Met Tyr Ala Leu Leu Cys Val Phe Cys Leu           
895                 900                 905                 910           

gcc att ctg gtc ttc ttg atc aac tgc gtg gcg ttt gcc tgg aaa tac       2786
Ala Ile Leu Val Phe Leu Ile Asn Cys Val Ala Phe Ala Trp Lys Tyr           
                915                 920                 925               

aga cac aaa agg ttt gct gtg agt gag cag ggc aac atc ccc cat tcc       2834
Arg His Lys Arg Phe Ala Val Ser Glu Gln Gly Asn Ile Pro His Ser           
            930                 935                 940                   

cac gac tgg gtc tgg ctt ggg aat gaa gtg gaa ctt ttg gag aac cct       2882
His Asp Trp Val Trp Leu Gly Asn Glu Val Glu Leu Leu Glu Asn Pro           
        945                 950                 955                       

gtt gac att aca ctc cca tca gag gag tgc aca acc atg ata gac agg       2930
Val Asp Ile Thr Leu Pro Ser Glu Glu Cys Thr Thr Met Ile Asp Arg           
    960                 965                 970                           

ggc ctg cag ttc gag gag agg aac ttc ctt ctg aat ggc agt tcc cag       2978
Gly Leu Gln Phe Glu Glu Arg Asn Phe Leu Leu Asn Gly Ser Ser Gln           
975                 980                 985                 990           

aag act ttt cat agt caa cta ctc aga ccc  tct gac tat gtc tat  gag     3026
Lys Thr Phe His Ser Gln Leu Leu Arg Pro  Ser Asp Tyr Val Tyr  Glu         
                995                 1000                 1005             

aaa gaa att aaa  aat gaa cct atg aat  tct tcg ggc cca aag  agg        3071
Lys Glu Ile Lys  Asn Glu Pro Met Asn  Ser Ser Gly Pro Lys  Arg            
            1010                 1015                 1020                

aag aga gtc aag  ttc act tcc tac acc  acc atc ctc cca gag  gac        3116
Lys Arg Val Lys  Phe Thr Ser Tyr Thr  Thr Ile Leu Pro Glu  Asp            
            1025                 1030                 1035                

ggc ggc cca tac  acc aac tcc atc ctg  ttt gac agc gat gat  aac        3161
Gly Gly Pro Tyr  Thr Asn Ser Ile Leu  Phe Asp Ser Asp Asp  Asn            
            1040                 1045                 1050                

atc aag tgg gtc  tgc caa gat atg ggg  ctg ggg gat tca cag  gac        3206
Ile Lys Trp Val  Cys Gln Asp Met Gly  Leu Gly Asp Ser Gln  Asp            
            1055                 1060                 1065                

ttt aga gac tat  atg gaa agt ctg caa  gac cag atg taa actcctttct      3255
Phe Arg Asp Tyr  Met Glu Ser Leu Gln  Asp Gln Met                         
            1070                 1075                                     

tatgtttgta ttcaccttta tgccttctgt tttttgaatg ctggagcagt gagtttgatc     3315

agcaataggg gatgatttaa caaagtttga tttgtggagg tctggtggga ttcatttcta     3375

agcaggtaaa agaggtttgg agagctatag aagctgggtt ttaagtttgg aaatgcctct     3435

aaaacagcca catgtgggga ctggagaaat tctaagacaa cagttttatg gactgcctgg     3495

tacgagctca gtgcaaatgt attaaacctg accccacaga cattgttagt catctcgtga     3555

caaatggcca tgtggaatta gaaaagattt gggtgttgat ttttctattt ctagaccttt     3615

taaagcacag tggacactta ttgccccttg gcctgagttt agacatacat gaaagatgac     3675

tgaatgtagc tatcctgatt tgtcatgagc gctgctcatt atttttatat acatttgcac     3735

ctgcacctgt tcctttgacc tctggaattc tttttgaaac atgaagagaa gaaatttcag     3795

tcttttcctt gagctctgtt tgatttacac atgagttttc ttccctggga tttgccatgc     3855

catgttattt cctgggtctc catgcaggat gtcaggtttt tccagttttc tgcacttcat     3915

catctaggga tggtatccaa gaagcttatt ctcactttgt tttttccttc cttttgttgt     3975

tgaactttct tgtataacac tgggacaaag ggttttactt aaaatgttaa tatacagtga     4035

gggagggcca tctctttact gttttctatg tgaagtttca aacatttgga aaaaagttgt     4095

caatcacaaa catttatttt tattctctgc ttgttgaaaa ctcatgggga actcctggag     4155

tgcatttctg agggtaaaaa ggccccaaca tagctgtatt tatacaagtg ctttgtggcc     4215

aacacaattt actatccaaa ctgaagtctt aaagtagaat tgacctacac agaaaggaaa     4275

ttgcctaggc aatagatgca gattacactt tccattttac cagaacaaaa gttttttttt     4335

ttttaaataa gtagaatgac agttcaagtt agcaatatat agaaatccat ccatacaatg     4395

accaaaataa ataaataaat aaaactcaat catgactttg gcagagataa aacattgaca     4455

agggtgtgca tttgtggaga gaagcagtgg gtttcccccc aaaatccata caaataaatg     4515

actattccag aactcaagaa gcagctatta tagaaaaaaa aattaaaaac cacagctatt     4575

gaaaaattaa aacggcaaga gaaaaaaaga aacaactcct gcataatgtt taaataaaaa     4635

tgttatttta atagcatcat gaatggtctt aaggcaaaaa tttcagatta gcaaaatgtg     4695

atgacatatt tattaagatt gtattattgg aaatgtagac actggactag tatgcctcat     4755

tatgagcttt actgagccat ttgcatctct aagaaatatg attttaaagg cccaaagtag     4815

gaaggatctg cagggggtca cctgaagcag tgccctgact ccaaatggct gataactgag     4875

ctaatccaag gagaggcgtt cagttgttct cttattatag atttccttgg gtgggaacat     4935

gacaaccccg cctcctctag ccatgacgtg gcagccaaaa agttcttcct gtatctctgg     4995

cccacaggac tgtagtgtgt ttgggaacag tgctgaaatt gcaagtgatg taggcctgac     5055

ctccagagcc cagcgttcag ttagttgtat aaaatggggc ttaggaaccg aagctgatga     5115

agttccaaaa gtagttcagt ttgatgggat aaggaagcaa ggagagccag gcattagctg     5175

caaaaggagc ttgcagagag atggctgaca ctttatggga agattcctca gtcagccaaa     5235

agcttttcaa agagtttggt gcagaggtag ctcagagcca accatccagg accgaagaaa     5295

gctcatgtgc tgattgacac atagctatcc aggtgagtcg gctccttcta tgaggctttt     5355

caatcgtctc tccctttgga tctctggcat tccagaaaga ctgggaattc atttctgaaa     5415

atgatgaacc tccgctgaaa cggggaggaa atctcttaca cacatacagc agggtcctgc     5475

ccactggtaa agtgagacgt tgggtagggg gtgtaactgg ggaggaggtg aaggaaatta     5535

tccctgccat ggggagtgtt attcaggaac ataaaaatta gagcattccc tctgatggca     5595

gtgcttgacg gggtgcaggg aacaaactgg ggagcgttca aacatgccag tggtttctca     5655

gcagggctgg aaactggcca cagtcctgaa gatgcttctt gtgacaactt agagtcactg     5715

ggagtcacac agctcctgtg tagccgcctt tgctcctctg tgttaaaacc cagtcagttc     5775

aaaataacaa tcaaatggaa ggccatgggg gaagggttcc ttccaccata taacccacac     5835

ccagatgtat ataaacgcat atacatacat atacccgtgt gtgtgtgtgt gtgtgtgtgt     5895

gtgtgtgtga atactgaaga gccagacaac aaactattta gtaagaatca acagtgactg     5955

tcaattgttc tcagatttgg catggatact atttctcatg aaataatgtc attaaagtat     6015

ttcctcctct aaatatttcc tgaagatcat aaaccatggg ttatagcacc ttgttttcca     6075

gctagtcaat atacaactat taggtgctgt gccccaaaat atctaaaatg ggggtaaaga     6135

tataaactat taagccatga aatctaattt tctggggacc atgcatttgc ctggattttc     6195

caggatttta tggctgatag acccaaatta ttagtcttga taaacaacct gaaccaaaca     6255

tttataaagt cccttcctct cccatgggaa tggaatgctc agactcctgc tgagggagac     6315

accagcaagc ctcttgagaa ggcaccagac agtgaactct gtggtcacat gaagggaggt     6375

tcagatgcta gacgaccagc gtatgacctg gaaccattga ggattgcaac cgctgcctcc     6435

agggtccaga tgtgctgcag tagagggcag agcacaggaa tcaagaagca gctgccacac     6495

caaagaactg atgcttaaac acacaggtgt gttgcatttg agagaaggca agaagaaaag     6555

acaatagaag gttaccctgg aaaaacaaca cctagcaaac ctcagaatac tccatgtgtc     6615

ccaagagaag gaataattgt ctttctagct gttatatatt gcacactggc caggataaat     6675

tcccagacta taataatcct gactatgtag acggaagttt ctatttataa agtcatgcag     6735

ggggaaagtt gattaatttt tgtcccattg ccacatctgt agactaagta atttttaact     6795

tgctaacttt tagaatgtcc acctttgtgc attttggtag cattcttgtt tcattatttt     6855

agaaaggggt cttcccatta ctgggatgtc ggggccctgt cagagaacta ttattaaggc     6915

tctgtgaggg aactgttcag tctcacagca aggaccacag agcgtggttt catctgaacc     6975

ctacaagtca gggacaccag tgtgttttct actcgagtta cctaaaaatg gtctcaattt     7035

tccatttcat tctctgtaaa tgacacaata gatggtttat agactcagca gccctcacct     7095

tttattaaaa ttatatatgt gtgatgtaat gcatatcacc tgtcatgtaa agggacggta     7155

tggatggtgg aaaagttatg ctaaaatatg gattgcagat atttttgtat gtaatatagg     7215

caatataatg aaacaccgag ttttttaaag tgaaagcatg caaaatcgta gcttttaaat     7275

gtacagacat cccactcaaa aatatctaaa ctgatagtgg gaaaaacatt tgagacctag     7335

taacatcatg aaatgcactg aatttggaat tctggcctag aaaggctgtg gcttatgttg     7395

ggattgatga tggaatctgc cagaacattt tcatcttatt cttcttgact tttggatttt     7455

tttcttttct ttttttctgg aaatatttcg gaaataaagt gacttcattt ttcagcataa     7515

aagtatattc taaccacagg gtaacacatc gtttttaaca tgaaaataaa catttaaaca     7575

ttc                                                                   7578


<210>  342
<211>  1078
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Phe Gly Ala Ala Ser Arg Met Asp Thr Thr Ala Val Cys Thr Gly 
1               5                   10                  15      


Gly Val Thr Glu Ser Arg Gly Ile Val Asp Ser Leu Gln Lys Phe Ser 
            20                  25                  30          


Ser Leu Pro Ala Tyr Leu Pro Thr Asn Leu His Ile Ser Asn Ala Glu 
        35                  40                  45              


Glu Ser Phe Phe Leu Lys Glu Ala Asn Gln Asp Leu Thr Arg Asn Ser 
    50                  55                  60                  


Ser Leu Gln Ala Arg Val Glu Pro Phe Phe Ile Tyr Arg Ala Arg Thr 
65                  70                  75                  80  


Pro Pro Ile Ile Asn Ala Ser Tyr Gly Pro Phe Ser Val Glu Lys Ile 
                85                  90                  95      


Ile Pro Gln Glu Leu Leu Leu Thr Ser Thr Ala Phe Gly Asn Met Asp 
            100                 105                 110         


Lys Phe Pro Phe Asn Trp Lys Leu Lys Ser His Ile Leu Asp Ser Ser 
        115                 120                 125             


Ile Tyr Ser Asn Arg Pro Lys Val Gln Thr Leu Phe Tyr Val Thr Gly 
    130                 135                 140                 


Met Gly Trp Asp Asp Ser Asp Leu Thr Glu Asp Leu Pro Cys Val Lys 
145                 150                 155                 160 


Met Phe Ala Phe Pro Glu Ala Arg Glu Val Ala Ala Ser Cys Arg Leu 
                165                 170                 175     


Gln Gly Ala Pro Gly Leu Cys Val Ala Glu Leu Glu Leu Leu Pro Glu 
            180                 185                 190         


Trp Phe Ser Ser Gly Leu Asp Leu Glu Pro Glu Glu Glu Ile Pro Ala 
        195                 200                 205             


Leu Leu Gly Gly Thr Thr Met Glu Leu Phe Phe Thr Leu Tyr Pro Ala 
    210                 215                 220                 


Asp Lys Ala Gly Gln Cys Pro Leu Glu Glu Glu Gly Lys Trp Glu Asn 
225                 230                 235                 240 


Asn Ile His Ser Gly Leu Glu Ser Pro Gln Gln Ala Phe Pro Ala Arg 
                245                 250                 255     


Glu Arg Ile Gly Ser Val Val Val Tyr Pro Thr Gln Asp Asp Leu Lys 
            260                 265                 270         


Trp Ser Leu Val Ser Leu Asp Glu Asn Val Val Ile Ser Val Pro Leu 
        275                 280                 285             


Asn Leu Val Arg Glu Gly Asp Thr Ala Thr Phe Leu Val Ser Leu Thr 
    290                 295                 300                 


Ser Ser Ser Val Ala Asp Gln Phe Thr Leu Arg Ile Lys Ala Ala Ala 
305                 310                 315                 320 


Gly Val Lys Ile Thr Ala Val Arg Val Ser Ser Glu Asp Gln Trp Ala 
                325                 330                 335     


Val Gln Glu Glu Ile Asp Asn Gly Ser Thr Gln Thr Ser Ala Thr Leu 
            340                 345                 350         


Thr Cys Met Gly His Arg Pro Asp Thr Gln Ser Arg Val Asn Gly Ser 
        355                 360                 365             


Phe Tyr Glu Ile Leu Gln Val Asp Phe Gly Ile Asp Asn Ser Ser Asp 
    370                 375                 380                 


Leu Ala Gly Ala Gln Gln Ile Thr Trp Gln Val Glu Tyr Pro Ile Glu 
385                 390                 395                 400 


Asp Ser Met Ser Glu Leu Val Val Ser Glu Ile Phe Val Ser Gln Thr 
                405                 410                 415     


Thr Phe Val Gly Ile Val Pro Leu Ala Met Asp Thr Glu Val Leu Asn 
            420                 425                 430         


Thr Ala Ile Leu Thr Gly Lys Pro Val Ser Val Pro Val Lys Val Val 
        435                 440                 445             


Gly Val Gln Glu Asp Gly Ser Val Val Asp Val Ser Glu Ser Val Glu 
    450                 455                 460                 


Cys Lys Ser Ala Asp Glu Asp Val Ile Lys Val Ser Asn Asn Cys Asp 
465                 470                 475                 480 


Ser Ile Phe Val Asn Gly Lys Glu Met Lys Ser Lys Val Asp Thr Ile 
                485                 490                 495     


Val Asn Phe Thr His Gln His Phe Thr Ser Gln Phe Glu Val Thr Val 
            500                 505                 510         


Trp Ala Pro Arg Leu Pro Leu Gln Ile Glu Ile Ser Asp Thr Glu Leu 
        515                 520                 525             


Ser Gln Ile Lys Gly Trp Arg Ile Pro Val Ala Ala Asn Arg Arg Pro 
    530                 535                 540                 


Thr Arg Glu Ser Asp Asp Glu Asp Asp Glu Glu Lys Lys Gly Arg Gly 
545                 550                 555                 560 


Cys Ser Leu Gln Tyr Gln His Ala Thr Val Arg Val Leu Thr Gln Phe 
                565                 570                 575     


Val Ala Glu Ser Pro Asp Leu Gly Gln Leu Thr Tyr Met Leu Gly Pro 
            580                 585                 590         


Asp Trp Gln Phe Asp Ile Thr Asp Leu Val Thr Glu Phe Met Lys Val 
        595                 600                 605             


Glu Glu Pro Lys Ile Ala Gln Leu Gln Asp Gly Arg Thr Leu Ala Gly 
    610                 615                 620                 


Arg Glu Pro Gly Ile Thr Thr Val Gln Val Leu Ser Pro Leu Ser Asp 
625                 630                 635                 640 


Ser Ile Leu Ala Glu Lys Thr Val Ile Val Leu Asp Asp Arg Val Thr 
                645                 650                 655     


Ile Ala Glu Leu Gly Val Gln Leu Val Ala Gly Met Ser Leu Ser Leu 
            660                 665                 670         


Gln Pro His Arg Ala Asp Lys Arg Ala Ile Val Ser Thr Ala Ala Ala 
        675                 680                 685             


Leu Asp Val Leu Gln Ser Pro Gln Gln Glu Ala Ile Val Ser Ser Trp 
    690                 695                 700                 


Ile Leu Phe Ser Asp Gly Ser Val Thr Pro Leu Asp Ile Tyr Asp Pro 
705                 710                 715                 720 


Lys Asp Tyr Ser Val Thr Val Ser Ser Leu Asp Glu Met Val Val Ser 
                725                 730                 735     


Val Gln Ala Asn Leu Glu Ser Lys Trp Pro Ile Val Val Ala Glu Gly 
            740                 745                 750         


Glu Gly Gln Gly Pro Leu Ile Lys Leu Glu Met Met Ile Ser Glu Pro 
        755                 760                 765             


Cys Gln Lys Thr Lys Arg Lys Ser Val Leu Ala Val Gly Lys Gly Asn 
    770                 775                 780                 


Val Lys Val Lys Phe Glu Pro Ser Ser Asp Glu His Gln Gly Gly Ser 
785                 790                 795                 800 


Asn Asp Ile Glu Gly Ile Asn Arg Glu Tyr Lys Asp His Leu Ser Asn 
                805                 810                 815     


Ser Ile Glu Arg Glu Gly Asn Gln Glu Arg Ala Val Gln Glu Trp Phe 
            820                 825                 830         


His Arg Gly Thr Pro Val Gly Gln Glu Glu Ser Thr Asn Lys Ser Thr 
        835                 840                 845             


Thr Pro Gln Ser Pro Met Glu Gly Lys Asn Lys Leu Leu Lys Ser Gly 
    850                 855                 860                 


Gly Pro Asp Ala Phe Thr Ser Phe Pro Thr Gln Gly Lys Ser Pro Asp 
865                 870                 875                 880 


Pro Asn Asn Pro Ser Asp Leu Thr Val Thr Ser Arg Gly Leu Thr Asp 
                885                 890                 895     


Leu Glu Ile Gly Met Tyr Ala Leu Leu Cys Val Phe Cys Leu Ala Ile 
            900                 905                 910         


Leu Val Phe Leu Ile Asn Cys Val Ala Phe Ala Trp Lys Tyr Arg His 
        915                 920                 925             


Lys Arg Phe Ala Val Ser Glu Gln Gly Asn Ile Pro His Ser His Asp 
    930                 935                 940                 


Trp Val Trp Leu Gly Asn Glu Val Glu Leu Leu Glu Asn Pro Val Asp 
945                 950                 955                 960 


Ile Thr Leu Pro Ser Glu Glu Cys Thr Thr Met Ile Asp Arg Gly Leu 
                965                 970                 975     


Gln Phe Glu Glu Arg Asn Phe Leu Leu Asn Gly Ser Ser Gln Lys Thr 
            980                 985                 990         


Phe His Ser Gln Leu Leu Arg Pro  Ser Asp Tyr Val Tyr  Glu Lys Glu 
        995                 1000                 1005             


Ile Lys  Asn Glu Pro Met Asn  Ser Ser Gly Pro Lys  Arg Lys Arg 
    1010                 1015                 1020             


Val Lys  Phe Thr Ser Tyr Thr  Thr Ile Leu Pro Glu  Asp Gly Gly 
    1025                 1030                 1035             


Pro Tyr  Thr Asn Ser Ile Leu  Phe Asp Ser Asp Asp  Asn Ile Lys 
    1040                 1045                 1050             


Trp Val  Cys Gln Asp Met Gly  Leu Gly Asp Ser Gln  Asp Phe Arg 
    1055                 1060                 1065             


Asp Tyr  Met Glu Ser Leu Gln  Asp Gln Met 
    1070                 1075             


<210>  343
<211>  1613
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (21)..(833)

<400>  343
gaggagcagg gccgggcgcc atg gca ccg tgg ggc aag cgg ctg gct ggc gtg       53
                      Met Ala Pro Trp Gly Lys Arg Leu Ala Gly Val         
                      1               5                   10              

cgc ggg gtg ctg ctt gac atc tcg ggc gtg ctg tac gac agc ggc gcg        101
Arg Gly Val Leu Leu Asp Ile Ser Gly Val Leu Tyr Asp Ser Gly Ala           
            15                  20                  25                    

ggc ggc ggc acg gcc atc gcc ggc tcg gtg gag gcg gtg gcc aga ctg        149
Gly Gly Gly Thr Ala Ile Ala Gly Ser Val Glu Ala Val Ala Arg Leu           
        30                  35                  40                        

aag cgt tcc cgg ctg aag gtg agg ttc tgc acc aac gag tcg cag aag        197
Lys Arg Ser Arg Leu Lys Val Arg Phe Cys Thr Asn Glu Ser Gln Lys           
    45                  50                  55                            

tcc cgg gca gag ctg gtg ggg cag ctt cag agg ctg gga ttt gac atc        245
Ser Arg Ala Glu Leu Val Gly Gln Leu Gln Arg Leu Gly Phe Asp Ile           
60                  65                  70                  75            

tct gag cag gag gtg acc gcc ccg gca cca gct gcc tgc cag atc ctg        293
Ser Glu Gln Glu Val Thr Ala Pro Ala Pro Ala Ala Cys Gln Ile Leu           
                80                  85                  90                

aag gag cga ggc ctg cga cca tac ctg ctc atc cat gac gga gtc cgc        341
Lys Glu Arg Gly Leu Arg Pro Tyr Leu Leu Ile His Asp Gly Val Arg           
            95                  100                 105                   

tca gaa ttt gat cag atc gac aca tcc aac cca aac tgt gtg gta att        389
Ser Glu Phe Asp Gln Ile Asp Thr Ser Asn Pro Asn Cys Val Val Ile           
        110                 115                 120                       

gca gac gca gga gaa agc ttt tct tat caa aac atg aat aac gcc ttc        437
Ala Asp Ala Gly Glu Ser Phe Ser Tyr Gln Asn Met Asn Asn Ala Phe           
    125                 130                 135                           

cag gtg ctc atg gag ctg gaa aaa cct gtg ctc ata tca ctg gga aga        485
Gln Val Leu Met Glu Leu Glu Lys Pro Val Leu Ile Ser Leu Gly Arg           
140                 145                 150                 155           

ggg cgt tac tac aag gag acc tct ggc ctg atg ctg gac gtt ggt ccc        533
Gly Arg Tyr Tyr Lys Glu Thr Ser Gly Leu Met Leu Asp Val Gly Pro           
                160                 165                 170               

tac atg aag gcg ctt gag tat gcc tgt ggc atc aaa gcc gag gtg gtg        581
Tyr Met Lys Ala Leu Glu Tyr Ala Cys Gly Ile Lys Ala Glu Val Val           
            175                 180                 185                   

ggg aag cct tct cct gag ttt ttc aag tct gcc ctg caa gcg ata gga        629
Gly Lys Pro Ser Pro Glu Phe Phe Lys Ser Ala Leu Gln Ala Ile Gly           
        190                 195                 200                       

gtg gaa gcc cac cag gcc gtc atg att ggg gac gat atc gtg ggc gac        677
Val Glu Ala His Gln Ala Val Met Ile Gly Asp Asp Ile Val Gly Asp           
    205                 210                 215                           

gtc ggc ggt gcc cag cgg tgt gga atg aga gcg ctg cag gtg cgc acc        725
Val Gly Gly Ala Gln Arg Cys Gly Met Arg Ala Leu Gln Val Arg Thr           
220                 225                 230                 235           

ggg aag ttc agg ccc agt gac gag cac cat ccg gaa gtg aag gct gat        773
Gly Lys Phe Arg Pro Ser Asp Glu His His Pro Glu Val Lys Ala Asp           
                240                 245                 250               

ggg tac gtg gac aac ctc gca gag gca gtg gac ctg ctg ctg cag cac        821
Gly Tyr Val Asp Asn Leu Ala Glu Ala Val Asp Leu Leu Leu Gln His           
            255                 260                 265                   

gcc gac aag tga tggcctcctg ggagagcccc gcctcctcca cccctgcctc            873
Ala Asp Lys                                                               
        270                                                               

tcctccaccc ctgcctcccc tccacccctg cctctcctcc acccgcccag gagagcccca      933

cctcctccac ccctgcctct cctccacccc tgcctcccct ccacctgccc cagtgcccag      993

accaaccaag gccctgacag ccctgccttc tgccctctgc cctgcatggg caggcatttg     1053

ttccctacct gggtggcctg ctcccctgcc tgggccctga cttcagctcc ctgtagtgaa     1113

gtccaggagg gtgggacagg cctgtcaggc ctctgggaat ctcccaaatc ccagaactca     1173

ccactcacca tgggccttta aatgcagtaa actccaccta accagattca ggggcactat     1233

gcccactgcc tcctcttcag actctttgca tttcagtgaa gagcctggaa gaaacccagg     1293

ggcctcctat gcacagatct tgcagcccag aaccaagtca gcctccctgc gactgcccag     1353

gcacactgcc caccacccca cccccgaaac aatgccagcc cgctgctttt tctatcctcc     1413

cagtcacctt tgcagacaaa gaccaggggc agctcccgag ggcactgtga aggctcccat     1473

gccacacagt gagaactgta gcctctgcgt ccaaggcaca cagggtactt tctggaccca     1533

ctgctggaca gacttgaagg tgtcatgccc ggtgtgtgca ggaggaaact aacagttcag     1593

taaactctgc cttgaccagc                                                 1613


<210>  344
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Ala Pro Trp Gly Lys Arg Leu Ala Gly Val Arg Gly Val Leu Leu 
1               5                   10                  15      


Asp Ile Ser Gly Val Leu Tyr Asp Ser Gly Ala Gly Gly Gly Thr Ala 
            20                  25                  30          


Ile Ala Gly Ser Val Glu Ala Val Ala Arg Leu Lys Arg Ser Arg Leu 
        35                  40                  45              


Lys Val Arg Phe Cys Thr Asn Glu Ser Gln Lys Ser Arg Ala Glu Leu 
    50                  55                  60                  


Val Gly Gln Leu Gln Arg Leu Gly Phe Asp Ile Ser Glu Gln Glu Val 
65                  70                  75                  80  


Thr Ala Pro Ala Pro Ala Ala Cys Gln Ile Leu Lys Glu Arg Gly Leu 
                85                  90                  95      


Arg Pro Tyr Leu Leu Ile His Asp Gly Val Arg Ser Glu Phe Asp Gln 
            100                 105                 110         


Ile Asp Thr Ser Asn Pro Asn Cys Val Val Ile Ala Asp Ala Gly Glu 
        115                 120                 125             


Ser Phe Ser Tyr Gln Asn Met Asn Asn Ala Phe Gln Val Leu Met Glu 
    130                 135                 140                 


Leu Glu Lys Pro Val Leu Ile Ser Leu Gly Arg Gly Arg Tyr Tyr Lys 
145                 150                 155                 160 


Glu Thr Ser Gly Leu Met Leu Asp Val Gly Pro Tyr Met Lys Ala Leu 
                165                 170                 175     


Glu Tyr Ala Cys Gly Ile Lys Ala Glu Val Val Gly Lys Pro Ser Pro 
            180                 185                 190         


Glu Phe Phe Lys Ser Ala Leu Gln Ala Ile Gly Val Glu Ala His Gln 
        195                 200                 205             


Ala Val Met Ile Gly Asp Asp Ile Val Gly Asp Val Gly Gly Ala Gln 
    210                 215                 220                 


Arg Cys Gly Met Arg Ala Leu Gln Val Arg Thr Gly Lys Phe Arg Pro 
225                 230                 235                 240 


Ser Asp Glu His His Pro Glu Val Lys Ala Asp Gly Tyr Val Asp Asn 
                245                 250                 255     


Leu Ala Glu Ala Val Asp Leu Leu Leu Gln His Ala Asp Lys 
            260                 265                 270 


<210>  345
<211>  1059
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (802)..(933)

<400>  345
ctcacagcat ggctgccttg ggtactcgga cttcacgtgg aaggccaggg ctccgagagc       60

aaatgcccca gcaagacaga agctcagccg cctttgatga cctagaagct aggcagcatc      120

cattgtactg ccttctatgg gttgtgagtg agtcccaaac ctgccttgac tcaaggaaac      180

ggaattaggc tctacgtctt gactaggtag tggcgaagtt ctggaagcac atgagtagga      240

gatactgtga cggtttcatc tttggaaaat accatctagc acacctgaat ctgctttcag      300

ggggtgtaag gggatttcca tggcaaaatt tgaagccaca tgtggtcact gctttgtact      360

gaggaaacaa agtgctctgg gcatccagaa agggggtacg ttttttctta ctgggataaa      420

tctggctgca ttttagctaa tcctggaaaa ttgatcgaca aaagcaaagg accaagaaag      480

ctgcttatat cagtgtctcc tccaccctca gcctccagta gcatccctac gttttacaat      540

tttatttatg tcactttaaa taaggacatt gagagggaaa aggcctcatc gacataccaa      600

ctacaggcca ggtggacctt cggtgcacac acaccccagc gcccacagag atccaggcct      660

cctgtgtatg aatgtgtgcc atgaatttag acctatttct cgccttccgg gctctctatt      720

cctcatcctc catccaagtg gccatcttgt gcaggccctg aaagcagcag atctcacctg      780

cattggagga tgagacgcca c atg aag aag aaa gaa gac gcc aca gac agc        831
                        Met Lys Lys Lys Glu Asp Ala Thr Asp Ser           
                        1               5                   10            

agc gca gta cca cct tcc aga gat gtg agt gtg acc gtc ttt gac ctt        879
Ser Ala Val Pro Pro Ser Arg Asp Val Ser Val Thr Val Phe Asp Leu           
                15                  20                  25                

cta gcc cag ctg ctt tcc ctg aat gca atg cat gag cag gcc agg caa        927
Leu Ala Gln Leu Leu Ser Leu Asn Ala Met His Glu Gln Ala Arg Gln           
            30                  35                  40                    

aac tag agagggaagc tgcccagcta acccacagaa ttatgagaga taaaaaatca         983
Asn                                                                       
                                                                          

ttgtcttaag ccactaagtc tgttatgcag caatatatag cattcataca aaaaaaaaaa     1043

aaaaaaaaaa aaaaaa                                                     1059


<210>  346
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Lys Lys Lys Glu Asp Ala Thr Asp Ser Ser Ala Val Pro Pro Ser 
1               5                   10                  15      


Arg Asp Val Ser Val Thr Val Phe Asp Leu Leu Ala Gln Leu Leu Ser 
            20                  25                  30          


Leu Asn Ala Met His Glu Gln Ala Arg Gln Asn 
        35                  40              


<210>  347
<211>  6266
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (32)..(5776)

<400>  347
ggttgcctac gcgctggtgg gccgtgggaa g atg gcg gac gga aag gga gac          52
                                   Met Ala Asp Gly Lys Gly Asp            
                                   1               5                      

gcc gcc gct gtc gcc ggg gct ggg gct gag gct ccg gcg gta gcg gga        100
Ala Ala Ala Val Ala Gly Ala Gly Ala Glu Ala Pro Ala Val Ala Gly           
        10                  15                  20                        

gcc gga gat gga gtc gag act gag tcc atg gtt cgg ggt cat cgc ccc        148
Ala Gly Asp Gly Val Glu Thr Glu Ser Met Val Arg Gly His Arg Pro           
    25                  30                  35                            

gta tct cca gcg ccg gga gcc tcg gga ctg cgg ccg tgt ctg tgg cag        196
Val Ser Pro Ala Pro Gly Ala Ser Gly Leu Arg Pro Cys Leu Trp Gln           
40                  45                  50                  55            

ctg gag aca gag ctg agg gag caa gag gtg tcg gag gtc tca tct ttg        244
Leu Glu Thr Glu Leu Arg Glu Gln Glu Val Ser Glu Val Ser Ser Leu           
                60                  65                  70                

aac tac tgc cgg agc ttc tgc cag acc tta ttg caa tat gca agc aac        292
Asn Tyr Cys Arg Ser Phe Cys Gln Thr Leu Leu Gln Tyr Ala Ser Asn           
            75                  80                  85                    

aag aat gca tca gaa cat att gtg tat ctt ctg gag gta tat cga ctt        340
Lys Asn Ala Ser Glu His Ile Val Tyr Leu Leu Glu Val Tyr Arg Leu           
        90                  95                  100                       

gcc atc caa agc ttt gcc agt gca cgt cca tac tta act act gaa tgt        388
Ala Ile Gln Ser Phe Ala Ser Ala Arg Pro Tyr Leu Thr Thr Glu Cys           
    105                 110                 115                           

gaa gat gtc ctc tta gtg ctt ggc aga tta gta ctg agt tgt ttc gaa        436
Glu Asp Val Leu Leu Val Leu Gly Arg Leu Val Leu Ser Cys Phe Glu           
120                 125                 130                 135           

tta ctg ctt tca gtg tct gaa agt gaa ctg cca tgt gaa gtc tgg cta        484
Leu Leu Leu Ser Val Ser Glu Ser Glu Leu Pro Cys Glu Val Trp Leu           
                140                 145                 150               

cca ttc ctt cag tct cta cag gag tca cat gat gca tta ttg gaa ttt        532
Pro Phe Leu Gln Ser Leu Gln Glu Ser His Asp Ala Leu Leu Glu Phe           
            155                 160                 165                   

ggg aat aat aac cta caa ata ttg gtt cat gtt acc aag gaa ggg gtg        580
Gly Asn Asn Asn Leu Gln Ile Leu Val His Val Thr Lys Glu Gly Val           
        170                 175                 180                       

tgg aaa aac cca gtt ctt ctt aaa att ctg tct caa cag cca gta gaa        628
Trp Lys Asn Pro Val Leu Leu Lys Ile Leu Ser Gln Gln Pro Val Glu           
    185                 190                 195                           

acg gag gaa gtc aat aaa ttg att gca caa gaa gga cct tcc ttt ctg        676
Thr Glu Glu Val Asn Lys Leu Ile Ala Gln Glu Gly Pro Ser Phe Leu           
200                 205                 210                 215           

caa atg cga ata aaa cat ttg ttg aaa tct aac tgc atc ccc cag gct        724
Gln Met Arg Ile Lys His Leu Leu Lys Ser Asn Cys Ile Pro Gln Ala           
                220                 225                 230               

act gct tta tca aaa cta tgt gca gaa tct aaa gaa att tca aat gtg        772
Thr Ala Leu Ser Lys Leu Cys Ala Glu Ser Lys Glu Ile Ser Asn Val           
            235                 240                 245                   

tca tct ttt cag caa gcc tat atc aca tgt tta tgt tct atg ctc cct        820
Ser Ser Phe Gln Gln Ala Tyr Ile Thr Cys Leu Cys Ser Met Leu Pro           
        250                 255                 260                       

aat gaa gat gct att aag gag att gca aag gtc gac tgc aag gaa gta        868
Asn Glu Asp Ala Ile Lys Glu Ile Ala Lys Val Asp Cys Lys Glu Val           
    265                 270                 275                           

cta gac atc att tgt aat ctg gaa tct gag ggg cag gat aac aca gca        916
Leu Asp Ile Ile Cys Asn Leu Glu Ser Glu Gly Gln Asp Asn Thr Ala           
280                 285                 290                 295           

ttt gtt ctt tgt acg act tac ctt acc cag cag ctc caa act gca agt        964
Phe Val Leu Cys Thr Thr Tyr Leu Thr Gln Gln Leu Gln Thr Ala Ser           
                300                 305                 310               

gta tat tgt tct tgg gaa ctg act ctt ttt tgg agt aaa ctg caa aga       1012
Val Tyr Cys Ser Trp Glu Leu Thr Leu Phe Trp Ser Lys Leu Gln Arg           
            315                 320                 325                   

aga att gac cct tct tta gat act ttt ttg gag cgc tgt cgt cag ttt       1060
Arg Ile Asp Pro Ser Leu Asp Thr Phe Leu Glu Arg Cys Arg Gln Phe           
        330                 335                 340                       

ggt gtc ata gct aaa acg cag cag cat tta ttt tgc ctc att aga gtt       1108
Gly Val Ile Ala Lys Thr Gln Gln His Leu Phe Cys Leu Ile Arg Val           
    345                 350                 355                           

ata caa act gaa gca caa gat gct ggt ctt ggg gtg tca att tta ctg       1156
Ile Gln Thr Glu Ala Gln Asp Ala Gly Leu Gly Val Ser Ile Leu Leu           
360                 365                 370                 375           

tgt gtc aga gct ctt caa ctc aga tca agt gaa gat gag gaa atg aag       1204
Cys Val Arg Ala Leu Gln Leu Arg Ser Ser Glu Asp Glu Glu Met Lys           
                380                 385                 390               

gca tca gtt tgt aaa aca att gcc tgt ctt tta cca gaa gat tta gaa       1252
Ala Ser Val Cys Lys Thr Ile Ala Cys Leu Leu Pro Glu Asp Leu Glu           
            395                 400                 405                   

gtt aga cga gcc tgt cag ctt aca gaa ttc tta att gaa ccc agt ttg       1300
Val Arg Arg Ala Cys Gln Leu Thr Glu Phe Leu Ile Glu Pro Ser Leu           
        410                 415                 420                       

gat gga ttt aat atg tta gaa gaa cta tat ttg caa cca gat caa aaa       1348
Asp Gly Phe Asn Met Leu Glu Glu Leu Tyr Leu Gln Pro Asp Gln Lys           
    425                 430                 435                           

ttt gat gaa gaa aat gca ccg gtt cca aat tct ctt cga tgt gag ctc       1396
Phe Asp Glu Glu Asn Ala Pro Val Pro Asn Ser Leu Arg Cys Glu Leu           
440                 445                 450                 455           

tta cta gct tta aaa gcc cac tgg cct ttt gat cct gag ttt tgg gac       1444
Leu Leu Ala Leu Lys Ala His Trp Pro Phe Asp Pro Glu Phe Trp Asp           
                460                 465                 470               

tgg aaa act tta aaa cga cac tgc cac caa ctt tta gga caa gaa gcc       1492
Trp Lys Thr Leu Lys Arg His Cys His Gln Leu Leu Gly Gln Glu Ala           
            475                 480                 485                   

tca gat tct gat gat gat tta agt ggc tat gaa atg tcc att aat gac       1540
Ser Asp Ser Asp Asp Asp Leu Ser Gly Tyr Glu Met Ser Ile Asn Asp           
        490                 495                 500                       

aca gat gtt tta gag tca ttt ctc agt gac tat gat gag ggt aaa gaa       1588
Thr Asp Val Leu Glu Ser Phe Leu Ser Asp Tyr Asp Glu Gly Lys Glu           
    505                 510                 515                           

gat aaa caa tat aga aga aga gat ttg aca gat cag cat aag gag aaa       1636
Asp Lys Gln Tyr Arg Arg Arg Asp Leu Thr Asp Gln His Lys Glu Lys           
520                 525                 530                 535           

aga gac aaa aaa cct att ggc tct tct gaa aga tat cag agg tgg ctt       1684
Arg Asp Lys Lys Pro Ile Gly Ser Ser Glu Arg Tyr Gln Arg Trp Leu           
                540                 545                 550               

cag tac aag ttt ttc tgt ttg tta tgt aag cgg gaa tgt ata gag gct       1732
Gln Tyr Lys Phe Phe Cys Leu Leu Cys Lys Arg Glu Cys Ile Glu Ala           
            555                 560                 565                   

aga att ctt cat cat tct aag atg cat atg gaa gat gga att tac acc       1780
Arg Ile Leu His His Ser Lys Met His Met Glu Asp Gly Ile Tyr Thr           
        570                 575                 580                       

tgt cca gtt tgt att aaa aaa ttt aag aga aaa gaa atg ttt gtt cct       1828
Cys Pro Val Cys Ile Lys Lys Phe Lys Arg Lys Glu Met Phe Val Pro           
    585                 590                 595                           

cat gtg atg gag cat gtt aaa atg cca cca agc aga agg gac cgc tct       1876
His Val Met Glu His Val Lys Met Pro Pro Ser Arg Arg Asp Arg Ser           
600                 605                 610                 615           

aaa aag aaa tta ctg tta aaa ggc tct caa aag ggt att tgt cct aag       1924
Lys Lys Lys Leu Leu Leu Lys Gly Ser Gln Lys Gly Ile Cys Pro Lys           
                620                 625                 630               

agc ccc tct gca atc cca gag caa aac cat tca ttg aat gac caa gcc       1972
Ser Pro Ser Ala Ile Pro Glu Gln Asn His Ser Leu Asn Asp Gln Ala           
            635                 640                 645                   

aaa gga gag tct cat gaa tat gtc aca ttc agc aaa tta gaa gat tgc       2020
Lys Gly Glu Ser His Glu Tyr Val Thr Phe Ser Lys Leu Glu Asp Cys           
        650                 655                 660                       

cac ctg caa gac aga gat ttg tat cca tgt ccc ggt aca gac tgt tcc       2068
His Leu Gln Asp Arg Asp Leu Tyr Pro Cys Pro Gly Thr Asp Cys Ser           
    665                 670                 675                           

cgt gtg ttt aag caa ttt aaa tac tta agt gtg cat ctt aaa gct gaa       2116
Arg Val Phe Lys Gln Phe Lys Tyr Leu Ser Val His Leu Lys Ala Glu           
680                 685                 690                 695           

cac caa aat aat gat gaa aat gcc aag cac tac ttg gat atg aaa aat       2164
His Gln Asn Asn Asp Glu Asn Ala Lys His Tyr Leu Asp Met Lys Asn           
                700                 705                 710               

aga aga gag aag tgt act tac tgt cga cga cat ttt atg tct gct ttt       2212
Arg Arg Glu Lys Cys Thr Tyr Cys Arg Arg His Phe Met Ser Ala Phe           
            715                 720                 725                   

cac ctt cga gag cac gaa caa gtg cat tgt ggg cct cag cct tat atg       2260
His Leu Arg Glu His Glu Gln Val His Cys Gly Pro Gln Pro Tyr Met           
        730                 735                 740                       

tgt gta tct ata gat tgc tat gct agg ttt gga tca gta aat gaa cta       2308
Cys Val Ser Ile Asp Cys Tyr Ala Arg Phe Gly Ser Val Asn Glu Leu           
    745                 750                 755                           

ctt aac cat aaa caa aag cat gac gat ctg cgt tac aaa tgt gaa tta       2356
Leu Asn His Lys Gln Lys His Asp Asp Leu Arg Tyr Lys Cys Glu Leu           
760                 765                 770                 775           

aat ggc tgt aat att gtt ttc agt gac ttg gga cag ctt tac cac cat       2404
Asn Gly Cys Asn Ile Val Phe Ser Asp Leu Gly Gln Leu Tyr His His           
                780                 785                 790               

gaa gca caa cac ttt agg gat gca tct tac aca tgc aac ttc ctt ggc       2452
Glu Ala Gln His Phe Arg Asp Ala Ser Tyr Thr Cys Asn Phe Leu Gly           
            795                 800                 805                   

tgt aaa aag ttc tat tac tcc aaa att gaa tac cag aat cac ctc tca       2500
Cys Lys Lys Phe Tyr Tyr Ser Lys Ile Glu Tyr Gln Asn His Leu Ser           
        810                 815                 820                       

atg cat aat gtt gaa aat tca aat gga gac ata aag aaa tca gtg aaa       2548
Met His Asn Val Glu Asn Ser Asn Gly Asp Ile Lys Lys Ser Val Lys           
    825                 830                 835                           

ctt gag gag tct gca aca ggt gaa aag caa gat tgt att aat cag ccc       2596
Leu Glu Glu Ser Ala Thr Gly Glu Lys Gln Asp Cys Ile Asn Gln Pro           
840                 845                 850                 855           

cat cta ctt aac caa act gat aaa tca cat tta cct gaa gat ctt ttc       2644
His Leu Leu Asn Gln Thr Asp Lys Ser His Leu Pro Glu Asp Leu Phe           
                860                 865                 870               

tgt gca gaa tca gct aat tct caa ata gat aca gaa act gca gaa aac       2692
Cys Ala Glu Ser Ala Asn Ser Gln Ile Asp Thr Glu Thr Ala Glu Asn           
            875                 880                 885                   

ctg aaa gaa aac agt gac agt aat tct agt gat cag tta agt cat agc       2740
Leu Lys Glu Asn Ser Asp Ser Asn Ser Ser Asp Gln Leu Ser His Ser           
        890                 895                 900                       

tct tca gct tca atg aat gaa gag cta att gac aca cta gat cac tct       2788
Ser Ser Ala Ser Met Asn Glu Glu Leu Ile Asp Thr Leu Asp His Ser           
    905                 910                 915                           

gaa act atg cag gat gta ttg tta tct aat gag aaa gtc ttt ggg ccc       2836
Glu Thr Met Gln Asp Val Leu Leu Ser Asn Glu Lys Val Phe Gly Pro           
920                 925                 930                 935           

tcc agt tta aaa gaa aaa tgt tcc agt atg gca gtt tgt ttt gac ggg       2884
Ser Ser Leu Lys Glu Lys Cys Ser Ser Met Ala Val Cys Phe Asp Gly           
                940                 945                 950               

act aag ttt acc tgt ggt ttt gat ggc tgt ggt tcc aca tac aaa aat       2932
Thr Lys Phe Thr Cys Gly Phe Asp Gly Cys Gly Ser Thr Tyr Lys Asn           
            955                 960                 965                   

gca aga gga atg cag aaa cat tta cgg aag gtt cat cca tac cat ttc       2980
Ala Arg Gly Met Gln Lys His Leu Arg Lys Val His Pro Tyr His Phe           
        970                 975                 980                       

aag ccc aaa aag ata aag acg aaa gat ctg ttt ccc tct ttg ggt aat       3028
Lys Pro Lys Lys Ile Lys Thr Lys Asp Leu Phe Pro Ser Leu Gly Asn           
    985                 990                 995                           

gaa  cat aat cag aca act  gaa aag ttg gat gca  gaa cct aaa ccc        3073
Glu  His Asn Gln Thr Thr  Glu Lys Leu Asp Ala  Glu Pro Lys Pro            
1000                 1005                 1010                            

tgc  tca gat aca aac agt  gac tcc cca gat gaa  ggt cta gat cac        3118
Cys  Ser Asp Thr Asn Ser  Asp Ser Pro Asp Glu  Gly Leu Asp His            
1015                 1020                 1025                            

aat  att cac att aaa tgt  aaa cga gaa cat caa  ggt tat tcc tca        3163
Asn  Ile His Ile Lys Cys  Lys Arg Glu His Gln  Gly Tyr Ser Ser            
1030                 1035                 1040                            

gaa  tcc tcc att tgt gct  tct aaa agg ccc tgt  aca gag gat acc        3208
Glu  Ser Ser Ile Cys Ala  Ser Lys Arg Pro Cys  Thr Glu Asp Thr            
1045                 1050                 1055                            

atg  ttg gaa ctt ctg tta  cgc ttg aaa cat tta  agc ttg aaa aac        3253
Met  Leu Glu Leu Leu Leu  Arg Leu Lys His Leu  Ser Leu Lys Asn            
1060                 1065                 1070                            

tca  ata aca cat gga tct  ttc tca ggg tca ttg  cag ggg tac cca        3298
Ser  Ile Thr His Gly Ser  Phe Ser Gly Ser Leu  Gln Gly Tyr Pro            
1075                 1080                 1085                            

tcc  agt ggt gct aag tct  ctt cag tca gtt tca  tct atc tca gac        3343
Ser  Ser Gly Ala Lys Ser  Leu Gln Ser Val Ser  Ser Ile Ser Asp            
1090                 1095                 1100                            

ctt  aat ttt cag aat caa  gat gaa aac atg cca  agt cag tac ctt        3388
Leu  Asn Phe Gln Asn Gln  Asp Glu Asn Met Pro  Ser Gln Tyr Leu            
1105                 1110                 1115                            

gca  cag ttg gcg gct aag  ccg ttt ttc tgt gag  ctt caa gga tgc        3433
Ala  Gln Leu Ala Ala Lys  Pro Phe Phe Cys Glu  Leu Gln Gly Cys            
1120                 1125                 1130                            

aaa  tat gaa ttt gtg acc  aga gag gct ctg tta  atg cat tat ctt        3478
Lys  Tyr Glu Phe Val Thr  Arg Glu Ala Leu Leu  Met His Tyr Leu            
1135                 1140                 1145                            

aaa  aag cat aat tat tca  aaa gaa aaa gtc ctt  cag tta acc atg        3523
Lys  Lys His Asn Tyr Ser  Lys Glu Lys Val Leu  Gln Leu Thr Met            
1150                 1155                 1160                            

ttc  caa cat cgg tat tcc  cca ttt cag tgt cat  att tgc caa agg        3568
Phe  Gln His Arg Tyr Ser  Pro Phe Gln Cys His  Ile Cys Gln Arg            
1165                 1170                 1175                            

tca  ttt aca aga aaa aca  cac ctt agg att cat  tat aaa aat aaa        3613
Ser  Phe Thr Arg Lys Thr  His Leu Arg Ile His  Tyr Lys Asn Lys            
1180                 1185                 1190                            

cat  caa att ggc agt gac  aga gca act cac aaa  cta tta gat aat        3658
His  Gln Ile Gly Ser Asp  Arg Ala Thr His Lys  Leu Leu Asp Asn            
1195                 1200                 1205                            

gaa  aag tgt gat cat gaa  ggc cca tgt tca gta  gat agg ttg aaa        3703
Glu  Lys Cys Asp His Glu  Gly Pro Cys Ser Val  Asp Arg Leu Lys            
1210                 1215                 1220                            

ggt  gat tgt tct gca gaa  ctt gga ggt gat ccc  agt agt aac tct        3748
Gly  Asp Cys Ser Ala Glu  Leu Gly Gly Asp Pro  Ser Ser Asn Ser            
1225                 1230                 1235                            

gag  aaa cca cac tgt cat  cct aaa aag gat gaa  tgt agt tct gaa        3793
Glu  Lys Pro His Cys His  Pro Lys Lys Asp Glu  Cys Ser Ser Glu            
1240                 1245                 1250                            

aca  gat ttg gaa tca tct  tgt gaa gaa aca gaa  agt aaa aca tct        3838
Thr  Asp Leu Glu Ser Ser  Cys Glu Glu Thr Glu  Ser Lys Thr Ser            
1255                 1260                 1265                            

gac  att tca tca cca ata  ggc agc cat aga gaa  gaa caa gaa gga        3883
Asp  Ile Ser Ser Pro Ile  Gly Ser His Arg Glu  Glu Gln Glu Gly            
1270                 1275                 1280                            

aga  gag ggc aga ggt agc  agg cga act gtt gct  aaa gga aat ctg        3928
Arg  Glu Gly Arg Gly Ser  Arg Arg Thr Val Ala  Lys Gly Asn Leu            
1285                 1290                 1295                            

tgt  tat att ttg aat aaa  tac cac aaa cca ttc  cat tgt att cat        3973
Cys  Tyr Ile Leu Asn Lys  Tyr His Lys Pro Phe  His Cys Ile His            
1300                 1305                 1310                            

aaa  act tgc aac tcc tca  ttc acc aat cta aaa  ggc tta att cgc        4018
Lys  Thr Cys Asn Ser Ser  Phe Thr Asn Leu Lys  Gly Leu Ile Arg            
1315                 1320                 1325                            

cat  tac aga act gta cat  cag tac aac aaa gaa  cag tta tgt ttg        4063
His  Tyr Arg Thr Val His  Gln Tyr Asn Lys Glu  Gln Leu Cys Leu            
1330                 1335                 1340                            

gag  aaa gac aaa gca aga  acc aaa agg gaa ctt  gtc aaa tgt aaa        4108
Glu  Lys Asp Lys Ala Arg  Thr Lys Arg Glu Leu  Val Lys Cys Lys            
1345                 1350                 1355                            

aag  ata ttt gct tgc aaa  tat aag gaa tgt aat  aaa cgc ttc ctg        4153
Lys  Ile Phe Ala Cys Lys  Tyr Lys Glu Cys Asn  Lys Arg Phe Leu            
1360                 1365                 1370                            

tgt  tcc aaa gct ctt gct  aag cac tgt agt gat  tct cat aac cta        4198
Cys  Ser Lys Ala Leu Ala  Lys His Cys Ser Asp  Ser His Asn Leu            
1375                 1380                 1385                            

gac  cat att gaa gag cct  aaa gta ctt tcc gaa  gct gga tct gca        4243
Asp  His Ile Glu Glu Pro  Lys Val Leu Ser Glu  Ala Gly Ser Ala            
1390                 1395                 1400                            

gca  agg ttt tct tgt aac  cag cct cag tgc cct  gct gtt ttt tat        4288
Ala  Arg Phe Ser Cys Asn  Gln Pro Gln Cys Pro  Ala Val Phe Tyr            
1405                 1410                 1415                            

aca  ttc aac aag ttg aag  cac cac ttg atg gaa  cag cat aat att        4333
Thr  Phe Asn Lys Leu Lys  His His Leu Met Glu  Gln His Asn Ile            
1420                 1425                 1430                            

gaa  ggg gaa ata cat tca  gat tat gaa att cat  tgt gat ctt aat        4378
Glu  Gly Glu Ile His Ser  Asp Tyr Glu Ile His  Cys Asp Leu Asn            
1435                 1440                 1445                            

ggc  tgt ggc cag att ttc  acc cat cgc agt aat  tac tca caa cat        4423
Gly  Cys Gly Gln Ile Phe  Thr His Arg Ser Asn  Tyr Ser Gln His            
1450                 1455                 1460                            

gta  tat tac cga cat aaa  gac tat tat gat gat  ttg ttt aga agc        4468
Val  Tyr Tyr Arg His Lys  Asp Tyr Tyr Asp Asp  Leu Phe Arg Ser            
1465                 1470                 1475                            

cag  aaa gta gca aat gag  aga cta cta agg agt  gaa aag gta tgt        4513
Gln  Lys Val Ala Asn Glu  Arg Leu Leu Arg Ser  Glu Lys Val Cys            
1480                 1485                 1490                            

caa  aca gct gat act cag  ggg cat gaa cat cag  acc acc agg aga        4558
Gln  Thr Ala Asp Thr Gln  Gly His Glu His Gln  Thr Thr Arg Arg            
1495                 1500                 1505                            

tca  ttt aat gct aag tct  aaa aaa tgt ggc tta  atc aaa gaa aag        4603
Ser  Phe Asn Ala Lys Ser  Lys Lys Cys Gly Leu  Ile Lys Glu Lys            
1510                 1515                 1520                            

aaa  gcc cca ata agt ttt  aaa acc aga gct gag  gcc ctc cat atg        4648
Lys  Ala Pro Ile Ser Phe  Lys Thr Arg Ala Glu  Ala Leu His Met            
1525                 1530                 1535                            

tgt  gtg gag cac tct gag  cac aca cag tac ccc  tgc atg gtt caa        4693
Cys  Val Glu His Ser Glu  His Thr Gln Tyr Pro  Cys Met Val Gln            
1540                 1545                 1550                            

gga  tgc tta tct gtg gtg  aag ttg gag agc agc  att gtg agg cat        4738
Gly  Cys Leu Ser Val Val  Lys Leu Glu Ser Ser  Ile Val Arg His            
1555                 1560                 1565                            

tac  aaa cgc act cat cag  atg agt agt gcc tat  tta gag caa cag        4783
Tyr  Lys Arg Thr His Gln  Met Ser Ser Ala Tyr  Leu Glu Gln Gln            
1570                 1575                 1580                            

atg  gag aat ctt gtt gtt  tgc gtt aag tac ggt  acc aaa att aag        4828
Met  Glu Asn Leu Val Val  Cys Val Lys Tyr Gly  Thr Lys Ile Lys            
1585                 1590                 1595                            

gag  gaa ccc cct tct gaa  gca gat ccc tgt ata  aag aaa gaa gaa        4873
Glu  Glu Pro Pro Ser Glu  Ala Asp Pro Cys Ile  Lys Lys Glu Glu            
1600                 1605                 1610                            

aat  aga agc tgt gaa tca  gag cgc aca gaa cac  agc cat tcc ccg        4918
Asn  Arg Ser Cys Glu Ser  Glu Arg Thr Glu His  Ser His Ser Pro            
1615                 1620                 1625                            

ggt  gac agt agt gca ccc  atc cag aac act gat  tgc tgt cat tca        4963
Gly  Asp Ser Ser Ala Pro  Ile Gln Asn Thr Asp  Cys Cys His Ser            
1630                 1635                 1640                            

agt  gaa agg gat gga ggt  cag aaa ggg tgc ata  gaa agc agc tca        5008
Ser  Glu Arg Asp Gly Gly  Gln Lys Gly Cys Ile  Glu Ser Ser Ser            
1645                 1650                 1655                            

gta  ttt gat gca gat act  ctg ctc tac agg gga  act ttg aaa tgt        5053
Val  Phe Asp Ala Asp Thr  Leu Leu Tyr Arg Gly  Thr Leu Lys Cys            
1660                 1665                 1670                            

aat  cat agt tcc aaa acc  act tcc cta gaa cag  tgt aat ata gtt        5098
Asn  His Ser Ser Lys Thr  Thr Ser Leu Glu Gln  Cys Asn Ile Val            
1675                 1680                 1685                            

cag  cct cct cct cct tgt  aaa ata gaa aat tcc  ata cct aat ccc        5143
Gln  Pro Pro Pro Pro Cys  Lys Ile Glu Asn Ser  Ile Pro Asn Pro            
1690                 1695                 1700                            

aat  ggg act gaa agt ggg  act tat ttc aca agt  ttc cag ctg cct        5188
Asn  Gly Thr Glu Ser Gly  Thr Tyr Phe Thr Ser  Phe Gln Leu Pro            
1705                 1710                 1715                            

tta  cca agg atc aaa gaa  tca gaa act agg cag  cat agt tca ggg        5233
Leu  Pro Arg Ile Lys Glu  Ser Glu Thr Arg Gln  His Ser Ser Gly            
1720                 1725                 1730                            

caa  gaa aac act gta aaa  aat cca acc cat gtc  cca aaa gag aat        5278
Gln  Glu Asn Thr Val Lys  Asn Pro Thr His Val  Pro Lys Glu Asn            
1735                 1740                 1745                            

ttt  agg aaa cat tca cag  ccc cgg tca ttt gat  ttg aag act tac        5323
Phe  Arg Lys His Ser Gln  Pro Arg Ser Phe Asp  Leu Lys Thr Tyr            
1750                 1755                 1760                            

aaa  cct atg gga ttt gaa  tct tca ttt ctg aaa  ttt att cag gaa        5368
Lys  Pro Met Gly Phe Glu  Ser Ser Phe Leu Lys  Phe Ile Gln Glu            
1765                 1770                 1775                            

agt  gaa gag aaa gaa gat  gat ttt gat gat tgg  gag cct tca gag        5413
Ser  Glu Glu Lys Glu Asp  Asp Phe Asp Asp Trp  Glu Pro Ser Glu            
1780                 1785                 1790                            

cac  tta aca tta agt aat  tct tca cag tcc agt  aat gat tta aca        5458
His  Leu Thr Leu Ser Asn  Ser Ser Gln Ser Ser  Asn Asp Leu Thr            
1795                 1800                 1805                            

ggg  aat gtt gtg gca aat  aat atg gtg aat gac  agt gaa cct gaa        5503
Gly  Asn Val Val Ala Asn  Asn Met Val Asn Asp  Ser Glu Pro Glu            
1810                 1815                 1820                            

gtt  gac ata cct cat tct  tcc agt gac tct aca  att cat gag aac        5548
Val  Asp Ile Pro His Ser  Ser Ser Asp Ser Thr  Ile His Glu Asn            
1825                 1830                 1835                            

ctg  act gca atc cca cct  tta ata gta gct gaa  aca aca aca gtt        5593
Leu  Thr Ala Ile Pro Pro  Leu Ile Val Ala Glu  Thr Thr Thr Val            
1840                 1845                 1850                            

cct  tcc ttg gaa aac ctg  agg gtt gta ttg gac  aaa gca tta aca        5638
Pro  Ser Leu Glu Asn Leu  Arg Val Val Leu Asp  Lys Ala Leu Thr            
1855                 1860                 1865                            

gac  tgt gga gag ctt gcc  tta aaa cag ctt cat  tat ctt cgg cca        5683
Asp  Cys Gly Glu Leu Ala  Leu Lys Gln Leu His  Tyr Leu Arg Pro            
1870                 1875                 1880                            

gtg  gtg gtt ctt gaa aga  tct aag ttt tcc aca  cca att tta gac        5728
Val  Val Val Leu Glu Arg  Ser Lys Phe Ser Thr  Pro Ile Leu Asp            
1885                 1890                 1895                            

tta  ttt cca aca aaa aag  aca gat gag ctt tgt  gta gga agt tca        5773
Leu  Phe Pro Thr Lys Lys  Thr Asp Glu Leu Cys  Val Gly Ser Ser            
1900                 1905                 1910                            

taa gtagcaattt tgttttagta acagactggc tccaacactg caacatgggg            5826

acatttgcca actcgaacaa aggctgagaa gcagccacac cgttgtttag ggtagaatag     5886

gctgtgtatt tacatgaatg tataatatct atgtcagcag tattggctga gtccattagc     5946

tctccagttg gtttaatgat tgggtttatt tttgtttgtt tgtttattaa aaaaatggaa     6006

ctgtacactt gtttggtgct aattaataca tcaaaatata ctggggcttc ctttttcaaa     6066

ttaagtgtgc atgattgtat atggaacaaa tactaaggtc ccagggtggg agggctaggg     6126

aaagggatat ggagttctta cttgacttga atgtgcacct gagggtgctt tgtgtaatat     6186

attgtacact acagcatctt atattttttg agttgagttt caataaatta caatttttca     6246

cccaaaaaaa aaaaaaaaaa                                                 6266


<210>  348
<211>  1914
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Ala Asp Gly Lys Gly Asp Ala Ala Ala Val Ala Gly Ala Gly Ala 
1               5                   10                  15      


Glu Ala Pro Ala Val Ala Gly Ala Gly Asp Gly Val Glu Thr Glu Ser 
            20                  25                  30          


Met Val Arg Gly His Arg Pro Val Ser Pro Ala Pro Gly Ala Ser Gly 
        35                  40                  45              


Leu Arg Pro Cys Leu Trp Gln Leu Glu Thr Glu Leu Arg Glu Gln Glu 
    50                  55                  60                  


Val Ser Glu Val Ser Ser Leu Asn Tyr Cys Arg Ser Phe Cys Gln Thr 
65                  70                  75                  80  


Leu Leu Gln Tyr Ala Ser Asn Lys Asn Ala Ser Glu His Ile Val Tyr 
                85                  90                  95      


Leu Leu Glu Val Tyr Arg Leu Ala Ile Gln Ser Phe Ala Ser Ala Arg 
            100                 105                 110         


Pro Tyr Leu Thr Thr Glu Cys Glu Asp Val Leu Leu Val Leu Gly Arg 
        115                 120                 125             


Leu Val Leu Ser Cys Phe Glu Leu Leu Leu Ser Val Ser Glu Ser Glu 
    130                 135                 140                 


Leu Pro Cys Glu Val Trp Leu Pro Phe Leu Gln Ser Leu Gln Glu Ser 
145                 150                 155                 160 


His Asp Ala Leu Leu Glu Phe Gly Asn Asn Asn Leu Gln Ile Leu Val 
                165                 170                 175     


His Val Thr Lys Glu Gly Val Trp Lys Asn Pro Val Leu Leu Lys Ile 
            180                 185                 190         


Leu Ser Gln Gln Pro Val Glu Thr Glu Glu Val Asn Lys Leu Ile Ala 
        195                 200                 205             


Gln Glu Gly Pro Ser Phe Leu Gln Met Arg Ile Lys His Leu Leu Lys 
    210                 215                 220                 


Ser Asn Cys Ile Pro Gln Ala Thr Ala Leu Ser Lys Leu Cys Ala Glu 
225                 230                 235                 240 


Ser Lys Glu Ile Ser Asn Val Ser Ser Phe Gln Gln Ala Tyr Ile Thr 
                245                 250                 255     


Cys Leu Cys Ser Met Leu Pro Asn Glu Asp Ala Ile Lys Glu Ile Ala 
            260                 265                 270         


Lys Val Asp Cys Lys Glu Val Leu Asp Ile Ile Cys Asn Leu Glu Ser 
        275                 280                 285             


Glu Gly Gln Asp Asn Thr Ala Phe Val Leu Cys Thr Thr Tyr Leu Thr 
    290                 295                 300                 


Gln Gln Leu Gln Thr Ala Ser Val Tyr Cys Ser Trp Glu Leu Thr Leu 
305                 310                 315                 320 


Phe Trp Ser Lys Leu Gln Arg Arg Ile Asp Pro Ser Leu Asp Thr Phe 
                325                 330                 335     


Leu Glu Arg Cys Arg Gln Phe Gly Val Ile Ala Lys Thr Gln Gln His 
            340                 345                 350         


Leu Phe Cys Leu Ile Arg Val Ile Gln Thr Glu Ala Gln Asp Ala Gly 
        355                 360                 365             


Leu Gly Val Ser Ile Leu Leu Cys Val Arg Ala Leu Gln Leu Arg Ser 
    370                 375                 380                 


Ser Glu Asp Glu Glu Met Lys Ala Ser Val Cys Lys Thr Ile Ala Cys 
385                 390                 395                 400 


Leu Leu Pro Glu Asp Leu Glu Val Arg Arg Ala Cys Gln Leu Thr Glu 
                405                 410                 415     


Phe Leu Ile Glu Pro Ser Leu Asp Gly Phe Asn Met Leu Glu Glu Leu 
            420                 425                 430         


Tyr Leu Gln Pro Asp Gln Lys Phe Asp Glu Glu Asn Ala Pro Val Pro 
        435                 440                 445             


Asn Ser Leu Arg Cys Glu Leu Leu Leu Ala Leu Lys Ala His Trp Pro 
    450                 455                 460                 


Phe Asp Pro Glu Phe Trp Asp Trp Lys Thr Leu Lys Arg His Cys His 
465                 470                 475                 480 


Gln Leu Leu Gly Gln Glu Ala Ser Asp Ser Asp Asp Asp Leu Ser Gly 
                485                 490                 495     


Tyr Glu Met Ser Ile Asn Asp Thr Asp Val Leu Glu Ser Phe Leu Ser 
            500                 505                 510         


Asp Tyr Asp Glu Gly Lys Glu Asp Lys Gln Tyr Arg Arg Arg Asp Leu 
        515                 520                 525             


Thr Asp Gln His Lys Glu Lys Arg Asp Lys Lys Pro Ile Gly Ser Ser 
    530                 535                 540                 


Glu Arg Tyr Gln Arg Trp Leu Gln Tyr Lys Phe Phe Cys Leu Leu Cys 
545                 550                 555                 560 


Lys Arg Glu Cys Ile Glu Ala Arg Ile Leu His His Ser Lys Met His 
                565                 570                 575     


Met Glu Asp Gly Ile Tyr Thr Cys Pro Val Cys Ile Lys Lys Phe Lys 
            580                 585                 590         


Arg Lys Glu Met Phe Val Pro His Val Met Glu His Val Lys Met Pro 
        595                 600                 605             


Pro Ser Arg Arg Asp Arg Ser Lys Lys Lys Leu Leu Leu Lys Gly Ser 
    610                 615                 620                 


Gln Lys Gly Ile Cys Pro Lys Ser Pro Ser Ala Ile Pro Glu Gln Asn 
625                 630                 635                 640 


His Ser Leu Asn Asp Gln Ala Lys Gly Glu Ser His Glu Tyr Val Thr 
                645                 650                 655     


Phe Ser Lys Leu Glu Asp Cys His Leu Gln Asp Arg Asp Leu Tyr Pro 
            660                 665                 670         


Cys Pro Gly Thr Asp Cys Ser Arg Val Phe Lys Gln Phe Lys Tyr Leu 
        675                 680                 685             


Ser Val His Leu Lys Ala Glu His Gln Asn Asn Asp Glu Asn Ala Lys 
    690                 695                 700                 


His Tyr Leu Asp Met Lys Asn Arg Arg Glu Lys Cys Thr Tyr Cys Arg 
705                 710                 715                 720 


Arg His Phe Met Ser Ala Phe His Leu Arg Glu His Glu Gln Val His 
                725                 730                 735     


Cys Gly Pro Gln Pro Tyr Met Cys Val Ser Ile Asp Cys Tyr Ala Arg 
            740                 745                 750         


Phe Gly Ser Val Asn Glu Leu Leu Asn His Lys Gln Lys His Asp Asp 
        755                 760                 765             


Leu Arg Tyr Lys Cys Glu Leu Asn Gly Cys Asn Ile Val Phe Ser Asp 
    770                 775                 780                 


Leu Gly Gln Leu Tyr His His Glu Ala Gln His Phe Arg Asp Ala Ser 
785                 790                 795                 800 


Tyr Thr Cys Asn Phe Leu Gly Cys Lys Lys Phe Tyr Tyr Ser Lys Ile 
                805                 810                 815     


Glu Tyr Gln Asn His Leu Ser Met His Asn Val Glu Asn Ser Asn Gly 
            820                 825                 830         


Asp Ile Lys Lys Ser Val Lys Leu Glu Glu Ser Ala Thr Gly Glu Lys 
        835                 840                 845             


Gln Asp Cys Ile Asn Gln Pro His Leu Leu Asn Gln Thr Asp Lys Ser 
    850                 855                 860                 


His Leu Pro Glu Asp Leu Phe Cys Ala Glu Ser Ala Asn Ser Gln Ile 
865                 870                 875                 880 


Asp Thr Glu Thr Ala Glu Asn Leu Lys Glu Asn Ser Asp Ser Asn Ser 
                885                 890                 895     


Ser Asp Gln Leu Ser His Ser Ser Ser Ala Ser Met Asn Glu Glu Leu 
            900                 905                 910         


Ile Asp Thr Leu Asp His Ser Glu Thr Met Gln Asp Val Leu Leu Ser 
        915                 920                 925             


Asn Glu Lys Val Phe Gly Pro Ser Ser Leu Lys Glu Lys Cys Ser Ser 
    930                 935                 940                 


Met Ala Val Cys Phe Asp Gly Thr Lys Phe Thr Cys Gly Phe Asp Gly 
945                 950                 955                 960 


Cys Gly Ser Thr Tyr Lys Asn Ala Arg Gly Met Gln Lys His Leu Arg 
                965                 970                 975     


Lys Val His Pro Tyr His Phe Lys Pro Lys Lys Ile Lys Thr Lys Asp 
            980                 985                 990         


Leu Phe Pro Ser Leu Gly Asn Glu  His Asn Gln Thr Thr  Glu Lys Leu 
        995                 1000                 1005             


Asp Ala  Glu Pro Lys Pro Cys  Ser Asp Thr Asn Ser  Asp Ser Pro 
    1010                 1015                 1020             


Asp Glu  Gly Leu Asp His Asn  Ile His Ile Lys Cys  Lys Arg Glu 
    1025                 1030                 1035             


His Gln  Gly Tyr Ser Ser Glu  Ser Ser Ile Cys Ala  Ser Lys Arg 
    1040                 1045                 1050             


Pro Cys  Thr Glu Asp Thr Met  Leu Glu Leu Leu Leu  Arg Leu Lys 
    1055                 1060                 1065             


His Leu  Ser Leu Lys Asn Ser  Ile Thr His Gly Ser  Phe Ser Gly 
    1070                 1075                 1080             


Ser Leu  Gln Gly Tyr Pro Ser  Ser Gly Ala Lys Ser  Leu Gln Ser 
    1085                 1090                 1095             


Val Ser  Ser Ile Ser Asp Leu  Asn Phe Gln Asn Gln  Asp Glu Asn 
    1100                 1105                 1110             


Met Pro  Ser Gln Tyr Leu Ala  Gln Leu Ala Ala Lys  Pro Phe Phe 
    1115                 1120                 1125             


Cys Glu  Leu Gln Gly Cys Lys  Tyr Glu Phe Val Thr  Arg Glu Ala 
    1130                 1135                 1140             


Leu Leu  Met His Tyr Leu Lys  Lys His Asn Tyr Ser  Lys Glu Lys 
    1145                 1150                 1155             


Val Leu  Gln Leu Thr Met Phe  Gln His Arg Tyr Ser  Pro Phe Gln 
    1160                 1165                 1170             


Cys His  Ile Cys Gln Arg Ser  Phe Thr Arg Lys Thr  His Leu Arg 
    1175                 1180                 1185             


Ile His  Tyr Lys Asn Lys His  Gln Ile Gly Ser Asp  Arg Ala Thr 
    1190                 1195                 1200             


His Lys  Leu Leu Asp Asn Glu  Lys Cys Asp His Glu  Gly Pro Cys 
    1205                 1210                 1215             


Ser Val  Asp Arg Leu Lys Gly  Asp Cys Ser Ala Glu  Leu Gly Gly 
    1220                 1225                 1230             


Asp Pro  Ser Ser Asn Ser Glu  Lys Pro His Cys His  Pro Lys Lys 
    1235                 1240                 1245             


Asp Glu  Cys Ser Ser Glu Thr  Asp Leu Glu Ser Ser  Cys Glu Glu 
    1250                 1255                 1260             


Thr Glu  Ser Lys Thr Ser Asp  Ile Ser Ser Pro Ile  Gly Ser His 
    1265                 1270                 1275             


Arg Glu  Glu Gln Glu Gly Arg  Glu Gly Arg Gly Ser  Arg Arg Thr 
    1280                 1285                 1290             


Val Ala  Lys Gly Asn Leu Cys  Tyr Ile Leu Asn Lys  Tyr His Lys 
    1295                 1300                 1305             


Pro Phe  His Cys Ile His Lys  Thr Cys Asn Ser Ser  Phe Thr Asn 
    1310                 1315                 1320             


Leu Lys  Gly Leu Ile Arg His  Tyr Arg Thr Val His  Gln Tyr Asn 
    1325                 1330                 1335             


Lys Glu  Gln Leu Cys Leu Glu  Lys Asp Lys Ala Arg  Thr Lys Arg 
    1340                 1345                 1350             


Glu Leu  Val Lys Cys Lys Lys  Ile Phe Ala Cys Lys  Tyr Lys Glu 
    1355                 1360                 1365             


Cys Asn  Lys Arg Phe Leu Cys  Ser Lys Ala Leu Ala  Lys His Cys 
    1370                 1375                 1380             


Ser Asp  Ser His Asn Leu Asp  His Ile Glu Glu Pro  Lys Val Leu 
    1385                 1390                 1395             


Ser Glu  Ala Gly Ser Ala Ala  Arg Phe Ser Cys Asn  Gln Pro Gln 
    1400                 1405                 1410             


Cys Pro  Ala Val Phe Tyr Thr  Phe Asn Lys Leu Lys  His His Leu 
    1415                 1420                 1425             


Met Glu  Gln His Asn Ile Glu  Gly Glu Ile His Ser  Asp Tyr Glu 
    1430                 1435                 1440             


Ile His  Cys Asp Leu Asn Gly  Cys Gly Gln Ile Phe  Thr His Arg 
    1445                 1450                 1455             


Ser Asn  Tyr Ser Gln His Val  Tyr Tyr Arg His Lys  Asp Tyr Tyr 
    1460                 1465                 1470             


Asp Asp  Leu Phe Arg Ser Gln  Lys Val Ala Asn Glu  Arg Leu Leu 
    1475                 1480                 1485             


Arg Ser  Glu Lys Val Cys Gln  Thr Ala Asp Thr Gln  Gly His Glu 
    1490                 1495                 1500             


His Gln  Thr Thr Arg Arg Ser  Phe Asn Ala Lys Ser  Lys Lys Cys 
    1505                 1510                 1515             


Gly Leu  Ile Lys Glu Lys Lys  Ala Pro Ile Ser Phe  Lys Thr Arg 
    1520                 1525                 1530             


Ala Glu  Ala Leu His Met Cys  Val Glu His Ser Glu  His Thr Gln 
    1535                 1540                 1545             


Tyr Pro  Cys Met Val Gln Gly  Cys Leu Ser Val Val  Lys Leu Glu 
    1550                 1555                 1560             


Ser Ser  Ile Val Arg His Tyr  Lys Arg Thr His Gln  Met Ser Ser 
    1565                 1570                 1575             


Ala Tyr  Leu Glu Gln Gln Met  Glu Asn Leu Val Val  Cys Val Lys 
    1580                 1585                 1590             


Tyr Gly  Thr Lys Ile Lys Glu  Glu Pro Pro Ser Glu  Ala Asp Pro 
    1595                 1600                 1605             


Cys Ile  Lys Lys Glu Glu Asn  Arg Ser Cys Glu Ser  Glu Arg Thr 
    1610                 1615                 1620             


Glu His  Ser His Ser Pro Gly  Asp Ser Ser Ala Pro  Ile Gln Asn 
    1625                 1630                 1635             


Thr Asp  Cys Cys His Ser Ser  Glu Arg Asp Gly Gly  Gln Lys Gly 
    1640                 1645                 1650             


Cys Ile  Glu Ser Ser Ser Val  Phe Asp Ala Asp Thr  Leu Leu Tyr 
    1655                 1660                 1665             


Arg Gly  Thr Leu Lys Cys Asn  His Ser Ser Lys Thr  Thr Ser Leu 
    1670                 1675                 1680             


Glu Gln  Cys Asn Ile Val Gln  Pro Pro Pro Pro Cys  Lys Ile Glu 
    1685                 1690                 1695             


Asn Ser  Ile Pro Asn Pro Asn  Gly Thr Glu Ser Gly  Thr Tyr Phe 
    1700                 1705                 1710             


Thr Ser  Phe Gln Leu Pro Leu  Pro Arg Ile Lys Glu  Ser Glu Thr 
    1715                 1720                 1725             


Arg Gln  His Ser Ser Gly Gln  Glu Asn Thr Val Lys  Asn Pro Thr 
    1730                 1735                 1740             


His Val  Pro Lys Glu Asn Phe  Arg Lys His Ser Gln  Pro Arg Ser 
    1745                 1750                 1755             


Phe Asp  Leu Lys Thr Tyr Lys  Pro Met Gly Phe Glu  Ser Ser Phe 
    1760                 1765                 1770             


Leu Lys  Phe Ile Gln Glu Ser  Glu Glu Lys Glu Asp  Asp Phe Asp 
    1775                 1780                 1785             


Asp Trp  Glu Pro Ser Glu His  Leu Thr Leu Ser Asn  Ser Ser Gln 
    1790                 1795                 1800             


Ser Ser  Asn Asp Leu Thr Gly  Asn Val Val Ala Asn  Asn Met Val 
    1805                 1810                 1815             


Asn Asp  Ser Glu Pro Glu Val  Asp Ile Pro His Ser  Ser Ser Asp 
    1820                 1825                 1830             


Ser Thr  Ile His Glu Asn Leu  Thr Ala Ile Pro Pro  Leu Ile Val 
    1835                 1840                 1845             


Ala Glu  Thr Thr Thr Val Pro  Ser Leu Glu Asn Leu  Arg Val Val 
    1850                 1855                 1860             


Leu Asp  Lys Ala Leu Thr Asp  Cys Gly Glu Leu Ala  Leu Lys Gln 
    1865                 1870                 1875             


Leu His  Tyr Leu Arg Pro Val  Val Val Leu Glu Arg  Ser Lys Phe 
    1880                 1885                 1890             


Ser Thr  Pro Ile Leu Asp Leu  Phe Pro Thr Lys Lys  Thr Asp Glu 
    1895                 1900                 1905             


Leu Cys  Val Gly Ser Ser 
    1910                 


<210>  349
<211>  4937
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (114)..(965)

<400>  349
ctccgcactg ctcactcccg cgcagtgagg ttggcacagc caccgctctg tggctcgctt       60

ggttccctta gtcccgagcg ctcgcccact gcagattcct ttcccgtgca gac atg         116
                                                           Met            
                                                           1              

gcc tct ggc acc acc acc acc gcc gtg aag att gga ata att ggt gga        164
Ala Ser Gly Thr Thr Thr Thr Ala Val Lys Ile Gly Ile Ile Gly Gly           
            5                   10                  15                    

aca ggc ctg gat gat cca gaa att tta gaa gga aga act gaa aaa tat        212
Thr Gly Leu Asp Asp Pro Glu Ile Leu Glu Gly Arg Thr Glu Lys Tyr           
        20                  25                  30                        

gtg gat act cca ttt ggc aag cca tct gat gcc tta att ttg ggg aag        260
Val Asp Thr Pro Phe Gly Lys Pro Ser Asp Ala Leu Ile Leu Gly Lys           
    35                  40                  45                            

ata aaa aat gtt gat tgc gtc ctc ctt gca agg cat gga agg cag cac        308
Ile Lys Asn Val Asp Cys Val Leu Leu Ala Arg His Gly Arg Gln His           
50                  55                  60                  65            

acc atc atg cct tca aag gtc aac tac cag gcg aac atc tgg gct ttg        356
Thr Ile Met Pro Ser Lys Val Asn Tyr Gln Ala Asn Ile Trp Ala Leu           
                70                  75                  80                

aag gaa gag ggc tgt aca cat gtc ata gtg acc aca gct tgt ggc tcc        404
Lys Glu Glu Gly Cys Thr His Val Ile Val Thr Thr Ala Cys Gly Ser           
            85                  90                  95                    

ttg agg gag gag att cag ccc ggc gat att gtc att att gat cag ttc        452
Leu Arg Glu Glu Ile Gln Pro Gly Asp Ile Val Ile Ile Asp Gln Phe           
        100                 105                 110                       

att gac agg acc act atg aga cct cag tcc ttc tat gat gga agt cat        500
Ile Asp Arg Thr Thr Met Arg Pro Gln Ser Phe Tyr Asp Gly Ser His           
    115                 120                 125                           

tct tgt gcc aga gga gtg tgc cat att cca atg gct gag ccg ttt tgc        548
Ser Cys Ala Arg Gly Val Cys His Ile Pro Met Ala Glu Pro Phe Cys           
130                 135                 140                 145           

ccc aaa acg aga gag gtt ctt ata gag act gct aag aag cta gga ctc        596
Pro Lys Thr Arg Glu Val Leu Ile Glu Thr Ala Lys Lys Leu Gly Leu           
                150                 155                 160               

cgg tgc cac tca aag ggg aca atg gtc aca atc gag gga cct cgt ttt        644
Arg Cys His Ser Lys Gly Thr Met Val Thr Ile Glu Gly Pro Arg Phe           
            165                 170                 175                   

agc tcc cgg gca gaa agc ttc atg ttc cgc acc tgg ggg gcg gat gtt        692
Ser Ser Arg Ala Glu Ser Phe Met Phe Arg Thr Trp Gly Ala Asp Val           
        180                 185                 190                       

atc aac atg acc aca gtt cca gag gtg gtt ctt gct aag gag gct gga        740
Ile Asn Met Thr Thr Val Pro Glu Val Val Leu Ala Lys Glu Ala Gly           
    195                 200                 205                           

att tgt tac gca agt atc gcc atg gcg aca gat tat gac tgc tgg aag        788
Ile Cys Tyr Ala Ser Ile Ala Met Ala Thr Asp Tyr Asp Cys Trp Lys           
210                 215                 220                 225           

gag cac gag gaa gca gtt tcg gtg gac cgg gtc tta aag acc ctg aaa        836
Glu His Glu Glu Ala Val Ser Val Asp Arg Val Leu Lys Thr Leu Lys           
                230                 235                 240               

gaa aac gct aat aaa gcc aaa agc tta ctg ctc act acc ata cct cag        884
Glu Asn Ala Asn Lys Ala Lys Ser Leu Leu Leu Thr Thr Ile Pro Gln           
            245                 250                 255                   

ata ggg tcc aca gaa tgg tca gaa acc ctc cat aac ctg aag aat atg        932
Ile Gly Ser Thr Glu Trp Ser Glu Thr Leu His Asn Leu Lys Asn Met           
        260                 265                 270                       

gcc cag ttt tct gtt tta tta cca aga cat taa agtagcatgg ctgcccagga      985
Ala Gln Phe Ser Val Leu Leu Pro Arg His                                   
    275                 280                                               

gaaaagaaga cattctaatt ccagtcattt tgggaattcc tgcttaactt gaaaaaaata     1045

tgggaaagac atgcagcttt catgcccttg cctatcaaag agtatgttgt aagaaagaca     1105

agacattgtg tgtattagag actcctgaat gatttagaca acttcaaaat acagaagaaa     1165

agcaaatgac tagtaaacat gtgggaaaaa atattacatt ttaaggggga aaaaaaaacc     1225

caccattctc ttctccccct attaaatttg caacaataaa gggtggaggg taatctctac     1285

tttcctatac tgccaaagaa tgtgaggaag aaatgggact ctttggttat ttattgatgc     1345

gactgtaaat tggtacagta tttctggagg gcaatttggt aaaatgcatc aaaagactta     1405

aaaatacgga cgtactttgt gctgggaact ctacatctag caatttctct ttaaaaccat     1465

atcagagatg catacaaaga attatatata aagaagggtg tttaataatg atagttataa     1525

taataaataa ttgaaacaat ctgaatccct tgcaattgga ggtaaattat gtcttagtta     1585

taattagatt gtgaatcagc caactgaaaa tcctttttgc atatttcaat gtcctaaaaa     1645

gacacggttg ctctatatat gaagtgaaaa aaggatatgg tagcatttta tagtactagt     1705

tttgctttaa aatgctatgt aaatatacaa aaaaactaga aagaaatata tataaccttg     1765

ttattgtatt tgggggaggg atactgggat aatttttatt ttctttgaat ctttctgtgt     1825

cttcacattt ttctacagtg aatttaatca aatagtaaag ttgttgtaaa aataaaagtg     1885

gatttagaaa gatccagttc ttgaaaacac tgtttctggt aatgaagcag aatttaagtt     1945

ggtaatatta aggtgaatgt catttaaggg agttacatct ttattctgct aaagaagagg     2005

atcattgatt tctgtacagt cagaacagta cttgggtttg caacagcttt ctgagaaaag     2065

ctaggtgttt aatagtttaa ctgaaagttt aactatttaa aagactaaat gcacatttta     2125

tggtatctga tattttaaaa agtaatgttt gattctcctt tttatgagtt aaattatttt     2185

atacgagttg gtaatttttg ctttttaata aagtggaagc ttgctttttt aactcttttt     2245

ttattgttat tttatagaaa tgctttttgt tggccgggca cagttgctca tccatgtaat     2305

cccagcactg tgggaggccg agacgggtgg atcacaaggt caggagatcg agaccatcct     2365

ggctaatgcg ttgaaactcc gtctctacta aaaatacaaa aaattagctg ggcgtggtgg     2425

tgggcacctg tagtcccagc tactcaggag gctgaggcag gagaatggtg tgaacctggg     2485

aggtggagct tgcagtgagc agagcttgca gtgagacgag cttgtgccac tgcactccag     2545

cctgggcaac agagtaagac tcagtctcaa aaaaaaaaaa aagagtgaaa tgctttttgt     2605

ttgcttcagt tttttatcat ggggagatct ttttcctcag aattgttttc ttttcactgt     2665

aggctattac aggatacttc aggatcaaga tacagaacct tttatttaaa gagtttgtaa     2725

agtcaatgtg tttgtttgtg tctctgagat tgacttcaag ataataagct gctaattgta     2785

aacaaaacag ttaccctcca gtattaatat gactcattag tgtgagccat ttgggtcaag     2845

tatgattatg acccttggac ttcctgatgt agtattaaat ttcaactctg gttatccatt     2905

agcaatctgt agagaactta atgaacctga acccaggctt ctctagctct ggtaacgtgt     2965

gattgttttc actacaatat gatacataga tggtacctta cttttcctca ttcttaatag     3025

gtgtctaaga atgtcagggc aaaagtatgg gcatttttct tgctatgttc agaaagtaca     3085

gttctctcca acttgcagag gtacttttct tgattaaata gccttctcta gcaacatcat     3145

tttcagacta actaaatgaa tgcagtatac tcttttcttt gttctcaatc attcactcct     3205

tatgcaaagc caatataatt ttcctcatac cttatgcttg aggatattgt tgaagaacac     3265

ttcctggaac acttctcact tgtgatgctg tactaatttt ttttttttaa tttaagctag     3325

tatactaagt gaacaccatg gtcagttgtg agcattttgg tttccgcaaa ggatggatgg     3385

tgagcatcat gggaaagctg tagtttagtg acttagccct tagtgattaa tagatttgca     3445

tgtacataga agtctttgtt ggccttataa tctgctgtta tatttggcat ggattttcat     3505

ggttttgaga atgacatcct ggccctgtgg tccccgaggg tcatggtcct tgtgacctgg     3565

cccctgttca ctgccccctt cgctagcacg agttgctgtg cagggctgga ggtagctacc     3625

atggcttgtt tcaaggaagg aaactctggt acggtggcac cctcaggagt ggaggacagt     3685

gaacttcctt gaagagggag tgactaaggt gacctccaac ctgccctgag ccagctgccc     3745

tgcaggtgcc acgtgagcct gctctggcat ccacaggatg ctcctggagc ctcttctctg     3805

gctgctacct cagggcatgg ttgtggcccc accaacacct attttccaaa taattattca     3865

ttcttgtgac agtggcctga acatgttttt aattttctca acaagcattt agccagcact     3925

tatccagtga aacaatttga taaggtttca aggagtatct gatgggttag gaagtcacga     3985

aatgaggagt tcttgccaca tttgcagagt ccctccttga taaggtttgg cggtgtcccc     4045

acccaaatct catgttgaat tgtagttccc ataatcccca catgttgtgg gagggaccca     4105

gtgggaggta attaaatcat gggggtggtt acccccacac tgctgttctc atgatactga     4165

gttctcacaa gtcctgtttg ttttataagg ggcttttccc ccttttgctc aacacttctt     4225

cctgccatca tgtgaagaag gacgtgtttg tttccccttc tgccacgatt gtaagtttcc     4285

tgaggccttc ccagctatgt ggaactgtga gttaattaaa cctctttcct ttataaatta     4345

cccagtcatg ggcagtcctt tacagcagca tgagaatgga ctaatacact cctcaaatgt     4405

tttgaagatt gttgcacctt ggaactacca gtgtgcacac aatctggctc aatgtatata     4465

ttggcccagc aaggcaaaga actgaagttc caggatggaa gaacctgtgt tctcctcata     4525

atagtataga ataattcaag ataggcaaga aggacagcag taaatgaaga ccatggaaga     4585

aaagaaggaa tgccaaagat cgaggaaatc taccaagact agtagggtag tccagaagaa     4645

gctgtttcag ggcctgttgc cagctatgcc tttgagaacc tcgggatccc aaagaatgag     4705

gggaatttct tcagaaagac aatctcggca tgcattattt ctttgttttg aagattcact     4765

catgttgcat gcatctgtag cttgtgcctt ttttattgcc tagtagtatt ctgtcatatg     4825

cctatcttac aatttgatta tctattcacc tgttgatgaa tgtttgaatt ttttccattt     4885

gaggaatttt atgaataaag ctgctataag catgaaaaaa aaaaaaaaaa aa             4937


<210>  350
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  350

Met Ala Ser Gly Thr Thr Thr Thr Ala Val Lys Ile Gly Ile Ile Gly 
1               5                   10                  15      


Gly Thr Gly Leu Asp Asp Pro Glu Ile Leu Glu Gly Arg Thr Glu Lys 
            20                  25                  30          


Tyr Val Asp Thr Pro Phe Gly Lys Pro Ser Asp Ala Leu Ile Leu Gly 
        35                  40                  45              


Lys Ile Lys Asn Val Asp Cys Val Leu Leu Ala Arg His Gly Arg Gln 
    50                  55                  60                  


His Thr Ile Met Pro Ser Lys Val Asn Tyr Gln Ala Asn Ile Trp Ala 
65                  70                  75                  80  


Leu Lys Glu Glu Gly Cys Thr His Val Ile Val Thr Thr Ala Cys Gly 
                85                  90                  95      


Ser Leu Arg Glu Glu Ile Gln Pro Gly Asp Ile Val Ile Ile Asp Gln 
            100                 105                 110         


Phe Ile Asp Arg Thr Thr Met Arg Pro Gln Ser Phe Tyr Asp Gly Ser 
        115                 120                 125             


His Ser Cys Ala Arg Gly Val Cys His Ile Pro Met Ala Glu Pro Phe 
    130                 135                 140                 


Cys Pro Lys Thr Arg Glu Val Leu Ile Glu Thr Ala Lys Lys Leu Gly 
145                 150                 155                 160 


Leu Arg Cys His Ser Lys Gly Thr Met Val Thr Ile Glu Gly Pro Arg 
                165                 170                 175     


Phe Ser Ser Arg Ala Glu Ser Phe Met Phe Arg Thr Trp Gly Ala Asp 
            180                 185                 190         


Val Ile Asn Met Thr Thr Val Pro Glu Val Val Leu Ala Lys Glu Ala 
        195                 200                 205             


Gly Ile Cys Tyr Ala Ser Ile Ala Met Ala Thr Asp Tyr Asp Cys Trp 
    210                 215                 220                 


Lys Glu His Glu Glu Ala Val Ser Val Asp Arg Val Leu Lys Thr Leu 
225                 230                 235                 240 


Lys Glu Asn Ala Asn Lys Ala Lys Ser Leu Leu Leu Thr Thr Ile Pro 
                245                 250                 255     


Gln Ile Gly Ser Thr Glu Trp Ser Glu Thr Leu His Asn Leu Lys Asn 
            260                 265                 270         


Met Ala Gln Phe Ser Val Leu Leu Pro Arg His 
        275                 280             


<210>  351
<211>  4139
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (141)..(1247)

<400>  351
aagaagaccc cgttcttccg ggaaaatggc gactcccgct cgtgccccgg agtcaccgcc       60

gtccgcggat ccggcgctag tagcggggcc tgccgaggaa gccgagtgcc cgccgccgcg      120

ccagcctcag cccgcgcaga atg tgc tcg ctg ccc cgc ggc ttc gag ccc caa      173
                      Met Cys Ser Leu Pro Arg Gly Phe Glu Pro Gln         
                      1               5                   10              

gct ccc gag gac ttg gcg cag cgg agt ttg gtg gag ctg cgg gaa atg        221
Ala Pro Glu Asp Leu Ala Gln Arg Ser Leu Val Glu Leu Arg Glu Met           
            15                  20                  25                    

ttg aag cgc cag gag aga ctt ttg cgc aac gaa aaa ttc att tgc aaa        269
Leu Lys Arg Gln Glu Arg Leu Leu Arg Asn Glu Lys Phe Ile Cys Lys           
        30                  35                  40                        

ttg ccc gac aaa ggt aaa aag atc ttt gac tct ttt gcc aaa ctg aaa        317
Leu Pro Asp Lys Gly Lys Lys Ile Phe Asp Ser Phe Ala Lys Leu Lys           
    45                  50                  55                            

gct gcc att gca gaa tgt gaa gaa gtt aga aga aaa agt gaa ctg ttt        365
Ala Ala Ile Ala Glu Cys Glu Glu Val Arg Arg Lys Ser Glu Leu Phe           
60                  65                  70                  75            

aac cct gtt agt tta gac tgt aag cta agg caa aaa gca att gca gaa        413
Asn Pro Val Ser Leu Asp Cys Lys Leu Arg Gln Lys Ala Ile Ala Glu           
                80                  85                  90                

gtt gat gtg ggt aca gat aag gcc cag aat tct gac ccg ata ctt gat        461
Val Asp Val Gly Thr Asp Lys Ala Gln Asn Ser Asp Pro Ile Leu Asp           
            95                  100                 105                   

act tca tca cta gtt cct gga tgt tcc tct gta gat aac atc aag tca        509
Thr Ser Ser Leu Val Pro Gly Cys Ser Ser Val Asp Asn Ile Lys Ser           
        110                 115                 120                       

tct caa acc tca caa aac cag gga ctt gga cgt cct act ctt gaa ggt        557
Ser Gln Thr Ser Gln Asn Gln Gly Leu Gly Arg Pro Thr Leu Glu Gly           
    125                 130                 135                           

gat gaa gag act tca gag gtt gag tac aca gtg aat aag ggc cca gct        605
Asp Glu Glu Thr Ser Glu Val Glu Tyr Thr Val Asn Lys Gly Pro Ala           
140                 145                 150                 155           

tcc agc aat aga gac agg gta cca cct tca tct gaa gct agt gag cat        653
Ser Ser Asn Arg Asp Arg Val Pro Pro Ser Ser Glu Ala Ser Glu His           
                160                 165                 170               

cac ccg cgg cat cgt gtt tca agt caa gcg gaa gat act tcc agc agc        701
His Pro Arg His Arg Val Ser Ser Gln Ala Glu Asp Thr Ser Ser Ser           
            175                 180                 185                   

ttt gac aac ctg ttt att gac agg tta cag agg atc acc att gcg gac        749
Phe Asp Asn Leu Phe Ile Asp Arg Leu Gln Arg Ile Thr Ile Ala Asp           
        190                 195                 200                       

caa ggt gaa caa cag tca gaa gaa aac gca agt act aag aac ttg aca        797
Gln Gly Glu Gln Gln Ser Glu Glu Asn Ala Ser Thr Lys Asn Leu Thr           
    205                 210                 215                           

ggc ctt tcc agt ggg act gag aag aaa cct cat tac atg gaa gtg cta        845
Gly Leu Ser Ser Gly Thr Glu Lys Lys Pro His Tyr Met Glu Val Leu           
220                 225                 230                 235           

gaa atg cga gcc aaa aac cca gtg ccc cag ctg cgt aaa ttt aaa acc        893
Glu Met Arg Ala Lys Asn Pro Val Pro Gln Leu Arg Lys Phe Lys Thr           
                240                 245                 250               

aat gtg tta cct ttt cga caa aat gat tca tct agt cat tgc cag aag        941
Asn Val Leu Pro Phe Arg Gln Asn Asp Ser Ser Ser His Cys Gln Lys           
            255                 260                 265                   

agt ggg tct cct att tcc tca gaa gag cgg cgg cgc agg gat aag cag        989
Ser Gly Ser Pro Ile Ser Ser Glu Glu Arg Arg Arg Arg Asp Lys Gln           
        270                 275                 280                       

cat ctt gat gac atc aca gca gct cgg ctt cta cca ctt cac cat atg       1037
His Leu Asp Asp Ile Thr Ala Ala Arg Leu Leu Pro Leu His His Met           
    285                 290                 295                           

ccc acg cag ctg ctc tcc ata gaa gaa tcc ttg gca ctt cag aaa cag       1085
Pro Thr Gln Leu Leu Ser Ile Glu Glu Ser Leu Ala Leu Gln Lys Gln           
300                 305                 310                 315           

cag aaa cag aat tat gag gag atg caa gca aag ctc gca gcg caa aaa       1133
Gln Lys Gln Asn Tyr Glu Glu Met Gln Ala Lys Leu Ala Ala Gln Lys           
                320                 325                 330               

tta gct gaa aga ctg aat att aaa atg cgg agt tat aat cca gaa ggg       1181
Leu Ala Glu Arg Leu Asn Ile Lys Met Arg Ser Tyr Asn Pro Glu Gly           
            335                 340                 345                   

gag tct tca ggg aga tac cga gaa gta agg gat gaa gat gac gat tgg       1229
Glu Ser Ser Gly Arg Tyr Arg Glu Val Arg Asp Glu Asp Asp Asp Trp           
        350                 355                 360                       

tcc tct gat gaa ttc tga agataatctc ctaaatcact gacgttgaga              1277
Ser Ser Asp Glu Phe                                                       
    365                                                                   

tgtcatcatc ttacatcaga ctttctaact agtatcaaga tcagtgtcag atattgttga     1337

gggaagtaat tttataaagt tacacaaagg tagttataaa aaaagcccag tttgtctttc     1397

agaaggtgac tttcatgtgc ttgaaaagtt taatatttga atattgtgtt taaccacatg     1457

gtattaaaat tttgcaatat attgtgtatt ggtctgatat tttagtatat agtagaacat     1517

actttttttt tctttaagcc aaatgaaaag aggtaacttt gcttttttcc tttttcttac     1577

ctatcaaata gcatttatta catgtctttc agtgaaatac ttagttgttc caggcaccta     1637

aaatcaatta ggaagacata gttcccttct tttttgggta atgaagggag cagtctaaag     1697

aattgtatgc atgtttgcat ggggttattg agacattgga tgtgaaatac ctaggaagac     1757

atgtatggag aatgcttaac aaatgctctt ctcctttttc tgtcttccct taggaagaac     1817

gttatctctc ttctgattag gaaggacttc ccttttgagt agatgctgga aagtggaggt     1877

tttttttgtt ggtttgtttg tttggttttg tgtttttttt tgagatgggg tcttgctctg     1937

tcgcccaggc tggagtgcag tggcaggatc tcggctcact gcaatctagg tggaggtctt     1997

tttaaataac ctcatgttac ttcaggcaaa tctggtacag gagaagccca agctaactga     2057

gctgggtgaa ggcttgtgca tcacctggct tgagttcctt gctgtcacag atgataggtt     2117

catgtacaca acattaatgt ttgataagga aagcattttt tttttgttaa aattgaattg     2177

tcagtacttt acttttttcc ccccaaatag gtatatatag actgcagaag cttcagtccc     2237

atatataaac gttcatgtca ttttagagga ttatatggtt gtctccagag aaattaactt     2297

acattatcaa aaaattcttt gtctaatata ttggagtctt taaaagtgtt gaagaataaa     2357

atattaatta gaacaacttc aaatgctaag gtgatgtttt accgggactt aattaaatac     2417

aactttttcc tttcgaaaaa gactgttcac atttgcttcc aggtgtaatt attgctttca     2477

ttccttaccc ccctcaagca aatgtgaaaa gtatactgac ctaagattct cattagtttt     2537

agttcttaaa acgaatagta aatgatttca cagcgtaaaa tttgatgtta tttctggaag     2597

ctggatgata tggaagagtt catgtgcctg gacacacagt tccctgtaat cctgccatct     2657

agggagataa actctgttaa cattttgatg ttgtgttttt gcttattttt ctatgcatag     2717

ttatgcattt atattctcaa aaatgaaatc ataatgtaca ttgctttgta gtctgctcta     2777

tatattgtca atatgttccc atattaaata ttttgctttt tagacagctg taggatattt     2837

tatttcatgg gtataccata actttaagat ttatttccta ttcagcaatt tgattatgta     2897

ttataatgta atctgtaaat agtgatatga ttaacatctt aatcacatcc atagaaaatg     2957

acttatttcc agaagatacc gctctaaaaa tgaaattgtt aggtgaaagt gtttttgaga     3017

atttttatat atattactca ctgcagagat catgttcatt tacattccca ttagcaatat     3077

atccaatgct cagaattgaa aattactact taaaatcttt gcaaattgaa taattacaga     3137

aaagggctac atttaaaatt tgtatttgtt tttcttactt agtgaaggtt gtgttttttt     3197

tcatattcat tggccatgct atattcattc ttttgagaat tgctcattca tattttttct     3257

gttgcttgct tggagaattt gctctttttt tggcatataa gttcttaaga atgtccgtcc     3317

tttgtcatat attgtaactt tttttagcct tatttgtcat ttaacatagt ttgtggtatt     3377

tcagtataga agttgttttc tttaggagtc tacctttgtg tatgtgcttg aaagtatttt     3437

tgtaatccaa gaatggataa atgtccttat tttcttctag tattttctta tttcactttt     3497

acacctatct ttaaaaggaa tttaaatttt gtttatatac attaactaaa tcagtacaag     3557

tttggggtga aaaggaaatt tttaatccat ctcaaatgta tttggttata ttatataagg     3617

tagggatttg attttatttc gaagaattta ccaattggtt cagtatgtga aaccaccatt     3677

tcccctctga ttagtaatgc tatttttata gaatattaaa ttcttatgtg tcttttgtgt     3737

cttaggccaa tttctgggcc ttctgggttt tttctacact gtcaataatt atcgctttaa     3797

ttggtgttaa tatttggtag tacacaggtt ctcccttgtt cttttaaatt ttgtgaaata     3857

taacttacaa ataagtactt aaaacagagc ttaatgggta aagcaacagc tgtgtaatca     3917

caaactagat gcagaggagg tcttgccagc actccaaaat ctctgtgtgt cccctcttga     3977

cactcactgt ttcccccaga gctaactatc ctgacgtatg gtaattctcc ctctgtcctt     4037

ttaagaatta ttttaccagt tatgtgtata acaatatggt ttacattttg ctcacttttg     4097

acttatataa aaatagaata atactaaaaa aaaaaaaaaa aa                        4139


<210>  352
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Cys Ser Leu Pro Arg Gly Phe Glu Pro Gln Ala Pro Glu Asp Leu 
1               5                   10                  15      


Ala Gln Arg Ser Leu Val Glu Leu Arg Glu Met Leu Lys Arg Gln Glu 
            20                  25                  30          


Arg Leu Leu Arg Asn Glu Lys Phe Ile Cys Lys Leu Pro Asp Lys Gly 
        35                  40                  45              


Lys Lys Ile Phe Asp Ser Phe Ala Lys Leu Lys Ala Ala Ile Ala Glu 
    50                  55                  60                  


Cys Glu Glu Val Arg Arg Lys Ser Glu Leu Phe Asn Pro Val Ser Leu 
65                  70                  75                  80  


Asp Cys Lys Leu Arg Gln Lys Ala Ile Ala Glu Val Asp Val Gly Thr 
                85                  90                  95      


Asp Lys Ala Gln Asn Ser Asp Pro Ile Leu Asp Thr Ser Ser Leu Val 
            100                 105                 110         


Pro Gly Cys Ser Ser Val Asp Asn Ile Lys Ser Ser Gln Thr Ser Gln 
        115                 120                 125             


Asn Gln Gly Leu Gly Arg Pro Thr Leu Glu Gly Asp Glu Glu Thr Ser 
    130                 135                 140                 


Glu Val Glu Tyr Thr Val Asn Lys Gly Pro Ala Ser Ser Asn Arg Asp 
145                 150                 155                 160 


Arg Val Pro Pro Ser Ser Glu Ala Ser Glu His His Pro Arg His Arg 
                165                 170                 175     


Val Ser Ser Gln Ala Glu Asp Thr Ser Ser Ser Phe Asp Asn Leu Phe 
            180                 185                 190         


Ile Asp Arg Leu Gln Arg Ile Thr Ile Ala Asp Gln Gly Glu Gln Gln 
        195                 200                 205             


Ser Glu Glu Asn Ala Ser Thr Lys Asn Leu Thr Gly Leu Ser Ser Gly 
    210                 215                 220                 


Thr Glu Lys Lys Pro His Tyr Met Glu Val Leu Glu Met Arg Ala Lys 
225                 230                 235                 240 


Asn Pro Val Pro Gln Leu Arg Lys Phe Lys Thr Asn Val Leu Pro Phe 
                245                 250                 255     


Arg Gln Asn Asp Ser Ser Ser His Cys Gln Lys Ser Gly Ser Pro Ile 
            260                 265                 270         


Ser Ser Glu Glu Arg Arg Arg Arg Asp Lys Gln His Leu Asp Asp Ile 
        275                 280                 285             


Thr Ala Ala Arg Leu Leu Pro Leu His His Met Pro Thr Gln Leu Leu 
    290                 295                 300                 


Ser Ile Glu Glu Ser Leu Ala Leu Gln Lys Gln Gln Lys Gln Asn Tyr 
305                 310                 315                 320 


Glu Glu Met Gln Ala Lys Leu Ala Ala Gln Lys Leu Ala Glu Arg Leu 
                325                 330                 335     


Asn Ile Lys Met Arg Ser Tyr Asn Pro Glu Gly Glu Ser Ser Gly Arg 
            340                 345                 350         


Tyr Arg Glu Val Arg Asp Glu Asp Asp Asp Trp Ser Ser Asp Glu Phe 
        355                 360                 365             


<210>  353
<211>  1603
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (140)..(1081)

<400>  353
cgggacggcc gcgggaaaag gcgcgcggaa ggggtcctgc caccgcgcca cttggcctgc       60

ctccgtcccg ccgcgccact tggcctgcct ccgtcccgcc gcgccacttc gcctgcctcc      120

gtcccccgcc cgccgcgcc atg cct gtg gcc ggc tcg gag ctg ccg cgc cgg       172
                     Met Pro Val Ala Gly Ser Glu Leu Pro Arg Arg          
                     1               5                   10               

ccc ttg ccc ccc gcc gca cag gag cgg gac gcc gag ccg cgt ccg ccg        220
Pro Leu Pro Pro Ala Ala Gln Glu Arg Asp Ala Glu Pro Arg Pro Pro           
            15                  20                  25                    

cac ggg gag ctg cag tac ctg ggg cag atc caa cac atc ctc cgc tgc        268
His Gly Glu Leu Gln Tyr Leu Gly Gln Ile Gln His Ile Leu Arg Cys           
        30                  35                  40                        

ggc gtc agg aag gac gac cgc acg ggc acc ggc acc ctg tcg gta ttc        316
Gly Val Arg Lys Asp Asp Arg Thr Gly Thr Gly Thr Leu Ser Val Phe           
    45                  50                  55                            

ggc atg cag gcg cgc tac agc ctg aga gat gaa ttc cct ctg ctg aca        364
Gly Met Gln Ala Arg Tyr Ser Leu Arg Asp Glu Phe Pro Leu Leu Thr           
60                  65                  70                  75            

acc aaa cgt gtg ttc tgg aag ggt gtt ttg gag gag ttg ctg tgg ttt        412
Thr Lys Arg Val Phe Trp Lys Gly Val Leu Glu Glu Leu Leu Trp Phe           
                80                  85                  90                

atc aag gga tcc aca aat gct aaa gag ctg tct tcc aag gga gtg aaa        460
Ile Lys Gly Ser Thr Asn Ala Lys Glu Leu Ser Ser Lys Gly Val Lys           
            95                  100                 105                   

atc tgg gat gcc aat gga tcc cga gac ttt ttg gac agc ctg gga ttc        508
Ile Trp Asp Ala Asn Gly Ser Arg Asp Phe Leu Asp Ser Leu Gly Phe           
        110                 115                 120                       

tcc acc aga gaa gaa ggg gac ttg ggc cca gtt tat ggc ttc cag tgg        556
Ser Thr Arg Glu Glu Gly Asp Leu Gly Pro Val Tyr Gly Phe Gln Trp           
    125                 130                 135                           

agg cat ttt ggg gca gaa tac aga gat atg gaa tca gat tat tca gga        604
Arg His Phe Gly Ala Glu Tyr Arg Asp Met Glu Ser Asp Tyr Ser Gly           
140                 145                 150                 155           

cag gga gtt gac caa ctg caa aga gtg att gac acc atc aaa acc aac        652
Gln Gly Val Asp Gln Leu Gln Arg Val Ile Asp Thr Ile Lys Thr Asn           
                160                 165                 170               

cct gac gac aga aga atc atc atg tgc gct tgg aat cca aga gat ctt        700
Pro Asp Asp Arg Arg Ile Ile Met Cys Ala Trp Asn Pro Arg Asp Leu           
            175                 180                 185                   

cct ctg atg gcg ctg cct cca tgc cat gcc ctc tgc cag ttc tat gtg        748
Pro Leu Met Ala Leu Pro Pro Cys His Ala Leu Cys Gln Phe Tyr Val           
        190                 195                 200                       

gtg aac agt gag ctg tcc tgc cag ctg tac cag aga tcg gga gac atg        796
Val Asn Ser Glu Leu Ser Cys Gln Leu Tyr Gln Arg Ser Gly Asp Met           
    205                 210                 215                           

ggc ctc ggt gtg cct ttc aac atc gcc agc tac gcc ctg ctc acg tac        844
Gly Leu Gly Val Pro Phe Asn Ile Ala Ser Tyr Ala Leu Leu Thr Tyr           
220                 225                 230                 235           

atg att gcg cac atc acg ggc ctg aag cca ggt gac ttt ata cac act        892
Met Ile Ala His Ile Thr Gly Leu Lys Pro Gly Asp Phe Ile His Thr           
                240                 245                 250               

ttg gga gat gca cat att tac ctg aat cac atc gag cca ctg aaa att        940
Leu Gly Asp Ala His Ile Tyr Leu Asn His Ile Glu Pro Leu Lys Ile           
            255                 260                 265                   

cag ctt cag cga gaa ccc aga cct ttc cca aag ctc agg att ctt cga        988
Gln Leu Gln Arg Glu Pro Arg Pro Phe Pro Lys Leu Arg Ile Leu Arg           
        270                 275                 280                       

aaa gtt gag aaa att gat gac ttc aaa gct gaa gac ttt cag att gaa       1036
Lys Val Glu Lys Ile Asp Asp Phe Lys Ala Glu Asp Phe Gln Ile Glu           
    285                 290                 295                           

ggg tac aat ccg cat cca act att aaa atg gaa atg gct gtt tag           1081
Gly Tyr Asn Pro His Pro Thr Ile Lys Met Glu Met Ala Val                   
300                 305                 310                               

ggtgctttca aaggagctcg aaggatattg tcagtcttta ggggttgggc tggatgccga     1141

ggtaaaagtt ctttttgctc taaaagaaaa aggaactagg tcaaaaatct gtccgtgacc     1201

tatcagttat taatttttaa ggatgttgcc actggcaaat gtaactgtgc cagttctttc     1261

cataataaaa ggctttgagt taactcactg agggtatctg acaatgctga ggttatgaac     1321

aaagtgagga gaatgaaatg tatgtgctct tagcaaaaac atgtatgtgc atttcaatcc     1381

cacgtactta taaagaaggt tggtgaattt cacaagctat ttttggaata tttttagaat     1441

attttaagaa tttcacaagc tattccctca aatctgaggg agctgagtaa caccatcgat     1501

catgatgtag agtgtggtta tgaactttaa agttatagtt gttttatatg ttgctataat     1561

aaagaagtgt tctgcattcg tcaaaaaaaa aaaaaaaaaa aa                        1603


<210>  354
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Pro Val Ala Gly Ser Glu Leu Pro Arg Arg Pro Leu Pro Pro Ala 
1               5                   10                  15      


Ala Gln Glu Arg Asp Ala Glu Pro Arg Pro Pro His Gly Glu Leu Gln 
            20                  25                  30          


Tyr Leu Gly Gln Ile Gln His Ile Leu Arg Cys Gly Val Arg Lys Asp 
        35                  40                  45              


Asp Arg Thr Gly Thr Gly Thr Leu Ser Val Phe Gly Met Gln Ala Arg 
    50                  55                  60                  


Tyr Ser Leu Arg Asp Glu Phe Pro Leu Leu Thr Thr Lys Arg Val Phe 
65                  70                  75                  80  


Trp Lys Gly Val Leu Glu Glu Leu Leu Trp Phe Ile Lys Gly Ser Thr 
                85                  90                  95      


Asn Ala Lys Glu Leu Ser Ser Lys Gly Val Lys Ile Trp Asp Ala Asn 
            100                 105                 110         


Gly Ser Arg Asp Phe Leu Asp Ser Leu Gly Phe Ser Thr Arg Glu Glu 
        115                 120                 125             


Gly Asp Leu Gly Pro Val Tyr Gly Phe Gln Trp Arg His Phe Gly Ala 
    130                 135                 140                 


Glu Tyr Arg Asp Met Glu Ser Asp Tyr Ser Gly Gln Gly Val Asp Gln 
145                 150                 155                 160 


Leu Gln Arg Val Ile Asp Thr Ile Lys Thr Asn Pro Asp Asp Arg Arg 
                165                 170                 175     


Ile Ile Met Cys Ala Trp Asn Pro Arg Asp Leu Pro Leu Met Ala Leu 
            180                 185                 190         


Pro Pro Cys His Ala Leu Cys Gln Phe Tyr Val Val Asn Ser Glu Leu 
        195                 200                 205             


Ser Cys Gln Leu Tyr Gln Arg Ser Gly Asp Met Gly Leu Gly Val Pro 
    210                 215                 220                 


Phe Asn Ile Ala Ser Tyr Ala Leu Leu Thr Tyr Met Ile Ala His Ile 
225                 230                 235                 240 


Thr Gly Leu Lys Pro Gly Asp Phe Ile His Thr Leu Gly Asp Ala His 
                245                 250                 255     


Ile Tyr Leu Asn His Ile Glu Pro Leu Lys Ile Gln Leu Gln Arg Glu 
            260                 265                 270         


Pro Arg Pro Phe Pro Lys Leu Arg Ile Leu Arg Lys Val Glu Lys Ile 
        275                 280                 285             


Asp Asp Phe Lys Ala Glu Asp Phe Gln Ile Glu Gly Tyr Asn Pro His 
    290                 295                 300                 


Pro Thr Ile Lys Met Glu Met Ala Val 
305                 310             


<210>  355
<211>  2054
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (366)..(1262)

<400>  355
cccgacccag cgttttcctt gggattccga cctccccctc agagaagaca ggaggtcggg       60

aaggacctgc agcccagggg cttccaagat gaggcccaga gactcggatt atcaatgcag      120

agaaatctga attcaatgag gatcaagccg cctgtgggaa gctgtgcatc cggagatgtg      180

agtttggggc tgaagaagag tggctgaccc tgtgcccaga ggagttcctg acaggccatt      240

actgggcact gttcgatggg cacggcggtc ctgcagcagc catcttggct gccaacaccc      300

tgcactcctg cttgcgccgg cagctggagg ccgtggtgga aggcttggtg gccactcagc      360

ccccc atg cac ctc aat ggc cgc tgc atc tgc ccc agt gac cct cag ttt      410
      Met His Leu Asn Gly Arg Cys Ile Cys Pro Ser Asp Pro Gln Phe         
      1               5                   10                  15          

gtg gag gaa aag ggc atc agg gca gaa gac ttg gtg atc ggg gca ttg        458
Val Glu Glu Lys Gly Ile Arg Ala Glu Asp Leu Val Ile Gly Ala Leu           
                20                  25                  30                

gag agt gcc ttt cag gaa tgt gat gag gtg atc ggg cgg gag ctg gag        506
Glu Ser Ala Phe Gln Glu Cys Asp Glu Val Ile Gly Arg Glu Leu Glu           
            35                  40                  45                    

gcc tca ggc cag atg ggc ggc tgc aca gcc ctg gtg gct gtg tcc ctg        554
Ala Ser Gly Gln Met Gly Gly Cys Thr Ala Leu Val Ala Val Ser Leu           
        50                  55                  60                        

cag gga aag ctg tac atg gcc aat gct ggg gat agc agg gcc atc ttg        602
Gln Gly Lys Leu Tyr Met Ala Asn Ala Gly Asp Ser Arg Ala Ile Leu           
    65                  70                  75                            

gtg cgg aga gat gag ata cgg cca ctg agc ttc gag ttc acc cca gag        650
Val Arg Arg Asp Glu Ile Arg Pro Leu Ser Phe Glu Phe Thr Pro Glu           
80                  85                  90                  95            

act gag cgg cag cgg atc cag cag ctg gcc ttt gtc tat cct gag ctt        698
Thr Glu Arg Gln Arg Ile Gln Gln Leu Ala Phe Val Tyr Pro Glu Leu           
                100                 105                 110               

ctg gct ggt gag ttc acc cga ctg gag ttc cct cgg cgg ctg aag ggg        746
Leu Ala Gly Glu Phe Thr Arg Leu Glu Phe Pro Arg Arg Leu Lys Gly           
            115                 120                 125                   

gat gac ttg gga cag aag gtt ttg ttc agg gat cac cac atg agt ggc        794
Asp Asp Leu Gly Gln Lys Val Leu Phe Arg Asp His His Met Ser Gly           
        130                 135                 140                       

tgg agc tac aaa cgt gtg gag aaa tcg gat ctc aag tac cca ctg atc        842
Trp Ser Tyr Lys Arg Val Glu Lys Ser Asp Leu Lys Tyr Pro Leu Ile           
    145                 150                 155                           

cat gga cag ggt agg cag gct cgg tta cta gga aca ctg gct gtc tcc        890
His Gly Gln Gly Arg Gln Ala Arg Leu Leu Gly Thr Leu Ala Val Ser           
160                 165                 170                 175           

cgg ggc ctg gga gac cat cag ctc aga gtc ctg gac aca aac atc cag        938
Arg Gly Leu Gly Asp His Gln Leu Arg Val Leu Asp Thr Asn Ile Gln           
                180                 185                 190               

ctc aag ccc ttc ttg ctc tct gtg cca cag gtg act gtg ctg gat gtg        986
Leu Lys Pro Phe Leu Leu Ser Val Pro Gln Val Thr Val Leu Asp Val           
            195                 200                 205                   

gac cag ctg gag cta cag gag gat gat gtg gtt gtc atg gca act gat       1034
Asp Gln Leu Glu Leu Gln Glu Asp Asp Val Val Val Met Ala Thr Asp           
        210                 215                 220                       

gga ctc tgg gat gta ctg tcc aac gag cag gtg gca tgg ctg gtg cgg       1082
Gly Leu Trp Asp Val Leu Ser Asn Glu Gln Val Ala Trp Leu Val Arg           
    225                 230                 235                           

agc ttc ctc cct ggg aac caa gag gac cca cac agg ttc tca aag ctg       1130
Ser Phe Leu Pro Gly Asn Gln Glu Asp Pro His Arg Phe Ser Lys Leu           
240                 245                 250                 255           

gcc cag atg ctg ata cac agc aca cag gga aag gaa gac agt ctc aca       1178
Ala Gln Met Leu Ile His Ser Thr Gln Gly Lys Glu Asp Ser Leu Thr           
                260                 265                 270               

gag gaa ggg cag gtg tcc tac gat gac gtc tct gtg ttc gtg att ccc       1226
Glu Glu Gly Gln Val Ser Tyr Asp Asp Val Ser Val Phe Val Ile Pro           
            275                 280                 285                   

ttg cac agt cag ggc caa gag agc agt gac cac tga ggattcagac            1272
Leu His Ser Gln Gly Gln Glu Ser Ser Asp His                               
        290                 295                                           

actgtatccc agaactgctc tagtgcccgg gtgtggtctg ggcatccctc cagtgtgacc     1332

aagagcaaat cctgcctgcc ctatccctag ccaccgccca gtgctctcac tatccacctc     1392

aacacacatc catctcaaga ggaacattta taccaggcag tcagagctgg aagtgtatgg     1452

agagcccagc ccaccaggtc ctgccttttg cggtgataac cttctctggc agagtgactt     1512

tacaacttaa ctaggaaacc catgtgaggc tcctcagaca ggatcttgaa cagcccaaag     1572

tatcattctc agataggggc acccaagcta agggtattag ccaaagatgc caggatgggt     1632

agctagccca tgtttagatc caggtctcca attcatggtt atcagggcat gtgttcaaca     1692

acccccaaag tccacgcagg tggcttgtag aaacctttgg gcagcctcat gtctgctaaa     1752

acagccatct tcaagacagc ccctgaaaag agaccagttc aggtcctgcc ctgctgttct     1812

ttgctggaga tgaggaacag gtgctggggc taaagtttgg ggtagagcac aagggacaag     1872

aggaactctt ggagttggct gggtgagagg gctctccatt tgctacctgt agtagcctgc     1932

ctcttaactg gttgcttctc cctagttcca gccctgccct ggtctgatgc cccaacactg     1992

cccttgcttt gttttccctg tcacctccct attattaaat gttttctaca gaagaaaaaa     2052

aa                                                                    2054


<210>  356
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  356

Met His Leu Asn Gly Arg Cys Ile Cys Pro Ser Asp Pro Gln Phe Val 
1               5                   10                  15      


Glu Glu Lys Gly Ile Arg Ala Glu Asp Leu Val Ile Gly Ala Leu Glu 
            20                  25                  30          


Ser Ala Phe Gln Glu Cys Asp Glu Val Ile Gly Arg Glu Leu Glu Ala 
        35                  40                  45              


Ser Gly Gln Met Gly Gly Cys Thr Ala Leu Val Ala Val Ser Leu Gln 
    50                  55                  60                  


Gly Lys Leu Tyr Met Ala Asn Ala Gly Asp Ser Arg Ala Ile Leu Val 
65                  70                  75                  80  


Arg Arg Asp Glu Ile Arg Pro Leu Ser Phe Glu Phe Thr Pro Glu Thr 
                85                  90                  95      


Glu Arg Gln Arg Ile Gln Gln Leu Ala Phe Val Tyr Pro Glu Leu Leu 
            100                 105                 110         


Ala Gly Glu Phe Thr Arg Leu Glu Phe Pro Arg Arg Leu Lys Gly Asp 
        115                 120                 125             


Asp Leu Gly Gln Lys Val Leu Phe Arg Asp His His Met Ser Gly Trp 
    130                 135                 140                 


Ser Tyr Lys Arg Val Glu Lys Ser Asp Leu Lys Tyr Pro Leu Ile His 
145                 150                 155                 160 


Gly Gln Gly Arg Gln Ala Arg Leu Leu Gly Thr Leu Ala Val Ser Arg 
                165                 170                 175     


Gly Leu Gly Asp His Gln Leu Arg Val Leu Asp Thr Asn Ile Gln Leu 
            180                 185                 190         


Lys Pro Phe Leu Leu Ser Val Pro Gln Val Thr Val Leu Asp Val Asp 
        195                 200                 205             


Gln Leu Glu Leu Gln Glu Asp Asp Val Val Val Met Ala Thr Asp Gly 
    210                 215                 220                 


Leu Trp Asp Val Leu Ser Asn Glu Gln Val Ala Trp Leu Val Arg Ser 
225                 230                 235                 240 


Phe Leu Pro Gly Asn Gln Glu Asp Pro His Arg Phe Ser Lys Leu Ala 
                245                 250                 255     


Gln Met Leu Ile His Ser Thr Gln Gly Lys Glu Asp Ser Leu Thr Glu 
            260                 265                 270         


Glu Gly Gln Val Ser Tyr Asp Asp Val Ser Val Phe Val Ile Pro Leu 
        275                 280                 285             


His Ser Gln Gly Gln Glu Ser Ser Asp His 
    290                 295             


<210>  357
<211>  3659
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (346)..(2148)

<400>  357
ggaacagtgt ggggcctgga ccgctgggta ggcgcgtcca gcggcctgag caggggaggg       60

taatgaggct gttacgcgcc ttctccgcat cttggcggga gcctgacgcc ccgcttcttc      120

cctaacgggg tgttccaccg gcgcctgccg aggcctaggc ctccgcagcc gccctccgtc      180

tcctcagccc cgacgctgcg cccgctttgt gcgcattttt ctctggggaa actgaggctc      240

cgagtgcgaa agtcagccga ggtcgccccg cccaggacag agaagggctg ggggtcggct      300

gagccgcggc attcccgggc cccgctaggg ctgcagggtc tcagg atg gca gcc tcg      357
                                                  Met Ala Ala Ser         
                                                  1                       

gcg cag gtg tct gtg acc ttt gag gat gtg gct gtg aca ttc acc cag        405
Ala Gln Val Ser Val Thr Phe Glu Asp Val Ala Val Thr Phe Thr Gln           
5                   10                  15                  20            

gag gag tgg gga cag ttg gat gca gcc cag aga acc ttg tat cag gag        453
Glu Glu Trp Gly Gln Leu Asp Ala Ala Gln Arg Thr Leu Tyr Gln Glu           
                25                  30                  35                

gtg atg ctg gag acc tgc gga ctt ctc atg tct ctg ggc tgt cct ttg        501
Val Met Leu Glu Thr Cys Gly Leu Leu Met Ser Leu Gly Cys Pro Leu           
            40                  45                  50                    

ttc aaa cca gag ctg atc tac cag ttg gat cac aga cag gag cta tgg        549
Phe Lys Pro Glu Leu Ile Tyr Gln Leu Asp His Arg Gln Glu Leu Trp           
        55                  60                  65                        

atg gct aca aaa gac ctc tcc caa agc tcc tat cca ggt gac aac aca        597
Met Ala Thr Lys Asp Leu Ser Gln Ser Ser Tyr Pro Gly Asp Asn Thr           
    70                  75                  80                            

aaa ccc aag acc aca gag cct acc ttt tct cac ctg gcc ttg cct gag        645
Lys Pro Lys Thr Thr Glu Pro Thr Phe Ser His Leu Ala Leu Pro Glu           
85                  90                  95                  100           

gaa gtc tta ctc cag gaa caa ctg aca caa gga gcc tca aag aac tcc        693
Glu Val Leu Leu Gln Glu Gln Leu Thr Gln Gly Ala Ser Lys Asn Ser           
                105                 110                 115               

caa tta ggg caa tcc aag gat cag gat ggg cca tct gaa atg caa gaa        741
Gln Leu Gly Gln Ser Lys Asp Gln Asp Gly Pro Ser Glu Met Gln Glu           
            120                 125                 130                   

gtc cac ttg aaa ata ggg ata ggc ccc cag cgg ggg aag ctg ctg gag        789
Val His Leu Lys Ile Gly Ile Gly Pro Gln Arg Gly Lys Leu Leu Glu           
        135                 140                 145                       

aaa atg agt tct gaa cgt gat ggt ttg ggg tca gat gat ggt gta tgt        837
Lys Met Ser Ser Glu Arg Asp Gly Leu Gly Ser Asp Asp Gly Val Cys           
    150                 155                 160                           

aca aag att aca cag aaa caa gtt tca aca gaa ggt gat ctc tat gaa        885
Thr Lys Ile Thr Gln Lys Gln Val Ser Thr Glu Gly Asp Leu Tyr Glu           
165                 170                 175                 180           

tgt gat tca cat gga cca gtt aca gat gcc ttg att cgc gaa gag aaa        933
Cys Asp Ser His Gly Pro Val Thr Asp Ala Leu Ile Arg Glu Glu Lys           
                185                 190                 195               

aat tcc tat aaa tgt gag gaa tgc ggg aaa gtg ttt aaa aag aat gcc        981
Asn Ser Tyr Lys Cys Glu Glu Cys Gly Lys Val Phe Lys Lys Asn Ala           
            200                 205                 210                   

ctc ctt gtt cag cat gaa cgg att cac act caa gtg aag ccc tat gaa       1029
Leu Leu Val Gln His Glu Arg Ile His Thr Gln Val Lys Pro Tyr Glu           
        215                 220                 225                       

tgc aca gag tgt ggg aaa acc ttt agc aag agc act cat ctt ctt cag       1077
Cys Thr Glu Cys Gly Lys Thr Phe Ser Lys Ser Thr His Leu Leu Gln           
    230                 235                 240                           

cac ctc atc atc cac act ggg gag aag ccc tat aag tgc atg gag tgt       1125
His Leu Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Met Glu Cys           
245                 250                 255                 260           

ggg aag gct ttt aac cgc agg tca cac ctc aca cgg cac cag cgg att       1173
Gly Lys Ala Phe Asn Arg Arg Ser His Leu Thr Arg His Gln Arg Ile           
                265                 270                 275               

cac agt gga gag aag cct tat aag tgc agt gaa tgt gga aag gcc ttc       1221
His Ser Gly Glu Lys Pro Tyr Lys Cys Ser Glu Cys Gly Lys Ala Phe           
            280                 285                 290                   

acc cac cgc tcc act ttt gtc ttg cat cac agg agc cac act gga gaa       1269
Thr His Arg Ser Thr Phe Val Leu His His Arg Ser His Thr Gly Glu           
        295                 300                 305                       

aaa ccc ttt gtg tgc aaa gag tgt ggc aaa gcc ttt cga gat agg cca       1317
Lys Pro Phe Val Cys Lys Glu Cys Gly Lys Ala Phe Arg Asp Arg Pro           
    310                 315                 320                           

ggt ttc att cga cac tac atc atc cac acg gga gag aag ccc tat gag       1365
Gly Phe Ile Arg His Tyr Ile Ile His Thr Gly Glu Lys Pro Tyr Glu           
325                 330                 335                 340           

tgc att gag tgt ggg aag gcc ttc aac cgc cgg tca tac ctc acg tgg       1413
Cys Ile Glu Cys Gly Lys Ala Phe Asn Arg Arg Ser Tyr Leu Thr Trp           
                345                 350                 355               

cac caa cag att cac act gga gtg aaa ccc ttt gaa tgc aac gag tgt       1461
His Gln Gln Ile His Thr Gly Val Lys Pro Phe Glu Cys Asn Glu Cys           
            360                 365                 370                   

gga aaa gct ttt tgc gag agt gca gac ctc att caa cac tac att atc       1509
Gly Lys Ala Phe Cys Glu Ser Ala Asp Leu Ile Gln His Tyr Ile Ile           
        375                 380                 385                       

cac act ggg gag aag ccc tat aag tgc atg gag tgt ggg aag gcg ttc       1557
His Thr Gly Glu Lys Pro Tyr Lys Cys Met Glu Cys Gly Lys Ala Phe           
    390                 395                 400                           

aac cgt agg tca cac ctc aag cag cat caa cgg att cac act ggg gag       1605
Asn Arg Arg Ser His Leu Lys Gln His Gln Arg Ile His Thr Gly Glu           
405                 410                 415                 420           

aag cct tat gaa tgc agt gaa tgt gga aag gcc ttc acc cac tgc tcc       1653
Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Thr His Cys Ser           
                425                 430                 435               

act ttt gtc ttg cat aaa agg acc cac aca gga gaa aaa ccc tat gaa       1701
Thr Phe Val Leu His Lys Arg Thr His Thr Gly Glu Lys Pro Tyr Glu           
            440                 445                 450                   

tgc aaa gaa tgt gga aaa gcc ttt agt gat agg gca gac ctc att cgc       1749
Cys Lys Glu Cys Gly Lys Ala Phe Ser Asp Arg Ala Asp Leu Ile Arg           
        455                 460                 465                       

cac ttc agc atc cac act gga gag aaa ccc tat gag tgc gtg gag tgt       1797
His Phe Ser Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Val Glu Cys           
    470                 475                 480                           

gga aag gcc ttc aac cgc agc tca cac ctc acg agg cac caa cag att       1845
Gly Lys Ala Phe Asn Arg Ser Ser His Leu Thr Arg His Gln Gln Ile           
485                 490                 495                 500           

cac act gga gag aaa ccc tat gaa tgc atc cag tgt ggg aaa gcc ttt       1893
His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Gln Cys Gly Lys Ala Phe           
                505                 510                 515               

tgc cgg agc gca aac ctt att cga cac tcc atc att cac act gga gag       1941
Cys Arg Ser Ala Asn Leu Ile Arg His Ser Ile Ile His Thr Gly Glu           
            520                 525                 530                   

aag ccg tat gaa tgc agt gag tgt gga aag gct ttt aat cgc ggc tca       1989
Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Asn Arg Gly Ser           
        535                 540                 545                       

tcc ctc aca cat cat caa agg att cat act ggg aga aac cct acc att       2037
Ser Leu Thr His His Gln Arg Ile His Thr Gly Arg Asn Pro Thr Ile           
    550                 555                 560                           

gta aca gat gtg gga aga cct ttt atg act gca cag act tca gtc aac       2085
Val Thr Asp Val Gly Arg Pro Phe Met Thr Ala Gln Thr Ser Val Asn           
565                 570                 575                 580           

atc cag gaa ctt tta tta ggg aaa gag ttt ttg aat atc acc act gaa       2133
Ile Gln Glu Leu Leu Leu Gly Lys Glu Phe Leu Asn Ile Thr Thr Glu           
                585                 590                 595               

gaa aat ctg tgg tga aagggaacat cttaccatct ggccattcac actgaagaga       2188
Glu Asn Leu Trp                                                           
            600                                                           

aacttcataa gcatcctctc tttgagaaaa cgtgtaatag atgatcattt gtcgtctaaa     2248

caatcaagtt agaaattgaa ccagcctgga gtcttattct ccacctgaga attcacccat     2308

gagagagacc cagtggttgc tatgcactta ggaaaacttt cagccacatc tttcttctta     2368

gtttacagtg aaatattatc tcagggatat tttttttttt tttttgagac ggagtctcgc     2428

tctgtcgccc aggctggagt gcagtggcgg gatctcggct cactgcaagc tccgcctccc     2488

gggttcacgc cattctcctg cctcagcctc ccaagtagct gggactacag gcacccgcca     2548

ctacgcctgg ctaatttttt gtatttttag tagagacggg gtttcaccgt tttagccggg     2608

atggtctcga tctcctgacc tcgtgatccg cccgcctcag cctcccaaag tgctgggatt     2668

acaggcgtga gccaccgcgc ccggccatct cagggatatt taaacaaagg aagaggaaat     2728

atagggaaga gaaagaaacc acagcttctt ttagacttgt ctgacaagcc tatggcaatt     2788

ttgtcgtccc tttgttattt tatgtgggag agggaaatgt ttcagaaacg aaagatctca     2848

tcccctttat ttttctgtgt atgcattcac tgctgcccag tgtcagaaca gttatacaaa     2908

cgagggcttg aaaacatttt gtgaaaactt gcttagtcct gcaacgttct ccactctcga     2968

ggtgcagaag catacatctt tataaaaaat atggaggctt gagttatgaa acacttttat     3028

aaggagataa ggatgtacat atgtttggac acattgtcca cttcagatgc ttgtttaaaa     3088

aaatgtttca ccatgtgtct ttacccaata cacatacttt ttcttgatgt ggatttactt     3148

tttttttttt tttttaagtt ttcctgggat agggatgata gtgtaattgt tcatgcccac     3208

agtaatcctg ggaatcttag ttttttccta tgattgtggt ttctcagctt ctttacctct     3268

cctttgagtt aggtccacct cagttttcta aaggtcaaat taaggccccc ccaaaaatac     3328

agtatgtagc tgaattcctt tgaaagatca tgataaactc agaagaacaa acatagaagg     3388

aatgtcattt ttaatctttt taaagagtgt gtgaaaattc actttaactg gaattttaac     3448

aggcaagccg gcatgcatat atgtagggat gtgtgacttt cacagttgtc accatggact     3508

taggcttgat taaaatgcta cacatttaga gcgttttgta attccttttt tatattttta     3568

agactagatt ttgagccatg tgatagtttt acctcatatt aaatatattg tacagaagta     3628

aaaataatca tgtattcact ttgaactcct c                                    3659


<210>  358
<211>  600
<212>  PRT
<213>  Homo sapiens

<400>  358

Met Ala Ala Ser Ala Gln Val Ser Val Thr Phe Glu Asp Val Ala Val 
1               5                   10                  15      


Thr Phe Thr Gln Glu Glu Trp Gly Gln Leu Asp Ala Ala Gln Arg Thr 
            20                  25                  30          


Leu Tyr Gln Glu Val Met Leu Glu Thr Cys Gly Leu Leu Met Ser Leu 
        35                  40                  45              


Gly Cys Pro Leu Phe Lys Pro Glu Leu Ile Tyr Gln Leu Asp His Arg 
    50                  55                  60                  


Gln Glu Leu Trp Met Ala Thr Lys Asp Leu Ser Gln Ser Ser Tyr Pro 
65                  70                  75                  80  


Gly Asp Asn Thr Lys Pro Lys Thr Thr Glu Pro Thr Phe Ser His Leu 
                85                  90                  95      


Ala Leu Pro Glu Glu Val Leu Leu Gln Glu Gln Leu Thr Gln Gly Ala 
            100                 105                 110         


Ser Lys Asn Ser Gln Leu Gly Gln Ser Lys Asp Gln Asp Gly Pro Ser 
        115                 120                 125             


Glu Met Gln Glu Val His Leu Lys Ile Gly Ile Gly Pro Gln Arg Gly 
    130                 135                 140                 


Lys Leu Leu Glu Lys Met Ser Ser Glu Arg Asp Gly Leu Gly Ser Asp 
145                 150                 155                 160 


Asp Gly Val Cys Thr Lys Ile Thr Gln Lys Gln Val Ser Thr Glu Gly 
                165                 170                 175     


Asp Leu Tyr Glu Cys Asp Ser His Gly Pro Val Thr Asp Ala Leu Ile 
            180                 185                 190         


Arg Glu Glu Lys Asn Ser Tyr Lys Cys Glu Glu Cys Gly Lys Val Phe 
        195                 200                 205             


Lys Lys Asn Ala Leu Leu Val Gln His Glu Arg Ile His Thr Gln Val 
    210                 215                 220                 


Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys Thr Phe Ser Lys Ser Thr 
225                 230                 235                 240 


His Leu Leu Gln His Leu Ile Ile His Thr Gly Glu Lys Pro Tyr Lys 
                245                 250                 255     


Cys Met Glu Cys Gly Lys Ala Phe Asn Arg Arg Ser His Leu Thr Arg 
            260                 265                 270         


His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Ser Glu Cys 
        275                 280                 285             


Gly Lys Ala Phe Thr His Arg Ser Thr Phe Val Leu His His Arg Ser 
    290                 295                 300                 


His Thr Gly Glu Lys Pro Phe Val Cys Lys Glu Cys Gly Lys Ala Phe 
305                 310                 315                 320 


Arg Asp Arg Pro Gly Phe Ile Arg His Tyr Ile Ile His Thr Gly Glu 
                325                 330                 335     


Lys Pro Tyr Glu Cys Ile Glu Cys Gly Lys Ala Phe Asn Arg Arg Ser 
            340                 345                 350         


Tyr Leu Thr Trp His Gln Gln Ile His Thr Gly Val Lys Pro Phe Glu 
        355                 360                 365             


Cys Asn Glu Cys Gly Lys Ala Phe Cys Glu Ser Ala Asp Leu Ile Gln 
    370                 375                 380                 


His Tyr Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Met Glu Cys 
385                 390                 395                 400 


Gly Lys Ala Phe Asn Arg Arg Ser His Leu Lys Gln His Gln Arg Ile 
                405                 410                 415     


His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe 
            420                 425                 430         


Thr His Cys Ser Thr Phe Val Leu His Lys Arg Thr His Thr Gly Glu 
        435                 440                 445             


Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Asp Arg Ala 
    450                 455                 460                 


Asp Leu Ile Arg His Phe Ser Ile His Thr Gly Glu Lys Pro Tyr Glu 
465                 470                 475                 480 


Cys Val Glu Cys Gly Lys Ala Phe Asn Arg Ser Ser His Leu Thr Arg 
                485                 490                 495     


His Gln Gln Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Gln Cys 
            500                 505                 510         


Gly Lys Ala Phe Cys Arg Ser Ala Asn Leu Ile Arg His Ser Ile Ile 
        515                 520                 525             


His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe 
    530                 535                 540                 


Asn Arg Gly Ser Ser Leu Thr His His Gln Arg Ile His Thr Gly Arg 
545                 550                 555                 560 


Asn Pro Thr Ile Val Thr Asp Val Gly Arg Pro Phe Met Thr Ala Gln 
                565                 570                 575     


Thr Ser Val Asn Ile Gln Glu Leu Leu Leu Gly Lys Glu Phe Leu Asn 
            580                 585                 590         


Ile Thr Thr Glu Glu Asn Leu Trp 
        595                 600 


<210>  359
<211>  2171
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (264)..(1667)

<400>  359
gagctcggcg cacctgggct gggcaggtaa gggctggtgc gggacgggga gaggaacctg       60

cagtccctac ttgggtagag ccaggcgccc cttggctaag acgtcgagga gcgtggtagc      120

gacgggtgat cttcgctgcg gacttggttc ggagggacgt ccgcttctgg tggacagatt      180

gagcaaagaa tctttgagcg gtcaagggaa agacaagccg actcttcaga tccctgtgga      240

cacactgcct gctcttccat atc atg gcc ctc cac ccc cgc aga gtc cgg cta      293
                          Met Ala Leu His Pro Arg Arg Val Arg Leu         
                          1               5                   10          

aag ccc tgg ctg gtg gcc cag gtg gat agt ggc ctc tac cct ggg ctc        341
Lys Pro Trp Leu Val Ala Gln Val Asp Ser Gly Leu Tyr Pro Gly Leu           
                15                  20                  25                

atc tgg cta cac agg gac tct aaa cgc ttc cag att ccc tgg aaa cat        389
Ile Trp Leu His Arg Asp Ser Lys Arg Phe Gln Ile Pro Trp Lys His           
            30                  35                  40                    

gcc acc cgg cat agc cct caa caa gaa gag gaa aat acc att ttt aag        437
Ala Thr Arg His Ser Pro Gln Gln Glu Glu Glu Asn Thr Ile Phe Lys           
        45                  50                  55                        

gcc tgg gct gta gag aca ggg aag tac cag gaa ggg gtg gat gac cct        485
Ala Trp Ala Val Glu Thr Gly Lys Tyr Gln Glu Gly Val Asp Asp Pro           
    60                  65                  70                            

gac cca gct aaa tgg aag gcc cag ctg cgc tgt gct ctc aat aag agc        533
Asp Pro Ala Lys Trp Lys Ala Gln Leu Arg Cys Ala Leu Asn Lys Ser           
75                  80                  85                  90            

aga gaa ttc aac ctg atg tat gat ggc acc aag gag gtg ccc atg aac        581
Arg Glu Phe Asn Leu Met Tyr Asp Gly Thr Lys Glu Val Pro Met Asn           
                95                  100                 105               

cca gtg aag ata tat caa gtg tgt gac atc cct cag ccc cag ggc tcg        629
Pro Val Lys Ile Tyr Gln Val Cys Asp Ile Pro Gln Pro Gln Gly Ser           
            110                 115                 120                   

atc att aac cca gga tcc aca ggg tct gct ccc tgg gat gag aag gat        677
Ile Ile Asn Pro Gly Ser Thr Gly Ser Ala Pro Trp Asp Glu Lys Asp           
        125                 130                 135                       

aat gat gtg gat gaa gaa gat gag gaa gat gag ctg gat cag tcg cag        725
Asn Asp Val Asp Glu Glu Asp Glu Glu Asp Glu Leu Asp Gln Ser Gln           
    140                 145                 150                           

cac cat gtt ccc atc cag gac acc ttc ccc ttc ctg aac atc aat ggt        773
His His Val Pro Ile Gln Asp Thr Phe Pro Phe Leu Asn Ile Asn Gly           
155                 160                 165                 170           

tct ccc atg gcg cca gcc agt gtg ggc aat tgc agt gtg ggc aac tgc        821
Ser Pro Met Ala Pro Ala Ser Val Gly Asn Cys Ser Val Gly Asn Cys           
                175                 180                 185               

agc ccg gag gca gtg tgg ccc aaa act gaa ccc ctg gag atg gaa gta        869
Ser Pro Glu Ala Val Trp Pro Lys Thr Glu Pro Leu Glu Met Glu Val           
            190                 195                 200                   

ccc cag gca cct ata cag ccc ttc tat agc tct cca gaa ctg tgg atc        917
Pro Gln Ala Pro Ile Gln Pro Phe Tyr Ser Ser Pro Glu Leu Trp Ile           
        205                 210                 215                       

agc tct ctc cca atg act gac ctg gac atc aag ttt cag tac cgt ggg        965
Ser Ser Leu Pro Met Thr Asp Leu Asp Ile Lys Phe Gln Tyr Arg Gly           
    220                 225                 230                           

aag gag tac ggg cag acc atg acc gtg agc aac cct cag ggc tgc cga       1013
Lys Glu Tyr Gly Gln Thr Met Thr Val Ser Asn Pro Gln Gly Cys Arg           
235                 240                 245                 250           

ctc ttc tat ggg gac ctg ggt ccc atg cct gac cag gag gag ctc ttt       1061
Leu Phe Tyr Gly Asp Leu Gly Pro Met Pro Asp Gln Glu Glu Leu Phe           
                255                 260                 265               

ggt ccc gtc agc ctg gag cag gtc aaa ttc cca ggt cct gag cat att       1109
Gly Pro Val Ser Leu Glu Gln Val Lys Phe Pro Gly Pro Glu His Ile           
            270                 275                 280                   

acc aat gag aag cag aag ctg ttc act agc aag ctg ctg gac gtc atg       1157
Thr Asn Glu Lys Gln Lys Leu Phe Thr Ser Lys Leu Leu Asp Val Met           
        285                 290                 295                       

gac aga gga ctg atc ctg gag gtc agc ggt cat gcc att tat gcc atc       1205
Asp Arg Gly Leu Ile Leu Glu Val Ser Gly His Ala Ile Tyr Ala Ile           
    300                 305                 310                           

agg ctg tgc cag tgc aag gtg tac tgg tct ggg cca tgt gcc cca tca       1253
Arg Leu Cys Gln Cys Lys Val Tyr Trp Ser Gly Pro Cys Ala Pro Ser           
315                 320                 325                 330           

ctt gtt gct ccc aac ctg att gag aga caa aag aag gtc aag cta ttt       1301
Leu Val Ala Pro Asn Leu Ile Glu Arg Gln Lys Lys Val Lys Leu Phe           
                335                 340                 345               

tgt ctg gaa aca ttc ctt agc gat ctc att gcc cac cag aaa gga cag       1349
Cys Leu Glu Thr Phe Leu Ser Asp Leu Ile Ala His Gln Lys Gly Gln           
            350                 355                 360                   

ata gag aag cag cca ccg ttt gag atc tac tta tgc ttt ggg gaa gaa       1397
Ile Glu Lys Gln Pro Pro Phe Glu Ile Tyr Leu Cys Phe Gly Glu Glu           
        365                 370                 375                       

tgg cca gat ggg aaa cca ttg gaa agg aaa ctc atc ttg gtt cag gtc       1445
Trp Pro Asp Gly Lys Pro Leu Glu Arg Lys Leu Ile Leu Val Gln Val           
    380                 385                 390                           

att cca gta gtg gct cgg atg atc tac gag atg ttt tct ggt gat ttc       1493
Ile Pro Val Val Ala Arg Met Ile Tyr Glu Met Phe Ser Gly Asp Phe           
395                 400                 405                 410           

aca cga tcc ttt gat agt ggc agt gtc cgc ctg cag atc tca acc cca       1541
Thr Arg Ser Phe Asp Ser Gly Ser Val Arg Leu Gln Ile Ser Thr Pro           
                415                 420                 425               

gac atc aag gat aac atc gtt gct cag ctg aag cag ctg tac cgc atc       1589
Asp Ile Lys Asp Asn Ile Val Ala Gln Leu Lys Gln Leu Tyr Arg Ile           
            430                 435                 440                   

ctt caa acc cag gag agc tgg cag ccc atg cag ccc acc ccc agc atg       1637
Leu Gln Thr Gln Glu Ser Trp Gln Pro Met Gln Pro Thr Pro Ser Met           
        445                 450                 455                       

caa ctg ccc cct gcc ctg cct ccc cag taa ttgtgaatgc catcttcttc         1687
Gln Leu Pro Pro Ala Leu Pro Pro Gln                                       
    460                 465                                               

cttctctttt ttataatatt gtacatatgg atttttttat tgtttagatt taaccagctt     1747

ttaaatctct cttttctcta acagtgttag aagtttgtga ttctccaaat atgcctagat     1807

ttaaagctga tttaatttat ggaaaaatca cccttcagac tttgcttttc tttttcaaat     1867

ctcctaatgg tagtatgata tagcatagta gaaggagatt tggcctggga gtttggacac     1927

caaagttcta gctgcagctt tgcttccaat gtgaccttga acaagtcctt taacctctgg     1987

gcttcagatt tattgcttat aaagtgaaga gattggagta gtgcctgaaa ttgcatccag     2047

ctttagaacg gactcaatga ccttcttcta cttgtacaag gctaaactgc ctggaacaga     2107

atccttctgc attgttcttg taccacattt ttccttggtt ttgttaaagt ttcctcaagc     2167

acta                                                                  2171


<210>  360
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  360

Met Ala Leu His Pro Arg Arg Val Arg Leu Lys Pro Trp Leu Val Ala 
1               5                   10                  15      


Gln Val Asp Ser Gly Leu Tyr Pro Gly Leu Ile Trp Leu His Arg Asp 
            20                  25                  30          


Ser Lys Arg Phe Gln Ile Pro Trp Lys His Ala Thr Arg His Ser Pro 
        35                  40                  45              


Gln Gln Glu Glu Glu Asn Thr Ile Phe Lys Ala Trp Ala Val Glu Thr 
    50                  55                  60                  


Gly Lys Tyr Gln Glu Gly Val Asp Asp Pro Asp Pro Ala Lys Trp Lys 
65                  70                  75                  80  


Ala Gln Leu Arg Cys Ala Leu Asn Lys Ser Arg Glu Phe Asn Leu Met 
                85                  90                  95      


Tyr Asp Gly Thr Lys Glu Val Pro Met Asn Pro Val Lys Ile Tyr Gln 
            100                 105                 110         


Val Cys Asp Ile Pro Gln Pro Gln Gly Ser Ile Ile Asn Pro Gly Ser 
        115                 120                 125             


Thr Gly Ser Ala Pro Trp Asp Glu Lys Asp Asn Asp Val Asp Glu Glu 
    130                 135                 140                 


Asp Glu Glu Asp Glu Leu Asp Gln Ser Gln His His Val Pro Ile Gln 
145                 150                 155                 160 


Asp Thr Phe Pro Phe Leu Asn Ile Asn Gly Ser Pro Met Ala Pro Ala 
                165                 170                 175     


Ser Val Gly Asn Cys Ser Val Gly Asn Cys Ser Pro Glu Ala Val Trp 
            180                 185                 190         


Pro Lys Thr Glu Pro Leu Glu Met Glu Val Pro Gln Ala Pro Ile Gln 
        195                 200                 205             


Pro Phe Tyr Ser Ser Pro Glu Leu Trp Ile Ser Ser Leu Pro Met Thr 
    210                 215                 220                 


Asp Leu Asp Ile Lys Phe Gln Tyr Arg Gly Lys Glu Tyr Gly Gln Thr 
225                 230                 235                 240 


Met Thr Val Ser Asn Pro Gln Gly Cys Arg Leu Phe Tyr Gly Asp Leu 
                245                 250                 255     


Gly Pro Met Pro Asp Gln Glu Glu Leu Phe Gly Pro Val Ser Leu Glu 
            260                 265                 270         


Gln Val Lys Phe Pro Gly Pro Glu His Ile Thr Asn Glu Lys Gln Lys 
        275                 280                 285             


Leu Phe Thr Ser Lys Leu Leu Asp Val Met Asp Arg Gly Leu Ile Leu 
    290                 295                 300                 


Glu Val Ser Gly His Ala Ile Tyr Ala Ile Arg Leu Cys Gln Cys Lys 
305                 310                 315                 320 


Val Tyr Trp Ser Gly Pro Cys Ala Pro Ser Leu Val Ala Pro Asn Leu 
                325                 330                 335     


Ile Glu Arg Gln Lys Lys Val Lys Leu Phe Cys Leu Glu Thr Phe Leu 
            340                 345                 350         


Ser Asp Leu Ile Ala His Gln Lys Gly Gln Ile Glu Lys Gln Pro Pro 
        355                 360                 365             


Phe Glu Ile Tyr Leu Cys Phe Gly Glu Glu Trp Pro Asp Gly Lys Pro 
    370                 375                 380                 


Leu Glu Arg Lys Leu Ile Leu Val Gln Val Ile Pro Val Val Ala Arg 
385                 390                 395                 400 


Met Ile Tyr Glu Met Phe Ser Gly Asp Phe Thr Arg Ser Phe Asp Ser 
                405                 410                 415     


Gly Ser Val Arg Leu Gln Ile Ser Thr Pro Asp Ile Lys Asp Asn Ile 
            420                 425                 430         


Val Ala Gln Leu Lys Gln Leu Tyr Arg Ile Leu Gln Thr Gln Glu Ser 
        435                 440                 445             


Trp Gln Pro Met Gln Pro Thr Pro Ser Met Gln Leu Pro Pro Ala Leu 
    450                 455                 460                 


Pro Pro Gln 
465         


<210>  361
<211>  2258
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (393)..(956)

<400>  361
cctgcctggg tgggtgtcct gtgacttgac agtggctccc ccagccccaa agccagcccc       60

cttcttctgt gacttagtct gttgtagtgg tgagctgaca catccaggtg tgaccgttgc      120

tgaaaacttg tgccccctct gtggtatgcc cctgccctgt tctataaata gctataaatt      180

atcatatata tacacataca caaactcaca cacacacaca catatatata tatacacata      240

tacatgtggt cgactgcctc gcctctagca ctgggaatca gtccccgtgc tgtgcttgtg      300

gagtcttgta gcccagcaag aggaagctgt ctcctgacat cgcccctcca aagtgcacca      360

cctccagtga gcttccggga catgcgcggc ct atg gac agc cag ccc ccg cca        413
                                    Met Asp Ser Gln Pro Pro Pro           
                                    1               5                     

tcc ctc ccg ccc ttc tgg cca agc atg gcg gtg ctg tgc agg cag ctg        461
Ser Leu Pro Pro Phe Trp Pro Ser Met Ala Val Leu Cys Arg Gln Leu           
        10                  15                  20                        

tgt ggc ctg aca gtc tct acc agt cct gct gtc cct cgg ctg aga aac        509
Cys Gly Leu Thr Val Ser Thr Ser Pro Ala Val Pro Arg Leu Arg Asn           
    25                  30                  35                            

cca ttt ctg aat gac aga gaa tgt gtc ctc tgc tgg ctg tgt tct cta        557
Pro Phe Leu Asn Asp Arg Glu Cys Val Leu Cys Trp Leu Cys Ser Leu           
40                  45                  50                  55            

tgg agc tca ggg gag gga aga ggc caa gcc att ttt agg gtg ctg ttg        605
Trp Ser Ser Gly Glu Gly Arg Gly Gln Ala Ile Phe Arg Val Leu Leu           
                60                  65                  70                

gca gca gtg aaa agg tca cac cct ttt caa ggg aca ctt ttc ctg gaa        653
Ala Ala Val Lys Arg Ser His Pro Phe Gln Gly Thr Leu Phe Leu Glu           
            75                  80                  85                    

agt ccc tgg agc tta gct ggc tct tat tct gtg aag ccg gct ctg gcc        701
Ser Pro Trp Ser Leu Ala Gly Ser Tyr Ser Val Lys Pro Ala Leu Ala           
        90                  95                  100                       

agt agg gca cag ggc cct gaa ctc agc ctg gaa gga gcc tgt ggg gca        749
Ser Arg Ala Gln Gly Pro Glu Leu Ser Leu Glu Gly Ala Cys Gly Ala           
    105                 110                 115                           

gcc ggc act ctg gag gga cag aca ggc cac ccg gtg cag aca gga gag        797
Ala Gly Thr Leu Glu Gly Gln Thr Gly His Pro Val Gln Thr Gly Glu           
120                 125                 130                 135           

gga ggc agg ggg acg gaa tgg aag aca cgt ggg gtg gat gga agt cag        845
Gly Gly Arg Gly Thr Glu Trp Lys Thr Arg Gly Val Asp Gly Ser Gln           
                140                 145                 150               

tgc cct tgg gca ctg gta tct gtc ttc ctg acc aca gct aga tca ggc        893
Cys Pro Trp Ala Leu Val Ser Val Phe Leu Thr Thr Ala Arg Ser Gly           
            155                 160                 165                   

ttc tca acc tgt tgg ctc tca ggg ccg gac tat act cca gag gcg cca        941
Phe Ser Thr Cys Trp Leu Ser Gly Pro Asp Tyr Thr Pro Glu Ala Pro           
        170                 175                 180                       

tgg cag tcc tcg tga aatccaccag gtatcaccag gcagcataca ggtaacaggc        996
Trp Gln Ser Ser                                                           
    185                                                                   

ctggaagatt ccccacagcc cagctggaca tgctgagaca ctctggggct cctcattgag     1056

tgggaaaaac tgcaggaccc agtgagggaa acacgaacat gccaggccga gcagtatggc     1116

taaatccatt tattccaaaa tcaaaagcga accaaaacaa aaacaaaaaa acaaaacaaa     1176

acaaaaaagg ggtcccatca ccagggagcc atgacgccat ccccaccccc atcatcgctc     1236

ctatgctaac aatgaataag tttcccagcc gcgaataatt ataagaacct cttcctcata     1296

tgccagctgc aacctccgct aggtacaata cagaatgtta cacagctaca gtatgtacac     1356

gggggaaggg gggccacccc cagcagcctg tgccctggcc tggtctacag ttaactccac     1416

tgtcccgcct cagctgcctc tctgagtaag aagatgggag cccccctgag ggaaaagttg     1476

ctttggtgag agtaagaagg ccgtcagacc tcctccaaac aaaccaactc caccaacctc     1536

tggctcttaa ataacaaaca tcatcatcca gaaatgtaag gactcagcct tggtcaaggt     1596

ggtaaagggt ctgtttgtct ccctccatta gacaggggtc ttgtcttgct accctaatgg     1656

taaagggctg actggggagg ggttgtaggg acatggtggg ggtgaagact ccagacccac     1716

ttctccaggc ttatgctgac aggggcctgc ttttatttat ttttattttt atcccatgac     1776

tttttttaaa tcctgtaact aatttttcat aactttttaa aataactttt cataaaactt     1836

tttttttact ttttttccac aacttttttt tgccactttt ccacagtatt tttttatcct     1896

gtaacttttt catcccacaa ctttaattcc tgttaacttt tttagtttgt gttcttttaa     1956

taaacacact tacatagtta caattttgta agaataaaaa ccgattacct catgccaagc     2016

atgccgagaa tttgcagagt ctcaataccc aatactatag ttttcaagac acacaaaatt     2076

tttaggcaaa acagcacctt gaaacaattt aataatgtat tacattacag tagcatcaca     2136

gcagcagtca ataatgccac tttagacaaa aatcagtatt tccattatgc attctgtgta     2196

taagaattca taaatcggta aaagtcattc taagaaaact tggcaaatac agctttggac     2256

tg                                                                    2258


<210>  362
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  362

Met Asp Ser Gln Pro Pro Pro Ser Leu Pro Pro Phe Trp Pro Ser Met 
1               5                   10                  15      


Ala Val Leu Cys Arg Gln Leu Cys Gly Leu Thr Val Ser Thr Ser Pro 
            20                  25                  30          


Ala Val Pro Arg Leu Arg Asn Pro Phe Leu Asn Asp Arg Glu Cys Val 
        35                  40                  45              


Leu Cys Trp Leu Cys Ser Leu Trp Ser Ser Gly Glu Gly Arg Gly Gln 
    50                  55                  60                  


Ala Ile Phe Arg Val Leu Leu Ala Ala Val Lys Arg Ser His Pro Phe 
65                  70                  75                  80  


Gln Gly Thr Leu Phe Leu Glu Ser Pro Trp Ser Leu Ala Gly Ser Tyr 
                85                  90                  95      


Ser Val Lys Pro Ala Leu Ala Ser Arg Ala Gln Gly Pro Glu Leu Ser 
            100                 105                 110         


Leu Glu Gly Ala Cys Gly Ala Ala Gly Thr Leu Glu Gly Gln Thr Gly 
        115                 120                 125             


His Pro Val Gln Thr Gly Glu Gly Gly Arg Gly Thr Glu Trp Lys Thr 
    130                 135                 140                 


Arg Gly Val Asp Gly Ser Gln Cys Pro Trp Ala Leu Val Ser Val Phe 
145                 150                 155                 160 


Leu Thr Thr Ala Arg Ser Gly Phe Ser Thr Cys Trp Leu Ser Gly Pro 
                165                 170                 175     


Asp Tyr Thr Pro Glu Ala Pro Trp Gln Ser Ser 
            180                 185         


<210>  363
<211>  2300
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (272)..(1840)

<400>  363
attgtgttct gactgcgatg tggcgcttgc gatctctcgc cgccggcaga ggctcctcga       60

agagcgacac ggggctgacc aggcacggtg gtcaaagccg cagagggaga gcgggagcgg      120

tcgtgaggtc gtctggggag aagggcggag gcaaagccga ggagcaggtg tgtggaccct      180

tctagcctga ggagtcctgc aggtgtgaag ctccacacct gcctccatag cactttgcct      240

gtccctaaga gggctcatcg gagaagaaag a atg gct gtc agc cac ctg cca         292
                                   Met Ala Val Ser His Leu Pro            
                                   1               5                      

acc atg gtc cag gaa tcg gtg acc ttc aag gat gtg gct ata ctg ttc        340
Thr Met Val Gln Glu Ser Val Thr Phe Lys Asp Val Ala Ile Leu Phe           
        10                  15                  20                        

acc cag gag gag tgg ggg cag ctg agc ccc gcc cag agg gcc ctg tac        388
Thr Gln Glu Glu Trp Gly Gln Leu Ser Pro Ala Gln Arg Ala Leu Tyr           
    25                  30                  35                            

agg gac gtg atg ctg gag aac tac agc aac ctg gtc tca ctg gga ctc        436
Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Leu Gly Leu           
40                  45                  50                  55            

tta gga ccc aaa cca gat acg ttt tcc cag cta gaa aaa agg gaa gtg        484
Leu Gly Pro Lys Pro Asp Thr Phe Ser Gln Leu Glu Lys Arg Glu Val           
                60                  65                  70                

tgg atg cca gag gac acc cct gga ggc ttc tgt ctt gac tgg atg act        532
Trp Met Pro Glu Asp Thr Pro Gly Gly Phe Cys Leu Asp Trp Met Thr           
            75                  80                  85                    

atg cct gcc agt aag aaa tct act gtc aag gca gag att cct gaa gaa        580
Met Pro Ala Ser Lys Lys Ser Thr Val Lys Ala Glu Ile Pro Glu Glu           
        90                  95                  100                       

gaa ttg gat caa tgg aca ata aag gaa aga ttc agt agc agt agt cac        628
Glu Leu Asp Gln Trp Thr Ile Lys Glu Arg Phe Ser Ser Ser Ser His           
    105                 110                 115                           

tgg aag tgt gct agc ctg ctg gag tgg caa tgt gga ggc cag gag atc        676
Trp Lys Cys Ala Ser Leu Leu Glu Trp Gln Cys Gly Gly Gln Glu Ile           
120                 125                 130                 135           

agt ttg cag cga gtg gta ctc act cac ccc aac acc cca tca cag gaa        724
Ser Leu Gln Arg Val Val Leu Thr His Pro Asn Thr Pro Ser Gln Glu           
                140                 145                 150               

tat gat gaa tcc ggg agc act atg agc tca tct ctt cac agt gat caa        772
Tyr Asp Glu Ser Gly Ser Thr Met Ser Ser Ser Leu His Ser Asp Gln           
            155                 160                 165                   

agt cag gga ttt caa cct agc aaa aat gcc ttt gag tgt agt gag tgt        820
Ser Gln Gly Phe Gln Pro Ser Lys Asn Ala Phe Glu Cys Ser Glu Cys           
        170                 175                 180                       

gga aaa gtc ttc tct aag agt tca act ctt aat aaa cat cag aaa att        868
Gly Lys Val Phe Ser Lys Ser Ser Thr Leu Asn Lys His Gln Lys Ile           
    185                 190                 195                           

cat aat gaa aaa aat gca aat cag aaa att cat att aag gag aaa aga        916
His Asn Glu Lys Asn Ala Asn Gln Lys Ile His Ile Lys Glu Lys Arg           
200                 205                 210                 215           

tat gaa tgt aga gaa tgt ggg aaa gcc ttt cac cag agt acg cac ctt        964
Tyr Glu Cys Arg Glu Cys Gly Lys Ala Phe His Gln Ser Thr His Leu           
                220                 225                 230               

atc cat cac caa aga att cac act ggc gag aaa ccc tat gaa tgt aag       1012
Ile His His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys           
            235                 240                 245                   

gaa tgt ggc aag gcc ttc tca gtg agc tcc tca ctt acg tac cat cag       1060
Glu Cys Gly Lys Ala Phe Ser Val Ser Ser Ser Leu Thr Tyr His Gln           
        250                 255                 260                       

aaa att cat act gga gag aag cct ttt gaa tgc aac tta tgt gga aaa       1108
Lys Ile His Thr Gly Glu Lys Pro Phe Glu Cys Asn Leu Cys Gly Lys           
    265                 270                 275                           

gct ttt atc cga aat ata cac ctt gcc cat cat cat aga ata cat act       1156
Ala Phe Ile Arg Asn Ile His Leu Ala His His His Arg Ile His Thr           
280                 285                 290                 295           

gga gag aaa cct ttt aaa tgt aac att tgt gaa aaa gcc ttt gtg tgc       1204
Gly Glu Lys Pro Phe Lys Cys Asn Ile Cys Glu Lys Ala Phe Val Cys           
                300                 305                 310               

agg gca cac ctt acc aaa cac cag aat atc cac agt gga gag aaa ccc       1252
Arg Ala His Leu Thr Lys His Gln Asn Ile His Ser Gly Glu Lys Pro           
            315                 320                 325                   

tat aaa tgc aat gaa tgt gga aaa gcc ttt aat cag agt aca agt ttc       1300
Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Asn Gln Ser Thr Ser Phe           
        330                 335                 340                       

ctt cag cat cag aga att cac act gga gag aaa ccc ttt gaa tgt aat       1348
Leu Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys Asn           
    345                 350                 355                           

gaa tgt ggg aag gcc ttc agg gtg aac tct tcc ctt act gaa cat cag       1396
Glu Cys Gly Lys Ala Phe Arg Val Asn Ser Ser Leu Thr Glu His Gln           
360                 365                 370                 375           

aga att cat act gga gag aaa cct tat aaa tgt aat gaa tgt ggg aaa       1444
Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys           
                380                 385                 390               

gct ttc agg gat aat tca tcc ttt gca cga cat cgg aaa att cac act       1492
Ala Phe Arg Asp Asn Ser Ser Phe Ala Arg His Arg Lys Ile His Thr           
            395                 400                 405                   

gga gag aaa cct tac aga tgt ggc ttg tgt gag aaa gcc ttt cgg gac       1540
Gly Glu Lys Pro Tyr Arg Cys Gly Leu Cys Glu Lys Ala Phe Arg Asp           
        410                 415                 420                       

caa tca gca cta gcc caa cat cag aga att cat act ggg gaa aaa cct       1588
Gln Ser Ala Leu Ala Gln His Gln Arg Ile His Thr Gly Glu Lys Pro           
    425                 430                 435                           

tat aca tgt aac ata tgt gaa aaa gcc ttc agt gac cat tca gcc ctt       1636
Tyr Thr Cys Asn Ile Cys Glu Lys Ala Phe Ser Asp His Ser Ala Leu           
440                 445                 450                 455           

acc caa cat aag aga att cat act agg gaa aaa cct tac aaa tgt aaa       1684
Thr Gln His Lys Arg Ile His Thr Arg Glu Lys Pro Tyr Lys Cys Lys           
                460                 465                 470               

atc tgt gag aaa gcc ttt atc cga agc act cac ctg act caa cat cag       1732
Ile Cys Glu Lys Ala Phe Ile Arg Ser Thr His Leu Thr Gln His Gln           
            475                 480                 485                   

agg att cac aca gga gag aaa ccc tat aaa tgt aat aaa tgt ggg aaa       1780
Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Lys Cys Gly Lys           
        490                 495                 500                       

gct ttt aac cag act gca aac ctc att cag cat cag aga cat cat att       1828
Ala Phe Asn Gln Thr Ala Asn Leu Ile Gln His Gln Arg His His Ile           
    505                 510                 515                           

gga gag aag tga tatgaatgca gtttgtatgg aagacctttg agactgagta           1880
Gly Glu Lys                                                               
520                                                                       

gatgaattat tgaatgtgag ataatccgtt ctagagaata actatgaaag cttgcatcaa     1940

gatagtcact ttatttactg agggtcaggt ttcacagtgt catggggttt gggcatttaa     2000

gaatggcaaa cactcggctg ggcacggtgg ctcacgtctg taatctttgg gagcactttg     2060

ggaggccgag gtgggcggat cgcgaggtca ggggatcggg accatcctgg ctaacagggt     2120

gaagccccat cgctactaga aatgtagaaa attacccggg catggtggtg ggcgcctgtg     2180

gtcccggctg ctcgggaggc tgaggcagga gaatggcatg aacccgggag gcggaggttg     2240

cagtgagccg agatcgtgcc actgcgctcc agcctgggcg acagagcaag actcagtctc     2300


<210>  364
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  364

Met Ala Val Ser His Leu Pro Thr Met Val Gln Glu Ser Val Thr Phe 
1               5                   10                  15      


Lys Asp Val Ala Ile Leu Phe Thr Gln Glu Glu Trp Gly Gln Leu Ser 
            20                  25                  30          


Pro Ala Gln Arg Ala Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser 
        35                  40                  45              


Asn Leu Val Ser Leu Gly Leu Leu Gly Pro Lys Pro Asp Thr Phe Ser 
    50                  55                  60                  


Gln Leu Glu Lys Arg Glu Val Trp Met Pro Glu Asp Thr Pro Gly Gly 
65                  70                  75                  80  


Phe Cys Leu Asp Trp Met Thr Met Pro Ala Ser Lys Lys Ser Thr Val 
                85                  90                  95      


Lys Ala Glu Ile Pro Glu Glu Glu Leu Asp Gln Trp Thr Ile Lys Glu 
            100                 105                 110         


Arg Phe Ser Ser Ser Ser His Trp Lys Cys Ala Ser Leu Leu Glu Trp 
        115                 120                 125             


Gln Cys Gly Gly Gln Glu Ile Ser Leu Gln Arg Val Val Leu Thr His 
    130                 135                 140                 


Pro Asn Thr Pro Ser Gln Glu Tyr Asp Glu Ser Gly Ser Thr Met Ser 
145                 150                 155                 160 


Ser Ser Leu His Ser Asp Gln Ser Gln Gly Phe Gln Pro Ser Lys Asn 
                165                 170                 175     


Ala Phe Glu Cys Ser Glu Cys Gly Lys Val Phe Ser Lys Ser Ser Thr 
            180                 185                 190         


Leu Asn Lys His Gln Lys Ile His Asn Glu Lys Asn Ala Asn Gln Lys 
        195                 200                 205             


Ile His Ile Lys Glu Lys Arg Tyr Glu Cys Arg Glu Cys Gly Lys Ala 
    210                 215                 220                 


Phe His Gln Ser Thr His Leu Ile His His Gln Arg Ile His Thr Gly 
225                 230                 235                 240 


Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Val Ser 
                245                 250                 255     


Ser Ser Leu Thr Tyr His Gln Lys Ile His Thr Gly Glu Lys Pro Phe 
            260                 265                 270         


Glu Cys Asn Leu Cys Gly Lys Ala Phe Ile Arg Asn Ile His Leu Ala 
        275                 280                 285             


His His His Arg Ile His Thr Gly Glu Lys Pro Phe Lys Cys Asn Ile 
    290                 295                 300                 


Cys Glu Lys Ala Phe Val Cys Arg Ala His Leu Thr Lys His Gln Asn 
305                 310                 315                 320 


Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala 
                325                 330                 335     


Phe Asn Gln Ser Thr Ser Phe Leu Gln His Gln Arg Ile His Thr Gly 
            340                 345                 350         


Glu Lys Pro Phe Glu Cys Asn Glu Cys Gly Lys Ala Phe Arg Val Asn 
        355                 360                 365             


Ser Ser Leu Thr Glu His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr 
    370                 375                 380                 


Lys Cys Asn Glu Cys Gly Lys Ala Phe Arg Asp Asn Ser Ser Phe Ala 
385                 390                 395                 400 


Arg His Arg Lys Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Gly Leu 
                405                 410                 415     


Cys Glu Lys Ala Phe Arg Asp Gln Ser Ala Leu Ala Gln His Gln Arg 
            420                 425                 430         


Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Asn Ile Cys Glu Lys Ala 
        435                 440                 445             


Phe Ser Asp His Ser Ala Leu Thr Gln His Lys Arg Ile His Thr Arg 
    450                 455                 460                 


Glu Lys Pro Tyr Lys Cys Lys Ile Cys Glu Lys Ala Phe Ile Arg Ser 
465                 470                 475                 480 


Thr His Leu Thr Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr 
                485                 490                 495     


Lys Cys Asn Lys Cys Gly Lys Ala Phe Asn Gln Thr Ala Asn Leu Ile 
            500                 505                 510         


Gln His Gln Arg His His Ile Gly Glu Lys 
        515                 520         


<210>  365
<211>  1849
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (62)..(1063)

<400>  365
gcacagtatc tgggtccagc ctgcagccct agggtccagt tcagagtctg tcatctgaac       60

c atg agg atc tgg tgg ctt ctg ctt gcc att gaa atc tgc aca ggg aac      109
  Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu Ile Cys Thr Gly Asn         
  1               5                   10                  15              

ata aac tca cag gac acc tgc agg caa ggg cac cct gga atc cct ggg        157
Ile Asn Ser Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly           
            20                  25                  30                    

aac ccc ggt cac aat ggt ctg cct gga aga gat gga cga gac gga gcg        205
Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala           
        35                  40                  45                        

aag ggt gac aaa ggc gat gca gga gaa cca gga cgt cct ggc agc ccg        253
Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro           
    50                  55                  60                            

ggg aag gat ggg acg agt gga gag aag gga gaa cga gga gca gat gga        301
Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly           
65                  70                  75                  80            

aaa gtt gaa gca aaa ggc atc aaa ggt gat caa ggc tca aga gga tcc        349
Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser           
                85                  90                  95                

cca gga aaa cat ggc ccc aag ggg ctt gca ggg ccc atg gga gag aag        397
Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys           
            100                 105                 110                   

ggc ctc cga gga gag act ggg cct cag ggg cag aag ggg aat aag ggt        445
Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly           
        115                 120                 125                       

gac gtg ggt ccc act ggt cct gag ggg cca agg ggc aac att ggg cct        493
Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro           
    130                 135                 140                           

ttg ggc cca act ggt tta ccg ggc ccc atg ggc cct att gga aag cct        541
Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro           
145                 150                 155                 160           

ggt ccc aaa gga gaa gct gga ccc acg ggg ccc cag ggt gag cca gga        589
Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly           
                165                 170                 175               

gtc cgg gga ata aga ggc tgg aaa gga gat cga gga gag aaa ggg aaa        637
Val Arg Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu Lys Gly Lys           
            180                 185                 190                   

atc ggt gag act cta gtc ttg cca aaa agt gct ttc act gtg ggg ctc        685
Ile Gly Glu Thr Leu Val Leu Pro Lys Ser Ala Phe Thr Val Gly Leu           
        195                 200                 205                       

acg gtg ctg agc aag ttt cct tct tca gat atg ccc att aaa ttt gat        733
Thr Val Leu Ser Lys Phe Pro Ser Ser Asp Met Pro Ile Lys Phe Asp           
    210                 215                 220                           

aag atc ctg tat aac gaa ttc aac cat tat gat aca gca gcg ggg aaa        781
Lys Ile Leu Tyr Asn Glu Phe Asn His Tyr Asp Thr Ala Ala Gly Lys           
225                 230                 235                 240           

ttc acg tgc cac att gct ggg gtc tat tac ttc acc tac cac atc act        829
Phe Thr Cys His Ile Ala Gly Val Tyr Tyr Phe Thr Tyr His Ile Thr           
                245                 250                 255               

gtt ttc tcc agg aat gtt cag gtg tct ttg gtc aaa aat gga gta aaa        877
Val Phe Ser Arg Asn Val Gln Val Ser Leu Val Lys Asn Gly Val Lys           
            260                 265                 270                   

ata ctg cac acc aaa gat gct tac atg agc tct gag gac cag gcc tct        925
Ile Leu His Thr Lys Asp Ala Tyr Met Ser Ser Glu Asp Gln Ala Ser           
        275                 280                 285                       

ggc ggc att gtc ctg cag ctg aag ctc ggg gat gag gtg tgg ctg cag        973
Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp Glu Val Trp Leu Gln           
    290                 295                 300                           

gtg aca gga gga gag agg ttc aat ggc ttg ttt gct gat gag gac gat       1021
Val Thr Gly Gly Glu Arg Phe Asn Gly Leu Phe Ala Asp Glu Asp Asp           
305                 310                 315                 320           

gac aca act ttc aca ggg ttc ctt ctg ttc agc agc ccg tga               1063
Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser Ser Pro                       
                325                 330                                   

cagaggagag tttaaaaatc cgccacacca tccatcagaa tcagcttggg atgaacttat     1123

tcagatggtt ttactttatt aattcctcca attattacaa taatcataaa aaggtgaaaa     1183

tggaaaagtt attcccaaaa ctgattctgt gtaacttact atttttccag gagtaaatat     1243

ttaaaatagc tgcatggttt attctaattt atttcacatt tcttattcct attatctgaa     1303

gaatccctcg tctgtgcgtt tcttgtggga agagtgtttt aatatcattt tagtgctctg     1363

aggagtcata tgaagatgta tccctcatct gtgtttctga ggacattaag gggaaattag     1423

agggaaatgt ttattcaatt tagtactagc aacagcttta agctggtgat gctgtcatac     1483

tccagaaagc tgtagacact gctcattttg tcttttaaaa aaattttatt ttattttaag     1543

ttctgggata catatgcaaa acatgcatgt ttgttacata ggtaaacatg tgctgtggtg     1603

gtttgctgta tctatcaacc catcacctag gtattaagcc ctgcatgcat tagctatttg     1663

tcctggtgct ctccctccca ctttgctcat tttctaacct aggttttaat caccatttta     1723

cccaacaaat cattgttcga tcattatttg ccagacttga atctctatgt gttttctagg     1783

actgctctaa taaagtacac aaactgggag tctttaaaca acaaaaaaaa aaaaaaaaaa     1843

aaaaaa                                                                1849


<210>  366
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  366

Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu Ile Cys Thr Gly Asn 
1               5                   10                  15      


Ile Asn Ser Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly 
            20                  25                  30          


Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala 
        35                  40                  45              


Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro 
    50                  55                  60                  


Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser 
                85                  90                  95      


Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys 
            100                 105                 110         


Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly 
        115                 120                 125             


Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro 
    130                 135                 140                 


Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro 
145                 150                 155                 160 


Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly 
                165                 170                 175     


Val Arg Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu Lys Gly Lys 
            180                 185                 190         


Ile Gly Glu Thr Leu Val Leu Pro Lys Ser Ala Phe Thr Val Gly Leu 
        195                 200                 205             


Thr Val Leu Ser Lys Phe Pro Ser Ser Asp Met Pro Ile Lys Phe Asp 
    210                 215                 220                 


Lys Ile Leu Tyr Asn Glu Phe Asn His Tyr Asp Thr Ala Ala Gly Lys 
225                 230                 235                 240 


Phe Thr Cys His Ile Ala Gly Val Tyr Tyr Phe Thr Tyr His Ile Thr 
                245                 250                 255     


Val Phe Ser Arg Asn Val Gln Val Ser Leu Val Lys Asn Gly Val Lys 
            260                 265                 270         


Ile Leu His Thr Lys Asp Ala Tyr Met Ser Ser Glu Asp Gln Ala Ser 
        275                 280                 285             


Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp Glu Val Trp Leu Gln 
    290                 295                 300                 


Val Thr Gly Gly Glu Arg Phe Asn Gly Leu Phe Ala Asp Glu Asp Asp 
305                 310                 315                 320 


Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser Ser Pro 
                325                 330             


<210>  367
<211>  5503
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (899)..(3697)

<400>  367
ttcatctgta cctttcaagt attcaaatag aaaaatataa acaatgtaaa taaaatagca       60

aaacaatgta atatctcata aaactgcaat ggtaaaagca tttatcctat tgaaattcca      120

caatttttat ttgaaaatat tatcgacatg taattcaagt ggcatttaga agaataattt      180

aaaagcaaca actctataga aagcttgtaa aatgattaag tagtttaaac caaataaaac      240

aatttctgag tcagtcatct ccagtaggtc tattttagtc tcaagataaa ttcatttctg      300

gtgacaactg aagttcttag ttatttgtta gtatatattg gagacattta caataaagct      360

tagagcacaa tgggaaatga aagtatcatg ttttttttaa gaccaaatgt attgcagaaa      420

tgtgagtaat ttaatccgat gctacaatct gatcattctg atctaatctg atcatttaat      480

aacactaaat aaaaccttca tctcacattc tttggctgtt tcttttaaaa tatgggttta      540

cggataaatc aaataaattc aaaacaaagt aataagcaaa tgattttttt ttctcagtaa      600

tctagtagag tattacattt agaagtaatc tgtatctcag tgcagtaact atttaggact      660

gtaagcgccg ctgttcacct actggaagac aaatgcaacc gaaaacactc agatctcaca      720

cctcacgaag acccgcagat gccacaaact aactgctgga ctgcagcgaa acccgacccc      780

tgtttggagg cactccaggt ttccggagga ttgtcatctc catagctgcg gcaagaaact      840

aaataagacc catttatgca cagtgaagat tctgagagga ttctgcagca aaacaaca        898

atg gcc gct cca cag agt cgc ccc aga cgc ggc gag ctg atc ctg ctg        946
Met Ala Ala Pro Gln Ser Arg Pro Arg Arg Gly Glu Leu Ile Leu Leu           
1               5                   10                  15                

tgc gcg ctg ctg gga acg ctg tgg gaa atc ggg agg gga cag att cgc        994
Cys Ala Leu Leu Gly Thr Leu Trp Glu Ile Gly Arg Gly Gln Ile Arg           
            20                  25                  30                    

tac tct gtg cca gaa gag acg gac aaa ggc tcc ttc gtg ggt aat atc       1042
Tyr Ser Val Pro Glu Glu Thr Asp Lys Gly Ser Phe Val Gly Asn Ile           
        35                  40                  45                        

tcc aag gac ctg ggg ctg gac ccc cgg aag ctg gcg aag cac gga gtc       1090
Ser Lys Asp Leu Gly Leu Asp Pro Arg Lys Leu Ala Lys His Gly Val           
    50                  55                  60                            

cgt atc gtc tcc aga ggt agg acg cag ctc ttt gct ctg aac ccg cgc       1138
Arg Ile Val Ser Arg Gly Arg Thr Gln Leu Phe Ala Leu Asn Pro Arg           
65                  70                  75                  80            

agc ggc agc ttg atc acc gcg ggc agg ata gat cgg gag gag ctc tgc       1186
Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu Cys           
                85                  90                  95                

gct cag agc ccg cgg tgt ctg ata aat att aac acc ctg gtt gag gat       1234
Ala Gln Ser Pro Arg Cys Leu Ile Asn Ile Asn Thr Leu Val Glu Asp           
            100                 105                 110                   

aaa gga aaa ctc ttt ggg gta gaa ata gaa ata att gat att aac gat       1282
Lys Gly Lys Leu Phe Gly Val Glu Ile Glu Ile Ile Asp Ile Asn Asp           
        115                 120                 125                       

aat aac cca aaa ttc cag gtc gaa gat cta gaa gta aaa att aac gaa       1330
Asn Asn Pro Lys Phe Gln Val Glu Asp Leu Glu Val Lys Ile Asn Glu           
    130                 135                 140                           

atc gcg gtt cct gga gca cgt tat cca ctc cca gaa gct gtt gac ccg       1378
Ile Ala Val Pro Gly Ala Arg Tyr Pro Leu Pro Glu Ala Val Asp Pro           
145                 150                 155                 160           

gat gtg ggc gtg aac tcc ctc cag agc tac cag ctc agc ccc aat cac       1426
Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn His           
                165                 170                 175               

cac ttc tcc ctg gac gtg cag act gga gac aat gga gcc ata aac cca       1474
His Phe Ser Leu Asp Val Gln Thr Gly Asp Asn Gly Ala Ile Asn Pro           
            180                 185                 190                   

gag ctg gtg ctg gag cgc gcc ctg gac agg gag gaa gag gct gct cac       1522
Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Glu Glu Ala Ala His           
        195                 200                 205                       

cac ctg gtc ctc acg gcc tcg gat ggc ggc aag ccg cct cgc tct agc       1570
His Leu Val Leu Thr Ala Ser Asp Gly Gly Lys Pro Pro Arg Ser Ser           
    210                 215                 220                           

aca gtg cgc atc cac gtg aca gtg ttg gat aca aat gac aat gcc ccg       1618
Thr Val Arg Ile His Val Thr Val Leu Asp Thr Asn Asp Asn Ala Pro           
225                 230                 235                 240           

gtt ttt cct cac ccg att tac cga gtg aaa gtc ctt gag aac atg ccc       1666
Val Phe Pro His Pro Ile Tyr Arg Val Lys Val Leu Glu Asn Met Pro           
                245                 250                 255               

cca ggc acg cgg ctg ctt act gta aca gcc agc gac ccg gat gag gga       1714
Pro Gly Thr Arg Leu Leu Thr Val Thr Ala Ser Asp Pro Asp Glu Gly           
            260                 265                 270                   

atc aac gga aaa gtg gca tac aaa ttc cgg aaa att aat gaa aaa caa       1762
Ile Asn Gly Lys Val Ala Tyr Lys Phe Arg Lys Ile Asn Glu Lys Gln           
        275                 280                 285                       

act ccg tta ttc cag ctt aat gaa aat act ggg gaa ata tca ata gca       1810
Thr Pro Leu Phe Gln Leu Asn Glu Asn Thr Gly Glu Ile Ser Ile Ala           
    290                 295                 300                           

aaa agt cta gat tat gaa gaa tgt tca ttt tat gaa atg gaa ata caa       1858
Lys Ser Leu Asp Tyr Glu Glu Cys Ser Phe Tyr Glu Met Glu Ile Gln           
305                 310                 315                 320           

gcc gaa gat gtg ggg gca ctt ctg ggg agg acc aaa ttg ctc att tcg       1906
Ala Glu Asp Val Gly Ala Leu Leu Gly Arg Thr Lys Leu Leu Ile Ser           
                325                 330                 335               

gtg gaa gat gta aat gac aat aga cca gaa gtg atc att acg tct ttg       1954
Val Glu Asp Val Asn Asp Asn Arg Pro Glu Val Ile Ile Thr Ser Leu           
            340                 345                 350                   

ttt agc cca gtg tta gaa aat tct ctt ccc ggg aca gta att gcc ttc       2002
Phe Ser Pro Val Leu Glu Asn Ser Leu Pro Gly Thr Val Ile Ala Phe           
        355                 360                 365                       

ttg agt gtg cat gac caa gac tct gga aag aat ggt caa gtt gtc tgt       2050
Leu Ser Val His Asp Gln Asp Ser Gly Lys Asn Gly Gln Val Val Cys           
    370                 375                 380                           

tac aca cgt gat aat tta cct ttt aaa tta gaa aag tca ata ggt aat       2098
Tyr Thr Arg Asp Asn Leu Pro Phe Lys Leu Glu Lys Ser Ile Gly Asn           
385                 390                 395                 400           

tat tat aga tta gtg aca agg aaa tat ttg gac cga gaa aat gtc tct       2146
Tyr Tyr Arg Leu Val Thr Arg Lys Tyr Leu Asp Arg Glu Asn Val Ser           
                405                 410                 415               

atc tac aat atc aca gtg atg gcc tca gat cta gga aca cca cct ctg       2194
Ile Tyr Asn Ile Thr Val Met Ala Ser Asp Leu Gly Thr Pro Pro Leu           
            420                 425                 430                   

tcc act gaa act caa atc gct ctg cac gtg gca gac att aac gac aac       2242
Ser Thr Glu Thr Gln Ile Ala Leu His Val Ala Asp Ile Asn Asp Asn           
        435                 440                 445                       

cct cct act ttc cct cat gcc tcc tac tca gcg tat atc cta gag aac       2290
Pro Pro Thr Phe Pro His Ala Ser Tyr Ser Ala Tyr Ile Leu Glu Asn           
    450                 455                 460                           

aac ctg aga gga gcc tcc atc ttt tcc ttg act gca cac gac ccc gac       2338
Asn Leu Arg Gly Ala Ser Ile Phe Ser Leu Thr Ala His Asp Pro Asp           
465                 470                 475                 480           

agc cag gag aat gcc cag gtc act tac tct gtg acc gag gac acg ctg       2386
Ser Gln Glu Asn Ala Gln Val Thr Tyr Ser Val Thr Glu Asp Thr Leu           
                485                 490                 495               

cag ggg gcg ccc ctg tcc tcg tat atc tcc atc aac tct gac acc ggt       2434
Gln Gly Ala Pro Leu Ser Ser Tyr Ile Ser Ile Asn Ser Asp Thr Gly           
            500                 505                 510                   

gtc ctg tat gcg ctg caa tct ttc gac tat gag cag atc cga gac ctg       2482
Val Leu Tyr Ala Leu Gln Ser Phe Asp Tyr Glu Gln Ile Arg Asp Leu           
        515                 520                 525                       

cag cta ctg gta aca gcc agc gac agc ggg gac ccg ccc ctc agc agc       2530
Gln Leu Leu Val Thr Ala Ser Asp Ser Gly Asp Pro Pro Leu Ser Ser           
    530                 535                 540                           

aac atg tca ctg agc ctg ttc gtg ctg gac cag aat gac aac gcg ccc       2578
Asn Met Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala Pro           
545                 550                 555                 560           

gag atc ctg tac ccc gcc ctc ccc aca gac ggt tcc act ggc gtg gag       2626
Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu           
                565                 570                 575               

ctg gcg ccc cgc tcc gca gag cgt ggc tac ctg gtg acc aag gtg gtg       2674
Leu Ala Pro Arg Ser Ala Glu Arg Gly Tyr Leu Val Thr Lys Val Val           
            580                 585                 590                   

gcg gtg gac aga gac tcg ggc cag aac gcc tgg ctg tcc tac cgc ctg       2722
Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu           
        595                 600                 605                       

ctc aag gcc agc gag ccg gga ctc ttc tcg gtg ggt ctg cac acg ggc       2770
Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly           
    610                 615                 620                           

gag gtg cgc acg gcg cga gcc ctg ctg gac aga gat gcg ctc aag cag       2818
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln           
625                 630                 635                 640           

agc ctc gtg gtg gcc gtc cag gac cat ggc cag ccc cct ctc tcc gcc       2866
Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala           
                645                 650                 655               

act gtc acg ctc acc gta gcc gtg gct gac agc atc ccc gaa gtc ctg       2914
Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile Pro Glu Val Leu           
            660                 665                 670                   

acc gag ttg ggc agt ctg aag cct tcg gtc gac ccg aac gat tcg agc       2962
Thr Glu Leu Gly Ser Leu Lys Pro Ser Val Asp Pro Asn Asp Ser Ser           
        675                 680                 685                       

ctt aca ctc tat ctc gtg gtg gca gtg gct gcc atc tcc tgt gtc ttc       3010
Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Ile Ser Cys Val Phe           
    690                 695                 700                           

ctc gcc ttt gtc gct gtg ctt ctg ggg ctc agg ctg agg cgc tgg cac       3058
Leu Ala Phe Val Ala Val Leu Leu Gly Leu Arg Leu Arg Arg Trp His           
705                 710                 715                 720           

aag tca cgc ctg ctc cag gat tcc ggt ggc aga ttg gta ggc gtg cct       3106
Lys Ser Arg Leu Leu Gln Asp Ser Gly Gly Arg Leu Val Gly Val Pro           
                725                 730                 735               

gcc tca cat ttt gtg ggt gtt gag gag gta cag gct ttc ctg cag acc       3154
Ala Ser His Phe Val Gly Val Glu Glu Val Gln Ala Phe Leu Gln Thr           
            740                 745                 750                   

tat tcc cag gaa gtc tcc ctc acc gcc gac tcg cgg aag agt cac ctg       3202
Tyr Ser Gln Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu           
        755                 760                 765                       

atc ttt ccc cag ccc aac tac gca gac atg ctc atc agt cag gag ggc       3250
Ile Phe Pro Gln Pro Asn Tyr Ala Asp Met Leu Ile Ser Gln Glu Gly           
    770                 775                 780                           

tgt gag aaa aat gat tct ttg tta aca tcc gta gat ttt cat gaa tat       3298
Cys Glu Lys Asn Asp Ser Leu Leu Thr Ser Val Asp Phe His Glu Tyr           
785                 790                 795                 800           

aag aat gaa gct gat cat ggt cag caa gcc ccg ccc aac acg gac tgg       3346
Lys Asn Glu Ala Asp His Gly Gln Gln Ala Pro Pro Asn Thr Asp Trp           
                805                 810                 815               

cgt ttc tct cag gcc cag aga ccc ggc acc agc ggc tcc caa aat ggc       3394
Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly           
            820                 825                 830                   

gat gac acc ggc acc tgg ccc aac aac cag ttt gac aca gag atg ctg       3442
Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu           
        835                 840                 845                       

caa gcc atg atc ttg gcg tcc gcc agt gaa gct gct gat ggg agc tcc       3490
Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser           
    850                 855                 860                           

acc ctg gga ggg ggt gcc ggc acc atg gga ttg agc gcc cgc tac gga       3538
Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly           
865                 870                 875                 880           

ccc cag ttc acc ctg cag cac gtg ccc gac tac cgc cag aat gtc tac       3586
Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr           
                885                 890                 895               

atc cca ggc agc aat gcc aca ctg acc aac gca gct ggc aag cgg gat       3634
Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp           
            900                 905                 910                   

ggc aag gcc cca gca ggt ggc aat ggc aac aag aag aag tcg ggc aag       3682
Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys           
        915                 920                 925                       

aag gag aag aag taa catggaggcc aggccaagag ccacagggcg gcctctcccc       3737
Lys Glu Lys Lys                                                           
    930                                                                   

aaccagccca gcttctcctt acctgcaccc aggcctcaga gtttcagggc taacccccag     3797

aatactggta ggggccaagg ccatgctccc cttgggaaac agaaacaagt gcccagtcag     3857

cacctacccc ttccccccca gggggttgaa tatgcaaaag cagttccgct gggaaccccc     3917

atccaatcaa ctgctgtacc catgggggta gtggggttac tgtagacacc aagaaccatt     3977

tgccacaccc cgtttagtta cagctgaact cctccatctt ccaaatcaat caggcccatc     4037

catcccatgc ctccctcctc cccaccccac tccaacagtt cctctttccc gagtaaggtg     4097

gttggggtgt tgaagtacca agtaacctac aagcctccta gttctgaaaa gttggaaggg     4157

catcatgacc tcttggcctc tcctttgatt ctcaatcttc ccccaaagca tggtttggtg     4217

ccagcccctt cacctccttc cagagcccaa gatcaatgct caagttttgg aggacatgat     4277

caccatcccc atggtactga tgcttgctgg atttagggag ggcattttgc taccaagcct     4337

cttcccaacg ccctggggac cagtcttctg ttttgttttt cattgtttga cgtttccact     4397

gcatgccttg acttccccca cctcctcctc aaacaagaga ctccactgca tgttccaaga     4457

cagtatgggg tggtaagata aggaagggaa gtgtgtggat gtggatggtg ggggcatgga     4517

caaagcttga cacatcaagt tatcaaggcc ttggaggagg ctctgtatgt cctcagggga     4577

ctgacaacat cctccagatt ccagccataa accaataact aggctggacc cttcccacta     4637

cataataggg ctcagcccag gcagccagct ttgggctgag ctaacaggac caatggatta     4697

aactggcatt tcagtccaag gaagctcgaa gcaggtttag gaccaggtcc ccttgagagg     4757

tcagaggggc ctctgtgggt gctgggtact ccagaggtgc cactggtgga agggtcagcg     4817

gagccccagc aggaagggtg ggccagccag gccattctta gtccctgggt tggggaggca     4877

gggagctagg gcagggacca aatgaacaga aagtctcagc ccaggatggg gcttcttcaa     4937

cagggcccct gccctcctga agcctcagtc cttcaccttg ccaggtgccg tttctcttcc     4997

gtgaaggcca ctgcccaggt ccccagtgcg ccccctagtg gccatagcct ggttaaagtt     5057

ccccagtgcc tccttgtgca tagaccttct tctcccaccc ccttctgccc ctgggtcccc     5117

ggccatccag cggggctgcc agagaacccc agacctgccc ttacagtagt gtagcgcccc     5177

ctccctcttt cggctggtgt agaatagcca gtagtgtagt gcggtgtgct tttacgtgat     5237

ggcgggtggg cagcgggcgg cgggctccgc gcagccgtct gtccttgatc tgcccgcggc     5297

ggcccgtgtt gtgttttgtg ctgtgtccac gcgctaaggc gaccccctcc cccgtactga     5357

cttctcctat aagcgcttct cttcgcatag tcacgtagct cccaccccac cctcttcctg     5417

tgtctcacgc aagttttata ctctaatatt tatatggctt tttttcttcg acaaaaaaat     5477

aataaaacgt ttcttctgaa aagctg                                          5503


<210>  368
<211>  932
<212>  PRT
<213>  Homo sapiens

<400>  368

Met Ala Ala Pro Gln Ser Arg Pro Arg Arg Gly Glu Leu Ile Leu Leu 
1               5                   10                  15      


Cys Ala Leu Leu Gly Thr Leu Trp Glu Ile Gly Arg Gly Gln Ile Arg 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Thr Asp Lys Gly Ser Phe Val Gly Asn Ile 
        35                  40                  45              


Ser Lys Asp Leu Gly Leu Asp Pro Arg Lys Leu Ala Lys His Gly Val 
    50                  55                  60                  


Arg Ile Val Ser Arg Gly Arg Thr Gln Leu Phe Ala Leu Asn Pro Arg 
65                  70                  75                  80  


Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Ala Gln Ser Pro Arg Cys Leu Ile Asn Ile Asn Thr Leu Val Glu Asp 
            100                 105                 110         


Lys Gly Lys Leu Phe Gly Val Glu Ile Glu Ile Ile Asp Ile Asn Asp 
        115                 120                 125             


Asn Asn Pro Lys Phe Gln Val Glu Asp Leu Glu Val Lys Ile Asn Glu 
    130                 135                 140                 


Ile Ala Val Pro Gly Ala Arg Tyr Pro Leu Pro Glu Ala Val Asp Pro 
145                 150                 155                 160 


Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn His 
                165                 170                 175     


His Phe Ser Leu Asp Val Gln Thr Gly Asp Asn Gly Ala Ile Asn Pro 
            180                 185                 190         


Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Glu Glu Ala Ala His 
        195                 200                 205             


His Leu Val Leu Thr Ala Ser Asp Gly Gly Lys Pro Pro Arg Ser Ser 
    210                 215                 220                 


Thr Val Arg Ile His Val Thr Val Leu Asp Thr Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Val Phe Pro His Pro Ile Tyr Arg Val Lys Val Leu Glu Asn Met Pro 
                245                 250                 255     


Pro Gly Thr Arg Leu Leu Thr Val Thr Ala Ser Asp Pro Asp Glu Gly 
            260                 265                 270         


Ile Asn Gly Lys Val Ala Tyr Lys Phe Arg Lys Ile Asn Glu Lys Gln 
        275                 280                 285             


Thr Pro Leu Phe Gln Leu Asn Glu Asn Thr Gly Glu Ile Ser Ile Ala 
    290                 295                 300                 


Lys Ser Leu Asp Tyr Glu Glu Cys Ser Phe Tyr Glu Met Glu Ile Gln 
305                 310                 315                 320 


Ala Glu Asp Val Gly Ala Leu Leu Gly Arg Thr Lys Leu Leu Ile Ser 
                325                 330                 335     


Val Glu Asp Val Asn Asp Asn Arg Pro Glu Val Ile Ile Thr Ser Leu 
            340                 345                 350         


Phe Ser Pro Val Leu Glu Asn Ser Leu Pro Gly Thr Val Ile Ala Phe 
        355                 360                 365             


Leu Ser Val His Asp Gln Asp Ser Gly Lys Asn Gly Gln Val Val Cys 
    370                 375                 380                 


Tyr Thr Arg Asp Asn Leu Pro Phe Lys Leu Glu Lys Ser Ile Gly Asn 
385                 390                 395                 400 


Tyr Tyr Arg Leu Val Thr Arg Lys Tyr Leu Asp Arg Glu Asn Val Ser 
                405                 410                 415     


Ile Tyr Asn Ile Thr Val Met Ala Ser Asp Leu Gly Thr Pro Pro Leu 
            420                 425                 430         


Ser Thr Glu Thr Gln Ile Ala Leu His Val Ala Asp Ile Asn Asp Asn 
        435                 440                 445             


Pro Pro Thr Phe Pro His Ala Ser Tyr Ser Ala Tyr Ile Leu Glu Asn 
    450                 455                 460                 


Asn Leu Arg Gly Ala Ser Ile Phe Ser Leu Thr Ala His Asp Pro Asp 
465                 470                 475                 480 


Ser Gln Glu Asn Ala Gln Val Thr Tyr Ser Val Thr Glu Asp Thr Leu 
                485                 490                 495     


Gln Gly Ala Pro Leu Ser Ser Tyr Ile Ser Ile Asn Ser Asp Thr Gly 
            500                 505                 510         


Val Leu Tyr Ala Leu Gln Ser Phe Asp Tyr Glu Gln Ile Arg Asp Leu 
        515                 520                 525             


Gln Leu Leu Val Thr Ala Ser Asp Ser Gly Asp Pro Pro Leu Ser Ser 
    530                 535                 540                 


Asn Met Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala Pro 
545                 550                 555                 560 


Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu 
                565                 570                 575     


Leu Ala Pro Arg Ser Ala Glu Arg Gly Tyr Leu Val Thr Lys Val Val 
            580                 585                 590         


Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu 
        595                 600                 605             


Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly 
    610                 615                 620                 


Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln 
625                 630                 635                 640 


Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala 
                645                 650                 655     


Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile Pro Glu Val Leu 
            660                 665                 670         


Thr Glu Leu Gly Ser Leu Lys Pro Ser Val Asp Pro Asn Asp Ser Ser 
        675                 680                 685             


Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Ile Ser Cys Val Phe 
    690                 695                 700                 


Leu Ala Phe Val Ala Val Leu Leu Gly Leu Arg Leu Arg Arg Trp His 
705                 710                 715                 720 


Lys Ser Arg Leu Leu Gln Asp Ser Gly Gly Arg Leu Val Gly Val Pro 
                725                 730                 735     


Ala Ser His Phe Val Gly Val Glu Glu Val Gln Ala Phe Leu Gln Thr 
            740                 745                 750         


Tyr Ser Gln Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu 
        755                 760                 765             


Ile Phe Pro Gln Pro Asn Tyr Ala Asp Met Leu Ile Ser Gln Glu Gly 
    770                 775                 780                 


Cys Glu Lys Asn Asp Ser Leu Leu Thr Ser Val Asp Phe His Glu Tyr 
785                 790                 795                 800 


Lys Asn Glu Ala Asp His Gly Gln Gln Ala Pro Pro Asn Thr Asp Trp 
                805                 810                 815     


Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly 
            820                 825                 830         


Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu 
        835                 840                 845             


Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser 
    850                 855                 860                 


Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly 
865                 870                 875                 880 


Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr 
                885                 890                 895     


Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp 
            900                 905                 910         


Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys 
        915                 920                 925             


Lys Glu Lys Lys 
    930         


<210>  369
<211>  2245
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (280)..(1995)

<400>  369
gggacgcggg cggcggcgga ggctgcggga gtcgctgccg ctcgagggac cgcggacccg       60

ggaggtccgg ctcccggcgc cgggcctcag tttcccccac gggagccgca tcccaccccc      120

agagccccag cgcgtccgcg gggtccgagt cgcggccggc gcggggcggg gaggggcggg      180

aagtttgcgc cctacacgcg gcctcgcaga cttggcggct ccgctcccgg ccgggagcag      240

gtggccatgg tgcccggccc tgcctcatag caggctgcc atg tcg cgg gag gcg         294
                                           Met Ser Arg Glu Ala            
                                           1               5              

ggc tca tgc cgc gtg ggc aca ggg gcg agg gcg cgg tct cgg aag ccc        342
Gly Ser Cys Arg Val Gly Thr Gly Ala Arg Ala Arg Ser Arg Lys Pro           
                10                  15                  20                

aag aag cca cac tac atc ccg cgg ccc tgg ggc aaa ccc tac aac tac        390
Lys Lys Pro His Tyr Ile Pro Arg Pro Trp Gly Lys Pro Tyr Asn Tyr           
            25                  30                  35                    

aaa tgc ttc cag tgc ccc ttc acc tgc ctg gag aag tca cac ctc tac        438
Lys Cys Phe Gln Cys Pro Phe Thr Cys Leu Glu Lys Ser His Leu Tyr           
        40                  45                  50                        

aac cac atg aag tac agc ctc tgc aag gac tcc ctg tcc ctg ctg cta        486
Asn His Met Lys Tyr Ser Leu Cys Lys Asp Ser Leu Ser Leu Leu Leu           
    55                  60                  65                            

gac tcc cca gac tgg gcg tgc cgc cgt ggc tcc acc acg cct agg ccc        534
Asp Ser Pro Asp Trp Ala Cys Arg Arg Gly Ser Thr Thr Pro Arg Pro           
70                  75                  80                  85            

cac gca ccc acc cca gac cgc cct ggg gag tcc gac ccc ggc agg caa        582
His Ala Pro Thr Pro Asp Arg Pro Gly Glu Ser Asp Pro Gly Arg Gln           
                90                  95                  100               

ccc cag gga gca cgg ccc aca ggt gct gcc ccc gcg cct gac ctc gtg        630
Pro Gln Gly Ala Arg Pro Thr Gly Ala Ala Pro Ala Pro Asp Leu Val           
            105                 110                 115                   

gtc gcc gac atc cac tcc ctg cac tgt ggc gga ggc ccc aag tcc agg        678
Val Ala Asp Ile His Ser Leu His Cys Gly Gly Gly Pro Lys Ser Arg           
        120                 125                 130                       

gcc aag ggg tcc cca ggg cca cca ccc cct gtg gct agg gcc acc cgg        726
Ala Lys Gly Ser Pro Gly Pro Pro Pro Pro Val Ala Arg Ala Thr Arg           
    135                 140                 145                           

aag ggt ccc ggc ccc agt ggg ctc ctg cct gag tcg tgg aag ccg ggg        774
Lys Gly Pro Gly Pro Ser Gly Leu Leu Pro Glu Ser Trp Lys Pro Gly           
150                 155                 160                 165           

atg gga ggg gac cca agg ggc gtg ggt gcg ggg gac atg gcc tca gca        822
Met Gly Gly Asp Pro Arg Gly Val Gly Ala Gly Asp Met Ala Ser Ala           
                170                 175                 180               

ggc cct gag ggc agc gtc ccc tgc tat ccc ccg cct gcc cca ggg gag        870
Gly Pro Glu Gly Ser Val Pro Cys Tyr Pro Pro Pro Ala Pro Gly Glu           
            185                 190                 195                   

ttc cct gag gcc cac agc ctc cac ctg tct ctg ctg ggc gtc aac tac        918
Phe Pro Glu Ala His Ser Leu His Leu Ser Leu Leu Gly Val Asn Tyr           
        200                 205                 210                       

ccg ctc agc ccc ggc ctc ttc tcc tac ttg ggg ccc tca ctg gcc gct        966
Pro Leu Ser Pro Gly Leu Phe Ser Tyr Leu Gly Pro Ser Leu Ala Ala           
    215                 220                 225                           

gca gcc cat gtg ccc ttc ctg gcc tcg gcc agc ccc ctg ctg ccc ccg       1014
Ala Ala His Val Pro Phe Leu Ala Ser Ala Ser Pro Leu Leu Pro Pro           
230                 235                 240                 245           

gcc acg gcc ttc cca gcc gtg cag ccc cct cag cgc ccc acc ccg gcc       1062
Ala Thr Ala Phe Pro Ala Val Gln Pro Pro Gln Arg Pro Thr Pro Ala           
                250                 255                 260               

ccc cgc ctg tac tac ccg ctg ctt ctg gag cac act ctg ggg ctg cca       1110
Pro Arg Leu Tyr Tyr Pro Leu Leu Leu Glu His Thr Leu Gly Leu Pro           
            265                 270                 275                   

gca ggc aaa gct gcc ctt gcc aag gcc cct gtc tcc ccc agg agc ccc       1158
Ala Gly Lys Ala Ala Leu Ala Lys Ala Pro Val Ser Pro Arg Ser Pro           
        280                 285                 290                       

tct ggg act ccg gct cct ggc ctg ctg aag gtg cca gtt cca ggg ctg       1206
Ser Gly Thr Pro Ala Pro Gly Leu Leu Lys Val Pro Val Pro Gly Leu           
    295                 300                 305                           

ggg ccc tgg ccc cga gtc acc ccc agg gac cca ggg cag gag ggg gag       1254
Gly Pro Trp Pro Arg Val Thr Pro Arg Asp Pro Gly Gln Glu Gly Glu           
310                 315                 320                 325           

ctg gag cgg gca gcc cag agt gac ccc agg agg agg ctg tcc ctg gga       1302
Leu Glu Arg Ala Ala Gln Ser Asp Pro Arg Arg Arg Leu Ser Leu Gly           
                330                 335                 340               

agc agg ctg gag ctt ccg aag gca tcc ccc agc ctg aca agg ttc tgt       1350
Ser Arg Leu Glu Leu Pro Lys Ala Ser Pro Ser Leu Thr Arg Phe Cys           
            345                 350                 355                   

tcc cgg agc agc ctg ccc acc ggc tcc tct gtg atg ctg tgg cct gag       1398
Ser Arg Ser Ser Leu Pro Thr Gly Ser Ser Val Met Leu Trp Pro Glu           
        360                 365                 370                       

gac ggg gat cca ggc ggc cct gag acc ccc ggc cct gag ggc ccc ctc       1446
Asp Gly Asp Pro Gly Gly Pro Glu Thr Pro Gly Pro Glu Gly Pro Leu           
    375                 380                 385                           

ccc ctg cag cca cgg ggc cca gtg cca gga agc ccg gag cat gtg ggc       1494
Pro Leu Gln Pro Arg Gly Pro Val Pro Gly Ser Pro Glu His Val Gly           
390                 395                 400                 405           

gag gac ctg acc cga gcc ctc ggt gac tac gcc agg gtg gag cag cgc       1542
Glu Asp Leu Thr Arg Ala Leu Gly Asp Tyr Ala Arg Val Glu Gln Arg           
                410                 415                 420               

ctg gga cag ttg ggg ccc gcg ggg ggc ctg gcc ccg aga ccc ctg cgg       1590
Leu Gly Gln Leu Gly Pro Ala Gly Gly Leu Ala Pro Arg Pro Leu Arg           
            425                 430                 435                   

gag cag ctg ggc aag atc cgc ctg gag ctg ctc acc att cac cag gcg       1638
Glu Gln Leu Gly Lys Ile Arg Leu Glu Leu Leu Thr Ile His Gln Ala           
        440                 445                 450                       

ctg gag cag gcc gtg agg ccg cca gac gca ccc ctc gac ctc tct gtg       1686
Leu Glu Gln Ala Val Arg Pro Pro Asp Ala Pro Leu Asp Leu Ser Val           
    455                 460                 465                           

aaa cgt gcg ccc gcc aag ggg ccc cag gct ctt gga gag gcg tgg ggg       1734
Lys Arg Ala Pro Ala Lys Gly Pro Gln Ala Leu Gly Glu Ala Trp Gly           
470                 475                 480                 485           

cgg ccc gag ctg ggt ccc gtg ttg acc ggg ggc acc ccc gag cca ccc       1782
Arg Pro Glu Leu Gly Pro Val Leu Thr Gly Gly Thr Pro Glu Pro Pro           
                490                 495                 500               

ggc atg ctg ggc cct gca gcg ccc caa ccc ttc tct ggc cac acc acc       1830
Gly Met Leu Gly Pro Ala Ala Pro Gln Pro Phe Ser Gly His Thr Thr           
            505                 510                 515                   

aag tgt gag gcc gac tcc agc gtc cca ccc cca ggg ctc ccc ctc gca       1878
Lys Cys Glu Ala Asp Ser Ser Val Pro Pro Pro Gly Leu Pro Leu Ala           
        520                 525                 530                       

gcc cca gat gac cct gtc att cct ggc agt ggc tgg ggc acc tgt gtt       1926
Ala Pro Asp Asp Pro Val Ile Pro Gly Ser Gly Trp Gly Thr Cys Val           
    535                 540                 545                           

gcg acg agg agt tcc cag acc cct gag gct gtc tgt ggc ctg cag agc       1974
Ala Thr Arg Ser Ser Gln Thr Pro Glu Ala Val Cys Gly Leu Gln Ser           
550                 555                 560                 565           

ccc cag ggc gcc gag gtc tga cctgcagcgc ctgaggtccg actgtctctg          2025
Pro Gln Gly Ala Glu Val                                                   
                570                                                       

cctgcagcat gccggcccct ctcctgcagc ccctgcccct cacctgcctg ggacctgccc     2085

cgcctccgca tgcatgtgga tagaccccca cgggccgtgg ccaacgcttg tccctggggc     2145

cacacaggga cactggaggt cacagttatt tattgatcac aattgtggac attaaaacag     2205

aaactgttca caaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           2245


<210>  370
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  370

Met Ser Arg Glu Ala Gly Ser Cys Arg Val Gly Thr Gly Ala Arg Ala 
1               5                   10                  15      


Arg Ser Arg Lys Pro Lys Lys Pro His Tyr Ile Pro Arg Pro Trp Gly 
            20                  25                  30          


Lys Pro Tyr Asn Tyr Lys Cys Phe Gln Cys Pro Phe Thr Cys Leu Glu 
        35                  40                  45              


Lys Ser His Leu Tyr Asn His Met Lys Tyr Ser Leu Cys Lys Asp Ser 
    50                  55                  60                  


Leu Ser Leu Leu Leu Asp Ser Pro Asp Trp Ala Cys Arg Arg Gly Ser 
65                  70                  75                  80  


Thr Thr Pro Arg Pro His Ala Pro Thr Pro Asp Arg Pro Gly Glu Ser 
                85                  90                  95      


Asp Pro Gly Arg Gln Pro Gln Gly Ala Arg Pro Thr Gly Ala Ala Pro 
            100                 105                 110         


Ala Pro Asp Leu Val Val Ala Asp Ile His Ser Leu His Cys Gly Gly 
        115                 120                 125             


Gly Pro Lys Ser Arg Ala Lys Gly Ser Pro Gly Pro Pro Pro Pro Val 
    130                 135                 140                 


Ala Arg Ala Thr Arg Lys Gly Pro Gly Pro Ser Gly Leu Leu Pro Glu 
145                 150                 155                 160 


Ser Trp Lys Pro Gly Met Gly Gly Asp Pro Arg Gly Val Gly Ala Gly 
                165                 170                 175     


Asp Met Ala Ser Ala Gly Pro Glu Gly Ser Val Pro Cys Tyr Pro Pro 
            180                 185                 190         


Pro Ala Pro Gly Glu Phe Pro Glu Ala His Ser Leu His Leu Ser Leu 
        195                 200                 205             


Leu Gly Val Asn Tyr Pro Leu Ser Pro Gly Leu Phe Ser Tyr Leu Gly 
    210                 215                 220                 


Pro Ser Leu Ala Ala Ala Ala His Val Pro Phe Leu Ala Ser Ala Ser 
225                 230                 235                 240 


Pro Leu Leu Pro Pro Ala Thr Ala Phe Pro Ala Val Gln Pro Pro Gln 
                245                 250                 255     


Arg Pro Thr Pro Ala Pro Arg Leu Tyr Tyr Pro Leu Leu Leu Glu His 
            260                 265                 270         


Thr Leu Gly Leu Pro Ala Gly Lys Ala Ala Leu Ala Lys Ala Pro Val 
        275                 280                 285             


Ser Pro Arg Ser Pro Ser Gly Thr Pro Ala Pro Gly Leu Leu Lys Val 
    290                 295                 300                 


Pro Val Pro Gly Leu Gly Pro Trp Pro Arg Val Thr Pro Arg Asp Pro 
305                 310                 315                 320 


Gly Gln Glu Gly Glu Leu Glu Arg Ala Ala Gln Ser Asp Pro Arg Arg 
                325                 330                 335     


Arg Leu Ser Leu Gly Ser Arg Leu Glu Leu Pro Lys Ala Ser Pro Ser 
            340                 345                 350         


Leu Thr Arg Phe Cys Ser Arg Ser Ser Leu Pro Thr Gly Ser Ser Val 
        355                 360                 365             


Met Leu Trp Pro Glu Asp Gly Asp Pro Gly Gly Pro Glu Thr Pro Gly 
    370                 375                 380                 


Pro Glu Gly Pro Leu Pro Leu Gln Pro Arg Gly Pro Val Pro Gly Ser 
385                 390                 395                 400 


Pro Glu His Val Gly Glu Asp Leu Thr Arg Ala Leu Gly Asp Tyr Ala 
                405                 410                 415     


Arg Val Glu Gln Arg Leu Gly Gln Leu Gly Pro Ala Gly Gly Leu Ala 
            420                 425                 430         


Pro Arg Pro Leu Arg Glu Gln Leu Gly Lys Ile Arg Leu Glu Leu Leu 
        435                 440                 445             


Thr Ile His Gln Ala Leu Glu Gln Ala Val Arg Pro Pro Asp Ala Pro 
    450                 455                 460                 


Leu Asp Leu Ser Val Lys Arg Ala Pro Ala Lys Gly Pro Gln Ala Leu 
465                 470                 475                 480 


Gly Glu Ala Trp Gly Arg Pro Glu Leu Gly Pro Val Leu Thr Gly Gly 
                485                 490                 495     


Thr Pro Glu Pro Pro Gly Met Leu Gly Pro Ala Ala Pro Gln Pro Phe 
            500                 505                 510         


Ser Gly His Thr Thr Lys Cys Glu Ala Asp Ser Ser Val Pro Pro Pro 
        515                 520                 525             


Gly Leu Pro Leu Ala Ala Pro Asp Asp Pro Val Ile Pro Gly Ser Gly 
    530                 535                 540                 


Trp Gly Thr Cys Val Ala Thr Arg Ser Ser Gln Thr Pro Glu Ala Val 
545                 550                 555                 560 


Cys Gly Leu Gln Ser Pro Gln Gly Ala Glu Val 
                565                 570     


<210>  371
<211>  2614
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (157)..(2298)

<400>  371
agcccccaag agctctgtgc gggattctag gctcccctgt gacagccgcg gcaggaagca       60

ggcgggcgct ccccggccac aggcctgttg ttctcggaag ggagaaagct ggacatttcc      120

ccacgtaact cccagctctg ggcctagagt gcgtgc atg gcg aag tcc ccg gag        174
                                        Met Ala Lys Ser Pro Glu           
                                        1               5                 

aac tct acc ctg gag gag att ctg ggg cag tat caa cgg agt ctc cgg        222
Asn Ser Thr Leu Glu Glu Ile Leu Gly Gln Tyr Gln Arg Ser Leu Arg           
            10                  15                  20                    

gaa cat gcc agc aga agc att cac caa ctg aca tgt gcc ctg aaa gaa        270
Glu His Ala Ser Arg Ser Ile His Gln Leu Thr Cys Ala Leu Lys Glu           
        25                  30                  35                        

ggc gat gtc act att gga gaa gat gca cca aat ctt tct ttt agc acc        318
Gly Asp Val Thr Ile Gly Glu Asp Ala Pro Asn Leu Ser Phe Ser Thr           
    40                  45                  50                            

agt gtg gga aat gag gac gcc agg aca gcc tgg ccc gaa tta caa cag        366
Ser Val Gly Asn Glu Asp Ala Arg Thr Ala Trp Pro Glu Leu Gln Gln           
55                  60                  65                  70            

agc cat gct gtt aat cag ctc aaa gat ttg ttg cgc caa caa gca gat        414
Ser His Ala Val Asn Gln Leu Lys Asp Leu Leu Arg Gln Gln Ala Asp           
                75                  80                  85                

aag gaa agt gaa gta tct ccg tca aga aga aga aaa atg tcc ccc ttg        462
Lys Glu Ser Glu Val Ser Pro Ser Arg Arg Arg Lys Met Ser Pro Leu           
            90                  95                  100                   

agg tca tta gaa cat gag gaa acc aat atg cct act atg cac gac ctt        510
Arg Ser Leu Glu His Glu Glu Thr Asn Met Pro Thr Met His Asp Leu           
        105                 110                 115                       

gtt cat act att aat gac cag tct caa tat att cat cat tta gag gca        558
Val His Thr Ile Asn Asp Gln Ser Gln Tyr Ile His His Leu Glu Ala           
    120                 125                 130                           

gaa gtt aag ttc tgc aag gag gaa ctc tct gga atg aaa aat aaa ata        606
Glu Val Lys Phe Cys Lys Glu Glu Leu Ser Gly Met Lys Asn Lys Ile           
135                 140                 145                 150           

caa gta gtt gtg ctt gaa aac gaa ggg ctc cag caa cag cta aaa tct        654
Gln Val Val Val Leu Glu Asn Glu Gly Leu Gln Gln Gln Leu Lys Ser           
                155                 160                 165               

caa aga caa gag gag aca ctg agg gaa caa aca ctt ctg gat gca tcc        702
Gln Arg Gln Glu Glu Thr Leu Arg Glu Gln Thr Leu Leu Asp Ala Ser           
            170                 175                 180                   

gga aac atg cac aat tct tgg att aca aca ggt gaa gat tct ggg gtg        750
Gly Asn Met His Asn Ser Trp Ile Thr Thr Gly Glu Asp Ser Gly Val           
        185                 190                 195                       

ggc gaa acc tcc aaa aga cca ttt tcc cat gac aat gca gat ttt ggc        798
Gly Glu Thr Ser Lys Arg Pro Phe Ser His Asp Asn Ala Asp Phe Gly           
    200                 205                 210                           

aaa gct gca tct gct ggt gag cag cta gaa ctg gag aag cta aaa ctt        846
Lys Ala Ala Ser Ala Gly Glu Gln Leu Glu Leu Glu Lys Leu Lys Leu           
215                 220                 225                 230           

act tat gag gaa aag tgt gaa att gag gaa tcc caa ttg aag ttt ttg        894
Thr Tyr Glu Glu Lys Cys Glu Ile Glu Glu Ser Gln Leu Lys Phe Leu           
                235                 240                 245               

agg aac gac tta gct gaa tat cag aga act tgt gaa gat ctt aaa gag        942
Arg Asn Asp Leu Ala Glu Tyr Gln Arg Thr Cys Glu Asp Leu Lys Glu           
            250                 255                 260                   

caa cta aag cat aaa gaa ttt ctt ctg gct gct aat act tgt aac cgt        990
Gln Leu Lys His Lys Glu Phe Leu Leu Ala Ala Asn Thr Cys Asn Arg           
        265                 270                 275                       

gtt ggt ggt ctt tgt ttg aaa tgt gct cag cat gaa gct gtt ctt tcc       1038
Val Gly Gly Leu Cys Leu Lys Cys Ala Gln His Glu Ala Val Leu Ser           
    280                 285                 290                           

caa acc cat act aat gtt cat atg cag acc atc gaa aga ctg gtt aaa       1086
Gln Thr His Thr Asn Val His Met Gln Thr Ile Glu Arg Leu Val Lys           
295                 300                 305                 310           

gaa aga gat gac ttg atg tct gca cta gtt tcc gta agg agc agc ttg       1134
Glu Arg Asp Asp Leu Met Ser Ala Leu Val Ser Val Arg Ser Ser Leu           
                315                 320                 325               

gca gat acg cag caa aga gaa gca agt gct tat gaa cag gtg aaa caa       1182
Ala Asp Thr Gln Gln Arg Glu Ala Ser Ala Tyr Glu Gln Val Lys Gln           
            330                 335                 340                   

gtt ttg caa ata tct gag gaa gcc aat ttt gaa aaa acc aag gct tta       1230
Val Leu Gln Ile Ser Glu Glu Ala Asn Phe Glu Lys Thr Lys Ala Leu           
        345                 350                 355                       

atc cag tgt gac cag ttg agg aag gag ctg gag agg cag gcg gag cga       1278
Ile Gln Cys Asp Gln Leu Arg Lys Glu Leu Glu Arg Gln Ala Glu Arg           
    360                 365                 370                           

ctt gaa aaa gaa ctt gca tct cag caa gag aaa agg gcc att gag aaa       1326
Leu Glu Lys Glu Leu Ala Ser Gln Gln Glu Lys Arg Ala Ile Glu Lys           
375                 380                 385                 390           

gac atg atg aaa aag gaa ata acg aaa gaa agg gag tac atg gga tca       1374
Asp Met Met Lys Lys Glu Ile Thr Lys Glu Arg Glu Tyr Met Gly Ser           
                395                 400                 405               

aag atg ttg atc ttg tct cag aat att gcc caa ctg gag gcc cag gtg       1422
Lys Met Leu Ile Leu Ser Gln Asn Ile Ala Gln Leu Glu Ala Gln Val           
            410                 415                 420                   

gaa aag gtt aca aag gaa aag att tca gct att aat caa ctg gag gaa       1470
Glu Lys Val Thr Lys Glu Lys Ile Ser Ala Ile Asn Gln Leu Glu Glu           
        425                 430                 435                       

att caa agc cag ctg gct tct cgg gaa atg gat gtc aca aag gtg tgt       1518
Ile Gln Ser Gln Leu Ala Ser Arg Glu Met Asp Val Thr Lys Val Cys           
    440                 445                 450                           

gga gaa atg cgc tat cag ctg aat aaa acc aac atg gag aag gat gag       1566
Gly Glu Met Arg Tyr Gln Leu Asn Lys Thr Asn Met Glu Lys Asp Glu           
455                 460                 465                 470           

gca gaa aag gag cac aga gag ttc aga gca aaa act aac agg gat ctt       1614
Ala Glu Lys Glu His Arg Glu Phe Arg Ala Lys Thr Asn Arg Asp Leu           
                475                 480                 485               

gaa att aaa gat cag gaa ata gag aaa ttg aga ata gaa ctg gat gaa       1662
Glu Ile Lys Asp Gln Glu Ile Glu Lys Leu Arg Ile Glu Leu Asp Glu           
            490                 495                 500                   

agc aaa caa cac ttg gaa cag gag cag cag aag gca gcc ctg gcc aga       1710
Ser Lys Gln His Leu Glu Gln Glu Gln Gln Lys Ala Ala Leu Ala Arg           
        505                 510                 515                       

gag gag tgc ctg aga cta aca gaa ctg ctg ggc gaa tct gag cac caa       1758
Glu Glu Cys Leu Arg Leu Thr Glu Leu Leu Gly Glu Ser Glu His Gln           
    520                 525                 530                           

ctg cac ctc acc aga cag gaa aaa gat agc att cag cag agc ttt agc       1806
Leu His Leu Thr Arg Gln Glu Lys Asp Ser Ile Gln Gln Ser Phe Ser           
535                 540                 545                 550           

aag gaa gca aag gcc caa gcc ctt cag gcc cag caa aga gag cag gag       1854
Lys Glu Ala Lys Ala Gln Ala Leu Gln Ala Gln Gln Arg Glu Gln Glu           
                555                 560                 565               

ctg aca cag aag ata cag caa atg gag gcc cag cat gac aaa act gaa       1902
Leu Thr Gln Lys Ile Gln Gln Met Glu Ala Gln His Asp Lys Thr Glu           
            570                 575                 580                   

aat gaa cag tat ttg ttg ctg acc tcc cag aat aca ttt ttg aca aag       1950
Asn Glu Gln Tyr Leu Leu Leu Thr Ser Gln Asn Thr Phe Leu Thr Lys           
        585                 590                 595                       

tta aag gaa gaa tgc tgt aca tta gcc aag aaa ctg gaa caa atc tct       1998
Leu Lys Glu Glu Cys Cys Thr Leu Ala Lys Lys Leu Glu Gln Ile Ser           
    600                 605                 610                           

caa aaa acc aga tct gaa ata gct caa ctc agt caa gaa aaa agg tat       2046
Gln Lys Thr Arg Ser Glu Ile Ala Gln Leu Ser Gln Glu Lys Arg Tyr           
615                 620                 625                 630           

aca tat gat aaa ttg gga aag tta cag aga aga aat gaa gaa ttg gag       2094
Thr Tyr Asp Lys Leu Gly Lys Leu Gln Arg Arg Asn Glu Glu Leu Glu           
                635                 640                 645               

gaa cag tgt gtc cag cat ggg aga gta cat gag acg atg aag caa agg       2142
Glu Gln Cys Val Gln His Gly Arg Val His Glu Thr Met Lys Gln Arg           
            650                 655                 660                   

cta agg cag ctg gat aag cac agc cag gcc aca gcc cag cag ctg gtg       2190
Leu Arg Gln Leu Asp Lys His Ser Gln Ala Thr Ala Gln Gln Leu Val           
        665                 670                 675                       

cag ctc ctc agc aag cag aac cag ctt ctc ctg gag agg cag agc ctg       2238
Gln Leu Leu Ser Lys Gln Asn Gln Leu Leu Leu Glu Arg Gln Ser Leu           
    680                 685                 690                           

tcg gaa gag gtg gac cgg ctg cgg acc cag tta ccc agc atg cca caa       2286
Ser Glu Glu Val Asp Arg Leu Arg Thr Gln Leu Pro Ser Met Pro Gln           
695                 700                 705                 710           

tct gat tgc tga cctggatgga acagagtgaa ataaatgatt tacaaagaga           2338
Ser Asp Cys                                                               
                                                                          

tatttacatt catctggttt agacttaata tgccacaacg caccacgacc ttcccagggt     2398

gacaccgcct cagcctgcag tggggctggt cctcatcaac gcgggcgctg tccccgcacg     2458

cagtcgggct ggagctggag tctgactcta gctgagcaga gctcctggtg tatgttttca     2518

gaaatggctt gaagttatgt gtttaaatct gctcattcgt atgctaggtt atacatatga     2578

ttttcaataa atgaactttt taaagaaaaa aaaaaa                               2614


<210>  372
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  372

Met Ala Lys Ser Pro Glu Asn Ser Thr Leu Glu Glu Ile Leu Gly Gln 
1               5                   10                  15      


Tyr Gln Arg Ser Leu Arg Glu His Ala Ser Arg Ser Ile His Gln Leu 
            20                  25                  30          


Thr Cys Ala Leu Lys Glu Gly Asp Val Thr Ile Gly Glu Asp Ala Pro 
        35                  40                  45              


Asn Leu Ser Phe Ser Thr Ser Val Gly Asn Glu Asp Ala Arg Thr Ala 
    50                  55                  60                  


Trp Pro Glu Leu Gln Gln Ser His Ala Val Asn Gln Leu Lys Asp Leu 
65                  70                  75                  80  


Leu Arg Gln Gln Ala Asp Lys Glu Ser Glu Val Ser Pro Ser Arg Arg 
                85                  90                  95      


Arg Lys Met Ser Pro Leu Arg Ser Leu Glu His Glu Glu Thr Asn Met 
            100                 105                 110         


Pro Thr Met His Asp Leu Val His Thr Ile Asn Asp Gln Ser Gln Tyr 
        115                 120                 125             


Ile His His Leu Glu Ala Glu Val Lys Phe Cys Lys Glu Glu Leu Ser 
    130                 135                 140                 


Gly Met Lys Asn Lys Ile Gln Val Val Val Leu Glu Asn Glu Gly Leu 
145                 150                 155                 160 


Gln Gln Gln Leu Lys Ser Gln Arg Gln Glu Glu Thr Leu Arg Glu Gln 
                165                 170                 175     


Thr Leu Leu Asp Ala Ser Gly Asn Met His Asn Ser Trp Ile Thr Thr 
            180                 185                 190         


Gly Glu Asp Ser Gly Val Gly Glu Thr Ser Lys Arg Pro Phe Ser His 
        195                 200                 205             


Asp Asn Ala Asp Phe Gly Lys Ala Ala Ser Ala Gly Glu Gln Leu Glu 
    210                 215                 220                 


Leu Glu Lys Leu Lys Leu Thr Tyr Glu Glu Lys Cys Glu Ile Glu Glu 
225                 230                 235                 240 


Ser Gln Leu Lys Phe Leu Arg Asn Asp Leu Ala Glu Tyr Gln Arg Thr 
                245                 250                 255     


Cys Glu Asp Leu Lys Glu Gln Leu Lys His Lys Glu Phe Leu Leu Ala 
            260                 265                 270         


Ala Asn Thr Cys Asn Arg Val Gly Gly Leu Cys Leu Lys Cys Ala Gln 
        275                 280                 285             


His Glu Ala Val Leu Ser Gln Thr His Thr Asn Val His Met Gln Thr 
    290                 295                 300                 


Ile Glu Arg Leu Val Lys Glu Arg Asp Asp Leu Met Ser Ala Leu Val 
305                 310                 315                 320 


Ser Val Arg Ser Ser Leu Ala Asp Thr Gln Gln Arg Glu Ala Ser Ala 
                325                 330                 335     


Tyr Glu Gln Val Lys Gln Val Leu Gln Ile Ser Glu Glu Ala Asn Phe 
            340                 345                 350         


Glu Lys Thr Lys Ala Leu Ile Gln Cys Asp Gln Leu Arg Lys Glu Leu 
        355                 360                 365             


Glu Arg Gln Ala Glu Arg Leu Glu Lys Glu Leu Ala Ser Gln Gln Glu 
    370                 375                 380                 


Lys Arg Ala Ile Glu Lys Asp Met Met Lys Lys Glu Ile Thr Lys Glu 
385                 390                 395                 400 


Arg Glu Tyr Met Gly Ser Lys Met Leu Ile Leu Ser Gln Asn Ile Ala 
                405                 410                 415     


Gln Leu Glu Ala Gln Val Glu Lys Val Thr Lys Glu Lys Ile Ser Ala 
            420                 425                 430         


Ile Asn Gln Leu Glu Glu Ile Gln Ser Gln Leu Ala Ser Arg Glu Met 
        435                 440                 445             


Asp Val Thr Lys Val Cys Gly Glu Met Arg Tyr Gln Leu Asn Lys Thr 
    450                 455                 460                 


Asn Met Glu Lys Asp Glu Ala Glu Lys Glu His Arg Glu Phe Arg Ala 
465                 470                 475                 480 


Lys Thr Asn Arg Asp Leu Glu Ile Lys Asp Gln Glu Ile Glu Lys Leu 
                485                 490                 495     


Arg Ile Glu Leu Asp Glu Ser Lys Gln His Leu Glu Gln Glu Gln Gln 
            500                 505                 510         


Lys Ala Ala Leu Ala Arg Glu Glu Cys Leu Arg Leu Thr Glu Leu Leu 
        515                 520                 525             


Gly Glu Ser Glu His Gln Leu His Leu Thr Arg Gln Glu Lys Asp Ser 
    530                 535                 540                 


Ile Gln Gln Ser Phe Ser Lys Glu Ala Lys Ala Gln Ala Leu Gln Ala 
545                 550                 555                 560 


Gln Gln Arg Glu Gln Glu Leu Thr Gln Lys Ile Gln Gln Met Glu Ala 
                565                 570                 575     


Gln His Asp Lys Thr Glu Asn Glu Gln Tyr Leu Leu Leu Thr Ser Gln 
            580                 585                 590         


Asn Thr Phe Leu Thr Lys Leu Lys Glu Glu Cys Cys Thr Leu Ala Lys 
        595                 600                 605             


Lys Leu Glu Gln Ile Ser Gln Lys Thr Arg Ser Glu Ile Ala Gln Leu 
    610                 615                 620                 


Ser Gln Glu Lys Arg Tyr Thr Tyr Asp Lys Leu Gly Lys Leu Gln Arg 
625                 630                 635                 640 


Arg Asn Glu Glu Leu Glu Glu Gln Cys Val Gln His Gly Arg Val His 
                645                 650                 655     


Glu Thr Met Lys Gln Arg Leu Arg Gln Leu Asp Lys His Ser Gln Ala 
            660                 665                 670         


Thr Ala Gln Gln Leu Val Gln Leu Leu Ser Lys Gln Asn Gln Leu Leu 
        675                 680                 685             


Leu Glu Arg Gln Ser Leu Ser Glu Glu Val Asp Arg Leu Arg Thr Gln 
    690                 695                 700                 


Leu Pro Ser Met Pro Gln Ser Asp Cys 
705                 710             


<210>  373
<211>  2408
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (238)..(825)

<400>  373
gggtgcgcgg gcacgcggga ctcccagctg tcaatcaggc gcgggctgag ctctacgagg       60

cggagcggcg gcggtggcga cggcgatggg accccagcga gagatctgca gctaggctgg      120

ctgcacttgc tccacgggtc aggggatcgg agggggattg aagaatgcgc cattaaaagg      180

aaagatcaag gagtaaacca gaagaagaag aaaaagagga cttcaaagct gggaagg         237

atg agt tct tgc agc aac gtc tgt ggg tcc agg cag gca cag gct gca        285
Met Ser Ser Cys Ser Asn Val Cys Gly Ser Arg Gln Ala Gln Ala Ala           
1               5                   10                  15                

gct gag ggt ggt tac cag cgc tat gga gtc cgg tcc tac ctg cac cag        333
Ala Glu Gly Gly Tyr Gln Arg Tyr Gly Val Arg Ser Tyr Leu His Gln           
            20                  25                  30                    

ttt tat gag gac tgt aca gcc tca att tgg gag tat gag gat gat ttc        381
Phe Tyr Glu Asp Cys Thr Ala Ser Ile Trp Glu Tyr Glu Asp Asp Phe           
        35                  40                  45                        

cag atc caa aga tca cct aac agg tgg agc tca gta ttc tgg aag gtt        429
Gln Ile Gln Arg Ser Pro Asn Arg Trp Ser Ser Val Phe Trp Lys Val           
    50                  55                  60                            

gga ctc atc tca ggt aca gtt ttt gtg atc ctc gga ttg act gtt ctg        477
Gly Leu Ile Ser Gly Thr Val Phe Val Ile Leu Gly Leu Thr Val Leu           
65                  70                  75                  80            

gca gtg ggc ttt ctt gtg ccc ccc aaa atc gaa gca ttt ggc gaa gcc        525
Ala Val Gly Phe Leu Val Pro Pro Lys Ile Glu Ala Phe Gly Glu Ala           
                85                  90                  95                

gat ttt gtg gtg gtc gac aca cat gct gtc cag ttt aac agt gct ctg        573
Asp Phe Val Val Val Asp Thr His Ala Val Gln Phe Asn Ser Ala Leu           
            100                 105                 110                   

gac atg tac aag ctg gca gga gct gtt ctc ttc tgc att gga ggc acg        621
Asp Met Tyr Lys Leu Ala Gly Ala Val Leu Phe Cys Ile Gly Gly Thr           
        115                 120                 125                       

tcc atg gca ggg tgc ctg ctg atg tcg gtg ttt gta aag agc tac tcc        669
Ser Met Ala Gly Cys Leu Leu Met Ser Val Phe Val Lys Ser Tyr Ser           
    130                 135                 140                           

aaa gaa gaa aaa ttc ctc cag cag aag ttt aaa gaa cga atc gca gac        717
Lys Glu Glu Lys Phe Leu Gln Gln Lys Phe Lys Glu Arg Ile Ala Asp           
145                 150                 155                 160           

atc aaa gcc cac acc cag ccg gtt aca aaa gct cca ggg cca ggg gaa        765
Ile Lys Ala His Thr Gln Pro Val Thr Lys Ala Pro Gly Pro Gly Glu           
                165                 170                 175               

aca aag att cca gtc act ttg tcc agg gtt caa aat gtc cag cct cta        813
Thr Lys Ile Pro Val Thr Leu Ser Arg Val Gln Asn Val Gln Pro Leu           
            180                 185                 190                   

ctg gca acc tga aacctttccc accccagttc ttcttgtctg atttatgccc            865
Leu Ala Thr                                                               
        195                                                               

gtggttaaaa agagcaggcc agttttcgag ataaagaaga tttggcgttg actgccctag      925

ggctgtgttc agctgtgggc aatataatgg gtggactcac acttgctcag ttcaggcagc      985

tctgctggag ggcggtgcca tgcctaagcc tgtgcacatg catccagctg cttaagatgg     1045

gtgcttcctt gtacccggcc accagaaaac ccctggaact cctctttcat agatcgtgac     1105

tttgtgttat tttccgtgtt gtttgaaagt gccgaacagt ttagaccagc tcaccaatgg     1165

ctaatgtggt ccattttatt ttctaatatt ggtttatcta atgttttctg cgtggtgctg     1225

tcttccattc ctgtctcact atgtgtaaga ttttgtcata tgtgttcata gaaacatgga     1285

attctctgat tttgagccga acatgagttt ttagactgta tcttgacatg aggttcctga     1345

cattggatac aaagttatca gcattcacaa atctttttgt tttctccatt ttttttccct     1405

ttgagatgaa gtgctgttct tttgcctagg ttggagtaca gcggtgaaat catagcgcac     1465

tgcagccttg aactcctggg ctcaagcgat cctcccacct cagcctccca agtagctggg     1525

actacaggca cctgccacca cccccagtta atattttttt taattttttt tagaggcagg     1585

atcttgctgt ccaatttttt ttaaaaagct aaaattgcca actttagaat cttgaccaaa     1645

aaaaattaat tttaggagca tctatttatg cagtgttcaa aagtactgaa ttagaaacca     1705

ggaagtttta gttccttcta ctacctgtgt gatcttgggg aaattattta acctctcagt     1765

cctaattttc cccttctgta taatgggagt tctggatcac aatatgtctg ggctctcatt     1825

acccaaacat ctgagattcc atttttgcca tgtgtcatcg agtcgctccc caacagatgt     1885

ttgtgatgtt tttgtggctg tcaccatggt gggattcttt cagaatgaga ctcctggaaa     1945

ttcactgagt cagcagcctt cacaccatct acccttaaat atccaacccc agcaatttat     2005

acaacgctgt catattttta aaaaaacaaa agtaagccat cctcaaataa ggaacccctt     2065

ggtagatatt aaccttaaaa agggttttca ttctcaaaca agatgctttg ttctccaaca     2125

agatgttcat ctcatcactt gcacttttgt tttaatgtat ggattcagat tagactgaga     2185

aaaatggatg gtattttctt aaaattgtgc caccttagag ccccccccct tttttttttc     2245

ttccttcact ggataaataa aatatgtgaa caagtggaac ctgaattgca ttgtcattcc     2305

ttcagtgtgg ttattttctc tccaacatgt aattttccat tctgagactg aataagctct     2365

gatgtttccc cggctaaatg gaagaataaa tgaagcaatt agt                       2408


<210>  374
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  374

Met Ser Ser Cys Ser Asn Val Cys Gly Ser Arg Gln Ala Gln Ala Ala 
1               5                   10                  15      


Ala Glu Gly Gly Tyr Gln Arg Tyr Gly Val Arg Ser Tyr Leu His Gln 
            20                  25                  30          


Phe Tyr Glu Asp Cys Thr Ala Ser Ile Trp Glu Tyr Glu Asp Asp Phe 
        35                  40                  45              


Gln Ile Gln Arg Ser Pro Asn Arg Trp Ser Ser Val Phe Trp Lys Val 
    50                  55                  60                  


Gly Leu Ile Ser Gly Thr Val Phe Val Ile Leu Gly Leu Thr Val Leu 
65                  70                  75                  80  


Ala Val Gly Phe Leu Val Pro Pro Lys Ile Glu Ala Phe Gly Glu Ala 
                85                  90                  95      


Asp Phe Val Val Val Asp Thr His Ala Val Gln Phe Asn Ser Ala Leu 
            100                 105                 110         


Asp Met Tyr Lys Leu Ala Gly Ala Val Leu Phe Cys Ile Gly Gly Thr 
        115                 120                 125             


Ser Met Ala Gly Cys Leu Leu Met Ser Val Phe Val Lys Ser Tyr Ser 
    130                 135                 140                 


Lys Glu Glu Lys Phe Leu Gln Gln Lys Phe Lys Glu Arg Ile Ala Asp 
145                 150                 155                 160 


Ile Lys Ala His Thr Gln Pro Val Thr Lys Ala Pro Gly Pro Gly Glu 
                165                 170                 175     


Thr Lys Ile Pro Val Thr Leu Ser Arg Val Gln Asn Val Gln Pro Leu 
            180                 185                 190         


Leu Ala Thr 
        195 


<210>  375
<211>  3837
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (127)..(1887)

<400>  375
actccagacg gcgggccgcc ccctcttccc gccttcctac taccggccca ggattagcgc       60

cctgggagcg cgcgccccgc tgcctcgccg ccacactttc ctgggagcgg cggccacgga      120

ggcacc atg aag aag tct tac tca gga ggc acg cgg acc tcc agt ggc         168
       Met Lys Lys Ser Tyr Ser Gly Gly Thr Arg Thr Ser Ser Gly            
       1               5                   10                             

cgg ctc cgg agg ctt ggt gac tcc agt ggc cca gcc ttg aaa aga tct        216
Arg Leu Arg Arg Leu Gly Asp Ser Ser Gly Pro Ala Leu Lys Arg Ser           
15                  20                  25                  30            

ttt gag gtc gag gag gtc gag aca ccc aac tcc acc cca ccc cgg agg        264
Phe Glu Val Glu Glu Val Glu Thr Pro Asn Ser Thr Pro Pro Arg Arg           
                35                  40                  45                

gtc cag act ccc cta ctc cga gcc act gtg gcc agc tcc acc cag aaa        312
Val Gln Thr Pro Leu Leu Arg Ala Thr Val Ala Ser Ser Thr Gln Lys           
            50                  55                  60                    

ttc cag gac ctg ggc gtg aag aac tca gaa ccc tcg gcc cgc cat gtg        360
Phe Gln Asp Leu Gly Val Lys Asn Ser Glu Pro Ser Ala Arg His Val           
        65                  70                  75                        

gac tcc cta agc caa cgc tcc ccc aag gcg tcc ctg cgg agg gtg gag        408
Asp Ser Leu Ser Gln Arg Ser Pro Lys Ala Ser Leu Arg Arg Val Glu           
    80                  85                  90                            

ctc tcg ggc ccc aag gcg gcc gag ccg gtg tcc cgg cgc act gag ctg        456
Leu Ser Gly Pro Lys Ala Ala Glu Pro Val Ser Arg Arg Thr Glu Leu           
95                  100                 105                 110           

tcc att gac atc tcg tcc aag cag gtg gag aac gcc ggg gcc atc ggc        504
Ser Ile Asp Ile Ser Ser Lys Gln Val Glu Asn Ala Gly Ala Ile Gly           
                115                 120                 125               

ccg tcc cgg ttc ggg ctc aag agg gcc gag gtg ttg ggc cac aag acg        552
Pro Ser Arg Phe Gly Leu Lys Arg Ala Glu Val Leu Gly His Lys Thr           
            130                 135                 140                   

cca gaa ccg gcc cct cgg agg acg gag atc acc atc gtc aaa ccc cag        600
Pro Glu Pro Ala Pro Arg Arg Thr Glu Ile Thr Ile Val Lys Pro Gln           
        145                 150                 155                       

gag tca gcc cac cgg agg atg gag ccc cct gcc tcc aag gtc ccc gag        648
Glu Ser Ala His Arg Arg Met Glu Pro Pro Ala Ser Lys Val Pro Glu           
    160                 165                 170                           

gtg ccc act gcc cct gcc acc gac gca gcc ccc aag agg gtg gag atc        696
Val Pro Thr Ala Pro Ala Thr Asp Ala Ala Pro Lys Arg Val Glu Ile           
175                 180                 185                 190           

cag atg ccc aag cct gct gag gcg ccc acc gcc ccc agc cca gcc cag        744
Gln Met Pro Lys Pro Ala Glu Ala Pro Thr Ala Pro Ser Pro Ala Gln           
                195                 200                 205               

acc ttg gag aat tca gag cct gcc cct gtg tct cag ctg cag agc agg        792
Thr Leu Glu Asn Ser Glu Pro Ala Pro Val Ser Gln Leu Gln Ser Arg           
            210                 215                 220                   

ctg gag ccc aag ccc cag ccc cct gtg gct gag gct aca ccc cgg agc        840
Leu Glu Pro Lys Pro Gln Pro Pro Val Ala Glu Ala Thr Pro Arg Ser           
        225                 230                 235                       

cag gag gcc act gag gcg gct ccc agc tgc gtt ggc gac atg gcc gac        888
Gln Glu Ala Thr Glu Ala Ala Pro Ser Cys Val Gly Asp Met Ala Asp           
    240                 245                 250                           

acc ccc aga gat gcc ggg ctc aag cag gcg cct gca tca cgg aac gag        936
Thr Pro Arg Asp Ala Gly Leu Lys Gln Ala Pro Ala Ser Arg Asn Glu           
255                 260                 265                 270           

aag gcc ccg gtg gac ttc ggc tac gtg ggg att gac tcc atc ctg gag        984
Lys Ala Pro Val Asp Phe Gly Tyr Val Gly Ile Asp Ser Ile Leu Glu           
                275                 280                 285               

cag atg cgc cgg aag gcc atg aag cag ggc ttc gag ttc aac atc atg       1032
Gln Met Arg Arg Lys Ala Met Lys Gln Gly Phe Glu Phe Asn Ile Met           
            290                 295                 300                   

gtg gtc ggg cag agc ggc ttg ggt aaa tcc acc tta atc aac acc ctc       1080
Val Val Gly Gln Ser Gly Leu Gly Lys Ser Thr Leu Ile Asn Thr Leu           
        305                 310                 315                       

ttc aaa tcc aaa atc agc cgg aag tcg gtg cag ccc acc tca gag gag       1128
Phe Lys Ser Lys Ile Ser Arg Lys Ser Val Gln Pro Thr Ser Glu Glu           
    320                 325                 330                           

cgc atc ccc aag acc atc gag atc aag tcc atc acg cac gat att gag       1176
Arg Ile Pro Lys Thr Ile Glu Ile Lys Ser Ile Thr His Asp Ile Glu           
335                 340                 345                 350           

gag aaa ggc gtc cgg atg aag ctg aca gtg att gac aca cca ggg ttc       1224
Glu Lys Gly Val Arg Met Lys Leu Thr Val Ile Asp Thr Pro Gly Phe           
                355                 360                 365               

ggg gac cac atc aac aac gag aac tgc tgg cag ccc atc atg aag ttc       1272
Gly Asp His Ile Asn Asn Glu Asn Cys Trp Gln Pro Ile Met Lys Phe           
            370                 375                 380                   

atc aat gac cag tac gag aaa tac ctg cag gag gag gtc aac atc aac       1320
Ile Asn Asp Gln Tyr Glu Lys Tyr Leu Gln Glu Glu Val Asn Ile Asn           
        385                 390                 395                       

cgc aag aag cgc atc ccg gac acc cgc gtc cac tgc tgc ctc tac ttc       1368
Arg Lys Lys Arg Ile Pro Asp Thr Arg Val His Cys Cys Leu Tyr Phe           
    400                 405                 410                           

atc ccc gcc acc ggc cac tcc ctc agg ccc ctg gac atc gag ttt atg       1416
Ile Pro Ala Thr Gly His Ser Leu Arg Pro Leu Asp Ile Glu Phe Met           
415                 420                 425                 430           

aaa cgc ctg agc aag gtg gtc aac atc gtc cct gtc atc gcc aag gcg       1464
Lys Arg Leu Ser Lys Val Val Asn Ile Val Pro Val Ile Ala Lys Ala           
                435                 440                 445               

gac aca ctc acc ctg gag gag agg gtc cac ttc aaa cag cgg atc acc       1512
Asp Thr Leu Thr Leu Glu Glu Arg Val His Phe Lys Gln Arg Ile Thr           
            450                 455                 460                   

gca gac ctg ctg tcc aac ggc atc gac gtg tac ccc cag aag gaa ttt       1560
Ala Asp Leu Leu Ser Asn Gly Ile Asp Val Tyr Pro Gln Lys Glu Phe           
        465                 470                 475                       

gat gag gac tcg gag gac cgg ctg gtg aac gag aag ttc cgg gag atg       1608
Asp Glu Asp Ser Glu Asp Arg Leu Val Asn Glu Lys Phe Arg Glu Met           
    480                 485                 490                           

atc cca ttt gct gtg gtg ggc agt gac cac gag tac cag gtc aac ggc       1656
Ile Pro Phe Ala Val Val Gly Ser Asp His Glu Tyr Gln Val Asn Gly           
495                 500                 505                 510           

aag agg atc ctt ggg agg aag acc aag tgg ggt acc atc gaa gtt gaa       1704
Lys Arg Ile Leu Gly Arg Lys Thr Lys Trp Gly Thr Ile Glu Val Glu           
                515                 520                 525               

aac acc aca cac tgt gag ttt gcc tac ctg cgg gac ctt ctc atc agg       1752
Asn Thr Thr His Cys Glu Phe Ala Tyr Leu Arg Asp Leu Leu Ile Arg           
            530                 535                 540                   

acg cac atg cag aac atc aag gac atc acc agc agc atc cac ttc gag       1800
Thr His Met Gln Asn Ile Lys Asp Ile Thr Ser Ser Ile His Phe Glu           
        545                 550                 555                       

gcg tac cgt gtg aag cgc ctc aac gag ggc agc agc gcc atg gcc aac       1848
Ala Tyr Arg Val Lys Arg Leu Asn Glu Gly Ser Ser Ala Met Ala Asn           
    560                 565                 570                           

ggc atg gag gag aag gag cca gaa gcc ccg gag atg tag acgccaccct        1897
Gly Met Glu Glu Lys Glu Pro Glu Ala Pro Glu Met                           
575                 580                 585                               

gcccaccccc gggatcctgc ccccaagtca tttccgtccc cccccaggcc ctcccaccac     1957

cccattttat tttatatgat tttctccatt tgtcatcgtt ccccacccct tcgacatgct     2017

gccaggaaac aagggaaggg gcctccctcc gagtgagtca gtgatgaggc cgcggcctcc     2077

ccgaggttgt ggggaggctg cactggagcc acaggcaggg gtgagagcac ccactgaatt     2137

gacatgaccc tctgtcccca ggcctggctc cccgagggct cagaagagca gcttcggtgt     2197

gcagatcatc cgtctgtgtg gggttctcag tgccggaggc cttggggtgg gggccaggcc     2257

tcgcacttgc agaggagccc agtgggctgc acgctcccct ccatccccat cggccctgtc     2317

ccctggagtg tgtcagagcc caggggagaa tgcagcccac caggagcacc tggaccccct     2377

gcccgccaca tggtgtggcc atcactcagc ccctacccct gccctgctcc taagggtaga     2437

aaactccagg gtcccctgcc accgactgcc cagccactcc aagccccctg gcagctgccc     2497

ctcctggagc agaaagtgcc tttatctcag ccatccgcag actgcttggc cagatgcggg     2557

gacaggctgg aatgagggag gcgtcttcat ctccctgcca tccccctctc acgccacccc     2617

cgcccccacc gggctgcagg tgctgctgat gcgctgggat ctgattgagg ataaaaagga     2677

aggagagatg acccctaccc cctcatcccc cagttttgaa aaggtctaag caagtgagtc     2737

tggtggagga gctgagggag ggagccatgg aaggtgccag aaggaaggtt ggcgggggca     2797

cgtgtgggcc gtggcttggg ctggtcagag tggcgtgagc tgcccggcgc ctgccctgcc     2857

caagtgacca gggaagtgtg tgtgtgtcca tgtgtatgcg tgtccgtctg tctgtctagt     2917

gtctgggttt ggcccaagac tgggctgtag ttacattaat gcccagccag ccacccctgc     2977

cactcacccc tcctggccca ggccttgctg actctctgag ctggggaggt gggaggccag     3037

gcgagcctga ctctgttgat ctacccgtgc ctgggcccct cccctcagag cccatggtaa     3097

cgaaccccta gaaaggagag aacgggcgtc aggggtgcac agtccacagc tgaagagcaa     3157

ggtttcgtgg cagcacggcc cggcccctca ccctctgtcc ccacgagggg acccatgggg     3217

gctgtctttg cagggcacag atgaccaaag tcccttcctg cttcctgtta cctgtcttgc     3277

tcctggggag aaagaggggc ctgatgagac tccactcagg tgcacacatc accaggtgca     3337

tctgcaggca ccgggctggc tgcttgcagc caggagaagg tcagcgagaa ggagtgtatg     3397

agtgtgagtg tgtgtgcatg gaagttgggg cactgggcgt ctgactccct ccccacccaa     3457

gagaggaagg acccctcacc acccccactg gcgagacagt ttactttgcc gacttgccat     3517

gtttttgcca aaaccaagat tttgaaggaa atgagtggcc agcgccaggg cccaggccat     3577

gtggcctgcc cagcctcaat gtcacttggt ggcggggtgg ggtgggggtg ggcagcagca     3637

tcccagcctt gagatgcttc actttccttc tctgtaacca gactttgaaa aattgttcgt     3697

ttcatcaggc tctgttcctc aatggccttt tgctacgtgc ctcccgagaa atttgtcttt     3757

ttgtataaat gacaaagtgt tgaaaatgta tttcctgaaa taaatgtttc aaatgcagaa     3817

acccagaaaa aaaaaaaaaa                                                 3837


<210>  376
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  376

Met Lys Lys Ser Tyr Ser Gly Gly Thr Arg Thr Ser Ser Gly Arg Leu 
1               5                   10                  15      


Arg Arg Leu Gly Asp Ser Ser Gly Pro Ala Leu Lys Arg Ser Phe Glu 
            20                  25                  30          


Val Glu Glu Val Glu Thr Pro Asn Ser Thr Pro Pro Arg Arg Val Gln 
        35                  40                  45              


Thr Pro Leu Leu Arg Ala Thr Val Ala Ser Ser Thr Gln Lys Phe Gln 
    50                  55                  60                  


Asp Leu Gly Val Lys Asn Ser Glu Pro Ser Ala Arg His Val Asp Ser 
65                  70                  75                  80  


Leu Ser Gln Arg Ser Pro Lys Ala Ser Leu Arg Arg Val Glu Leu Ser 
                85                  90                  95      


Gly Pro Lys Ala Ala Glu Pro Val Ser Arg Arg Thr Glu Leu Ser Ile 
            100                 105                 110         


Asp Ile Ser Ser Lys Gln Val Glu Asn Ala Gly Ala Ile Gly Pro Ser 
        115                 120                 125             


Arg Phe Gly Leu Lys Arg Ala Glu Val Leu Gly His Lys Thr Pro Glu 
    130                 135                 140                 


Pro Ala Pro Arg Arg Thr Glu Ile Thr Ile Val Lys Pro Gln Glu Ser 
145                 150                 155                 160 


Ala His Arg Arg Met Glu Pro Pro Ala Ser Lys Val Pro Glu Val Pro 
                165                 170                 175     


Thr Ala Pro Ala Thr Asp Ala Ala Pro Lys Arg Val Glu Ile Gln Met 
            180                 185                 190         


Pro Lys Pro Ala Glu Ala Pro Thr Ala Pro Ser Pro Ala Gln Thr Leu 
        195                 200                 205             


Glu Asn Ser Glu Pro Ala Pro Val Ser Gln Leu Gln Ser Arg Leu Glu 
    210                 215                 220                 


Pro Lys Pro Gln Pro Pro Val Ala Glu Ala Thr Pro Arg Ser Gln Glu 
225                 230                 235                 240 


Ala Thr Glu Ala Ala Pro Ser Cys Val Gly Asp Met Ala Asp Thr Pro 
                245                 250                 255     


Arg Asp Ala Gly Leu Lys Gln Ala Pro Ala Ser Arg Asn Glu Lys Ala 
            260                 265                 270         


Pro Val Asp Phe Gly Tyr Val Gly Ile Asp Ser Ile Leu Glu Gln Met 
        275                 280                 285             


Arg Arg Lys Ala Met Lys Gln Gly Phe Glu Phe Asn Ile Met Val Val 
    290                 295                 300                 


Gly Gln Ser Gly Leu Gly Lys Ser Thr Leu Ile Asn Thr Leu Phe Lys 
305                 310                 315                 320 


Ser Lys Ile Ser Arg Lys Ser Val Gln Pro Thr Ser Glu Glu Arg Ile 
                325                 330                 335     


Pro Lys Thr Ile Glu Ile Lys Ser Ile Thr His Asp Ile Glu Glu Lys 
            340                 345                 350         


Gly Val Arg Met Lys Leu Thr Val Ile Asp Thr Pro Gly Phe Gly Asp 
        355                 360                 365             


His Ile Asn Asn Glu Asn Cys Trp Gln Pro Ile Met Lys Phe Ile Asn 
    370                 375                 380                 


Asp Gln Tyr Glu Lys Tyr Leu Gln Glu Glu Val Asn Ile Asn Arg Lys 
385                 390                 395                 400 


Lys Arg Ile Pro Asp Thr Arg Val His Cys Cys Leu Tyr Phe Ile Pro 
                405                 410                 415     


Ala Thr Gly His Ser Leu Arg Pro Leu Asp Ile Glu Phe Met Lys Arg 
            420                 425                 430         


Leu Ser Lys Val Val Asn Ile Val Pro Val Ile Ala Lys Ala Asp Thr 
        435                 440                 445             


Leu Thr Leu Glu Glu Arg Val His Phe Lys Gln Arg Ile Thr Ala Asp 
    450                 455                 460                 


Leu Leu Ser Asn Gly Ile Asp Val Tyr Pro Gln Lys Glu Phe Asp Glu 
465                 470                 475                 480 


Asp Ser Glu Asp Arg Leu Val Asn Glu Lys Phe Arg Glu Met Ile Pro 
                485                 490                 495     


Phe Ala Val Val Gly Ser Asp His Glu Tyr Gln Val Asn Gly Lys Arg 
            500                 505                 510         


Ile Leu Gly Arg Lys Thr Lys Trp Gly Thr Ile Glu Val Glu Asn Thr 
        515                 520                 525             


Thr His Cys Glu Phe Ala Tyr Leu Arg Asp Leu Leu Ile Arg Thr His 
    530                 535                 540                 


Met Gln Asn Ile Lys Asp Ile Thr Ser Ser Ile His Phe Glu Ala Tyr 
545                 550                 555                 560 


Arg Val Lys Arg Leu Asn Glu Gly Ser Ser Ala Met Ala Asn Gly Met 
                565                 570                 575     


Glu Glu Lys Glu Pro Glu Ala Pro Glu Met 
            580                 585     


<210>  377
<211>  2453
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (225)..(1277)

<400>  377
cagacatgag ctgtgagggt caagcacagc tatccatcag atgatctact ttcagccttc       60

ctgagtccca gacaatagaa gacaggtggc tgtacccttg gccaagggta ggtgtggcag      120

tggtgtctgc tgtcactgtg ccctcattgg cccccagcaa tcagactcaa cagacggagc      180

aactgccatc cgaggctcct gaaccagggc cattcaccag gagc atg cgg ctc cct       236
                                                 Met Arg Leu Pro          
                                                 1                        

gat gtc cag ctc tgg ctg gtg ctg ctg tgg gca ctg gtg cga gca cag        284
Asp Val Gln Leu Trp Leu Val Leu Leu Trp Ala Leu Val Arg Ala Gln           
5                   10                  15                  20            

ggg aca ggg tct gtg tgt ccc tcc tgt ggg ggc tcc aaa ctg gca ccc        332
Gly Thr Gly Ser Val Cys Pro Ser Cys Gly Gly Ser Lys Leu Ala Pro           
                25                  30                  35                

caa gca gaa cga gct ctg gtg ctg gag cta gcc aag cag caa atc ctg        380
Gln Ala Glu Arg Ala Leu Val Leu Glu Leu Ala Lys Gln Gln Ile Leu           
            40                  45                  50                    

gat ggg ttg cac ctg acc agt cgt ccc aga ata act cat cct cca ccc        428
Asp Gly Leu His Leu Thr Ser Arg Pro Arg Ile Thr His Pro Pro Pro           
        55                  60                  65                        

cag gca gcg ctg acc aga gcc ctc cgg aga cta cag cca ggg agt gtg        476
Gln Ala Ala Leu Thr Arg Ala Leu Arg Arg Leu Gln Pro Gly Ser Val           
    70                  75                  80                            

gct cca ggg aat ggg gag gag gtc atc agc ttt gct act gtc aca gac        524
Ala Pro Gly Asn Gly Glu Glu Val Ile Ser Phe Ala Thr Val Thr Asp           
85                  90                  95                  100           

tcc act tca gcc tac agc tcc ctg ctc act ttt cac ctg tcc act cct        572
Ser Thr Ser Ala Tyr Ser Ser Leu Leu Thr Phe His Leu Ser Thr Pro           
                105                 110                 115               

cgg tcc cac cac ctg tac cat gcc cgc ctg tgg ctg cac gtg ctc ccc        620
Arg Ser His His Leu Tyr His Ala Arg Leu Trp Leu His Val Leu Pro           
            120                 125                 130                   

acc ctt cct ggc act ctt tgc ttg agg atc ttc cga tgg gga cca agg        668
Thr Leu Pro Gly Thr Leu Cys Leu Arg Ile Phe Arg Trp Gly Pro Arg           
        135                 140                 145                       

agg agg cgc caa ggg tcc cgc act ctc ctg gct gag cac cac atc acc        716
Arg Arg Arg Gln Gly Ser Arg Thr Leu Leu Ala Glu His His Ile Thr           
    150                 155                 160                           

aac ctg ggc tgg cat acc tta act ctg ccc tct agt ggc ttg agg ggt        764
Asn Leu Gly Trp His Thr Leu Thr Leu Pro Ser Ser Gly Leu Arg Gly           
165                 170                 175                 180           

gag aag tct ggt gtc ctg aaa ctg caa cta gac tgc aga ccc cta gaa        812
Glu Lys Ser Gly Val Leu Lys Leu Gln Leu Asp Cys Arg Pro Leu Glu           
                185                 190                 195               

ggc aac agc aca gtt act gga caa ccg agg cgg ctc ttg gac aca gca        860
Gly Asn Ser Thr Val Thr Gly Gln Pro Arg Arg Leu Leu Asp Thr Ala           
            200                 205                 210                   

gga cac cag cag ccc ttc cta gag ctt aag atc cga gcc aat gag cct        908
Gly His Gln Gln Pro Phe Leu Glu Leu Lys Ile Arg Ala Asn Glu Pro           
        215                 220                 225                       

gga gca ggc cgg gcc agg agg agg acc ccc acc tgt gag cct gcg acc        956
Gly Ala Gly Arg Ala Arg Arg Arg Thr Pro Thr Cys Glu Pro Ala Thr           
    230                 235                 240                           

ccc tta tgt tgc agg cga gac cat tac gta gac ttc cag gaa ctg gga       1004
Pro Leu Cys Cys Arg Arg Asp His Tyr Val Asp Phe Gln Glu Leu Gly           
245                 250                 255                 260           

tgg cgg gac tgg ata ctg cag ccc gag ggg tac cag ctg aat tac tgc       1052
Trp Arg Asp Trp Ile Leu Gln Pro Glu Gly Tyr Gln Leu Asn Tyr Cys           
                265                 270                 275               

agt ggg cag tgc cct ccc cac ctg gct ggc agc cca ggc att gct gcc       1100
Ser Gly Gln Cys Pro Pro His Leu Ala Gly Ser Pro Gly Ile Ala Ala           
            280                 285                 290                   

tct ttc cat tct gcc gtc ttc agc ctc ctc aaa gcc aac aat cct tgg       1148
Ser Phe His Ser Ala Val Phe Ser Leu Leu Lys Ala Asn Asn Pro Trp           
        295                 300                 305                       

cct gcc agt acc tcc tgt tgt gtc cct act gcc cga agg ccc ctc tct       1196
Pro Ala Ser Thr Ser Cys Cys Val Pro Thr Ala Arg Arg Pro Leu Ser           
    310                 315                 320                           

ctc ctc tac ctg gat cat aat ggc aat gtg gtc aag acg gat gtg cca       1244
Leu Leu Tyr Leu Asp His Asn Gly Asn Val Val Lys Thr Asp Val Pro           
325                 330                 335                 340           

gat atg gtg gtg gag gcc tgt ggc tgc agc tag caagaggacc tggggctttg     1297
Asp Met Val Val Glu Ala Cys Gly Cys Ser                                   
                345                 350                                   

gagtgaagag accaagatga agtttcccag gcacagggca tctgtgactg gaggcatcag     1357

attcctgatc cacaccccaa cccaacaacc acctggcaat atgactcact tgacccctat     1417

gggacccaaa tgggcacttt cttgtctgag actctggctt attccaggtt ggctgatgtg     1477

ttgggagatg ggtaaagcgt ttcttctaaa ggggtctacc cagaaagcat gatttcctgc     1537

cctaagtcct gtgagaagat gtcagggact agggagggag ggagggaagg cagagaaaaa     1597

ttacttagcc tctcccaaga tgagaaagtc ctcaagtgag gggaggagga agcagataga     1657

tggtccagca ggcttgaagc agggtaagca ggctggccca gggtaagggc tgttgaggta     1717

ccttaaggga aggtcaagag ggagatgggc aaggcgctga gggaggatgc ttaggggacc     1777

cccagaaaca ggagtcagga aaatgaggca ctaagcctaa gaagttccct ggtttttccc     1837

aggggacagg acccactggg agacaagcat ttatactttc tttcttcttt tttatttttt     1897

tgagatcgag tctcgctctg tcaccaggct ggagtgcagt gacacgatct tggctcactg     1957

caacctccgt ctcctgggtt caagtgattc ttctgcctca gcctcccgag cagctgggat     2017

tacaggcgcc cactaatttt tgtattctta gtagaaacga ggtttcaaca tgttggccag     2077

gatggtctca atctcttgac ctcttgatcc acccgacttg gcctcccgaa gtgatgagat     2137

tataggcgtg agccaccgcg cctggcttat actttcttaa taaaaaggag aaagaaaatc     2197

aacaaatgtg agtcataaag aagggttagg gtgatggtcc agagcaacag ttcttcaagt     2257

gtactctgta ggcttctggg aggtcccttt tcaggggtgt ccacaaagtc aaagctattt     2317

tcataataat actaacatgt tatttgcctt ttgaattctc attatcttaa aattgtattg     2377

tggagttttc cagaggccgt gtgacatgtg attacatcat ctttctgaca tcattgttaa     2437

aaaaaaaaaa aaaaaa                                                     2453


<210>  378
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  378

Met Arg Leu Pro Asp Val Gln Leu Trp Leu Val Leu Leu Trp Ala Leu 
1               5                   10                  15      


Val Arg Ala Gln Gly Thr Gly Ser Val Cys Pro Ser Cys Gly Gly Ser 
            20                  25                  30          


Lys Leu Ala Pro Gln Ala Glu Arg Ala Leu Val Leu Glu Leu Ala Lys 
        35                  40                  45              


Gln Gln Ile Leu Asp Gly Leu His Leu Thr Ser Arg Pro Arg Ile Thr 
    50                  55                  60                  


His Pro Pro Pro Gln Ala Ala Leu Thr Arg Ala Leu Arg Arg Leu Gln 
65                  70                  75                  80  


Pro Gly Ser Val Ala Pro Gly Asn Gly Glu Glu Val Ile Ser Phe Ala 
                85                  90                  95      


Thr Val Thr Asp Ser Thr Ser Ala Tyr Ser Ser Leu Leu Thr Phe His 
            100                 105                 110         


Leu Ser Thr Pro Arg Ser His His Leu Tyr His Ala Arg Leu Trp Leu 
        115                 120                 125             


His Val Leu Pro Thr Leu Pro Gly Thr Leu Cys Leu Arg Ile Phe Arg 
    130                 135                 140                 


Trp Gly Pro Arg Arg Arg Arg Gln Gly Ser Arg Thr Leu Leu Ala Glu 
145                 150                 155                 160 


His His Ile Thr Asn Leu Gly Trp His Thr Leu Thr Leu Pro Ser Ser 
                165                 170                 175     


Gly Leu Arg Gly Glu Lys Ser Gly Val Leu Lys Leu Gln Leu Asp Cys 
            180                 185                 190         


Arg Pro Leu Glu Gly Asn Ser Thr Val Thr Gly Gln Pro Arg Arg Leu 
        195                 200                 205             


Leu Asp Thr Ala Gly His Gln Gln Pro Phe Leu Glu Leu Lys Ile Arg 
    210                 215                 220                 


Ala Asn Glu Pro Gly Ala Gly Arg Ala Arg Arg Arg Thr Pro Thr Cys 
225                 230                 235                 240 


Glu Pro Ala Thr Pro Leu Cys Cys Arg Arg Asp His Tyr Val Asp Phe 
                245                 250                 255     


Gln Glu Leu Gly Trp Arg Asp Trp Ile Leu Gln Pro Glu Gly Tyr Gln 
            260                 265                 270         


Leu Asn Tyr Cys Ser Gly Gln Cys Pro Pro His Leu Ala Gly Ser Pro 
        275                 280                 285             


Gly Ile Ala Ala Ser Phe His Ser Ala Val Phe Ser Leu Leu Lys Ala 
    290                 295                 300                 


Asn Asn Pro Trp Pro Ala Ser Thr Ser Cys Cys Val Pro Thr Ala Arg 
305                 310                 315                 320 


Arg Pro Leu Ser Leu Leu Tyr Leu Asp His Asn Gly Asn Val Val Lys 
                325                 330                 335     


Thr Asp Val Pro Asp Met Val Val Glu Ala Cys Gly Cys Ser 
            340                 345                 350 


<210>  379
<211>  10923
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (223)..(1431)

<400>  379
attcatttcc tgagaactgc agagagccgc tgagaggctc tgcgtgtgcg tgtgcgcggg       60

tgacgccgtg tgtgtgcgag tgtgtgtgtg tgtgtgcgcg cgcgcgtgtg agagagagaa      120

agggagagag agagggggac tctgtgtgag ggaaagaaaa caatttctcc tgctctgcag      180

cttctgttca ggatcaatgt gactctaaga acaaatggat ga atg aat atc cat         234
                                               Met Asn Ile His            
                                               1                          

atg aag aga aaa aca ata aag aat atc aac acc ttt gag aac aga atg        282
Met Lys Arg Lys Thr Ile Lys Asn Ile Asn Thr Phe Glu Asn Arg Met           
5                   10                  15                  20            

tta atg ctt gat ggg atg ccg gca gtc aga gtc aaa aca gag ctt ttg        330
Leu Met Leu Asp Gly Met Pro Ala Val Arg Val Lys Thr Glu Leu Leu           
                25                  30                  35                

gaa tct gaa caa ggg tct cca aac gtc cac aac tat ccc gat atg gaa        378
Glu Ser Glu Gln Gly Ser Pro Asn Val His Asn Tyr Pro Asp Met Glu           
            40                  45                  50                    

gcc gtt ccc ctg ttg cta aat aat gtg aaa ggg gag ccc ccg gag gac        426
Ala Val Pro Leu Leu Leu Asn Asn Val Lys Gly Glu Pro Pro Glu Asp           
        55                  60                  65                        

tcg tta tct gta gat cac ttc caa aca caa act gag cca gtg gac ttg        474
Ser Leu Ser Val Asp His Phe Gln Thr Gln Thr Glu Pro Val Asp Leu           
    70                  75                  80                            

tca ata aac aaa gcc agg acg tcc cct act gcc gtt tca tcc tcc cca        522
Ser Ile Asn Lys Ala Arg Thr Ser Pro Thr Ala Val Ser Ser Ser Pro           
85                  90                  95                  100           

gtt tcc atg aca gca tct gcc tcc tca cct tct tca act tca acc tct        570
Val Ser Met Thr Ala Ser Ala Ser Ser Pro Ser Ser Thr Ser Thr Ser           
                105                 110                 115               

tca tcg tct tct agt cgt cta gcc tca tcc cca act gtt atc aca tca        618
Ser Ser Ser Ser Ser Arg Leu Ala Ser Ser Pro Thr Val Ile Thr Ser           
            120                 125                 130                   

gta tct tca gcg tca tct tcg tca aca gta tta act cca ggg ccc ctt        666
Val Ser Ser Ala Ser Ser Ser Ser Thr Val Leu Thr Pro Gly Pro Leu           
        135                 140                 145                       

gtg gcc tct gca tct ggt gtt gga ggc cag cag ttt ttg cac att atc        714
Val Ala Ser Ala Ser Gly Val Gly Gly Gln Gln Phe Leu His Ile Ile           
    150                 155                 160                           

cat ccc gta ccg cct tca agt ccc atg aat tta cag tct aac aaa ctg        762
His Pro Val Pro Pro Ser Ser Pro Met Asn Leu Gln Ser Asn Lys Leu           
165                 170                 175                 180           

agt cat gtt cac cgc atc ccc gtg gtg gta cag tcg gtg cct gtt gtc        810
Ser His Val His Arg Ile Pro Val Val Val Gln Ser Val Pro Val Val           
                185                 190                 195               

tac aca gct gta agg tca cct gga aat gtg aac aac act att gtc gtg        858
Tyr Thr Ala Val Arg Ser Pro Gly Asn Val Asn Asn Thr Ile Val Val           
            200                 205                 210                   

ccg ctt ttg gag gat ggg aga ggc cat ggc aaa gca caa atg gac ccc        906
Pro Leu Leu Glu Asp Gly Arg Gly His Gly Lys Ala Gln Met Asp Pro           
        215                 220                 225                       

cga ggc cta tct ccc aga caa agt aaa agt gac agt gat gat gat gac        954
Arg Gly Leu Ser Pro Arg Gln Ser Lys Ser Asp Ser Asp Asp Asp Asp           
    230                 235                 240                           

ctg cca aat gtg acc tta gat agc gtt aat gaa act gga tct acg gcc       1002
Leu Pro Asn Val Thr Leu Asp Ser Val Asn Glu Thr Gly Ser Thr Ala           
245                 250                 255                 260           

ctt tcc ata gcc aga gca gta caa gag gta cat ccg tcc cca gta tca       1050
Leu Ser Ile Ala Arg Ala Val Gln Glu Val His Pro Ser Pro Val Ser           
                265                 270                 275               

agg gtc cgg ggc aat cga atg aat aat caa aag ttt cct tgt tca att       1098
Arg Val Arg Gly Asn Arg Met Asn Asn Gln Lys Phe Pro Cys Ser Ile           
            280                 285                 290                   

tca cca ttt agt att gag agc aca aga cgc cag aga cgg tct gaa tcc       1146
Ser Pro Phe Ser Ile Glu Ser Thr Arg Arg Gln Arg Arg Ser Glu Ser           
        295                 300                 305                       

cca gac tcc aga aaa cgg cgt atc cac aga tgt gat ttt gag gga tgc       1194
Pro Asp Ser Arg Lys Arg Arg Ile His Arg Cys Asp Phe Glu Gly Cys           
    310                 315                 320                           

aac aaa gtg tac aca aaa agt tct cac ctg aag gct cac cgg agg aca       1242
Asn Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala His Arg Arg Thr           
325                 330                 335                 340           

cat aca gga gag aaa cct tac aag tgt acc tgg gaa ggc tgc acc tgg       1290
His Thr Gly Glu Lys Pro Tyr Lys Cys Thr Trp Glu Gly Cys Thr Trp           
                345                 350                 355               

aag ttc gct cgt tca gat gaa ctg acg agg cat tac cgc aaa cat acg       1338
Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg Lys His Thr           
            360                 365                 370                   

gga gtg aag cca ttc aag tgc gcg gac tgt gat cgc agc ttt tcc cgg       1386
Gly Val Lys Pro Phe Lys Cys Ala Asp Cys Asp Arg Ser Phe Ser Arg           
        375                 380                 385                       

tca gat cat ttg gcc ctg cac cgc cgg agg cat atg ttg gtg tga           1431
Ser Asp His Leu Ala Leu His Arg Arg Arg His Met Leu Val                   
    390                 395                 400                           

ggaatgctac ctgtccagct gagcgtaaga gctggatctc ttagcggcac ccaattcagc     1491

agggctgaat ccccttcaca gtgttaacac aaaagggcat caccatccca cgatgtctga     1551

aaccagagca ggaaaaagaa ggcacacttc ttttggtctg aaggtaaccc ccatcatgac     1611

tagacgagaa ccgtctttac ccgggcctgg gagctcagtg acataaatgc tgaagagaca     1671

ggcattgttt tccgtgctgt gtcctctgcc atttaaagat gtttgtagct tgtacatttt     1731

ctgagctgtc agacattttg ttattgatac cttaaaggtc acctaccaca aattgatggc     1791

tagagcaaga ccttttaaat ttggatgaat ctcccatcat cccatccctt aacccctttt     1851

tacagaaatt ttagttacaa tctgagtaag ctagaacaca catccaatct gttaccagca     1911

agcagcatga aagtagaaac gaagaagcag atggagaggt cccattacct gcaaagaaag     1971

ggcactcagg cagccctttg caatcgcgat ggcagccact agatatcact ctcaacttgt     2031

cattctgcca tgccctgaag aaaaccaaca ttgaatcttt catttgtttg tcgttgattg     2091

tttttgtttt gtttcgattc tgttttgttc atctgttcga gcagaggggc agttgaagtc     2151

tcgtcctggt ctctgccctg gcatggactg gcacagaggt gttctgtagt tgaataggaa     2211

gagcctgtct aaaaaactac tgccccactt caaattgcag tgttctgtca cctaggcatc     2271

atctcttcct gcccctagta tttgattaca aggaaccagg ggaaaaaaac tttcttagac     2331

acactggcac caaggtaaga ggtggggctg cccaggcaaa gtcagtgaac atgaaaactc     2391

agacaaagca gagatggaaa taatgcgcct cttgaggaga aaagcaataa tgaataaaag     2451

gactttccta caataacttc actgaggact cacgttacca attttcatac ttactaaagg     2511

gattgtaaaa aacaccccag cattttaggt gtcttggttc catttacagc actgaggtaa     2571

tctttctgct gtttgttgtc ctgcttggtt gagtaccaca attaaagatt atgctcccct     2631

tttcttgttt gaaaacagtt atttggtgac tagaaaggca agggaggcat agccgggaat     2691

taactcttcg gttaatgggt cagttctcct tggaactgaa tcagtggaaa gagaatgctt     2751

cccatagaaa gcccgacatg gtgctagttt cctctcttgg agagccaagg ataagtgact     2811

ctccaatagg ttcttctata ccgatttcat tttctaaact gtatcaggac ccaggtgtcc     2871

tgcattggca tctgcaggga tattgaaccc actcatcctg tgcagaggat gagaggaagg     2931

tgttagttcc atcagcccca taaaattatg aacctttttg caactaggaa catatacagt     2991

aaacaagcaa tacatcacca acgagcattc tttcagaaaa attaccatat ttttgtcccc     3051

accacaagct gggttttttt ccagctttct gtggctgagg ggctggtgag attttttgtt     3111

gttattgttg ttgttgctag aattttttat agcttagata taaaaggtct ccaacaaaga     3171

cctttgcaat atattttaat tacaaacact tgattttggg aattgcacat attaacctca     3231

caatattact agctcatttt taaatgtctg gacattctga aataatttcc ggttacagaa     3291

ttaccctttt taggatcatc ttctaattca gataatctta ttctgatgaa gcgagaacta     3351

tgaacgttga aacaaggaca atttgtgttg gatggtattc aaaaggaatt ttttaaaaca     3411

ttaagcaaca gtgtaatgat tttcaggtca aattatggct tcacaaatat gtgctctata     3471

ttgtctgcca ggtctcaaaa attcatcaag caatttccct ccaacaaggg ctgcagttct     3531

agtgataaat agcatcttta gctgcacagt ctactactca tcaaccagtg ggtttttttt     3591

agcacctgga aagttttttt gtactatatg caactcctac ttcacattgc ctgtgaccat     3651

tcagaataga aaaaggtctg ttgatgcatg ccagtgctgg ttactagtca gtgacagaga     3711

acacagagag ggacaaacac agccatgaac cccctggcac tagtaccagc acctagttgg     3771

caagtagtgg gtgcatctct caagtgaagt gtagatttgt atttagtcct gcttgctctc     3831

ataaaaagag ccagttcttt tctctgctga aagatgtctt gagagtatta caggtagact     3891

tggtttttag aattcataaa actgacaggc aggggaatct tcctgagtga cagcttggtt     3951

taaatttagc acagaactag atgagttgca cttttctaat aacataggat ggatttgggg     4011

aagggaacat tttccctcat cctctgaaag tggaaaccag actgagatgg taagttaact     4071

gataaaacct gtcagcattc catcattttc cccttttgac gtatcagtac ttctaagaag     4131

ggatctaagc acaattaagt gaattgagtc cctggtctag cctcaggaac tgaaacttct     4191

ttggggcttg tcttgagacg tggcaaattc tccttggtga gttttctaaa agtatttccc     4251

catggaaagg agaaagtggt ttgggacaga aagaaatgga atgtcttcag tcatggaaga     4311

gcctccattt catctcatgt ccatttctag cctctttcaa aaagcacagt gcatcatgag     4371

caacagaaaa gcagtagaat cctaaaggac ataacagttg ttccgtaact agaagcattc     4431

tttgatttta aatttgaagc tgttcagttt gcagctgggg atatgtgcat ggttgggaac     4491

ttatacacat agagccatta actacttaag cagctgcagt agacctgatt ttctgtttgc     4551

agtatagaga ttgatttcaa gggagttaca ttatttgaaa agttatgact ttcagccttt     4611

gaggttttaa gaatcccttt tcatggtctg atcttaagtt gtttgaaaaa agattcacgc     4671

ttctgcatcc acctctgccc tcattctgtc aattgtgtgt ggactctgag aagcctgctt     4731

gataacttgt cttaagttct attaaggcag ttagactgag atttctaatg acttcaccat     4791

aaagattata cttctgcctg gcgtcgtttc tataaaacac tataggacat ttgttttcaa     4851

aagcagttga gtaacagcaa cataaaccac attttttaaa aaaatgagca cttttcattc     4911

acttgaaagc ttaagtggga aaaaggaaga tgattgtcag gggaaaaact tacaaaatgc     4971

tacagtgttt acaaatgcca gttccaggtg attagaaagg ccgttttcat tatggttcag     5031

atttggaata gcttatgcaa agattgtgtt catttttata caattctttt taactttaaa     5091

ttgccatctg tgttttaaac ataattctgc actttggaat cagttcatta gaatgataac     5151

atttatatgg ataaagatgc agtattcctt attctgtact tgatttatta tacttaccaa     5211

agctgcaact gaataaatct ggtgaggtga ggccttcaaa atgtattaat acgcctttgt     5271

tatgttgtta tgactgctta gaaatgtagc catgatgttg ttctaaagat gtcttaacat     5331

ttatagtgag gattgacaga aattaagcag tgttaagaat accagcatcc atgttacagt     5391

ctgcgtataa gggactgaat gtgaggtaac tcttatgaat cataataggc ccagaaagcc     5451

ttaatattca tagttcataa tccagtctca gattttgctc ttcaatgttg cctgtaaact     5511

tagcaggtaa atgtattcta gtataaaaca tcattgacca aatctcttcc tttagttttt     5571

ctgaggtagt gcatcccatt aaaaaagtct cttcaattag atttggcttt agtttagaaa     5631

ggggtttggt aagtcatgtc ttccatatga catttctact catccccaca ctgccttcca     5691

cttaacctgt acagacagcc ccaacacatg cacatgtgtg tacacaactg tatatgcagc     5751

agccagtggg ctaacaaata tcagcaaaga acttttttaa aaagaatttg taataatccg     5811

tgctgtctag aaatgtgagt tacttacctt attaggaaac cggcttataa tactatatat     5871

gactctgcct gcattttata gttaagaaat gtacataaaa attgctatat tttcacagtt     5931

tcattataat gtctgtttag taacccatgt ccactgatac tttaaatatg ctaattactg     5991

agcaattgca atagaaatcc agattttcat aagaaaatga aatagaagga tactgcatct     6051

ttaaaaaata gagtgaagat attttactgt attcgtaaca tatgtgatag tggaaaaagt     6111

attttcaaac tcacaaattt tacagaggtt gtaaatagtt tgatgaagta tgttgggaaa     6171

gagagcttct agttttcatc acaataaaaa gaaaaaactt gttcagatat gccttgtata     6231

tcttacacac aatgagtgaa attgccatgg gaactctgtc caactttgtc agagcatgct     6291

cttcgtgttc tgttcaaaat agagtggcca cttgtcatgg tttagccagg atggtttaaa     6351

atataatgaa gtcattttaa gttgcagaca actgattcca aactagtaat gtcttttcct     6411

gaaaagggca aaacagctgc acaggatttt gcttgtacta aagaggagca tcttacaatt     6471

gttctctttt ctcagttatc tccctcctca acagagtgtg aacaaccata caggtgttta     6531

ttcttgtttt attccaggga gactgctttt aggtataact acatgttgac aagattaagt     6591

gctgtggata tggccacgtg ttaaaggaat ctatactcgc aataggaata agctaatgcc     6651

cattttcaga aataaattaa atgctgaaag tgcctgtcag taaaccttat gaccaatgag     6711

atattcctat acttttacac agcaataatt cttaataaga ctgggttttt tcctgcacat     6771

gtgaacacac acacacatac acacagagag agtaaataca tacacatagt aaatcaaatc     6831

tgttcacatg cccacaaaaa acgcttttat agctttcaaa tatacctaat cttgtttaca     6891

ttaacatttc ttaatttgat ctttctaact tgcagaacgt taagaacaca aatctgaaca     6951

ttaagtttat cttcagtgaa cactattgca tatggtaatt ataatttcca gataaaaagt     7011

tgactgtcat ttgccccaaa cttatgaaac agtatgtatg attcaaaaag ttttgctcag     7071

ttaaaaacac caatttattt ggcgcaaaag actgaaggat atttgtttgc ttgttcattt     7131

tatccactca tatcaaacgc acaaattcat ctttacattt cttcattccc ctttccccta     7191

atatttccta ttatcatctt aagaatcatt ttggaatgaa tattgacaga atcatttctc     7251

cccaaaaagt ctgttgaagt accactgaca cttagtaagc ctagccttta accatctttg     7311

cagttagtcc taaaaattac cagatgcaca ttcagaagct cacaggtttt ttcctgtaat     7371

tactgtactg ctaaaagtgg agtcatggat agaaatatac aatgagacta tatgaataga     7431

catgaaccct ggaaattctc caaccctgcc atctcagagc acaaattcac ccaaacaagc     7491

tactgaggct atcagtaaaa ttatactcat ggagagtcac acatcgggta agggcaattt     7551

taaaagtagg actgtgatta aacattcagg ctttagactt ccatgatgga ctcagaccac     7611

aggcctcaaa aaaacatcca ctgttttctc ctcccaatgt tagaaagaag aaaagggaga     7671

cggaaatgta ccaggataag ggggtaaaat aaccaattaa gtgtcaaagg aaagctgctg     7731

ggttccttaa tctcactgaa gtcaagtctt ctgactgggc ttcttaccat gtgttgtctg     7791

aaaaaactaa agtaccttga aaggttacac attcagcaaa ccatgaagat aatagctatt     7851

ctttattaaa cactgtgtgc caagcaatag actaggcaat ttttagatac gttacctgca     7911

acctgtacaa catttctaca ctttatggat gggaaacgga gacatgggaa gtgtggctga     7971

gttgttcatg gatgtagaaa tagtaaacgg cagagtagga aagtgaaacc gcctatctct     8031

gacctggagg tctgcctgta tctttcccac tccaccacac tgcacgtggg tgtcccgaaa     8091

ccaccttccc agattcctga ctctcagtaa ttttattatg gacaacatgc atgagtagtc     8151

atcatatttt tcaagtgaaa tatcgggaca tgatataaca catgacttaa caatggtact     8211

gaatatttga aatcaggcct ttcccggaaa atcatgcatg aaggatcatt ataaacaaac     8271

aatagcaacc agttgtctcc ccgaacttgt cacttttctc ataaatgtct ggcctggagc     8331

tccaaaatca tccaaatact tagtagcatt ttagcctgag tacactttct cagttcctca     8391

actctttgta tacctttcca ccaatataga cattctagaa tctgcttcag atgcatttga     8451

aattttcacc cccatggaac tagtgattaa tatcagagcc cactcttgca gttggtaatg     8511

gggtggcaat caaacgttca gatgatgata aaggagagat aatggataat tctttttcag     8571

agttctcact taacagctct gttgtggaat gttttaaata gtcttataaa taatttgttt     8631

atagtattgt tgttagttta attgaatttt atgtaagaag ctgtccaaca tcagagaaat     8691

gaaattcctc ccactttctg tgtagaacaa ggtctctgac agtattgatt catggaagta     8751

ctaatggact tagaaaacat taagagaatg tcatttctca tagtgtttct gtttctgaaa     8811

atgaatctcc tgaattatta tctttctccc tgttacttgg ctggggaaag agatagaagc     8871

tgtataaaca aattctcttc catgctcaaa gcaagtgttc catgtgcaca acctgctgca     8931

gactggggcc cttctcagtt aattgggttt cacaagcaat aatttctcca caacaaaaac     8991

cacaacttga agtgagttga aaagagatca atagtggaaa cagtcgcctc agtacttttt     9051

ctttctggat ttcatctcta gaaatttgaa gtgtttgaga cagagtccac cctttgtgca     9111

aggcgagaac caatgaatgg actccttgtg tgaattattg catcttcttc caaagcaggt     9171

tcatcaagac tttcacagag attcattttt gttgagaagt aagggttaat aggaggatag     9231

aatttggatc caaatctagt gataaaagtg tccaagcaat caaaaagtaa gatattttag     9291

ggacatacca acatcttccc tttctgctaa tttcatgctc caaagatatg gcaaaaaaaa     9351

aaatcataaa aagtgctttt gccctacttg tgttctagtt ttcccatggc agaattttgt     9411

aattacatcc agaatatagt gtatattttg ttcctcaaac tttattacat tggatggata     9471

ttgttgaact ggggcactgg tgcctatatt caaggctctt tcctatcaac gtgtctgtcc     9531

acgatttgtt gtgtttaaag cttcattttg aaaaatcact gtccccctgt ggggtagtga     9591

ctgtattgtt ttgttcatgt ctatgtggga cacattgcat cacatggcaa accaactctc     9651

tgtggatgtg agataagtac ttataaaacc agcttgaaaa catcgtctta tgtattatgt     9711

catcctgcat cataatgcaa ttatgtgtat cataacatgc tcatttaaaa aaagagaaac     9771

cagcaaattc atgtttgtcc atagaagaat gtactcagaa ctttgtgttg tgaaacgatg     9831

agaacagacc acctttaaga tacccacctg ccacttaaaa tgacttagtt ataattagta     9891

gtagtctaga cgttgttctt ggtgtgtggg ggtcaattct aacgtcatgt tcttttgaat     9951

aaatctctca gtcatatttg aaaaaaaaat acatgggaat aaagaaaaat atcatctttg    10011

gccaaatcaa gcaggcatct tttttctttt ccttgacgtt tagctcatta tacgtggtga    10071

ttggatcacg agatctgtcc gtgtgaaaat acagaaacat cctttagttt acaaaacagt    10131

tattctaggc ttgaagcctc tgaacagcaa attgaataga tgggctgcat ctgatttgct    10191

ttatggatgt aattttacaa aacactcttg ggtctctgac cccagggagt taagagtgcc    10251

cagaggaggt cctacacatt aaaggataaa gccccccagt gatgctggca agcaaatgtg    10311

ttgagttctt aaatcttcat ttggttttct gttcaggatt ttaattgcaa atgaatttat    10371

ttctccagtt tatctaaaga cctaatttcc caatagtttc ctctgcattt atatactctg    10431

tagtgtttag gcaaccctgt tataagttta ttaatattat gtaagtgttg ttcttgtatt    10491

tatgtatagt gtatgtattg taaatatact cagagctttt ttccttttac tgtaaaatgg    10551

tgattttttt gccctatgat aatgtaaagg gagaccctcc taatgagatt ctctcagagg    10611

atgattattc cagtctattc tcagagattt aaatgaacaa gtgttattgt ttttaatggt    10671

gtctcagaca tattctgttg gtgcattgct tttctgtatt caactttcct atgaattgag    10731

ctgtgaactg aaatagagtt taaaccttta actgtatgca tttgtataat tatctgaatg    10791

aaggcatgaa ggttaaataa agcattttgt atggaacaaa actccctaac tgactcagac    10851

actttggaaa tcatagttat taaccattct aattaaacct ttgttatgaa aagttttaaa    10911

aaaaaaaaaa aa                                                        10923


<210>  380
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  380

Met Asn Ile His Met Lys Arg Lys Thr Ile Lys Asn Ile Asn Thr Phe 
1               5                   10                  15      


Glu Asn Arg Met Leu Met Leu Asp Gly Met Pro Ala Val Arg Val Lys 
            20                  25                  30          


Thr Glu Leu Leu Glu Ser Glu Gln Gly Ser Pro Asn Val His Asn Tyr 
        35                  40                  45              


Pro Asp Met Glu Ala Val Pro Leu Leu Leu Asn Asn Val Lys Gly Glu 
    50                  55                  60                  


Pro Pro Glu Asp Ser Leu Ser Val Asp His Phe Gln Thr Gln Thr Glu 
65                  70                  75                  80  


Pro Val Asp Leu Ser Ile Asn Lys Ala Arg Thr Ser Pro Thr Ala Val 
                85                  90                  95      


Ser Ser Ser Pro Val Ser Met Thr Ala Ser Ala Ser Ser Pro Ser Ser 
            100                 105                 110         


Thr Ser Thr Ser Ser Ser Ser Ser Ser Arg Leu Ala Ser Ser Pro Thr 
        115                 120                 125             


Val Ile Thr Ser Val Ser Ser Ala Ser Ser Ser Ser Thr Val Leu Thr 
    130                 135                 140                 


Pro Gly Pro Leu Val Ala Ser Ala Ser Gly Val Gly Gly Gln Gln Phe 
145                 150                 155                 160 


Leu His Ile Ile His Pro Val Pro Pro Ser Ser Pro Met Asn Leu Gln 
                165                 170                 175     


Ser Asn Lys Leu Ser His Val His Arg Ile Pro Val Val Val Gln Ser 
            180                 185                 190         


Val Pro Val Val Tyr Thr Ala Val Arg Ser Pro Gly Asn Val Asn Asn 
        195                 200                 205             


Thr Ile Val Val Pro Leu Leu Glu Asp Gly Arg Gly His Gly Lys Ala 
    210                 215                 220                 


Gln Met Asp Pro Arg Gly Leu Ser Pro Arg Gln Ser Lys Ser Asp Ser 
225                 230                 235                 240 


Asp Asp Asp Asp Leu Pro Asn Val Thr Leu Asp Ser Val Asn Glu Thr 
                245                 250                 255     


Gly Ser Thr Ala Leu Ser Ile Ala Arg Ala Val Gln Glu Val His Pro 
            260                 265                 270         


Ser Pro Val Ser Arg Val Arg Gly Asn Arg Met Asn Asn Gln Lys Phe 
        275                 280                 285             


Pro Cys Ser Ile Ser Pro Phe Ser Ile Glu Ser Thr Arg Arg Gln Arg 
    290                 295                 300                 


Arg Ser Glu Ser Pro Asp Ser Arg Lys Arg Arg Ile His Arg Cys Asp 
305                 310                 315                 320 


Phe Glu Gly Cys Asn Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala 
                325                 330                 335     


His Arg Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Thr Trp Glu 
            340                 345                 350         


Gly Cys Thr Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr 
        355                 360                 365             


Arg Lys His Thr Gly Val Lys Pro Phe Lys Cys Ala Asp Cys Asp Arg 
    370                 375                 380                 


Ser Phe Ser Arg Ser Asp His Leu Ala Leu His Arg Arg Arg His Met 
385                 390                 395                 400 


Leu Val 
        


<210>  381
<211>  2786
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (273)..(1376)

<400>  381
agtgttctta gaggtagcca cacctcagca agggctttct aacttggaac agcaaagttc       60

aaatgaacga atagacacaa actgtgaaag agtcctgaac ccattacaag gtgaatcttt      120

acagcacaat tgccttctga agctacttga aacagggcat gggacttaaa ggagaaaaaa      180

aaggaaatgg accatctctt ctaacacctg gaatgtgatc caagcctgga gacaaattga      240

tggtttgcag ctagaagaca gtaaatctag ca atg gag ccc ata tat gag gag        293
                                    Met Glu Pro Ile Tyr Glu Glu           
                                    1               5                     

tac cta gca aat cat gga aca ata gta aaa cca tat tac tgg cta agc        341
Tyr Leu Ala Asn His Gly Thr Ile Val Lys Pro Tyr Tyr Trp Leu Ser           
        10                  15                  20                        

ttc tct ctc gat tgc tct aat tgt cct tac cat att cga aca ggt gaa        389
Phe Ser Leu Asp Cys Ser Asn Cys Pro Tyr His Ile Arg Thr Gly Glu           
    25                  30                  35                            

gaa gca aga gtt tcc ctc aca gaa ttt tgt cag att ttt gga ttc cct        437
Glu Ala Arg Val Ser Leu Thr Glu Phe Cys Gln Ile Phe Gly Phe Pro           
40                  45                  50                  55            

tat ggg aca aca ttt cct caa aca aaa cac ctc aca ttt tat gaa cta        485
Tyr Gly Thr Thr Phe Pro Gln Thr Lys His Leu Thr Phe Tyr Glu Leu           
                60                  65                  70                

aaa act tct tct ggt agc ctg gtg caa aag ggc cat gct agc agt tgc        533
Lys Thr Ser Ser Gly Ser Leu Val Gln Lys Gly His Ala Ser Ser Cys           
            75                  80                  85                    

act ggg aat tat atc cat cca gaa tca atg ctc ttt gaa atg aat ggt        581
Thr Gly Asn Tyr Ile His Pro Glu Ser Met Leu Phe Glu Met Asn Gly           
        90                  95                  100                       

tat ctt gac tca gcc ata tac aat aat gac agc atc agg cat atc att        629
Tyr Leu Asp Ser Ala Ile Tyr Asn Asn Asp Ser Ile Arg His Ile Ile           
    105                 110                 115                           

ctg tat tcc aac aac tcc cct tgt aat gaa gct aac cac tgc tgc atc        677
Leu Tyr Ser Asn Asn Ser Pro Cys Asn Glu Ala Asn His Cys Cys Ile           
120                 125                 130                 135           

agc aaa atg tat aat ttc ctg att acg tat cca ggc atc act ctt agt        725
Ser Lys Met Tyr Asn Phe Leu Ile Thr Tyr Pro Gly Ile Thr Leu Ser           
                140                 145                 150               

att tat ttt tct cag ctc tat cat act gag atg gac ttt cct gcc tca        773
Ile Tyr Phe Ser Gln Leu Tyr His Thr Glu Met Asp Phe Pro Ala Ser           
            155                 160                 165                   

gca tgg aac cgc gaa gct ctc cgg agc ctg gcc agc tta tgg ccg cgg        821
Ala Trp Asn Arg Glu Ala Leu Arg Ser Leu Ala Ser Leu Trp Pro Arg           
        170                 175                 180                       

gtt gtt ttg agt cca ata agt ggt ggg atc tgg cat tct gtt ctc cac        869
Val Val Leu Ser Pro Ile Ser Gly Gly Ile Trp His Ser Val Leu His           
    185                 190                 195                           

agc ttt ata agt ggt gtc tca gga tca cat gtt ttt cag ccc att tta        917
Ser Phe Ile Ser Gly Val Ser Gly Ser His Val Phe Gln Pro Ile Leu           
200                 205                 210                 215           

act ggg aga gca ctg gct gac agg cac aac gca tat gaa atc aat gcc        965
Thr Gly Arg Ala Leu Ala Asp Arg His Asn Ala Tyr Glu Ile Asn Ala           
                220                 225                 230               

ata aca ggc gta aaa cct tac ttc act gat gtt ctt ctc cag aca aaa       1013
Ile Thr Gly Val Lys Pro Tyr Phe Thr Asp Val Leu Leu Gln Thr Lys           
            235                 240                 245                   

agg aat cca aac aca aaa gct cag gag gct tta gag agc tac ccc tta       1061
Arg Asn Pro Asn Thr Lys Ala Gln Glu Ala Leu Glu Ser Tyr Pro Leu           
        250                 255                 260                       

aac aat gcc ttt cct gga cag ttt ttt caa atg ccg agt gga caa ctc       1109
Asn Asn Ala Phe Pro Gly Gln Phe Phe Gln Met Pro Ser Gly Gln Leu           
    265                 270                 275                           

caa ccc aac cta cct cca gac ctc agg gct cct gtt gtt ttt gtg cta       1157
Gln Pro Asn Leu Pro Pro Asp Leu Arg Ala Pro Val Val Phe Val Leu           
280                 285                 290                 295           

gtg cct ctc agg gac tta cca cca atg cat atg ggc caa aac cca aat       1205
Val Pro Leu Arg Asp Leu Pro Pro Met His Met Gly Gln Asn Pro Asn           
                300                 305                 310               

aaa ccc agg aat atc gta agg cac tta aat atg cct caa atg tca ttc       1253
Lys Pro Arg Asn Ile Val Arg His Leu Asn Met Pro Gln Met Ser Phe           
            315                 320                 325                   

cag gaa acc aag gac ctt gga agg ctt ccc act gga agg tca gtg gag       1301
Gln Glu Thr Lys Asp Leu Gly Arg Leu Pro Thr Gly Arg Ser Val Glu           
        330                 335                 340                       

ata gtg gaa atc aca gaa cag ttt gca agt agc aag gag gca gat gaa       1349
Ile Val Glu Ile Thr Glu Gln Phe Ala Ser Ser Lys Glu Ala Asp Glu           
    345                 350                 355                           

aag aag aag aag aaa ggg aag aaa taa aatctacatt cctacagcat             1396
Lys Lys Lys Lys Lys Gly Lys Lys                                           
360                 365                                                   

gaaaccaatt accaagggac ttattagata ggcaataaaa atctggaaac tttctctctc     1456

agggctgagc caagatggag ataaactgat gcactaaaag caaaccttga attatttacc     1516

atatcaacta ttataaagtt acactatttt aaacataatc caaaatgttt ccataagcaa     1576

cttgatctct ctcctttatt ttgaaagtgg cagtatcaaa atggaaccat tagcagcttg     1636

ctaatatttt gatgcagaaa aggaatctca ttattctatt ttactcacat catctttcca     1696

ctacaaaagc ccatggacaa aatagctacc taaatttgtt tcggtaaaaa atttactgta     1756

aaattgaaaa acagcctgaa gctactgaca ttaagtgctg tttgcaggag caaaccagtg     1816

attttctatt aattgttaat catggacaga agattttagg cagctcattt ttttctaaag     1876

tgattcaaaa tagttttgtg tgggaaaaag ctcttctgct gattacatat agctataaag     1936

attaaaacct agccacctgc tcagtttgat cttccccagc tcagacctct cccttctgag     1996

cagatgatag aggtaagatg atacatgaga acctccaatg gctcctgtca tcacatactg     2056

tataaaatcc aagttcctct tactggcttt caaggatcct cctttaactt cctgttgcct     2116

tgtctcatca gcaagatcat aagtacctac aggtcaagca ctgtctctcc cttctcttta     2176

gcttttccct taggatctag cacattaccc agcaaaatgt gagtagcaag gctgaaatga     2236

catctcaata acttcaccaa tgattgtaac tcagcatccc ttctccatcc cagctgaaag     2296

cctgcttcac catcctgcaa gagatgtttt ttctttttgt tagcatccat tcccctttct     2356

aatgcagctc ccaatgcata atgtgtgttt tacttccctc tttctgactc catcctcgtc     2416

accagtgaat atttgtacct tctcttaaaa tcttcaaaac acacttctag gaagtgctcc     2476

ttgattaatc ctctaagcac ttaaatgaaa gcactttgct tatgcttatt tcacatttgc     2536

tgccacttgc ctctttgaaa tatgtaaaga tacattacaa gaaaaatgta cattttctcg     2596

taacttgcta ttaatttttt tctttatata tatatataaa gtaatcctaa gctaataaaa     2656

gagtttgcca tgacattaaa acatttaata ctccataagg gaggaggaga aagaaaaaca     2716

tattttagga atagcaatta gtattgtggt taaaataaac atgaataaaa attttaaaac     2776

aaaaaaaaaa                                                            2786


<210>  382
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  382

Met Glu Pro Ile Tyr Glu Glu Tyr Leu Ala Asn His Gly Thr Ile Val 
1               5                   10                  15      


Lys Pro Tyr Tyr Trp Leu Ser Phe Ser Leu Asp Cys Ser Asn Cys Pro 
            20                  25                  30          


Tyr His Ile Arg Thr Gly Glu Glu Ala Arg Val Ser Leu Thr Glu Phe 
        35                  40                  45              


Cys Gln Ile Phe Gly Phe Pro Tyr Gly Thr Thr Phe Pro Gln Thr Lys 
    50                  55                  60                  


His Leu Thr Phe Tyr Glu Leu Lys Thr Ser Ser Gly Ser Leu Val Gln 
65                  70                  75                  80  


Lys Gly His Ala Ser Ser Cys Thr Gly Asn Tyr Ile His Pro Glu Ser 
                85                  90                  95      


Met Leu Phe Glu Met Asn Gly Tyr Leu Asp Ser Ala Ile Tyr Asn Asn 
            100                 105                 110         


Asp Ser Ile Arg His Ile Ile Leu Tyr Ser Asn Asn Ser Pro Cys Asn 
        115                 120                 125             


Glu Ala Asn His Cys Cys Ile Ser Lys Met Tyr Asn Phe Leu Ile Thr 
    130                 135                 140                 


Tyr Pro Gly Ile Thr Leu Ser Ile Tyr Phe Ser Gln Leu Tyr His Thr 
145                 150                 155                 160 


Glu Met Asp Phe Pro Ala Ser Ala Trp Asn Arg Glu Ala Leu Arg Ser 
                165                 170                 175     


Leu Ala Ser Leu Trp Pro Arg Val Val Leu Ser Pro Ile Ser Gly Gly 
            180                 185                 190         


Ile Trp His Ser Val Leu His Ser Phe Ile Ser Gly Val Ser Gly Ser 
        195                 200                 205             


His Val Phe Gln Pro Ile Leu Thr Gly Arg Ala Leu Ala Asp Arg His 
    210                 215                 220                 


Asn Ala Tyr Glu Ile Asn Ala Ile Thr Gly Val Lys Pro Tyr Phe Thr 
225                 230                 235                 240 


Asp Val Leu Leu Gln Thr Lys Arg Asn Pro Asn Thr Lys Ala Gln Glu 
                245                 250                 255     


Ala Leu Glu Ser Tyr Pro Leu Asn Asn Ala Phe Pro Gly Gln Phe Phe 
            260                 265                 270         


Gln Met Pro Ser Gly Gln Leu Gln Pro Asn Leu Pro Pro Asp Leu Arg 
        275                 280                 285             


Ala Pro Val Val Phe Val Leu Val Pro Leu Arg Asp Leu Pro Pro Met 
    290                 295                 300                 


His Met Gly Gln Asn Pro Asn Lys Pro Arg Asn Ile Val Arg His Leu 
305                 310                 315                 320 


Asn Met Pro Gln Met Ser Phe Gln Glu Thr Lys Asp Leu Gly Arg Leu 
                325                 330                 335     


Pro Thr Gly Arg Ser Val Glu Ile Val Glu Ile Thr Glu Gln Phe Ala 
            340                 345                 350         


Ser Ser Lys Glu Ala Asp Glu Lys Lys Lys Lys Lys Gly Lys Lys 
        355                 360                 365         


<210>  383
<211>  1244
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (5)..(1060)

<400>  383
gcac atg cgc gct gtc ctg gct cgg gag atg gac ggc cgc cgt gtt ttg        49
     Met Arg Ala Val Leu Ala Arg Glu Met Asp Gly Arg Arg Val Leu          
     1               5                   10                  15           

ggc cgg ttc tgg agt ggc tgg cgg cgg ggc ctg ggt gtc cgc cca gtg         97
Gly Arg Phe Trp Ser Gly Trp Arg Arg Gly Leu Gly Val Arg Pro Val           
                20                  25                  30                

ccc gag gac gca ggc ttt ggc acc gaa gcc cgg cat cag agg caa ccc        145
Pro Glu Asp Ala Gly Phe Gly Thr Glu Ala Arg His Gln Arg Gln Pro           
            35                  40                  45                    

cgc ggc tcc tgc caa cgg tcg ggg ccc ctc ggg gac cag ccc ttc gcg        193
Arg Gly Ser Cys Gln Arg Ser Gly Pro Leu Gly Asp Gln Pro Phe Ala           
        50                  55                  60                        

ggg ctg ctg cca aaa aac ctc agt cgg gag gag ctg gtt gat gcg ctg        241
Gly Leu Leu Pro Lys Asn Leu Ser Arg Glu Glu Leu Val Asp Ala Leu           
    65                  70                  75                            

cgg gca gcc gtg gtg gac cgg aaa gga cct cta gtg acg ttg aac aag        289
Arg Ala Ala Val Val Asp Arg Lys Gly Pro Leu Val Thr Leu Asn Lys           
80                  85                  90                  95            

cca cag ggt cta cca gtg aca gga aaa cca gga gag ctg acg ttg ttc        337
Pro Gln Gly Leu Pro Val Thr Gly Lys Pro Gly Glu Leu Thr Leu Phe           
                100                 105                 110               

tca gtg ctg cca gag ctg agc cag tcc cta ggg ctc agg gag cag gag        385
Ser Val Leu Pro Glu Leu Ser Gln Ser Leu Gly Leu Arg Glu Gln Glu           
            115                 120                 125                   

ctt cag gtt gtc cga gca tct ggg aaa gaa agc tct ggg ctt gta ctc        433
Leu Gln Val Val Arg Ala Ser Gly Lys Glu Ser Ser Gly Leu Val Leu           
        130                 135                 140                       

ctc tcc agc tgt ccc cag aca gct agt cgc ctc cag aag tac ttc acc        481
Leu Ser Ser Cys Pro Gln Thr Ala Ser Arg Leu Gln Lys Tyr Phe Thr           
    145                 150                 155                           

cat gca cgg aga gcc caa agg ccc aca gcc acc tac tgt gct gtc act        529
His Ala Arg Arg Ala Gln Arg Pro Thr Ala Thr Tyr Cys Ala Val Thr           
160                 165                 170                 175           

gat ggg atc cca gct gct tct gag ggg aag atc cag gct gcc ctg aaa        577
Asp Gly Ile Pro Ala Ala Ser Glu Gly Lys Ile Gln Ala Ala Leu Lys           
                180                 185                 190               

ctg gaa cac att gat ggg gtc aat ctc aca gtt cca gtg aag gcc cca        625
Leu Glu His Ile Asp Gly Val Asn Leu Thr Val Pro Val Lys Ala Pro           
            195                 200                 205                   

tcc cga aag gac atc ctg gaa ggt gtc aag aag act ctc agt cac ttt        673
Ser Arg Lys Asp Ile Leu Glu Gly Val Lys Lys Thr Leu Ser His Phe           
        210                 215                 220                       

cgt gtg gta gcc aca ggc tct ggc tgt gcc ctg gtc cag ctg cag cca        721
Arg Val Val Ala Thr Gly Ser Gly Cys Ala Leu Val Gln Leu Gln Pro           
    225                 230                 235                           

ctg aca gtg ttc tcc agt caa cta cag gtg cac atg gta cta cag ctc        769
Leu Thr Val Phe Ser Ser Gln Leu Gln Val His Met Val Leu Gln Leu           
240                 245                 250                 255           

tgc cct gtg ctt ggg gac cac atg tac tct gcc cgt gtg ggc act gtc        817
Cys Pro Val Leu Gly Asp His Met Tyr Ser Ala Arg Val Gly Thr Val           
                260                 265                 270               

ctg ggc cag cga ttt ctg ctg cca gct gag aac aac aag ccc caa aga        865
Leu Gly Gln Arg Phe Leu Leu Pro Ala Glu Asn Asn Lys Pro Gln Arg           
            275                 280                 285                   

cag gtc ctg gat gaa gcc ctc ctc aga cgc ctc cac ctg acc ccc tcc        913
Gln Val Leu Asp Glu Ala Leu Leu Arg Arg Leu His Leu Thr Pro Ser           
        290                 295                 300                       

cag gct gcc cag ctg ccc ttg cac ctc cac cta cat cgg ctc ctt ctc        961
Gln Ala Ala Gln Leu Pro Leu His Leu His Leu His Arg Leu Leu Leu           
    305                 310                 315                           

cca ggc acc agg gcc agg gac acc cct gtt gag ctc ctg gca cca ctg       1009
Pro Gly Thr Arg Ala Arg Asp Thr Pro Val Glu Leu Leu Ala Pro Leu           
320                 325                 330                 335           

ccc cct tat ttc tcc agg acc cta cag tgc ctg ggg ctc cgc tta caa       1057
Pro Pro Tyr Phe Ser Arg Thr Leu Gln Cys Leu Gly Leu Arg Leu Gln           
                340                 345                 350               

tag tcctccctct gttcctgacc ccctcacaca cactggaaag tgagggtggg            1110

ggctctgcag tcagacaaac ctaagatcac atcctggaca ggccacttgc ttgctgtgtg     1170

gcattgggca agtaacttta cctctctgga cttgtgataa taaaagttcc tacctcaaaa     1230

aaaaaaaaaa aaaa                                                       1244


<210>  384
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  384

Met Arg Ala Val Leu Ala Arg Glu Met Asp Gly Arg Arg Val Leu Gly 
1               5                   10                  15      


Arg Phe Trp Ser Gly Trp Arg Arg Gly Leu Gly Val Arg Pro Val Pro 
            20                  25                  30          


Glu Asp Ala Gly Phe Gly Thr Glu Ala Arg His Gln Arg Gln Pro Arg 
        35                  40                  45              


Gly Ser Cys Gln Arg Ser Gly Pro Leu Gly Asp Gln Pro Phe Ala Gly 
    50                  55                  60                  


Leu Leu Pro Lys Asn Leu Ser Arg Glu Glu Leu Val Asp Ala Leu Arg 
65                  70                  75                  80  


Ala Ala Val Val Asp Arg Lys Gly Pro Leu Val Thr Leu Asn Lys Pro 
                85                  90                  95      


Gln Gly Leu Pro Val Thr Gly Lys Pro Gly Glu Leu Thr Leu Phe Ser 
            100                 105                 110         


Val Leu Pro Glu Leu Ser Gln Ser Leu Gly Leu Arg Glu Gln Glu Leu 
        115                 120                 125             


Gln Val Val Arg Ala Ser Gly Lys Glu Ser Ser Gly Leu Val Leu Leu 
    130                 135                 140                 


Ser Ser Cys Pro Gln Thr Ala Ser Arg Leu Gln Lys Tyr Phe Thr His 
145                 150                 155                 160 


Ala Arg Arg Ala Gln Arg Pro Thr Ala Thr Tyr Cys Ala Val Thr Asp 
                165                 170                 175     


Gly Ile Pro Ala Ala Ser Glu Gly Lys Ile Gln Ala Ala Leu Lys Leu 
            180                 185                 190         


Glu His Ile Asp Gly Val Asn Leu Thr Val Pro Val Lys Ala Pro Ser 
        195                 200                 205             


Arg Lys Asp Ile Leu Glu Gly Val Lys Lys Thr Leu Ser His Phe Arg 
    210                 215                 220                 


Val Val Ala Thr Gly Ser Gly Cys Ala Leu Val Gln Leu Gln Pro Leu 
225                 230                 235                 240 


Thr Val Phe Ser Ser Gln Leu Gln Val His Met Val Leu Gln Leu Cys 
                245                 250                 255     


Pro Val Leu Gly Asp His Met Tyr Ser Ala Arg Val Gly Thr Val Leu 
            260                 265                 270         


Gly Gln Arg Phe Leu Leu Pro Ala Glu Asn Asn Lys Pro Gln Arg Gln 
        275                 280                 285             


Val Leu Asp Glu Ala Leu Leu Arg Arg Leu His Leu Thr Pro Ser Gln 
    290                 295                 300                 


Ala Ala Gln Leu Pro Leu His Leu His Leu His Arg Leu Leu Leu Pro 
305                 310                 315                 320 


Gly Thr Arg Ala Arg Asp Thr Pro Val Glu Leu Leu Ala Pro Leu Pro 
                325                 330                 335     


Pro Tyr Phe Ser Arg Thr Leu Gln Cys Leu Gly Leu Arg Leu Gln 
            340                 345                 350     


<210>  385
<211>  1483
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (462)..(1082)

<400>  385
ccgcggcacc cacgtgcagc ggctgggccc ggcgctttca ggggaccacc aggcccccag       60

agcgccgtgc tatgttgggg gctagtcact agcacggggc tggaagctga gatcaaagac      120

gccaatgagc cggcgtgggt ggatgagtga ggcgggcaag aagcagcacc ggttagcctg      180

agggttcgct ccagggccag gcctggagcc agcgccctta cctgcccctg gaaagtctga      240

gaccactcgg ggcggggcgg ctgccggagg gtgggctgcg gctccgtggc gggttccaga      300

ggggcggagc caagggctgg gcgttcccgc gggcggggcg tcccgggggc ggggcgggcc      360

cctgtgtttg ttgcaccgtg tcagttactt tgtaacaaaa gtgctgcagc cgcttgctcc      420

ggccggcacc ctaggccggc ccgccgccag ctgtcgccga c atg gaa ccc ttg gcc      476
                                              Met Glu Pro Leu Ala         
                                              1               5           

agc aac atc cag gtc ctg ctg cag gcg gcc gag ttc ctg gag cgc cgt        524
Ser Asn Ile Gln Val Leu Leu Gln Ala Ala Glu Phe Leu Glu Arg Arg           
                10                  15                  20                

gag aga gag gcc gag cat ggt tat gcg tcc ctg tgc ccg cat cgc agt        572
Glu Arg Glu Ala Glu His Gly Tyr Ala Ser Leu Cys Pro His Arg Ser           
            25                  30                  35                    

cca ggc ccc atc cac agg agg aag aag cga ccc ccc cag gct cct ggc        620
Pro Gly Pro Ile His Arg Arg Lys Lys Arg Pro Pro Gln Ala Pro Gly           
        40                  45                  50                        

gcg cag gac agc ggg cgg tca gtg cac aat gaa ctg gag aag cgc agg        668
Ala Gln Asp Ser Gly Arg Ser Val His Asn Glu Leu Glu Lys Arg Arg           
    55                  60                  65                            

agg gcc cag ttg aag cgg tgc ctg gag cgg ctg aag cag cag atg ccc        716
Arg Ala Gln Leu Lys Arg Cys Leu Glu Arg Leu Lys Gln Gln Met Pro           
70                  75                  80                  85            

ctg ggg gcc gac tgt gcc cgg tac acc acg ctg agc ctg ctg cgc cgt        764
Leu Gly Ala Asp Cys Ala Arg Tyr Thr Thr Leu Ser Leu Leu Arg Arg           
                90                  95                  100               

gcc agg atg cac atc cag aag ctg gag gat cag gag cag cgg gcc cga        812
Ala Arg Met His Ile Gln Lys Leu Glu Asp Gln Glu Gln Arg Ala Arg           
            105                 110                 115                   

cag ctc aag gag agg ctg cgc agc aag cag cag agc ctg cag cgg cag        860
Gln Leu Lys Glu Arg Leu Arg Ser Lys Gln Gln Ser Leu Gln Arg Gln           
        120                 125                 130                       

ctg gag cag ctc cgg ggg ctg gca ggg gcg gcc gag cgg gag cgg ctg        908
Leu Glu Gln Leu Arg Gly Leu Ala Gly Ala Ala Glu Arg Glu Arg Leu           
    135                 140                 145                           

cgg gcg gac agt ctg gac tcc tca ggc ctc tcc tct gag cgc tca gac        956
Arg Ala Asp Ser Leu Asp Ser Ser Gly Leu Ser Ser Glu Arg Ser Asp           
150                 155                 160                 165           

tca gac caa gag gag ctg gag gtg gat gtg gag agc ctg gtg ttt ggg       1004
Ser Asp Gln Glu Glu Leu Glu Val Asp Val Glu Ser Leu Val Phe Gly           
                170                 175                 180               

ggt gag gcc gag ctg ctg cgg ggc ttc gtc gcc ggc cag gag cac agc       1052
Gly Glu Ala Glu Leu Leu Arg Gly Phe Val Ala Gly Gln Glu His Ser           
            185                 190                 195                   

tac tcg cac ggc ggc ggc gcc tgg cta tga tgttcctcac ccagggcggg         1102
Tyr Ser His Gly Gly Gly Ala Trp Leu                                       
        200                 205                                           

cctctgccct ctactcgtgc caggcccact tgccaggcag gagccctccc caagccttca     1162

gggctgctcg gagtcacctg ttggaatgga ctaaaaggac ccttgtgtgg gaacaggtgc     1222

tccccaaaca ccctgctgct ggctgccagg caggccctct ggaagggaag gggcaggact     1282

catcaggacc tccctggacc cctgcagggc aggcagcttg ggcccgagcc caagcatttg     1342

gctctgctgc ccccaagggg acaggaagcc tcttgggcct cttcccttcc tggacaaggc     1402

cccctgcctt tgcctcacat aaactgtaca gtattttcat taaaagcctc tttcataact     1462

tccaaaaaaa aaaaaaaaaa a                                               1483


<210>  386
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  386

Met Glu Pro Leu Ala Ser Asn Ile Gln Val Leu Leu Gln Ala Ala Glu 
1               5                   10                  15      


Phe Leu Glu Arg Arg Glu Arg Glu Ala Glu His Gly Tyr Ala Ser Leu 
            20                  25                  30          


Cys Pro His Arg Ser Pro Gly Pro Ile His Arg Arg Lys Lys Arg Pro 
        35                  40                  45              


Pro Gln Ala Pro Gly Ala Gln Asp Ser Gly Arg Ser Val His Asn Glu 
    50                  55                  60                  


Leu Glu Lys Arg Arg Arg Ala Gln Leu Lys Arg Cys Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Gln Gln Met Pro Leu Gly Ala Asp Cys Ala Arg Tyr Thr Thr Leu 
                85                  90                  95      


Ser Leu Leu Arg Arg Ala Arg Met His Ile Gln Lys Leu Glu Asp Gln 
            100                 105                 110         


Glu Gln Arg Ala Arg Gln Leu Lys Glu Arg Leu Arg Ser Lys Gln Gln 
        115                 120                 125             


Ser Leu Gln Arg Gln Leu Glu Gln Leu Arg Gly Leu Ala Gly Ala Ala 
    130                 135                 140                 


Glu Arg Glu Arg Leu Arg Ala Asp Ser Leu Asp Ser Ser Gly Leu Ser 
145                 150                 155                 160 


Ser Glu Arg Ser Asp Ser Asp Gln Glu Glu Leu Glu Val Asp Val Glu 
                165                 170                 175     


Ser Leu Val Phe Gly Gly Glu Ala Glu Leu Leu Arg Gly Phe Val Ala 
            180                 185                 190         


Gly Gln Glu His Ser Tyr Ser His Gly Gly Gly Ala Trp Leu 
        195                 200                 205     


<210>  387
<211>  5041
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (238)..(2586)

<400>  387
aaaatggcgg ctgccactgt ggggcttctg ccggccggta gtccctggcg ctgctgaccc       60

agcatcggct tttctacgtc ttgaacctgg attcgcctag gggttgggaa gggctgtgga      120

cggcgttggg ggaggcctga cgagattaat aaagaactct tcagaattcc tggtgtttca      180

tcatatatac gactaagata tcaactcttc tagcttgctg tttctggacc aaaaaaa         237

atg acg tct att atc aaa tta act acc ctt tct ggg gtc caa gaa gaa        285
Met Thr Ser Ile Ile Lys Leu Thr Thr Leu Ser Gly Val Gln Glu Glu           
1               5                   10                  15                

tct gcc ctt tgc tat ctt ctc caa gtt gat gag ttt aga ttt tta ttg        333
Ser Ala Leu Cys Tyr Leu Leu Gln Val Asp Glu Phe Arg Phe Leu Leu           
            20                  25                  30                    

gac tgt ggc tgg gat gag cac ttt tct atg gat att att gat tcc ctg        381
Asp Cys Gly Trp Asp Glu His Phe Ser Met Asp Ile Ile Asp Ser Leu           
        35                  40                  45                        

agg aag cat gtt cac cag att gat gca gtg ctg ttg tct cac cct gat        429
Arg Lys His Val His Gln Ile Asp Ala Val Leu Leu Ser His Pro Asp           
    50                  55                  60                            

cct ctc cac ctt ggt gcc ctc ccg tat gct gtc gga aag ttg ggt ctg        477
Pro Leu His Leu Gly Ala Leu Pro Tyr Ala Val Gly Lys Leu Gly Leu           
65                  70                  75                  80            

aac tgt gct atc tat gca acc att cct gtt tat aaa atg gga cag atg        525
Asn Cys Ala Ile Tyr Ala Thr Ile Pro Val Tyr Lys Met Gly Gln Met           
                85                  90                  95                

ttc atg tat gat ctt tat cag tct cga cac aat aca gaa gat ttt aca        573
Phe Met Tyr Asp Leu Tyr Gln Ser Arg His Asn Thr Glu Asp Phe Thr           
            100                 105                 110                   

ctc ttt aca tta gat gat gtg gat gca gcc ttt gat aaa ata cag cag        621
Leu Phe Thr Leu Asp Asp Val Asp Ala Ala Phe Asp Lys Ile Gln Gln           
        115                 120                 125                       

cta aaa ttc tct cag att gtg aat ttg aaa ggt aaa gga cat ggc ctg        669
Leu Lys Phe Ser Gln Ile Val Asn Leu Lys Gly Lys Gly His Gly Leu           
    130                 135                 140                           

tct atc aca cct ctg cca gct ggt cat atg ata ggt gga aca ata tgg        717
Ser Ile Thr Pro Leu Pro Ala Gly His Met Ile Gly Gly Thr Ile Trp           
145                 150                 155                 160           

aaa ata gtc aaa gat gga gaa gaa gaa att gtt tat gca gtt gac ttc        765
Lys Ile Val Lys Asp Gly Glu Glu Glu Ile Val Tyr Ala Val Asp Phe           
                165                 170                 175               

aac cac aag agg gag atc cat tta aat gga tgt tcc ctg gaa atg cta        813
Asn His Lys Arg Glu Ile His Leu Asn Gly Cys Ser Leu Glu Met Leu           
            180                 185                 190                   

agc agg cct tcc cta ctt atc aca gat tca ttc aat gct aca tat gta        861
Ser Arg Pro Ser Leu Leu Ile Thr Asp Ser Phe Asn Ala Thr Tyr Val           
        195                 200                 205                       

cag cct aga aga aaa cag aga gat gag cag ctt ctg aca aat gtc ctg        909
Gln Pro Arg Arg Lys Gln Arg Asp Glu Gln Leu Leu Thr Asn Val Leu           
    210                 215                 220                           

gaa aca ctt cga ggt gat gga aat gtg tta ata gca gtg gac aca gca        957
Glu Thr Leu Arg Gly Asp Gly Asn Val Leu Ile Ala Val Asp Thr Ala           
225                 230                 235                 240           

ggc aga gtt ttg gaa ctt gct caa ctt ctt gat cag att tgg agg act       1005
Gly Arg Val Leu Glu Leu Ala Gln Leu Leu Asp Gln Ile Trp Arg Thr           
                245                 250                 255               

aaa gat gca gga ttg ggt gtt tac tca ttg gca ctc cta aat aat gtc       1053
Lys Asp Ala Gly Leu Gly Val Tyr Ser Leu Ala Leu Leu Asn Asn Val           
            260                 265                 270                   

agt tac aat gtg gtg gag ttt tct aag tcc cag gta gaa tgg atg agt       1101
Ser Tyr Asn Val Val Glu Phe Ser Lys Ser Gln Val Glu Trp Met Ser           
        275                 280                 285                       

gat aaa ttg atg aga tgt ttt gaa gac aaa aga aat aat ccg ttt cag       1149
Asp Lys Leu Met Arg Cys Phe Glu Asp Lys Arg Asn Asn Pro Phe Gln           
    290                 295                 300                           

ttt cgc cat ctc tct tta tgt cat ggt ctt tct gac ttg gcc cgt gta       1197
Phe Arg His Leu Ser Leu Cys His Gly Leu Ser Asp Leu Ala Arg Val           
305                 310                 315                 320           

cct agc cct aaa gtt gta ctt gcc agc caa cct gac ctg gaa tgc gga       1245
Pro Ser Pro Lys Val Val Leu Ala Ser Gln Pro Asp Leu Glu Cys Gly           
                325                 330                 335               

ttt tca agg gat ctc ttt att cag tgg tgt cag gac cct aaa aac tca       1293
Phe Ser Arg Asp Leu Phe Ile Gln Trp Cys Gln Asp Pro Lys Asn Ser           
            340                 345                 350                   

atc att cta acc tac aga act act cct ggg act tta gca cgt ttc cta       1341
Ile Ile Leu Thr Tyr Arg Thr Thr Pro Gly Thr Leu Ala Arg Phe Leu           
        355                 360                 365                       

att gat aat cct tct gaa aaa att aca gaa ata gag ttg agg aaa cgt       1389
Ile Asp Asn Pro Ser Glu Lys Ile Thr Glu Ile Glu Leu Arg Lys Arg           
    370                 375                 380                           

gtg aag ctt gaa ggg aaa gaa ctt gaa gaa tac ttg gaa aaa gag aaa       1437
Val Lys Leu Glu Gly Lys Glu Leu Glu Glu Tyr Leu Glu Lys Glu Lys           
385                 390                 395                 400           

cta aag aaa gaa gct gcc aaa aag ctt gag cag tca aaa gag gca gat       1485
Leu Lys Lys Glu Ala Ala Lys Lys Leu Glu Gln Ser Lys Glu Ala Asp           
                405                 410                 415               

ata gat tcc agt gat gag agt gat att gag gaa gat att gac cag cca       1533
Ile Asp Ser Ser Asp Glu Ser Asp Ile Glu Glu Asp Ile Asp Gln Pro           
            420                 425                 430                   

tca gct cat aag acg aag cat gac ttg atg atg aaa ggt gaa ggc agt       1581
Ser Ala His Lys Thr Lys His Asp Leu Met Met Lys Gly Glu Gly Ser           
        435                 440                 445                       

cgt aaa gga agt ttt ttc aaa cag gca aaa aag tcc tat cct atg ttt       1629
Arg Lys Gly Ser Phe Phe Lys Gln Ala Lys Lys Ser Tyr Pro Met Phe           
    450                 455                 460                           

cct gcc cca gaa gaa aga att aaa tgg gat gaa tat gga gag att atc       1677
Pro Ala Pro Glu Glu Arg Ile Lys Trp Asp Glu Tyr Gly Glu Ile Ile           
465                 470                 475                 480           

aaa cca gag gat ttc tta gtg cca gag ctt caa gct act gaa gaa gaa       1725
Lys Pro Glu Asp Phe Leu Val Pro Glu Leu Gln Ala Thr Glu Glu Glu           
                485                 490                 495               

aaa agc aaa tta gaa tct ggt ttg aca aat gga gat gaa cct atg gat       1773
Lys Ser Lys Leu Glu Ser Gly Leu Thr Asn Gly Asp Glu Pro Met Asp           
            500                 505                 510                   

cag gat tta tct gat gtt cct act aaa tgt att tct aca aca gag tct       1821
Gln Asp Leu Ser Asp Val Pro Thr Lys Cys Ile Ser Thr Thr Glu Ser           
        515                 520                 525                       

att gaa ata aaa gcc cgg gtt acc tac ata gac tat gaa gga cgc tct       1869
Ile Glu Ile Lys Ala Arg Val Thr Tyr Ile Asp Tyr Glu Gly Arg Ser           
    530                 535                 540                           

gat ggg gat tcc att aaa aaa atc att aat cag atg aaa cca cga cag       1917
Asp Gly Asp Ser Ile Lys Lys Ile Ile Asn Gln Met Lys Pro Arg Gln           
545                 550                 555                 560           

ttg atc atc gtc cat ggc cca cca gag gcc agt caa gat ctg gca gag       1965
Leu Ile Ile Val His Gly Pro Pro Glu Ala Ser Gln Asp Leu Ala Glu           
                565                 570                 575               

tgc tgt cgc gcc ttt ggt ggg aaa gat att aaa gtg tac atg cca aag       2013
Cys Cys Arg Ala Phe Gly Gly Lys Asp Ile Lys Val Tyr Met Pro Lys           
            580                 585                 590                   

cta cat gaa aca gtt gat gcc act agt gaa act cac atc tac cag gtg       2061
Leu His Glu Thr Val Asp Ala Thr Ser Glu Thr His Ile Tyr Gln Val           
        595                 600                 605                       

agg tta aaa gac tca ctt gtc agc tct ctt cag ttt tgt aag gca aaa       2109
Arg Leu Lys Asp Ser Leu Val Ser Ser Leu Gln Phe Cys Lys Ala Lys           
    610                 615                 620                           

gat gct gaa tta gct tgg ata gat ggt gtc tta gat atg aga gtt tcc       2157
Asp Ala Glu Leu Ala Trp Ile Asp Gly Val Leu Asp Met Arg Val Ser           
625                 630                 635                 640           

aaa gtg gac aca ggg gtt att tta gaa gaa gga gaa cta aag gat gat       2205
Lys Val Asp Thr Gly Val Ile Leu Glu Glu Gly Glu Leu Lys Asp Asp           
                645                 650                 655               

gga gaa gac tca gag atg caa gtg gaa gct ccc tca gat tct agc gtt       2253
Gly Glu Asp Ser Glu Met Gln Val Glu Ala Pro Ser Asp Ser Ser Val           
            660                 665                 670                   

ata gca caa caa aag gcc atg aaa agt ctg ttc gga gat gat gaa aaa       2301
Ile Ala Gln Gln Lys Ala Met Lys Ser Leu Phe Gly Asp Asp Glu Lys           
        675                 680                 685                       

gaa aca ggt gaa gaa agt gag atc att cct act ttg gaa ccc ttg cca       2349
Glu Thr Gly Glu Glu Ser Glu Ile Ile Pro Thr Leu Glu Pro Leu Pro           
    690                 695                 700                           

cct cat gag gtt cct gga cat cag tca gtt ttt atg aat gaa cca agg       2397
Pro His Glu Val Pro Gly His Gln Ser Val Phe Met Asn Glu Pro Arg           
705                 710                 715                 720           

ctg tca gac ttc aag caa gtt ctc tta cgg gag ggg att caa gct gaa       2445
Leu Ser Asp Phe Lys Gln Val Leu Leu Arg Glu Gly Ile Gln Ala Glu           
                725                 730                 735               

ttt gta gga ggt gta ctt gtt tgc aac aat caa gta gca gtc cgc aga       2493
Phe Val Gly Gly Val Leu Val Cys Asn Asn Gln Val Ala Val Arg Arg           
            740                 745                 750                   

acg gaa act gga cgc att gga tta gaa ggc tgc ctt tgt caa gat ttt       2541
Thr Glu Thr Gly Arg Ile Gly Leu Glu Gly Cys Leu Cys Gln Asp Phe           
        755                 760                 765                       

tat agg ata aga gac ctt tta tat gaa caa tat gcc att gta taa           2586
Tyr Arg Ile Arg Asp Leu Leu Tyr Glu Gln Tyr Ala Ile Val                   
    770                 775                 780                           

aggacatgat gtcaagaagt atctgcttga cctttctaag aaaaagggat tcttatctta     2646

ctctgagctt ttgatgtttt gttttgtaac atacaaaaag aatctgccag aaaaacttac     2706

atgtatcaga tttttaaaaa tataaataga gaacattttg caaatgctca aatgagcatt     2766

ctatcttttg gctttcagag tgatagagct cctaacaggt gtacaggccc aagagttgaa     2826

ggtgattggt tttctttaca gactccttgt tctctagaag ggctttttac ttgaataaaa     2886

caatgcaact tagcaaacca atttatggcc ttagagaaac atttttgcat gagttcttac     2946

aaactgtttg ttatattttc tggaatgata agtgagaatt atttagaaaa gacatgctcc     3006

aaaaaaaaaa caaaactgat aaaacagttt ttcgaaactt acttttaaaa gcatacgtgc     3066

tatgactctc tccagtttga atatgcaatt gttttcacag gcaggatgtc tgttttctgc     3126

ctgtatttcc cagtgattta ctctagggta aggtagtaca catttggttc agaaattaat     3186

ttttatttct cctatatctt gttttatcaa gattttgttg tggcatttca atgtaaatta     3246

taacaccatc atttgagtat acataattca aaagaactac ttgatgcagt atagtcttaa     3306

gggttctgca tacattttag aaacatctta gccgtaagtt aggtcctgtg ttaaactgtt     3366

tagtgctctg tttttaagaa aacaaatgtt gaacctcaca cttttatgtg gtgacagtgt     3426

aatttaatta aaaggtgtaa atgttttcat ctcttaggct tgctgtctcc taaggtcacc     3486

caagcagtgg ttggatttta tacacattac tactaaaata atactgaagt tggataaggt     3546

tatcctttct gtatttgcgt ctttcttgtg actaaccacc ctgatatagt attaaccact     3606

gtgttcaaga gtaaaaacaa tatatgcaat tttcattgaa cttaaagagt gaaaaccatg     3666

taaactattg aaactattgt aatccattaa tgctttttta gaatggcaga ccttgatgtt     3726

tatttctcaa atggttaagc cctcttcttt actcttaatt tttttttgag acagagtcac     3786

ccaggctgga gtgcagtggt gagattttgg ctcactataa cctcttcctc cagggttcaa     3846

gtgattctcc cacctcagcc tcccaagtag ctgggactac gggcacatgc cactgcacct     3906

ggctaatttt tatatttttg gtagagacag ggtttcacca tgttggccag gctggtctca     3966

aactcctgac ctcaagcgat ccacccacct aggcctccca aagtgctggg attacaggca     4026

tgaatcacca caactagcct acccttagat ttttggaagg atcgatctta tttaactatg     4086

tgtggaacaa cccagtaata tcagactcga attactattt cattctattt caaatgctta     4146

taaagctact attgtagatt atagtgttaa tgcaaagttt acagactttt gatatggaaa     4206

accagataaa acaatgttac aaaaggcaaa tataaagagt atgttttctt tttagtgctt     4266

tggaaaaatt tcacttaaac tcttattact gtatagatta agccctataa tgctatttat     4326

attccagggg aacgaaaatc tgaatttgtt ttatgattta aagcatctgg tttgcatatt     4386

gtattgtaat actgatacag tttggctgtg tccccaccaa attgaattgt gttaatagtt     4446

cccataatcc ctacgtgttg tgggagggac ccagtgggca gtaatttaat catggtggtg     4506

gttaccctca tgctgttctt gtgatggtga gttctcatga gatctgatgg gtgttttttt     4566

ttgttttgtt ttttgttttt tgagatggag ttttgctctt gttgcccaga ctggagtgca     4626

atggcacacg atctcggctc accgcaacct ctgcctcctg ggttcaagcg attctcctgc     4686

ctcagcatct cgagtagctg ggattacagg catgcaccac cacgcccagc taattttgta     4746

tttttagtag agacggggtt tctccatgtt ggttaggctg gcctcaaact cccgacctca     4806

ggtgatccgc ccgcctgggc ctcccaaagt gctgggatta caggcgtgag ccactgctcc     4866

tggcccaaga tctgatggtt ttgtaaggga attttccccc tttgcttggc acttcttcct     4926

gctgccatgt gaagaaggat gtgtttgctt ccccttccac catgattgta agtttcatga     4986

ggcctcccca gcctgtggga ctgtgagtca attaaacgtg tttactttat aaatt          5041


<210>  388
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  388

Met Thr Ser Ile Ile Lys Leu Thr Thr Leu Ser Gly Val Gln Glu Glu 
1               5                   10                  15      


Ser Ala Leu Cys Tyr Leu Leu Gln Val Asp Glu Phe Arg Phe Leu Leu 
            20                  25                  30          


Asp Cys Gly Trp Asp Glu His Phe Ser Met Asp Ile Ile Asp Ser Leu 
        35                  40                  45              


Arg Lys His Val His Gln Ile Asp Ala Val Leu Leu Ser His Pro Asp 
    50                  55                  60                  


Pro Leu His Leu Gly Ala Leu Pro Tyr Ala Val Gly Lys Leu Gly Leu 
65                  70                  75                  80  


Asn Cys Ala Ile Tyr Ala Thr Ile Pro Val Tyr Lys Met Gly Gln Met 
                85                  90                  95      


Phe Met Tyr Asp Leu Tyr Gln Ser Arg His Asn Thr Glu Asp Phe Thr 
            100                 105                 110         


Leu Phe Thr Leu Asp Asp Val Asp Ala Ala Phe Asp Lys Ile Gln Gln 
        115                 120                 125             


Leu Lys Phe Ser Gln Ile Val Asn Leu Lys Gly Lys Gly His Gly Leu 
    130                 135                 140                 


Ser Ile Thr Pro Leu Pro Ala Gly His Met Ile Gly Gly Thr Ile Trp 
145                 150                 155                 160 


Lys Ile Val Lys Asp Gly Glu Glu Glu Ile Val Tyr Ala Val Asp Phe 
                165                 170                 175     


Asn His Lys Arg Glu Ile His Leu Asn Gly Cys Ser Leu Glu Met Leu 
            180                 185                 190         


Ser Arg Pro Ser Leu Leu Ile Thr Asp Ser Phe Asn Ala Thr Tyr Val 
        195                 200                 205             


Gln Pro Arg Arg Lys Gln Arg Asp Glu Gln Leu Leu Thr Asn Val Leu 
    210                 215                 220                 


Glu Thr Leu Arg Gly Asp Gly Asn Val Leu Ile Ala Val Asp Thr Ala 
225                 230                 235                 240 


Gly Arg Val Leu Glu Leu Ala Gln Leu Leu Asp Gln Ile Trp Arg Thr 
                245                 250                 255     


Lys Asp Ala Gly Leu Gly Val Tyr Ser Leu Ala Leu Leu Asn Asn Val 
            260                 265                 270         


Ser Tyr Asn Val Val Glu Phe Ser Lys Ser Gln Val Glu Trp Met Ser 
        275                 280                 285             


Asp Lys Leu Met Arg Cys Phe Glu Asp Lys Arg Asn Asn Pro Phe Gln 
    290                 295                 300                 


Phe Arg His Leu Ser Leu Cys His Gly Leu Ser Asp Leu Ala Arg Val 
305                 310                 315                 320 


Pro Ser Pro Lys Val Val Leu Ala Ser Gln Pro Asp Leu Glu Cys Gly 
                325                 330                 335     


Phe Ser Arg Asp Leu Phe Ile Gln Trp Cys Gln Asp Pro Lys Asn Ser 
            340                 345                 350         


Ile Ile Leu Thr Tyr Arg Thr Thr Pro Gly Thr Leu Ala Arg Phe Leu 
        355                 360                 365             


Ile Asp Asn Pro Ser Glu Lys Ile Thr Glu Ile Glu Leu Arg Lys Arg 
    370                 375                 380                 


Val Lys Leu Glu Gly Lys Glu Leu Glu Glu Tyr Leu Glu Lys Glu Lys 
385                 390                 395                 400 


Leu Lys Lys Glu Ala Ala Lys Lys Leu Glu Gln Ser Lys Glu Ala Asp 
                405                 410                 415     


Ile Asp Ser Ser Asp Glu Ser Asp Ile Glu Glu Asp Ile Asp Gln Pro 
            420                 425                 430         


Ser Ala His Lys Thr Lys His Asp Leu Met Met Lys Gly Glu Gly Ser 
        435                 440                 445             


Arg Lys Gly Ser Phe Phe Lys Gln Ala Lys Lys Ser Tyr Pro Met Phe 
    450                 455                 460                 


Pro Ala Pro Glu Glu Arg Ile Lys Trp Asp Glu Tyr Gly Glu Ile Ile 
465                 470                 475                 480 


Lys Pro Glu Asp Phe Leu Val Pro Glu Leu Gln Ala Thr Glu Glu Glu 
                485                 490                 495     


Lys Ser Lys Leu Glu Ser Gly Leu Thr Asn Gly Asp Glu Pro Met Asp 
            500                 505                 510         


Gln Asp Leu Ser Asp Val Pro Thr Lys Cys Ile Ser Thr Thr Glu Ser 
        515                 520                 525             


Ile Glu Ile Lys Ala Arg Val Thr Tyr Ile Asp Tyr Glu Gly Arg Ser 
    530                 535                 540                 


Asp Gly Asp Ser Ile Lys Lys Ile Ile Asn Gln Met Lys Pro Arg Gln 
545                 550                 555                 560 


Leu Ile Ile Val His Gly Pro Pro Glu Ala Ser Gln Asp Leu Ala Glu 
                565                 570                 575     


Cys Cys Arg Ala Phe Gly Gly Lys Asp Ile Lys Val Tyr Met Pro Lys 
            580                 585                 590         


Leu His Glu Thr Val Asp Ala Thr Ser Glu Thr His Ile Tyr Gln Val 
        595                 600                 605             


Arg Leu Lys Asp Ser Leu Val Ser Ser Leu Gln Phe Cys Lys Ala Lys 
    610                 615                 620                 


Asp Ala Glu Leu Ala Trp Ile Asp Gly Val Leu Asp Met Arg Val Ser 
625                 630                 635                 640 


Lys Val Asp Thr Gly Val Ile Leu Glu Glu Gly Glu Leu Lys Asp Asp 
                645                 650                 655     


Gly Glu Asp Ser Glu Met Gln Val Glu Ala Pro Ser Asp Ser Ser Val 
            660                 665                 670         


Ile Ala Gln Gln Lys Ala Met Lys Ser Leu Phe Gly Asp Asp Glu Lys 
        675                 680                 685             


Glu Thr Gly Glu Glu Ser Glu Ile Ile Pro Thr Leu Glu Pro Leu Pro 
    690                 695                 700                 


Pro His Glu Val Pro Gly His Gln Ser Val Phe Met Asn Glu Pro Arg 
705                 710                 715                 720 


Leu Ser Asp Phe Lys Gln Val Leu Leu Arg Glu Gly Ile Gln Ala Glu 
                725                 730                 735     


Phe Val Gly Gly Val Leu Val Cys Asn Asn Gln Val Ala Val Arg Arg 
            740                 745                 750         


Thr Glu Thr Gly Arg Ile Gly Leu Glu Gly Cys Leu Cys Gln Asp Phe 
        755                 760                 765             


Tyr Arg Ile Arg Asp Leu Leu Tyr Glu Gln Tyr Ala Ile Val 
    770                 775                 780         


<210>  389
<211>  4925
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (135)..(3578)

<400>  389
accgcgcgcc actgtcttcg ccttcttgca cttcgcggga gaagttgttg gcgcgaatgg       60

atcctgagcc tcgataacag attcctcaac cggcccaccc gccagccagc cagcgccttc      120

atcctggggc tgcg atg gac att cgg aaa ttc ttt gga gta ata cca agt        170
                Met Asp Ile Arg Lys Phe Phe Gly Val Ile Pro Ser           
                1               5                   10                    

gga aag aaa ctt gta agt gaa aca gta aag aag aat gag aaa aca aag        218
Gly Lys Lys Leu Val Ser Glu Thr Val Lys Lys Asn Glu Lys Thr Lys           
        15                  20                  25                        

tct gat gaa gaa act tta aaa gca aag aaa gga ata aag gaa atc aag        266
Ser Asp Glu Glu Thr Leu Lys Ala Lys Lys Gly Ile Lys Glu Ile Lys           
    30                  35                  40                            

gta aat agc tcc cgt aaa gag gat gac ttc aaa caa aag caa cca agc        314
Val Asn Ser Ser Arg Lys Glu Asp Asp Phe Lys Gln Lys Gln Pro Ser           
45                  50                  55                  60            

aag aaa aag agg atc atc tat gat tca gat tca gag tca gag gag acg        362
Lys Lys Lys Arg Ile Ile Tyr Asp Ser Asp Ser Glu Ser Glu Glu Thr           
                65                  70                  75                

ttg cag gta aaa aat gcc aaa aag cca cca gaa aaa ctg cca gta tct        410
Leu Gln Val Lys Asn Ala Lys Lys Pro Pro Glu Lys Leu Pro Val Ser           
            80                  85                  90                    

tct aaa cct ggt aaa att tca cgg cag gat cct gtt aca tac att tca        458
Ser Lys Pro Gly Lys Ile Ser Arg Gln Asp Pro Val Thr Tyr Ile Ser           
        95                  100                 105                       

gaa aca gat gaa gaa gat gac ttt atg tgt aag aag gcg gcc tct aaa        506
Glu Thr Asp Glu Glu Asp Asp Phe Met Cys Lys Lys Ala Ala Ser Lys           
    110                 115                 120                           

tca aaa gag aat gga aga tct aca aat agt cat ctt gga aca tca aac        554
Ser Lys Glu Asn Gly Arg Ser Thr Asn Ser His Leu Gly Thr Ser Asn           
125                 130                 135                 140           

atg aaa aag aat gaa gaa aac act aag acc aag aat aag cct tta tca        602
Met Lys Lys Asn Glu Glu Asn Thr Lys Thr Lys Asn Lys Pro Leu Ser           
                145                 150                 155               

cca ata aaa ctt aca ccc aca tca gta ctt gat tat ttt gga act gga        650
Pro Ile Lys Leu Thr Pro Thr Ser Val Leu Asp Tyr Phe Gly Thr Gly           
            160                 165                 170                   

agt gtc caa aga tct aat aag aag atg gtg gca agc aaa aga aaa gag        698
Ser Val Gln Arg Ser Asn Lys Lys Met Val Ala Ser Lys Arg Lys Glu           
        175                 180                 185                       

ctt tca caa aat aca gat gag tct gga tta aat gat gaa gcc atc gcc        746
Leu Ser Gln Asn Thr Asp Glu Ser Gly Leu Asn Asp Glu Ala Ile Ala           
    190                 195                 200                           

aag caa tta cag ctt gat gaa gat gcg gag ctg gag agg cag ttg cat        794
Lys Gln Leu Gln Leu Asp Glu Asp Ala Glu Leu Glu Arg Gln Leu His           
205                 210                 215                 220           

gaa gat gaa gag ttt gcc aga aca tta gcc atg ttg gat gaa gaa ccc        842
Glu Asp Glu Glu Phe Ala Arg Thr Leu Ala Met Leu Asp Glu Glu Pro           
                225                 230                 235               

aag acc aaa aag gct cga aag gac aca gaa gcg gga gaa acg ttt tca        890
Lys Thr Lys Lys Ala Arg Lys Asp Thr Glu Ala Gly Glu Thr Phe Ser           
            240                 245                 250                   

tct gtc caa gcc aat tta agt aaa gca gaa aaa cat aaa tat cct cat        938
Ser Val Gln Ala Asn Leu Ser Lys Ala Glu Lys His Lys Tyr Pro His           
        255                 260                 265                       

aaa gta aaa aca gca caa gtt tca gat gaa aga aag agc tac agt cct        986
Lys Val Lys Thr Ala Gln Val Ser Asp Glu Arg Lys Ser Tyr Ser Pro           
    270                 275                 280                           

agg aag caa agt aaa tat gaa agt tca aaa gaa tct cag caa cat tcc       1034
Arg Lys Gln Ser Lys Tyr Glu Ser Ser Lys Glu Ser Gln Gln His Ser           
285                 290                 295                 300           

aag tca tca gct gac aaa ata gga gaa gtc tct tct ccc aag gcc agt       1082
Lys Ser Ser Ala Asp Lys Ile Gly Glu Val Ser Ser Pro Lys Ala Ser           
                305                 310                 315               

tct aag ctg gca att atg aaa aga aaa gaa gag agc tct tat aaa gaa       1130
Ser Lys Leu Ala Ile Met Lys Arg Lys Glu Glu Ser Ser Tyr Lys Glu           
            320                 325                 330                   

ata gag cct gtg gcc tca aaa aga aaa gaa aat gcc att aaa ttg aaa       1178
Ile Glu Pro Val Ala Ser Lys Arg Lys Glu Asn Ala Ile Lys Leu Lys           
        335                 340                 345                       

gga gag aca aaa act cct aag aaa acc aaa agt tct cca gct aaa aaa       1226
Gly Glu Thr Lys Thr Pro Lys Lys Thr Lys Ser Ser Pro Ala Lys Lys           
    350                 355                 360                           

gag tct gta agt cct gaa gat tct gaa aag aaa cgc act aat tat caa       1274
Glu Ser Val Ser Pro Glu Asp Ser Glu Lys Lys Arg Thr Asn Tyr Gln           
365                 370                 375                 380           

gct tat cga agc tac tta aat cga gaa ggt ccc aag gct ctg ggc tcc       1322
Ala Tyr Arg Ser Tyr Leu Asn Arg Glu Gly Pro Lys Ala Leu Gly Ser           
                385                 390                 395               

aaa gaa ata cca aag gga gct gaa aat tgc ttg gaa ggc ctt ata ttt       1370
Lys Glu Ile Pro Lys Gly Ala Glu Asn Cys Leu Glu Gly Leu Ile Phe           
            400                 405                 410                   

gta atc aca ggc gtg ctg gag tct att gaa cga gat gag gcc aag tct       1418
Val Ile Thr Gly Val Leu Glu Ser Ile Glu Arg Asp Glu Ala Lys Ser           
        415                 420                 425                       

cta att gaa cgt tat ggg gga aaa gta aca gga aat gtc agc aag aaa       1466
Leu Ile Glu Arg Tyr Gly Gly Lys Val Thr Gly Asn Val Ser Lys Lys           
    430                 435                 440                           

aca aat tat ctt gtc atg ggt cgt gat agt gga cag tcc aag agt gat       1514
Thr Asn Tyr Leu Val Met Gly Arg Asp Ser Gly Gln Ser Lys Ser Asp           
445                 450                 455                 460           

aag gcc gca gcc ttg ggg aca aaa att att gat gaa gat ggc ctg ttg       1562
Lys Ala Ala Ala Leu Gly Thr Lys Ile Ile Asp Glu Asp Gly Leu Leu           
                465                 470                 475               

aat ctg att cgg act atg cca ggc aag aaa tcc aag tat gaa ata gca       1610
Asn Leu Ile Arg Thr Met Pro Gly Lys Lys Ser Lys Tyr Glu Ile Ala           
            480                 485                 490                   

gtt gaa act gag atg aag aaa gag tcc aaa ctg gag aga aca ccc caa       1658
Val Glu Thr Glu Met Lys Lys Glu Ser Lys Leu Glu Arg Thr Pro Gln           
        495                 500                 505                       

aaa aat gtc caa gga aaa aga aaa att agt cca tct aaa aag gaa tca       1706
Lys Asn Val Gln Gly Lys Arg Lys Ile Ser Pro Ser Lys Lys Glu Ser           
    510                 515                 520                           

gaa tct aaa aag agc agg ccg act tcc aaa agg gac agt ttg gca aag       1754
Glu Ser Lys Lys Ser Arg Pro Thr Ser Lys Arg Asp Ser Leu Ala Lys           
525                 530                 535                 540           

aca ata aaa aag gaa aca gat gtg ttt tgg aaa agc ctg gat ttc aag       1802
Thr Ile Lys Lys Glu Thr Asp Val Phe Trp Lys Ser Leu Asp Phe Lys           
                545                 550                 555               

gag cag gtg gct gag gag aca agt ggt gac agc aag gct agg aat ttg       1850
Glu Gln Val Ala Glu Glu Thr Ser Gly Asp Ser Lys Ala Arg Asn Leu           
            560                 565                 570                   

gct gat gac agc agt gaa aac aaa gtg gaa aat ttg ctc tgg gtg gat       1898
Ala Asp Asp Ser Ser Glu Asn Lys Val Glu Asn Leu Leu Trp Val Asp           
        575                 580                 585                       

aaa tat aag cca acc tcg ctc aag acc ata att gga cag caa ggt gac       1946
Lys Tyr Lys Pro Thr Ser Leu Lys Thr Ile Ile Gly Gln Gln Gly Asp           
    590                 595                 600                           

cag agc tgt gcc aac aaa ctc cta cgc tgg ctc cga aac tgg caa aag       1994
Gln Ser Cys Ala Asn Lys Leu Leu Arg Trp Leu Arg Asn Trp Gln Lys           
605                 610                 615                 620           

agt tct tcc gaa gat aaa aaa cac gca aag ttt ggt aaa ttt tcc ggc       2042
Ser Ser Ser Glu Asp Lys Lys His Ala Lys Phe Gly Lys Phe Ser Gly           
                625                 630                 635               

aaa gat gat ggc tct agt ttt aaa gca gcg ttg ctg tca ggc cct cct       2090
Lys Asp Asp Gly Ser Ser Phe Lys Ala Ala Leu Leu Ser Gly Pro Pro           
            640                 645                 650                   

ggt gtt ggc aaa acc acc aca gct tcc ctg gtg tgt cag gag ttg gga       2138
Gly Val Gly Lys Thr Thr Thr Ala Ser Leu Val Cys Gln Glu Leu Gly           
        655                 660                 665                       

tac agc tac gtg gaa ctg aat gca agt gac acc cgg agt aag agc agt       2186
Tyr Ser Tyr Val Glu Leu Asn Ala Ser Asp Thr Arg Ser Lys Ser Ser           
    670                 675                 680                           

ttg aag gcg att gtt gct gag tca ctg aac aat acc agc atc aaa ggc       2234
Leu Lys Ala Ile Val Ala Glu Ser Leu Asn Asn Thr Ser Ile Lys Gly           
685                 690                 695                 700           

ttt tat tca aat gga gca gcc tct tca gta agc acg aaa cat gct ctc       2282
Phe Tyr Ser Asn Gly Ala Ala Ser Ser Val Ser Thr Lys His Ala Leu           
                705                 710                 715               

atc atg gat gaa gta gat ggc atg gca ggc aat gag gat agg gga gga       2330
Ile Met Asp Glu Val Asp Gly Met Ala Gly Asn Glu Asp Arg Gly Gly           
            720                 725                 730                   

att cag gaa tta att ggc ctg ata aaa cat act aaa att ccc att att       2378
Ile Gln Glu Leu Ile Gly Leu Ile Lys His Thr Lys Ile Pro Ile Ile           
        735                 740                 745                       

tgt atg tgc aat gat aga aat cat ccc aag att cgc tct ctg gtt cat       2426
Cys Met Cys Asn Asp Arg Asn His Pro Lys Ile Arg Ser Leu Val His           
    750                 755                 760                           

tat tgt ttt gat ctt cgt ttt caa aga cct cgg gtt gaa cag att aag       2474
Tyr Cys Phe Asp Leu Arg Phe Gln Arg Pro Arg Val Glu Gln Ile Lys           
765                 770                 775                 780           

ggt gct atg atg tct att gca ttt aaa gaa ggt tta aag att ccc cct       2522
Gly Ala Met Met Ser Ile Ala Phe Lys Glu Gly Leu Lys Ile Pro Pro           
                785                 790                 795               

cca gct atg aat gaa ata att ttg gga gcc aat caa gat atc aga cag       2570
Pro Ala Met Asn Glu Ile Ile Leu Gly Ala Asn Gln Asp Ile Arg Gln           
            800                 805                 810                   

gtt tta cat aat ctg agt atg tgg tgt gca cga agt aaa gca tta acc       2618
Val Leu His Asn Leu Ser Met Trp Cys Ala Arg Ser Lys Ala Leu Thr           
        815                 820                 825                       

tat gac cag gcc aaa gct gat tct cac aga gcc aaa aag gat atc aaa       2666
Tyr Asp Gln Ala Lys Ala Asp Ser His Arg Ala Lys Lys Asp Ile Lys           
    830                 835                 840                           

atg ggc cca ttt gat gtt gcc cgg aaa gtg ttt gca gct gga gag gag       2714
Met Gly Pro Phe Asp Val Ala Arg Lys Val Phe Ala Ala Gly Glu Glu           
845                 850                 855                 860           

act gct cac atg tca ctt gtg gac aag tca gat ctc ttt ttt cat gat       2762
Thr Ala His Met Ser Leu Val Asp Lys Ser Asp Leu Phe Phe His Asp           
                865                 870                 875               

tat tca ata gca ccc ctc ttc gtc cag gaa aat tac ata cac gtg aag       2810
Tyr Ser Ile Ala Pro Leu Phe Val Gln Glu Asn Tyr Ile His Val Lys           
            880                 885                 890                   

cct gta gca gca ggg ggt gac atg aaa aag cac ctg atg ctt tta agc       2858
Pro Val Ala Ala Gly Gly Asp Met Lys Lys His Leu Met Leu Leu Ser           
        895                 900                 905                       

aga gca gca gac agc ata tgc gat ggt gac cta gtg gac agc cag atc       2906
Arg Ala Ala Asp Ser Ile Cys Asp Gly Asp Leu Val Asp Ser Gln Ile           
    910                 915                 920                           

cgg agt aag caa aac tgg agt ctt ctg cct gcg cag gcc att tat gcc       2954
Arg Ser Lys Gln Asn Trp Ser Leu Leu Pro Ala Gln Ala Ile Tyr Ala           
925                 930                 935                 940           

agt gtt ctt cct gga gag ttg atg agg ggg tac atg acc cag ttt ccc       3002
Ser Val Leu Pro Gly Glu Leu Met Arg Gly Tyr Met Thr Gln Phe Pro           
                945                 950                 955               

acc ttc cca agc tgg ctg ggg aag cac tcg tct aca ggc aaa cat gat       3050
Thr Phe Pro Ser Trp Leu Gly Lys His Ser Ser Thr Gly Lys His Asp           
            960                 965                 970                   

cgt att gtt cag gac ctg gcc ttg cat atg agt ctc aga act tac tcc       3098
Arg Ile Val Gln Asp Leu Ala Leu His Met Ser Leu Arg Thr Tyr Ser           
        975                 980                 985                       

agc aaa agg act gta aac atg gat tat ctg tcg ctt  cta agg gat gca      3146
Ser Lys Arg Thr Val Asn Met Asp Tyr Leu Ser Leu  Leu Arg Asp Ala          
    990                 995                 1000                          

ctt  gta cag ccc ttg acc  tca caa gga gta gac  gga gta cag gat        3191
Leu  Val Gln Pro Leu Thr  Ser Gln Gly Val Asp  Gly Val Gln Asp            
1005                 1010                 1015                            

gtt  gtt gca ctt atg gac  aca tat tat ttg atg  aaa gaa gac ttt        3236
Val  Val Ala Leu Met Asp  Thr Tyr Tyr Leu Met  Lys Glu Asp Phe            
1020                 1025                 1030                            

gag  aat atc atg gaa atc  agc agc tgg ggt ggc  aaa cct agt ccc        3281
Glu  Asn Ile Met Glu Ile  Ser Ser Trp Gly Gly  Lys Pro Ser Pro            
1035                 1040                 1045                            

ttt  tca aag ctg gat ccc  aag gtg aaa gca gcc  ttc aca aga gct        3326
Phe  Ser Lys Leu Asp Pro  Lys Val Lys Ala Ala  Phe Thr Arg Ala            
1050                 1055                 1060                            

tac  aat aag gaa gcc cac  ctt act cca tac tca  ctt caa gct ata        3371
Tyr  Asn Lys Glu Ala His  Leu Thr Pro Tyr Ser  Leu Gln Ala Ile            
1065                 1070                 1075                            

aag  gca tct aga cac agc  aca agc cca tcc ctg  gat tcg gaa tac        3416
Lys  Ala Ser Arg His Ser  Thr Ser Pro Ser Leu  Asp Ser Glu Tyr            
1080                 1085                 1090                            

aat  gaa gaa tta aat gaa  gat gac tct caa tct  gat gag aaa gac        3461
Asn  Glu Glu Leu Asn Glu  Asp Asp Ser Gln Ser  Asp Glu Lys Asp            
1095                 1100                 1105                            

caa  gat gct ata gaa act  gat gcc atg atc aag  aaa aag aca aaa        3506
Gln  Asp Ala Ile Glu Thr  Asp Ala Met Ile Lys  Lys Lys Thr Lys            
1110                 1115                 1120                            

tct  tca aag cct tca aaa  cca gaa aaa gat aag  gag ccc aga aaa        3551
Ser  Ser Lys Pro Ser Lys  Pro Glu Lys Asp Lys  Glu Pro Arg Lys            
1125                 1130                 1135                            

gga  aaa gga aaa agt tcg  aag aaa tga aaccattttt cactagcgac           3598
Gly  Lys Gly Lys Ser Ser  Lys Lys                                         
1140                 1145                                                 

agccactttt tactctccct cctgaccagt ccagctggtc tagagaaagc cttgtttttt     3658

cccagagcaa ccatgtttta gcataatggg atgacctggt gtcccattat aaataaaggg     3718

tggtatggct agaagggtat gagcagtagg cttatgtaca cctcttatag aggttgatag     3778

gactgcttgg gtcctccact gtcctctgtc aatctagtta gacgtgcttc tgaatgactg     3838

tagaattgga actagaaact acacctgggc tttggagtca gattttagtt aacaataatg     3898

agcctgggag cagtagtact aaggcgtctt ttgtaggctt aagaatttat cctaatggcc     3958

tttataggac caatgctgat tttttttaaa ggcagttcct attatgtggt gaaattttgt     4018

aaataaatga ttatacaaaa cagtcaccac ctagaactgg gtattctttg tacattgtca     4078

gatatctttc aaagtataaa ttaggaataa aaatgttcca catgatatgt gtacaaattc     4138

tttttaagat tgtcatcttg tacagcaaaa tattatgttg gtatattact tccttattaa     4198

tttgcaaatg attggattaa aaaagctcac tgtattcctt actaacctgt tgtgtgaaac     4258

ataacattgg cagtcgagga gtcagaactc ggattcccag cctcactccc tctgtgtgtg     4318

ttgaccacgt ctctgctgtg aataggattt catgcagtgg tctgttatgg ggctttgcag     4378

cgtggggggc tgcagaagat tctcagacat tcttatcctt ctggagtctc aacccatcag     4438

gttcagacca gtaggaacca ggctgggtca ggctcttaat ttcactatgg tgggggacaa     4498

aatgaacact ggcttttgtt cactttgccc ctgagagatc tagtcctgtc ctgtgatggc     4558

ttccacaaac cctgttggaa gtttgggtta ttcctataac tgtatgtgtt gagtggccgt     4618

gaggctatgg acctagcctg gaatttagat gtctagctat tttttaatct tgttggtaaa     4678

tgctcagagg tctgtgctac ctctgtgagg tatatactaa aatgaatgta aaataaggat     4738

cgtattccct gctttaagga actggtagtc ttgtttgggt gatgagacaa agttcttgag     4798

acatttaaac tgtatttacc agtgtgaaaa atgtcattta tggagattaa ttcattatgg     4858

aaataaaaca ttgcctaagc ccttgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4918

aaaaaaa                                                               4925


<210>  390
<211>  1147
<212>  PRT
<213>  Homo sapiens

<400>  390

Met Asp Ile Arg Lys Phe Phe Gly Val Ile Pro Ser Gly Lys Lys Leu 
1               5                   10                  15      


Val Ser Glu Thr Val Lys Lys Asn Glu Lys Thr Lys Ser Asp Glu Glu 
            20                  25                  30          


Thr Leu Lys Ala Lys Lys Gly Ile Lys Glu Ile Lys Val Asn Ser Ser 
        35                  40                  45              


Arg Lys Glu Asp Asp Phe Lys Gln Lys Gln Pro Ser Lys Lys Lys Arg 
    50                  55                  60                  


Ile Ile Tyr Asp Ser Asp Ser Glu Ser Glu Glu Thr Leu Gln Val Lys 
65                  70                  75                  80  


Asn Ala Lys Lys Pro Pro Glu Lys Leu Pro Val Ser Ser Lys Pro Gly 
                85                  90                  95      


Lys Ile Ser Arg Gln Asp Pro Val Thr Tyr Ile Ser Glu Thr Asp Glu 
            100                 105                 110         


Glu Asp Asp Phe Met Cys Lys Lys Ala Ala Ser Lys Ser Lys Glu Asn 
        115                 120                 125             


Gly Arg Ser Thr Asn Ser His Leu Gly Thr Ser Asn Met Lys Lys Asn 
    130                 135                 140                 


Glu Glu Asn Thr Lys Thr Lys Asn Lys Pro Leu Ser Pro Ile Lys Leu 
145                 150                 155                 160 


Thr Pro Thr Ser Val Leu Asp Tyr Phe Gly Thr Gly Ser Val Gln Arg 
                165                 170                 175     


Ser Asn Lys Lys Met Val Ala Ser Lys Arg Lys Glu Leu Ser Gln Asn 
            180                 185                 190         


Thr Asp Glu Ser Gly Leu Asn Asp Glu Ala Ile Ala Lys Gln Leu Gln 
        195                 200                 205             


Leu Asp Glu Asp Ala Glu Leu Glu Arg Gln Leu His Glu Asp Glu Glu 
    210                 215                 220                 


Phe Ala Arg Thr Leu Ala Met Leu Asp Glu Glu Pro Lys Thr Lys Lys 
225                 230                 235                 240 


Ala Arg Lys Asp Thr Glu Ala Gly Glu Thr Phe Ser Ser Val Gln Ala 
                245                 250                 255     


Asn Leu Ser Lys Ala Glu Lys His Lys Tyr Pro His Lys Val Lys Thr 
            260                 265                 270         


Ala Gln Val Ser Asp Glu Arg Lys Ser Tyr Ser Pro Arg Lys Gln Ser 
        275                 280                 285             


Lys Tyr Glu Ser Ser Lys Glu Ser Gln Gln His Ser Lys Ser Ser Ala 
    290                 295                 300                 


Asp Lys Ile Gly Glu Val Ser Ser Pro Lys Ala Ser Ser Lys Leu Ala 
305                 310                 315                 320 


Ile Met Lys Arg Lys Glu Glu Ser Ser Tyr Lys Glu Ile Glu Pro Val 
                325                 330                 335     


Ala Ser Lys Arg Lys Glu Asn Ala Ile Lys Leu Lys Gly Glu Thr Lys 
            340                 345                 350         


Thr Pro Lys Lys Thr Lys Ser Ser Pro Ala Lys Lys Glu Ser Val Ser 
        355                 360                 365             


Pro Glu Asp Ser Glu Lys Lys Arg Thr Asn Tyr Gln Ala Tyr Arg Ser 
    370                 375                 380                 


Tyr Leu Asn Arg Glu Gly Pro Lys Ala Leu Gly Ser Lys Glu Ile Pro 
385                 390                 395                 400 


Lys Gly Ala Glu Asn Cys Leu Glu Gly Leu Ile Phe Val Ile Thr Gly 
                405                 410                 415     


Val Leu Glu Ser Ile Glu Arg Asp Glu Ala Lys Ser Leu Ile Glu Arg 
            420                 425                 430         


Tyr Gly Gly Lys Val Thr Gly Asn Val Ser Lys Lys Thr Asn Tyr Leu 
        435                 440                 445             


Val Met Gly Arg Asp Ser Gly Gln Ser Lys Ser Asp Lys Ala Ala Ala 
    450                 455                 460                 


Leu Gly Thr Lys Ile Ile Asp Glu Asp Gly Leu Leu Asn Leu Ile Arg 
465                 470                 475                 480 


Thr Met Pro Gly Lys Lys Ser Lys Tyr Glu Ile Ala Val Glu Thr Glu 
                485                 490                 495     


Met Lys Lys Glu Ser Lys Leu Glu Arg Thr Pro Gln Lys Asn Val Gln 
            500                 505                 510         


Gly Lys Arg Lys Ile Ser Pro Ser Lys Lys Glu Ser Glu Ser Lys Lys 
        515                 520                 525             


Ser Arg Pro Thr Ser Lys Arg Asp Ser Leu Ala Lys Thr Ile Lys Lys 
    530                 535                 540                 


Glu Thr Asp Val Phe Trp Lys Ser Leu Asp Phe Lys Glu Gln Val Ala 
545                 550                 555                 560 


Glu Glu Thr Ser Gly Asp Ser Lys Ala Arg Asn Leu Ala Asp Asp Ser 
                565                 570                 575     


Ser Glu Asn Lys Val Glu Asn Leu Leu Trp Val Asp Lys Tyr Lys Pro 
            580                 585                 590         


Thr Ser Leu Lys Thr Ile Ile Gly Gln Gln Gly Asp Gln Ser Cys Ala 
        595                 600                 605             


Asn Lys Leu Leu Arg Trp Leu Arg Asn Trp Gln Lys Ser Ser Ser Glu 
    610                 615                 620                 


Asp Lys Lys His Ala Lys Phe Gly Lys Phe Ser Gly Lys Asp Asp Gly 
625                 630                 635                 640 


Ser Ser Phe Lys Ala Ala Leu Leu Ser Gly Pro Pro Gly Val Gly Lys 
                645                 650                 655     


Thr Thr Thr Ala Ser Leu Val Cys Gln Glu Leu Gly Tyr Ser Tyr Val 
            660                 665                 670         


Glu Leu Asn Ala Ser Asp Thr Arg Ser Lys Ser Ser Leu Lys Ala Ile 
        675                 680                 685             


Val Ala Glu Ser Leu Asn Asn Thr Ser Ile Lys Gly Phe Tyr Ser Asn 
    690                 695                 700                 


Gly Ala Ala Ser Ser Val Ser Thr Lys His Ala Leu Ile Met Asp Glu 
705                 710                 715                 720 


Val Asp Gly Met Ala Gly Asn Glu Asp Arg Gly Gly Ile Gln Glu Leu 
                725                 730                 735     


Ile Gly Leu Ile Lys His Thr Lys Ile Pro Ile Ile Cys Met Cys Asn 
            740                 745                 750         


Asp Arg Asn His Pro Lys Ile Arg Ser Leu Val His Tyr Cys Phe Asp 
        755                 760                 765             


Leu Arg Phe Gln Arg Pro Arg Val Glu Gln Ile Lys Gly Ala Met Met 
    770                 775                 780                 


Ser Ile Ala Phe Lys Glu Gly Leu Lys Ile Pro Pro Pro Ala Met Asn 
785                 790                 795                 800 


Glu Ile Ile Leu Gly Ala Asn Gln Asp Ile Arg Gln Val Leu His Asn 
                805                 810                 815     


Leu Ser Met Trp Cys Ala Arg Ser Lys Ala Leu Thr Tyr Asp Gln Ala 
            820                 825                 830         


Lys Ala Asp Ser His Arg Ala Lys Lys Asp Ile Lys Met Gly Pro Phe 
        835                 840                 845             


Asp Val Ala Arg Lys Val Phe Ala Ala Gly Glu Glu Thr Ala His Met 
    850                 855                 860                 


Ser Leu Val Asp Lys Ser Asp Leu Phe Phe His Asp Tyr Ser Ile Ala 
865                 870                 875                 880 


Pro Leu Phe Val Gln Glu Asn Tyr Ile His Val Lys Pro Val Ala Ala 
                885                 890                 895     


Gly Gly Asp Met Lys Lys His Leu Met Leu Leu Ser Arg Ala Ala Asp 
            900                 905                 910         


Ser Ile Cys Asp Gly Asp Leu Val Asp Ser Gln Ile Arg Ser Lys Gln 
        915                 920                 925             


Asn Trp Ser Leu Leu Pro Ala Gln Ala Ile Tyr Ala Ser Val Leu Pro 
    930                 935                 940                 


Gly Glu Leu Met Arg Gly Tyr Met Thr Gln Phe Pro Thr Phe Pro Ser 
945                 950                 955                 960 


Trp Leu Gly Lys His Ser Ser Thr Gly Lys His Asp Arg Ile Val Gln 
                965                 970                 975     


Asp Leu Ala Leu His Met Ser Leu Arg Thr Tyr Ser Ser Lys Arg Thr 
            980                 985                 990         


Val Asn Met Asp Tyr Leu Ser Leu  Leu Arg Asp Ala Leu  Val Gln Pro 
        995                 1000                 1005             


Leu Thr  Ser Gln Gly Val Asp  Gly Val Gln Asp Val  Val Ala Leu 
    1010                 1015                 1020             


Met Asp  Thr Tyr Tyr Leu Met  Lys Glu Asp Phe Glu  Asn Ile Met 
    1025                 1030                 1035             


Glu Ile  Ser Ser Trp Gly Gly  Lys Pro Ser Pro Phe  Ser Lys Leu 
    1040                 1045                 1050             


Asp Pro  Lys Val Lys Ala Ala  Phe Thr Arg Ala Tyr  Asn Lys Glu 
    1055                 1060                 1065             


Ala His  Leu Thr Pro Tyr Ser  Leu Gln Ala Ile Lys  Ala Ser Arg 
    1070                 1075                 1080             


His Ser  Thr Ser Pro Ser Leu  Asp Ser Glu Tyr Asn  Glu Glu Leu 
    1085                 1090                 1095             


Asn Glu  Asp Asp Ser Gln Ser  Asp Glu Lys Asp Gln  Asp Ala Ile 
    1100                 1105                 1110             


Glu Thr  Asp Ala Met Ile Lys  Lys Lys Thr Lys Ser  Ser Lys Pro 
    1115                 1120                 1125             


Ser Lys  Pro Glu Lys Asp Lys  Glu Pro Arg Lys Gly  Lys Gly Lys 
    1130                 1135                 1140             


Ser Ser  Lys Lys 
    1145         


<210>  391
<211>  2653
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (101)..(2233)

<400>  391
atgttgtgat ggagaagccg cggcggagcc cgaaccccgc agcctgagcc acctccgtca       60

tctgggcccg gggcctcacc gcgcaggagc tgccaaggcc atg tct gtt cca tca        115
                                            Met Ser Val Pro Ser           
                                            1               5             

tca ctg agc cag tcg gcc att aat gcc aac agc cac gga ggc ccc gca        163
Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser His Gly Gly Pro Ala           
                10                  15                  20                

ctg agc cta ccc ctg cct ctg cac gct gcc cac aac cag ctg ctc aac        211
Leu Ser Leu Pro Leu Pro Leu His Ala Ala His Asn Gln Leu Leu Asn           
            25                  30                  35                    

gcc aag ctg cag gcc aca gct gtg gga ccc aag gac ctg cgc agc gcc        259
Ala Lys Leu Gln Ala Thr Ala Val Gly Pro Lys Asp Leu Arg Ser Ala           
        40                  45                  50                        

atg ggg gag ggt ggt ggg cct gag cca ggc cct gcc aat gcc aag tgg        307
Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro Ala Asn Ala Lys Trp           
    55                  60                  65                            

cta aaa gag ggc cag aac cag ctc cgg cgg gcc gcc acg gcc cac cgt        355
Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala Ala Thr Ala His Arg           
70                  75                  80                  85            

gac cag aat cgc aat gtg acc ttg acc ttg gcg gag gag gcc agc cag        403
Asp Gln Asn Arg Asn Val Thr Leu Thr Leu Ala Glu Glu Ala Ser Gln           
                90                  95                  100               

gag cct gag atg gca ccc ttg ggc ccc aaa ggc ctg ata cac ctg tac        451
Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly Leu Ile His Leu Tyr           
            105                 110                 115                   

tct gag ctg gag ctc tca gct cac aac gca gcc aac cga ggc cta cga        499
Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala Asn Arg Gly Leu Arg           
        120                 125                 130                       

gga cct ggc ctg atc atc agc act caa gag cag ggg cca gat gag gga        547
Gly Pro Gly Leu Ile Ile Ser Thr Gln Glu Gln Gly Pro Asp Glu Gly           
    135                 140                 145                           

gag gag aag gcg gcc ggg gag gcc gag gag gag gag gag gat gat gat        595
Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu Glu Glu Asp Asp Asp           
150                 155                 160                 165           

gat gaa gag gag gag gag gac tta tct tct ccc cca ggg ctg cct gag        643
Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro Pro Gly Leu Pro Glu           
                170                 175                 180               

ccc ctg gag agt gtg gag gcc cct ccc agg ccc caa gcc ctt aca gat        691
Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro Gln Ala Leu Thr Asp           
            185                 190                 195                   

ggc ccc cgg gaa cac agc aag agt gcc agc ctc ctg ttt ggc atg cgg        739
Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu Leu Phe Gly Met Arg           
        200                 205                 210                       

aac agt gca gcc agt gat gag gac tca agc tgg gct acc tta tcc cag        787
Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp Ala Thr Leu Ser Gln           
    215                 220                 225                           

ggc agc ccc tcc tat ggc tcc cca gag gac aca gat tcc ttc tgg aac        835
Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr Asp Ser Phe Trp Asn           
230                 235                 240                 245           

ccc aac gcc ttc gag acg gat tcc gac ctg ccg gct gga tgg atg agg        883
Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro Ala Gly Trp Met Arg           
                250                 255                 260               

gtc cag gac acc tca ggg acc tat tac tgg cac atc cca aca ggg acc        931
Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His Ile Pro Thr Gly Thr           
            265                 270                 275                   

acc cag tgg gaa ccc ccc ggc cgg gcc tcc ccc tca cag ggg agc agc        979
Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro Ser Gln Gly Ser Ser           
        280                 285                 290                       

ccc caa gag gag tcc cag ctc acc tgg aca ggt ttt gct cat gga gaa       1027
Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly Phe Ala His Gly Glu           
    295                 300                 305                           

ggc ttt gag gat gga gaa ttt tgg aag gat gaa ccc agt gat gag gcc       1075
Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu Pro Ser Asp Glu Ala           
310                 315                 320                 325           

cca atg gag ctg gga ctg aag gaa cct gag gag ggg acg ttg acc ttc       1123
Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu Gly Thr Leu Thr Phe           
                330                 335                 340               

cca gct cag agc ctc agc cca gag ccg ttg ccc caa gag gag gag aag       1171
Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro Gln Glu Glu Glu Lys           
            345                 350                 355                   

ctt ccc cca cgg aat acc aac cca ggg atc aag tgt ttc gcc gtg cgc       1219
Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys Cys Phe Ala Val Arg           
        360                 365                 370                       

tcc cta ggc tgg gta gag atg acc gag gag gag ctg gcc cct gga cgc       1267
Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu Leu Ala Pro Gly Arg           
    375                 380                 385                           

agc agt gtg gca gtc aac aat tgc atc cgt cag ctc tct tac cac aaa       1315
Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln Leu Ser Tyr His Lys           
390                 395                 400                 405           

aac aac ctg cat gac ccc atg tct ggg ggc tgg ggg gaa gga aag gat       1363
Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp Gly Glu Gly Lys Asp           
                410                 415                 420               

ctg cta ctg cag ctg gag gat gag aca cta aag cta gtg gag cca cag       1411
Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys Leu Val Glu Pro Gln           
            425                 430                 435                   

agc cag gca ctg ctg cac gcc caa ccc atc atc agc atc cgc gtg tgg       1459
Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile Ser Ile Arg Val Trp           
        440                 445                 450                       

ggc gtc ggg cgg gac agt gga aga gag agg gac ttt gcc tac gta gct       1507
Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp Phe Ala Tyr Val Ala           
    455                 460                 465                           

cgt gat aag ctg acc cag atg ctc aag tgc cac gtg ttt cgc tgt gag       1555
Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His Val Phe Arg Cys Glu           
470                 475                 480                 485           

gca cct gcc aag aac atc gcc acc agc ctg cat gag atc tgc tct aag       1603
Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His Glu Ile Cys Ser Lys           
                490                 495                 500               

atc atg gcc gaa cgg cgt aat gcc cgc tgc ttg gta aat gga ctc tcc       1651
Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu Val Asn Gly Leu Ser           
            505                 510                 515                   

ctg gac cac tct aaa ctt gtg gat gtc cct ttc caa gtg gaa ttc cca       1699
Leu Asp His Ser Lys Leu Val Asp Val Pro Phe Gln Val Glu Phe Pro           
        520                 525                 530                       

gcg cct aag aat gag ttg gtc cag aag ttc caa gtc tat tac ctg ggg       1747
Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln Val Tyr Tyr Leu Gly           
    535                 540                 545                           

aat gta cct gtt gct aaa cct gtt ggg gta gat gtg att aat ggg gcc       1795
Asn Val Pro Val Ala Lys Pro Val Gly Val Asp Val Ile Asn Gly Ala           
550                 555                 560                 565           

ctc gag tca gtc ctg tcc tcc agc agc cgt gaa caa tgg acc cca agt       1843
Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu Gln Trp Thr Pro Ser           
                570                 575                 580               

cat gtc agt gtg gcc cct gct acc ctc acc atc ttg cac cag cag aca       1891
His Val Ser Val Ala Pro Ala Thr Leu Thr Ile Leu His Gln Gln Thr           
            585                 590                 595                   

gag gca gtg ctg gga gag tgt cgg gtg cgt ttc ctc tcc ttc ctg gcc       1939
Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe Leu Ser Phe Leu Ala           
        600                 605                 610                       

gtg ggc aga gat gtc cac acg ttt gca ttc atc atg gct gcc ggc cca       1987
Val Gly Arg Asp Val His Thr Phe Ala Phe Ile Met Ala Ala Gly Pro           
    615                 620                 625                           

gcc tcc ttc tgc tgc cac atg ttc tgg tgc gag ccc aat gct gcc agc       2035
Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu Pro Asn Ala Ala Ser           
630                 635                 640                 645           

ctc tca gag gct gtg cag gct gcg tgc atg ctt cgc tac cag aag tgt       2083
Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr Gln Lys Cys           
                650                 655                 660               

ctg gat gcc cgt tcc cag gcc tcc acc tcc tgc ctc cca gca ccc cct       2131
Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys Leu Pro Ala Pro Pro           
            665                 670                 675                   

gct gag tct gtg gca cgg cgt gta ggg tgg act gtc cgc agg ggt gtt       2179
Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr Val Arg Arg Gly Val           
        680                 685                 690                       

cag tcg ctg tgg ggc tcc ctg aag ccc aaa cgg ctg ggg gcc cat acc       2227
Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg Leu Gly Ala His Thr           
    695                 700                 705                           

cca tga agaagccccc accttccctc cacctgcttg tgttgggccc cagggaacta        2283
Pro                                                                       
710                                                                       

aagggtgtgg gtcagggagg ggtctagagg ctattcctag gcctcaggcc tcccaaatat     2343

gcccctcccc agtagctacg gttccctgcc taggagctgg ggagggagag atctaatccc     2403

ttcaaggaag tgataacact ggagtggtaa caagaggagc aggaagcaag gccagccctg     2463

gttctccatc cccatgtgtt tcaggtggaa caggaggaac tggtccaggc caggcctcat     2523

cctcctggac ccagcagggg cagaaggagg aagggactgg tccaggcatg ggtcccttcc     2583

ccctgctcca tgggcacctc tgctgtattg atatcactaa taaagtctgt ctgcactgca     2643

aaaaaaaaaa                                                            2653


<210>  392
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  392

Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
1               5                   10                  15      


His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
            20                  25                  30          


Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Thr Ala Val Gly Pro Lys 
        35                  40                  45              


Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
    50                  55                  60                  


Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
65                  70                  75                  80  


Ala Thr Ala His Arg Asp Gln Asn Arg Asn Val Thr Leu Thr Leu Ala 
                85                  90                  95      


Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
            100                 105                 110         


Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
        115                 120                 125             


Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Thr Gln Glu Gln 
    130                 135                 140                 


Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                165                 170                 175     


Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
            180                 185                 190         


Gln Ala Leu Thr Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
        195                 200                 205             


Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
    210                 215                 220                 


Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr 
225                 230                 235                 240 


Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro 
                245                 250                 255     


Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His 
            260                 265                 270         


Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
        275                 280                 285             


Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly 
    290                 295                 300                 


Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
305                 310                 315                 320 


Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                325                 330                 335     


Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
            340                 345                 350         


Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys 
        355                 360                 365             


Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu 
    370                 375                 380                 


Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
385                 390                 395                 400 


Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                405                 410                 415     


Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys 
            420                 425                 430         


Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
        435                 440                 445             


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp 
    450                 455                 460                 


Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His 
465                 470                 475                 480 


Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His 
                485                 490                 495     


Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu 
            500                 505                 510         


Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
        515                 520                 525             


Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
    530                 535                 540                 


Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
545                 550                 555                 560 


Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
                565                 570                 575     


Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile 
            580                 585                 590         


Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
        595                 600                 605             


Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile 
    610                 615                 620                 


Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
625                 630                 635                 640 


Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
                645                 650                 655     


Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys 
            660                 665                 670         


Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr 
        675                 680                 685             


Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg 
    690                 695                 700                 


Leu Gly Ala His Thr Pro 
705                 710 


<210>  393
<211>  2907
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (84)..(2123)

<400>  393
cagactgtgg agccgggagc cggcagtaag cccagaggtc tccaccccac gggaggaagg       60

ctgaggccaa gaccccggaa gag atg gac cgc gtg acc aga tac ccc atc ctg      113
                          Met Asp Arg Val Thr Arg Tyr Pro Ile Leu         
                          1               5                   10          

ggc atc cct cag gca cac cgt ggc acc ggc ctg gtg ctg gat gga gac        161
Gly Ile Pro Gln Ala His Arg Gly Thr Gly Leu Val Leu Asp Gly Asp           
                15                  20                  25                

acc agc tac aca tac cat ctg gtg tgc atg ggc ccc gag gcc agc ggc        209
Thr Ser Tyr Thr Tyr His Leu Val Cys Met Gly Pro Glu Ala Ser Gly           
            30                  35                  40                    

tgg ggc cag gat gag ccg cag aca tgg ccc act gac cac agg gcc cag        257
Trp Gly Gln Asp Glu Pro Gln Thr Trp Pro Thr Asp His Arg Ala Gln           
        45                  50                  55                        

cag ggc gtg cag agg cag ggg gtg tcc tac agc gtg cat gcc tac act        305
Gln Gly Val Gln Arg Gln Gly Val Ser Tyr Ser Val His Ala Tyr Thr           
    60                  65                  70                            

ggc cag ccg tcc cca cgg ggg ctc cac tcg gag aac agg gag gat gag        353
Gly Gln Pro Ser Pro Arg Gly Leu His Ser Glu Asn Arg Glu Asp Glu           
75                  80                  85                  90            

ggt tgg cag gtt tac cgc ctg ggc gcc agg gat gcc cac cag gga cgt        401
Gly Trp Gln Val Tyr Arg Leu Gly Ala Arg Asp Ala His Gln Gly Arg           
                95                  100                 105               

cca aca tgg gca ctc cgc cca gag gac ggg gag gac aag gag atg aag        449
Pro Thr Trp Ala Leu Arg Pro Glu Asp Gly Glu Asp Lys Glu Met Lys           
            110                 115                 120                   

acc tac cgc ctg gat gct ggg gac gct gac ccc agg agg ctg tgt gac        497
Thr Tyr Arg Leu Asp Ala Gly Asp Ala Asp Pro Arg Arg Leu Cys Asp           
        125                 130                 135                       

ctg gag cgg gag cgc tgg gcc gtc atc cag ggc cag gca gtc agg aag        545
Leu Glu Arg Glu Arg Trp Ala Val Ile Gln Gly Gln Ala Val Arg Lys           
    140                 145                 150                           

agc agc acc gtg gcc acg ctc cag ggc act cct gac cac gga gac ccc        593
Ser Ser Thr Val Ala Thr Leu Gln Gly Thr Pro Asp His Gly Asp Pro           
155                 160                 165                 170           

agg acc ccc ggc cca cct cgg tcc acg ccc ctg gag gag aac gtg gtt        641
Arg Thr Pro Gly Pro Pro Arg Ser Thr Pro Leu Glu Glu Asn Val Val           
                175                 180                 185               

gac agg gag cag att gac ttc ctg gca gcg aga cag cag ttc ctg agt        689
Asp Arg Glu Gln Ile Asp Phe Leu Ala Ala Arg Gln Gln Phe Leu Ser           
            190                 195                 200                   

ctg gag cag gcg aac aag ggg gcc cct cat agc tcc ccg gcc agg ggg        737
Leu Glu Gln Ala Asn Lys Gly Ala Pro His Ser Ser Pro Ala Arg Gly           
        205                 210                 215                       

acc cct gca ggc aca acc cca ggg gcc agc cag gcc ccc aag gcc ttc        785
Thr Pro Ala Gly Thr Thr Pro Gly Ala Ser Gln Ala Pro Lys Ala Phe           
    220                 225                 230                           

aac aag ccc cac ctg gcc aac ggg cac gtg gtt ccc atc aag ccc cag        833
Asn Lys Pro His Leu Ala Asn Gly His Val Val Pro Ile Lys Pro Gln           
235                 240                 245                 250           

gtg aag ggg gtg gtc agg gaa gag aac aag gtg cgt gct gtg ccc acc        881
Val Lys Gly Val Val Arg Glu Glu Asn Lys Val Arg Ala Val Pro Thr           
                255                 260                 265               

tgg gcc agt gtc caa gtt gtg gat gac cct ggc tcc ttg gcc tca gtg        929
Trp Ala Ser Val Gln Val Val Asp Asp Pro Gly Ser Leu Ala Ser Val           
            270                 275                 280                   

gag tcc ccg ggg acc ccc aag gag acg ccc atc gag cgg gag atc cgt        977
Glu Ser Pro Gly Thr Pro Lys Glu Thr Pro Ile Glu Arg Glu Ile Arg           
        285                 290                 295                       

ctg gct cag gag cgt gag gca gac ctg cga gag cag agg ggg ctt cgg       1025
Leu Ala Gln Glu Arg Glu Ala Asp Leu Arg Glu Gln Arg Gly Leu Arg           
    300                 305                 310                           

cag gca acc gac cac cag gag ctg gtg gaa atc ccc acc agg ccg ctg       1073
Gln Ala Thr Asp His Gln Glu Leu Val Glu Ile Pro Thr Arg Pro Leu           
315                 320                 325                 330           

ctg acc aag ctg agc ctg atc aca gcc cca cgg cgg gag aga ggg cgc       1121
Leu Thr Lys Leu Ser Leu Ile Thr Ala Pro Arg Arg Glu Arg Gly Arg           
                335                 340                 345               

ccg tcc ctc tac gtg cag cgg gac ata gta cag gag aca cag cgt gag       1169
Pro Ser Leu Tyr Val Gln Arg Asp Ile Val Gln Glu Thr Gln Arg Glu           
            350                 355                 360                   

gaa gac cac cgg cgg gag ggc ctg cac gtg ggc cgg gcg tcc aca ccc       1217
Glu Asp His Arg Arg Glu Gly Leu His Val Gly Arg Ala Ser Thr Pro           
        365                 370                 375                       

gac tgg gtc tcg gag ggt ccc cag ccc gga ctc cgg aga gcc ctc agc       1265
Asp Trp Val Ser Glu Gly Pro Gln Pro Gly Leu Arg Arg Ala Leu Ser           
    380                 385                 390                           

tca gat tcc atc ctc agc ccg gcc cca gat gcc cgt gcg gcc gac cca       1313
Ser Asp Ser Ile Leu Ser Pro Ala Pro Asp Ala Arg Ala Ala Asp Pro           
395                 400                 405                 410           

gct cca gaa gtg agg aag gtg aac cgc atc cca cct gat gcc tac cag       1361
Ala Pro Glu Val Arg Lys Val Asn Arg Ile Pro Pro Asp Ala Tyr Gln           
                415                 420                 425               

ccg tac ctg agc ccc ggg acc ccc cag cta gaa ttc tca gcc ttc gga       1409
Pro Tyr Leu Ser Pro Gly Thr Pro Gln Leu Glu Phe Ser Ala Phe Gly           
            430                 435                 440                   

gca ttc ggc aag ccc agc agt ctc tcc aca gcg gag gcc aag gct gcg       1457
Ala Phe Gly Lys Pro Ser Ser Leu Ser Thr Ala Glu Ala Lys Ala Ala           
        445                 450                 455                       

act tca cca aag gcc acg atg tcc ccg agg cat ctc tca gaa tcc tct       1505
Thr Ser Pro Lys Ala Thr Met Ser Pro Arg His Leu Ser Glu Ser Ser           
    460                 465                 470                           

gga aaa ccc ctg agc aca aag caa gag gca tcg aag ccc cct cgg gga       1553
Gly Lys Pro Leu Ser Thr Lys Gln Glu Ala Ser Lys Pro Pro Arg Gly           
475                 480                 485                 490           

tgc ccg caa gcc aac agg ggt gtc gtg cgg tgg gag tac ttc cgc ctg       1601
Cys Pro Gln Ala Asn Arg Gly Val Val Arg Trp Glu Tyr Phe Arg Leu           
                495                 500                 505               

cgt cct ctg cgg ttc agg gcc cca gac gag ccc cag cag gcc caa gtc       1649
Arg Pro Leu Arg Phe Arg Ala Pro Asp Glu Pro Gln Gln Ala Gln Val           
            510                 515                 520                   

ccc cat gtc tgg ggc tgg gag gtg gct ggg gcc cct gca ctg agg ctg       1697
Pro His Val Trp Gly Trp Glu Val Ala Gly Ala Pro Ala Leu Arg Leu           
        525                 530                 535                       

cag aag tcc cag tca tct gat ctg ctg gaa agg gag agg gag agt gtc       1745
Gln Lys Ser Gln Ser Ser Asp Leu Leu Glu Arg Glu Arg Glu Ser Val           
    540                 545                 550                           

ctg cgc cgg gag caa gag gtg gca gag gag cgg aga aat gct ctc ttc       1793
Leu Arg Arg Glu Gln Glu Val Ala Glu Glu Arg Arg Asn Ala Leu Phe           
555                 560                 565                 570           

cca gag gtc ttc tcc cca acg cca gat gag aac tct gac cag aac tcc       1841
Pro Glu Val Phe Ser Pro Thr Pro Asp Glu Asn Ser Asp Gln Asn Ser           
                575                 580                 585               

agg agc tcc tcc cag gca tcc ggc atc acg ggc agt tac tcg gtg tct       1889
Arg Ser Ser Ser Gln Ala Ser Gly Ile Thr Gly Ser Tyr Ser Val Ser           
            590                 595                 600                   

gag tct ccc ttc ttc agc ccc atc cac cta cac tca aac gtg gcg tgg       1937
Glu Ser Pro Phe Phe Ser Pro Ile His Leu His Ser Asn Val Ala Trp           
        605                 610                 615                       

aca gtg gaa gat cca gtg gac agt gct cct ccc ggg cag aga aag aag       1985
Thr Val Glu Asp Pro Val Asp Ser Ala Pro Pro Gly Gln Arg Lys Lys           
    620                 625                 630                           

gag caa tgg tac gct ggc atc aac ccc tcg gac ggt atc aac tca gag       2033
Glu Gln Trp Tyr Ala Gly Ile Asn Pro Ser Asp Gly Ile Asn Ser Glu           
635                 640                 645                 650           

gtc ctg gaa gcc ata cgg gtg acc cgt cac aag aac gcc atg gca gag       2081
Val Leu Glu Ala Ile Arg Val Thr Arg His Lys Asn Ala Met Ala Glu           
                655                 660                 665               

cgc tgg gaa tcc cgc atc tac gcc agt gag gag gat gac tga               2123
Arg Trp Glu Ser Arg Ile Tyr Ala Ser Glu Glu Asp Asp                       
            670                 675                                       

gcctcgggat ggggcgccca ccccctgccc tgccctgacc ctcgtgggaa ctgccaagac     2183

catcgccaag cccccaccct aggaaatggg tcctaggtcc aggatccaag aaccacagct     2243

catctgccaa caatcccacc atgggcacat ttgggactgt tgggtttttc gtttccgttt     2303

ctatcttcct ttagaaatgt ttctgccttt ggggtctaaa gcttttgggg atgaaatggg     2363

acccctgctg attctttctg cttctaagac tttgccaaat gccctgggtc taagaaagaa     2423

agagacccgc tcctccactt tcaggtgtaa tttgcttccg ctagtctgag ggcagaggga     2483

ccggtcaaag agggtggcac agatcgcagc accttgaggg gctgcgggtc tgagggagga     2543

gacactcagc tcctccctct gagaagtccc aagctgagag gggagacctg cccctttcca     2603

accctgggaa accatccagt ctgagggagg aggccaaact cccagtgctg ggggtccctg     2663

tgcagccctc aaacccttca ccttggtgca cccagccaca cctggtggac acaaagctct     2723

cacatcgata ggatcccatg aggatggtcc ccttcacctg ggagaaaagt gacccagttt     2783

aggagctgga ggggggtctt tgtcccccac ccccaaactg ccctgaaata aacctggagt     2843

gagctgccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2903

aaaa                                                                  2907


<210>  394
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  394

Met Asp Arg Val Thr Arg Tyr Pro Ile Leu Gly Ile Pro Gln Ala His 
1               5                   10                  15      


Arg Gly Thr Gly Leu Val Leu Asp Gly Asp Thr Ser Tyr Thr Tyr His 
            20                  25                  30          


Leu Val Cys Met Gly Pro Glu Ala Ser Gly Trp Gly Gln Asp Glu Pro 
        35                  40                  45              


Gln Thr Trp Pro Thr Asp His Arg Ala Gln Gln Gly Val Gln Arg Gln 
    50                  55                  60                  


Gly Val Ser Tyr Ser Val His Ala Tyr Thr Gly Gln Pro Ser Pro Arg 
65                  70                  75                  80  


Gly Leu His Ser Glu Asn Arg Glu Asp Glu Gly Trp Gln Val Tyr Arg 
                85                  90                  95      


Leu Gly Ala Arg Asp Ala His Gln Gly Arg Pro Thr Trp Ala Leu Arg 
            100                 105                 110         


Pro Glu Asp Gly Glu Asp Lys Glu Met Lys Thr Tyr Arg Leu Asp Ala 
        115                 120                 125             


Gly Asp Ala Asp Pro Arg Arg Leu Cys Asp Leu Glu Arg Glu Arg Trp 
    130                 135                 140                 


Ala Val Ile Gln Gly Gln Ala Val Arg Lys Ser Ser Thr Val Ala Thr 
145                 150                 155                 160 


Leu Gln Gly Thr Pro Asp His Gly Asp Pro Arg Thr Pro Gly Pro Pro 
                165                 170                 175     


Arg Ser Thr Pro Leu Glu Glu Asn Val Val Asp Arg Glu Gln Ile Asp 
            180                 185                 190         


Phe Leu Ala Ala Arg Gln Gln Phe Leu Ser Leu Glu Gln Ala Asn Lys 
        195                 200                 205             


Gly Ala Pro His Ser Ser Pro Ala Arg Gly Thr Pro Ala Gly Thr Thr 
    210                 215                 220                 


Pro Gly Ala Ser Gln Ala Pro Lys Ala Phe Asn Lys Pro His Leu Ala 
225                 230                 235                 240 


Asn Gly His Val Val Pro Ile Lys Pro Gln Val Lys Gly Val Val Arg 
                245                 250                 255     


Glu Glu Asn Lys Val Arg Ala Val Pro Thr Trp Ala Ser Val Gln Val 
            260                 265                 270         


Val Asp Asp Pro Gly Ser Leu Ala Ser Val Glu Ser Pro Gly Thr Pro 
        275                 280                 285             


Lys Glu Thr Pro Ile Glu Arg Glu Ile Arg Leu Ala Gln Glu Arg Glu 
    290                 295                 300                 


Ala Asp Leu Arg Glu Gln Arg Gly Leu Arg Gln Ala Thr Asp His Gln 
305                 310                 315                 320 


Glu Leu Val Glu Ile Pro Thr Arg Pro Leu Leu Thr Lys Leu Ser Leu 
                325                 330                 335     


Ile Thr Ala Pro Arg Arg Glu Arg Gly Arg Pro Ser Leu Tyr Val Gln 
            340                 345                 350         


Arg Asp Ile Val Gln Glu Thr Gln Arg Glu Glu Asp His Arg Arg Glu 
        355                 360                 365             


Gly Leu His Val Gly Arg Ala Ser Thr Pro Asp Trp Val Ser Glu Gly 
    370                 375                 380                 


Pro Gln Pro Gly Leu Arg Arg Ala Leu Ser Ser Asp Ser Ile Leu Ser 
385                 390                 395                 400 


Pro Ala Pro Asp Ala Arg Ala Ala Asp Pro Ala Pro Glu Val Arg Lys 
                405                 410                 415     


Val Asn Arg Ile Pro Pro Asp Ala Tyr Gln Pro Tyr Leu Ser Pro Gly 
            420                 425                 430         


Thr Pro Gln Leu Glu Phe Ser Ala Phe Gly Ala Phe Gly Lys Pro Ser 
        435                 440                 445             


Ser Leu Ser Thr Ala Glu Ala Lys Ala Ala Thr Ser Pro Lys Ala Thr 
    450                 455                 460                 


Met Ser Pro Arg His Leu Ser Glu Ser Ser Gly Lys Pro Leu Ser Thr 
465                 470                 475                 480 


Lys Gln Glu Ala Ser Lys Pro Pro Arg Gly Cys Pro Gln Ala Asn Arg 
                485                 490                 495     


Gly Val Val Arg Trp Glu Tyr Phe Arg Leu Arg Pro Leu Arg Phe Arg 
            500                 505                 510         


Ala Pro Asp Glu Pro Gln Gln Ala Gln Val Pro His Val Trp Gly Trp 
        515                 520                 525             


Glu Val Ala Gly Ala Pro Ala Leu Arg Leu Gln Lys Ser Gln Ser Ser 
    530                 535                 540                 


Asp Leu Leu Glu Arg Glu Arg Glu Ser Val Leu Arg Arg Glu Gln Glu 
545                 550                 555                 560 


Val Ala Glu Glu Arg Arg Asn Ala Leu Phe Pro Glu Val Phe Ser Pro 
                565                 570                 575     


Thr Pro Asp Glu Asn Ser Asp Gln Asn Ser Arg Ser Ser Ser Gln Ala 
            580                 585                 590         


Ser Gly Ile Thr Gly Ser Tyr Ser Val Ser Glu Ser Pro Phe Phe Ser 
        595                 600                 605             


Pro Ile His Leu His Ser Asn Val Ala Trp Thr Val Glu Asp Pro Val 
    610                 615                 620                 


Asp Ser Ala Pro Pro Gly Gln Arg Lys Lys Glu Gln Trp Tyr Ala Gly 
625                 630                 635                 640 


Ile Asn Pro Ser Asp Gly Ile Asn Ser Glu Val Leu Glu Ala Ile Arg 
                645                 650                 655     


Val Thr Arg His Lys Asn Ala Met Ala Glu Arg Trp Glu Ser Arg Ile 
            660                 665                 670         


Tyr Ala Ser Glu Glu Asp Asp 
        675                 


<210>  395
<211>  6629
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (314)..(2506)

<400>  395
gctgcggccg cggctgaggg acctgcccgc gctgctgcgg agcgggctca cgctgcggag       60

gaagcggagc gccgctgggg gccggactct atcaagaaga atatctaatc cgtaccttga      120

acatacgcct tcccagattt atggagagaa ttcttcttgt gcaggaagag cattgaggaa      180

tattattatc gttcaagcag ctgacctgat aaaggacaga gtgaacctca aggggtttta      240

caggaggagc tgcgttgggt cagagctggt agactggctt ctagaacact gtcctttcgt      300

ccagtgcaga tct atg gcc ata gga gtc tgg caa ctc cta ctg gac atg         349
               Met Ala Ile Gly Val Trp Gln Leu Leu Leu Asp Met            
               1               5                   10                     

gga att atg tta tca gtg gac cag cat cta tac ttt caa gat act tat        397
Gly Ile Met Leu Ser Val Asp Gln His Leu Tyr Phe Gln Asp Thr Tyr           
        15                  20                  25                        

gtt ttc tac cag ttt tcc tct gat gaa tgt agc tac ttg tac tgt gaa        445
Val Phe Tyr Gln Phe Ser Ser Asp Glu Cys Ser Tyr Leu Tyr Cys Glu           
    30                  35                  40                            

ttt gaa aga gaa gaa gaa tgg caa aat ggt gtc aag ctt tta ctg caa        493
Phe Glu Arg Glu Glu Glu Trp Gln Asn Gly Val Lys Leu Leu Leu Gln           
45                  50                  55                  60            

ctt gtg cct ctc att cct gcc aga ggt ggc atc tgt gaa ctg tct cat        541
Leu Val Pro Leu Ile Pro Ala Arg Gly Gly Ile Cys Glu Leu Ser His           
                65                  70                  75                

cag aaa att gaa gac tcc gaa gaa agc agt gat gaa att ctt gtg cgt        589
Gln Lys Ile Glu Asp Ser Glu Glu Ser Ser Asp Glu Ile Leu Val Arg           
            80                  85                  90                    

cta aca tct gcg gtg cag aga gag cta gca gct gtt att gct ttg aaa        637
Leu Thr Ser Ala Val Gln Arg Glu Leu Ala Ala Val Ile Ala Leu Lys           
        95                  100                 105                       

gca agg aag tct gca att gaa caa gat gaa gaa aac aac gac aaa cat        685
Ala Arg Lys Ser Ala Ile Glu Gln Asp Glu Glu Asn Asn Asp Lys His           
    110                 115                 120                           

gta gct gta aca gaa gcc gaa agt gtt cca gat tct cag gca ggg gtg        733
Val Ala Val Thr Glu Ala Glu Ser Val Pro Asp Ser Gln Ala Gly Val           
125                 130                 135                 140           

atg tgc aag ctc cag gaa aga gat gaa atc gga cga att gaa cta gtc        781
Met Cys Lys Leu Gln Glu Arg Asp Glu Ile Gly Arg Ile Glu Leu Val           
                145                 150                 155               

cag aag ctg gca aaa gaa aac tat cag ttt ttg cag acg gac aaa aaa        829
Gln Lys Leu Ala Lys Glu Asn Tyr Gln Phe Leu Gln Thr Asp Lys Lys           
            160                 165                 170                   

gaa cag gag aag tct gaa cac caa gat gat gaa gtg acg act gtt cag        877
Glu Gln Glu Lys Ser Glu His Gln Asp Asp Glu Val Thr Thr Val Gln           
        175                 180                 185                       

gtt aaa gag caa gac cag agc gtc ctg gtg ctg aag aaa gtg cag tgc        925
Val Lys Glu Gln Asp Gln Ser Val Leu Val Leu Lys Lys Val Gln Cys           
    190                 195                 200                           

tgt ggc cca gcc ccc aca gct ggg agt gcg gag agc cat tgg aga tat        973
Cys Gly Pro Ala Pro Thr Ala Gly Ser Ala Glu Ser His Trp Arg Tyr           
205                 210                 215                 220           

gtg gtg gtg tcc ggg acc ccg gag aag att ttg gag cac ctt ttg aat       1021
Val Val Val Ser Gly Thr Pro Glu Lys Ile Leu Glu His Leu Leu Asn           
                225                 230                 235               

gac ttg cac ctg gaa gaa gtc cag gac aaa gaa aca gag acc ctc ctg       1069
Asp Leu His Leu Glu Glu Val Gln Asp Lys Glu Thr Glu Thr Leu Leu           
            240                 245                 250                   

gat gac ttc ctt ctc acg tac act gtc ttc atg aca act gat gac ttg       1117
Asp Asp Phe Leu Leu Thr Tyr Thr Val Phe Met Thr Thr Asp Asp Leu           
        255                 260                 265                       

tgc cag gct ctg tta agg cac tat tct gct aag aag tat caa ggc aaa       1165
Cys Gln Ala Leu Leu Arg His Tyr Ser Ala Lys Lys Tyr Gln Gly Lys           
    270                 275                 280                           

gag gaa aac tca gac gtt ccg cgt agg aaa cgt aaa gtc ttg cat ctt       1213
Glu Glu Asn Ser Asp Val Pro Arg Arg Lys Arg Lys Val Leu His Leu           
285                 290                 295                 300           

gtt tcc cag tgg att gct ctg tac aaa gac tgg tta cct gaa gat gaa       1261
Val Ser Gln Trp Ile Ala Leu Tyr Lys Asp Trp Leu Pro Glu Asp Glu           
                305                 310                 315               

cat tca aaa atg ttt tta aag acc ata tat agg aat gta ctg gat gat       1309
His Ser Lys Met Phe Leu Lys Thr Ile Tyr Arg Asn Val Leu Asp Asp           
            320                 325                 330                   

gtt tat gaa tat cca ata ctt gaa aaa gaa ttg aaa gaa ttt caa aag       1357
Val Tyr Glu Tyr Pro Ile Leu Glu Lys Glu Leu Lys Glu Phe Gln Lys           
        335                 340                 345                       

ata ctt gga atg cac cgt cgt cac act gta gat gaa tat tca cca caa       1405
Ile Leu Gly Met His Arg Arg His Thr Val Asp Glu Tyr Ser Pro Gln           
    350                 355                 360                           

aaa aag aat aaa gcc ctt ttc cac caa ttc agt ctt aag gag aac tgg       1453
Lys Lys Asn Lys Ala Leu Phe His Gln Phe Ser Leu Lys Glu Asn Trp           
365                 370                 375                 380           

ctc cag cat aga gga act gtg act gaa acg gag gaa att ttc tgc cac       1501
Leu Gln His Arg Gly Thr Val Thr Glu Thr Glu Glu Ile Phe Cys His           
                385                 390                 395               

gtg tat ata aca gag cac tcc tat gtc agt gtg aag gca aaa gtt tcc       1549
Val Tyr Ile Thr Glu His Ser Tyr Val Ser Val Lys Ala Lys Val Ser           
            400                 405                 410                   

agt ata gcc caa gag atc cta aaa gtc gtg gca gaa aag atc cag tat       1597
Ser Ile Ala Gln Glu Ile Leu Lys Val Val Ala Glu Lys Ile Gln Tyr           
        415                 420                 425                       

gca gaa gag gat ctg gct ctg gtg gcc atc aca ttc tct ggg gaa aag       1645
Ala Glu Glu Asp Leu Ala Leu Val Ala Ile Thr Phe Ser Gly Glu Lys           
    430                 435                 440                           

cat gaa ctt cag cca aat gac tta gtc atc tcc aaa tcc ctc gag gca       1693
His Glu Leu Gln Pro Asn Asp Leu Val Ile Ser Lys Ser Leu Glu Ala           
445                 450                 455                 460           

tct ggt cga ata tat gtc tac cgg aaa gac ctg gcg gac act ttg aac       1741
Ser Gly Arg Ile Tyr Val Tyr Arg Lys Asp Leu Ala Asp Thr Leu Asn           
                465                 470                 475               

cca ttt gca gaa aat gag gaa tca cag caa agg tcg atg agg att ttg       1789
Pro Phe Ala Glu Asn Glu Glu Ser Gln Gln Arg Ser Met Arg Ile Leu           
            480                 485                 490                   

gga atg aac act tgg gat ctt gct ctg gaa tta atg aat ttt gat tgg       1837
Gly Met Asn Thr Trp Asp Leu Ala Leu Glu Leu Met Asn Phe Asp Trp           
        495                 500                 505                       

agt cta ttc aat tca att cac gag caa gag ctg atc tac ttc acg ttc       1885
Ser Leu Phe Asn Ser Ile His Glu Gln Glu Leu Ile Tyr Phe Thr Phe           
    510                 515                 520                           

agc aga cag gga agt ggg gaa cac act gca aat ctc agc ctt ctg ctc       1933
Ser Arg Gln Gly Ser Gly Glu His Thr Ala Asn Leu Ser Leu Leu Leu           
525                 530                 535                 540           

cag aga tgc aat gag gtc cag ctt tgg gtg gcc acg gag att ctg ctc       1981
Gln Arg Cys Asn Glu Val Gln Leu Trp Val Ala Thr Glu Ile Leu Leu           
                545                 550                 555               

tgc agc cag ctg ggc aag cga gtg cag ctg gtg aaa aaa ttc atc aaa       2029
Cys Ser Gln Leu Gly Lys Arg Val Gln Leu Val Lys Lys Phe Ile Lys           
            560                 565                 570                   

att gcg gct cac tgc aaa gcc cag aga aac ctg aat tct ttc ttt gcc       2077
Ile Ala Ala His Cys Lys Ala Gln Arg Asn Leu Asn Ser Phe Phe Ala           
        575                 580                 585                       

att gtg atg ggt ctc aac act gct tct gtc agt cga ctg tcg cag acc       2125
Ile Val Met Gly Leu Asn Thr Ala Ser Val Ser Arg Leu Ser Gln Thr           
    590                 595                 600                           

tgg gag aaa atc cct ggg aag ttt aag aaa ctt ttc tct gaa ctt gaa       2173
Trp Glu Lys Ile Pro Gly Lys Phe Lys Lys Leu Phe Ser Glu Leu Glu           
605                 610                 615                 620           

agt tta aca gat cct tcc cta aat cac aaa gcc tac aga gat gca ttc       2221
Ser Leu Thr Asp Pro Ser Leu Asn His Lys Ala Tyr Arg Asp Ala Phe           
                625                 630                 635               

aaa aag atg aag cca cca aaa atc cct ttc atg ccc tta ttg ctt aaa       2269
Lys Lys Met Lys Pro Pro Lys Ile Pro Phe Met Pro Leu Leu Leu Lys           
            640                 645                 650                   

gat gta aca ttt att cat gaa gga aat aaa act ttt ttg gat aat ctt       2317
Asp Val Thr Phe Ile His Glu Gly Asn Lys Thr Phe Leu Asp Asn Leu           
        655                 660                 665                       

gtc aat ttt gaa aag ctg cat atg atc gca gac act gtc cga acc ctg       2365
Val Asn Phe Glu Lys Leu His Met Ile Ala Asp Thr Val Arg Thr Leu           
    670                 675                 680                           

aga cac tgc agg act aac cag ttt ggt gac ctg tct cca aaa gag cat       2413
Arg His Cys Arg Thr Asn Gln Phe Gly Asp Leu Ser Pro Lys Glu His           
685                 690                 695                 700           

caa gag tta aag tcc tat gtt aat cac ctg tat gtc att gac agc cag       2461
Gln Glu Leu Lys Ser Tyr Val Asn His Leu Tyr Val Ile Asp Ser Gln           
                705                 710                 715               

cag gct ctg ttt gag ctc tca cac agg atc gag cct cgg gtg tga           2506
Gln Ala Leu Phe Glu Leu Ser His Arg Ile Glu Pro Arg Val                   
            720                 725                 730                   

gccccactgc ctcacctccc ctgtatctgc agcactttga gctacgggaa tgtctatgcc     2566

aagcacgttg ctttcctgtg agaaaagaag ttgctgagtt ttatcagtat aacccaagac     2626

attcacagga aagccagcca aagcgtgttc aggaagtgat gtcagccacc agagaggggg     2686

agaggtttct ccatgctact ctcgggacaa gaaggcagaa ggagagtcag aagcattctt     2746

gagatggaga aggctggttt cttatgatca cattgttgat ccagtccagt tttcaatatg     2806

agatgtgcca gcatcaagac aagacaacgt cttgacatgc aatgaccaaa tatttcatta     2866

agagcgtgca tgaaacagga aggagttttt actttgccta gttttagatt actgtccata     2926

agctgtcaaa gaagtcattc ttttgaacac ctgatgacag agacagcatc tctagatctc     2986

cagggaggag aggtttctgt tgatacaacc tgtgacatca ccaaaagcca cttgtgtcta     3046

gggagttagt gaggactgca gctagcatcc atgctctgat gggcagatga acaatgtcaa     3106

ggtgtgcatc actttgcacc acaatcaact attgacacat gcttgcaggt gaaattagtt     3166

tctgtacaac tgatttgcag ctataggcaa ggtagatgaa gttgctttgc cagtaaggaa     3226

aaatagtaat ctttaagaaa ttgactcatt gtttaatttc tggggatttt ctttatactt     3286

ctaagcaggc tcttatcttt tattggacat aatatgattt tgaaaaagca cagtgcctga     3346

cacattgcaa acactcacca actgcttgct gaggtgacag agtcacaaaa gtctgcattc     3406

ttgtgcctga tgatgcattt tgcgtacctc atacaggctc cttgcccaca ctatggaatg     3466

acagcagcca gtgcagggag gttaagtgac atttaatgag tgaagcactt agcactctct     3526

aggtaataag atagtggtaa ttactagtgt tttggcaaat gaaaaatgcc ctgaaatagc     3586

caaatgtctg attaatgttg gcaacttaga agtcctataa tccaactacc agccaaagca     3646

gggagccttt ctataatttg cctttttttt tttttttttc aaaatctgag tcttctaaaa     3706

tcttattatt cccattttta ccaattgagg ctcctgtagc aaataagacc tcttgatatt     3766

ttcaaggact ggttagagga tttctttcaa ccttcacatg aacaaaacag cctatgggtc     3826

aaaataatga aatccacccc tgcctgctag atacttgtca ccttgctaaa atgcaagggc     3886

ctggtccatt cattttccaa atgcaggagt cttggtgcac ttctcactct tcctgcctgt     3946

tcatctcttt catgcccaca cagacctgtt tcctttttgt ctcatcaacg cctcattcat     4006

cctcattact gaggcgtgtc caatgctttt tgacatcttt atagcagtgc tgtttcctgg     4066

gctcaggaac cacactgagc ttgagatact gctggaagga accatgtgga gagaaggttt     4126

gggagaactt tgagagagac ttagtttggc ccagcatgta aaacttcagt cctgaacatt     4186

tatagggttt tatagaaggg catcctccag ggctggtcca ttcagagaaa tgctgcatgc     4246

tgccgtcatg gaatgtggcc cacaggacac cagagccgtg agaaccggag agcagacttc     4306

cctcacggct gggctgagca aaccctccaa agccctcctc acgcagttac taacaatagc     4366

atgggcttac agcacaagca cgtgttctca cctttttcct atgccctgga ctaaggtttg     4426

gccagtgtaa tcatataagg ccatcctgac attgtttctg tgtttcaaaa tttggatttt     4486

tatttacatt agaactacat tgctcctagt agaacattac ctttagggga ctaattttcc     4546

atggagaact atttcagcat attgcatgct gctcagaccc caagtcagat atgcccacca     4606

agccagatga agctacacaa atgtggtatt taaatgcatt ttgtacagtg acttcagagt     4666

atctcacatg acatgggtgt aaactggctg gggagaaaat gatgcttgtt cacctcttcc     4726

tccagccgtg gttaggtggt cctaggggta gcagagggaa gggaggattt tgtgcagtca     4786

agatttgctt ttccatcctt gtcttctgaa tgtctaaaat ctctgcatct ttctgaagtt     4846

taacaactgt ctccagaggt ttgccaggca gcagctctca gaagtttcca aagctttgca     4906

gaatcttaga tctggaatta aagaattcaa gcccgaattg tgagaaccag atattactca     4966

acagaaagct ctttctaagg aatctgagct gttcactggt ggacagtggt ggggcttgag     5026

tgctccttgt taataggatg ggccatgcac cctctctgga tattcaccaa ggcctcttca     5086

gaatagggtt tgttctggct agaagcgtgg tctagaagat ggctaagctc tttgccagct     5146

ctcatttgga gttttattat tgcataaaat cttcgctcac tctgcaaatc ttacgtaatc     5206

tggcaccttc ggcaccaggt ggtgcagggg cacttctaag tgggctcttt ttgttacagc     5266

acaactctca gacagtcctg tgggtctttg gattcgtcag cattccagca aactagccct     5326

gcttagaagt tagcacaaga cagcagaatg caggaccccg taggcaaaat cacaaccttg     5386

ctattaaaaa aaattttgtt ttacatacac atttgcaggt gttccctaga gtgtggtgtt     5446

ttgaatttgc tctttgtcat ctgtataatt gccaaatgat tatagtgata cacatgacct     5506

gcattcactt ttttctagtt tccttaatta tgtttagaat aaattcattt ccctagaccg     5566

agaaccacaa acaggtagtg tggagcatac accgaattta gaagcatgtg gataaggtca     5626

gtgctcacac tgcctagtcc acagggagag gatgctgcat gaatatatac ttgcctctga     5686

gtggaggaga aatcgtggca tgaaagagag agtaccagtg atgacttctt atccctggag     5746

ctgggctttc actgctaccc atatcccagc cctgcgagtc tgttctagcc agcacagaca     5806

ccgcagatcc ggaactgaat gttcctaaat ggcgcagcca atccaggctt ttcagaaact     5866

gggcaaaaac attaaaatgg ggacgatcgg gtcttccgca gtggtccaac acaggatttc     5926

ttttaaatgt ttcaaaaaca tgtccttaaa atttcagcct gcttcttagc gagtgggcca     5986

gttttgctta aaactggtgg gggggcgggg gggaagtttt taaaaattgc caaaaagtta     6046

gatgcaaatg tattactgta taaagcaaag ctgtatatac taaacatttt ttagcagagt     6106

aatatttatt tgcatagtct atttattgta ttcgtatcac actgttatta aatactggga     6166

tgaaatcagt gacctgaagc aagaaatctt gccttttaat gtatcattaa ttagggctgc     6226

tgtgatattg tcagcttgca ttaacaatta gaagatagag aacccgccat cagggtgtct     6286

acctaacttc tcagggacta cacttggtag ttttccacca tttaaagaac tggtaaatat     6346

gaaacatttg ttgagttacc agaattgcca ttaacagtgt tttctttccc atattccatg     6406

ctttctgcct ctgtgtatat atataatata tatgtatatg actgtgctgt gtatttatcg     6466

aagctagtaa gcaataattt atatgtaaaa atggccaagc aatataaggt taaaacttat     6526

ataagtaacc cttaccttat cttgtatttt caattttttt ttaaaactgc ttttccaaat     6586

atgagactat gttaaagaca ctattcatgc ctcttaaaaa aaa                       6629


<210>  396
<211>  730
<212>  PRT
<213>  Homo sapiens

<400>  396

Met Ala Ile Gly Val Trp Gln Leu Leu Leu Asp Met Gly Ile Met Leu 
1               5                   10                  15      


Ser Val Asp Gln His Leu Tyr Phe Gln Asp Thr Tyr Val Phe Tyr Gln 
            20                  25                  30          


Phe Ser Ser Asp Glu Cys Ser Tyr Leu Tyr Cys Glu Phe Glu Arg Glu 
        35                  40                  45              


Glu Glu Trp Gln Asn Gly Val Lys Leu Leu Leu Gln Leu Val Pro Leu 
    50                  55                  60                  


Ile Pro Ala Arg Gly Gly Ile Cys Glu Leu Ser His Gln Lys Ile Glu 
65                  70                  75                  80  


Asp Ser Glu Glu Ser Ser Asp Glu Ile Leu Val Arg Leu Thr Ser Ala 
                85                  90                  95      


Val Gln Arg Glu Leu Ala Ala Val Ile Ala Leu Lys Ala Arg Lys Ser 
            100                 105                 110         


Ala Ile Glu Gln Asp Glu Glu Asn Asn Asp Lys His Val Ala Val Thr 
        115                 120                 125             


Glu Ala Glu Ser Val Pro Asp Ser Gln Ala Gly Val Met Cys Lys Leu 
    130                 135                 140                 


Gln Glu Arg Asp Glu Ile Gly Arg Ile Glu Leu Val Gln Lys Leu Ala 
145                 150                 155                 160 


Lys Glu Asn Tyr Gln Phe Leu Gln Thr Asp Lys Lys Glu Gln Glu Lys 
                165                 170                 175     


Ser Glu His Gln Asp Asp Glu Val Thr Thr Val Gln Val Lys Glu Gln 
            180                 185                 190         


Asp Gln Ser Val Leu Val Leu Lys Lys Val Gln Cys Cys Gly Pro Ala 
        195                 200                 205             


Pro Thr Ala Gly Ser Ala Glu Ser His Trp Arg Tyr Val Val Val Ser 
    210                 215                 220                 


Gly Thr Pro Glu Lys Ile Leu Glu His Leu Leu Asn Asp Leu His Leu 
225                 230                 235                 240 


Glu Glu Val Gln Asp Lys Glu Thr Glu Thr Leu Leu Asp Asp Phe Leu 
                245                 250                 255     


Leu Thr Tyr Thr Val Phe Met Thr Thr Asp Asp Leu Cys Gln Ala Leu 
            260                 265                 270         


Leu Arg His Tyr Ser Ala Lys Lys Tyr Gln Gly Lys Glu Glu Asn Ser 
        275                 280                 285             


Asp Val Pro Arg Arg Lys Arg Lys Val Leu His Leu Val Ser Gln Trp 
    290                 295                 300                 


Ile Ala Leu Tyr Lys Asp Trp Leu Pro Glu Asp Glu His Ser Lys Met 
305                 310                 315                 320 


Phe Leu Lys Thr Ile Tyr Arg Asn Val Leu Asp Asp Val Tyr Glu Tyr 
                325                 330                 335     


Pro Ile Leu Glu Lys Glu Leu Lys Glu Phe Gln Lys Ile Leu Gly Met 
            340                 345                 350         


His Arg Arg His Thr Val Asp Glu Tyr Ser Pro Gln Lys Lys Asn Lys 
        355                 360                 365             


Ala Leu Phe His Gln Phe Ser Leu Lys Glu Asn Trp Leu Gln His Arg 
    370                 375                 380                 


Gly Thr Val Thr Glu Thr Glu Glu Ile Phe Cys His Val Tyr Ile Thr 
385                 390                 395                 400 


Glu His Ser Tyr Val Ser Val Lys Ala Lys Val Ser Ser Ile Ala Gln 
                405                 410                 415     


Glu Ile Leu Lys Val Val Ala Glu Lys Ile Gln Tyr Ala Glu Glu Asp 
            420                 425                 430         


Leu Ala Leu Val Ala Ile Thr Phe Ser Gly Glu Lys His Glu Leu Gln 
        435                 440                 445             


Pro Asn Asp Leu Val Ile Ser Lys Ser Leu Glu Ala Ser Gly Arg Ile 
    450                 455                 460                 


Tyr Val Tyr Arg Lys Asp Leu Ala Asp Thr Leu Asn Pro Phe Ala Glu 
465                 470                 475                 480 


Asn Glu Glu Ser Gln Gln Arg Ser Met Arg Ile Leu Gly Met Asn Thr 
                485                 490                 495     


Trp Asp Leu Ala Leu Glu Leu Met Asn Phe Asp Trp Ser Leu Phe Asn 
            500                 505                 510         


Ser Ile His Glu Gln Glu Leu Ile Tyr Phe Thr Phe Ser Arg Gln Gly 
        515                 520                 525             


Ser Gly Glu His Thr Ala Asn Leu Ser Leu Leu Leu Gln Arg Cys Asn 
    530                 535                 540                 


Glu Val Gln Leu Trp Val Ala Thr Glu Ile Leu Leu Cys Ser Gln Leu 
545                 550                 555                 560 


Gly Lys Arg Val Gln Leu Val Lys Lys Phe Ile Lys Ile Ala Ala His 
                565                 570                 575     


Cys Lys Ala Gln Arg Asn Leu Asn Ser Phe Phe Ala Ile Val Met Gly 
            580                 585                 590         


Leu Asn Thr Ala Ser Val Ser Arg Leu Ser Gln Thr Trp Glu Lys Ile 
        595                 600                 605             


Pro Gly Lys Phe Lys Lys Leu Phe Ser Glu Leu Glu Ser Leu Thr Asp 
    610                 615                 620                 


Pro Ser Leu Asn His Lys Ala Tyr Arg Asp Ala Phe Lys Lys Met Lys 
625                 630                 635                 640 


Pro Pro Lys Ile Pro Phe Met Pro Leu Leu Leu Lys Asp Val Thr Phe 
                645                 650                 655     


Ile His Glu Gly Asn Lys Thr Phe Leu Asp Asn Leu Val Asn Phe Glu 
            660                 665                 670         


Lys Leu His Met Ile Ala Asp Thr Val Arg Thr Leu Arg His Cys Arg 
        675                 680                 685             


Thr Asn Gln Phe Gly Asp Leu Ser Pro Lys Glu His Gln Glu Leu Lys 
    690                 695                 700                 


Ser Tyr Val Asn His Leu Tyr Val Ile Asp Ser Gln Gln Ala Leu Phe 
705                 710                 715                 720 


Glu Leu Ser His Arg Ile Glu Pro Arg Val 
                725                 730 


<210>  397
<211>  1212
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (95)..(613)

<400>  397
ggagtccaga cccgacggcc ggcccagttc cacgcaccca gcgagcccaa gcgccttctc       60

cgcaccaggg aagccccacc caccagaagc caag atg tcc agc aag cgg gcc aaa      115
                                      Met Ser Ser Lys Arg Ala Lys         
                                      1               5                   

gcc aag acc acc aag aag cgg cca cag cgg gcc aca tcc aat gtc ttc        163
Ala Lys Thr Thr Lys Lys Arg Pro Gln Arg Ala Thr Ser Asn Val Phe           
        10                  15                  20                        

gca atg ttt gac cag tcc cag atc cag gag ttt aag gag gct ttc aac        211
Ala Met Phe Asp Gln Ser Gln Ile Gln Glu Phe Lys Glu Ala Phe Asn           
    25                  30                  35                            

atg att gac cag aac cgt gat ggc ttc att gac aag gag gac ctg cac        259
Met Ile Asp Gln Asn Arg Asp Gly Phe Ile Asp Lys Glu Asp Leu His           
40                  45                  50                  55            

gac atg ctg gcc tcg ctg ggg aag aac ccc aca gac gaa tac ctg gag        307
Asp Met Leu Ala Ser Leu Gly Lys Asn Pro Thr Asp Glu Tyr Leu Glu           
                60                  65                  70                

ggc atg atg agc gag gcc ccg ggg ccc atc aac ttc acc atg ttc ctc        355
Gly Met Met Ser Glu Ala Pro Gly Pro Ile Asn Phe Thr Met Phe Leu           
            75                  80                  85                    

acc atg ttt ggg gag aag ctg aac ggc acg gac ccc gag gat gtg att        403
Thr Met Phe Gly Glu Lys Leu Asn Gly Thr Asp Pro Glu Asp Val Ile           
        90                  95                  100                       

cgc aac gcc ttt gcc tgc ttc gac gag gaa gcc tca ggt ttc atc cat        451
Arg Asn Ala Phe Ala Cys Phe Asp Glu Glu Ala Ser Gly Phe Ile His           
    105                 110                 115                           

gag gac cac ctc cgg gag ctg ctc acc acc atg ggt gac cgc ttc aca        499
Glu Asp His Leu Arg Glu Leu Leu Thr Thr Met Gly Asp Arg Phe Thr           
120                 125                 130                 135           

gat gag gaa gtg gac gag atg tac cgg gag gca ccc att gat aag aaa        547
Asp Glu Glu Val Asp Glu Met Tyr Arg Glu Ala Pro Ile Asp Lys Lys           
                140                 145                 150               

ggc aac ttc aac tac gtg gag ttc acc cgc atc ctc aaa cat ggc gcc        595
Gly Asn Phe Asn Tyr Val Glu Phe Thr Arg Ile Leu Lys His Gly Ala           
            155                 160                 165                   

aag gat aaa gac gac tag gccaccccag ccccctgaca ccccagcccc               643
Lys Asp Lys Asp Asp                                                       
        170                                                               

cgccagtcac ccctccccgc acacacccgt ccataccagc tccctgccca tgaccctcgc      703

tcagggatcc ccctttgagg ggttagggtc ccagttccca gtggaagaaa caggccagga      763

gaagtgcgtg ccgagctgag gcagatgttc ccacagtgac cccagagccc tgggctatag      823

tctctgaccc ctccaaggaa agaccacctt ctggggacat gggctggagg gcaggaccta      883

gaggcaccaa gggaaggccc cattccgggg ctgttccccg aggaggaagg gaaggggctc      943

tgtgtgcccc ccaggaggaa gaggccctga gtcctgggat cagacacccc ttcacgtgta     1003

tccccacaca aatgcaagct caccaaggtc ccctctcagt ccccttccct acaccctgac     1063

cggccactgc cgcacaccca cccagagcac gccacccgcc atgggagtgt gctcaggagt     1123

cgcgggcagc gtggacatct gtcccagagg gggcagaatc tccaatagag gactgagcac     1183

tgctaaaaaa aaaaaaaaaa aaaaaaaaa                                       1212


<210>  398
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  398

Met Ser Ser Lys Arg Ala Lys Ala Lys Thr Thr Lys Lys Arg Pro Gln 
1               5                   10                  15      


Arg Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln 
            20                  25                  30          


Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe 
        35                  40                  45              


Ile Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn 
    50                  55                  60                  


Pro Thr Asp Glu Tyr Leu Glu Gly Met Met Ser Glu Ala Pro Gly Pro 
65                  70                  75                  80  


Ile Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly 
                85                  90                  95      


Thr Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu 
            100                 105                 110         


Glu Ala Ser Gly Phe Ile His Glu Asp His Leu Arg Glu Leu Leu Thr 
        115                 120                 125             


Thr Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Met Tyr Arg 
    130                 135                 140                 


Glu Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Val Glu Phe Thr 
145                 150                 155                 160 


Arg Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
                165                 170         


<210>  399
<211>  8189
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (84)..(2453)

<400>  399
gcggcggcgg ccaaactccg cggcgtcccc agggcgccag cttcgccctc gccgccgcgg       60

ccgcgctgct cttcggctcc gac atg gaa gat gga cct tct aat aat gcg agc      113
                          Met Glu Asp Gly Pro Ser Asn Asn Ala Ser         
                          1               5                   10          

tgc ttc cga agg ctg acc gag tgc ttc ctg agc ccc agt ttg aca gat        161
Cys Phe Arg Arg Leu Thr Glu Cys Phe Leu Ser Pro Ser Leu Thr Asp           
                15                  20                  25                

gaa aaa gtg aag gca tat ctt tct ctt cac ccc cag gta tta gat gaa        209
Glu Lys Val Lys Ala Tyr Leu Ser Leu His Pro Gln Val Leu Asp Glu           
            30                  35                  40                    

ttt gta tct gaa agt gtt agt gca gag aca gta gag aaa tgg ctg aag        257
Phe Val Ser Glu Ser Val Ser Ala Glu Thr Val Glu Lys Trp Leu Lys           
        45                  50                  55                        

agg aag aac aac aaa tca gaa gat gaa tca gct cct aag gaa gtc agc        305
Arg Lys Asn Asn Lys Ser Glu Asp Glu Ser Ala Pro Lys Glu Val Ser           
    60                  65                  70                            

agg tac caa gat acg aat atg cag gga gtt gta tat gaa cta aac agc        353
Arg Tyr Gln Asp Thr Asn Met Gln Gly Val Val Tyr Glu Leu Asn Ser           
75                  80                  85                  90            

tat ata gaa caa cgg ttg gac aca gga gga gac aac cag cta ctc ctc        401
Tyr Ile Glu Gln Arg Leu Asp Thr Gly Gly Asp Asn Gln Leu Leu Leu           
                95                  100                 105               

tat gaa ctg agc agc atc att aaa ata gcc aca aaa gcc gat gga ttt        449
Tyr Glu Leu Ser Ser Ile Ile Lys Ile Ala Thr Lys Ala Asp Gly Phe           
            110                 115                 120                   

gca ctg tat ttc ctt gga gag tgc aat aat agc ctg tgt ata ttc acg        497
Ala Leu Tyr Phe Leu Gly Glu Cys Asn Asn Ser Leu Cys Ile Phe Thr           
        125                 130                 135                       

cca cct ggg ata aag gaa gga aaa ccc cgc ctc atc cct gct ggg ccc        545
Pro Pro Gly Ile Lys Glu Gly Lys Pro Arg Leu Ile Pro Ala Gly Pro           
    140                 145                 150                           

atc act cag ggc acc acc gtc tct gct tat gtg gcc aag tcc agg aaa        593
Ile Thr Gln Gly Thr Thr Val Ser Ala Tyr Val Ala Lys Ser Arg Lys           
155                 160                 165                 170           

aca ctg cta gta gaa gac atc ctt gga gat gaa cga ttt cca aga ggt        641
Thr Leu Leu Val Glu Asp Ile Leu Gly Asp Glu Arg Phe Pro Arg Gly           
                175                 180                 185               

act gga ctg gaa tca ggg act cgt atc cag tct gtt ctt tgc tta cca        689
Thr Gly Leu Glu Ser Gly Thr Arg Ile Gln Ser Val Leu Cys Leu Pro           
            190                 195                 200                   

att gtc act gca att ggt gac ttg att ggt att ctc gag ctg tat cgg        737
Ile Val Thr Ala Ile Gly Asp Leu Ile Gly Ile Leu Glu Leu Tyr Arg           
        205                 210                 215                       

cac tgg ggc aaa gaa gcc ttc tgt ctt agt cac cag gag gtt gca aca        785
His Trp Gly Lys Glu Ala Phe Cys Leu Ser His Gln Glu Val Ala Thr           
    220                 225                 230                           

gca aat ctt gcc tgg gct tca gta gca ata cat cag gtg cag gta tgc        833
Ala Asn Leu Ala Trp Ala Ser Val Ala Ile His Gln Val Gln Val Cys           
235                 240                 245                 250           

aga ggc ctt gcc aaa cag aca gaa ttg aat gac ttc cta ctc gac gta        881
Arg Gly Leu Ala Lys Gln Thr Glu Leu Asn Asp Phe Leu Leu Asp Val           
                255                 260                 265               

tca aaa aca tat ttt gat aac ata gtt gca ata gat tct cta ctt gaa        929
Ser Lys Thr Tyr Phe Asp Asn Ile Val Ala Ile Asp Ser Leu Leu Glu           
            270                 275                 280                   

cac ata atg ata tat gca aaa aac ctg gtg aat gcc gat cgt tgt gcg        977
His Ile Met Ile Tyr Ala Lys Asn Leu Val Asn Ala Asp Arg Cys Ala           
        285                 290                 295                       

ctt ttc cag gtg gac cat aag aac aag gag tta tat tca gac ctt ttt       1025
Leu Phe Gln Val Asp His Lys Asn Lys Glu Leu Tyr Ser Asp Leu Phe           
    300                 305                 310                           

gat att gga gag gaa aag gaa gga aaa cct gtc ttc aag aag acc aaa       1073
Asp Ile Gly Glu Glu Lys Glu Gly Lys Pro Val Phe Lys Lys Thr Lys           
315                 320                 325                 330           

gag ata aga ttt tca att gag aaa gga att gct ggc caa gta gca aga       1121
Glu Ile Arg Phe Ser Ile Glu Lys Gly Ile Ala Gly Gln Val Ala Arg           
                335                 340                 345               

aca ggg gaa gtc ctg aac att cca gat gcc tat gca gac cca cgc ttt       1169
Thr Gly Glu Val Leu Asn Ile Pro Asp Ala Tyr Ala Asp Pro Arg Phe           
            350                 355                 360                   

aac aga gaa gta gac ttg tac aca ggc tac acc acg cgg aac atc ctg       1217
Asn Arg Glu Val Asp Leu Tyr Thr Gly Tyr Thr Thr Arg Asn Ile Leu           
        365                 370                 375                       

tgc atg ccc atc gtc agc cga ggc agc gtg ata ggt gtg gtg cag atg       1265
Cys Met Pro Ile Val Ser Arg Gly Ser Val Ile Gly Val Val Gln Met           
    380                 385                 390                           

gtc aac aaa atc agt ggc agt gcc ttc tct aaa aca gat gaa aac aac       1313
Val Asn Lys Ile Ser Gly Ser Ala Phe Ser Lys Thr Asp Glu Asn Asn           
395                 400                 405                 410           

ttc aaa atg ttt gcc gtc ttt tgt gct tta gcc tta cac tgt gct aat       1361
Phe Lys Met Phe Ala Val Phe Cys Ala Leu Ala Leu His Cys Ala Asn           
                415                 420                 425               

atg tat cat aga att cgc cac tca gag tgc att tac cgg gta acg atg       1409
Met Tyr His Arg Ile Arg His Ser Glu Cys Ile Tyr Arg Val Thr Met           
            430                 435                 440                   

gaa aag ctg tcc tac cat agc att tgt act tca gaa gag tgg caa ggt       1457
Glu Lys Leu Ser Tyr His Ser Ile Cys Thr Ser Glu Glu Trp Gln Gly           
        445                 450                 455                       

ctc atg caa ttc acc ctt ccc gtg cgt ctc tgc aaa gaa att gaa tta       1505
Leu Met Gln Phe Thr Leu Pro Val Arg Leu Cys Lys Glu Ile Glu Leu           
    460                 465                 470                           

ttc cac ttt gac att ggt cct ttt gaa aac atg tgg cct gga att ttt       1553
Phe His Phe Asp Ile Gly Pro Phe Glu Asn Met Trp Pro Gly Ile Phe           
475                 480                 485                 490           

gtc tac atg gtt cat cgg tcc tgt ggg aca tcc tgc ttt gag ctt gaa       1601
Val Tyr Met Val His Arg Ser Cys Gly Thr Ser Cys Phe Glu Leu Glu           
                495                 500                 505               

aag ttg tgt cgt ttt att atg tct gtg aag aag aac tat cgg cgg gtt       1649
Lys Leu Cys Arg Phe Ile Met Ser Val Lys Lys Asn Tyr Arg Arg Val           
            510                 515                 520                   

cct tat cac aac tgg aag cat gcg gtc act gta gca cac tgc atg tat       1697
Pro Tyr His Asn Trp Lys His Ala Val Thr Val Ala His Cys Met Tyr           
        525                 530                 535                       

gcc ata ctt cag aac aat cac acg ctt ttc aca gac ctt gag cgc aaa       1745
Ala Ile Leu Gln Asn Asn His Thr Leu Phe Thr Asp Leu Glu Arg Lys           
    540                 545                 550                           

gga ctg ctg att gcg tgt ctg tgt cat gac ctg gac cac agg ggc ttc       1793
Gly Leu Leu Ile Ala Cys Leu Cys His Asp Leu Asp His Arg Gly Phe           
555                 560                 565                 570           

agt aac agc tac ctg cag aag ttc gac cac cct ctg gcc gct ctc tac       1841
Ser Asn Ser Tyr Leu Gln Lys Phe Asp His Pro Leu Ala Ala Leu Tyr           
                575                 580                 585               

tcc act tcc acc atg gag cag cac cac ttc tcc cag act gtg tcc atc       1889
Ser Thr Ser Thr Met Glu Gln His His Phe Ser Gln Thr Val Ser Ile           
            590                 595                 600                   

ctc cag ttg gaa ggg cac aat atc ttc tcc act ctg agc tcc agt gaa       1937
Leu Gln Leu Glu Gly His Asn Ile Phe Ser Thr Leu Ser Ser Ser Glu           
        605                 610                 615                       

tat gag cag gtg ctt gag atc atc cgc aaa gcc atc att gcc aca gac       1985
Tyr Glu Gln Val Leu Glu Ile Ile Arg Lys Ala Ile Ile Ala Thr Asp           
    620                 625                 630                           

ctt gct tta tac ttt gga aac agg aag cag ttg gaa gag atg tac cag       2033
Leu Ala Leu Tyr Phe Gly Asn Arg Lys Gln Leu Glu Glu Met Tyr Gln           
635                 640                 645                 650           

acc gga tca cta aac ctt aat aat caa tca cat aga gac cgt gta att       2081
Thr Gly Ser Leu Asn Leu Asn Asn Gln Ser His Arg Asp Arg Val Ile           
                655                 660                 665               

ggt ttg atg atg act gcc tgt gac ctt tgt tct gtg aca aaa ctg tgg       2129
Gly Leu Met Met Thr Ala Cys Asp Leu Cys Ser Val Thr Lys Leu Trp           
            670                 675                 680                   

ccc gtt aca aaa ttg acg gca aat gat ata tat gca gaa ttc tgg gct       2177
Pro Val Thr Lys Leu Thr Ala Asn Asp Ile Tyr Ala Glu Phe Trp Ala           
        685                 690                 695                       

gag ggt gat gaa atg aag aaa ttg gga ata cag cct att cct atg atg       2225
Glu Gly Asp Glu Met Lys Lys Leu Gly Ile Gln Pro Ile Pro Met Met           
    700                 705                 710                           

gac aga gac aag aag gat gaa gtc ccc caa ggc cag ctt ggg ttc tac       2273
Asp Arg Asp Lys Lys Asp Glu Val Pro Gln Gly Gln Leu Gly Phe Tyr           
715                 720                 725                 730           

aat gcc gtg gcc att ccc tgc tat aca acc ctt acc cag atc ctc cct       2321
Asn Ala Val Ala Ile Pro Cys Tyr Thr Thr Leu Thr Gln Ile Leu Pro           
                735                 740                 745               

ccc acg gag cct ctt ctg aaa gca tgc agg gat aat ctc agt cag tgg       2369
Pro Thr Glu Pro Leu Leu Lys Ala Cys Arg Asp Asn Leu Ser Gln Trp           
            750                 755                 760                   

gag aag gtg att cga ggg gag gag act gca acc tgg att tca tcc cca       2417
Glu Lys Val Ile Arg Gly Glu Glu Thr Ala Thr Trp Ile Ser Ser Pro           
        765                 770                 775                       

tcc gtg gct cag aag gca gct gca tct gaa gat tga gcactggtca            2463
Ser Val Ala Gln Lys Ala Ala Ala Ser Glu Asp                               
    780                 785                                               

ccctgacacg ctgtcccacc tacagatcct catcttgctt ctttgacatt cttttccttt     2523

ttttgggggg ggtgggggga acctgcacct ggtaactggg gtgcaaacct cttcaagaag     2583

gtaacatcaa ataaataagt caagcagagg acttcctgcc aatctcttct gtgaggcatc     2643

atagacactg agcaaccagg accaccccca cgttcagaaa tcagctggcc aagtgactcc     2703

atttgacttg caaaccagcc ttttctaata ggctaatatt gctgaggcct taaaggaaat     2763

ggacaaaaat tatccagaag gggtactttt ccattgtatc tttctaataa gggtttaaaa     2823

tggtactatt atggtattgt acttgggctt taacatcaat gttgctttga tgttgttgga     2883

tataaatagg aatttttaca cattactatt gtgaatggtg aatgttcatg tatgacctac     2943

ttgtaattaa cttgagttgt agtccacagc ctcaggacaa atgtcgttga ggttacagag     3003

taagaaatga tggcaaaacg tcaaactctt atttcagagc ttcatgaatt tagttagact     3063

aaacataatt ctttaagttc aacctaaagg gctgagatca ataaatttaa cactagacga     3123

agtagacttc ctgtcttttt gagaagagat gaggtatatg ttacaataaa tctcagaact     3183

tcaagtagca gttcaaaaga tgtcagtttt taaaattgtt tttgttgttg tcttggcagt     3243

tttactgaac cctttgcata aagaacaaaa taaaagctcg gcattgtaat ttttttaatg     3303

gacaagtctt atggatacga agggtacatt tttcataatg attcctttat attttcactt     3363

tgtgtcattg cagaatttta gactctcatt cacaatgaaa agtttatttt aaacattgtt     3423

taattaaaat accatacagt tctcttttaa acatcaaacc ataaaaagtg tattttgtaa     3483

ttttactctg acctgccgca gtcacctctc acttatctct tccacgtact gcacggtcgt     3543

atttcatgag ctttctgtcc atagcacaga aacagagcag aaagtagtac aatcatgttg     3603

gaccttcttt ctgttctctt tactcttctc acagatcaga tcactccata gaagcctgtg     3663

ggtttcgatg gtttcttcta tacacctttt tggttgacca gtattactat acaatgtaag     3723

tgttttaaaa aatacgaaag taatactctg caccccttcc tacaaagatg ataaagcagt     3783

cacttctggc gcattttaat aatttaaaga tttttagtgc aatggcacgg taacctccaa     3843

acctgaatta gacagagact cactcaggaa gtgacaggcc catcatatca aataacttat     3903

tcacttttca tgtggcagga aactggaata tcgcttttaa taaaatggaa aaatatgctt     3963

ctacatattt accaccatag gcgttttgtt catatgagcc tggtttgtgc aaaattaaat     4023

cagaggcttc tacaacatgg tttatttatg ttgtagcaaa gttggctcta cataaacatt     4083

gttcttattt taaaattaac actatgtgtt cagttttctt gtgggcttct gaaagttgcc     4143

atcttccctc cgtggagctc catttgctat tttcattata cactatgagg taaaatgtaa     4203

taacaaaaga gagagaagta ccactgtggc tagatatata cacacacata tatatatgga     4263

tggatgtaat atatgtagaa cacacacata gatgtatata ggatacacac tcatgtatgt     4323

aaacgtatac atatgtgtat atatgataca tacacataca cacacacgag agacagaagg     4383

aaagagagga agagagaagc aaacatgtag gaaaaaatat aaatcagccc cattctccca     4443

ttctttaaga acaatgattt ttcttgatgg aaaatgcata tcacttgaca gttgacaaga     4503

aagtgtcatt tttgtgttag tgtatcatat aattgaattt gaacaagata catatttttc     4563

tgcatacaaa tttatgaagc tggagtctac caaacacagc tttagtcaca aaagttagtt     4623

tagttatctc atttcgcttg gagatggaat ttcaggaagg gatatattat ttaagattat     4683

tgtttaatta caagaatttt aaaagaatgt atgaattctg ttttttaata tagaaaataa     4743

ttatggagtt aggaatctca tggctacatt tacattttta ggttattaca gaaaattctc     4803

ttaatttatt atagtcaagt gtattatgta atctctattt agaacagttt cccaaaggaa     4863

tgtgattgga tttactggtt ggttaatttc ttgtgaaata ttgtcataat agaagcacag     4923

cttgaacaaa agactgaatt ctgatataaa ctgtcaatat tgcttttacc atgtgtaaga     4983

tttacttagt aatcacagat ttacctaaaa taaaaggacc cgggttgcag tgatatttag     5043

ttaatgattt gttttggaaa acatgcagtt aggagtattt ttgtattttg tcagatgttt     5103

aggagacaga ctttcgggtc atgtttcttg tcttgttccc agatcttttc ttaaaagaac     5163

agtgtgacac cagaagccaa gagatggttt ttactaacaa cagctttgat gagttcctat     5223

taaggtcgta ttgtgtattg tgccaaattt tccacccagt ataaatttag taacccgcta     5283

tgagcatatg taggatattc aatttgcaga tacttttgtt ggttatgttg gtttataata     5343

gacaagtttt atggtcatat gcaattattc cattatcttt ttggacacag tgaatatgtt     5403

ttttagctaa aaatgtcctt ggaaacataa atgcctgcca ataacatgga atattgaatt     5463

cgggcaatgt gaattgatta attagaaaag ggtcaaaaga aatacaatgg atgtggaaac     5523

taattctaaa aaatagccct attaataggg cagagactct ggtccatttc ccagctgtac     5583

ttctctctaa gaggtgtatg aaaaacccat cttgcaaaag agaccaaaat attagacaca     5643

atcgttccca ttcctgactc ttcaatggaa aaggaaggta cagatgttta cagtggtgcc     5703

ccaggtgact cgttctcacc acaacaaaag caactaattg gaaactagat gtgttcaata     5763

atagatttcc tcttttttgg catgcttttt agattttttt tcattttgta aaatctcagt     5823

taatttttct ttattggtat atttgtgtat gcgagacaaa tcctgtattg tacaggatat     5883

aaatagatgc ataaatcctt agatacctgg gttttttaat aggtttaggt ttgggtattg     5943

tgtttctggt cttttaactc aaaattaagg tttgagcttt aataggacta aattattcac     6003

ctgccttggc ctgtgccttt attttaaata ctgcaatttt acttcttcat tcatgtattt     6063

attattttgc ttttcttgct taagtataat tgaaaatatt tgcaggaacg cacaattcat     6123

tttatcaagt tgaatgaata ggaccattct ctcctcatca gatttctgtt ctttatttga     6183

cttcattgac atataccctg gtgactataa ccagtgaact gttcagagtc agtcttttcg     6243

gcaagaactt cagagaactg tgacactggt tatgatgtga ttttgggggg tttcaggtac     6303

ctaagcatga tttttaaaat cacttctctc tttacatatt tcgaacatat gtttgctttc     6363

tacactttgc agattttatt taggatttaa ttctttaaag actatattca tttagtcact     6423

atagtggatc tcttctactg caagtattca tctgattttt aaattatgta aaatgtaaat     6483

cagccaagta tgtcatccgt tatagtttcc ccatgctttc agcgcatggc catgagattt     6543

ttacatgtgc ataagtattt agccaataca cattttgctg acttctttaa ccatttatat     6603

tgtttaaatt agtaatatcc aatgcagtgc acactttttt gtcttttttc caacggaata     6663

ttttggttgt ctgtagcgtt ggaagcattt tatatgataa aaatagcaag aaaaaattaa     6723

aaagtgtcaa cggtgtgctg gttctaaatt aagaagatag aacaaagaga aagacattaa     6783

tgttacctaa gaaacacatt taacatccga agaagcaatg ctgtcctcac ttgatgtttc     6843

tcttctcaac ccagcaatgg agagcagggc ttgcaaagcc gtacagagcc tacgtgctct     6903

ttcctgcaag tgggagaaaa ctaatcaatg gcacacaggg ccaggtgtgg ccctgtgagg     6963

caaaggataa tgtcacctca ggaccaaggt ggaaacttac agctgaatcc agggcttact     7023

aagtagggaa gtcagtttac atatttcagt tttcctctga tgtttttgag gtactgtgta     7083

tttgcagaag tttaagcaga agggttttgt ttctattgta agttaggttc taaaagtgta     7143

taatctgata ctctagccca actgaaatat tatatcttgg gcgttacagc ctttgtcttt     7203

ttctttagtc accttaatac ccagtcctat gctgtatctc tgatagccta tataaatgac     7263

atataggaat attattttcc atatgatctg ttgtatggtg tatatgctat gtgttcattt     7323

cgtgtgcaag ttcagagtgt aatagattta cccagagaag gtgtttctat acaatgcccc     7383

tacctatttg aaattacatg cttgcccaac acactgtgaa atagttacca aaatttgtac     7443

aaatgcagca tcttcattct ttctgagaag acaagatggt tttctttaca tgaacaaatg     7503

aacaaaagag atcctagatc cataacgtag ctaaggcatc taagagtttg ctgttgataa     7563

tcttgctgac caaaaactac tggagagtaa cacaggttat atgccatcac aaatacaatg     7623

ctcatgaaga actgatttgt agagtcaatg aacctgtgtc cagaatttta ataggctctc     7683

tattggaagg agaaagaatt tcaagttaac agtatctaac tttatcatag ttgatgttag     7743

taaattttaa aaaatgattt tatatgtatg acaaaaatct ttgtaaaatg cgcaagtgca     7803

ataatttaaa gaggtcttaa ctttgcattt ataaattata aatattgtac atgtgtgtaa     7863

ttttttcatg tattcatttg cagtctttgt atttaaaaaa catttactgt tatgtttgta     7923

taatagaaca gtaatcattt attataatct aggcaagttg taaataaatt cataattcaa     7983

acagccagta tatatgcata tatgagtgtt atattgcaaa atctttgttt tacttacatg     8043

gttaaagcag caagaattct tttgttgata tgtaattata cacataaaat atatatatgt     8103

atgatacatg aaatatattt agaaatgttc ataattttaa tggatatcct ttggtgtgaa     8163

taattgaata cagagttttt aaaata                                          8189


<210>  400
<211>  789
<212>  PRT
<213>  Homo sapiens

<400>  400

Met Glu Asp Gly Pro Ser Asn Asn Ala Ser Cys Phe Arg Arg Leu Thr 
1               5                   10                  15      


Glu Cys Phe Leu Ser Pro Ser Leu Thr Asp Glu Lys Val Lys Ala Tyr 
            20                  25                  30          


Leu Ser Leu His Pro Gln Val Leu Asp Glu Phe Val Ser Glu Ser Val 
        35                  40                  45              


Ser Ala Glu Thr Val Glu Lys Trp Leu Lys Arg Lys Asn Asn Lys Ser 
    50                  55                  60                  


Glu Asp Glu Ser Ala Pro Lys Glu Val Ser Arg Tyr Gln Asp Thr Asn 
65                  70                  75                  80  


Met Gln Gly Val Val Tyr Glu Leu Asn Ser Tyr Ile Glu Gln Arg Leu 
                85                  90                  95      


Asp Thr Gly Gly Asp Asn Gln Leu Leu Leu Tyr Glu Leu Ser Ser Ile 
            100                 105                 110         


Ile Lys Ile Ala Thr Lys Ala Asp Gly Phe Ala Leu Tyr Phe Leu Gly 
        115                 120                 125             


Glu Cys Asn Asn Ser Leu Cys Ile Phe Thr Pro Pro Gly Ile Lys Glu 
    130                 135                 140                 


Gly Lys Pro Arg Leu Ile Pro Ala Gly Pro Ile Thr Gln Gly Thr Thr 
145                 150                 155                 160 


Val Ser Ala Tyr Val Ala Lys Ser Arg Lys Thr Leu Leu Val Glu Asp 
                165                 170                 175     


Ile Leu Gly Asp Glu Arg Phe Pro Arg Gly Thr Gly Leu Glu Ser Gly 
            180                 185                 190         


Thr Arg Ile Gln Ser Val Leu Cys Leu Pro Ile Val Thr Ala Ile Gly 
        195                 200                 205             


Asp Leu Ile Gly Ile Leu Glu Leu Tyr Arg His Trp Gly Lys Glu Ala 
    210                 215                 220                 


Phe Cys Leu Ser His Gln Glu Val Ala Thr Ala Asn Leu Ala Trp Ala 
225                 230                 235                 240 


Ser Val Ala Ile His Gln Val Gln Val Cys Arg Gly Leu Ala Lys Gln 
                245                 250                 255     


Thr Glu Leu Asn Asp Phe Leu Leu Asp Val Ser Lys Thr Tyr Phe Asp 
            260                 265                 270         


Asn Ile Val Ala Ile Asp Ser Leu Leu Glu His Ile Met Ile Tyr Ala 
        275                 280                 285             


Lys Asn Leu Val Asn Ala Asp Arg Cys Ala Leu Phe Gln Val Asp His 
    290                 295                 300                 


Lys Asn Lys Glu Leu Tyr Ser Asp Leu Phe Asp Ile Gly Glu Glu Lys 
305                 310                 315                 320 


Glu Gly Lys Pro Val Phe Lys Lys Thr Lys Glu Ile Arg Phe Ser Ile 
                325                 330                 335     


Glu Lys Gly Ile Ala Gly Gln Val Ala Arg Thr Gly Glu Val Leu Asn 
            340                 345                 350         


Ile Pro Asp Ala Tyr Ala Asp Pro Arg Phe Asn Arg Glu Val Asp Leu 
        355                 360                 365             


Tyr Thr Gly Tyr Thr Thr Arg Asn Ile Leu Cys Met Pro Ile Val Ser 
    370                 375                 380                 


Arg Gly Ser Val Ile Gly Val Val Gln Met Val Asn Lys Ile Ser Gly 
385                 390                 395                 400 


Ser Ala Phe Ser Lys Thr Asp Glu Asn Asn Phe Lys Met Phe Ala Val 
                405                 410                 415     


Phe Cys Ala Leu Ala Leu His Cys Ala Asn Met Tyr His Arg Ile Arg 
            420                 425                 430         


His Ser Glu Cys Ile Tyr Arg Val Thr Met Glu Lys Leu Ser Tyr His 
        435                 440                 445             


Ser Ile Cys Thr Ser Glu Glu Trp Gln Gly Leu Met Gln Phe Thr Leu 
    450                 455                 460                 


Pro Val Arg Leu Cys Lys Glu Ile Glu Leu Phe His Phe Asp Ile Gly 
465                 470                 475                 480 


Pro Phe Glu Asn Met Trp Pro Gly Ile Phe Val Tyr Met Val His Arg 
                485                 490                 495     


Ser Cys Gly Thr Ser Cys Phe Glu Leu Glu Lys Leu Cys Arg Phe Ile 
            500                 505                 510         


Met Ser Val Lys Lys Asn Tyr Arg Arg Val Pro Tyr His Asn Trp Lys 
        515                 520                 525             


His Ala Val Thr Val Ala His Cys Met Tyr Ala Ile Leu Gln Asn Asn 
    530                 535                 540                 


His Thr Leu Phe Thr Asp Leu Glu Arg Lys Gly Leu Leu Ile Ala Cys 
545                 550                 555                 560 


Leu Cys His Asp Leu Asp His Arg Gly Phe Ser Asn Ser Tyr Leu Gln 
                565                 570                 575     


Lys Phe Asp His Pro Leu Ala Ala Leu Tyr Ser Thr Ser Thr Met Glu 
            580                 585                 590         


Gln His His Phe Ser Gln Thr Val Ser Ile Leu Gln Leu Glu Gly His 
        595                 600                 605             


Asn Ile Phe Ser Thr Leu Ser Ser Ser Glu Tyr Glu Gln Val Leu Glu 
    610                 615                 620                 


Ile Ile Arg Lys Ala Ile Ile Ala Thr Asp Leu Ala Leu Tyr Phe Gly 
625                 630                 635                 640 


Asn Arg Lys Gln Leu Glu Glu Met Tyr Gln Thr Gly Ser Leu Asn Leu 
                645                 650                 655     


Asn Asn Gln Ser His Arg Asp Arg Val Ile Gly Leu Met Met Thr Ala 
            660                 665                 670         


Cys Asp Leu Cys Ser Val Thr Lys Leu Trp Pro Val Thr Lys Leu Thr 
        675                 680                 685             


Ala Asn Asp Ile Tyr Ala Glu Phe Trp Ala Glu Gly Asp Glu Met Lys 
    690                 695                 700                 


Lys Leu Gly Ile Gln Pro Ile Pro Met Met Asp Arg Asp Lys Lys Asp 
705                 710                 715                 720 


Glu Val Pro Gln Gly Gln Leu Gly Phe Tyr Asn Ala Val Ala Ile Pro 
                725                 730                 735     


Cys Tyr Thr Thr Leu Thr Gln Ile Leu Pro Pro Thr Glu Pro Leu Leu 
            740                 745                 750         


Lys Ala Cys Arg Asp Asn Leu Ser Gln Trp Glu Lys Val Ile Arg Gly 
        755                 760                 765             


Glu Glu Thr Ala Thr Trp Ile Ser Ser Pro Ser Val Ala Gln Lys Ala 
    770                 775                 780                 


Ala Ala Ser Glu Asp 
785                 


<210>  401
<211>  6860
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (124)..(6309)

<400>  401
gccctgggag aaatcctccc ttcactggga gagaacttct ctcccagggc ggtgcgaccc       60

ggagctccag cgcccgagtc tccacttcgt ttgctgaaac ttgctttcta ccagctaaga      120

acc atg ctg cga gtg att gtg gaa tct gcc agc aat atc cct aaa acg        168
    Met Leu Arg Val Ile Val Glu Ser Ala Ser Asn Ile Pro Lys Thr           
    1               5                   10                  15            

aaa ttt ggc aag ccg gat cct att gtt tct gtc att ttt aag gat gag        216
Lys Phe Gly Lys Pro Asp Pro Ile Val Ser Val Ile Phe Lys Asp Glu           
                20                  25                  30                

aaa aag aaa aca aag aaa gtt gat aat gaa ttg aac cct gtc tgg aat        264
Lys Lys Lys Thr Lys Lys Val Asp Asn Glu Leu Asn Pro Val Trp Asn           
            35                  40                  45                    

gag att ttg gag ttt gac ttg agg ggt ata cca ctg gac ttt tca tct        312
Glu Ile Leu Glu Phe Asp Leu Arg Gly Ile Pro Leu Asp Phe Ser Ser           
        50                  55                  60                        

tcc ctt ggg att att gtg aaa gat ttt gag aca att gga caa aat aaa        360
Ser Leu Gly Ile Ile Val Lys Asp Phe Glu Thr Ile Gly Gln Asn Lys           
    65                  70                  75                            

tta att ggc acg gcg act gta gcc ctg aag gac ctg act ggt gac cag        408
Leu Ile Gly Thr Ala Thr Val Ala Leu Lys Asp Leu Thr Gly Asp Gln           
80                  85                  90                  95            

agc aga tcc ctg ccg tac aag ctg atc tcc ctg cta aat gaa aaa ggg        456
Ser Arg Ser Leu Pro Tyr Lys Leu Ile Ser Leu Leu Asn Glu Lys Gly           
                100                 105                 110               

caa gat act ggg gcc acc att gac ttg gtg atc ggc tat gat ccg cct        504
Gln Asp Thr Gly Ala Thr Ile Asp Leu Val Ile Gly Tyr Asp Pro Pro           
            115                 120                 125                   

tct gct cca cat cca aat gac ctg agc ggg ccc agc gtg cca ggc atg        552
Ser Ala Pro His Pro Asn Asp Leu Ser Gly Pro Ser Val Pro Gly Met           
        130                 135                 140                       

gga gga gat ggg gaa gaa gat gaa ggt gat gaa gac agg ttg gac aat        600
Gly Gly Asp Gly Glu Glu Asp Glu Gly Asp Glu Asp Arg Leu Asp Asn           
    145                 150                 155                           

gca gtc agg ggc cct ggg ccc aag ggg cca gtt ggg acg gtg tcg gaa        648
Ala Val Arg Gly Pro Gly Pro Lys Gly Pro Val Gly Thr Val Ser Glu           
160                 165                 170                 175           

gct cag ctt gct cgg agg ctc acc aaa gta aag aac agc cgg cgg atg        696
Ala Gln Leu Ala Arg Arg Leu Thr Lys Val Lys Asn Ser Arg Arg Met           
                180                 185                 190               

ctg tca aat aag cca cag gac ttc cag atc cgc gtc cga gtg att gag        744
Leu Ser Asn Lys Pro Gln Asp Phe Gln Ile Arg Val Arg Val Ile Glu           
            195                 200                 205                   

ggc cga cag tta agt ggt aac aac ata agg cct gtg gtc aaa gtt cac        792
Gly Arg Gln Leu Ser Gly Asn Asn Ile Arg Pro Val Val Lys Val His           
        210                 215                 220                       

gtc tgt ggc cag aca cac cga aca aga atc aag aga gga aac aac cct        840
Val Cys Gly Gln Thr His Arg Thr Arg Ile Lys Arg Gly Asn Asn Pro           
    225                 230                 235                           

ttt ttt gat gag ttg ttt ttc tac aat gtc aac atg acc cct tct gaa        888
Phe Phe Asp Glu Leu Phe Phe Tyr Asn Val Asn Met Thr Pro Ser Glu           
240                 245                 250                 255           

ttg atg gat gag atc atc agc atc cgg gtt tat aat tct cac tct ctg        936
Leu Met Asp Glu Ile Ile Ser Ile Arg Val Tyr Asn Ser His Ser Leu           
                260                 265                 270               

cgg gca gat tgt ctg atg ggg gaa ttt aag att gat gtt gga ttt gtt        984
Arg Ala Asp Cys Leu Met Gly Glu Phe Lys Ile Asp Val Gly Phe Val           
            275                 280                 285                   

tat gat gaa cct ggc cat gct gtc atg aga aag tgg ctt ctt ctc aat       1032
Tyr Asp Glu Pro Gly His Ala Val Met Arg Lys Trp Leu Leu Leu Asn           
        290                 295                 300                       

gac ccg gaa gat acc agt tca ggt tct aaa ggt tat atg aaa gtc agc       1080
Asp Pro Glu Asp Thr Ser Ser Gly Ser Lys Gly Tyr Met Lys Val Ser           
    305                 310                 315                           

atg ttt gtc ctg gga acc gga gat gag cct cct cct gag aga cga gat       1128
Met Phe Val Leu Gly Thr Gly Asp Glu Pro Pro Pro Glu Arg Arg Asp           
320                 325                 330                 335           

cgt gat aat gac agt gat gat gtg gag agt aat ttg tta ctc cct gct       1176
Arg Asp Asn Asp Ser Asp Asp Val Glu Ser Asn Leu Leu Leu Pro Ala           
                340                 345                 350               

ggc att gcc ctc cgg tgg gtg acc ttc ttg ctg aaa atc tac cga gct       1224
Gly Ile Ala Leu Arg Trp Val Thr Phe Leu Leu Lys Ile Tyr Arg Ala           
            355                 360                 365                   

gag gac atc ccc cag atg gat gat gcc ttc tca cag aca gta aag gaa       1272
Glu Asp Ile Pro Gln Met Asp Asp Ala Phe Ser Gln Thr Val Lys Glu           
        370                 375                 380                       

ata ttt gga ggc aat gca gat aag aaa aat ctc gtg gat cct ttt gta       1320
Ile Phe Gly Gly Asn Ala Asp Lys Lys Asn Leu Val Asp Pro Phe Val           
    385                 390                 395                           

gaa gtt tcc ttt gct gga aaa aag gtt tgt aca aac ata att gag aaa       1368
Glu Val Ser Phe Ala Gly Lys Lys Val Cys Thr Asn Ile Ile Glu Lys           
400                 405                 410                 415           

aat gca aac cca gag tgg aat cag gtc gtc aat ctt cag atc aag ttt       1416
Asn Ala Asn Pro Glu Trp Asn Gln Val Val Asn Leu Gln Ile Lys Phe           
                420                 425                 430               

cct tca gtg tgt gaa aaa ata aaa cta aca ata tat gac tgg gac cgt       1464
Pro Ser Val Cys Glu Lys Ile Lys Leu Thr Ile Tyr Asp Trp Asp Arg           
            435                 440                 445                   

ctt act aaa aat gat gta gtt gga aca aca tat cta cac ctc tct aaa       1512
Leu Thr Lys Asn Asp Val Val Gly Thr Thr Tyr Leu His Leu Ser Lys           
        450                 455                 460                       

att gct gcc tct ggt ggg gaa gtg gaa gat ttc tca tct tcg gga act       1560
Ile Ala Ala Ser Gly Gly Glu Val Glu Asp Phe Ser Ser Ser Gly Thr           
    465                 470                 475                           

ggg gct gca tca tat aca gta aac aca gga gaa aca gag gta ggc ttt       1608
Gly Ala Ala Ser Tyr Thr Val Asn Thr Gly Glu Thr Glu Val Gly Phe           
480                 485                 490                 495           

gtt cca acg ttt gga cct tgt tac ctg aat ctt tat gga agc ccc aga       1656
Val Pro Thr Phe Gly Pro Cys Tyr Leu Asn Leu Tyr Gly Ser Pro Arg           
                500                 505                 510               

gag tac acg gga ttc cca gac ccc tat gat gag ctg aat act gga aag       1704
Glu Tyr Thr Gly Phe Pro Asp Pro Tyr Asp Glu Leu Asn Thr Gly Lys           
            515                 520                 525                   

ggg gaa gga gtt gcc tac aga ggc agg atc ttg gtt gaa tta gcc act       1752
Gly Glu Gly Val Ala Tyr Arg Gly Arg Ile Leu Val Glu Leu Ala Thr           
        530                 535                 540                       

ttt ctt gag aag aca cca cca gat aaa aag ctt gag ccc att tca aat       1800
Phe Leu Glu Lys Thr Pro Pro Asp Lys Lys Leu Glu Pro Ile Ser Asn           
    545                 550                 555                           

gat gac ctg ctg gtt gtt gag aaa tac cag cga agg cgg aag tac agc       1848
Asp Asp Leu Leu Val Val Glu Lys Tyr Gln Arg Arg Arg Lys Tyr Ser           
560                 565                 570                 575           

ctg tct gcc gtg ttt cat tca gcc acc atg ttg caa gat gtt ggt gag       1896
Leu Ser Ala Val Phe His Ser Ala Thr Met Leu Gln Asp Val Gly Glu           
                580                 585                 590               

gcc att cag ttt gaa gtc agc att ggg aac tat ggc aac aag ttt gac       1944
Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe Asp           
            595                 600                 605                   

acc acc tgt aag cct ttg gca tca aca act cag tac agc cgt gct gta       1992
Thr Thr Cys Lys Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala Val           
        610                 615                 620                       

ttt gat ggc aac tac tat tat tac ttg cct tgg gcc cac acc aag cca       2040
Phe Asp Gly Asn Tyr Tyr Tyr Tyr Leu Pro Trp Ala His Thr Lys Pro           
    625                 630                 635                           

gtt gtt acc ctg act tca tac tgg gag gat att agt cat cgc ctg gat       2088
Val Val Thr Leu Thr Ser Tyr Trp Glu Asp Ile Ser His Arg Leu Asp           
640                 645                 650                 655           

gcg gtg aac act ctc cta gct atg gca gaa cgg ctg caa aca aat ata       2136
Ala Val Asn Thr Leu Leu Ala Met Ala Glu Arg Leu Gln Thr Asn Ile           
                660                 665                 670               

gaa gct cta aaa tca ggg ata caa ggt aaa att cct gca aac cag ctg       2184
Glu Ala Leu Lys Ser Gly Ile Gln Gly Lys Ile Pro Ala Asn Gln Leu           
            675                 680                 685                   

gct gaa ttg tgg ctg aag ctg ata gat gaa gtt ata gaa gac acg aga       2232
Ala Glu Leu Trp Leu Lys Leu Ile Asp Glu Val Ile Glu Asp Thr Arg           
        690                 695                 700                       

tac acg ttg cct ctc aca gaa gga aaa gcc aac gtc aca gtt ctc gat       2280
Tyr Thr Leu Pro Leu Thr Glu Gly Lys Ala Asn Val Thr Val Leu Asp           
    705                 710                 715                           

act cag atc cga aag ctg cgg tcc agg tct ctc tcc caa ata cat gag       2328
Thr Gln Ile Arg Lys Leu Arg Ser Arg Ser Leu Ser Gln Ile His Glu           
720                 725                 730                 735           

gcg gct gtg agg atg agg tcg gaa gcc aca gat gtg aag tcc aca ctg       2376
Ala Ala Val Arg Met Arg Ser Glu Ala Thr Asp Val Lys Ser Thr Leu           
                740                 745                 750               

gca gaa att gag gac tgg ctt gat aaa tta atg cag ctg act gaa gag       2424
Ala Glu Ile Glu Asp Trp Leu Asp Lys Leu Met Gln Leu Thr Glu Glu           
            755                 760                 765                   

cca cag aac agc atg cct gac atc atc atc tgg atg atc cgg gga gag       2472
Pro Gln Asn Ser Met Pro Asp Ile Ile Ile Trp Met Ile Arg Gly Glu           
        770                 775                 780                       

aag aga ctg gcc tat gca cga att ccc gca cat cag gtc ttg tac tcc       2520
Lys Arg Leu Ala Tyr Ala Arg Ile Pro Ala His Gln Val Leu Tyr Ser           
    785                 790                 795                           

acc agt ggt gag aat gca tct gga aaa tac tgt ggg aaa acc caa acc       2568
Thr Ser Gly Glu Asn Ala Ser Gly Lys Tyr Cys Gly Lys Thr Gln Thr           
800                 805                 810                 815           

atc ttt ctg aag tat cca cag gag aaa aac aac ggg cca aag gtg cct       2616
Ile Phe Leu Lys Tyr Pro Gln Glu Lys Asn Asn Gly Pro Lys Val Pro           
                820                 825                 830               

gtg gag ttg cga gtg aac atc tgg cta ggc tta agt gct gtg gag aag       2664
Val Glu Leu Arg Val Asn Ile Trp Leu Gly Leu Ser Ala Val Glu Lys           
            835                 840                 845                   

aag ttt aac agc ttc gca gaa gga act ttc acc gtc ttt gct gaa atg       2712
Lys Phe Asn Ser Phe Ala Glu Gly Thr Phe Thr Val Phe Ala Glu Met           
        850                 855                 860                       

tat gaa aat caa gct ctc atg ttt gga aaa tgg ggt act tct gga tta       2760
Tyr Glu Asn Gln Ala Leu Met Phe Gly Lys Trp Gly Thr Ser Gly Leu           
    865                 870                 875                           

gta gga cgt cat aag ttt tct gat gtc aca gga aaa ata aaa ctc aag       2808
Val Gly Arg His Lys Phe Ser Asp Val Thr Gly Lys Ile Lys Leu Lys           
880                 885                 890                 895           

agg gaa ttt ttt ctg cct cca aaa ggc tgg gaa tgg gaa gga gag tgg       2856
Arg Glu Phe Phe Leu Pro Pro Lys Gly Trp Glu Trp Glu Gly Glu Trp           
                900                 905                 910               

ata gtt gat cct gaa aga agc ttg ctg act gag gca gat gca ggt cac       2904
Ile Val Asp Pro Glu Arg Ser Leu Leu Thr Glu Ala Asp Ala Gly His           
            915                 920                 925                   

acg gag ttc act gat gaa gtc tat cag aac gag agc cgc tac ccc ggg       2952
Thr Glu Phe Thr Asp Glu Val Tyr Gln Asn Glu Ser Arg Tyr Pro Gly           
        930                 935                 940                       

ggc gac tgg aag ccg gcc gag gac acc tac acg gat gcg aac ggc gat       3000
Gly Asp Trp Lys Pro Ala Glu Asp Thr Tyr Thr Asp Ala Asn Gly Asp           
    945                 950                 955                           

aaa gca gca tca ccc agc gag ttg act tgt cct cca ggt tgg gaa tgg       3048
Lys Ala Ala Ser Pro Ser Glu Leu Thr Cys Pro Pro Gly Trp Glu Trp           
960                 965                 970                 975           

gaa gat gat gca tgg tct tat gac ata aat cga gcg gtg gat gag aaa       3096
Glu Asp Asp Ala Trp Ser Tyr Asp Ile Asn Arg Ala Val Asp Glu Lys           
                980                 985                 990               

ggc tgg gaa tat gga atc acc att cct  cct gat cat aag ccc  aaa tcc     3144
Gly Trp Glu Tyr Gly Ile Thr Ile Pro  Pro Asp His Lys Pro  Lys Ser         
            995                 1000                 1005                 

tgg gtt gca  gca gag aaa atg tac  cac act cat aga cgg  cga agg        3189
Trp Val Ala  Ala Glu Lys Met Tyr  His Thr His Arg Arg  Arg Arg            
        1010                 1015                 1020                    

ctg gtc cga  aaa cgc aag aaa gat  tta aca cag act gct  tca agc        3234
Leu Val Arg  Lys Arg Lys Lys Asp  Leu Thr Gln Thr Ala  Ser Ser            
        1025                 1030                 1035                    

acc gca agg  gcc atg gag gaa ttg  caa gac caa gag ggc  tgg gaa        3279
Thr Ala Arg  Ala Met Glu Glu Leu  Gln Asp Gln Glu Gly  Trp Glu            
        1040                 1045                 1050                    

tat gct tct  cta att ggc tgg aaa  ttt cac tgg aaa caa  cgt agt        3324
Tyr Ala Ser  Leu Ile Gly Trp Lys  Phe His Trp Lys Gln  Arg Ser            
        1055                 1060                 1065                    

tca gat acc  ttc cgc cgc aga cgc  tgg agg aga aaa atg  gct cct        3369
Ser Asp Thr  Phe Arg Arg Arg Arg  Trp Arg Arg Lys Met  Ala Pro            
        1070                 1075                 1080                    

tca gaa aca  cat ggt gca gct gcc  atc ttt aaa ctt gaa  ggt gcc        3414
Ser Glu Thr  His Gly Ala Ala Ala  Ile Phe Lys Leu Glu  Gly Ala            
        1085                 1090                 1095                    

ctt ggg gca  gac act acc gaa gat  ggg gat gag aag agc  ctg gag        3459
Leu Gly Ala  Asp Thr Thr Glu Asp  Gly Asp Glu Lys Ser  Leu Glu            
        1100                 1105                 1110                    

aaa cag aag  cac agt gcc acc act  gtg ttc gga gca aac  acc ccc        3504
Lys Gln Lys  His Ser Ala Thr Thr  Val Phe Gly Ala Asn  Thr Pro            
        1115                 1120                 1125                    

att gtt tcc  tgc aat ttt gac aga  gtc tac atc tac cat  ctg cgc        3549
Ile Val Ser  Cys Asn Phe Asp Arg  Val Tyr Ile Tyr His  Leu Arg            
        1130                 1135                 1140                    

tgc tat gtc  tat caa gcc aga aac  ctc ttg gct tta gat  aag gat        3594
Cys Tyr Val  Tyr Gln Ala Arg Asn  Leu Leu Ala Leu Asp  Lys Asp            
        1145                 1150                 1155                    

agc ttt tca  gat cca tat gct cat  atc tgt ttc ctc cat  cgg agc        3639
Ser Phe Ser  Asp Pro Tyr Ala His  Ile Cys Phe Leu His  Arg Ser            
        1160                 1165                 1170                    

aaa acc act  gag atc atc cat tca  acc ctg aat ccc acg  tgg gac        3684
Lys Thr Thr  Glu Ile Ile His Ser  Thr Leu Asn Pro Thr  Trp Asp            
        1175                 1180                 1185                    

caa aca att  ata ttc gat gaa gtt  gaa atc tat ggg gaa  ccc caa        3729
Gln Thr Ile  Ile Phe Asp Glu Val  Glu Ile Tyr Gly Glu  Pro Gln            
        1190                 1195                 1200                    

aca gtt cta  cag aat cca ccc aaa  gtt atc atg gaa ctt  ttt gac        3774
Thr Val Leu  Gln Asn Pro Pro Lys  Val Ile Met Glu Leu  Phe Asp            
        1205                 1210                 1215                    

aat gac caa  gtg ggc aaa gat gaa  ttt tta gga cga agc  att ttc        3819
Asn Asp Gln  Val Gly Lys Asp Glu  Phe Leu Gly Arg Ser  Ile Phe            
        1220                 1225                 1230                    

tct cct gtg  gtg aaa ctg aac tca  gaa atg gac atc aca  ccc aaa        3864
Ser Pro Val  Val Lys Leu Asn Ser  Glu Met Asp Ile Thr  Pro Lys            
        1235                 1240                 1245                    

ctt ctc tgg  cac cca gta atg aat  gga gac aaa gcc tgc  ggg gat        3909
Leu Leu Trp  His Pro Val Met Asn  Gly Asp Lys Ala Cys  Gly Asp            
        1250                 1255                 1260                    

gtt ctt gta  act gca gag ctg att  ctg agg ggc aag gat  ggc tcc        3954
Val Leu Val  Thr Ala Glu Leu Ile  Leu Arg Gly Lys Asp  Gly Ser            
        1265                 1270                 1275                    

aac ctt ccc  att ctt ccc cct caa  agg gcg cca aat cta  tac atg        3999
Asn Leu Pro  Ile Leu Pro Pro Gln  Arg Ala Pro Asn Leu  Tyr Met            
        1280                 1285                 1290                    

gtc ccc cag  ggg atc agg cct gtg  gtc cag ctc act gcc  att gag        4044
Val Pro Gln  Gly Ile Arg Pro Val  Val Gln Leu Thr Ala  Ile Glu            
        1295                 1300                 1305                    

att cta gct  tgg ggc tta aga aat  atg aaa aac ttc cag  atg gct        4089
Ile Leu Ala  Trp Gly Leu Arg Asn  Met Lys Asn Phe Gln  Met Ala            
        1310                 1315                 1320                    

tct atc aca  tcc ccc agt ctt gtt  gtg gag tgt gga gga  gaa agg        4134
Ser Ile Thr  Ser Pro Ser Leu Val  Val Glu Cys Gly Gly  Glu Arg            
        1325                 1330                 1335                    

gtg gaa tcg  gtg gtg atc aaa aac  ctt aag aag aca ccc  aac ttt        4179
Val Glu Ser  Val Val Ile Lys Asn  Leu Lys Lys Thr Pro  Asn Phe            
        1340                 1345                 1350                    

cca agt tct  gtt ctc ttc atg aaa  gtg ttc ttg ccc aag  gag gaa        4224
Pro Ser Ser  Val Leu Phe Met Lys  Val Phe Leu Pro Lys  Glu Glu            
        1355                 1360                 1365                    

ttg tac atg  ccc cca ctg gtg atc  aag gtc atc gac cac  agg cag        4269
Leu Tyr Met  Pro Pro Leu Val Ile  Lys Val Ile Asp His  Arg Gln            
        1370                 1375                 1380                    

ttt ggg cgg  aag cct gtc gtc ggc  cag tgc acc atc gag  cgc ctg        4314
Phe Gly Arg  Lys Pro Val Val Gly  Gln Cys Thr Ile Glu  Arg Leu            
        1385                 1390                 1395                    

gac cgc ttt  cgc tgt gac cct tat  gca ggg aaa gag gac  atc gtc        4359
Asp Arg Phe  Arg Cys Asp Pro Tyr  Ala Gly Lys Glu Asp  Ile Val            
        1400                 1405                 1410                    

cca cag ctc  aaa gcc tcc ctt ctg  tct gcc cca cca tgc  cgg gac        4404
Pro Gln Leu  Lys Ala Ser Leu Leu  Ser Ala Pro Pro Cys  Arg Asp            
        1415                 1420                 1425                    

atc gtt atc  gaa atg gaa gac acc  aaa cca tta ctg gct  tct aag        4449
Ile Val Ile  Glu Met Glu Asp Thr  Lys Pro Leu Leu Ala  Ser Lys            
        1430                 1435                 1440                    

ctg aca gaa  aag gag gaa gaa atc  gtg gac tgg tgg agt  aaa ttt        4494
Leu Thr Glu  Lys Glu Glu Glu Ile  Val Asp Trp Trp Ser  Lys Phe            
        1445                 1450                 1455                    

tat gct tcc  tca ggg gaa cat gaa  aaa tgc gga cag tat  att cag        4539
Tyr Ala Ser  Ser Gly Glu His Glu  Lys Cys Gly Gln Tyr  Ile Gln            
        1460                 1465                 1470                    

aaa ggc tat  tcc aag ctc aag ata  tat aat tgt gaa cta  gaa aat        4584
Lys Gly Tyr  Ser Lys Leu Lys Ile  Tyr Asn Cys Glu Leu  Glu Asn            
        1475                 1480                 1485                    

gta gca gaa  ttt gag ggc ctg aca  gac ttc tca gat acg  ttc aag        4629
Val Ala Glu  Phe Glu Gly Leu Thr  Asp Phe Ser Asp Thr  Phe Lys            
        1490                 1495                 1500                    

ttg tac cga  ggc aag tcg gat gaa  aat gaa gat cct tct  gtg gtt        4674
Leu Tyr Arg  Gly Lys Ser Asp Glu  Asn Glu Asp Pro Ser  Val Val            
        1505                 1510                 1515                    

gga gag ttt  aag ggc tcc ttt cgg  atc tac cct ctg ccg  gat gac        4719
Gly Glu Phe  Lys Gly Ser Phe Arg  Ile Tyr Pro Leu Pro  Asp Asp            
        1520                 1525                 1530                    

ccc agc gtg  cca gcc cct ccc aga  cag ttt cgg gaa tta  cct gac        4764
Pro Ser Val  Pro Ala Pro Pro Arg  Gln Phe Arg Glu Leu  Pro Asp            
        1535                 1540                 1545                    

agc gtc cca  cag gaa tgc acg gtt  agg att tac att gtt  cga ggc        4809
Ser Val Pro  Gln Glu Cys Thr Val  Arg Ile Tyr Ile Val  Arg Gly            
        1550                 1555                 1560                    

tta gag ctc  cag ccc cag gac aac  aat ggc ctg tgt gac  cct tac        4854
Leu Glu Leu  Gln Pro Gln Asp Asn  Asn Gly Leu Cys Asp  Pro Tyr            
        1565                 1570                 1575                    

ata aaa ata  aca ctg ggc aaa aaa  gtc att gaa gac cga  gat cac        4899
Ile Lys Ile  Thr Leu Gly Lys Lys  Val Ile Glu Asp Arg  Asp His            
        1580                 1585                 1590                    

tac att ccc  aac act ctc aac cca  gtc ttt ggc agg atg  tac gaa        4944
Tyr Ile Pro  Asn Thr Leu Asn Pro  Val Phe Gly Arg Met  Tyr Glu            
        1595                 1600                 1605                    

ctg agc tgc  tac tta cct caa gaa  aaa gac ctg aaa att  tct gtc        4989
Leu Ser Cys  Tyr Leu Pro Gln Glu  Lys Asp Leu Lys Ile  Ser Val            
        1610                 1615                 1620                    

tat gat tat  gac acc ttt acc cgg  gat gaa aaa gta gga  gaa aca        5034
Tyr Asp Tyr  Asp Thr Phe Thr Arg  Asp Glu Lys Val Gly  Glu Thr            
        1625                 1630                 1635                    

att att gat  ctg gaa aac cga ttc  ctt tcc cgc ttt ggg  tcc cac        5079
Ile Ile Asp  Leu Glu Asn Arg Phe  Leu Ser Arg Phe Gly  Ser His            
        1640                 1645                 1650                    

tgc ggc ata  cca gag gag tac tgt  gtt tct gga gtc aat  acc tgg        5124
Cys Gly Ile  Pro Glu Glu Tyr Cys  Val Ser Gly Val Asn  Thr Trp            
        1655                 1660                 1665                    

cga gat caa  ctg aga cca aca cag  ctg ctt caa aat gtc  gcc aga        5169
Arg Asp Gln  Leu Arg Pro Thr Gln  Leu Leu Gln Asn Val  Ala Arg            
        1670                 1675                 1680                    

ttc aaa ggc  ttc cca caa ccc atc  ctt tcc gaa gat ggg  agt aga        5214
Phe Lys Gly  Phe Pro Gln Pro Ile  Leu Ser Glu Asp Gly  Ser Arg            
        1685                 1690                 1695                    

atc aga tat  gga gga cga gac tac  agc ttg gat gaa ttt  gaa gcc        5259
Ile Arg Tyr  Gly Gly Arg Asp Tyr  Ser Leu Asp Glu Phe  Glu Ala            
        1700                 1705                 1710                    

aac aaa atc  ctg cac cag cac ctc  ggg gcc cct gaa gag  cgg ctt        5304
Asn Lys Ile  Leu His Gln His Leu  Gly Ala Pro Glu Glu  Arg Leu            
        1715                 1720                 1725                    

gct ctt cac  atc ctc agg act cag  ggg ctg gtc cct gag  cac gtg        5349
Ala Leu His  Ile Leu Arg Thr Gln  Gly Leu Val Pro Glu  His Val            
        1730                 1735                 1740                    

gaa aca agg  act ttg cac agc acc  ttc cag ccc aac att  tcc cag        5394
Glu Thr Arg  Thr Leu His Ser Thr  Phe Gln Pro Asn Ile  Ser Gln            
        1745                 1750                 1755                    

gga aaa ctt  cag atg tgg gtg gat  gtt ttc ccc aag agt  ttg ggg        5439
Gly Lys Leu  Gln Met Trp Val Asp  Val Phe Pro Lys Ser  Leu Gly            
        1760                 1765                 1770                    

cca cca ggc  cct cct ttc aac atc  aca ccc cgg aaa gcc  aag aaa        5484
Pro Pro Gly  Pro Pro Phe Asn Ile  Thr Pro Arg Lys Ala  Lys Lys            
        1775                 1780                 1785                    

tac tac ctg  cgt gtg atc atc tgg  aac acc aag gac gtt  atc ttg        5529
Tyr Tyr Leu  Arg Val Ile Ile Trp  Asn Thr Lys Asp Val  Ile Leu            
        1790                 1795                 1800                    

gac gag aaa  agc atc aca gga gag  gaa atg agt gac atc  tac gtc        5574
Asp Glu Lys  Ser Ile Thr Gly Glu  Glu Met Ser Asp Ile  Tyr Val            
        1805                 1810                 1815                    

aaa ggc tgg  att cct ggc aat gaa  gaa aac aaa cag aaa  aca gat        5619
Lys Gly Trp  Ile Pro Gly Asn Glu  Glu Asn Lys Gln Lys  Thr Asp            
        1820                 1825                 1830                    

gtc cat tac  aga tct ttg gat ggt  gaa ggg aat ttt aac  tgg cga        5664
Val His Tyr  Arg Ser Leu Asp Gly  Glu Gly Asn Phe Asn  Trp Arg            
        1835                 1840                 1845                    

ttt gtt ttc  ccg ttt gac tac ctt  cca gcc gaa caa ctc  tgt atc        5709
Phe Val Phe  Pro Phe Asp Tyr Leu  Pro Ala Glu Gln Leu  Cys Ile            
        1850                 1855                 1860                    

gtt gcg aaa  aaa gag cat ttc tgg  agt att gac caa acg  gaa ttt        5754
Val Ala Lys  Lys Glu His Phe Trp  Ser Ile Asp Gln Thr  Glu Phe            
        1865                 1870                 1875                    

cga atc cca  ccc agg ctg atc att  cag ata tgg gac aat  gac aag        5799
Arg Ile Pro  Pro Arg Leu Ile Ile  Gln Ile Trp Asp Asn  Asp Lys            
        1880                 1885                 1890                    

ttt tct ctg  gat gac tac ttg ggt  ttc cta gaa ctt gac  ttg cgt        5844
Phe Ser Leu  Asp Asp Tyr Leu Gly  Phe Leu Glu Leu Asp  Leu Arg            
        1895                 1900                 1905                    

cac acg atc  att cct gca aaa tca  cca gag aaa tgc aga  ttg gac        5889
His Thr Ile  Ile Pro Ala Lys Ser  Pro Glu Lys Cys Arg  Leu Asp            
        1910                 1915                 1920                    

atg att ccg  gac ctc aaa gcc atg  aac ccc ctt aaa gcc  aag aca        5934
Met Ile Pro  Asp Leu Lys Ala Met  Asn Pro Leu Lys Ala  Lys Thr            
        1925                 1930                 1935                    

gcc tcc ctc  ttt gag cag aag tcc  atg aaa gga tgg tgg  cca tgc        5979
Ala Ser Leu  Phe Glu Gln Lys Ser  Met Lys Gly Trp Trp  Pro Cys            
        1940                 1945                 1950                    

tac gca gag  aaa gat ggc gcc cgc  gta atg gct ggg aaa  gtg gag        6024
Tyr Ala Glu  Lys Asp Gly Ala Arg  Val Met Ala Gly Lys  Val Glu            
        1955                 1960                 1965                    

atg aca ttg  gaa atc ctc aac gag  aag gag gcc gac gag  agg cca        6069
Met Thr Leu  Glu Ile Leu Asn Glu  Lys Glu Ala Asp Glu  Arg Pro            
        1970                 1975                 1980                    

gcc ggg aag  ggg cgg gac gaa ccc  aac atg aac ccc aag  ctg gac        6114
Ala Gly Lys  Gly Arg Asp Glu Pro  Asn Met Asn Pro Lys  Leu Asp            
        1985                 1990                 1995                    

tta cca aat  cga cca gaa acc tcc  ttc ctc tgg ttc acc  aac cca        6159
Leu Pro Asn  Arg Pro Glu Thr Ser  Phe Leu Trp Phe Thr  Asn Pro            
        2000                 2005                 2010                    

tgc aag acc  atg aag ttc atc gtg  tgg cgc cgc ttt aag  tgg gtc        6204
Cys Lys Thr  Met Lys Phe Ile Val  Trp Arg Arg Phe Lys  Trp Val            
        2015                 2020                 2025                    

atc atc ggc  ttg ctg ttc ctg ctt  atc ctg ctg ctc ttc  gtg gcc        6249
Ile Ile Gly  Leu Leu Phe Leu Leu  Ile Leu Leu Leu Phe  Val Ala            
        2030                 2035                 2040                    

gtg ctc ctc  tac tct ttg ccg aac  tat ttg tca atg aag  att gta        6294
Val Leu Leu  Tyr Ser Leu Pro Asn  Tyr Leu Ser Met Lys  Ile Val            
        2045                 2050                 2055                    

aag cca aat  gtg taa caaaggcaaa ggcttcattt caagagtcat ccagcaatga      6349
Lys Pro Asn  Val                                                          
        2060                                                              

gagaatcctg cctctgtaga ccaacatcca gtgtgatttt gtgtctgaga ccacacccca     6409

gtagcaggtt acgccatgtc accgagcccc attgattccc agagggtctt agtcctggaa     6469

agtcaggcca acaagcaacg tttgcatcat gttatctctt aagtattaaa agttttattt     6529

tctaaagttt aaatcatgtt tttcaaaata tttttcaagg tggctggttc catttaaaaa     6589

tcatcttttt atatgtgtct tcggttctag acttcagctt ttggaaattg ctaaatagaa     6649

ttcaaaaatc tctgcatcct gaggtgatat acttcatatt tgtaatcaac tgaaagagct     6709

gtgcattata aaatcagtta gaatagttag aacaattctt atttatgccc acaaccattg     6769

ctatattttg tatggatgtc ataaaagtct atttaacctc tgtaatgaaa ctaaataaaa     6829

atgtttcacc tttaaaaaaa aaaaaaaaaa a                                    6860


<210>  402
<211>  2061
<212>  PRT
<213>  Homo sapiens

<400>  402

Met Leu Arg Val Ile Val Glu Ser Ala Ser Asn Ile Pro Lys Thr Lys 
1               5                   10                  15      


Phe Gly Lys Pro Asp Pro Ile Val Ser Val Ile Phe Lys Asp Glu Lys 
            20                  25                  30          


Lys Lys Thr Lys Lys Val Asp Asn Glu Leu Asn Pro Val Trp Asn Glu 
        35                  40                  45              


Ile Leu Glu Phe Asp Leu Arg Gly Ile Pro Leu Asp Phe Ser Ser Ser 
    50                  55                  60                  


Leu Gly Ile Ile Val Lys Asp Phe Glu Thr Ile Gly Gln Asn Lys Leu 
65                  70                  75                  80  


Ile Gly Thr Ala Thr Val Ala Leu Lys Asp Leu Thr Gly Asp Gln Ser 
                85                  90                  95      


Arg Ser Leu Pro Tyr Lys Leu Ile Ser Leu Leu Asn Glu Lys Gly Gln 
            100                 105                 110         


Asp Thr Gly Ala Thr Ile Asp Leu Val Ile Gly Tyr Asp Pro Pro Ser 
        115                 120                 125             


Ala Pro His Pro Asn Asp Leu Ser Gly Pro Ser Val Pro Gly Met Gly 
    130                 135                 140                 


Gly Asp Gly Glu Glu Asp Glu Gly Asp Glu Asp Arg Leu Asp Asn Ala 
145                 150                 155                 160 


Val Arg Gly Pro Gly Pro Lys Gly Pro Val Gly Thr Val Ser Glu Ala 
                165                 170                 175     


Gln Leu Ala Arg Arg Leu Thr Lys Val Lys Asn Ser Arg Arg Met Leu 
            180                 185                 190         


Ser Asn Lys Pro Gln Asp Phe Gln Ile Arg Val Arg Val Ile Glu Gly 
        195                 200                 205             


Arg Gln Leu Ser Gly Asn Asn Ile Arg Pro Val Val Lys Val His Val 
    210                 215                 220                 


Cys Gly Gln Thr His Arg Thr Arg Ile Lys Arg Gly Asn Asn Pro Phe 
225                 230                 235                 240 


Phe Asp Glu Leu Phe Phe Tyr Asn Val Asn Met Thr Pro Ser Glu Leu 
                245                 250                 255     


Met Asp Glu Ile Ile Ser Ile Arg Val Tyr Asn Ser His Ser Leu Arg 
            260                 265                 270         


Ala Asp Cys Leu Met Gly Glu Phe Lys Ile Asp Val Gly Phe Val Tyr 
        275                 280                 285             


Asp Glu Pro Gly His Ala Val Met Arg Lys Trp Leu Leu Leu Asn Asp 
    290                 295                 300                 


Pro Glu Asp Thr Ser Ser Gly Ser Lys Gly Tyr Met Lys Val Ser Met 
305                 310                 315                 320 


Phe Val Leu Gly Thr Gly Asp Glu Pro Pro Pro Glu Arg Arg Asp Arg 
                325                 330                 335     


Asp Asn Asp Ser Asp Asp Val Glu Ser Asn Leu Leu Leu Pro Ala Gly 
            340                 345                 350         


Ile Ala Leu Arg Trp Val Thr Phe Leu Leu Lys Ile Tyr Arg Ala Glu 
        355                 360                 365             


Asp Ile Pro Gln Met Asp Asp Ala Phe Ser Gln Thr Val Lys Glu Ile 
    370                 375                 380                 


Phe Gly Gly Asn Ala Asp Lys Lys Asn Leu Val Asp Pro Phe Val Glu 
385                 390                 395                 400 


Val Ser Phe Ala Gly Lys Lys Val Cys Thr Asn Ile Ile Glu Lys Asn 
                405                 410                 415     


Ala Asn Pro Glu Trp Asn Gln Val Val Asn Leu Gln Ile Lys Phe Pro 
            420                 425                 430         


Ser Val Cys Glu Lys Ile Lys Leu Thr Ile Tyr Asp Trp Asp Arg Leu 
        435                 440                 445             


Thr Lys Asn Asp Val Val Gly Thr Thr Tyr Leu His Leu Ser Lys Ile 
    450                 455                 460                 


Ala Ala Ser Gly Gly Glu Val Glu Asp Phe Ser Ser Ser Gly Thr Gly 
465                 470                 475                 480 


Ala Ala Ser Tyr Thr Val Asn Thr Gly Glu Thr Glu Val Gly Phe Val 
                485                 490                 495     


Pro Thr Phe Gly Pro Cys Tyr Leu Asn Leu Tyr Gly Ser Pro Arg Glu 
            500                 505                 510         


Tyr Thr Gly Phe Pro Asp Pro Tyr Asp Glu Leu Asn Thr Gly Lys Gly 
        515                 520                 525             


Glu Gly Val Ala Tyr Arg Gly Arg Ile Leu Val Glu Leu Ala Thr Phe 
    530                 535                 540                 


Leu Glu Lys Thr Pro Pro Asp Lys Lys Leu Glu Pro Ile Ser Asn Asp 
545                 550                 555                 560 


Asp Leu Leu Val Val Glu Lys Tyr Gln Arg Arg Arg Lys Tyr Ser Leu 
                565                 570                 575     


Ser Ala Val Phe His Ser Ala Thr Met Leu Gln Asp Val Gly Glu Ala 
            580                 585                 590         


Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe Asp Thr 
        595                 600                 605             


Thr Cys Lys Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala Val Phe 
    610                 615                 620                 


Asp Gly Asn Tyr Tyr Tyr Tyr Leu Pro Trp Ala His Thr Lys Pro Val 
625                 630                 635                 640 


Val Thr Leu Thr Ser Tyr Trp Glu Asp Ile Ser His Arg Leu Asp Ala 
                645                 650                 655     


Val Asn Thr Leu Leu Ala Met Ala Glu Arg Leu Gln Thr Asn Ile Glu 
            660                 665                 670         


Ala Leu Lys Ser Gly Ile Gln Gly Lys Ile Pro Ala Asn Gln Leu Ala 
        675                 680                 685             


Glu Leu Trp Leu Lys Leu Ile Asp Glu Val Ile Glu Asp Thr Arg Tyr 
    690                 695                 700                 


Thr Leu Pro Leu Thr Glu Gly Lys Ala Asn Val Thr Val Leu Asp Thr 
705                 710                 715                 720 


Gln Ile Arg Lys Leu Arg Ser Arg Ser Leu Ser Gln Ile His Glu Ala 
                725                 730                 735     


Ala Val Arg Met Arg Ser Glu Ala Thr Asp Val Lys Ser Thr Leu Ala 
            740                 745                 750         


Glu Ile Glu Asp Trp Leu Asp Lys Leu Met Gln Leu Thr Glu Glu Pro 
        755                 760                 765             


Gln Asn Ser Met Pro Asp Ile Ile Ile Trp Met Ile Arg Gly Glu Lys 
    770                 775                 780                 


Arg Leu Ala Tyr Ala Arg Ile Pro Ala His Gln Val Leu Tyr Ser Thr 
785                 790                 795                 800 


Ser Gly Glu Asn Ala Ser Gly Lys Tyr Cys Gly Lys Thr Gln Thr Ile 
                805                 810                 815     


Phe Leu Lys Tyr Pro Gln Glu Lys Asn Asn Gly Pro Lys Val Pro Val 
            820                 825                 830         


Glu Leu Arg Val Asn Ile Trp Leu Gly Leu Ser Ala Val Glu Lys Lys 
        835                 840                 845             


Phe Asn Ser Phe Ala Glu Gly Thr Phe Thr Val Phe Ala Glu Met Tyr 
    850                 855                 860                 


Glu Asn Gln Ala Leu Met Phe Gly Lys Trp Gly Thr Ser Gly Leu Val 
865                 870                 875                 880 


Gly Arg His Lys Phe Ser Asp Val Thr Gly Lys Ile Lys Leu Lys Arg 
                885                 890                 895     


Glu Phe Phe Leu Pro Pro Lys Gly Trp Glu Trp Glu Gly Glu Trp Ile 
            900                 905                 910         


Val Asp Pro Glu Arg Ser Leu Leu Thr Glu Ala Asp Ala Gly His Thr 
        915                 920                 925             


Glu Phe Thr Asp Glu Val Tyr Gln Asn Glu Ser Arg Tyr Pro Gly Gly 
    930                 935                 940                 


Asp Trp Lys Pro Ala Glu Asp Thr Tyr Thr Asp Ala Asn Gly Asp Lys 
945                 950                 955                 960 


Ala Ala Ser Pro Ser Glu Leu Thr Cys Pro Pro Gly Trp Glu Trp Glu 
                965                 970                 975     


Asp Asp Ala Trp Ser Tyr Asp Ile Asn Arg Ala Val Asp Glu Lys Gly 
            980                 985                 990         


Trp Glu Tyr Gly Ile Thr Ile Pro  Pro Asp His Lys Pro  Lys Ser Trp 
        995                 1000                 1005             


Val Ala  Ala Glu Lys Met Tyr  His Thr His Arg Arg  Arg Arg Leu 
    1010                 1015                 1020             


Val Arg  Lys Arg Lys Lys Asp  Leu Thr Gln Thr Ala  Ser Ser Thr 
    1025                 1030                 1035             


Ala Arg  Ala Met Glu Glu Leu  Gln Asp Gln Glu Gly  Trp Glu Tyr 
    1040                 1045                 1050             


Ala Ser  Leu Ile Gly Trp Lys  Phe His Trp Lys Gln  Arg Ser Ser 
    1055                 1060                 1065             


Asp Thr  Phe Arg Arg Arg Arg  Trp Arg Arg Lys Met  Ala Pro Ser 
    1070                 1075                 1080             


Glu Thr  His Gly Ala Ala Ala  Ile Phe Lys Leu Glu  Gly Ala Leu 
    1085                 1090                 1095             


Gly Ala  Asp Thr Thr Glu Asp  Gly Asp Glu Lys Ser  Leu Glu Lys 
    1100                 1105                 1110             


Gln Lys  His Ser Ala Thr Thr  Val Phe Gly Ala Asn  Thr Pro Ile 
    1115                 1120                 1125             


Val Ser  Cys Asn Phe Asp Arg  Val Tyr Ile Tyr His  Leu Arg Cys 
    1130                 1135                 1140             


Tyr Val  Tyr Gln Ala Arg Asn  Leu Leu Ala Leu Asp  Lys Asp Ser 
    1145                 1150                 1155             


Phe Ser  Asp Pro Tyr Ala His  Ile Cys Phe Leu His  Arg Ser Lys 
    1160                 1165                 1170             


Thr Thr  Glu Ile Ile His Ser  Thr Leu Asn Pro Thr  Trp Asp Gln 
    1175                 1180                 1185             


Thr Ile  Ile Phe Asp Glu Val  Glu Ile Tyr Gly Glu  Pro Gln Thr 
    1190                 1195                 1200             


Val Leu  Gln Asn Pro Pro Lys  Val Ile Met Glu Leu  Phe Asp Asn 
    1205                 1210                 1215             


Asp Gln  Val Gly Lys Asp Glu  Phe Leu Gly Arg Ser  Ile Phe Ser 
    1220                 1225                 1230             


Pro Val  Val Lys Leu Asn Ser  Glu Met Asp Ile Thr  Pro Lys Leu 
    1235                 1240                 1245             


Leu Trp  His Pro Val Met Asn  Gly Asp Lys Ala Cys  Gly Asp Val 
    1250                 1255                 1260             


Leu Val  Thr Ala Glu Leu Ile  Leu Arg Gly Lys Asp  Gly Ser Asn 
    1265                 1270                 1275             


Leu Pro  Ile Leu Pro Pro Gln  Arg Ala Pro Asn Leu  Tyr Met Val 
    1280                 1285                 1290             


Pro Gln  Gly Ile Arg Pro Val  Val Gln Leu Thr Ala  Ile Glu Ile 
    1295                 1300                 1305             


Leu Ala  Trp Gly Leu Arg Asn  Met Lys Asn Phe Gln  Met Ala Ser 
    1310                 1315                 1320             


Ile Thr  Ser Pro Ser Leu Val  Val Glu Cys Gly Gly  Glu Arg Val 
    1325                 1330                 1335             


Glu Ser  Val Val Ile Lys Asn  Leu Lys Lys Thr Pro  Asn Phe Pro 
    1340                 1345                 1350             


Ser Ser  Val Leu Phe Met Lys  Val Phe Leu Pro Lys  Glu Glu Leu 
    1355                 1360                 1365             


Tyr Met  Pro Pro Leu Val Ile  Lys Val Ile Asp His  Arg Gln Phe 
    1370                 1375                 1380             


Gly Arg  Lys Pro Val Val Gly  Gln Cys Thr Ile Glu  Arg Leu Asp 
    1385                 1390                 1395             


Arg Phe  Arg Cys Asp Pro Tyr  Ala Gly Lys Glu Asp  Ile Val Pro 
    1400                 1405                 1410             


Gln Leu  Lys Ala Ser Leu Leu  Ser Ala Pro Pro Cys  Arg Asp Ile 
    1415                 1420                 1425             


Val Ile  Glu Met Glu Asp Thr  Lys Pro Leu Leu Ala  Ser Lys Leu 
    1430                 1435                 1440             


Thr Glu  Lys Glu Glu Glu Ile  Val Asp Trp Trp Ser  Lys Phe Tyr 
    1445                 1450                 1455             


Ala Ser  Ser Gly Glu His Glu  Lys Cys Gly Gln Tyr  Ile Gln Lys 
    1460                 1465                 1470             


Gly Tyr  Ser Lys Leu Lys Ile  Tyr Asn Cys Glu Leu  Glu Asn Val 
    1475                 1480                 1485             


Ala Glu  Phe Glu Gly Leu Thr  Asp Phe Ser Asp Thr  Phe Lys Leu 
    1490                 1495                 1500             


Tyr Arg  Gly Lys Ser Asp Glu  Asn Glu Asp Pro Ser  Val Val Gly 
    1505                 1510                 1515             


Glu Phe  Lys Gly Ser Phe Arg  Ile Tyr Pro Leu Pro  Asp Asp Pro 
    1520                 1525                 1530             


Ser Val  Pro Ala Pro Pro Arg  Gln Phe Arg Glu Leu  Pro Asp Ser 
    1535                 1540                 1545             


Val Pro  Gln Glu Cys Thr Val  Arg Ile Tyr Ile Val  Arg Gly Leu 
    1550                 1555                 1560             


Glu Leu  Gln Pro Gln Asp Asn  Asn Gly Leu Cys Asp  Pro Tyr Ile 
    1565                 1570                 1575             


Lys Ile  Thr Leu Gly Lys Lys  Val Ile Glu Asp Arg  Asp His Tyr 
    1580                 1585                 1590             


Ile Pro  Asn Thr Leu Asn Pro  Val Phe Gly Arg Met  Tyr Glu Leu 
    1595                 1600                 1605             


Ser Cys  Tyr Leu Pro Gln Glu  Lys Asp Leu Lys Ile  Ser Val Tyr 
    1610                 1615                 1620             


Asp Tyr  Asp Thr Phe Thr Arg  Asp Glu Lys Val Gly  Glu Thr Ile 
    1625                 1630                 1635             


Ile Asp  Leu Glu Asn Arg Phe  Leu Ser Arg Phe Gly  Ser His Cys 
    1640                 1645                 1650             


Gly Ile  Pro Glu Glu Tyr Cys  Val Ser Gly Val Asn  Thr Trp Arg 
    1655                 1660                 1665             


Asp Gln  Leu Arg Pro Thr Gln  Leu Leu Gln Asn Val  Ala Arg Phe 
    1670                 1675                 1680             


Lys Gly  Phe Pro Gln Pro Ile  Leu Ser Glu Asp Gly  Ser Arg Ile 
    1685                 1690                 1695             


Arg Tyr  Gly Gly Arg Asp Tyr  Ser Leu Asp Glu Phe  Glu Ala Asn 
    1700                 1705                 1710             


Lys Ile  Leu His Gln His Leu  Gly Ala Pro Glu Glu  Arg Leu Ala 
    1715                 1720                 1725             


Leu His  Ile Leu Arg Thr Gln  Gly Leu Val Pro Glu  His Val Glu 
    1730                 1735                 1740             


Thr Arg  Thr Leu His Ser Thr  Phe Gln Pro Asn Ile  Ser Gln Gly 
    1745                 1750                 1755             


Lys Leu  Gln Met Trp Val Asp  Val Phe Pro Lys Ser  Leu Gly Pro 
    1760                 1765                 1770             


Pro Gly  Pro Pro Phe Asn Ile  Thr Pro Arg Lys Ala  Lys Lys Tyr 
    1775                 1780                 1785             


Tyr Leu  Arg Val Ile Ile Trp  Asn Thr Lys Asp Val  Ile Leu Asp 
    1790                 1795                 1800             


Glu Lys  Ser Ile Thr Gly Glu  Glu Met Ser Asp Ile  Tyr Val Lys 
    1805                 1810                 1815             


Gly Trp  Ile Pro Gly Asn Glu  Glu Asn Lys Gln Lys  Thr Asp Val 
    1820                 1825                 1830             


His Tyr  Arg Ser Leu Asp Gly  Glu Gly Asn Phe Asn  Trp Arg Phe 
    1835                 1840                 1845             


Val Phe  Pro Phe Asp Tyr Leu  Pro Ala Glu Gln Leu  Cys Ile Val 
    1850                 1855                 1860             


Ala Lys  Lys Glu His Phe Trp  Ser Ile Asp Gln Thr  Glu Phe Arg 
    1865                 1870                 1875             


Ile Pro  Pro Arg Leu Ile Ile  Gln Ile Trp Asp Asn  Asp Lys Phe 
    1880                 1885                 1890             


Ser Leu  Asp Asp Tyr Leu Gly  Phe Leu Glu Leu Asp  Leu Arg His 
    1895                 1900                 1905             


Thr Ile  Ile Pro Ala Lys Ser  Pro Glu Lys Cys Arg  Leu Asp Met 
    1910                 1915                 1920             


Ile Pro  Asp Leu Lys Ala Met  Asn Pro Leu Lys Ala  Lys Thr Ala 
    1925                 1930                 1935             


Ser Leu  Phe Glu Gln Lys Ser  Met Lys Gly Trp Trp  Pro Cys Tyr 
    1940                 1945                 1950             


Ala Glu  Lys Asp Gly Ala Arg  Val Met Ala Gly Lys  Val Glu Met 
    1955                 1960                 1965             


Thr Leu  Glu Ile Leu Asn Glu  Lys Glu Ala Asp Glu  Arg Pro Ala 
    1970                 1975                 1980             


Gly Lys  Gly Arg Asp Glu Pro  Asn Met Asn Pro Lys  Leu Asp Leu 
    1985                 1990                 1995             


Pro Asn  Arg Pro Glu Thr Ser  Phe Leu Trp Phe Thr  Asn Pro Cys 
    2000                 2005                 2010             


Lys Thr  Met Lys Phe Ile Val  Trp Arg Arg Phe Lys  Trp Val Ile 
    2015                 2020                 2025             


Ile Gly  Leu Leu Phe Leu Leu  Ile Leu Leu Leu Phe  Val Ala Val 
    2030                 2035                 2040             


Leu Leu  Tyr Ser Leu Pro Asn  Tyr Leu Ser Met Lys  Ile Val Lys 
    2045                 2050                 2055             


Pro Asn  Val 
    2060     


<210>  403
<211>  7762
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (143)..(5647)

<400>  403
gcggccgcgg aggcggaggc agccgcggag gcggaggcgg ccggcggggg gtggcgaggg       60

gcgccgggcc cccgcggacc tgtcgtcctc ggcccgtcct ccggccccgg ccccgcgcgg      120

ctgaggaggc gcggccagga cc atg tcg gcg ggc ggc cgt gac gag gag cgg       172
                         Met Ser Ala Gly Gly Arg Asp Glu Glu Arg          
                         1               5                   10           

cgg aag ctg gcc gac atc atc cac cac tgg aac gcc aac cgg ctg gac        220
Arg Lys Leu Ala Asp Ile Ile His His Trp Asn Ala Asn Arg Leu Asp           
                15                  20                  25                

ctg ttc gag atc agc cag ccg acc gag gat ttg gag ttc cat gga gtg        268
Leu Phe Glu Ile Ser Gln Pro Thr Glu Asp Leu Glu Phe His Gly Val           
            30                  35                  40                    

atg aga ttt tat ttt caa gat aaa gct gct gga aac ttt gca aca aaa        316
Met Arg Phe Tyr Phe Gln Asp Lys Ala Ala Gly Asn Phe Ala Thr Lys           
        45                  50                  55                        

tgt att cgg gtc tct agt act gcc acc act caa gat gta atc gaa acg        364
Cys Ile Arg Val Ser Ser Thr Ala Thr Thr Gln Asp Val Ile Glu Thr           
    60                  65                  70                            

ctc gcg gag aaa ttt cga cct gat atg cga atg ctg tcc tct ccc aag        412
Leu Ala Glu Lys Phe Arg Pro Asp Met Arg Met Leu Ser Ser Pro Lys           
75                  80                  85                  90            

tat tca ctc tat gaa gtg cat gtc agc gga gaa aga aga ttg gat ata        460
Tyr Ser Leu Tyr Glu Val His Val Ser Gly Glu Arg Arg Leu Asp Ile           
                95                  100                 105               

gat gag aaa cct cta gtt gta caa ctg aat tgg aac aaa gat gat cgg        508
Asp Glu Lys Pro Leu Val Val Gln Leu Asn Trp Asn Lys Asp Asp Arg           
            110                 115                 120                   

gaa ggc aga ttt gtt ctt aag aat gag aat gac gcc att cct cct aag        556
Glu Gly Arg Phe Val Leu Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys           
        125                 130                 135                       

gct caa agt aat gga cct gaa aag cag gaa aaa gaa ggg gtt atc cag        604
Ala Gln Ser Asn Gly Pro Glu Lys Gln Glu Lys Glu Gly Val Ile Gln           
    140                 145                 150                           

aac ttc aag aga act ctc tca aag aaa gaa aag aag gaa aaa aag aag        652
Asn Phe Lys Arg Thr Leu Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys           
155                 160                 165                 170           

aga gaa aaa gag gca ttg cga cag gca tct gat aaa gat gat aga cct        700
Arg Glu Lys Glu Ala Leu Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro           
                175                 180                 185               

ttc caa ggg gag gat gtt gaa aat tct cga ctg gct gct gag gtt tac        748
Phe Gln Gly Glu Asp Val Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr           
            190                 195                 200                   

aaa gac atg ccg gaa acc agc ttt act cga acc att tct aat cct gag        796
Lys Asp Met Pro Glu Thr Ser Phe Thr Arg Thr Ile Ser Asn Pro Glu           
        205                 210                 215                       

gtg gtt atg aaa cga cgg agg cag caa aaa ttg gaa aag aga atg cag        844
Val Val Met Lys Arg Arg Arg Gln Gln Lys Leu Glu Lys Arg Met Gln           
    220                 225                 230                           

gaa ttt cgg agc tca gat ggg cgg cct gat tca ggt gga aca ttg aga        892
Glu Phe Arg Ser Ser Asp Gly Arg Pro Asp Ser Gly Gly Thr Leu Arg           
235                 240                 245                 250           

att tat gca gat agt tta aaa cca aat att ccc tac aag aca atc ctg        940
Ile Tyr Ala Asp Ser Leu Lys Pro Asn Ile Pro Tyr Lys Thr Ile Leu           
                255                 260                 265               

ctg tct act aca gat cct gca gac ttt gct gtg gct gaa gct tta gag        988
Leu Ser Thr Thr Asp Pro Ala Asp Phe Ala Val Ala Glu Ala Leu Glu           
            270                 275                 280                   

aag tat ggt ctg gaa aaa gaa aac cct aag gat tac tgc atc gcc cgg       1036
Lys Tyr Gly Leu Glu Lys Glu Asn Pro Lys Asp Tyr Cys Ile Ala Arg           
        285                 290                 295                       

gtt atg ctt cct cct gga gcc cag cat tct gat gaa aag ggt gct aaa       1084
Val Met Leu Pro Pro Gly Ala Gln His Ser Asp Glu Lys Gly Ala Lys           
    300                 305                 310                           

gaa att att ctt gat gat gat gag tgt cct tta caa atc ttc agg gaa       1132
Glu Ile Ile Leu Asp Asp Asp Glu Cys Pro Leu Gln Ile Phe Arg Glu           
315                 320                 325                 330           

tgg cca agt gac aaa ggg att tta gtc ttt cag ttg aag agg agg cca       1180
Trp Pro Ser Asp Lys Gly Ile Leu Val Phe Gln Leu Lys Arg Arg Pro           
                335                 340                 345               

cca gac cac atc cca aag aaa acc aag aaa cac ttg gaa ggc aag aca       1228
Pro Asp His Ile Pro Lys Lys Thr Lys Lys His Leu Glu Gly Lys Thr           
            350                 355                 360                   

ccc aag gga aag gag aga gct gac ggg tct ggc tat ggc tcc acc ctt       1276
Pro Lys Gly Lys Glu Arg Ala Asp Gly Ser Gly Tyr Gly Ser Thr Leu           
        365                 370                 375                       

cct ccg gag aag ctg ccc tat tta gta gag tta agc cca ggg aga agg       1324
Pro Pro Glu Lys Leu Pro Tyr Leu Val Glu Leu Ser Pro Gly Arg Arg           
    380                 385                 390                           

aat cac ttt gcc tac tac aac tat cac act tac gaa gat ggt tct gac       1372
Asn His Phe Ala Tyr Tyr Asn Tyr His Thr Tyr Glu Asp Gly Ser Asp           
395                 400                 405                 410           

tct aga gat aag cca aag ctt tac cgc ctt cag tta agt gtt act gaa       1420
Ser Arg Asp Lys Pro Lys Leu Tyr Arg Leu Gln Leu Ser Val Thr Glu           
                415                 420                 425               

gtt ggg aca gaa aag ttg gat gac aac tct atc cag ttg ttt ggc cca       1468
Val Gly Thr Glu Lys Leu Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro           
            430                 435                 440                   

gga att cag ccc cat cac tgt gac ctt acc aac atg gat gga gtg gtc       1516
Gly Ile Gln Pro His His Cys Asp Leu Thr Asn Met Asp Gly Val Val           
        445                 450                 455                       

act gtg acg ccc aga agt atg gac gca gaa acc tac gtg gaa ggc cag       1564
Thr Val Thr Pro Arg Ser Met Asp Ala Glu Thr Tyr Val Glu Gly Gln           
    460                 465                 470                           

cgc atc tca gaa acc acc atg ctg cag agt ggc atg aaa gtg cag ttt       1612
Arg Ile Ser Glu Thr Thr Met Leu Gln Ser Gly Met Lys Val Gln Phe           
475                 480                 485                 490           

ggg gcg tcc cat gta ttt aag ttt gtg gac ccc agt cag gat cat gct       1660
Gly Ala Ser His Val Phe Lys Phe Val Asp Pro Ser Gln Asp His Ala           
                495                 500                 505               

ctt gca aaa aga tct gtg gat gga ggc ctg atg gtt aag ggc cca aga       1708
Leu Ala Lys Arg Ser Val Asp Gly Gly Leu Met Val Lys Gly Pro Arg           
            510                 515                 520                   

cat aaa cct gga att gtt cag gag aca act ttt gat ttg gga gga gat       1756
His Lys Pro Gly Ile Val Gln Glu Thr Thr Phe Asp Leu Gly Gly Asp           
        525                 530                 535                       

att cat agt ggg aca gca tta ccg aca agc aag agc acc act agg ctg       1804
Ile His Ser Gly Thr Ala Leu Pro Thr Ser Lys Ser Thr Thr Arg Leu           
    540                 545                 550                           

gac agc gac aga gtg tcg tct gcc tct agc aca gcc gag cgg gga atg       1852
Asp Ser Asp Arg Val Ser Ser Ala Ser Ser Thr Ala Glu Arg Gly Met           
555                 560                 565                 570           

gtg aag ccg atg atc aga gta gaa cag cag cca gat tat cgc agg caa       1900
Val Lys Pro Met Ile Arg Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln           
                575                 580                 585               

gaa agc aga aca cag gat gct tct ggg cct gag ctg ata cta cct gca       1948
Glu Ser Arg Thr Gln Asp Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala           
            590                 595                 600                   

agc att gaa ttc agg gaa agt tct gaa gat tca ttt ttg tct gcc att       1996
Ser Ile Glu Phe Arg Glu Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile           
        605                 610                 615                       

ata aat tat act aat agc tct aca gtc cac ttt aag ttg tcc cct aca       2044
Ile Asn Tyr Thr Asn Ser Ser Thr Val His Phe Lys Leu Ser Pro Thr           
    620                 625                 630                           

tat gta tta tat atg gca tgc cgg tat gta ttg tcc aac cag tac aga       2092
Tyr Val Leu Tyr Met Ala Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg           
635                 640                 645                 650           

cct gac atc agc cct aca gag cgc aca cat aaa gtc att gca gtc gtc       2140
Pro Asp Ile Ser Pro Thr Glu Arg Thr His Lys Val Ile Ala Val Val           
                655                 660                 665               

aac aag atg gtg agc atg atg gag ggt gtc atc cag aaa cag aag aat       2188
Asn Lys Met Val Ser Met Met Glu Gly Val Ile Gln Lys Gln Lys Asn           
            670                 675                 680                   

att gca ggg gca ctt gcc ttc tgg atg gca aat gca tct gaa ctt ctc       2236
Ile Ala Gly Ala Leu Ala Phe Trp Met Ala Asn Ala Ser Glu Leu Leu           
        685                 690                 695                       

aac ttc att aag caa gac cga gac ctt agt cgg atc aca ctg gat gct       2284
Asn Phe Ile Lys Gln Asp Arg Asp Leu Ser Arg Ile Thr Leu Asp Ala           
    700                 705                 710                           

caa gat gtt tta gca cat ttg gtt caa atg gca ttt aaa tac ttg gtt       2332
Gln Asp Val Leu Ala His Leu Val Gln Met Ala Phe Lys Tyr Leu Val           
715                 720                 725                 730           

cac tgt ctt caa tca gaa ctt aat aat tac atg cca gcc ttt cta gat       2380
His Cys Leu Gln Ser Glu Leu Asn Asn Tyr Met Pro Ala Phe Leu Asp           
                735                 740                 745               

gac cct gaa gag aac agt ctg caa cga cca aaa ata gat gat gtg ctg       2428
Asp Pro Glu Glu Asn Ser Leu Gln Arg Pro Lys Ile Asp Asp Val Leu           
            750                 755                 760                   

cac acg ctc aca gga gcc atg tcc ttg cta cga cgc tgc aga gtc aat       2476
His Thr Leu Thr Gly Ala Met Ser Leu Leu Arg Arg Cys Arg Val Asn           
        765                 770                 775                       

gcc gcc ctg acc atc cag ctc ttc tct cag ctc ttc cac ttc atc aat       2524
Ala Ala Leu Thr Ile Gln Leu Phe Ser Gln Leu Phe His Phe Ile Asn           
    780                 785                 790                           

atg tgg ctg ttc aat aga ttg gtg acc gac cca gat tcg ggg ctg tgc       2572
Met Trp Leu Phe Asn Arg Leu Val Thr Asp Pro Asp Ser Gly Leu Cys           
795                 800                 805                 810           

tcc cat tac tgg ggt gcg att atc cgt cag cag ttg ggc cat att gaa       2620
Ser His Tyr Trp Gly Ala Ile Ile Arg Gln Gln Leu Gly His Ile Glu           
                815                 820                 825               

gcc tgg gct gag aag cag ggg ctg gaa ctg gct gcg gac tgt cat ctg       2668
Ala Trp Ala Glu Lys Gln Gly Leu Glu Leu Ala Ala Asp Cys His Leu           
            830                 835                 840                   

agc agg atc gtg cag gca acg act ttg ctt acc atg gat aag tat gca       2716
Ser Arg Ile Val Gln Ala Thr Thr Leu Leu Thr Met Asp Lys Tyr Ala           
        845                 850                 855                       

cct gat gac att cca aat ata aac agc acc tgc ttt aag tta aat tca       2764
Pro Asp Asp Ile Pro Asn Ile Asn Ser Thr Cys Phe Lys Leu Asn Ser           
    860                 865                 870                           

tta caa ctt caa gcc tta tta cag aac tat cac tgt gca cct gat gag       2812
Leu Gln Leu Gln Ala Leu Leu Gln Asn Tyr His Cys Ala Pro Asp Glu           
875                 880                 885                 890           

cct ttt atc cca acg gat ctt ata gaa aat gta gtg act gtg gct gaa       2860
Pro Phe Ile Pro Thr Asp Leu Ile Glu Asn Val Val Thr Val Ala Glu           
                895                 900                 905               

aac act gcc gat gag ctg gcc cgc agt gat gga agg gaa gtg cag ttg       2908
Asn Thr Ala Asp Glu Leu Ala Arg Ser Asp Gly Arg Glu Val Gln Leu           
            910                 915                 920                   

gag gag gat cct gat ctg cag ctg ccg ttt ctt ttg cca gaa gat ggt       2956
Glu Glu Asp Pro Asp Leu Gln Leu Pro Phe Leu Leu Pro Glu Asp Gly           
        925                 930                 935                       

tat tct tgt gat gtt gtc aga aac att cca aat ggt tta caa gaa ttt       3004
Tyr Ser Cys Asp Val Val Arg Asn Ile Pro Asn Gly Leu Gln Glu Phe           
    940                 945                 950                           

tta gac cct ctg tgc cag aga gga ttt tgc agg tta att cct cac aca       3052
Leu Asp Pro Leu Cys Gln Arg Gly Phe Cys Arg Leu Ile Pro His Thr           
955                 960                 965                 970           

cgt tca cca ggt act tgg aca ata tat ttt gaa ggt gca gat tat gaa       3100
Arg Ser Pro Gly Thr Trp Thr Ile Tyr Phe Glu Gly Ala Asp Tyr Glu           
                975                 980                 985               

agt cac ctt ctg cgt gag aac aca gag ctg gct cag cct ctg  agg aaa      3148
Ser His Leu Leu Arg Glu Asn Thr Glu Leu Ala Gln Pro Leu  Arg Lys          
            990                 995                 1000                  

gaa cct gaa  ata atc act gtg acc  cta aaa aag cag aat  gga atg        3193
Glu Pro Glu  Ile Ile Thr Val Thr  Leu Lys Lys Gln Asn  Gly Met            
        1005                 1010                 1015                    

ggc ctt agc  att gtt gca gca aag  ggt gct ggt caa gat  aaa cta        3238
Gly Leu Ser  Ile Val Ala Ala Lys  Gly Ala Gly Gln Asp  Lys Leu            
        1020                 1025                 1030                    

gga atc tat  gtg aag tcg gtt gtg  aaa gga ggt gct gca  gat gtg        3283
Gly Ile Tyr  Val Lys Ser Val Val  Lys Gly Gly Ala Ala  Asp Val            
        1035                 1040                 1045                    

gat gga cgt  cta gct gca ggt gat  cag ctc ctc agt gtg  gat gga        3328
Asp Gly Arg  Leu Ala Ala Gly Asp  Gln Leu Leu Ser Val  Asp Gly            
        1050                 1055                 1060                    

cga agt ctg  gtt gga ctc tct cag  gaa agg gcg gca gaa  ctc atg        3373
Arg Ser Leu  Val Gly Leu Ser Gln  Glu Arg Ala Ala Glu  Leu Met            
        1065                 1070                 1075                    

aca aga aca  agc tct gtg gtg aca  ctg gaa gta gca aag  cag ggt        3418
Thr Arg Thr  Ser Ser Val Val Thr  Leu Glu Val Ala Lys  Gln Gly            
        1080                 1085                 1090                    

gcc atc tac  cac ggt ctg gcc acc  ctt ctc aat cag cca  tcc ccc        3463
Ala Ile Tyr  His Gly Leu Ala Thr  Leu Leu Asn Gln Pro  Ser Pro            
        1095                 1100                 1105                    

atg atg cag  aga att tca gat cgt  cgt ggc tca ggt aaa  ccc cga        3508
Met Met Gln  Arg Ile Ser Asp Arg  Arg Gly Ser Gly Lys  Pro Arg            
        1110                 1115                 1120                    

cca aag agt  gaa ggc ttt gag ctc  tat aat aat tca act  caa aat        3553
Pro Lys Ser  Glu Gly Phe Glu Leu  Tyr Asn Asn Ser Thr  Gln Asn            
        1125                 1130                 1135                    

ggg tct cct  gag agt cct cag ctg  cct tgg gca gaa tat  agt gaa        3598
Gly Ser Pro  Glu Ser Pro Gln Leu  Pro Trp Ala Glu Tyr  Ser Glu            
        1140                 1145                 1150                    

cca aag aaa  ttg cct ggt gat gac  aga ctg atg aaa aat  aga gct        3643
Pro Lys Lys  Leu Pro Gly Asp Asp  Arg Leu Met Lys Asn  Arg Ala            
        1155                 1160                 1165                    

gat cac cgt  tcc agc ccc aac gta  gca aat cag cct cct  agt cct        3688
Asp His Arg  Ser Ser Pro Asn Val  Ala Asn Gln Pro Pro  Ser Pro            
        1170                 1175                 1180                    

gga ggg aaa  agt gca tat gcc tct  gga aca aca gcg aag  ata aca        3733
Gly Gly Lys  Ser Ala Tyr Ala Ser  Gly Thr Thr Ala Lys  Ile Thr            
        1185                 1190                 1195                    

tct gtc tct  act gga aac ctc tgc  act gag gag cag acg  cct ccg        3778
Ser Val Ser  Thr Gly Asn Leu Cys  Thr Glu Glu Gln Thr  Pro Pro            
        1200                 1205                 1210                    

cct aga cct  gaa gcc tac ccc atc  ccc act cag acg tac  acc aga        3823
Pro Arg Pro  Glu Ala Tyr Pro Ile  Pro Thr Gln Thr Tyr  Thr Arg            
        1215                 1220                 1225                    

gag tat ttt  acc ttc cca gct tcc  aaa tcc cag gat cgg  atg gct        3868
Glu Tyr Phe  Thr Phe Pro Ala Ser  Lys Ser Gln Asp Arg  Met Ala            
        1230                 1235                 1240                    

cct cct cag  aac cag tgg cca aat  tat gag gaa aag cca  cat atg        3913
Pro Pro Gln  Asn Gln Trp Pro Asn  Tyr Glu Glu Lys Pro  His Met            
        1245                 1250                 1255                    

cac aca gat  agt aat cat tcc agt  att gca att cag cgt  gtt aca        3958
His Thr Asp  Ser Asn His Ser Ser  Ile Ala Ile Gln Arg  Val Thr            
        1260                 1265                 1270                    

cgt tcc caa  gaa gaa ctt cga gaa  gat aaa gct tac caa  ctt gag        4003
Arg Ser Gln  Glu Glu Leu Arg Glu  Asp Lys Ala Tyr Gln  Leu Glu            
        1275                 1280                 1285                    

cgg cat cga  ata gag gca gct atg  gac cga aag tct gat  agt gat        4048
Arg His Arg  Ile Glu Ala Ala Met  Asp Arg Lys Ser Asp  Ser Asp            
        1290                 1295                 1300                    

atg tgg ata  aat cag agc tcc tca  ctg gac tcc agt acc  tct agc        4093
Met Trp Ile  Asn Gln Ser Ser Ser  Leu Asp Ser Ser Thr  Ser Ser            
        1305                 1310                 1315                    

cag gag cat  ctg aac cat tcc tct  aag tcg gtc acc cct  gct tcc        4138
Gln Glu His  Leu Asn His Ser Ser  Lys Ser Val Thr Pro  Ala Ser            
        1320                 1325                 1330                    

aca ctg acc  aaa agt ggc cct ggc  cgt tgg aaa aca cca  gca gcc        4183
Thr Leu Thr  Lys Ser Gly Pro Gly  Arg Trp Lys Thr Pro  Ala Ala            
        1335                 1340                 1345                    

ata ccg gcc  acc cct gtg gcc gtc  tcc cag cca atc cga  aca gac        4228
Ile Pro Ala  Thr Pro Val Ala Val  Ser Gln Pro Ile Arg  Thr Asp            
        1350                 1355                 1360                    

ctg cct ccg  cca ccc ccg cca cct  cca gtc cac tat gcc  ggt gat        4273
Leu Pro Pro  Pro Pro Pro Pro Pro  Pro Val His Tyr Ala  Gly Asp            
        1365                 1370                 1375                    

ttc gat gga  atg tcc atg gat ttg  cct ctc cca cca ccc  cct tcc        4318
Phe Asp Gly  Met Ser Met Asp Leu  Pro Leu Pro Pro Pro  Pro Ser            
        1380                 1385                 1390                    

gcc aac cag  ata ggg ctg ccg tct  gcg cag gtg gct gct  gct gaa        4363
Ala Asn Gln  Ile Gly Leu Pro Ser  Ala Gln Val Ala Ala  Ala Glu            
        1395                 1400                 1405                    

cgg aga aag  aga gaa gaa cat cag  cgt tgg tat gag aag  gag aag        4408
Arg Arg Lys  Arg Glu Glu His Gln  Arg Trp Tyr Glu Lys  Glu Lys            
        1410                 1415                 1420                    

gcc cgc ctg  gag gag gag cgg gag  agg aag cgg aga gag  cag gag        4453
Ala Arg Leu  Glu Glu Glu Arg Glu  Arg Lys Arg Arg Glu  Gln Glu            
        1425                 1430                 1435                    

agg aag ttg  ggc cag atg cgc act  cag tcc tta aac cct  gct ccg        4498
Arg Lys Leu  Gly Gln Met Arg Thr  Gln Ser Leu Asn Pro  Ala Pro            
        1440                 1445                 1450                    

ttt tct ccc  ctg act gca cag cag  atg aag ccc gaa aag  cct tcc        4543
Phe Ser Pro  Leu Thr Ala Gln Gln  Met Lys Pro Glu Lys  Pro Ser            
        1455                 1460                 1465                    

aca ctc cag  cgg cca cag gaa aca  gtc att cgg gag ctg  cag cct        4588
Thr Leu Gln  Arg Pro Gln Glu Thr  Val Ile Arg Glu Leu  Gln Pro            
        1470                 1475                 1480                    

cag cag cag  ccc cgc acg atc gag  cgc aga gac ttg cag  tac att        4633
Gln Gln Gln  Pro Arg Thr Ile Glu  Arg Arg Asp Leu Gln  Tyr Ile            
        1485                 1490                 1495                    

aca gtc agc  aaa gag gag ctt tcc  tcg ggg gac agt ctg  tcc ccc        4678
Thr Val Ser  Lys Glu Glu Leu Ser  Ser Gly Asp Ser Leu  Ser Pro            
        1500                 1505                 1510                    

gac ccg tgg  aag cgg gac gcc aag  gag aag ctg gag aag  cag cag        4723
Asp Pro Trp  Lys Arg Asp Ala Lys  Glu Lys Leu Glu Lys  Gln Gln            
        1515                 1520                 1525                    

cag atg cac  atc gtg gac atg ctg  agc aag gag atc cag  gag ctc        4768
Gln Met His  Ile Val Asp Met Leu  Ser Lys Glu Ile Gln  Glu Leu            
        1530                 1535                 1540                    

cag agc aaa  ccg gac cgc agc gcc  gag gag agc gac cgg  ctg cgc        4813
Gln Ser Lys  Pro Asp Arg Ser Ala  Glu Glu Ser Asp Arg  Leu Arg            
        1545                 1550                 1555                    

aag ctc atg  ctg gag tgg cag ttc  cag aag aga ctc cag  gag tcg        4858
Lys Leu Met  Leu Glu Trp Gln Phe  Gln Lys Arg Leu Gln  Glu Ser            
        1560                 1565                 1570                    

aag cag aag  gac gaa gat gac gag  gag gag gag gac gat  gat gtg        4903
Lys Gln Lys  Asp Glu Asp Asp Glu  Glu Glu Glu Asp Asp  Asp Val            
        1575                 1580                 1585                    

gac acc atg  ctg atc atg cag cgc  ctg gag gct gaa cga  aga gcg        4948
Asp Thr Met  Leu Ile Met Gln Arg  Leu Glu Ala Glu Arg  Arg Ala            
        1590                 1595                 1600                    

agg act gct  atg cca gca atc tct  gtt cta gat ttg ttg  cag gac        4993
Arg Thr Ala  Met Pro Ala Ile Ser  Val Leu Asp Leu Leu  Gln Asp            
        1605                 1610                 1615                    

gag gag cgg  agg cgg cag cag cag  tta gaa gag atg cgc  aag cgg        5038
Glu Glu Arg  Arg Arg Gln Gln Gln  Leu Glu Glu Met Arg  Lys Arg            
        1620                 1625                 1630                    

gaa gcg gaa  gac cga gcg agg caa  gag gaa gag cgc cgg  cgg cag        5083
Glu Ala Glu  Asp Arg Ala Arg Gln  Glu Glu Glu Arg Arg  Arg Gln            
        1635                 1640                 1645                    

gag gag gag  cga aca aaa cga gac  gct gaa gaa aag agg  cga cag        5128
Glu Glu Glu  Arg Thr Lys Arg Asp  Ala Glu Glu Lys Arg  Arg Gln            
        1650                 1655                 1660                    

gaa gaa ggg  tat tac agc cgc ctg  gaa gcc gag agg cgc  aga cag        5173
Glu Glu Gly  Tyr Tyr Ser Arg Leu  Glu Ala Glu Arg Arg  Arg Gln            
        1665                 1670                 1675                    

cac gac gag  gcg gcg cgc agg ttg  ctg gag ccc gag gcg  ccc ggt        5218
His Asp Glu  Ala Ala Arg Arg Leu  Leu Glu Pro Glu Ala  Pro Gly            
        1680                 1685                 1690                    

ctg tgc cgc  cct ccg ctt ccc cgg  gac tac gag ccc ccg  tcc ccg        5263
Leu Cys Arg  Pro Pro Leu Pro Arg  Asp Tyr Glu Pro Pro  Ser Pro            
        1695                 1700                 1705                    

tcc ccc gcg  ccc ggc gcc cct cct  ccc ccg cct cag cga  aac gcc        5308
Ser Pro Ala  Pro Gly Ala Pro Pro  Pro Pro Pro Gln Arg  Asn Ala            
        1710                 1715                 1720                    

tcc tac ctc  aaa aca cag gtc ctc  tcc ccc gac tcg ctg  ttc act        5353
Ser Tyr Leu  Lys Thr Gln Val Leu  Ser Pro Asp Ser Leu  Phe Thr            
        1725                 1730                 1735                    

gcc aag ttt  gtt gca tac aat gag  gag gag gag gag gag  gac tgc        5398
Ala Lys Phe  Val Ala Tyr Asn Glu  Glu Glu Glu Glu Glu  Asp Cys            
        1740                 1745                 1750                    

agc cta gca  gga cca aac tct tac  cca gga tct act gga  gca gct        5443
Ser Leu Ala  Gly Pro Asn Ser Tyr  Pro Gly Ser Thr Gly  Ala Ala            
        1755                 1760                 1765                    

gtt gga gcc  cat gac gcc tgt cgg  gat gca aaa gag aag  cgc tct        5488
Val Gly Ala  His Asp Ala Cys Arg  Asp Ala Lys Glu Lys  Arg Ser            
        1770                 1775                 1780                    

aaa agc caa  gat gca gat tca cct  gga agt tct ggg gcc  cct gaa        5533
Lys Ser Gln  Asp Ala Asp Ser Pro  Gly Ser Ser Gly Ala  Pro Glu            
        1785                 1790                 1795                    

aac ttg aca  ttc aag gaa cgc cag  cgt ctt ttt tca caa  ggt caa        5578
Asn Leu Thr  Phe Lys Glu Arg Gln  Arg Leu Phe Ser Gln  Gly Gln            
        1800                 1805                 1810                    

gat gta tcc  aat aaa gtg aaa gct  tct cgt aaa tta aca  gaa ctg        5623
Asp Val Ser  Asn Lys Val Lys Ala  Ser Arg Lys Leu Thr  Glu Leu            
        1815                 1820                 1825                    

gag aat gaa  ctg aac aca aag tga aagaaaatga ggagaacact ttgtatttac     5677
Glu Asn Glu  Leu Asn Thr Lys                                              
        1830                                                              

cccaaaatct tttcagttgt gggtttgtag gtgcgagttt gaagaggaaa agaggaaggg     5737

ggttatattt ctaagtgatt tacaatttct gtttctaaaa ttgttgggat ttagaaatgt     5797

ttcaattcca agaaatttta ttttacttta ccatgagatt gccatttatg taatttaaac     5857

actgtctagt ttcttaatta tctaactcac acgagggtaa gttttttgtt ggtttctttt     5917

ttggagtcct gagttcaaag gggacagaac taagggcagg agaagagaat ggatgtgtct     5977

tctctcccat cttcccctca tcatcgaccg aggagcacaa agaagttctg tttctgtttt     6037

tttcagaaac tttattttag ctgtcaagca gagaatagct tgaactattc agactattgt     6097

tggcactgtt tagtagtgac cacacgctct tctacccggg aaggaacata tgacgacatg     6157

ctcctcccat gtcccctgat ggtgtctgtt cccacaatat ccttctagtc tgcatcgtga     6217

agtggcttag gccaaagctt cctgtgtgat gacgcacgtc cgagactgtt ccatctcatt     6277

cctcgcaaat ttgagctctt ctgatcaatt ctaaatattt gattaatttt aattctgaaa     6337

gaaaattttg aggatttaag cttaggggat tttattttta taaataccag attattgtta     6397

gacttaataa atcactgtta aatttaaaga tgacagttac cttggaaagt tcactaatac     6457

ttcgctccaa ggcgtctgta aaagaagata tctttattgg agcaatgttc atgtgactgg     6517

gaatgacaga agaatgggag atgagtaggg acccctcaag cacagctgtc actcagaaat     6577

tttaaatttg aaaaagaaat cgattttcat ctgtatgccg tcaaggaagg aattcagtta     6637

cagggcatct gtaacttaaa tattgtaaga ataactcata tggaagttca agctattttt     6697

atactataat agagttattt aattttaatt tgttgaatta ttagttacca ctgtcatttc     6757

ttcagctatg gatatgtggc tgatgttggg gagacggacc tcagtgtgtt ttatattgtc     6817

tggtgttaag atgataaatt actttgtgat tacaagcaaa ttttctattt gacaaagccc     6877

ttggtggagt ccaaatgatt tttctgtacc atattgttct cttacacata cgtatgttag     6937

gaaaataggc acactttcaa agagaatgtt ctcttacaca tacgtatgtt aggaaaatag     6997

acacattttc aaagagaatg ttctcttaca tatgttagga aaataggcac actttcaaag     7057

agaggtatag gggcttttta ctgccttcga aatcactttt aataaaagtt gtatgataaa     7117

tcattaaaaa tgcgagtgta aatatttttt tttacctcta tcagggtttt tatttgaaag     7177

tgtgctctta ccatttcctt gtttgagtaa gagagtgaat ggttctgagt gtttaggaag     7237

gatttgcttg cttgcagcag aagttctagg aaaagcaggc acctcccaaa tatcttgagg     7297

acactggcag ccttatggtg actaaatcca cactttcttt aaagagatgc agatgaatta     7357

cttttctgtt aatatataga aaaatacaca ggagaacatg cagatacatg taaatatcta     7417

catacaggga tatttgtatg tgtggttgtg aaacccatac acaagtggat ttggccatct     7477

ttgggcagtg aggtcaaatg tgaatatgtg taaaagtgct tttcagaact gcattactat     7537

gagaaaacat caaaactgct gtagttttcc atttctactg tatttcagtt gcaacctatt     7597

tttaataaac tttgtatgta tttaagtgta tttgctattg ttttgaaagt gctgacaaag     7657

tttatatttg taacatcagc cttcctcgcc catctctttc catctgtctc ttcttcatta     7717

aacacttact gagtatgaaa aaaaaaaaaa aaaaaaaaaa aaaaa                     7762


<210>  404
<211>  1834
<212>  PRT
<213>  Homo sapiens

<400>  404

Met Ser Ala Gly Gly Arg Asp Glu Glu Arg Arg Lys Leu Ala Asp Ile 
1               5                   10                  15      


Ile His His Trp Asn Ala Asn Arg Leu Asp Leu Phe Glu Ile Ser Gln 
            20                  25                  30          


Pro Thr Glu Asp Leu Glu Phe His Gly Val Met Arg Phe Tyr Phe Gln 
        35                  40                  45              


Asp Lys Ala Ala Gly Asn Phe Ala Thr Lys Cys Ile Arg Val Ser Ser 
    50                  55                  60                  


Thr Ala Thr Thr Gln Asp Val Ile Glu Thr Leu Ala Glu Lys Phe Arg 
65                  70                  75                  80  


Pro Asp Met Arg Met Leu Ser Ser Pro Lys Tyr Ser Leu Tyr Glu Val 
                85                  90                  95      


His Val Ser Gly Glu Arg Arg Leu Asp Ile Asp Glu Lys Pro Leu Val 
            100                 105                 110         


Val Gln Leu Asn Trp Asn Lys Asp Asp Arg Glu Gly Arg Phe Val Leu 
        115                 120                 125             


Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys Ala Gln Ser Asn Gly Pro 
    130                 135                 140                 


Glu Lys Gln Glu Lys Glu Gly Val Ile Gln Asn Phe Lys Arg Thr Leu 
145                 150                 155                 160 


Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys Arg Glu Lys Glu Ala Leu 
                165                 170                 175     


Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro Phe Gln Gly Glu Asp Val 
            180                 185                 190         


Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr Lys Asp Met Pro Glu Thr 
        195                 200                 205             


Ser Phe Thr Arg Thr Ile Ser Asn Pro Glu Val Val Met Lys Arg Arg 
    210                 215                 220                 


Arg Gln Gln Lys Leu Glu Lys Arg Met Gln Glu Phe Arg Ser Ser Asp 
225                 230                 235                 240 


Gly Arg Pro Asp Ser Gly Gly Thr Leu Arg Ile Tyr Ala Asp Ser Leu 
                245                 250                 255     


Lys Pro Asn Ile Pro Tyr Lys Thr Ile Leu Leu Ser Thr Thr Asp Pro 
            260                 265                 270         


Ala Asp Phe Ala Val Ala Glu Ala Leu Glu Lys Tyr Gly Leu Glu Lys 
        275                 280                 285             


Glu Asn Pro Lys Asp Tyr Cys Ile Ala Arg Val Met Leu Pro Pro Gly 
    290                 295                 300                 


Ala Gln His Ser Asp Glu Lys Gly Ala Lys Glu Ile Ile Leu Asp Asp 
305                 310                 315                 320 


Asp Glu Cys Pro Leu Gln Ile Phe Arg Glu Trp Pro Ser Asp Lys Gly 
                325                 330                 335     


Ile Leu Val Phe Gln Leu Lys Arg Arg Pro Pro Asp His Ile Pro Lys 
            340                 345                 350         


Lys Thr Lys Lys His Leu Glu Gly Lys Thr Pro Lys Gly Lys Glu Arg 
        355                 360                 365             


Ala Asp Gly Ser Gly Tyr Gly Ser Thr Leu Pro Pro Glu Lys Leu Pro 
    370                 375                 380                 


Tyr Leu Val Glu Leu Ser Pro Gly Arg Arg Asn His Phe Ala Tyr Tyr 
385                 390                 395                 400 


Asn Tyr His Thr Tyr Glu Asp Gly Ser Asp Ser Arg Asp Lys Pro Lys 
                405                 410                 415     


Leu Tyr Arg Leu Gln Leu Ser Val Thr Glu Val Gly Thr Glu Lys Leu 
            420                 425                 430         


Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro Gly Ile Gln Pro His His 
        435                 440                 445             


Cys Asp Leu Thr Asn Met Asp Gly Val Val Thr Val Thr Pro Arg Ser 
    450                 455                 460                 


Met Asp Ala Glu Thr Tyr Val Glu Gly Gln Arg Ile Ser Glu Thr Thr 
465                 470                 475                 480 


Met Leu Gln Ser Gly Met Lys Val Gln Phe Gly Ala Ser His Val Phe 
                485                 490                 495     


Lys Phe Val Asp Pro Ser Gln Asp His Ala Leu Ala Lys Arg Ser Val 
            500                 505                 510         


Asp Gly Gly Leu Met Val Lys Gly Pro Arg His Lys Pro Gly Ile Val 
        515                 520                 525             


Gln Glu Thr Thr Phe Asp Leu Gly Gly Asp Ile His Ser Gly Thr Ala 
    530                 535                 540                 


Leu Pro Thr Ser Lys Ser Thr Thr Arg Leu Asp Ser Asp Arg Val Ser 
545                 550                 555                 560 


Ser Ala Ser Ser Thr Ala Glu Arg Gly Met Val Lys Pro Met Ile Arg 
                565                 570                 575     


Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln Glu Ser Arg Thr Gln Asp 
            580                 585                 590         


Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala Ser Ile Glu Phe Arg Glu 
        595                 600                 605             


Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile Ile Asn Tyr Thr Asn Ser 
    610                 615                 620                 


Ser Thr Val His Phe Lys Leu Ser Pro Thr Tyr Val Leu Tyr Met Ala 
625                 630                 635                 640 


Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg Pro Asp Ile Ser Pro Thr 
                645                 650                 655     


Glu Arg Thr His Lys Val Ile Ala Val Val Asn Lys Met Val Ser Met 
            660                 665                 670         


Met Glu Gly Val Ile Gln Lys Gln Lys Asn Ile Ala Gly Ala Leu Ala 
        675                 680                 685             


Phe Trp Met Ala Asn Ala Ser Glu Leu Leu Asn Phe Ile Lys Gln Asp 
    690                 695                 700                 


Arg Asp Leu Ser Arg Ile Thr Leu Asp Ala Gln Asp Val Leu Ala His 
705                 710                 715                 720 


Leu Val Gln Met Ala Phe Lys Tyr Leu Val His Cys Leu Gln Ser Glu 
                725                 730                 735     


Leu Asn Asn Tyr Met Pro Ala Phe Leu Asp Asp Pro Glu Glu Asn Ser 
            740                 745                 750         


Leu Gln Arg Pro Lys Ile Asp Asp Val Leu His Thr Leu Thr Gly Ala 
        755                 760                 765             


Met Ser Leu Leu Arg Arg Cys Arg Val Asn Ala Ala Leu Thr Ile Gln 
    770                 775                 780                 


Leu Phe Ser Gln Leu Phe His Phe Ile Asn Met Trp Leu Phe Asn Arg 
785                 790                 795                 800 


Leu Val Thr Asp Pro Asp Ser Gly Leu Cys Ser His Tyr Trp Gly Ala 
                805                 810                 815     


Ile Ile Arg Gln Gln Leu Gly His Ile Glu Ala Trp Ala Glu Lys Gln 
            820                 825                 830         


Gly Leu Glu Leu Ala Ala Asp Cys His Leu Ser Arg Ile Val Gln Ala 
        835                 840                 845             


Thr Thr Leu Leu Thr Met Asp Lys Tyr Ala Pro Asp Asp Ile Pro Asn 
    850                 855                 860                 


Ile Asn Ser Thr Cys Phe Lys Leu Asn Ser Leu Gln Leu Gln Ala Leu 
865                 870                 875                 880 


Leu Gln Asn Tyr His Cys Ala Pro Asp Glu Pro Phe Ile Pro Thr Asp 
                885                 890                 895     


Leu Ile Glu Asn Val Val Thr Val Ala Glu Asn Thr Ala Asp Glu Leu 
            900                 905                 910         


Ala Arg Ser Asp Gly Arg Glu Val Gln Leu Glu Glu Asp Pro Asp Leu 
        915                 920                 925             


Gln Leu Pro Phe Leu Leu Pro Glu Asp Gly Tyr Ser Cys Asp Val Val 
    930                 935                 940                 


Arg Asn Ile Pro Asn Gly Leu Gln Glu Phe Leu Asp Pro Leu Cys Gln 
945                 950                 955                 960 


Arg Gly Phe Cys Arg Leu Ile Pro His Thr Arg Ser Pro Gly Thr Trp 
                965                 970                 975     


Thr Ile Tyr Phe Glu Gly Ala Asp Tyr Glu Ser His Leu Leu Arg Glu 
            980                 985                 990         


Asn Thr Glu Leu Ala Gln Pro Leu  Arg Lys Glu Pro Glu  Ile Ile Thr 
        995                 1000                 1005             


Val Thr  Leu Lys Lys Gln Asn  Gly Met Gly Leu Ser  Ile Val Ala 
    1010                 1015                 1020             


Ala Lys  Gly Ala Gly Gln Asp  Lys Leu Gly Ile Tyr  Val Lys Ser 
    1025                 1030                 1035             


Val Val  Lys Gly Gly Ala Ala  Asp Val Asp Gly Arg  Leu Ala Ala 
    1040                 1045                 1050             


Gly Asp  Gln Leu Leu Ser Val  Asp Gly Arg Ser Leu  Val Gly Leu 
    1055                 1060                 1065             


Ser Gln  Glu Arg Ala Ala Glu  Leu Met Thr Arg Thr  Ser Ser Val 
    1070                 1075                 1080             


Val Thr  Leu Glu Val Ala Lys  Gln Gly Ala Ile Tyr  His Gly Leu 
    1085                 1090                 1095             


Ala Thr  Leu Leu Asn Gln Pro  Ser Pro Met Met Gln  Arg Ile Ser 
    1100                 1105                 1110             


Asp Arg  Arg Gly Ser Gly Lys  Pro Arg Pro Lys Ser  Glu Gly Phe 
    1115                 1120                 1125             


Glu Leu  Tyr Asn Asn Ser Thr  Gln Asn Gly Ser Pro  Glu Ser Pro 
    1130                 1135                 1140             


Gln Leu  Pro Trp Ala Glu Tyr  Ser Glu Pro Lys Lys  Leu Pro Gly 
    1145                 1150                 1155             


Asp Asp  Arg Leu Met Lys Asn  Arg Ala Asp His Arg  Ser Ser Pro 
    1160                 1165                 1170             


Asn Val  Ala Asn Gln Pro Pro  Ser Pro Gly Gly Lys  Ser Ala Tyr 
    1175                 1180                 1185             


Ala Ser  Gly Thr Thr Ala Lys  Ile Thr Ser Val Ser  Thr Gly Asn 
    1190                 1195                 1200             


Leu Cys  Thr Glu Glu Gln Thr  Pro Pro Pro Arg Pro  Glu Ala Tyr 
    1205                 1210                 1215             


Pro Ile  Pro Thr Gln Thr Tyr  Thr Arg Glu Tyr Phe  Thr Phe Pro 
    1220                 1225                 1230             


Ala Ser  Lys Ser Gln Asp Arg  Met Ala Pro Pro Gln  Asn Gln Trp 
    1235                 1240                 1245             


Pro Asn  Tyr Glu Glu Lys Pro  His Met His Thr Asp  Ser Asn His 
    1250                 1255                 1260             


Ser Ser  Ile Ala Ile Gln Arg  Val Thr Arg Ser Gln  Glu Glu Leu 
    1265                 1270                 1275             


Arg Glu  Asp Lys Ala Tyr Gln  Leu Glu Arg His Arg  Ile Glu Ala 
    1280                 1285                 1290             


Ala Met  Asp Arg Lys Ser Asp  Ser Asp Met Trp Ile  Asn Gln Ser 
    1295                 1300                 1305             


Ser Ser  Leu Asp Ser Ser Thr  Ser Ser Gln Glu His  Leu Asn His 
    1310                 1315                 1320             


Ser Ser  Lys Ser Val Thr Pro  Ala Ser Thr Leu Thr  Lys Ser Gly 
    1325                 1330                 1335             


Pro Gly  Arg Trp Lys Thr Pro  Ala Ala Ile Pro Ala  Thr Pro Val 
    1340                 1345                 1350             


Ala Val  Ser Gln Pro Ile Arg  Thr Asp Leu Pro Pro  Pro Pro Pro 
    1355                 1360                 1365             


Pro Pro  Pro Val His Tyr Ala  Gly Asp Phe Asp Gly  Met Ser Met 
    1370                 1375                 1380             


Asp Leu  Pro Leu Pro Pro Pro  Pro Ser Ala Asn Gln  Ile Gly Leu 
    1385                 1390                 1395             


Pro Ser  Ala Gln Val Ala Ala  Ala Glu Arg Arg Lys  Arg Glu Glu 
    1400                 1405                 1410             


His Gln  Arg Trp Tyr Glu Lys  Glu Lys Ala Arg Leu  Glu Glu Glu 
    1415                 1420                 1425             


Arg Glu  Arg Lys Arg Arg Glu  Gln Glu Arg Lys Leu  Gly Gln Met 
    1430                 1435                 1440             


Arg Thr  Gln Ser Leu Asn Pro  Ala Pro Phe Ser Pro  Leu Thr Ala 
    1445                 1450                 1455             


Gln Gln  Met Lys Pro Glu Lys  Pro Ser Thr Leu Gln  Arg Pro Gln 
    1460                 1465                 1470             


Glu Thr  Val Ile Arg Glu Leu  Gln Pro Gln Gln Gln  Pro Arg Thr 
    1475                 1480                 1485             


Ile Glu  Arg Arg Asp Leu Gln  Tyr Ile Thr Val Ser  Lys Glu Glu 
    1490                 1495                 1500             


Leu Ser  Ser Gly Asp Ser Leu  Ser Pro Asp Pro Trp  Lys Arg Asp 
    1505                 1510                 1515             


Ala Lys  Glu Lys Leu Glu Lys  Gln Gln Gln Met His  Ile Val Asp 
    1520                 1525                 1530             


Met Leu  Ser Lys Glu Ile Gln  Glu Leu Gln Ser Lys  Pro Asp Arg 
    1535                 1540                 1545             


Ser Ala  Glu Glu Ser Asp Arg  Leu Arg Lys Leu Met  Leu Glu Trp 
    1550                 1555                 1560             


Gln Phe  Gln Lys Arg Leu Gln  Glu Ser Lys Gln Lys  Asp Glu Asp 
    1565                 1570                 1575             


Asp Glu  Glu Glu Glu Asp Asp  Asp Val Asp Thr Met  Leu Ile Met 
    1580                 1585                 1590             


Gln Arg  Leu Glu Ala Glu Arg  Arg Ala Arg Thr Ala  Met Pro Ala 
    1595                 1600                 1605             


Ile Ser  Val Leu Asp Leu Leu  Gln Asp Glu Glu Arg  Arg Arg Gln 
    1610                 1615                 1620             


Gln Gln  Leu Glu Glu Met Arg  Lys Arg Glu Ala Glu  Asp Arg Ala 
    1625                 1630                 1635             


Arg Gln  Glu Glu Glu Arg Arg  Arg Gln Glu Glu Glu  Arg Thr Lys 
    1640                 1645                 1650             


Arg Asp  Ala Glu Glu Lys Arg  Arg Gln Glu Glu Gly  Tyr Tyr Ser 
    1655                 1660                 1665             


Arg Leu  Glu Ala Glu Arg Arg  Arg Gln His Asp Glu  Ala Ala Arg 
    1670                 1675                 1680             


Arg Leu  Leu Glu Pro Glu Ala  Pro Gly Leu Cys Arg  Pro Pro Leu 
    1685                 1690                 1695             


Pro Arg  Asp Tyr Glu Pro Pro  Ser Pro Ser Pro Ala  Pro Gly Ala 
    1700                 1705                 1710             


Pro Pro  Pro Pro Pro Gln Arg  Asn Ala Ser Tyr Leu  Lys Thr Gln 
    1715                 1720                 1725             


Val Leu  Ser Pro Asp Ser Leu  Phe Thr Ala Lys Phe  Val Ala Tyr 
    1730                 1735                 1740             


Asn Glu  Glu Glu Glu Glu Glu  Asp Cys Ser Leu Ala  Gly Pro Asn 
    1745                 1750                 1755             


Ser Tyr  Pro Gly Ser Thr Gly  Ala Ala Val Gly Ala  His Asp Ala 
    1760                 1765                 1770             


Cys Arg  Asp Ala Lys Glu Lys  Arg Ser Lys Ser Gln  Asp Ala Asp 
    1775                 1780                 1785             


Ser Pro  Gly Ser Ser Gly Ala  Pro Glu Asn Leu Thr  Phe Lys Glu 
    1790                 1795                 1800             


Arg Gln  Arg Leu Phe Ser Gln  Gly Gln Asp Val Ser  Asn Lys Val 
    1805                 1810                 1815             


Lys Ala  Ser Arg Lys Leu Thr  Glu Leu Glu Asn Glu  Leu Asn Thr 
    1820                 1825                 1830             


Lys 
    


<210>  405
<211>  2538
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (109)..(1149)

<400>  405
atgcgcagaa gcactccggg cgtgctgccg gcggcggtag gtggcgcgcg ggtccggcgg       60

gcggttggct tgagcgggac cggagctgag gcaggaagag ccggcgcc atg gtg gag       117
                                                     Met Val Glu          
                                                     1                    

aag gag gag gct ggc ggc ggc att agc gag gag gag gcg gca cag tat        165
Lys Glu Glu Ala Gly Gly Gly Ile Ser Glu Glu Glu Ala Ala Gln Tyr           
    5                   10                  15                            

gac cgg cag atc cgc ctg tgg gga ctg gag gcc cag aaa cgg ctg cgg        213
Asp Arg Gln Ile Arg Leu Trp Gly Leu Glu Ala Gln Lys Arg Leu Arg           
20                  25                  30                  35            

gcc tct cgg gtg ctt ctt gtc ggc ttg aaa gga ctt ggg gct gaa att        261
Ala Ser Arg Val Leu Leu Val Gly Leu Lys Gly Leu Gly Ala Glu Ile           
                40                  45                  50                

gcc aag aat ctc atc ttg gca gga gtg aaa gga ctg acc atg ctg gat        309
Ala Lys Asn Leu Ile Leu Ala Gly Val Lys Gly Leu Thr Met Leu Asp           
            55                  60                  65                    

cac gaa cag gta act cca gaa gat ccc gga gct cag ttc ttg att cgt        357
His Glu Gln Val Thr Pro Glu Asp Pro Gly Ala Gln Phe Leu Ile Arg           
        70                  75                  80                        

act ggg tct gtt ggc cga aat agg gct gaa gcc tct ttg gag cga gct        405
Thr Gly Ser Val Gly Arg Asn Arg Ala Glu Ala Ser Leu Glu Arg Ala           
    85                  90                  95                            

cag aat ctc aac ccc atg gtg gat gtg aag gtg gac act gag gat ata        453
Gln Asn Leu Asn Pro Met Val Asp Val Lys Val Asp Thr Glu Asp Ile           
100                 105                 110                 115           

gag aag aaa cca gag tca ttt ttc act caa ttc gat gct gtg tgt ctg        501
Glu Lys Lys Pro Glu Ser Phe Phe Thr Gln Phe Asp Ala Val Cys Leu           
                120                 125                 130               

act tgc tgc tcc agg gat gtc ata gtt aaa gtt gac cag atc tgt cac        549
Thr Cys Cys Ser Arg Asp Val Ile Val Lys Val Asp Gln Ile Cys His           
            135                 140                 145                   

aaa aat agc atc aag ttc ttt aca gga gat gtt ttt ggc tac cat gga        597
Lys Asn Ser Ile Lys Phe Phe Thr Gly Asp Val Phe Gly Tyr His Gly           
        150                 155                 160                       

tac aca ttt gcc aat cta gga gag cat gag ttt gta gag gag aaa act        645
Tyr Thr Phe Ala Asn Leu Gly Glu His Glu Phe Val Glu Glu Lys Thr           
    165                 170                 175                           

aaa gtt gcc aaa gtt agc caa gga gta gaa gat ggg ccc gac acc aag        693
Lys Val Ala Lys Val Ser Gln Gly Val Glu Asp Gly Pro Asp Thr Lys           
180                 185                 190                 195           

aga gca aaa ctt gat tct tct gag aca acg atg gtc aaa aag aag gtg        741
Arg Ala Lys Leu Asp Ser Ser Glu Thr Thr Met Val Lys Lys Lys Val           
                200                 205                 210               

gtc ttc tgc cct gtt aaa gaa gcc ctg gag gtg gac tgg agc agt gag        789
Val Phe Cys Pro Val Lys Glu Ala Leu Glu Val Asp Trp Ser Ser Glu           
            215                 220                 225                   

aaa gca aag gct gct ctg aag cgc acg acc tcc gac tac ttt ctc ctt        837
Lys Ala Lys Ala Ala Leu Lys Arg Thr Thr Ser Asp Tyr Phe Leu Leu           
        230                 235                 240                       

caa gtg ctc tta aag ttc cgt aca gat aaa gga aga gat ccc agt tct        885
Gln Val Leu Leu Lys Phe Arg Thr Asp Lys Gly Arg Asp Pro Ser Ser           
    245                 250                 255                           

gat aca tat gag gaa gat tct gag ttg ttg ctc cag ata cga aat gat        933
Asp Thr Tyr Glu Glu Asp Ser Glu Leu Leu Leu Gln Ile Arg Asn Asp           
260                 265                 270                 275           

gtg ctt gac tca ctg ggt att agt cct gac ctg ctt cct gag gac ttt        981
Val Leu Asp Ser Leu Gly Ile Ser Pro Asp Leu Leu Pro Glu Asp Phe           
                280                 285                 290               

gtc agg tac tgc ttc tcc gag atg gcc cca gtg tgt gcg gtg gtt gga       1029
Val Arg Tyr Cys Phe Ser Glu Met Ala Pro Val Cys Ala Val Val Gly           
            295                 300                 305                   

ggg att ttg gca cag gaa att gtg aag gcc ctg tct cag cgg gac cct       1077
Gly Ile Leu Ala Gln Glu Ile Val Lys Ala Leu Ser Gln Arg Asp Pro           
        310                 315                 320                       

cct cac aac aac ttc ttc ttc ttc gat ggc atg aag ggg aat ggg att       1125
Pro His Asn Asn Phe Phe Phe Phe Asp Gly Met Lys Gly Asn Gly Ile           
    325                 330                 335                           

gtg gag tgc ctt ggc ccc aag tga actcaagatt tggcagcccc agagatgcca      1179
Val Glu Cys Leu Gly Pro Lys                                               
340                 345                                                   

actgcagcat gcccacctgt attccctgtc cccttccttc atgaaggcat ctccaggcaa     1239

ggaaaactga agtcattggc ccgatacaaa acatttcctg caacgaagga ggtggtgccg     1299

acgtgctgct tcccatcacc agcagctgct cgacaagggg cgcagggtgg ctgtctttgt     1359

tccagcactg ttcaggctgc ctgtcatccc gggcctgcca gctcccctga gtgatgagca     1419

cttccaagca cccctctgcc ctttctctgt ccttatgctg tcccggcctc gccagccctc     1479

tggggcattg tgggagatgc ctgccaggaa tgagcaagct ctgttgctcg ggagcctctt     1539

gtcaccttct tggacttatt ccccacctga taccttatag agaaaagtgt gaattcaggt     1599

ggagagtagg cccaggcccc atgaggcacc agtggaagca cagctccaag ttcagacagg     1659

tgcccttaga gaggaaaacc atgacaggca aatgcatttc ctctggagtt tgagaccctg     1719

acaaacaaca ggtggcatct ggtgtgctgt tcttgagttt tcgtttagga ttagttgagt     1779

tccagctggg ttttgggaga aaggagatgc taccaagtct tggatgttag ggcgagaccc     1839

tgcaagttga gtattagaga gcttgtcttt caaggcaggt tcctggggct tcagggctag     1899

gagggaggag cctgcccttt taacagaacc ccagtcacat gcggctcaag tcactcagag     1959

gctgttgcat ttcagggcta tgttggtcct ttgtttacct cctaaaccac agctgtttgt     2019

gtttcacata tgttgtgaat tttccttggt tctttttaaa ggaatgataa taaagttact     2079

tgctttagga tttgcttgtt tttcttccac ttcagaagct tctgagaggg aatgggatga     2139

tcctaccagt tgccttttca gacctgaggc tctaactcaa gagattcctc ctctccctca     2199

ccattcctgc caccattttt tctgggtgat gcagcaagag ttaaattgtt cacattctag     2259

aatgtgtaga agcttctggc tccagttgtc taatggataa ttcagctaaa tagtggctat     2319

tttcagtggc aagaattata ataataaagg gaagtcaaaa gtgatgcttc atatgcccca     2379

agtgccacag ccgctacggg tcagagcttt tattggaaga ccaggtttgc cttgatgcag     2439

ccaaagtgcg ttccagttca ccccactctt gcttgtgttt cttctttatg taaattgtgt     2499

gatgtttcaa taaatcagtc tctttcctat tctgaaaaa                            2538


<210>  406
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  406

Met Val Glu Lys Glu Glu Ala Gly Gly Gly Ile Ser Glu Glu Glu Ala 
1               5                   10                  15      


Ala Gln Tyr Asp Arg Gln Ile Arg Leu Trp Gly Leu Glu Ala Gln Lys 
            20                  25                  30          


Arg Leu Arg Ala Ser Arg Val Leu Leu Val Gly Leu Lys Gly Leu Gly 
        35                  40                  45              


Ala Glu Ile Ala Lys Asn Leu Ile Leu Ala Gly Val Lys Gly Leu Thr 
    50                  55                  60                  


Met Leu Asp His Glu Gln Val Thr Pro Glu Asp Pro Gly Ala Gln Phe 
65                  70                  75                  80  


Leu Ile Arg Thr Gly Ser Val Gly Arg Asn Arg Ala Glu Ala Ser Leu 
                85                  90                  95      


Glu Arg Ala Gln Asn Leu Asn Pro Met Val Asp Val Lys Val Asp Thr 
            100                 105                 110         


Glu Asp Ile Glu Lys Lys Pro Glu Ser Phe Phe Thr Gln Phe Asp Ala 
        115                 120                 125             


Val Cys Leu Thr Cys Cys Ser Arg Asp Val Ile Val Lys Val Asp Gln 
    130                 135                 140                 


Ile Cys His Lys Asn Ser Ile Lys Phe Phe Thr Gly Asp Val Phe Gly 
145                 150                 155                 160 


Tyr His Gly Tyr Thr Phe Ala Asn Leu Gly Glu His Glu Phe Val Glu 
                165                 170                 175     


Glu Lys Thr Lys Val Ala Lys Val Ser Gln Gly Val Glu Asp Gly Pro 
            180                 185                 190         


Asp Thr Lys Arg Ala Lys Leu Asp Ser Ser Glu Thr Thr Met Val Lys 
        195                 200                 205             


Lys Lys Val Val Phe Cys Pro Val Lys Glu Ala Leu Glu Val Asp Trp 
    210                 215                 220                 


Ser Ser Glu Lys Ala Lys Ala Ala Leu Lys Arg Thr Thr Ser Asp Tyr 
225                 230                 235                 240 


Phe Leu Leu Gln Val Leu Leu Lys Phe Arg Thr Asp Lys Gly Arg Asp 
                245                 250                 255     


Pro Ser Ser Asp Thr Tyr Glu Glu Asp Ser Glu Leu Leu Leu Gln Ile 
            260                 265                 270         


Arg Asn Asp Val Leu Asp Ser Leu Gly Ile Ser Pro Asp Leu Leu Pro 
        275                 280                 285             


Glu Asp Phe Val Arg Tyr Cys Phe Ser Glu Met Ala Pro Val Cys Ala 
    290                 295                 300                 


Val Val Gly Gly Ile Leu Ala Gln Glu Ile Val Lys Ala Leu Ser Gln 
305                 310                 315                 320 


Arg Asp Pro Pro His Asn Asn Phe Phe Phe Phe Asp Gly Met Lys Gly 
                325                 330                 335     


Asn Gly Ile Val Glu Cys Leu Gly Pro Lys 
            340                 345     


<210>  407
<211>  1880
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (53)..(811)

<400>  407
agccgagagg tgtcaccccc agcgggcgcg ggccggagca cgggcaccca gc atg ggg       58
                                                          Met Gly         
                                                          1               

gta ctg ctc aca cag agg acg ctg ctc agt ctg gtc ctt gca ctc ctg        106
Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala Leu Leu           
        5                   10                  15                        

ttt cca agc atg gcg agc atg gcg gct ata ggc agc tgc tcg aaa gag        154
Phe Pro Ser Met Ala Ser Met Ala Ala Ile Gly Ser Cys Ser Lys Glu           
    20                  25                  30                            

tac cgc gtg ctc ctt ggc cag ctc cag aag cag aca gat ctc atg cag        202
Tyr Arg Val Leu Leu Gly Gln Leu Gln Lys Gln Thr Asp Leu Met Gln           
35                  40                  45                  50            

gac acc agc aga ctc ctg gac ccc tat ata cgt atc caa ggc ctg gat        250
Asp Thr Ser Arg Leu Leu Asp Pro Tyr Ile Arg Ile Gln Gly Leu Asp           
                55                  60                  65                

gtt cct aaa ctg aga gag cac tgc agg gag cgc ccc ggg gcc ttc ccc        298
Val Pro Lys Leu Arg Glu His Cys Arg Glu Arg Pro Gly Ala Phe Pro           
            70                  75                  80                    

agt gag gag acc ctg agg ggg ctg ggc agg cgg ggc ttc ctg cag acc        346
Ser Glu Glu Thr Leu Arg Gly Leu Gly Arg Arg Gly Phe Leu Gln Thr           
        85                  90                  95                        

ctc aat gcc aca ctg ggc tgc gtc ctg cac aga ctg gcc gac tta gag        394
Leu Asn Ala Thr Leu Gly Cys Val Leu His Arg Leu Ala Asp Leu Glu           
    100                 105                 110                           

cag cgc ctc ccc aag gcc cag gat ttg gag agg tct ggg ctg aac atc        442
Gln Arg Leu Pro Lys Ala Gln Asp Leu Glu Arg Ser Gly Leu Asn Ile           
115                 120                 125                 130           

gag gac ttg gag aag ctg cag atg gcg agg ccg aac atc ctc ggg ctc        490
Glu Asp Leu Glu Lys Leu Gln Met Ala Arg Pro Asn Ile Leu Gly Leu           
                135                 140                 145               

agg aac aac atc tac tgc atg gcc cag ctg ctg gac aac tca gac acg        538
Arg Asn Asn Ile Tyr Cys Met Ala Gln Leu Leu Asp Asn Ser Asp Thr           
            150                 155                 160                   

gct gag ccc acg aag gct ggc cgg ggg gcc tct cag ccg ccc acc ccc        586
Ala Glu Pro Thr Lys Ala Gly Arg Gly Ala Ser Gln Pro Pro Thr Pro           
        165                 170                 175                       

acc cct gcc tcg gat gct ttt cag cgc aag ctg gag ggc tgc agg ttc        634
Thr Pro Ala Ser Asp Ala Phe Gln Arg Lys Leu Glu Gly Cys Arg Phe           
    180                 185                 190                           

ctg cat ggc tac cat cgc ttc atg cac tca gtg ggg cgg gtc ttc agc        682
Leu His Gly Tyr His Arg Phe Met His Ser Val Gly Arg Val Phe Ser           
195                 200                 205                 210           

aag tgg ggg gag agc ccg aac cgg agc cgg aga cac agc ccc cac cag        730
Lys Trp Gly Glu Ser Pro Asn Arg Ser Arg Arg His Ser Pro His Gln           
                215                 220                 225               

gcc ctg agg aag ggg gtg cgc agg acc aga ccc tcc agg aaa ggc aag        778
Ala Leu Arg Lys Gly Val Arg Arg Thr Arg Pro Ser Arg Lys Gly Lys           
            230                 235                 240                   

aga ctc atg acc agg gga cag ctg ccc cgg tag cctcgagagc accccttgcc      831
Arg Leu Met Thr Arg Gly Gln Leu Pro Arg                                   
        245                 250                                           

ggtgaaggat gcggcaggtg ctctgtggat gagaggaacc atcgcaggat gacagctccc      891

gggtccccaa acctgttccc ctctgctact agccactgag aagtgcactt taagaggtgg      951

gagctgggca gacccctcta cctcctccag gctgggagac agagtcaggc tgttgcgctc     1011

ccacctcagc cccaagttcc ccaggcccag tggggtggcc gggcgggcca cgcgggaccg     1071

actttccatt gattcagggg tctgatgaca caggctgact catggccggg ctgactgccc     1131

ccctgccttg ctccccgagg cctgccggtc cttccctctc atgacttgca gggccgttgc     1191

ccccagactt cctcctttcc gtgtttctga aggggaggtc acagcctgag ctggcctcct     1251

atgcctcatc atgtcccaaa ccagacacct ggatgtctgg gtgacctcac tttaggcagc     1311

tgtaacagcg gcagggtgtc ccaggagccc tgatccgggg gtccagggaa tggagctcag     1371

gtcccaggcc agccccgaag tcgccacgtg gcctggggca ggtcacttta cctctgtgga     1431

cctgttttct ctttgtgaag ctagggagtt agaggctgta caaggccccc actgcctgtc     1491

ggttgcttgg attccctgac gtaaggtgga tattaaaaat ctgtaaatca ggacaggtgg     1551

tgcaaatggc gctgggaggt gtacacggag gtctctgtaa aagcagaccc acctcccagc     1611

gccgggaagc ccgtcttggg tcctcgctgc tggctgctcc ccctggtggt ggatcctgga     1671

attttctcac gcaggagcca ttgctctcct agagggggtc tcagaaactg cgaggccagt     1731

tccttggagg gacatgacta atttatcgat ttttatcaat ttttatcagt tttatattta     1791

taagccttat ttatgatgta tatttaatgt taatattgtg caaacttata tttaaaactt     1851

gcctggtttc taaaaaaaaa aaaaaaaaa                                       1880


<210>  408
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  408

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Ala Ile Gly Ser Cys Ser 
            20                  25                  30          


Lys Glu Tyr Arg Val Leu Leu Gly Gln Leu Gln Lys Gln Thr Asp Leu 
        35                  40                  45              


Met Gln Asp Thr Ser Arg Leu Leu Asp Pro Tyr Ile Arg Ile Gln Gly 
    50                  55                  60                  


Leu Asp Val Pro Lys Leu Arg Glu His Cys Arg Glu Arg Pro Gly Ala 
65                  70                  75                  80  


Phe Pro Ser Glu Glu Thr Leu Arg Gly Leu Gly Arg Arg Gly Phe Leu 
                85                  90                  95      


Gln Thr Leu Asn Ala Thr Leu Gly Cys Val Leu His Arg Leu Ala Asp 
            100                 105                 110         


Leu Glu Gln Arg Leu Pro Lys Ala Gln Asp Leu Glu Arg Ser Gly Leu 
        115                 120                 125             


Asn Ile Glu Asp Leu Glu Lys Leu Gln Met Ala Arg Pro Asn Ile Leu 
    130                 135                 140                 


Gly Leu Arg Asn Asn Ile Tyr Cys Met Ala Gln Leu Leu Asp Asn Ser 
145                 150                 155                 160 


Asp Thr Ala Glu Pro Thr Lys Ala Gly Arg Gly Ala Ser Gln Pro Pro 
                165                 170                 175     


Thr Pro Thr Pro Ala Ser Asp Ala Phe Gln Arg Lys Leu Glu Gly Cys 
            180                 185                 190         


Arg Phe Leu His Gly Tyr His Arg Phe Met His Ser Val Gly Arg Val 
        195                 200                 205             


Phe Ser Lys Trp Gly Glu Ser Pro Asn Arg Ser Arg Arg His Ser Pro 
    210                 215                 220                 


His Gln Ala Leu Arg Lys Gly Val Arg Arg Thr Arg Pro Ser Arg Lys 
225                 230                 235                 240 


Gly Lys Arg Leu Met Thr Arg Gly Gln Leu Pro Arg 
                245                 250         


<210>  409
<211>  4576
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (266)..(4231)

<400>  409
cggcagagga ggaggaggag gcggtgctcg cgccgggcgg tagagcggcg ctgggaccca       60

tgcggccgtg acccccggct ccctagaggc ccagcgcagc cgcagcggac aaaggagcat      120

gtccgcgccg gggaaggccc gtcctccggc cgccataagg ctccggtcgc cgctgggccc      180

gcgccgcgct cctgcccgcc cgggctccgg ggcggcccgc taggccagtg cgccgccgct      240

cgccccgcag gccccggccc gcagc atg gag cca ccc gga cgc cgg cgg ggc        292
                            Met Glu Pro Pro Gly Arg Arg Arg Gly           
                            1               5                             

cgc gcg cag ccg ccg ctg ttg ctg ccg ctc tcg ctg tta gcg ctg ctc        340
Arg Ala Gln Pro Pro Leu Leu Leu Pro Leu Ser Leu Leu Ala Leu Leu           
10                  15                  20                  25            

gcg ctg ctg gga ggc ggc ggc ggc ggc ggc gcc gcg gcg ctg ccc gcc        388
Ala Leu Leu Gly Gly Gly Gly Gly Gly Gly Ala Ala Ala Leu Pro Ala           
                30                  35                  40                

ggc tgc aag cac gat ggg cgg ccc cga ggg gct ggc agg gcg gcg ggc        436
Gly Cys Lys His Asp Gly Arg Pro Arg Gly Ala Gly Arg Ala Ala Gly           
            45                  50                  55                    

gcc gcc gag ggc aag gtg gtg tgc agc agc ctg gaa ctc gcg cag gtc        484
Ala Ala Glu Gly Lys Val Val Cys Ser Ser Leu Glu Leu Ala Gln Val           
        60                  65                  70                        

ctg ccc cca gat act ctg ccc aac cgc acg gtc acc ctg att ctg agt        532
Leu Pro Pro Asp Thr Leu Pro Asn Arg Thr Val Thr Leu Ile Leu Ser           
    75                  80                  85                            

aac aat aag ata tcc gag ctg aag aat ggc tca ttt tct ggg tta agt        580
Asn Asn Lys Ile Ser Glu Leu Lys Asn Gly Ser Phe Ser Gly Leu Ser           
90                  95                  100                 105           

ctc ctt gaa aga ttg gac ctc cga aac aat ctt att agt agt ata gat        628
Leu Leu Glu Arg Leu Asp Leu Arg Asn Asn Leu Ile Ser Ser Ile Asp           
                110                 115                 120               

cca ggt gcc ttc tgg gga ctg tca tct cta aaa aga ttg gat ctg aca        676
Pro Gly Ala Phe Trp Gly Leu Ser Ser Leu Lys Arg Leu Asp Leu Thr           
            125                 130                 135                   

aac aat cga ata gga tgt ctg aat gca gac ata ttt cga gga ctc acc        724
Asn Asn Arg Ile Gly Cys Leu Asn Ala Asp Ile Phe Arg Gly Leu Thr           
        140                 145                 150                       

aat ctg gtt cgg cta aac ctt tcg ggg aat ttg ttt tct tca tta tct        772
Asn Leu Val Arg Leu Asn Leu Ser Gly Asn Leu Phe Ser Ser Leu Ser           
    155                 160                 165                           

caa gga act ttt gat tat ctt gcg tca tta cgg tct ttg gaa ttc cag        820
Gln Gly Thr Phe Asp Tyr Leu Ala Ser Leu Arg Ser Leu Glu Phe Gln           
170                 175                 180                 185           

act gag tat ctt ttg tgt gac tgt aac ata ctg tgg atg cat cgc tgg        868
Thr Glu Tyr Leu Leu Cys Asp Cys Asn Ile Leu Trp Met His Arg Trp           
                190                 195                 200               

gta aag gag aag aac atc acg gta cgg gat acc agg tgt gtt tat cct        916
Val Lys Glu Lys Asn Ile Thr Val Arg Asp Thr Arg Cys Val Tyr Pro           
            205                 210                 215                   

aag tca ctg cag gcc caa cca gtc aca ggc gtg aag cag gag ctg ttg        964
Lys Ser Leu Gln Ala Gln Pro Val Thr Gly Val Lys Gln Glu Leu Leu           
        220                 225                 230                       

aca tgc gac cct ccg ctt gaa ttg ccg tct ttc tac atg act cca tct       1012
Thr Cys Asp Pro Pro Leu Glu Leu Pro Ser Phe Tyr Met Thr Pro Ser           
    235                 240                 245                           

cat cgc caa gtt gtg ttt gaa gga gac agc ctt cct ttc cag tgc atg       1060
His Arg Gln Val Val Phe Glu Gly Asp Ser Leu Pro Phe Gln Cys Met           
250                 255                 260                 265           

gct tca tat att gat cag gac atg caa gtg ttg tgg tat cag gat ggg       1108
Ala Ser Tyr Ile Asp Gln Asp Met Gln Val Leu Trp Tyr Gln Asp Gly           
                270                 275                 280               

aga ata gtt gaa acc gat gaa tcg caa ggt att ttt gtt gaa aag aac       1156
Arg Ile Val Glu Thr Asp Glu Ser Gln Gly Ile Phe Val Glu Lys Asn           
            285                 290                 295                   

atg att cac aac tgc tcc ttg att gca agt gcc cta acc att tct aat       1204
Met Ile His Asn Cys Ser Leu Ile Ala Ser Ala Leu Thr Ile Ser Asn           
        300                 305                 310                       

att cag gct gga tct act gga aat tgg ggc tgt cat gtc cag acc aaa       1252
Ile Gln Ala Gly Ser Thr Gly Asn Trp Gly Cys His Val Gln Thr Lys           
    315                 320                 325                           

cgt ggg aat aat acg agg act gtg gat att gtg gta tta gag agt tct       1300
Arg Gly Asn Asn Thr Arg Thr Val Asp Ile Val Val Leu Glu Ser Ser           
330                 335                 340                 345           

gca cag tac tgt cct cca gag agg gtg gta aac aac aaa ggt gac ttc       1348
Ala Gln Tyr Cys Pro Pro Glu Arg Val Val Asn Asn Lys Gly Asp Phe           
                350                 355                 360               

aga tgg ccc aga aca ttg gca ggc att act gca tat ctg cag tgt acg       1396
Arg Trp Pro Arg Thr Leu Ala Gly Ile Thr Ala Tyr Leu Gln Cys Thr           
            365                 370                 375                   

cgg aac acc cat ggc agt ggg ata tat ccc gga aac cca cag gat gag       1444
Arg Asn Thr His Gly Ser Gly Ile Tyr Pro Gly Asn Pro Gln Asp Glu           
        380                 385                 390                       

aga aaa gct tgg cgc aga tgt gat aga ggt ggc ttt tgg gca gat gat       1492
Arg Lys Ala Trp Arg Arg Cys Asp Arg Gly Gly Phe Trp Ala Asp Asp           
    395                 400                 405                           

gat tat tct cgc tgt cag tat gca aat gat gtc act aga gtt ctt tat       1540
Asp Tyr Ser Arg Cys Gln Tyr Ala Asn Asp Val Thr Arg Val Leu Tyr           
410                 415                 420                 425           

atg ttt aat cag atg ccc ctc aat ctt acc aat gcc gtg gca aca gct       1588
Met Phe Asn Gln Met Pro Leu Asn Leu Thr Asn Ala Val Ala Thr Ala           
                430                 435                 440               

cga cag tta ctg gct tac act gtg gaa gca gcc aac ttt tct gac aaa       1636
Arg Gln Leu Leu Ala Tyr Thr Val Glu Ala Ala Asn Phe Ser Asp Lys           
            445                 450                 455                   

atg gat gtt ata ttt gtg gca gaa atg att gaa aaa ttt gga aga ttt       1684
Met Asp Val Ile Phe Val Ala Glu Met Ile Glu Lys Phe Gly Arg Phe           
        460                 465                 470                       

acc aag gag gaa aaa tca aaa gag cta ggt gac gtg atg gtt gac att       1732
Thr Lys Glu Glu Lys Ser Lys Glu Leu Gly Asp Val Met Val Asp Ile           
    475                 480                 485                           

gca agt aac atc atg ttg gct gat gaa cgt gtc ctg tgg ctg gcg cag       1780
Ala Ser Asn Ile Met Leu Ala Asp Glu Arg Val Leu Trp Leu Ala Gln           
490                 495                 500                 505           

agg gaa gct aaa gcc tgc agt agg att gtg cag tgt ctt cag cgc att       1828
Arg Glu Ala Lys Ala Cys Ser Arg Ile Val Gln Cys Leu Gln Arg Ile           
                510                 515                 520               

gct acc tac cgg cta gcc ggt gga gct cac gtt tat tca aca tat tca       1876
Ala Thr Tyr Arg Leu Ala Gly Gly Ala His Val Tyr Ser Thr Tyr Ser           
            525                 530                 535                   

ccc aat att gct ctg gaa gct tat gtc atc aag tct act ggc ttc acg       1924
Pro Asn Ile Ala Leu Glu Ala Tyr Val Ile Lys Ser Thr Gly Phe Thr           
        540                 545                 550                       

ggg atg acc tgt acc gtg ttc cag aaa gtg gca gcc tct gat cgt aca       1972
Gly Met Thr Cys Thr Val Phe Gln Lys Val Ala Ala Ser Asp Arg Thr           
    555                 560                 565                           

gga ctt tcg gat tat ggg agg cgg gat cca gag gga aac ctg gat aag       2020
Gly Leu Ser Asp Tyr Gly Arg Arg Asp Pro Glu Gly Asn Leu Asp Lys           
570                 575                 580                 585           

cag ctg agc ttt aag tgc aat gtt tca aat aca ttt tcg agt ctg gca       2068
Gln Leu Ser Phe Lys Cys Asn Val Ser Asn Thr Phe Ser Ser Leu Ala           
                590                 595                 600               

cta aag aat act att gtg gag gct tct att cag ctt cct cct tcc ctt       2116
Leu Lys Asn Thr Ile Val Glu Ala Ser Ile Gln Leu Pro Pro Ser Leu           
            605                 610                 615                   

ttc tca cca aag caa aaa aga gaa ctc aga cca act gat gac tct ctt       2164
Phe Ser Pro Lys Gln Lys Arg Glu Leu Arg Pro Thr Asp Asp Ser Leu           
        620                 625                 630                       

tac aag ctt caa ctc att gca ttc cgc aat gga aag ctt ttt cca gcc       2212
Tyr Lys Leu Gln Leu Ile Ala Phe Arg Asn Gly Lys Leu Phe Pro Ala           
    635                 640                 645                           

act gga aat tca aca aat ttg gct gat gat gga aaa cga cgt act gtg       2260
Thr Gly Asn Ser Thr Asn Leu Ala Asp Asp Gly Lys Arg Arg Thr Val           
650                 655                 660                 665           

gtt acc cct gtg att ctc acc aaa ata gat ggt gtg aat gta gat acc       2308
Val Thr Pro Val Ile Leu Thr Lys Ile Asp Gly Val Asn Val Asp Thr           
                670                 675                 680               

cac cac atc cct gtt aat gtg aca ctg cgt cga att gca cat gga gca       2356
His His Ile Pro Val Asn Val Thr Leu Arg Arg Ile Ala His Gly Ala           
            685                 690                 695                   

gat gct gtt gca gcc cgg tgg gat ttc gat ttg ctg aac gga caa gga       2404
Asp Ala Val Ala Ala Arg Trp Asp Phe Asp Leu Leu Asn Gly Gln Gly           
        700                 705                 710                       

ggc tgg aag tca gat ggg tgc cat ata ctc tat tca gat gaa aat atc       2452
Gly Trp Lys Ser Asp Gly Cys His Ile Leu Tyr Ser Asp Glu Asn Ile           
    715                 720                 725                           

act acg att cag tgc tac tcc ctt agt aac tat gca gtt tta atg gat       2500
Thr Thr Ile Gln Cys Tyr Ser Leu Ser Asn Tyr Ala Val Leu Met Asp           
730                 735                 740                 745           

ttg acg gga tct gaa cta tac acc cag gcg gcc agc ctc ctg cat cct       2548
Leu Thr Gly Ser Glu Leu Tyr Thr Gln Ala Ala Ser Leu Leu His Pro           
                750                 755                 760               

gtg gtt tat act acc gct atc att ctc ctc tta tgt ctc tta gcc gtc       2596
Val Val Tyr Thr Thr Ala Ile Ile Leu Leu Leu Cys Leu Leu Ala Val           
            765                 770                 775                   

att gtc agt tac ata tac cat cac agt ttg att aga atc agc ctc aag       2644
Ile Val Ser Tyr Ile Tyr His His Ser Leu Ile Arg Ile Ser Leu Lys           
        780                 785                 790                       

agc tgg cac atg ctt gtg aac ttg tgc ttt cat att ttc cta acc tgt       2692
Ser Trp His Met Leu Val Asn Leu Cys Phe His Ile Phe Leu Thr Cys           
    795                 800                 805                           

gtg gtc ttt gtg gga gga ata acc cag act agg aat gcc agc atc tgc       2740
Val Val Phe Val Gly Gly Ile Thr Gln Thr Arg Asn Ala Ser Ile Cys           
810                 815                 820                 825           

caa gca gtt ggg ata att ctt cac tat tcc acc ctt gcc aca gta cta       2788
Gln Ala Val Gly Ile Ile Leu His Tyr Ser Thr Leu Ala Thr Val Leu           
                830                 835                 840               

tgg gta gga gtg aca gct cga aat atc tac aaa caa gtc act aaa aaa       2836
Trp Val Gly Val Thr Ala Arg Asn Ile Tyr Lys Gln Val Thr Lys Lys           
            845                 850                 855                   

gct aaa aga tgc cag gat cct gat gaa cca cca cct cca cca aga cca       2884
Ala Lys Arg Cys Gln Asp Pro Asp Glu Pro Pro Pro Pro Pro Arg Pro           
        860                 865                 870                       

atg ctc aga ttt tac ctg att ggt ggt ggt atc ccc atc att gtt tgc       2932
Met Leu Arg Phe Tyr Leu Ile Gly Gly Gly Ile Pro Ile Ile Val Cys           
    875                 880                 885                           

ggc ata act gca gca gcg aac att aag aat tac ggc agt cgg cca aac       2980
Gly Ile Thr Ala Ala Ala Asn Ile Lys Asn Tyr Gly Ser Arg Pro Asn           
890                 895                 900                 905           

gca ccc tat tgc tgg atg gca tgg gaa ccc tcc ttg gga gcc ttc tat       3028
Ala Pro Tyr Cys Trp Met Ala Trp Glu Pro Ser Leu Gly Ala Phe Tyr           
                910                 915                 920               

ggg cca gcc agc ttc atc act ttt gta aac tgc atg tac ttt ctg agc       3076
Gly Pro Ala Ser Phe Ile Thr Phe Val Asn Cys Met Tyr Phe Leu Ser           
            925                 930                 935                   

ata ttt att cag ttg aaa aga cac cct gag cgc aaa tat gag ctt aag       3124
Ile Phe Ile Gln Leu Lys Arg His Pro Glu Arg Lys Tyr Glu Leu Lys           
        940                 945                 950                       

gag ccc acg gag gag caa cag aga ttg gca gcc aat gaa aat ggc gaa       3172
Glu Pro Thr Glu Glu Gln Gln Arg Leu Ala Ala Asn Glu Asn Gly Glu           
    955                 960                 965                           

ata aat cat cag gat tca atg tct ttg tct ctg att tct aca tca gcc       3220
Ile Asn His Gln Asp Ser Met Ser Leu Ser Leu Ile Ser Thr Ser Ala           
970                 975                 980                 985           

ttg gaa aat gag cac act ttt cat tct cag ctc ttg ggg gcc agc  ctt      3268
Leu Glu Asn Glu His Thr Phe His Ser Gln Leu Leu Gly Ala Ser  Leu          
                990                 995                 1000              

act ttg ctc tta  tat gtt gca ctg tgg  atg ttt ggg gct ttg  gct        3313
Thr Leu Leu Leu  Tyr Val Ala Leu Trp  Met Phe Gly Ala Leu  Ala            
            1005                 1010                 1015                

gtt tct ttg tat  tac cct ttg gac ttg  gtt ttt agc ttc gtt  ttt        3358
Val Ser Leu Tyr  Tyr Pro Leu Asp Leu  Val Phe Ser Phe Val  Phe            
            1020                 1025                 1030                

gga gcc aca agt  tta agc ttc agt gcg  ttc ttc gtg gtc cac  cat        3403
Gly Ala Thr Ser  Leu Ser Phe Ser Ala  Phe Phe Val Val His  His            
            1035                 1040                 1045                

tgt gtt aat agg  gag gat gtt aga ctt  gcg tgg atc atg act  tgc        3448
Cys Val Asn Arg  Glu Asp Val Arg Leu  Ala Trp Ile Met Thr  Cys            
            1050                 1055                 1060                

tgc cca gga cgg  agc tcg tat tca gtg  caa gtc aac gtc cag  ccc        3493
Cys Pro Gly Arg  Ser Ser Tyr Ser Val  Gln Val Asn Val Gln  Pro            
            1065                 1070                 1075                

ccc aac tct aat  ggg acg aat gga gag  gca ccc aaa tgc ccc  aat        3538
Pro Asn Ser Asn  Gly Thr Asn Gly Glu  Ala Pro Lys Cys Pro  Asn            
            1080                 1085                 1090                

agc agt gcg gag  tct tca tgc aca aac  aaa agt gct tca agc  ttc        3583
Ser Ser Ala Glu  Ser Ser Cys Thr Asn  Lys Ser Ala Ser Ser  Phe            
            1095                 1100                 1105                

aaa aat tcc tcc  cag ggc tgc aaa tta  aca aac ttg cag gcg  gct        3628
Lys Asn Ser Ser  Gln Gly Cys Lys Leu  Thr Asn Leu Gln Ala  Ala            
            1110                 1115                 1120                

gca gct cag tgc  cat gcc aat tct tta  cct ttg aac tcc acc  cct        3673
Ala Ala Gln Cys  His Ala Asn Ser Leu  Pro Leu Asn Ser Thr  Pro            
            1125                 1130                 1135                

cag ctt gat aat  agt ctg aca gaa cat  tca atg gac aat gat  att        3718
Gln Leu Asp Asn  Ser Leu Thr Glu His  Ser Met Asp Asn Asp  Ile            
            1140                 1145                 1150                

aaa atg cac gtg  gcg cct tta gaa gtt  cag ttt cga aca aat  gtg        3763
Lys Met His Val  Ala Pro Leu Glu Val  Gln Phe Arg Thr Asn  Val            
            1155                 1160                 1165                

cac tca agc cgc  cac cat aaa aac aga  agt aaa gga cac cgg  gca        3808
His Ser Ser Arg  His His Lys Asn Arg  Ser Lys Gly His Arg  Ala            
            1170                 1175                 1180                

agc cga ctc aca  gtc ctg aga gaa tat  gcc tac gat gtc cca  acg        3853
Ser Arg Leu Thr  Val Leu Arg Glu Tyr  Ala Tyr Asp Val Pro  Thr            
            1185                 1190                 1195                

agc gtg gaa gga  agc gtg cag aac ggc  tta cct aaa agc cgg  ctg        3898
Ser Val Glu Gly  Ser Val Gln Asn Gly  Leu Pro Lys Ser Arg  Leu            
            1200                 1205                 1210                

ggc aat aac gaa  gga cac tcg agg agc  cga aga gct tat tta  gcc        3943
Gly Asn Asn Glu  Gly His Ser Arg Ser  Arg Arg Ala Tyr Leu  Ala            
            1215                 1220                 1225                

tac aga gag aga  cag tac aac cca ccc  cag caa gac agc agc  gat        3988
Tyr Arg Glu Arg  Gln Tyr Asn Pro Pro  Gln Gln Asp Ser Ser  Asp            
            1230                 1235                 1240                

gct tgt agc aca  ctt ccc aaa agt agc  aga aat ttt gaa aag  cca        4033
Ala Cys Ser Thr  Leu Pro Lys Ser Ser  Arg Asn Phe Glu Lys  Pro            
            1245                 1250                 1255                

gtt tca acc act  agt aaa aaa gat gcg  tta agg aag cca gct  gtg        4078
Val Ser Thr Thr  Ser Lys Lys Asp Ala  Leu Arg Lys Pro Ala  Val            
            1260                 1265                 1270                

gtt gaa ctt gaa  aat cag caa aaa tct  tat ggc ctc aac ttg  gcc        4123
Val Glu Leu Glu  Asn Gln Gln Lys Ser  Tyr Gly Leu Asn Leu  Ala            
            1275                 1280                 1285                

att cag aat gga  cca att aaa agc aat  ggg cag gag gga ccc  ttg        4168
Ile Gln Asn Gly  Pro Ile Lys Ser Asn  Gly Gln Glu Gly Pro  Leu            
            1290                 1295                 1300                

ctc ggt acc gat  agc act ggc aat gtt  agg act gga tta tgg  aaa        4213
Leu Gly Thr Asp  Ser Thr Gly Asn Val  Arg Thr Gly Leu Trp  Lys            
            1305                 1310                 1315                

cac gaa act act  gtg taa cattgctggg cttcctaggc agaaattcat             4261
His Glu Thr Thr  Val                                                      
            1320                                                          

ataaactgtg atactcacat tccttgaagc tatgagcatt taaaaactgt ttacagccac     4321

catagggatt caaaagaatt tggaataaac tttgaagttt tggattttac ttatttttat     4381

ccccaaattg ttgctatttt ttaggatctg aaacaaaatc tttctaaaac attgttttag     4441

ttgtcaaagc accaacagga cattttggga tgtgaaatgt aatttcttgg aatctgtaat     4501

ttgtacttaa tatttcaggc ttgtatttaa tataataaat aggtgtttgt tattgtgtca     4561

aaaaaaaaaa aaaaa                                                      4576


<210>  410
<211>  1321
<212>  PRT
<213>  Homo sapiens

<400>  410

Met Glu Pro Pro Gly Arg Arg Arg Gly Arg Ala Gln Pro Pro Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Ala Leu Leu Ala Leu Leu Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Ala Ala Leu Pro Ala Gly Cys Lys His Asp Gly Arg 
        35                  40                  45              


Pro Arg Gly Ala Gly Arg Ala Ala Gly Ala Ala Glu Gly Lys Val Val 
    50                  55                  60                  


Cys Ser Ser Leu Glu Leu Ala Gln Val Leu Pro Pro Asp Thr Leu Pro 
65                  70                  75                  80  


Asn Arg Thr Val Thr Leu Ile Leu Ser Asn Asn Lys Ile Ser Glu Leu 
                85                  90                  95      


Lys Asn Gly Ser Phe Ser Gly Leu Ser Leu Leu Glu Arg Leu Asp Leu 
            100                 105                 110         


Arg Asn Asn Leu Ile Ser Ser Ile Asp Pro Gly Ala Phe Trp Gly Leu 
        115                 120                 125             


Ser Ser Leu Lys Arg Leu Asp Leu Thr Asn Asn Arg Ile Gly Cys Leu 
    130                 135                 140                 


Asn Ala Asp Ile Phe Arg Gly Leu Thr Asn Leu Val Arg Leu Asn Leu 
145                 150                 155                 160 


Ser Gly Asn Leu Phe Ser Ser Leu Ser Gln Gly Thr Phe Asp Tyr Leu 
                165                 170                 175     


Ala Ser Leu Arg Ser Leu Glu Phe Gln Thr Glu Tyr Leu Leu Cys Asp 
            180                 185                 190         


Cys Asn Ile Leu Trp Met His Arg Trp Val Lys Glu Lys Asn Ile Thr 
        195                 200                 205             


Val Arg Asp Thr Arg Cys Val Tyr Pro Lys Ser Leu Gln Ala Gln Pro 
    210                 215                 220                 


Val Thr Gly Val Lys Gln Glu Leu Leu Thr Cys Asp Pro Pro Leu Glu 
225                 230                 235                 240 


Leu Pro Ser Phe Tyr Met Thr Pro Ser His Arg Gln Val Val Phe Glu 
                245                 250                 255     


Gly Asp Ser Leu Pro Phe Gln Cys Met Ala Ser Tyr Ile Asp Gln Asp 
            260                 265                 270         


Met Gln Val Leu Trp Tyr Gln Asp Gly Arg Ile Val Glu Thr Asp Glu 
        275                 280                 285             


Ser Gln Gly Ile Phe Val Glu Lys Asn Met Ile His Asn Cys Ser Leu 
    290                 295                 300                 


Ile Ala Ser Ala Leu Thr Ile Ser Asn Ile Gln Ala Gly Ser Thr Gly 
305                 310                 315                 320 


Asn Trp Gly Cys His Val Gln Thr Lys Arg Gly Asn Asn Thr Arg Thr 
                325                 330                 335     


Val Asp Ile Val Val Leu Glu Ser Ser Ala Gln Tyr Cys Pro Pro Glu 
            340                 345                 350         


Arg Val Val Asn Asn Lys Gly Asp Phe Arg Trp Pro Arg Thr Leu Ala 
        355                 360                 365             


Gly Ile Thr Ala Tyr Leu Gln Cys Thr Arg Asn Thr His Gly Ser Gly 
    370                 375                 380                 


Ile Tyr Pro Gly Asn Pro Gln Asp Glu Arg Lys Ala Trp Arg Arg Cys 
385                 390                 395                 400 


Asp Arg Gly Gly Phe Trp Ala Asp Asp Asp Tyr Ser Arg Cys Gln Tyr 
                405                 410                 415     


Ala Asn Asp Val Thr Arg Val Leu Tyr Met Phe Asn Gln Met Pro Leu 
            420                 425                 430         


Asn Leu Thr Asn Ala Val Ala Thr Ala Arg Gln Leu Leu Ala Tyr Thr 
        435                 440                 445             


Val Glu Ala Ala Asn Phe Ser Asp Lys Met Asp Val Ile Phe Val Ala 
    450                 455                 460                 


Glu Met Ile Glu Lys Phe Gly Arg Phe Thr Lys Glu Glu Lys Ser Lys 
465                 470                 475                 480 


Glu Leu Gly Asp Val Met Val Asp Ile Ala Ser Asn Ile Met Leu Ala 
                485                 490                 495     


Asp Glu Arg Val Leu Trp Leu Ala Gln Arg Glu Ala Lys Ala Cys Ser 
            500                 505                 510         


Arg Ile Val Gln Cys Leu Gln Arg Ile Ala Thr Tyr Arg Leu Ala Gly 
        515                 520                 525             


Gly Ala His Val Tyr Ser Thr Tyr Ser Pro Asn Ile Ala Leu Glu Ala 
    530                 535                 540                 


Tyr Val Ile Lys Ser Thr Gly Phe Thr Gly Met Thr Cys Thr Val Phe 
545                 550                 555                 560 


Gln Lys Val Ala Ala Ser Asp Arg Thr Gly Leu Ser Asp Tyr Gly Arg 
                565                 570                 575     


Arg Asp Pro Glu Gly Asn Leu Asp Lys Gln Leu Ser Phe Lys Cys Asn 
            580                 585                 590         


Val Ser Asn Thr Phe Ser Ser Leu Ala Leu Lys Asn Thr Ile Val Glu 
        595                 600                 605             


Ala Ser Ile Gln Leu Pro Pro Ser Leu Phe Ser Pro Lys Gln Lys Arg 
    610                 615                 620                 


Glu Leu Arg Pro Thr Asp Asp Ser Leu Tyr Lys Leu Gln Leu Ile Ala 
625                 630                 635                 640 


Phe Arg Asn Gly Lys Leu Phe Pro Ala Thr Gly Asn Ser Thr Asn Leu 
                645                 650                 655     


Ala Asp Asp Gly Lys Arg Arg Thr Val Val Thr Pro Val Ile Leu Thr 
            660                 665                 670         


Lys Ile Asp Gly Val Asn Val Asp Thr His His Ile Pro Val Asn Val 
        675                 680                 685             


Thr Leu Arg Arg Ile Ala His Gly Ala Asp Ala Val Ala Ala Arg Trp 
    690                 695                 700                 


Asp Phe Asp Leu Leu Asn Gly Gln Gly Gly Trp Lys Ser Asp Gly Cys 
705                 710                 715                 720 


His Ile Leu Tyr Ser Asp Glu Asn Ile Thr Thr Ile Gln Cys Tyr Ser 
                725                 730                 735     


Leu Ser Asn Tyr Ala Val Leu Met Asp Leu Thr Gly Ser Glu Leu Tyr 
            740                 745                 750         


Thr Gln Ala Ala Ser Leu Leu His Pro Val Val Tyr Thr Thr Ala Ile 
        755                 760                 765             


Ile Leu Leu Leu Cys Leu Leu Ala Val Ile Val Ser Tyr Ile Tyr His 
    770                 775                 780                 


His Ser Leu Ile Arg Ile Ser Leu Lys Ser Trp His Met Leu Val Asn 
785                 790                 795                 800 


Leu Cys Phe His Ile Phe Leu Thr Cys Val Val Phe Val Gly Gly Ile 
                805                 810                 815     


Thr Gln Thr Arg Asn Ala Ser Ile Cys Gln Ala Val Gly Ile Ile Leu 
            820                 825                 830         


His Tyr Ser Thr Leu Ala Thr Val Leu Trp Val Gly Val Thr Ala Arg 
        835                 840                 845             


Asn Ile Tyr Lys Gln Val Thr Lys Lys Ala Lys Arg Cys Gln Asp Pro 
    850                 855                 860                 


Asp Glu Pro Pro Pro Pro Pro Arg Pro Met Leu Arg Phe Tyr Leu Ile 
865                 870                 875                 880 


Gly Gly Gly Ile Pro Ile Ile Val Cys Gly Ile Thr Ala Ala Ala Asn 
                885                 890                 895     


Ile Lys Asn Tyr Gly Ser Arg Pro Asn Ala Pro Tyr Cys Trp Met Ala 
            900                 905                 910         


Trp Glu Pro Ser Leu Gly Ala Phe Tyr Gly Pro Ala Ser Phe Ile Thr 
        915                 920                 925             


Phe Val Asn Cys Met Tyr Phe Leu Ser Ile Phe Ile Gln Leu Lys Arg 
    930                 935                 940                 


His Pro Glu Arg Lys Tyr Glu Leu Lys Glu Pro Thr Glu Glu Gln Gln 
945                 950                 955                 960 


Arg Leu Ala Ala Asn Glu Asn Gly Glu Ile Asn His Gln Asp Ser Met 
                965                 970                 975     


Ser Leu Ser Leu Ile Ser Thr Ser Ala Leu Glu Asn Glu His Thr Phe 
            980                 985                 990         


His Ser Gln Leu Leu Gly Ala Ser  Leu Thr Leu Leu Leu  Tyr Val Ala 
        995                 1000                 1005             


Leu Trp  Met Phe Gly Ala Leu  Ala Val Ser Leu Tyr  Tyr Pro Leu 
    1010                 1015                 1020             


Asp Leu  Val Phe Ser Phe Val  Phe Gly Ala Thr Ser  Leu Ser Phe 
    1025                 1030                 1035             


Ser Ala  Phe Phe Val Val His  His Cys Val Asn Arg  Glu Asp Val 
    1040                 1045                 1050             


Arg Leu  Ala Trp Ile Met Thr  Cys Cys Pro Gly Arg  Ser Ser Tyr 
    1055                 1060                 1065             


Ser Val  Gln Val Asn Val Gln  Pro Pro Asn Ser Asn  Gly Thr Asn 
    1070                 1075                 1080             


Gly Glu  Ala Pro Lys Cys Pro  Asn Ser Ser Ala Glu  Ser Ser Cys 
    1085                 1090                 1095             


Thr Asn  Lys Ser Ala Ser Ser  Phe Lys Asn Ser Ser  Gln Gly Cys 
    1100                 1105                 1110             


Lys Leu  Thr Asn Leu Gln Ala  Ala Ala Ala Gln Cys  His Ala Asn 
    1115                 1120                 1125             


Ser Leu  Pro Leu Asn Ser Thr  Pro Gln Leu Asp Asn  Ser Leu Thr 
    1130                 1135                 1140             


Glu His  Ser Met Asp Asn Asp  Ile Lys Met His Val  Ala Pro Leu 
    1145                 1150                 1155             


Glu Val  Gln Phe Arg Thr Asn  Val His Ser Ser Arg  His His Lys 
    1160                 1165                 1170             


Asn Arg  Ser Lys Gly His Arg  Ala Ser Arg Leu Thr  Val Leu Arg 
    1175                 1180                 1185             


Glu Tyr  Ala Tyr Asp Val Pro  Thr Ser Val Glu Gly  Ser Val Gln 
    1190                 1195                 1200             


Asn Gly  Leu Pro Lys Ser Arg  Leu Gly Asn Asn Glu  Gly His Ser 
    1205                 1210                 1215             


Arg Ser  Arg Arg Ala Tyr Leu  Ala Tyr Arg Glu Arg  Gln Tyr Asn 
    1220                 1225                 1230             


Pro Pro  Gln Gln Asp Ser Ser  Asp Ala Cys Ser Thr  Leu Pro Lys 
    1235                 1240                 1245             


Ser Ser  Arg Asn Phe Glu Lys  Pro Val Ser Thr Thr  Ser Lys Lys 
    1250                 1255                 1260             


Asp Ala  Leu Arg Lys Pro Ala  Val Val Glu Leu Glu  Asn Gln Gln 
    1265                 1270                 1275             


Lys Ser  Tyr Gly Leu Asn Leu  Ala Ile Gln Asn Gly  Pro Ile Lys 
    1280                 1285                 1290             


Ser Asn  Gly Gln Glu Gly Pro  Leu Leu Gly Thr Asp  Ser Thr Gly 
    1295                 1300                 1305             


Asn Val  Arg Thr Gly Leu Trp  Lys His Glu Thr Thr  Val 
    1310                 1315                 1320     


<210>  411
<211>  4076
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (397)..(3666)

<400>  411
tctcccgaga acctcacccc ccggtattcc cctcaccctg aagtaaggga gtctccctct       60

tcccctcagc tcctaaccaa ggtgctcagt accgcggcta gggtgcccag cgggaggctg      120

ggtagttacc ggaggaggca gagccggtcg cacgcctggg tcccagcgga ggcccagtcg      180

actctcgacc cgggccccag cctccttgcg tggcgaaggt cgtgcctcag gtctcctggc      240

gaacctggcc gcccggaagc ggagagtgac tcctcccctt cgtcccctcg gtgcccgcca      300

ggcggcgccg tcggctgggc ccggattccc ctgcggcttc gatccctttc cactgggtat      360

tgagattggc gaggggagag gcgcagaaac ggcgtg atg cag aaa gcc tca gtg        414
                                        Met Gln Lys Ala Ser Val           
                                        1               5                 

ttg ctc ttc ctg gcc tgg gtc tgc ttc ctc ttc tac gct ggc att gcc        462
Leu Leu Phe Leu Ala Trp Val Cys Phe Leu Phe Tyr Ala Gly Ile Ala           
            10                  15                  20                    

ctc ttc acc agt ggc ttc ctg ctc acc cgt ttg gag ctc acc aac cat        510
Leu Phe Thr Ser Gly Phe Leu Leu Thr Arg Leu Glu Leu Thr Asn His           
        25                  30                  35                        

agc agc tgc caa gag ccc cca ggc cct ggg tcc ctg cca tgg ggg agc        558
Ser Ser Cys Gln Glu Pro Pro Gly Pro Gly Ser Leu Pro Trp Gly Ser           
    40                  45                  50                            

caa ggg aaa cct ggg gcc tgc tgg atg gct tcc cga ttt tcg cgg gtt        606
Gln Gly Lys Pro Gly Ala Cys Trp Met Ala Ser Arg Phe Ser Arg Val           
55                  60                  65                  70            

gtg ttg gtg ctg ata gat gct ctg cga ttt gac ttc gcc cag ccc cag        654
Val Leu Val Leu Ile Asp Ala Leu Arg Phe Asp Phe Ala Gln Pro Gln           
                75                  80                  85                

cat tca cac gtg cct aga gag cct cct gtc tcc cta ccc ttc ctg ggc        702
His Ser His Val Pro Arg Glu Pro Pro Val Ser Leu Pro Phe Leu Gly           
            90                  95                  100                   

aaa cta agc tcc ttg cag agg atc ctg gag att cag ccc cac cat gcc        750
Lys Leu Ser Ser Leu Gln Arg Ile Leu Glu Ile Gln Pro His His Ala           
        105                 110                 115                       

cgg ctc tac cga tct cag gtt gac cct cct acc acc acc atg cag cgc        798
Arg Leu Tyr Arg Ser Gln Val Asp Pro Pro Thr Thr Thr Met Gln Arg           
    120                 125                 130                           

ctc aag gcc ctc acc act ggc tca ctg cct acc ttt att gat gct ggt        846
Leu Lys Ala Leu Thr Thr Gly Ser Leu Pro Thr Phe Ile Asp Ala Gly           
135                 140                 145                 150           

agt aac ttc gcc agc cac gcc ata gtg gaa gac aat ctc att aag cag        894
Ser Asn Phe Ala Ser His Ala Ile Val Glu Asp Asn Leu Ile Lys Gln           
                155                 160                 165               

ctc acc agt gca gga agg cgt gta gtc ttc atg gga gat gat acc tgg        942
Leu Thr Ser Ala Gly Arg Arg Val Val Phe Met Gly Asp Asp Thr Trp           
            170                 175                 180                   

aaa gac ctt ttc cct ggt gct ttc tcc aaa gct ttc ttc ttc cca tcc        990
Lys Asp Leu Phe Pro Gly Ala Phe Ser Lys Ala Phe Phe Phe Pro Ser           
        185                 190                 195                       

ttc aat gtc aga gac cta gac aca gtg gac aat ggc atc ctg gaa cac       1038
Phe Asn Val Arg Asp Leu Asp Thr Val Asp Asn Gly Ile Leu Glu His           
    200                 205                 210                           

ctc tac ccc acc atg gac agt ggt gaa tgg gac gtg ctg att gct cac       1086
Leu Tyr Pro Thr Met Asp Ser Gly Glu Trp Asp Val Leu Ile Ala His           
215                 220                 225                 230           

ttc ctg ggt gtg gac cac tgt ggc cac aag cat ggc cct cac cac cct       1134
Phe Leu Gly Val Asp His Cys Gly His Lys His Gly Pro His His Pro           
                235                 240                 245               

gaa atg gcc aag aaa ctt agc cag atg gac cag gtg atc cag gga ctt       1182
Glu Met Ala Lys Lys Leu Ser Gln Met Asp Gln Val Ile Gln Gly Leu           
            250                 255                 260                   

gtg gag cgt ctg gag aat gac aca ctg ctg gta gtg gct ggg gac cat       1230
Val Glu Arg Leu Glu Asn Asp Thr Leu Leu Val Val Ala Gly Asp His           
        265                 270                 275                       

ggg atg acc aca aat gga gac cat gga ggg gac agt gag ctg gag gtc       1278
Gly Met Thr Thr Asn Gly Asp His Gly Gly Asp Ser Glu Leu Glu Val           
    280                 285                 290                           

tca gct gct ctc ttt ctg tat agc ccc aca gca gtc ttc ccc agc acc       1326
Ser Ala Ala Leu Phe Leu Tyr Ser Pro Thr Ala Val Phe Pro Ser Thr           
295                 300                 305                 310           

cca cca gag gag cca gag gtg att cct caa gtt agc ctt gtg ccc acg       1374
Pro Pro Glu Glu Pro Glu Val Ile Pro Gln Val Ser Leu Val Pro Thr           
                315                 320                 325               

ctg gcc ctg ctg ctg ggc ctg ccc atc cca ttt ggg aat atc ggg gaa       1422
Leu Ala Leu Leu Leu Gly Leu Pro Ile Pro Phe Gly Asn Ile Gly Glu           
            330                 335                 340                   

gtg atg gct gag cta ttc tca ggg ggt gag gac tcc cag ccc cac tcc       1470
Val Met Ala Glu Leu Phe Ser Gly Gly Glu Asp Ser Gln Pro His Ser           
        345                 350                 355                       

tct gct tta gcc caa gcc tca gct ctc cat ctc aat gct cag cag gtg       1518
Ser Ala Leu Ala Gln Ala Ser Ala Leu His Leu Asn Ala Gln Gln Val           
    360                 365                 370                           

tcc cga ttt ctt cat acc tac tca gct gct act cag gac ctt caa gct       1566
Ser Arg Phe Leu His Thr Tyr Ser Ala Ala Thr Gln Asp Leu Gln Ala           
375                 380                 385                 390           

aag gag ctt cat cag ctg cag aac ctc ttc tcc aag gcc tct gct gac       1614
Lys Glu Leu His Gln Leu Gln Asn Leu Phe Ser Lys Ala Ser Ala Asp           
                395                 400                 405               

tac cag tgg ctt ctc cag agc ccc aag ggg gct gag gcg aca ctg ccg       1662
Tyr Gln Trp Leu Leu Gln Ser Pro Lys Gly Ala Glu Ala Thr Leu Pro           
            410                 415                 420                   

act gtg att gct gag ctg cag cag ttc ctg cgg gga gct cgg gcc atg       1710
Thr Val Ile Ala Glu Leu Gln Gln Phe Leu Arg Gly Ala Arg Ala Met           
        425                 430                 435                       

tgc atc gag tct tgg gct cgt ttc tct ctg gtc cgc atg gcg ggg ggt       1758
Cys Ile Glu Ser Trp Ala Arg Phe Ser Leu Val Arg Met Ala Gly Gly           
    440                 445                 450                           

act gct ctc ttg gct gct tcc tgc ttt atc tgc ctg ctg gca tct cag       1806
Thr Ala Leu Leu Ala Ala Ser Cys Phe Ile Cys Leu Leu Ala Ser Gln           
455                 460                 465                 470           

tgg gca ata tcc cca ggc ttt cca ttc tgc cct cta ctc ctg aca cct       1854
Trp Ala Ile Ser Pro Gly Phe Pro Phe Cys Pro Leu Leu Leu Thr Pro           
                475                 480                 485               

gtg gcc tgg ggc ctg gtt ggg gcc ata gcg tat gct gga ctc ctg gga       1902
Val Ala Trp Gly Leu Val Gly Ala Ile Ala Tyr Ala Gly Leu Leu Gly           
            490                 495                 500                   

act att gag ctg aag cta gat cta gtg ctt cta ggg gct gtg gct gca       1950
Thr Ile Glu Leu Lys Leu Asp Leu Val Leu Leu Gly Ala Val Ala Ala           
        505                 510                 515                       

gtg agc tca ttc ctc cct ttt ctg tgg aaa gcc tgg gct ggc tgg ggg       1998
Val Ser Ser Phe Leu Pro Phe Leu Trp Lys Ala Trp Ala Gly Trp Gly           
    520                 525                 530                           

tcc aag agg ccc ctg gca acc ctg ttt ccc atc cct ggg ccc gtc ctg       2046
Ser Lys Arg Pro Leu Ala Thr Leu Phe Pro Ile Pro Gly Pro Val Leu           
535                 540                 545                 550           

tta ctc ctg ctg ttt cgc ttg gct gtg ttc ttc tct gat agt ttt gtt       2094
Leu Leu Leu Leu Phe Arg Leu Ala Val Phe Phe Ser Asp Ser Phe Val           
                555                 560                 565               

gta gct gag gcc agg gcc acc ccc ttc ctt ttg ggc tca ttc atc ctg       2142
Val Ala Glu Ala Arg Ala Thr Pro Phe Leu Leu Gly Ser Phe Ile Leu           
            570                 575                 580                   

ctc ctg gtt gtc cag ctt cac tgg gag ggc cag ctg ctt cca cct aag       2190
Leu Leu Val Val Gln Leu His Trp Glu Gly Gln Leu Leu Pro Pro Lys           
        585                 590                 595                       

cta ctc aca atg ccc cgc ctt ggc act tca gcc aca aca aac ccc cca       2238
Leu Leu Thr Met Pro Arg Leu Gly Thr Ser Ala Thr Thr Asn Pro Pro           
    600                 605                 610                           

cgg cac aat ggt gca tat gcc ctg agg ctt gga att ggg ttg ctt tta       2286
Arg His Asn Gly Ala Tyr Ala Leu Arg Leu Gly Ile Gly Leu Leu Leu           
615                 620                 625                 630           

tgt aca agg cta gct ggg ctt ttt cat cgt tgc cct gaa gag aca cct       2334
Cys Thr Arg Leu Ala Gly Leu Phe His Arg Cys Pro Glu Glu Thr Pro           
                635                 640                 645               

gtt tgc cac tcc tct ccc tgg ctg agt cct ctg gca tcc atg gtg ggt       2382
Val Cys His Ser Ser Pro Trp Leu Ser Pro Leu Ala Ser Met Val Gly           
            650                 655                 660                   

ggt cga gcc aag aat ttg tgg tat gga gct tgt gtg gcg gcg ctg gtg       2430
Gly Arg Ala Lys Asn Leu Trp Tyr Gly Ala Cys Val Ala Ala Leu Val           
        665                 670                 675                       

gcc ctg tta gct gcc gtg cgc ttg tgg ctt cgc cgc tat ggt aat ctc       2478
Ala Leu Leu Ala Ala Val Arg Leu Trp Leu Arg Arg Tyr Gly Asn Leu           
    680                 685                 690                           

aag agc ccc gag cca ccc atg ctc ttt gtg cgc tgg gga ctg ccc cta       2526
Lys Ser Pro Glu Pro Pro Met Leu Phe Val Arg Trp Gly Leu Pro Leu           
695                 700                 705                 710           

atg gca ttg ggt act gct gcc tac tgg gca ttg gcg tcg ggg gca gat       2574
Met Ala Leu Gly Thr Ala Ala Tyr Trp Ala Leu Ala Ser Gly Ala Asp           
                715                 720                 725               

gag gct ccc ccc cgt ctc cgg gtc ctg gtc tct ggg gca tcc atg gtg       2622
Glu Ala Pro Pro Arg Leu Arg Val Leu Val Ser Gly Ala Ser Met Val           
            730                 735                 740                   

ctg cct cgg gct gta gca ggg ctg gct gct tca ggg ctc gcg ctg ctg       2670
Leu Pro Arg Ala Val Ala Gly Leu Ala Ala Ser Gly Leu Ala Leu Leu           
        745                 750                 755                       

ctc tgg aag cct gtg aca gtg ctg gtg aag gct ggg gca ggc gct cca       2718
Leu Trp Lys Pro Val Thr Val Leu Val Lys Ala Gly Ala Gly Ala Pro           
    760                 765                 770                           

agg acc agg act gtc ctc act ccc ttc tca ggc ccc ccc act tct caa       2766
Arg Thr Arg Thr Val Leu Thr Pro Phe Ser Gly Pro Pro Thr Ser Gln           
775                 780                 785                 790           

gct gac ttg gat tat gtg gtc cct caa atc tac cga cac atg cag gag       2814
Ala Asp Leu Asp Tyr Val Val Pro Gln Ile Tyr Arg His Met Gln Glu           
                795                 800                 805               

gag ttc cgg ggc cgg tta gag agg acc aaa tct cag ggt ccc ctg act       2862
Glu Phe Arg Gly Arg Leu Glu Arg Thr Lys Ser Gln Gly Pro Leu Thr           
            810                 815                 820                   

gtg gct gct tat cag ttg ggg agt gtc tac tca gct gct atg gtc aca       2910
Val Ala Ala Tyr Gln Leu Gly Ser Val Tyr Ser Ala Ala Met Val Thr           
        825                 830                 835                       

gcc ctc acc ctg ttg gcc ttc cca ctt ctg ctg ttg cat gcg gag cgc       2958
Ala Leu Thr Leu Leu Ala Phe Pro Leu Leu Leu Leu His Ala Glu Arg           
    840                 845                 850                           

atc agc ctt gtg ttc ctg ctt ctg ttt ctg cag agc ttc ctt ctc cta       3006
Ile Ser Leu Val Phe Leu Leu Leu Phe Leu Gln Ser Phe Leu Leu Leu           
855                 860                 865                 870           

cat ctg ctt gct gct ggg ata ccc gtc acc acc cct ggt cct ttt act       3054
His Leu Leu Ala Ala Gly Ile Pro Val Thr Thr Pro Gly Pro Phe Thr           
                875                 880                 885               

gtg cca tgg cag gca gtc tcg gct tgg gcc ctc atg gcc aca cag acc       3102
Val Pro Trp Gln Ala Val Ser Ala Trp Ala Leu Met Ala Thr Gln Thr           
            890                 895                 900                   

ttc tac tcc aca ggc cac cag cct gtc ttt cca gcc atc cat tgg cat       3150
Phe Tyr Ser Thr Gly His Gln Pro Val Phe Pro Ala Ile His Trp His           
        905                 910                 915                       

gca gcc ttc gtg gga ttc cca gag ggt cat ggc tcc tgt act tgg ctg       3198
Ala Ala Phe Val Gly Phe Pro Glu Gly His Gly Ser Cys Thr Trp Leu           
    920                 925                 930                           

cct gct ttg cta gtg gga gcc aac acc ttt gcc tcc cac ctc ctc ttt       3246
Pro Ala Leu Leu Val Gly Ala Asn Thr Phe Ala Ser His Leu Leu Phe           
935                 940                 945                 950           

gca gta ggt tgc cca ctg ctc ctg ctc tgg cct ttc ctg tgt gag agt       3294
Ala Val Gly Cys Pro Leu Leu Leu Leu Trp Pro Phe Leu Cys Glu Ser           
                955                 960                 965               

caa ggg ctg cgg aag aga cag cag ccc cca ggg aat gaa gct gat gcc       3342
Gln Gly Leu Arg Lys Arg Gln Gln Pro Pro Gly Asn Glu Ala Asp Ala           
            970                 975                 980                   

aga gtc aga ccc gag gag gaa gag gag cca ctg atg gag atg cgg ctc       3390
Arg Val Arg Pro Glu Glu Glu Glu Glu Pro Leu Met Glu Met Arg Leu           
        985                 990                 995                       

cgg gat  gcg cct cag cac ttc  tat gca gca ctg ctg  cag ctg ggc        3435
Arg Asp  Ala Pro Gln His Phe  Tyr Ala Ala Leu Leu  Gln Leu Gly            
    1000                 1005                 1010                        

ctc aag  tac ctc ttt atc ctt  ggt att cag att ctg  gcc tgt gcc        3480
Leu Lys  Tyr Leu Phe Ile Leu  Gly Ile Gln Ile Leu  Ala Cys Ala            
    1015                 1020                 1025                        

ttg gca  gcc tcc atc ctt cgc  agg cat ctc atg gtc  tgg aaa gtg        3525
Leu Ala  Ala Ser Ile Leu Arg  Arg His Leu Met Val  Trp Lys Val            
    1030                 1035                 1040                        

ttt gcc  cct aag ttc ata ttt  gag gct gtg ggc ttc  att gtg agc        3570
Phe Ala  Pro Lys Phe Ile Phe  Glu Ala Val Gly Phe  Ile Val Ser            
    1045                 1050                 1055                        

agc gtg  gga ctt ctc ctg ggc  ata gct ttg gtg atg  aga gtg gat        3615
Ser Val  Gly Leu Leu Leu Gly  Ile Ala Leu Val Met  Arg Val Asp            
    1060                 1065                 1070                        

ggt gct  gtg agc tcc tgg ttc  agg cag cta ttt ctg  gcc cag cag        3660
Gly Ala  Val Ser Ser Trp Phe  Arg Gln Leu Phe Leu  Ala Gln Gln            
    1075                 1080                 1085                        

agg tag cctagtctgt gattactggc acttggctac agagagtgct ggagaacagt        3716
Arg                                                                       
                                                                          

gtagcctggc ctgtacaggt actggatgat ctgcaagaca ggctcagcca tactcttact     3776

atcatgcagc caggggccgc tgacatctag gacttcatta ttctataatt caggaccaca     3836

gtggagtatg atccctaact cctgatttgg atgcatctga gggacaaggg gggcggtctc     3896

cgaagtggaa taaaataggc cgggcgtggt gacttgcacc tataatccca gcactttggg     3956

aggcagaggt gggaggattg cttggtccca ggagttcaag accagcctgt ggaacataac     4016

aagaccccgt ctctactatt taaaaaaaag tgtaataaaa tgataatata aaaaaaaaaa     4076


<210>  412
<211>  1089
<212>  PRT
<213>  Homo sapiens

<400>  412

Met Gln Lys Ala Ser Val Leu Leu Phe Leu Ala Trp Val Cys Phe Leu 
1               5                   10                  15      


Phe Tyr Ala Gly Ile Ala Leu Phe Thr Ser Gly Phe Leu Leu Thr Arg 
            20                  25                  30          


Leu Glu Leu Thr Asn His Ser Ser Cys Gln Glu Pro Pro Gly Pro Gly 
        35                  40                  45              


Ser Leu Pro Trp Gly Ser Gln Gly Lys Pro Gly Ala Cys Trp Met Ala 
    50                  55                  60                  


Ser Arg Phe Ser Arg Val Val Leu Val Leu Ile Asp Ala Leu Arg Phe 
65                  70                  75                  80  


Asp Phe Ala Gln Pro Gln His Ser His Val Pro Arg Glu Pro Pro Val 
                85                  90                  95      


Ser Leu Pro Phe Leu Gly Lys Leu Ser Ser Leu Gln Arg Ile Leu Glu 
            100                 105                 110         


Ile Gln Pro His His Ala Arg Leu Tyr Arg Ser Gln Val Asp Pro Pro 
        115                 120                 125             


Thr Thr Thr Met Gln Arg Leu Lys Ala Leu Thr Thr Gly Ser Leu Pro 
    130                 135                 140                 


Thr Phe Ile Asp Ala Gly Ser Asn Phe Ala Ser His Ala Ile Val Glu 
145                 150                 155                 160 


Asp Asn Leu Ile Lys Gln Leu Thr Ser Ala Gly Arg Arg Val Val Phe 
                165                 170                 175     


Met Gly Asp Asp Thr Trp Lys Asp Leu Phe Pro Gly Ala Phe Ser Lys 
            180                 185                 190         


Ala Phe Phe Phe Pro Ser Phe Asn Val Arg Asp Leu Asp Thr Val Asp 
        195                 200                 205             


Asn Gly Ile Leu Glu His Leu Tyr Pro Thr Met Asp Ser Gly Glu Trp 
    210                 215                 220                 


Asp Val Leu Ile Ala His Phe Leu Gly Val Asp His Cys Gly His Lys 
225                 230                 235                 240 


His Gly Pro His His Pro Glu Met Ala Lys Lys Leu Ser Gln Met Asp 
                245                 250                 255     


Gln Val Ile Gln Gly Leu Val Glu Arg Leu Glu Asn Asp Thr Leu Leu 
            260                 265                 270         


Val Val Ala Gly Asp His Gly Met Thr Thr Asn Gly Asp His Gly Gly 
        275                 280                 285             


Asp Ser Glu Leu Glu Val Ser Ala Ala Leu Phe Leu Tyr Ser Pro Thr 
    290                 295                 300                 


Ala Val Phe Pro Ser Thr Pro Pro Glu Glu Pro Glu Val Ile Pro Gln 
305                 310                 315                 320 


Val Ser Leu Val Pro Thr Leu Ala Leu Leu Leu Gly Leu Pro Ile Pro 
                325                 330                 335     


Phe Gly Asn Ile Gly Glu Val Met Ala Glu Leu Phe Ser Gly Gly Glu 
            340                 345                 350         


Asp Ser Gln Pro His Ser Ser Ala Leu Ala Gln Ala Ser Ala Leu His 
        355                 360                 365             


Leu Asn Ala Gln Gln Val Ser Arg Phe Leu His Thr Tyr Ser Ala Ala 
    370                 375                 380                 


Thr Gln Asp Leu Gln Ala Lys Glu Leu His Gln Leu Gln Asn Leu Phe 
385                 390                 395                 400 


Ser Lys Ala Ser Ala Asp Tyr Gln Trp Leu Leu Gln Ser Pro Lys Gly 
                405                 410                 415     


Ala Glu Ala Thr Leu Pro Thr Val Ile Ala Glu Leu Gln Gln Phe Leu 
            420                 425                 430         


Arg Gly Ala Arg Ala Met Cys Ile Glu Ser Trp Ala Arg Phe Ser Leu 
        435                 440                 445             


Val Arg Met Ala Gly Gly Thr Ala Leu Leu Ala Ala Ser Cys Phe Ile 
    450                 455                 460                 


Cys Leu Leu Ala Ser Gln Trp Ala Ile Ser Pro Gly Phe Pro Phe Cys 
465                 470                 475                 480 


Pro Leu Leu Leu Thr Pro Val Ala Trp Gly Leu Val Gly Ala Ile Ala 
                485                 490                 495     


Tyr Ala Gly Leu Leu Gly Thr Ile Glu Leu Lys Leu Asp Leu Val Leu 
            500                 505                 510         


Leu Gly Ala Val Ala Ala Val Ser Ser Phe Leu Pro Phe Leu Trp Lys 
        515                 520                 525             


Ala Trp Ala Gly Trp Gly Ser Lys Arg Pro Leu Ala Thr Leu Phe Pro 
    530                 535                 540                 


Ile Pro Gly Pro Val Leu Leu Leu Leu Leu Phe Arg Leu Ala Val Phe 
545                 550                 555                 560 


Phe Ser Asp Ser Phe Val Val Ala Glu Ala Arg Ala Thr Pro Phe Leu 
                565                 570                 575     


Leu Gly Ser Phe Ile Leu Leu Leu Val Val Gln Leu His Trp Glu Gly 
            580                 585                 590         


Gln Leu Leu Pro Pro Lys Leu Leu Thr Met Pro Arg Leu Gly Thr Ser 
        595                 600                 605             


Ala Thr Thr Asn Pro Pro Arg His Asn Gly Ala Tyr Ala Leu Arg Leu 
    610                 615                 620                 


Gly Ile Gly Leu Leu Leu Cys Thr Arg Leu Ala Gly Leu Phe His Arg 
625                 630                 635                 640 


Cys Pro Glu Glu Thr Pro Val Cys His Ser Ser Pro Trp Leu Ser Pro 
                645                 650                 655     


Leu Ala Ser Met Val Gly Gly Arg Ala Lys Asn Leu Trp Tyr Gly Ala 
            660                 665                 670         


Cys Val Ala Ala Leu Val Ala Leu Leu Ala Ala Val Arg Leu Trp Leu 
        675                 680                 685             


Arg Arg Tyr Gly Asn Leu Lys Ser Pro Glu Pro Pro Met Leu Phe Val 
    690                 695                 700                 


Arg Trp Gly Leu Pro Leu Met Ala Leu Gly Thr Ala Ala Tyr Trp Ala 
705                 710                 715                 720 


Leu Ala Ser Gly Ala Asp Glu Ala Pro Pro Arg Leu Arg Val Leu Val 
                725                 730                 735     


Ser Gly Ala Ser Met Val Leu Pro Arg Ala Val Ala Gly Leu Ala Ala 
            740                 745                 750         


Ser Gly Leu Ala Leu Leu Leu Trp Lys Pro Val Thr Val Leu Val Lys 
        755                 760                 765             


Ala Gly Ala Gly Ala Pro Arg Thr Arg Thr Val Leu Thr Pro Phe Ser 
    770                 775                 780                 


Gly Pro Pro Thr Ser Gln Ala Asp Leu Asp Tyr Val Val Pro Gln Ile 
785                 790                 795                 800 


Tyr Arg His Met Gln Glu Glu Phe Arg Gly Arg Leu Glu Arg Thr Lys 
                805                 810                 815     


Ser Gln Gly Pro Leu Thr Val Ala Ala Tyr Gln Leu Gly Ser Val Tyr 
            820                 825                 830         


Ser Ala Ala Met Val Thr Ala Leu Thr Leu Leu Ala Phe Pro Leu Leu 
        835                 840                 845             


Leu Leu His Ala Glu Arg Ile Ser Leu Val Phe Leu Leu Leu Phe Leu 
    850                 855                 860                 


Gln Ser Phe Leu Leu Leu His Leu Leu Ala Ala Gly Ile Pro Val Thr 
865                 870                 875                 880 


Thr Pro Gly Pro Phe Thr Val Pro Trp Gln Ala Val Ser Ala Trp Ala 
                885                 890                 895     


Leu Met Ala Thr Gln Thr Phe Tyr Ser Thr Gly His Gln Pro Val Phe 
            900                 905                 910         


Pro Ala Ile His Trp His Ala Ala Phe Val Gly Phe Pro Glu Gly His 
        915                 920                 925             


Gly Ser Cys Thr Trp Leu Pro Ala Leu Leu Val Gly Ala Asn Thr Phe 
    930                 935                 940                 


Ala Ser His Leu Leu Phe Ala Val Gly Cys Pro Leu Leu Leu Leu Trp 
945                 950                 955                 960 


Pro Phe Leu Cys Glu Ser Gln Gly Leu Arg Lys Arg Gln Gln Pro Pro 
                965                 970                 975     


Gly Asn Glu Ala Asp Ala Arg Val Arg Pro Glu Glu Glu Glu Glu Pro 
            980                 985                 990         


Leu Met Glu Met Arg Leu Arg Asp  Ala Pro Gln His Phe  Tyr Ala Ala 
        995                 1000                 1005             


Leu Leu  Gln Leu Gly Leu Lys  Tyr Leu Phe Ile Leu  Gly Ile Gln 
    1010                 1015                 1020             


Ile Leu  Ala Cys Ala Leu Ala  Ala Ser Ile Leu Arg  Arg His Leu 
    1025                 1030                 1035             


Met Val  Trp Lys Val Phe Ala  Pro Lys Phe Ile Phe  Glu Ala Val 
    1040                 1045                 1050             


Gly Phe  Ile Val Ser Ser Val  Gly Leu Leu Leu Gly  Ile Ala Leu 
    1055                 1060                 1065             


Val Met  Arg Val Asp Gly Ala  Val Ser Ser Trp Phe  Arg Gln Leu 
    1070                 1075                 1080             


Phe Leu  Ala Gln Gln Arg 
    1085                 


<210>  413
<211>  1620
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (95)..(1309)

<400>  413
cagcctcctc acagctcccc atagcctgga cctgccggcc ctccctccag gaccgagggg       60

ctcccaaggg aaactcaggc gtgtgctggt ccca atg tca gtg aaa ccc agc tgg      115
                                      Met Ser Val Lys Pro Ser Trp         
                                      1               5                   

ggg cct ggc ccc tcg gag ggg gtc acc gca gtg cct acc agt gac ctt        163
Gly Pro Gly Pro Ser Glu Gly Val Thr Ala Val Pro Thr Ser Asp Leu           
        10                  15                  20                        

gga gag atc cac aac tgg acc gag ctg ctt gac ctc ttc aac cac act        211
Gly Glu Ile His Asn Trp Thr Glu Leu Leu Asp Leu Phe Asn His Thr           
    25                  30                  35                            

ttg tct gag tgc cac gtg gag ctc agc cag agc acc aag cgc gtg gtc        259
Leu Ser Glu Cys His Val Glu Leu Ser Gln Ser Thr Lys Arg Val Val           
40                  45                  50                  55            

ctc ttt gcc ctc tac ctg gcc atg ttt gtg gtt ggg ctg gtg gag aac        307
Leu Phe Ala Leu Tyr Leu Ala Met Phe Val Val Gly Leu Val Glu Asn           
                60                  65                  70                

ctc ctg gtg ata tgc gtc aac tgg cgc ggc tca ggc cgg gca ggg ctg        355
Leu Leu Val Ile Cys Val Asn Trp Arg Gly Ser Gly Arg Ala Gly Leu           
            75                  80                  85                    

atg aac ctc tac atc ctc aac atg gcc atc gcg gac ctg ggc att gtc        403
Met Asn Leu Tyr Ile Leu Asn Met Ala Ile Ala Asp Leu Gly Ile Val           
        90                  95                  100                       

ctg tct ctg ccc gtg tgg atg ctg gag gtc acg ctg gac tac acc tgg        451
Leu Ser Leu Pro Val Trp Met Leu Glu Val Thr Leu Asp Tyr Thr Trp           
    105                 110                 115                           

ctc tgg ggc agc ttc tcc tgc cgc ttc act cac tac ttc tac ttt gtc        499
Leu Trp Gly Ser Phe Ser Cys Arg Phe Thr His Tyr Phe Tyr Phe Val           
120                 125                 130                 135           

aac atg tat agc agc atc ttc ttc ctg gtg tgc ctc agt gtc gac cgc        547
Asn Met Tyr Ser Ser Ile Phe Phe Leu Val Cys Leu Ser Val Asp Arg           
                140                 145                 150               

tat gtc acc ctc acc agc gcc tcc ccc tcc tgg cag cgt tac cag cac        595
Tyr Val Thr Leu Thr Ser Ala Ser Pro Ser Trp Gln Arg Tyr Gln His           
            155                 160                 165                   

cga gtg cgg cgg gcc atg tgt gca ggc atc tgg gtc ctc tcg gcc atc        643
Arg Val Arg Arg Ala Met Cys Ala Gly Ile Trp Val Leu Ser Ala Ile           
        170                 175                 180                       

atc ccg ctg cct gag gtg gtc cac atc cag ctg gtg gag ggc cct gag        691
Ile Pro Leu Pro Glu Val Val His Ile Gln Leu Val Glu Gly Pro Glu           
    185                 190                 195                           

ccc atg tgc ctc ttc atg gca cct ttt gaa acg tac agc acc tgg gcc        739
Pro Met Cys Leu Phe Met Ala Pro Phe Glu Thr Tyr Ser Thr Trp Ala           
200                 205                 210                 215           

ctg gcg gtg gcc ctg tcc acc acc atc ctg ggc ttc ctg ctg ccc ttc        787
Leu Ala Val Ala Leu Ser Thr Thr Ile Leu Gly Phe Leu Leu Pro Phe           
                220                 225                 230               

cct ctc atc aca gtc ttc aat gtg ctg aca gcc tgc cgg ctg cgg cag        835
Pro Leu Ile Thr Val Phe Asn Val Leu Thr Ala Cys Arg Leu Arg Gln           
            235                 240                 245                   

cca gga caa ccc aag agc cgg cgc cac tgc ctg ctg ctg tgc gcc tac        883
Pro Gly Gln Pro Lys Ser Arg Arg His Cys Leu Leu Leu Cys Ala Tyr           
        250                 255                 260                       

gtg gcc gtc ttt gtc atg tgc tgg ctg ccc tat cat gtg acc ctg ctg        931
Val Ala Val Phe Val Met Cys Trp Leu Pro Tyr His Val Thr Leu Leu           
    265                 270                 275                           

ctg ctc aca ctg cat ggg acc cac atc tcc ctc cac tgc cac ctg gtc        979
Leu Leu Thr Leu His Gly Thr His Ile Ser Leu His Cys His Leu Val           
280                 285                 290                 295           

cac ctg ctc tac ttc ttc tat gat gtc att gac tgc ttc tcc atg ctg       1027
His Leu Leu Tyr Phe Phe Tyr Asp Val Ile Asp Cys Phe Ser Met Leu           
                300                 305                 310               

cac tgt gtc atc aac ccc atc ctt tac aac ttt ctc agc cca cac ttc       1075
His Cys Val Ile Asn Pro Ile Leu Tyr Asn Phe Leu Ser Pro His Phe           
            315                 320                 325                   

cgg ggc cgg ctc ctg aat gct gta gtc cat tac ctt cct aag gac cag       1123
Arg Gly Arg Leu Leu Asn Ala Val Val His Tyr Leu Pro Lys Asp Gln           
        330                 335                 340                       

acc aag gcg ggc aca tgc gcc tcc tct tcc tcc tgt tcc acc cag cat       1171
Thr Lys Ala Gly Thr Cys Ala Ser Ser Ser Ser Cys Ser Thr Gln His           
    345                 350                 355                           

tcc atc atc atc acc aag ggt gat agc cag cct gct gca gca gcc ccc       1219
Ser Ile Ile Ile Thr Lys Gly Asp Ser Gln Pro Ala Ala Ala Ala Pro           
360                 365                 370                 375           

cac cct gag cca agc ctg agc ttt cag gca cac cat ttg ctt cca aat       1267
His Pro Glu Pro Ser Leu Ser Phe Gln Ala His His Leu Leu Pro Asn           
                380                 385                 390               

act tcc ccc atc tct ccc act cag cct ctt aca ccc agc tga               1309
Thr Ser Pro Ile Ser Pro Thr Gln Pro Leu Thr Pro Ser                       
            395                 400                                       

ggtagaggcc agactcctcc aacagtgaag gaaaaggcac aggtgagagt ataggtggga     1369

gatttggggg gatgtagagg ggagggtcaa agcactcgtg gtcaattttg aatctatctt     1429

aaaatactga ggtgtggaga gagagacagg atcaggagcg atagagagca ggccctcagt     1489

gttgtactat ttgtctcggt ccttgtgtct aaggagcaat gcagaaaaaa aggtgaaata     1549

aatggaagag atagccatgg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1609

aaaaaaaaaa a                                                          1620


<210>  414
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  414

Met Ser Val Lys Pro Ser Trp Gly Pro Gly Pro Ser Glu Gly Val Thr 
1               5                   10                  15      


Ala Val Pro Thr Ser Asp Leu Gly Glu Ile His Asn Trp Thr Glu Leu 
            20                  25                  30          


Leu Asp Leu Phe Asn His Thr Leu Ser Glu Cys His Val Glu Leu Ser 
        35                  40                  45              


Gln Ser Thr Lys Arg Val Val Leu Phe Ala Leu Tyr Leu Ala Met Phe 
    50                  55                  60                  


Val Val Gly Leu Val Glu Asn Leu Leu Val Ile Cys Val Asn Trp Arg 
65                  70                  75                  80  


Gly Ser Gly Arg Ala Gly Leu Met Asn Leu Tyr Ile Leu Asn Met Ala 
                85                  90                  95      


Ile Ala Asp Leu Gly Ile Val Leu Ser Leu Pro Val Trp Met Leu Glu 
            100                 105                 110         


Val Thr Leu Asp Tyr Thr Trp Leu Trp Gly Ser Phe Ser Cys Arg Phe 
        115                 120                 125             


Thr His Tyr Phe Tyr Phe Val Asn Met Tyr Ser Ser Ile Phe Phe Leu 
    130                 135                 140                 


Val Cys Leu Ser Val Asp Arg Tyr Val Thr Leu Thr Ser Ala Ser Pro 
145                 150                 155                 160 


Ser Trp Gln Arg Tyr Gln His Arg Val Arg Arg Ala Met Cys Ala Gly 
                165                 170                 175     


Ile Trp Val Leu Ser Ala Ile Ile Pro Leu Pro Glu Val Val His Ile 
            180                 185                 190         


Gln Leu Val Glu Gly Pro Glu Pro Met Cys Leu Phe Met Ala Pro Phe 
        195                 200                 205             


Glu Thr Tyr Ser Thr Trp Ala Leu Ala Val Ala Leu Ser Thr Thr Ile 
    210                 215                 220                 


Leu Gly Phe Leu Leu Pro Phe Pro Leu Ile Thr Val Phe Asn Val Leu 
225                 230                 235                 240 


Thr Ala Cys Arg Leu Arg Gln Pro Gly Gln Pro Lys Ser Arg Arg His 
                245                 250                 255     


Cys Leu Leu Leu Cys Ala Tyr Val Ala Val Phe Val Met Cys Trp Leu 
            260                 265                 270         


Pro Tyr His Val Thr Leu Leu Leu Leu Thr Leu His Gly Thr His Ile 
        275                 280                 285             


Ser Leu His Cys His Leu Val His Leu Leu Tyr Phe Phe Tyr Asp Val 
    290                 295                 300                 


Ile Asp Cys Phe Ser Met Leu His Cys Val Ile Asn Pro Ile Leu Tyr 
305                 310                 315                 320 


Asn Phe Leu Ser Pro His Phe Arg Gly Arg Leu Leu Asn Ala Val Val 
                325                 330                 335     


His Tyr Leu Pro Lys Asp Gln Thr Lys Ala Gly Thr Cys Ala Ser Ser 
            340                 345                 350         


Ser Ser Cys Ser Thr Gln His Ser Ile Ile Ile Thr Lys Gly Asp Ser 
        355                 360                 365             


Gln Pro Ala Ala Ala Ala Pro His Pro Glu Pro Ser Leu Ser Phe Gln 
    370                 375                 380                 


Ala His His Leu Leu Pro Asn Thr Ser Pro Ile Ser Pro Thr Gln Pro 
385                 390                 395                 400 


Leu Thr Pro Ser 
                


<210>  415
<211>  4413
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (218)..(1246)

<400>  415
gtgaaggcgg cgcagcgcgg cgcgggaggc gtgctgggcg cggggctgcg gtgcccagag       60

gctgcggcat taggggctcg gcgcccccga ccttccgcgt cccggggtgg cggcggcggc      120

ggcggcggcg gcgcgggcgg catatgatgc tgagctggct gctccagaat gaaccacagc      180

tctgagaagg ggaagtagaa acagctggcg ccctgcc atg gcc tgt gaa cca cag       235
                                         Met Ala Cys Glu Pro Gln          
                                         1               5                

gtg gac ccg ggg gcc act ggc cca ttg ccc ccc tcc tcc cct ggc tgg        283
Val Asp Pro Gly Ala Thr Gly Pro Leu Pro Pro Ser Ser Pro Gly Trp           
            10                  15                  20                    

agt gcc ctg cct gga ggg agc cct cct ggc tgg ggg caa gag ctc cac        331
Ser Ala Leu Pro Gly Gly Ser Pro Pro Gly Trp Gly Gln Glu Leu His           
        25                  30                  35                        

aat ggc cag gtc ctc act gtt ctc cgg att gac aat acc tgt gca ccc        379
Asn Gly Gln Val Leu Thr Val Leu Arg Ile Asp Asn Thr Cys Ala Pro           
    40                  45                  50                            

atc tcc ttc gac ctg gga gcc gca gaa gag caa ctg caa act tgg ggc        427
Ile Ser Phe Asp Leu Gly Ala Ala Glu Glu Gln Leu Gln Thr Trp Gly           
55                  60                  65                  70            

atc cag gtc ccg gct gac cag tac agg agc ttg gct gag agt gcc ctc        475
Ile Gln Val Pro Ala Asp Gln Tyr Arg Ser Leu Ala Glu Ser Ala Leu           
                75                  80                  85                

ttg gag ccc caa gtg aga aga tat atc atc tac aac tcg agg cct atg        523
Leu Glu Pro Gln Val Arg Arg Tyr Ile Ile Tyr Asn Ser Arg Pro Met           
            90                  95                  100                   

cgg ctg gcc ttt gct gtg gtt ttc tat gtg gtg gtg tgg gcc aat atc        571
Arg Leu Ala Phe Ala Val Val Phe Tyr Val Val Val Trp Ala Asn Ile           
        105                 110                 115                       

tac tct acc agt cag atg ttt gcc ttg ggg aac cac tgg gct ggc atg        619
Tyr Ser Thr Ser Gln Met Phe Ala Leu Gly Asn His Trp Ala Gly Met           
    120                 125                 130                           

ctg ctc gtg acc ctg gcc gcg gtg agc ctg acc ttg act ctt gtg ctg        667
Leu Leu Val Thr Leu Ala Ala Val Ser Leu Thr Leu Thr Leu Val Leu           
135                 140                 145                 150           

gtc ttt gaa aga cac cag aag aag gcc aac acc aac acg gac ctg agg        715
Val Phe Glu Arg His Gln Lys Lys Ala Asn Thr Asn Thr Asp Leu Arg           
                155                 160                 165               

ctg gca gct gcc aat gga gcc ctc ctg aga cac cgg gtg ctg ctg ggg        763
Leu Ala Ala Ala Asn Gly Ala Leu Leu Arg His Arg Val Leu Leu Gly           
            170                 175                 180                   

gtg aca gac aca gtg gaa gga tgc cag agt gtg att cag ctt tgg ttt        811
Val Thr Asp Thr Val Glu Gly Cys Gln Ser Val Ile Gln Leu Trp Phe           
        185                 190                 195                       

gtc tac ttc gac ctg gag aac tgt gtg cag ttt ttg tct gat cat gtt        859
Val Tyr Phe Asp Leu Glu Asn Cys Val Gln Phe Leu Ser Asp His Val           
    200                 205                 210                           

caa gaa atg aag act agc caa gag tcc ttg ctg aga agc aga ttg agc        907
Gln Glu Met Lys Thr Ser Gln Glu Ser Leu Leu Arg Ser Arg Leu Ser           
215                 220                 225                 230           

cag ttg tgt gtt gtc atg gag act ggg gtg agc cct gca aca gcg gag        955
Gln Leu Cys Val Val Met Glu Thr Gly Val Ser Pro Ala Thr Ala Glu           
                235                 240                 245               

ggg cct gag aac ttg gag gat gct cct ctc ctg ccc ggc aat tct tgt       1003
Gly Pro Glu Asn Leu Glu Asp Ala Pro Leu Leu Pro Gly Asn Ser Cys           
            250                 255                 260                   

cct aac gag agg cca ctc atg cag act gag ctt cat cag ctt gtt cct       1051
Pro Asn Glu Arg Pro Leu Met Gln Thr Glu Leu His Gln Leu Val Pro           
        265                 270                 275                       

gag gct gag ccg gag gaa atg gcc cgc cag ctg ctg gca gtg ttt ggc       1099
Glu Ala Glu Pro Glu Glu Met Ala Arg Gln Leu Leu Ala Val Phe Gly           
    280                 285                 290                           

ggc tac tac atc cgg ctt cta gtg acc tcc cag ctc cct cag gca atg       1147
Gly Tyr Tyr Ile Arg Leu Leu Val Thr Ser Gln Leu Pro Gln Ala Met           
295                 300                 305                 310           

ggg aca cga cac acg aac tct ccg aga att cca tgc ccc tgc cag ctc       1195
Gly Thr Arg His Thr Asn Ser Pro Arg Ile Pro Cys Pro Cys Gln Leu           
                315                 320                 325               

ata gaa gcc tac atc cta ggc aca ggg tgc tgc ccg ttc ctg gcg agg       1243
Ile Glu Ala Tyr Ile Leu Gly Thr Gly Cys Cys Pro Phe Leu Ala Arg           
            330                 335                 340                   

tga cctagggatg aaggtactca tcttccttca agactgagca gtcaggaagg            1296

cttcaggagc ccaagatggc caatggggag ccccaggtga ggagagaagc atctgggggc     1356

actccaaaag gggcctgtga tgtcagccac tggggtgttg tgctcacttc agggcccagc     1416

acaaaaatcc ttgtttgaca tctcatgctg accccctggc ctttgcagaa gctgatggtt     1476

acagagctag tcccaccaaa gctactctct ctgctgctta gaactgtgga cacgtatgga     1536

aagactggac ccccattgct ttcattgttc agagaaccca ggagacatga agatgaccag     1596

actgggcaaa ttatgtgtcc aaaacttggc ctcagatgat gtttccatct ccaacccctt     1656

catgccagat ggggaaactg aggctcagag aggatactgc tctatgtggc attgccttga     1716

acccctaaaa ttatcagact tcctttttcc aatataaaga aaaaaagtaa gttttcagaa     1776

ttctctcaat ttttaagttt ttctccccca tattttgtga aaagcagtgg tatgtgtacg     1836

tgttgtctac cagtacacag gctgcagaag acagagacag aagaaagaga tcaagggcag     1896

ataactgttg ataggaatat ttgagaaaga ttgatcctgt ttgacttgag gacttatttt     1956

gttcacaggc atgcacgctt gtggttgtgg ttttatatta cagatgtaga acaatggtta     2016

tgtttcccga catgaacatt gtcctggaat gaagtgtgat cagccacttg tggaattctt     2076

tgaagagctc agaggcttcc aagtgatctg ctcctgaaca agtttgaaga cctattgttt     2136

catagaccca agaccaaacg catctaaagg atccccagcc cccaagacct agcctttgtc     2196

tgcgattttg gcttcatctc ccacaaaacc cctttatgag ttcacgctct ttcctggact     2256

gacataccta ttcctttcca tttgttggac tcctattcat gcttcaaagt ccagctttct     2316

taagcccttc tttaggaagc cttcccacac agccaaccct gctgctctct gcctccttta     2376

aattcttgat acagctgctg cttgttctga tgttttatgg tattgattct gttttcctgt     2436

gtatatgcca gtttttctag ctagactgta aactccttaa ggacagagac tacaccttgt     2496

actttttgtg catgacctgg acctgctaag gaaaaaaaaa tcttgtggat tgattgcttt     2556

gccatcccca cagcagcttt tgcaaattgc tttccaaact cacttgaatg atgacattgc     2616

tgtggacctg ggttctggac ctgatctgcc acttcaagct gtgtaatttt tggcaagttg     2676

ctttctttgc ctggtcctca gtttgcccat caatataatg ggtggattgg atgatttttt     2736

tttttttaat tgagatggag tcttgcactg tcacccaggc tggagtgcag tggcgcgatc     2796

ttggctcact gcaacccccg ccacctaggt tcaagtgatt ctcatgcctc agcctcccaa     2856

gtagctggga ctacaggtgt gcaccactac tcctggatat ttttttgtgt ttttagtaga     2916

gatggggttt cgccatgttg gccaagctgg tcttgaactc ctgacctcag gtgatccacc     2976

cgcctcgggc tcccaaagtg ctgggattac agacgtgagg caccacaacc agcctggatg     3036

attcttaagg gcccttctag gaccaaagtt ctgggaattt ctagcttatt ctgccccctc     3096

atagcccttg gcctatctat ctttatccac atgcagaaac atctggcaac cccacatggc     3156

tgagatgacc tggtcctagg acacccttgg acagaagact ggcctaccta gcagacctgg     3216

atttttcttc ctgatctgct gcttccaagt tgtgtgacct tggctaagtc acttaacctt     3276

tctgattgtc atttcgcttt ttaataaagt gggtctggtg aacaagaaat gtaataaaca     3336

cgtggcttgc cattcaagag atgagtctga ccattcactt tctgtgtgcc agagaagaga     3396

gatcatgggt atagaccagc ccctggaaag gctgctttgg tcaaggctga gagcagcttt     3456

gctcaaggaa attattcacg aaggtgacca ctgtctttct gacctggcac agaggaaatg     3516

ttggctgtga atgtgaccaa tagaaagaag cccgtatttc tcagtcagtc ctagaacccc     3576

ggtaagtaat taacagagaa taaaaatgtg tttgttaaat gacaaagcag cagtttttca     3636

attgtaaggt ctgcttgaga gcctttgatg tgtgtttctt ttcctgactt ttcctttctt     3696

tagaattttt gatggtctca cctggtgggt ggggctttca gggtatgccc acaatgtaca     3756

tttctcggca tctgtgcctc agtttcctca tttataaaat ccctatgatc tctgtctcac     3816

ctactttaca gggttgctgt gaagatcgca tactacacac aggaatgctc atcagttttt     3876

aaattttatt taatttttat ttattttttt ttaaatgtaa ttttttcaga gagataaggt     3936

cttgctatgt tacccagcct agtcttgaac tcctggcctc aagtgatcct cctgccttgg     3996

cctcccatgc tgctgggatt acaggtgtga actaccatgc ccagccagct cctaagtctt     4056

aaggctctgt gttagtgata gatgtggcca tggtgtaggc agtgcaatgt cttcgagtga     4116

gagtgaaggt ggtaactcat tgcatggatt ctagagttct gtttattcta atccaagttc     4176

ttccacttaa aaacaatgtt cttcctctca ttgagtctca ttcctcatct ataggatggg     4236

aataagagca tgtacctggc aggttgttgt aaggattaaa tggtgtaaaa aaatgtcaag     4296

tgcttgcaac tttgaatacc aaacttgagt gaaagctcaa taaattgtta cttaaaaaat     4356

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa        4413


<210>  416
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  416

Met Ala Cys Glu Pro Gln Val Asp Pro Gly Ala Thr Gly Pro Leu Pro 
1               5                   10                  15      


Pro Ser Ser Pro Gly Trp Ser Ala Leu Pro Gly Gly Ser Pro Pro Gly 
            20                  25                  30          


Trp Gly Gln Glu Leu His Asn Gly Gln Val Leu Thr Val Leu Arg Ile 
        35                  40                  45              


Asp Asn Thr Cys Ala Pro Ile Ser Phe Asp Leu Gly Ala Ala Glu Glu 
    50                  55                  60                  


Gln Leu Gln Thr Trp Gly Ile Gln Val Pro Ala Asp Gln Tyr Arg Ser 
65                  70                  75                  80  


Leu Ala Glu Ser Ala Leu Leu Glu Pro Gln Val Arg Arg Tyr Ile Ile 
                85                  90                  95      


Tyr Asn Ser Arg Pro Met Arg Leu Ala Phe Ala Val Val Phe Tyr Val 
            100                 105                 110         


Val Val Trp Ala Asn Ile Tyr Ser Thr Ser Gln Met Phe Ala Leu Gly 
        115                 120                 125             


Asn His Trp Ala Gly Met Leu Leu Val Thr Leu Ala Ala Val Ser Leu 
    130                 135                 140                 


Thr Leu Thr Leu Val Leu Val Phe Glu Arg His Gln Lys Lys Ala Asn 
145                 150                 155                 160 


Thr Asn Thr Asp Leu Arg Leu Ala Ala Ala Asn Gly Ala Leu Leu Arg 
                165                 170                 175     


His Arg Val Leu Leu Gly Val Thr Asp Thr Val Glu Gly Cys Gln Ser 
            180                 185                 190         


Val Ile Gln Leu Trp Phe Val Tyr Phe Asp Leu Glu Asn Cys Val Gln 
        195                 200                 205             


Phe Leu Ser Asp His Val Gln Glu Met Lys Thr Ser Gln Glu Ser Leu 
    210                 215                 220                 


Leu Arg Ser Arg Leu Ser Gln Leu Cys Val Val Met Glu Thr Gly Val 
225                 230                 235                 240 


Ser Pro Ala Thr Ala Glu Gly Pro Glu Asn Leu Glu Asp Ala Pro Leu 
                245                 250                 255     


Leu Pro Gly Asn Ser Cys Pro Asn Glu Arg Pro Leu Met Gln Thr Glu 
            260                 265                 270         


Leu His Gln Leu Val Pro Glu Ala Glu Pro Glu Glu Met Ala Arg Gln 
        275                 280                 285             


Leu Leu Ala Val Phe Gly Gly Tyr Tyr Ile Arg Leu Leu Val Thr Ser 
    290                 295                 300                 


Gln Leu Pro Gln Ala Met Gly Thr Arg His Thr Asn Ser Pro Arg Ile 
305                 310                 315                 320 


Pro Cys Pro Cys Gln Leu Ile Glu Ala Tyr Ile Leu Gly Thr Gly Cys 
                325                 330                 335     


Cys Pro Phe Leu Ala Arg 
            340         


<210>  417
<211>  954
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(954)

<400>  417
atg gca gga aga atg tct acg tct aat cac acc cag ttc cat cct tct         48
Met Ala Gly Arg Met Ser Thr Ser Asn His Thr Gln Phe His Pro Ser           
1               5                   10                  15                

tca ttc cta ctg ctg ggt atc cca ggg cta gaa gat gtg cac att tgg         96
Ser Phe Leu Leu Leu Gly Ile Pro Gly Leu Glu Asp Val His Ile Trp           
            20                  25                  30                    

att gga gtc cct ttt ttc ttt gtg tat ctt gtt gca ctc ctg gga aac        144
Ile Gly Val Pro Phe Phe Phe Val Tyr Leu Val Ala Leu Leu Gly Asn           
        35                  40                  45                        

act gct ctc ttg ttt gtg atc cag act gag cag agt ctc cat gag cct        192
Thr Ala Leu Leu Phe Val Ile Gln Thr Glu Gln Ser Leu His Glu Pro           
    50                  55                  60                            

atg tac tac ttc ctg gcc atg ttg gat tcc att gac ctg ggc ttg tct        240
Met Tyr Tyr Phe Leu Ala Met Leu Asp Ser Ile Asp Leu Gly Leu Ser           
65                  70                  75                  80            

aca gcc acc atc ccc aaa atg ttg ggc atc ttc tgg ttc aat acc aaa        288
Thr Ala Thr Ile Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Thr Lys           
                85                  90                  95                

gaa ata tct ttt gga ggc tgc ctt tct cac atg ttc ttc atc cat ttc        336
Glu Ile Ser Phe Gly Gly Cys Leu Ser His Met Phe Phe Ile His Phe           
            100                 105                 110                   

ttc act gct atg gag agc att gtg ttg gtg gcc atg gcc ttt gac cgc        384
Phe Thr Ala Met Glu Ser Ile Val Leu Val Ala Met Ala Phe Asp Arg           
        115                 120                 125                       

tac att gcc att tgc aaa cct ctt cgg tac acc atg atc ctc acc agc        432
Tyr Ile Ala Ile Cys Lys Pro Leu Arg Tyr Thr Met Ile Leu Thr Ser           
    130                 135                 140                           

aaa atc atc agc ctc att gca ggc att gct gtc ctg agg agc ctg tac        480
Lys Ile Ile Ser Leu Ile Ala Gly Ile Ala Val Leu Arg Ser Leu Tyr           
145                 150                 155                 160           

atg gtt gtt cca ctg gtg ttt ctc ctt ctg agg ctg ccc ttc tgt ggg        528
Met Val Val Pro Leu Val Phe Leu Leu Leu Arg Leu Pro Phe Cys Gly           
                165                 170                 175               

cat cgt atc atc cct cat act tat tgt gag cac atg ggc att gcc cgt        576
His Arg Ile Ile Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg           
            180                 185                 190                   

ctg gcc tgt gcc agc atc aaa gtc aac att agg ttt ggc ctt ggc aac        624
Leu Ala Cys Ala Ser Ile Lys Val Asn Ile Arg Phe Gly Leu Gly Asn           
        195                 200                 205                       

ata tct ctc ttg tta ctg gat gtt atc ctt att att ctc tcc tat gtc        672
Ile Ser Leu Leu Leu Leu Asp Val Ile Leu Ile Ile Leu Ser Tyr Val           
    210                 215                 220                           

agg atc ctg tat gct gtc ttc tgc ctg ccc tcc tgg gaa gct cga ctc        720
Arg Ile Leu Tyr Ala Val Phe Cys Leu Pro Ser Trp Glu Ala Arg Leu           
225                 230                 235                 240           

aaa gct ctc aac acc tgt ggt tct cat att ggt gtt atc tta gcc ttt        768
Lys Ala Leu Asn Thr Cys Gly Ser His Ile Gly Val Ile Leu Ala Phe           
                245                 250                 255               

ttt aca cca gca ttt ttt tca ttc ttg aca cat cgt ttt ggc cat aat        816
Phe Thr Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His Asn           
            260                 265                 270                   

atc cca cag tat ata cat att ata tta gcc aac ctg tat gtg gtt gtc        864
Ile Pro Gln Tyr Ile His Ile Ile Leu Ala Asn Leu Tyr Val Val Val           
        275                 280                 285                       

cca cca gcc ctc aat cct gta atc tat gga gtc agg aca aag cag att        912
Pro Pro Ala Leu Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile           
    290                 295                 300                           

cga gag aga gtg ctg agg att ttt ctc aag acc aat cac taa                954
Arg Glu Arg Val Leu Arg Ile Phe Leu Lys Thr Asn His                       
305                 310                 315                               


<210>  418
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  418

Met Ala Gly Arg Met Ser Thr Ser Asn His Thr Gln Phe His Pro Ser 
1               5                   10                  15      


Ser Phe Leu Leu Leu Gly Ile Pro Gly Leu Glu Asp Val His Ile Trp 
            20                  25                  30          


Ile Gly Val Pro Phe Phe Phe Val Tyr Leu Val Ala Leu Leu Gly Asn 
        35                  40                  45              


Thr Ala Leu Leu Phe Val Ile Gln Thr Glu Gln Ser Leu His Glu Pro 
    50                  55                  60                  


Met Tyr Tyr Phe Leu Ala Met Leu Asp Ser Ile Asp Leu Gly Leu Ser 
65                  70                  75                  80  


Thr Ala Thr Ile Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Thr Lys 
                85                  90                  95      


Glu Ile Ser Phe Gly Gly Cys Leu Ser His Met Phe Phe Ile His Phe 
            100                 105                 110         


Phe Thr Ala Met Glu Ser Ile Val Leu Val Ala Met Ala Phe Asp Arg 
        115                 120                 125             


Tyr Ile Ala Ile Cys Lys Pro Leu Arg Tyr Thr Met Ile Leu Thr Ser 
    130                 135                 140                 


Lys Ile Ile Ser Leu Ile Ala Gly Ile Ala Val Leu Arg Ser Leu Tyr 
145                 150                 155                 160 


Met Val Val Pro Leu Val Phe Leu Leu Leu Arg Leu Pro Phe Cys Gly 
                165                 170                 175     


His Arg Ile Ile Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg 
            180                 185                 190         


Leu Ala Cys Ala Ser Ile Lys Val Asn Ile Arg Phe Gly Leu Gly Asn 
        195                 200                 205             


Ile Ser Leu Leu Leu Leu Asp Val Ile Leu Ile Ile Leu Ser Tyr Val 
    210                 215                 220                 


Arg Ile Leu Tyr Ala Val Phe Cys Leu Pro Ser Trp Glu Ala Arg Leu 
225                 230                 235                 240 


Lys Ala Leu Asn Thr Cys Gly Ser His Ile Gly Val Ile Leu Ala Phe 
                245                 250                 255     


Phe Thr Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His Asn 
            260                 265                 270         


Ile Pro Gln Tyr Ile His Ile Ile Leu Ala Asn Leu Tyr Val Val Val 
        275                 280                 285             


Pro Pro Ala Leu Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile 
    290                 295                 300                 


Arg Glu Arg Val Leu Arg Ile Phe Leu Lys Thr Asn His 
305                 310                 315         


<210>  419
<211>  911
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (327)..(770)

<400>  419
tgggagtcgg ccatcatgct ggccccggag gccgttagct tagtcatggc tctaaatatg       60

tacctgcaat cggatgttga ggatcaccga gcccgcgacg tagaagtacg ggaagttcat      120

gcgcagctgc caggccagct cgaagaaggc gagcagggtg cgggagagcc ccttgcagaa      180

gacgccgtac gaggttctcc agcatttggc tcaaggcccc aagggcacat gtgacaagaa      240

ggcgccagct ttttaaacat tggaagttct tctgtgtcag ttctgtgaca gaacatttac      300

ttaacacatc atgaaggcta gtttgg atg tgg agg gga ata gac tcc atc tat       353
                             Met Trp Arg Gly Ile Asp Ser Ile Tyr          
                             1               5                            

cca tat gag ctg ctg cag aag aat att ttg cct gct gga acc tgc tgt        401
Pro Tyr Glu Leu Leu Gln Lys Asn Ile Leu Pro Ala Gly Thr Cys Cys           
10                  15                  20                  25            

atc tac tca aga gtg gaa gtt ttc aca gat gtg aac tat gaa gac ttt        449
Ile Tyr Ser Arg Val Glu Val Phe Thr Asp Val Asn Tyr Glu Asp Phe           
                30                  35                  40                

act ttc acc ata cca gat gta gag gac tca agt cag aga cca gat cag        497
Thr Phe Thr Ile Pro Asp Val Glu Asp Ser Ser Gln Arg Pro Asp Gln           
            45                  50                  55                    

gga ccc cag aga cct cct cct gaa gga ctc cta cct aga ccc cct ggt        545
Gly Pro Gln Arg Pro Pro Pro Glu Gly Leu Leu Pro Arg Pro Pro Gly           
        60                  65                  70                        

gat agt ggt aac caa gat gat ggt cct cag cag aga cca cca aaa cca        593
Asp Ser Gly Asn Gln Asp Asp Gly Pro Gln Gln Arg Pro Pro Lys Pro           
    75                  80                  85                            

gga ggc cat cac cgc cat cct ccc cca cct cct ttt caa aat cag caa        641
Gly Gly His His Arg His Pro Pro Pro Pro Pro Phe Gln Asn Gln Gln           
90                  95                  100                 105           

cga cca ccc cga cga gga cac cgt caa ctc tct cta ccc cga ttt cct        689
Arg Pro Pro Arg Arg Gly His Arg Gln Leu Ser Leu Pro Arg Phe Pro           
                110                 115                 120               

tct gtc agc ctg cag gaa gca tca tca ttc ttc cag agg gac aga cca        737
Ser Val Ser Leu Gln Glu Ala Ser Ser Phe Phe Gln Arg Asp Arg Pro           
            125                 130                 135                   

gca aga cat ccc cag gag caa cca ctc tgg taa tctagaattc agtggcagaa      790
Ala Arg His Pro Gln Glu Gln Pro Leu Trp                                   
        140                 145                                           

aataaataag aagataactt ccttcagaaa gccatgacat tgaaataatg tggtcataac      850

tctttcttca gtataccaat aaaatattaa tagcatgcaa aaaaaaaaaa aaaaaaaaaa      910

a                                                                      911


<210>  420
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  420

Met Trp Arg Gly Ile Asp Ser Ile Tyr Pro Tyr Glu Leu Leu Gln Lys 
1               5                   10                  15      


Asn Ile Leu Pro Ala Gly Thr Cys Cys Ile Tyr Ser Arg Val Glu Val 
            20                  25                  30          


Phe Thr Asp Val Asn Tyr Glu Asp Phe Thr Phe Thr Ile Pro Asp Val 
        35                  40                  45              


Glu Asp Ser Ser Gln Arg Pro Asp Gln Gly Pro Gln Arg Pro Pro Pro 
    50                  55                  60                  


Glu Gly Leu Leu Pro Arg Pro Pro Gly Asp Ser Gly Asn Gln Asp Asp 
65                  70                  75                  80  


Gly Pro Gln Gln Arg Pro Pro Lys Pro Gly Gly His His Arg His Pro 
                85                  90                  95      


Pro Pro Pro Pro Phe Gln Asn Gln Gln Arg Pro Pro Arg Arg Gly His 
            100                 105                 110         


Arg Gln Leu Ser Leu Pro Arg Phe Pro Ser Val Ser Leu Gln Glu Ala 
        115                 120                 125             


Ser Ser Phe Phe Gln Arg Asp Arg Pro Ala Arg His Pro Gln Glu Gln 
    130                 135                 140                 


Pro Leu Trp 
145         


<210>  421
<211>  585
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(585)

<400>  421
atg ctc tcc tcc aca ctc agg gtg gct gtg gtg tgc gtg agc aat gtc         48
Met Leu Ser Ser Thr Leu Arg Val Ala Val Val Cys Val Ser Asn Val           
1               5                   10                  15                

aac agg agc atg gag gcc cac agc atc ctc agg aaa aaa ggg cta agt         96
Asn Arg Ser Met Glu Ala His Ser Ile Leu Arg Lys Lys Gly Leu Ser           
            20                  25                  30                    

gtc cgg tct ttt gga act gaa tct cat gtg agg cta cca gga cca aga        144
Val Arg Ser Phe Gly Thr Glu Ser His Val Arg Leu Pro Gly Pro Arg           
        35                  40                  45                        

ccc aat cgt cct gta gtt tat gat ttt gca aca aca tat aag gag atg        192
Pro Asn Arg Pro Val Val Tyr Asp Phe Ala Thr Thr Tyr Lys Glu Met           
    50                  55                  60                            

tac aat gac ctc ctc agg aaa gat aga gaa tgc tac acc cgc aac gga        240
Tyr Asn Asp Leu Leu Arg Lys Asp Arg Glu Cys Tyr Thr Arg Asn Gly           
65                  70                  75                  80            

atc tta cac atc ttg gga aga aat gag aga atc aag ccc ggt cca gaa        288
Ile Leu His Ile Leu Gly Arg Asn Glu Arg Ile Lys Pro Gly Pro Glu           
                85                  90                  95                

aga ttt cag gag tgc act gat ttc ttt gat gtc atc ttc acc tgt gag        336
Arg Phe Gln Glu Cys Thr Asp Phe Phe Asp Val Ile Phe Thr Cys Glu           
            100                 105                 110                   

gag agt gtc tat gac aca gtg gtg gaa gat ctg tgt tcc aga gaa cag        384
Glu Ser Val Tyr Asp Thr Val Val Glu Asp Leu Cys Ser Arg Glu Gln           
        115                 120                 125                       

cag acc ttt cag cct gtg cac gtg atc aac atg gaa atc caa gat acc        432
Gln Thr Phe Gln Pro Val His Val Ile Asn Met Glu Ile Gln Asp Thr           
    130                 135                 140                           

ctg gaa gat gcc acc ctg gga gct ttc ctc atc tgt gag att tgc cag        480
Leu Glu Asp Ala Thr Leu Gly Ala Phe Leu Ile Cys Glu Ile Cys Gln           
145                 150                 155                 160           

tgc ctg cag cag tca gac gac atg gaa gac aat ctg gag gag ctg ctc        528
Cys Leu Gln Gln Ser Asp Asp Met Glu Asp Asn Leu Glu Glu Leu Leu           
                165                 170                 175               

ttg caa atg gag gag aag gca gga aaa agc ttt ctt cac acc gtc tgc        576
Leu Gln Met Glu Glu Lys Ala Gly Lys Ser Phe Leu His Thr Val Cys           
            180                 185                 190                   

ttc tac tga                                                            585
Phe Tyr                                                                   
                                                                          


<210>  422
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  422

Met Leu Ser Ser Thr Leu Arg Val Ala Val Val Cys Val Ser Asn Val 
1               5                   10                  15      


Asn Arg Ser Met Glu Ala His Ser Ile Leu Arg Lys Lys Gly Leu Ser 
            20                  25                  30          


Val Arg Ser Phe Gly Thr Glu Ser His Val Arg Leu Pro Gly Pro Arg 
        35                  40                  45              


Pro Asn Arg Pro Val Val Tyr Asp Phe Ala Thr Thr Tyr Lys Glu Met 
    50                  55                  60                  


Tyr Asn Asp Leu Leu Arg Lys Asp Arg Glu Cys Tyr Thr Arg Asn Gly 
65                  70                  75                  80  


Ile Leu His Ile Leu Gly Arg Asn Glu Arg Ile Lys Pro Gly Pro Glu 
                85                  90                  95      


Arg Phe Gln Glu Cys Thr Asp Phe Phe Asp Val Ile Phe Thr Cys Glu 
            100                 105                 110         


Glu Ser Val Tyr Asp Thr Val Val Glu Asp Leu Cys Ser Arg Glu Gln 
        115                 120                 125             


Gln Thr Phe Gln Pro Val His Val Ile Asn Met Glu Ile Gln Asp Thr 
    130                 135                 140                 


Leu Glu Asp Ala Thr Leu Gly Ala Phe Leu Ile Cys Glu Ile Cys Gln 
145                 150                 155                 160 


Cys Leu Gln Gln Ser Asp Asp Met Glu Asp Asn Leu Glu Glu Leu Leu 
                165                 170                 175     


Leu Gln Met Glu Glu Lys Ala Gly Lys Ser Phe Leu His Thr Val Cys 
            180                 185                 190         


Phe Tyr 
        


<210>  423
<211>  599
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (237)..(443)

<400>  423
cccggcagtg cacacacacg gcaggggcgg gcgacagatg cagtgcgtgc gccggagccc       60

aagcgcacaa acggaaagag cgggcgcggt gcgcaggggc gggcgcccag cgggcttggc      120

atgcgcgccc ccgcccgagg ctataaaagc atcgccacct gctgccacta gccaagccgc      180

gcgtccagtt gcttggagaa gcccgttcac cgcctccagc tgctgctctc ctcgac atg      239
                                                              Met         
                                                              1           

gac cct gag acc tgc ccc tgc cct tct ggt ggc tcc tgc acc tgc gcg        287
Asp Pro Glu Thr Cys Pro Cys Pro Ser Gly Gly Ser Cys Thr Cys Ala           
            5                   10                  15                    

gac tcc tgc aag tgc gag gga tgc aaa tgc acc tcc tgc aag aag agc        335
Asp Ser Cys Lys Cys Glu Gly Cys Lys Cys Thr Ser Cys Lys Lys Ser           
        20                  25                  30                        

tgc tgc tcc tgc tgc cct gcg gag tgt gag aag tgt gcc aag gac tgt        383
Cys Cys Ser Cys Cys Pro Ala Glu Cys Glu Lys Cys Ala Lys Asp Cys           
    35                  40                  45                            

gtg tgc aaa ggc gga gag gca gct gag gca gaa gca gag aag tgc agc        431
Val Cys Lys Gly Gly Glu Ala Ala Glu Ala Glu Ala Glu Lys Cys Ser           
50                  55                  60                  65            

tgc tgc cag tga gaaggcaccc ctccgtgtgg agcacgtgga gatagtgcca            483
Cys Cys Gln                                                               
                                                                          

ggtggctcag tgccacctat gcctgtggtg aagtgtggct ggtgtcccct tcccctgctg      543

accttggagg aatgacaata aatcccatga acagcatgaa aaaaaaaaaa aaaaaa          599


<210>  424
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  424

Met Asp Pro Glu Thr Cys Pro Cys Pro Ser Gly Gly Ser Cys Thr Cys 
1               5                   10                  15      


Ala Asp Ser Cys Lys Cys Glu Gly Cys Lys Cys Thr Ser Cys Lys Lys 
            20                  25                  30          


Ser Cys Cys Ser Cys Cys Pro Ala Glu Cys Glu Lys Cys Ala Lys Asp 
        35                  40                  45              


Cys Val Cys Lys Gly Gly Glu Ala Ala Glu Ala Glu Ala Glu Lys Cys 
    50                  55                  60                  


Ser Cys Cys Gln 
65              


<210>  425
<211>  3487
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (43)..(1530)

<400>  425
ttgctccaca gtcgcgtgct agactccgga cccgccagtg gt atg gct gag ccg          54
                                               Met Ala Glu Pro            
                                               1                          

act agt gat ttc gag act cct atc ggg tgg cat gcg tct ccc gag ctg        102
Thr Ser Asp Phe Glu Thr Pro Ile Gly Trp His Ala Ser Pro Glu Leu           
5                   10                  15                  20            

act ccc acg tta ggg ccc ctg agc gac act gcc ccg ccg cgg gac agc        150
Thr Pro Thr Leu Gly Pro Leu Ser Asp Thr Ala Pro Pro Arg Asp Ser           
                25                  30                  35                

tgg atg ttc tgg gca atg ctg ccg cca ccg cca cca cca ctt acg tcc        198
Trp Met Phe Trp Ala Met Leu Pro Pro Pro Pro Pro Pro Leu Thr Ser           
            40                  45                  50                    

tcg ctt ccc gca gcc ggg tca aag cct tcc tct gag tcg cag ccc ccc        246
Ser Leu Pro Ala Ala Gly Ser Lys Pro Ser Ser Glu Ser Gln Pro Pro           
        55                  60                  65                        

atg gag gcc cag tct ctc ccc ggg gct ccg ccc ccc ttc gac gcc cag        294
Met Glu Ala Gln Ser Leu Pro Gly Ala Pro Pro Pro Phe Asp Ala Gln           
    70                  75                  80                            

att ctt ccc ggg gcg caa ccc ccc ttc gac gcc cag tct ccc ctt gat        342
Ile Leu Pro Gly Ala Gln Pro Pro Phe Asp Ala Gln Ser Pro Leu Asp           
85                  90                  95                  100           

tct cag cct caa ccc agc ggc cag cct tgg aat ttc cat gct tcc aca        390
Ser Gln Pro Gln Pro Ser Gly Gln Pro Trp Asn Phe His Ala Ser Thr           
                105                 110                 115               

tcg tgg tat tgg aga cag tct tct gat agg ttt cct cgg cat cag aag        438
Ser Trp Tyr Trp Arg Gln Ser Ser Asp Arg Phe Pro Arg His Gln Lys           
            120                 125                 130                   

tcc ttc aac cct gca gtt aaa aat tct tat tat cca cga aag tat gat        486
Ser Phe Asn Pro Ala Val Lys Asn Ser Tyr Tyr Pro Arg Lys Tyr Asp           
        135                 140                 145                       

gca aaa ttc aca gac ttc agc tta cct ccc agt aga aaa cag aaa aaa        534
Ala Lys Phe Thr Asp Phe Ser Leu Pro Pro Ser Arg Lys Gln Lys Lys           
    150                 155                 160                           

aag aaa aga aag gaa cca gtt ttt cac ttt ttt tgt gat acc tgt gat        582
Lys Lys Arg Lys Glu Pro Val Phe His Phe Phe Cys Asp Thr Cys Asp           
165                 170                 175                 180           

cgt ggt ttt aaa aat caa gaa aag tat gac aaa cac atg tct gaa cat        630
Arg Gly Phe Lys Asn Gln Glu Lys Tyr Asp Lys His Met Ser Glu His           
                185                 190                 195               

aca aaa tgc cct gaa tta gat tgc tct ttt act gca cac gag aag att        678
Thr Lys Cys Pro Glu Leu Asp Cys Ser Phe Thr Ala His Glu Lys Ile           
            200                 205                 210                   

gtc cag ttc cat tgg aga aat atg cat gct cct ggc atg aag aag atc        726
Val Gln Phe His Trp Arg Asn Met His Ala Pro Gly Met Lys Lys Ile           
        215                 220                 225                       

aag tta gac act cca gag gaa att gca cgg tgg agg gaa gaa aga agg        774
Lys Leu Asp Thr Pro Glu Glu Ile Ala Arg Trp Arg Glu Glu Arg Arg           
    230                 235                 240                           

aaa aac tat cca act ctg gcc aat att gaa agg aag aag aag tta aaa        822
Lys Asn Tyr Pro Thr Leu Ala Asn Ile Glu Arg Lys Lys Lys Leu Lys           
245                 250                 255                 260           

ctt gaa aag gag aag aga gga gca gta ttg aca aca aca caa tat ggc        870
Leu Glu Lys Glu Lys Arg Gly Ala Val Leu Thr Thr Thr Gln Tyr Gly           
                265                 270                 275               

aag atg aag ggg atg tcc aga cat tca caa atg gca aag atc aga agt        918
Lys Met Lys Gly Met Ser Arg His Ser Gln Met Ala Lys Ile Arg Ser           
            280                 285                 290                   

cct ggc aag aat cac aaa tgg aaa aac gac aat tct aga cag aga gca        966
Pro Gly Lys Asn His Lys Trp Lys Asn Asp Asn Ser Arg Gln Arg Ala           
        295                 300                 305                       

gtc act gga tca ggc agt cac ttg tgt gat ttg aag cta gaa ggt cca       1014
Val Thr Gly Ser Gly Ser His Leu Cys Asp Leu Lys Leu Glu Gly Pro           
    310                 315                 320                           

ccg gag gca aat gca gat cct ctt ggt gtt ttg ata aac agt gat tct       1062
Pro Glu Ala Asn Ala Asp Pro Leu Gly Val Leu Ile Asn Ser Asp Ser           
325                 330                 335                 340           

gag tct gat aag gag gag aaa cca caa cat tct gtg ata ccc aag gaa       1110
Glu Ser Asp Lys Glu Glu Lys Pro Gln His Ser Val Ile Pro Lys Glu           
                345                 350                 355               

gtg aca cca gcc cta tgc tca cta atg agt agc tat ggc agt ctt tca       1158
Val Thr Pro Ala Leu Cys Ser Leu Met Ser Ser Tyr Gly Ser Leu Ser           
            360                 365                 370                   

ggg tca gag agt gag cca gaa gaa act ccc atc aag act gaa gca gac       1206
Gly Ser Glu Ser Glu Pro Glu Glu Thr Pro Ile Lys Thr Glu Ala Asp           
        375                 380                 385                       

gtt ttg gca gaa aac cag gtt ctt gat agc agt gct cct aag agt cca       1254
Val Leu Ala Glu Asn Gln Val Leu Asp Ser Ser Ala Pro Lys Ser Pro           
    390                 395                 400                           

agt caa gat gtt aaa gca act gtt aga aat ttt tca gaa gcc aag agt       1302
Ser Gln Asp Val Lys Ala Thr Val Arg Asn Phe Ser Glu Ala Lys Ser           
405                 410                 415                 420           

gag aac cga aag aaa agc ttt gaa aaa aca aac cct aag agg aaa aaa       1350
Glu Asn Arg Lys Lys Ser Phe Glu Lys Thr Asn Pro Lys Arg Lys Lys           
                425                 430                 435               

gat tat cac aac tat caa acg tta ttc gaa cca aga aca cac cat cca       1398
Asp Tyr His Asn Tyr Gln Thr Leu Phe Glu Pro Arg Thr His His Pro           
            440                 445                 450                   

tat ctc ttg gaa atg ctt cta gct ccg gac att cga cat gaa aga aat       1446
Tyr Leu Leu Glu Met Leu Leu Ala Pro Asp Ile Arg His Glu Arg Asn           
        455                 460                 465                       

gtg att ttg cag tgt gtt cgg tac atc atc aaa aaa gac ttt ttt gga       1494
Val Ile Leu Gln Cys Val Arg Tyr Ile Ile Lys Lys Asp Phe Phe Gly           
    470                 475                 480                           

ctg gat act aat tct gcg aaa agt aaa gat gta tag gcatctggtg            1540
Leu Asp Thr Asn Ser Ala Lys Ser Lys Asp Val                               
485                 490                 495                               

tttcagcata cataactgaa gcatgtgaaa cagtatcatc ctcgttagta gaggaaaacc     1600

aaaacccttt tttccgtcaa aattggattt gtaattaaat tgtaagcctc gtaggatgta     1660

tgttggaatt ttaagtcttt cctttggttc tatgcaaata aaaaaataac tgatttttta     1720

agactgtgtc tgtattgttg ggattgaatc tagtatttgc tgggagaatt ttttctttgt     1780

atttatttta atgtattgtt ctcatgtaag aatgactgat gttgtgttag ttaagaattg     1840

aagataggtt tagcagtaaa gaagaaagct tttaaaagga ttgattcagc taagcaaagt     1900

tgggcagaga aatacagcca ttttgttttt aatgcagaaa aggaagatgt tctgtagcaa     1960

gggggaatat tttaaaaata aaccagatca aattaataca atcagaaggt ttcgaaatgt     2020

aaatattcct tatttaagac atgtttaaat tcacctacta gcacgactta catagctcaa     2080

atattgaatg tttaaaatat taatacagat ggggcctctt tatgtttaga taaaattgaa     2140

gtacttaatt gaagcttttt aaaaattgta aagtaaatga aagctattga gatctttttg     2200

tctcctataa taccagggaa tttgagcttg tgttctagtc attgtactag ctgtagctat     2260

tggtctgtcc ttttgacata cagctaaaag ggactaaatt tgtaaaaaat tagtttgtta     2320

tagttgaaga ttaacttttc ctaacattgt gattattgaa gttcatgaat cttgctgtca     2380

aggaagaaag gtaagaaagc tgatagctcc tccatgttgg taaaatcctc tccagaatct     2440

tggaacacct ggcatgtgac cctagtgacg tcacagacct gagatgaaga ttcatgttta     2500

gccagtgttt tccagccttg tacccaccat acagatctgt ttattctgtt tcaccctact     2560

cctccagtga gccccatatt ttgggaaatt atctgcctta tacattaact aattcaattc     2620

atgtaacact gttgagtgct tactctttgt acctctattg tgcctatatt aaaggtatac     2680

aaataaataa ggccatgtct gacttcaagg aactcagttt aattttgata tattcaaaga     2740

tgtgattccc aaccaactca ggatgaagta actagtgtta caactgagtt gatattctaa     2800

aatataacac agtttgtact tttattacta gttagcatac acattttata ggcttatggg     2860

ttaataaatg aattcatgga ctcctggact actttcattg atgaccatat ctccagggat     2920

gttgttgatc cccacactgc cttaaggtat attatagaaa cagttttatt ttccattttt     2980

cttgtttcct gataataaat gtatttagga ctgaaaatac tcctgagtac tcccttggct     3040

gtatgtctga cagtctttag ctatggtgac tattgtttat ttttaatggg tatttcagat     3100

tccaagtgta tttaaaattt ctaaggagat ataatatagc ctgtatggtt tctactttat     3160

ggaattatat ggtcaatatt tgtaaatatt ctatgagttt tgggtgggta gaggggtgct     3220

ttgcctgttt tgggtacagg tttttttgga tttagcttgt taattgttca aactttctgc     3280

cttctacatt cctatcttat tgttcgttta atcagtttct gaaatgtaag cattacatga     3340

ctattggtga gttgtgcctt ttataactga aatactttac tttttctcat atcctctata     3400

attgacttct attttcctta atcaaaccag ctctgggaaa tttaatacat ttatattaat     3460

tgagattatt aaaacatttg gactatt                                         3487


<210>  426
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  426

Met Ala Glu Pro Thr Ser Asp Phe Glu Thr Pro Ile Gly Trp His Ala 
1               5                   10                  15      


Ser Pro Glu Leu Thr Pro Thr Leu Gly Pro Leu Ser Asp Thr Ala Pro 
            20                  25                  30          


Pro Arg Asp Ser Trp Met Phe Trp Ala Met Leu Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Leu Thr Ser Ser Leu Pro Ala Ala Gly Ser Lys Pro Ser Ser Glu 
    50                  55                  60                  


Ser Gln Pro Pro Met Glu Ala Gln Ser Leu Pro Gly Ala Pro Pro Pro 
65                  70                  75                  80  


Phe Asp Ala Gln Ile Leu Pro Gly Ala Gln Pro Pro Phe Asp Ala Gln 
                85                  90                  95      


Ser Pro Leu Asp Ser Gln Pro Gln Pro Ser Gly Gln Pro Trp Asn Phe 
            100                 105                 110         


His Ala Ser Thr Ser Trp Tyr Trp Arg Gln Ser Ser Asp Arg Phe Pro 
        115                 120                 125             


Arg His Gln Lys Ser Phe Asn Pro Ala Val Lys Asn Ser Tyr Tyr Pro 
    130                 135                 140                 


Arg Lys Tyr Asp Ala Lys Phe Thr Asp Phe Ser Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Lys Gln Lys Lys Lys Lys Arg Lys Glu Pro Val Phe His Phe Phe Cys 
                165                 170                 175     


Asp Thr Cys Asp Arg Gly Phe Lys Asn Gln Glu Lys Tyr Asp Lys His 
            180                 185                 190         


Met Ser Glu His Thr Lys Cys Pro Glu Leu Asp Cys Ser Phe Thr Ala 
        195                 200                 205             


His Glu Lys Ile Val Gln Phe His Trp Arg Asn Met His Ala Pro Gly 
    210                 215                 220                 


Met Lys Lys Ile Lys Leu Asp Thr Pro Glu Glu Ile Ala Arg Trp Arg 
225                 230                 235                 240 


Glu Glu Arg Arg Lys Asn Tyr Pro Thr Leu Ala Asn Ile Glu Arg Lys 
                245                 250                 255     


Lys Lys Leu Lys Leu Glu Lys Glu Lys Arg Gly Ala Val Leu Thr Thr 
            260                 265                 270         


Thr Gln Tyr Gly Lys Met Lys Gly Met Ser Arg His Ser Gln Met Ala 
        275                 280                 285             


Lys Ile Arg Ser Pro Gly Lys Asn His Lys Trp Lys Asn Asp Asn Ser 
    290                 295                 300                 


Arg Gln Arg Ala Val Thr Gly Ser Gly Ser His Leu Cys Asp Leu Lys 
305                 310                 315                 320 


Leu Glu Gly Pro Pro Glu Ala Asn Ala Asp Pro Leu Gly Val Leu Ile 
                325                 330                 335     


Asn Ser Asp Ser Glu Ser Asp Lys Glu Glu Lys Pro Gln His Ser Val 
            340                 345                 350         


Ile Pro Lys Glu Val Thr Pro Ala Leu Cys Ser Leu Met Ser Ser Tyr 
        355                 360                 365             


Gly Ser Leu Ser Gly Ser Glu Ser Glu Pro Glu Glu Thr Pro Ile Lys 
    370                 375                 380                 


Thr Glu Ala Asp Val Leu Ala Glu Asn Gln Val Leu Asp Ser Ser Ala 
385                 390                 395                 400 


Pro Lys Ser Pro Ser Gln Asp Val Lys Ala Thr Val Arg Asn Phe Ser 
                405                 410                 415     


Glu Ala Lys Ser Glu Asn Arg Lys Lys Ser Phe Glu Lys Thr Asn Pro 
            420                 425                 430         


Lys Arg Lys Lys Asp Tyr His Asn Tyr Gln Thr Leu Phe Glu Pro Arg 
        435                 440                 445             


Thr His His Pro Tyr Leu Leu Glu Met Leu Leu Ala Pro Asp Ile Arg 
    450                 455                 460                 


His Glu Arg Asn Val Ile Leu Gln Cys Val Arg Tyr Ile Ile Lys Lys 
465                 470                 475                 480 


Asp Phe Phe Gly Leu Asp Thr Asn Ser Ala Lys Ser Lys Asp Val 
                485                 490                 495 


<210>  427
<211>  2320
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (265)..(1929)

<400>  427
gtgagcgcct gagagtcttt ttgcctttca gagttaaggc ctcactggcc tgggaaaata       60

attgctgcct tttgcatccg cgttggctcc gtccccagga tcttcccggt tcagggacct      120

ggcgatttct gagtgttccg gaatcccaat aaccctgttt aaagaggaat ggagattgcc      180

actgtccatt tagattaatg aggtgtcctg aagtgatggt gacatcaatg aaaggagggt      240

tctgacacgt tctcacctcg cggg atg gca gct gct gat ttg tcc cat gga         291
                           Met Ala Ala Ala Asp Leu Ser His Gly            
                           1               5                              

cat tat ctt tct ggg gac cca gtt tgc ctt cat gaa gaa aag aca cca        339
His Tyr Leu Ser Gly Asp Pro Val Cys Leu His Glu Glu Lys Thr Pro           
10                  15                  20                  25            

gca gga aga ata gtg gct gac tgc cta aca gat tgt tat cag gat tca        387
Ala Gly Arg Ile Val Ala Asp Cys Leu Thr Asp Cys Tyr Gln Asp Ser           
                30                  35                  40                

gtg acc ttt gac gat gtg gct gtg gac ttc acc cag gag gag tgg act        435
Val Thr Phe Asp Asp Val Ala Val Asp Phe Thr Gln Glu Glu Trp Thr           
            45                  50                  55                    

tta ctg gac tca act cag aga agc ctc tac agt gac gtg atg ctg gag        483
Leu Leu Asp Ser Thr Gln Arg Ser Leu Tyr Ser Asp Val Met Leu Glu           
        60                  65                  70                        

aac tac aag aac ctg gcc aca gta gga ggt cag atc atc aaa ccc agt        531
Asn Tyr Lys Asn Leu Ala Thr Val Gly Gly Gln Ile Ile Lys Pro Ser           
    75                  80                  85                            

cta atc tct tgg ttg gaa caa gaa gag tca agg aca gtt cag gga gga        579
Leu Ile Ser Trp Leu Glu Gln Glu Glu Ser Arg Thr Val Gln Gly Gly           
90                  95                  100                 105           

gtt ctc caa gga tgg gaa atg cga ctt gaa acc cag tgg tct ata ctt        627
Val Leu Gln Gly Trp Glu Met Arg Leu Glu Thr Gln Trp Ser Ile Leu           
                110                 115                 120               

cag cag gac ttt ttg agg ggt cag aca tcc att ggg ata caa ttg gaa        675
Gln Gln Asp Phe Leu Arg Gly Gln Thr Ser Ile Gly Ile Gln Leu Glu           
            125                 130                 135                   

gga aaa cac aat gga agg gaa ctc tgt gac tgt gag caa tgt gga gaa        723
Gly Lys His Asn Gly Arg Glu Leu Cys Asp Cys Glu Gln Cys Gly Glu           
        140                 145                 150                       

gtc ttc agt gaa cac tca tgc ctt aag acg cac gtg aga act caa agt        771
Val Phe Ser Glu His Ser Cys Leu Lys Thr His Val Arg Thr Gln Ser           
    155                 160                 165                           

aca ggg aac act cat gac tgt aat cag tat gga aaa gat ttc ctt acc        819
Thr Gly Asn Thr His Asp Cys Asn Gln Tyr Gly Lys Asp Phe Leu Thr           
170                 175                 180                 185           

ctg tgt gag aaa acc tct act ggt gag aaa ctt tct gag ttt aat cag        867
Leu Cys Glu Lys Thr Ser Thr Gly Glu Lys Leu Ser Glu Phe Asn Gln           
                190                 195                 200               

agt gaa aaa atc ttc agc ctg aca cca aat att gta tac cag aga act        915
Ser Glu Lys Ile Phe Ser Leu Thr Pro Asn Ile Val Tyr Gln Arg Thr           
            205                 210                 215                   

agc aca caa gaa aag tca ttt gaa tgt agt cac tgt gga aaa tcc ttc        963
Ser Thr Gln Glu Lys Ser Phe Glu Cys Ser His Cys Gly Lys Ser Phe           
        220                 225                 230                       

att aat gag tca tac ctt cag gca cat atg aga act cac aat gga gaa       1011
Ile Asn Glu Ser Tyr Leu Gln Ala His Met Arg Thr His Asn Gly Glu           
    235                 240                 245                           

aaa ctc tac gaa tgg agg aat tat ggg cca ggt ttt att gac tct aca       1059
Lys Leu Tyr Glu Trp Arg Asn Tyr Gly Pro Gly Phe Ile Asp Ser Thr           
250                 255                 260                 265           

agc ctt tct gtg ctt ata gaa acc ctc aat gca aaa aag ccc tac aaa       1107
Ser Leu Ser Val Leu Ile Glu Thr Leu Asn Ala Lys Lys Pro Tyr Lys           
                270                 275                 280               

tgt aag gaa tgt gga aaa ggc tat aga tac cca gcc tac ctc agt att       1155
Cys Lys Glu Cys Gly Lys Gly Tyr Arg Tyr Pro Ala Tyr Leu Ser Ile           
            285                 290                 295                   

cac atg cga acc cac act ggg gag aaa cca tat gaa tgt aag gaa tgt       1203
His Met Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys           
        300                 305                 310                       

ggg aaa gcc ttc aat tat tcc aac tca ttt cag ata cat gga aga act       1251
Gly Lys Ala Phe Asn Tyr Ser Asn Ser Phe Gln Ile His Gly Arg Thr           
    315                 320                 325                           

cac act gga gag aaa ccc tat gta tgt aag gaa tgt ggg aaa gcc ttc       1299
His Thr Gly Glu Lys Pro Tyr Val Cys Lys Glu Cys Gly Lys Ala Phe           
330                 335                 340                 345           

act cag tac tcg ggc ctt agt atg cat gta cga tct cac agt gga gac       1347
Thr Gln Tyr Ser Gly Leu Ser Met His Val Arg Ser His Ser Gly Asp           
                350                 355                 360               

aag ccc tat gaa tgt aag gaa tgt ggg aaa tcc ttc ctt aca tcc tca       1395
Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ser Phe Leu Thr Ser Ser           
            365                 370                 375                   

cgc ctt att caa cat ata aga act cac act gga gag aag cct ttt gta       1443
Arg Leu Ile Gln His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Val           
        380                 385                 390                       

tgt gtt gaa tgt ggg aaa gcc ttt gca gtt tcc tca aat ctt agt gga       1491
Cys Val Glu Cys Gly Lys Ala Phe Ala Val Ser Ser Asn Leu Ser Gly           
    395                 400                 405                           

cat ttg aga act cac act gaa gag aag gcc tgt gag tgt aag ata tgt       1539
His Leu Arg Thr His Thr Glu Glu Lys Ala Cys Glu Cys Lys Ile Cys           
410                 415                 420                 425           

ggg aaa gta ttt ggg tat ccc tca tgt ctt aat aat cac atg cga acg       1587
Gly Lys Val Phe Gly Tyr Pro Ser Cys Leu Asn Asn His Met Arg Thr           
                430                 435                 440               

cac agt gcc cag aaa cca tac acc tgt aag gaa tgt ggg aag gct ttt       1635
His Ser Ala Gln Lys Pro Tyr Thr Cys Lys Glu Cys Gly Lys Ala Phe           
            445                 450                 455                   

aac tat tcc acc cac ctt aaa att cac atg cga atc cac act gga gaa       1683
Asn Tyr Ser Thr His Leu Lys Ile His Met Arg Ile His Thr Gly Glu           
        460                 465                 470                       

aaa ccc tat gag tgt aaa caa tgt gga aag gcc ttc agt cat tcc agt       1731
Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Ser His Ser Ser           
    475                 480                 485                           

tca ttt caa ata cat gaa agg act cac act gga gag aaa ccc tat gaa       1779
Ser Phe Gln Ile His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu           
490                 495                 500                 505           

tgc aag gag tgt ggg aaa gcc ttc acg tgt tcc agt tcc ttt aga att       1827
Cys Lys Glu Cys Gly Lys Ala Phe Thr Cys Ser Ser Ser Phe Arg Ile           
                510                 515                 520               

cat gaa aaa act cac aca gaa gag aaa ccc tat aaa tgt cag caa tgc       1875
His Glu Lys Thr His Thr Glu Glu Lys Pro Tyr Lys Cys Gln Gln Cys           
            525                 530                 535                   

ggg aaa gct tac agt cat ccc cgt tca ctt cga aga cat gaa caa att       1923
Gly Lys Ala Tyr Ser His Pro Arg Ser Leu Arg Arg His Glu Gln Ile           
        540                 545                 550                       

cac tag tgagaaactg tccatgtaat aaatgtggga aagctctcat ttgttccagt        1979
His                                                                       
                                                                          

tcactttaaa gacatgaatg aactcactct ggagagaaga agctgcatga aaattactta     2039

attcctgtaa tcccagcatt ttgagaggct gaggtgggtg gatcacttga ggtcaggagt     2099

ttgagaccac cctggccaac atggtgaaac cttgtctcta ctgaaaatac aaaaaattta     2159

gccaggtgtg gtgggcacct gtaatcccag ctacttggga ggctgaggca agtgaatcac     2219

ttgaacccag gaagcagagg ttgcagtgag cagagatcat gccactgcac tccagcctgg     2279

gcgatggagt gagactccat ctcaaaaaaa aaaaaaaaaa a                         2320


<210>  428
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  428

Met Ala Ala Ala Asp Leu Ser His Gly His Tyr Leu Ser Gly Asp Pro 
1               5                   10                  15      


Val Cys Leu His Glu Glu Lys Thr Pro Ala Gly Arg Ile Val Ala Asp 
            20                  25                  30          


Cys Leu Thr Asp Cys Tyr Gln Asp Ser Val Thr Phe Asp Asp Val Ala 
        35                  40                  45              


Val Asp Phe Thr Gln Glu Glu Trp Thr Leu Leu Asp Ser Thr Gln Arg 
    50                  55                  60                  


Ser Leu Tyr Ser Asp Val Met Leu Glu Asn Tyr Lys Asn Leu Ala Thr 
65                  70                  75                  80  


Val Gly Gly Gln Ile Ile Lys Pro Ser Leu Ile Ser Trp Leu Glu Gln 
                85                  90                  95      


Glu Glu Ser Arg Thr Val Gln Gly Gly Val Leu Gln Gly Trp Glu Met 
            100                 105                 110         


Arg Leu Glu Thr Gln Trp Ser Ile Leu Gln Gln Asp Phe Leu Arg Gly 
        115                 120                 125             


Gln Thr Ser Ile Gly Ile Gln Leu Glu Gly Lys His Asn Gly Arg Glu 
    130                 135                 140                 


Leu Cys Asp Cys Glu Gln Cys Gly Glu Val Phe Ser Glu His Ser Cys 
145                 150                 155                 160 


Leu Lys Thr His Val Arg Thr Gln Ser Thr Gly Asn Thr His Asp Cys 
                165                 170                 175     


Asn Gln Tyr Gly Lys Asp Phe Leu Thr Leu Cys Glu Lys Thr Ser Thr 
            180                 185                 190         


Gly Glu Lys Leu Ser Glu Phe Asn Gln Ser Glu Lys Ile Phe Ser Leu 
        195                 200                 205             


Thr Pro Asn Ile Val Tyr Gln Arg Thr Ser Thr Gln Glu Lys Ser Phe 
    210                 215                 220                 


Glu Cys Ser His Cys Gly Lys Ser Phe Ile Asn Glu Ser Tyr Leu Gln 
225                 230                 235                 240 


Ala His Met Arg Thr His Asn Gly Glu Lys Leu Tyr Glu Trp Arg Asn 
                245                 250                 255     


Tyr Gly Pro Gly Phe Ile Asp Ser Thr Ser Leu Ser Val Leu Ile Glu 
            260                 265                 270         


Thr Leu Asn Ala Lys Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Gly 
        275                 280                 285             


Tyr Arg Tyr Pro Ala Tyr Leu Ser Ile His Met Arg Thr His Thr Gly 
    290                 295                 300                 


Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Asn Tyr Ser 
305                 310                 315                 320 


Asn Ser Phe Gln Ile His Gly Arg Thr His Thr Gly Glu Lys Pro Tyr 
                325                 330                 335     


Val Cys Lys Glu Cys Gly Lys Ala Phe Thr Gln Tyr Ser Gly Leu Ser 
            340                 345                 350         


Met His Val Arg Ser His Ser Gly Asp Lys Pro Tyr Glu Cys Lys Glu 
        355                 360                 365             


Cys Gly Lys Ser Phe Leu Thr Ser Ser Arg Leu Ile Gln His Ile Arg 
    370                 375                 380                 


Thr His Thr Gly Glu Lys Pro Phe Val Cys Val Glu Cys Gly Lys Ala 
385                 390                 395                 400 


Phe Ala Val Ser Ser Asn Leu Ser Gly His Leu Arg Thr His Thr Glu 
                405                 410                 415     


Glu Lys Ala Cys Glu Cys Lys Ile Cys Gly Lys Val Phe Gly Tyr Pro 
            420                 425                 430         


Ser Cys Leu Asn Asn His Met Arg Thr His Ser Ala Gln Lys Pro Tyr 
        435                 440                 445             


Thr Cys Lys Glu Cys Gly Lys Ala Phe Asn Tyr Ser Thr His Leu Lys 
    450                 455                 460                 


Ile His Met Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln 
465                 470                 475                 480 


Cys Gly Lys Ala Phe Ser His Ser Ser Ser Phe Gln Ile His Glu Arg 
                485                 490                 495     


Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala 
            500                 505                 510         


Phe Thr Cys Ser Ser Ser Phe Arg Ile His Glu Lys Thr His Thr Glu 
        515                 520                 525             


Glu Lys Pro Tyr Lys Cys Gln Gln Cys Gly Lys Ala Tyr Ser His Pro 
    530                 535                 540                 


Arg Ser Leu Arg Arg His Glu Gln Ile His 
545                 550                 


<210>  429
<211>  7805
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (78)..(5588)

<400>  429
ccagcacccc ggggctgcgc actgcagctc cccaggccac ccaccaccct tctggtctct       60

gagcccagga tgcgagg atg gcc aga cca tct ctg tgc acc ctg gtg cct         110
                   Met Ala Arg Pro Ser Leu Cys Thr Leu Val Pro            
                   1               5                   10                 

ctg ggc cct gag tgc ttg cgc ccc ttc acc cgg gag tca ctg gca gcc        158
Leu Gly Pro Glu Cys Leu Arg Pro Phe Thr Arg Glu Ser Leu Ala Ala           
            15                  20                  25                    

ata gaa cag cgg gcg gtg gag gag gag gcc cgg ctg cag cgg aat aag        206
Ile Glu Gln Arg Ala Val Glu Glu Glu Ala Arg Leu Gln Arg Asn Lys           
        30                  35                  40                        

cag atg gag att gag gag ccc gaa cgg aag cca cga agt gac ttg gag        254
Gln Met Glu Ile Glu Glu Pro Glu Arg Lys Pro Arg Ser Asp Leu Glu           
    45                  50                  55                            

gct ggc aag aac cta ccc atg atc tac gga gac ccc ccg ccg gag gtc        302
Ala Gly Lys Asn Leu Pro Met Ile Tyr Gly Asp Pro Pro Pro Glu Val           
60                  65                  70                  75            

atc ggc atc ccc ctg gag gac ctg gat ccc tac tac agc aat aag aag        350
Ile Gly Ile Pro Leu Glu Asp Leu Asp Pro Tyr Tyr Ser Asn Lys Lys           
                80                  85                  90                

acc ttc atc gta ctc aac aag ggc aag gcc atc ttc cgc ttc tcc gcc        398
Thr Phe Ile Val Leu Asn Lys Gly Lys Ala Ile Phe Arg Phe Ser Ala           
            95                  100                 105                   

aca cct gct ctc tac ctg ctg agc ccc ttc agc gta gtc agg cgc ggg        446
Thr Pro Ala Leu Tyr Leu Leu Ser Pro Phe Ser Val Val Arg Arg Gly           
        110                 115                 120                       

gcc atc aag gtg ctc atc cat gcg ctg ttc agc atg ttc atc atg atc        494
Ala Ile Lys Val Leu Ile His Ala Leu Phe Ser Met Phe Ile Met Ile           
    125                 130                 135                           

acc atc ttg acc aac tgc gta ttc atg acc atg agt gac ccg cct ccc        542
Thr Ile Leu Thr Asn Cys Val Phe Met Thr Met Ser Asp Pro Pro Pro           
140                 145                 150                 155           

tgg tcc aag aat gtg gag tac acc ttc aca ggg atc tac acc ttt gag        590
Trp Ser Lys Asn Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu           
                160                 165                 170               

tcc ctc atc aag ata ctg gcc cga ggc ttc tgt gtc gac gac ttc aca        638
Ser Leu Ile Lys Ile Leu Ala Arg Gly Phe Cys Val Asp Asp Phe Thr           
            175                 180                 185                   

ttc ctc cgg gac ccc tgg aac tgg ctg gac ttc agt gtc atc atg atg        686
Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met           
        190                 195                 200                       

gcg tac ctg aca gag ttt gtg gac ttg ggc aac atc tca gcc ctg agg        734
Ala Tyr Leu Thr Glu Phe Val Asp Leu Gly Asn Ile Ser Ala Leu Arg           
    205                 210                 215                           

acc ttc cgg gtg ctg cgg gcc ctc aaa acc atc acg gtc atc cca ggg        782
Thr Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Thr Val Ile Pro Gly           
220                 225                 230                 235           

ctg aag acg atc gtg ggg gcc ctg atc cag tcg gtg aaa aag ctg tcg        830
Leu Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser           
                240                 245                 250               

gat gtg atg atc ctc act gtc ttc tgc ctg agc gtc ttt gcg ctg gta        878
Asp Val Met Ile Leu Thr Val Phe Cys Leu Ser Val Phe Ala Leu Val           
            255                 260                 265                   

gga ctg cag ctc ttc atg gga aac ctg agg cag aag tgt gtg cgc tgg        926
Gly Leu Gln Leu Phe Met Gly Asn Leu Arg Gln Lys Cys Val Arg Trp           
        270                 275                 280                       

ccc ccg ccg ttc aac gac acc aac acc acg tgg tac agc aat gac acg        974
Pro Pro Pro Phe Asn Asp Thr Asn Thr Thr Trp Tyr Ser Asn Asp Thr           
    285                 290                 295                           

tgg tac ggc aat gac aca tgg tat ggc aat gag atg tgg tac ggc aat       1022
Trp Tyr Gly Asn Asp Thr Trp Tyr Gly Asn Glu Met Trp Tyr Gly Asn           
300                 305                 310                 315           

gac tca tgg tat gcc aac gac acg tgg aac agc cat gca agc tgg gcc       1070
Asp Ser Trp Tyr Ala Asn Asp Thr Trp Asn Ser His Ala Ser Trp Ala           
                320                 325                 330               

acc aac gat acc ttt gat tgg gac gcc tac atc agt gat gaa ggg aac       1118
Thr Asn Asp Thr Phe Asp Trp Asp Ala Tyr Ile Ser Asp Glu Gly Asn           
            335                 340                 345                   

ttc tac ttc ctg gag ggc tcc aac gat gcc ctg ctc tgt ggg aac agc       1166
Phe Tyr Phe Leu Glu Gly Ser Asn Asp Ala Leu Leu Cys Gly Asn Ser           
        350                 355                 360                       

agt gat gct ggg cac tgc cct gag ggt tat gag tgc atc aag acc ggg       1214
Ser Asp Ala Gly His Cys Pro Glu Gly Tyr Glu Cys Ile Lys Thr Gly           
    365                 370                 375                           

cgg aac ccc aac tat ggc tac acc agc tat gac acc ttc agc tgg gcc       1262
Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Tyr Asp Thr Phe Ser Trp Ala           
380                 385                 390                 395           

ttc ttg gct ctc ttc cgc ctc atg aca cag gac tat tgg gag aac ctc       1310
Phe Leu Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu           
                400                 405                 410               

ttc cag ctg acc ctt cga gca gct ggc aag acc tac atg atc ttc ttc       1358
Phe Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe           
            415                 420                 425                   

gtg gtc atc atc ttc ctg ggc tct ttc tac ctc atc aat ctg atc ctg       1406
Val Val Ile Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu           
        430                 435                 440                       

gcc gtg gtg gcc atg gca tat gcc gag cag aat gag gcc acc ctg gcc       1454
Ala Val Val Ala Met Ala Tyr Ala Glu Gln Asn Glu Ala Thr Leu Ala           
    445                 450                 455                           

gag gat aag gag aaa gag gag gag ttt cag cag atg ctt gag aag ttc       1502
Glu Asp Lys Glu Lys Glu Glu Glu Phe Gln Gln Met Leu Glu Lys Phe           
460                 465                 470                 475           

aaa aag cac cag gag gag ctg gag aag gcc aag gcc gcc caa gct ctg       1550
Lys Lys His Gln Glu Glu Leu Glu Lys Ala Lys Ala Ala Gln Ala Leu           
                480                 485                 490               

gaa ggt ggg gag gca gat ggg gac cca gcc cat ggc aaa gac tgc aat       1598
Glu Gly Gly Glu Ala Asp Gly Asp Pro Ala His Gly Lys Asp Cys Asn           
            495                 500                 505                   

ggc agc ctg gac aca tcg caa ggg gag aag gga gcc ccg agg cag agc       1646
Gly Ser Leu Asp Thr Ser Gln Gly Glu Lys Gly Ala Pro Arg Gln Ser           
        510                 515                 520                       

agc agc gga gac agc ggc atc tcc gac gcc atg gaa gaa ctg gaa gag       1694
Ser Ser Gly Asp Ser Gly Ile Ser Asp Ala Met Glu Glu Leu Glu Glu           
    525                 530                 535                           

gcc cac caa aag tgc cca cca tgg tgg tac aag tgc gcc cac aaa gtg       1742
Ala His Gln Lys Cys Pro Pro Trp Trp Tyr Lys Cys Ala His Lys Val           
540                 545                 550                 555           

ctc ata tgg aac tgc tgc gcc ccg tgg ctg aag ttc aag aac atc atc       1790
Leu Ile Trp Asn Cys Cys Ala Pro Trp Leu Lys Phe Lys Asn Ile Ile           
                560                 565                 570               

cac ctg atc gtc atg gac ccg ttc gtg gac ctg ggc atc acc atc tgc       1838
His Leu Ile Val Met Asp Pro Phe Val Asp Leu Gly Ile Thr Ile Cys           
            575                 580                 585                   

atc gtg ctc aac acc ctc ttc atg gcc atg gaa cat tac ccc atg acg       1886
Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr           
        590                 595                 600                       

gag cac ttt gac aac gtg ctc act gtg ggc aac ctg gtc ttc aca ggc       1934
Glu His Phe Asp Asn Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly           
    605                 610                 615                           

atc ttc aca gca gag atg gtt ctg aag ctg att gcc atg gac ccc tac       1982
Ile Phe Thr Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr           
620                 625                 630                 635           

gag tat ttc cag cag ggt tgg aat atc ttc gac agc atc atc gtc acc       2030
Glu Tyr Phe Gln Gln Gly Trp Asn Ile Phe Asp Ser Ile Ile Val Thr           
                640                 645                 650               

ctc agc ctg gta gag cta ggc ctg gcc aac gta cag gga ctg tct gtg       2078
Leu Ser Leu Val Glu Leu Gly Leu Ala Asn Val Gln Gly Leu Ser Val           
            655                 660                 665                   

cta cgc tcc ttc cgt ctg ctg cgg gtc ttc aag ctg gcc aag tcg tgg       2126
Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp           
        670                 675                 680                       

cca acg ctg aac atg ctc atc aag atc att ggc aat tca gtg ggg gcg       2174
Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala           
    685                 690                 695                           

ctg ggt aac ctg acg ctg gtg ctg gct atc atc gtg ttc atc ttc gcc       2222
Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala           
700                 705                 710                 715           

gtg gtg ggc atg cag ctg ttt ggc aag agc tac aag gag tgc gtg tgc       2270
Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys           
                720                 725                 730               

aag att gcc ttg gac tgc aac ctg ccg cgc tgg cac atg cat gat ttc       2318
Lys Ile Ala Leu Asp Cys Asn Leu Pro Arg Trp His Met His Asp Phe           
            735                 740                 745                   

ttc cac tcc ttc ctc atc gtc ttc cgc atc ctg tgc ggg gag tgg atc       2366
Phe His Ser Phe Leu Ile Val Phe Arg Ile Leu Cys Gly Glu Trp Ile           
        750                 755                 760                       

gag acc atg tgg gac tgc atg gag gtg gcc ggc caa gcc atg tgc ctc       2414
Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu           
    765                 770                 775                           

acc gtc ttc ctc atg gtc atg gtc atc ggc aat ctt gtg gtc ctg aac       2462
Thr Val Phe Leu Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn           
780                 785                 790                 795           

ctg ttc ctg gct ctg ctg ctg agc tcc ttc agc gcc gac agt ctg gca       2510
Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala Asp Ser Leu Ala           
                800                 805                 810               

gcc tcg gat gag gat ggc gag atg aac aac ctg cag att gcc atc ggg       2558
Ala Ser Asp Glu Asp Gly Glu Met Asn Asn Leu Gln Ile Ala Ile Gly           
            815                 820                 825                   

cgc atc aag ttg ggc atc ggc ttt gcc aag gcc ttc ctc ctg ggg ctg       2606
Arg Ile Lys Leu Gly Ile Gly Phe Ala Lys Ala Phe Leu Leu Gly Leu           
        830                 835                 840                       

ctg cat ggc aag atc ctg agc ccc aag gac atc atg ctc agc ctc ggg       2654
Leu His Gly Lys Ile Leu Ser Pro Lys Asp Ile Met Leu Ser Leu Gly           
    845                 850                 855                           

gag gct gac ggg gcc ggg gag gct gga gag gcg ggg gag act gcc ccc       2702
Glu Ala Asp Gly Ala Gly Glu Ala Gly Glu Ala Gly Glu Thr Ala Pro           
860                 865                 870                 875           

gag gat gag aag aag gag ccg ccc gag gag gac ctg aag aag gac aat       2750
Glu Asp Glu Lys Lys Glu Pro Pro Glu Glu Asp Leu Lys Lys Asp Asn           
                880                 885                 890               

cac atc ctg aac cac atg ggc ctg gct gac ggc ccc cca tcc agc ctc       2798
His Ile Leu Asn His Met Gly Leu Ala Asp Gly Pro Pro Ser Ser Leu           
            895                 900                 905                   

gag ctg gac cac ctt aac ttc atc aac aac ccc tac ctg acc ata cag       2846
Glu Leu Asp His Leu Asn Phe Ile Asn Asn Pro Tyr Leu Thr Ile Gln           
        910                 915                 920                       

gtg ccc atc gcc tcc gag gag tcc gac ctg gag atg ccc acc gag gag       2894
Val Pro Ile Ala Ser Glu Glu Ser Asp Leu Glu Met Pro Thr Glu Glu           
    925                 930                 935                           

gaa acc gac act ttc tca gag cct gag gat agc aag aag ccg ccg cag       2942
Glu Thr Asp Thr Phe Ser Glu Pro Glu Asp Ser Lys Lys Pro Pro Gln           
940                 945                 950                 955           

cct ctc tat gat ggg aac tcg tcc gtc tgc agc aca gct gac tac aag       2990
Pro Leu Tyr Asp Gly Asn Ser Ser Val Cys Ser Thr Ala Asp Tyr Lys           
                960                 965                 970               

ccc ccc gag gag gac cct gag gag cag gca gag gag aac ccc gag ggg       3038
Pro Pro Glu Glu Asp Pro Glu Glu Gln Ala Glu Glu Asn Pro Glu Gly           
            975                 980                 985                   

gag cag cct gag gag tgc ttc act gag gcc tgc gtg cag  cgc tgg ccc      3086
Glu Gln Pro Glu Glu Cys Phe Thr Glu Ala Cys Val Gln  Arg Trp Pro          
        990                 995                 1000                      

tgc ctc  tac gtg gac atc tcc  cag ggc cgt ggg aag  aag tgg tgg        3131
Cys Leu  Tyr Val Asp Ile Ser  Gln Gly Arg Gly Lys  Lys Trp Trp            
    1005                 1010                 1015                        

act ctg  cgc agg gcc tgc ttc  aag att gtc gag cac  aac tgg ttc        3176
Thr Leu  Arg Arg Ala Cys Phe  Lys Ile Val Glu His  Asn Trp Phe            
    1020                 1025                 1030                        

gag acc  ttc att gtc ttc atg  atc ctg ctc agc agt  ggg gct ctg        3221
Glu Thr  Phe Ile Val Phe Met  Ile Leu Leu Ser Ser  Gly Ala Leu            
    1035                 1040                 1045                        

gcc ttc  gag gac atc tac att  gag cag cgg cga gtc  att cgc acc        3266
Ala Phe  Glu Asp Ile Tyr Ile  Glu Gln Arg Arg Val  Ile Arg Thr            
    1050                 1055                 1060                        

atc cta  gaa tat gcc gac aag  gtc ttc acc tac atc  ttc atc atg        3311
Ile Leu  Glu Tyr Ala Asp Lys  Val Phe Thr Tyr Ile  Phe Ile Met            
    1065                 1070                 1075                        

gag atg  ctg ctc aaa tgg gtg  gcc tac ggc ttt aag  gtg tac ttc        3356
Glu Met  Leu Leu Lys Trp Val  Ala Tyr Gly Phe Lys  Val Tyr Phe            
    1080                 1085                 1090                        

acc aac  gcc tgg tgc tgg ctc  gac ttc ctc atc gtg  gat gtc tcc        3401
Thr Asn  Ala Trp Cys Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser            
    1095                 1100                 1105                        

atc atc  agc ttg gtg gcc aac  tgg ctg ggc tac tcg  gag ctg gga        3446
Ile Ile  Ser Leu Val Ala Asn  Trp Leu Gly Tyr Ser  Glu Leu Gly            
    1110                 1115                 1120                        

ccc atc  aaa tcc ctg cgg aca  ctg cgg gcc ctg cgt  ccc ctg agg        3491
Pro Ile  Lys Ser Leu Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg            
    1125                 1130                 1135                        

gca ctg  tcc cga ttc gag ggc  atg agg gtg gtg gtg  aac gcc ctc        3536
Ala Leu  Ser Arg Phe Glu Gly  Met Arg Val Val Val  Asn Ala Leu            
    1140                 1145                 1150                        

cta ggc  gcc atc ccc tcc atc  atg aat gtg ctg ctt  gtc tgc ctc        3581
Leu Gly  Ala Ile Pro Ser Ile  Met Asn Val Leu Leu  Val Cys Leu            
    1155                 1160                 1165                        

atc ttc  tgg ctg atc ttc agc  atc atg ggt gtc aac  ctg ttt gcc        3626
Ile Phe  Trp Leu Ile Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala            
    1170                 1175                 1180                        

ggc aag  ttc tac tac tgc atc  aac acc acc acc tct  gag agg ttc        3671
Gly Lys  Phe Tyr Tyr Cys Ile  Asn Thr Thr Thr Ser  Glu Arg Phe            
    1185                 1190                 1195                        

gac atc  tcc gag gtc aac aac  aag tct gag tgc gag  agc ctc atg        3716
Asp Ile  Ser Glu Val Asn Asn  Lys Ser Glu Cys Glu  Ser Leu Met            
    1200                 1205                 1210                        

cac aca  ggc cag gtc cgc tgg  ctc aat gtc aag gtc  aac tac gac        3761
His Thr  Gly Gln Val Arg Trp  Leu Asn Val Lys Val  Asn Tyr Asp            
    1215                 1220                 1225                        

aac gtg  ggt ctg ggc tac ctc  tcc ctc ctg cag gtg  gcc acc ttc        3806
Asn Val  Gly Leu Gly Tyr Leu  Ser Leu Leu Gln Val  Ala Thr Phe            
    1230                 1235                 1240                        

aag ggt  tgg atg gac atc atg  tat gca gcc gtg gac  tcc cgg gag        3851
Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala Val Asp  Ser Arg Glu            
    1245                 1250                 1255                        

aag gag  gag cag ccg cag tac  gag gtg aac ctc tac  atg tac ctc        3896
Lys Glu  Glu Gln Pro Gln Tyr  Glu Val Asn Leu Tyr  Met Tyr Leu            
    1260                 1265                 1270                        

tac ttt  gtc atc ttc atc atc  ttt ggc tcc ttc ttc  acc ctc aac        3941
Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser Phe Phe  Thr Leu Asn            
    1275                 1280                 1285                        

ctc ttc  att ggc gtc atc att  gac aac ttc aac cag  cag aag aag        3986
Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe Asn Gln  Gln Lys Lys            
    1290                 1295                 1300                        

aag tta  ggg ggg aaa gac atc  ttt atg acg gag gaa  cag aag aaa        4031
Lys Leu  Gly Gly Lys Asp Ile  Phe Met Thr Glu Glu  Gln Lys Lys            
    1305                 1310                 1315                        

tac tat  aac gcc atg aag aag  ctt ggc tcc aag aag  cct cag aag        4076
Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser Lys Lys  Pro Gln Lys            
    1320                 1325                 1330                        

cca att  ccc cgg ccc cag aac  aag atc cag ggc atg  gtg tat gac        4121
Pro Ile  Pro Arg Pro Gln Asn  Lys Ile Gln Gly Met  Val Tyr Asp            
    1335                 1340                 1345                        

ctc gtg  acg aag cag gcc ttc  gac atc acc atc atg  atc ctc atc        4166
Leu Val  Thr Lys Gln Ala Phe  Asp Ile Thr Ile Met  Ile Leu Ile            
    1350                 1355                 1360                        

tgc ctc  aac atg gtc acc atg  atg gtg gag aca gac  aac cag agc        4211
Cys Leu  Asn Met Val Thr Met  Met Val Glu Thr Asp  Asn Gln Ser            
    1365                 1370                 1375                        

cag ctc  aag gtg gac atc ctg  tac aac atc aac atg  atc ttc atc        4256
Gln Leu  Lys Val Asp Ile Leu  Tyr Asn Ile Asn Met  Ile Phe Ile            
    1380                 1385                 1390                        

atc atc  ttc aca ggg gag tgc  gtg ctc aag atg ctc  gcc ctg cgc        4301
Ile Ile  Phe Thr Gly Glu Cys  Val Leu Lys Met Leu  Ala Leu Arg            
    1395                 1400                 1405                        

cag tac  tac ttc acc gtt ggc  tgg aac atc ttt gac  ttc gtg gtc        4346
Gln Tyr  Tyr Phe Thr Val Gly  Trp Asn Ile Phe Asp  Phe Val Val            
    1410                 1415                 1420                        

gtc atc  ctg tcc att gtg ggc  ctt gcc ctc tct gac  ctg atc cag        4391
Val Ile  Leu Ser Ile Val Gly  Leu Ala Leu Ser Asp  Leu Ile Gln            
    1425                 1430                 1435                        

aag tac  ttc gtg tca ccc acg  ctg ttc cgt gtg atc  cgc ctg gcg        4436
Lys Tyr  Phe Val Ser Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala            
    1440                 1445                 1450                        

cgg att  ggg cgt gtc ctg cgg  ctg atc cgc ggg gcc  aag ggc atc        4481
Arg Ile  Gly Arg Val Leu Arg  Leu Ile Arg Gly Ala  Lys Gly Ile            
    1455                 1460                 1465                        

cgg acg  ctg ctg ttc gcc ctc  atg atg tcg ctg cct  gcc ctc ttc        4526
Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe            
    1470                 1475                 1480                        

aac atc  ggc ctc ctc ctc ttc  ctg gtc atg ttc atc  tac tcc atc        4571
Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met Phe Ile  Tyr Ser Ile            
    1485                 1490                 1495                        

ttc ggc  atg tcc aac ttt gcc  tac gtc aag aag gag  tcg ggc atc        4616
Phe Gly  Met Ser Asn Phe Ala  Tyr Val Lys Lys Glu  Ser Gly Ile            
    1500                 1505                 1510                        

gat gat  atg ttc aac ttc gag  acc ttc ggc aac agc  atc atc tgc        4661
Asp Asp  Met Phe Asn Phe Glu  Thr Phe Gly Asn Ser  Ile Ile Cys            
    1515                 1520                 1525                        

ctg ttc  gag atc acc acg tcg  gcc ggc tgg gac ggg  ctc ctc aac        4706
Leu Phe  Glu Ile Thr Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Asn            
    1530                 1535                 1540                        

ccc atc  ctc aac agc ggg ccc  cca gac tgt gac ccc  aac ctg gag        4751
Pro Ile  Leu Asn Ser Gly Pro  Pro Asp Cys Asp Pro  Asn Leu Glu            
    1545                 1550                 1555                        

aac ccg  ggc acc agt gtc aag  ggt gac tgc ggc aac  ccc tcc atc        4796
Asn Pro  Gly Thr Ser Val Lys  Gly Asp Cys Gly Asn  Pro Ser Ile            
    1560                 1565                 1570                        

ggc atc  tgc ttc ttc tgc agc  tat atc atc atc tcc  ttc ctc atc        4841
Gly Ile  Cys Phe Phe Cys Ser  Tyr Ile Ile Ile Ser  Phe Leu Ile            
    1575                 1580                 1585                        

gtg gtc  aac atg tac atc gcc  atc atc ctg gag aac  ttc aat gtg        4886
Val Val  Asn Met Tyr Ile Ala  Ile Ile Leu Glu Asn  Phe Asn Val            
    1590                 1595                 1600                        

gcc aca  gag gag agc agc gag  ccc ctt ggt gaa gat  gac ttt gag        4931
Ala Thr  Glu Glu Ser Ser Glu  Pro Leu Gly Glu Asp  Asp Phe Glu            
    1605                 1610                 1615                        

atg ttc  tac gag aca tgg gag  aag ttc gac ccc gac  gcc acc cag        4976
Met Phe  Tyr Glu Thr Trp Glu  Lys Phe Asp Pro Asp  Ala Thr Gln            
    1620                 1625                 1630                        

ttc atc  gcc tac agc cgc ctc  tca gac ttc gtg gac  acc ctg cag        5021
Phe Ile  Ala Tyr Ser Arg Leu  Ser Asp Phe Val Asp  Thr Leu Gln            
    1635                 1640                 1645                        

gaa ccg  ctg agg att gcc aag  ccc aac aag atc aag  ctc atc aca        5066
Glu Pro  Leu Arg Ile Ala Lys  Pro Asn Lys Ile Lys  Leu Ile Thr            
    1650                 1655                 1660                        

ctg gac  ttg ccc atg gtg cca  ggg gac aag atc cac  tgc ctg gac        5111
Leu Asp  Leu Pro Met Val Pro  Gly Asp Lys Ile His  Cys Leu Asp            
    1665                 1670                 1675                        

atc ctc  ttt gcc ctg acc aaa  gag gtc ctg ggt gac  tct ggg gaa        5156
Ile Leu  Phe Ala Leu Thr Lys  Glu Val Leu Gly Asp  Ser Gly Glu            
    1680                 1685                 1690                        

atg gac  gcc ctc aag cag acc  atg gag gag aag ttc  atg gca gcc        5201
Met Asp  Ala Leu Lys Gln Thr  Met Glu Glu Lys Phe  Met Ala Ala            
    1695                 1700                 1705                        

aac ccc  tcc aag gtg tcc tac  gag ccc atc acc acc  acc ctc aag        5246
Asn Pro  Ser Lys Val Ser Tyr  Glu Pro Ile Thr Thr  Thr Leu Lys            
    1710                 1715                 1720                        

agg aag  cac gag gag gtg tgc  gcc atc aag atc cag  agg gcc tac        5291
Arg Lys  His Glu Glu Val Cys  Ala Ile Lys Ile Gln  Arg Ala Tyr            
    1725                 1730                 1735                        

cgc cgg  cac ctg cta cag cgc  tcc atg aag cag gca  tcc tac atg        5336
Arg Arg  His Leu Leu Gln Arg  Ser Met Lys Gln Ala  Ser Tyr Met            
    1740                 1745                 1750                        

tac cgc  cac agc cac gac ggc  agc ggg gat gac gcc  cct gag aag        5381
Tyr Arg  His Ser His Asp Gly  Ser Gly Asp Asp Ala  Pro Glu Lys            
    1755                 1760                 1765                        

gag ggg  ctg ctt gcc aac acc  atg agc aag atg tat  ggc cac gag        5426
Glu Gly  Leu Leu Ala Asn Thr  Met Ser Lys Met Tyr  Gly His Glu            
    1770                 1775                 1780                        

aat ggg  aac agc agc tcg cca  agc ccg gag gag aag  ggc gag gca        5471
Asn Gly  Asn Ser Ser Ser Pro  Ser Pro Glu Glu Lys  Gly Glu Ala            
    1785                 1790                 1795                        

ggg gac  gcc gga ccc act atg  ggg ctg atg ccc atc  agc ccc tca        5516
Gly Asp  Ala Gly Pro Thr Met  Gly Leu Met Pro Ile  Ser Pro Ser            
    1800                 1805                 1810                        

gac act  gcc tgg cct ccc gcc  cct ccc cca ggg cag  act gtg cgc        5561
Asp Thr  Ala Trp Pro Pro Ala  Pro Pro Pro Gly Gln  Thr Val Arg            
    1815                 1820                 1825                        

cca ggt  gtc aag gag tct ctt  gtc tag caggcagcat cggggtggcc           5608
Pro Gly  Val Lys Glu Ser Leu  Val                                         
    1830                 1835                                             

cactgagtct cggcatagtc cccagagctc ccccgtggtg cctgcacaca gagtgaggga     5668

ggagggcttt gaatctggga ctgtgcctgg ctccctgatg ggggacagga tttggccaca     5728

ctggggctga cacccaggcc cgagcgcctg cgttcccaga ccatgggaaa tgggaattgc     5788

gctcaggggc tccatgctgg gtctgaggcc cctgcctcca agatttaacc tgcaagttgc     5848

tctgacctcc tctgggccct gtcgcccctc cttttggcct gggggaggtc agaacattcg     5908

aatctctgcc cctcacttga ggaggagctg gcctgcggtg gagggatcag ttgcccccca     5968

tcaccagagt cttaagggtc actggcctct ccccaggaag tggctcagac ccctcagccc     6028

cagcccagac aaagatgtct taacctcagg gagtgcagac acctaacccc agggcactgc     6088

cagcccaccc cctttgactc tggggtgcag cttcacccac caggccagct caggaattcc     6148

ctggaaaagg gaaatgtgac tggttcagaa atagctcctc aaagcctcaa aacctgattg     6208

gccactggat cctgctgctt tgggctggga tggtgactcc tgaaacctct tcctaggcca     6268

cgtccaggtc cgtagctccc ctggctggct cctaggggaa gagcagaagg aaggatgcca     6328

cttgggaatg aattgtcctt ttctaggaag cacgggggag tgagacaggc tgggtcctgc     6388

cagctggatc gctgcacatg gcctgagcat ccagacctga gcgggagtca gggacctgct     6448

gctcagtaag aagattctcg ccccttccct ctctccctgc ctcactcctc cgtgagcacc     6508

accagggctc caggagcctc atccagcctc agagatctcc cttctcatct ccccacgccc     6568

gtctctttct cacctttccc acctctctcc ccaaagtgat cctaagaatg tacagttgag     6628

ctcaggttag atatttcgac cctggggcgt gcagcaggga aggcccaact ggttcaggct     6688

caaccttcca acttcctgtg gcctgaagaa gcacttctgc tgcatcgctg ttctgggcat     6748

ggcagggcca ggcctctgct ggctcaggag gaggggtgag agacctgctc aggcgtcgct     6808

ggatttattc acttgtgtgt gtacctgtgg ctgtgtgtct gcttgtatgc ttttataggc     6868

ctgtgtgtat agctgtgtgt gtgttcaagt gcgtgactgt atgtgtgtgt gtgaaccact     6928

gtgtactgga gcctgcatta tgcacgtgtc tgggtatctt tgtatatatg tgtatatatg     6988

tgtgccctgg actgtttcaa ggtccatgga gtacggctgg tgtgtcatac tgtgcaggcc     7048

tgtccctggg agtgttcccg tgcctgggag agtggacctg tgctgtgagt gtgtggatgc     7108

gtgtgaacgc atgtggtaag gtgtgtactc agggcattct gttggcctaa gtgcctcttc     7168

tttttcttct tgtttctcat gaaaagtttg attaaaattc aggaagcagc aaaaccttca     7228

aaacaagaca tgtatgtgtg cttgagtgtg tgaacacgtg tgtgtgtgtg cacatctaca     7288

tgccatgcct atgggccaga gttgtcttta ttgtccacca tgctctctca cctgctccca     7348

gtcctgcctg aacagccctc tctctcactc ccctctcctc cccttcctgt ttctcgttgt     7408

cacacccatg gcctcagccc tgctccctgc ctcctgccta tgtctcctct atggaaggag     7468

gcctccactc cttccatctc ttccttcaga agtttcgtct aatgggggca gtctcccctt     7528

cctggcacat tgcccctctg ccttgccctc ctgggccctg ggctggcaca gcccctggag     7588

cctcagaaat ctgtttgatt ggatattctc ctcggactgt gtgcaggttg cagaggaaga     7648

gtagatgagc cgggtccggc ctctccctgc ctgtggcccc tcccctgcag acggatgccc     7708

attcctgcct ggtccagtgg ggaacaggtc ccacgccagg ccagcaggcg ggctcctttg     7768

tacagttctt acaataaacc ctccttggtg cctctgg                              7805


<210>  430
<211>  1836
<212>  PRT
<213>  Homo sapiens

<400>  430

Met Ala Arg Pro Ser Leu Cys Thr Leu Val Pro Leu Gly Pro Glu Cys 
1               5                   10                  15      


Leu Arg Pro Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ala 
            20                  25                  30          


Val Glu Glu Glu Ala Arg Leu Gln Arg Asn Lys Gln Met Glu Ile Glu 
        35                  40                  45              


Glu Pro Glu Arg Lys Pro Arg Ser Asp Leu Glu Ala Gly Lys Asn Leu 
    50                  55                  60                  


Pro Met Ile Tyr Gly Asp Pro Pro Pro Glu Val Ile Gly Ile Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Tyr Tyr Ser Asn Lys Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Ala Ile Phe Arg Phe Ser Ala Thr Pro Ala Leu Tyr 
            100                 105                 110         


Leu Leu Ser Pro Phe Ser Val Val Arg Arg Gly Ala Ile Lys Val Leu 
        115                 120                 125             


Ile His Ala Leu Phe Ser Met Phe Ile Met Ile Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Thr Met Ser Asp Pro Pro Pro Trp Ser Lys Asn Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Val Asp Asp Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Leu Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Ile Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Thr Val Ile Pro Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg Gln Lys Cys Val Arg Trp Pro Pro Pro Phe Asn 
        275                 280                 285             


Asp Thr Asn Thr Thr Trp Tyr Ser Asn Asp Thr Trp Tyr Gly Asn Asp 
    290                 295                 300                 


Thr Trp Tyr Gly Asn Glu Met Trp Tyr Gly Asn Asp Ser Trp Tyr Ala 
305                 310                 315                 320 


Asn Asp Thr Trp Asn Ser His Ala Ser Trp Ala Thr Asn Asp Thr Phe 
                325                 330                 335     


Asp Trp Asp Ala Tyr Ile Ser Asp Glu Gly Asn Phe Tyr Phe Leu Glu 
            340                 345                 350         


Gly Ser Asn Asp Ala Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly His 
        355                 360                 365             


Cys Pro Glu Gly Tyr Glu Cys Ile Lys Thr Gly Arg Asn Pro Asn Tyr 
    370                 375                 380                 


Gly Tyr Thr Ser Tyr Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe 
385                 390                 395                 400 


Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Phe Gln Leu Thr Leu 
                405                 410                 415     


Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Ile Ile Phe 
            420                 425                 430         


Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val Ala Met 
        435                 440                 445             


Ala Tyr Ala Glu Gln Asn Glu Ala Thr Leu Ala Glu Asp Lys Glu Lys 
    450                 455                 460                 


Glu Glu Glu Phe Gln Gln Met Leu Glu Lys Phe Lys Lys His Gln Glu 
465                 470                 475                 480 


Glu Leu Glu Lys Ala Lys Ala Ala Gln Ala Leu Glu Gly Gly Glu Ala 
                485                 490                 495     


Asp Gly Asp Pro Ala His Gly Lys Asp Cys Asn Gly Ser Leu Asp Thr 
            500                 505                 510         


Ser Gln Gly Glu Lys Gly Ala Pro Arg Gln Ser Ser Ser Gly Asp Ser 
        515                 520                 525             


Gly Ile Ser Asp Ala Met Glu Glu Leu Glu Glu Ala His Gln Lys Cys 
    530                 535                 540                 


Pro Pro Trp Trp Tyr Lys Cys Ala His Lys Val Leu Ile Trp Asn Cys 
545                 550                 555                 560 


Cys Ala Pro Trp Leu Lys Phe Lys Asn Ile Ile His Leu Ile Val Met 
                565                 570                 575     


Asp Pro Phe Val Asp Leu Gly Ile Thr Ile Cys Ile Val Leu Asn Thr 
            580                 585                 590         


Leu Phe Met Ala Met Glu His Tyr Pro Met Thr Glu His Phe Asp Asn 
        595                 600                 605             


Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu 
    610                 615                 620                 


Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Gln 
625                 630                 635                 640 


Gly Trp Asn Ile Phe Asp Ser Ile Ile Val Thr Leu Ser Leu Val Glu 
                645                 650                 655     


Leu Gly Leu Ala Asn Val Gln Gly Leu Ser Val Leu Arg Ser Phe Arg 
            660                 665                 670         


Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met 
        675                 680                 685             


Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr 
    690                 695                 700                 


Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln 
705                 710                 715                 720 


Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Ala Leu Asp 
                725                 730                 735     


Cys Asn Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu 
            740                 745                 750         


Ile Val Phe Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp 
        755                 760                 765             


Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Leu Met 
    770                 775                 780                 


Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu 
785                 790                 795                 800 


Leu Leu Ser Ser Phe Ser Ala Asp Ser Leu Ala Ala Ser Asp Glu Asp 
                805                 810                 815     


Gly Glu Met Asn Asn Leu Gln Ile Ala Ile Gly Arg Ile Lys Leu Gly 
            820                 825                 830         


Ile Gly Phe Ala Lys Ala Phe Leu Leu Gly Leu Leu His Gly Lys Ile 
        835                 840                 845             


Leu Ser Pro Lys Asp Ile Met Leu Ser Leu Gly Glu Ala Asp Gly Ala 
    850                 855                 860                 


Gly Glu Ala Gly Glu Ala Gly Glu Thr Ala Pro Glu Asp Glu Lys Lys 
865                 870                 875                 880 


Glu Pro Pro Glu Glu Asp Leu Lys Lys Asp Asn His Ile Leu Asn His 
                885                 890                 895     


Met Gly Leu Ala Asp Gly Pro Pro Ser Ser Leu Glu Leu Asp His Leu 
            900                 905                 910         


Asn Phe Ile Asn Asn Pro Tyr Leu Thr Ile Gln Val Pro Ile Ala Ser 
        915                 920                 925             


Glu Glu Ser Asp Leu Glu Met Pro Thr Glu Glu Glu Thr Asp Thr Phe 
    930                 935                 940                 


Ser Glu Pro Glu Asp Ser Lys Lys Pro Pro Gln Pro Leu Tyr Asp Gly 
945                 950                 955                 960 


Asn Ser Ser Val Cys Ser Thr Ala Asp Tyr Lys Pro Pro Glu Glu Asp 
                965                 970                 975     


Pro Glu Glu Gln Ala Glu Glu Asn Pro Glu Gly Glu Gln Pro Glu Glu 
            980                 985                 990         


Cys Phe Thr Glu Ala Cys Val Gln  Arg Trp Pro Cys Leu  Tyr Val Asp 
        995                 1000                 1005             


Ile Ser  Gln Gly Arg Gly Lys  Lys Trp Trp Thr Leu  Arg Arg Ala 
    1010                 1015                 1020             


Cys Phe  Lys Ile Val Glu His  Asn Trp Phe Glu Thr  Phe Ile Val 
    1025                 1030                 1035             


Phe Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1040                 1045                 1050             


Tyr Ile  Glu Gln Arg Arg Val  Ile Arg Thr Ile Leu  Glu Tyr Ala 
    1055                 1060                 1065             


Asp Lys  Val Phe Thr Tyr Ile  Phe Ile Met Glu Met  Leu Leu Lys 
    1070                 1075                 1080             


Trp Val  Ala Tyr Gly Phe Lys  Val Tyr Phe Thr Asn  Ala Trp Cys 
    1085                 1090                 1095             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Ile Ile  Ser Leu Val 
    1100                 1105                 1110             


Ala Asn  Trp Leu Gly Tyr Ser  Glu Leu Gly Pro Ile  Lys Ser Leu 
    1115                 1120                 1125             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1130                 1135                 1140             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Leu Gly  Ala Ile Pro 
    1145                 1150                 1155             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1160                 1165                 1170             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Tyr 
    1175                 1180                 1185             


Cys Ile  Asn Thr Thr Thr Ser  Glu Arg Phe Asp Ile  Ser Glu Val 
    1190                 1195                 1200             


Asn Asn  Lys Ser Glu Cys Glu  Ser Leu Met His Thr  Gly Gln Val 
    1205                 1210                 1215             


Arg Trp  Leu Asn Val Lys Val  Asn Tyr Asp Asn Val  Gly Leu Gly 
    1220                 1225                 1230             


Tyr Leu  Ser Leu Leu Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp 
    1235                 1240                 1245             


Ile Met  Tyr Ala Ala Val Asp  Ser Arg Glu Lys Glu  Glu Gln Pro 
    1250                 1255                 1260             


Gln Tyr  Glu Val Asn Leu Tyr  Met Tyr Leu Tyr Phe  Val Ile Phe 
    1265                 1270                 1275             


Ile Ile  Phe Gly Ser Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val 
    1280                 1285                 1290             


Ile Ile  Asp Asn Phe Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Lys 
    1295                 1300                 1305             


Asp Ile  Phe Met Thr Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met 
    1310                 1315                 1320             


Lys Lys  Leu Gly Ser Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro 
    1325                 1330                 1335             


Gln Asn  Lys Ile Gln Gly Met  Val Tyr Asp Leu Val  Thr Lys Gln 
    1340                 1345                 1350             


Ala Phe  Asp Ile Thr Ile Met  Ile Leu Ile Cys Leu  Asn Met Val 
    1355                 1360                 1365             


Thr Met  Met Val Glu Thr Asp  Asn Gln Ser Gln Leu  Lys Val Asp 
    1370                 1375                 1380             


Ile Leu  Tyr Asn Ile Asn Met  Ile Phe Ile Ile Ile  Phe Thr Gly 
    1385                 1390                 1395             


Glu Cys  Val Leu Lys Met Leu  Ala Leu Arg Gln Tyr  Tyr Phe Thr 
    1400                 1405                 1410             


Val Gly  Trp Asn Ile Phe Asp  Phe Val Val Val Ile  Leu Ser Ile 
    1415                 1420                 1425             


Val Gly  Leu Ala Leu Ser Asp  Leu Ile Gln Lys Tyr  Phe Val Ser 
    1430                 1435                 1440             


Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala Arg Ile  Gly Arg Val 
    1445                 1450                 1455             


Leu Arg  Leu Ile Arg Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe 
    1460                 1465                 1470             


Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu 
    1475                 1480                 1485             


Leu Phe  Leu Val Met Phe Ile  Tyr Ser Ile Phe Gly  Met Ser Asn 
    1490                 1495                 1500             


Phe Ala  Tyr Val Lys Lys Glu  Ser Gly Ile Asp Asp  Met Phe Asn 
    1505                 1510                 1515             


Phe Glu  Thr Phe Gly Asn Ser  Ile Ile Cys Leu Phe  Glu Ile Thr 
    1520                 1525                 1530             


Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Asn Pro Ile  Leu Asn Ser 
    1535                 1540                 1545             


Gly Pro  Pro Asp Cys Asp Pro  Asn Leu Glu Asn Pro  Gly Thr Ser 
    1550                 1555                 1560             


Val Lys  Gly Asp Cys Gly Asn  Pro Ser Ile Gly Ile  Cys Phe Phe 
    1565                 1570                 1575             


Cys Ser  Tyr Ile Ile Ile Ser  Phe Leu Ile Val Val  Asn Met Tyr 
    1580                 1585                 1590             


Ile Ala  Ile Ile Leu Glu Asn  Phe Asn Val Ala Thr  Glu Glu Ser 
    1595                 1600                 1605             


Ser Glu  Pro Leu Gly Glu Asp  Asp Phe Glu Met Phe  Tyr Glu Thr 
    1610                 1615                 1620             


Trp Glu  Lys Phe Asp Pro Asp  Ala Thr Gln Phe Ile  Ala Tyr Ser 
    1625                 1630                 1635             


Arg Leu  Ser Asp Phe Val Asp  Thr Leu Gln Glu Pro  Leu Arg Ile 
    1640                 1645                 1650             


Ala Lys  Pro Asn Lys Ile Lys  Leu Ile Thr Leu Asp  Leu Pro Met 
    1655                 1660                 1665             


Val Pro  Gly Asp Lys Ile His  Cys Leu Asp Ile Leu  Phe Ala Leu 
    1670                 1675                 1680             


Thr Lys  Glu Val Leu Gly Asp  Ser Gly Glu Met Asp  Ala Leu Lys 
    1685                 1690                 1695             


Gln Thr  Met Glu Glu Lys Phe  Met Ala Ala Asn Pro  Ser Lys Val 
    1700                 1705                 1710             


Ser Tyr  Glu Pro Ile Thr Thr  Thr Leu Lys Arg Lys  His Glu Glu 
    1715                 1720                 1725             


Val Cys  Ala Ile Lys Ile Gln  Arg Ala Tyr Arg Arg  His Leu Leu 
    1730                 1735                 1740             


Gln Arg  Ser Met Lys Gln Ala  Ser Tyr Met Tyr Arg  His Ser His 
    1745                 1750                 1755             


Asp Gly  Ser Gly Asp Asp Ala  Pro Glu Lys Glu Gly  Leu Leu Ala 
    1760                 1765                 1770             


Asn Thr  Met Ser Lys Met Tyr  Gly His Glu Asn Gly  Asn Ser Ser 
    1775                 1780                 1785             


Ser Pro  Ser Pro Glu Glu Lys  Gly Glu Ala Gly Asp  Ala Gly Pro 
    1790                 1795                 1800             


Thr Met  Gly Leu Met Pro Ile  Ser Pro Ser Asp Thr  Ala Trp Pro 
    1805                 1810                 1815             


Pro Ala  Pro Pro Pro Gly Gln  Thr Val Arg Pro Gly  Val Lys Glu 
    1820                 1825                 1830             


Ser Leu  Val 
    1835     


<210>  431
<211>  3006
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (54)..(416)

<400>  431
gtaaaatagg ctgcaatcaa gttcacttcc aaaggcggaa ttcatgggta cat atg          56
                                                           Met            
                                                           1              

gtg tcc acg tgt gta cac ctg cag agt tgt aac atg cgg gca ttt ctc        104
Val Ser Thr Cys Val His Leu Gln Ser Cys Asn Met Arg Ala Phe Leu           
            5                   10                  15                    

ccc tca gcc cgc cat tct ggc ttc tta act tgc acc cta aca gct cga        152
Pro Ser Ala Arg His Ser Gly Phe Leu Thr Cys Thr Leu Thr Ala Arg           
        20                  25                  30                        

cag aac ctt ggc gtc cac aaa aag gac ttg agg tgg gac atg gaa gaa        200
Gln Asn Leu Gly Val His Lys Lys Asp Leu Arg Trp Asp Met Glu Glu           
    35                  40                  45                            

cag gga ccc ctc ctg gtt tgt cca ccc agc cca cac ctc cat tcc tca        248
Gln Gly Pro Leu Leu Val Cys Pro Pro Ser Pro His Leu His Ser Ser           
50                  55                  60                  65            

ccc aac cta cca ctt cag agc cgg gaa aag acc tca gag aac atc cgc        296
Pro Asn Leu Pro Leu Gln Ser Arg Glu Lys Thr Ser Glu Asn Ile Arg           
                70                  75                  80                

tcc gac tct acc gag gct cag aca gga caa caa gag tgt gct gga cac        344
Ser Asp Ser Thr Glu Ala Gln Thr Gly Gln Gln Glu Cys Ala Gly His           
            85                  90                  95                    

tgg gaa atg tgg tcc agg agc agt cac agt ccc tac aga cct ccc aca        392
Trp Glu Met Trp Ser Arg Ser Ser His Ser Pro Tyr Arg Pro Pro Thr           
        100                 105                 110                       

aat tac cgt aat gca aag cag tga acacttggga gagctccttc actcaccgac       446
Asn Tyr Arg Asn Ala Lys Gln                                               
    115                 120                                               

tctcatcagg aaaatagtga tagcatgaac ccctccagat ggttttagga ttaaaagaga      506

tacttgtgca aagcctcagc atacgagtgc tcagcccctg ccgacatgag caatgggcag      566

cgcgtccagc tgggttcctg ccccatgaga agcacacagc ctggtttggt aggtggggct      626

ccatcagggc tgtttggata cctgggtgga gcccacagac cagcccccac cttgtgtggt      686

tagggctttg ctaggaaggc ccatctgtgc gccatgacct tggaactcga tgtgagatct      746

ctggaccggc agcagcacct ggaagcttgt tggaaatgct gatctcaggt gggactccag      806

aattcccgca tctgcacctg cactcccaaa atacctcccc accaggtgat ccgaggccat      866

ggggcagtct gaagggcact gtgctggggc gtcccaccac tagaaatcca gtccggtaat      926

ctgaagatgt aagtgccccc aggaggagtg acggagtgac acaaatgaca caaggggagg      986

ggacttgtca ggtgtccact cctgactgca agttcccagg gcagaaggca atgcccccac     1046

agggactttt ccagacactc cgagtgcacc tgaattgcat tttgagtgat gctacctgct     1106

aagcaggaag agccctccag agcctcgaaa agcagagtgg aagtggtggt gcccaggacg     1166

catgggctct gatgggaaga gggaggtggg cctgagcatg ggccttcttc tccccaggtc     1226

agaggggcct ggatgcccct ggagggaaca ctgaggtcac ctctggccaa atcttcctgt     1286

tctgccagta cccagccctg ttcagtgacg tcaagctttt gggtccctgt cctggggccc     1346

tccacgctgg ccgggctgtg tagagacgcc cttctctcca ctttattggg tccagattgt     1406

tgtgtggctt ctcccctcct ctgcagcctg gggtctgaaa acagcgatgc caacagacag     1466

acagatttcc aaaagaaagg tccggctcag ccaaggacaa aggggccttg cagaggctcc     1526

tgggggtcag aaagctgaga gtctaccggg caggtgcctt ctccacccac aggcacaagc     1586

tacaacagct ttccaggaag tgcatccaca tcgtccccag gtccagatgc ccacatcgcc     1646

ctgcagggac caagaccaca ctcgggctgc ttggacagga tgtagctggt cactgttctg     1706

gagctggccc ctctgtagcc tgtgacaatc agcttgagtc tctctgccaa gtctccgcct     1766

tctgttcttc ttgccgacct tgaagcagag ttgacgtttc aggtttttcc agcagacaaa     1826

gctcactcaa tctgatactg tggaggttgt taatttaaca accaacccat cctcatgttg     1886

agaaaccagc tccaaatgct cacctggctg tcagggatgg ggagcctcat cggtgaaaga     1946

gggttgtgat ggcataattt aaaccaaaag aggcattcgc ggttgcccgt gttgcctcag     2006

gcctgctggc ctcctgctgt gaacattttg ggcaataccg tctctgccag tgacccccaa     2066

ttgtccactt gtctccagca agatcgaacc atgtaagtgc catttctgac aagttgggtg     2126

aacgttggtt tcaaatcatc agctctgcat tcaagtgccc tgctacaatt ctgcctcact     2186

ctgtgggaat aactgcctgc ctgggcacgt tgctgttgct gcctcccaaa cggcagtttc     2246

tggggtccca ggtcatccag gctggatgtg gcttgggaga gacctgtggc accaggttgg     2306

agggaggtct cacctctcct ttctgagctg tggactgcag cttcaggacc ctatggatga     2366

ggccgaatgt catgaagata atggaatttg gagtctcaac aaagccaagc cacatgccag     2426

agattcacca cctggggccc aggatcataa gtgtgccctt aagaggccaa acagtccacc     2486

tgtctaccaa ctagacattt ggtctcagac agcaagaaag gctgcgttta tgtcattagg     2546

gggaacacca cggtcttcgg catgagagag gtgtaattct caagttcatc agagctcggc     2606

ttcccccatg aggggaaaca atttgccagg ttgaagaaca cacgctttga gggttctcag     2666

aggctgacac ctgttgtgaa tcttggaaac tcaagcccca gtgcaaacgg ccttgaagga     2726

ggtcgagcat catggttcca acaagtgact cgctttgata acccgatgtg taagcagaat     2786

cgcaatgcat ccgtccttcc ctaatcatca cgtggctgtc atctggtcaa tgaactgagg     2846

cccgaaggct tgagtcaaac tggttttcaa ggctgtgctc atgggattta tatgtttctt     2906

gagccctgtt ggaggctctt ggcaggtctg aacattaaac atttcttttc ttccttttga     2966

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           3006


<210>  432
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  432

Met Val Ser Thr Cys Val His Leu Gln Ser Cys Asn Met Arg Ala Phe 
1               5                   10                  15      


Leu Pro Ser Ala Arg His Ser Gly Phe Leu Thr Cys Thr Leu Thr Ala 
            20                  25                  30          


Arg Gln Asn Leu Gly Val His Lys Lys Asp Leu Arg Trp Asp Met Glu 
        35                  40                  45              


Glu Gln Gly Pro Leu Leu Val Cys Pro Pro Ser Pro His Leu His Ser 
    50                  55                  60                  


Ser Pro Asn Leu Pro Leu Gln Ser Arg Glu Lys Thr Ser Glu Asn Ile 
65                  70                  75                  80  


Arg Ser Asp Ser Thr Glu Ala Gln Thr Gly Gln Gln Glu Cys Ala Gly 
                85                  90                  95      


His Trp Glu Met Trp Ser Arg Ser Ser His Ser Pro Tyr Arg Pro Pro 
            100                 105                 110         


Thr Asn Tyr Arg Asn Ala Lys Gln 
        115                 120 


<210>  433
<211>  2466
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (231)..(1028)

<400>  433
ggctgagtgg tttgctcctt cccctctctc tgggaggctg agcaggggtg ccgggttgct       60

caggccatgg gagccacacc tgttattgct gcctctgatt tgtgtgacac tgagaagccc      120

acaggcctgt ccctccaact cggtggaccc tctctgtgtg catttggtgt gtgagccagc      180

tctgagaagg gttcagaagc cactggaggc atctggggac ctcagcttcc atg cca         236
                                                       Met Pro            
                                                       1                  

tct ctg cct cac tcc cac agg gta atg ttg gac tcg gtg aca cac agc        284
Ser Leu Pro His Ser His Arg Val Met Leu Asp Ser Val Thr His Ser           
        5                   10                  15                        

acc ttc ctg cct aat gca tcc ttc tgc gat ccc ctg atg tcg tgg act        332
Thr Phe Leu Pro Asn Ala Ser Phe Cys Asp Pro Leu Met Ser Trp Thr           
    20                  25                  30                            

gat ctg ttc agc aat gaa gag tac tac cct gcc ttt gag cat cag aca        380
Asp Leu Phe Ser Asn Glu Glu Tyr Tyr Pro Ala Phe Glu His Gln Thr           
35                  40                  45                  50            

gcc tgt gac tca tac tgg aca tca gtc cac cct gaa tac tgg act aag        428
Ala Cys Asp Ser Tyr Trp Thr Ser Val His Pro Glu Tyr Trp Thr Lys           
                55                  60                  65                

cgc cat gtg tgg gag tgg ctc cag ttc tgc tgc gac cag tac aag ttg        476
Arg His Val Trp Glu Trp Leu Gln Phe Cys Cys Asp Gln Tyr Lys Leu           
            70                  75                  80                    

gac acc aat tgc atc tcc ttc tgc aac ttc aac atc agt ggc ctg cag        524
Asp Thr Asn Cys Ile Ser Phe Cys Asn Phe Asn Ile Ser Gly Leu Gln           
        85                  90                  95                        

ctg tgc agc atg aca cag gag gag ttc gtc gag gca gct ggc ctc tgc        572
Leu Cys Ser Met Thr Gln Glu Glu Phe Val Glu Ala Ala Gly Leu Cys           
    100                 105                 110                           

ggc gag tac ctg tac ttc atc ctc cag aac atc cgc aca caa ggt tac        620
Gly Glu Tyr Leu Tyr Phe Ile Leu Gln Asn Ile Arg Thr Gln Gly Tyr           
115                 120                 125                 130           

tcc ttt ttt aat gac gct gaa gaa agc aag gcc acc atc aaa gac tat        668
Ser Phe Phe Asn Asp Ala Glu Glu Ser Lys Ala Thr Ile Lys Asp Tyr           
                135                 140                 145               

gct gat tcc aac tgc ttg aaa aca agt ggc atc aaa agt caa gac tgt        716
Ala Asp Ser Asn Cys Leu Lys Thr Ser Gly Ile Lys Ser Gln Asp Cys           
            150                 155                 160                   

cac agt cat agt aga aca agc ctc caa agt tct cat cta tgg gaa ttt        764
His Ser His Ser Arg Thr Ser Leu Gln Ser Ser His Leu Trp Glu Phe           
        165                 170                 175                       

gta cga gac ctg ctt cta tct cct gaa gaa aac tgt ggc att ctg gaa        812
Val Arg Asp Leu Leu Leu Ser Pro Glu Glu Asn Cys Gly Ile Leu Glu           
    180                 185                 190                           

tgg gaa gat agg gaa caa gga att ttt cgg gtg gtt aaa tcg gaa gcc        860
Trp Glu Asp Arg Glu Gln Gly Ile Phe Arg Val Val Lys Ser Glu Ala           
195                 200                 205                 210           

ctg gca aag atg tgg gga caa agg aag aaa aat gac aga atg aca tat        908
Leu Ala Lys Met Trp Gly Gln Arg Lys Lys Asn Asp Arg Met Thr Tyr           
                215                 220                 225               

gaa aag ttg agc aga gcc ctg aga tac tac tat aaa aca gga att ttg        956
Glu Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Lys Thr Gly Ile Leu           
            230                 235                 240                   

gag cgg gtt gac cga agg tta gtg tac aaa ttt gga aaa aat gca cac       1004
Glu Arg Val Asp Arg Arg Leu Val Tyr Lys Phe Gly Lys Asn Ala His           
        245                 250                 255                       

ggg tgg cag gaa gac aag cta tga tctgctccag gcatcaagct cattttatgg      1058
Gly Trp Gln Glu Asp Lys Leu                                               
    260                 265                                               

atttctgtct tttaaaacaa tcagattgca atagacattc gaaaggcttc attttcttct     1118

cttttttttt aacctgcaaa catgctgata aaatttctcc acatctcagc ttacatttgg     1178

attcagagtt gttgtctacg gagggtgaga gcagaaactc ttaagaaatc ctttcttctc     1238

cctaagggga tgaggggatg atcttttgtg gtgtcttgat caaactttat tttcctagag     1298

ttgtggaatg acaacagccc atgccattga tgctgatcag agaaaaacta ttcaattctg     1358

ccattagaga cacatccaat gctcccatcc caaaggttca aaagttttca aataactgtg     1418

gcagctcacc aaaggtgggg gaaagcatga ttagtttgca ggttatggta ggagagggtg     1478

agatataaga catacatact ttagatttta aattattaaa gtcaaaaatc catagaaaag     1538

tatccctttt tttttttttg agacgggttc tcactatgtt gcccagggct ggtcttgaac     1598

tcctatgctc aagtgatcct cccacctcgg cctcccaaag tactgtgatt acaagcgtga     1658

gccacggcac ctgggcagaa aagtatctta attaatgaaa gagctaagcc atcaagctgg     1718

gacttaattg gatttaacat aggttcacag aaagtttcct aaccagagca tctttttgac     1778

cactcagcaa aacttccaca gacatccttc tggacttaaa cacttaacat taaccacatt     1838

attaattgtt gctgagttta ttcccccttc taactgatgg ctggcatctg atatgcagag     1898

ttagtcaaca gacactggca tcaattacaa aatcactgct gtttctgtga ttcaagctgt     1958

caacacaata aaatcgaaat tcattgattc catctctggt ccagatgtta aacgtttata     2018

aaaccggaaa tgtcctaaca actctgtaat ggcaaattaa attgtgtgtc ttttttgttt     2078

tgtctttcta cctgatgtgt attcaagcgc tataacacgt atttccttga caaaaatagt     2138

gacagtgaat tcacactaat aaatgttcat aggttaaagt ctgcactgac attttctcat     2198

caatcactgg tatgtaagtt atcagtgact gacagctagg tggactgccc ctaggacttc     2258

tgtttcacca gagcaggaat caagtggtga ggcactgaat cgctgtacag gctgaagacc     2318

tccttattag agttgaactt caaagtaact tgttttaaaa aatgtgaatt actgtaaaat     2378

aatctatttt ggattcatgt gttttccagg tggatatagt ttgtaaacaa tgtgaataaa     2438

gtatttaaca tgtaaaaaaa aaaaaaaa                                        2466


<210>  434
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  434

Met Pro Ser Leu Pro His Ser His Arg Val Met Leu Asp Ser Val Thr 
1               5                   10                  15      


His Ser Thr Phe Leu Pro Asn Ala Ser Phe Cys Asp Pro Leu Met Ser 
            20                  25                  30          


Trp Thr Asp Leu Phe Ser Asn Glu Glu Tyr Tyr Pro Ala Phe Glu His 
        35                  40                  45              


Gln Thr Ala Cys Asp Ser Tyr Trp Thr Ser Val His Pro Glu Tyr Trp 
    50                  55                  60                  


Thr Lys Arg His Val Trp Glu Trp Leu Gln Phe Cys Cys Asp Gln Tyr 
65                  70                  75                  80  


Lys Leu Asp Thr Asn Cys Ile Ser Phe Cys Asn Phe Asn Ile Ser Gly 
                85                  90                  95      


Leu Gln Leu Cys Ser Met Thr Gln Glu Glu Phe Val Glu Ala Ala Gly 
            100                 105                 110         


Leu Cys Gly Glu Tyr Leu Tyr Phe Ile Leu Gln Asn Ile Arg Thr Gln 
        115                 120                 125             


Gly Tyr Ser Phe Phe Asn Asp Ala Glu Glu Ser Lys Ala Thr Ile Lys 
    130                 135                 140                 


Asp Tyr Ala Asp Ser Asn Cys Leu Lys Thr Ser Gly Ile Lys Ser Gln 
145                 150                 155                 160 


Asp Cys His Ser His Ser Arg Thr Ser Leu Gln Ser Ser His Leu Trp 
                165                 170                 175     


Glu Phe Val Arg Asp Leu Leu Leu Ser Pro Glu Glu Asn Cys Gly Ile 
            180                 185                 190         


Leu Glu Trp Glu Asp Arg Glu Gln Gly Ile Phe Arg Val Val Lys Ser 
        195                 200                 205             


Glu Ala Leu Ala Lys Met Trp Gly Gln Arg Lys Lys Asn Asp Arg Met 
    210                 215                 220                 


Thr Tyr Glu Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Lys Thr Gly 
225                 230                 235                 240 


Ile Leu Glu Arg Val Asp Arg Arg Leu Val Tyr Lys Phe Gly Lys Asn 
                245                 250                 255     


Ala His Gly Trp Gln Glu Asp Lys Leu 
            260                 265 


<210>  435
<211>  6644
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (158)..(4555)

<400>  435
ttcccggacc cctgtttgct ttagagccga gccgcgccga tgccctcaca ctctgcgcct       60

cctctcccgg gactttaaca ccccgctctc ctccaccgac caggtgacct tttgctctga      120

gccagatcag agaagaattc ggtgtccgtg cgggacg atg cct gag cag gag aga       175
                                         Met Pro Glu Gln Glu Arg          
                                         1               5                

cag atc aca gcc aga gaa ggg gcc agt cgg aaa atc tta tct aag ctt        223
Gln Ile Thr Ala Arg Glu Gly Ala Ser Arg Lys Ile Leu Ser Lys Leu           
            10                  15                  20                    

tct ttg cct acc cgt gcc tgg gaa cca gca atg aag aag agt ttt gct        271
Ser Leu Pro Thr Arg Ala Trp Glu Pro Ala Met Lys Lys Ser Phe Ala           
        25                  30                  35                        

ttt gac aat gtt ggc tat gaa ggt ggt ctg gat ggc ctg ggc cct tct        319
Phe Asp Asn Val Gly Tyr Glu Gly Gly Leu Asp Gly Leu Gly Pro Ser           
    40                  45                  50                            

tct cag gtg gcc acc agc aca gtc agg atc ttg ggc atg act tgc cag        367
Ser Gln Val Ala Thr Ser Thr Val Arg Ile Leu Gly Met Thr Cys Gln           
55                  60                  65                  70            

tca tgt gtg aag tcc att gag gac agg att tcc aat ttg aaa ggc atc        415
Ser Cys Val Lys Ser Ile Glu Asp Arg Ile Ser Asn Leu Lys Gly Ile           
                75                  80                  85                

atc agc atg aag gtt tcc ctg gaa caa ggc agt gcc act gtg aaa tat        463
Ile Ser Met Lys Val Ser Leu Glu Gln Gly Ser Ala Thr Val Lys Tyr           
            90                  95                  100                   

gtg cca tcg gtt gtg tgc ctg caa cag gtt tgc cat caa att ggg gac        511
Val Pro Ser Val Val Cys Leu Gln Gln Val Cys His Gln Ile Gly Asp           
        105                 110                 115                       

atg ggc ttc gag gcc agc att gca gaa gga aag gca gcc tcc tgg ccc        559
Met Gly Phe Glu Ala Ser Ile Ala Glu Gly Lys Ala Ala Ser Trp Pro           
    120                 125                 130                           

tca agg tcc ttg cct gcc cag gag gct gtg gtc aag ctc cgg gtg gag        607
Ser Arg Ser Leu Pro Ala Gln Glu Ala Val Val Lys Leu Arg Val Glu           
135                 140                 145                 150           

ggc atg acc tgc cag tcc tgt gtc agc tcc att gaa ggc aag gtc cgg        655
Gly Met Thr Cys Gln Ser Cys Val Ser Ser Ile Glu Gly Lys Val Arg           
                155                 160                 165               

aaa ctg caa gga gta gtg aga gtc aaa gtc tca ctc agc aac caa gag        703
Lys Leu Gln Gly Val Val Arg Val Lys Val Ser Leu Ser Asn Gln Glu           
            170                 175                 180                   

gcc gtc atc act tat cag cct tat ctc att cag ccc gaa gac ctc agg        751
Ala Val Ile Thr Tyr Gln Pro Tyr Leu Ile Gln Pro Glu Asp Leu Arg           
        185                 190                 195                       

gac cat gta aat gac atg gga ttt gaa gct gcc atc aag agc aaa gtg        799
Asp His Val Asn Asp Met Gly Phe Glu Ala Ala Ile Lys Ser Lys Val           
    200                 205                 210                           

gct ccc tta agc ctg gga cca att gat att gag cgg tta caa agc act        847
Ala Pro Leu Ser Leu Gly Pro Ile Asp Ile Glu Arg Leu Gln Ser Thr           
215                 220                 225                 230           

aac cca aag aga cct tta tct tct gct aac cag aat ttt aat aat tct        895
Asn Pro Lys Arg Pro Leu Ser Ser Ala Asn Gln Asn Phe Asn Asn Ser           
                235                 240                 245               

gag acc ttg ggg cac caa gga agc cat gtg gtc acc ctc caa ctg aga        943
Glu Thr Leu Gly His Gln Gly Ser His Val Val Thr Leu Gln Leu Arg           
            250                 255                 260                   

ata gat gga atg cat tgt aag tct tgc gtc ttg aat att gaa gaa aat        991
Ile Asp Gly Met His Cys Lys Ser Cys Val Leu Asn Ile Glu Glu Asn           
        265                 270                 275                       

att ggc cag ctc cta ggg gtt caa agt att caa gtg tcc ttg gag aac       1039
Ile Gly Gln Leu Leu Gly Val Gln Ser Ile Gln Val Ser Leu Glu Asn           
    280                 285                 290                           

aaa act gcc caa gta aag tat gac cct tct tgt acc agc cca gtg gct       1087
Lys Thr Ala Gln Val Lys Tyr Asp Pro Ser Cys Thr Ser Pro Val Ala           
295                 300                 305                 310           

ctg cag agg gct atc gag gca ctt cca cct ggg aat ttt aaa gtt tct       1135
Leu Gln Arg Ala Ile Glu Ala Leu Pro Pro Gly Asn Phe Lys Val Ser           
                315                 320                 325               

ctt cct gat gga gcc gaa ggg agt ggg aca gat cac agg tct tcc agt       1183
Leu Pro Asp Gly Ala Glu Gly Ser Gly Thr Asp His Arg Ser Ser Ser           
            330                 335                 340                   

tct cat tcc cct ggc tcc cca ccg aga aac cag gtc cag ggc aca tgc       1231
Ser His Ser Pro Gly Ser Pro Pro Arg Asn Gln Val Gln Gly Thr Cys           
        345                 350                 355                       

agt acc act ctg att gcc att gcc ggc atg acc tgt gca tcc tgt gtc       1279
Ser Thr Thr Leu Ile Ala Ile Ala Gly Met Thr Cys Ala Ser Cys Val           
    360                 365                 370                           

cat tcc att gaa ggc atg atc tcc caa ctg gaa ggg gtg cag caa ata       1327
His Ser Ile Glu Gly Met Ile Ser Gln Leu Glu Gly Val Gln Gln Ile           
375                 380                 385                 390           

tcg gtg tct ttg gcc gaa ggg act gca aca gtt ctt tat aat ccc tct       1375
Ser Val Ser Leu Ala Glu Gly Thr Ala Thr Val Leu Tyr Asn Pro Ser           
                395                 400                 405               

gta att agc cca gaa gaa ctc aga gct gct ata gaa gac atg gga ttt       1423
Val Ile Ser Pro Glu Glu Leu Arg Ala Ala Ile Glu Asp Met Gly Phe           
            410                 415                 420                   

gag gct tca gtc gtt tct gaa agc tgt tct act aac cct ctt gga aac       1471
Glu Ala Ser Val Val Ser Glu Ser Cys Ser Thr Asn Pro Leu Gly Asn           
        425                 430                 435                       

cac agt gct ggg aat tcc atg gtg caa act aca gat ggt aca cct aca       1519
His Ser Ala Gly Asn Ser Met Val Gln Thr Thr Asp Gly Thr Pro Thr           
    440                 445                 450                           

tct gtg cag gaa gtg gct ccc cac act ggg agg ctc cct gca aac cat       1567
Ser Val Gln Glu Val Ala Pro His Thr Gly Arg Leu Pro Ala Asn His           
455                 460                 465                 470           

gcc ccg gac atc ttg gca aag tcc cca caa tca acc aga gca gtg gca       1615
Ala Pro Asp Ile Leu Ala Lys Ser Pro Gln Ser Thr Arg Ala Val Ala           
                475                 480                 485               

ccg cag aag tgc ttc tta cag atc aaa ggc atg acc tgt gca tcc tgt       1663
Pro Gln Lys Cys Phe Leu Gln Ile Lys Gly Met Thr Cys Ala Ser Cys           
            490                 495                 500                   

gtg tct aac ata gaa agg aat ctg cag aaa gaa gct ggt gtt ctc tcc       1711
Val Ser Asn Ile Glu Arg Asn Leu Gln Lys Glu Ala Gly Val Leu Ser           
        505                 510                 515                       

gtg ttg gtt gcc ttg atg gca gga aag gca gag atc aag tat gac cca       1759
Val Leu Val Ala Leu Met Ala Gly Lys Ala Glu Ile Lys Tyr Asp Pro           
    520                 525                 530                           

gag gtc atc cag ccc ctc gag ata gct cag ttc atc cag gac ctg ggt       1807
Glu Val Ile Gln Pro Leu Glu Ile Ala Gln Phe Ile Gln Asp Leu Gly           
535                 540                 545                 550           

ttt gag gca gca gtc atg gag gac tac gca ggc tcc gat ggc aac att       1855
Phe Glu Ala Ala Val Met Glu Asp Tyr Ala Gly Ser Asp Gly Asn Ile           
                555                 560                 565               

gag ctg aca atc aca ggg atg acc tgc gcg tcc tgt gtc cac aac ata       1903
Glu Leu Thr Ile Thr Gly Met Thr Cys Ala Ser Cys Val His Asn Ile           
            570                 575                 580                   

gag tcc aaa ctc acg agg aca aat ggc atc act tat gcc tcc gtt gcc       1951
Glu Ser Lys Leu Thr Arg Thr Asn Gly Ile Thr Tyr Ala Ser Val Ala           
        585                 590                 595                       

ctt gcc acc agc aaa gcc ctt gtt aag ttt gac ccg gaa att atc ggt       1999
Leu Ala Thr Ser Lys Ala Leu Val Lys Phe Asp Pro Glu Ile Ile Gly           
    600                 605                 610                           

cca cgg gat att atc aaa att att gag gaa att ggc ttt cat gct tcc       2047
Pro Arg Asp Ile Ile Lys Ile Ile Glu Glu Ile Gly Phe His Ala Ser           
615                 620                 625                 630           

ctg gcc cag aga aac ccc aac gct cat cac ttg gac cac aag atg gaa       2095
Leu Ala Gln Arg Asn Pro Asn Ala His His Leu Asp His Lys Met Glu           
                635                 640                 645               

ata aag cag tgg aag aag tct ttc ctg tgc agc ctg gtg ttt ggc atc       2143
Ile Lys Gln Trp Lys Lys Ser Phe Leu Cys Ser Leu Val Phe Gly Ile           
            650                 655                 660                   

cct gtc atg gcc tta atg atc tat atg ctg ata ccc agc aac gag ccc       2191
Pro Val Met Ala Leu Met Ile Tyr Met Leu Ile Pro Ser Asn Glu Pro           
        665                 670                 675                       

cac cag tcc atg gtc ctg gac cac aac atc att cca gga ctg tcc att       2239
His Gln Ser Met Val Leu Asp His Asn Ile Ile Pro Gly Leu Ser Ile           
    680                 685                 690                           

cta aat ctc atc ttc ttt atc ttg tgt acc ttt gtc cag ctc ctc ggt       2287
Leu Asn Leu Ile Phe Phe Ile Leu Cys Thr Phe Val Gln Leu Leu Gly           
695                 700                 705                 710           

ggg tgg tac ttc tac gtt cag gcc tac aaa tct ctg aga cac agg tca       2335
Gly Trp Tyr Phe Tyr Val Gln Ala Tyr Lys Ser Leu Arg His Arg Ser           
                715                 720                 725               

gcc aac atg gac gtg ctc atc gtc ctg gcc aca agc att gct tat gtt       2383
Ala Asn Met Asp Val Leu Ile Val Leu Ala Thr Ser Ile Ala Tyr Val           
            730                 735                 740                   

tat tct ctg gtc atc ctg gtg gtt gct gtg gct gag aag gcg gag agg       2431
Tyr Ser Leu Val Ile Leu Val Val Ala Val Ala Glu Lys Ala Glu Arg           
        745                 750                 755                       

agc cct gtg aca ttc ttc gac acg ccc ccc atg ctc ttt gtg ttc att       2479
Ser Pro Val Thr Phe Phe Asp Thr Pro Pro Met Leu Phe Val Phe Ile           
    760                 765                 770                           

gcc ctg ggc cgg tgg ctg gaa cac ttg gca aag agc aaa acc tca gaa       2527
Ala Leu Gly Arg Trp Leu Glu His Leu Ala Lys Ser Lys Thr Ser Glu           
775                 780                 785                 790           

gcc ctg gct aaa ctc atg tct ctc caa gcc aca gaa gcc acc gtt gtg       2575
Ala Leu Ala Lys Leu Met Ser Leu Gln Ala Thr Glu Ala Thr Val Val           
                795                 800                 805               

acc ctt ggt gag gac aat tta atc atc agg gag gag caa gtc ccc atg       2623
Thr Leu Gly Glu Asp Asn Leu Ile Ile Arg Glu Glu Gln Val Pro Met           
            810                 815                 820                   

gag ctg gtg cag cgg ggc gat atc gtc aag gtg gtc cct ggg gga aag       2671
Glu Leu Val Gln Arg Gly Asp Ile Val Lys Val Val Pro Gly Gly Lys           
        825                 830                 835                       

ttt cca gtg gat ggg aaa gtc ctg gaa ggc aat acc atg gct gat gag       2719
Phe Pro Val Asp Gly Lys Val Leu Glu Gly Asn Thr Met Ala Asp Glu           
    840                 845                 850                           

tcc ctc atc aca gga gaa gcc atg cca gtc act aag aaa ccc gga agc       2767
Ser Leu Ile Thr Gly Glu Ala Met Pro Val Thr Lys Lys Pro Gly Ser           
855                 860                 865                 870           

act gta att gcg ggg tct ata aat gca cat ggc tct gtg ctc att aaa       2815
Thr Val Ile Ala Gly Ser Ile Asn Ala His Gly Ser Val Leu Ile Lys           
                875                 880                 885               

gct acc cac gtg ggc aat gac acc act ttg gct cag att gtg aaa ctg       2863
Ala Thr His Val Gly Asn Asp Thr Thr Leu Ala Gln Ile Val Lys Leu           
            890                 895                 900                   

gtg gaa gag gct cag atg tca aag gca ccc att cag cag ctg gct gac       2911
Val Glu Glu Ala Gln Met Ser Lys Ala Pro Ile Gln Gln Leu Ala Asp           
        905                 910                 915                       

cgg ttt agt gga tat ttt gtc cca ttt atc atc atc atg tca act ttg       2959
Arg Phe Ser Gly Tyr Phe Val Pro Phe Ile Ile Ile Met Ser Thr Leu           
    920                 925                 930                           

acg ttg gtg gta tgg att gta atc ggt ttt atc gat ttt ggt gtt gtt       3007
Thr Leu Val Val Trp Ile Val Ile Gly Phe Ile Asp Phe Gly Val Val           
935                 940                 945                 950           

cag aga tac ttt cct aac ccc aac aag cac atc tcc cag aca gag gtg       3055
Gln Arg Tyr Phe Pro Asn Pro Asn Lys His Ile Ser Gln Thr Glu Val           
                955                 960                 965               

atc atc cgg ttt gct ttc cag acg tcc atc acg gtg ctg tgc att gcc       3103
Ile Ile Arg Phe Ala Phe Gln Thr Ser Ile Thr Val Leu Cys Ile Ala           
            970                 975                 980                   

tgc ccc tgc tcc ctg ggg ctg gcc acg ccc acg gct gtc atg gtg ggc       3151
Cys Pro Cys Ser Leu Gly Leu Ala Thr Pro Thr Ala Val Met Val Gly           
        985                 990                 995                       

acc ggg  gtg gcc gcg cag aac  ggc atc ctc atc aag  gga ggc aag        3196
Thr Gly  Val Ala Ala Gln Asn  Gly Ile Leu Ile Lys  Gly Gly Lys            
    1000                 1005                 1010                        

ccc ctg  gag atg gcg cac aag  ata aag act gtg atg  ttt gac aag        3241
Pro Leu  Glu Met Ala His Lys  Ile Lys Thr Val Met  Phe Asp Lys            
    1015                 1020                 1025                        

act ggc  acc att acc cat ggc  gtc ccc agg gtc atg  cgg gtg ctc        3286
Thr Gly  Thr Ile Thr His Gly  Val Pro Arg Val Met  Arg Val Leu            
    1030                 1035                 1040                        

ctg ctg  ggg gat gtg gcc aca  ctg ccc ctc agg aag  gtt ctg gct        3331
Leu Leu  Gly Asp Val Ala Thr  Leu Pro Leu Arg Lys  Val Leu Ala            
    1045                 1050                 1055                        

gtg gtg  ggg act gcg gag gcc  agc agt gaa cac ccc  ttg ggc gtg        3376
Val Val  Gly Thr Ala Glu Ala  Ser Ser Glu His Pro  Leu Gly Val            
    1060                 1065                 1070                        

gca gtc  acc aaa tac tgt aaa  gag gaa ctt gga aca  gag acc ttg        3421
Ala Val  Thr Lys Tyr Cys Lys  Glu Glu Leu Gly Thr  Glu Thr Leu            
    1075                 1080                 1085                        

gga tac  tgc acg gac ttc cag  gca gtg cca ggc tgt  gga att ggg        3466
Gly Tyr  Cys Thr Asp Phe Gln  Ala Val Pro Gly Cys  Gly Ile Gly            
    1090                 1095                 1100                        

tgc aaa  gtc agc aac gtg gaa  ggc atc ctg gcc cac  agt gag cgc        3511
Cys Lys  Val Ser Asn Val Glu  Gly Ile Leu Ala His  Ser Glu Arg            
    1105                 1110                 1115                        

cct ttg  agt gca ccg gcc agt  cac ctg aat gag gct  ggc agc ctt        3556
Pro Leu  Ser Ala Pro Ala Ser  His Leu Asn Glu Ala  Gly Ser Leu            
    1120                 1125                 1130                        

ccc gca  gaa aaa gat gca gtc  ccc cag acc ttc tct  gtg ctg att        3601
Pro Ala  Glu Lys Asp Ala Val  Pro Gln Thr Phe Ser  Val Leu Ile            
    1135                 1140                 1145                        

gga aac  cgt gag tgg ctg agg  cgc aac ggt tta acc  att tct agc        3646
Gly Asn  Arg Glu Trp Leu Arg  Arg Asn Gly Leu Thr  Ile Ser Ser            
    1150                 1155                 1160                        

gat gtc  agt gac gct atg aca  gac cac gag atg aaa  gga cag aca        3691
Asp Val  Ser Asp Ala Met Thr  Asp His Glu Met Lys  Gly Gln Thr            
    1165                 1170                 1175                        

gcc atc  ctg gtg gct att gac  ggt gtg ctc tgt ggg  atg atc gca        3736
Ala Ile  Leu Val Ala Ile Asp  Gly Val Leu Cys Gly  Met Ile Ala            
    1180                 1185                 1190                        

atc gca  gac gct gtc aag cag  gag gct gcc ctg gct  gtg cac acg        3781
Ile Ala  Asp Ala Val Lys Gln  Glu Ala Ala Leu Ala  Val His Thr            
    1195                 1200                 1205                        

ctg cag  agc atg ggt gtg gac  gtg gtt ctg atc acg  ggg gac aac        3826
Leu Gln  Ser Met Gly Val Asp  Val Val Leu Ile Thr  Gly Asp Asn            
    1210                 1215                 1220                        

cgg aag  aca gcc aga gct att  gcc acc cag gtt ggc  atc aac aaa        3871
Arg Lys  Thr Ala Arg Ala Ile  Ala Thr Gln Val Gly  Ile Asn Lys            
    1225                 1230                 1235                        

gtc ttt  gca gag gtg ctg cct  tcg cac aag gtg gcc  aag gtc cag        3916
Val Phe  Ala Glu Val Leu Pro  Ser His Lys Val Ala  Lys Val Gln            
    1240                 1245                 1250                        

gag ctc  cag aat aaa ggg aag  aaa gtc gcc atg gtg  ggg gat ggg        3961
Glu Leu  Gln Asn Lys Gly Lys  Lys Val Ala Met Val  Gly Asp Gly            
    1255                 1260                 1265                        

gtc aat  gac tcc ccg gcc ttg  gcc cag gca gac atg  ggt gtg gcc        4006
Val Asn  Asp Ser Pro Ala Leu  Ala Gln Ala Asp Met  Gly Val Ala            
    1270                 1275                 1280                        

att ggc  acc ggc acg gat gtg  gcc atc gag gca gcc  gac gtc gtc        4051
Ile Gly  Thr Gly Thr Asp Val  Ala Ile Glu Ala Ala  Asp Val Val            
    1285                 1290                 1295                        

ctt atc  aga aat gat ttg ctg  gat gtg gtg gct agc  att cac ctt        4096
Leu Ile  Arg Asn Asp Leu Leu  Asp Val Val Ala Ser  Ile His Leu            
    1300                 1305                 1310                        

tcc aag  agg act gtc cga agg  ata cgc atc aac ctg  gtc ctg gca        4141
Ser Lys  Arg Thr Val Arg Arg  Ile Arg Ile Asn Leu  Val Leu Ala            
    1315                 1320                 1325                        

ctg att  tat aac ctg gtt ggg  ata ccc att gca gca  ggt gtc ttc        4186
Leu Ile  Tyr Asn Leu Val Gly  Ile Pro Ile Ala Ala  Gly Val Phe            
    1330                 1335                 1340                        

atg ccc  atc ggc att gtg ctg  cag ccc tgg atg ggc  tca gcg gcc        4231
Met Pro  Ile Gly Ile Val Leu  Gln Pro Trp Met Gly  Ser Ala Ala            
    1345                 1350                 1355                        

atg gca  gcc tcc tct gtg tct  gtg gtg ctc tca tcc  ctg cag ctc        4276
Met Ala  Ala Ser Ser Val Ser  Val Val Leu Ser Ser  Leu Gln Leu            
    1360                 1365                 1370                        

aag tgc  tat aag aag cct gac  ctg gag agg tat gag  gca cag gcg        4321
Lys Cys  Tyr Lys Lys Pro Asp  Leu Glu Arg Tyr Glu  Ala Gln Ala            
    1375                 1380                 1385                        

cat ggc  cac atg aag ccc ctg  acg gca tcc cag gtc  agt gtg cac        4366
His Gly  His Met Lys Pro Leu  Thr Ala Ser Gln Val  Ser Val His            
    1390                 1395                 1400                        

ata ggc  atg gat gac agg tgg  cgg gac tcc ccc agg  gcc aca cca        4411
Ile Gly  Met Asp Asp Arg Trp  Arg Asp Ser Pro Arg  Ala Thr Pro            
    1405                 1410                 1415                        

tgg gac  cag gtc agc tat gtc  agc cag gtg tcg ctg  tcc tcc ctg        4456
Trp Asp  Gln Val Ser Tyr Val  Ser Gln Val Ser Leu  Ser Ser Leu            
    1420                 1425                 1430                        

acg tcc  gac aag cca tct cgg  cac agc gct gca gca  gac gat gat        4501
Thr Ser  Asp Lys Pro Ser Arg  His Ser Ala Ala Ala  Asp Asp Asp            
    1435                 1440                 1445                        

ggg gac  aag tgg tct ctg ctc  ctg aat ggc agg gat  gag gag cag        4546
Gly Asp  Lys Trp Ser Leu Leu  Leu Asn Gly Arg Asp  Glu Glu Gln            
    1450                 1455                 1460                        

tac atc  tga tgacttcagg caggcgggcc ggggcaggga cttgcctcca              4595
Tyr Ile                                                                   
    1465                                                                  

ctcaccacaa gctgagcagg acagccagca gcaggatggg ctgagctagc ctccagcttt     4655

ggggacttcc gctccctgga tatgtccagt catcctgccc tgcagcacgc ggccttgtct     4715

gggtgcagct gggcttggcc tggagaggac ggccctgcct gcctcttggc ctcacgggac     4775

cgtcagcatg ggctttgtct tggactctag tccttggctg gactgtagaa ggtgagaggc     4835

gagtcaccct cctcacagac ctctgcttgg agtatttagg atgactgctg tgaaatggag     4895

aacagtttca tcaggaccaa aaaacctcac tgggcctttc cagagaactg cagacctcac     4955

tgtcagggtc tttctgatga cgcctgtctg tgtgcatcat gtttctgaga ccacagttta     5015

cctcaggtgt gcctgttgct ttcttcctgc atagtctgtt cctttcttcg tacatagtct     5075

gttccttttc tctcctgtgt gcttgtcagt ggggacccct cgcaaccctg cctgtcacct     5135

gggagggtgg gaccaatgtc cttgtggtct ttgctgctgc tctcaggcgc ttctccaatg     5195

ctctggagtg tgcatttcag cttgaacctg cttcctggct cacacatccc cagccaggga     5255

gcttgccaca ctcttcttca agttgaggag agttcttttt tgcttaaagc ccccttctcc     5315

atggagtgtt ggcttctcaa tagagtgttg ttgctgacca gctggagtga gggcctcaga     5375

gcctgacctg agagtccgta ctcggcttcc tgtggggtgt aggttctcgc gattcaggac     5435

gtccttccat atccctgccc agcctgtggt gcttgaaacg tttgccccat gggaaacgta     5495

tgtgtgcagg agcctccctg cacggcccaa ggggcttcgt tttcagtctt ctgactgtca     5555

cctcgtgggg ttcagtagag aattcatgtg actagcgcct ggccttgtgt ggcttggagg     5615

aaatggtact gcccaaatag gaggaaaaca cagcctccct gagcctgcat tctgcacgct     5675

gcccaggggc ttcagaaaag gagtggccac agcaccccga agggagcatc tgtttacctg     5735

gcagtggctc tcagagcagc agaacgggtt cagttttaga ctctgaagtt ggttgtgatt     5795

gacagaaccc tttgggagca aactagtaga gttggattaa attctgggtg aaaccctttt     5855

ctcccacaca aaatagtttt agtgattttt ttcattgtcc attacttgcc aggggcagtt     5915

ttagcagcac ttttgataga ttacgtctaa tcctcccaac caaccagcag ggtagctatt     5975

actgtccaca ttttacaggc aaggaaacag gctccaagag gctgaggact ttgcccagga     6035

tgacatagcc aatggacaag cagtgtctgt cagctgtgaa ggcttcactc ttattgtcct     6095

tctaccttga atagaagttt tcctgataag aataaacgag gaaaaggtcc ttgcctcctg     6155

gaagaacaaa tctaccaggt gatctattca ttgtttcaac tcagaatgca cttgattcag     6215

gaggtcatct gaccttcacc ttggatggtt agtttcactt tttacatata gtttttgcag     6275

ggttttattt tataaaatcc aagcgcgctg ttgattgtgt tttccttgtt ttcagccccc     6335

ccactccagc ccgcagcaca tttccgctgt ccgtcagtaa ttgtgtcctc tctttatgct     6395

tgcttgggga atgttgtttt ctgactaggc tgatcattat ctaaagaatc taattctgtt     6455

gatttttaaa acttttagga ccataaacgt tgtgttcata tatggacatg gaaatattta     6515

tataatttta tagaaaataa ccttttagat ggtcaaagtg taaggagttt ttttgtcaga     6575

taatcatttc tacttcaaaa acatttcatg caatattaga ataaagttcc tgtcattcct     6635

ctaaaaaaa                                                             6644


<210>  436
<211>  1465
<212>  PRT
<213>  Homo sapiens

<400>  436

Met Pro Glu Gln Glu Arg Gln Ile Thr Ala Arg Glu Gly Ala Ser Arg 
1               5                   10                  15      


Lys Ile Leu Ser Lys Leu Ser Leu Pro Thr Arg Ala Trp Glu Pro Ala 
            20                  25                  30          


Met Lys Lys Ser Phe Ala Phe Asp Asn Val Gly Tyr Glu Gly Gly Leu 
        35                  40                  45              


Asp Gly Leu Gly Pro Ser Ser Gln Val Ala Thr Ser Thr Val Arg Ile 
    50                  55                  60                  


Leu Gly Met Thr Cys Gln Ser Cys Val Lys Ser Ile Glu Asp Arg Ile 
65                  70                  75                  80  


Ser Asn Leu Lys Gly Ile Ile Ser Met Lys Val Ser Leu Glu Gln Gly 
                85                  90                  95      


Ser Ala Thr Val Lys Tyr Val Pro Ser Val Val Cys Leu Gln Gln Val 
            100                 105                 110         


Cys His Gln Ile Gly Asp Met Gly Phe Glu Ala Ser Ile Ala Glu Gly 
        115                 120                 125             


Lys Ala Ala Ser Trp Pro Ser Arg Ser Leu Pro Ala Gln Glu Ala Val 
    130                 135                 140                 


Val Lys Leu Arg Val Glu Gly Met Thr Cys Gln Ser Cys Val Ser Ser 
145                 150                 155                 160 


Ile Glu Gly Lys Val Arg Lys Leu Gln Gly Val Val Arg Val Lys Val 
                165                 170                 175     


Ser Leu Ser Asn Gln Glu Ala Val Ile Thr Tyr Gln Pro Tyr Leu Ile 
            180                 185                 190         


Gln Pro Glu Asp Leu Arg Asp His Val Asn Asp Met Gly Phe Glu Ala 
        195                 200                 205             


Ala Ile Lys Ser Lys Val Ala Pro Leu Ser Leu Gly Pro Ile Asp Ile 
    210                 215                 220                 


Glu Arg Leu Gln Ser Thr Asn Pro Lys Arg Pro Leu Ser Ser Ala Asn 
225                 230                 235                 240 


Gln Asn Phe Asn Asn Ser Glu Thr Leu Gly His Gln Gly Ser His Val 
                245                 250                 255     


Val Thr Leu Gln Leu Arg Ile Asp Gly Met His Cys Lys Ser Cys Val 
            260                 265                 270         


Leu Asn Ile Glu Glu Asn Ile Gly Gln Leu Leu Gly Val Gln Ser Ile 
        275                 280                 285             


Gln Val Ser Leu Glu Asn Lys Thr Ala Gln Val Lys Tyr Asp Pro Ser 
    290                 295                 300                 


Cys Thr Ser Pro Val Ala Leu Gln Arg Ala Ile Glu Ala Leu Pro Pro 
305                 310                 315                 320 


Gly Asn Phe Lys Val Ser Leu Pro Asp Gly Ala Glu Gly Ser Gly Thr 
                325                 330                 335     


Asp His Arg Ser Ser Ser Ser His Ser Pro Gly Ser Pro Pro Arg Asn 
            340                 345                 350         


Gln Val Gln Gly Thr Cys Ser Thr Thr Leu Ile Ala Ile Ala Gly Met 
        355                 360                 365             


Thr Cys Ala Ser Cys Val His Ser Ile Glu Gly Met Ile Ser Gln Leu 
    370                 375                 380                 


Glu Gly Val Gln Gln Ile Ser Val Ser Leu Ala Glu Gly Thr Ala Thr 
385                 390                 395                 400 


Val Leu Tyr Asn Pro Ser Val Ile Ser Pro Glu Glu Leu Arg Ala Ala 
                405                 410                 415     


Ile Glu Asp Met Gly Phe Glu Ala Ser Val Val Ser Glu Ser Cys Ser 
            420                 425                 430         


Thr Asn Pro Leu Gly Asn His Ser Ala Gly Asn Ser Met Val Gln Thr 
        435                 440                 445             


Thr Asp Gly Thr Pro Thr Ser Val Gln Glu Val Ala Pro His Thr Gly 
    450                 455                 460                 


Arg Leu Pro Ala Asn His Ala Pro Asp Ile Leu Ala Lys Ser Pro Gln 
465                 470                 475                 480 


Ser Thr Arg Ala Val Ala Pro Gln Lys Cys Phe Leu Gln Ile Lys Gly 
                485                 490                 495     


Met Thr Cys Ala Ser Cys Val Ser Asn Ile Glu Arg Asn Leu Gln Lys 
            500                 505                 510         


Glu Ala Gly Val Leu Ser Val Leu Val Ala Leu Met Ala Gly Lys Ala 
        515                 520                 525             


Glu Ile Lys Tyr Asp Pro Glu Val Ile Gln Pro Leu Glu Ile Ala Gln 
    530                 535                 540                 


Phe Ile Gln Asp Leu Gly Phe Glu Ala Ala Val Met Glu Asp Tyr Ala 
545                 550                 555                 560 


Gly Ser Asp Gly Asn Ile Glu Leu Thr Ile Thr Gly Met Thr Cys Ala 
                565                 570                 575     


Ser Cys Val His Asn Ile Glu Ser Lys Leu Thr Arg Thr Asn Gly Ile 
            580                 585                 590         


Thr Tyr Ala Ser Val Ala Leu Ala Thr Ser Lys Ala Leu Val Lys Phe 
        595                 600                 605             


Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile Lys Ile Ile Glu Glu 
    610                 615                 620                 


Ile Gly Phe His Ala Ser Leu Ala Gln Arg Asn Pro Asn Ala His His 
625                 630                 635                 640 


Leu Asp His Lys Met Glu Ile Lys Gln Trp Lys Lys Ser Phe Leu Cys 
                645                 650                 655     


Ser Leu Val Phe Gly Ile Pro Val Met Ala Leu Met Ile Tyr Met Leu 
            660                 665                 670         


Ile Pro Ser Asn Glu Pro His Gln Ser Met Val Leu Asp His Asn Ile 
        675                 680                 685             


Ile Pro Gly Leu Ser Ile Leu Asn Leu Ile Phe Phe Ile Leu Cys Thr 
    690                 695                 700                 


Phe Val Gln Leu Leu Gly Gly Trp Tyr Phe Tyr Val Gln Ala Tyr Lys 
705                 710                 715                 720 


Ser Leu Arg His Arg Ser Ala Asn Met Asp Val Leu Ile Val Leu Ala 
                725                 730                 735     


Thr Ser Ile Ala Tyr Val Tyr Ser Leu Val Ile Leu Val Val Ala Val 
            740                 745                 750         


Ala Glu Lys Ala Glu Arg Ser Pro Val Thr Phe Phe Asp Thr Pro Pro 
        755                 760                 765             


Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Leu Ala 
    770                 775                 780                 


Lys Ser Lys Thr Ser Glu Ala Leu Ala Lys Leu Met Ser Leu Gln Ala 
785                 790                 795                 800 


Thr Glu Ala Thr Val Val Thr Leu Gly Glu Asp Asn Leu Ile Ile Arg 
                805                 810                 815     


Glu Glu Gln Val Pro Met Glu Leu Val Gln Arg Gly Asp Ile Val Lys 
            820                 825                 830         


Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Lys Val Leu Glu Gly 
        835                 840                 845             


Asn Thr Met Ala Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro Val 
    850                 855                 860                 


Thr Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Ala His 
865                 870                 875                 880 


Gly Ser Val Leu Ile Lys Ala Thr His Val Gly Asn Asp Thr Thr Leu 
                885                 890                 895     


Ala Gln Ile Val Lys Leu Val Glu Glu Ala Gln Met Ser Lys Ala Pro 
            900                 905                 910         


Ile Gln Gln Leu Ala Asp Arg Phe Ser Gly Tyr Phe Val Pro Phe Ile 
        915                 920                 925             


Ile Ile Met Ser Thr Leu Thr Leu Val Val Trp Ile Val Ile Gly Phe 
    930                 935                 940                 


Ile Asp Phe Gly Val Val Gln Arg Tyr Phe Pro Asn Pro Asn Lys His 
945                 950                 955                 960 


Ile Ser Gln Thr Glu Val Ile Ile Arg Phe Ala Phe Gln Thr Ser Ile 
                965                 970                 975     


Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala Thr Pro 
            980                 985                 990         


Thr Ala Val Met Val Gly Thr Gly  Val Ala Ala Gln Asn  Gly Ile Leu 
        995                 1000                 1005             


Ile Lys  Gly Gly Lys Pro Leu  Glu Met Ala His Lys  Ile Lys Thr 
    1010                 1015                 1020             


Val Met  Phe Asp Lys Thr Gly  Thr Ile Thr His Gly  Val Pro Arg 
    1025                 1030                 1035             


Val Met  Arg Val Leu Leu Leu  Gly Asp Val Ala Thr  Leu Pro Leu 
    1040                 1045                 1050             


Arg Lys  Val Leu Ala Val Val  Gly Thr Ala Glu Ala  Ser Ser Glu 
    1055                 1060                 1065             


His Pro  Leu Gly Val Ala Val  Thr Lys Tyr Cys Lys  Glu Glu Leu 
    1070                 1075                 1080             


Gly Thr  Glu Thr Leu Gly Tyr  Cys Thr Asp Phe Gln  Ala Val Pro 
    1085                 1090                 1095             


Gly Cys  Gly Ile Gly Cys Lys  Val Ser Asn Val Glu  Gly Ile Leu 
    1100                 1105                 1110             


Ala His  Ser Glu Arg Pro Leu  Ser Ala Pro Ala Ser  His Leu Asn 
    1115                 1120                 1125             


Glu Ala  Gly Ser Leu Pro Ala  Glu Lys Asp Ala Val  Pro Gln Thr 
    1130                 1135                 1140             


Phe Ser  Val Leu Ile Gly Asn  Arg Glu Trp Leu Arg  Arg Asn Gly 
    1145                 1150                 1155             


Leu Thr  Ile Ser Ser Asp Val  Ser Asp Ala Met Thr  Asp His Glu 
    1160                 1165                 1170             


Met Lys  Gly Gln Thr Ala Ile  Leu Val Ala Ile Asp  Gly Val Leu 
    1175                 1180                 1185             


Cys Gly  Met Ile Ala Ile Ala  Asp Ala Val Lys Gln  Glu Ala Ala 
    1190                 1195                 1200             


Leu Ala  Val His Thr Leu Gln  Ser Met Gly Val Asp  Val Val Leu 
    1205                 1210                 1215             


Ile Thr  Gly Asp Asn Arg Lys  Thr Ala Arg Ala Ile  Ala Thr Gln 
    1220                 1225                 1230             


Val Gly  Ile Asn Lys Val Phe  Ala Glu Val Leu Pro  Ser His Lys 
    1235                 1240                 1245             


Val Ala  Lys Val Gln Glu Leu  Gln Asn Lys Gly Lys  Lys Val Ala 
    1250                 1255                 1260             


Met Val  Gly Asp Gly Val Asn  Asp Ser Pro Ala Leu  Ala Gln Ala 
    1265                 1270                 1275             


Asp Met  Gly Val Ala Ile Gly  Thr Gly Thr Asp Val  Ala Ile Glu 
    1280                 1285                 1290             


Ala Ala  Asp Val Val Leu Ile  Arg Asn Asp Leu Leu  Asp Val Val 
    1295                 1300                 1305             


Ala Ser  Ile His Leu Ser Lys  Arg Thr Val Arg Arg  Ile Arg Ile 
    1310                 1315                 1320             


Asn Leu  Val Leu Ala Leu Ile  Tyr Asn Leu Val Gly  Ile Pro Ile 
    1325                 1330                 1335             


Ala Ala  Gly Val Phe Met Pro  Ile Gly Ile Val Leu  Gln Pro Trp 
    1340                 1345                 1350             


Met Gly  Ser Ala Ala Met Ala  Ala Ser Ser Val Ser  Val Val Leu 
    1355                 1360                 1365             


Ser Ser  Leu Gln Leu Lys Cys  Tyr Lys Lys Pro Asp  Leu Glu Arg 
    1370                 1375                 1380             


Tyr Glu  Ala Gln Ala His Gly  His Met Lys Pro Leu  Thr Ala Ser 
    1385                 1390                 1395             


Gln Val  Ser Val His Ile Gly  Met Asp Asp Arg Trp  Arg Asp Ser 
    1400                 1405                 1410             


Pro Arg  Ala Thr Pro Trp Asp  Gln Val Ser Tyr Val  Ser Gln Val 
    1415                 1420                 1425             


Ser Leu  Ser Ser Leu Thr Ser  Asp Lys Pro Ser Arg  His Ser Ala 
    1430                 1435                 1440             


Ala Ala  Asp Asp Asp Gly Asp  Lys Trp Ser Leu Leu  Leu Asn Gly 
    1445                 1450                 1455             


Arg Asp  Glu Glu Gln Tyr Ile  
    1460                 1465 


<210>  437
<211>  1177
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (179)..(862)

<400>  437
gtgcgtcgta gccgaacgct gtggcggggc aggcgaggcg gtcgcttcga gcgcgctagt       60

cagctccctg aagggagtga cggcggttgg gtgcccgcgg ccacttttgc cttcccgggg      120

agatgtcctt tgcttctcag atgtaaatgc actttaagtt tgttattcaa cagtgaaa        178

atg agt cat aca gag gtt aaa tta aaa ata cct ttt gga aat aaa tta        226
Met Ser His Thr Glu Val Lys Leu Lys Ile Pro Phe Gly Asn Lys Leu           
1               5                   10                  15                

cta gat gct gtt tgt ttg gta cct aac aag agc tta aca tat gga ata        274
Leu Asp Ala Val Cys Leu Val Pro Asn Lys Ser Leu Thr Tyr Gly Ile           
            20                  25                  30                    

att ctt aca cat gga gca tca gga gat atg aat ctt cct cat ttg atg        322
Ile Leu Thr His Gly Ala Ser Gly Asp Met Asn Leu Pro His Leu Met           
        35                  40                  45                        

tca ctg gca tcc cat ctt gca tct cat ggg ttt ttc tgc ctg aga ttt        370
Ser Leu Ala Ser His Leu Ala Ser His Gly Phe Phe Cys Leu Arg Phe           
    50                  55                  60                            

acc tgt aaa ggc ctt aat att gta cat aga att aag gcg tat aaa tca        418
Thr Cys Lys Gly Leu Asn Ile Val His Arg Ile Lys Ala Tyr Lys Ser           
65                  70                  75                  80            

gtt ttg aat tac ctg aag aca tca gga gaa tac aaa ctt gca ggt gtt        466
Val Leu Asn Tyr Leu Lys Thr Ser Gly Glu Tyr Lys Leu Ala Gly Val           
                85                  90                  95                

ttt ctt gga ggt cgt tca atg ggc tca aga gca gct gct tct gta atg        514
Phe Leu Gly Gly Arg Ser Met Gly Ser Arg Ala Ala Ala Ser Val Met           
            100                 105                 110                   

tgt cac att gag cca gat gat ggt gat gat ttt gtt cgg ggt ctc att        562
Cys His Ile Glu Pro Asp Asp Gly Asp Asp Phe Val Arg Gly Leu Ile           
        115                 120                 125                       

tgt att tct tac cca ctg cac cat cca aag cag cag cat aaa ctc aga        610
Cys Ile Ser Tyr Pro Leu His His Pro Lys Gln Gln His Lys Leu Arg           
    130                 135                 140                           

gat gaa gac ctc ttt cgt tta aaa gag cct gta ctg ttt gtg tca ggc        658
Asp Glu Asp Leu Phe Arg Leu Lys Glu Pro Val Leu Phe Val Ser Gly           
145                 150                 155                 160           

tca gca gat gaa atg tgt gaa aag aac ttg ttg gag aaa gtg gca cag        706
Ser Ala Asp Glu Met Cys Glu Lys Asn Leu Leu Glu Lys Val Ala Gln           
                165                 170                 175               

aaa atg caa gct ccc cat aaa atc cac tgg att gag aag gca aat cat        754
Lys Met Gln Ala Pro His Lys Ile His Trp Ile Glu Lys Ala Asn His           
            180                 185                 190                   

tcc atg gca gtg aaa gga cgg tcg aca aat gat gtt ttc aaa gaa ata        802
Ser Met Ala Val Lys Gly Arg Ser Thr Asn Asp Val Phe Lys Glu Ile           
        195                 200                 205                       

aat aca cag att ttg ttt tgg atc caa gaa att act gaa atg gac aag        850
Asn Thr Gln Ile Leu Phe Trp Ile Gln Glu Ile Thr Glu Met Asp Lys           
    210                 215                 220                           

aaa tgt cat tag ttaaaagcca tgttatcttg agtacacata cagttaattt            902
Lys Cys His                                                               
225                                                                       

gataaagaag agtatgcctc tcagcattgt gagatatatt tcagactaat ttgatgttct      962

ttaatgttcc cttatttttg aaacacgttt taaatgtgaa attaatgtcc ttcacaaaat     1022

gtcttttgaa agcactgtta cagttgtata aagatgatgt aaaaatattg aaggtggtct     1082

acatataatt tattttcatt agtatagtta agttttgaaa aaaattaaac atctgaattt     1142

tgttacaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                1177


<210>  438
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  438

Met Ser His Thr Glu Val Lys Leu Lys Ile Pro Phe Gly Asn Lys Leu 
1               5                   10                  15      


Leu Asp Ala Val Cys Leu Val Pro Asn Lys Ser Leu Thr Tyr Gly Ile 
            20                  25                  30          


Ile Leu Thr His Gly Ala Ser Gly Asp Met Asn Leu Pro His Leu Met 
        35                  40                  45              


Ser Leu Ala Ser His Leu Ala Ser His Gly Phe Phe Cys Leu Arg Phe 
    50                  55                  60                  


Thr Cys Lys Gly Leu Asn Ile Val His Arg Ile Lys Ala Tyr Lys Ser 
65                  70                  75                  80  


Val Leu Asn Tyr Leu Lys Thr Ser Gly Glu Tyr Lys Leu Ala Gly Val 
                85                  90                  95      


Phe Leu Gly Gly Arg Ser Met Gly Ser Arg Ala Ala Ala Ser Val Met 
            100                 105                 110         


Cys His Ile Glu Pro Asp Asp Gly Asp Asp Phe Val Arg Gly Leu Ile 
        115                 120                 125             


Cys Ile Ser Tyr Pro Leu His His Pro Lys Gln Gln His Lys Leu Arg 
    130                 135                 140                 


Asp Glu Asp Leu Phe Arg Leu Lys Glu Pro Val Leu Phe Val Ser Gly 
145                 150                 155                 160 


Ser Ala Asp Glu Met Cys Glu Lys Asn Leu Leu Glu Lys Val Ala Gln 
                165                 170                 175     


Lys Met Gln Ala Pro His Lys Ile His Trp Ile Glu Lys Ala Asn His 
            180                 185                 190         


Ser Met Ala Val Lys Gly Arg Ser Thr Asn Asp Val Phe Lys Glu Ile 
        195                 200                 205             


Asn Thr Gln Ile Leu Phe Trp Ile Gln Glu Ile Thr Glu Met Asp Lys 
    210                 215                 220                 


Lys Cys His 
225         


<210>  439
<211>  2589
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (24)..(2510)

<400>  439
gacggacggg gtcaggtccc atc atg gcg gct gaa gag gcg gat gtg gat atc       53
                          Met Ala Ala Glu Glu Ala Asp Val Asp Ile         
                          1               5                   10          

gaa ggg gac gtg gta gcg gcg gcg ggg gca cag cca gga agt ggt gaa        101
Glu Gly Asp Val Val Ala Ala Ala Gly Ala Gln Pro Gly Ser Gly Glu           
                15                  20                  25                

aat aca gca tca gtt tta caa aaa gat cac tat ctt gat tca tct tgg        149
Asn Thr Ala Ser Val Leu Gln Lys Asp His Tyr Leu Asp Ser Ser Trp           
            30                  35                  40                    

aga aca gag aat ggc ctt att cct tgg acc ttg gat aac acc atc agt        197
Arg Thr Glu Asn Gly Leu Ile Pro Trp Thr Leu Asp Asn Thr Ile Ser           
        45                  50                  55                        

gaa gag aac aga gct gtt att gag aaa atg ttg ttg gaa gaa gaa tat        245
Glu Glu Asn Arg Ala Val Ile Glu Lys Met Leu Leu Glu Glu Glu Tyr           
    60                  65                  70                            

tat tta tct aaa aaa tca caa ccg gaa aaa gtc tgg ctt gat caa aag        293
Tyr Leu Ser Lys Lys Ser Gln Pro Glu Lys Val Trp Leu Asp Gln Lys           
75                  80                  85                  90            

gaa gat gat aaa aaa tac atg aag agt ctg cag aaa aca gca aaa atc        341
Glu Asp Asp Lys Lys Tyr Met Lys Ser Leu Gln Lys Thr Ala Lys Ile           
                95                  100                 105               

atg gta cac tct cct aca aaa cca gcc agt tac tca gta aag tgg acg        389
Met Val His Ser Pro Thr Lys Pro Ala Ser Tyr Ser Val Lys Trp Thr           
            110                 115                 120                   

ata gaa gaa aaa gag ctg ttt gaa caa ggg ctg gct aaa ttt ggc cga        437
Ile Glu Glu Lys Glu Leu Phe Glu Gln Gly Leu Ala Lys Phe Gly Arg           
        125                 130                 135                       

aga tgg acc aaa att tca aag cta att gga agc cgc act gtt tta caa        485
Arg Trp Thr Lys Ile Ser Lys Leu Ile Gly Ser Arg Thr Val Leu Gln           
    140                 145                 150                           

gtg aag agt tat gca aga cag tat ttt aaa aat aag gtc aaa tgc ggt        533
Val Lys Ser Tyr Ala Arg Gln Tyr Phe Lys Asn Lys Val Lys Cys Gly           
155                 160                 165                 170           

ctg gat aaa gaa aca cca aat cag aag acc ggc cat aat ctt caa gtt        581
Leu Asp Lys Glu Thr Pro Asn Gln Lys Thr Gly His Asn Leu Gln Val           
                175                 180                 185               

aaa aat gaa gat aaa ggg aca aag gca tgg aca cca tca tgt tta agg        629
Lys Asn Glu Asp Lys Gly Thr Lys Ala Trp Thr Pro Ser Cys Leu Arg           
            190                 195                 200                   

gga cgt gct gat ccc aac ttg aat gct gta aaa att gaa aag tta tct        677
Gly Arg Ala Asp Pro Asn Leu Asn Ala Val Lys Ile Glu Lys Leu Ser           
        205                 210                 215                       

gat gat gaa gaa gta gac atc aca gat gag gtg gac gag ttg tct tct        725
Asp Asp Glu Glu Val Asp Ile Thr Asp Glu Val Asp Glu Leu Ser Ser           
    220                 225                 230                           

caa aca ccc cag aag aat tct agc agt gat ctc ttg tta gac ttt cct        773
Gln Thr Pro Gln Lys Asn Ser Ser Ser Asp Leu Leu Leu Asp Phe Pro           
235                 240                 245                 250           

aat agt aaa atg cat gaa acc aat caa gga gaa ttc att act tct gac        821
Asn Ser Lys Met His Glu Thr Asn Gln Gly Glu Phe Ile Thr Ser Asp           
                255                 260                 265               

agc cag gaa gct ctc ttt tct aag tct tcc agg ggc tgt ctt caa aat        869
Ser Gln Glu Ala Leu Phe Ser Lys Ser Ser Arg Gly Cys Leu Gln Asn           
            270                 275                 280                   

gaa aag caa gat gaa aca ctt tca agc tca gaa att aca ctg tgg act        917
Glu Lys Gln Asp Glu Thr Leu Ser Ser Ser Glu Ile Thr Leu Trp Thr           
        285                 290                 295                       

gag aaa cag agc aat ggt gac aaa aaa tca att gaa tta aat gac cag        965
Glu Lys Gln Ser Asn Gly Asp Lys Lys Ser Ile Glu Leu Asn Asp Gln           
    300                 305                 310                           

aaa ttt aat gaa ttg att aaa aac tgc aac aag cat gat gga agg gga       1013
Lys Phe Asn Glu Leu Ile Lys Asn Cys Asn Lys His Asp Gly Arg Gly           
315                 320                 325                 330           

ata ata gtt gat gcc agg cag ttg cct tct cca gag cct tgt gaa att       1061
Ile Ile Val Asp Ala Arg Gln Leu Pro Ser Pro Glu Pro Cys Glu Ile           
                335                 340                 345               

cag aaa aat ttg aat gat aat gaa atg ctt ttt cat tct tgc caa atg       1109
Gln Lys Asn Leu Asn Asp Asn Glu Met Leu Phe His Ser Cys Gln Met           
            350                 355                 360                   

gta gag gaa agc cat gag gaa gaa gag ctt aag cca cca gaa cag gaa       1157
Val Glu Glu Ser His Glu Glu Glu Glu Leu Lys Pro Pro Glu Gln Glu           
        365                 370                 375                       

ata gaa ata gat aga aat atc att caa gaa gaa gaa aaa caa gca att       1205
Ile Glu Ile Asp Arg Asn Ile Ile Gln Glu Glu Glu Lys Gln Ala Ile           
    380                 385                 390                           

cct gag ttt ttt gag ggg cgc caa gct aaa aca cca gaa cgc tat ttg       1253
Pro Glu Phe Phe Glu Gly Arg Gln Ala Lys Thr Pro Glu Arg Tyr Leu           
395                 400                 405                 410           

aaa att aga aat tat att ttg gat caa tgg gag ata tgc aaa cca aaa       1301
Lys Ile Arg Asn Tyr Ile Leu Asp Gln Trp Glu Ile Cys Lys Pro Lys           
                415                 420                 425               

tac tta aat aag acc tca gta cgt cct ggc ctg aag aac tgt gga gat       1349
Tyr Leu Asn Lys Thr Ser Val Arg Pro Gly Leu Lys Asn Cys Gly Asp           
            430                 435                 440                   

gtt aat tgt att gga cgg att cat aca tac ctc gaa ttg ata gga gca       1397
Val Asn Cys Ile Gly Arg Ile His Thr Tyr Leu Glu Leu Ile Gly Ala           
        445                 450                 455                       

atc aat ttt gga tgt gaa cag gct gtg tat aat agg cca caa aca gtt       1445
Ile Asn Phe Gly Cys Glu Gln Ala Val Tyr Asn Arg Pro Gln Thr Val           
    460                 465                 470                           

gac aaa gta cga atc aga gac aga aaa gat gca gta gaa gca tac caa       1493
Asp Lys Val Arg Ile Arg Asp Arg Lys Asp Ala Val Glu Ala Tyr Gln           
475                 480                 485                 490           

ctt gcc cag cgt ctg cag tct atg cgt aca agg aga cgt agg gtc cga       1541
Leu Ala Gln Arg Leu Gln Ser Met Arg Thr Arg Arg Arg Arg Val Arg           
                495                 500                 505               

gac cca tgg gga aac tgg tgt gat gca aag gac tta gaa gga caa acg       1589
Asp Pro Trp Gly Asn Trp Cys Asp Ala Lys Asp Leu Glu Gly Gln Thr           
            510                 515                 520                   

ttt gag cat ctc tct gct gag gag ttg gca aaa aga aga gaa gag gaa       1637
Phe Glu His Leu Ser Ala Glu Glu Leu Ala Lys Arg Arg Glu Glu Glu           
        525                 530                 535                       

aaa ggc aga cct gtt aaa tct tta aaa gtg cca aga cca aca aaa agc       1685
Lys Gly Arg Pro Val Lys Ser Leu Lys Val Pro Arg Pro Thr Lys Ser           
    540                 545                 550                           

tcg ttt gat ccc ttc caa ctg ata cct tgt aat ttt ttt agt gaa gaa       1733
Ser Phe Asp Pro Phe Gln Leu Ile Pro Cys Asn Phe Phe Ser Glu Glu           
555                 560                 565                 570           

aag cag gag cca ttt cag gtg aaa gtg gct tca gaa gca ctt tta ata       1781
Lys Gln Glu Pro Phe Gln Val Lys Val Ala Ser Glu Ala Leu Leu Ile           
                575                 580                 585               

atg gat ttg cat gct cat gtt tct atg gca gaa gtg att ggt ctg tta       1829
Met Asp Leu His Ala His Val Ser Met Ala Glu Val Ile Gly Leu Leu           
            590                 595                 600                   

gga gga aga tac tca gaa gtt gat aaa gta gtt gaa gtc tgt gca gca       1877
Gly Gly Arg Tyr Ser Glu Val Asp Lys Val Val Glu Val Cys Ala Ala           
        605                 610                 615                       

gaa cca tgt aac agt ctg agt aca gga cta cag tgt gag atg gat cct       1925
Glu Pro Cys Asn Ser Leu Ser Thr Gly Leu Gln Cys Glu Met Asp Pro           
    620                 625                 630                           

gta tca caa aca cag gcc tca gaa acc ttg gct gtt aga ggc ttc agt       1973
Val Ser Gln Thr Gln Ala Ser Glu Thr Leu Ala Val Arg Gly Phe Ser           
635                 640                 645                 650           

gtt att gga tgg tat cat tct cat cct gct ttt gat cct aat cct tcc       2021
Val Ile Gly Trp Tyr His Ser His Pro Ala Phe Asp Pro Asn Pro Ser           
                655                 660                 665               

tta cga gat att gac aca caa gct aaa tac cag agt tac ttc tcc aga       2069
Leu Arg Asp Ile Asp Thr Gln Ala Lys Tyr Gln Ser Tyr Phe Ser Arg           
            670                 675                 680                   

gga ggt gca aag ttc att ggg atg att gtt agt ccc tat aat cga aat       2117
Gly Gly Ala Lys Phe Ile Gly Met Ile Val Ser Pro Tyr Asn Arg Asn           
        685                 690                 695                       

aat ccc tta cca tat tct cag att acc tgc ctg gtt ata agt gag gaa       2165
Asn Pro Leu Pro Tyr Ser Gln Ile Thr Cys Leu Val Ile Ser Glu Glu           
    700                 705                 710                           

att agc cca gat ggc tct tat cgc tta cct tac aaa ttt gaa gta cag       2213
Ile Ser Pro Asp Gly Ser Tyr Arg Leu Pro Tyr Lys Phe Glu Val Gln           
715                 720                 725                 730           

cag atg tta gaa gaa cct cag tgg gga tta gta ttt gaa aag aca aga       2261
Gln Met Leu Glu Glu Pro Gln Trp Gly Leu Val Phe Glu Lys Thr Arg           
                735                 740                 745               

tgg ata ata gaa aaa tac agg ctc tcc cat agc agc gtc ccc atg gat       2309
Trp Ile Ile Glu Lys Tyr Arg Leu Ser His Ser Ser Val Pro Met Asp           
            750                 755                 760                   

aaa atc ttt cgc cgg gat tct gac ctg act tgt ttg cag aaa ctt ttg       2357
Lys Ile Phe Arg Arg Asp Ser Asp Leu Thr Cys Leu Gln Lys Leu Leu           
        765                 770                 775                       

gag tgt atg agg aag act ctg agc aaa gtg acc aat tgc ttt atg gct       2405
Glu Cys Met Arg Lys Thr Leu Ser Lys Val Thr Asn Cys Phe Met Ala           
    780                 785                 790                           

gaa gaa ttc ttg act gaa ata gaa aat ttg ttc ctt tcc aat tat aaa       2453
Glu Glu Phe Leu Thr Glu Ile Glu Asn Leu Phe Leu Ser Asn Tyr Lys           
795                 800                 805                 810           

agc aac caa gag aat gga gta acc gaa gag aac tgt aca aag gaa ttg       2501
Ser Asn Gln Glu Asn Gly Val Thr Glu Glu Asn Cys Thr Lys Glu Leu           
                815                 820                 825               

tta atg tga ttattttaaa gttaagacat tttaatcttg acacagtaga               2550
Leu Met                                                                   
                                                                          

tcttactttc aaagttataa acttgaagtg attgtagtt                            2589


<210>  440
<211>  828
<212>  PRT
<213>  Homo sapiens

<400>  440

Met Ala Ala Glu Glu Ala Asp Val Asp Ile Glu Gly Asp Val Val Ala 
1               5                   10                  15      


Ala Ala Gly Ala Gln Pro Gly Ser Gly Glu Asn Thr Ala Ser Val Leu 
            20                  25                  30          


Gln Lys Asp His Tyr Leu Asp Ser Ser Trp Arg Thr Glu Asn Gly Leu 
        35                  40                  45              


Ile Pro Trp Thr Leu Asp Asn Thr Ile Ser Glu Glu Asn Arg Ala Val 
    50                  55                  60                  


Ile Glu Lys Met Leu Leu Glu Glu Glu Tyr Tyr Leu Ser Lys Lys Ser 
65                  70                  75                  80  


Gln Pro Glu Lys Val Trp Leu Asp Gln Lys Glu Asp Asp Lys Lys Tyr 
                85                  90                  95      


Met Lys Ser Leu Gln Lys Thr Ala Lys Ile Met Val His Ser Pro Thr 
            100                 105                 110         


Lys Pro Ala Ser Tyr Ser Val Lys Trp Thr Ile Glu Glu Lys Glu Leu 
        115                 120                 125             


Phe Glu Gln Gly Leu Ala Lys Phe Gly Arg Arg Trp Thr Lys Ile Ser 
    130                 135                 140                 


Lys Leu Ile Gly Ser Arg Thr Val Leu Gln Val Lys Ser Tyr Ala Arg 
145                 150                 155                 160 


Gln Tyr Phe Lys Asn Lys Val Lys Cys Gly Leu Asp Lys Glu Thr Pro 
                165                 170                 175     


Asn Gln Lys Thr Gly His Asn Leu Gln Val Lys Asn Glu Asp Lys Gly 
            180                 185                 190         


Thr Lys Ala Trp Thr Pro Ser Cys Leu Arg Gly Arg Ala Asp Pro Asn 
        195                 200                 205             


Leu Asn Ala Val Lys Ile Glu Lys Leu Ser Asp Asp Glu Glu Val Asp 
    210                 215                 220                 


Ile Thr Asp Glu Val Asp Glu Leu Ser Ser Gln Thr Pro Gln Lys Asn 
225                 230                 235                 240 


Ser Ser Ser Asp Leu Leu Leu Asp Phe Pro Asn Ser Lys Met His Glu 
                245                 250                 255     


Thr Asn Gln Gly Glu Phe Ile Thr Ser Asp Ser Gln Glu Ala Leu Phe 
            260                 265                 270         


Ser Lys Ser Ser Arg Gly Cys Leu Gln Asn Glu Lys Gln Asp Glu Thr 
        275                 280                 285             


Leu Ser Ser Ser Glu Ile Thr Leu Trp Thr Glu Lys Gln Ser Asn Gly 
    290                 295                 300                 


Asp Lys Lys Ser Ile Glu Leu Asn Asp Gln Lys Phe Asn Glu Leu Ile 
305                 310                 315                 320 


Lys Asn Cys Asn Lys His Asp Gly Arg Gly Ile Ile Val Asp Ala Arg 
                325                 330                 335     


Gln Leu Pro Ser Pro Glu Pro Cys Glu Ile Gln Lys Asn Leu Asn Asp 
            340                 345                 350         


Asn Glu Met Leu Phe His Ser Cys Gln Met Val Glu Glu Ser His Glu 
        355                 360                 365             


Glu Glu Glu Leu Lys Pro Pro Glu Gln Glu Ile Glu Ile Asp Arg Asn 
    370                 375                 380                 


Ile Ile Gln Glu Glu Glu Lys Gln Ala Ile Pro Glu Phe Phe Glu Gly 
385                 390                 395                 400 


Arg Gln Ala Lys Thr Pro Glu Arg Tyr Leu Lys Ile Arg Asn Tyr Ile 
                405                 410                 415     


Leu Asp Gln Trp Glu Ile Cys Lys Pro Lys Tyr Leu Asn Lys Thr Ser 
            420                 425                 430         


Val Arg Pro Gly Leu Lys Asn Cys Gly Asp Val Asn Cys Ile Gly Arg 
        435                 440                 445             


Ile His Thr Tyr Leu Glu Leu Ile Gly Ala Ile Asn Phe Gly Cys Glu 
    450                 455                 460                 


Gln Ala Val Tyr Asn Arg Pro Gln Thr Val Asp Lys Val Arg Ile Arg 
465                 470                 475                 480 


Asp Arg Lys Asp Ala Val Glu Ala Tyr Gln Leu Ala Gln Arg Leu Gln 
                485                 490                 495     


Ser Met Arg Thr Arg Arg Arg Arg Val Arg Asp Pro Trp Gly Asn Trp 
            500                 505                 510         


Cys Asp Ala Lys Asp Leu Glu Gly Gln Thr Phe Glu His Leu Ser Ala 
        515                 520                 525             


Glu Glu Leu Ala Lys Arg Arg Glu Glu Glu Lys Gly Arg Pro Val Lys 
    530                 535                 540                 


Ser Leu Lys Val Pro Arg Pro Thr Lys Ser Ser Phe Asp Pro Phe Gln 
545                 550                 555                 560 


Leu Ile Pro Cys Asn Phe Phe Ser Glu Glu Lys Gln Glu Pro Phe Gln 
                565                 570                 575     


Val Lys Val Ala Ser Glu Ala Leu Leu Ile Met Asp Leu His Ala His 
            580                 585                 590         


Val Ser Met Ala Glu Val Ile Gly Leu Leu Gly Gly Arg Tyr Ser Glu 
        595                 600                 605             


Val Asp Lys Val Val Glu Val Cys Ala Ala Glu Pro Cys Asn Ser Leu 
    610                 615                 620                 


Ser Thr Gly Leu Gln Cys Glu Met Asp Pro Val Ser Gln Thr Gln Ala 
625                 630                 635                 640 


Ser Glu Thr Leu Ala Val Arg Gly Phe Ser Val Ile Gly Trp Tyr His 
                645                 650                 655     


Ser His Pro Ala Phe Asp Pro Asn Pro Ser Leu Arg Asp Ile Asp Thr 
            660                 665                 670         


Gln Ala Lys Tyr Gln Ser Tyr Phe Ser Arg Gly Gly Ala Lys Phe Ile 
        675                 680                 685             


Gly Met Ile Val Ser Pro Tyr Asn Arg Asn Asn Pro Leu Pro Tyr Ser 
    690                 695                 700                 


Gln Ile Thr Cys Leu Val Ile Ser Glu Glu Ile Ser Pro Asp Gly Ser 
705                 710                 715                 720 


Tyr Arg Leu Pro Tyr Lys Phe Glu Val Gln Gln Met Leu Glu Glu Pro 
                725                 730                 735     


Gln Trp Gly Leu Val Phe Glu Lys Thr Arg Trp Ile Ile Glu Lys Tyr 
            740                 745                 750         


Arg Leu Ser His Ser Ser Val Pro Met Asp Lys Ile Phe Arg Arg Asp 
        755                 760                 765             


Ser Asp Leu Thr Cys Leu Gln Lys Leu Leu Glu Cys Met Arg Lys Thr 
    770                 775                 780                 


Leu Ser Lys Val Thr Asn Cys Phe Met Ala Glu Glu Phe Leu Thr Glu 
785                 790                 795                 800 


Ile Glu Asn Leu Phe Leu Ser Asn Tyr Lys Ser Asn Gln Glu Asn Gly 
                805                 810                 815     


Val Thr Glu Glu Asn Cys Thr Lys Glu Leu Leu Met 
            820                 825             


<210>  441
<211>  1480
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1404)

<400>  441
tct gga aca tta gac agg atg ctg atc ttc tgg aca atc aca ctt ttc         48
Ser Gly Thr Leu Asp Arg Met Leu Ile Phe Trp Thr Ile Thr Leu Phe           
1               5                   10                  15                

ctg ctg gga gca gcc aaa gga aaa gaa gtt tgc tat gag gac ctc ggg         96
Leu Leu Gly Ala Ala Lys Gly Lys Glu Val Cys Tyr Glu Asp Leu Gly           
            20                  25                  30                    

tgc ttt tct gac act gag ccc tgg ggc ggg aca gca atc agg ccc ctg        144
Cys Phe Ser Asp Thr Glu Pro Trp Gly Gly Thr Ala Ile Arg Pro Leu           
        35                  40                  45                        

aaa att ctc ccc tgg agc cct gag aag atc ggc acc cgc ttc ctg ctg        192
Lys Ile Leu Pro Trp Ser Pro Glu Lys Ile Gly Thr Arg Phe Leu Leu           
    50                  55                  60                            

tac acc aat gaa aac cca aac aac ttt caa att ctc ctc ctc tct gat        240
Tyr Thr Asn Glu Asn Pro Asn Asn Phe Gln Ile Leu Leu Leu Ser Asp           
65                  70                  75                  80            

cca tca aca att gag gca tca aat ttt caa atg gac aga aag acc cgg        288
Pro Ser Thr Ile Glu Ala Ser Asn Phe Gln Met Asp Arg Lys Thr Arg           
                85                  90                  95                

ttc atc atc cat ggc ttc ata gac aaa gga gat gag agc tgg gtg aca        336
Phe Ile Ile His Gly Phe Ile Asp Lys Gly Asp Glu Ser Trp Val Thr           
            100                 105                 110                   

gac atg tgc aag aaa ctg ttc gag gtg gag gag gtg aac tgc atc tgc        384
Asp Met Cys Lys Lys Leu Phe Glu Val Glu Glu Val Asn Cys Ile Cys           
        115                 120                 125                       

gtg gac tgg aag aag ggc tcc caa gcc acc tac aca cag gct gcc aac        432
Val Asp Trp Lys Lys Gly Ser Gln Ala Thr Tyr Thr Gln Ala Ala Asn           
    130                 135                 140                           

aac gtg cga gtg gtg ggc gcc cag gtg gcc cag atg ctc gac atc ctc        480
Asn Val Arg Val Val Gly Ala Gln Val Ala Gln Met Leu Asp Ile Leu           
145                 150                 155                 160           

ttg aca gag tat agc tac ccc cct tcc aaa gtt cac ctc att ggc cac        528
Leu Thr Glu Tyr Ser Tyr Pro Pro Ser Lys Val His Leu Ile Gly His           
                165                 170                 175               

agc ctg gga gcc cac gtg gct gga gag gca gga agc aag act cca ggc        576
Ser Leu Gly Ala His Val Ala Gly Glu Ala Gly Ser Lys Thr Pro Gly           
            180                 185                 190                   

ctg agc agg att aca ggg ttg gat cct gta gaa gca agt ttc gag agt        624
Leu Ser Arg Ile Thr Gly Leu Asp Pro Val Glu Ala Ser Phe Glu Ser           
        195                 200                 205                       

act cct gaa gag gtg cga ctt gat ccc tct gat gct gac ttt gtt gat        672
Thr Pro Glu Glu Val Arg Leu Asp Pro Ser Asp Ala Asp Phe Val Asp           
    210                 215                 220                           

gtg att cac acg gat gca gct ccc ctg atc cca ttc ttg ggt ttt gga        720
Val Ile His Thr Asp Ala Ala Pro Leu Ile Pro Phe Leu Gly Phe Gly           
225                 230                 235                 240           

acg aac caa cag atg ggt cat ctt gac ttc ttc ccc aat gga gga gag        768
Thr Asn Gln Gln Met Gly His Leu Asp Phe Phe Pro Asn Gly Gly Glu           
                245                 250                 255               

agc atg ccg gga tgc aag aag aat gcc ctg tct cag atc gtg gat cta        816
Ser Met Pro Gly Cys Lys Lys Asn Ala Leu Ser Gln Ile Val Asp Leu           
            260                 265                 270                   

gat ggc atc tgg gcg gga acc cgg gac ttt gtg gct tgc aat cac cta        864
Asp Gly Ile Trp Ala Gly Thr Arg Asp Phe Val Ala Cys Asn His Leu           
        275                 280                 285                       

aga agc tac aag tat tac ttg gaa agc atc ctc aat ccc gat ggg ttt        912
Arg Ser Tyr Lys Tyr Tyr Leu Glu Ser Ile Leu Asn Pro Asp Gly Phe           
    290                 295                 300                           

gct gca tat ccc tgc act tcc tac aag tcc ttt gag tct gac aag tgc        960
Ala Ala Tyr Pro Cys Thr Ser Tyr Lys Ser Phe Glu Ser Asp Lys Cys           
305                 310                 315                 320           

ttc ccg tgt cca gat caa gga tgc cca cag atg ggt cac tat gct gat       1008
Phe Pro Cys Pro Asp Gln Gly Cys Pro Gln Met Gly His Tyr Ala Asp           
                325                 330                 335               

aaa ttt gct ggc agg aca agt gaa gag cag cag aaa ttc ttc ttg aac       1056
Lys Phe Ala Gly Arg Thr Ser Glu Glu Gln Gln Lys Phe Phe Leu Asn           
            340                 345                 350                   

aca gga gag gct agc aat ttc gct cgc tgg aga tat ggg gtt tcc atc       1104
Thr Gly Glu Ala Ser Asn Phe Ala Arg Trp Arg Tyr Gly Val Ser Ile           
        355                 360                 365                       

aca ctg tct gga aga aca gcc act ggt cag atc aaa gtt gct ttg ttt       1152
Thr Leu Ser Gly Arg Thr Ala Thr Gly Gln Ile Lys Val Ala Leu Phe           
    370                 375                 380                           

gga aat aag gga aac act cac cag tac agc atc ttc agg ggg att ctc       1200
Gly Asn Lys Gly Asn Thr His Gln Tyr Ser Ile Phe Arg Gly Ile Leu           
385                 390                 395                 400           

aaa cca ggc tca acc cat tcc tat gag ttt gat gca aag ctg gat gtt       1248
Lys Pro Gly Ser Thr His Ser Tyr Glu Phe Asp Ala Lys Leu Asp Val           
                405                 410                 415               

gga aca att gag aaa gtc aag ttt ctt tgg aat aac aat gtg ata aat       1296
Gly Thr Ile Glu Lys Val Lys Phe Leu Trp Asn Asn Asn Val Ile Asn           
            420                 425                 430                   

cca acc ctc ccc aaa gtg ggt gcc acc aag atc act gtg caa aag gga       1344
Pro Thr Leu Pro Lys Val Gly Ala Thr Lys Ile Thr Val Gln Lys Gly           
        435                 440                 445                       

gaa gag aag aca gtg tac aac ttc tgt agc gaa gac aca gtg cgg gaa       1392
Glu Glu Lys Thr Val Tyr Asn Phe Cys Ser Glu Asp Thr Val Arg Glu           
    450                 455                 460                           

gac acg ctg ctc accctcacgc cctgctaagc tcccggggcg acgaggctgc           1444
Asp Thr Leu Leu                                                           
465                                                                       

tgcgttcaca ctaataaaat ccactggtgc atctgt                               1480


<210>  442
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  442

Ser Gly Thr Leu Asp Arg Met Leu Ile Phe Trp Thr Ile Thr Leu Phe 
1               5                   10                  15      


Leu Leu Gly Ala Ala Lys Gly Lys Glu Val Cys Tyr Glu Asp Leu Gly 
            20                  25                  30          


Cys Phe Ser Asp Thr Glu Pro Trp Gly Gly Thr Ala Ile Arg Pro Leu 
        35                  40                  45              


Lys Ile Leu Pro Trp Ser Pro Glu Lys Ile Gly Thr Arg Phe Leu Leu 
    50                  55                  60                  


Tyr Thr Asn Glu Asn Pro Asn Asn Phe Gln Ile Leu Leu Leu Ser Asp 
65                  70                  75                  80  


Pro Ser Thr Ile Glu Ala Ser Asn Phe Gln Met Asp Arg Lys Thr Arg 
                85                  90                  95      


Phe Ile Ile His Gly Phe Ile Asp Lys Gly Asp Glu Ser Trp Val Thr 
            100                 105                 110         


Asp Met Cys Lys Lys Leu Phe Glu Val Glu Glu Val Asn Cys Ile Cys 
        115                 120                 125             


Val Asp Trp Lys Lys Gly Ser Gln Ala Thr Tyr Thr Gln Ala Ala Asn 
    130                 135                 140                 


Asn Val Arg Val Val Gly Ala Gln Val Ala Gln Met Leu Asp Ile Leu 
145                 150                 155                 160 


Leu Thr Glu Tyr Ser Tyr Pro Pro Ser Lys Val His Leu Ile Gly His 
                165                 170                 175     


Ser Leu Gly Ala His Val Ala Gly Glu Ala Gly Ser Lys Thr Pro Gly 
            180                 185                 190         


Leu Ser Arg Ile Thr Gly Leu Asp Pro Val Glu Ala Ser Phe Glu Ser 
        195                 200                 205             


Thr Pro Glu Glu Val Arg Leu Asp Pro Ser Asp Ala Asp Phe Val Asp 
    210                 215                 220                 


Val Ile His Thr Asp Ala Ala Pro Leu Ile Pro Phe Leu Gly Phe Gly 
225                 230                 235                 240 


Thr Asn Gln Gln Met Gly His Leu Asp Phe Phe Pro Asn Gly Gly Glu 
                245                 250                 255     


Ser Met Pro Gly Cys Lys Lys Asn Ala Leu Ser Gln Ile Val Asp Leu 
            260                 265                 270         


Asp Gly Ile Trp Ala Gly Thr Arg Asp Phe Val Ala Cys Asn His Leu 
        275                 280                 285             


Arg Ser Tyr Lys Tyr Tyr Leu Glu Ser Ile Leu Asn Pro Asp Gly Phe 
    290                 295                 300                 


Ala Ala Tyr Pro Cys Thr Ser Tyr Lys Ser Phe Glu Ser Asp Lys Cys 
305                 310                 315                 320 


Phe Pro Cys Pro Asp Gln Gly Cys Pro Gln Met Gly His Tyr Ala Asp 
                325                 330                 335     


Lys Phe Ala Gly Arg Thr Ser Glu Glu Gln Gln Lys Phe Phe Leu Asn 
            340                 345                 350         


Thr Gly Glu Ala Ser Asn Phe Ala Arg Trp Arg Tyr Gly Val Ser Ile 
        355                 360                 365             


Thr Leu Ser Gly Arg Thr Ala Thr Gly Gln Ile Lys Val Ala Leu Phe 
    370                 375                 380                 


Gly Asn Lys Gly Asn Thr His Gln Tyr Ser Ile Phe Arg Gly Ile Leu 
385                 390                 395                 400 


Lys Pro Gly Ser Thr His Ser Tyr Glu Phe Asp Ala Lys Leu Asp Val 
                405                 410                 415     


Gly Thr Ile Glu Lys Val Lys Phe Leu Trp Asn Asn Asn Val Ile Asn 
            420                 425                 430         


Pro Thr Leu Pro Lys Val Gly Ala Thr Lys Ile Thr Val Gln Lys Gly 
        435                 440                 445             


Glu Glu Lys Thr Val Tyr Asn Phe Cys Ser Glu Asp Thr Val Arg Glu 
    450                 455                 460                 


Asp Thr Leu Leu 
465             


<210>  443
<211>  1599
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (107)..(985)

<400>  443
agtggggcgg ggctcccggt tccaggcgag ttcgcagctg cgcgccgggt cctggaggcc       60

gaggccgctc ccgcccgttg tccccgcagt ccccgacggg agcgcc atg gcc cag         115
                                                   Met Ala Gln            
                                                   1                      

ccg ccg ccc gac gtg gag ggg gac gac tgt ctc ccc gcg tac cgc cac        163
Pro Pro Pro Asp Val Glu Gly Asp Asp Cys Leu Pro Ala Tyr Arg His           
    5                   10                  15                            

ctc ttc tgc ccg gac ctg ctg cgg gac aaa gtg gcc ttc atc aca gga        211
Leu Phe Cys Pro Asp Leu Leu Arg Asp Lys Val Ala Phe Ile Thr Gly           
20                  25                  30                  35            

ggc ggc tct ggg att ggg ttc cgg att gct gag att ttc atg cgg cac        259
Gly Gly Ser Gly Ile Gly Phe Arg Ile Ala Glu Ile Phe Met Arg His           
                40                  45                  50                

ggc tgc cat acg gtg att gcc agt agg agc ctg ccg cga gtg ctg acg        307
Gly Cys His Thr Val Ile Ala Ser Arg Ser Leu Pro Arg Val Leu Thr           
            55                  60                  65                    

gcc gcc agg aag ctg gct ggg gcc acc ggc cgg cgc tgc ctc cct ctc        355
Ala Ala Arg Lys Leu Ala Gly Ala Thr Gly Arg Arg Cys Leu Pro Leu           
        70                  75                  80                        

tct atg gac gtc cga gcg ccc cca gct gtc atg gcc gcc gtg gac cag        403
Ser Met Asp Val Arg Ala Pro Pro Ala Val Met Ala Ala Val Asp Gln           
    85                  90                  95                            

gct ctg aag gag ttt ggc aga atc gac att ctc att aac tgt gcg gcc        451
Ala Leu Lys Glu Phe Gly Arg Ile Asp Ile Leu Ile Asn Cys Ala Ala           
100                 105                 110                 115           

ggg aac ttc ctg tgc ccc gct ggc gcc ttg tcc ttc aac gcc ttc aag        499
Gly Asn Phe Leu Cys Pro Ala Gly Ala Leu Ser Phe Asn Ala Phe Lys           
                120                 125                 130               

acc gtg atg gac atc gat acc agc ggc acc ttc aat gtg tct cgt gtg        547
Thr Val Met Asp Ile Asp Thr Ser Gly Thr Phe Asn Val Ser Arg Val           
            135                 140                 145                   

ctc tat gag aag ttc ttc cgg gac cac gga ggg gtg atc gtg aac atc        595
Leu Tyr Glu Lys Phe Phe Arg Asp His Gly Gly Val Ile Val Asn Ile           
        150                 155                 160                       

act gcc acc ctg ggg aac cgg ggg cag gcg ctc cag gtg cat gca ggc        643
Thr Ala Thr Leu Gly Asn Arg Gly Gln Ala Leu Gln Val His Ala Gly           
    165                 170                 175                           

tcc gcc aag gcc gct gtg gac gcg atg acg cgg cac ttg gct gtg gag        691
Ser Ala Lys Ala Ala Val Asp Ala Met Thr Arg His Leu Ala Val Glu           
180                 185                 190                 195           

tgg ggt ccc caa aac atc cgc gtc aac agc ctc gcc cct ggc ccc atc        739
Trp Gly Pro Gln Asn Ile Arg Val Asn Ser Leu Ala Pro Gly Pro Ile           
                200                 205                 210               

agt ggc aca gag ggg ctc cgg cga ctg ggt ggc cct cag gcc agc ctg        787
Ser Gly Thr Glu Gly Leu Arg Arg Leu Gly Gly Pro Gln Ala Ser Leu           
            215                 220                 225                   

agc acc aag gtc act gcc agc ccg ctg cag agg ctg ggg aac aag acc        835
Ser Thr Lys Val Thr Ala Ser Pro Leu Gln Arg Leu Gly Asn Lys Thr           
        230                 235                 240                       

gag atc gcc cac agc gtg ctc tac ctg gcc agc cct ctg gct tcc tac        883
Glu Ile Ala His Ser Val Leu Tyr Leu Ala Ser Pro Leu Ala Ser Tyr           
    245                 250                 255                           

gtg acg ggg gcc gtg ctg gtg gcc gat ggc ggg gca tgg ttg acg ttc        931
Val Thr Gly Ala Val Leu Val Ala Asp Gly Gly Ala Trp Leu Thr Phe           
260                 265                 270                 275           

cca aac ggt gtc aaa ggg ctg ccg gat ttc gca tcc ttc tct gct aag        979
Pro Asn Gly Val Lys Gly Leu Pro Asp Phe Ala Ser Phe Ser Ala Lys           
                280                 285                 290               

ctc tag gaatcttccg gccgctgctt cctgccgcct cactcagcca ggtggagagc        1035
Leu                                                                       
                                                                          

accaatctga accagcaatg cctgcagccc agcccctcct ctgaacactc agctattact     1095

gcgctttccc tccccacggc cccaactcca gggcaggagc aactggacag tgggcctggc     1155

ccgtggagct gccacgcagg tgcctgaggg ccaggtgcca cgcaggtgtc tgaggaccag     1215

gtgccacgca ggtggtgggg gtacagacaa gatgctggga tgtcccctgc cccatggtca     1275

agggtgtcct gcctgcctgg gtccagggcc tgagggagcc acatggatcc cgagacttgt     1335

gttctcttgg ctgaaaacac tgaggtgctc ccatctgtgc gtggcccatg agctgggatg     1395

gtcctccagc tgcccacaag gtccgcccct ctgtctctgc accacctgtt tgcataaaca     1455

cactttgcta caatcttgct agtgcgtttt cttaaaagat aatctattta ctgtaaaaat     1515

aaattggact ttgcaaaagc ttttagaagg aaaagaaaga ggattaaaga gaattgctgg     1575

tgatcctaaa aaaaaaaaaa aaaa                                            1599


<210>  444
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  444

Met Ala Gln Pro Pro Pro Asp Val Glu Gly Asp Asp Cys Leu Pro Ala 
1               5                   10                  15      


Tyr Arg His Leu Phe Cys Pro Asp Leu Leu Arg Asp Lys Val Ala Phe 
            20                  25                  30          


Ile Thr Gly Gly Gly Ser Gly Ile Gly Phe Arg Ile Ala Glu Ile Phe 
        35                  40                  45              


Met Arg His Gly Cys His Thr Val Ile Ala Ser Arg Ser Leu Pro Arg 
    50                  55                  60                  


Val Leu Thr Ala Ala Arg Lys Leu Ala Gly Ala Thr Gly Arg Arg Cys 
65                  70                  75                  80  


Leu Pro Leu Ser Met Asp Val Arg Ala Pro Pro Ala Val Met Ala Ala 
                85                  90                  95      


Val Asp Gln Ala Leu Lys Glu Phe Gly Arg Ile Asp Ile Leu Ile Asn 
            100                 105                 110         


Cys Ala Ala Gly Asn Phe Leu Cys Pro Ala Gly Ala Leu Ser Phe Asn 
        115                 120                 125             


Ala Phe Lys Thr Val Met Asp Ile Asp Thr Ser Gly Thr Phe Asn Val 
    130                 135                 140                 


Ser Arg Val Leu Tyr Glu Lys Phe Phe Arg Asp His Gly Gly Val Ile 
145                 150                 155                 160 


Val Asn Ile Thr Ala Thr Leu Gly Asn Arg Gly Gln Ala Leu Gln Val 
                165                 170                 175     


His Ala Gly Ser Ala Lys Ala Ala Val Asp Ala Met Thr Arg His Leu 
            180                 185                 190         


Ala Val Glu Trp Gly Pro Gln Asn Ile Arg Val Asn Ser Leu Ala Pro 
        195                 200                 205             


Gly Pro Ile Ser Gly Thr Glu Gly Leu Arg Arg Leu Gly Gly Pro Gln 
    210                 215                 220                 


Ala Ser Leu Ser Thr Lys Val Thr Ala Ser Pro Leu Gln Arg Leu Gly 
225                 230                 235                 240 


Asn Lys Thr Glu Ile Ala His Ser Val Leu Tyr Leu Ala Ser Pro Leu 
                245                 250                 255     


Ala Ser Tyr Val Thr Gly Ala Val Leu Val Ala Asp Gly Gly Ala Trp 
            260                 265                 270         


Leu Thr Phe Pro Asn Gly Val Lys Gly Leu Pro Asp Phe Ala Ser Phe 
        275                 280                 285             


Ser Ala Lys Leu 
    290         


<210>  445
<211>  2292
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (294)..(2036)

<400>  445
gctcgccaac ggccgacgct ccaggccgtc ccgcccagcg cagctgcacc caatcacaat       60

gctcagatcg ggaggtggag ccaatcaggt ccaaccaaga ggaggggaca ccggcactcc      120

actagcagga aaacgggccg agggaccgca agcagggggt gcctagtcct cgtcccccaa      180

agaccaatcg taagccagat acaggcgagt gactgtcaag aaggccaatt agagcctccg      240

aagggaatct ggacctgcct cttctctgag ggacggctct acctaccaat agc atg         296
                                                           Met            
                                                           1              

ggc gag aag gcg gtc cct ttg cta agg agg agg cgg gtg aag aga agc        344
Gly Glu Lys Ala Val Pro Leu Leu Arg Arg Arg Arg Val Lys Arg Ser           
            5                   10                  15                    

tgc cct tct tgt ggc tcg gag ctt ggg gtt gaa gag aag agg ggg aaa        392
Cys Pro Ser Cys Gly Ser Glu Leu Gly Val Glu Glu Lys Arg Gly Lys           
        20                  25                  30                        

gga aat ccg att tcc atc cag ttg ttc ccc cca gag ctg gtg gag cat        440
Gly Asn Pro Ile Ser Ile Gln Leu Phe Pro Pro Glu Leu Val Glu His           
    35                  40                  45                            

atc atc tca ttc ctc cca gtc aga gac ctt gtt gcc ctc ggc cag acc        488
Ile Ile Ser Phe Leu Pro Val Arg Asp Leu Val Ala Leu Gly Gln Thr           
50                  55                  60                  65            

tgc cgc tac ttc cac gaa gtg tgc gat ggg gaa ggc gtg tgg aga cgc        536
Cys Arg Tyr Phe His Glu Val Cys Asp Gly Glu Gly Val Trp Arg Arg           
                70                  75                  80                

atc tgt cgc aga ctc agt ccg cgc ctc caa gat cag ggt tct gga gtc        584
Ile Cys Arg Arg Leu Ser Pro Arg Leu Gln Asp Gln Gly Ser Gly Val           
            85                  90                  95                    

cgg ccc tgg aag aga gct gcc att ctg aac tac acg aag ggc ctg tat        632
Arg Pro Trp Lys Arg Ala Ala Ile Leu Asn Tyr Thr Lys Gly Leu Tyr           
        100                 105                 110                       

ttc cag gca ttt gga ggc cgc cgc cga tgt ctc agc aag agc gtg gcc        680
Phe Gln Ala Phe Gly Gly Arg Arg Arg Cys Leu Ser Lys Ser Val Ala           
    115                 120                 125                           

ccc ttg cta gcc cac ggc tac cgc cgc ttc ttg ccc acc aag gat cac        728
Pro Leu Leu Ala His Gly Tyr Arg Arg Phe Leu Pro Thr Lys Asp His           
130                 135                 140                 145           

gtc ttc att ctt gac tac gtg ggg acc ctc ttc ttc ctc aaa aat gcc        776
Val Phe Ile Leu Asp Tyr Val Gly Thr Leu Phe Phe Leu Lys Asn Ala           
                150                 155                 160               

ctg gtc tcc acc ctc ggc cag atg cag tgg aag cgg gcc tgt cgc tat        824
Leu Val Ser Thr Leu Gly Gln Met Gln Trp Lys Arg Ala Cys Arg Tyr           
            165                 170                 175                   

gtt gtg ttg tgt cgt gga gcc aag gat ttt gcc tcg gac cca agg tgt        872
Val Val Leu Cys Arg Gly Ala Lys Asp Phe Ala Ser Asp Pro Arg Cys           
        180                 185                 190                       

gac aca gtt tac cgt aaa tac ctc tac gtc ttg gcc act cgg gag ccg        920
Asp Thr Val Tyr Arg Lys Tyr Leu Tyr Val Leu Ala Thr Arg Glu Pro           
    195                 200                 205                           

cag gaa gtg gtg ggt acc acc agc agc cgg gcc tgt gac tgt gtt gag        968
Gln Glu Val Val Gly Thr Thr Ser Ser Arg Ala Cys Asp Cys Val Glu           
210                 215                 220                 225           

gtc tat ctg cag tct agt ggg cag cgg gtc ttc aag atg aca ttc cac       1016
Val Tyr Leu Gln Ser Ser Gly Gln Arg Val Phe Lys Met Thr Phe His           
                230                 235                 240               

cac tca atg acc ttc aag cag atc gtg ctg gtt ggt cag gag acc cag       1064
His Ser Met Thr Phe Lys Gln Ile Val Leu Val Gly Gln Glu Thr Gln           
            245                 250                 255                   

cgg gct cta ctg ctc ctc aca gag gaa gga aag atc tac tct ttg gta       1112
Arg Ala Leu Leu Leu Leu Thr Glu Glu Gly Lys Ile Tyr Ser Leu Val           
        260                 265                 270                       

gtg aat gag acc cag ctt gac cag cca cgc tcc tac acg gtt cag ctg       1160
Val Asn Glu Thr Gln Leu Asp Gln Pro Arg Ser Tyr Thr Val Gln Leu           
    275                 280                 285                           

gcc ctg agg aag gtg tcc cac tac ctg cct cac ctg cgc gtg gcc tgc       1208
Ala Leu Arg Lys Val Ser His Tyr Leu Pro His Leu Arg Val Ala Cys           
290                 295                 300                 305           

atg act tcc aac cag agc agc acc ctc tac gtc aca gac cag ggg gga       1256
Met Thr Ser Asn Gln Ser Ser Thr Leu Tyr Val Thr Asp Gln Gly Gly           
                310                 315                 320               

gtg tat ttt gag gtg cat acc cca ggg gtg tat cgc gat ctc ttt ggg       1304
Val Tyr Phe Glu Val His Thr Pro Gly Val Tyr Arg Asp Leu Phe Gly           
            325                 330                 335                   

acc ctt caa gcc ttt gac ccc ctg gac cag cag atg ccg ctt gct ctc       1352
Thr Leu Gln Ala Phe Asp Pro Leu Asp Gln Gln Met Pro Leu Ala Leu           
        340                 345                 350                       

tca ctg cct gcc aag atc cta ttc tgt gct ctt ggc tac aac cac ctt       1400
Ser Leu Pro Ala Lys Ile Leu Phe Cys Ala Leu Gly Tyr Asn His Leu           
    355                 360                 365                           

ggc ctg gtg gat gaa ttt ggc cga atc ttc atg caa gga aat aac aga       1448
Gly Leu Val Asp Glu Phe Gly Arg Ile Phe Met Gln Gly Asn Asn Arg           
370                 375                 380                 385           

tac ggg cag cta gga aca ggg gac aaa atg gac cga ggg gaa ccc aca       1496
Tyr Gly Gln Leu Gly Thr Gly Asp Lys Met Asp Arg Gly Glu Pro Thr           
                390                 395                 400               

cag gtt tgt tac ctg cag cgg ccc atc acc ctg tgg tgc ggc ctc aac       1544
Gln Val Cys Tyr Leu Gln Arg Pro Ile Thr Leu Trp Cys Gly Leu Asn           
            405                 410                 415                   

cac tcc ctg gtg ctg agc cag agc tca gag ttc agc aag gag ctg ctg       1592
His Ser Leu Val Leu Ser Gln Ser Ser Glu Phe Ser Lys Glu Leu Leu           
        420                 425                 430                       

ggc tgc ggc tgt ggg gct ggg ggc cgc ctc cca ggc tgg ccc aag ggg       1640
Gly Cys Gly Cys Gly Ala Gly Gly Arg Leu Pro Gly Trp Pro Lys Gly           
    435                 440                 445                           

agt gcc tcc ttc gtc aag ctc caa gtc aag gtc cct ctg tgt gcc tgt       1688
Ser Ala Ser Phe Val Lys Leu Gln Val Lys Val Pro Leu Cys Ala Cys           
450                 455                 460                 465           

gcc ctc tgt gcc acc agg gag tgc cta tac atc ctg tcc agc cac gac       1736
Ala Leu Cys Ala Thr Arg Glu Cys Leu Tyr Ile Leu Ser Ser His Asp           
                470                 475                 480               

att gag cag cac gcc ccc tat cgc cac ctg cca gcc agc agg gtg gtg       1784
Ile Glu Gln His Ala Pro Tyr Arg His Leu Pro Ala Ser Arg Val Val           
            485                 490                 495                   

ggg act cct gag ccc agc ctg ggg gcc aga gca ccc cag gac ccc ggg       1832
Gly Thr Pro Glu Pro Ser Leu Gly Ala Arg Ala Pro Gln Asp Pro Gly           
        500                 505                 510                       

ggg atg gcc cag gcc tgc gag gag tac ctc agc cag atc cac agt tgc       1880
Gly Met Ala Gln Ala Cys Glu Glu Tyr Leu Ser Gln Ile His Ser Cys           
    515                 520                 525                           

caa acg ttg cag gac cgc acg gag aag atg aag gag atc gta ggg tgg       1928
Gln Thr Leu Gln Asp Arg Thr Glu Lys Met Lys Glu Ile Val Gly Trp           
530                 535                 540                 545           

atg ccc ctg atg gcc gca cag aag gac ttc ttc tgg gag gcc ctg gac       1976
Met Pro Leu Met Ala Ala Gln Lys Asp Phe Phe Trp Glu Ala Leu Asp           
                550                 555                 560               

atg ctg cag agg gct gaa gga ggc ggg ggt ggt gta ggg ccc cca gcc       2024
Met Leu Gln Arg Ala Glu Gly Gly Gly Gly Gly Val Gly Pro Pro Ala           
            565                 570                 575                   

cct gag acc taa tccccctcat gctagcctag tccctggagg agggagtccg           2076
Pro Glu Thr                                                               
        580                                                               

gccccaggcc agggactaag gagcaatgac cattgtgcac atgcgtgtgg gaaggggttg     2136

ctagggggtg gggacggcta accagggtaa gaatgttcag ggggctgccc aggaggggcc     2196

cccaacctga ctatcatgga caagagattt gatggataga ataaaaggct gcagcgagaa     2256

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                               2292


<210>  446
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  446

Met Gly Glu Lys Ala Val Pro Leu Leu Arg Arg Arg Arg Val Lys Arg 
1               5                   10                  15      


Ser Cys Pro Ser Cys Gly Ser Glu Leu Gly Val Glu Glu Lys Arg Gly 
            20                  25                  30          


Lys Gly Asn Pro Ile Ser Ile Gln Leu Phe Pro Pro Glu Leu Val Glu 
        35                  40                  45              


His Ile Ile Ser Phe Leu Pro Val Arg Asp Leu Val Ala Leu Gly Gln 
    50                  55                  60                  


Thr Cys Arg Tyr Phe His Glu Val Cys Asp Gly Glu Gly Val Trp Arg 
65                  70                  75                  80  


Arg Ile Cys Arg Arg Leu Ser Pro Arg Leu Gln Asp Gln Gly Ser Gly 
                85                  90                  95      


Val Arg Pro Trp Lys Arg Ala Ala Ile Leu Asn Tyr Thr Lys Gly Leu 
            100                 105                 110         


Tyr Phe Gln Ala Phe Gly Gly Arg Arg Arg Cys Leu Ser Lys Ser Val 
        115                 120                 125             


Ala Pro Leu Leu Ala His Gly Tyr Arg Arg Phe Leu Pro Thr Lys Asp 
    130                 135                 140                 


His Val Phe Ile Leu Asp Tyr Val Gly Thr Leu Phe Phe Leu Lys Asn 
145                 150                 155                 160 


Ala Leu Val Ser Thr Leu Gly Gln Met Gln Trp Lys Arg Ala Cys Arg 
                165                 170                 175     


Tyr Val Val Leu Cys Arg Gly Ala Lys Asp Phe Ala Ser Asp Pro Arg 
            180                 185                 190         


Cys Asp Thr Val Tyr Arg Lys Tyr Leu Tyr Val Leu Ala Thr Arg Glu 
        195                 200                 205             


Pro Gln Glu Val Val Gly Thr Thr Ser Ser Arg Ala Cys Asp Cys Val 
    210                 215                 220                 


Glu Val Tyr Leu Gln Ser Ser Gly Gln Arg Val Phe Lys Met Thr Phe 
225                 230                 235                 240 


His His Ser Met Thr Phe Lys Gln Ile Val Leu Val Gly Gln Glu Thr 
                245                 250                 255     


Gln Arg Ala Leu Leu Leu Leu Thr Glu Glu Gly Lys Ile Tyr Ser Leu 
            260                 265                 270         


Val Val Asn Glu Thr Gln Leu Asp Gln Pro Arg Ser Tyr Thr Val Gln 
        275                 280                 285             


Leu Ala Leu Arg Lys Val Ser His Tyr Leu Pro His Leu Arg Val Ala 
    290                 295                 300                 


Cys Met Thr Ser Asn Gln Ser Ser Thr Leu Tyr Val Thr Asp Gln Gly 
305                 310                 315                 320 


Gly Val Tyr Phe Glu Val His Thr Pro Gly Val Tyr Arg Asp Leu Phe 
                325                 330                 335     


Gly Thr Leu Gln Ala Phe Asp Pro Leu Asp Gln Gln Met Pro Leu Ala 
            340                 345                 350         


Leu Ser Leu Pro Ala Lys Ile Leu Phe Cys Ala Leu Gly Tyr Asn His 
        355                 360                 365             


Leu Gly Leu Val Asp Glu Phe Gly Arg Ile Phe Met Gln Gly Asn Asn 
    370                 375                 380                 


Arg Tyr Gly Gln Leu Gly Thr Gly Asp Lys Met Asp Arg Gly Glu Pro 
385                 390                 395                 400 


Thr Gln Val Cys Tyr Leu Gln Arg Pro Ile Thr Leu Trp Cys Gly Leu 
                405                 410                 415     


Asn His Ser Leu Val Leu Ser Gln Ser Ser Glu Phe Ser Lys Glu Leu 
            420                 425                 430         


Leu Gly Cys Gly Cys Gly Ala Gly Gly Arg Leu Pro Gly Trp Pro Lys 
        435                 440                 445             


Gly Ser Ala Ser Phe Val Lys Leu Gln Val Lys Val Pro Leu Cys Ala 
    450                 455                 460                 


Cys Ala Leu Cys Ala Thr Arg Glu Cys Leu Tyr Ile Leu Ser Ser His 
465                 470                 475                 480 


Asp Ile Glu Gln His Ala Pro Tyr Arg His Leu Pro Ala Ser Arg Val 
                485                 490                 495     


Val Gly Thr Pro Glu Pro Ser Leu Gly Ala Arg Ala Pro Gln Asp Pro 
            500                 505                 510         


Gly Gly Met Ala Gln Ala Cys Glu Glu Tyr Leu Ser Gln Ile His Ser 
        515                 520                 525             


Cys Gln Thr Leu Gln Asp Arg Thr Glu Lys Met Lys Glu Ile Val Gly 
    530                 535                 540                 


Trp Met Pro Leu Met Ala Ala Gln Lys Asp Phe Phe Trp Glu Ala Leu 
545                 550                 555                 560 


Asp Met Leu Gln Arg Ala Glu Gly Gly Gly Gly Gly Val Gly Pro Pro 
                565                 570                 575     


Ala Pro Glu Thr 
            580 


<210>  447
<211>  3460
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (88)..(1791)

<400>  447
cgagcccaca tccgggagag gagagcggaa gtggcgttgg tctggccgga gcccttgggt       60

gaaattgtta ggcgtggaga gggagtg atg tct tcc aga ctc ggt gct gta ccc      114
                              Met Ser Ser Arg Leu Gly Ala Val Pro         
                              1               5                           

gcc act tcg gga ccc aca acc ttt aag cag cag agg agc acg agg atc        162
Ala Thr Ser Gly Pro Thr Thr Phe Lys Gln Gln Arg Ser Thr Arg Ile           
10                  15                  20                  25            

gtg gga gct aag aat agc agg acc cag tgc tcc ata aag gat aat agt        210
Val Gly Ala Lys Asn Ser Arg Thr Gln Cys Ser Ile Lys Asp Asn Ser           
                30                  35                  40                

ttc cag tac act atc cct cat gat gac tcc tta agt ggt tca tcg tct        258
Phe Gln Tyr Thr Ile Pro His Asp Asp Ser Leu Ser Gly Ser Ser Ser           
            45                  50                  55                    

gca tct tcg tgt gaa cca gtg agt gat ttt cca gca tct ttc cga aaa        306
Ala Ser Ser Cys Glu Pro Val Ser Asp Phe Pro Ala Ser Phe Arg Lys           
        60                  65                  70                        

tct acc tac tgg atg aag atg aga aga atc aag cca gct gct act tct        354
Ser Thr Tyr Trp Met Lys Met Arg Arg Ile Lys Pro Ala Ala Thr Ser           
    75                  80                  85                            

cat gtc gaa ggg tca ggt gga gta tca gcc aag ggg aaa agg aaa ccc        402
His Val Glu Gly Ser Gly Gly Val Ser Ala Lys Gly Lys Arg Lys Pro           
90                  95                  100                 105           

agg cag gaa gaa gat gaa gac tat cga gaa ttt cct cag aag aag cat        450
Arg Gln Glu Glu Asp Glu Asp Tyr Arg Glu Phe Pro Gln Lys Lys His           
                110                 115                 120               

aag ctt tat ggg agg aag caa cgg cct aaa act cag ccc aat ccc aaa        498
Lys Leu Tyr Gly Arg Lys Gln Arg Pro Lys Thr Gln Pro Asn Pro Lys           
            125                 130                 135                   

tcc cag gcc cgt cgt att cgg aag gaa cca cca gtt tat gca gca ggc        546
Ser Gln Ala Arg Arg Ile Arg Lys Glu Pro Pro Val Tyr Ala Ala Gly           
        140                 145                 150                       

agt ttg gag gag caa tgg tac tta gaa atc gtt gat aaa ggc agt gtc        594
Ser Leu Glu Glu Gln Trp Tyr Leu Glu Ile Val Asp Lys Gly Ser Val           
    155                 160                 165                           

tcc tgc cct acc tgc cag gca gtg ggg agg aag acc ata gag ggt tta        642
Ser Cys Pro Thr Cys Gln Ala Val Gly Arg Lys Thr Ile Glu Gly Leu           
170                 175                 180                 185           

aag aaa cac atg gaa aac tgc aag cag gaa atg ttt act tgt cat cat        690
Lys Lys His Met Glu Asn Cys Lys Gln Glu Met Phe Thr Cys His His           
                190                 195                 200               

tgt ggg aaa caa ctt cgt tca ctg gca ggg atg aag tat cat gtc atg        738
Cys Gly Lys Gln Leu Arg Ser Leu Ala Gly Met Lys Tyr His Val Met           
            205                 210                 215                   

gca aat cat aat agt ttg ccc att ttg aaa gcc gga gat gaa ata gat        786
Ala Asn His Asn Ser Leu Pro Ile Leu Lys Ala Gly Asp Glu Ile Asp           
        220                 225                 230                       

gag cca agt gag agg gaa agg ctc cga aca gtt cta aag aga ctg gga        834
Glu Pro Ser Glu Arg Glu Arg Leu Arg Thr Val Leu Lys Arg Leu Gly           
    235                 240                 245                           

aag ctc agg tgc atg cgt gag agt tgc tcc agt agc ttc acc agc atc        882
Lys Leu Arg Cys Met Arg Glu Ser Cys Ser Ser Ser Phe Thr Ser Ile           
250                 255                 260                 265           

atg gga tat ctc tac cat gtc aga aaa tgt ggc aaa ggg gct gca gag        930
Met Gly Tyr Leu Tyr His Val Arg Lys Cys Gly Lys Gly Ala Ala Glu           
                270                 275                 280               

ctg gaa aag atg acc ctg aaa tgt cac cac tgt gga aaa cca tat agg        978
Leu Glu Lys Met Thr Leu Lys Cys His His Cys Gly Lys Pro Tyr Arg           
            285                 290                 295                   

tcg aag gct gga ctt gca tat cac ctg agg tca gag cat ggg cct ata       1026
Ser Lys Ala Gly Leu Ala Tyr His Leu Arg Ser Glu His Gly Pro Ile           
        300                 305                 310                       

tcc ttc ttt cca gag tca gga cag cca gag tgc tta aag gag atg aac       1074
Ser Phe Phe Pro Glu Ser Gly Gln Pro Glu Cys Leu Lys Glu Met Asn           
    315                 320                 325                           

cta gag tca aag agt ggg ggc cga gtt cag aga cgt tct gcc aag ata       1122
Leu Glu Ser Lys Ser Gly Gly Arg Val Gln Arg Arg Ser Ala Lys Ile           
330                 335                 340                 345           

gct gta tac cac cta cag gag ctg gcc tct gct gaa ctg gcc aag gaa       1170
Ala Val Tyr His Leu Gln Glu Leu Ala Ser Ala Glu Leu Ala Lys Glu           
                350                 355                 360               

tgg ccc aag agg aag gtg ctt cag gac ctg gta cct gat gat cga aag       1218
Trp Pro Lys Arg Lys Val Leu Gln Asp Leu Val Pro Asp Asp Arg Lys           
            365                 370                 375                   

tta aaa tat act cgt cca ggg ctc cct acc ttc agc cag gaa gta cta       1266
Leu Lys Tyr Thr Arg Pro Gly Leu Pro Thr Phe Ser Gln Glu Val Leu           
        380                 385                 390                       

cat aaa tgg aag aca gat atc aag aaa tat cat cgt att cag tgt cct       1314
His Lys Trp Lys Thr Asp Ile Lys Lys Tyr His Arg Ile Gln Cys Pro           
    395                 400                 405                           

aac cag ggc tgt gag gct gtc tac agc agt gta tct ggc ctt aaa gct       1362
Asn Gln Gly Cys Glu Ala Val Tyr Ser Ser Val Ser Gly Leu Lys Ala           
410                 415                 420                 425           

cac ctg ggc tct tgt aca ttg gga aac ttt gtg gct gga aaa tac aaa       1410
His Leu Gly Ser Cys Thr Leu Gly Asn Phe Val Ala Gly Lys Tyr Lys           
                430                 435                 440               

tgt ctt cta tgt cag aaa gaa ttt gtg tca gag agt ggt gtc aag tat       1458
Cys Leu Leu Cys Gln Lys Glu Phe Val Ser Glu Ser Gly Val Lys Tyr           
            445                 450                 455                   

cac atc aac tcc gtc cat gct gag gac tgg ttc gtt gta aac cca aca       1506
His Ile Asn Ser Val His Ala Glu Asp Trp Phe Val Val Asn Pro Thr           
        460                 465                 470                       

aca acc aaa agc ttt gaa aag ctg atg aag ata aag cag cgg cag caa       1554
Thr Thr Lys Ser Phe Glu Lys Leu Met Lys Ile Lys Gln Arg Gln Gln           
    475                 480                 485                           

gaa gaa gaa aag cgg agg cag cag cac agg agc aga agg tct cta aga       1602
Glu Glu Glu Lys Arg Arg Gln Gln His Arg Ser Arg Arg Ser Leu Arg           
490                 495                 500                 505           

agg cgg cag cag cct ggc att gag ctt ccc gag aca gag ctg agt ctt       1650
Arg Arg Gln Gln Pro Gly Ile Glu Leu Pro Glu Thr Glu Leu Ser Leu           
                510                 515                 520               

aga gta ggg aag gat cag agg agg aat aat gag gaa ctg gta gtg tca       1698
Arg Val Gly Lys Asp Gln Arg Arg Asn Asn Glu Glu Leu Val Val Ser           
            525                 530                 535                   

gcc tcc tgt aag gaa cca gag cag gag cca gtg cca gca cag ttc cag       1746
Ala Ser Cys Lys Glu Pro Glu Gln Glu Pro Val Pro Ala Gln Phe Gln           
        540                 545                 550                       

aaa gta aag ccc cca aag act aat cat aaa cga gga agg aaa tag           1791
Lys Val Lys Pro Pro Lys Thr Asn His Lys Arg Gly Arg Lys                   
    555                 560                 565                           

gcagtcagtg taaaagtgct cctaggaaag cagatgtgat gctgttgtca cggggacctg     1851

tgctgggagg actgagtgaa gattctttca gctgtttgtg taaggctgtg actttctcag     1911

ctccttcctc ctgtgtaaat ttcactgtct tcccttctta cattttgatt cccccctccc     1971

cttttagtag gttttcctgc tattcctcgt caagtcctct tgttttttta tcttgcccaa     2031

agagctccct ctcaaggcca actataggct cctcttgccc tgtacaaaac taagaaacct     2091

ctttggttgt cctttccttc ctggggtata gaatgttctt ggaagctcca ttgatttagt     2151

agctgctcca tcatctagct tgtgaaacca ttccaaacta attttttaaa accataactg     2211

atttgtcatt ttgtatttgt gatataacaa gtctagaagt tagaactgtt gtcattcaca     2271

taataagatt actctgtctc cttgggaaaa aaactttatg gaggctgttt gtcctctcaa     2331

tatggtttta agattgaaag taagaaaacg gatttaggat gaaaactcta gaactaccct     2391

atgctgttta tactgggaaa tgctttgtac caagtagcag tgactagacc cacagacatg     2451

aaaagcaacc ttaggagtaa agtgacccaa acattaaaat gacaggaaag agaaagtaga     2511

agcagcaata aatactgccc caactttcct ggagcccgag gcctcatcca tagctatgat     2571

cacttgccct ctgaagctta tttttgcttc tttggtttta agaattgaga aatatcacat     2631

tgcccctgat gttttgacag tctcctagtg ctcctggtag tgccactaag ggaaaaccaa     2691

ggtgcgcatt ccttctccct ggactttacc ttacttgtta gtctacgccc cactgtttcc     2751

acccatcccc ttagccaacc tctgtctttt tgaattttct gagaatattg tcctatcctc     2811

ttttatatat ggagttctct cctctttata tcctgagact ttgacaccag atgtagatat     2871

ttatctggag ctggaaagaa aaattctttt tctgtacctc atgcctatct ggtaatgttt     2931

aatgggttat ttctctttga gggtggcttt ctctggaaca ttggttagag cagctttgtt     2991

gtcgtgtttc tggattctct tccccatttt gcgtaaatat tggtcttata tattcttgcc     3051

tattttgtgg catatgccac ataaaaaatg aacctgatat agacaagtac taccttttca     3111

aattctgaaa ggctattacc actttaactc tttgtgctcc tccaaatagc tttaaaatgt     3171

gggcttttgt gaagaccact ttcaaacaag ggagcactga aacctgaatt ggatactgcc     3231

agaataggta gttttgaaac aagttaagga catggtatat gcactctgca ttttcattgg     3291

cagtgtgccc ttaaagccct ttcagtagat gagggttgtc agggaggaga aatgaagaag     3351

ctatgttaat ttctggtgag taagacctgg ggaatgtttg gcaatgacaa aagaaataaa     3411

tgactctcag aaagaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                 3460


<210>  448
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  448

Met Ser Ser Arg Leu Gly Ala Val Pro Ala Thr Ser Gly Pro Thr Thr 
1               5                   10                  15      


Phe Lys Gln Gln Arg Ser Thr Arg Ile Val Gly Ala Lys Asn Ser Arg 
            20                  25                  30          


Thr Gln Cys Ser Ile Lys Asp Asn Ser Phe Gln Tyr Thr Ile Pro His 
        35                  40                  45              


Asp Asp Ser Leu Ser Gly Ser Ser Ser Ala Ser Ser Cys Glu Pro Val 
    50                  55                  60                  


Ser Asp Phe Pro Ala Ser Phe Arg Lys Ser Thr Tyr Trp Met Lys Met 
65                  70                  75                  80  


Arg Arg Ile Lys Pro Ala Ala Thr Ser His Val Glu Gly Ser Gly Gly 
                85                  90                  95      


Val Ser Ala Lys Gly Lys Arg Lys Pro Arg Gln Glu Glu Asp Glu Asp 
            100                 105                 110         


Tyr Arg Glu Phe Pro Gln Lys Lys His Lys Leu Tyr Gly Arg Lys Gln 
        115                 120                 125             


Arg Pro Lys Thr Gln Pro Asn Pro Lys Ser Gln Ala Arg Arg Ile Arg 
    130                 135                 140                 


Lys Glu Pro Pro Val Tyr Ala Ala Gly Ser Leu Glu Glu Gln Trp Tyr 
145                 150                 155                 160 


Leu Glu Ile Val Asp Lys Gly Ser Val Ser Cys Pro Thr Cys Gln Ala 
                165                 170                 175     


Val Gly Arg Lys Thr Ile Glu Gly Leu Lys Lys His Met Glu Asn Cys 
            180                 185                 190         


Lys Gln Glu Met Phe Thr Cys His His Cys Gly Lys Gln Leu Arg Ser 
        195                 200                 205             


Leu Ala Gly Met Lys Tyr His Val Met Ala Asn His Asn Ser Leu Pro 
    210                 215                 220                 


Ile Leu Lys Ala Gly Asp Glu Ile Asp Glu Pro Ser Glu Arg Glu Arg 
225                 230                 235                 240 


Leu Arg Thr Val Leu Lys Arg Leu Gly Lys Leu Arg Cys Met Arg Glu 
                245                 250                 255     


Ser Cys Ser Ser Ser Phe Thr Ser Ile Met Gly Tyr Leu Tyr His Val 
            260                 265                 270         


Arg Lys Cys Gly Lys Gly Ala Ala Glu Leu Glu Lys Met Thr Leu Lys 
        275                 280                 285             


Cys His His Cys Gly Lys Pro Tyr Arg Ser Lys Ala Gly Leu Ala Tyr 
    290                 295                 300                 


His Leu Arg Ser Glu His Gly Pro Ile Ser Phe Phe Pro Glu Ser Gly 
305                 310                 315                 320 


Gln Pro Glu Cys Leu Lys Glu Met Asn Leu Glu Ser Lys Ser Gly Gly 
                325                 330                 335     


Arg Val Gln Arg Arg Ser Ala Lys Ile Ala Val Tyr His Leu Gln Glu 
            340                 345                 350         


Leu Ala Ser Ala Glu Leu Ala Lys Glu Trp Pro Lys Arg Lys Val Leu 
        355                 360                 365             


Gln Asp Leu Val Pro Asp Asp Arg Lys Leu Lys Tyr Thr Arg Pro Gly 
    370                 375                 380                 


Leu Pro Thr Phe Ser Gln Glu Val Leu His Lys Trp Lys Thr Asp Ile 
385                 390                 395                 400 


Lys Lys Tyr His Arg Ile Gln Cys Pro Asn Gln Gly Cys Glu Ala Val 
                405                 410                 415     


Tyr Ser Ser Val Ser Gly Leu Lys Ala His Leu Gly Ser Cys Thr Leu 
            420                 425                 430         


Gly Asn Phe Val Ala Gly Lys Tyr Lys Cys Leu Leu Cys Gln Lys Glu 
        435                 440                 445             


Phe Val Ser Glu Ser Gly Val Lys Tyr His Ile Asn Ser Val His Ala 
    450                 455                 460                 


Glu Asp Trp Phe Val Val Asn Pro Thr Thr Thr Lys Ser Phe Glu Lys 
465                 470                 475                 480 


Leu Met Lys Ile Lys Gln Arg Gln Gln Glu Glu Glu Lys Arg Arg Gln 
                485                 490                 495     


Gln His Arg Ser Arg Arg Ser Leu Arg Arg Arg Gln Gln Pro Gly Ile 
            500                 505                 510         


Glu Leu Pro Glu Thr Glu Leu Ser Leu Arg Val Gly Lys Asp Gln Arg 
        515                 520                 525             


Arg Asn Asn Glu Glu Leu Val Val Ser Ala Ser Cys Lys Glu Pro Glu 
    530                 535                 540                 


Gln Glu Pro Val Pro Ala Gln Phe Gln Lys Val Lys Pro Pro Lys Thr 
545                 550                 555                 560 


Asn His Lys Arg Gly Arg Lys 
                565         


<210>  449
<211>  4312
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (152)..(1414)

<400>  449
ctgggctggg gccgcggtgg cggcagccgc ggcggcgggc ggcggttgct cgtgcgcggc       60

ggcggcggcg ggtcccgcgg gcggcggggc gctgacggcc gggggcgcgg cggctgcggc      120

gggccgggcg gcgggcggcg agcgggggaa g atg gcg gag ctg ggg aag aag         172
                                   Met Ala Glu Leu Gly Lys Lys            
                                   1               5                      

tac tgc gtg tac tgc ctg gcc gag gtg agc ccg ctg cgc ttc cgc tgc        220
Tyr Cys Val Tyr Cys Leu Ala Glu Val Ser Pro Leu Arg Phe Arg Cys           
        10                  15                  20                        

acc gag tgc cag gac atc gag ctg tgc ccc gag tgc ttc tcg gcc ggc        268
Thr Glu Cys Gln Asp Ile Glu Leu Cys Pro Glu Cys Phe Ser Ala Gly           
    25                  30                  35                            

gcc gag atc ggc cac cac cgc cgc tac cac ggc tac cag ctg gtg gac        316
Ala Glu Ile Gly His His Arg Arg Tyr His Gly Tyr Gln Leu Val Asp           
40                  45                  50                  55            

ggc ggg cgc ttc acg ctc tgg ggg ccc gag gcc gag ggc ggc tgg acc        364
Gly Gly Arg Phe Thr Leu Trp Gly Pro Glu Ala Glu Gly Gly Trp Thr           
                60                  65                  70                

agt cgc gag gag cag ctg ctg ctg gac gcc atc gag cag ttc ggc ttc        412
Ser Arg Glu Glu Gln Leu Leu Leu Asp Ala Ile Glu Gln Phe Gly Phe           
            75                  80                  85                    

gga aac tgg gaa gat atg gct gcc cac gtt ggt gct tcc cgg act ccc        460
Gly Asn Trp Glu Asp Met Ala Ala His Val Gly Ala Ser Arg Thr Pro           
        90                  95                  100                       

caa gag gtg atg gag cat tac gtg agc atg tac atc cac ggg aac ctg        508
Gln Glu Val Met Glu His Tyr Val Ser Met Tyr Ile His Gly Asn Leu           
    105                 110                 115                           

ggg aag gcc tgc atc ccc gac acc atc ccc aac cgc gtg aca gac cac        556
Gly Lys Ala Cys Ile Pro Asp Thr Ile Pro Asn Arg Val Thr Asp His           
120                 125                 130                 135           

acc tgt ccc agc gga ggc ccc ctc tca ccc agc ctc acc acc ccg ctg        604
Thr Cys Pro Ser Gly Gly Pro Leu Ser Pro Ser Leu Thr Thr Pro Leu           
                140                 145                 150               

ccc ccg ctg gac atc tct gtg gct gag cag cag cag ctg ggc tac atg        652
Pro Pro Leu Asp Ile Ser Val Ala Glu Gln Gln Gln Leu Gly Tyr Met           
            155                 160                 165                   

ccg ctg cgg gat gat tac gag atc gag tat gac cag gat gcc gag acg        700
Pro Leu Arg Asp Asp Tyr Glu Ile Glu Tyr Asp Gln Asp Ala Glu Thr           
        170                 175                 180                       

ctc atc agc ggg ctc tct gtc aac tat gat gac gac gac gtg gag atc        748
Leu Ile Ser Gly Leu Ser Val Asn Tyr Asp Asp Asp Asp Val Glu Ile           
    185                 190                 195                           

gag ctg aag cgc gcc cac gtg gac atg tac gtg cgg aag ctg aaa gag        796
Glu Leu Lys Arg Ala His Val Asp Met Tyr Val Arg Lys Leu Lys Glu           
200                 205                 210                 215           

aga cag cgg cgg aag aac atc gcc cgt gac tac aat ctg gtg cca gcc        844
Arg Gln Arg Arg Lys Asn Ile Ala Arg Asp Tyr Asn Leu Val Pro Ala           
                220                 225                 230               

ttc ctg ggg aag gac aag aag gag aag gaa aag gcg ctg aag cgc aag        892
Phe Leu Gly Lys Asp Lys Lys Glu Lys Glu Lys Ala Leu Lys Arg Lys           
            235                 240                 245                   

atc acc aag gag gag aag gag ctg cgc ctg aag ctg agg ccg ctg tac        940
Ile Thr Lys Glu Glu Lys Glu Leu Arg Leu Lys Leu Arg Pro Leu Tyr           
        250                 255                 260                       

cag ttc atg tca tgc aag gag ttt gat gac ctt ttt gaa aac atg cac        988
Gln Phe Met Ser Cys Lys Glu Phe Asp Asp Leu Phe Glu Asn Met His           
    265                 270                 275                           

aaa gaa aaa atg ctc cgg gcc aag atc cga gaa ctg cag cgg tac cgg       1036
Lys Glu Lys Met Leu Arg Ala Lys Ile Arg Glu Leu Gln Arg Tyr Arg           
280                 285                 290                 295           

cga aac ggg atc acc aag atg gaa gag tcg gca gag tac gag gca gcg       1084
Arg Asn Gly Ile Thr Lys Met Glu Glu Ser Ala Glu Tyr Glu Ala Ala           
                300                 305                 310               

cgg cat aaa cgg gag aag agg aag gag aac aaa aac cta gcc ggc tcc       1132
Arg His Lys Arg Glu Lys Arg Lys Glu Asn Lys Asn Leu Ala Gly Ser           
            315                 320                 325                   

aaa cgg gga aag gag gac ggc aaa gac agc gag ttc gcc gcc att gag       1180
Lys Arg Gly Lys Glu Asp Gly Lys Asp Ser Glu Phe Ala Ala Ile Glu           
        330                 335                 340                       

aac ctt cca ggc ttc gag ctc ctg tca gat cgc gag aag gtg ctc tgc       1228
Asn Leu Pro Gly Phe Glu Leu Leu Ser Asp Arg Glu Lys Val Leu Cys           
    345                 350                 355                           

agc tct tta aac ttg agt cca gcc cgc tac gtg act gtg aag act att       1276
Ser Ser Leu Asn Leu Ser Pro Ala Arg Tyr Val Thr Val Lys Thr Ile           
360                 365                 370                 375           

ata att aaa gac cac ctc cag aag cgg caa gga atc ccc tcc aaa agc       1324
Ile Ile Lys Asp His Leu Gln Lys Arg Gln Gly Ile Pro Ser Lys Ser           
                380                 385                 390               

cgc ctt cct agc tac ctg gac aaa gtc cta aag aaa agg att ttg aat       1372
Arg Leu Pro Ser Tyr Leu Asp Lys Val Leu Lys Lys Arg Ile Leu Asn           
            395                 400                 405                   

ttc ctc aca gaa agc ggc tgg atc tcc agg gac gcg tct tga               1414
Phe Leu Thr Glu Ser Gly Trp Ile Ser Arg Asp Ala Ser                       
        410                 415                 420                       

agctgagacg ctttgaaagc cagggtgatg ctcagacagt gtgccagcca aaatgacttg     1474

ggggagggga gccgcttccc cactgttgct cttttttaaa caaattgagt tccttttttt     1534

aagatagaaa ttcttttcat ggtcctctga aagaagcaat agtaacaatc ttatattgga     1594

tcatggggga agcaaatgtg tgtattttaa gtgagttcct gcgagtcata cactgcgatg     1654

atgctccgcc tttacccgtt cagttgggag cttattgtga gattggatca tttccttttg     1714

agtgttcttc tctttggtac aaaagctatt gtgggtgaca ggagcagtgt tttcctgctg     1774

gacccgcaag ccaccagcta tttcctggtg acacaagctc ttctcaggcg gggctgcctg     1834

caggctcccg ttttctgagc ccacgctgcc cacagctgac cccagcgcag ccccgggcac     1894

gcggcacttt acatgggggc agcttgggcc cagactcctc cgctgtgtag cagatgagga     1954

aaatcaggcc agaggacaac aggctggcgt tttgttggga actgaagagg aatctgttga     2014

acacagcgac cagatgacct tccatttcac cggcggcagc agtttcagcg tgcagttccc     2074

aaaccccaaa gctgaccctg cgccccattt gaatacggcc agagcctgct ggttcacttt     2134

gggtagagcc gtgcctcttg ggcaggctcc catagtgacc acgtccccac gaatgggaaa     2194

gcacgttagt gggagggacg taggacacgt gtggaccgcc aggccctctc agtccatttt     2254

ccggggctgc tcggtgctgc tgttaagacg tgagtgcatt tcacttggaa gaacccattg     2314

tacaaagttc aaggctaaga gttctgaatt ctggcgtcag cttcctcagg attttcttca     2374

gttgcaagta cctttccact gaaaatatga gcatgcccgc ctggctagta ggcatctgta     2434

agagtgtcgc caggcccgcg ccagctgagg cctcagacta gccaggcaag agccgtctga     2494

ccagttggct ggcggtggtt ctggtggagc acgagggagc ccgggtggtg ccctgagcct     2554

cgagctgctc tctgtcactg tcttgaatca gactcagaaa tggcttcttc ccagccctgc     2614

ctacaagttt ttctctgggg tcctctttca aggatgtcca cggtaccttc ctcctgaaac     2674

ttgaggaagt cttttgtctt ccagctgctc agggttctct ggtccaagac cctgctttaa     2734

agagagtctt tggcgtgctc agactccagc gctccgttct tcaaggaggt tgacttgcct     2794

ctcgggcccc gtaggtacca agagactgtt tacctcccag aatgtttggg cttgaagtta     2854

cattaaagtg aagttatttg aaagaaagaa aacctcatca tttctaagga tgacttaatt     2914

actgtgcctt ttcctttctt tttacacatc ctactgtccc ttagggtaaa attttcagca     2974

ttaaataaaa catttcaaat atattgtata tggctttagt tgtaaactat actgcatgct     3034

gacagagaag cgctctttta gctaagccca gaacttctct tttgacaata aagtactgag     3094

cagtggtatc atgagggcca cctccacatt gtcccctgca gaataaatgc ggatgacaga     3154

aagcttatgc tgtctaccac tgaacagtga tggagatggt gctaagtttt tacagttgtc     3214

ttagccccag tggttctcaa ggtggggctc ctggcccagc agcagcaact tgtttgttag     3274

aatgcagacg cgcaggcccc acctggcctc ctgaatcaaa atggtgtgcg gcagggtgca     3334

gcgagctgtt ttcacgaggc ctccaggtga ctggatgtaa gcttgcttga gaactatggg     3394

ttttagctat tctggtgtct ccctgatttt ctacagcgcc aggatcctag tttggtgagg     3454

ttttaaattt aatcttattt ttatataaaa tgattgccag acgtactata ttaagcttga     3514

agaagcagaa gatccctgtt aatgtgtatg gcccaggcca agagctgtca aatgaaaaac     3574

tttgtgctga agcaggtttt tagtatgtat atctttttga tggtatgaag aatttattta     3634

ggcttgactg ttttaaaaca ccataatgaa tgtataatta atttatgtta aagtattaac     3694

cctttgtcac aaaggaatgg taatgtgatt ggctgcctgt tagcccatcg actattcccg     3754

tcacggtagt ccttacctct gtcggcagct cagagcctcc acatttttat atttaattct     3814

catgataaat tagccaccat aatcccatgg aattaggtct tgttaaaatc tagtccgggc     3874

gcagtggctc acgcctgtaa tcccagcact ttgggaggcc aaggcgggct gatcacgagg     3934

tcaagagatc gagaccatcc tggccaacat ggtgaaaccc tgtctctact aaaaatacaa     3994

aaattagctg ggtgtggtgg tgcatgcctg tagtcccagc tacttgggag gctgaggtag     4054

gagaattgct tgaacctggg aggcggaggt tgcggtgagc tgagatcacg ccactacact     4114

ccagcctggt gacagagcaa gactccatct caaaaaaaat ctaagcaaac tatctttgag     4174

tcaaaaaaag ttggataact catctatatt tgaaataatg ctgtctgaat ggccaacatc     4234

ccaagaatgt attaaaaaca gcaaccctgc ctaccgtttt gatgaccttt ttccatatta     4294

aacaagttga gaacaaaa                                                   4312


<210>  450
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  450

Met Ala Glu Leu Gly Lys Lys Tyr Cys Val Tyr Cys Leu Ala Glu Val 
1               5                   10                  15      


Ser Pro Leu Arg Phe Arg Cys Thr Glu Cys Gln Asp Ile Glu Leu Cys 
            20                  25                  30          


Pro Glu Cys Phe Ser Ala Gly Ala Glu Ile Gly His His Arg Arg Tyr 
        35                  40                  45              


His Gly Tyr Gln Leu Val Asp Gly Gly Arg Phe Thr Leu Trp Gly Pro 
    50                  55                  60                  


Glu Ala Glu Gly Gly Trp Thr Ser Arg Glu Glu Gln Leu Leu Leu Asp 
65                  70                  75                  80  


Ala Ile Glu Gln Phe Gly Phe Gly Asn Trp Glu Asp Met Ala Ala His 
                85                  90                  95      


Val Gly Ala Ser Arg Thr Pro Gln Glu Val Met Glu His Tyr Val Ser 
            100                 105                 110         


Met Tyr Ile His Gly Asn Leu Gly Lys Ala Cys Ile Pro Asp Thr Ile 
        115                 120                 125             


Pro Asn Arg Val Thr Asp His Thr Cys Pro Ser Gly Gly Pro Leu Ser 
    130                 135                 140                 


Pro Ser Leu Thr Thr Pro Leu Pro Pro Leu Asp Ile Ser Val Ala Glu 
145                 150                 155                 160 


Gln Gln Gln Leu Gly Tyr Met Pro Leu Arg Asp Asp Tyr Glu Ile Glu 
                165                 170                 175     


Tyr Asp Gln Asp Ala Glu Thr Leu Ile Ser Gly Leu Ser Val Asn Tyr 
            180                 185                 190         


Asp Asp Asp Asp Val Glu Ile Glu Leu Lys Arg Ala His Val Asp Met 
        195                 200                 205             


Tyr Val Arg Lys Leu Lys Glu Arg Gln Arg Arg Lys Asn Ile Ala Arg 
    210                 215                 220                 


Asp Tyr Asn Leu Val Pro Ala Phe Leu Gly Lys Asp Lys Lys Glu Lys 
225                 230                 235                 240 


Glu Lys Ala Leu Lys Arg Lys Ile Thr Lys Glu Glu Lys Glu Leu Arg 
                245                 250                 255     


Leu Lys Leu Arg Pro Leu Tyr Gln Phe Met Ser Cys Lys Glu Phe Asp 
            260                 265                 270         


Asp Leu Phe Glu Asn Met His Lys Glu Lys Met Leu Arg Ala Lys Ile 
        275                 280                 285             


Arg Glu Leu Gln Arg Tyr Arg Arg Asn Gly Ile Thr Lys Met Glu Glu 
    290                 295                 300                 


Ser Ala Glu Tyr Glu Ala Ala Arg His Lys Arg Glu Lys Arg Lys Glu 
305                 310                 315                 320 


Asn Lys Asn Leu Ala Gly Ser Lys Arg Gly Lys Glu Asp Gly Lys Asp 
                325                 330                 335     


Ser Glu Phe Ala Ala Ile Glu Asn Leu Pro Gly Phe Glu Leu Leu Ser 
            340                 345                 350         


Asp Arg Glu Lys Val Leu Cys Ser Ser Leu Asn Leu Ser Pro Ala Arg 
        355                 360                 365             


Tyr Val Thr Val Lys Thr Ile Ile Ile Lys Asp His Leu Gln Lys Arg 
    370                 375                 380                 


Gln Gly Ile Pro Ser Lys Ser Arg Leu Pro Ser Tyr Leu Asp Lys Val 
385                 390                 395                 400 


Leu Lys Lys Arg Ile Leu Asn Phe Leu Thr Glu Ser Gly Trp Ile Ser 
                405                 410                 415     


Arg Asp Ala Ser 
            420 


<210>  451
<211>  5904
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (300)..(1553)

<400>  451
agcgggactg agcgccggga gagacctgcg caggcgcagg cgcgcgggaa gggccagcct       60

gggtggccca ccccgcgcct ggcgggactg gccgccaact cccctccgct ccagtcactt      120

gtctggagct tgaagaagtg ggtattcccc ttcccacccc aggcactgga ggagcggccc      180

cccggggatt ccaggacctg agctccggga gctggactcg cagcgaccgc ggcagagcga      240

gcgggcgccg ggaagcgagg agacgcccgc gggaggccca gctgctcgga gcaactggc       299

atg gcc cga gcc atg gcc gcc gcg tgg ccg ctg ctg ctg gtg gcg cta        347
Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu           
1               5                   10                  15                

ctg gtg ctg tcc tgg cca ccc cca gga acc ggg gac gtc gtc gtg cag        395
Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln           
            20                  25                  30                    

gcg ccc acc cag gtg ccc ggc ttc ttg ggc gac tcc gtg acg ctg ccc        443
Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro           
        35                  40                  45                        

tgc tac cta cag gtg ccc aac atg gag gtg acg cat gtg tca cag ctg        491
Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu           
    50                  55                  60                            

act tgg gcg cgg cat ggt gaa tct ggc agc atg gcc gtc ttc cac caa        539
Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln           
65                  70                  75                  80            

acg cag ggc ccc agc tat tcg gag tcc aaa cgg ctg gaa ttc gtg gca        587
Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala           
                85                  90                  95                

gcc aga ctg ggc gcg gag ctg cgg aat gcc tcg ctg agg atg ttc ggg        635
Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly           
            100                 105                 110                   

ttg cgc gta gag gat gaa ggc aac tac acc tgc ctg ttc gtc acg ttc        683
Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe           
        115                 120                 125                       

ccg cag ggc agc agg agc gtg gat atc tgg ctc cga gtg ctt gcc aag        731
Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys           
    130                 135                 140                           

ccc cag aac aca gct gag gtt cag aag gtc cag ctc act gga gag cca        779
Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro           
145                 150                 155                 160           

gtg ccc atg gcc cgc tgc gtc tcc aca ggg ggt cgc ccg cca gcc caa        827
Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln           
                165                 170                 175               

atc acc tgg cac tca gac ctg ggc ggg atg ccc aat acg agc cag gtg        875
Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val           
            180                 185                 190                   

cca ggg ttc ctg tct ggc aca gtc act gtc acc agc ctc tgg ata ttg        923
Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu           
        195                 200                 205                       

gtg ccc tca agc cag gtg gac ggc aag aat gtg acc tgc aag gtg gag        971
Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu           
    210                 215                 220                           

cac gag agc ttt gag aag cct cag ctg ctg act gtg aac ctc acc gtg       1019
His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val           
225                 230                 235                 240           

tac tac ccc cca gag gta tcc atc tct ggc tat gat aac aac tgg tac       1067
Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr           
                245                 250                 255               

ctt ggc cag aat gag gcc acc ctg acc tgc gat gct cgc agc aac cca       1115
Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro           
            260                 265                 270                   

gag ccc aca ggc tat aat tgg agc acg acc atg ggt ccc ctg cca ccc       1163
Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro           
        275                 280                 285                       

ttt gct gtg gcc cag ggc gcc cag ctc ctg atc cgt cct gtg gac aaa       1211
Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys           
    290                 295                 300                           

cca atc aac aca act tta atc tgc aac gtc acc aat gcc cta gga gct       1259
Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala           
305                 310                 315                 320           

cgc cag gca gaa ctg acc gtc cag gtc aaa gag gga cct ccc agt gag       1307
Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu           
                325                 330                 335               

cac tca ggc ata tcc cgt aac gcc atc atc ttc ctg gtt ctg gga atc       1355
His Ser Gly Ile Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile           
            340                 345                 350                   

ctg gtt ttt ctg atc ctg ctg ggg atc ggg att tat ttc tat tgg tcc       1403
Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser           
        355                 360                 365                       

aaa tgt tcc cgt gag gtc ctt tgg cac tgt cat ctg tgt ccc tcg agt       1451
Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser           
    370                 375                 380                           

aca gag cat gcc agc gcc tca gct aat ggg cat gtc tcc tat tca gct       1499
Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala           
385                 390                 395                 400           

gtg agc aga gag aac agc tct tcc cag gat cca cag aca gag ggc aca       1547
Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr           
                405                 410                 415               

agg tga cagcgtcggg actgagaggg gagagagact ggagctggca aggacgtggg        1603
Arg                                                                       
                                                                          

cctccagagt tggacccgac cccaatggat gaagaccccc tccaaagaga ccagcctccc     1663

tccctgtgcc agacctcaaa acgacggggg caggtgcaag ttcataggtc tccaagacca     1723

ccctcctttc atttgctaga aggactcact agactcagga aagctgttag gctcacagtt     1783

acagtttatt acagtaaaag gacagagatt aagatcagca aagggaggag gtgcacagca     1843

cacgttccac gacagatgag gcgacggctt ccatctgccc tctcccagtg gagccatata     1903

ggcagcacct gattctcaca gcaacatgtg acaacatgca agaagtactg ccaatactgc     1963

caaccagagc agctcactcg agatctttgt gtccagagtt ttttgtttgt cttgagacag     2023

ggtctggctc tgttggcaga ctagagtaca gtggtgagat cacagttcat tgcagccttg     2083

acttctcaac gccaagtcat cctcccacct cagcctcctg agtagctatg actacaggta     2143

tgtgccacca cgtctggcta atctttttat tatttgtaaa gtcgaggttt ccctgtgttg     2203

cccaggctgg tcttgaactc ttggctccaa gtgatacttc tgccttggcc tcccaaagtg     2263

ctgaattaag cagctcacca tccacacggc tgacctcata catcaagcca ataccgtgtg     2323

gcccaagacc cccaccataa atcacatcat tagcatgaac cacccagagt ggcccaagac     2383

tcccagatca gctaccaggc aggatattcc aagggcttag agatgaatgc ccaggagctg     2443

aggataaagg gcccgatctt tctttgggca aggttaagcc tttactgcat agcagaccac     2503

acagaagggt gtgggccacc agagaatttt ggtaaaaatt tggcctctgg ccttgagctt     2563

ctaaatctct gtatccgtca gatctctgtg gttacaagaa acagccactg accctggtca     2623

ccagaggctg caattcaggc cgcaagcagc tgcctggggg gtgtccaagg agcagagaaa     2683

actactagat gtgaacttga agaaggttgt cagctgcagc cactttctgc cagcatctgc     2743

agccactttc tgccagcatc tgcagccagc aagctgggac tggcaggaaa taacccacaa     2803

aagaagcaaa tgcaatttcc aacacaaggg ggaagggatg cagggggagg cagcgctgca     2863

gttgctcagg acacgctcct ataggaccaa gatggatgcg acccaagacc caggaggccc     2923

agctgctcag tgcaactgac aagttaaaaa ggtctatgat cttgagggca gacagcagaa     2983

ttcctcttat aaagaaaact gtttgggaaa atacgttgag ggagagaaga ccttgggcca     3043

agatgctaaa tgggaatgca aagcttgagc tgctctgcaa gagaaaataa gcaggacaga     3103

ggatttgctc tggacagaga tggaagagcc gggaacagag aagtgtgggg aagagatagg     3163

aaccagcagg atggcagggg caaagggctc aagggtgagg aggccagtgg gaccccacag     3223

agttggggag ataaaggaac attggttgct ttggtggcac gtaagctcct tgtctgtctc     3283

cagcacccag aatctcatta aagcttattt attgtacctc cagcggctgt gtgcaatggg     3343

gtcttttgtg gaaatcaagg agcagacagg tttcatgtgt actgtcacca cgtgggatgg     3403

aaccagaggc atggaagcaa gacgctaaat gaagagggcc ataagggctg ggattcccag     3463

gcaccttagg aacagcttgt cttttttttt ttcctctcca aaaaaaatgt ttaagggacg     3523

gtgtctcctg tcacccaggc tggagtgcaa tggcacgatc atagctcatt gcagcctcta     3583

actccggggc tcaagcaatc ctcccacctc agcctaccaa gtagctgtga ccacagctgc     3643

ccctcaccat gctaagctaa tttttttaat tagatagtac ataaacgtcc caaaattaga     3703

agataaaaag acatgaggga tccattctaa tttgtgtttg gagtgtaatg gtccagctcc     3763

attcttctgc acatggatat ccagttttac acaacactgt gaatgtaatg aatgccactg     3823

aatcatacac tcaaaaatag ctaaaatggc aaattgtctg ttatctcttt ttaaccacca     3883

tttttgaaaa ttaattatac caaaaaacca ttgaatagtg cactttattt atttatttat     3943

ttgtttattt atttatttat tttagaaata agagtctcac tttgttgccc aggctggagt     4003

gcggtggcgt gatcatggct cattgcagcc tcgacctgct gggctcgggc tatccttcca     4063

tctcagcctc ccgagtagct gggactatag gtgggcgcca ccccacctgg ctaaatctct     4123

ttttaacttt tgtagagata ggcatctcgc tatgttgcct aggctgggct ggaactcctg     4183

ggctcaagtg ctcctcctgc cttggcctcc caaagcgcta ggattacaga tgtgagccac     4243

cgcgcccacc ctgaacctta ctttttttgc tcagtttctg gtaattcaga gaatgcctcc     4303

tgagttgttc tacacccacc tcatattcca tgggagggct gtacagggct tttttaacga     4363

ggcctctaag gacaggcatt tgtatccttt ccagcctttc actattacaa tgttgtagtg     4423

aataacttta cacactgtca tttattttac tttttttttt ttttatttta gagaaaggaa     4483

tcttgccatc ttgcccaggc tggtctcaaa ttcctgggcc caaacaatcc tcccgccttg     4543

gcctcctaaa gtactgggat ttataggcat aagccaccgt gcctggccaa tgcacactgt     4603

catttagctc atgttaacac ctgagtgtag gacacactcc tggaggtgga attgctgggc     4663

caaagagtat gtttcttgtc attgtgatag atattgacaa atgaaccctc acagaagttg     4723

tgctgagttc tgttcccacc agcgacgtag gcgatgacct ttttctggag ggagggggca     4783

tccttggagt ccacagagcc aggaatggag agtgggccca gaattttggt ataggtgttg     4843

tataaactta tagtaaggtt aagaaaaccg ccactatcct tatcagagac ttggcggggg     4903

gcagggtatg atggagatca taaggaggct aaaacactcc acaccctccc tctgcattgc     4963

tcctgcacag gagtcgggaa tcttttcagg ttgatacgat ctcaccttga ggagctgtga     5023

ggtcccagaa gcctctgggt tgcagattgc ttggggtgaa aatgtctgtg ctactgaaat     5083

ctaacttttt acaaaaaatt acgggctggg cgcagtggct cacgcctgta atcccagcac     5143

tttgggaggc tgcagcgggt ggatcacttg aggtaaggag ttcaagacca gaccatagtg     5203

aaaccgtgtc tctacaaaaa aaattagcca ggtgtggtgg tgcatgcttg taatcccagc     5263

tactcagaag gctgaggtgg gagaatccct tgaacccggg aagtggaggc tggagtaaac     5323

catgatcgag ttactgcact ccagcctggg tgacaagagt gagactctgt ctccaaaaaa     5383

aaaaaaaaaa aaaaaaaaaa ctggattgcc tggctctact ccgggcacag catgcaggcc     5443

cagttctgct gctctgctgt ttgttctgct ttcctccaca tattggcatc accctctggt     5503

gccaagatgg ctgctgcatt ccaggcatca catccagact cagacccaga gaagctgccc     5563

atccctacct gggtgagcct ttgtaggaac gagaaaccgc atccagcagc agaaacctca     5623

cccagcagcg tcttttccgg tctcattcac cagcgccgcc caccgctcaa ccaatccctg     5683

gccaaaagaa tgggaccgcc tggaaggctg gaccaaacag gacctgccct ctggggctgg     5743

ggagaggccc agatgaaggc tgcaggacag gatggactcc tagacctctg ttaccagcag     5803

tgactacctc tgtctgggtg gttggaacat gtttgaattt tattctaagt actgtctaca     5863

agttctgcaa taaaccttga ctcttctttt aataatgcaa a                         5904


<210>  452
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  452

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Ile Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
            340                 345                 350         


Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
        355                 360                 365             


Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
    370                 375                 380                 


Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala 
385                 390                 395                 400 


Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr 
                405                 410                 415     


Arg 
    


<210>  453
<211>  1535
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (571)..(1230)

<400>  453
cggccgccat cttggcccaa ctgctcccct cactccagtt gctcagcccg ccgctgagca       60

cagccaatcc gcggccgtcc actcactgtt tcggccaatc accgagcaga cggcccggaa      120

gctcgagagg ctcgtgccag gtcggggggc gaaggcgagg ccagaccacc aagcaggggc      180

gtcaccaagg gaaagccaat caccattatt tctgaagccc aagggggcgg gacgagaagt      240

caacataatg gtggtgctgc tggaaatcta gcacctgggg agagcctgag acttgtgtat      300

ctaattgcct attggacacc tccatctggg taaacccagg catccagaac tttccctcaa      360

gacttacctc cctcagtgca ggtcgggctg gcctcacgca tttcgcttgg atgcctaaat      420

ctgtctccac gtggggccgg tcgataaaac aacacttccc agaatacgct gcgatccatt      480

cgcggtctgc acccggaaag tacacctccc aggggtctgt gcgcgcctcc agggaacggg      540

tcttgtggct ttgtctcccg cgaagaggag atg gcg gag tcg ttg agg tct ccg       594
                                 Met Ala Glu Ser Leu Arg Ser Pro          
                                 1               5                        

cgc cgc tcc ctg tac aaa ctg gtg ggc tcg ccg cct tgg aaa gag gct        642
Arg Arg Ser Leu Tyr Lys Leu Val Gly Ser Pro Pro Trp Lys Glu Ala           
    10                  15                  20                            

ttc cgg cag aga tgc ctg gag aga atg aga aac agc cgg gac agg ctc        690
Phe Arg Gln Arg Cys Leu Glu Arg Met Arg Asn Ser Arg Asp Arg Leu           
25                  30                  35                  40            

cta aac agg tac cgc cag gct gga agc agt ggg cca ggg aat tct cag        738
Leu Asn Arg Tyr Arg Gln Ala Gly Ser Ser Gly Pro Gly Asn Ser Gln           
                45                  50                  55                

aac agc ttt cta gtt caa gag gtg atg gaa gaa gag tgg aat gct ttg        786
Asn Ser Phe Leu Val Gln Glu Val Met Glu Glu Glu Trp Asn Ala Leu           
            60                  65                  70                    

cag tca gtg gag aat tgt cca gaa gac ttg gct cag ctg gag gag ctg        834
Gln Ser Val Glu Asn Cys Pro Glu Asp Leu Ala Gln Leu Glu Glu Leu           
        75                  80                  85                        

ata gac atg gct gtg ctg gag gaa att caa cag gag ctg atc aag caa        882
Ile Asp Met Ala Val Leu Glu Glu Ile Gln Gln Glu Leu Ile Lys Gln           
    90                  95                  100                           

gag cag tcc atc atc agc gag tat gag aag agc ttg cag ttt gat gaa        930
Glu Gln Ser Ile Ile Ser Glu Tyr Glu Lys Ser Leu Gln Phe Asp Glu           
105                 110                 115                 120           

aag tgt ctc agc atc atg ctg gct gag tgg gag gca aac cca ctc atc        978
Lys Cys Leu Ser Ile Met Leu Ala Glu Trp Glu Ala Asn Pro Leu Ile           
                125                 130                 135               

tgt cct gta tgt aca aag tac aac ctg aga atc aca agc ggt gtg gtg       1026
Cys Pro Val Cys Thr Lys Tyr Asn Leu Arg Ile Thr Ser Gly Val Val           
            140                 145                 150                   

gtg tgt cag tgt ggc ctg tcc atc cca tct cat tct tct gag ttg aca       1074
Val Cys Gln Cys Gly Leu Ser Ile Pro Ser His Ser Ser Glu Leu Thr           
        155                 160                 165                       

gag cag aag ctt cgt gcc tgt tta gag ggt agt ata aat gag cac agt       1122
Glu Gln Lys Leu Arg Ala Cys Leu Glu Gly Ser Ile Asn Glu His Ser           
    170                 175                 180                           

gca cat tgt ccc cac aca cct gaa ttt tca gtc act gga gga aca gaa       1170
Ala His Cys Pro His Thr Pro Glu Phe Ser Val Thr Gly Gly Thr Glu           
185                 190                 195                 200           

gaa aag tcc agt ctt ctc atg agc tgt ctg gcc tgt gat act tgg gct       1218
Glu Lys Ser Ser Leu Leu Met Ser Cys Leu Ala Cys Asp Thr Trp Ala           
                205                 210                 215               

gtg atc ctc tag agccagcttg gactcacatc attctatggg gttgaagaca           1270
Val Ile Leu                                                               
                                                                          

actcattccc tctgaggagc cttgtacata caagcctttt atttataact tattttgtat     1330

tgaaactttt aaacaatact gaagaaaaaa aaacttttcc gacatctgtt cttggtcttt     1390

tgtgacgcag gttgaagggg gaggaataga aaaagacaaa ctgccttgga ggagataaac     1450

caattttatg tctatcatgt tatacaaaaa tctagaaata atagatttgt acagaaaaaa     1510

atgataataa atgagaacac aaaac                                           1535


<210>  454
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  454

Met Ala Glu Ser Leu Arg Ser Pro Arg Arg Ser Leu Tyr Lys Leu Val 
1               5                   10                  15      


Gly Ser Pro Pro Trp Lys Glu Ala Phe Arg Gln Arg Cys Leu Glu Arg 
            20                  25                  30          


Met Arg Asn Ser Arg Asp Arg Leu Leu Asn Arg Tyr Arg Gln Ala Gly 
        35                  40                  45              


Ser Ser Gly Pro Gly Asn Ser Gln Asn Ser Phe Leu Val Gln Glu Val 
    50                  55                  60                  


Met Glu Glu Glu Trp Asn Ala Leu Gln Ser Val Glu Asn Cys Pro Glu 
65                  70                  75                  80  


Asp Leu Ala Gln Leu Glu Glu Leu Ile Asp Met Ala Val Leu Glu Glu 
                85                  90                  95      


Ile Gln Gln Glu Leu Ile Lys Gln Glu Gln Ser Ile Ile Ser Glu Tyr 
            100                 105                 110         


Glu Lys Ser Leu Gln Phe Asp Glu Lys Cys Leu Ser Ile Met Leu Ala 
        115                 120                 125             


Glu Trp Glu Ala Asn Pro Leu Ile Cys Pro Val Cys Thr Lys Tyr Asn 
    130                 135                 140                 


Leu Arg Ile Thr Ser Gly Val Val Val Cys Gln Cys Gly Leu Ser Ile 
145                 150                 155                 160 


Pro Ser His Ser Ser Glu Leu Thr Glu Gln Lys Leu Arg Ala Cys Leu 
                165                 170                 175     


Glu Gly Ser Ile Asn Glu His Ser Ala His Cys Pro His Thr Pro Glu 
            180                 185                 190         


Phe Ser Val Thr Gly Gly Thr Glu Glu Lys Ser Ser Leu Leu Met Ser 
        195                 200                 205             


Cys Leu Ala Cys Asp Thr Trp Ala Val Ile Leu 
    210                 215                 


<210>  455
<211>  1633
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1506)

<400>  455
atg tgg aag ctt tgg aga gct gaa gag ggc gcg gcg gcg ctc ggc ggc         48
Met Trp Lys Leu Trp Arg Ala Glu Glu Gly Ala Ala Ala Leu Gly Gly           
1               5                   10                  15                

gcg ctc ttc ctg ctg ctc ttc gcg cta ggg gtc cgc cag ctg ctg aag         96
Ala Leu Phe Leu Leu Leu Phe Ala Leu Gly Val Arg Gln Leu Leu Lys           
            20                  25                  30                    

cag agg cgg ccg atg ggc ttc ccc ccg ggg ccg ccg ggg ctg cca ttt        144
Gln Arg Arg Pro Met Gly Phe Pro Pro Gly Pro Pro Gly Leu Pro Phe           
        35                  40                  45                        

atc ggc aac atc tat tcc ctg gca gcc tca tcc gag ctt ccc cat gtc        192
Ile Gly Asn Ile Tyr Ser Leu Ala Ala Ser Ser Glu Leu Pro His Val           
    50                  55                  60                            

tac atg aga aag cag agc cag gtg tac gga gag atc ttc agt tta gat        240
Tyr Met Arg Lys Gln Ser Gln Val Tyr Gly Glu Ile Phe Ser Leu Asp           
65                  70                  75                  80            

ctt gga ggc ata tca act gtg gtt cta aat ggc tat gat gta gta aag        288
Leu Gly Gly Ile Ser Thr Val Val Leu Asn Gly Tyr Asp Val Val Lys           
                85                  90                  95                

gaa tgc ctt gtt cat caa agc gaa att ttt gca gac aga cca tgc ctt        336
Glu Cys Leu Val His Gln Ser Glu Ile Phe Ala Asp Arg Pro Cys Leu           
            100                 105                 110                   

cct tta ttc atg aag atg aca aaa atg gga ggc tta ctc aat tcc aga        384
Pro Leu Phe Met Lys Met Thr Lys Met Gly Gly Leu Leu Asn Ser Arg           
        115                 120                 125                       

tat ggc cga gga tgg gtt gat cac aga cga tta gct gta aac agt ttt        432
Tyr Gly Arg Gly Trp Val Asp His Arg Arg Leu Ala Val Asn Ser Phe           
    130                 135                 140                           

cga tat ttt gga tat ggc caa aag tct ttt gaa tct aaa atc ttg gaa        480
Arg Tyr Phe Gly Tyr Gly Gln Lys Ser Phe Glu Ser Lys Ile Leu Glu           
145                 150                 155                 160           

gaa acc aaa ttt ttc aat gat gct att gaa aca tac aaa ggt aga cct        528
Glu Thr Lys Phe Phe Asn Asp Ala Ile Glu Thr Tyr Lys Gly Arg Pro           
                165                 170                 175               

ttt gac ttt aaa cag tta ata acg aat gct gtt tca aac ata acc aat        576
Phe Asp Phe Lys Gln Leu Ile Thr Asn Ala Val Ser Asn Ile Thr Asn           
            180                 185                 190                   

ctg atc att ttt gga gaa cga ttc act tat gaa gac acc gat ttt cag        624
Leu Ile Ile Phe Gly Glu Arg Phe Thr Tyr Glu Asp Thr Asp Phe Gln           
        195                 200                 205                       

cac atg att gag tta ttt agt gaa aat gtg gaa cta gct gcc agt gcc        672
His Met Ile Glu Leu Phe Ser Glu Asn Val Glu Leu Ala Ala Ser Ala           
    210                 215                 220                           

tca gtc ttc ttg tat aat gcc ttt cca tgg att ggc atc ctg cct ttt        720
Ser Val Phe Leu Tyr Asn Ala Phe Pro Trp Ile Gly Ile Leu Pro Phe           
225                 230                 235                 240           

gga aaa cat caa cag ctg ttt aga aat gca gct gta gtc tat gat ttt        768
Gly Lys His Gln Gln Leu Phe Arg Asn Ala Ala Val Val Tyr Asp Phe           
                245                 250                 255               

ctc tcc aga ctc att gaa aaa gct tca gtc aac aga aag cct cag cta        816
Leu Ser Arg Leu Ile Glu Lys Ala Ser Val Asn Arg Lys Pro Gln Leu           
            260                 265                 270                   

cct cag cat ttt gtt gat gct tat tta gat gag atg gat caa ggt aaa        864
Pro Gln His Phe Val Asp Ala Tyr Leu Asp Glu Met Asp Gln Gly Lys           
        275                 280                 285                       

aat gac cca tca tct act ttc tcc aaa gaa aac cta att ttc tca gtg        912
Asn Asp Pro Ser Ser Thr Phe Ser Lys Glu Asn Leu Ile Phe Ser Val           
    290                 295                 300                           

ggt gaa ctc atc att gct gga act gaa act aca acc aat gtg cta cgg        960
Gly Glu Leu Ile Ile Ala Gly Thr Glu Thr Thr Thr Asn Val Leu Arg           
305                 310                 315                 320           

tgg gcg att ctt ttc atg gcc ctt tat cct aat att caa gga caa gtt       1008
Trp Ala Ile Leu Phe Met Ala Leu Tyr Pro Asn Ile Gln Gly Gln Val           
                325                 330                 335               

cag aaa gag att gat tta att atg ggc cct aat ggg aag cct tct tgg       1056
Gln Lys Glu Ile Asp Leu Ile Met Gly Pro Asn Gly Lys Pro Ser Trp           
            340                 345                 350                   

gac gac aaa tgc aaa atg cct tat act gag gca gtt ttg cat gaa gtt       1104
Asp Asp Lys Cys Lys Met Pro Tyr Thr Glu Ala Val Leu His Glu Val           
        355                 360                 365                       

tta aga ttc tgt aat ata gtt cca tta ggg att ttc cat gca acc tct       1152
Leu Arg Phe Cys Asn Ile Val Pro Leu Gly Ile Phe His Ala Thr Ser           
    370                 375                 380                           

gaa gat gca gtt gta cgt ggt tat tcc att cct aaa ggc aca aca gta       1200
Glu Asp Ala Val Val Arg Gly Tyr Ser Ile Pro Lys Gly Thr Thr Val           
385                 390                 395                 400           

att aca aat ctt tat tct gta cac ttt gat gaa aag tac tgg aga gac       1248
Ile Thr Asn Leu Tyr Ser Val His Phe Asp Glu Lys Tyr Trp Arg Asp           
                405                 410                 415               

cca gaa gtg ttc cat cct gag cga ttt ctg gac agc agt gga tat ttt       1296
Pro Glu Val Phe His Pro Glu Arg Phe Leu Asp Ser Ser Gly Tyr Phe           
            420                 425                 430                   

gcc aag aag gaa gct ttg gtt cct ttt tcc cta gga aga aga cat tgt       1344
Ala Lys Lys Glu Ala Leu Val Pro Phe Ser Leu Gly Arg Arg His Cys           
        435                 440                 445                       

ctt gga gaa cac ttg gct cgg atg gaa atg ttc ttg ttt ttt aca gca       1392
Leu Gly Glu His Leu Ala Arg Met Glu Met Phe Leu Phe Phe Thr Ala           
    450                 455                 460                           

ttg ctt cag agg ttt cat ttg cat ttt cca cat gaa cta gtt cca gat       1440
Leu Leu Gln Arg Phe His Leu His Phe Pro His Glu Leu Val Pro Asp           
465                 470                 475                 480           

ctg aag ccc agg tta ggc atg aca ttg cag ccc caa ccc tac ctc atc       1488
Leu Lys Pro Arg Leu Gly Met Thr Leu Gln Pro Gln Pro Tyr Leu Ile           
                485                 490                 495               

tgt gct gaa aga cgc tga aactgcctgg gatgttttcg ggaacaagaa              1536
Cys Ala Glu Arg Arg                                                       
            500                                                           

tgtatatttg ccttatccct gaacttggtt taatcaaatc aatgtgtgta ttagaataaa     1596

agtcacagca tcaaaaagcc aaaaaaaaaa aaaaaaa                              1633


<210>  456
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  456

Met Trp Lys Leu Trp Arg Ala Glu Glu Gly Ala Ala Ala Leu Gly Gly 
1               5                   10                  15      


Ala Leu Phe Leu Leu Leu Phe Ala Leu Gly Val Arg Gln Leu Leu Lys 
            20                  25                  30          


Gln Arg Arg Pro Met Gly Phe Pro Pro Gly Pro Pro Gly Leu Pro Phe 
        35                  40                  45              


Ile Gly Asn Ile Tyr Ser Leu Ala Ala Ser Ser Glu Leu Pro His Val 
    50                  55                  60                  


Tyr Met Arg Lys Gln Ser Gln Val Tyr Gly Glu Ile Phe Ser Leu Asp 
65                  70                  75                  80  


Leu Gly Gly Ile Ser Thr Val Val Leu Asn Gly Tyr Asp Val Val Lys 
                85                  90                  95      


Glu Cys Leu Val His Gln Ser Glu Ile Phe Ala Asp Arg Pro Cys Leu 
            100                 105                 110         


Pro Leu Phe Met Lys Met Thr Lys Met Gly Gly Leu Leu Asn Ser Arg 
        115                 120                 125             


Tyr Gly Arg Gly Trp Val Asp His Arg Arg Leu Ala Val Asn Ser Phe 
    130                 135                 140                 


Arg Tyr Phe Gly Tyr Gly Gln Lys Ser Phe Glu Ser Lys Ile Leu Glu 
145                 150                 155                 160 


Glu Thr Lys Phe Phe Asn Asp Ala Ile Glu Thr Tyr Lys Gly Arg Pro 
                165                 170                 175     


Phe Asp Phe Lys Gln Leu Ile Thr Asn Ala Val Ser Asn Ile Thr Asn 
            180                 185                 190         


Leu Ile Ile Phe Gly Glu Arg Phe Thr Tyr Glu Asp Thr Asp Phe Gln 
        195                 200                 205             


His Met Ile Glu Leu Phe Ser Glu Asn Val Glu Leu Ala Ala Ser Ala 
    210                 215                 220                 


Ser Val Phe Leu Tyr Asn Ala Phe Pro Trp Ile Gly Ile Leu Pro Phe 
225                 230                 235                 240 


Gly Lys His Gln Gln Leu Phe Arg Asn Ala Ala Val Val Tyr Asp Phe 
                245                 250                 255     


Leu Ser Arg Leu Ile Glu Lys Ala Ser Val Asn Arg Lys Pro Gln Leu 
            260                 265                 270         


Pro Gln His Phe Val Asp Ala Tyr Leu Asp Glu Met Asp Gln Gly Lys 
        275                 280                 285             


Asn Asp Pro Ser Ser Thr Phe Ser Lys Glu Asn Leu Ile Phe Ser Val 
    290                 295                 300                 


Gly Glu Leu Ile Ile Ala Gly Thr Glu Thr Thr Thr Asn Val Leu Arg 
305                 310                 315                 320 


Trp Ala Ile Leu Phe Met Ala Leu Tyr Pro Asn Ile Gln Gly Gln Val 
                325                 330                 335     


Gln Lys Glu Ile Asp Leu Ile Met Gly Pro Asn Gly Lys Pro Ser Trp 
            340                 345                 350         


Asp Asp Lys Cys Lys Met Pro Tyr Thr Glu Ala Val Leu His Glu Val 
        355                 360                 365             


Leu Arg Phe Cys Asn Ile Val Pro Leu Gly Ile Phe His Ala Thr Ser 
    370                 375                 380                 


Glu Asp Ala Val Val Arg Gly Tyr Ser Ile Pro Lys Gly Thr Thr Val 
385                 390                 395                 400 


Ile Thr Asn Leu Tyr Ser Val His Phe Asp Glu Lys Tyr Trp Arg Asp 
                405                 410                 415     


Pro Glu Val Phe His Pro Glu Arg Phe Leu Asp Ser Ser Gly Tyr Phe 
            420                 425                 430         


Ala Lys Lys Glu Ala Leu Val Pro Phe Ser Leu Gly Arg Arg His Cys 
        435                 440                 445             


Leu Gly Glu His Leu Ala Arg Met Glu Met Phe Leu Phe Phe Thr Ala 
    450                 455                 460                 


Leu Leu Gln Arg Phe His Leu His Phe Pro His Glu Leu Val Pro Asp 
465                 470                 475                 480 


Leu Lys Pro Arg Leu Gly Met Thr Leu Gln Pro Gln Pro Tyr Leu Ile 
                485                 490                 495     


Cys Ala Glu Arg Arg 
            500     


<210>  457
<211>  2884
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (382)..(1797)

<400>  457
tcgattctca agagggtttc attggtctca acctggcccc ccaggcaacc cacccctgat       60

tggacagtct catcaagaag gttggtcaag agctcaagtg tttctgagaa tctgggtgat      120

ttataagaaa cccttagctg aatgcagggt ggggagaacg aaagacaaaa gcatcttttt      180

tcagaaggga aactgaaaga aagaggggaa gagtattaaa gaccatttct ggctgggcag      240

ggcactctca gcagctcaac tgcccagcgt gaccagtggc cacctctgca gtgtcttcca      300

caacctggtc ttgactcgtc tgctgaacaa atcctctgac ctcaggccgg ctgtgaacgt      360

agttcctgag agatagcaaa c atg ccc aac agt gag ccc gca tct ctg ctg        411
                        Met Pro Asn Ser Glu Pro Ala Ser Leu Leu           
                        1               5                   10            

gag ctg ttc aac agc atc gcc aca caa ggg gag ctc gta agg tcc ctc        459
Glu Leu Phe Asn Ser Ile Ala Thr Gln Gly Glu Leu Val Arg Ser Leu           
                15                  20                  25                

aaa gcg gga aat gcg tca aag gat gaa att gat tct gca gta aag atg        507
Lys Ala Gly Asn Ala Ser Lys Asp Glu Ile Asp Ser Ala Val Lys Met           
            30                  35                  40                    

ttg gtg tca tta aaa atg agc tac aaa gct gcc gcg ggg gag gat tac        555
Leu Val Ser Leu Lys Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr           
        45                  50                  55                        

aag gct gac tgt cct cca ggg aac cca gca cct acc agt aat cat ggc        603
Lys Ala Asp Cys Pro Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly           
    60                  65                  70                            

cca gat gcc aca gaa gct gaa gag gat ttt gtg gac cca tgg aca gta        651
Pro Asp Ala Thr Glu Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val           
75                  80                  85                  90            

cag aca agc agt gca aaa ggc ata gac tac gat aag ctc att gtt cgg        699
Gln Thr Ser Ser Ala Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg           
                95                  100                 105               

ttt gga agt agt aaa att gac aaa gag cta ata aac cga ata gag aga        747
Phe Gly Ser Ser Lys Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg           
            110                 115                 120                   

gcc acc ggc caa aga cca cac cac ttc ctg cgc aga ggc atc ttc ttc        795
Ala Thr Gly Gln Arg Pro His His Phe Leu Arg Arg Gly Ile Phe Phe           
        125                 130                 135                       

tca cac aga gat atg aat cag gtt ctt gat gcc tat gaa aat aag aag        843
Ser His Arg Asp Met Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys           
    140                 145                 150                           

cca ttt tat ctg tac acg ggc cgg ggc ccc tct tct gaa gca atg cat        891
Pro Phe Tyr Leu Tyr Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His           
155                 160                 165                 170           

gta ggt cac ctc att cca ttt att ttc aca aag tgg ctc cag gat gta        939
Val Gly His Leu Ile Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val           
                175                 180                 185               

ttt aac gtg ccc ttg gtc atc cag atg acg gat gac gag aag tat ctg        987
Phe Asn Val Pro Leu Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu           
            190                 195                 200                   

tgg aag gac ctg acc ctg gac cag gcc tat agc tat gct gtg gag aat       1035
Trp Lys Asp Leu Thr Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn           
        205                 210                 215                       

gcc aag gac atc atc gcc tgt ggc ttt gac atc aac aag act ttc ata       1083
Ala Lys Asp Ile Ile Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile           
    220                 225                 230                           

ttc tct gac ctg gac tac atg ggg atg agc tca ggt ttc tac aaa aat       1131
Phe Ser Asp Leu Asp Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn           
235                 240                 245                 250           

gtg gtg aag att caa aag cat gtt acc ttc aac caa gtg aaa ggc att       1179
Val Val Lys Ile Gln Lys His Val Thr Phe Asn Gln Val Lys Gly Ile           
                255                 260                 265               

ttc ggc ttc act gac agc gac tgc att ggg aag atc agt ttt cct gcc       1227
Phe Gly Phe Thr Asp Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala           
            270                 275                 280                   

atc cag gct gct ccc tcc ttc agc aac tca ttc cca cag atc ttc cga       1275
Ile Gln Ala Ala Pro Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg           
        285                 290                 295                       

gac agg acg gat atc cag tgc ctt atc cca tgt gcc att gac cag gat       1323
Asp Arg Thr Asp Ile Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp           
    300                 305                 310                           

cct tac ttt aga atg aca agg gac gtc gcc ccc agg atc ggc tat cct       1371
Pro Tyr Phe Arg Met Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro           
315                 320                 325                 330           

aaa cca gcc ctg ctg cac tcc acc ttc ttc cca gcc ctg cag ggc gcc       1419
Lys Pro Ala Leu Leu His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala           
                335                 340                 345               

cag acc aaa atg agt gcc agc gac ccc aac tcc tcc atc ttc ctc acc       1467
Gln Thr Lys Met Ser Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr           
            350                 355                 360                   

gac acg gcc aag cag atc aaa acc aag gtc aat aag cat gcg ttt tct       1515
Asp Thr Ala Lys Gln Ile Lys Thr Lys Val Asn Lys His Ala Phe Ser           
        365                 370                 375                       

gga ggg aga gac acc atc gag gag cac agg cag ttt ggg ggc aac tgt       1563
Gly Gly Arg Asp Thr Ile Glu Glu His Arg Gln Phe Gly Gly Asn Cys           
    380                 385                 390                           

gat gtg gac gtg tct ttc atg tac ctg acc ttc ttc ctc gag gac gac       1611
Asp Val Asp Val Ser Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp           
395                 400                 405                 410           

gac aag ctc gag cag atc agg aag gat tac acc agc gga gcc atg ctc       1659
Asp Lys Leu Glu Gln Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu           
                415                 420                 425               

acc ggt gag ctc aag aag gca ctc ata gag gtt ctg cag ccc ttg atc       1707
Thr Gly Glu Leu Lys Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile           
            430                 435                 440                   

gca gag cac cag gcc cgg cgc aag gag gtc acg gat gag ata gtg aaa       1755
Ala Glu His Gln Ala Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys           
        445                 450                 455                       

gag ttc atg act ccc cgg aag ctg tcc ttc gac ttt cag tag               1797
Glu Phe Met Thr Pro Arg Lys Leu Ser Phe Asp Phe Gln                       
    460                 465                 470                           

cactcgtttt acatatgctt ataaaagaag tgatgtatca gtaatgtatc aataatccca     1857

gcccagtcaa agcaccgcca cctgtaggct tctgtctcat ggtaattact gggcctggcc     1917

tctgtaagcc tgtgtatgtt atcaatactg tttcttcctg tgagttccat tatttctatc     1977

tcttatgggc aaagcattgt gggtaattgg tgctggctaa cattgcatgg tcggatagag     2037

aagtccagct gtgagtctct ccccaaagca gccccacagt ggagcctttg gctggaagtc     2097

catgggccac cctgttcttg tccatggagg actccgaggg ttccaagtat actcttaaga     2157

cccactctgt ttaaaaatat atattctatg tatgcgtata tggaattgaa atgtcattat     2217

tgtaacctag aaagtgcttt gaaatattga tgtggggagg tttattgagc acaagatgta     2277

tttcagccca tgccccctcc caaaaagaaa ttgataagta aaagcttcgt tatacatttg     2337

actaagaaat cacccagctt taaagctgct tttaacaatg aagattgaac agagttcagc     2397

aattttgatt aaattaagac ttgggggtga aactttccag tttactgaac tccagaccat     2457

gcatgtagtc cactccagaa atcatgctcg cttcccttgg cacaccagtg ttctcctgcc     2517

aaatgaccct agaccctctg tcctgcagag tcagggtggc ttttcccctg actgtgtccg     2577

atgccaagga gtcctggcct ccgcagatgc ttcattttga cccttggctg cagtggaagt     2637

cagcacagag cagtgccctg gctgtgtccc tggacgggtg gacttagcta gggagaaagt     2697

cgaggcagca gccctcgagg ccctcacaga tgtctaggca ggcctcattt catcacgcag     2757

catgtgcagg cctggaagag caaagccaaa tctcagggaa gtccttggtt gatgtatctg     2817

ggtctcctct ggagcactct gccctcctgt cacccagtag agtaaataaa cttccttggc     2877

tcctgct                                                               2884


<210>  458
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  458

Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile 
1               5                   10                  15      


Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser 
            20                  25                  30          


Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met 
        35                  40                  45              


Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro 
    50                  55                  60                  


Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala 
65                  70                  75                  80  


Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys 
                85                  90                  95      


Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile 
            100                 105                 110         


Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro 
        115                 120                 125             


His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn 
    130                 135                 140                 


Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr 
145                 150                 155                 160 


Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro 
                165                 170                 175     


Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val 
            180                 185                 190         


Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu 
        195                 200                 205             


Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala 
    210                 215                 220                 


Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr 
225                 230                 235                 240 


Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys 
                245                 250                 255     


His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser 
            260                 265                 270         


Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser 
        275                 280                 285             


Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln 
    290                 295                 300                 


Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr 
305                 310                 315                 320 


Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His 
                325                 330                 335     


Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala 
            340                 345                 350         


Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile 
        355                 360                 365             


Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile 
    370                 375                 380                 


Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe 
385                 390                 395                 400 


Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile 
                405                 410                 415     


Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys 
            420                 425                 430         


Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
        435                 440                 445             


Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg 
    450                 455                 460                 


Lys Leu Ser Phe Asp Phe Gln 
465                 470     


<210>  459
<211>  4563
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (142)..(3891)

<400>  459
ccctttcttc tcttccaggg ctccgcttta tttgctctca gaagtcggtt tcctttcctt       60

ttcttcagtg aatcggagct cagagcgttg cttcggtttc cctccagaca gttaggaatc      120

tgaaataaac aggaaagcac t atg tct tca atg tgg tct gaa tat aca att        171
                        Met Ser Ser Met Trp Ser Glu Tyr Thr Ile           
                        1               5                   10            

ggt ggg gtg aag att tac ttt cct tat aaa gct tac ccg tca cag ctt        219
Gly Gly Val Lys Ile Tyr Phe Pro Tyr Lys Ala Tyr Pro Ser Gln Leu           
                15                  20                  25                

gct atg atg aat tct att ctc aga gga tta aac agc aag caa cat tgt        267
Ala Met Met Asn Ser Ile Leu Arg Gly Leu Asn Ser Lys Gln His Cys           
            30                  35                  40                    

ttg ttg gag agt ccc aca gga agt gga aaa agc tta gcc tta ctt tgt        315
Leu Leu Glu Ser Pro Thr Gly Ser Gly Lys Ser Leu Ala Leu Leu Cys           
        45                  50                  55                        

tct gct tta gca tgg caa caa tct ctt agt ggg aaa cca gca gat gag        363
Ser Ala Leu Ala Trp Gln Gln Ser Leu Ser Gly Lys Pro Ala Asp Glu           
    60                  65                  70                            

ggc gta agt gaa aaa gct gaa gta caa ttg tca tgt tgt tgt gca tgc        411
Gly Val Ser Glu Lys Ala Glu Val Gln Leu Ser Cys Cys Cys Ala Cys           
75                  80                  85                  90            

cat tca aag gat ttt aca aac aat gac atg aac caa gga act tca cgt        459
His Ser Lys Asp Phe Thr Asn Asn Asp Met Asn Gln Gly Thr Ser Arg           
                95                  100                 105               

cat ttc aac tat cca agc aca cca cct tct gaa aga aat ggc act tca        507
His Phe Asn Tyr Pro Ser Thr Pro Pro Ser Glu Arg Asn Gly Thr Ser           
            110                 115                 120                   

tca act tgt caa gac tcc cct gaa aaa acc act ctg gct gca aag tta        555
Ser Thr Cys Gln Asp Ser Pro Glu Lys Thr Thr Leu Ala Ala Lys Leu           
        125                 130                 135                       

tct gct aag aaa cag gca tcc ata tac aga gat gaa aat gat gat ttt        603
Ser Ala Lys Lys Gln Ala Ser Ile Tyr Arg Asp Glu Asn Asp Asp Phe           
    140                 145                 150                           

caa gta gag aag aaa aga att cga ccc tta gaa act aca cag cag att        651
Gln Val Glu Lys Lys Arg Ile Arg Pro Leu Glu Thr Thr Gln Gln Ile           
155                 160                 165                 170           

aga aaa cgt cat tgc ttt gga aca gaa gta cac aat ttg gat gca aaa        699
Arg Lys Arg His Cys Phe Gly Thr Glu Val His Asn Leu Asp Ala Lys           
                175                 180                 185               

gtt gat tca gga aag act gta aaa ctc aac tct cca ctg gaa aag ata        747
Val Asp Ser Gly Lys Thr Val Lys Leu Asn Ser Pro Leu Glu Lys Ile           
            190                 195                 200                   

aac tcc ttt tcg cca cag aaa ccc cct ggc cac tgt tct agg tgc tgt        795
Asn Ser Phe Ser Pro Gln Lys Pro Pro Gly His Cys Ser Arg Cys Cys           
        205                 210                 215                       

tgt tct act aaa caa gga aac agt caa gag tca tcg aat acc att aag        843
Cys Ser Thr Lys Gln Gly Asn Ser Gln Glu Ser Ser Asn Thr Ile Lys           
    220                 225                 230                           

aag gat cat aca ggg aaa tcc aag ata ccc aaa ata tat ttt ggg aca        891
Lys Asp His Thr Gly Lys Ser Lys Ile Pro Lys Ile Tyr Phe Gly Thr           
235                 240                 245                 250           

cgc aca cac aag cag att gct cag att act aga gag ctc cgg agg acg        939
Arg Thr His Lys Gln Ile Ala Gln Ile Thr Arg Glu Leu Arg Arg Thr           
                255                 260                 265               

gca tat tca ggg gtt cca atg act att ctt tcc agc agg gat cat act        987
Ala Tyr Ser Gly Val Pro Met Thr Ile Leu Ser Ser Arg Asp His Thr           
            270                 275                 280                   

tgt gtc cat cct gag gta gtc ggt aac ttc aac aga aat gag aag tgc       1035
Cys Val His Pro Glu Val Val Gly Asn Phe Asn Arg Asn Glu Lys Cys           
        285                 290                 295                       

atg gaa ttg cta gat ggg aaa aac gga aaa tcc tgc tat ttt tat cat       1083
Met Glu Leu Leu Asp Gly Lys Asn Gly Lys Ser Cys Tyr Phe Tyr His           
    300                 305                 310                           

gga gtt cat aaa att agt gat cag cac aca tta cag act ttc caa ggg       1131
Gly Val His Lys Ile Ser Asp Gln His Thr Leu Gln Thr Phe Gln Gly           
315                 320                 325                 330           

atg tgc aaa gcc tgg gat ata gaa gaa ctt gtc agc ctg ggg aag aaa       1179
Met Cys Lys Ala Trp Asp Ile Glu Glu Leu Val Ser Leu Gly Lys Lys           
                335                 340                 345               

cta aag gcc tgt cca tat tac aca gcc cga gaa cta ata caa gat gct       1227
Leu Lys Ala Cys Pro Tyr Tyr Thr Ala Arg Glu Leu Ile Gln Asp Ala           
            350                 355                 360                   

gac atc ata ttt tgt ccc tac aac tat ctt cta gat gca caa ata agg       1275
Asp Ile Ile Phe Cys Pro Tyr Asn Tyr Leu Leu Asp Ala Gln Ile Arg           
        365                 370                 375                       

gaa agt atg gat tta aat ctg aaa gaa cag gtt gtc att tta gat gaa       1323
Glu Ser Met Asp Leu Asn Leu Lys Glu Gln Val Val Ile Leu Asp Glu           
    380                 385                 390                           

gct cat aac atc gag gac tgt gct cgg gaa tca gca agt tac agt gta       1371
Ala His Asn Ile Glu Asp Cys Ala Arg Glu Ser Ala Ser Tyr Ser Val           
395                 400                 405                 410           

aca gaa gtt cag ctt cgg ttt gct cgg gat gaa cta gat agt atg gtc       1419
Thr Glu Val Gln Leu Arg Phe Ala Arg Asp Glu Leu Asp Ser Met Val           
                415                 420                 425               

aac aat aat ata agg aag aaa gat cat gaa ccc cta cga gct gtg tgc       1467
Asn Asn Asn Ile Arg Lys Lys Asp His Glu Pro Leu Arg Ala Val Cys           
            430                 435                 440                   

tgt agc ctc att aat tgg tta gaa gca aac gct gaa tat ctt gta gaa       1515
Cys Ser Leu Ile Asn Trp Leu Glu Ala Asn Ala Glu Tyr Leu Val Glu           
        445                 450                 455                       

aga gat tat gaa tca gct tgt aaa ata tgg agt gga aat gaa atg ctc       1563
Arg Asp Tyr Glu Ser Ala Cys Lys Ile Trp Ser Gly Asn Glu Met Leu           
    460                 465                 470                           

tta act tta cac aaa atg ggt atc acc act gct act ttt ccc att ttg       1611
Leu Thr Leu His Lys Met Gly Ile Thr Thr Ala Thr Phe Pro Ile Leu           
475                 480                 485                 490           

cag gga cat ttt tct gct gtt ctt caa aaa gag gaa aaa atc tca cca       1659
Gln Gly His Phe Ser Ala Val Leu Gln Lys Glu Glu Lys Ile Ser Pro           
                495                 500                 505               

att tat ggt aaa gag gag gca aga gaa gta cct gtt att agt gca tca       1707
Ile Tyr Gly Lys Glu Glu Ala Arg Glu Val Pro Val Ile Ser Ala Ser           
            510                 515                 520                   

act caa ata atg ctt aaa gga ctt ttt atg gta ctt gac tat ctt ttt       1755
Thr Gln Ile Met Leu Lys Gly Leu Phe Met Val Leu Asp Tyr Leu Phe           
        525                 530                 535                       

agg caa aat agc aga ttt gca gat gat tat aaa att gcg att caa cag       1803
Arg Gln Asn Ser Arg Phe Ala Asp Asp Tyr Lys Ile Ala Ile Gln Gln           
    540                 545                 550                           

act tac tcc tgg aca aat cag att gat att tca gac aaa aat ggg ttg       1851
Thr Tyr Ser Trp Thr Asn Gln Ile Asp Ile Ser Asp Lys Asn Gly Leu           
555                 560                 565                 570           

ttg gtt cta cca aaa aat aag aaa cgt tca cga cag aaa act gca gtt       1899
Leu Val Leu Pro Lys Asn Lys Lys Arg Ser Arg Gln Lys Thr Ala Val           
                575                 580                 585               

cat gtg cta aac ttt tgg tgc tta aat cca gct gtg gcc ttt tca gat       1947
His Val Leu Asn Phe Trp Cys Leu Asn Pro Ala Val Ala Phe Ser Asp           
            590                 595                 600                   

att aat ggc aaa gtt cag acc att gtt ttg aca tct ggt aca tta tca       1995
Ile Asn Gly Lys Val Gln Thr Ile Val Leu Thr Ser Gly Thr Leu Ser           
        605                 610                 615                       

cca atg aaa tcc ttt tcg tca gaa ctt ggt gtt aca ttt act atc cag       2043
Pro Met Lys Ser Phe Ser Ser Glu Leu Gly Val Thr Phe Thr Ile Gln           
    620                 625                 630                           

ctg gag gct aat cat atc att aaa aat tca cag gtt tgg gtt ggt acc       2091
Leu Glu Ala Asn His Ile Ile Lys Asn Ser Gln Val Trp Val Gly Thr           
635                 640                 645                 650           

att ggg tca ggc ccc aag ggt cgg aat ctc tgt gct acc ttc cag aat       2139
Ile Gly Ser Gly Pro Lys Gly Arg Asn Leu Cys Ala Thr Phe Gln Asn           
                655                 660                 665               

act gaa aca ttt gag ttc caa gat gaa gtg gga gca ctt ttg tta tct       2187
Thr Glu Thr Phe Glu Phe Gln Asp Glu Val Gly Ala Leu Leu Leu Ser           
            670                 675                 680                   

gtg tgc cag act gtg agc caa gga att ttg tgt ttc ttg cca tct tac       2235
Val Cys Gln Thr Val Ser Gln Gly Ile Leu Cys Phe Leu Pro Ser Tyr           
        685                 690                 695                       

aag tta tta gaa aaa tta aaa gaa cgt tgg ctc tct act ggt tta tgg       2283
Lys Leu Leu Glu Lys Leu Lys Glu Arg Trp Leu Ser Thr Gly Leu Trp           
    700                 705                 710                           

cat aat ctg gag ttg gtg aag aca gtc att gta gaa cca cag gga gga       2331
His Asn Leu Glu Leu Val Lys Thr Val Ile Val Glu Pro Gln Gly Gly           
715                 720                 725                 730           

gaa aaa aca aat ttt gat gaa tta ctg cag gtg tac tat gac gca atc       2379
Glu Lys Thr Asn Phe Asp Glu Leu Leu Gln Val Tyr Tyr Asp Ala Ile           
                735                 740                 745               

aaa tac aaa gga gag aaa gat gga gct ctc ctg gta gca gtt tgt cgt       2427
Lys Tyr Lys Gly Glu Lys Asp Gly Ala Leu Leu Val Ala Val Cys Arg           
            750                 755                 760                   

ggt aaa gtg agt gag ggt ctg gat ttc tca gat gac aat gcc cgt gct       2475
Gly Lys Val Ser Glu Gly Leu Asp Phe Ser Asp Asp Asn Ala Arg Ala           
        765                 770                 775                       

gtc ata aca ata gga att cct ttt cca aat gtg aaa gat cta cag gtt       2523
Val Ile Thr Ile Gly Ile Pro Phe Pro Asn Val Lys Asp Leu Gln Val           
    780                 785                 790                           

gaa cta aaa cga caa tac aat gac cac cat tca aaa ttg aga ggt ctt       2571
Glu Leu Lys Arg Gln Tyr Asn Asp His His Ser Lys Leu Arg Gly Leu           
795                 800                 805                 810           

cta cct ggc cgt cag tgg tat gaa att caa gca tac agg gcc tta aac       2619
Leu Pro Gly Arg Gln Trp Tyr Glu Ile Gln Ala Tyr Arg Ala Leu Asn           
                815                 820                 825               

cag gcc ctt ggt aga tgt att aga cac aga aat gat tgg gga gct ctt       2667
Gln Ala Leu Gly Arg Cys Ile Arg His Arg Asn Asp Trp Gly Ala Leu           
            830                 835                 840                   

att cta gtg gat gat cgc ttt agg aat aac cca agt cgc tat ata tct       2715
Ile Leu Val Asp Asp Arg Phe Arg Asn Asn Pro Ser Arg Tyr Ile Ser           
        845                 850                 855                       

gga ctt tct aaa tgg gta cgg cag cag att cag cac cat tca acc ttt       2763
Gly Leu Ser Lys Trp Val Arg Gln Gln Ile Gln His His Ser Thr Phe           
    860                 865                 870                           

gaa agt gca ctg gag tcc ttg gct gaa ttt tcc aaa aag cat caa aaa       2811
Glu Ser Ala Leu Glu Ser Leu Ala Glu Phe Ser Lys Lys His Gln Lys           
875                 880                 885                 890           

gtt ctt aat gta tcc ata aag gac aga acc aat ata cag gac aat gag       2859
Val Leu Asn Val Ser Ile Lys Asp Arg Thr Asn Ile Gln Asp Asn Glu           
                895                 900                 905               

tct aca ctt gaa gtg acc tct tta aag tac agt acc cca cct tat tta       2907
Ser Thr Leu Glu Val Thr Ser Leu Lys Tyr Ser Thr Pro Pro Tyr Leu           
            910                 915                 920                   

ctg gaa gca gca agt cat cta tca cca gaa aat ttt gtg gaa gat gaa       2955
Leu Glu Ala Ala Ser His Leu Ser Pro Glu Asn Phe Val Glu Asp Glu           
        925                 930                 935                       

gca aag ata tgt gtc cag gaa cta cag tgt cct aaa att att acc aaa       3003
Ala Lys Ile Cys Val Gln Glu Leu Gln Cys Pro Lys Ile Ile Thr Lys           
    940                 945                 950                           

aat tca cct cta cca agt agc att atc tcc aga aag gag aaa aat gat       3051
Asn Ser Pro Leu Pro Ser Ser Ile Ile Ser Arg Lys Glu Lys Asn Asp           
955                 960                 965                 970           

cca gta ttc ctg gaa gaa gca ggg aaa gca gaa aaa att gtg att tcc       3099
Pro Val Phe Leu Glu Glu Ala Gly Lys Ala Glu Lys Ile Val Ile Ser           
                975                 980                 985               

aga tcc aca agc cca act ttc aac aaa caa aca aag aga gtt  agc tgg      3147
Arg Ser Thr Ser Pro Thr Phe Asn Lys Gln Thr Lys Arg Val  Ser Trp          
            990                 995                 1000                  

tca agc ttt  aat tct ttg gga cag  tat ttt act ggt aaa  ata ccg        3192
Ser Ser Phe  Asn Ser Leu Gly Gln  Tyr Phe Thr Gly Lys  Ile Pro            
        1005                 1010                 1015                    

aag gca aca  cct gag ctc ggg tca  tca gag aat agt gcc  tct agt        3237
Lys Ala Thr  Pro Glu Leu Gly Ser  Ser Glu Asn Ser Ala  Ser Ser            
        1020                 1025                 1030                    

cct ccc cgt  ttc aaa aca gag aag  atg gaa agt aaa act  gtt ttg        3282
Pro Pro Arg  Phe Lys Thr Glu Lys  Met Glu Ser Lys Thr  Val Leu            
        1035                 1040                 1045                    

ccc ttc act  gat aaa tgt gaa tcc  tca aat ctg aca gta  aac aca        3327
Pro Phe Thr  Asp Lys Cys Glu Ser  Ser Asn Leu Thr Val  Asn Thr            
        1050                 1055                 1060                    

tcg ttt gga  tca tgc cct caa tca  gaa acc att att tca  tca tta        3372
Ser Phe Gly  Ser Cys Pro Gln Ser  Glu Thr Ile Ile Ser  Ser Leu            
        1065                 1070                 1075                    

aag att gat  gcc acc ctt act aga  aaa aat cat tct gaa  cat ccg        3417
Lys Ile Asp  Ala Thr Leu Thr Arg  Lys Asn His Ser Glu  His Pro            
        1080                 1085                 1090                    

ctc tgt tct  gaa gaa gcc ctg gat  cca gac att gaa ttg  tct cta        3462
Leu Cys Ser  Glu Glu Ala Leu Asp  Pro Asp Ile Glu Leu  Ser Leu            
        1095                 1100                 1105                    

gta agt gaa  gaa gat aaa cag tcc  act tca aat aga gat  ttt gaa        3507
Val Ser Glu  Glu Asp Lys Gln Ser  Thr Ser Asn Arg Asp  Phe Glu            
        1110                 1115                 1120                    

aca gaa gca  gaa gat gaa tct atc  tat ttt aca cct gaa  ctt tac        3552
Thr Glu Ala  Glu Asp Glu Ser Ile  Tyr Phe Thr Pro Glu  Leu Tyr            
        1125                 1130                 1135                    

gat cct gaa  gat aca gat gaa gaa  aaa aat gac cta gct  gaa act        3597
Asp Pro Glu  Asp Thr Asp Glu Glu  Lys Asn Asp Leu Ala  Glu Thr            
        1140                 1145                 1150                    

gat aga gga  aat aga ttg gct aac  aat tca gat tgc att  tta gct        3642
Asp Arg Gly  Asn Arg Leu Ala Asn  Asn Ser Asp Cys Ile  Leu Ala            
        1155                 1160                 1165                    

aaa gac ctt  ttt gaa att aga act  ata aaa gaa gta gat  tca gcc        3687
Lys Asp Leu  Phe Glu Ile Arg Thr  Ile Lys Glu Val Asp  Ser Ala            
        1170                 1175                 1180                    

aga gaa gtg  aaa gct gag gat tgc  ata gat aca aag ttg  aat gga        3732
Arg Glu Val  Lys Ala Glu Asp Cys  Ile Asp Thr Lys Leu  Asn Gly            
        1185                 1190                 1195                    

att ctg cat  att gaa gaa agt aaa  att gat gac att gat  ggt aat        3777
Ile Leu His  Ile Glu Glu Ser Lys  Ile Asp Asp Ile Asp  Gly Asn            
        1200                 1205                 1210                    

gta aaa aca  act tgg ata aat gaa  ctg gaa ctg gga aaa  act cat        3822
Val Lys Thr  Thr Trp Ile Asn Glu  Leu Glu Leu Gly Lys  Thr His            
        1215                 1220                 1225                    

gaa ata gaa  ata aag aac ttt aaa  cca tct cct tcc aaa  aat aaa        3867
Glu Ile Glu  Ile Lys Asn Phe Lys  Pro Ser Pro Ser Lys  Asn Lys            
        1230                 1235                 1240                    

ggc atg ttt  cct ggt ttt aag taa taatacttaa ctctcaagct aagtaaaaat     3921
Gly Met Phe  Pro Gly Phe Lys                                              
        1245                                                              

atgtcatcat gcttatgtta aactctgttg taagtaataa tttgtaaatt gaataagtgg     3981

catacttttt aaaaaactat tttatgttca gaaatgtaaa tgttattatt cttgagtttt     4041

tgggtttctt tttttgagac agagtcttgg tctgttgccc aggctggaat gcagtggtgt     4101

gctctgggct cactgcaacc ttcacctcca ggttcaagtg attctcctgc ctcagccttc     4161

tgagtagctg ggactacagg tgtgcaccac catgcccagc tagtttttgt atttttagta     4221

gagatggggt ttcaccatgt tggccaggct ggtctcgaac tcctggcctc gtgatctgcc     4281

cttctctgcc tccctaagtt gctgggatta caggtgtgag ccacagtgcc tggcccattc     4341

ttgagttttg ataaagtaat tcatacaaag tattgtcctc aaataagtct tccttagcta     4401

aatgcaattt aaaattattc aaagatccta gggcacttct agtttcacgt aaatattcat     4461

attaggtggt tctcttcatc catttgtttt cacactgata cataaaaatt aacagcagtc     4521

taatctagtg acacctcagt catatttcgc tatagatttt ac                        4563


<210>  460
<211>  1249
<212>  PRT
<213>  Homo sapiens

<400>  460

Met Ser Ser Met Trp Ser Glu Tyr Thr Ile Gly Gly Val Lys Ile Tyr 
1               5                   10                  15      


Phe Pro Tyr Lys Ala Tyr Pro Ser Gln Leu Ala Met Met Asn Ser Ile 
            20                  25                  30          


Leu Arg Gly Leu Asn Ser Lys Gln His Cys Leu Leu Glu Ser Pro Thr 
        35                  40                  45              


Gly Ser Gly Lys Ser Leu Ala Leu Leu Cys Ser Ala Leu Ala Trp Gln 
    50                  55                  60                  


Gln Ser Leu Ser Gly Lys Pro Ala Asp Glu Gly Val Ser Glu Lys Ala 
65                  70                  75                  80  


Glu Val Gln Leu Ser Cys Cys Cys Ala Cys His Ser Lys Asp Phe Thr 
                85                  90                  95      


Asn Asn Asp Met Asn Gln Gly Thr Ser Arg His Phe Asn Tyr Pro Ser 
            100                 105                 110         


Thr Pro Pro Ser Glu Arg Asn Gly Thr Ser Ser Thr Cys Gln Asp Ser 
        115                 120                 125             


Pro Glu Lys Thr Thr Leu Ala Ala Lys Leu Ser Ala Lys Lys Gln Ala 
    130                 135                 140                 


Ser Ile Tyr Arg Asp Glu Asn Asp Asp Phe Gln Val Glu Lys Lys Arg 
145                 150                 155                 160 


Ile Arg Pro Leu Glu Thr Thr Gln Gln Ile Arg Lys Arg His Cys Phe 
                165                 170                 175     


Gly Thr Glu Val His Asn Leu Asp Ala Lys Val Asp Ser Gly Lys Thr 
            180                 185                 190         


Val Lys Leu Asn Ser Pro Leu Glu Lys Ile Asn Ser Phe Ser Pro Gln 
        195                 200                 205             


Lys Pro Pro Gly His Cys Ser Arg Cys Cys Cys Ser Thr Lys Gln Gly 
    210                 215                 220                 


Asn Ser Gln Glu Ser Ser Asn Thr Ile Lys Lys Asp His Thr Gly Lys 
225                 230                 235                 240 


Ser Lys Ile Pro Lys Ile Tyr Phe Gly Thr Arg Thr His Lys Gln Ile 
                245                 250                 255     


Ala Gln Ile Thr Arg Glu Leu Arg Arg Thr Ala Tyr Ser Gly Val Pro 
            260                 265                 270         


Met Thr Ile Leu Ser Ser Arg Asp His Thr Cys Val His Pro Glu Val 
        275                 280                 285             


Val Gly Asn Phe Asn Arg Asn Glu Lys Cys Met Glu Leu Leu Asp Gly 
    290                 295                 300                 


Lys Asn Gly Lys Ser Cys Tyr Phe Tyr His Gly Val His Lys Ile Ser 
305                 310                 315                 320 


Asp Gln His Thr Leu Gln Thr Phe Gln Gly Met Cys Lys Ala Trp Asp 
                325                 330                 335     


Ile Glu Glu Leu Val Ser Leu Gly Lys Lys Leu Lys Ala Cys Pro Tyr 
            340                 345                 350         


Tyr Thr Ala Arg Glu Leu Ile Gln Asp Ala Asp Ile Ile Phe Cys Pro 
        355                 360                 365             


Tyr Asn Tyr Leu Leu Asp Ala Gln Ile Arg Glu Ser Met Asp Leu Asn 
    370                 375                 380                 


Leu Lys Glu Gln Val Val Ile Leu Asp Glu Ala His Asn Ile Glu Asp 
385                 390                 395                 400 


Cys Ala Arg Glu Ser Ala Ser Tyr Ser Val Thr Glu Val Gln Leu Arg 
                405                 410                 415     


Phe Ala Arg Asp Glu Leu Asp Ser Met Val Asn Asn Asn Ile Arg Lys 
            420                 425                 430         


Lys Asp His Glu Pro Leu Arg Ala Val Cys Cys Ser Leu Ile Asn Trp 
        435                 440                 445             


Leu Glu Ala Asn Ala Glu Tyr Leu Val Glu Arg Asp Tyr Glu Ser Ala 
    450                 455                 460                 


Cys Lys Ile Trp Ser Gly Asn Glu Met Leu Leu Thr Leu His Lys Met 
465                 470                 475                 480 


Gly Ile Thr Thr Ala Thr Phe Pro Ile Leu Gln Gly His Phe Ser Ala 
                485                 490                 495     


Val Leu Gln Lys Glu Glu Lys Ile Ser Pro Ile Tyr Gly Lys Glu Glu 
            500                 505                 510         


Ala Arg Glu Val Pro Val Ile Ser Ala Ser Thr Gln Ile Met Leu Lys 
        515                 520                 525             


Gly Leu Phe Met Val Leu Asp Tyr Leu Phe Arg Gln Asn Ser Arg Phe 
    530                 535                 540                 


Ala Asp Asp Tyr Lys Ile Ala Ile Gln Gln Thr Tyr Ser Trp Thr Asn 
545                 550                 555                 560 


Gln Ile Asp Ile Ser Asp Lys Asn Gly Leu Leu Val Leu Pro Lys Asn 
                565                 570                 575     


Lys Lys Arg Ser Arg Gln Lys Thr Ala Val His Val Leu Asn Phe Trp 
            580                 585                 590         


Cys Leu Asn Pro Ala Val Ala Phe Ser Asp Ile Asn Gly Lys Val Gln 
        595                 600                 605             


Thr Ile Val Leu Thr Ser Gly Thr Leu Ser Pro Met Lys Ser Phe Ser 
    610                 615                 620                 


Ser Glu Leu Gly Val Thr Phe Thr Ile Gln Leu Glu Ala Asn His Ile 
625                 630                 635                 640 


Ile Lys Asn Ser Gln Val Trp Val Gly Thr Ile Gly Ser Gly Pro Lys 
                645                 650                 655     


Gly Arg Asn Leu Cys Ala Thr Phe Gln Asn Thr Glu Thr Phe Glu Phe 
            660                 665                 670         


Gln Asp Glu Val Gly Ala Leu Leu Leu Ser Val Cys Gln Thr Val Ser 
        675                 680                 685             


Gln Gly Ile Leu Cys Phe Leu Pro Ser Tyr Lys Leu Leu Glu Lys Leu 
    690                 695                 700                 


Lys Glu Arg Trp Leu Ser Thr Gly Leu Trp His Asn Leu Glu Leu Val 
705                 710                 715                 720 


Lys Thr Val Ile Val Glu Pro Gln Gly Gly Glu Lys Thr Asn Phe Asp 
                725                 730                 735     


Glu Leu Leu Gln Val Tyr Tyr Asp Ala Ile Lys Tyr Lys Gly Glu Lys 
            740                 745                 750         


Asp Gly Ala Leu Leu Val Ala Val Cys Arg Gly Lys Val Ser Glu Gly 
        755                 760                 765             


Leu Asp Phe Ser Asp Asp Asn Ala Arg Ala Val Ile Thr Ile Gly Ile 
    770                 775                 780                 


Pro Phe Pro Asn Val Lys Asp Leu Gln Val Glu Leu Lys Arg Gln Tyr 
785                 790                 795                 800 


Asn Asp His His Ser Lys Leu Arg Gly Leu Leu Pro Gly Arg Gln Trp 
                805                 810                 815     


Tyr Glu Ile Gln Ala Tyr Arg Ala Leu Asn Gln Ala Leu Gly Arg Cys 
            820                 825                 830         


Ile Arg His Arg Asn Asp Trp Gly Ala Leu Ile Leu Val Asp Asp Arg 
        835                 840                 845             


Phe Arg Asn Asn Pro Ser Arg Tyr Ile Ser Gly Leu Ser Lys Trp Val 
    850                 855                 860                 


Arg Gln Gln Ile Gln His His Ser Thr Phe Glu Ser Ala Leu Glu Ser 
865                 870                 875                 880 


Leu Ala Glu Phe Ser Lys Lys His Gln Lys Val Leu Asn Val Ser Ile 
                885                 890                 895     


Lys Asp Arg Thr Asn Ile Gln Asp Asn Glu Ser Thr Leu Glu Val Thr 
            900                 905                 910         


Ser Leu Lys Tyr Ser Thr Pro Pro Tyr Leu Leu Glu Ala Ala Ser His 
        915                 920                 925             


Leu Ser Pro Glu Asn Phe Val Glu Asp Glu Ala Lys Ile Cys Val Gln 
    930                 935                 940                 


Glu Leu Gln Cys Pro Lys Ile Ile Thr Lys Asn Ser Pro Leu Pro Ser 
945                 950                 955                 960 


Ser Ile Ile Ser Arg Lys Glu Lys Asn Asp Pro Val Phe Leu Glu Glu 
                965                 970                 975     


Ala Gly Lys Ala Glu Lys Ile Val Ile Ser Arg Ser Thr Ser Pro Thr 
            980                 985                 990         


Phe Asn Lys Gln Thr Lys Arg Val  Ser Trp Ser Ser Phe  Asn Ser Leu 
        995                 1000                 1005             


Gly Gln  Tyr Phe Thr Gly Lys  Ile Pro Lys Ala Thr  Pro Glu Leu 
    1010                 1015                 1020             


Gly Ser  Ser Glu Asn Ser Ala  Ser Ser Pro Pro Arg  Phe Lys Thr 
    1025                 1030                 1035             


Glu Lys  Met Glu Ser Lys Thr  Val Leu Pro Phe Thr  Asp Lys Cys 
    1040                 1045                 1050             


Glu Ser  Ser Asn Leu Thr Val  Asn Thr Ser Phe Gly  Ser Cys Pro 
    1055                 1060                 1065             


Gln Ser  Glu Thr Ile Ile Ser  Ser Leu Lys Ile Asp  Ala Thr Leu 
    1070                 1075                 1080             


Thr Arg  Lys Asn His Ser Glu  His Pro Leu Cys Ser  Glu Glu Ala 
    1085                 1090                 1095             


Leu Asp  Pro Asp Ile Glu Leu  Ser Leu Val Ser Glu  Glu Asp Lys 
    1100                 1105                 1110             


Gln Ser  Thr Ser Asn Arg Asp  Phe Glu Thr Glu Ala  Glu Asp Glu 
    1115                 1120                 1125             


Ser Ile  Tyr Phe Thr Pro Glu  Leu Tyr Asp Pro Glu  Asp Thr Asp 
    1130                 1135                 1140             


Glu Glu  Lys Asn Asp Leu Ala  Glu Thr Asp Arg Gly  Asn Arg Leu 
    1145                 1150                 1155             


Ala Asn  Asn Ser Asp Cys Ile  Leu Ala Lys Asp Leu  Phe Glu Ile 
    1160                 1165                 1170             


Arg Thr  Ile Lys Glu Val Asp  Ser Ala Arg Glu Val  Lys Ala Glu 
    1175                 1180                 1185             


Asp Cys  Ile Asp Thr Lys Leu  Asn Gly Ile Leu His  Ile Glu Glu 
    1190                 1195                 1200             


Ser Lys  Ile Asp Asp Ile Asp  Gly Asn Val Lys Thr  Thr Trp Ile 
    1205                 1210                 1215             


Asn Glu  Leu Glu Leu Gly Lys  Thr His Glu Ile Glu  Ile Lys Asn 
    1220                 1225                 1230             


Phe Lys  Pro Ser Pro Ser Lys  Asn Lys Gly Met Phe  Pro Gly Phe 
    1235                 1240                 1245             


Lys 
    


<210>  461
<211>  796
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (9)..(746)

<400>  461
cgcagatc atg ggt ggc ggg tat gat ctc aac ctc ttc gcc agc cct cct        50
         Met Gly Gly Gly Tyr Asp Leu Asn Leu Phe Ala Ser Pro Pro          
         1               5                   10                           

gac agc aac ttc gtg tgc tcc gtc tgc cat ggg gtt ctc aag agg cca         98
Asp Ser Asn Phe Val Cys Ser Val Cys His Gly Val Leu Lys Arg Pro           
15                  20                  25                  30            

gca agg ttg cca tgc agc cac atc ttc tgc aaa aag tgc atc ctc cgg        146
Ala Arg Leu Pro Cys Ser His Ile Phe Cys Lys Lys Cys Ile Leu Arg           
                35                  40                  45                

tgg cta gcc aga caa aag acc tgt ccg tgc tgt agg aaa gag gtg aaa        194
Trp Leu Ala Arg Gln Lys Thr Cys Pro Cys Cys Arg Lys Glu Val Lys           
            50                  55                  60                    

agg aaa aag gtt gtc cac atg aat aaa ctc cgg aaa acc att ggc cgc        242
Arg Lys Lys Val Val His Met Asn Lys Leu Arg Lys Thr Ile Gly Arg           
        65                  70                  75                        

ctg gaa gtc aag tgc aag aac gcc gac gct ggc tgc ata gtg aca tgc        290
Leu Glu Val Lys Cys Lys Asn Ala Asp Ala Gly Cys Ile Val Thr Cys           
    80                  85                  90                            

ccc ctg gcc cat cgc aag ggg cac cag gac tca tgc ccc ttt gag cta        338
Pro Leu Ala His Arg Lys Gly His Gln Asp Ser Cys Pro Phe Glu Leu           
95                  100                 105                 110           

acg gcc tgc ccc aac gag ggc tgc acc tcg cag gtg ccg cgt ggg acc        386
Thr Ala Cys Pro Asn Glu Gly Cys Thr Ser Gln Val Pro Arg Gly Thr           
                115                 120                 125               

ctg gca gag cac cgg cag cat tgc cag caa ggg tcc cag cag cgc tgc        434
Leu Ala Glu His Arg Gln His Cys Gln Gln Gly Ser Gln Gln Arg Cys           
            130                 135                 140                   

ccc ctg ggc tgc ggg gcc acc ctg gac ccg gcc gag cgt gct cgc cac        482
Pro Leu Gly Cys Gly Ala Thr Leu Asp Pro Ala Glu Arg Ala Arg His           
        145                 150                 155                       

aac tgc tac cgg gag ctg cac aac gcc tgg agc gtg cgc cag gag cgc        530
Asn Cys Tyr Arg Glu Leu His Asn Ala Trp Ser Val Arg Gln Glu Arg           
    160                 165                 170                           

cgt cgg ccc ctg ctg ctg tcc ctc ctg cgg cgt gtg cgc tgg ctg gac        578
Arg Arg Pro Leu Leu Leu Ser Leu Leu Arg Arg Val Arg Trp Leu Asp           
175                 180                 185                 190           

caa gcc acc agt gtc gtt cgt aga gag ctg gcg gag ctc agc aac ttc        626
Gln Ala Thr Ser Val Val Arg Arg Glu Leu Ala Glu Leu Ser Asn Phe           
                195                 200                 205               

ctg gag gaa gac acc gct ctg ctg gag ggt gcc cca cag gag gag gcc        674
Leu Glu Glu Asp Thr Ala Leu Leu Glu Gly Ala Pro Gln Glu Glu Ala           
            210                 215                 220                   

gag gct gcc cca gaa ggc aac gtt ggg gct gag gtg gtg ggg gag ccc        722
Glu Ala Ala Pro Glu Gly Asn Val Gly Ala Glu Val Val Gly Glu Pro           
        225                 230                 235                       

agg gcc aac ata cct tgt aaa tag gtaaataaaa gcagaccccc ggcctgcctg       776
Arg Ala Asn Ile Pro Cys Lys                                               
    240                 245                                               

cctctgtgcc tgcggccctc                                                  796


<210>  462
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  462

Met Gly Gly Gly Tyr Asp Leu Asn Leu Phe Ala Ser Pro Pro Asp Ser 
1               5                   10                  15      


Asn Phe Val Cys Ser Val Cys His Gly Val Leu Lys Arg Pro Ala Arg 
            20                  25                  30          


Leu Pro Cys Ser His Ile Phe Cys Lys Lys Cys Ile Leu Arg Trp Leu 
        35                  40                  45              


Ala Arg Gln Lys Thr Cys Pro Cys Cys Arg Lys Glu Val Lys Arg Lys 
    50                  55                  60                  


Lys Val Val His Met Asn Lys Leu Arg Lys Thr Ile Gly Arg Leu Glu 
65                  70                  75                  80  


Val Lys Cys Lys Asn Ala Asp Ala Gly Cys Ile Val Thr Cys Pro Leu 
                85                  90                  95      


Ala His Arg Lys Gly His Gln Asp Ser Cys Pro Phe Glu Leu Thr Ala 
            100                 105                 110         


Cys Pro Asn Glu Gly Cys Thr Ser Gln Val Pro Arg Gly Thr Leu Ala 
        115                 120                 125             


Glu His Arg Gln His Cys Gln Gln Gly Ser Gln Gln Arg Cys Pro Leu 
    130                 135                 140                 


Gly Cys Gly Ala Thr Leu Asp Pro Ala Glu Arg Ala Arg His Asn Cys 
145                 150                 155                 160 


Tyr Arg Glu Leu His Asn Ala Trp Ser Val Arg Gln Glu Arg Arg Arg 
                165                 170                 175     


Pro Leu Leu Leu Ser Leu Leu Arg Arg Val Arg Trp Leu Asp Gln Ala 
            180                 185                 190         


Thr Ser Val Val Arg Arg Glu Leu Ala Glu Leu Ser Asn Phe Leu Glu 
        195                 200                 205             


Glu Asp Thr Ala Leu Leu Glu Gly Ala Pro Gln Glu Glu Ala Glu Ala 
    210                 215                 220                 


Ala Pro Glu Gly Asn Val Gly Ala Glu Val Val Gly Glu Pro Arg Ala 
225                 230                 235                 240 


Asn Ile Pro Cys Lys 
                245 


<210>  463
<211>  2603
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (700)..(1563)

<400>  463
attaatccct gagacaaagg tactgaaggc aagtggctga agaacaggct tgattggaca       60

gatgacttgg agatgttcac tggacaggga cagccttgtg aagatctttg tgaatacccg      120

acctcgcaag ctccagagac tacaataatt cacttgccct aggttccaaa gccagcaagt      180

ggaaaacgga gactggaatt ccgcccacag gactccaaag cctgtgcagc aacaccccac      240

tcccccggca ggatcaccag caggacgcgc gggagccagg aagtaagatc cgtacctcca      300

aggctcccat gggcccaagc ctccgcatca acagactggg agggattacg tggggtccca      360

gggccggctc tgaggcggga aaactttctg gaggcggcgg cctcaggccg gagcgggcgc      420

acaccgactg gaggggtcgg attcagggat gtgggtggac cgcatttccc catcttcccc      480

gccgcgcact tcctctggtg caatctccac accccgcgcc ggcccgcctg caacgcgccc      540

tggcactcac cggtgggcga aatttccccg cctccacgtg agagccagct ccgccgtgac      600

ccggaagtcc acttcgagtc gccggcccac cctctcgggt tccggcttct tccgggtcgc      660

ggccttccgg cgaacgcggt taccgtggaa accgcggcc atg gcg gca ccg cgg         714
                                           Met Ala Ala Pro Arg            
                                           1               5              

caa atc ccc agc cac ata gtg cgc ctc aag ccc agc tgc tct aca gac        762
Gln Ile Pro Ser His Ile Val Arg Leu Lys Pro Ser Cys Ser Thr Asp           
                10                  15                  20                

tcg tcg ttc acc cgg acg ccg gtg ccc acc gtg tct ctc gcg tcc cgc        810
Ser Ser Phe Thr Arg Thr Pro Val Pro Thr Val Ser Leu Ala Ser Arg           
            25                  30                  35                    

gag ctg cct gtc tcg tcg tgg cag gtc acc gag ccg tca agc aag aat        858
Glu Leu Pro Val Ser Ser Trp Gln Val Thr Glu Pro Ser Ser Lys Asn           
        40                  45                  50                        

ctg tgg gag cag atc tgc aag gag tat gaa gct gag cag cct ccc ttt        906
Leu Trp Glu Gln Ile Cys Lys Glu Tyr Glu Ala Glu Gln Pro Pro Phe           
    55                  60                  65                            

cca gaa gga tat aaa gtc aaa cag gag cct gtg att acg gtt gcg cca        954
Pro Glu Gly Tyr Lys Val Lys Gln Glu Pro Val Ile Thr Val Ala Pro           
70                  75                  80                  85            

gta gag gaa atg ctt ttt cat ggc ttc agt gca gag cac tat ttt ccg       1002
Val Glu Glu Met Leu Phe His Gly Phe Ser Ala Glu His Tyr Phe Pro           
                90                  95                  100               

gtt tcc cat ttc acc atg atc tca cgt aca ccc tgt cct caa gat aaa       1050
Val Ser His Phe Thr Met Ile Ser Arg Thr Pro Cys Pro Gln Asp Lys           
            105                 110                 115                   

tcg gaa aca atc aac cca aaa aca tgt tct ccc aaa gaa tat ttg gaa       1098
Ser Glu Thr Ile Asn Pro Lys Thr Cys Ser Pro Lys Glu Tyr Leu Glu           
        120                 125                 130                       

act ttc atc ttt cct gtt ctg ctt ccc gga atg gct agc ctg ctt cac       1146
Thr Phe Ile Phe Pro Val Leu Leu Pro Gly Met Ala Ser Leu Leu His           
    135                 140                 145                           

caa gcg aag aaa gaa aaa tgt ttt gag agg aaa aga acc aaa ttc att       1194
Gln Ala Lys Lys Glu Lys Cys Phe Glu Arg Lys Arg Thr Lys Phe Ile           
150                 155                 160                 165           

gcc tgt gat ttt ctg act gag tgg tta tac aac caa aat cca aag agg       1242
Ala Cys Asp Phe Leu Thr Glu Trp Leu Tyr Asn Gln Asn Pro Lys Arg           
                170                 175                 180               

gca ggg gag cca ttc aca gaa ttt ttc tcc att cca ttt gtg gag gag       1290
Ala Gly Glu Pro Phe Thr Glu Phe Phe Ser Ile Pro Phe Val Glu Glu           
            185                 190                 195                   

cgg cta aag caa cac cca cgg ccg cca atc cca ctc tcg ctc ctg ctg       1338
Arg Leu Lys Gln His Pro Arg Pro Pro Ile Pro Leu Ser Leu Leu Leu           
        200                 205                 210                       

aca gaa gag gaa gca gcc ctc tac att caa tcc ttc tgg aga gcc tgt       1386
Thr Glu Glu Glu Ala Ala Leu Tyr Ile Gln Ser Phe Trp Arg Ala Cys           
    215                 220                 225                           

gtg gtt cgc tgt gat cct gag att caa gaa ctg cgt cag tgg cag aag       1434
Val Val Arg Cys Asp Pro Glu Ile Gln Glu Leu Arg Gln Trp Gln Lys           
230                 235                 240                 245           

aaa ctt cgc gag gcc aag cac att cac cag caa gtc aaa att ttc tgg       1482
Lys Leu Arg Glu Ala Lys His Ile His Gln Gln Val Lys Ile Phe Trp           
                250                 255                 260               

gcc aag caa gaa caa aaa gtg aaa tgc aaa atg gag gac gat gca gta       1530
Ala Lys Gln Glu Gln Lys Val Lys Cys Lys Met Glu Asp Asp Ala Val           
            265                 270                 275                   

cct gca gcc aag atg aaa att cca tca tct taa ccatagctaa gacgtatctt     1583
Pro Ala Ala Lys Met Lys Ile Pro Ser Ser                                   
        280                 285                                           

tgcccattcg agcacaagtt accttgtgca aggaaaatgt ccaaatgatg ctctctctct     1643

tgtgatttct ttaacaagac ttggaacatg tgcaaatgga atcttttctg tacaagatag     1703

gattcattgc aaacaagctt taatgcaaat agtttagaaa agaaaggacc agtcttcact     1763

ttctgcatta tccccacatt ttattcattc atccagatta cttcttcagt gcctcaggag     1823

tattcttcta caccagctgc tgttaaaatg tacaatgaac tctagtccca aggaatacag     1883

aagtgctctt attaccagtt ttcccacttg tggccgcctt tgcaaagatc catattctaa     1943

tttaagtccc caacctctga atttggtttt aagtttacct agtgactgac tactctcttt     2003

ataaaaaaga ccttatactt aatgatcatt tccaaaggag accactcctt aacttttact     2063

gcaaacccaa caagatgaga cacttaaacc cagacagatg taacaaagga tttttgttgt     2123

ctaagtccca aagtattata tagaaagttc ctgcttttat gggtaaactt attaccttaa     2183

tatgttctgt ggtttgctgt taaccaagat tctcccattt aaaatgccac agaccgaccc     2243

tcaaggcaga tccgaaagcc tagtagttag ttgcactggg ttgttttgac aagctaccac     2303

acgtcttaag taaatagtaa agcctttatt tttgtgttaa gaacagcatt ttgaaaataa     2363

aacctatctg cccatgcttt acagcctttt aaatttgtaa tatttatata gtcgtttatg     2423

gtacatattg attgtcttga aatttcttta acttcttttt tataagtatg caacagtcag     2483

ccgggggaag ataaaggtac attataaaac acacattaat gcatttaata aatatatatt     2543

atctatcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2603


<210>  464
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  464

Met Ala Ala Pro Arg Gln Ile Pro Ser His Ile Val Arg Leu Lys Pro 
1               5                   10                  15      


Ser Cys Ser Thr Asp Ser Ser Phe Thr Arg Thr Pro Val Pro Thr Val 
            20                  25                  30          


Ser Leu Ala Ser Arg Glu Leu Pro Val Ser Ser Trp Gln Val Thr Glu 
        35                  40                  45              


Pro Ser Ser Lys Asn Leu Trp Glu Gln Ile Cys Lys Glu Tyr Glu Ala 
    50                  55                  60                  


Glu Gln Pro Pro Phe Pro Glu Gly Tyr Lys Val Lys Gln Glu Pro Val 
65                  70                  75                  80  


Ile Thr Val Ala Pro Val Glu Glu Met Leu Phe His Gly Phe Ser Ala 
                85                  90                  95      


Glu His Tyr Phe Pro Val Ser His Phe Thr Met Ile Ser Arg Thr Pro 
            100                 105                 110         


Cys Pro Gln Asp Lys Ser Glu Thr Ile Asn Pro Lys Thr Cys Ser Pro 
        115                 120                 125             


Lys Glu Tyr Leu Glu Thr Phe Ile Phe Pro Val Leu Leu Pro Gly Met 
    130                 135                 140                 


Ala Ser Leu Leu His Gln Ala Lys Lys Glu Lys Cys Phe Glu Arg Lys 
145                 150                 155                 160 


Arg Thr Lys Phe Ile Ala Cys Asp Phe Leu Thr Glu Trp Leu Tyr Asn 
                165                 170                 175     


Gln Asn Pro Lys Arg Ala Gly Glu Pro Phe Thr Glu Phe Phe Ser Ile 
            180                 185                 190         


Pro Phe Val Glu Glu Arg Leu Lys Gln His Pro Arg Pro Pro Ile Pro 
        195                 200                 205             


Leu Ser Leu Leu Leu Thr Glu Glu Glu Ala Ala Leu Tyr Ile Gln Ser 
    210                 215                 220                 


Phe Trp Arg Ala Cys Val Val Arg Cys Asp Pro Glu Ile Gln Glu Leu 
225                 230                 235                 240 


Arg Gln Trp Gln Lys Lys Leu Arg Glu Ala Lys His Ile His Gln Gln 
                245                 250                 255     


Val Lys Ile Phe Trp Ala Lys Gln Glu Gln Lys Val Lys Cys Lys Met 
            260                 265                 270         


Glu Asp Asp Ala Val Pro Ala Ala Lys Met Lys Ile Pro Ser Ser 
        275                 280                 285         


<210>  465
<211>  3396
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (264)..(812)

<400>  465
cattaccaac gaggcgcagg ggtcaggacg actctcggca gcgccattgc gcgccctcta       60

gtggcagccg gttttgaggc cggcctccgg ctttgaagtt cctcaccgcg tctccttccc      120

tctccccaaa gcctggatca ccgcccagcg tcaggcgagg ggcgacgtct cgaggtaaaa      180

cggaggaggt gcgggacgcg gagactgcgc gggcccggta gccctggaga ggccgaggct      240

ctaggccgcg aggggcgggt gca atg gcg gag gaa cag gtg aac cgc agc gcc      293
                          Met Ala Glu Glu Gln Val Asn Arg Ser Ala         
                          1               5                   10          

ggc ctg gcc ccc gac tgt gag gcc tcg gcg act gca gaa act acg gtt        341
Gly Leu Ala Pro Asp Cys Glu Ala Ser Ala Thr Ala Glu Thr Thr Val           
                15                  20                  25                

tcc tca gtg ggg acc tgt gaa gcc gct ggc aag tca cca gag ccc aag        389
Ser Ser Val Gly Thr Cys Glu Ala Ala Gly Lys Ser Pro Glu Pro Lys           
            30                  35                  40                    

gac tac gac agc acc tgc gtg ttc tgc cgg atc gcg ggg cgg cag gac        437
Asp Tyr Asp Ser Thr Cys Val Phe Cys Arg Ile Ala Gly Arg Gln Asp           
        45                  50                  55                        

ccg ggc acc gaa ctc ctg cac tgc gag aat gag gac cta att tgc ttc        485
Pro Gly Thr Glu Leu Leu His Cys Glu Asn Glu Asp Leu Ile Cys Phe           
    60                  65                  70                            

aaa gat atc aaa cca gca gca act cat cat tat ctt gtg gtg cca aag        533
Lys Asp Ile Lys Pro Ala Ala Thr His His Tyr Leu Val Val Pro Lys           
75                  80                  85                  90            

aag cat att gga aac tgc aga act cta agg aaa gat caa gta gaa ctg        581
Lys His Ile Gly Asn Cys Arg Thr Leu Arg Lys Asp Gln Val Glu Leu           
                95                  100                 105               

gtt gag aac atg gta act gtt gga aaa acc att ctt gaa aga aat aat        629
Val Glu Asn Met Val Thr Val Gly Lys Thr Ile Leu Glu Arg Asn Asn           
            110                 115                 120                   

ttc act gac ttc acg aat gtg agg atg ggt ttt cat atg cca cca ttc        677
Phe Thr Asp Phe Thr Asn Val Arg Met Gly Phe His Met Pro Pro Phe           
        125                 130                 135                       

tgt tcc att tcc cac ttg cac ctt cat gtt ctg gca cca gtg gat cag        725
Cys Ser Ile Ser His Leu His Leu His Val Leu Ala Pro Val Asp Gln           
    140                 145                 150                           

ctt ggc ttc tta tcc aag ttg gtt tat aga gtc aat tcc tat tgg ttt        773
Leu Gly Phe Leu Ser Lys Leu Val Tyr Arg Val Asn Ser Tyr Trp Phe           
155                 160                 165                 170           

atc aca gct gat cac ttg att gaa aaa cta aga aca tga aaatgtcaag         822
Ile Thr Ala Asp His Leu Ile Glu Lys Leu Arg Thr                           
                175                 180                                   

agtggaagat ttttctaatc ttggttcagc atgaagtggt atttaggtcc cttttaagtc      882

taattgcaat tttaagattt gttgggtttt atgagaggct gttacttagt ggccttaaat      942

cttttctgaa tgtctgtttc ctaagatctg tgatacagtt atgtgaatat tttgttactg     1002

acttgtttca atggttactt gtataaggat tttatatata tgatactata gataaaatcc     1062

tatttaagac aaattctgtt aatcaacaag ggctctgtat ttttttaagt taaaatattt     1122

tcatttctca gtaagtagtc agttataata gtgatttatt tatgaagaat aaactactat     1182

agaaagtact ttgtgggaac ctttattact gtgaaggaga aaaatagcta tttcttgaca     1242

gttctatagt tatacacata aattttcaaa ataaagaata ccatactaca caatgatctc     1302

tgattttgct gagggaagga attatatatg tgccactttt tcctcaaatt tcagatgcca     1362

gttttcactt tttgaagcat tgcatctttt taataaatct atcctgaaag ctatataata     1422

tatataattt atatcaatga atttacaata actatcaaat tggctatcag aattcactgt     1482

aatggaattt tgcctctaat aacataaagg gggaagaaac ataaagtggt tctcttaata     1542

aaactagcag aaaatgttgc tttatggcat gtttttgtat caaagagaaa tcagaggtta     1602

aactttgctt ttatcatgaa aagggcctga tttgaaggta gagataggct tagatgagaa     1662

aaattgataa cgcaatgtta atactattga tatttcatag gtatattttg ttagaaattg     1722

gttttttggt gctaatctat aggcacaata gtgaatatga atgaagagta ggtgctgcaa     1782

gttaatccta cattgtgcca gtgtatatta gtaccatgta aatgaatatg aataaatgaa     1842

catgaggatt aacgaactgt tgaaaatagg ctgagatact agttttcttt cttttttaga     1902

gggggcatga tattaaagat agttttaagt aacaaattac ttattacaaa gttacaacat     1962

gtggaatcaa tagttttatt tgttcattaa tttattcatt cagcaaacat ttgttgaaca     2022

tttaatgtgt accagatatt gccaggatca ggaaataaag aactaaaaat ggacattcag     2082

actgcaattg ctagtacagg ggtcaaacaa aatcagtgat tagaatttag tgcgttaagt     2142

tccctgatgc cttcacagcc agaagaggct gtgaagggat aaacacttct gagagtgggt     2202

ggtagtagaa ctgagtattc aagactgaat gttaggcagg tagacagtga ctggttaggc     2262

tgagaaactt acaagtattt tcgttgagtt ctgcttccac tattatttac tttacaatgg     2322

atatgaagtt cagatttcat cttatttact gaaggtggag aaaggatgtg gaagtagggg     2382

ttatgggctc tcaaaagtag atttagagag atttttttat cactgtttta tgatatagtt     2442

cactgagcac ttacatagat taacagttac aagtttccat aaatcagtta gaatatgact     2502

agcttcaggg aaggaatttt caacaactgc aatctttgat tgttttactg tgggaacttg     2562

cagtgatata attgacaaca ttatttaaca ataataggta aagtaggccg ggtgtggtgg     2622

ctcacgcctg taatcctagc actttgggag gccgaggtgg gtggatcaca aggtcaggag     2682

ttcgagacca gcctggccaa tatggtgaaa ccccgtctct tctaaaaaaa tacaaaaatt     2742

agccgggtat ggtggcgcat gcctgtagtc ccagctactg gggaggctga ggcaagagaa     2802

ttgcttgaac tcgggaggcg gaggtcgcag tgagccgaga tcgtgccact gcactccagc     2862

ctgggtgaca gagtgagact ttgtctcaaa gaaaaaaaaa caataatagg taaagtattt     2922

aaggaattct cagatgcctt atggacctct tcaaaaatgt ggttagccaa ttgattcaac     2982

ttttataggt ttatatgctc tcatgtaaac ctatttgttt ccgagatcag acgagatcgg     3042

gcgcgttcag ggtggtatgg ccgtagacaa cctatttgtt aaaaaccctt ggaaacacat     3102

cttttagtag aggttcttat ttacttataa agattaataa tcaaattact acaattaata     3162

tccatttagc cttttcagta gtctaaatat ttggtaactc cctagccatc tataacacta     3222

gttcaaaaca aggctaattc ataacctgtc ttaaaaatgt ttgaagtggt atcaagagca     3282

ttgtttatgc atgttgtgat actatttgtg gaactgttta atgagctatt tcaaactgct     3342

agaagaaaat gaaataaaaa tggaaaaata ctgtcaaaaa aaaaaaaaaa aaaa           3396


<210>  466
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  466

Met Ala Glu Glu Gln Val Asn Arg Ser Ala Gly Leu Ala Pro Asp Cys 
1               5                   10                  15      


Glu Ala Ser Ala Thr Ala Glu Thr Thr Val Ser Ser Val Gly Thr Cys 
            20                  25                  30          


Glu Ala Ala Gly Lys Ser Pro Glu Pro Lys Asp Tyr Asp Ser Thr Cys 
        35                  40                  45              


Val Phe Cys Arg Ile Ala Gly Arg Gln Asp Pro Gly Thr Glu Leu Leu 
    50                  55                  60                  


His Cys Glu Asn Glu Asp Leu Ile Cys Phe Lys Asp Ile Lys Pro Ala 
65                  70                  75                  80  


Ala Thr His His Tyr Leu Val Val Pro Lys Lys His Ile Gly Asn Cys 
                85                  90                  95      


Arg Thr Leu Arg Lys Asp Gln Val Glu Leu Val Glu Asn Met Val Thr 
            100                 105                 110         


Val Gly Lys Thr Ile Leu Glu Arg Asn Asn Phe Thr Asp Phe Thr Asn 
        115                 120                 125             


Val Arg Met Gly Phe His Met Pro Pro Phe Cys Ser Ile Ser His Leu 
    130                 135                 140                 


His Leu His Val Leu Ala Pro Val Asp Gln Leu Gly Phe Leu Ser Lys 
145                 150                 155                 160 


Leu Val Tyr Arg Val Asn Ser Tyr Trp Phe Ile Thr Ala Asp His Leu 
                165                 170                 175     


Ile Glu Lys Leu Arg Thr 
            180         


<210>  467
<211>  1987
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (223)..(1701)

<400>  467
agccgccgcc gtctccgccg tcgctggggc agctgccgcg gtggtcgcct ctggcagtgc       60

cgctagcttt caggcagtcg cctctcctcc cgacatcccg ccttgaggag gctgaggcgg      120

aatcgcggct ggcggcgggg ggacggaccg gccctgcagt ggccgcagtg acagcccgga      180

cccggccctc cgcccgctct cgcctcggcg cccgcagcca cg atg aac cgg ggc         234
                                               Met Asn Arg Gly            
                                               1                          

ggc ggc agc ccg tcg gcc gcc gcc aac tac ctg ctc tgt acc aac tgc        282
Gly Gly Ser Pro Ser Ala Ala Ala Asn Tyr Leu Leu Cys Thr Asn Cys           
5                   10                  15                  20            

cgg aaa gtg ctg cgg aag gat aaa aga atc aga gtg tct caa ccc ttg        330
Arg Lys Val Leu Arg Lys Asp Lys Arg Ile Arg Val Ser Gln Pro Leu           
                25                  30                  35                

aca aga gga cca agt gcc ttt att cca gag aag gaa gtt gtc caa gca        378
Thr Arg Gly Pro Ser Ala Phe Ile Pro Glu Lys Glu Val Val Gln Ala           
            40                  45                  50                    

aac aca gtg gat gaa cgt act aac ttt ctt gtg gaa gaa tac tct aca        426
Asn Thr Val Asp Glu Arg Thr Asn Phe Leu Val Glu Glu Tyr Ser Thr           
        55                  60                  65                        

tcc ggt cgt ctg gac aac atc aca cag gtc atg agt tta cac act cag        474
Ser Gly Arg Leu Asp Asn Ile Thr Gln Val Met Ser Leu His Thr Gln           
    70                  75                  80                            

tac ctg gag tct ttc ttg cgg agc cag ttt tac atg ttg cgc atg gat        522
Tyr Leu Glu Ser Phe Leu Arg Ser Gln Phe Tyr Met Leu Arg Met Asp           
85                  90                  95                  100           

ggt ccc ctt cct cta cca tac agg cac tat att gca ata atg gct gca        570
Gly Pro Leu Pro Leu Pro Tyr Arg His Tyr Ile Ala Ile Met Ala Ala           
                105                 110                 115               

gct aga cat cag tgt tct tac tta ata aac atg cat gtg gat gaa ttt        618
Ala Arg His Gln Cys Ser Tyr Leu Ile Asn Met His Val Asp Glu Phe           
            120                 125                 130                   

tta aag act gga ggt att gct gag tgg ttg aat ggt ttg gaa tat gtg        666
Leu Lys Thr Gly Gly Ile Ala Glu Trp Leu Asn Gly Leu Glu Tyr Val           
        135                 140                 145                       

cca caa aga ctg aaa aat ctt aat gaa att aat aag ctg cta gca cat        714
Pro Gln Arg Leu Lys Asn Leu Asn Glu Ile Asn Lys Leu Leu Ala His           
    150                 155                 160                           

cga cct tgg ctg atc aca aaa gag cac att cag aaa ctt gtc aaa act        762
Arg Pro Trp Leu Ile Thr Lys Glu His Ile Gln Lys Leu Val Lys Thr           
165                 170                 175                 180           

gga gaa aat aat tgg tct ctg cct gaa ctg gta cat gct gtg gtc ctc        810
Gly Glu Asn Asn Trp Ser Leu Pro Glu Leu Val His Ala Val Val Leu           
                185                 190                 195               

ctg gca cat tat cat gct ttg gca agc ttt gtt ttt ggt agt ggt atc        858
Leu Ala His Tyr His Ala Leu Ala Ser Phe Val Phe Gly Ser Gly Ile           
            200                 205                 210                   

aat cca gag aga gat cca gaa atc tcc aat gga ttc agg cta ata tca        906
Asn Pro Glu Arg Asp Pro Glu Ile Ser Asn Gly Phe Arg Leu Ile Ser           
        215                 220                 225                       

gtc aac aat ttc tgc gtt tgt gat ctt gct aat gac aac aac ata gag        954
Val Asn Asn Phe Cys Val Cys Asp Leu Ala Asn Asp Asn Asn Ile Glu           
    230                 235                 240                           

aat gca tct ctt tca ggc agc aac ttt ggg att gtg gat tct cta agt       1002
Asn Ala Ser Leu Ser Gly Ser Asn Phe Gly Ile Val Asp Ser Leu Ser           
245                 250                 255                 260           

gag cta gag gcc tta atg gaa agg atg aaa aga ctt caa gaa gaa agg       1050
Glu Leu Glu Ala Leu Met Glu Arg Met Lys Arg Leu Gln Glu Glu Arg           
                265                 270                 275               

gaa gat gaa gag gcg tct caa gaa gaa atg agc act cgt ttt gaa aag       1098
Glu Asp Glu Glu Ala Ser Gln Glu Glu Met Ser Thr Arg Phe Glu Lys           
            280                 285                 290                   

gag aag aaa gaa agt ctt ttt gtg gtc tct gga gat act ttt cat tca       1146
Glu Lys Lys Glu Ser Leu Phe Val Val Ser Gly Asp Thr Phe His Ser           
        295                 300                 305                       

ttt cct cat tca gat ttt gag gat gac atg att ata aca tct gat gtc       1194
Phe Pro His Ser Asp Phe Glu Asp Asp Met Ile Ile Thr Ser Asp Val           
    310                 315                 320                           

tct cga tat att gaa gac cct ggt ttt ggg tat gaa gac ttt gcc aga       1242
Ser Arg Tyr Ile Glu Asp Pro Gly Phe Gly Tyr Glu Asp Phe Ala Arg           
325                 330                 335                 340           

cga gga gaa gag cat ttg cca aca ttc cga gct cag gac tat acc tgg       1290
Arg Gly Glu Glu His Leu Pro Thr Phe Arg Ala Gln Asp Tyr Thr Trp           
                345                 350                 355               

gaa aat cat ggg ttc tcc ctg gtg aac aga ctt tat tct gac att gga       1338
Glu Asn His Gly Phe Ser Leu Val Asn Arg Leu Tyr Ser Asp Ile Gly           
            360                 365                 370                   

cat ctt ctt gat gaa aag ttt cgg atg gtc tac aat ctc aca tat aac       1386
His Leu Leu Asp Glu Lys Phe Arg Met Val Tyr Asn Leu Thr Tyr Asn           
        375                 380                 385                       

act atg gcc acc cat gag gat gtt gac aca acc atg ctg cgc aga gct       1434
Thr Met Ala Thr His Glu Asp Val Asp Thr Thr Met Leu Arg Arg Ala           
    390                 395                 400                           

tta ttt aac tat gtt cac tgt atg ttt gga atc agg tat gat gac tat       1482
Leu Phe Asn Tyr Val His Cys Met Phe Gly Ile Arg Tyr Asp Asp Tyr           
405                 410                 415                 420           

gat tat gga gaa gtt aat caa tta ctt gaa aga agc ctg aag gtt tac       1530
Asp Tyr Gly Glu Val Asn Gln Leu Leu Glu Arg Ser Leu Lys Val Tyr           
                425                 430                 435               

att aag aca gtg acc tgc tat cct gag aga act aca aaa cgc atg tat       1578
Ile Lys Thr Val Thr Cys Tyr Pro Glu Arg Thr Thr Lys Arg Met Tyr           
            440                 445                 450                   

gat agt tac tgg cgg cag ttc aaa cac tca gaa aaa gtt cat gtc aat       1626
Asp Ser Tyr Trp Arg Gln Phe Lys His Ser Glu Lys Val His Val Asn           
        455                 460                 465                       

cta ctt tta atg gaa gca cga atg caa gct gaa ctt ctt tat gct ctt       1674
Leu Leu Leu Met Glu Ala Arg Met Gln Ala Glu Leu Leu Tyr Ala Leu           
    470                 475                 480                           

cgt gcc ata act cgg cat ttg acc tga agtatcaccc aaggaaaatg             1721
Arg Ala Ile Thr Arg His Leu Thr                                           
485                 490                                                   

tcatacatgt gtaaagacct ttcacataag ataaacattg aagctatttg tgatatagca     1781

tcaaaaatta ttcagttctc tagtgtcaaa gtttagccgt ttgttttttt ttttttgttt     1841

tttgcggctg taatgtgcaa tgatgtgttt tattttcctt gatgcttaac attactaaca     1901

attgcaaaaa taatactgag gagcactact ttgcattgtt tgtagttgga gttttggata     1961

ctgatcataa atcatgaatc tggcgt                                          1987


<210>  468
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  468

Met Asn Arg Gly Gly Gly Ser Pro Ser Ala Ala Ala Asn Tyr Leu Leu 
1               5                   10                  15      


Cys Thr Asn Cys Arg Lys Val Leu Arg Lys Asp Lys Arg Ile Arg Val 
            20                  25                  30          


Ser Gln Pro Leu Thr Arg Gly Pro Ser Ala Phe Ile Pro Glu Lys Glu 
        35                  40                  45              


Val Val Gln Ala Asn Thr Val Asp Glu Arg Thr Asn Phe Leu Val Glu 
    50                  55                  60                  


Glu Tyr Ser Thr Ser Gly Arg Leu Asp Asn Ile Thr Gln Val Met Ser 
65                  70                  75                  80  


Leu His Thr Gln Tyr Leu Glu Ser Phe Leu Arg Ser Gln Phe Tyr Met 
                85                  90                  95      


Leu Arg Met Asp Gly Pro Leu Pro Leu Pro Tyr Arg His Tyr Ile Ala 
            100                 105                 110         


Ile Met Ala Ala Ala Arg His Gln Cys Ser Tyr Leu Ile Asn Met His 
        115                 120                 125             


Val Asp Glu Phe Leu Lys Thr Gly Gly Ile Ala Glu Trp Leu Asn Gly 
    130                 135                 140                 


Leu Glu Tyr Val Pro Gln Arg Leu Lys Asn Leu Asn Glu Ile Asn Lys 
145                 150                 155                 160 


Leu Leu Ala His Arg Pro Trp Leu Ile Thr Lys Glu His Ile Gln Lys 
                165                 170                 175     


Leu Val Lys Thr Gly Glu Asn Asn Trp Ser Leu Pro Glu Leu Val His 
            180                 185                 190         


Ala Val Val Leu Leu Ala His Tyr His Ala Leu Ala Ser Phe Val Phe 
        195                 200                 205             


Gly Ser Gly Ile Asn Pro Glu Arg Asp Pro Glu Ile Ser Asn Gly Phe 
    210                 215                 220                 


Arg Leu Ile Ser Val Asn Asn Phe Cys Val Cys Asp Leu Ala Asn Asp 
225                 230                 235                 240 


Asn Asn Ile Glu Asn Ala Ser Leu Ser Gly Ser Asn Phe Gly Ile Val 
                245                 250                 255     


Asp Ser Leu Ser Glu Leu Glu Ala Leu Met Glu Arg Met Lys Arg Leu 
            260                 265                 270         


Gln Glu Glu Arg Glu Asp Glu Glu Ala Ser Gln Glu Glu Met Ser Thr 
        275                 280                 285             


Arg Phe Glu Lys Glu Lys Lys Glu Ser Leu Phe Val Val Ser Gly Asp 
    290                 295                 300                 


Thr Phe His Ser Phe Pro His Ser Asp Phe Glu Asp Asp Met Ile Ile 
305                 310                 315                 320 


Thr Ser Asp Val Ser Arg Tyr Ile Glu Asp Pro Gly Phe Gly Tyr Glu 
                325                 330                 335     


Asp Phe Ala Arg Arg Gly Glu Glu His Leu Pro Thr Phe Arg Ala Gln 
            340                 345                 350         


Asp Tyr Thr Trp Glu Asn His Gly Phe Ser Leu Val Asn Arg Leu Tyr 
        355                 360                 365             


Ser Asp Ile Gly His Leu Leu Asp Glu Lys Phe Arg Met Val Tyr Asn 
    370                 375                 380                 


Leu Thr Tyr Asn Thr Met Ala Thr His Glu Asp Val Asp Thr Thr Met 
385                 390                 395                 400 


Leu Arg Arg Ala Leu Phe Asn Tyr Val His Cys Met Phe Gly Ile Arg 
                405                 410                 415     


Tyr Asp Asp Tyr Asp Tyr Gly Glu Val Asn Gln Leu Leu Glu Arg Ser 
            420                 425                 430         


Leu Lys Val Tyr Ile Lys Thr Val Thr Cys Tyr Pro Glu Arg Thr Thr 
        435                 440                 445             


Lys Arg Met Tyr Asp Ser Tyr Trp Arg Gln Phe Lys His Ser Glu Lys 
    450                 455                 460                 


Val His Val Asn Leu Leu Leu Met Glu Ala Arg Met Gln Ala Glu Leu 
465                 470                 475                 480 


Leu Tyr Ala Leu Arg Ala Ile Thr Arg His Leu Thr 
                485                 490         


<210>  469
<211>  901
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (93)..(776)

<400>  469
cccaaagtac ttgtgtccgg gtggtggact ggattagctg cggagccctg gaagctgcct       60

gtccttctcc ctgtgcttaa ccagaggtgc cc atg ggt tgg aca atg agg ctg        113
                                    Met Gly Trp Thr Met Arg Leu           
                                    1               5                     

gtc aca gca gca ctg tta ctg ggt ctc atg atg gtg gtc act gga gac        161
Val Thr Ala Ala Leu Leu Leu Gly Leu Met Met Val Val Thr Gly Asp           
        10                  15                  20                        

gag gat gag aac agc ccg tgt gcc cat gag gcc ctc ttg gac gag gac        209
Glu Asp Glu Asn Ser Pro Cys Ala His Glu Ala Leu Leu Asp Glu Asp           
    25                  30                  35                            

acc ctc ttt tgc cag ggc ctt gaa gtt ttc tac cca gag ttg ggg aac        257
Thr Leu Phe Cys Gln Gly Leu Glu Val Phe Tyr Pro Glu Leu Gly Asn           
40                  45                  50                  55            

att ggc tgc aag gtt gtt cct gat tgt aac aac tac aga cag aag atc        305
Ile Gly Cys Lys Val Val Pro Asp Cys Asn Asn Tyr Arg Gln Lys Ile           
                60                  65                  70                

acc tcc tgg atg gag ccg ata gtc aag ttc ccg ggg gcc gtg gac ggc        353
Thr Ser Trp Met Glu Pro Ile Val Lys Phe Pro Gly Ala Val Asp Gly           
            75                  80                  85                    

gca acc tat atc ctg gtg atg gtg gat cca gat gcc cct agc aga gca        401
Ala Thr Tyr Ile Leu Val Met Val Asp Pro Asp Ala Pro Ser Arg Ala           
        90                  95                  100                       

gaa ccc aga cag aga ttc tgg aga cat tgg ctg gta aca gat atc aag        449
Glu Pro Arg Gln Arg Phe Trp Arg His Trp Leu Val Thr Asp Ile Lys           
    105                 110                 115                           

ggc gcc gac ctg aag aaa ggg aag att cag ggc cag gag tta tca gcc        497
Gly Ala Asp Leu Lys Lys Gly Lys Ile Gln Gly Gln Glu Leu Ser Ala           
120                 125                 130                 135           

tac cag gct ccc tcc cca ccg gca cac agt ggc ttc cat cgc tac cag        545
Tyr Gln Ala Pro Ser Pro Pro Ala His Ser Gly Phe His Arg Tyr Gln           
                140                 145                 150               

ttc ttt gtc tat ctt cag gaa gga aaa gtc atc tct ctc ctt ccc aag        593
Phe Phe Val Tyr Leu Gln Glu Gly Lys Val Ile Ser Leu Leu Pro Lys           
            155                 160                 165                   

gaa aac aaa act cga ggc tct tgg aaa atg gac aga ttt ctg aac cgt        641
Glu Asn Lys Thr Arg Gly Ser Trp Lys Met Asp Arg Phe Leu Asn Arg           
        170                 175                 180                       

ttc cac ctg ggc gaa cct gaa gca agc acc cag ttc atg acc cag aac        689
Phe His Leu Gly Glu Pro Glu Ala Ser Thr Gln Phe Met Thr Gln Asn           
    185                 190                 195                           

tac cag gac tca cca acc ctc cag gct ccc aga gaa agg gcc agc gag        737
Tyr Gln Asp Ser Pro Thr Leu Gln Ala Pro Arg Glu Arg Ala Ser Glu           
200                 205                 210                 215           

ccc aag cac aaa aac cag gcg gag ata gct gcc tgc tag atagccggct         786
Pro Lys His Lys Asn Gln Ala Glu Ile Ala Ala Cys                           
                220                 225                                   

ttgccatccg ggcatgtggc cacactgccc accaccgacg atgtgggtat ggaaccccct      846

ctggatacag aaccccttct tttccaaata aaaaaaaaat catccaggaa aaaaa           901


<210>  470
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  470

Met Gly Trp Thr Met Arg Leu Val Thr Ala Ala Leu Leu Leu Gly Leu 
1               5                   10                  15      


Met Met Val Val Thr Gly Asp Glu Asp Glu Asn Ser Pro Cys Ala His 
            20                  25                  30          


Glu Ala Leu Leu Asp Glu Asp Thr Leu Phe Cys Gln Gly Leu Glu Val 
        35                  40                  45              


Phe Tyr Pro Glu Leu Gly Asn Ile Gly Cys Lys Val Val Pro Asp Cys 
    50                  55                  60                  


Asn Asn Tyr Arg Gln Lys Ile Thr Ser Trp Met Glu Pro Ile Val Lys 
65                  70                  75                  80  


Phe Pro Gly Ala Val Asp Gly Ala Thr Tyr Ile Leu Val Met Val Asp 
                85                  90                  95      


Pro Asp Ala Pro Ser Arg Ala Glu Pro Arg Gln Arg Phe Trp Arg His 
            100                 105                 110         


Trp Leu Val Thr Asp Ile Lys Gly Ala Asp Leu Lys Lys Gly Lys Ile 
        115                 120                 125             


Gln Gly Gln Glu Leu Ser Ala Tyr Gln Ala Pro Ser Pro Pro Ala His 
    130                 135                 140                 


Ser Gly Phe His Arg Tyr Gln Phe Phe Val Tyr Leu Gln Glu Gly Lys 
145                 150                 155                 160 


Val Ile Ser Leu Leu Pro Lys Glu Asn Lys Thr Arg Gly Ser Trp Lys 
                165                 170                 175     


Met Asp Arg Phe Leu Asn Arg Phe His Leu Gly Glu Pro Glu Ala Ser 
            180                 185                 190         


Thr Gln Phe Met Thr Gln Asn Tyr Gln Asp Ser Pro Thr Leu Gln Ala 
        195                 200                 205             


Pro Arg Glu Arg Ala Ser Glu Pro Lys His Lys Asn Gln Ala Glu Ile 
    210                 215                 220                 


Ala Ala Cys 
225         


<210>  471
<211>  2567
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (354)..(2060)

<400>  471
gggagcgcgg cgcggccgcc gcgtgcgcga gccggggttg cagcccagcc gggactttcc       60

agccggcggc agccgcggcg gccgccggct cttccccgcc ccccgtcatg gggcagcccg      120

gggagcagaa cgctgcggac cgcggcggag gacgcgcccg gcgcccctga gccggccgag      180

cggcgacgga ccgcgagatg aggaaaatga ggcccaaaga agtgatgcca cttggttaag      240

gtcccagagc aggtcagaat cagacctagg atcagaaacc tggctcctgg ctcctggctc      300

cctactcttc taaggatcgc tgtcctgaca gaagagaact cctctttcct aaa atg         356
                                                           Met            
                                                           1              

gag tcg agt aaa aag atg gac tct cct ggc gcg ctg cag act aac ccg        404
Glu Ser Ser Lys Lys Met Asp Ser Pro Gly Ala Leu Gln Thr Asn Pro           
            5                   10                  15                    

ccg cta aag ctg cac act gac cgc agt gct ggg acg cca gtt ttt gtc        452
Pro Leu Lys Leu His Thr Asp Arg Ser Ala Gly Thr Pro Val Phe Val           
        20                  25                  30                        

cct gaa caa gga ggt tac aag gaa aag ttt gtg aag acc gtg gag gac        500
Pro Glu Gln Gly Gly Tyr Lys Glu Lys Phe Val Lys Thr Val Glu Asp           
    35                  40                  45                            

aag tac aag tgt gag aag tgc cac ctg gtg ctg tgc agc ccg aag cag        548
Lys Tyr Lys Cys Glu Lys Cys His Leu Val Leu Cys Ser Pro Lys Gln           
50                  55                  60                  65            

acc gag tgt ggg cac cgc ttc tgc gag agc tgc atg gcg gcc ctg ctg        596
Thr Glu Cys Gly His Arg Phe Cys Glu Ser Cys Met Ala Ala Leu Leu           
                70                  75                  80                

agc tct tca agt cca aaa tgt aca gcg tgt caa gag agc atc gtt aaa        644
Ser Ser Ser Ser Pro Lys Cys Thr Ala Cys Gln Glu Ser Ile Val Lys           
            85                  90                  95                    

gat aag gtg ttt aag gat aat tgc tgc aag aga gaa att ctg gct ctt        692
Asp Lys Val Phe Lys Asp Asn Cys Cys Lys Arg Glu Ile Leu Ala Leu           
        100                 105                 110                       

cag atc tat tgt cgg aat gaa agc aga ggt tgt gca gag cag tta atg        740
Gln Ile Tyr Cys Arg Asn Glu Ser Arg Gly Cys Ala Glu Gln Leu Met           
    115                 120                 125                           

ctg gga cat ctg ctg gtg cat tta aaa aat gat tgc cat ttt gaa gaa        788
Leu Gly His Leu Leu Val His Leu Lys Asn Asp Cys His Phe Glu Glu           
130                 135                 140                 145           

ctt cca tgt gtg cgt cct gac tgc aaa gaa aag gtc ttg agg aaa gac        836
Leu Pro Cys Val Arg Pro Asp Cys Lys Glu Lys Val Leu Arg Lys Asp           
                150                 155                 160               

ctg cga gac cac gtg gag aag gcg tgt aaa tac cgg gaa gcc aca tgc        884
Leu Arg Asp His Val Glu Lys Ala Cys Lys Tyr Arg Glu Ala Thr Cys           
            165                 170                 175                   

agc cac tgc aag agt cag gtt ccg atg atc gcg ctg cag aaa cac gaa        932
Ser His Cys Lys Ser Gln Val Pro Met Ile Ala Leu Gln Lys His Glu           
        180                 185                 190                       

gac acc gac tgt ccc tgc gtg gtg gtg tcc tgc cct cac aag tgc agc        980
Asp Thr Asp Cys Pro Cys Val Val Val Ser Cys Pro His Lys Cys Ser           
    195                 200                 205                           

gtc cag act ctc ctg agg agc gag ttg agt gca cac ttg tca gag tgt       1028
Val Gln Thr Leu Leu Arg Ser Glu Leu Ser Ala His Leu Ser Glu Cys           
210                 215                 220                 225           

gtc aat gcc ccc agc acc tgt agt ttt aag cgc tat ggc tgc gtt ttt       1076
Val Asn Ala Pro Ser Thr Cys Ser Phe Lys Arg Tyr Gly Cys Val Phe           
                230                 235                 240               

cag ggg aca aac cag cag atc aag gcc cac gag gcc agc tcc gcc gtg       1124
Gln Gly Thr Asn Gln Gln Ile Lys Ala His Glu Ala Ser Ser Ala Val           
            245                 250                 255                   

cag cac gtc aac ctg ctg aag gag tgg agc aac tcg ctc gaa aag aag       1172
Gln His Val Asn Leu Leu Lys Glu Trp Ser Asn Ser Leu Glu Lys Lys           
        260                 265                 270                       

gtt tcc ttg ttg cag aat gaa agt gta gaa aaa aac aag agc ata caa       1220
Val Ser Leu Leu Gln Asn Glu Ser Val Glu Lys Asn Lys Ser Ile Gln           
    275                 280                 285                           

agt ttg cac aat cag ata tgt agc ttt gaa att gaa att gag aga caa       1268
Ser Leu His Asn Gln Ile Cys Ser Phe Glu Ile Glu Ile Glu Arg Gln           
290                 295                 300                 305           

aag gaa atg ctt cga aat aat gaa tcc aaa atc ctt cat tta cag cga       1316
Lys Glu Met Leu Arg Asn Asn Glu Ser Lys Ile Leu His Leu Gln Arg           
                310                 315                 320               

gtg ata gac agc caa gca gag aaa ctg aag gag ctt gac aag gag atc       1364
Val Ile Asp Ser Gln Ala Glu Lys Leu Lys Glu Leu Asp Lys Glu Ile           
            325                 330                 335                   

cgg ccc ttc cgg cag aac tgg gag gaa gca gac agc atg aag agc agc       1412
Arg Pro Phe Arg Gln Asn Trp Glu Glu Ala Asp Ser Met Lys Ser Ser           
        340                 345                 350                       

gtg gag tcc ctc cag aac cgc gtg acc gag ctg gag agc gtg gac aag       1460
Val Glu Ser Leu Gln Asn Arg Val Thr Glu Leu Glu Ser Val Asp Lys           
    355                 360                 365                           

agc gcg ggg caa gtg gct cgg aac aca ggc ctg ctg gag tcc cag ctg       1508
Ser Ala Gly Gln Val Ala Arg Asn Thr Gly Leu Leu Glu Ser Gln Leu           
370                 375                 380                 385           

agc cgg cat gac cag atg ctg agt gtg cac gac atc cgc cta gcc gac       1556
Ser Arg His Asp Gln Met Leu Ser Val His Asp Ile Arg Leu Ala Asp           
                390                 395                 400               

atg gac ctg cgc ttc cag gtc ctg gag acc gcc agc tac aat gga gtg       1604
Met Asp Leu Arg Phe Gln Val Leu Glu Thr Ala Ser Tyr Asn Gly Val           
            405                 410                 415                   

ctc atc tgg aag att cgc gac tac aag cgg cgg aag cag gag gcc gtc       1652
Leu Ile Trp Lys Ile Arg Asp Tyr Lys Arg Arg Lys Gln Glu Ala Val           
        420                 425                 430                       

atg ggg aag acc ctg tcc ctt tac agc cag cct ttc tac act ggt tac       1700
Met Gly Lys Thr Leu Ser Leu Tyr Ser Gln Pro Phe Tyr Thr Gly Tyr           
    435                 440                 445                           

ttt ggc tat aag atg tgt gcc agg gtc tac ctg aac ggg gac ggg atg       1748
Phe Gly Tyr Lys Met Cys Ala Arg Val Tyr Leu Asn Gly Asp Gly Met           
450                 455                 460                 465           

ggg aag ggg acg cac ttg tcg ctg ttt ttt gtc atc atg cgt gga gaa       1796
Gly Lys Gly Thr His Leu Ser Leu Phe Phe Val Ile Met Arg Gly Glu           
                470                 475                 480               

tat gat gcc ctg ctt cct tgg ccg ttt aag cag aaa gtg aca ctc atg       1844
Tyr Asp Ala Leu Leu Pro Trp Pro Phe Lys Gln Lys Val Thr Leu Met           
            485                 490                 495                   

ctg atg gat cag ggg tcc tct cga cgt cat ttg gga gat gca ttc aag       1892
Leu Met Asp Gln Gly Ser Ser Arg Arg His Leu Gly Asp Ala Phe Lys           
        500                 505                 510                       

ccc gac ccc aac agc agc agc ttc aag aag ccc act gga gag atg aat       1940
Pro Asp Pro Asn Ser Ser Ser Phe Lys Lys Pro Thr Gly Glu Met Asn           
    515                 520                 525                           

atc gcc tct ggc tgc cca gtc ttt gtg gcc caa act gtt cta gaa aat       1988
Ile Ala Ser Gly Cys Pro Val Phe Val Ala Gln Thr Val Leu Glu Asn           
530                 535                 540                 545           

ggg aca tat att aaa gat gat aca att ttt att aaa gtc ata gtg gat       2036
Gly Thr Tyr Ile Lys Asp Asp Thr Ile Phe Ile Lys Val Ile Val Asp           
                550                 555                 560               

act tcg gat ctg ccc gat ccc tga taagtagctg gggaggtgga tttagcagaa      2090
Thr Ser Asp Leu Pro Asp Pro                                               
            565                                                           

ggcaactcct ctgggggatt tgaaccggtc tgtcttcact gaggtcctcg cgctcagaaa     2150

aggaccttgt gagacggagg aagcggcaga aggcggacgc gtgccggcgg gaggagccac     2210

gcgtgagcac acctgacacg ttttataata gactagccac acttcactct gaagaattat     2270

ttatccttca acaagataaa tattgctgtc agagaaggtt ttcattttca tttttaaaga     2330

tctagttaat taaggtggaa aacatatatg ctaaacaaaa gaaacatgat ttttcttcct     2390

taaacttgaa caccaaaaaa acacacacac acacacacgt ggggatagct ggacatgtca     2450

gcatgttaag taaaaggaga atttatgaaa tagtaatgca attctgatat cttctttcta     2510

aaattcaaga gtgcaatttt gtttcaaata cagtatattg tctattttta aggcctc        2567


<210>  472
<211>  568
<212>  PRT
<213>  Homo sapiens

<400>  472

Met Glu Ser Ser Lys Lys Met Asp Ser Pro Gly Ala Leu Gln Thr Asn 
1               5                   10                  15      


Pro Pro Leu Lys Leu His Thr Asp Arg Ser Ala Gly Thr Pro Val Phe 
            20                  25                  30          


Val Pro Glu Gln Gly Gly Tyr Lys Glu Lys Phe Val Lys Thr Val Glu 
        35                  40                  45              


Asp Lys Tyr Lys Cys Glu Lys Cys His Leu Val Leu Cys Ser Pro Lys 
    50                  55                  60                  


Gln Thr Glu Cys Gly His Arg Phe Cys Glu Ser Cys Met Ala Ala Leu 
65                  70                  75                  80  


Leu Ser Ser Ser Ser Pro Lys Cys Thr Ala Cys Gln Glu Ser Ile Val 
                85                  90                  95      


Lys Asp Lys Val Phe Lys Asp Asn Cys Cys Lys Arg Glu Ile Leu Ala 
            100                 105                 110         


Leu Gln Ile Tyr Cys Arg Asn Glu Ser Arg Gly Cys Ala Glu Gln Leu 
        115                 120                 125             


Met Leu Gly His Leu Leu Val His Leu Lys Asn Asp Cys His Phe Glu 
    130                 135                 140                 


Glu Leu Pro Cys Val Arg Pro Asp Cys Lys Glu Lys Val Leu Arg Lys 
145                 150                 155                 160 


Asp Leu Arg Asp His Val Glu Lys Ala Cys Lys Tyr Arg Glu Ala Thr 
                165                 170                 175     


Cys Ser His Cys Lys Ser Gln Val Pro Met Ile Ala Leu Gln Lys His 
            180                 185                 190         


Glu Asp Thr Asp Cys Pro Cys Val Val Val Ser Cys Pro His Lys Cys 
        195                 200                 205             


Ser Val Gln Thr Leu Leu Arg Ser Glu Leu Ser Ala His Leu Ser Glu 
    210                 215                 220                 


Cys Val Asn Ala Pro Ser Thr Cys Ser Phe Lys Arg Tyr Gly Cys Val 
225                 230                 235                 240 


Phe Gln Gly Thr Asn Gln Gln Ile Lys Ala His Glu Ala Ser Ser Ala 
                245                 250                 255     


Val Gln His Val Asn Leu Leu Lys Glu Trp Ser Asn Ser Leu Glu Lys 
            260                 265                 270         


Lys Val Ser Leu Leu Gln Asn Glu Ser Val Glu Lys Asn Lys Ser Ile 
        275                 280                 285             


Gln Ser Leu His Asn Gln Ile Cys Ser Phe Glu Ile Glu Ile Glu Arg 
    290                 295                 300                 


Gln Lys Glu Met Leu Arg Asn Asn Glu Ser Lys Ile Leu His Leu Gln 
305                 310                 315                 320 


Arg Val Ile Asp Ser Gln Ala Glu Lys Leu Lys Glu Leu Asp Lys Glu 
                325                 330                 335     


Ile Arg Pro Phe Arg Gln Asn Trp Glu Glu Ala Asp Ser Met Lys Ser 
            340                 345                 350         


Ser Val Glu Ser Leu Gln Asn Arg Val Thr Glu Leu Glu Ser Val Asp 
        355                 360                 365             


Lys Ser Ala Gly Gln Val Ala Arg Asn Thr Gly Leu Leu Glu Ser Gln 
    370                 375                 380                 


Leu Ser Arg His Asp Gln Met Leu Ser Val His Asp Ile Arg Leu Ala 
385                 390                 395                 400 


Asp Met Asp Leu Arg Phe Gln Val Leu Glu Thr Ala Ser Tyr Asn Gly 
                405                 410                 415     


Val Leu Ile Trp Lys Ile Arg Asp Tyr Lys Arg Arg Lys Gln Glu Ala 
            420                 425                 430         


Val Met Gly Lys Thr Leu Ser Leu Tyr Ser Gln Pro Phe Tyr Thr Gly 
        435                 440                 445             


Tyr Phe Gly Tyr Lys Met Cys Ala Arg Val Tyr Leu Asn Gly Asp Gly 
    450                 455                 460                 


Met Gly Lys Gly Thr His Leu Ser Leu Phe Phe Val Ile Met Arg Gly 
465                 470                 475                 480 


Glu Tyr Asp Ala Leu Leu Pro Trp Pro Phe Lys Gln Lys Val Thr Leu 
                485                 490                 495     


Met Leu Met Asp Gln Gly Ser Ser Arg Arg His Leu Gly Asp Ala Phe 
            500                 505                 510         


Lys Pro Asp Pro Asn Ser Ser Ser Phe Lys Lys Pro Thr Gly Glu Met 
        515                 520                 525             


Asn Ile Ala Ser Gly Cys Pro Val Phe Val Ala Gln Thr Val Leu Glu 
    530                 535                 540                 


Asn Gly Thr Tyr Ile Lys Asp Asp Thr Ile Phe Ile Lys Val Ile Val 
545                 550                 555                 560 


Asp Thr Ser Asp Leu Pro Asp Pro 
                565             


<210>  473
<211>  1235
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (30)..(1073)

<400>  473
ctttcagtaa tcattcaacc aacgcttcc atg tct cta ctc tgt cgt aac aaa         53
                                Met Ser Leu Leu Cys Arg Asn Lys           
                                1               5                         

ggc tgt ggg cag cac ttt gac cct aat acc aac ctt cct gat tcc tgt        101
Gly Cys Gly Gln His Phe Asp Pro Asn Thr Asn Leu Pro Asp Ser Cys           
    10                  15                  20                            

tgc cat cac cct ggg gtc cca atc ttc cat gat gca ctt aag ggt tgg        149
Cys His His Pro Gly Val Pro Ile Phe His Asp Ala Leu Lys Gly Trp           
25                  30                  35                  40            

tcc tgc tgc cga aag cga act gta gat ttc tct gag ttc tta aac atc        197
Ser Cys Cys Arg Lys Arg Thr Val Asp Phe Ser Glu Phe Leu Asn Ile           
                45                  50                  55                

aag ggc tgt act atg gga cca cac tgt gct gag aag ctt cct gag gcc        245
Lys Gly Cys Thr Met Gly Pro His Cys Ala Glu Lys Leu Pro Glu Ala           
            60                  65                  70                    

cct caa cct gaa ggc cct gct aca agc agt tca ctt cag gag caa aaa        293
Pro Gln Pro Glu Gly Pro Ala Thr Ser Ser Ser Leu Gln Glu Gln Lys           
        75                  80                  85                        

cct ctg aat gtg att cca aag tca gca gag acc ttg cgc cgg gag agg        341
Pro Leu Asn Val Ile Pro Lys Ser Ala Glu Thr Leu Arg Arg Glu Arg           
    90                  95                  100                           

ccc aag tca gag ttg cct ctg aag ctg ctg ccg cta aat ata tcc caa        389
Pro Lys Ser Glu Leu Pro Leu Lys Leu Leu Pro Leu Asn Ile Ser Gln           
105                 110                 115                 120           

gcc ctg gaa atg gca ttg gaa cag aag gaa tta gac cag gaa cct ggg        437
Ala Leu Glu Met Ala Leu Glu Gln Lys Glu Leu Asp Gln Glu Pro Gly           
                125                 130                 135               

gca gga ctt gac agt ctg atc cgg act ggt tcc agc tgc cag aac cca        485
Ala Gly Leu Asp Ser Leu Ile Arg Thr Gly Ser Ser Cys Gln Asn Pro           
            140                 145                 150                   

gga tgt gat gct gtt tac caa ggc cct gag agt gat gct act cca tgt        533
Gly Cys Asp Ala Val Tyr Gln Gly Pro Glu Ser Asp Ala Thr Pro Cys           
        155                 160                 165                       

acc tac cac cca gga gca ccc cga ttc cat gag ggg atg aag tct tgg        581
Thr Tyr His Pro Gly Ala Pro Arg Phe His Glu Gly Met Lys Ser Trp           
    170                 175                 180                           

agc tgt tgt ggc atc cag acc ctg gat ttt ggg gca ttt ttg gca caa        629
Ser Cys Cys Gly Ile Gln Thr Leu Asp Phe Gly Ala Phe Leu Ala Gln           
185                 190                 195                 200           

cca ggg tgc aga gtc ggt aga cat gac tgg ggg aag cag ctc cca gca        677
Pro Gly Cys Arg Val Gly Arg His Asp Trp Gly Lys Gln Leu Pro Ala           
                205                 210                 215               

tct tgc cgc cat gat tgg cac cag aca gat tcc tta gta gtg gtg act        725
Ser Cys Arg His Asp Trp His Gln Thr Asp Ser Leu Val Val Val Thr           
            220                 225                 230                   

gta tat ggc cag att cca ctt cct gcg ttt aac tgg gtg aag gcc agt        773
Val Tyr Gly Gln Ile Pro Leu Pro Ala Phe Asn Trp Val Lys Ala Ser           
        235                 240                 245                       

caa act gag ctt cat gtc cac att gtc ttt gat ggt aac cgt gtg ttc        821
Gln Thr Glu Leu His Val His Ile Val Phe Asp Gly Asn Arg Val Phe           
    250                 255                 260                           

caa gca cag atg aag ctc tgg ggg gtc ata aac gtg gag cag agc tct        869
Gln Ala Gln Met Lys Leu Trp Gly Val Ile Asn Val Glu Gln Ser Ser           
265                 270                 275                 280           

gtc ttc ttg atg cca tct cgg gtt gaa atc tcc ctg gtc aag gct gac        917
Val Phe Leu Met Pro Ser Arg Val Glu Ile Ser Leu Val Lys Ala Asp           
                285                 290                 295               

cca gga tcc tgg gcc cag ctg gag cac cct gat gca cta gct aag aag        965
Pro Gly Ser Trp Ala Gln Leu Glu His Pro Asp Ala Leu Ala Lys Lys           
            300                 305                 310                   

gct agg gca ggg gtt gtg tta gag atg gat gag gaa gaa tct gac gat       1013
Ala Arg Ala Gly Val Val Leu Glu Met Asp Glu Glu Glu Ser Asp Asp           
        315                 320                 325                       

tca gat gat gat ctg agc tgg aca gag gag gag gaa gag gag gaa gca       1061
Ser Asp Asp Asp Leu Ser Trp Thr Glu Glu Glu Glu Glu Glu Glu Ala           
    330                 335                 340                           

atg ggg gaa tag tgacaccaga cagttgatgt ctagatagga cctcaatgat           1113
Met Gly Glu                                                               
345                                                                       

tcccttagaa tcttagatac caggatattg ttggccatgt ggcatcattg agcagcagga     1173

ggctgaagga ggggagaaca aaattgtcca aaccatgctg tttttttccc ttaaataaat     1233

ct                                                                    1235


<210>  474
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  474

Met Ser Leu Leu Cys Arg Asn Lys Gly Cys Gly Gln His Phe Asp Pro 
1               5                   10                  15      


Asn Thr Asn Leu Pro Asp Ser Cys Cys His His Pro Gly Val Pro Ile 
            20                  25                  30          


Phe His Asp Ala Leu Lys Gly Trp Ser Cys Cys Arg Lys Arg Thr Val 
        35                  40                  45              


Asp Phe Ser Glu Phe Leu Asn Ile Lys Gly Cys Thr Met Gly Pro His 
    50                  55                  60                  


Cys Ala Glu Lys Leu Pro Glu Ala Pro Gln Pro Glu Gly Pro Ala Thr 
65                  70                  75                  80  


Ser Ser Ser Leu Gln Glu Gln Lys Pro Leu Asn Val Ile Pro Lys Ser 
                85                  90                  95      


Ala Glu Thr Leu Arg Arg Glu Arg Pro Lys Ser Glu Leu Pro Leu Lys 
            100                 105                 110         


Leu Leu Pro Leu Asn Ile Ser Gln Ala Leu Glu Met Ala Leu Glu Gln 
        115                 120                 125             


Lys Glu Leu Asp Gln Glu Pro Gly Ala Gly Leu Asp Ser Leu Ile Arg 
    130                 135                 140                 


Thr Gly Ser Ser Cys Gln Asn Pro Gly Cys Asp Ala Val Tyr Gln Gly 
145                 150                 155                 160 


Pro Glu Ser Asp Ala Thr Pro Cys Thr Tyr His Pro Gly Ala Pro Arg 
                165                 170                 175     


Phe His Glu Gly Met Lys Ser Trp Ser Cys Cys Gly Ile Gln Thr Leu 
            180                 185                 190         


Asp Phe Gly Ala Phe Leu Ala Gln Pro Gly Cys Arg Val Gly Arg His 
        195                 200                 205             


Asp Trp Gly Lys Gln Leu Pro Ala Ser Cys Arg His Asp Trp His Gln 
    210                 215                 220                 


Thr Asp Ser Leu Val Val Val Thr Val Tyr Gly Gln Ile Pro Leu Pro 
225                 230                 235                 240 


Ala Phe Asn Trp Val Lys Ala Ser Gln Thr Glu Leu His Val His Ile 
                245                 250                 255     


Val Phe Asp Gly Asn Arg Val Phe Gln Ala Gln Met Lys Leu Trp Gly 
            260                 265                 270         


Val Ile Asn Val Glu Gln Ser Ser Val Phe Leu Met Pro Ser Arg Val 
        275                 280                 285             


Glu Ile Ser Leu Val Lys Ala Asp Pro Gly Ser Trp Ala Gln Leu Glu 
    290                 295                 300                 


His Pro Asp Ala Leu Ala Lys Lys Ala Arg Ala Gly Val Val Leu Glu 
305                 310                 315                 320 


Met Asp Glu Glu Glu Ser Asp Asp Ser Asp Asp Asp Leu Ser Trp Thr 
                325                 330                 335     


Glu Glu Glu Glu Glu Glu Glu Ala Met Gly Glu 
            340                 345         


<210>  475
<211>  2055
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (282)..(1400)

<400>  475
gcagagcggg cggcggcggc ggcggcagcg gaggcggcgg ctccagccgg cgcggcgcga       60

ggctcggcgg tgggatccgg cgggcggtgc tagctccgcg ctccctgcct cgctcgctgc      120

cgggggcggt cggaaggcgc ggcgcgaagc ccgggtggcc cgagggcgcg actctagcct      180

tgtcacctca tcttgccccc ttggttttgg aagtcctgaa gagttggtct ggaggaggag      240

gaggacattg atgtgcttgg tgtgtggcca gtggtgaaga g atg gct gct cct gtc      296
                                              Met Ala Ala Pro Val         
                                              1               5           

ccg tgg gcc tgc tgt gct gtg ctt gcc gcc gcc gcc gca gtt gtc tac        344
Pro Trp Ala Cys Cys Ala Val Leu Ala Ala Ala Ala Ala Val Val Tyr           
                10                  15                  20                

gcc cag aga cac agt cca cag gag gca ccc cat gtg cag tac gag cgc        392
Ala Gln Arg His Ser Pro Gln Glu Ala Pro His Val Gln Tyr Glu Arg           
            25                  30                  35                    

ctg ggc tct gac gtg aca ctg cca tgt ggg aca gca aac tgg gat gct        440
Leu Gly Ser Asp Val Thr Leu Pro Cys Gly Thr Ala Asn Trp Asp Ala           
        40                  45                  50                        

gcg gtg acg tgg cgg gta aat ggg aca gac ctg gcc cct gac ctg ctc        488
Ala Val Thr Trp Arg Val Asn Gly Thr Asp Leu Ala Pro Asp Leu Leu           
    55                  60                  65                            

aac ggc tct cag ctg gtg ctc cat ggc ctg gaa ctg ggc cac agt ggc        536
Asn Gly Ser Gln Leu Val Leu His Gly Leu Glu Leu Gly His Ser Gly           
70                  75                  80                  85            

ctc tac gcc tgc ttc cac cgt gac tcc tgg cac ctg cgc cac caa gtc        584
Leu Tyr Ala Cys Phe His Arg Asp Ser Trp His Leu Arg His Gln Val           
                90                  95                  100               

ctg ctg cat gtg ggc ttg ccg ccg cgg gag cct gtg ctc agc tgc cgc        632
Leu Leu His Val Gly Leu Pro Pro Arg Glu Pro Val Leu Ser Cys Arg           
            105                 110                 115                   

tcc aac act tac ccc aag ggc ttc tac tgc agc tgg cat ctg ccc acc        680
Ser Asn Thr Tyr Pro Lys Gly Phe Tyr Cys Ser Trp His Leu Pro Thr           
        120                 125                 130                       

ccc acc tac att ccc aac acc ttc aat gtg act gtg ctg cat ggc tcc        728
Pro Thr Tyr Ile Pro Asn Thr Phe Asn Val Thr Val Leu His Gly Ser           
    135                 140                 145                           

aaa att atg gtc tgt gag aag gac cca gcc ctc aag aac cgc tgc cac        776
Lys Ile Met Val Cys Glu Lys Asp Pro Ala Leu Lys Asn Arg Cys His           
150                 155                 160                 165           

att cgc tac atg cac ctg ttc tcc acc atc aag tac aag gtc tcc ata        824
Ile Arg Tyr Met His Leu Phe Ser Thr Ile Lys Tyr Lys Val Ser Ile           
                170                 175                 180               

agt gtc agc aat gcc ctg ggc cac aat gcc aca gct atc acc ttt gac        872
Ser Val Ser Asn Ala Leu Gly His Asn Ala Thr Ala Ile Thr Phe Asp           
            185                 190                 195                   

gag ttc acc att gtg aag cct gat cct cca gaa aat gtg gta gcc cgg        920
Glu Phe Thr Ile Val Lys Pro Asp Pro Pro Glu Asn Val Val Ala Arg           
        200                 205                 210                       

cca gtg ccc agc aac cct cgc cgg ctg gag gtg acg tgg cag acc ccc        968
Pro Val Pro Ser Asn Pro Arg Arg Leu Glu Val Thr Trp Gln Thr Pro           
    215                 220                 225                           

tcg acc tgg cct gac cct gag tct ttt cct ctc aag ttc ttt ctg cgc       1016
Ser Thr Trp Pro Asp Pro Glu Ser Phe Pro Leu Lys Phe Phe Leu Arg           
230                 235                 240                 245           

tac cga ccc ctc atc ctg gac cag tgg cag cat gtg gag ctg tcc gac       1064
Tyr Arg Pro Leu Ile Leu Asp Gln Trp Gln His Val Glu Leu Ser Asp           
                250                 255                 260               

ggc aca gca cac acc atc aca gat gcc tac gcc ggg aag gag tac att       1112
Gly Thr Ala His Thr Ile Thr Asp Ala Tyr Ala Gly Lys Glu Tyr Ile           
            265                 270                 275                   

atc cag gtg gca gcc aag gac aat gag att ggg aca tgg agt gac tgg       1160
Ile Gln Val Ala Ala Lys Asp Asn Glu Ile Gly Thr Trp Ser Asp Trp           
        280                 285                 290                       

agc gta gcc gcc cac gct acg ccc tgg act gag gaa ccg cga cac ctc       1208
Ser Val Ala Ala His Ala Thr Pro Trp Thr Glu Glu Pro Arg His Leu           
    295                 300                 305                           

acc acg gag gcc cag gct gcg gag acc acg acc agc acc acc agc tcc       1256
Thr Thr Glu Ala Gln Ala Ala Glu Thr Thr Thr Ser Thr Thr Ser Ser           
310                 315                 320                 325           

ctg gca ccc cca cct acc acg aag atc tgt gac cct ggg gag ctg ggc       1304
Leu Ala Pro Pro Pro Thr Thr Lys Ile Cys Asp Pro Gly Glu Leu Gly           
                330                 335                 340               

agc ggc ggg gga ccc tcg gca ccc ttc ttg gtc agc gtc ccc atc act       1352
Ser Gly Gly Gly Pro Ser Ala Pro Phe Leu Val Ser Val Pro Ile Thr           
            345                 350                 355                   

ctg gcc ctg gct gcc gct gcc gcc act gcc agc agt ctc ttg atc tga       1400
Leu Ala Leu Ala Ala Ala Ala Ala Thr Ala Ser Ser Leu Leu Ile               
        360                 365                 370                       

gcccggcacc ccatgaggac atgcagagca cctgcagagg agcaggaggc cggagctgag     1460

cctgcagacc ccggtttcta ttttgcacac gggcaggagg accttttgca ttctcttcag     1520

acacaatttg tggagacccc ggcgggcccg ggcctgccgc cccccagccc tgccgcacca     1580

agctggccct ccttcctccc tcaggggagg tgggccatgc agctaaccca cccaccaaag     1640

accccctcac cctggcccct tgggctggac cctccaatgc cagcgactcc caggagccct     1700

tgggggacgt gaggggagcc tctcacatcc gatttctcct cctgccccag cctcctgtct     1760

atcccagggt ctctgttgcc accatcagat tataagctcc tgatgctggg ggggcccagc     1820

catccccctc cccccagcac ccacaatttt cagtcccctc ccctctgccc tgttttgtat     1880

acccctcccc tgaccctgct cctatcccac agtatttaat gccctgtcag tcccttctag     1940

tctgactcaa tggtaacttg ctgtatttga attttttata gatgtatata cagggtgggg     2000

ggagtgggcg gttctcatta aacgtcacca tttcatgaaa aaaaaaaaaa aaaaa          2055


<210>  476
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  476

Met Ala Ala Pro Val Pro Trp Ala Cys Cys Ala Val Leu Ala Ala Ala 
1               5                   10                  15      


Ala Ala Val Val Tyr Ala Gln Arg His Ser Pro Gln Glu Ala Pro His 
            20                  25                  30          


Val Gln Tyr Glu Arg Leu Gly Ser Asp Val Thr Leu Pro Cys Gly Thr 
        35                  40                  45              


Ala Asn Trp Asp Ala Ala Val Thr Trp Arg Val Asn Gly Thr Asp Leu 
    50                  55                  60                  


Ala Pro Asp Leu Leu Asn Gly Ser Gln Leu Val Leu His Gly Leu Glu 
65                  70                  75                  80  


Leu Gly His Ser Gly Leu Tyr Ala Cys Phe His Arg Asp Ser Trp His 
                85                  90                  95      


Leu Arg His Gln Val Leu Leu His Val Gly Leu Pro Pro Arg Glu Pro 
            100                 105                 110         


Val Leu Ser Cys Arg Ser Asn Thr Tyr Pro Lys Gly Phe Tyr Cys Ser 
        115                 120                 125             


Trp His Leu Pro Thr Pro Thr Tyr Ile Pro Asn Thr Phe Asn Val Thr 
    130                 135                 140                 


Val Leu His Gly Ser Lys Ile Met Val Cys Glu Lys Asp Pro Ala Leu 
145                 150                 155                 160 


Lys Asn Arg Cys His Ile Arg Tyr Met His Leu Phe Ser Thr Ile Lys 
                165                 170                 175     


Tyr Lys Val Ser Ile Ser Val Ser Asn Ala Leu Gly His Asn Ala Thr 
            180                 185                 190         


Ala Ile Thr Phe Asp Glu Phe Thr Ile Val Lys Pro Asp Pro Pro Glu 
        195                 200                 205             


Asn Val Val Ala Arg Pro Val Pro Ser Asn Pro Arg Arg Leu Glu Val 
    210                 215                 220                 


Thr Trp Gln Thr Pro Ser Thr Trp Pro Asp Pro Glu Ser Phe Pro Leu 
225                 230                 235                 240 


Lys Phe Phe Leu Arg Tyr Arg Pro Leu Ile Leu Asp Gln Trp Gln His 
                245                 250                 255     


Val Glu Leu Ser Asp Gly Thr Ala His Thr Ile Thr Asp Ala Tyr Ala 
            260                 265                 270         


Gly Lys Glu Tyr Ile Ile Gln Val Ala Ala Lys Asp Asn Glu Ile Gly 
        275                 280                 285             


Thr Trp Ser Asp Trp Ser Val Ala Ala His Ala Thr Pro Trp Thr Glu 
    290                 295                 300                 


Glu Pro Arg His Leu Thr Thr Glu Ala Gln Ala Ala Glu Thr Thr Thr 
305                 310                 315                 320 


Ser Thr Thr Ser Ser Leu Ala Pro Pro Pro Thr Thr Lys Ile Cys Asp 
                325                 330                 335     


Pro Gly Glu Leu Gly Ser Gly Gly Gly Pro Ser Ala Pro Phe Leu Val 
            340                 345                 350         


Ser Val Pro Ile Thr Leu Ala Leu Ala Ala Ala Ala Ala Thr Ala Ser 
        355                 360                 365             


Ser Leu Leu Ile 
    370         


<210>  477
<211>  2542
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (29)..(1705)

<400>  477
ggccacgttc agcggacacg ggagcaag atg gcg att ccg ggc agg cag tat          52
                               Met Ala Ile Pro Gly Arg Gln Tyr            
                               1               5                          

ggg ctt att ttg cca aag aaa aca cag cag ttg cac cct gtt ttg caa        100
Gly Leu Ile Leu Pro Lys Lys Thr Gln Gln Leu His Pro Val Leu Gln           
    10                  15                  20                            

aaa cca tca gtg ttt ggg aat gat tct gat gat gat gat gag acc tct        148
Lys Pro Ser Val Phe Gly Asn Asp Ser Asp Asp Asp Asp Glu Thr Ser           
25                  30                  35                  40            

gtg agt gaa agc ctt cag agg gaa gct gct aag aag cag gcc atg aaa        196
Val Ser Glu Ser Leu Gln Arg Glu Ala Ala Lys Lys Gln Ala Met Lys           
                45                  50                  55                

cag acc aaa ctg gaa atc cag aag gcc ctt gca gaa gat gct act gtg        244
Gln Thr Lys Leu Glu Ile Gln Lys Ala Leu Ala Glu Asp Ala Thr Val           
            60                  65                  70                    

tat gaa tat gac agt att tat gat gaa atg cag aaa aaa aag gag gaa        292
Tyr Glu Tyr Asp Ser Ile Tyr Asp Glu Met Gln Lys Lys Lys Glu Glu           
        75                  80                  85                        

aat aat ccc aaa ttg ctt ttg ggg aaa gac aga aag ccc aag tat att        340
Asn Asn Pro Lys Leu Leu Leu Gly Lys Asp Arg Lys Pro Lys Tyr Ile           
    90                  95                  100                           

cac aac ttg cta aaa gca gtt gag atc aga aaa aag gaa cag gaa aaa        388
His Asn Leu Leu Lys Ala Val Glu Ile Arg Lys Lys Glu Gln Glu Lys           
105                 110                 115                 120           

aga atg gaa aag aaa ata cag aga gaa cga gaa atg gaa aag ggg gag        436
Arg Met Glu Lys Lys Ile Gln Arg Glu Arg Glu Met Glu Lys Gly Glu           
                125                 130                 135               

ttt gat gat aaa gaa gca ttt gtg aca tct gca tat aag aaa aaa ctg        484
Phe Asp Asp Lys Glu Ala Phe Val Thr Ser Ala Tyr Lys Lys Lys Leu           
            140                 145                 150                   

caa gag aga gct gaa gaa gaa gaa aga gaa aag agg gct gct gca ctg        532
Gln Glu Arg Ala Glu Glu Glu Glu Arg Glu Lys Arg Ala Ala Ala Leu           
        155                 160                 165                       

gaa gca tgt ttg gat gta acc aag cag aaa gat ctc agt gga ttt tat        580
Glu Ala Cys Leu Asp Val Thr Lys Gln Lys Asp Leu Ser Gly Phe Tyr           
    170                 175                 180                           

agg cac cta tta aat caa gca gtt ggt gaa gag gaa gta cct aaa tgc        628
Arg His Leu Leu Asn Gln Ala Val Gly Glu Glu Glu Val Pro Lys Cys           
185                 190                 195                 200           

agc ttt cgt gaa gcc aga tct ggt ata aag gaa gaa aaa tca agg ggc        676
Ser Phe Arg Glu Ala Arg Ser Gly Ile Lys Glu Glu Lys Ser Arg Gly           
                205                 210                 215               

ttc tcc aat gaa gta agt tca aaa aac aga ata cca caa gag aaa tgc        724
Phe Ser Asn Glu Val Ser Ser Lys Asn Arg Ile Pro Gln Glu Lys Cys           
            220                 225                 230                   

att ctt caa act gat gtg aaa gta gag gaa aac cca gat gca gac agt        772
Ile Leu Gln Thr Asp Val Lys Val Glu Glu Asn Pro Asp Ala Asp Ser           
        235                 240                 245                       

gac ttc gat gct aag agc agt gcg gat gat gaa ata gaa gaa act aga        820
Asp Phe Asp Ala Lys Ser Ser Ala Asp Asp Glu Ile Glu Glu Thr Arg           
    250                 255                 260                           

gtg aac tgc aga agg gaa aag gtc ata gag acc cct gag aat gac ttc        868
Val Asn Cys Arg Arg Glu Lys Val Ile Glu Thr Pro Glu Asn Asp Phe           
265                 270                 275                 280           

aag cac cac agg agt caa aac cac tct cgg tca cct agt gaa gaa aga        916
Lys His His Arg Ser Gln Asn His Ser Arg Ser Pro Ser Glu Glu Arg           
                285                 290                 295               

ggg cac agt acc agg cac cac acg aaa gga tca cga acg tcg aga gga        964
Gly His Ser Thr Arg His His Thr Lys Gly Ser Arg Thr Ser Arg Gly           
            300                 305                 310                   

cat gag aaa agg gaa gat cag cac cag cag aag caa tcc aga gac caa       1012
His Glu Lys Arg Glu Asp Gln His Gln Gln Lys Gln Ser Arg Asp Gln           
        315                 320                 325                       

gag aac cat tac act gac cgt gat tac cgg aaa gaa agg gat tct cat       1060
Glu Asn His Tyr Thr Asp Arg Asp Tyr Arg Lys Glu Arg Asp Ser His           
    330                 335                 340                           

agg cac aga gag gcc agt cat aga gat tcc cat tgg aag agg cat gaa       1108
Arg His Arg Glu Ala Ser His Arg Asp Ser His Trp Lys Arg His Glu           
345                 350                 355                 360           

cag gaa gat aaa cca agg gcg agg gac caa aga gaa aga agt gac aga       1156
Gln Glu Asp Lys Pro Arg Ala Arg Asp Gln Arg Glu Arg Ser Asp Arg           
                365                 370                 375               

gta tgg aaa agg gag aaa gat agg gag aaa tat tcc caa aga gaa caa       1204
Val Trp Lys Arg Glu Lys Asp Arg Glu Lys Tyr Ser Gln Arg Glu Gln           
            380                 385                 390                   

gaa aga gat aga caa caa aat gat cag aac cga ccc agt gag aaa gga       1252
Glu Arg Asp Arg Gln Gln Asn Asp Gln Asn Arg Pro Ser Glu Lys Gly           
        395                 400                 405                       

gag aag gaa gag aaa agc aaa gca aag gaa gag cat atg aaa gta agg       1300
Glu Lys Glu Glu Lys Ser Lys Ala Lys Glu Glu His Met Lys Val Arg           
    410                 415                 420                           

aag gaa aga tat gaa aat aat gat aaa tac aga gat aga gaa aaa cga       1348
Lys Glu Arg Tyr Glu Asn Asn Asp Lys Tyr Arg Asp Arg Glu Lys Arg           
425                 430                 435                 440           

gag gta ggt gtt cag tct tca gaa aga aat caa gac aga aag gaa agc       1396
Glu Val Gly Val Gln Ser Ser Glu Arg Asn Gln Asp Arg Lys Glu Ser           
                445                 450                 455               

agc cca aat tct agg gca aag gat aaa ttt ctt gac caa gaa aga tcc       1444
Ser Pro Asn Ser Arg Ala Lys Asp Lys Phe Leu Asp Gln Glu Arg Ser           
            460                 465                 470                   

aac aaa atg aga aac atg gca aag gac aaa gaa aga aac caa gag aaa       1492
Asn Lys Met Arg Asn Met Ala Lys Asp Lys Glu Arg Asn Gln Glu Lys           
        475                 480                 485                       

ccc tct aat tct gaa tca tca ctg gga gca aaa cac aga ctc aca gag       1540
Pro Ser Asn Ser Glu Ser Ser Leu Gly Ala Lys His Arg Leu Thr Glu           
    490                 495                 500                           

gaa ggg caa gag aag ggt aaa gaa caa gag aga cca cct gag gca gtg       1588
Glu Gly Gln Glu Lys Gly Lys Glu Gln Glu Arg Pro Pro Glu Ala Val           
505                 510                 515                 520           

agc aag ttt gca aag cgg aac aat gaa gaa act gta atg tca gct aga       1636
Ser Lys Phe Ala Lys Arg Asn Asn Glu Glu Thr Val Met Ser Ala Arg           
                525                 530                 535               

gac agg tac ttg gcc agg cag atg gcg cgg gtt aat gca aag acc tat       1684
Asp Arg Tyr Leu Ala Arg Gln Met Ala Arg Val Asn Ala Lys Thr Tyr           
            540                 545                 550                   

att gag aaa gaa gat gat tga tggctacccc aagagaaaga tttaaggaag          1735
Ile Glu Lys Glu Asp Asp                                                   
        555                                                               

cacagaaaac tgtaattcct ggaacctgct gcgtaaaacc ataaaggagt gtgttaccag     1795

tagtttggag ggcattttta aatttatttt caaaatttta agttaaaagt cagtcttaca     1855

gcttggatgt ttggatgtgg atgtttggct gaatttatat atagtgtgta ctcatcaata     1915

ccacattctt tgttgtattc aagaaccgtt aagagtgtgc taattccctg taggtacata     1975

atgaggaaaa tttgctccac tacaaccatt aaaaaataat tttggccaga tacggtagct     2035

cgtgcctgta ataccaacat tttgggaggc caaggcagaa ggatattgag gctaggcatt     2095

caagaccagc ctaggcagga taataagacc ttgtctctat ttaaaaaaca aaaagcctag     2155

catggtagtc catgcctgta gtcccagctg ttcgagaggc tgaggcaaga agatcacttg     2215

agcctaggaa tttgatgtta cagtgaggta tgatcatgcc actgcactcc aacctgggca     2275

acagaatgag accctgtctc taaaaaattt tttttaaata aataatttaa ctcttctaat     2335

aatgttttgt tgcaggaaat gtatttcaga taaaatatgg atttgaaaaa cagaaaatat     2395

actttatgtt ctgaaatttg tatttaagta taaaatgtga atcatcttgt ctaaatagct     2455

tacagcatag ttggcttaaa tgaaaataaa atgatatgct tataaaaaaa aaaaaaaaaa     2515

aaaaaaaaaa aaaaaaaaaa aaaaaaa                                         2542


<210>  478
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  478

Met Ala Ile Pro Gly Arg Gln Tyr Gly Leu Ile Leu Pro Lys Lys Thr 
1               5                   10                  15      


Gln Gln Leu His Pro Val Leu Gln Lys Pro Ser Val Phe Gly Asn Asp 
            20                  25                  30          


Ser Asp Asp Asp Asp Glu Thr Ser Val Ser Glu Ser Leu Gln Arg Glu 
        35                  40                  45              


Ala Ala Lys Lys Gln Ala Met Lys Gln Thr Lys Leu Glu Ile Gln Lys 
    50                  55                  60                  


Ala Leu Ala Glu Asp Ala Thr Val Tyr Glu Tyr Asp Ser Ile Tyr Asp 
65                  70                  75                  80  


Glu Met Gln Lys Lys Lys Glu Glu Asn Asn Pro Lys Leu Leu Leu Gly 
                85                  90                  95      


Lys Asp Arg Lys Pro Lys Tyr Ile His Asn Leu Leu Lys Ala Val Glu 
            100                 105                 110         


Ile Arg Lys Lys Glu Gln Glu Lys Arg Met Glu Lys Lys Ile Gln Arg 
        115                 120                 125             


Glu Arg Glu Met Glu Lys Gly Glu Phe Asp Asp Lys Glu Ala Phe Val 
    130                 135                 140                 


Thr Ser Ala Tyr Lys Lys Lys Leu Gln Glu Arg Ala Glu Glu Glu Glu 
145                 150                 155                 160 


Arg Glu Lys Arg Ala Ala Ala Leu Glu Ala Cys Leu Asp Val Thr Lys 
                165                 170                 175     


Gln Lys Asp Leu Ser Gly Phe Tyr Arg His Leu Leu Asn Gln Ala Val 
            180                 185                 190         


Gly Glu Glu Glu Val Pro Lys Cys Ser Phe Arg Glu Ala Arg Ser Gly 
        195                 200                 205             


Ile Lys Glu Glu Lys Ser Arg Gly Phe Ser Asn Glu Val Ser Ser Lys 
    210                 215                 220                 


Asn Arg Ile Pro Gln Glu Lys Cys Ile Leu Gln Thr Asp Val Lys Val 
225                 230                 235                 240 


Glu Glu Asn Pro Asp Ala Asp Ser Asp Phe Asp Ala Lys Ser Ser Ala 
                245                 250                 255     


Asp Asp Glu Ile Glu Glu Thr Arg Val Asn Cys Arg Arg Glu Lys Val 
            260                 265                 270         


Ile Glu Thr Pro Glu Asn Asp Phe Lys His His Arg Ser Gln Asn His 
        275                 280                 285             


Ser Arg Ser Pro Ser Glu Glu Arg Gly His Ser Thr Arg His His Thr 
    290                 295                 300                 


Lys Gly Ser Arg Thr Ser Arg Gly His Glu Lys Arg Glu Asp Gln His 
305                 310                 315                 320 


Gln Gln Lys Gln Ser Arg Asp Gln Glu Asn His Tyr Thr Asp Arg Asp 
                325                 330                 335     


Tyr Arg Lys Glu Arg Asp Ser His Arg His Arg Glu Ala Ser His Arg 
            340                 345                 350         


Asp Ser His Trp Lys Arg His Glu Gln Glu Asp Lys Pro Arg Ala Arg 
        355                 360                 365             


Asp Gln Arg Glu Arg Ser Asp Arg Val Trp Lys Arg Glu Lys Asp Arg 
    370                 375                 380                 


Glu Lys Tyr Ser Gln Arg Glu Gln Glu Arg Asp Arg Gln Gln Asn Asp 
385                 390                 395                 400 


Gln Asn Arg Pro Ser Glu Lys Gly Glu Lys Glu Glu Lys Ser Lys Ala 
                405                 410                 415     


Lys Glu Glu His Met Lys Val Arg Lys Glu Arg Tyr Glu Asn Asn Asp 
            420                 425                 430         


Lys Tyr Arg Asp Arg Glu Lys Arg Glu Val Gly Val Gln Ser Ser Glu 
        435                 440                 445             


Arg Asn Gln Asp Arg Lys Glu Ser Ser Pro Asn Ser Arg Ala Lys Asp 
    450                 455                 460                 


Lys Phe Leu Asp Gln Glu Arg Ser Asn Lys Met Arg Asn Met Ala Lys 
465                 470                 475                 480 


Asp Lys Glu Arg Asn Gln Glu Lys Pro Ser Asn Ser Glu Ser Ser Leu 
                485                 490                 495     


Gly Ala Lys His Arg Leu Thr Glu Glu Gly Gln Glu Lys Gly Lys Glu 
            500                 505                 510         


Gln Glu Arg Pro Pro Glu Ala Val Ser Lys Phe Ala Lys Arg Asn Asn 
        515                 520                 525             


Glu Glu Thr Val Met Ser Ala Arg Asp Arg Tyr Leu Ala Arg Gln Met 
    530                 535                 540                 


Ala Arg Val Asn Ala Lys Thr Tyr Ile Glu Lys Glu Asp Asp 
545                 550                 555             


<210>  479
<211>  725
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (12)..(584)

<400>  479
cttcgcagag c atg gcg gcg ggc gag ctt gag ggt ggc aaa ccc ctg agc        50
             Met Ala Ala Gly Glu Leu Glu Gly Gly Lys Pro Leu Ser          
             1               5                   10                       

ggg ctg ctg aat gcg ctg gcc cag gac act ttc cac ggg tac ccc ggc         98
Gly Leu Leu Asn Ala Leu Ala Gln Asp Thr Phe His Gly Tyr Pro Gly           
    15                  20                  25                            

atc aca gag gag ctg cta cgg agc cag cta tat cca gag gtg cca ccc        146
Ile Thr Glu Glu Leu Leu Arg Ser Gln Leu Tyr Pro Glu Val Pro Pro           
30                  35                  40                  45            

gag gag ttc cgc ccc ttt ctg gca aag atg agg ggg att ctt aag tct        194
Glu Glu Phe Arg Pro Phe Leu Ala Lys Met Arg Gly Ile Leu Lys Ser           
                50                  55                  60                

att gcg tct gca gac atg gat ttc aac cag ctg gag gca ttc ttg act        242
Ile Ala Ser Ala Asp Met Asp Phe Asn Gln Leu Glu Ala Phe Leu Thr           
            65                  70                  75                    

gct caa acc aaa aag caa ggt ggg atc aca tct gac caa gct gct gtc        290
Ala Gln Thr Lys Lys Gln Gly Gly Ile Thr Ser Asp Gln Ala Ala Val           
        80                  85                  90                        

att tcc aaa ttc tgg aag agc cac aag aca aaa atc cgt gag agc ctc        338
Ile Ser Lys Phe Trp Lys Ser His Lys Thr Lys Ile Arg Glu Ser Leu           
    95                  100                 105                           

atg aac cag agc cgc tgg aat agc ggg ctt cgg ggc ctg agc tgg aga        386
Met Asn Gln Ser Arg Trp Asn Ser Gly Leu Arg Gly Leu Ser Trp Arg           
110                 115                 120                 125           

gtt gat ggc aag tct cag tca agg cac tca gct caa ata cac aca cct        434
Val Asp Gly Lys Ser Gln Ser Arg His Ser Ala Gln Ile His Thr Pro           
                130                 135                 140               

gtt gcc att ata gag ctg gaa tta ggc aaa tat gga cag gaa tct gaa        482
Val Ala Ile Ile Glu Leu Glu Leu Gly Lys Tyr Gly Gln Glu Ser Glu           
            145                 150                 155                   

ttt ctg tgt ttg gaa ttt gat gag gtc aaa gtc aac caa att ctg aag        530
Phe Leu Cys Leu Glu Phe Asp Glu Val Lys Val Asn Gln Ile Leu Lys           
        160                 165                 170                       

acg ctg tca gag gta gaa gaa agt atc agc aca ctg atc agc cag cct        578
Thr Leu Ser Glu Val Glu Glu Ser Ile Ser Thr Leu Ile Ser Gln Pro           
    175                 180                 185                           

aac tga agatgatgta tgaaggagtt ggagttgttg aaaccaaggt gtccatgatc         634
Asn                                                                       
190                                                                       

cctccccact gaccttttct aagaaaattc ttgtgcccgc attggtatta aatcctcgca      694

ttcagtcttc ctgcctctaa aaaaaaaaaa a                                     725


<210>  480
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  480

Met Ala Ala Gly Glu Leu Glu Gly Gly Lys Pro Leu Ser Gly Leu Leu 
1               5                   10                  15      


Asn Ala Leu Ala Gln Asp Thr Phe His Gly Tyr Pro Gly Ile Thr Glu 
            20                  25                  30          


Glu Leu Leu Arg Ser Gln Leu Tyr Pro Glu Val Pro Pro Glu Glu Phe 
        35                  40                  45              


Arg Pro Phe Leu Ala Lys Met Arg Gly Ile Leu Lys Ser Ile Ala Ser 
    50                  55                  60                  


Ala Asp Met Asp Phe Asn Gln Leu Glu Ala Phe Leu Thr Ala Gln Thr 
65                  70                  75                  80  


Lys Lys Gln Gly Gly Ile Thr Ser Asp Gln Ala Ala Val Ile Ser Lys 
                85                  90                  95      


Phe Trp Lys Ser His Lys Thr Lys Ile Arg Glu Ser Leu Met Asn Gln 
            100                 105                 110         


Ser Arg Trp Asn Ser Gly Leu Arg Gly Leu Ser Trp Arg Val Asp Gly 
        115                 120                 125             


Lys Ser Gln Ser Arg His Ser Ala Gln Ile His Thr Pro Val Ala Ile 
    130                 135                 140                 


Ile Glu Leu Glu Leu Gly Lys Tyr Gly Gln Glu Ser Glu Phe Leu Cys 
145                 150                 155                 160 


Leu Glu Phe Asp Glu Val Lys Val Asn Gln Ile Leu Lys Thr Leu Ser 
                165                 170                 175     


Glu Val Glu Glu Ser Ile Ser Thr Leu Ile Ser Gln Pro Asn 
            180                 185                 190 


<210>  481
<211>  1955
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (430)..(1167)

<400>  481
agaggggcgg gacttctccg ggtcaaggcc aggtctcttc cctgctcggt gctatgttcc       60

tgttccacgg ggtggcgggt cctggaaggg agaagcccag acccagtgga cactgacatt      120

gtctctcgct gttcccagcc ttttccaggc gtgtgactta atccgtttcc acagccagac      180

cttttctccg tgagttcctc agccaggact gctgccatgc cggtgactgt tacccaccca      240

accgtcacga ccaccatgcg gtcccccacc gtcgtagggt cctctagggc cctgatccag      300

cccctgggcc tcctccgcct gctgcagctg gtgtccacct gcgtggcctt gtcactggtg      360

gccagcgtgg gcgcctggaa ggggcctatg ggtaactggt ccatgttcac ctagtgtttc      420

tgctttgcc atg acc ctg gtc atc ctc ctc gtg gag ctg ggc ggc tcc cag      471
          Met Thr Leu Val Ile Leu Leu Val Glu Leu Gly Gly Ser Gln         
          1               5                   10                          

gcc cgc ttc ccc ttg ttt tgg cgc aac ttc ccc atc acc ttt gcc tgc        519
Ala Arg Phe Pro Leu Phe Trp Arg Asn Phe Pro Ile Thr Phe Ala Cys           
15                  20                  25                  30            

tat gcg gcc ctc ttg tgc ctc tcg gcc tcc atc atc tac ccc acc acc        567
Tyr Ala Ala Leu Leu Cys Leu Ser Ala Ser Ile Ile Tyr Pro Thr Thr           
                35                  40                  45                

tac ttg cag ttc ctg tcc cac ggc cgt tcc cgc gac cac gcc atc gcc        615
Tyr Leu Gln Phe Leu Ser His Gly Arg Ser Arg Asp His Ala Ile Ala           
            50                  55                  60                    

gcc atc gtc ttc tct ggc atc gcc tgt gtg gct tat gcc acc gaa gta        663
Ala Ile Val Phe Ser Gly Ile Ala Cys Val Ala Tyr Ala Thr Glu Val           
        65                  70                  75                        

acc tgg act cgg gcc cgg ccc ggc gag atc act gac tac atg gcc tcc        711
Thr Trp Thr Arg Ala Arg Pro Gly Glu Ile Thr Asp Tyr Met Ala Ser           
    80                  85                  90                            

gag ctg ggg ctg ctg aag gtg ctg gag acc ttc gtg gcc tgc ctc atc        759
Glu Leu Gly Leu Leu Lys Val Leu Glu Thr Phe Val Ala Cys Leu Ile           
95                  100                 105                 110           

ttc gtg ttc atc aat agc ccc tac gtg tac cac aac cgg ccg gcc ctg        807
Phe Val Phe Ile Asn Ser Pro Tyr Val Tyr His Asn Arg Pro Ala Leu           
                115                 120                 125               

gag tgg tgc gtg gcg gtg tac gcc ctc tgc ttc gtc ctg gcg gcc ctc        855
Glu Trp Cys Val Ala Val Tyr Ala Leu Cys Phe Val Leu Ala Ala Leu           
            130                 135                 140                   

act gtc ctg ctg agc ctg ggg cac tgc acc aac atg ctg ccc atc cgc        903
Thr Val Leu Leu Ser Leu Gly His Cys Thr Asn Met Leu Pro Ile Arg           
        145                 150                 155                       

ttc ccc agt ttc ctg ttg ggg ctg gcc ttg ctg tcc gtc ctc ctc tat        951
Phe Pro Ser Phe Leu Leu Gly Leu Ala Leu Leu Ser Val Leu Leu Tyr           
    160                 165                 170                           

gcc act gcc ctt gtc ctc tgg ccc ctc tac cag ttc aac gag aag tat        999
Ala Thr Ala Leu Val Leu Trp Pro Leu Tyr Gln Phe Asn Glu Lys Tyr           
175                 180                 185                 190           

ggt gtc cag ccc tgg cag acg aga gat gtg agc tgc agc gac aga aac       1047
Gly Val Gln Pro Trp Gln Thr Arg Asp Val Ser Cys Ser Asp Arg Asn           
                195                 200                 205               

ccc tac ctt gtg tgt atc tgg gac cgc cga ctg gct gtg acc aac ctg       1095
Pro Tyr Leu Val Cys Ile Trp Asp Arg Arg Leu Ala Val Thr Asn Leu           
            210                 215                 220                   

acg gcc gtc aac ttg ctg gcc tat gtg ggc gac ctg gtg tac tct gcc       1143
Thr Ala Val Asn Leu Leu Ala Tyr Val Gly Asp Leu Val Tyr Ser Ala           
        225                 230                 235                       

cac ctg gtt ttt gtc aag gtc taa gactcccaaa gggccccgtt tgcctctcca      1197
His Leu Val Phe Val Lys Val                                               
    240                 245                                               

acctcttcat cctgcccccc ctgagttttc tttattgagt attcatttcc tgtgttttcc     1257

tcttccctat ctcccctcct ccccttttct ttccttccca attcatcgca ctttcccagt     1317

tctctgatgt atgttcttcc ctttcctctg ctgtttcctt cttgttttgt tctgttgccc     1377

acaacctgtt ttcacccgtt tctctttttc cactctctct tttgtttctt tcctctcaat     1437

tcttttctag gtttcctgtt ggttttctta tctgcctatt tcccgaccat cttctcctat     1497

ttcctgggga gccctgaggc ttttcttctc ctgcccccac gcacctccag cggtgatgag     1557

ctccacaccc ccacacccat tgcagctgtg gcgccacgtc ctcccaaggg gccttctgcc     1617

cgcccccgcc ctagccctag ctgtgcctta gtcagtgtgt acttgtgtgt gtttggggga     1677

gtgggaattg ggcccccttt ctcccagtgg aggaaggtgt gctgtgcacc tcccctttaa     1737

attaaaaaaa atgtatgtat ctctggaggt caataatttc cagtgagcgg gaggcttcaa     1797

gcgcagaccc tgggtcccta gacctcgcct agcactctgc cttgccagag attggctcca     1857

gaatttgtgc cagacttaca gaaaacccac tgcctagagg ccatcttaaa ggaagcaatg     1917

gatggatccc tttcatccca actgttcttc gcggtatc                             1955


<210>  482
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  482

Met Thr Leu Val Ile Leu Leu Val Glu Leu Gly Gly Ser Gln Ala Arg 
1               5                   10                  15      


Phe Pro Leu Phe Trp Arg Asn Phe Pro Ile Thr Phe Ala Cys Tyr Ala 
            20                  25                  30          


Ala Leu Leu Cys Leu Ser Ala Ser Ile Ile Tyr Pro Thr Thr Tyr Leu 
        35                  40                  45              


Gln Phe Leu Ser His Gly Arg Ser Arg Asp His Ala Ile Ala Ala Ile 
    50                  55                  60                  


Val Phe Ser Gly Ile Ala Cys Val Ala Tyr Ala Thr Glu Val Thr Trp 
65                  70                  75                  80  


Thr Arg Ala Arg Pro Gly Glu Ile Thr Asp Tyr Met Ala Ser Glu Leu 
                85                  90                  95      


Gly Leu Leu Lys Val Leu Glu Thr Phe Val Ala Cys Leu Ile Phe Val 
            100                 105                 110         


Phe Ile Asn Ser Pro Tyr Val Tyr His Asn Arg Pro Ala Leu Glu Trp 
        115                 120                 125             


Cys Val Ala Val Tyr Ala Leu Cys Phe Val Leu Ala Ala Leu Thr Val 
    130                 135                 140                 


Leu Leu Ser Leu Gly His Cys Thr Asn Met Leu Pro Ile Arg Phe Pro 
145                 150                 155                 160 


Ser Phe Leu Leu Gly Leu Ala Leu Leu Ser Val Leu Leu Tyr Ala Thr 
                165                 170                 175     


Ala Leu Val Leu Trp Pro Leu Tyr Gln Phe Asn Glu Lys Tyr Gly Val 
            180                 185                 190         


Gln Pro Trp Gln Thr Arg Asp Val Ser Cys Ser Asp Arg Asn Pro Tyr 
        195                 200                 205             


Leu Val Cys Ile Trp Asp Arg Arg Leu Ala Val Thr Asn Leu Thr Ala 
    210                 215                 220                 


Val Asn Leu Leu Ala Tyr Val Gly Asp Leu Val Tyr Ser Ala His Leu 
225                 230                 235                 240 


Val Phe Val Lys Val 
                245 


<210>  483
<211>  5508
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (447)..(3155)

<400>  483
agtggcagaa gagggctagg ctgagaggga agccaggact gtaggagagg gaggcagccc       60

gtcctcctca cgaacctgca aggatgcggc aggggcctgg gggcatgggg aggtactaac      120

cccccggagc ccccgattgg ggcttgcaga cctggcccgt gggcggattt tctgcctagc      180

gcagccgaga agcagaggtg ccaggaaaac caagagaggg gcgctggggg tgcccatccc      240

cagagtcggt ccctctgcga accgaggaag aaaagaggag ggagtcagcg agtggtcaga      300

agggaaaacc tgacaccaga ctggctccgg agcgtccggg agactggggc gctccgcgcc      360

atcgtcttca atgcttctct gaacagcctt taggaagagt gcgagagaaa gagagagagc      420

gcgcgccagg gagaggagaa aagaag atg agg att att tcc aga cag att gtc       473
                             Met Arg Ile Ile Ser Arg Gln Ile Val          
                             1               5                            

ttg tta ttt tct gga ttt tgg gga ctc gcc atg gga gcc ttt ccg agc        521
Leu Leu Phe Ser Gly Phe Trp Gly Leu Ala Met Gly Ala Phe Pro Ser           
10                  15                  20                  25            

agc gtg caa ata ggt ggt ctc ttc atc cga aac aca gat cag gaa tac        569
Ser Val Gln Ile Gly Gly Leu Phe Ile Arg Asn Thr Asp Gln Glu Tyr           
                30                  35                  40                

act gct ttt cga tta gca att ttt ctt cat aac acc agc ccc aat gcg        617
Thr Ala Phe Arg Leu Ala Ile Phe Leu His Asn Thr Ser Pro Asn Ala           
            45                  50                  55                    

tcg gaa gct cct ttt aat ttg gta cct cat gtg gac aac att gag aca        665
Ser Glu Ala Pro Phe Asn Leu Val Pro His Val Asp Asn Ile Glu Thr           
        60                  65                  70                        

gcc aac agt ttt gct gta aca aac gcc ttc tgt tcc cag tat tct aga        713
Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln Tyr Ser Arg           
    75                  80                  85                            

gga gta ttt gcc att ttt gga ctc tat gat aag agg tcg gta cat acc        761
Gly Val Phe Ala Ile Phe Gly Leu Tyr Asp Lys Arg Ser Val His Thr           
90                  95                  100                 105           

ttg acc tca ttc tgc agc gcc tta cat atc tcc ctc atc aca cca agt        809
Leu Thr Ser Phe Cys Ser Ala Leu His Ile Ser Leu Ile Thr Pro Ser           
                110                 115                 120               

ttc cct act gag ggg gag agc cag ttt gtg ctg caa cta aga cct tcg        857
Phe Pro Thr Glu Gly Glu Ser Gln Phe Val Leu Gln Leu Arg Pro Ser           
            125                 130                 135                   

tta cga gga gca ctc ttg agt ttg ctg gat cac tac gaa tgg aac tgt        905
Leu Arg Gly Ala Leu Leu Ser Leu Leu Asp His Tyr Glu Trp Asn Cys           
        140                 145                 150                       

ttt gtc ttc ctg tat gac aca gac agg gga tac tcg ata ctc caa gct        953
Phe Val Phe Leu Tyr Asp Thr Asp Arg Gly Tyr Ser Ile Leu Gln Ala           
    155                 160                 165                           

att atg gaa aaa gca gga caa aat ggt tgg cat gtc agc gct ata tgt       1001
Ile Met Glu Lys Ala Gly Gln Asn Gly Trp His Val Ser Ala Ile Cys           
170                 175                 180                 185           

gtg gaa aat ttt aat gat gtc agc tat agg caa ctt cta gaa gaa ctt       1049
Val Glu Asn Phe Asn Asp Val Ser Tyr Arg Gln Leu Leu Glu Glu Leu           
                190                 195                 200               

gac aga aga caa gag aag aag ttt gta ata gac tgt gag ata gag aga       1097
Asp Arg Arg Gln Glu Lys Lys Phe Val Ile Asp Cys Glu Ile Glu Arg           
            205                 210                 215                   

ctt caa aac ata tta gaa cag att gta agt gtt gga aag cat gtt aaa       1145
Leu Gln Asn Ile Leu Glu Gln Ile Val Ser Val Gly Lys His Val Lys           
        220                 225                 230                       

ggc tac cat tat atc att gca aac ttg gga ttc aag gat att tct ctt       1193
Gly Tyr His Tyr Ile Ile Ala Asn Leu Gly Phe Lys Asp Ile Ser Leu           
    235                 240                 245                           

gag agg ttt ata cat ggt gga gcc aat gtt act gga ttc cag ttg gtg       1241
Glu Arg Phe Ile His Gly Gly Ala Asn Val Thr Gly Phe Gln Leu Val           
250                 255                 260                 265           

gat ttt aat aca cct atg gta atc aaa cta atg gat cgc tgg aag aaa       1289
Asp Phe Asn Thr Pro Met Val Ile Lys Leu Met Asp Arg Trp Lys Lys           
                270                 275                 280               

cta gat cag aga gag tat cca gga tct gag act cct cca aag tac acc       1337
Leu Asp Gln Arg Glu Tyr Pro Gly Ser Glu Thr Pro Pro Lys Tyr Thr           
            285                 290                 295                   

tct gct ctg act tat gat gga gtc ctt gtg atg gct gaa act ttc cga       1385
Ser Ala Leu Thr Tyr Asp Gly Val Leu Val Met Ala Glu Thr Phe Arg           
        300                 305                 310                       

agt ctt agg agg cag aaa att gat atc tca agg aga gga aat gct ggg       1433
Ser Leu Arg Arg Gln Lys Ile Asp Ile Ser Arg Arg Gly Asn Ala Gly           
    315                 320                 325                           

gat tgt ctg gca aat cct gct gct cca tgg ggc cag gga att gac atg       1481
Asp Cys Leu Ala Asn Pro Ala Ala Pro Trp Gly Gln Gly Ile Asp Met           
330                 335                 340                 345           

gag agg aca ctc aaa cag gtt cga att caa ggg ctg aca ggg aat gtt       1529
Glu Arg Thr Leu Lys Gln Val Arg Ile Gln Gly Leu Thr Gly Asn Val           
                350                 355                 360               

cag ttt gac cac tat gga cgt aga gtc aat tac aca atg gat gtg ttt       1577
Gln Phe Asp His Tyr Gly Arg Arg Val Asn Tyr Thr Met Asp Val Phe           
            365                 370                 375                   

gag ctg aaa agc aca gga cct aga aag gtt ggt tac tgg aat gat atg       1625
Glu Leu Lys Ser Thr Gly Pro Arg Lys Val Gly Tyr Trp Asn Asp Met           
        380                 385                 390                       

gat aag tta gtc ttg att caa gat gta cca act ctt ggc aat gac aca       1673
Asp Lys Leu Val Leu Ile Gln Asp Val Pro Thr Leu Gly Asn Asp Thr           
    395                 400                 405                           

gct gct att gag aac aga aca gtg gtt gta acc aca att atg gaa tcc       1721
Ala Ala Ile Glu Asn Arg Thr Val Val Val Thr Thr Ile Met Glu Ser           
410                 415                 420                 425           

cca tat gtt atg tac aag aaa aat cat gaa atg ttt gaa gga aat gac       1769
Pro Tyr Val Met Tyr Lys Lys Asn His Glu Met Phe Glu Gly Asn Asp           
                430                 435                 440               

aag tat gaa gga tac tgt gta gat ttg gca tct gaa att gca aaa cat       1817
Lys Tyr Glu Gly Tyr Cys Val Asp Leu Ala Ser Glu Ile Ala Lys His           
            445                 450                 455                   

att ggt atc aag tat aaa att gcc att gtc cct gat gga aaa tat gga       1865
Ile Gly Ile Lys Tyr Lys Ile Ala Ile Val Pro Asp Gly Lys Tyr Gly           
        460                 465                 470                       

gca agg gat gca gac aca aaa atc tgg aat ggg atg gta gga gaa ctt       1913
Ala Arg Asp Ala Asp Thr Lys Ile Trp Asn Gly Met Val Gly Glu Leu           
    475                 480                 485                           

gtt tat ggg aaa gca gag att gct att gcc cct ctg aca atc act ttg       1961
Val Tyr Gly Lys Ala Glu Ile Ala Ile Ala Pro Leu Thr Ile Thr Leu           
490                 495                 500                 505           

gta cga gag gag gtc att gac ttt tct aag ccc ttc atg agt ttg ggc       2009
Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met Ser Leu Gly           
                510                 515                 520               

ata tct atc atg atc aaa aag cct cag aaa tcc aaa cca gga gtg ttt       2057
Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val Phe           
            525                 530                 535                   

tcc ttc ttg gat cct ctg gcc tat gag att tgg atg tgc ata gtc ttt       2105
Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val Phe           
        540                 545                 550                       

gcc tac att ggt gtc agc gtg gtc tta ttc cta gtt agt aga ttt agt       2153
Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe Ser           
    555                 560                 565                           

cca tat gag tgg cac aca gaa gag cca gag gac gga aag gaa gga ccc       2201
Pro Tyr Glu Trp His Thr Glu Glu Pro Glu Asp Gly Lys Glu Gly Pro           
570                 575                 580                 585           

agc gac cag cct ccc aat gag ttt ggc atc ttt aac agc ctc tgg ttt       2249
Ser Asp Gln Pro Pro Asn Glu Phe Gly Ile Phe Asn Ser Leu Trp Phe           
                590                 595                 600               

tcc ctg ggt gct ttt atg cag caa gga tgt gac att tca ccc aga tcc       2297
Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser Pro Arg Ser           
            605                 610                 615                   

ctc tca ggt cga att gtt gga ggt gtt tgg tgg ttc ttt aca ctc atc       2345
Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe Thr Leu Ile           
        620                 625                 630                       

att ata tca tct tat act gct aac ctc gct gct ttc ctg acg gtt gag       2393
Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Thr Val Glu           
    635                 640                 645                           

cga atg gtc tct ccc ata gaa agt gca gaa gac ctg gcc aaa caa aca       2441
Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala Lys Gln Thr           
650                 655                 660                 665           

gaa att gcc tat gga aca ctg gat tca gga tca aca aaa gaa ttc ttc       2489
Glu Ile Ala Tyr Gly Thr Leu Asp Ser Gly Ser Thr Lys Glu Phe Phe           
                670                 675                 680               

aga aga tca aaa ata gca gtg tat gaa aag atg tgg acc tac atg cga       2537
Arg Arg Ser Lys Ile Ala Val Tyr Glu Lys Met Trp Thr Tyr Met Arg           
            685                 690                 695                   

tca gca gag cca tca gta ttc act agg act aca gct gag gga gta gct       2585
Ser Ala Glu Pro Ser Val Phe Thr Arg Thr Thr Ala Glu Gly Val Ala           
        700                 705                 710                       

cgt gtc cgc aaa tcc aag ggc aaa ttt gcc ttt ctc ctg gag tcc act       2633
Arg Val Arg Lys Ser Lys Gly Lys Phe Ala Phe Leu Leu Glu Ser Thr           
    715                 720                 725                           

atg aat gaa tac att gag cag cga aag cca tgt gac acg atg aaa gtg       2681
Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr Met Lys Val           
730                 735                 740                 745           

gga gga aat ctg gat tcc aaa ggc tat gga gta gca acg ccc aag ggt       2729
Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Val Ala Thr Pro Lys Gly           
                750                 755                 760               

tcc tca tta gga act cct gta aac ctt gcc gtt ttg aaa ctc agt gag       2777
Ser Ser Leu Gly Thr Pro Val Asn Leu Ala Val Leu Lys Leu Ser Glu           
            765                 770                 775                   

gca ggc gtc tta gac aag ctg aaa aac aaa tgg tgg tac gat aaa ggt       2825
Ala Gly Val Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr Asp Lys Gly           
        780                 785                 790                       

gaa tgt gga ccc aag gac tct gga agc aag gac aag acg agt gcc ttg       2873
Glu Cys Gly Pro Lys Asp Ser Gly Ser Lys Asp Lys Thr Ser Ala Leu           
    795                 800                 805                           

agc ctg agc aat gta gca ggc gtc ttc tac att ctg gtt ggc ggc ttg       2921
Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Val Gly Gly Leu           
810                 815                 820                 825           

ggc ttg gca atg ctg gtg gct ttg ata gag ttc tgt tac aag tcc agg       2969
Gly Leu Ala Met Leu Val Ala Leu Ile Glu Phe Cys Tyr Lys Ser Arg           
                830                 835                 840               

gca gaa gcg aag aga atg aag ctg acc ttt tct gaa gcc ata aga aac       3017
Ala Glu Ala Lys Arg Met Lys Leu Thr Phe Ser Glu Ala Ile Arg Asn           
            845                 850                 855                   

aaa gcc aga tta tcc atc act ggg agt gtg gga gag aat ggc cgc gtc       3065
Lys Ala Arg Leu Ser Ile Thr Gly Ser Val Gly Glu Asn Gly Arg Val           
        860                 865                 870                       

ttg acg cct gac tgc cca aag gct gta cac act gga act gca atc aga       3113
Leu Thr Pro Asp Cys Pro Lys Ala Val His Thr Gly Thr Ala Ile Arg           
    875                 880                 885                           

caa agt tca gga ttg gct gtc att gca tcg gac cta cca taa               3155
Gln Ser Ser Gly Leu Ala Val Ile Ala Ser Asp Leu Pro                       
890                 895                 900                               

aaaccaaaaa aataattgag tgccttaatt aaactgttgg tgactggtgg aaacgcagcc     3215

ctgagggaca cgccacgcgc gggtctttgc taaaccaatc ctttggctga gagcgggaag     3275

tccgtcctaa cgcgctggcc ggacatcagc agcagcaacg tgtgcatgag ctcagctcgg     3335

aaacccaaac tcagatttta tatcaggaaa actcacaatt gaggtttttt tcggggagtg     3395

ggtgggggag ggatctggga tgggtgtatt aacagcaaca aatttcattc gagtggactc     3455

aaaaactaat cagacttatg agttagcgca ttaaactgtg aagttcttgc tcagaaaggc     3515

ctttgtcttc accggaaagg ataaaatagt tgtagaagtc cgtgaacatg ctaacctgtg     3575

tctccagaac atccatatag tccatggaag aaaatccagc tgagaaaaca aatcactaaa     3635

ctgtgataag aaaataatga acaaacatgt aaaacctgtg ggaaaaaaaa ataaaggaag     3695

tatgtacact tactttggag aaaacaaata ctgaaacatg cttgcttttt aactgacgta     3755

aattcagtag aggacaacac aattcttttt tctaaccatc ttagggaaca atacattgca     3815

ataattgata taaatgccat cactgtaata aactttagag actttttttt ataaaagttg     3875

ttggtcatct tcttgtttgc tgtaaccttc actatgtcac atgagtcgat tcaccgattg     3935

catttgtctc acaaccagga agaaaagcaa aaggaagaaa acgtttaggt tcaatcatca     3995

gtctgcggtg tagactcgaa agagatgaca ggtcactcat gttaatggta ttatttataa     4055

tctcattctg tgtacaacat tgtggttttt gtacccacca aaaagaataa aacagcagat     4115

gttcttacaa tatctacaga gcttaaaagt tttttcttat cgttataaaa gttatttgag     4175

aaattataag actataagag agattgtatt agtggtgggc catagtggaa aatgtagcta     4235

gccctcatta ttttttgcat actaagctac ccctcctttt cagatctttg actcattaac     4295

agattaaact gtcaaagatg gagtctttga gttggggaat gaatcactgt cctaacaaca     4355

acataccttg taattgtgtg ttgaaatttt acttgactgt attttgctgc ataaaattat     4415

gtgtctcttg ggcttcttcc cttattccta ttgttccctt taaatcatat gaaggcattc     4475

ataatagctt ggggtagata acaaatgaag aattagtctt tgttttcaac tggaaattgt     4535

aaagaaaatt atactcatgt ttatttataa aaatcacctt atgtatgaat taaactaaca     4595

tggttcaaaa gaaggtttgg ttcatttgaa ataataaata agtactctaa tacagataaa     4655

aatcatgtac ttagggtatt ggcagaaagc acaagttagg atgatttcag aagtctggcc     4715

ttgaaggatg agttgagttt taacaggagg agaaggtgtt aagagccata tgagtgagca     4775

gtggcccaaa gccatgcaca tcagtggctc atttaaggaa tgaatgccat tagatgggct     4835

actgagagta cagggatatt atggaagata aagttggaaa agctgaagga ttgattttct     4895

tccatcaact ctcaagatcc cattcgccat tcaatctctg tgctgcagta agagcaatct     4955

taaacagtat aaatcacaca cacacacaca cacacacaca cacacacaca caagtccctc     5015

aggaaaaatt ccaagctctt gagaagatca catgagcccc ttcatgacct ggcgcttgct     5075

tatttcttcc aggacttctc tcacttctat ccagctattc ccgtcagcaa atgaacctcc     5135

aaagcagcac atggagcact gcatagacta tttcctcagt gcgtaactcc tccctgtctc     5195

ctctttacct gagtaacttg tactcatcct tcaatactcc aactgaattt tacttaccct     5255

gaaaagattt ccatggctat ccaccacccc cctgcctgtg agactgagtt aggtgccctt     5315

tttcatgtct ttcccccatc acggcactta ccatactgcg ttgtaattgc ctgtgtactc     5375

gtctgtataa ctactagact gtaagctcct tgagggcagg gactgtgtct atcttgttca     5435

cagttgtatc cccagcaccc agcacagtgc ctggcatatt gtaggtgctt aataaatatt     5495

tgttgaatga atg                                                        5508


<210>  484
<211>  902
<212>  PRT
<213>  Homo sapiens

<400>  484

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Glu Ser Pro Tyr Val Met Tyr Lys Lys 
            420                 425                 430         


Asn His Glu Met Phe Glu Gly Asn Asp Lys Tyr Glu Gly Tyr Cys Val 
        435                 440                 445             


Asp Leu Ala Ser Glu Ile Ala Lys His Ile Gly Ile Lys Tyr Lys Ile 
    450                 455                 460                 


Ala Ile Val Pro Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys 
465                 470                 475                 480 


Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Glu Ile 
                485                 490                 495     


Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp 
            500                 505                 510         


Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys 
        515                 520                 525             


Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala 
    530                 535                 540                 


Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val 
545                 550                 555                 560 


Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu 
                565                 570                 575     


Glu Pro Glu Asp Gly Lys Glu Gly Pro Ser Asp Gln Pro Pro Asn Glu 
            580                 585                 590         


Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln 
        595                 600                 605             


Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly 
    610                 615                 620                 


Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala 
625                 630                 635                 640 


Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu 
                645                 650                 655     


Ser Ala Glu Asp Leu Ala Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu 
            660                 665                 670         


Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val 
        675                 680                 685             


Tyr Glu Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe 
    690                 695                 700                 


Thr Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly 
705                 710                 715                 720 


Lys Phe Ala Phe Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln 
                725                 730                 735     


Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys 
            740                 745                 750         


Gly Tyr Gly Val Ala Thr Pro Lys Gly Ser Ser Leu Gly Thr Pro Val 
        755                 760                 765             


Asn Leu Ala Val Leu Lys Leu Ser Glu Ala Gly Val Leu Asp Lys Leu 
    770                 775                 780                 


Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Pro Lys Asp Ser 
785                 790                 795                 800 


Gly Ser Lys Asp Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly 
                805                 810                 815     


Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala 
            820                 825                 830         


Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys 
        835                 840                 845             


Leu Thr Phe Ser Glu Ala Ile Arg Asn Lys Ala Arg Leu Ser Ile Thr 
    850                 855                 860                 


Gly Ser Val Gly Glu Asn Gly Arg Val Leu Thr Pro Asp Cys Pro Lys 
865                 870                 875                 880 


Ala Val His Thr Gly Thr Ala Ile Arg Gln Ser Ser Gly Leu Ala Val 
                885                 890                 895     


Ile Ala Ser Asp Leu Pro 
            900         


<210>  485
<211>  6377
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (246)..(1997)

<400>  485
tccgcctcac attatctgcc caagcacagt gctgttggcc aagcctccag cagctgacgg       60

gacccagctg tagtgaggtt gcagtgattg agtaggattg gcctgcttca aagcagaggt      120

ttctcatggg aatatgctta ttaaactccc actggtgcag aaaccatgaa cagaggatga      180

acaagtgaag ttgcaatctc ctccatcaca gctcagttcc ccaacaacag gatcacaagc      240

tggag atg cct tta agg aag atg aag atc cct ttc ctc cta ctg ttc ttt      290
      Met Pro Leu Arg Lys Met Lys Ile Pro Phe Leu Leu Leu Phe Phe         
      1               5                   10                  15          

ctg tgg gaa gcc gag agc cac gca gca tca agg ccg aac atc atc ctg        338
Leu Trp Glu Ala Glu Ser His Ala Ala Ser Arg Pro Asn Ile Ile Leu           
                20                  25                  30                

gtg atg gct gac gac ctc ggc att gga gat cct ggg tgc tat ggg aac        386
Val Met Ala Asp Asp Leu Gly Ile Gly Asp Pro Gly Cys Tyr Gly Asn           
            35                  40                  45                    

aaa act atc agg act ccc aat atc gac cgg ttg gcc agt ggg gga gtg        434
Lys Thr Ile Arg Thr Pro Asn Ile Asp Arg Leu Ala Ser Gly Gly Val           
        50                  55                  60                        

aaa ctc act cag cac ctg gca gca tca ccg ctg tgc aca cca agc agg        482
Lys Leu Thr Gln His Leu Ala Ala Ser Pro Leu Cys Thr Pro Ser Arg           
    65                  70                  75                            

gca gcc ttc atg act ggc cgg tac cct gtc cga tca gga atg gca tct        530
Ala Ala Phe Met Thr Gly Arg Tyr Pro Val Arg Ser Gly Met Ala Ser           
80                  85                  90                  95            

tgg tcc cgc act gga gtt ttc ctc ttc aca gcc tct tcg gga gga ctt        578
Trp Ser Arg Thr Gly Val Phe Leu Phe Thr Ala Ser Ser Gly Gly Leu           
                100                 105                 110               

ccc acc gat gag att acc ttt gct aag ctt ctg aag gat caa ggt tat        626
Pro Thr Asp Glu Ile Thr Phe Ala Lys Leu Leu Lys Asp Gln Gly Tyr           
            115                 120                 125                   

tca aca gca ctg ata ggg aaa tgg cac ctt ggg atg agc tgt cac agc        674
Ser Thr Ala Leu Ile Gly Lys Trp His Leu Gly Met Ser Cys His Ser           
        130                 135                 140                       

aag act gac ttc tgt cac cac cct tta cat cac ggc ttc aat tat ttc        722
Lys Thr Asp Phe Cys His His Pro Leu His His Gly Phe Asn Tyr Phe           
    145                 150                 155                           

tat ggg atc tct ttg acc aat ctg aga gac tgc aag ccc gga gag ggc        770
Tyr Gly Ile Ser Leu Thr Asn Leu Arg Asp Cys Lys Pro Gly Glu Gly           
160                 165                 170                 175           

agt gtc ttc acc acg ggc ttc aag agg ctg gtc ttc ctc ccc ctg cag        818
Ser Val Phe Thr Thr Gly Phe Lys Arg Leu Val Phe Leu Pro Leu Gln           
                180                 185                 190               

atc gtc ggg gtc acc ctc ctt acc ctt gct gca ctc aat tgt ctg ggg        866
Ile Val Gly Val Thr Leu Leu Thr Leu Ala Ala Leu Asn Cys Leu Gly           
            195                 200                 205                   

cta ctc cac gtg cct cta ggc gtt ttt ttc agc ctt ctc ttc cta gca        914
Leu Leu His Val Pro Leu Gly Val Phe Phe Ser Leu Leu Phe Leu Ala           
        210                 215                 220                       

gcc cta atc ctg acc ctt ttc ttg ggc ttc ctt cat tac ttc cgg ccc        962
Ala Leu Ile Leu Thr Leu Phe Leu Gly Phe Leu His Tyr Phe Arg Pro           
    225                 230                 235                           

ctg aac tgc ttc atg atg agg aac tac gag atc att cag cag ccc atg       1010
Leu Asn Cys Phe Met Met Arg Asn Tyr Glu Ile Ile Gln Gln Pro Met           
240                 245                 250                 255           

tcc tat gac aat ctc acc cag agg cta acg gtg gag gcg gcc cag ttc       1058
Ser Tyr Asp Asn Leu Thr Gln Arg Leu Thr Val Glu Ala Ala Gln Phe           
                260                 265                 270               

ata cag cgg aac act gag act ccg ttc ctg ctt gtc ttg tcc tac ctc       1106
Ile Gln Arg Asn Thr Glu Thr Pro Phe Leu Leu Val Leu Ser Tyr Leu           
            275                 280                 285                   

cac gtg cac aca gcc ctg ttc tcc agc aaa gac ttt gct ggc aaa agt       1154
His Val His Thr Ala Leu Phe Ser Ser Lys Asp Phe Ala Gly Lys Ser           
        290                 295                 300                       

caa cac gga gtc tac ggg gat gct gtt gag gaa atg gac tgg agt gtg       1202
Gln His Gly Val Tyr Gly Asp Ala Val Glu Glu Met Asp Trp Ser Val           
    305                 310                 315                           

ggg cag atc ttg aac ctt ctg gat gag ctg aga ttg gct aat gat acc       1250
Gly Gln Ile Leu Asn Leu Leu Asp Glu Leu Arg Leu Ala Asn Asp Thr           
320                 325                 330                 335           

ctc atc tac ttc aca tcg gac cag gga gca cat gta gaa gaa gtg tct       1298
Leu Ile Tyr Phe Thr Ser Asp Gln Gly Ala His Val Glu Glu Val Ser           
                340                 345                 350               

tcc aaa gga gaa att cat ggc gga agt aat ggg atc tat aaa gga gga       1346
Ser Lys Gly Glu Ile His Gly Gly Ser Asn Gly Ile Tyr Lys Gly Gly           
            355                 360                 365                   

aaa gca aac aac tgg gaa gga ggt atc cgg gtt cca ggc atc ctt cgt       1394
Lys Ala Asn Asn Trp Glu Gly Gly Ile Arg Val Pro Gly Ile Leu Arg           
        370                 375                 380                       

tgg ccc agg gtg ata cag gct ggc cag aag att gat gag ccc act agc       1442
Trp Pro Arg Val Ile Gln Ala Gly Gln Lys Ile Asp Glu Pro Thr Ser           
    385                 390                 395                           

aac atg gac ata ttt cct aca gta gcc aag ctg gct gga gct ccc ttg       1490
Asn Met Asp Ile Phe Pro Thr Val Ala Lys Leu Ala Gly Ala Pro Leu           
400                 405                 410                 415           

cct gag gac agg atc att gat gga cgt gat ctg atg ccc ctg ctt gaa       1538
Pro Glu Asp Arg Ile Ile Asp Gly Arg Asp Leu Met Pro Leu Leu Glu           
                420                 425                 430               

gga aaa agc caa cgc tcc gat cat gag ttt ctc ttc cat tac tgc aac       1586
Gly Lys Ser Gln Arg Ser Asp His Glu Phe Leu Phe His Tyr Cys Asn           
            435                 440                 445                   

gcc tac tta aat gct gtg cgc tgg cac cct cag aac agc aca tcc atc       1634
Ala Tyr Leu Asn Ala Val Arg Trp His Pro Gln Asn Ser Thr Ser Ile           
        450                 455                 460                       

tgg aag gcc ttt ttc ttc acc ccc aac ttc aac ccc gtg ggt tcc aac       1682
Trp Lys Ala Phe Phe Phe Thr Pro Asn Phe Asn Pro Val Gly Ser Asn           
    465                 470                 475                           

gga tgc ttt gcc aca cac gtg tgc ttc tgt ttc ggg agt tat gtc acc       1730
Gly Cys Phe Ala Thr His Val Cys Phe Cys Phe Gly Ser Tyr Val Thr           
480                 485                 490                 495           

cat cac gac cca cct tta ctc ttt gat att tcc aaa gat ccc aga gag       1778
His His Asp Pro Pro Leu Leu Phe Asp Ile Ser Lys Asp Pro Arg Glu           
                500                 505                 510               

aga aac cca cta act cca gca tcc gag ccc cgg ttt tat gaa atc ctc       1826
Arg Asn Pro Leu Thr Pro Ala Ser Glu Pro Arg Phe Tyr Glu Ile Leu           
            515                 520                 525                   

aaa gtc atg cag gaa gct gcg gac aga cac acc cag acc ctg cca gag       1874
Lys Val Met Gln Glu Ala Ala Asp Arg His Thr Gln Thr Leu Pro Glu           
        530                 535                 540                       

gtg ccc gat cag ttt tca tgg aac aac ttt ctt tgg aag ccc tgg ctt       1922
Val Pro Asp Gln Phe Ser Trp Asn Asn Phe Leu Trp Lys Pro Trp Leu           
    545                 550                 555                           

cag ctg tgc tgt cct tcc acc ggc ctg tct tgc cag tgt gat aga gaa       1970
Gln Leu Cys Cys Pro Ser Thr Gly Leu Ser Cys Gln Cys Asp Arg Glu           
560                 565                 570                 575           

aaa cag gat aag aga ctg agc cgc tag cagcgcctgg ggaccagaca             2017
Lys Gln Asp Lys Arg Leu Ser Arg                                           
                580                                                       

gacgcatgtg gcaaagctca ccatcttcac tacaaacacg cctgagagtg gcactgggga     2077

aacataactc catctacacc ttggatttgg actgattctc cattttatca cctgaaggct     2137

tgggccagag ctcaacagct actcaactgg aggggtgagg gggataaggt ctgtagtata     2197

cagacaggaa gatggtaggt ttatgccttc tgtggccaga gtcttggact catggaaata     2257

gaatgaatag aggggcattc acaaggcaca ccagtgcaag cagatgacaa aaaggtgcag     2317

aaggcaatct taaaacagaa aggtgcagga ggtaccttaa ctcacccctc agcaaatacc     2377

tatgtcaaca gtataagtta ccatttactc tataatctgc agtgatgcaa taaccagcat     2437

aataaaaagg caatcacata aaaaagagtt tagtcgtcta aacataagta actttaaggt     2497

gaatgaaaga tcttctttag gaataataga tgatggtaag ttccactttg gttattggaa     2557

ggcaagtcat tattactggt attagttaaa acacatatca aatgcttgct cttcatcata     2617

tatatagtta tgcatacata cacacacaca catacagtat attctttcct caaaagggtt     2677

aagatgtcta aaatagggac ctagaagctt aacactattt aagtaaatac agtagaagct     2737

cacaaataga tttctttgca caatgatttt ttgcaaaatt ttacagtaat aataatccca     2797

aggcaaatct ctcctgaact gctttccatt ccataatttg tagtataatt cttggattcc     2857

actgttttct ttggggaatg gaagttctga attaaaagcc cactgtggag atgctgtggt     2917

tcatggaatc tcttccagtg taattcagaa tcattggcct agaaagtctc tgatatttgg     2977

aggggaacaa aaatcactca caagcaatcc atgatctata cacataagca taatttcctt     3037

tagttctagt tagtcatcag agaacagtca tgtatgcaag ttttgtgact gagaaatttc     3097

tgtgcttcca atccacaatg agatgcatga ttttgttttc atcccatttc ccccaagccc     3157

ctgtaaatca gggaaaatgc gcaactgatc gcctaggaga gggcctcgta gtggcacagc     3217

tggagatagt ttcaaagtct aaaccaccag cccatcctga ggaaagcctc ctatggaatg     3277

taaagtgcaa tcatttcttc agatataaga ctttccccaa caatgtgatt ggattccttt     3337

atggcaaaat cgagagaagc tgccatccac ctgcttatgc atttatctct tttgtggact     3397

tgtctgacca ccttctattt gcccagagtt tgctcaattc caagacagtg cccatgaatg     3457

ggacacctgt aatgtaaccc acacagcggt ttgcagagaa tgttagccat gacttgggct     3517

ttctgaaagt tggctataat ttctctatcc ctacccacaa ccctgggaag ttggagcaag     3577

aggggcatac tattgggctg ggaggatttg acagcatttc cccagttgcc ctttaagttc     3637

ttctatttca aacgttaatt ttgcttctct ttctaaaaaa aaaaaaaaaa aagaaagaga     3697

agaaagaagt gattcctacc ccctacctcc agagttgttg aaagctgaaa agcatacaag     3757

attcttcctt ttaacttgga tttctcgttc cagaaattgt gggataatct gtattcttgc     3817

tttagaaaac attcttagag agggtactag cttactgatg atgtgttagg attgctactg     3877

atgctgtcat gtggaaacta tttaaaggca ctattataaa tttatcctat aagatgacaa     3937

tgtttactca aagtctaaca tattcaatgc aagtaagact ttctgaaaac acttgatgat     3997

gtggaaatgc tgcaggatta aataacttga agagccttta tagattatat gaatgcctat     4057

ttgtgtctag aaccagttat ttaacctgta aaatgtcaat agcaaatgaa ggatgaagta     4117

tatctctaga tgcaaataca ttgagtttaa aagtgcctca aaataattga gatcacattt     4177

caggacattt ggaaatcagg tcgatttgtg gtaactgtag tcatcttaaa tttcaaacca     4237

tttaccatct gaaagttttg atttgaatgt aaaacaggaa attggaattc ctttgtccag     4297

gagaaacctc acaaaccttc tttaaggcat agttttgttg tttgtttgct tgtttgttgc     4357

aggctgtaag gcatggctgc ttgtttacaa agcatctcat tcatattacc tgtggagttg     4417

catatccaaa ccttagtgag ttttgaagct ttaagcaaat tcttttaaaa aattcttgta     4477

tttctagcat tactagatat taaaagttaa gcaaatagat taatgacgta tacataggca     4537

tcatttcaca aggtcagtaa tgctgcagga aaagcaaaat tgcaatctac gtatctatgg     4597

tactaaggaa gtcctgtttt tcaaaaatgg aagcccactt ctcagatttt tctgaagggc     4657

atacaatgaa aagtgaaggg gaaacacaca cacacaaaaa aacaagtatt tggcttgtca     4717

caggaatctg attgcattaa gtgaaaggat tatttagaat atgttaatgc aaagctaaaa     4777

taaaattttc cttggcaatt aaaaatgctg tgcgctaata ccctgctttc tatcgtgact     4837

caattcaaca atgtggggaa tgtttactac atttccaact tgatgtcaag caatggggaa     4897

tacaagttcc agttctgcaa agattcgtca actttcttag ctcaagagag aggctgagaa     4957

atgcagagaa gaataagaca taaaatagct ccgacctcca tgatccgaga gtgggaaaag     5017

gcccgattat tacccataag gcacactctc taaggccttt taaggggcct acaaaaatgt     5077

tttattttat aatcagaaga aaaggaaatg aacattgggg attgaaaatc atattggtat     5137

ttgcaccaac atagtcataa aatagtatgt taatatgttt ttactttata tatttatata     5197

ttaaaatata tttaatatgt tttgcctttg tggcccatga aagtcttact gggccctggg     5257

gaaggtatcc taccctggtg aagcagctgc tttgctctac aaatacctgg ggcagaaatt     5317

tgatttgaaa agtattattc tctcttctct ttgtttcaac tggattcctt tggaaaacca     5377

aactagtatc agaacaaacc ccgaaacagt aagaaattgg agtgagaagg gcatggtatt     5437

gggactagga tcggctctca ttcgatcgag ctattctctt aaaatgacaa aaagtgtcca     5497

taaagaggct gctggagagt gcgtggccat agggagccga catgcccggg aggaaaggtg     5557

ttgattacat ggatacttct aaaagctaaa gccttgttgc cttctcttta atgcctagag     5617

aatgggatgt gtgatgcaaa tgctcaaaac ctcttaaatc atagctgtct gacctctacg     5677

gacctcacat ccatctgagg cttcatggac aaagattctc cacttggcca aactttagcc     5737

aagctcctca accttctccc aggcccaatc tgggcacttc cttgtaaaat ctagttttgg     5797

caagaagtct attaggtcag tttagcaaga acacctaacc cccccatatc tgttcaacct     5857

cagtatctga tcaggctcct cagcctccac catcccccag gtgatgtctg gtcaactggc     5917

ctgccttcag ctagaatcct gttaggtcgg tttagatgaa tgctccctga tatttcctct     5977

tggtaatctt ccatccactg cccctgaccc tgttccctgt ctataaatcc ccagttttcc     6037

atggtgtatt cagagctgag tccagtctct ctcccctact acaagtcccc attgctgtgg     6097

tccccgtacc tgtcatgatg gtcctaaata aagtcttact gtgctttaat aggtagcatt     6157

gaaaaatttt tttctttgac atcattcatg acaacatgaa acctattggg acagcatgac     6217

tgtgcagggt ctttagagct cagctttctg aggccctgag cattcttggt tttccgacat     6277

cgtgaacctg ttctgtgttg caagatatca ctcaagccag tgttgcttaa taccatctct     6337

ttgtgtaata gatctgaata aagtaattgt aatacaccaa                           6377


<210>  486
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  486

Met Pro Leu Arg Lys Met Lys Ile Pro Phe Leu Leu Leu Phe Phe Leu 
1               5                   10                  15      


Trp Glu Ala Glu Ser His Ala Ala Ser Arg Pro Asn Ile Ile Leu Val 
            20                  25                  30          


Met Ala Asp Asp Leu Gly Ile Gly Asp Pro Gly Cys Tyr Gly Asn Lys 
        35                  40                  45              


Thr Ile Arg Thr Pro Asn Ile Asp Arg Leu Ala Ser Gly Gly Val Lys 
    50                  55                  60                  


Leu Thr Gln His Leu Ala Ala Ser Pro Leu Cys Thr Pro Ser Arg Ala 
65                  70                  75                  80  


Ala Phe Met Thr Gly Arg Tyr Pro Val Arg Ser Gly Met Ala Ser Trp 
                85                  90                  95      


Ser Arg Thr Gly Val Phe Leu Phe Thr Ala Ser Ser Gly Gly Leu Pro 
            100                 105                 110         


Thr Asp Glu Ile Thr Phe Ala Lys Leu Leu Lys Asp Gln Gly Tyr Ser 
        115                 120                 125             


Thr Ala Leu Ile Gly Lys Trp His Leu Gly Met Ser Cys His Ser Lys 
    130                 135                 140                 


Thr Asp Phe Cys His His Pro Leu His His Gly Phe Asn Tyr Phe Tyr 
145                 150                 155                 160 


Gly Ile Ser Leu Thr Asn Leu Arg Asp Cys Lys Pro Gly Glu Gly Ser 
                165                 170                 175     


Val Phe Thr Thr Gly Phe Lys Arg Leu Val Phe Leu Pro Leu Gln Ile 
            180                 185                 190         


Val Gly Val Thr Leu Leu Thr Leu Ala Ala Leu Asn Cys Leu Gly Leu 
        195                 200                 205             


Leu His Val Pro Leu Gly Val Phe Phe Ser Leu Leu Phe Leu Ala Ala 
    210                 215                 220                 


Leu Ile Leu Thr Leu Phe Leu Gly Phe Leu His Tyr Phe Arg Pro Leu 
225                 230                 235                 240 


Asn Cys Phe Met Met Arg Asn Tyr Glu Ile Ile Gln Gln Pro Met Ser 
                245                 250                 255     


Tyr Asp Asn Leu Thr Gln Arg Leu Thr Val Glu Ala Ala Gln Phe Ile 
            260                 265                 270         


Gln Arg Asn Thr Glu Thr Pro Phe Leu Leu Val Leu Ser Tyr Leu His 
        275                 280                 285             


Val His Thr Ala Leu Phe Ser Ser Lys Asp Phe Ala Gly Lys Ser Gln 
    290                 295                 300                 


His Gly Val Tyr Gly Asp Ala Val Glu Glu Met Asp Trp Ser Val Gly 
305                 310                 315                 320 


Gln Ile Leu Asn Leu Leu Asp Glu Leu Arg Leu Ala Asn Asp Thr Leu 
                325                 330                 335     


Ile Tyr Phe Thr Ser Asp Gln Gly Ala His Val Glu Glu Val Ser Ser 
            340                 345                 350         


Lys Gly Glu Ile His Gly Gly Ser Asn Gly Ile Tyr Lys Gly Gly Lys 
        355                 360                 365             


Ala Asn Asn Trp Glu Gly Gly Ile Arg Val Pro Gly Ile Leu Arg Trp 
    370                 375                 380                 


Pro Arg Val Ile Gln Ala Gly Gln Lys Ile Asp Glu Pro Thr Ser Asn 
385                 390                 395                 400 


Met Asp Ile Phe Pro Thr Val Ala Lys Leu Ala Gly Ala Pro Leu Pro 
                405                 410                 415     


Glu Asp Arg Ile Ile Asp Gly Arg Asp Leu Met Pro Leu Leu Glu Gly 
            420                 425                 430         


Lys Ser Gln Arg Ser Asp His Glu Phe Leu Phe His Tyr Cys Asn Ala 
        435                 440                 445             


Tyr Leu Asn Ala Val Arg Trp His Pro Gln Asn Ser Thr Ser Ile Trp 
    450                 455                 460                 


Lys Ala Phe Phe Phe Thr Pro Asn Phe Asn Pro Val Gly Ser Asn Gly 
465                 470                 475                 480 


Cys Phe Ala Thr His Val Cys Phe Cys Phe Gly Ser Tyr Val Thr His 
                485                 490                 495     


His Asp Pro Pro Leu Leu Phe Asp Ile Ser Lys Asp Pro Arg Glu Arg 
            500                 505                 510         


Asn Pro Leu Thr Pro Ala Ser Glu Pro Arg Phe Tyr Glu Ile Leu Lys 
        515                 520                 525             


Val Met Gln Glu Ala Ala Asp Arg His Thr Gln Thr Leu Pro Glu Val 
    530                 535                 540                 


Pro Asp Gln Phe Ser Trp Asn Asn Phe Leu Trp Lys Pro Trp Leu Gln 
545                 550                 555                 560 


Leu Cys Cys Pro Ser Thr Gly Leu Ser Cys Gln Cys Asp Arg Glu Lys 
                565                 570                 575     


Gln Asp Lys Arg Leu Ser Arg 
            580             


<210>  487
<211>  2629
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (393)..(1424)

<400>  487
accgccccgc gctccgctgc caggggcggg agggaggaat ggttgcttca cgccccgggg       60

gaagagacgg gaagctcggc tctgggttgc gggccccggc gtctccgcgt ggggcgcacc      120

gtccgacccc cccctcccgg tgtgcagcgc cccgcaccgc cccgcctcgc ctgggagaag      180

ccgccgggac gcgccgggct ggagtgggcg gttataggct ttgagctagg ccgtttccgg      240

gaggcggagc tcagacccca tttcctttct ccacatccag gtcaggtggc gtttgctgtg      300

gcggctaggc ccgcgtgcgc tggagacctc cgcgctggcc cccgcgagcc tcctgccctg      360

gcccggcgct gcggctctgc cgcggcggca gc atg ggt ggc ccc cgg ggc gcg        413
                                    Met Gly Gly Pro Arg Gly Ala           
                                    1               5                     

ggc tgg gtg gcg gcg ggc ctg ctg ctc ggc gcg ggc gcc tgc tac tgc        461
Gly Trp Val Ala Ala Gly Leu Leu Leu Gly Ala Gly Ala Cys Tyr Cys           
        10                  15                  20                        

att tac agg ctg acc cgg ggt cgg cgg cgg ggc gac cgc gag ctc ggg        509
Ile Tyr Arg Leu Thr Arg Gly Arg Arg Arg Gly Asp Arg Glu Leu Gly           
    25                  30                  35                            

ata cgc tct tcg aag tcc gca ggt gcc ctg gaa gaa ggg acg tca gag        557
Ile Arg Ser Ser Lys Ser Ala Gly Ala Leu Glu Glu Gly Thr Ser Glu           
40                  45                  50                  55            

ggt cag ttg tgc ggg cgc tcg gcc cgg cct cag acg gga ggt acc tgg        605
Gly Gln Leu Cys Gly Arg Ser Ala Arg Pro Gln Thr Gly Gly Thr Trp           
                60                  65                  70                

gag tca cag tgg tcc aag acc tcg cag cct gaa gac tta act gat ggt        653
Glu Ser Gln Trp Ser Lys Thr Ser Gln Pro Glu Asp Leu Thr Asp Gly           
            75                  80                  85                    

tca tat gat gat gtt cta aat gct gaa caa ctt cag aaa ctc ctt tac        701
Ser Tyr Asp Asp Val Leu Asn Ala Glu Gln Leu Gln Lys Leu Leu Tyr           
        90                  95                  100                       

ctg ctg gag tca acg gag gat cct gta att att gaa aga gct ttg att        749
Leu Leu Glu Ser Thr Glu Asp Pro Val Ile Ile Glu Arg Ala Leu Ile           
    105                 110                 115                           

act ttg ggt aac aat gca gcc ttt tca gtt aac caa gct att att cgt        797
Thr Leu Gly Asn Asn Ala Ala Phe Ser Val Asn Gln Ala Ile Ile Arg           
120                 125                 130                 135           

gaa ttg ggt ggt att cca att gtt gca aac aaa atc aac cat tcc aac        845
Glu Leu Gly Gly Ile Pro Ile Val Ala Asn Lys Ile Asn His Ser Asn           
                140                 145                 150               

cag agt att aaa gag aaa gct tta aat gca cta aat aac ctg agt gtg        893
Gln Ser Ile Lys Glu Lys Ala Leu Asn Ala Leu Asn Asn Leu Ser Val           
            155                 160                 165                   

aat gtt gaa aat caa atc aag ata aag ata tac atc agt caa gta tgt        941
Asn Val Glu Asn Gln Ile Lys Ile Lys Ile Tyr Ile Ser Gln Val Cys           
        170                 175                 180                       

gag gat gtc ttc tct ggt cct ctg aac tct gct gtg cag ctg gct gga        989
Glu Asp Val Phe Ser Gly Pro Leu Asn Ser Ala Val Gln Leu Ala Gly           
    185                 190                 195                           

ctg aca ttg ttg aca aac atg act gtt acc aat gac cac cag cac atg       1037
Leu Thr Leu Leu Thr Asn Met Thr Val Thr Asn Asp His Gln His Met           
200                 205                 210                 215           

ctt cac agt tac att aca gac ctg ttc cag gtg tta ctt act gga aat       1085
Leu His Ser Tyr Ile Thr Asp Leu Phe Gln Val Leu Leu Thr Gly Asn           
                220                 225                 230               

gga aac acg aag gtg caa gtt ttg aaa ctg ctt ttg aat ttg tct gaa       1133
Gly Asn Thr Lys Val Gln Val Leu Lys Leu Leu Leu Asn Leu Ser Glu           
            235                 240                 245                   

aat cca gcc atg aca gaa gga ctt ctc cgt gcc caa gtg gat tca tca       1181
Asn Pro Ala Met Thr Glu Gly Leu Leu Arg Ala Gln Val Asp Ser Ser           
        250                 255                 260                       

ttc ctt tcc ctt tat gac agc cac gta gca aag gag att ctt ctt cga       1229
Phe Leu Ser Leu Tyr Asp Ser His Val Ala Lys Glu Ile Leu Leu Arg           
    265                 270                 275                           

gta ctt acg cta ttt cag aat ata aag aac tgc ctc aaa ata gaa ggc       1277
Val Leu Thr Leu Phe Gln Asn Ile Lys Asn Cys Leu Lys Ile Glu Gly           
280                 285                 290                 295           

cat tta gct gtg cag cct act ttc act gaa ggt tca ttg ttt ttc ctg       1325
His Leu Ala Val Gln Pro Thr Phe Thr Glu Gly Ser Leu Phe Phe Leu           
                300                 305                 310               

tta cat gga gaa gaa tgt gcc cag aaa ata aga gct tta gtt gat cac       1373
Leu His Gly Glu Glu Cys Ala Gln Lys Ile Arg Ala Leu Val Asp His           
            315                 320                 325                   

cat gat gca gag gtg aag gaa aag gtt gta aca ata ata ccc aaa atc       1421
His Asp Ala Glu Val Lys Glu Lys Val Val Thr Ile Ile Pro Lys Ile           
        330                 335                 340                       

tga ttggtcatat ttttccaaag agtaatgcag tctggatata aatgtatttt            1474

ctgtcttcct tataagggga ttctcccagc tgctaaattt aaacagtaaa tatcacattt     1534

tgtcattaac acagctataa cttgccgtgg ttctcagatt tattttggac tattttgatg     1594

ccaagtgaat ataagagttt gtactgaaac catttatttc tttctatttt gctatttgca     1654

aatgcttgtt atcttcccta catgaagtgg cagtaacctt tttcacattt aagctaccct     1714

tctacctttt gaagtgattt gcagttactc atctgagaca gcatcagtat ttgactaaat     1774

cattgtttca caactgaata gtcttgttct tttagtagca atgaaatcct aagctcttga     1834

ggccattcac ctgccaacct gaccatactg ctttcaaaag tcttttctca tcagtagaat     1894

ctattttggt cacttctagt caatgaaaaa tgtaaacttt taggagagaa tgtttcctag     1954

gactcaccca ctccattcaa tgttacatat aaaatagtgt gatcaatcac aatgtccatc     2014

tttagacagt tggttaaata aattatctgg tctttgaaaa gaccgtgctg ggcgcggtgg     2074

ctcttgcctg taatcccagc actttgggag gctgaggcgg gcagatcacc tgagatcggg     2134

agtttgagac caagcctgac caatatggag aaaccctgtc tctactaaga atacaaaatt     2194

agctgggcat ggtggtgcat gcctgtaatc ccagctactt gggaggccga ggcaggagaa     2254

ttgcttgaac ccgggaggca gaggttgcag tgaggtgaga tagcgccatt gcactccagc     2314

ctgggcaaca agagcaaaac tctgtctcaa aaaaaaaaaa aaatgatgga gctccgaatg     2374

tgcttaagtg gaaagatatc tatgaaatat ggtggttttt taaaacacaa aaattataga     2434

atatgggatc ccgtgtgtgt gtgtgtgtgt ttgaatgaaa aatgcttatg tattgacaga     2494

acacttctag aatgataccc aaactcctgg agtgggagtg gggaatgcct tctacgtaca     2554

cactgttcta ctgtttgaat tttttaatat gagcccaaat tgtataatct ttttttaata     2614

aaggggagaa aaatc                                                      2629


<210>  488
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  488

Met Gly Gly Pro Arg Gly Ala Gly Trp Val Ala Ala Gly Leu Leu Leu 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Arg 
            20                  25                  30          


Arg Gly Asp Arg Glu Leu Gly Ile Arg Ser Ser Lys Ser Ala Gly Ala 
        35                  40                  45              


Leu Glu Glu Gly Thr Ser Glu Gly Gln Leu Cys Gly Arg Ser Ala Arg 
    50                  55                  60                  


Pro Gln Thr Gly Gly Thr Trp Glu Ser Gln Trp Ser Lys Thr Ser Gln 
65                  70                  75                  80  


Pro Glu Asp Leu Thr Asp Gly Ser Tyr Asp Asp Val Leu Asn Ala Glu 
                85                  90                  95      


Gln Leu Gln Lys Leu Leu Tyr Leu Leu Glu Ser Thr Glu Asp Pro Val 
            100                 105                 110         


Ile Ile Glu Arg Ala Leu Ile Thr Leu Gly Asn Asn Ala Ala Phe Ser 
        115                 120                 125             


Val Asn Gln Ala Ile Ile Arg Glu Leu Gly Gly Ile Pro Ile Val Ala 
    130                 135                 140                 


Asn Lys Ile Asn His Ser Asn Gln Ser Ile Lys Glu Lys Ala Leu Asn 
145                 150                 155                 160 


Ala Leu Asn Asn Leu Ser Val Asn Val Glu Asn Gln Ile Lys Ile Lys 
                165                 170                 175     


Ile Tyr Ile Ser Gln Val Cys Glu Asp Val Phe Ser Gly Pro Leu Asn 
            180                 185                 190         


Ser Ala Val Gln Leu Ala Gly Leu Thr Leu Leu Thr Asn Met Thr Val 
        195                 200                 205             


Thr Asn Asp His Gln His Met Leu His Ser Tyr Ile Thr Asp Leu Phe 
    210                 215                 220                 


Gln Val Leu Leu Thr Gly Asn Gly Asn Thr Lys Val Gln Val Leu Lys 
225                 230                 235                 240 


Leu Leu Leu Asn Leu Ser Glu Asn Pro Ala Met Thr Glu Gly Leu Leu 
                245                 250                 255     


Arg Ala Gln Val Asp Ser Ser Phe Leu Ser Leu Tyr Asp Ser His Val 
            260                 265                 270         


Ala Lys Glu Ile Leu Leu Arg Val Leu Thr Leu Phe Gln Asn Ile Lys 
        275                 280                 285             


Asn Cys Leu Lys Ile Glu Gly His Leu Ala Val Gln Pro Thr Phe Thr 
    290                 295                 300                 


Glu Gly Ser Leu Phe Phe Leu Leu His Gly Glu Glu Cys Ala Gln Lys 
305                 310                 315                 320 


Ile Arg Ala Leu Val Asp His His Asp Ala Glu Val Lys Glu Lys Val 
                325                 330                 335     


Val Thr Ile Ile Pro Lys Ile 
            340             


<210>  489
<211>  1595
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (99)..(1052)

<400>  489
gagtgagtga gagggcagag gaaatactca atctgtgcca ctcactgcct tgagcctgct       60

tcctcactcc aggactgcca gaggaagcaa tcaccaaa atg aag act gct tta att      116
                                          Met Lys Thr Ala Leu Ile         
                                          1               5               

ttg ctc agc att ttg gga atg gcc tgt gct ttc tca atg aaa aat ttg        164
Leu Leu Ser Ile Leu Gly Met Ala Cys Ala Phe Ser Met Lys Asn Leu           
            10                  15                  20                    

cat cga aga gtc aaa ata gag gat tct gaa gaa aat ggg gtc ttt aag        212
His Arg Arg Val Lys Ile Glu Asp Ser Glu Glu Asn Gly Val Phe Lys           
        25                  30                  35                        

tac agg cca cga tat tat ctt tac aag cat gcc tac ttt tat cct cat        260
Tyr Arg Pro Arg Tyr Tyr Leu Tyr Lys His Ala Tyr Phe Tyr Pro His           
    40                  45                  50                            

tta aaa cga ttt cca gtt cag ggc agt agt gac tca tcc gaa gaa aat        308
Leu Lys Arg Phe Pro Val Gln Gly Ser Ser Asp Ser Ser Glu Glu Asn           
55                  60                  65                  70            

gga gat gac agt tca gaa gag gag gag gaa gaa gag gag act tca aat        356
Gly Asp Asp Ser Ser Glu Glu Glu Glu Glu Glu Glu Glu Thr Ser Asn           
                75                  80                  85                

gaa gga gaa aac aat gaa gaa tcg aat gaa gat gaa gac tct gag gct        404
Glu Gly Glu Asn Asn Glu Glu Ser Asn Glu Asp Glu Asp Ser Glu Ala           
            90                  95                  100                   

gag aat acc aca ctt tct gct aca aca ctg ggc tat gga gag gac gcc        452
Glu Asn Thr Thr Leu Ser Ala Thr Thr Leu Gly Tyr Gly Glu Asp Ala           
        105                 110                 115                       

acg cct ggc aca ggg tat aca ggg tta gct gca atc cag ctt ccc aag        500
Thr Pro Gly Thr Gly Tyr Thr Gly Leu Ala Ala Ile Gln Leu Pro Lys           
    120                 125                 130                           

aag gct ggg gat ata aca aat aaa gct aca aaa gag aag gaa agt gat        548
Lys Ala Gly Asp Ile Thr Asn Lys Ala Thr Lys Glu Lys Glu Ser Asp           
135                 140                 145                 150           

gaa gaa gaa gag gag gaa gag gaa gga aat gaa aac gaa gaa agc gaa        596
Glu Glu Glu Glu Glu Glu Glu Glu Gly Asn Glu Asn Glu Glu Ser Glu           
                155                 160                 165               

gca gaa gtg gat gaa aac gaa caa ggc ata aac ggc acc agt acc aac        644
Ala Glu Val Asp Glu Asn Glu Gln Gly Ile Asn Gly Thr Ser Thr Asn           
            170                 175                 180                   

agc aca gag gca gaa aac ggc aac ggc agc agc gga gga gac aat gga        692
Ser Thr Glu Ala Glu Asn Gly Asn Gly Ser Ser Gly Gly Asp Asn Gly           
        185                 190                 195                       

gaa gaa ggg gaa gaa gaa agt gtc act gga gcc aat gca gaa gac acc        740
Glu Glu Gly Glu Glu Glu Ser Val Thr Gly Ala Asn Ala Glu Asp Thr           
    200                 205                 210                           

aca gag acc gga agg cag ggc aag ggc acc tcg aag aca aca acc tct        788
Thr Glu Thr Gly Arg Gln Gly Lys Gly Thr Ser Lys Thr Thr Thr Ser           
215                 220                 225                 230           

cca aat ggt ggg ttt gaa cct aca acc cca cca caa gtc tat aga acc        836
Pro Asn Gly Gly Phe Glu Pro Thr Thr Pro Pro Gln Val Tyr Arg Thr           
                235                 240                 245               

act tcc cca cct ttt ggg aaa acc acc acc gtt gaa tac gag ggg gag        884
Thr Ser Pro Pro Phe Gly Lys Thr Thr Thr Val Glu Tyr Glu Gly Glu           
            250                 255                 260                   

tac gaa tac acg ggc gcc aat gaa tac gac aat gga tat gaa atc tat        932
Tyr Glu Tyr Thr Gly Ala Asn Glu Tyr Asp Asn Gly Tyr Glu Ile Tyr           
        265                 270                 275                       

gaa agt gag aac ggg gaa cct cgt ggg gac aat tac cga gcc tat gaa        980
Glu Ser Glu Asn Gly Glu Pro Arg Gly Asp Asn Tyr Arg Ala Tyr Glu           
    280                 285                 290                           

gat gag tac agc tac ttt aaa gga caa ggc tac gat ggc tat gat ggt       1028
Asp Glu Tyr Ser Tyr Phe Lys Gly Gln Gly Tyr Asp Gly Tyr Asp Gly           
295                 300                 305                 310           

cag aat tac tac cac cac cag tga agctccagcc tgggatgaat tcatccattc      1082
Gln Asn Tyr Tyr His His Gln                                               
                315                                                       

tggctttgca tccggctacc attttcgaag ttcaactcag gaaggtgcaa tataacaaat     1142

gtgcatatta taatgaggaa tggtactacc gttccagatt ttctgtaatt gcttctgcaa     1202

agtaataggc ttcttgtccc ttttttttct ggcatgttat ggaatgatca ttgtaaatca     1262

ggaccattta tcaagcagta caccaactca taagatcaaa tttcattgaa tggtttgagg     1322

ttgtagctct ataaatagta gtttttaaca tgcctgtagt attgctaact gcaaaaacat     1382

actctttgta caagaagtgc ttctaagaat ttcattgaca ttaatgacac tgtatacaat     1442

aaatgtgtag tttcttaatc gcactaccta tgcaacactg tgtattaggt ttatcatcct     1502

catgtatttt tatgtgacct gtatgtatat tctaatctac gagttttatc acaaataaaa     1562

atgcaatcct tcaaatgtgt tataattaaa aaa                                  1595


<210>  490
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  490

Met Lys Thr Ala Leu Ile Leu Leu Ser Ile Leu Gly Met Ala Cys Ala 
1               5                   10                  15      


Phe Ser Met Lys Asn Leu His Arg Arg Val Lys Ile Glu Asp Ser Glu 
            20                  25                  30          


Glu Asn Gly Val Phe Lys Tyr Arg Pro Arg Tyr Tyr Leu Tyr Lys His 
        35                  40                  45              


Ala Tyr Phe Tyr Pro His Leu Lys Arg Phe Pro Val Gln Gly Ser Ser 
    50                  55                  60                  


Asp Ser Ser Glu Glu Asn Gly Asp Asp Ser Ser Glu Glu Glu Glu Glu 
65                  70                  75                  80  


Glu Glu Glu Thr Ser Asn Glu Gly Glu Asn Asn Glu Glu Ser Asn Glu 
                85                  90                  95      


Asp Glu Asp Ser Glu Ala Glu Asn Thr Thr Leu Ser Ala Thr Thr Leu 
            100                 105                 110         


Gly Tyr Gly Glu Asp Ala Thr Pro Gly Thr Gly Tyr Thr Gly Leu Ala 
        115                 120                 125             


Ala Ile Gln Leu Pro Lys Lys Ala Gly Asp Ile Thr Asn Lys Ala Thr 
    130                 135                 140                 


Lys Glu Lys Glu Ser Asp Glu Glu Glu Glu Glu Glu Glu Glu Gly Asn 
145                 150                 155                 160 


Glu Asn Glu Glu Ser Glu Ala Glu Val Asp Glu Asn Glu Gln Gly Ile 
                165                 170                 175     


Asn Gly Thr Ser Thr Asn Ser Thr Glu Ala Glu Asn Gly Asn Gly Ser 
            180                 185                 190         


Ser Gly Gly Asp Asn Gly Glu Glu Gly Glu Glu Glu Ser Val Thr Gly 
        195                 200                 205             


Ala Asn Ala Glu Asp Thr Thr Glu Thr Gly Arg Gln Gly Lys Gly Thr 
    210                 215                 220                 


Ser Lys Thr Thr Thr Ser Pro Asn Gly Gly Phe Glu Pro Thr Thr Pro 
225                 230                 235                 240 


Pro Gln Val Tyr Arg Thr Thr Ser Pro Pro Phe Gly Lys Thr Thr Thr 
                245                 250                 255     


Val Glu Tyr Glu Gly Glu Tyr Glu Tyr Thr Gly Ala Asn Glu Tyr Asp 
            260                 265                 270         


Asn Gly Tyr Glu Ile Tyr Glu Ser Glu Asn Gly Glu Pro Arg Gly Asp 
        275                 280                 285             


Asn Tyr Arg Ala Tyr Glu Asp Glu Tyr Ser Tyr Phe Lys Gly Gln Gly 
    290                 295                 300                 


Tyr Asp Gly Tyr Asp Gly Gln Asn Tyr Tyr His His Gln 
305                 310                 315         


<210>  491
<211>  2345
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (209)..(685)

<400>  491
aaagcaggcg gggcgttgga gttcagatgt tcgctcccgg gataggctgc cccggagagg       60

gagaggcggg gtcggctgta tcacgtggat ctgctcccgc cgccgccgcc gccgccgtcg      120

tctttctctg tctcggctga ggcagccatc tttctcttgc cgcgtgctgg tgttggagga      180

ccctccctgc ttcagattta ccaacagc atg aat caa gaa aag tta gcc aaa         232
                               Met Asn Gln Glu Lys Leu Ala Lys            
                               1               5                          

ctt cag gct cag gtc cgg ata ggg ggc aag ggt aca gct cgc aga aag        280
Leu Gln Ala Gln Val Arg Ile Gly Gly Lys Gly Thr Ala Arg Arg Lys           
    10                  15                  20                            

aag aag gtg gta cat aga aca gcc aca gct gat gac aaa aag ctt cag        328
Lys Lys Val Val His Arg Thr Ala Thr Ala Asp Asp Lys Lys Leu Gln           
25                  30                  35                  40            

agt tct cta aaa aaa ctg gct gtg aat aat ata gct ggt att gaa gag        376
Ser Ser Leu Lys Lys Leu Ala Val Asn Asn Ile Ala Gly Ile Glu Glu           
                45                  50                  55                

gtg aac atg att aaa gat gat ggg aca gtt att cat ttc aac aat ccc        424
Val Asn Met Ile Lys Asp Asp Gly Thr Val Ile His Phe Asn Asn Pro           
            60                  65                  70                    

aaa gtc caa gct tcc ctt tct gct aat acc ttt gca att act ggt cat        472
Lys Val Gln Ala Ser Leu Ser Ala Asn Thr Phe Ala Ile Thr Gly His           
        75                  80                  85                        

gca gaa gcc aaa cca atc aca gaa atg ctt cct gga ata tta agt cag        520
Ala Glu Ala Lys Pro Ile Thr Glu Met Leu Pro Gly Ile Leu Ser Gln           
    90                  95                  100                           

ctt ggt gct gac agt tta aca agc ctt agg aag tta gct gaa cag ttc        568
Leu Gly Ala Asp Ser Leu Thr Ser Leu Arg Lys Leu Ala Glu Gln Phe           
105                 110                 115                 120           

cca cgg caa gtc ttg gac agt aaa gca cca aaa cca gaa gac att gat        616
Pro Arg Gln Val Leu Asp Ser Lys Ala Pro Lys Pro Glu Asp Ile Asp           
                125                 130                 135               

gag gaa gat gat gat gtt cca gat ctt gta gaa aat ttt gat gag gca        664
Glu Glu Asp Asp Asp Val Pro Asp Leu Val Glu Asn Phe Asp Glu Ala           
            140                 145                 150                   

tca aag aat gaa gct aac taa aagtttggtt tttggaagct ggcatggact           715
Ser Lys Asn Glu Ala Asn                                                   
        155                                                               

agatttaaca aatcagctat gtggttccaa agttttacag acatggagaa catcacctgt      775

tactagttca gtaatataaa tattttgtat attaataatg ctgtttgttc agcatttttc      835

ggtcatttga ttttgcattt tgcacttcct cccaggatat ttttttggtc aaaatatgaa      895

gtattggtgc agtttgaggg tgttttggtt tttgattcct ggtttttttg ttttttgttt      955

ggggtatttt tggtgtatgt atgtttatgt atgtgtgtgg gtatgtgtgt atacagtgga     1015

gagcaaattg gaaaacagtt ctatttatcc tcctccctcc ccagtagaaa taaaaaaaat     1075

ctttacattt gttacttttc ttttcccccc gtaagacaca gaattaatgg aaagtgagta     1135

tcttggattt caaatctgaa gagattttta ccattagtgg tttgatttta atttgcttgg     1195

ttaactatca tatttttcat acacttctct ggatttaaaa tatcttgagg tattttgcca     1255

ctggcttcat gctggagtaa tgggtaacat atctttggta tggttgcctt agattaactt     1315

acctagtcag acccagaaga acttctttta ctagcttgct tcctaaatgc cttttttcct     1375

ctccttttgg tctccaaatg gcctggtcag cttttggtaa tattcttcct catcttccac     1435

ctagcttgag aaggatgttc tccatataga gtttagcgag tgcctaatcc ctccttttgt     1495

aagattttgt tccctcagct tgaggaacaa cttcatcttc aactttttat ttctccctga     1555

tgttacagtt tggtagattt caaactggaa tagctagcat gtgcttgcta aataatttta     1615

tgccagcctt atcctgtatc ctagctgttc ttaacagcag gtacaaaaat gcctgttttt     1675

cagcaaggtt gaaattggga atgtcctttt gaatcagaag aaaataggcc atagactcat     1735

ctcccagcac aaatgggcat tctatgaaat ggtactggcc ctaggaggat ttcctcaacc     1795

actctcctac tcttggcctt gaacctacct ctgggttgga tcttactatt gtagctgctc     1855

actataccct cctgcatgct tagaataatg ctttgagggg agcactggta aaacacagta     1915

tttatttttt tacctccttt aagaggactt ggaggtaagt tgcattcatt cactcaagtt     1975

tccctcttgc tgtctaatag aagcttactt tttgctatat cagcatttgt tacagccaat     2035

atttaaggac aaaatttaga aaatatatca tttcctggcc catcatcaaa ctaatacagc     2095

ttaaccttgc agctaccaac ttttgtgtca agctagatat ctttatttga tatctaaggt     2155

gcaagaccaa caatatatta agagatctgt agacatgaag gcaaagctct tgtatttttt     2215

ttcatccaaa cacctcaatt tattttataa attcgttcat ttttcctgtt atgttttata     2275

taatatatgg actaaacaaa ataaaataac agtgcaaaag aggagaatat ttcctcttgt     2335

gcttttcttg                                                            2345


<210>  492
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  492

Met Asn Gln Glu Lys Leu Ala Lys Leu Gln Ala Gln Val Arg Ile Gly 
1               5                   10                  15      


Gly Lys Gly Thr Ala Arg Arg Lys Lys Lys Val Val His Arg Thr Ala 
            20                  25                  30          


Thr Ala Asp Asp Lys Lys Leu Gln Ser Ser Leu Lys Lys Leu Ala Val 
        35                  40                  45              


Asn Asn Ile Ala Gly Ile Glu Glu Val Asn Met Ile Lys Asp Asp Gly 
    50                  55                  60                  


Thr Val Ile His Phe Asn Asn Pro Lys Val Gln Ala Ser Leu Ser Ala 
65                  70                  75                  80  


Asn Thr Phe Ala Ile Thr Gly His Ala Glu Ala Lys Pro Ile Thr Glu 
                85                  90                  95      


Met Leu Pro Gly Ile Leu Ser Gln Leu Gly Ala Asp Ser Leu Thr Ser 
            100                 105                 110         


Leu Arg Lys Leu Ala Glu Gln Phe Pro Arg Gln Val Leu Asp Ser Lys 
        115                 120                 125             


Ala Pro Lys Pro Glu Asp Ile Asp Glu Glu Asp Asp Asp Val Pro Asp 
    130                 135                 140                 


Leu Val Glu Asn Phe Asp Glu Ala Ser Lys Asn Glu Ala Asn 
145                 150                 155             


<210>  493
<211>  918
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (27)..(842)

<400>  493
ccagctcacg tcttccccac cccagc atg gcc gcg tgc acc atg tcc gtc tgc        53
                             Met Ala Ala Cys Thr Met Ser Val Cys          
                             1               5                            

tcc agc gct tgc tct gac tcc tgg cga gtg gac gac tgc cca gag agc        101
Ser Ser Ala Cys Ser Asp Ser Trp Arg Val Asp Asp Cys Pro Glu Ser           
10                  15                  20                  25            

tgc tgt gag ccc ccc tgc ggc acc gcc ccc tgc ctg acc ctg gtc tgc        149
Cys Cys Glu Pro Pro Cys Gly Thr Ala Pro Cys Leu Thr Leu Val Cys           
                30                  35                  40                

acc cca gtg agc tgt gtg tcc agc ccc tgc tgc cag gcg gcc tgt gag        197
Thr Pro Val Ser Cys Val Ser Ser Pro Cys Cys Gln Ala Ala Cys Glu           
            45                  50                  55                    

ccc agc ccc tgc caa tca ggc tgc acc agc tcc tgc acg ccc tcg tgc        245
Pro Ser Pro Cys Gln Ser Gly Cys Thr Ser Ser Cys Thr Pro Ser Cys           
        60                  65                  70                        

tgc cag ccg gct tgc tgc gcc tcc tcc ccc tgc cag cag gcc tgc tgc        293
Cys Gln Pro Ala Cys Cys Ala Ser Ser Pro Cys Gln Gln Ala Cys Cys           
    75                  80                  85                            

gtg ccc gtc tgc tgc aag cct gtg tgc tgc ctg ccc acc tgc tct aag        341
Val Pro Val Cys Cys Lys Pro Val Cys Cys Leu Pro Thr Cys Ser Lys           
90                  95                  100                 105           

gat tcc tct tca tgc tgc cag cag tct agc tgc cag cca act tgc tgt        389
Asp Ser Ser Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Thr Cys Cys           
                110                 115                 120               

gcc tct tcc tcc tgc cag cag tcc tgc tgt gtg cct gtc tgc tgc aag        437
Ala Ser Ser Ser Cys Gln Gln Ser Cys Cys Val Pro Val Cys Cys Lys           
            125                 130                 135                   

ccc gtg tgc tgt gtg ccc acc tgt tct gag gat tcc tct tca tgc tgc        485
Pro Val Cys Cys Val Pro Thr Cys Ser Glu Asp Ser Ser Ser Cys Cys           
        140                 145                 150                       

cag cat tct agc tgc cag ccg act tgc tgc acc tcc tcc ccc tgc cag        533
Gln His Ser Ser Cys Gln Pro Thr Cys Cys Thr Ser Ser Pro Cys Gln           
    155                 160                 165                           

cag tcc tgc tac gtg cct gtc tgt tgc aag cct gtc tgc ttc aaa ccc        581
Gln Ser Cys Tyr Val Pro Val Cys Cys Lys Pro Val Cys Phe Lys Pro           
170                 175                 180                 185           

atc tgc tgt gtg ccc gtc tgc tct ggg gct tcc act tca tgc tgc cag        629
Ile Cys Cys Val Pro Val Cys Ser Gly Ala Ser Thr Ser Cys Cys Gln           
                190                 195                 200               

cag tct agc tgt cag ccg gct tgc tgc acc acc tcc tgc tgc aga ccc        677
Gln Ser Ser Cys Gln Pro Ala Cys Cys Thr Thr Ser Cys Cys Arg Pro           
            205                 210                 215                   

tcc tcc tcc gtg tcc ctc ctc tgc cgc ccc ata tgc agg ccc gcc tgc        725
Ser Ser Ser Val Ser Leu Leu Cys Arg Pro Ile Cys Arg Pro Ala Cys           
        220                 225                 230                       

tgc gtg ccc atc tcc tcc tgc tgt gcc cct gcc tcc tcc tac cag gcc        773
Cys Val Pro Ile Ser Ser Cys Cys Ala Pro Ala Ser Ser Tyr Gln Ala           
    235                 240                 245                           

agc tgc tgc cgc ccg gcc tcc tgc gtg tcc ctc ctc tgc cgc ccc gcg        821
Ser Cys Cys Arg Pro Ala Ser Cys Val Ser Leu Leu Cys Arg Pro Ala           
250                 255                 260                 265           

tgc tcc cgc ctg gcc tgc tga ggcctctgct caggccagga gtccagttgc           872
Cys Ser Arg Leu Ala Cys                                                   
                270                                                       

tgatgtgcac atcccccagg gccaactggt cctgactcgg gttagg                     918


<210>  494
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  494

Met Ala Ala Cys Thr Met Ser Val Cys Ser Ser Ala Cys Ser Asp Ser 
1               5                   10                  15      


Trp Arg Val Asp Asp Cys Pro Glu Ser Cys Cys Glu Pro Pro Cys Gly 
            20                  25                  30          


Thr Ala Pro Cys Leu Thr Leu Val Cys Thr Pro Val Ser Cys Val Ser 
        35                  40                  45              


Ser Pro Cys Cys Gln Ala Ala Cys Glu Pro Ser Pro Cys Gln Ser Gly 
    50                  55                  60                  


Cys Thr Ser Ser Cys Thr Pro Ser Cys Cys Gln Pro Ala Cys Cys Ala 
65                  70                  75                  80  


Ser Ser Pro Cys Gln Gln Ala Cys Cys Val Pro Val Cys Cys Lys Pro 
                85                  90                  95      


Val Cys Cys Leu Pro Thr Cys Ser Lys Asp Ser Ser Ser Cys Cys Gln 
            100                 105                 110         


Gln Ser Ser Cys Gln Pro Thr Cys Cys Ala Ser Ser Ser Cys Gln Gln 
        115                 120                 125             


Ser Cys Cys Val Pro Val Cys Cys Lys Pro Val Cys Cys Val Pro Thr 
    130                 135                 140                 


Cys Ser Glu Asp Ser Ser Ser Cys Cys Gln His Ser Ser Cys Gln Pro 
145                 150                 155                 160 


Thr Cys Cys Thr Ser Ser Pro Cys Gln Gln Ser Cys Tyr Val Pro Val 
                165                 170                 175     


Cys Cys Lys Pro Val Cys Phe Lys Pro Ile Cys Cys Val Pro Val Cys 
            180                 185                 190         


Ser Gly Ala Ser Thr Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala 
        195                 200                 205             


Cys Cys Thr Thr Ser Cys Cys Arg Pro Ser Ser Ser Val Ser Leu Leu 
    210                 215                 220                 


Cys Arg Pro Ile Cys Arg Pro Ala Cys Cys Val Pro Ile Ser Ser Cys 
225                 230                 235                 240 


Cys Ala Pro Ala Ser Ser Tyr Gln Ala Ser Cys Cys Arg Pro Ala Ser 
                245                 250                 255     


Cys Val Ser Leu Leu Cys Arg Pro Ala Cys Ser Arg Leu Ala Cys 
            260                 265                 270     


<210>  495
<211>  4071
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (4)..(2457)

<400>  495
acc atg atg aag acg gag cca cgg ggg ccc ggg ggt ccc ctc cgg agc         48
    Met Met Lys Thr Glu Pro Arg Gly Pro Gly Gly Pro Leu Arg Ser           
    1               5                   10                  15            

gcc tcc ccg cac cgc agc gcc tac gag gcg ggc atc cag gcg ctg aag         96
Ala Ser Pro His Arg Ser Ala Tyr Glu Ala Gly Ile Gln Ala Leu Lys           
                20                  25                  30                

ccg ccc gac gcg ccc ggg ccc gac gag gca ccc aag ggg gcc cac cac        144
Pro Pro Asp Ala Pro Gly Pro Asp Glu Ala Pro Lys Gly Ala His His           
            35                  40                  45                    

aag aaa tat ggc tcc aac gtc cac cgc atc aaa agt atg ttc ctg cag        192
Lys Lys Tyr Gly Ser Asn Val His Arg Ile Lys Ser Met Phe Leu Gln           
        50                  55                  60                        

atg ggc acg acg gcg ggg ccc tcg ggc gag gcg ggc ggc ggc gcg ggc        240
Met Gly Thr Thr Ala Gly Pro Ser Gly Glu Ala Gly Gly Gly Ala Gly           
    65                  70                  75                            

ctg gcc gag gcc cca cgg gcg tcc gag cgc ggc gtg cgc ctg tcg ctg        288
Leu Ala Glu Ala Pro Arg Ala Ser Glu Arg Gly Val Arg Leu Ser Leu           
80                  85                  90                  95            

ccg cgg gcc agc agc ctg aac gag aac gtg gac cac agc gcc ctg ctg        336
Pro Arg Ala Ser Ser Leu Asn Glu Asn Val Asp His Ser Ala Leu Leu           
                100                 105                 110               

aag ctg ggc acc agc gtg tcg gag cgc gtg agc cgc ttc gac tcc aag        384
Lys Leu Gly Thr Ser Val Ser Glu Arg Val Ser Arg Phe Asp Ser Lys           
            115                 120                 125                   

ccc gcg ccc tcc gcg cag cct gcg ccg ccg ccg cac ccg ccg tcc cgg        432
Pro Ala Pro Ser Ala Gln Pro Ala Pro Pro Pro His Pro Pro Ser Arg           
        130                 135                 140                       

ctg cag gag acg cgg aag ctg ttc gaa cgg agc gcc cca gcg gcc gca        480
Leu Gln Glu Thr Arg Lys Leu Phe Glu Arg Ser Ala Pro Ala Ala Ala           
    145                 150                 155                           

ggc ggc gac aag gag gcc gcg gcg cgg cgg ctg ctg agg cag gag cgc        528
Gly Gly Asp Lys Glu Ala Ala Ala Arg Arg Leu Leu Arg Gln Glu Arg           
160                 165                 170                 175           

gcc ggc ctg cag gac cgg aag ctg gac gtc gtg gtg cgc ttc aac ggc        576
Ala Gly Leu Gln Asp Arg Lys Leu Asp Val Val Val Arg Phe Asn Gly           
                180                 185                 190               

agc acc gag gcg ctg gac aag ctg gac gct gac gcc gtg tcc ccc acg        624
Ser Thr Glu Ala Leu Asp Lys Leu Asp Ala Asp Ala Val Ser Pro Thr           
            195                 200                 205                   

gtc agc cag ctc agc gcc gtc ttc gag aag gcc gac tcg agg acc ggc        672
Val Ser Gln Leu Ser Ala Val Phe Glu Lys Ala Asp Ser Arg Thr Gly           
        210                 215                 220                       

ctc cac cgc ggg ccc ggg ctc ccc agg gcc gca ggg gtt ccc cag gtc        720
Leu His Arg Gly Pro Gly Leu Pro Arg Ala Ala Gly Val Pro Gln Val           
    225                 230                 235                           

aac tcg aag ctg gtc agc aag cgg tcc cgg gtg ttc cag ccc ccg ccg        768
Asn Ser Lys Leu Val Ser Lys Arg Ser Arg Val Phe Gln Pro Pro Pro           
240                 245                 250                 255           

ccg ccg ccg ccc gcc ccg tcg ggg gat gcc ccg gcc gag aaa gag cga        816
Pro Pro Pro Pro Ala Pro Ser Gly Asp Ala Pro Ala Glu Lys Glu Arg           
                260                 265                 270               

tgc ccc gca ggg cag cag ccc ccg cag cac cga gtg gcc cct gcc cgg        864
Cys Pro Ala Gly Gln Gln Pro Pro Gln His Arg Val Ala Pro Ala Arg           
            275                 280                 285                   

ccg ccc ccc aag ccc cgg gag gtg cgc aag att aag ccg gtg gag gtg        912
Pro Pro Pro Lys Pro Arg Glu Val Arg Lys Ile Lys Pro Val Glu Val           
        290                 295                 300                       

gag gag agc ggg gag tcg gag gcc gag tcg gcg ccc ggg gag gtg atc        960
Glu Glu Ser Gly Glu Ser Glu Ala Glu Ser Ala Pro Gly Glu Val Ile           
    305                 310                 315                           

cag gcc gag gtt acg gtc cac gcg gcc ctg gag aat ggc agc acc gtg       1008
Gln Ala Glu Val Thr Val His Ala Ala Leu Glu Asn Gly Ser Thr Val           
320                 325                 330                 335           

gca act gca gcc agc ccc gcg ccc gag gag cca aag gcc caa gcg gcc       1056
Ala Thr Ala Ala Ser Pro Ala Pro Glu Glu Pro Lys Ala Gln Ala Ala           
                340                 345                 350               

ccg gag aag gag gcg gcg gcg gta gcg ccg cca gag agg ggg gtg ggc       1104
Pro Glu Lys Glu Ala Ala Ala Val Ala Pro Pro Glu Arg Gly Val Gly           
            355                 360                 365                   

aat ggc cgg gcc ccg gac gtg gcc cct gag gag gta gat gaa tcc aag       1152
Asn Gly Arg Ala Pro Asp Val Ala Pro Glu Glu Val Asp Glu Ser Lys           
        370                 375                 380                       

aag gag gac ttc tcg gag gcg gac ttg gtg gac gtg agc gcc tac agt       1200
Lys Glu Asp Phe Ser Glu Ala Asp Leu Val Asp Val Ser Ala Tyr Ser           
    385                 390                 395                           

ggg ctc ggg gag gac tct gcg ggc agt gcc ctg gag gag gac gac gaa       1248
Gly Leu Gly Glu Asp Ser Ala Gly Ser Ala Leu Glu Glu Asp Asp Glu           
400                 405                 410                 415           

gac gac gag gag gat ggg gag ccc ccc tac gag ccc gag tcg ggg tgc       1296
Asp Asp Glu Glu Asp Gly Glu Pro Pro Tyr Glu Pro Glu Ser Gly Cys           
                420                 425                 430               

gtg gag atc ccg ggg ctg tcg gag gag gag gac cca gcc ccg agc cgg       1344
Val Glu Ile Pro Gly Leu Ser Glu Glu Glu Asp Pro Ala Pro Ser Arg           
            435                 440                 445                   

aag atc cat ttc agc acg gcg ccc atc caa gtg ttc agc act tac tcc       1392
Lys Ile His Phe Ser Thr Ala Pro Ile Gln Val Phe Ser Thr Tyr Ser           
        450                 455                 460                       

aac gag gat tac gat cgt cgc aac gag gat gtg gat ccc atg gca gcc       1440
Asn Glu Asp Tyr Asp Arg Arg Asn Glu Asp Val Asp Pro Met Ala Ala           
    465                 470                 475                           

tct gct gag tac gag ctg gag aag cgt gtg gag agg ttg gag ctg ttc       1488
Ser Ala Glu Tyr Glu Leu Glu Lys Arg Val Glu Arg Leu Glu Leu Phe           
480                 485                 490                 495           

cct gtg gag ctg gag aag gac tcc gag ggc ctg ggc atc agc atc atc       1536
Pro Val Glu Leu Glu Lys Asp Ser Glu Gly Leu Gly Ile Ser Ile Ile           
                500                 505                 510               

ggc atg ggc gcc ggg gca gac atg ggc ctg gag aag ctg ggt atc ttc       1584
Gly Met Gly Ala Gly Ala Asp Met Gly Leu Glu Lys Leu Gly Ile Phe           
            515                 520                 525                   

gtc aag acc gtg acg gag ggt ggt gcg gcc cat cgg gat ggc agg atc       1632
Val Lys Thr Val Thr Glu Gly Gly Ala Ala His Arg Asp Gly Arg Ile           
        530                 535                 540                       

cag gtg aat gat ctc ctg gtg gag gtg gat gga aca agt ctg gtg gga       1680
Gln Val Asn Asp Leu Leu Val Glu Val Asp Gly Thr Ser Leu Val Gly           
    545                 550                 555                           

gtg acc cag agc ttc gcg gcg tct gtg ctc cgg aac acc aag ggc cga       1728
Val Thr Gln Ser Phe Ala Ala Ser Val Leu Arg Asn Thr Lys Gly Arg           
560                 565                 570                 575           

gtg cgg ttt atg att ggc cgg gag cgg ccg gga gag cag agc gaa gtg       1776
Val Arg Phe Met Ile Gly Arg Glu Arg Pro Gly Glu Gln Ser Glu Val           
                580                 585                 590               

gcc cag cta att cag cag act ttg gaa cag gag cga tgg cag cgg gag       1824
Ala Gln Leu Ile Gln Gln Thr Leu Glu Gln Glu Arg Trp Gln Arg Glu           
            595                 600                 605                   

atg atg gag cag aga tac gcc cag tat ggg gag gat gac gag gag acg       1872
Met Met Glu Gln Arg Tyr Ala Gln Tyr Gly Glu Asp Asp Glu Glu Thr           
        610                 615                 620                       

gga gag tat gcc act gac gag gat gag gag ctg agc ccc acg ttc ccg       1920
Gly Glu Tyr Ala Thr Asp Glu Asp Glu Glu Leu Ser Pro Thr Phe Pro           
    625                 630                 635                           

ggt ggt gag atg gcc atc gag gtg ttt gag cta gcg gag aac gag gat       1968
Gly Gly Glu Met Ala Ile Glu Val Phe Glu Leu Ala Glu Asn Glu Asp           
640                 645                 650                 655           

gca ctg tcc cct gtg gac atg gag ccc gag aag ctg gtg cac aag ttc       2016
Ala Leu Ser Pro Val Asp Met Glu Pro Glu Lys Leu Val His Lys Phe           
                660                 665                 670               

aag gag ctc cag atc aag cat gcg gtc act gag gca gag atc cag cag       2064
Lys Glu Leu Gln Ile Lys His Ala Val Thr Glu Ala Glu Ile Gln Gln           
            675                 680                 685                   

ctg aaa aga aag ctg cag agc ctg gag cag gag aag ggg cgc tgg cgg       2112
Leu Lys Arg Lys Leu Gln Ser Leu Glu Gln Glu Lys Gly Arg Trp Arg           
        690                 695                 700                       

gtg gag aag gcg cag ttg gag cag agt gtg gag gag aac aag gag cgc       2160
Val Glu Lys Ala Gln Leu Glu Gln Ser Val Glu Glu Asn Lys Glu Arg           
    705                 710                 715                           

atg gag aaa ctg gaa ggc tac tgg ggt gag gcc cag agc ctg tgc cag       2208
Met Glu Lys Leu Glu Gly Tyr Trp Gly Glu Ala Gln Ser Leu Cys Gln           
720                 725                 730                 735           

gct gtg gac gag cac ctg cgg gag act cag gcg cag tac cag gcc ctg       2256
Ala Val Asp Glu His Leu Arg Glu Thr Gln Ala Gln Tyr Gln Ala Leu           
                740                 745                 750               

gag cgc aag tac agc aag gcc aag cgc ctc atc aag gac tac cag cag       2304
Glu Arg Lys Tyr Ser Lys Ala Lys Arg Leu Ile Lys Asp Tyr Gln Gln           
            755                 760                 765                   

aag gag atc gag ttc ctg aaa aag gag act gca cag cgt cgg gtt ctg       2352
Lys Glu Ile Glu Phe Leu Lys Lys Glu Thr Ala Gln Arg Arg Val Leu           
        770                 775                 780                       

gag gag tcg gag ctg gcc aga aag gag gag atg gac aag ctc ctg gac       2400
Glu Glu Ser Glu Leu Ala Arg Lys Glu Glu Met Asp Lys Leu Leu Asp           
    785                 790                 795                           

aag atc tca gaa ctg gaa gga aac ttg caa aca ctg agg aat tcc aat       2448
Lys Ile Ser Glu Leu Glu Gly Asn Leu Gln Thr Leu Arg Asn Ser Asn           
800                 805                 810                 815           

tct act taa caggaatcat tccatgactg gacaataatt aacccccctc               2497
Ser Thr                                                                   
                                                                          

ccattgtcct ccctcccctg tcctcaacac cccacccctc ccccttccag cctggggaca     2557

ggtgccccga ctccccccac ccctccaccc cacctccccc agcttcaggg accagagggc     2617

tcatatcaca ggccccctta agatggcctg ggcagacaga ggtggctaga agggcagcct     2677

ctttcttgcc ccatggggct gaggcacaga ggccgagggc tgccgagggc tggcctggtg     2737

gtcgacggac acaagcacct gcagatcaaa ctgccagact ttacacactc cagcttttgt     2797

ctctggactg gaacggggct ggggctctcc cagcatctgc caactggggg ctgctccctg     2857

cccatggggc acctgggtgg cccctgggcc tcttgacttg agattctacc ttctcggccc     2917

ttccctctcc ccccatcatt gtgccgtctc tgttgcattc tgaccctccc gcctgggggg     2977

tgggggcgtt gcctcaacac ctcccccatc cctgttccct gtcctgggag ggatagagtc     3037

caccccagag cccggaggct gggcctggcc ctggccctgc actgatttct catgtgtcct     3097

tcgggaaaag ggggagtgag agtgggaaaa agggagagtt caggacacct ggtccccagc     3157

tccccattgc ctggggcagc agccctcaat ttctccttgt gcctcccctc ttccaggtgc     3217

caaatagcca taacctcgtc ttggaactgt tatgtggcct ctctggggtc caggtttcct     3277

ggtcaagcct gggaatgcca gggaggaaag ggggtctggc tacagcgacc ctggtcttag     3337

gcaaggggaa catttctccc tggagagtca ggtcctatcc tgtgctgccc tgtctgccca     3397

gcccagggcg atgcctggaa gcctactgac attgcaggga gtcagcctcg cccccacccc     3457

ctactggttt tccaatgttt tgactggagg gcaaaatttt actactactc atctttttgg     3517

agaccagggc tgccctgctg gcagcctgcc ttctaagtga aatcgactct gtttccccac     3577

tttaacccca aattggggct tggaccaagg gaggtgagac cacctccccc aggtcccctc     3637

ccctttcaaa atccatctca ttttgccact tcatgcccct gccctaactg ggtttttgtt     3697

cattttttaa aaacagacca cccatcccat ccgttttggc ttcttgtccc ctgtaaatag     3757

accatgactt cgatcagtat ttcttgtccc caccccttcc tatccccaga tgtgccccca     3817

tcccctgaag gagctggctg tctcagtcct gggctcgcgc acttcacccc ggcagatgga     3877

gggggcggaa ccgggtgggc ggggccgctt cgggctgctt gggccagcgg ccacccctgc     3937

ccagccgtcg ggagggccgc atctctgtat ataatatata tatgtatgta ttgttcccgg     3997

ttttgtacgg accatgccct ctgtcaggtc gtccccataa aagcagcccc cagaaaaaaa     4057

aaaaaaaaaa aaaa                                                       4071


<210>  496
<211>  817
<212>  PRT
<213>  Homo sapiens

<400>  496

Met Met Lys Thr Glu Pro Arg Gly Pro Gly Gly Pro Leu Arg Ser Ala 
1               5                   10                  15      


Ser Pro His Arg Ser Ala Tyr Glu Ala Gly Ile Gln Ala Leu Lys Pro 
            20                  25                  30          


Pro Asp Ala Pro Gly Pro Asp Glu Ala Pro Lys Gly Ala His His Lys 
        35                  40                  45              


Lys Tyr Gly Ser Asn Val His Arg Ile Lys Ser Met Phe Leu Gln Met 
    50                  55                  60                  


Gly Thr Thr Ala Gly Pro Ser Gly Glu Ala Gly Gly Gly Ala Gly Leu 
65                  70                  75                  80  


Ala Glu Ala Pro Arg Ala Ser Glu Arg Gly Val Arg Leu Ser Leu Pro 
                85                  90                  95      


Arg Ala Ser Ser Leu Asn Glu Asn Val Asp His Ser Ala Leu Leu Lys 
            100                 105                 110         


Leu Gly Thr Ser Val Ser Glu Arg Val Ser Arg Phe Asp Ser Lys Pro 
        115                 120                 125             


Ala Pro Ser Ala Gln Pro Ala Pro Pro Pro His Pro Pro Ser Arg Leu 
    130                 135                 140                 


Gln Glu Thr Arg Lys Leu Phe Glu Arg Ser Ala Pro Ala Ala Ala Gly 
145                 150                 155                 160 


Gly Asp Lys Glu Ala Ala Ala Arg Arg Leu Leu Arg Gln Glu Arg Ala 
                165                 170                 175     


Gly Leu Gln Asp Arg Lys Leu Asp Val Val Val Arg Phe Asn Gly Ser 
            180                 185                 190         


Thr Glu Ala Leu Asp Lys Leu Asp Ala Asp Ala Val Ser Pro Thr Val 
        195                 200                 205             


Ser Gln Leu Ser Ala Val Phe Glu Lys Ala Asp Ser Arg Thr Gly Leu 
    210                 215                 220                 


His Arg Gly Pro Gly Leu Pro Arg Ala Ala Gly Val Pro Gln Val Asn 
225                 230                 235                 240 


Ser Lys Leu Val Ser Lys Arg Ser Arg Val Phe Gln Pro Pro Pro Pro 
                245                 250                 255     


Pro Pro Pro Ala Pro Ser Gly Asp Ala Pro Ala Glu Lys Glu Arg Cys 
            260                 265                 270         


Pro Ala Gly Gln Gln Pro Pro Gln His Arg Val Ala Pro Ala Arg Pro 
        275                 280                 285             


Pro Pro Lys Pro Arg Glu Val Arg Lys Ile Lys Pro Val Glu Val Glu 
    290                 295                 300                 


Glu Ser Gly Glu Ser Glu Ala Glu Ser Ala Pro Gly Glu Val Ile Gln 
305                 310                 315                 320 


Ala Glu Val Thr Val His Ala Ala Leu Glu Asn Gly Ser Thr Val Ala 
                325                 330                 335     


Thr Ala Ala Ser Pro Ala Pro Glu Glu Pro Lys Ala Gln Ala Ala Pro 
            340                 345                 350         


Glu Lys Glu Ala Ala Ala Val Ala Pro Pro Glu Arg Gly Val Gly Asn 
        355                 360                 365             


Gly Arg Ala Pro Asp Val Ala Pro Glu Glu Val Asp Glu Ser Lys Lys 
    370                 375                 380                 


Glu Asp Phe Ser Glu Ala Asp Leu Val Asp Val Ser Ala Tyr Ser Gly 
385                 390                 395                 400 


Leu Gly Glu Asp Ser Ala Gly Ser Ala Leu Glu Glu Asp Asp Glu Asp 
                405                 410                 415     


Asp Glu Glu Asp Gly Glu Pro Pro Tyr Glu Pro Glu Ser Gly Cys Val 
            420                 425                 430         


Glu Ile Pro Gly Leu Ser Glu Glu Glu Asp Pro Ala Pro Ser Arg Lys 
        435                 440                 445             


Ile His Phe Ser Thr Ala Pro Ile Gln Val Phe Ser Thr Tyr Ser Asn 
    450                 455                 460                 


Glu Asp Tyr Asp Arg Arg Asn Glu Asp Val Asp Pro Met Ala Ala Ser 
465                 470                 475                 480 


Ala Glu Tyr Glu Leu Glu Lys Arg Val Glu Arg Leu Glu Leu Phe Pro 
                485                 490                 495     


Val Glu Leu Glu Lys Asp Ser Glu Gly Leu Gly Ile Ser Ile Ile Gly 
            500                 505                 510         


Met Gly Ala Gly Ala Asp Met Gly Leu Glu Lys Leu Gly Ile Phe Val 
        515                 520                 525             


Lys Thr Val Thr Glu Gly Gly Ala Ala His Arg Asp Gly Arg Ile Gln 
    530                 535                 540                 


Val Asn Asp Leu Leu Val Glu Val Asp Gly Thr Ser Leu Val Gly Val 
545                 550                 555                 560 


Thr Gln Ser Phe Ala Ala Ser Val Leu Arg Asn Thr Lys Gly Arg Val 
                565                 570                 575     


Arg Phe Met Ile Gly Arg Glu Arg Pro Gly Glu Gln Ser Glu Val Ala 
            580                 585                 590         


Gln Leu Ile Gln Gln Thr Leu Glu Gln Glu Arg Trp Gln Arg Glu Met 
        595                 600                 605             


Met Glu Gln Arg Tyr Ala Gln Tyr Gly Glu Asp Asp Glu Glu Thr Gly 
    610                 615                 620                 


Glu Tyr Ala Thr Asp Glu Asp Glu Glu Leu Ser Pro Thr Phe Pro Gly 
625                 630                 635                 640 


Gly Glu Met Ala Ile Glu Val Phe Glu Leu Ala Glu Asn Glu Asp Ala 
                645                 650                 655     


Leu Ser Pro Val Asp Met Glu Pro Glu Lys Leu Val His Lys Phe Lys 
            660                 665                 670         


Glu Leu Gln Ile Lys His Ala Val Thr Glu Ala Glu Ile Gln Gln Leu 
        675                 680                 685             


Lys Arg Lys Leu Gln Ser Leu Glu Gln Glu Lys Gly Arg Trp Arg Val 
    690                 695                 700                 


Glu Lys Ala Gln Leu Glu Gln Ser Val Glu Glu Asn Lys Glu Arg Met 
705                 710                 715                 720 


Glu Lys Leu Glu Gly Tyr Trp Gly Glu Ala Gln Ser Leu Cys Gln Ala 
                725                 730                 735     


Val Asp Glu His Leu Arg Glu Thr Gln Ala Gln Tyr Gln Ala Leu Glu 
            740                 745                 750         


Arg Lys Tyr Ser Lys Ala Lys Arg Leu Ile Lys Asp Tyr Gln Gln Lys 
        755                 760                 765             


Glu Ile Glu Phe Leu Lys Lys Glu Thr Ala Gln Arg Arg Val Leu Glu 
    770                 775                 780                 


Glu Ser Glu Leu Ala Arg Lys Glu Glu Met Asp Lys Leu Leu Asp Lys 
785                 790                 795                 800 


Ile Ser Glu Leu Glu Gly Asn Leu Gln Thr Leu Arg Asn Ser Asn Ser 
                805                 810                 815     


Thr 
    


<210>  497
<211>  2136
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (472)..(975)

<400>  497
aagacattca tcctcccgga ggcccgcgcc gccctcgccc tgcacgccta gcgttgtccc       60

gcggccaggc ccggccggag cggcggcgcc tggatgtgga cctggctgcg gggagacggg      120

cgccggcccc aaagcgactt tcggtcctcg acgcgccccg ccccacccct gcgatgaaga      180

gggcgtctgc tggaggttcc aggccccgat tcccttatcc tgggggacga cagcatccat      240

agcctggact ttgtgtcgag ccgagcctgg acttccctga ctatgggccc gggggcctgc      300

acgcagccta cctgccatcc ccaccgctca gcgcctctga tgccttctca ttgctttgtg      360

ctccctgagc ctcaaggcct caagccggca gggcggggac tacgtggccc tgcagcccct      420

gtgctccgag ggtgggcctc ccatgcccca ccgtagcatc tttgcccccc c atg cac       477
                                                         Met His          
                                                         1                

tgc cca acc aca atc gca gcc tgt cct aca ata atg tgc tca acc ctg        525
Cys Pro Thr Thr Ile Ala Ala Cys Pro Thr Ile Met Cys Ser Thr Leu           
        5                   10                  15                        

gct cgc ctg gtg gcc acg cct gcc tcg ccc atc cag cag ttg gcg tgg        573
Ala Arg Leu Val Ala Thr Pro Ala Ser Pro Ile Gln Gln Leu Ala Trp           
    20                  25                  30                            

ccg gat acc act cac cct acc tgc acc ctg ggg caa cgg gcg acc cac        621
Pro Asp Thr Thr His Pro Thr Cys Thr Leu Gly Gln Arg Ala Thr His           
35                  40                  45                  50            

cat ggc ccc tgc ccc aca gct tca gtc ccg tgc tgg gcc ccc ggc ccc        669
His Gly Pro Cys Pro Thr Ala Ser Val Pro Cys Trp Ala Pro Gly Pro           
                55                  60                  65                

agg agc cct cgc ctg tgc tct acg aca tcc tgt cca gga cca tca tgg        717
Arg Ser Pro Arg Leu Cys Ser Thr Thr Ser Cys Pro Gly Pro Ser Trp           
            70                  75                  80                    

cat cca tcc agg agc gca agg aca ggg agg agc gtg agt gcc tgc tgc        765
His Pro Ser Arg Ser Ala Arg Thr Gly Arg Ser Val Ser Ala Cys Cys           
        85                  90                  95                        

gct ccc agg ccg act cac tct tcg gcg act cag gcg tct atg atg ctc        813
Ala Pro Arg Pro Thr His Ser Ser Ala Thr Gln Ala Ser Met Met Leu           
    100                 105                 110                           

cca gct cct aca gcc tgc agc agg cca gtg tgc tgt ctg agg gct tct        861
Pro Ala Pro Thr Ala Cys Ser Arg Pro Val Cys Cys Leu Arg Ala Ser           
115                 120                 125                 130           

gag gtc cta cgc tgt gct aca gct cta cag atg acc ttg tgg cca ggc        909
Glu Val Leu Arg Cys Ala Thr Ala Leu Gln Met Thr Leu Trp Pro Gly           
                135                 140                 145               

ccg gct tcg gcg gcg cct gca acc ctg tcc tgc aga cat cat tgt cct        957
Pro Ala Ser Ala Ala Pro Ala Thr Leu Ser Cys Arg His His Cys Pro           
            150                 155                 160                   

cgc ttt cca gct ccg tga gccgtgcact gcggacgtcg tcctcctccc              1005
Arg Phe Pro Ala Pro                                                       
        165                                                               

tgcaggctga tcaggtgggg aagctgaggc aggaagccct ttagtcactt gccgaaggcc     1065

acgctgttac ccatgggacc ggttttgggc ggccgaagag cactcatggg gccggattca     1125

cgccccgggc ccgttccctc ctgctctctg gtgctcctca cgccattggc cccactgcct     1185

ctcactgccc gtgagtccct gtgcccgtgt cctccttctt gaacccctca gccctcagtt     1245

aaccctcaga aagctggctc ggagaagtcc ttgtgtggta tctgggaggc agagtttgcc     1305

gtgagctgag attgtgccac tgcacgcact ccagcctggg cgacagagcg agaccccatc     1365

tcaaaaaaaa aaaaaaaggc ctcacgggac tagaagcgtc ttaccctgac ctcacacctg     1425

ctggacatca ggctggggag agaatcgggg aagagggcat tttccaacag gactggaagg     1485

ccagtcgtgg tccttggtgg tgagagctag ccaggccgcc ggccttctcc ccggaagcct     1545

gcagggtccc ctctgatccc tgcacctctg gggggtcaca ccaactgcgg gtgtttcctc     1605

accacgctgg gcgcttggtg agcacgttct gccttgagac ctggcatttc tttgataaca     1665

tttcttctcg tttcctgctc attctggaac tcctgtcagt cagatgttgg gccttttgga     1725

tagattctgt gagtccttct ttctaccttt gcttgtagat aagattttcc ttgaatccaa     1785

acacacacac tctctctgct ttttaaaaaa ttagttttgg ggctggatgt agtggcttac     1845

acctgtagtc ccaggcactt tgggaggccg aggcaggcag atcacttgag gtcaggagtt     1905

ccagaccagc ctggccaaca tggtgaaacc ccgtctctac taaaaataca aaaagtagct     1965

gaatgtggtg gtgtgcacct gtaatcccag ctactcagga ggctgaggca ggagactggc     2025

ttgaacccgg gtggcagagg ttgcagtgag ccgaaatcac accactgtac tccagcctgg     2085

tgacagagcc agactgtttt aaaataaata aaaataaaaa attggttttg g              2136


<210>  498
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  498

Met His Cys Pro Thr Thr Ile Ala Ala Cys Pro Thr Ile Met Cys Ser 
1               5                   10                  15      


Thr Leu Ala Arg Leu Val Ala Thr Pro Ala Ser Pro Ile Gln Gln Leu 
            20                  25                  30          


Ala Trp Pro Asp Thr Thr His Pro Thr Cys Thr Leu Gly Gln Arg Ala 
        35                  40                  45              


Thr His His Gly Pro Cys Pro Thr Ala Ser Val Pro Cys Trp Ala Pro 
    50                  55                  60                  


Gly Pro Arg Ser Pro Arg Leu Cys Ser Thr Thr Ser Cys Pro Gly Pro 
65                  70                  75                  80  


Ser Trp His Pro Ser Arg Ser Ala Arg Thr Gly Arg Ser Val Ser Ala 
                85                  90                  95      


Cys Cys Ala Pro Arg Pro Thr His Ser Ser Ala Thr Gln Ala Ser Met 
            100                 105                 110         


Met Leu Pro Ala Pro Thr Ala Cys Ser Arg Pro Val Cys Cys Leu Arg 
        115                 120                 125             


Ala Ser Glu Val Leu Arg Cys Ala Thr Ala Leu Gln Met Thr Leu Trp 
    130                 135                 140                 


Pro Gly Pro Ala Ser Ala Ala Pro Ala Thr Leu Ser Cys Arg His His 
145                 150                 155                 160 


Cys Pro Arg Phe Pro Ala Pro 
                165         


<210>  499
<211>  6640
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (265)..(3063)

<400>  499
gagcgggccg acggccattt tgtgaagcgg cgaaggaggt ggtggctgcg ttgggctccg       60

ggaagccgtt cgggctgggg ctgtcggccg cggggcggag gcactcgcgc ggggggtaat      120

tcggggtctg ggttctggtg ccgcgcagct ttccccgtct aaaagttggt tttaattggt      180

tgcccacagg attgacttgg cctctacttc ttgttaagga aattcatctc ttgttttatc      240

aggtgtgtgt ggtttcagcg cagc atg gct gtg gtc atc cgt ttg caa ggt         291
                           Met Ala Val Val Ile Arg Leu Gln Gly            
                           1               5                              

ctc cca att gtg gcg ggg acc atg gac att cgc cac ttc ttc tct gga        339
Leu Pro Ile Val Ala Gly Thr Met Asp Ile Arg His Phe Phe Ser Gly           
10                  15                  20                  25            

ttg acc att cct gat ggg ggc gtg cat att gta ggg ggt gaa ctg ggt        387
Leu Thr Ile Pro Asp Gly Gly Val His Ile Val Gly Gly Glu Leu Gly           
                30                  35                  40                

gag gct ttc atc gtt ttt gcc act gat gaa gat gca agg ctt ggt atg        435
Glu Ala Phe Ile Val Phe Ala Thr Asp Glu Asp Ala Arg Leu Gly Met           
            45                  50                  55                    

atg cgc aca ggt ggt aca att aaa ggg tca aaa gta aca cta ttg ttg        483
Met Arg Thr Gly Gly Thr Ile Lys Gly Ser Lys Val Thr Leu Leu Leu           
        60                  65                  70                        

agt agt aag acg gaa atg cag aat atg att gaa ctg agt cgt agg cgt        531
Ser Ser Lys Thr Glu Met Gln Asn Met Ile Glu Leu Ser Arg Arg Arg           
    75                  80                  85                            

ttt gaa act gcc aac tta gat ata cca cca gca aat gcc agt aga tca        579
Phe Glu Thr Ala Asn Leu Asp Ile Pro Pro Ala Asn Ala Ser Arg Ser           
90                  95                  100                 105           

gga cca cca cct agc tca gga atg agt agc agg gta aac ttg ccc aca        627
Gly Pro Pro Pro Ser Ser Gly Met Ser Ser Arg Val Asn Leu Pro Thr           
                110                 115                 120               

aca gta tcc aac ttt aat aat cca tca ccc agt gta gtt act gcc acc        675
Thr Val Ser Asn Phe Asn Asn Pro Ser Pro Ser Val Val Thr Ala Thr           
            125                 130                 135                   

act tct gtt cat gaa agc aac aaa aac ata cag aca ttt tcc aca gcc        723
Thr Ser Val His Glu Ser Asn Lys Asn Ile Gln Thr Phe Ser Thr Ala           
        140                 145                 150                       

agc gta gga aca gct cct cca aat atg ggg gct tcc ttt ggg agc cca        771
Ser Val Gly Thr Ala Pro Pro Asn Met Gly Ala Ser Phe Gly Ser Pro           
    155                 160                 165                           

acg ttt agc tca act gtt cca agc aca gcc tct cca atg aac aca gtc        819
Thr Phe Ser Ser Thr Val Pro Ser Thr Ala Ser Pro Met Asn Thr Val           
170                 175                 180                 185           

ccg ccg cca cca att cct cca att cca gcg atg cca tct ctg cca cca        867
Pro Pro Pro Pro Ile Pro Pro Ile Pro Ala Met Pro Ser Leu Pro Pro           
                190                 195                 200               

atg cca tcc att ccc cca att cca gtt cct cct cca gta cct aca ttg        915
Met Pro Ser Ile Pro Pro Ile Pro Val Pro Pro Pro Val Pro Thr Leu           
            205                 210                 215                   

cct cct gtg cct cct gtg ccc ccg att ccc cca gtt cct tct gtg cca        963
Pro Pro Val Pro Pro Val Pro Pro Ile Pro Pro Val Pro Ser Val Pro           
        220                 225                 230                       

ccc atg acc cca ctg cca ccc atg tcg ggc atg ccg ccc ttg aat ccg       1011
Pro Met Thr Pro Leu Pro Pro Met Ser Gly Met Pro Pro Leu Asn Pro           
    235                 240                 245                           

cca cct gtg gca cct cta cct gct gga atg aat ggc tct gga gca cct       1059
Pro Pro Val Ala Pro Leu Pro Ala Gly Met Asn Gly Ser Gly Ala Pro           
250                 255                 260                 265           

atg aat ttg aac aat aat ctg aat cct atg ttt ctt ggt ccg ttg aat       1107
Met Asn Leu Asn Asn Asn Leu Asn Pro Met Phe Leu Gly Pro Leu Asn           
                270                 275                 280               

cct gtt aac cct atc cag atg aac tct cag agc agt gtg aag cca ctc       1155
Pro Val Asn Pro Ile Gln Met Asn Ser Gln Ser Ser Val Lys Pro Leu           
            285                 290                 295                   

ccc atc aac cct gat gat ctg tat gtc agt gtg cat gga atg ccc ttt       1203
Pro Ile Asn Pro Asp Asp Leu Tyr Val Ser Val His Gly Met Pro Phe           
        300                 305                 310                       

tct gca atg gaa aat gat gtc aga gat ttt ttt cat ggg ctc cgt gtt       1251
Ser Ala Met Glu Asn Asp Val Arg Asp Phe Phe His Gly Leu Arg Val           
    315                 320                 325                           

gat gca gtg cat ttg ttg aaa gat cat gta ggt cga aat aat ggg aat       1299
Asp Ala Val His Leu Leu Lys Asp His Val Gly Arg Asn Asn Gly Asn           
330                 335                 340                 345           

gga ttg gtt aag ttt ctc tcc cct caa gat aca ttt gaa gct ttg aaa       1347
Gly Leu Val Lys Phe Leu Ser Pro Gln Asp Thr Phe Glu Ala Leu Lys           
                350                 355                 360               

cga aac aga atg ctg atg att caa cgc tat gtg gaa gtt agc cct gcc       1395
Arg Asn Arg Met Leu Met Ile Gln Arg Tyr Val Glu Val Ser Pro Ala           
            365                 370                 375                   

aca gaa aga cag tgg gta gct gct gga ggc cat atc act ttt aag caa       1443
Thr Glu Arg Gln Trp Val Ala Ala Gly Gly His Ile Thr Phe Lys Gln           
        380                 385                 390                       

aat atg gga cct tct gga caa act cat ccc cct cct cag aca ctt ccc       1491
Asn Met Gly Pro Ser Gly Gln Thr His Pro Pro Pro Gln Thr Leu Pro           
    395                 400                 405                           

agg tca aaa tcg ccc agt ggg cag aaa aga tca agg tca aga tca cca       1539
Arg Ser Lys Ser Pro Ser Gly Gln Lys Arg Ser Arg Ser Arg Ser Pro           
410                 415                 420                 425           

cat gag gct ggt ttt tgt gtt tac ttg aaa ggg cta cca ttt gaa gca       1587
His Glu Ala Gly Phe Cys Val Tyr Leu Lys Gly Leu Pro Phe Glu Ala           
                430                 435                 440               

gaa aac aaa cat gtc att gat ttt ttt aaa aag ctg gat att gtg gaa       1635
Glu Asn Lys His Val Ile Asp Phe Phe Lys Lys Leu Asp Ile Val Glu           
            445                 450                 455                   

gat agt att tat ata gct tat gga ccc aat ggg aaa gca act ggc gaa       1683
Asp Ser Ile Tyr Ile Ala Tyr Gly Pro Asn Gly Lys Ala Thr Gly Glu           
        460                 465                 470                       

ggc ttt gta gag ttc aga aat gag gct gac tat aag gct gct ctg tgt       1731
Gly Phe Val Glu Phe Arg Asn Glu Ala Asp Tyr Lys Ala Ala Leu Cys           
    475                 480                 485                           

cgt cat aaa cag tac atg ggc aat cgc ttt att caa gtt cat cca att       1779
Arg His Lys Gln Tyr Met Gly Asn Arg Phe Ile Gln Val His Pro Ile           
490                 495                 500                 505           

act aag aaa ggt atg cta gaa aag ata gat atg att cga aaa aga ctg       1827
Thr Lys Lys Gly Met Leu Glu Lys Ile Asp Met Ile Arg Lys Arg Leu           
                510                 515                 520               

cag aac ttc agc tat gac cag agg gaa atg ata cta aat cca gag ggg       1875
Gln Asn Phe Ser Tyr Asp Gln Arg Glu Met Ile Leu Asn Pro Glu Gly           
            525                 530                 535                   

gat gtc aac tct gcc aaa gtc tgt gcc cac ata aca aat att cca ttc       1923
Asp Val Asn Ser Ala Lys Val Cys Ala His Ile Thr Asn Ile Pro Phe           
        540                 545                 550                       

agc att aca aag atg gat gtt ctt cag ttc cta gaa gga atc cca gtg       1971
Ser Ile Thr Lys Met Asp Val Leu Gln Phe Leu Glu Gly Ile Pro Val           
    555                 560                 565                           

gat gaa aat gct gta cat gtt ctt gtt gat aac aat ggg caa ggt cta       2019
Asp Glu Asn Ala Val His Val Leu Val Asp Asn Asn Gly Gln Gly Leu           
570                 575                 580                 585           

gga cag gca ttg gtt cag ttt aaa aat gaa gat gat gca cgt aag tct       2067
Gly Gln Ala Leu Val Gln Phe Lys Asn Glu Asp Asp Ala Arg Lys Ser           
                590                 595                 600               

gaa cgc tta cac cgt aaa aaa ctt aat ggg aga gaa gct ttt gtt cat       2115
Glu Arg Leu His Arg Lys Lys Leu Asn Gly Arg Glu Ala Phe Val His           
            605                 610                 615                   

gta gtt acc cta gaa gat atg aga gag att gag aaa aat ccc cct gcc       2163
Val Val Thr Leu Glu Asp Met Arg Glu Ile Glu Lys Asn Pro Pro Ala           
        620                 625                 630                       

caa gga aaa aag gga tta aag atg cct gtg cca ggt aat cct gca gtt       2211
Gln Gly Lys Lys Gly Leu Lys Met Pro Val Pro Gly Asn Pro Ala Val           
    635                 640                 645                           

cca gga atg ccc aat gcg gga ctg ccc ggt gtg gga ctg ccc agt gca       2259
Pro Gly Met Pro Asn Ala Gly Leu Pro Gly Val Gly Leu Pro Ser Ala           
650                 655                 660                 665           

gga ctt ccc ggt gca ggc ctg ccc agc aca gga ctg cct ggt tca gca       2307
Gly Leu Pro Gly Ala Gly Leu Pro Ser Thr Gly Leu Pro Gly Ser Ala           
                670                 675                 680               

ata acc agt gca gga ctg cct ggt gcg gga atg ccc agt gca gga ata       2355
Ile Thr Ser Ala Gly Leu Pro Gly Ala Gly Met Pro Ser Ala Gly Ile           
            685                 690                 695                   

cct agt gca gga ggt gaa gag cat gcc ttc ctg act gta gga tca aag       2403
Pro Ser Ala Gly Gly Glu Glu His Ala Phe Leu Thr Val Gly Ser Lys           
        700                 705                 710                       

gaa gcc aat aat ggg cct cca ttt aac ttt cct ggt aat ttt ggt gga       2451
Glu Ala Asn Asn Gly Pro Pro Phe Asn Phe Pro Gly Asn Phe Gly Gly           
    715                 720                 725                           

tca aat gcc ttt ggg cca cca atc cct cct cca gga tta gga ggc ggg       2499
Ser Asn Ala Phe Gly Pro Pro Ile Pro Pro Pro Gly Leu Gly Gly Gly           
730                 735                 740                 745           

gcc ttt ggt gat gct agg cct ggt atg cct tca gtt gga aac agt ggt       2547
Ala Phe Gly Asp Ala Arg Pro Gly Met Pro Ser Val Gly Asn Ser Gly           
                750                 755                 760               

ttg cct ggt cta gga ctg gat gtt ccg ggt ttt gga ggt gga cca aac       2595
Leu Pro Gly Leu Gly Leu Asp Val Pro Gly Phe Gly Gly Gly Pro Asn           
            765                 770                 775                   

aat tta agt ggg cca tcg gga ttt gga ggg ggc cct cag aat ttt gga       2643
Asn Leu Ser Gly Pro Ser Gly Phe Gly Gly Gly Pro Gln Asn Phe Gly           
        780                 785                 790                       

aat ggc cct ggt agc tta ggc ggt ccc ccg ggg ttt gga agt ggc cct       2691
Asn Gly Pro Gly Ser Leu Gly Gly Pro Pro Gly Phe Gly Ser Gly Pro           
    795                 800                 805                           

cct ggt ctt gga agt gcc cct ggg cat ttg ggt ggg cca cca gct ttt       2739
Pro Gly Leu Gly Ser Ala Pro Gly His Leu Gly Gly Pro Pro Ala Phe           
810                 815                 820                 825           

ggg cct ggc ccc ggc ccc ggc ccc ggc cct ggc cca atc cat att ggt       2787
Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Ile His Ile Gly           
                830                 835                 840               

ggt ccc cct ggc ttt gca tct agt tct gga aaa cca gga ccg aca gta       2835
Gly Pro Pro Gly Phe Ala Ser Ser Ser Gly Lys Pro Gly Pro Thr Val           
            845                 850                 855                   

att aaa gtg caa aac atg ccc ttt act gtg tct att gat gag att tta       2883
Ile Lys Val Gln Asn Met Pro Phe Thr Val Ser Ile Asp Glu Ile Leu           
        860                 865                 870                       

gat ttc ttt tat ggc tat caa gta atc cca ggc tca gtg tgt tta aaa       2931
Asp Phe Phe Tyr Gly Tyr Gln Val Ile Pro Gly Ser Val Cys Leu Lys           
    875                 880                 885                           

tac aat gaa aaa ggt atg ccc aca ggt gaa gcc atg gtg gcc ttt gag       2979
Tyr Asn Glu Lys Gly Met Pro Thr Gly Glu Ala Met Val Ala Phe Glu           
890                 895                 900                 905           

tct cgg gat gaa gcc aca gct gct gtc att gac tta aat gac agg cct       3027
Ser Arg Asp Glu Ala Thr Ala Ala Val Ile Asp Leu Asn Asp Arg Pro           
                910                 915                 920               

ata ggt tca aga aaa gta aaa ctt gta tta ggg tag ccattcacat            3073
Ile Gly Ser Arg Lys Val Lys Leu Val Leu Gly                               
            925                 930                                       

cattttttat agggtagatc ttcatattgc tgtgattaat gcatccagat tgttttccta     3133

gtatttccag gttagaacct gtggattgtt tcaattgcat atagcttggt ttccataaca     3193

tagagcattg gttgactgtt tacagaagac tcactcacca ggataaacat tgctgtatgt     3253

tacagtaaag ctatctggag agaacacata aatgattttg gcataccatt agagaaacca     3313

tttgtaaaac tcaaatgacc acataaagct tatcaaggag tctagattgg ttttgtttta     3373

taccatatgg gatgaagaaa atagaaatgt cagtagaact cattgagggt gctcttgcca     3433

gctgctgaaa atagaagttg gctactctca gaatttggtt taaagctgga cagatttgct     3493

ttgttatagg gtaaagcttt gtctaaagtc ctcattttct tttaaaattg aataaaattt     3553

ctgtatacag attcattgta tgtaccttta ttgcttctta agggtccttg ctgtatagac     3613

agtcctgctt cagaagttgc tgctttgttt gtctaattga ctcatttgta aatgagcaga     3673

actgttttgt tggttttttt ccctaaatat aaaagtccac acttcgtttg tgctataacc     3733

tcaaactttg atttctaatg tcacacttaa aactgtgtgg aataagactt ttgccataaa     3793

aataaactat ggagtccttt atctaccaga gcctttttgg tttgaccgcc acgatttagg     3853

ttagtcagtt taaaaattgt tcatgttgtt tggatggtat cgaaaaccag aaaccacttt     3913

taataatgtg tttaagatac ttgatttgaa gtccttttca tatggactaa ttgtagtatc     3973

aatttcctcc tgtcccgatt atgtgaaatt ttggccttta aacaaagagg ggcccattca     4033

taagaaagtg ttatatctag gtttttaaaa ctgaagttga aattatcttt gttagcagta     4093

gtagtataga ataaaagatc cgtatgctgg ttcgtagatt gatacgtgtt agtcctgtta     4153

tttggaggct ttttggcata gttgttcgat caggagcctg tttactaaaa gtcttcatac     4213

agagtacaag tgcagccgcc agaggagaaa attgagattc ttgacccttt catactcttt     4273

tctttggtat tcaggacact aaggcaggag gaccacatga gttctggttg gtaagtgtcc     4333

ttgtcatgaa aacacttgcc ttacaaggct ctaattatga tttccctagt cagtgctctg     4393

aagatgtgtc acattatatt ataaacaata cggaagggga gataggtgag atgatatgaa     4453

aaacaaattt tctcactgtc ataaaaggct ctaattatgg ttactttcct tgtgatgaaa     4513

aacttggcct tacagggctc tagttatggt tactttccct agtcaatgct ctgaaaatgt     4573

gtcacattat aaacaataca gaaggagaga tagatgagag atcatgaaaa ccaaatttta     4633

tcttttacat ggcccctttg tcttcgtttg aaacatcccc aacatttcct acaaatcagc     4693

gtagttacaa aggggtcagt cttttaaaat aagtatttcc tattaaacta tatatatata     4753

cagtgccttt ttggtgttgt gagtcagtgg aacactgaaa tacagcggtt gtgtaattta     4813

agagtggcaa cagtttcatt tgataagatt tgaaaaggct ttttatcact acaatcttag     4873

aggattgaca gtacaggatt tttgtttaag agaaggattg tttagactca agaggtgact     4933

atgttgtggg tcttttgata attcatgaat acagatttgc tttgaccgat cactagatac     4993

tgcctcctca atttcaaaag caatataacg tttgtatatg ctgtttaatt taagttaatg     5053

ttaagtaatc atttctcatt ccaaagacaa tgcaaaaaac ttcagcactg cttgagagtt     5113

gtatttcagc cacagatatt ttctccattg gaaagctatt ttcattttag aaaaatgggt     5173

tgtttgaaga tgaaagtctt ttatcttttt tcacaattta ttttggttat atgttcgtac     5233

attcttatta aatatttcat acactttatt gcaactactt tgttatttct acatcttaga     5293

taaatgctga aaaggaaaac gatttcattg ttcatctaat taaataaatt aaaagagcgg     5353

tttgtgtaga aattggagag aactatgttt tatatgaatc acaacagtgc tcgttgtgga     5413

ctgtaattaa atgctttgcc ctctggaact tgatttttgt gtatctgaga tttattaaca     5473

gtgctaactg ctaaggatac tgtttatctt gttctgggca ttggagtttc agtttttaaa     5533

aaattcttga aaatgtattc tgtgaaacta ctcatacctc tcttcctgcg aattttctcc     5593

taagaactag gtttggggta gaaatgaatt gacattattt tctcatttgc tttgtatggt     5653

atgaaggatt tgtaaagctt tgctcaaagt tgtgtgcatt tgtaaacact atcatgatat     5713

tttcaatttt atgtgtaaat tttattgtct gtttttggtg actctgacat taatggaaga     5773

gaatattttc cattagattt aatttttttt cctctccctt ctgatttttt ttttattggt     5833

gttcattttt cttttgattt aaaggattag agaaatctac aaatgtatgt cataaataag     5893

caaatttgta aacttttctg aactttagtg aaacatttag ttcacaagca taatttggag     5953

gtgtgttctg tgtttacaca gtagtttgga tgtacaatta ttattagtgg ctttttaaaa     6013

aatgaaacag tgttaagtga aatgtagttc ctagctttgt actccaagtt gtcaaagcat     6073

caacaatgaa aattcgatta ggaaacttta tttaaaattt caggtagtaa tattcagtgt     6133

agttaaggcc agtcttaacc cactggatga aaatctagga ctgtatggaa gtaagcaaac     6193

attacatttt taggtggaaa tagtcagcct tgcataaaaa caaggatgcg tgaaagcctt     6253

aaattccagc tcccttttac tggagtctgt ggttgtgtac aggtatgggc caagtgtaaa     6313

atctcatcaa ttttaagaac actcgggaaa tgagtaaaga aaatgtaaaa ttgctgctag     6373

tcaaatcttt tggaaagaat ttctggaagt ggtcacttta aaaattattt tccacccttg     6433

caaaattgcc acatttaaat tgttttactg gcagttctat agtagtccag actttagaaa     6493

ccaaacacaa caaaatggct tgttgccaat atggccacaa cattgccagc aaatactgcc     6553

ttggcatcac tcagcagagg tttttgttta taaagatgaa gtcttgaata ctgttcaata     6613

aacttgtcaa aaaataaaaa aaaaaaa                                         6640


<210>  500
<211>  932
<212>  PRT
<213>  Homo sapiens

<400>  500

Met Ala Val Val Ile Arg Leu Gln Gly Leu Pro Ile Val Ala Gly Thr 
1               5                   10                  15      


Met Asp Ile Arg His Phe Phe Ser Gly Leu Thr Ile Pro Asp Gly Gly 
            20                  25                  30          


Val His Ile Val Gly Gly Glu Leu Gly Glu Ala Phe Ile Val Phe Ala 
        35                  40                  45              


Thr Asp Glu Asp Ala Arg Leu Gly Met Met Arg Thr Gly Gly Thr Ile 
    50                  55                  60                  


Lys Gly Ser Lys Val Thr Leu Leu Leu Ser Ser Lys Thr Glu Met Gln 
65                  70                  75                  80  


Asn Met Ile Glu Leu Ser Arg Arg Arg Phe Glu Thr Ala Asn Leu Asp 
                85                  90                  95      


Ile Pro Pro Ala Asn Ala Ser Arg Ser Gly Pro Pro Pro Ser Ser Gly 
            100                 105                 110         


Met Ser Ser Arg Val Asn Leu Pro Thr Thr Val Ser Asn Phe Asn Asn 
        115                 120                 125             


Pro Ser Pro Ser Val Val Thr Ala Thr Thr Ser Val His Glu Ser Asn 
    130                 135                 140                 


Lys Asn Ile Gln Thr Phe Ser Thr Ala Ser Val Gly Thr Ala Pro Pro 
145                 150                 155                 160 


Asn Met Gly Ala Ser Phe Gly Ser Pro Thr Phe Ser Ser Thr Val Pro 
                165                 170                 175     


Ser Thr Ala Ser Pro Met Asn Thr Val Pro Pro Pro Pro Ile Pro Pro 
            180                 185                 190         


Ile Pro Ala Met Pro Ser Leu Pro Pro Met Pro Ser Ile Pro Pro Ile 
        195                 200                 205             


Pro Val Pro Pro Pro Val Pro Thr Leu Pro Pro Val Pro Pro Val Pro 
    210                 215                 220                 


Pro Ile Pro Pro Val Pro Ser Val Pro Pro Met Thr Pro Leu Pro Pro 
225                 230                 235                 240 


Met Ser Gly Met Pro Pro Leu Asn Pro Pro Pro Val Ala Pro Leu Pro 
                245                 250                 255     


Ala Gly Met Asn Gly Ser Gly Ala Pro Met Asn Leu Asn Asn Asn Leu 
            260                 265                 270         


Asn Pro Met Phe Leu Gly Pro Leu Asn Pro Val Asn Pro Ile Gln Met 
        275                 280                 285             


Asn Ser Gln Ser Ser Val Lys Pro Leu Pro Ile Asn Pro Asp Asp Leu 
    290                 295                 300                 


Tyr Val Ser Val His Gly Met Pro Phe Ser Ala Met Glu Asn Asp Val 
305                 310                 315                 320 


Arg Asp Phe Phe His Gly Leu Arg Val Asp Ala Val His Leu Leu Lys 
                325                 330                 335     


Asp His Val Gly Arg Asn Asn Gly Asn Gly Leu Val Lys Phe Leu Ser 
            340                 345                 350         


Pro Gln Asp Thr Phe Glu Ala Leu Lys Arg Asn Arg Met Leu Met Ile 
        355                 360                 365             


Gln Arg Tyr Val Glu Val Ser Pro Ala Thr Glu Arg Gln Trp Val Ala 
    370                 375                 380                 


Ala Gly Gly His Ile Thr Phe Lys Gln Asn Met Gly Pro Ser Gly Gln 
385                 390                 395                 400 


Thr His Pro Pro Pro Gln Thr Leu Pro Arg Ser Lys Ser Pro Ser Gly 
                405                 410                 415     


Gln Lys Arg Ser Arg Ser Arg Ser Pro His Glu Ala Gly Phe Cys Val 
            420                 425                 430         


Tyr Leu Lys Gly Leu Pro Phe Glu Ala Glu Asn Lys His Val Ile Asp 
        435                 440                 445             


Phe Phe Lys Lys Leu Asp Ile Val Glu Asp Ser Ile Tyr Ile Ala Tyr 
    450                 455                 460                 


Gly Pro Asn Gly Lys Ala Thr Gly Glu Gly Phe Val Glu Phe Arg Asn 
465                 470                 475                 480 


Glu Ala Asp Tyr Lys Ala Ala Leu Cys Arg His Lys Gln Tyr Met Gly 
                485                 490                 495     


Asn Arg Phe Ile Gln Val His Pro Ile Thr Lys Lys Gly Met Leu Glu 
            500                 505                 510         


Lys Ile Asp Met Ile Arg Lys Arg Leu Gln Asn Phe Ser Tyr Asp Gln 
        515                 520                 525             


Arg Glu Met Ile Leu Asn Pro Glu Gly Asp Val Asn Ser Ala Lys Val 
    530                 535                 540                 


Cys Ala His Ile Thr Asn Ile Pro Phe Ser Ile Thr Lys Met Asp Val 
545                 550                 555                 560 


Leu Gln Phe Leu Glu Gly Ile Pro Val Asp Glu Asn Ala Val His Val 
                565                 570                 575     


Leu Val Asp Asn Asn Gly Gln Gly Leu Gly Gln Ala Leu Val Gln Phe 
            580                 585                 590         


Lys Asn Glu Asp Asp Ala Arg Lys Ser Glu Arg Leu His Arg Lys Lys 
        595                 600                 605             


Leu Asn Gly Arg Glu Ala Phe Val His Val Val Thr Leu Glu Asp Met 
    610                 615                 620                 


Arg Glu Ile Glu Lys Asn Pro Pro Ala Gln Gly Lys Lys Gly Leu Lys 
625                 630                 635                 640 


Met Pro Val Pro Gly Asn Pro Ala Val Pro Gly Met Pro Asn Ala Gly 
                645                 650                 655     


Leu Pro Gly Val Gly Leu Pro Ser Ala Gly Leu Pro Gly Ala Gly Leu 
            660                 665                 670         


Pro Ser Thr Gly Leu Pro Gly Ser Ala Ile Thr Ser Ala Gly Leu Pro 
        675                 680                 685             


Gly Ala Gly Met Pro Ser Ala Gly Ile Pro Ser Ala Gly Gly Glu Glu 
    690                 695                 700                 


His Ala Phe Leu Thr Val Gly Ser Lys Glu Ala Asn Asn Gly Pro Pro 
705                 710                 715                 720 


Phe Asn Phe Pro Gly Asn Phe Gly Gly Ser Asn Ala Phe Gly Pro Pro 
                725                 730                 735     


Ile Pro Pro Pro Gly Leu Gly Gly Gly Ala Phe Gly Asp Ala Arg Pro 
            740                 745                 750         


Gly Met Pro Ser Val Gly Asn Ser Gly Leu Pro Gly Leu Gly Leu Asp 
        755                 760                 765             


Val Pro Gly Phe Gly Gly Gly Pro Asn Asn Leu Ser Gly Pro Ser Gly 
    770                 775                 780                 


Phe Gly Gly Gly Pro Gln Asn Phe Gly Asn Gly Pro Gly Ser Leu Gly 
785                 790                 795                 800 


Gly Pro Pro Gly Phe Gly Ser Gly Pro Pro Gly Leu Gly Ser Ala Pro 
                805                 810                 815     


Gly His Leu Gly Gly Pro Pro Ala Phe Gly Pro Gly Pro Gly Pro Gly 
            820                 825                 830         


Pro Gly Pro Gly Pro Ile His Ile Gly Gly Pro Pro Gly Phe Ala Ser 
        835                 840                 845             


Ser Ser Gly Lys Pro Gly Pro Thr Val Ile Lys Val Gln Asn Met Pro 
    850                 855                 860                 


Phe Thr Val Ser Ile Asp Glu Ile Leu Asp Phe Phe Tyr Gly Tyr Gln 
865                 870                 875                 880 


Val Ile Pro Gly Ser Val Cys Leu Lys Tyr Asn Glu Lys Gly Met Pro 
                885                 890                 895     


Thr Gly Glu Ala Met Val Ala Phe Glu Ser Arg Asp Glu Ala Thr Ala 
            900                 905                 910         


Ala Val Ile Asp Leu Asn Asp Arg Pro Ile Gly Ser Arg Lys Val Lys 
        915                 920                 925             


Leu Val Leu Gly 
    930         


<210>  501
<211>  2816
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (449)..(1918)

<400>  501
tgcgcagcaa tgccatcggt taaagcgcat gcgcaagatg agctattgcg gaagtgaggg       60

gagggagagg ccgagagaaa tttcggtact gcgcatgaac cgagcgtgac gttgaggttt      120

gaaataaccg gcaaagagta aaggctgaaa ctagcttcct gaaagcttcg tagggcccga      180

gccctgtgag cccaggttct gcgcccacta ggaggtgtca tgctgactgc tttttttaaa      240

gccctagaat cttggcttcg gcgtttgggg taagctccgt tctcgttctc aagcgcgttt      300

ccgcgaactc tcgcgggatt gacgggccgt ctcgagagcc ggcatctcct aggagctagt      360

cctggtcctc ggctaggcgg cttggggtcg cggcgtaact ggggagccag cctgacgccg      420

gcggaccccg cctgtgatcc tggcaacg atg gat gat gac ttg atg ttg gca         472
                               Met Asp Asp Asp Leu Met Leu Ala            
                               1               5                          

ctg cgg ctt cag gag gag tgg aac ttg cag gag gcg gag cgc gat cat        520
Leu Arg Leu Gln Glu Glu Trp Asn Leu Gln Glu Ala Glu Arg Asp His           
    10                  15                  20                            

gcc cag gag tcc ctg tcg cta gtg gac gcg tcg tgg gag ttg gtg gac        568
Ala Gln Glu Ser Leu Ser Leu Val Asp Ala Ser Trp Glu Leu Val Asp           
25                  30                  35                  40            

ccc aca ccg gac ttg cag gca ctg ttt gtt cag ttt aac gac caa ttc        616
Pro Thr Pro Asp Leu Gln Ala Leu Phe Val Gln Phe Asn Asp Gln Phe           
                45                  50                  55                

ttc tgg ggc cag ctg gag gcc gtc gag gtg aag tgg agc gtg cga atg        664
Phe Trp Gly Gln Leu Glu Ala Val Glu Val Lys Trp Ser Val Arg Met           
            60                  65                  70                    

acc ctg tgt gct ggg ata tgc agc tat gaa ggg aag ggt gga atg tgt        712
Thr Leu Cys Ala Gly Ile Cys Ser Tyr Glu Gly Lys Gly Gly Met Cys           
        75                  80                  85                        

tcc atc cgt ctc agc gaa ccc ctt ttg aag ttg agg cca aga aag gat        760
Ser Ile Arg Leu Ser Glu Pro Leu Leu Lys Leu Arg Pro Arg Lys Asp           
    90                  95                  100                           

ctt gta gag acc ctc ctg cat gaa atg ata cat gcc tat tta ttt gtc        808
Leu Val Glu Thr Leu Leu His Glu Met Ile His Ala Tyr Leu Phe Val           
105                 110                 115                 120           

act aat aac gac aaa gac cga gaa ggg cat ggt cca gaa ttt tgt aaa        856
Thr Asn Asn Asp Lys Asp Arg Glu Gly His Gly Pro Glu Phe Cys Lys           
                125                 130                 135               

cat atg cat cgc atc aac agc ctg act gga gcc aat ata acg gta tac        904
His Met His Arg Ile Asn Ser Leu Thr Gly Ala Asn Ile Thr Val Tyr           
            140                 145                 150                   

cat act ttt cac gat gag gtg gat gag tat cgg cga cac tgg tgg cgc        952
His Thr Phe His Asp Glu Val Asp Glu Tyr Arg Arg His Trp Trp Arg           
        155                 160                 165                       

tgc aat ggg ccg tgc cag cac agg cca ccg tat tac ggc tat gtc aaa       1000
Cys Asn Gly Pro Cys Gln His Arg Pro Pro Tyr Tyr Gly Tyr Val Lys           
    170                 175                 180                           

cga gct act aac agg gaa ccc tct gct cat gac tat tgg tgg gct gag       1048
Arg Ala Thr Asn Arg Glu Pro Ser Ala His Asp Tyr Trp Trp Ala Glu           
185                 190                 195                 200           

cac cag aaa acc tgt gga ggc act tac ata aaa atc aag gaa cca gag       1096
His Gln Lys Thr Cys Gly Gly Thr Tyr Ile Lys Ile Lys Glu Pro Glu           
                205                 210                 215               

aat tac tca aaa aaa ggc aaa gga aag gca aaa cta gga aag gaa cca       1144
Asn Tyr Ser Lys Lys Gly Lys Gly Lys Ala Lys Leu Gly Lys Glu Pro           
            220                 225                 230                   

gta ttg gcc gca gag aat aaa gat aaa ccc aac aga ggt gag gcc cag       1192
Val Leu Ala Ala Glu Asn Lys Asp Lys Pro Asn Arg Gly Glu Ala Gln           
        235                 240                 245                       

cta gta atc cct ttt agt ggg aaa gga tat gtt cta gga gaa aca agc       1240
Leu Val Ile Pro Phe Ser Gly Lys Gly Tyr Val Leu Gly Glu Thr Ser           
    250                 255                 260                           

aat tta cct tca cct ggg aaa ctg atc act tca cat gcc att aat aaa       1288
Asn Leu Pro Ser Pro Gly Lys Leu Ile Thr Ser His Ala Ile Asn Lys           
265                 270                 275                 280           

acc caa gat ctt tta aat caa aac cat tca gca aat gct gta aga cct       1336
Thr Gln Asp Leu Leu Asn Gln Asn His Ser Ala Asn Ala Val Arg Pro           
                285                 290                 295               

aat tct aaa atc aag gtg aaa ttt gaa cag aat ggt tca agt aaa aat       1384
Asn Ser Lys Ile Lys Val Lys Phe Glu Gln Asn Gly Ser Ser Lys Asn           
            300                 305                 310                   

tct cat ctg gtc tcc cct gct gtt agt aac agt cac caa aat gtt cta       1432
Ser His Leu Val Ser Pro Ala Val Ser Asn Ser His Gln Asn Val Leu           
        315                 320                 325                       

agc aac tac ttt cct aga gta tca ttt gcc aac caa aag gct ttc aga       1480
Ser Asn Tyr Phe Pro Arg Val Ser Phe Ala Asn Gln Lys Ala Phe Arg           
    330                 335                 340                           

ggt gtg aat gga tct cca agg ata agt gta aca gtt ggc aac atc cct       1528
Gly Val Asn Gly Ser Pro Arg Ile Ser Val Thr Val Gly Asn Ile Pro           
345                 350                 355                 360           

aaa aac tca gtc tct tct agt tct cag aga agg gtt tca tct tct aag       1576
Lys Asn Ser Val Ser Ser Ser Ser Gln Arg Arg Val Ser Ser Ser Lys           
                365                 370                 375               

ata tcc cta aga aat tct tca aaa gta acg gaa tca gca tct gtg atg       1624
Ile Ser Leu Arg Asn Ser Ser Lys Val Thr Glu Ser Ala Ser Val Met           
            380                 385                 390                   

cca tcc cag gat gtg agt ggg tct gaa gat aca ttc cca aat aaa cga       1672
Pro Ser Gln Asp Val Ser Gly Ser Glu Asp Thr Phe Pro Asn Lys Arg           
        395                 400                 405                       

cct agg cta gaa gat aag act gtt ttt gac aat ttt ttt atc aag aaa       1720
Pro Arg Leu Glu Asp Lys Thr Val Phe Asp Asn Phe Phe Ile Lys Lys           
    410                 415                 420                           

gag caa ata aaa agc agt ggt aat gat cca aag tat agt aca acc aca       1768
Glu Gln Ile Lys Ser Ser Gly Asn Asp Pro Lys Tyr Ser Thr Thr Thr           
425                 430                 435                 440           

gct cag aat tcc agc agt tca tcc agt cag agc aaa atg gtt aat tgc       1816
Ala Gln Asn Ser Ser Ser Ser Ser Ser Gln Ser Lys Met Val Asn Cys           
                445                 450                 455               

cca gtt tgt cag aat gaa gtt ctg gag tct cag att aat gag cac ttg       1864
Pro Val Cys Gln Asn Glu Val Leu Glu Ser Gln Ile Asn Glu His Leu           
            460                 465                 470                   

gac tgg tgc ctt gaa ggt gac agc atc aaa gtc aaa agc gaa gaa agt       1912
Asp Trp Cys Leu Glu Gly Asp Ser Ile Lys Val Lys Ser Glu Glu Ser           
        475                 480                 485                       

ctt tga aaaaggtttc aaagtctcaa gtaccacctg tattatctca ctaatgtgct        1968
Leu                                                                       
                                                                          

atgtcagcca gtcaggaagt tctggttaat actaagattt gtaggttata atctagttca     2028

cataaccaat agaaagtgtc ctattttata tatacgcata taagattgta attttaagat     2088

gttttgtgtc tcagggtgct acattcactc ttgccttagg tatactgtaa cccaggttct     2148

gcctgtcgtg tataagtttt agatactttt gttctttctt gctcttaagg attttaaaaa     2208

cctgttaatc tttttatttg tatactttcc taaaaatatt catatgggga atcctgtcag     2268

gtgtttggtt atattgacta tttattaata gtattagaac tcattccctg aactgatgta     2328

aatcttcata gtgtcagaca tactgaccaa aaccacaatc tagactacaa agtatattgt     2388

tttagagtac tcaaattgta ttatttatta atttttttgt ttgcaaaatc ttaacaggaa     2448

ctgtattttc tatattttaa agaattttat ttgtcccact tttactaaac agtggcagca     2508

gattttaagt taaagaatat ggaatatagt aaaataagta aatttctttt ggaatatttt     2568

tagtaacaaa tagccactat aattctgtag gccaaatttt atattgagtt tagctgtttt     2628

ctcaaaattt agcagagtgg ttaaaattct gtgctgataa gtaactgata catataacat     2688

aaacataaca aagttgccta gttgatgtaa cagtggaaag ttatctggaa atagtatttt     2748

gaactttaag ccaagtttaa aacattataa taaaaggaat accatttgtg caaaaaaaaa     2808

aaaaaaaa                                                              2816


<210>  502
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  502

Met Asp Asp Asp Leu Met Leu Ala Leu Arg Leu Gln Glu Glu Trp Asn 
1               5                   10                  15      


Leu Gln Glu Ala Glu Arg Asp His Ala Gln Glu Ser Leu Ser Leu Val 
            20                  25                  30          


Asp Ala Ser Trp Glu Leu Val Asp Pro Thr Pro Asp Leu Gln Ala Leu 
        35                  40                  45              


Phe Val Gln Phe Asn Asp Gln Phe Phe Trp Gly Gln Leu Glu Ala Val 
    50                  55                  60                  


Glu Val Lys Trp Ser Val Arg Met Thr Leu Cys Ala Gly Ile Cys Ser 
65                  70                  75                  80  


Tyr Glu Gly Lys Gly Gly Met Cys Ser Ile Arg Leu Ser Glu Pro Leu 
                85                  90                  95      


Leu Lys Leu Arg Pro Arg Lys Asp Leu Val Glu Thr Leu Leu His Glu 
            100                 105                 110         


Met Ile His Ala Tyr Leu Phe Val Thr Asn Asn Asp Lys Asp Arg Glu 
        115                 120                 125             


Gly His Gly Pro Glu Phe Cys Lys His Met His Arg Ile Asn Ser Leu 
    130                 135                 140                 


Thr Gly Ala Asn Ile Thr Val Tyr His Thr Phe His Asp Glu Val Asp 
145                 150                 155                 160 


Glu Tyr Arg Arg His Trp Trp Arg Cys Asn Gly Pro Cys Gln His Arg 
                165                 170                 175     


Pro Pro Tyr Tyr Gly Tyr Val Lys Arg Ala Thr Asn Arg Glu Pro Ser 
            180                 185                 190         


Ala His Asp Tyr Trp Trp Ala Glu His Gln Lys Thr Cys Gly Gly Thr 
        195                 200                 205             


Tyr Ile Lys Ile Lys Glu Pro Glu Asn Tyr Ser Lys Lys Gly Lys Gly 
    210                 215                 220                 


Lys Ala Lys Leu Gly Lys Glu Pro Val Leu Ala Ala Glu Asn Lys Asp 
225                 230                 235                 240 


Lys Pro Asn Arg Gly Glu Ala Gln Leu Val Ile Pro Phe Ser Gly Lys 
                245                 250                 255     


Gly Tyr Val Leu Gly Glu Thr Ser Asn Leu Pro Ser Pro Gly Lys Leu 
            260                 265                 270         


Ile Thr Ser His Ala Ile Asn Lys Thr Gln Asp Leu Leu Asn Gln Asn 
        275                 280                 285             


His Ser Ala Asn Ala Val Arg Pro Asn Ser Lys Ile Lys Val Lys Phe 
    290                 295                 300                 


Glu Gln Asn Gly Ser Ser Lys Asn Ser His Leu Val Ser Pro Ala Val 
305                 310                 315                 320 


Ser Asn Ser His Gln Asn Val Leu Ser Asn Tyr Phe Pro Arg Val Ser 
                325                 330                 335     


Phe Ala Asn Gln Lys Ala Phe Arg Gly Val Asn Gly Ser Pro Arg Ile 
            340                 345                 350         


Ser Val Thr Val Gly Asn Ile Pro Lys Asn Ser Val Ser Ser Ser Ser 
        355                 360                 365             


Gln Arg Arg Val Ser Ser Ser Lys Ile Ser Leu Arg Asn Ser Ser Lys 
    370                 375                 380                 


Val Thr Glu Ser Ala Ser Val Met Pro Ser Gln Asp Val Ser Gly Ser 
385                 390                 395                 400 


Glu Asp Thr Phe Pro Asn Lys Arg Pro Arg Leu Glu Asp Lys Thr Val 
                405                 410                 415     


Phe Asp Asn Phe Phe Ile Lys Lys Glu Gln Ile Lys Ser Ser Gly Asn 
            420                 425                 430         


Asp Pro Lys Tyr Ser Thr Thr Thr Ala Gln Asn Ser Ser Ser Ser Ser 
        435                 440                 445             


Ser Gln Ser Lys Met Val Asn Cys Pro Val Cys Gln Asn Glu Val Leu 
    450                 455                 460                 


Glu Ser Gln Ile Asn Glu His Leu Asp Trp Cys Leu Glu Gly Asp Ser 
465                 470                 475                 480 


Ile Lys Val Lys Ser Glu Glu Ser Leu 
                485                 


<210>  503
<211>  5475
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (177)..(3068)

<400>  503
caatgccggc gttcgggagg cgcaacgtcg gcggtcgctg agtatccagc ccgcagcagt       60

gacggccggc aggagcgtgc tcttccccgc ggctcgtgct ctccaggagt ccggagcatg      120

gtcctgggtc accgttggtg tagcgtgttg gtggaacgtg gacgcctaga gggagg atg      179
                                                              Met         
                                                              1           

gtg ggc tgt ggg gtg gca gtt tta tgt ttg tgg gtt tcc tgc ggc gct        227
Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly Ala           
            5                   10                  15                    

gca gcg gga cag ctc gag tac tca gtg ccg gag gag acg gag cgg ggc        275
Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg Gly           
        20                  25                  30                        

gta gcc gta ggc aat ctc tcc gcg gac ttg agg ctg cca gcg gcc gct        323
Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala Ala           
    35                  40                  45                            

atg tcc tcg cgg aac ttt cgc ttc ctt tcc agc cac cgc gag ctc tac        371
Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu Tyr           
50                  55                  60                  65            

ttc ggg gtg gat cta ccc agc ggc aat ttg gtg gtc aga gag ccg gcg        419
Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro Ala           
                70                  75                  80                

gac cgc gaa cag ctg tgc agg gcc aaa gct gcc tgc gtc ttg acc tac        467
Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr Tyr           
            85                  90                  95                    

gac ctg gtg ctc gag gac ccg ctg gag ctg cac aag att cgg att cac        515
Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile His           
        100                 105                 110                       

gtc ctg gac acc aat gac aac tca cct ctc ttt cct gcc ggc gac gtg        563
Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp Val           
    115                 120                 125                           

cag ctg cac atc ccc gag ttc ctg acg ccc gga gcc cgc ttt act ctc        611
Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr Leu           
130                 135                 140                 145           

ccg aat gcc caa gat gac gac gag gga agc aat ggg ata cta agc tac        659
Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser Tyr           
                150                 155                 160               

agc cta agc ccc agt cag cac ttt cgc ctg gac atg gga tcg cgg gtt        707
Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg Val           
            165                 170                 175                   

gac ggc agc gaa tac ccg gag ttg gtg ttg gag aaa gca ctg gat cgc        755
Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp Arg           
        180                 185                 190                       

gaa cag cgc gcc acc cac ctg ctg gtg ctt aca gct cgg gac ggc ggg        803
Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly Gly           
    195                 200                 205                           

cta cct gcc cgc tca gga gac gca caa gtc acc atc att gtg gtg gac        851
Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val Asp           
210                 215                 220                 225           

aca aat gac aac gcg cct gta ttt gag cgc tcc gta tac cgc acc aag        899
Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr Lys           
                230                 235                 240               

gtt cca gag act gca ccc aat ggg act gtg tta ttc cga gtt caa gcc        947
Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln Ala           
            245                 250                 255                   

ttg gat cca gat gaa ggg tcc aat ggg gaa gtc cag tac tcc cta agc        995
Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu Ser           
        260                 265                 270                       

aac agc acg caa gca gag ctg cga cac cgc ttt cac gtg cac cct aaa       1043
Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro Lys           
    275                 280                 285                           

agt ggg gag gtg caa gta gct gct tca cta ggt ccg cct gaa acg ctc       1091
Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr Leu           
290                 295                 300                 305           

ttg gag gca tac att gag gcg agg gac gaa ggt gtc ttt ggt tta gct       1139
Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu Ala           
                310                 315                 320               

agc acc gct aaa ctg ctg gtg gag gtg act gac gtg aac gat cat gcc       1187
Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His Ala           
            325                 330                 335                   

ccc gaa ctg gac ttc ctg act ctt tcg aac cca gta cct gag gac gct       1235
Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp Ala           
        340                 345                 350                       

gcc cct ggc aca gtg att gct ctc ttt agt gta aag gat gaa gac ctc       1283
Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp Leu           
    355                 360                 365                           

gat tct aat ggt agg gtc att tgt ggc atg tct agt gca ggc cct ttt       1331
Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro Phe           
370                 375                 380                 385           

cag ctg acg gct tcc ttt gac aac tac tac agc ctg ctg att gat ggg       1379
Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp Gly           
                390                 395                 400               

ccc ctg gac cgg gag cag atc agt gaa tac caa gtc ctg atc acg gcc       1427
Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr Ala           
            405                 410                 415                   

tca gat agt ggc tca ccc cca ctt agc acc cga agg aca atc act gtg       1475
Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr Val           
        420                 425                 430                       

tca gtt gct gat gtg aat gac aat aca cca aac ttt cct caa ccc cag       1523
Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro Gln           
    435                 440                 445                           

cag gaa ctt ttc gtt gct gaa aac aat ggc cct ggg gcc tct cta ggc       1571
Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Ala Ser Leu Gly           
450                 455                 460                 465           

cga gtg ttt gcc cag gac ccc gac ctg ggg aag aat ggc ctt gtc tct       1619
Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val Ser           
                470                 475                 480               

tat gag ctg ttg gat gtt atc tct gaa ggg cca tca gcc tct agc ttg       1667
Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser Leu           
            485                 490                 495                   

ctg gca gtg gaa tca tcc agt ggg gcc atc act gcc aaa act tcc ttt       1715
Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser Phe           
        500                 505                 510                       

gac ttt gag cag ctc agg ggg ttt cat ttc caa gta gaa ggc cgg gat       1763
Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg Asp           
    515                 520                 525                           

ggt ggc att cct ccc aga agt gca aca gtg act ata aac ttg ttt gtg       1811
Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe Val           
530                 535                 540                 545           

gta gat agg aat gac aat tat ccg gtt atc ttg ttt ccc ttg ccc aga       1859
Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro Arg           
                550                 555                 560               

aat ggt tct gtc cca gtg gaa att gtg ccc cgc tct gcc agg act gga       1907
Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr Gly           
            565                 570                 575                   

cac ttg gtc aca aaa gtg gta gca gag gat gct gac agt ggt tct aat       1955
His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser Asn           
        580                 585                 590                       

gcc tgg ctt tcc tac cac atc tcc cgg gcg tct gac tct agt ctc ttt       2003
Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu Phe           
    595                 600                 605                           

aga att tca gcc aat ata ggt gag ctc cgt act gct cgc tta gtt ctt       2051
Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val Leu           
610                 615                 620                 625           

ccc act gat gca gtt aag cag agg gtg gtg gta gtg gtt cgg gac cat       2099
Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp His           
                630                 635                 640               

gga gac cca cca ctt tcc tcc tct gtc act ctg ggt gtg ctg ttg agc       2147
Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu Ser           
            645                 650                 655                   

aac tct gtc cct cag tta ctt cca gac ttt gaa gat gtc tgg gaa cca       2195
Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu Pro           
        660                 665                 670                       

gga ggg cag ctt tct gcc cag aac ttg tat tta gta att gcc ttg gct       2243
Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu Ala           
    675                 680                 685                           

tgt att tcc ttt tta ttt ctg ggg tgc tta ctt ttc ttc gtg tgt acc       2291
Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys Thr           
690                 695                 700                 705           

aag ttg cac cag agc cca ggc tgt tgc gct cag agc tgc tgt cgc tct       2339
Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg Ser           
                710                 715                 720               

aca gag gat ctg agg tat gga agt aag atg gtt tca aat cct tgc atg       2387
Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys Met           
            725                 730                 735                   

aca tca gcc acc ata gat gtc act aca gtt gag aga ctt tct cag act       2435
Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln Thr           
        740                 745                 750                       

tat ctc tat cgg gcc tct ctg gga ctt ggt tct gat aat aac agt ttg       2483
Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser Leu           
    755                 760                 765                           

ctg ttg cgt ggg gag tac aat gct gcc gac ctg cga aat ctt gcc act       2531
Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala Thr           
770                 775                 780                 785           

ggg gta gga ctg aat ttg cca ata tcc tgt att cag att cgg aat agg       2579
Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn Arg           
                790                 795                 800               

aaa ggg gat cac gct aat gtc aat gcc atg cca cga cag ccc aac cct       2627
Lys Gly Asp His Ala Asn Val Asn Ala Met Pro Arg Gln Pro Asn Pro           
            805                 810                 815                   

gac tgg cgt tac tct gcc tcc ctg aga gca ggc atg cac agc tct gtg       2675
Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val           
        820                 825                 830                       

cac cta gag gag gct ggc att cta cgg gct ggt cca gga ggg cct gat       2723
His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp           
    835                 840                 845                           

cag cag tgg cca aca gta tcc agt gca aca cca gaa cca gag gca gga       2771
Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly           
850                 855                 860                 865           

gaa gtg tcc cct cca gtc ggt gcg ggt gtc aac agc aac agc tgg acc       2819
Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr           
                870                 875                 880               

ttt aaa tac gga cca ggc aac ccc aaa caa tcc ggt ccc ggt gag ttg       2867
Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu           
            885                 890                 895                   

ccc gac aaa ttc att atc cca gga tct cct gca atc atc tcc atc cgg       2915
Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg           
        900                 905                 910                       

cag gag cct act aac agc caa att gac aaa agt gac ttc ata acc ttc       2963
Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe           
    915                 920                 925                           

ggc aaa aag gag gag acc aag aaa aag aag aaa aag aag aag ggt aac       3011
Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn           
930                 935                 940                 945           

aag acc cag gag aaa aaa gag aaa ggg aac agc acg act gac aac agt       3059
Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser           
                950                 955                 960               

gac cag tga ggtcctcaaa tggaaacaag ccacttagcc agtttttgta               3108
Asp Gln                                                                   
                                                                          

ataatggcaa atctctccca tgtagcaatt ccctgctcct ttttcctatc tacatgagcc     3168

ctcttagaga cctcagaaat ctgcagaaag ttccctgtgt ctgtctagaa cgcatttaac     3228

aggttttgtc gtaaaagctt tactaagtct ggtgttaact ctttctctcc actctggctt     3288

gttttcagaa cctaaaaagc agacccaagt ttcctttctc ctccgccgca aaggagaggc     3348

ttcccagccc cgccagtgag aggttggact ctctgccctg tgctccgggg atcctgtctt     3408

gatgacactt gcagggcagg ctgaaaagtt ttgagattga gcagcttggg agtttgtggc     3468

cactgggtat gtgtggctac cgcgggtatg cgagtgccag atattggctg agacgagcca     3528

gcttagacta attggtacaa ggaaggcaag aaaacaaaga caaataaaca gcggaagtta     3588

tcagtatgga ggggaagtgt aaacttaaag ggaccagact ttctaaatct tacaactcaa     3648

gaggtggcag ccaccctcta ggagacaaaa ctacccccac tgacaaggct ttaggagacc     3708

ctaaagtctg ttggctgtga cgtcattata cctaaaatct gcatcatacc tgcaagccaa     3768

cagttcagtg ttttaacaga gaaccaccct gggaaacaga agcagatctg atgtgtttcc     3828

tatacatgtc ctgtgctcac tttattaaaa attcttttgc acacaatgtt tatgaaaagg     3888

ccagatcctt ttccaatact tatgcaaaag caaaagaaaa ccccgacacc tcacctttcg     3948

ctgtttgttg tttcatagat ttatttaaaa aaagagaaag tctatagcta taaatcttta     4008

aagagaaata tgaatacaat tcccctaaac tctcctcaaa agagaattca gtctacagcc     4068

atttaaatga tcattgctgc tacagaagtg ctttaagaga attgcctgaa acatctgtat     4128

tatatcggcc acctgccaat cacagcttta ctctttcagg tcactctggg gctgcctctt     4188

gcatgtatta ctaaataaaa tgatctctct ttctctctct ctctctcttt tctaagaaac     4248

aattatgtgc actttgatac acaaccttct ctaaccaact atatatcaag acccaaaaat     4308

tgaagaaaaa tattgttttc tcatacagtg agcagatttt tcaatctact aattctgtga     4368

cttgtcttgg tgtgctagcc tacaccttct ctttggttta gttttccttt tctataacac     4428

tctgaattgc taatcttact aacacctatg atgttacctg aaatcaatct cccatatgta     4488

tgctgtatgc tatgctaaga ctcctgaaat atacttactc tgtgcttgtg tatgtgaatg     4548

ttaatgcaac tattacctag agtgaacttt aagctttatt gttgaatgta attccattat     4608

atttcctttt gtacacctgt gaaaaagtgg agtagtgttt ttttaaccat tgttaatcag     4668

cttttgtgta tgaaagacac agtaaaattt ctttcttaaa tcaagatact ggtgattcaa     4728

ggaattttat ttatggtcca gccaagagcc atctcgtgcc aagacttctg ctggcaaggg     4788

aatggataaa gctgttttgt tctagtaaca attttggaat gaatactgac aatattccat     4848

gagggtgtgc aagcacaaat tttaccaatc tgacctcttt gaagttgcag aatgctttga     4908

aattctaatg gtatctgaaa tatcagctca tagaaagtaa caaaatttgc tgtcacctta     4968

aataagacat tttaattttg ttataatgta caatttagaa gtttgattaa ttatattatc     5028

tatttaggca ttaatataaa agaggtagga gtctgttatt taaaaaaagc attaaattta     5088

aaaaaaaact gtcttgtcta cttttagctt cattctccca tattttgaag ggtgtgtaac     5148

ttcagctctg caggattgca tggggtaaaa cttgttacca acacatgtga accattgcta     5208

cattgtaggt tgtgatcatt ttgccccact gaagcccatg tatctgacct tacgtgcctt     5268

ttgaactagg agaatcgggc taatttatta atgatgataa ttataatgta tctgtacagc     5328

actttttaca tttgcgaagt gctttccaat ccatgttagt tactagttat tacagctgta     5388

aggataaaac acgtcatgtg gattcatttt gaattggtgc tattggtatt tcctctgtta     5448

ttgctaataa atgaaaatgg tggtatg                                         5475


<210>  504
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  504

Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg 
            20                  25                  30          


Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala 
        35                  40                  45              


Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu 
    50                  55                  60                  


Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro 
65                  70                  75                  80  


Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr 
                85                  90                  95      


Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile 
            100                 105                 110         


His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp 
        115                 120                 125             


Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr 
    130                 135                 140                 


Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser 
145                 150                 155                 160 


Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg 
                165                 170                 175     


Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp 
            180                 185                 190         


Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly 
        195                 200                 205             


Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val 
    210                 215                 220                 


Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr 
225                 230                 235                 240 


Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln 
                245                 250                 255     


Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu 
            260                 265                 270         


Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro 
        275                 280                 285             


Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr 
    290                 295                 300                 


Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu 
305                 310                 315                 320 


Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His 
                325                 330                 335     


Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp 
            340                 345                 350         


Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp 
        355                 360                 365             


Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro 
    370                 375                 380                 


Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp 
385                 390                 395                 400 


Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr 
                405                 410                 415     


Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr 
            420                 425                 430         


Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro 
        435                 440                 445             


Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Ala Ser Leu 
    450                 455                 460                 


Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val 
465                 470                 475                 480 


Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser 
                485                 490                 495     


Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser 
            500                 505                 510         


Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg 
        515                 520                 525             


Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe 
    530                 535                 540                 


Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro 
545                 550                 555                 560 


Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr 
                565                 570                 575     


Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser 
            580                 585                 590         


Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu 
        595                 600                 605             


Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val 
    610                 615                 620                 


Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp 
625                 630                 635                 640 


His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu 
                645                 650                 655     


Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu 
            660                 665                 670         


Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu 
        675                 680                 685             


Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys 
    690                 695                 700                 


Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg 
705                 710                 715                 720 


Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys 
                725                 730                 735     


Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln 
            740                 745                 750         


Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser 
        755                 760                 765             


Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala 
    770                 775                 780                 


Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn 
785                 790                 795                 800 


Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Pro Arg Gln Pro Asn 
                805                 810                 815     


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
            820                 825                 830         


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
        835                 840                 845             


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
    850                 855                 860                 


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
865                 870                 875                 880 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu 
                885                 890                 895     


Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile 
            900                 905                 910         


Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr 
        915                 920                 925             


Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly 
    930                 935                 940                 


Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn 
945                 950                 955                 960 


Ser Asp Gln 
            


<210>  505
<211>  14239
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1553)..(5920)

<400>  505
tgcaacggaa acttttggct ccacgaacag aaaagcaaga gcaaaaactc agttaaatgc       60

gttcttcctc catctttgcc tagtccaaaa ggaaaaaaaa agaaacagaa aaaagaaaaa      120

ctgtttggaa gagtagcgtt gaggtttgct ttttacctgt ttttcctcta gaacagccag      180

gtggattcac atgatccaat tttttaattg tcttctatgt cccactccga ataacccgga      240

tgccccagca caatcagaga gatcgttttt tttaaaaaaa atttcagcct ccaaaggtag      300

gaggggagtg ttaggggaga aagtacttta attaaaaatc aataactcga ggtttttggg      360

atacggtttg ccatttccta attaagaaat gggtttgaca gtccctttgt acacactgct      420

atgcaaaccc caaagggttg gcggctgtcc gggcgatgac actccggtcc cctgcgagac      480

cccgggccag ccaggcccgt ccgccgccgg cctctggggt ccgtccccgg ctcgcgcaga      540

cctctcgctt ctctcggctc tgtctcctgc gctcagctct gctcggggcc ggccgcctca      600

ggctcgccgc caccaggtcg ttgcaaatac cttttccctc cccggggccc cagcgcgcgg      660

ccacctccca gcctcccccc ctcccaccct ggcagcgggg ccctttcccg gctcaggaac      720

agcagcagcc cgggccgcgc cggcaggaag cgaggcccat gttgctgctg ttccctggcg      780

cgcctccccg ccctccgggg gccgccacgg ctcttccgcg ctcccgggca cccccctccg      840

cgcctgcgct gtgccccacg ggggcggggc tcagattcct gtcagcggcg gcggcggtgg      900

cggcgaccgt cagttttcgc tgaggagaaa cacgaaacgg accctttggc tctccccctt      960

ccccttcccc gtcctgaacc cctctcctgg tcaccgagaa tcagtccccg tggagttccc     1020

cctccacctc gccatcgttt cctcggtcct cggcccagtg gaagtcacta ccctcgagga     1080

ggaggcagcg gcagccgccc tcgcgtcgcc gcccccggtt cggtgcccgc ggtcccggag     1140

aggaggtgcc gccgccaccg ccgctccccc cctcccgctg ccctcgggcc gggctgggtc     1200

gagctgcgat gccctcggac ttcatctcat tgctcagcgc ggacctagac ctggaatcgc     1260

ccaagtccct ctactcgcga gattctctga agttacaccc atcacagaat tttcatagag     1320

ctggactatt ggaagaatct gtctatgatc ttctcccaaa ggagttacag ttacctccat     1380

ctagagaaac atctgtagca tcaatgagtc agacaagcgg tggtgaggca ggctcgcctc     1440

ctccagctgt tgttgctgct ggatttgcct ctgaagcagg gagtgtctgc attaaaaatg     1500

acctgtagtt ctctgcttca tagatgcttc ttcagctccc tcctcttcct cc atg ggc     1558
                                                          Met Gly         
                                                          1               

ggt gct tgc agc tcc ttt acc acc tct tcc agc cct acc att tat tct       1606
Gly Ala Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile Tyr Ser           
        5                   10                  15                        

acc tca gtc acc gac agc aag gct atg caa gtg gag agc tgc tcc tca       1654
Thr Ser Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys Ser Ser           
    20                  25                  30                            

gcc gtg ggg gta agt aac aga ggg gta agt gaa aag cag tta acc agt       1702
Ala Val Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu Thr Ser           
35                  40                  45                  50            

aac aca gtt cag cag cat cca tca aca ccg aag agg cac aca gtc ttg       1750
Asn Thr Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr Val Leu           
                55                  60                  65                

tac atc tca cca cca cct gag gac ttg ctg gat aac agt cgg atg tcc       1798
Tyr Ile Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg Met Ser           
            70                  75                  80                    

tgc cag gat gag ggg tgt gga ttg gaa tct gag cag agc tgc agt atg       1846
Cys Gln Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys Ser Met           
        85                  90                  95                        

tgg atg gag gat tcc ccc tcc aac ttc agt aac atg agc acc agt tcc       1894
Trp Met Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr Ser Ser           
    100                 105                 110                           

tac aat gat aac act gag gta cct cgt aaa tca cga aaa cga aat cca       1942
Tyr Asn Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg Asn Pro           
115                 120                 125                 130           

aag cag agg ccg ggg gtc aaa cga cga gat tgt gaa gaa tct aat atg       1990
Lys Gln Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser Asn Met           
                135                 140                 145               

gat ata ttt gat gcc gac agt gcc aaa gca cct cac tat gtg ctt tct       2038
Asp Ile Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val Leu Ser           
            150                 155                 160                   

cag ctt acc acg gac aac aaa ggc aac tca aaa gcg gga aat gga aca       2086
Gln Leu Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn Gly Thr           
        165                 170                 175                       

ttg gaa aac caa aaa gga act gga gta aag aag agc cct atg ttg tgt       2134
Leu Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met Leu Cys           
    180                 185                 190                           

gga caa tat cct gtt aaa agt gag gga aag gag ctg aag ata gtt gta       2182
Gly Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile Val Val           
195                 200                 205                 210           

caa cct gag aca cag cac cga gct cgg tac ctg act gag ggc agc cgt       2230
Gln Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly Ser Arg           
                215                 220                 225               

ggc tca gtg aaa gat aga aca cag caa ggc ttt cct aca gta aag ctg       2278
Gly Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val Lys Leu           
            230                 235                 240                   

gaa ggc cat aat gaa cct gta gtg ttg caa gtg ttt gtg ggc aac gac       2326
Glu Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly Asn Asp           
        245                 250                 255                       

tct gga cga gtg aaa cca cat gga ttt tat cag gcc tgc aga gta act       2374
Ser Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg Val Thr           
    260                 265                 270                           

gga cga aat aca act cct tgc aaa gaa gtg gac att gaa ggc act act       2422
Gly Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly Thr Thr           
275                 280                 285                 290           

gtt ata gaa gtc ggc ctt gat cct agc aac aac atg aca ctg gcg gtg       2470
Val Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu Ala Val           
                295                 300                 305               

gac tgc gta ggg ata ttg aaa ttg agg aat gct gat gtc gaa gcc aga       2518
Asp Cys Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu Ala Arg           
            310                 315                 320                   

ata gga att gct ggt tcc aag aag aaa agc act cgt gcc aga ttg gtt       2566
Ile Gly Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg Leu Val           
        325                 330                 335                       

ttt cga gtt aat atc atg agg aaa gat ggc tcc act ttg aca ctg caa       2614
Phe Arg Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr Leu Gln           
    340                 345                 350                           

aca ccc tct tct cca att ttg tgt act cag cca gca gga gtg cca gaa       2662
Thr Pro Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val Pro Glu           
355                 360                 365                 370           

atc tta aag aaa agc ttg cat agc tgt tca gtg aaa gga gaa gaa gaa       2710
Ile Leu Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu Glu Glu           
                375                 380                 385               

gtg ttt tta atc ggc aag aac ttt ctg aaa gga act aaa gtt att ttc       2758
Val Phe Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val Ile Phe           
            390                 395                 400                   

caa gaa aat gtt tct gat gaa aac tct tgg aag tca gaa gct gaa att       2806
Gln Glu Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala Glu Ile           
        405                 410                 415                       

gat atg gaa cta ttt cat cag aat cat ctt att gtg aag gtt cct ccc       2854
Asp Met Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val Pro Pro           
    420                 425                 430                           

tat cat gac caa cat ata act ttg cct gtg tca gtg gga ata tat gta       2902
Tyr His Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile Tyr Val           
435                 440                 445                 450           

gtg aca aat gct gga aga tct cat gat gtt caa cca ttc act tac act       2950
Val Thr Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr Tyr Thr           
                455                 460                 465               

cca gac cca gca gca gct ggt gct ttg aat gta aat gtg aag aag gaa       2998
Pro Asp Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys Lys Glu           
            470                 475                 480                   

ata tct agt cca gca aga cct tgc tct ttt gaa gag gcc atg aaa gca       3046
Ile Ser Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met Lys Ala           
        485                 490                 495                       

atg aaa act act gga tgt aat tta gat aag gta aat att atc cct aat       3094
Met Lys Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile Pro Asn           
    500                 505                 510                           

gcc ctg atg act cca ctc ata cca agc agt atg att aag agt gaa gat       3142
Ala Leu Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser Glu Asp           
515                 520                 525                 530           

gtt act cca atg gaa gta aca gca gaa aaa aga tct tcc act att ttt       3190
Val Thr Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr Ile Phe           
                535                 540                 545               

aag act aca aag tct gtt gga tca act cag caa aca tta gaa aac atc       3238
Lys Thr Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu Asn Ile           
            550                 555                 560                   

tca aac ata gca gga aat ggc tct ttt tca tca cca tca tct tcc cac       3286
Ser Asn Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser Ser His           
        565                 570                 575                       

cta cct tct gaa aat gaa aaa cag cag cag att cag ccc aag gca tac       3334
Leu Pro Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys Ala Tyr           
    580                 585                 590                           

aac cca gag acc ctg aca act att caa acc cag gac atc tca cag cct       3382
Asn Pro Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser Gln Pro           
595                 600                 605                 610           

ggt act ttt cca gca gtt tct gct tct agt cag ctg ccc aac agc gat       3430
Gly Thr Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn Ser Asp           
                615                 620                 625               

gca cta ttg cag cag gct aca cag ttt cag aca aga gaa act cag tct       3478
Ala Leu Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr Gln Ser           
            630                 635                 640                   

aga gag ata tta cag tca gat ggt aca gtg gtt aat ttg tca caa ctg       3526
Arg Glu Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser Gln Leu           
        645                 650                 655                       

act gag gca tca caa caa cag cag cag tca cca cta caa gaa caa gca       3574
Thr Glu Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu Gln Ala           
    660                 665                 670                           

cag act tta cag cag cag att tca tca aat att ttt cca tca cca aat       3622
Gln Thr Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser Pro Asn           
675                 680                 685                 690           

agt gtg agt cag ctt cag aat act att cag cag ctg caa gca ggg agt       3670
Ser Val Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala Gly Ser           
                695                 700                 705               

ttc aca ggc agt act gct agt ggc agc agt gga agt gtt gac ttg gtc       3718
Phe Thr Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp Leu Val           
            710                 715                 720                   

caa caa gtt tta gag gca cag cag cag tta tct tca gtt tta ttt tct       3766
Gln Gln Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu Phe Ser           
        725                 730                 735                       

gct cca gat ggt aat gag aat gtt caa gag cag ctt agt gca gat att       3814
Ala Pro Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala Asp Ile           
    740                 745                 750                           

ttt caa caa gtc agt caa att cag agt ggt gta agc cct gga atg ttt       3862
Phe Gln Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly Met Phe           
755                 760                 765                 770           

tcc tca aca gag cca aca gtc cat acc aga cca gat aat tta tta cct       3910
Ser Ser Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu Leu Pro           
                775                 780                 785               

gga aga gct gaa agt gtt cat cca cag tct gaa aac acg tta tct aat       3958
Gly Arg Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu Ser Asn           
            790                 795                 800                   

caa cag cag cag cag cag cag caa cag caa gtg atg gaa tct tca gcc       4006
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser Ser Ala           
        805                 810                 815                       

gca atg gtg atg gag atg caa cag agt atc tgc cag gca gct gcc cag       4054
Ala Met Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala Ala Gln           
    820                 825                 830                           

att cag tca gag tta ttc cct tca act gct tca gca aat gga aac ctt       4102
Ile Gln Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly Asn Leu           
835                 840                 845                 850           

cag caa tcg cca gtt tac cag cag act tct cac atg atg agt gca ttg       4150
Gln Gln Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser Ala Leu           
                855                 860                 865               

tct acc aat gag gat atg caa atg cag tgt gaa ttg ttt tct tct cct       4198
Ser Thr Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser Ser Pro           
            870                 875                 880                   

cct gca gtt tct gga aat gaa act tct aca act acc aca cag cag gtt       4246
Pro Ala Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln Gln Val           
        885                 890                 895                       

gca acc cct ggc act acc atg ttt cag aca tca agt tca gga gat gga       4294
Ala Thr Pro Gly Thr Thr Met Phe Gln Thr Ser Ser Ser Gly Asp Gly           
    900                 905                 910                           

gaa gaa act gga aca caa gca aaa cag att cag aac agt gtc ttt cag       4342
Glu Glu Thr Gly Thr Gln Ala Lys Gln Ile Gln Asn Ser Val Phe Gln           
915                 920                 925                 930           

acc atg gtc caa atg caa cat agt ggg gac aat caa cct caa gtt aac       4390
Thr Met Val Gln Met Gln His Ser Gly Asp Asn Gln Pro Gln Val Asn           
                935                 940                 945               

ctt ttt tca tcc aca aaa agt atg atg agt gtt cag aat agt ggt acc       4438
Leu Phe Ser Ser Thr Lys Ser Met Met Ser Val Gln Asn Ser Gly Thr           
            950                 955                 960                   

caa caa caa ggt aat ggt tta ttc cag caa ggg aat gag atg atg tca       4486
Gln Gln Gln Gly Asn Gly Leu Phe Gln Gln Gly Asn Glu Met Met Ser           
        965                 970                 975                       

ctt caa tct gga aat ttt ttg cag cag tct tct cat tca cag gcc caa       4534
Leu Gln Ser Gly Asn Phe Leu Gln Gln Ser Ser His Ser Gln Ala Gln           
    980                 985                 990                           

ctt ttt cat cct caa aat  cct att gcc gat gct  cag aac ctt tcc         4579
Leu Phe His Pro Gln Asn  Pro Ile Ala Asp Ala  Gln Asn Leu Ser             
995                 1000                 1005                             

cag  gaa act caa ggt tct  ctc ttt cat agt cca  aat cct att gtc        4624
Gln  Glu Thr Gln Gly Ser  Leu Phe His Ser Pro  Asn Pro Ile Val            
1010                 1015                 1020                            

cac  agt cag act tct aca  acc tcc tct gaa caa  atg cag cct cca        4669
His  Ser Gln Thr Ser Thr  Thr Ser Ser Glu Gln  Met Gln Pro Pro            
1025                 1030                 1035                            

atg  ttt cac tct caa agt  acc att gct gtg tta  cag ggc tct tca        4714
Met  Phe His Ser Gln Ser  Thr Ile Ala Val Leu  Gln Gly Ser Ser            
1040                 1045                 1050                            

gtt  cct caa gac cag cag  tca acc aac ata ttt  ctt tcc cag agt        4759
Val  Pro Gln Asp Gln Gln  Ser Thr Asn Ile Phe  Leu Ser Gln Ser            
1055                 1060                 1065                            

ccc  atg aat aat ctt cag  act aac aca gta gcc  caa gaa gca ttt        4804
Pro  Met Asn Asn Leu Gln  Thr Asn Thr Val Ala  Gln Glu Ala Phe            
1070                 1075                 1080                            

ttt  gca gca ccg aac tca  att tct cca ctt cag  tca aca tca aac        4849
Phe  Ala Ala Pro Asn Ser  Ile Ser Pro Leu Gln  Ser Thr Ser Asn            
1085                 1090                 1095                            

agt  gaa caa caa gct gct  ttc caa cag caa gct  cca ata tca cac        4894
Ser  Glu Gln Gln Ala Ala  Phe Gln Gln Gln Ala  Pro Ile Ser His            
1100                 1105                 1110                            

atc  cag act cct atg ctt  tcc caa gaa cag gca  caa ccc ccg cag        4939
Ile  Gln Thr Pro Met Leu  Ser Gln Glu Gln Ala  Gln Pro Pro Gln            
1115                 1120                 1125                            

cag  ggt tta ttt cag cct  cag gtg gcc ctg ggc  tcc ctt cca cct        4984
Gln  Gly Leu Phe Gln Pro  Gln Val Ala Leu Gly  Ser Leu Pro Pro            
1130                 1135                 1140                            

aat  cca atg cct caa agc  caa caa gga acc atg  ttc cag tca cag        5029
Asn  Pro Met Pro Gln Ser  Gln Gln Gly Thr Met  Phe Gln Ser Gln            
1145                 1150                 1155                            

cac  tca ata gtt gcc atg  cag agt aac tct cca  tcc cag gaa cag        5074
His  Ser Ile Val Ala Met  Gln Ser Asn Ser Pro  Ser Gln Glu Gln            
1160                 1165                 1170                            

cag  cag cag cag caa cag  cag cag caa cag cag  cag caa caa caa        5119
Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln            
1175                 1180                 1185                            

cag  agc att tta ttc agt  aat cag aat acc atg  gct aca atg gcg        5164
Gln  Ser Ile Leu Phe Ser  Asn Gln Asn Thr Met  Ala Thr Met Ala            
1190                 1195                 1200                            

tct  cca aag caa cca cca  cca aac atg ata ttc  aac cca aat caa        5209
Ser  Pro Lys Gln Pro Pro  Pro Asn Met Ile Phe  Asn Pro Asn Gln            
1205                 1210                 1215                            

aat  cca atg gct aat cag  gag caa cag aac cag  tca att ttt cac        5254
Asn  Pro Met Ala Asn Gln  Glu Gln Gln Asn Gln  Ser Ile Phe His            
1220                 1225                 1230                            

caa  caa agt aac atg gcc  cca atg aat caa gag  caa cag ccc atg        5299
Gln  Gln Ser Asn Met Ala  Pro Met Asn Gln Glu  Gln Gln Pro Met            
1235                 1240                 1245                            

caa  ttt cag agt cag tcc  aca gtt tcc tca ctt  cag aac cca ggt        5344
Gln  Phe Gln Ser Gln Ser  Thr Val Ser Ser Leu  Gln Asn Pro Gly            
1250                 1255                 1260                            

cct  acc cag tcg gaa tca  tca cag acc ccc ttg  ttc cat agc tct        5389
Pro  Thr Gln Ser Glu Ser  Ser Gln Thr Pro Leu  Phe His Ser Ser            
1265                 1270                 1275                            

cct  cag att cag ttg gta  caa ggg tca cct agt  tct caa gag cag        5434
Pro  Gln Ile Gln Leu Val  Gln Gly Ser Pro Ser  Ser Gln Glu Gln            
1280                 1285                 1290                            

caa  gta act ctc ttc tta  tct cca gca tcc atg  tct gcc ttg cag        5479
Gln  Val Thr Leu Phe Leu  Ser Pro Ala Ser Met  Ser Ala Leu Gln            
1295                 1300                 1305                            

acc  agt ata aat caa caa  gat atg caa cag tct  cct ctt tat tcc        5524
Thr  Ser Ile Asn Gln Gln  Asp Met Gln Gln Ser  Pro Leu Tyr Ser            
1310                 1315                 1320                            

cct  cag aac aac atg cct  gga att caa gga gcc  aca tct tcg cct        5569
Pro  Gln Asn Asn Met Pro  Gly Ile Gln Gly Ala  Thr Ser Ser Pro            
1325                 1330                 1335                            

caa  cca cag gct act tta  ttt cac aac aca gca  gga ggc aca atg        5614
Gln  Pro Gln Ala Thr Leu  Phe His Asn Thr Ala  Gly Gly Thr Met            
1340                 1345                 1350                            

aac  caa ctg cag aat tct  cct ggc tca tct cag  cag aca tca gga        5659
Asn  Gln Leu Gln Asn Ser  Pro Gly Ser Ser Gln  Gln Thr Ser Gly            
1355                 1360                 1365                            

atg  ttc tta ttt ggc att  caa aat aac tgt agt  cag ctt tta acc        5704
Met  Phe Leu Phe Gly Ile  Gln Asn Asn Cys Ser  Gln Leu Leu Thr            
1370                 1375                 1380                            

tct  gga cca gct aca ttg  cct gat cag ttg atg  gcc ata agt cag        5749
Ser  Gly Pro Ala Thr Leu  Pro Asp Gln Leu Met  Ala Ile Ser Gln            
1385                 1390                 1395                            

cca  ggc caa cca caa aac  gag ggc cag cca cct  gtg aca aca ctt        5794
Pro  Gly Gln Pro Gln Asn  Glu Gly Gln Pro Pro  Val Thr Thr Leu            
1400                 1405                 1410                            

ctt  tct cag caa atg cca  gag aat tct cca ctg  gca tcc tct ata        5839
Leu  Ser Gln Gln Met Pro  Glu Asn Ser Pro Leu  Ala Ser Ser Ile            
1415                 1420                 1425                            

aac  acc aac cag aac atc  gaa aag att gat ttg  ctt gtt tca ttg        5884
Asn  Thr Asn Gln Asn Ile  Glu Lys Ile Asp Leu  Leu Val Ser Leu            
1430                 1435                 1440                            

caa  aac caa ggg aac aac  ttg act ggc tcc ttt  taa ctggatataa         5930
Gln  Asn Gln Gly Asn Asn  Leu Thr Gly Ser Phe                             
1445                 1450                 1455                            

attccacgaa gaaaatcctg attccaagat gtcctgagat cttgtggttc catgagaatt     5990

attactttaa aaacaaaaca aaatataaaa aactgtgttt gagtaaactg atagatttta     6050

ctctgactgc aaaagagcac acctatgctg cttgttgcag taactaacca ccaatgttaa     6110

catcttcata ttttatattc ctaataacag tgatgactga gaatctattt gagtttccag     6170

ctggcagaat taattgttat tattttccta ggcgcaattt ccttaaacgt acagtttaaa     6230

ttcaaggctg gaccactcag ttattattgc tattagaaaa taatatatca tgtttacttt     6290

tgttcttcat tattttcttt cctgcattgt tttagtcaag taatggcttt tgaaaaagta     6350

aagttcaata ataactaagg ctgtgatttt tttcaatata aaaggcacag ctgttggcca     6410

aagtgaagga atcttttttc agttttattg gagaaactga agggtaacat tctaacaagt     6470

aaactgtatg tgcagataaa agtactcttg atttaacaca aaggcagatg atacacttat     6530

aaaactggga acagctggaa tgcttcttga ttttattttt tcagagagtt gttagttctc     6590

tgggtttcta ctaaggggtt tagccataac tgtgcataga aaaataatta tctgtaaaaa     6650

atgaagggga taatatatga taaattatgt tctgatatcc tcctacagta gtttaaattg     6710

acagaaaaat ttgaatgttt tcttcttaac ccagtcttag gctggtattc cctttttata     6770

tatatctata ttacttttca cctctttttc actttacttt agagaactat taatatacta     6830

ctggcttcat gaccctgtag catctttggc cactttaatc tagggtgacc tagcaatcct     6890

gcagcacagg gcagagagta ctgtcttagg aattattagg agttgattcc tgagaaacaa     6950

cacatttttc cccatgaacg gtgctgttct gaagtcttca aatttttccc tctaatagga     7010

aacagtataa attttaatta aaaaaaaaag gcaaactaaa atttcttgaa atatcacttc     7070

tccctgatct gcagtgagta taaattcact tgtcacctca gtgctttaca gtttgaagtg     7130

gtcacttacc tgatggttcc cacaagcctt aggctttaca gggttgtatc attgacttaa     7190

aatgaagaat taacttgtgt tacatctata aagagcaaaa taacacactc cagaacttgg     7250

cagttgtagc attagttata cagttttggg tgttcttgcc acccgtggga tgcctgcttc     7310

tcactaccac ctgtgtctgg acacatgctt atgtctcatt ttccttttgg catgtggaaa     7370

gctgtcaatg cagtgtaagg ccaacgtgtg tgtggcttct atgtgttgag ataatgtttt     7430

ggtatccttg tccgtttcat ttatttttta agtgtacaaa aaataacctg ttaattgttg     7490

aaggctactt ttctgttctt tttttttttt tttttctatc ctgtacattt agttgaactg     7550

tgcggaattg tggtgttggt tttgtttaca cagccagatt tttccttctt tttgttttgt     7610

gatgatcttc ctttgttctt tgaatgtgct cttttgtctt tttctctttt ttctcatgtt     7670

ttcttccctc cacctccacc cctttctttc tttctctctc tgattgagag gcattgaatt     7730

acgttttcag tagtacaggc ttcttgccga tatgaaggga acttttcaga aagagaccta     7790

ctctgggtca tttaattttg aatacagttt tcaatcgttc aagttttgga tggtttatat     7850

ctaatgtgtg tttcattttt ttggaaagct atattttgta tttaggaaat ggtatactat     7910

tttgctattt gtactgagtg agtacattgg cataaatata gaaatttata tatatacata     7970

tatataaact attctttttt gccacacatt tttgtggtaa atttgtgagt ttgtctgatg     8030

ttctaccaca acgtggcgtc tgataacagt gagggggggt ggggtttgtt atgtctttat     8090

tgagtattta agtatctttt gaaacaaatg acctgttcat ctgtggccat tccatcaggc     8150

agttagttcc ttgatgtcag tagtgggcta aaggcagctt actgtgtgtt tgctggagct     8210

ttcactcagc caagtgttag agtcaggaaa cccattgagg caatggcgtc aaatggtgtt     8270

tcacaagaat gagccattca gtctttgctc actatatatt taatatttta ttattgttgt     8330

tattgttatt attaattggc tttctgtatt ctatgccttt tatttataaa gacactaaga     8390

aaacccatgt ttgtaatttt aataacattt ttcccatctt gtaatatcca gagctacttt     8450

ataaattctc tgaaccaaaa gtattttcct cagtgtatct cttctccccc agcccctatt     8510

gggaaaaatt acccagtata gttcaggtta tgaggaggat cagccacaca atccagtgct     8570

tcagtttgaa aatgtaaaat tctaacccta aagtagggtt ggttgaaatt tcagacaaag     8630

caaacccagc aggtataaaa agtagtataa atacaaatct gtaagttatt tttgaatttt     8690

ctgaactttt ttctaagaga ttacatagga gactaaagaa atctatctgt tcaagttcta     8750

attaggatga ttgttaatac tgcactgtgg atgaagtggc gactggcttg tgtgctgact     8810

tctgtggttt agcaagaggt ttattgttat caaatgctaa ttggcaatgc caagtcactg     8870

ggaccaattt tctgttttat aatatctaag tttagaacag aatatatacc tgaactgtag     8930

tggtttgatc ggatggagac agaaaacccg atttttattc tcataaattt tgtggttatt     8990

tatacaaggg ctgtgctatg ctaccatatt cttgttcaat aataataggt ttgttgtttt     9050

ttttacattg ttaaatgttc cttaccccta aaggtcaatg ttaagtacaa cattctgaaa     9110

atacaatttg gctacgaaga gtattcatct tctttgaagc tcagtggttg atatttgtgc     9170

taataatgca atttcctgat tactgttaca agttatagct acatatggga gagactcagt     9230

gagccagcaa aggccataga aacaacaatt tattaaatgt atttatggca gaaggaccta     9290

aataaactgt gagccacctt ttcttcttta tattgttaca tttaagtgtt cttgctttca     9350

gcaactcaca ttaatgcttg gagcttatct ctttctctct ctctctctct ctctctgtgt     9410

gtgtgtgtgt atgtgtgtgt gtgtgtgtgt gtgtttcctt attgtcattc cattatatat     9470

ccacaccaac atgggtgacg ataattcaaa gtcatatttt gcctctaagc ttgatcatgt     9530

tacctttatg attaaagtat catgttattt agccaatgca aatctgtttt aaaacaaata     9590

gtttaaaaaa agaacaagtt tttaagggct ttattataga agaagtatta atgaaggact     9650

ttccttcctc cctccctttc ctcccctccc tgcctccctt cttcccttcc atctccccct     9710

cctccctgcc ttctttgttt ctccttccct tattcctccc tccctccttt ctcccttcct     9770

tcctttcttc cattcatcct tccttgcctt ttatttttat tttttgtaat atcacatgtg     9830

ctgtagtttg gaattttatt ctagtgcatt tcttgctcat cagaacctca gctaatctac     9890

ctaggaaaaa tagtatcaaa ggaaatgaga aagttgtatc tgagtccctc cagaactaag     9950

ataattcttt ttgaccattt aagcctttat aaatgcgttt tgaccattta agcctttata    10010

aatgcttgtt ttaggaaagt gaatctgtta gatgcatcaa caaataatga ccaggacaaa    10070

acgatttaat aattaaagtc tcaaatcacc atggttatac attttcacca gaaatagtaa    10130

tcttacaatt tttcattttt ctgatgaaga tttctgttcc aatatctgtt tcctaataga    10190

ttttttaaat taattagctt tcctctgctt tatgaccaca ggttttatcc ctaaccgaga    10250

cagctgtctt atatctgcat gccttagact gtgtggaggg actccatgaa gaaagaccat    10310

aggttagaaa aataactcat agtatatacc ctagtaagtg ggttagtaga atctcataac    10370

atgtattaaa aagaggtttt cttctctgct tgtttgtgtc actagagcaa aattgtagag    10430

ataatgctca taatgcagta aatatcagaa taatatctac aatatcattt gtggatggtc    10490

ccaggtccca gtgctctagt tactttactt cttttttttt ttttgagatg gagtcttgct    10550

ctgtctctca ggctagagca gtgtgcgatc tcagctcact gcagcctcca cctcccaggt    10610

tcaagcgatt ctcctgcctc agcctcccaa gtagccagga ttacaggcac cctccactag    10670

gcccggctaa ttttttttgt atttttttag tagagatggg gttttgccat gttggccagg    10730

ctggtttcga actcctaacc tccagtgatc cacctgcctc ggcgtcccaa agtgctagga    10790

ttacaggcat gagccaccac atccggccta attacttctt taatccccat ttatttttat    10850

gccattctag cctcatttat taataaaatt atgtttttac tttctctttc aggaaatttt    10910

ttaaattaat attttatatc tagatctaat gctatggaaa agtgcctttt tatcatttat    10970

aatttcattt ttcactattt ccaaaaacac ataaacaaat agtttcagta ggtcccagct    11030

tttacttttt ccatttaaac cttcttttct ccatttcttc cctttggctt aagaataaaa    11090

gaaaaggtac attgctagaa ttgtttcttt gggagagggt aaaagattac agaattagac    11150

tgttcagcct ttatataaac taaatttgtc ttcatctcaa ccagctaatg gtaggtctta    11210

tctgaatact catgagaatt ttagcatctg tgaaactcca tgcaccagat gtgtgtaaat    11270

ttcaggaaga aagtgttgaa agcattttct ctgatgttaa ttagatggaa ataaatcact    11330

aaaacatagt ttaggtaaag cctgattatg ccactttttt ttaactagac agggcaaagt    11390

tgtttatgtt agtgtacttc ttgtctatcc tcagttaatt tacctagaca aaaagtgtca    11450

aaggaaatga gaaaaaggtt atatctgact ccctccagac ctaagataat tccttttgat    11510

cagatacagt cagatggagt gccttggttt ttgttaattt tgcctctatt ccagctcctt    11570

accacagcgg tggtgcttaa agaaaggatc atcagcaaca ggtcaggata gttctacctt    11630

tgggataggg ctgctttccc cgtgctagta tttctgtgac tgttagtggc actgaggact    11690

gcaaactttt atgcaatatt cttaataccc tattgatatt atgcacttta atcattccaa    11750

agaagccaag aatgctgtat agtgatgatt ccttcctaat gaattcatct taactattta    11810

gaatgttatg tcccttttct tttggatagc caacttggta taaatgttat atggattttt    11870

ctaaaatgac tatataggac ttaagacttt gaaatgtaat ttacttataa ggggaaataa    11930

ttatgcttta gcacatcatt ttagaaacgt cacattttag aaacattcag cttgctaacc    11990

tacatgtttg ggaattcatt aaaaccagtt gtctatatat tttgtgccat gtatataaga    12050

acattacaat atatcttttt ctacatatgt agtatgtgca accagtggtt ctcagagtat    12110

ggttctcagc ccaccagcta gtatcagtat cacctgggaa ctagttagaa atgtaaattc    12170

tttggcccca tcccagacat actgagtcag aaactctgga atagggcccc cgcaatctgt    12230

tttcacaagc cctccaggtg attctgatgc acactttaaa gtttaggaac cactgggcta    12290

agactctgtt gagatataga gtttttcttc cactcagact gatatagtta tacattgttc    12350

ttcatgtaaa ttcagcttaa cctggttatc tataatcttt tattggcaaa agttaattct    12410

cagtactgcc tatagagata cagtgtattt tatgtacata cacaattagt ctaattcttg    12470

ataattcagt taatttagtt tggcattttc ctaccactta ctaaaaggtt tacattaaat    12530

gactgattta aatatatagg tgcaatgttc tatgtttatt ttaattgtta tgacatttaa    12590

gtagctaata taattgaccg gtgctaaagt ctcctgttta tccataaaat gggtacatta    12650

tgggcagtgt aatacaagct ttcttttcat tgcctagtac tttaccagca gaccacagtt    12710

ttgccctggc tagaccaacc ctcagaacaa aatcatcatt ccttgtattt atatttgtat    12770

ctgagatagt aaacaagatg gctggccagg tcaacatggc accttaactt atttttttaa    12830

taggtaaaac ttcttcaaaa gtagcttgct ttgtataaga actaagctat cagtatagat    12890

atagctatcc ttggagctta tgtttcagac aagaattatt tactaaaata aataataaac    12950

aagataatgc attatacaat ttgggcattt ctcgtttctc aagtgtatgc atcatggtaa    13010

atataaacta accacaagat aggtagattg attcatttca ttttaatctc cttgtgtaat    13070

tcagtacctc cataattgtt ctaatcttct tcccactgtt tacaaattac cagttaatta    13130

actcgtgaaa gaaaaattca catatcagaa taaaaataaa tgtatactca ctttataaaa    13190

atcaccactg ctgtctttcc ttaatactag cagtggaaat gtaagtggct tactctacaa    13250

attttggtgc tggcaaatac ataggcaaac tgttgggagc tgctctagtt acattcctcc    13310

cttcttattc cctttttctc ttcctcactt tattgcataa catattcctg tacccaaagc    13370

attctaccac agttctattt gactcccact tgtaataact cctttaaaaa attccatgtt    13430

taaccatatg accctgcttg cttactcata ttctccctcc ctctcccctt cctttctctc    13490

tcttccagaa gtcatttgcc tggtttgaaa tattttgtag ggattgctta ttatattatt    13550

ttagctgatg aacctcagga caacgtctac acacacacac atacatacac gcacacaaaa    13610

tctcagctgt tgaagagtgg gcttggaatc agacttctgt gtccagtaaa aaactcctgc    13670

actgaagtca ttgtgacttg agtagttaca gactgattcc agtgaacttg atctaatttc    13730

ttttgatcta atgaatgtgt ctgcttacct tgtttccttt taattgataa gctccaagta    13790

gttgctaatt ttttgacaac tttaaatgag tttcattcac ttcttttact taatgtttta    13850

agtatagtac caataatttc attaacctgt tctcaagtgg tttagctacc attctgccat    13910

ttttaatttt tatttaattt tatttgcttg agcacactga tcaaccactg aactgccttc    13970

ttccattgtc ctgcaatgat ataagggtta catttttgtg tatatggctt tcatagttgg    14030

gatttcagag cactgatacc agatattttc agtttgttct ctgggggaat ttcatttgca    14090

tctatgtttt tagctatctg tgataacttg ttaaatatta aaaagatatt ttgcttctat    14150

tggaacattt gtatactcgc aactatattt ctgtaaacag ctgcagtcaa aaataaaaca    14210

ctgaaagtta aaaaaaaaaa aaaaaaaaa                                      14239


<210>  506
<211>  1455
<212>  PRT
<213>  Homo sapiens

<400>  506

Met Gly Gly Ala Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile 
1               5                   10                  15      


Tyr Ser Thr Ser Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys 
            20                  25                  30          


Ser Ser Ala Val Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu 
        35                  40                  45              


Thr Ser Asn Thr Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr 
    50                  55                  60                  


Val Leu Tyr Ile Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg 
65                  70                  75                  80  


Met Ser Cys Gln Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys 
                85                  90                  95      


Ser Met Trp Met Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr 
            100                 105                 110         


Ser Ser Tyr Asn Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg 
        115                 120                 125             


Asn Pro Lys Gln Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser 
    130                 135                 140                 


Asn Met Asp Ile Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val 
145                 150                 155                 160 


Leu Ser Gln Leu Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn 
                165                 170                 175     


Gly Thr Leu Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met 
            180                 185                 190         


Leu Cys Gly Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile 
        195                 200                 205             


Val Val Gln Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly 
    210                 215                 220                 


Ser Arg Gly Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val 
225                 230                 235                 240 


Lys Leu Glu Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly 
                245                 250                 255     


Asn Asp Ser Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg 
            260                 265                 270         


Val Thr Gly Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly 
        275                 280                 285             


Thr Thr Val Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu 
    290                 295                 300                 


Ala Val Asp Cys Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu 
305                 310                 315                 320 


Ala Arg Ile Gly Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg 
                325                 330                 335     


Leu Val Phe Arg Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr 
            340                 345                 350         


Leu Gln Thr Pro Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val 
        355                 360                 365             


Pro Glu Ile Leu Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu 
    370                 375                 380                 


Glu Glu Val Phe Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val 
385                 390                 395                 400 


Ile Phe Gln Glu Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala 
                405                 410                 415     


Glu Ile Asp Met Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val 
            420                 425                 430         


Pro Pro Tyr His Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile 
        435                 440                 445             


Tyr Val Val Thr Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr 
    450                 455                 460                 


Tyr Thr Pro Asp Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys 
465                 470                 475                 480 


Lys Glu Ile Ser Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met 
                485                 490                 495     


Lys Ala Met Lys Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile 
            500                 505                 510         


Pro Asn Ala Leu Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser 
        515                 520                 525             


Glu Asp Val Thr Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr 
    530                 535                 540                 


Ile Phe Lys Thr Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu 
545                 550                 555                 560 


Asn Ile Ser Asn Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser 
                565                 570                 575     


Ser His Leu Pro Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys 
            580                 585                 590         


Ala Tyr Asn Pro Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser 
        595                 600                 605             


Gln Pro Gly Thr Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn 
    610                 615                 620                 


Ser Asp Ala Leu Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr 
625                 630                 635                 640 


Gln Ser Arg Glu Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser 
                645                 650                 655     


Gln Leu Thr Glu Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu 
            660                 665                 670         


Gln Ala Gln Thr Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser 
        675                 680                 685             


Pro Asn Ser Val Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala 
    690                 695                 700                 


Gly Ser Phe Thr Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp 
705                 710                 715                 720 


Leu Val Gln Gln Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu 
                725                 730                 735     


Phe Ser Ala Pro Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala 
            740                 745                 750         


Asp Ile Phe Gln Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly 
        755                 760                 765             


Met Phe Ser Ser Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu 
    770                 775                 780                 


Leu Pro Gly Arg Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu 
785                 790                 795                 800 


Ser Asn Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser 
                805                 810                 815     


Ser Ala Ala Met Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala 
            820                 825                 830         


Ala Gln Ile Gln Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly 
        835                 840                 845             


Asn Leu Gln Gln Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser 
    850                 855                 860                 


Ala Leu Ser Thr Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser 
865                 870                 875                 880 


Ser Pro Pro Ala Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln 
                885                 890                 895     


Gln Val Ala Thr Pro Gly Thr Thr Met Phe Gln Thr Ser Ser Ser Gly 
            900                 905                 910         


Asp Gly Glu Glu Thr Gly Thr Gln Ala Lys Gln Ile Gln Asn Ser Val 
        915                 920                 925             


Phe Gln Thr Met Val Gln Met Gln His Ser Gly Asp Asn Gln Pro Gln 
    930                 935                 940                 


Val Asn Leu Phe Ser Ser Thr Lys Ser Met Met Ser Val Gln Asn Ser 
945                 950                 955                 960 


Gly Thr Gln Gln Gln Gly Asn Gly Leu Phe Gln Gln Gly Asn Glu Met 
                965                 970                 975     


Met Ser Leu Gln Ser Gly Asn Phe Leu Gln Gln Ser Ser His Ser Gln 
            980                 985                 990         


Ala Gln Leu Phe His Pro Gln Asn  Pro Ile Ala Asp Ala  Gln Asn Leu 
        995                 1000                 1005             


Ser Gln  Glu Thr Gln Gly Ser  Leu Phe His Ser Pro  Asn Pro Ile 
    1010                 1015                 1020             


Val His  Ser Gln Thr Ser Thr  Thr Ser Ser Glu Gln  Met Gln Pro 
    1025                 1030                 1035             


Pro Met  Phe His Ser Gln Ser  Thr Ile Ala Val Leu  Gln Gly Ser 
    1040                 1045                 1050             


Ser Val  Pro Gln Asp Gln Gln  Ser Thr Asn Ile Phe  Leu Ser Gln 
    1055                 1060                 1065             


Ser Pro  Met Asn Asn Leu Gln  Thr Asn Thr Val Ala  Gln Glu Ala 
    1070                 1075                 1080             


Phe Phe  Ala Ala Pro Asn Ser  Ile Ser Pro Leu Gln  Ser Thr Ser 
    1085                 1090                 1095             


Asn Ser  Glu Gln Gln Ala Ala  Phe Gln Gln Gln Ala  Pro Ile Ser 
    1100                 1105                 1110             


His Ile  Gln Thr Pro Met Leu  Ser Gln Glu Gln Ala  Gln Pro Pro 
    1115                 1120                 1125             


Gln Gln  Gly Leu Phe Gln Pro  Gln Val Ala Leu Gly  Ser Leu Pro 
    1130                 1135                 1140             


Pro Asn  Pro Met Pro Gln Ser  Gln Gln Gly Thr Met  Phe Gln Ser 
    1145                 1150                 1155             


Gln His  Ser Ile Val Ala Met  Gln Ser Asn Ser Pro  Ser Gln Glu 
    1160                 1165                 1170             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1175                 1180                 1185             


Gln Gln  Ser Ile Leu Phe Ser  Asn Gln Asn Thr Met  Ala Thr Met 
    1190                 1195                 1200             


Ala Ser  Pro Lys Gln Pro Pro  Pro Asn Met Ile Phe  Asn Pro Asn 
    1205                 1210                 1215             


Gln Asn  Pro Met Ala Asn Gln  Glu Gln Gln Asn Gln  Ser Ile Phe 
    1220                 1225                 1230             


His Gln  Gln Ser Asn Met Ala  Pro Met Asn Gln Glu  Gln Gln Pro 
    1235                 1240                 1245             


Met Gln  Phe Gln Ser Gln Ser  Thr Val Ser Ser Leu  Gln Asn Pro 
    1250                 1255                 1260             


Gly Pro  Thr Gln Ser Glu Ser  Ser Gln Thr Pro Leu  Phe His Ser 
    1265                 1270                 1275             


Ser Pro  Gln Ile Gln Leu Val  Gln Gly Ser Pro Ser  Ser Gln Glu 
    1280                 1285                 1290             


Gln Gln  Val Thr Leu Phe Leu  Ser Pro Ala Ser Met  Ser Ala Leu 
    1295                 1300                 1305             


Gln Thr  Ser Ile Asn Gln Gln  Asp Met Gln Gln Ser  Pro Leu Tyr 
    1310                 1315                 1320             


Ser Pro  Gln Asn Asn Met Pro  Gly Ile Gln Gly Ala  Thr Ser Ser 
    1325                 1330                 1335             


Pro Gln  Pro Gln Ala Thr Leu  Phe His Asn Thr Ala  Gly Gly Thr 
    1340                 1345                 1350             


Met Asn  Gln Leu Gln Asn Ser  Pro Gly Ser Ser Gln  Gln Thr Ser 
    1355                 1360                 1365             


Gly Met  Phe Leu Phe Gly Ile  Gln Asn Asn Cys Ser  Gln Leu Leu 
    1370                 1375                 1380             


Thr Ser  Gly Pro Ala Thr Leu  Pro Asp Gln Leu Met  Ala Ile Ser 
    1385                 1390                 1395             


Gln Pro  Gly Gln Pro Gln Asn  Glu Gly Gln Pro Pro  Val Thr Thr 
    1400                 1405                 1410             


Leu Leu  Ser Gln Gln Met Pro  Glu Asn Ser Pro Leu  Ala Ser Ser 
    1415                 1420                 1425             


Ile Asn  Thr Asn Gln Asn Ile  Glu Lys Ile Asp Leu  Leu Val Ser 
    1430                 1435                 1440             


Leu Gln  Asn Gln Gly Asn Asn  Leu Thr Gly Ser Phe  
    1445                 1450                 1455 


<210>  507
<211>  1964
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (24)..(1601)

<400>  507
atagcaaggg atggtttaac aaa atg aag gca ctc att gca gca ctg ctt ttg       53
                          Met Lys Ala Leu Ile Ala Ala Leu Leu Leu         
                          1               5                   10          

atc aca ttg cag tat tcg tgt gcc gtg agt ccc act gac tgc agt gct        101
Ile Thr Leu Gln Tyr Ser Cys Ala Val Ser Pro Thr Asp Cys Ser Ala           
                15                  20                  25                

gtt gag ccg gag gct gag aaa gct cta gac ctg atc aat aaa agg cga        149
Val Glu Pro Glu Ala Glu Lys Ala Leu Asp Leu Ile Asn Lys Arg Arg           
            30                  35                  40                    

cgg gat ggc tac ctt ttc caa ttg ctg cgg att gct gat gcc cac ttg        197
Arg Asp Gly Tyr Leu Phe Gln Leu Leu Arg Ile Ala Asp Ala His Leu           
        45                  50                  55                        

gac aga gtg gaa aat aca act gta tat tac tta gtc tta gat gtg caa        245
Asp Arg Val Glu Asn Thr Thr Val Tyr Tyr Leu Val Leu Asp Val Gln           
    60                  65                  70                            

gaa tcg gac tgt tcg gtc cta tcc agg aaa tac tgg aat gac tgt gag        293
Glu Ser Asp Cys Ser Val Leu Ser Arg Lys Tyr Trp Asn Asp Cys Glu           
75                  80                  85                  90            

cca cct gat tcc aga cgt cca tct gaa ata gtg atc gga caa tgt aag        341
Pro Pro Asp Ser Arg Arg Pro Ser Glu Ile Val Ile Gly Gln Cys Lys           
                95                  100                 105               

gta ata gct aca aga cat tcc cat gaa tct cag gac ctc aga gtg att        389
Val Ile Ala Thr Arg His Ser His Glu Ser Gln Asp Leu Arg Val Ile           
            110                 115                 120                   

gac ttt aac tgc acc aca agt tct gtc tct tca gca ctg gcc aat acc        437
Asp Phe Asn Cys Thr Thr Ser Ser Val Ser Ser Ala Leu Ala Asn Thr           
        125                 130                 135                       

aaa gat agt ccg gtc ctc ata gat ttc ttt gag gat act gag cgc tac        485
Lys Asp Ser Pro Val Leu Ile Asp Phe Phe Glu Asp Thr Glu Arg Tyr           
    140                 145                 150                           

aga aaa caa gcc aac aaa gcc ctt gag aag tac aaa gag gag aat gat        533
Arg Lys Gln Ala Asn Lys Ala Leu Glu Lys Tyr Lys Glu Glu Asn Asp           
155                 160                 165                 170           

gac ttt gcc tct ttc aga gtg gac cga atc gag aga gtt gca aga gtg        581
Asp Phe Ala Ser Phe Arg Val Asp Arg Ile Glu Arg Val Ala Arg Val           
                175                 180                 185               

aga gga ggg gaa gga act ggt tac ttc gtg gac ttc tct gtg cgg aac        629
Arg Gly Gly Glu Gly Thr Gly Tyr Phe Val Asp Phe Ser Val Arg Asn           
            190                 195                 200                   

tgc ccc aga cac cat ttc ccc aga cac ccc aat gtc ttt gga ttc tgc        677
Cys Pro Arg His His Phe Pro Arg His Pro Asn Val Phe Gly Phe Cys           
        205                 210                 215                       

aga gca gat ttg ttc tat gat gta gaa gcc ttg gac ttg gaa agc ccg        725
Arg Ala Asp Leu Phe Tyr Asp Val Glu Ala Leu Asp Leu Glu Ser Pro           
    220                 225                 230                           

aaa aac ctt gtc ata aac tgt gaa gtc ttc gac cct cag gaa cat gag        773
Lys Asn Leu Val Ile Asn Cys Glu Val Phe Asp Pro Gln Glu His Glu           
235                 240                 245                 250           

aac atc aat ggt gta ccg cct cat ttg gga cat ccc ttc cac tgg ggt        821
Asn Ile Asn Gly Val Pro Pro His Leu Gly His Pro Phe His Trp Gly           
                255                 260                 265               

ggg cat gag cgt tct tct acc acc aag cct cca ttc aag ccc cat gga        869
Gly His Glu Arg Ser Ser Thr Thr Lys Pro Pro Phe Lys Pro His Gly           
            270                 275                 280                   

tct aga gat cat cat cat ccc cac aag cca cac gaa cat gga ccc cca        917
Ser Arg Asp His His His Pro His Lys Pro His Glu His Gly Pro Pro           
        285                 290                 295                       

cct cct cca gat gaa aga gat cac tca cat gga ccc cca ctt cca caa        965
Pro Pro Pro Asp Glu Arg Asp His Ser His Gly Pro Pro Leu Pro Gln           
    300                 305                 310                           

ggc cct cct cca cta ttg ccc atg tcc tgc tca agt tgt caa cat gcc       1013
Gly Pro Pro Pro Leu Leu Pro Met Ser Cys Ser Ser Cys Gln His Ala           
315                 320                 325                 330           

act ttt ggc aca aat ggg gcc caa aga cat tct cat aat aat aat tcc       1061
Thr Phe Gly Thr Asn Gly Ala Gln Arg His Ser His Asn Asn Asn Ser           
                335                 340                 345               

agt gac ctc cat ccc cat aag cat cat tcc cat gaa cag cat ccc cac       1109
Ser Asp Leu His Pro His Lys His His Ser His Glu Gln His Pro His           
            350                 355                 360                   

gga cac cat ccc cat gca cac cat cct cat gaa cat gat acc cat aga       1157
Gly His His Pro His Ala His His Pro His Glu His Asp Thr His Arg           
        365                 370                 375                       

cag cat ccc cat gga cac cac ccc cat gga cac cat cct cat gga cac       1205
Gln His Pro His Gly His His Pro His Gly His His Pro His Gly His           
    380                 385                 390                           

cac ccc cat gga cac cat ccc cat gga cac cat ccc cac tgc cat gat       1253
His Pro His Gly His His Pro His Gly His His Pro His Cys His Asp           
395                 400                 405                 410           

ttc caa gac tat gga cct tgt gac cca cca ccc cat aac caa ggt cac       1301
Phe Gln Asp Tyr Gly Pro Cys Asp Pro Pro Pro His Asn Gln Gly His           
                415                 420                 425               

tgt tgc cat ggc cac ggc cca cca cct ggg cac tta aga agg cga ggc       1349
Cys Cys His Gly His Gly Pro Pro Pro Gly His Leu Arg Arg Arg Gly           
            430                 435                 440                   

cca ggt aaa gga ccc cgt ccc ttc cat tgc aga caa att gga tct gtg       1397
Pro Gly Lys Gly Pro Arg Pro Phe His Cys Arg Gln Ile Gly Ser Val           
        445                 450                 455                       

tac cga ctc cct cct cta aga aaa ggt gag gtg ctg cca ctt cct gag       1445
Tyr Arg Leu Pro Pro Leu Arg Lys Gly Glu Val Leu Pro Leu Pro Glu           
    460                 465                 470                           

gcc aat ttt ccc agc ttc cca ttg ccg cac cac aaa cat cct cta aag       1493
Ala Asn Phe Pro Ser Phe Pro Leu Pro His His Lys His Pro Leu Lys           
475                 480                 485                 490           

cca gac aat cag ccc ttt cct caa tca gtc tct gaa tca tgt cca ggg       1541
Pro Asp Asn Gln Pro Phe Pro Gln Ser Val Ser Glu Ser Cys Pro Gly           
                495                 500                 505               

aag ttc aag agt ggg ttt cca caa gtt tcc atg ttt ttt aca cat aca       1589
Lys Phe Lys Ser Gly Phe Pro Gln Val Ser Met Phe Phe Thr His Thr           
            510                 515                 520                   

ttt cca aaa taa aatgtgattc ctttgaagag gaaaatgaat aatacattga           1641
Phe Pro Lys                                                               
        525                                                               

attagaaaca taaataaaat gaccagtaat tgtgaaaatt acagttcttt tcaacctact     1701

ttcatactga agatgcagca aaatgtgaat gggaaaagag atggcctgag aagagagatc     1761

aaatggaaag gagaggaaag aactcagtgc tgcctattag tagttaattc tgtcactcac     1821

cactacatca cttgagacaa atctatgcca ctcagaatct ccttctttcc tggacttaac     1881

tctaattcta gagtctctgt tactgcttgg gctatacctg ggcatactaa taaagtatgg     1941

tattgaaact aaaaaaaaaa aaa                                             1964


<210>  508
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  508

Met Lys Ala Leu Ile Ala Ala Leu Leu Leu Ile Thr Leu Gln Tyr Ser 
1               5                   10                  15      


Cys Ala Val Ser Pro Thr Asp Cys Ser Ala Val Glu Pro Glu Ala Glu 
            20                  25                  30          


Lys Ala Leu Asp Leu Ile Asn Lys Arg Arg Arg Asp Gly Tyr Leu Phe 
        35                  40                  45              


Gln Leu Leu Arg Ile Ala Asp Ala His Leu Asp Arg Val Glu Asn Thr 
    50                  55                  60                  


Thr Val Tyr Tyr Leu Val Leu Asp Val Gln Glu Ser Asp Cys Ser Val 
65                  70                  75                  80  


Leu Ser Arg Lys Tyr Trp Asn Asp Cys Glu Pro Pro Asp Ser Arg Arg 
                85                  90                  95      


Pro Ser Glu Ile Val Ile Gly Gln Cys Lys Val Ile Ala Thr Arg His 
            100                 105                 110         


Ser His Glu Ser Gln Asp Leu Arg Val Ile Asp Phe Asn Cys Thr Thr 
        115                 120                 125             


Ser Ser Val Ser Ser Ala Leu Ala Asn Thr Lys Asp Ser Pro Val Leu 
    130                 135                 140                 


Ile Asp Phe Phe Glu Asp Thr Glu Arg Tyr Arg Lys Gln Ala Asn Lys 
145                 150                 155                 160 


Ala Leu Glu Lys Tyr Lys Glu Glu Asn Asp Asp Phe Ala Ser Phe Arg 
                165                 170                 175     


Val Asp Arg Ile Glu Arg Val Ala Arg Val Arg Gly Gly Glu Gly Thr 
            180                 185                 190         


Gly Tyr Phe Val Asp Phe Ser Val Arg Asn Cys Pro Arg His His Phe 
        195                 200                 205             


Pro Arg His Pro Asn Val Phe Gly Phe Cys Arg Ala Asp Leu Phe Tyr 
    210                 215                 220                 


Asp Val Glu Ala Leu Asp Leu Glu Ser Pro Lys Asn Leu Val Ile Asn 
225                 230                 235                 240 


Cys Glu Val Phe Asp Pro Gln Glu His Glu Asn Ile Asn Gly Val Pro 
                245                 250                 255     


Pro His Leu Gly His Pro Phe His Trp Gly Gly His Glu Arg Ser Ser 
            260                 265                 270         


Thr Thr Lys Pro Pro Phe Lys Pro His Gly Ser Arg Asp His His His 
        275                 280                 285             


Pro His Lys Pro His Glu His Gly Pro Pro Pro Pro Pro Asp Glu Arg 
    290                 295                 300                 


Asp His Ser His Gly Pro Pro Leu Pro Gln Gly Pro Pro Pro Leu Leu 
305                 310                 315                 320 


Pro Met Ser Cys Ser Ser Cys Gln His Ala Thr Phe Gly Thr Asn Gly 
                325                 330                 335     


Ala Gln Arg His Ser His Asn Asn Asn Ser Ser Asp Leu His Pro His 
            340                 345                 350         


Lys His His Ser His Glu Gln His Pro His Gly His His Pro His Ala 
        355                 360                 365             


His His Pro His Glu His Asp Thr His Arg Gln His Pro His Gly His 
    370                 375                 380                 


His Pro His Gly His His Pro His Gly His His Pro His Gly His His 
385                 390                 395                 400 


Pro His Gly His His Pro His Cys His Asp Phe Gln Asp Tyr Gly Pro 
                405                 410                 415     


Cys Asp Pro Pro Pro His Asn Gln Gly His Cys Cys His Gly His Gly 
            420                 425                 430         


Pro Pro Pro Gly His Leu Arg Arg Arg Gly Pro Gly Lys Gly Pro Arg 
        435                 440                 445             


Pro Phe His Cys Arg Gln Ile Gly Ser Val Tyr Arg Leu Pro Pro Leu 
    450                 455                 460                 


Arg Lys Gly Glu Val Leu Pro Leu Pro Glu Ala Asn Phe Pro Ser Phe 
465                 470                 475                 480 


Pro Leu Pro His His Lys His Pro Leu Lys Pro Asp Asn Gln Pro Phe 
                485                 490                 495     


Pro Gln Ser Val Ser Glu Ser Cys Pro Gly Lys Phe Lys Ser Gly Phe 
            500                 505                 510         


Pro Gln Val Ser Met Phe Phe Thr His Thr Phe Pro Lys 
        515                 520                 525 


<210>  509
<211>  7042
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (396)..(6284)

<400>  509
caacgtgctg agctaatagc gacagataga gggcagacag attcctgcta gcagcttagt       60

gttagttgct tgtggtaact aaggcaggtg gcatacatct cagaacgtgg agaatgatgg      120

tatgctttct gagttaacat gttgaactgt tttgcttttc taaaaatttt cctagtaaca      180

ttttcttgat gatatgagag tggatatcaa tgcctcacag aaacaagagg tggaacatgt      240

gaatgaatcg tcttggaact agattatgag cactggttct ttttaaaggg atgtgcaaga      300

ggcagccttg gcaagaaaac ttgctgcata atcttacatg gactaaagat gaaactttaa      360

accgcaaatc agctttgagt gaactttgac agaag atg ttt cga cag ttt tat         413
                                       Met Phe Arg Gln Phe Tyr            
                                       1               5                  

ctc tgg aca tgt tta gct tca ggg atc atc ctg ggc tct ctc ttt gaa        461
Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile Leu Gly Ser Leu Phe Glu           
            10                  15                  20                    

atc tgc ttg ggc cag tat gat gat gac tgg caa tat gag gat tgc aaa        509
Ile Cys Leu Gly Gln Tyr Asp Asp Asp Trp Gln Tyr Glu Asp Cys Lys           
        25                  30                  35                        

cta gct agg gga gga cca cca gct acc ata gtt gct att gat gaa gaa        557
Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu Glu           
    40                  45                  50                            

agt cgg aat ggt aca att ctg gtg gac aac atg ctg atc aaa ggg act        605
Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly Thr           
55                  60                  65                  70            

gct gga gga cca gac ccc acc ata gaa ctt tct tta aag gat aat gtg        653
Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn Val           
                75                  80                  85                

gat tac tgg gtg ttg atg gat cct gtt aag caa atg ctt ttc ctg aac        701
Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu Asn           
            90                  95                  100                   

agc acc gga aga gtt ctg gat aga gat cca ccg atg aac ata cac tcc        749
Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His Ser           
        105                 110                 115                       

att gtg gtg cag gtc cag tgc atc aac aaa aaa gtg ggc act att atc        797
Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile Ile           
    120                 125                 130                           

tac cat gaa gtg cga ata gtg gtg aga gac agg aat gac aac tca ccc        845
Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser Pro           
135                 140                 145                 150           

act ttc aag cat gaa agc tac tat gcc aca gtg aat gag ctc act cca        893
Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr Pro           
                155                 160                 165               

gtt ggt acc aca ata ttc aca gga ttt tca gga gac aat gga gct aca        941
Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala Thr           
            170                 175                 180                   

gat ata gat gat gga cca aat gga cag ata gag tat gtt att cag tat        989
Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln Tyr           
        185                 190                 195                       

aat cca gat gat ccg aca tcc aat gac acc ttt gaa att ccc cta atg       1037
Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu Met           
    200                 205                 210                           

ttg act gga aat ata gtg tta agg aag agg ctc aac tat gaa gat aag       1085
Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp Lys           
215                 220                 225                 230           

act cgc tac ttt gtc ata atc caa gct aat gac cgt gcc caa aat ctg       1133
Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn Leu           
                235                 240                 245               

aat gag agg cga acc acc acc acc act ctc aca gtg gat gtt ctg gat       1181
Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu Asp           
            250                 255                 260                   

gga gat gac ttg ggt cca atg ttt ctt cct tgt gtc ctt gtg cca aac       1229
Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro Asn           
        265                 270                 275                       

act cgt gat tgc cgt cca ctc act tat caa gct gcc ata cct gag ttg       1277
Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu Leu           
    280                 285                 290                           

aga act ccg gaa gaa ctg aac ccc att att gtt acg cca cca atc caa       1325
Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile Gln           
295                 300                 305                 310           

gcc att gat cag gac cgg aat att caa ccg cca tca gat agg cca gga       1373
Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro Gly           
                315                 320                 325               

atc ctc tat tcc atc ctt gtt ggg act cct gag gat tac cca cga ttt       1421
Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg Phe           
            330                 335                 340                   

ttc cat atg cat cct agg aca gca gaa ctt agt ctc ctg gag cca gta       1469
Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro Val           
        345                 350                 355                       

aac aga gac ttt cac cag aaa ttt gat ttg gtt att aag gct gaa caa       1517
Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu Gln           
    360                 365                 370                           

gac aat ggt cat cct ctt cct gcc ttt gcc ggt cta cac att gaa ata       1565
Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu Ile           
375                 380                 385                 390           

ctg gat gaa aac aat caa agt cca tat ttt aca atg ccc agt tat caa       1613
Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr Gln           
                395                 400                 405               

ggc tat atc ctg gaa tct gcc cca gtg gga gca acc att tcg gac agt       1661
Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp Ser           
            410                 415                 420                   

ctc aat ttg act tca cct tta aga ata gta gct ctg gac aag gac ata       1709
Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp Ile           
        425                 430                 435                       

gaa gat aca aaa gac cca gag ctt cac ctt ttt ctg aat gac tac acc       1757
Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr Thr           
    440                 445                 450                           

tca gtc ttc acc gtc aca cag act ggt att act cgc tac ctc acc tta       1805
Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr Leu           
455                 460                 465                 470           

ctt caa cca gtg gac agg gaa gaa cag caa act tac acc ttt tcg ata       1853
Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser Ile           
                475                 480                 485               

aca gca ttt gat ggt gta caa gaa agt gag cca gtc atc gtc aat att       1901
Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn Ile           
            490                 495                 500                   

caa gtg atg gat gca aat gat aac acg cca acc ttc cct gaa ata tcc       1949
Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile Ser           
        505                 510                 515                       

tat gat gtg tat gtt tat aca gac atg aga cct ggg gac agt gtc ata       1997
Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val Ile           
    520                 525                 530                           

cag ctc act gca gtc gac gca gac gaa ggg tca aat ggg gag atc aca       2045
Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile Thr           
535                 540                 545                 550           

tat gaa atc ctt gtt ggg gct cag gga gac ttc atc atc aat aaa aca       2093
Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys Thr           
                555                 560                 565               

aca ggg ctt atc acc atc gct cca ggg gtg gaa atg ata gtc ggg cgg       2141
Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly Arg           
            570                 575                 580                   

act tac gca ctc acg gtc caa gca gcg gat aat gct cct cct gca gag       2189
Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala Glu           
        585                 590                 595                       

cga agg aac tcc atc tgc act gtg tat att gaa gtg ctt cca cca aat       2237
Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro Asn           
    600                 605                 610                           

aat caa agc cct cct cgc ttc cca cag ctg atg tat agc ctt gaa att       2285
Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu Ile           
615                 620                 625                 630           

agt gaa gcc atg agg gtt ggt gct gtt tta tta aat cta cag gca act       2333
Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala Thr           
                635                 640                 645               

gat cga gag gga gac tca ata aca tat gcc att gag aat gga gat cct       2381
Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp Pro           
            650                 655                 660                   

cag aga gtt ttt aat ctt tca gaa acc acg ggg att cta acc tta ggg       2429
Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu Gly           
        665                 670                 675                       

aaa gca ctg gac agg gaa agc act gat cgc tac att ctg atc atc aca       2477
Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile Thr           
    680                 685                 690                           

gct tca gat ggc agg cca gat ggg acc tca act gcc aca gta aac ata       2525
Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn Ile           
695                 700                 705                 710           

gtg gtg aca gat gtc aat gac aat gct cca gtg ttt gat cct tat ctg       2573
Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr Leu           
                715                 720                 725               

cca aga aat tta tct gtg gtg gaa gaa gaa gcc aat gcc ttt gtg ggt       2621
Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val Gly           
            730                 735                 740                   

caa gta aaa gca aca gac cct gat gct gga ata aat ggt caa gtg cac       2669
Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val His           
        745                 750                 755                       

tac agt ttg ggt aac ttt aat aat ctt ttt cgt atc aca tcc aat ggg       2717
Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn Gly           
    760                 765                 770                           

agc att tac aca gca gtg aag ctt aac aga gaa gtc agg gac tac tat       2765
Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr Tyr           
775                 780                 785                 790           

gaa ctt gtt gtt gtg gca aca gat gga gca gta cac cct cgt cat tca       2813
Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His Ser           
                795                 800                 805               

act cta acc ttg gcc atc aag gtt ttg gac att gat gat aac agt cct       2861
Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser Pro           
            810                 815                 820                   

gtg ttc acc aat tca aca tac act gtc ctt gtt gaa gag aat ttg cca       2909
Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu Pro           
        825                 830                 835                       

gct ggg act acc atc ctt caa ata gag gcc aaa gat gtc gac ctt gga       2957
Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu Gly           
    840                 845                 850                           

gca aat gtg tct tac cgg ata aga agc cca gaa gtg aag cac ttt ttt       3005
Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe Phe           
855                 860                 865                 870           

gca cta cat cca ttt aca gga gaa cta tcg ctt tta agg agt tta gat       3053
Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu Asp           
                875                 880                 885               

tat gag gca ttt cca gac caa gaa gca agt atc act ttt ctg gta gag       3101
Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val Glu           
            890                 895                 900                   

gcc ttt gat att tat gga aca atg cca cct ggt att gct act gtc aca       3149
Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val Thr           
        905                 910                 915                       

gtg att gta aag gat atg aat gat tat cct cct gtc ttt agt aaa cga       3197
Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys Arg           
    920                 925                 930                           

ata tac aaa ggg atg gtg gct ccg gat gca gtc aag ggt aca cct atc       3245
Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro Ile           
935                 940                 945                 950           

aca aca gtt tat gct gaa gat gca gac cct cct gga tta cct gca agt       3293
Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala Ser           
                955                 960                 965               

cgt gtg agg tat aga gta gat gat gta cag ttt cct tac cct gcc agt       3341
Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala Ser           
            970                 975                 980                   

att ttt gaa gtg gaa gaa gat tct gga aga gta ata aca cga gtc aat       3389
Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val Asn           
        985                 990                 995                       

ctt aat  gaa gaa cct aca aca  att ttt aag ttg gtg  gtg gtt gct        3434
Leu Asn  Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala            
    1000                 1005                 1010                        

ttt gat  gat ggg gag cct gtg  atg tcc agc agt gcc  aca gtg aag        3479
Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys            
    1015                 1020                 1025                        

att ctt  gtc tta cat cct ggt  gag atc cca cgc ttc  aca cag gag        3524
Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu            
    1030                 1035                 1040                        

gaa tat  aga cct cct cca gta  agt gaa ctt gcc acc  aaa ggg acc        3569
Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr            
    1045                 1050                 1055                        

atg gtt  ggt gta att tct gct  gct gcc att aat caa  agt att gtg        3614
Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val            
    1060                 1065                 1070                        

tac tcc  att gtt tca gga aat  gaa gaa gat aca ttt  gga att aat        3659
Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn            
    1075                 1080                 1085                        

aac atc  aca ggt gtt atc tat  gtg aat gga cct ctg  gat tat gag        3704
Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu            
    1090                 1095                 1100                        

acc agg  aca agc tat gta ctt  cga gtc caa gct gat  tcc ctg gaa        3749
Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu            
    1105                 1110                 1115                        

gtg gtc  ctt gcc aat ctc cga  gtt cct tca aaa agc  aat aca gct        3794
Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala            
    1120                 1125                 1130                        

aaa gta  tac att gag att cag  gat gaa aat aat cat  ccc cca gtg        3839
Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val            
    1135                 1140                 1145                        

ttt cag  aaa aaa ttc tac atc  gga ggt gta tct gaa  gat gca aga        3884
Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg            
    1150                 1155                 1160                        

atg ttt  act tct gta ctc aga  gtg aag gct act gat  aaa gat act        3929
Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr            
    1165                 1170                 1175                        

ggc aat  tat agt gtc atg gcc  tac aga ctc ata ata  cca cca att        3974
Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile            
    1180                 1185                 1190                        

aaa gag  gga aaa gaa gga ttt  gta gtg gaa aca tat  aca ggg ctt        4019
Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu            
    1195                 1200                 1205                        

atc aaa  act gct atg ctc ttc  cat aat atg agg aga  tcc tac ttc        4064
Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe            
    1210                 1215                 1220                        

aag ttt  caa gtt att gca act  gac gac tat ggg aag  gga ctg agc        4109
Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser            
    1225                 1230                 1235                        

ggc aaa  gcc gat gta ctc gtc  tcc gtg gtc aat cag  ctg gat atg        4154
Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met            
    1240                 1245                 1250                        

caa gtc  att gtt tcc aat gtg  cct cct act cta gtg  gaa aaa aag        4199
Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys            
    1255                 1260                 1265                        

ata gaa  gat ctt aca gag atc  ttg gat cgc tat gtt  cag gaa caa        4244
Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln            
    1270                 1275                 1280                        

att cct  ggt gcc aag gtc gta  gtg gag tcc att gga  gct cgc cgg        4289
Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg            
    1285                 1290                 1295                        

cat gga  gat gcc ttt tcc cta  gaa gat tac acc aaa  tgt gac ttg        4334
His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu            
    1300                 1305                 1310                        

act gtc  tat gca att gac ccc  caa acc aac aga gcc  atc gat aga        4379
Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg            
    1315                 1320                 1325                        

aat gag  ctt ttt aaa ttt ttg  gat ggc aaa cta ctt  gat atc aat        4424
Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn            
    1330                 1335                 1340                        

aaa gac  ttt cag ccg tat tat  ggg gaa gga gga cgc  att ctg gag        4469
Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu            
    1345                 1350                 1355                        

atc cgg  act cca gag gca gtg  acc agc att aaa aag  aga gga gaa        4514
Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu            
    1360                 1365                 1370                        

agt cta  gga tac aca gaa ggg  gcc ttg ttg gct ctg  gcc ttc atc        4559
Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile            
    1375                 1380                 1385                        

atc atc  ctc tgc tgc att cct  gcc atc ttg gtg gtt  ttg gtc agc        4604
Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser            
    1390                 1395                 1400                        

tac aga  cag ttt aaa gta cgt  caa gct gag tgt aca  aag act gca        4649
Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu Cys Thr  Lys Thr Ala            
    1405                 1410                 1415                        

cga att  cag gcc gca tta ccc  gcg gct aaa cca gca  gtg ccg gct        4694
Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys Pro Ala  Val Pro Ala            
    1420                 1425                 1430                        

cct gca  cca gtg gca gcg ccc  ccg ccg ccg ccg ccg  cct ccg cca        4739
Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro            
    1435                 1440                 1445                        

ggt gcg  cat ctc tat gaa gaa  ctt gga gac agc tca  atg cat aat        4784
Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp Ser Ser  Met His Asn            
    1450                 1455                 1460                        

ctt ttc  ctt ctc tac cat ttt  caa caa agc agg gga  aat aac tca        4829
Leu Phe  Leu Leu Tyr His Phe  Gln Gln Ser Arg Gly  Asn Asn Ser            
    1465                 1470                 1475                        

gtc tca  gaa gac agg aaa cat  caa caa gtt gtg atg  ccc ttt tct        4874
Val Ser  Glu Asp Arg Lys His  Gln Gln Val Val Met  Pro Phe Ser            
    1480                 1485                 1490                        

tcc aat  act att gag gct cac  aag tca gct cat gta  gac gga tca        4919
Ser Asn  Thr Ile Glu Ala His  Lys Ser Ala His Val  Asp Gly Ser            
    1495                 1500                 1505                        

ctt aag  agc aac aaa ctg aag  tct gca aga aaa ttc  aca ttt cta        4964
Leu Lys  Ser Asn Lys Leu Lys  Ser Ala Arg Lys Phe  Thr Phe Leu            
    1510                 1515                 1520                        

tct gat  gag gat gac tta agt  gcc cat aat ccc ctt  tat aag gaa        5009
Ser Asp  Glu Asp Asp Leu Ser  Ala His Asn Pro Leu  Tyr Lys Glu            
    1525                 1530                 1535                        

aac ata  agt caa gta tca aca  aat tca gac att tca  cag aga aca        5054
Asn Ile  Ser Gln Val Ser Thr  Asn Ser Asp Ile Ser  Gln Arg Thr            
    1540                 1545                 1550                        

gat ttt  gta gac cca ttt tca  ccc aaa ata caa gcc  aag agt aag        5099
Asp Phe  Val Asp Pro Phe Ser  Pro Lys Ile Gln Ala  Lys Ser Lys            
    1555                 1560                 1565                        

tct ctg  agg ggc cca aga gaa  aag att cag agg ctg  tgg agt cag        5144
Ser Leu  Arg Gly Pro Arg Glu  Lys Ile Gln Arg Leu  Trp Ser Gln            
    1570                 1575                 1580                        

tca gtc  agc tta ccc agg agg  ctg atg agg aaa gtt  cca aat aga        5189
Ser Val  Ser Leu Pro Arg Arg  Leu Met Arg Lys Val  Pro Asn Arg            
    1585                 1590                 1595                        

cca gag  atc ata gat ctg cag  cag tgg caa ggc acc  agg cag aaa        5234
Pro Glu  Ile Ile Asp Leu Gln  Gln Trp Gln Gly Thr  Arg Gln Lys            
    1600                 1605                 1610                        

gct gaa  aat gaa aac act gga  atc tgt aca aac aaa  aga ggt agc        5279
Ala Glu  Asn Glu Asn Thr Gly  Ile Cys Thr Asn Lys  Arg Gly Ser            
    1615                 1620                 1625                        

agc aat  cca ttg ctt aca act  gaa gag gca aat ttg  aca gag aaa        5324
Ser Asn  Pro Leu Leu Thr Thr  Glu Glu Ala Asn Leu  Thr Glu Lys            
    1630                 1635                 1640                        

gag gaa  ata agg caa ggt gaa  aca ctg atg ata gaa  gga aca gaa        5369
Glu Glu  Ile Arg Gln Gly Glu  Thr Leu Met Ile Glu  Gly Thr Glu            
    1645                 1650                 1655                        

cag ttg  aaa tct ctc tct tca  gac tct tca ttt tgc  ttt ccc agg        5414
Gln Leu  Lys Ser Leu Ser Ser  Asp Ser Ser Phe Cys  Phe Pro Arg            
    1660                 1665                 1670                        

cct cac  ttc tca ttc tcc act  ttg cca act gtt tca  aga act gtg        5459
Pro His  Phe Ser Phe Ser Thr  Leu Pro Thr Val Ser  Arg Thr Val            
    1675                 1680                 1685                        

gaa ctc  aaa tca gaa cct aat  gtc atc agt tct cct  gct gag tgt        5504
Glu Leu  Lys Ser Glu Pro Asn  Val Ile Ser Ser Pro  Ala Glu Cys            
    1690                 1695                 1700                        

tcc ttg  gaa ctt tct cct tca  agg cct tgt gtt tta  cat tct tca        5549
Ser Leu  Glu Leu Ser Pro Ser  Arg Pro Cys Val Leu  His Ser Ser            
    1705                 1710                 1715                        

ctc tct  agg aga gag aca cct  att tgt atg tta cct  att gaa acc        5594
Leu Ser  Arg Arg Glu Thr Pro  Ile Cys Met Leu Pro  Ile Glu Thr            
    1720                 1725                 1730                        

gaa aga  aat att ttt gaa aat  ttt gcc cat cca cca  aac atc tct        5639
Glu Arg  Asn Ile Phe Glu Asn  Phe Ala His Pro Pro  Asn Ile Ser            
    1735                 1740                 1745                        

cct tct  gcc tgt ccc ctt ccc  cct cct cct cct att  tct cct cct        5684
Pro Ser  Ala Cys Pro Leu Pro  Pro Pro Pro Pro Ile  Ser Pro Pro            
    1750                 1755                 1760                        

tct cct  cct cct gct cct gct  cct ctt gct cct cct  cct gac att        5729
Ser Pro  Pro Pro Ala Pro Ala  Pro Leu Ala Pro Pro  Pro Asp Ile            
    1765                 1770                 1775                        

tct cct  ttt tct ctt ttt tgt  cct cct ccc tct cct  cct tct atc        5774
Ser Pro  Phe Ser Leu Phe Cys  Pro Pro Pro Ser Pro  Pro Ser Ile            
    1780                 1785                 1790                        

cct ctt  cct ctt cct cct cct  aca ttt ttt cca ctt  tcc gtt tca        5819
Pro Leu  Pro Leu Pro Pro Pro  Thr Phe Phe Pro Leu  Ser Val Ser            
    1795                 1800                 1805                        

acg tct  ggt ccc cca aca cca  cct ctt cta cct cca  ttt cca act        5864
Thr Ser  Gly Pro Pro Thr Pro  Pro Leu Leu Pro Pro  Phe Pro Thr            
    1810                 1815                 1820                        

cct ctt  cct cca cca cct cct  tct att cct tgc cct  cca cct cct        5909
Pro Leu  Pro Pro Pro Pro Pro  Ser Ile Pro Cys Pro  Pro Pro Pro            
    1825                 1830                 1835                        

tca gct  tca ttt ctg tcc aca  gag tgt gtc tgt ata  aca ggt gtt        5954
Ser Ala  Ser Phe Leu Ser Thr  Glu Cys Val Cys Ile  Thr Gly Val            
    1840                 1845                 1850                        

aaa tgc  acg acc aac ttg atg  cct gcc gag aaa att  aag tcc tct        5999
Lys Cys  Thr Thr Asn Leu Met  Pro Ala Glu Lys Ile  Lys Ser Ser            
    1855                 1860                 1865                        

atg aca  cag cta tca aca acg  aca gtg tgt aaa aca  gac cct cag        6044
Met Thr  Gln Leu Ser Thr Thr  Thr Val Cys Lys Thr  Asp Pro Gln            
    1870                 1875                 1880                        

aga gaa  cca aaa ggc atc ctc  aga cac gtt aaa aac  tta gca gaa        6089
Arg Glu  Pro Lys Gly Ile Leu  Arg His Val Lys Asn  Leu Ala Glu            
    1885                 1890                 1895                        

ctt gaa  aaa tca gta gct aac  atg tac agt caa ata  gaa aaa aac        6134
Leu Glu  Lys Ser Val Ala Asn  Met Tyr Ser Gln Ile  Glu Lys Asn            
    1900                 1905                 1910                        

tat cta  cgc aca aat gtt tca  gaa ctt caa act atg  tgc cct tca        6179
Tyr Leu  Arg Thr Asn Val Ser  Glu Leu Gln Thr Met  Cys Pro Ser            
    1915                 1920                 1925                        

gaa gta  aca aat atg gaa atc  aca tct gaa caa aac  aag ggg agt        6224
Glu Val  Thr Asn Met Glu Ile  Thr Ser Glu Gln Asn  Lys Gly Ser            
    1930                 1935                 1940                        

ttg aac  aat att gtc gag gga  act gaa aaa caa tct  cac agt caa        6269
Leu Asn  Asn Ile Val Glu Gly  Thr Glu Lys Gln Ser  His Ser Gln            
    1945                 1950                 1955                        

tct act  tca ctg taa tgttgctttt cttattttag tcgggcaaac ctcttgttga      6324
Ser Thr  Ser Leu                                                          
    1960                                                                  

tcatagtctt caagttgaac atcaaatttg aacgtcaaag aagactctat tattttaccc     6384

caaattcaat gaaatgcagt tttttttctc gtttttaatt taaaaagata ttaacctcat     6444

cactactaac tcactcatat aatagattta ccttactttt taaaaactac aaagtagcat     6504

aatttgttct acatttattt gaaaagtaag taattttaat ctctttttta gtgggaatat     6564

gtgggcatga aaattagata cccaacttaa accaaaggca tgtctatcat gtggatgcag     6624

taacatttac atttagtttt tgatcgtagt tttatatgaa tgttccaaga aaaaagcaga     6684

ctgttacaaa taagttaaaa ctgatatgat tgataggttc tgttttttct tgaagcctat     6744

gtatttggta agaagaaata ctaccgaagt aaaatataat gtacctagat tgtaggagat     6804

gacagacata aggtatttca aaataaatct caggtgctat aacatgtagt catctgtttt     6864

ctgataagaa catcttttac tctgacttgc ttttatctta gtagtatgct tatggattta     6924

gtagtatgct tatggatttg ataaatctta tactttttca gttgctgtct tattctcttt     6984

atttctcatt gtgctttccc ttcccttctt tataatgaaa ataaatcttg agtcgttg       7042


<210>  510
<211>  1962
<212>  PRT
<213>  Homo sapiens

<400>  510

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Trp 
            20                  25                  30          


Gln Tyr Glu Asp Cys Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile 
        35                  40                  45              


Val Ala Ile Asp Glu Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn 
    50                  55                  60                  


Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu 
65                  70                  75                  80  


Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys 
                85                  90                  95      


Gln Met Leu Phe Leu Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro 
            100                 105                 110         


Pro Met Asn Ile His Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys 
        115                 120                 125             


Lys Val Gly Thr Ile Ile Tyr His Glu Val Arg Ile Val Val Arg Asp 
    130                 135                 140                 


Arg Asn Asp Asn Ser Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr 
145                 150                 155                 160 


Val Asn Glu Leu Thr Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser 
                165                 170                 175     


Gly Asp Asn Gly Ala Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile 
            180                 185                 190         


Glu Tyr Val Ile Gln Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr 
        195                 200                 205             


Phe Glu Ile Pro Leu Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg 
    210                 215                 220                 


Leu Asn Tyr Glu Asp Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn 
225                 230                 235                 240 


Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu 
                245                 250                 255     


Thr Val Asp Val Leu Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro 
            260                 265                 270         


Cys Val Leu Val Pro Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln 
        275                 280                 285             


Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile 
    290                 295                 300                 


Val Thr Pro Pro Ile Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro 
305                 310                 315                 320 


Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro 
                325                 330                 335     


Glu Asp Tyr Pro Arg Phe Phe His Met His Pro Arg Thr Ala Glu Leu 
            340                 345                 350         


Ser Leu Leu Glu Pro Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu 
        355                 360                 365             


Val Ile Lys Ala Glu Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala 
    370                 375                 380                 


Gly Leu His Ile Glu Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe 
385                 390                 395                 400 


Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly 
                405                 410                 415     


Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val 
            420                 425                 430         


Ala Leu Asp Lys Asp Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu 
        435                 440                 445             


Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile 
    450                 455                 460                 


Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln 
465                 470                 475                 480 


Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu 
                485                 490                 495     


Pro Val Ile Val Asn Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro 
            500                 505                 510         


Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg 
        515                 520                 525             


Pro Gly Asp Ser Val Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly 
    530                 535                 540                 


Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp 
545                 550                 555                 560 


Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val 
                565                 570                 575     


Glu Met Ile Val Gly Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp 
            580                 585                 590         


Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile 
        595                 600                 605             


Glu Val Leu Pro Pro Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu 
    610                 615                 620                 


Met Tyr Ser Leu Glu Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu 
625                 630                 635                 640 


Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala 
                645                 650                 655     


Ile Glu Asn Gly Asp Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr 
            660                 665                 670         


Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg 
        675                 680                 685             


Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser 
    690                 695                 700                 


Thr Ala Thr Val Asn Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro 
705                 710                 715                 720 


Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu 
                725                 730                 735     


Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly 
            740                 745                 750         


Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe 
        755                 760                 765             


Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg 
    770                 775                 780                 


Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala 
785                 790                 795                 800 


Val His Pro Arg His Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp 
                805                 810                 815     


Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu 
            820                 825                 830         


Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala 
        835                 840                 845             


Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro 
    850                 855                 860                 


Glu Val Lys His Phe Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser 
865                 870                 875                 880 


Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser 
                885                 890                 895     


Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro 
            900                 905                 910         


Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro 
        915                 920                 925             


Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala 
    930                 935                 940                 


Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro 
945                 950                 955                 960 


Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln 
                965                 970                 975     


Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg 
            980                 985                 990         


Val Ile Thr Arg Val Asn Leu Asn  Glu Glu Pro Thr Thr  Ile Phe Lys 
        995                 1000                 1005             


Leu Val  Val Val Ala Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser 
    1010                 1015                 1020             


Ser Ala  Thr Val Lys Ile Leu  Val Leu His Pro Gly  Glu Ile Pro 
    1025                 1030                 1035             


Arg Phe  Thr Gln Glu Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu 
    1040                 1045                 1050             


Ala Thr  Lys Gly Thr Met Val  Gly Val Ile Ser Ala  Ala Ala Ile 
    1055                 1060                 1065             


Asn Gln  Ser Ile Val Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp 
    1070                 1075                 1080             


Thr Phe  Gly Ile Asn Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly 
    1085                 1090                 1095             


Pro Leu  Asp Tyr Glu Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln 
    1100                 1105                 1110             


Ala Asp  Ser Leu Glu Val Val  Leu Ala Asn Leu Arg  Val Pro Ser 
    1115                 1120                 1125             


Lys Ser  Asn Thr Ala Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn 
    1130                 1135                 1140             


Asn His  Pro Pro Val Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val 
    1145                 1150                 1155             


Ser Glu  Asp Ala Arg Met Phe  Thr Ser Val Leu Arg  Val Lys Ala 
    1160                 1165                 1170             


Thr Asp  Lys Asp Thr Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu 
    1175                 1180                 1185             


Ile Ile  Pro Pro Ile Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu 
    1190                 1195                 1200             


Thr Tyr  Thr Gly Leu Ile Lys  Thr Ala Met Leu Phe  His Asn Met 
    1205                 1210                 1215             


Arg Arg  Ser Tyr Phe Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr 
    1220                 1225                 1230             


Gly Lys  Gly Leu Ser Gly Lys  Ala Asp Val Leu Val  Ser Val Val 
    1235                 1240                 1245             


Asn Gln  Leu Asp Met Gln Val  Ile Val Ser Asn Val  Pro Pro Thr 
    1250                 1255                 1260             


Leu Val  Glu Lys Lys Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg 
    1265                 1270                 1275             


Tyr Val  Gln Glu Gln Ile Pro  Gly Ala Lys Val Val  Val Glu Ser 
    1280                 1285                 1290             


Ile Gly  Ala Arg Arg His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr 
    1295                 1300                 1305             


Thr Lys  Cys Asp Leu Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn 
    1310                 1315                 1320             


Arg Ala  Ile Asp Arg Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys 
    1325                 1330                 1335             


Leu Leu  Asp Ile Asn Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly 
    1340                 1345                 1350             


Gly Arg  Ile Leu Glu Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile 
    1355                 1360                 1365             


Lys Lys  Arg Gly Glu Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu 
    1370                 1375                 1380             


Ala Leu  Ala Phe Ile Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu 
    1385                 1390                 1395             


Val Val  Leu Val Ser Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu 
    1400                 1405                 1410             


Cys Thr  Lys Thr Ala Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys 
    1415                 1420                 1425             


Pro Ala  Val Pro Ala Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro 
    1430                 1435                 1440             


Pro Pro  Pro Pro Pro Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp 
    1445                 1450                 1455             


Ser Ser  Met His Asn Leu Phe  Leu Leu Tyr His Phe  Gln Gln Ser 
    1460                 1465                 1470             


Arg Gly  Asn Asn Ser Val Ser  Glu Asp Arg Lys His  Gln Gln Val 
    1475                 1480                 1485             


Val Met  Pro Phe Ser Ser Asn  Thr Ile Glu Ala His  Lys Ser Ala 
    1490                 1495                 1500             


His Val  Asp Gly Ser Leu Lys  Ser Asn Lys Leu Lys  Ser Ala Arg 
    1505                 1510                 1515             


Lys Phe  Thr Phe Leu Ser Asp  Glu Asp Asp Leu Ser  Ala His Asn 
    1520                 1525                 1530             


Pro Leu  Tyr Lys Glu Asn Ile  Ser Gln Val Ser Thr  Asn Ser Asp 
    1535                 1540                 1545             


Ile Ser  Gln Arg Thr Asp Phe  Val Asp Pro Phe Ser  Pro Lys Ile 
    1550                 1555                 1560             


Gln Ala  Lys Ser Lys Ser Leu  Arg Gly Pro Arg Glu  Lys Ile Gln 
    1565                 1570                 1575             


Arg Leu  Trp Ser Gln Ser Val  Ser Leu Pro Arg Arg  Leu Met Arg 
    1580                 1585                 1590             


Lys Val  Pro Asn Arg Pro Glu  Ile Ile Asp Leu Gln  Gln Trp Gln 
    1595                 1600                 1605             


Gly Thr  Arg Gln Lys Ala Glu  Asn Glu Asn Thr Gly  Ile Cys Thr 
    1610                 1615                 1620             


Asn Lys  Arg Gly Ser Ser Asn  Pro Leu Leu Thr Thr  Glu Glu Ala 
    1625                 1630                 1635             


Asn Leu  Thr Glu Lys Glu Glu  Ile Arg Gln Gly Glu  Thr Leu Met 
    1640                 1645                 1650             


Ile Glu  Gly Thr Glu Gln Leu  Lys Ser Leu Ser Ser  Asp Ser Ser 
    1655                 1660                 1665             


Phe Cys  Phe Pro Arg Pro His  Phe Ser Phe Ser Thr  Leu Pro Thr 
    1670                 1675                 1680             


Val Ser  Arg Thr Val Glu Leu  Lys Ser Glu Pro Asn  Val Ile Ser 
    1685                 1690                 1695             


Ser Pro  Ala Glu Cys Ser Leu  Glu Leu Ser Pro Ser  Arg Pro Cys 
    1700                 1705                 1710             


Val Leu  His Ser Ser Leu Ser  Arg Arg Glu Thr Pro  Ile Cys Met 
    1715                 1720                 1725             


Leu Pro  Ile Glu Thr Glu Arg  Asn Ile Phe Glu Asn  Phe Ala His 
    1730                 1735                 1740             


Pro Pro  Asn Ile Ser Pro Ser  Ala Cys Pro Leu Pro  Pro Pro Pro 
    1745                 1750                 1755             


Pro Ile  Ser Pro Pro Ser Pro  Pro Pro Ala Pro Ala  Pro Leu Ala 
    1760                 1765                 1770             


Pro Pro  Pro Asp Ile Ser Pro  Phe Ser Leu Phe Cys  Pro Pro Pro 
    1775                 1780                 1785             


Ser Pro  Pro Ser Ile Pro Leu  Pro Leu Pro Pro Pro  Thr Phe Phe 
    1790                 1795                 1800             


Pro Leu  Ser Val Ser Thr Ser  Gly Pro Pro Thr Pro  Pro Leu Leu 
    1805                 1810                 1815             


Pro Pro  Phe Pro Thr Pro Leu  Pro Pro Pro Pro Pro  Ser Ile Pro 
    1820                 1825                 1830             


Cys Pro  Pro Pro Pro Ser Ala  Ser Phe Leu Ser Thr  Glu Cys Val 
    1835                 1840                 1845             


Cys Ile  Thr Gly Val Lys Cys  Thr Thr Asn Leu Met  Pro Ala Glu 
    1850                 1855                 1860             


Lys Ile  Lys Ser Ser Met Thr  Gln Leu Ser Thr Thr  Thr Val Cys 
    1865                 1870                 1875             


Lys Thr  Asp Pro Gln Arg Glu  Pro Lys Gly Ile Leu  Arg His Val 
    1880                 1885                 1890             


Lys Asn  Leu Ala Glu Leu Glu  Lys Ser Val Ala Asn  Met Tyr Ser 
    1895                 1900                 1905             


Gln Ile  Glu Lys Asn Tyr Leu  Arg Thr Asn Val Ser  Glu Leu Gln 
    1910                 1915                 1920             


Thr Met  Cys Pro Ser Glu Val  Thr Asn Met Glu Ile  Thr Ser Glu 
    1925                 1930                 1935             


Gln Asn  Lys Gly Ser Leu Asn  Asn Ile Val Glu Gly  Thr Glu Lys 
    1940                 1945                 1950             


Gln Ser  His Ser Gln Ser Thr  Ser Leu 
    1955                 1960         


<210>  511
<211>  487
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (37)..(429)

<400>  511
actcactttc tgacttaggc cacaggtcgt tttacc atg tct gga cgt ggc aag         54
                                        Met Ser Gly Arg Gly Lys           
                                        1               5                 

cag ggc ggc aag gct cgc gcc aag gcc aaa acc cgc tcc tct aga gct        102
Gln Gly Gly Lys Ala Arg Ala Lys Ala Lys Thr Arg Ser Ser Arg Ala           
            10                  15                  20                    

ggg ctc caa ttt cct gta gga cga gtg cac cgc ctg ctc cgc aag ggc        150
Gly Leu Gln Phe Pro Val Gly Arg Val His Arg Leu Leu Arg Lys Gly           
        25                  30                  35                        

aac tac gct gag cgg gtc ggg gcc ggc gcg ccg gtt tac ctg gcg gcg        198
Asn Tyr Ala Glu Arg Val Gly Ala Gly Ala Pro Val Tyr Leu Ala Ala           
    40                  45                  50                            

gtg ctg gag tac cta act gcc gag atc ctg gag ctg gcg ggc aac gca        246
Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu Glu Leu Ala Gly Asn Ala           
55                  60                  65                  70            

gcc cgc gac aac aaa aag acc cgc atc atc ccg cgc cac ttg cag ctg        294
Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile Pro Arg His Leu Gln Leu           
                75                  80                  85                

gcc atc cgc aac gac gag gag ctc aac aag ctg ctt ggt aaa gtt acc        342
Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys Leu Leu Gly Lys Val Thr           
            90                  95                  100                   

atc gct cag ggc ggt gtt ctg cct aac atc cag gcc gta ctg ctc ccc        390
Ile Ala Gln Gly Gly Val Leu Pro Asn Ile Gln Ala Val Leu Leu Pro           
        105                 110                 115                       

aag aag act gag agc cac cac aaa gct aag ggc aag taa gggctgaact         439
Lys Lys Thr Glu Ser His His Lys Ala Lys Gly Lys                           
    120                 125                 130                           

ttaaaaatgt aaacttacaa gacaaaaggc tcttttcaga gccaccca                   487


<210>  512
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  512

Met Ser Gly Arg Gly Lys Gln Gly Gly Lys Ala Arg Ala Lys Ala Lys 
1               5                   10                  15      


Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
            20                  25                  30          


Arg Leu Leu Arg Lys Gly Asn Tyr Ala Glu Arg Val Gly Ala Gly Ala 
        35                  40                  45              


Pro Val Tyr Leu Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu 
    50                  55                  60                  


Glu Leu Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile 
65                  70                  75                  80  


Pro Arg His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys 
                85                  90                  95      


Leu Leu Gly Lys Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Leu Leu Pro Lys Lys Thr Glu Ser His His Lys Ala Lys 
        115                 120                 125             


Gly Lys 
    130 


<210>  513
<211>  3341
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (149)..(1483)

<400>  513
cattgtctct cgctgacgcc agagatccag ctatcgtctt cactgctctg tgccgtcagc       60

tcctagaggc ccagcctctg tggccctgtg acctgcaggt attaggaggg tcacagctag      120

gacgccggga ccccctggaa gcctagaa atg gga cca ttg caa ttt aga gat         172
                               Met Gly Pro Leu Gln Phe Arg Asp            
                               1               5                          

gtg gcc ata gaa ttc tct ctg gag gag tgg cat tgc ctg gac gct gca        220
Val Ala Ile Glu Phe Ser Leu Glu Glu Trp His Cys Leu Asp Ala Ala           
    10                  15                  20                            

cag cgg aat cta tat agg gat gtg atg tta gag aac tac aga aac ctg        268
Gln Arg Asn Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu           
25                  30                  35                  40            

atc ttc ctt ggt att gtt gtc tct aaa cca aac ctg atc acc tgt ctg        316
Ile Phe Leu Gly Ile Val Val Ser Lys Pro Asn Leu Ile Thr Cys Leu           
                45                  50                  55                

gag caa gga aaa aaa cct tta act atg aag agg cat gag atg att gcc        364
Glu Gln Gly Lys Lys Pro Leu Thr Met Lys Arg His Glu Met Ile Ala           
            60                  65                  70                    

aaa ccc cca gtt atg tat tct cat ttt gcc caa gac ctt tgg tca gag        412
Lys Pro Pro Val Met Tyr Ser His Phe Ala Gln Asp Leu Trp Ser Glu           
        75                  80                  85                        

cag agc ata aaa gat tct ttc caa aaa gtg ata cta aga aga tat gaa        460
Gln Ser Ile Lys Asp Ser Phe Gln Lys Val Ile Leu Arg Arg Tyr Glu           
    90                  95                  100                           

aaa tgt aga cat gac aat tta cag tta aaa aaa ggc tgt gaa agt gta        508
Lys Cys Arg His Asp Asn Leu Gln Leu Lys Lys Gly Cys Glu Ser Val           
105                 110                 115                 120           

gat gag tgt cca gtg cac aaa aga ggt tat aat gga ctt aaa caa tgt        556
Asp Glu Cys Pro Val His Lys Arg Gly Tyr Asn Gly Leu Lys Gln Cys           
                125                 130                 135               

ttg gca act acc cag aga aaa ata ttt caa tgt gat gaa tat gtg aaa        604
Leu Ala Thr Thr Gln Arg Lys Ile Phe Gln Cys Asp Glu Tyr Val Lys           
            140                 145                 150                   

ttc ttg cat aaa ttt tca aat tca aac aaa cat aag ata aga gat act        652
Phe Leu His Lys Phe Ser Asn Ser Asn Lys His Lys Ile Arg Asp Thr           
        155                 160                 165                       

gga aaa aaa tct ttt aaa tgt ata gaa tat ggg aaa act ttt aac cag        700
Gly Lys Lys Ser Phe Lys Cys Ile Glu Tyr Gly Lys Thr Phe Asn Gln           
    170                 175                 180                           

tct tca acc cgt act aca tat aag aaa att gat gct gga gag aaa cgc        748
Ser Ser Thr Arg Thr Thr Tyr Lys Lys Ile Asp Ala Gly Glu Lys Arg           
185                 190                 195                 200           

tat aaa tgt gaa gaa tgt ggt aaa gcc tat aag cag tcc tca cac ctt        796
Tyr Lys Cys Glu Glu Cys Gly Lys Ala Tyr Lys Gln Ser Ser His Leu           
                205                 210                 215               

act aca cat aag aaa att cat act gga gag aaa ccc tac aaa tgt gaa        844
Thr Thr His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu           
            220                 225                 230                   

gaa tgt ggc aaa gcc tat aag cag tcc tgt aac ctt act aca cat aag        892
Glu Cys Gly Lys Ala Tyr Lys Gln Ser Cys Asn Leu Thr Thr His Lys           
        235                 240                 245                       

ata att cat act gga gag aaa ccc tac aga tgt aga gaa tgt ggc aaa        940
Ile Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Arg Glu Cys Gly Lys           
    250                 255                 260                           

gct ttt aac cac cct gca acc ctt ttt tca cat aag aaa att cat act        988
Ala Phe Asn His Pro Ala Thr Leu Phe Ser His Lys Lys Ile His Thr           
265                 270                 275                 280           

gga gag aaa cca tac aag tgt gat aaa tgt ggc aaa gcc ttt att tca       1036
Gly Glu Lys Pro Tyr Lys Cys Asp Lys Cys Gly Lys Ala Phe Ile Ser           
                285                 290                 295               

tcc tca acc ctt act aaa cat gag ata att cat act gga gag aaa ccc       1084
Ser Ser Thr Leu Thr Lys His Glu Ile Ile His Thr Gly Glu Lys Pro           
            300                 305                 310                   

tac aaa tgt gag gaa tgt ggc aaa gct ttt aac cgt tcc tca aac ctt       1132
Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser Ser Asn Leu           
        315                 320                 325                       

act aaa cat aag aga att cat act gga gat gta ccc tac aaa tgt gac       1180
Thr Lys His Lys Arg Ile His Thr Gly Asp Val Pro Tyr Lys Cys Asp           
    330                 335                 340                           

gaa tgt ggc aaa acc ttt acc tgg tac tca agc ctc tct aaa cat aag       1228
Glu Cys Gly Lys Thr Phe Thr Trp Tyr Ser Ser Leu Ser Lys His Lys           
345                 350                 355                 360           

aga gct cat act gga gag aaa ccc tac aag tgt gaa gaa tgt ggc aaa       1276
Arg Ala His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys           
                365                 370                 375               

gcc ttt act gca ttc tca act cta act gaa cat aag ata att cat act       1324
Ala Phe Thr Ala Phe Ser Thr Leu Thr Glu His Lys Ile Ile His Thr           
            380                 385                 390                   

gga gag aaa ccg tac aaa tgt gaa gaa tgt ggc aaa gct ttt aac tgg       1372
Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Trp           
        395                 400                 405                       

tcc tca gcc ctt aat aaa cat aag aaa att cat att aga cag aaa ccc       1420
Ser Ser Ala Leu Asn Lys His Lys Lys Ile His Ile Arg Gln Lys Pro           
    410                 415                 420                           

tgc ata gtg aag aat gtg gaa aat ctt tta aat gtt cct caa ccc tta       1468
Cys Ile Val Lys Asn Val Glu Asn Leu Leu Asn Val Pro Gln Pro Leu           
425                 430                 435                 440           

ata agc ata aga taa ttcatactgg agagaaaccg tatgaatgtg atgaatgtgg       1523
Ile Ser Ile Arg                                                           
                                                                          

gaaagccttt aactagccct ggactctgac taaatatgag aatttatatg gaacataaac     1583

cctacaaata taaagaatgt gacaaagctt tttaaggaag ttctcaaccc ttattacaca     1643

taatttatac tggacagaaa ccctacaagt gtgaagaata tggcaaagcc tataacaacc     1703

tgtcaactct ttttgttttt tgagatggag tttcactctt gtcacccagg ctggagtgca     1763

atggcacgat ctcagctcac tgcaacttct gcctcctggt atcaagccat tctcctgcct     1823

cagcctcccg agtagctggg attactggtg cccaccacca tgcccagcta atttttgtat     1883

ttttagtaga gatggggttt catcatgttt gccagactgg tctccaactc ctgacctcag     1943

atggtccacc cacctcggca tcctaaagtg ctgagatgac aggcatgagc cacgacgccc     2003

agccacaagt tctcaattct taagagacat ggcgataatt catgctgaag aggaactcta     2063

caaacctgaa agatgcaaca gtgcttttac caccacctcc aacttttgta tacataaaaa     2123

taaattatac taatgtgaaa ccctggaaat gtatgaaatg agacaaagcg tttatatggt     2183

tgccacactt gattgtaggt aagagaatta atgctgccaa aactcctaca agtgtgaaga     2243

atgtggcaaa acttttgagt gcttacacct tatttcacag gaaagctttt atccttgaga     2303

aaaatcgtac agatataaag aatatggaaa cgccattaac gcccactcac atctcaacag     2363

aaggttcata gttaataaaa gcaataaaag tgcaattact gtcaaaaaat ctttcagaaa     2423

atataagcct ttaaagaaga atatttattc tgaaatcagc tattacaaat ataagggggg     2483

gttgtagtac ctttacttgt atcacagatc ttgttgcaca cattgtgtac tagaggaaaa     2543

cctgaagcag ttgctccagc tttattcaac aacatggaat ttatattgga gaagagtcct     2603

gcaaatataa tgaatttgga aagacttttt ttttcaaaat ctatagctta gaaaacatca     2663

gagagtttat actaaagtat atttttgcag atgtaaatat gaaaaaaata tttaattcaa     2723

aattgatttt acgtaaatat gagaatttac actagaataa ggcactgaca cttcagacat     2783

tacactaaat cagagtattg agtataaaaa tgaatccaca actaaagctg tttttgtata     2843

taactttaaa agggagattt tctgaagcat tgtaatttca ttgaaagtgt acttgtttct     2903

tgaaaaaaat ttttgaacag tgaataatga tgtaatacaa ctttcaaatt tctttacgct     2963

gttattttat tcctattgtg gtcacatgtg aaagcatgtg atcaattgtt gctgcatcag     3023

ggatattaca gattcttttt tattgggtat tatgaccttt tctataaaag aataaggaca     3083

ttaaaatgta agatgcatga taaaaatgta agtggagagg ctctttgtag ttaacttata     3143

ttaagtaatg tataaggtgg gggttctcat ttgtataatc ctagcctatg acttaatgtt     3203

gatgttttgc tttgtctttt ggatggccta acctacatta acatgttggc agaccatttt     3263

aaaacttttt ttttcaaaaa ttataatgaa ttactttatt aataaagatt tttaaaaagt     3323

gaaaaaaaaa aaaaaaaa                                                   3341


<210>  514
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  514

Met Gly Pro Leu Gln Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp His Cys Leu Asp Ala Ala Gln Arg Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Ile Phe Leu Gly Ile Val Val Ser 
        35                  40                  45              


Lys Pro Asn Leu Ile Thr Cys Leu Glu Gln Gly Lys Lys Pro Leu Thr 
    50                  55                  60                  


Met Lys Arg His Glu Met Ile Ala Lys Pro Pro Val Met Tyr Ser His 
65                  70                  75                  80  


Phe Ala Gln Asp Leu Trp Ser Glu Gln Ser Ile Lys Asp Ser Phe Gln 
                85                  90                  95      


Lys Val Ile Leu Arg Arg Tyr Glu Lys Cys Arg His Asp Asn Leu Gln 
            100                 105                 110         


Leu Lys Lys Gly Cys Glu Ser Val Asp Glu Cys Pro Val His Lys Arg 
        115                 120                 125             


Gly Tyr Asn Gly Leu Lys Gln Cys Leu Ala Thr Thr Gln Arg Lys Ile 
    130                 135                 140                 


Phe Gln Cys Asp Glu Tyr Val Lys Phe Leu His Lys Phe Ser Asn Ser 
145                 150                 155                 160 


Asn Lys His Lys Ile Arg Asp Thr Gly Lys Lys Ser Phe Lys Cys Ile 
                165                 170                 175     


Glu Tyr Gly Lys Thr Phe Asn Gln Ser Ser Thr Arg Thr Thr Tyr Lys 
            180                 185                 190         


Lys Ile Asp Ala Gly Glu Lys Arg Tyr Lys Cys Glu Glu Cys Gly Lys 
        195                 200                 205             


Ala Tyr Lys Gln Ser Ser His Leu Thr Thr His Lys Lys Ile His Thr 
    210                 215                 220                 


Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Tyr Lys Gln 
225                 230                 235                 240 


Ser Cys Asn Leu Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro 
                245                 250                 255     


Tyr Arg Cys Arg Glu Cys Gly Lys Ala Phe Asn His Pro Ala Thr Leu 
            260                 265                 270         


Phe Ser His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp 
        275                 280                 285             


Lys Cys Gly Lys Ala Phe Ile Ser Ser Ser Thr Leu Thr Lys His Glu 
    290                 295                 300                 


Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys 
305                 310                 315                 320 


Ala Phe Asn Arg Ser Ser Asn Leu Thr Lys His Lys Arg Ile His Thr 
                325                 330                 335     


Gly Asp Val Pro Tyr Lys Cys Asp Glu Cys Gly Lys Thr Phe Thr Trp 
            340                 345                 350         


Tyr Ser Ser Leu Ser Lys His Lys Arg Ala His Thr Gly Glu Lys Pro 
        355                 360                 365             


Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Thr Ala Phe Ser Thr Leu 
    370                 375                 380                 


Thr Glu His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
385                 390                 395                 400 


Glu Cys Gly Lys Ala Phe Asn Trp Ser Ser Ala Leu Asn Lys His Lys 
                405                 410                 415     


Lys Ile His Ile Arg Gln Lys Pro Cys Ile Val Lys Asn Val Glu Asn 
            420                 425                 430         


Leu Leu Asn Val Pro Gln Pro Leu Ile Ser Ile Arg 
        435                 440                 


<210>  515
<211>  1725
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (58)..(1557)

<400>  515
ctacgggcac cgtggccaca cctgcctgca cagccagggc caggaggagg agatgcc          57

atg acc ctc att ctc aca agc ctg ctc ttc ttt ggg ctg agc ctg ggc        105
Met Thr Leu Ile Leu Thr Ser Leu Leu Phe Phe Gly Leu Ser Leu Gly           
1               5                   10                  15                

ccc agg acc cgg gtg cag gca gaa aac cta ccc aaa ccc atc ctg tgg        153
Pro Arg Thr Arg Val Gln Ala Glu Asn Leu Pro Lys Pro Ile Leu Trp           
            20                  25                  30                    

gcc gag cca ggt ccc gtg atc acc tgg cat aac ccc gtg acc atc tgg        201
Ala Glu Pro Gly Pro Val Ile Thr Trp His Asn Pro Val Thr Ile Trp           
        35                  40                  45                        

tgt cag ggc acc ctg gag gcc cag ggg tac cgt ctg gat aaa gag gga        249
Cys Gln Gly Thr Leu Glu Ala Gln Gly Tyr Arg Leu Asp Lys Glu Gly           
    50                  55                  60                            

aac tca atg tcg agg cac ata tta aaa aca ctg gag tct gaa aac aag        297
Asn Ser Met Ser Arg His Ile Leu Lys Thr Leu Glu Ser Glu Asn Lys           
65                  70                  75                  80            

gtc aaa ctc tcc atc cca tcc atg atg tgg gaa cat gca ggg cga tat        345
Val Lys Leu Ser Ile Pro Ser Met Met Trp Glu His Ala Gly Arg Tyr           
                85                  90                  95                

cac tgt tac tat cag agc cct gca ggc tgg tca gag ccc agc gac ccc        393
His Cys Tyr Tyr Gln Ser Pro Ala Gly Trp Ser Glu Pro Ser Asp Pro           
            100                 105                 110                   

ctg gag ctg gtg gtg aca gcc tac agc aga ccc acc ctg tcc gca ctg        441
Leu Glu Leu Val Val Thr Ala Tyr Ser Arg Pro Thr Leu Ser Ala Leu           
        115                 120                 125                       

cca agc cct gtg gtg acc tca gga gtg aac gtg acc ctc cgg tgt gcc        489
Pro Ser Pro Val Val Thr Ser Gly Val Asn Val Thr Leu Arg Cys Ala           
    130                 135                 140                           

tca cgg ctg gga ctg ggc agg ttc act ctg att gag gaa gga gac cac        537
Ser Arg Leu Gly Leu Gly Arg Phe Thr Leu Ile Glu Glu Gly Asp His           
145                 150                 155                 160           

agg ctc tcc tgg acc ctg aac tca cac caa cac aac cat gga aag ttc        585
Arg Leu Ser Trp Thr Leu Asn Ser His Gln His Asn His Gly Lys Phe           
                165                 170                 175               

cag gcc ctg ttc ccc atg ggc ccc ctg acc ttc agc aac agg ggt aca        633
Gln Ala Leu Phe Pro Met Gly Pro Leu Thr Phe Ser Asn Arg Gly Thr           
            180                 185                 190                   

ttc aga tgc tac ggc tat gaa aac aac acc cca tac gtg tgg tcg gaa        681
Phe Arg Cys Tyr Gly Tyr Glu Asn Asn Thr Pro Tyr Val Trp Ser Glu           
        195                 200                 205                       

ccc agt gac ccc ctg cag cta ctg gtg tca ggc gtg tct agg aag ccc        729
Pro Ser Asp Pro Leu Gln Leu Leu Val Ser Gly Val Ser Arg Lys Pro           
    210                 215                 220                           

tcc ctc ctg acc ctg cag ggc cct gtc gtg acc ccc gga gag aat ctg        777
Ser Leu Leu Thr Leu Gln Gly Pro Val Val Thr Pro Gly Glu Asn Leu           
225                 230                 235                 240           

acc ctc cag tgt ggc tct gat gtc ggc tac atc aga tac act ctg tac        825
Thr Leu Gln Cys Gly Ser Asp Val Gly Tyr Ile Arg Tyr Thr Leu Tyr           
                245                 250                 255               

aag gag ggg gcc gat ggc ctc ccc cag cgc cct ggc cgg cag ccc cag        873
Lys Glu Gly Ala Asp Gly Leu Pro Gln Arg Pro Gly Arg Gln Pro Gln           
            260                 265                 270                   

gct ggg ctc tcc cag gcc aac ttc acc ctg agc cct gtg agc cgc tcc        921
Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Ser Pro Val Ser Arg Ser           
        275                 280                 285                       

tac ggg ggc cag tac aga tgc tac ggc gca cac aac gtc tcc tcc gag        969
Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Val Ser Ser Glu           
    290                 295                 300                           

tgg tcg gcc ccc agt gac ccc ctg gac atc ctg atc gca gga cag atc       1017
Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly Gln Ile           
305                 310                 315                 320           

tct gac aga ccc tcc ctc tca gtg cag ccg ggc ccc acg gtg acc tca       1065
Ser Asp Arg Pro Ser Leu Ser Val Gln Pro Gly Pro Thr Val Thr Ser           
                325                 330                 335               

gga gag aag gtg acc ctg ctg tgt cag tca tgg gac ccg atg ttc act       1113
Gly Glu Lys Val Thr Leu Leu Cys Gln Ser Trp Asp Pro Met Phe Thr           
            340                 345                 350                   

ttc ctt ctg acc aag gag ggg gca gcc cat ccc ccg ttg cgt ctg aga       1161
Phe Leu Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Arg Leu Arg           
        355                 360                 365                       

tca atg tac gga gct cat aag tac cag gct gaa ttc ccc atg agt cct       1209
Ser Met Tyr Gly Ala His Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro           
    370                 375                 380                           

gtg acc tca gcc cac gcg ggg acc tac agg tgc tac ggc tca cgc agc       1257
Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Arg Ser           
385                 390                 395                 400           

tcc aac ccc tac ctg ctg tct cac ccc agt gag ccc ctg gag ctc gtg       1305
Ser Asn Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu Val           
                405                 410                 415               

gtc tca gga gca act gag acc ctc aat cca gca caa aag aag tca gat       1353
Val Ser Gly Ala Thr Glu Thr Leu Asn Pro Ala Gln Lys Lys Ser Asp           
            420                 425                 430                   

tcc aag act gcc cca cac ctc cag gat tac aca gtg gag aat ctc atc       1401
Ser Lys Thr Ala Pro His Leu Gln Asp Tyr Thr Val Glu Asn Leu Ile           
        435                 440                 445                       

cgc atg ggt gtg gct ggc ttg gtc ctg ctg ttc ctc ggg att ctg tta       1449
Arg Met Gly Val Ala Gly Leu Val Leu Leu Phe Leu Gly Ile Leu Leu           
    450                 455                 460                           

ttt gag gct cag cac agc cag aga agc ccc cca agg tgc agc cag gag       1497
Phe Glu Ala Gln His Ser Gln Arg Ser Pro Pro Arg Cys Ser Gln Glu           
465                 470                 475                 480           

gca aac agc aga aag gac aat gca ccc ttc aga gtg gtg gag cct tgg       1545
Ala Asn Ser Arg Lys Asp Asn Ala Pro Phe Arg Val Val Glu Pro Trp           
                485                 490                 495               

gaa cag atc tga tgatctgagg aggttctgga agactggggc agcagttggg           1597
Glu Gln Ile                                                               
                                                                          

gaagtgtctg ctgagaatat caaggggaag aagcatgggt caggtgcagg aagatgtctg     1657

ggtgtctgta gaagatgctt cctccattaa actgtggtgc tttcctcctc aaaaaaaaaa     1717

aaaaaaaa                                                              1725


<210>  516
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  516

Met Thr Leu Ile Leu Thr Ser Leu Leu Phe Phe Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Val Gln Ala Glu Asn Leu Pro Lys Pro Ile Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Pro Val Ile Thr Trp His Asn Pro Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Thr Leu Glu Ala Gln Gly Tyr Arg Leu Asp Lys Glu Gly 
    50                  55                  60                  


Asn Ser Met Ser Arg His Ile Leu Lys Thr Leu Glu Ser Glu Asn Lys 
65                  70                  75                  80  


Val Lys Leu Ser Ile Pro Ser Met Met Trp Glu His Ala Gly Arg Tyr 
                85                  90                  95      


His Cys Tyr Tyr Gln Ser Pro Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Val Thr Ala Tyr Ser Arg Pro Thr Leu Ser Ala Leu 
        115                 120                 125             


Pro Ser Pro Val Val Thr Ser Gly Val Asn Val Thr Leu Arg Cys Ala 
    130                 135                 140                 


Ser Arg Leu Gly Leu Gly Arg Phe Thr Leu Ile Glu Glu Gly Asp His 
145                 150                 155                 160 


Arg Leu Ser Trp Thr Leu Asn Ser His Gln His Asn His Gly Lys Phe 
                165                 170                 175     


Gln Ala Leu Phe Pro Met Gly Pro Leu Thr Phe Ser Asn Arg Gly Thr 
            180                 185                 190         


Phe Arg Cys Tyr Gly Tyr Glu Asn Asn Thr Pro Tyr Val Trp Ser Glu 
        195                 200                 205             


Pro Ser Asp Pro Leu Gln Leu Leu Val Ser Gly Val Ser Arg Lys Pro 
    210                 215                 220                 


Ser Leu Leu Thr Leu Gln Gly Pro Val Val Thr Pro Gly Glu Asn Leu 
225                 230                 235                 240 


Thr Leu Gln Cys Gly Ser Asp Val Gly Tyr Ile Arg Tyr Thr Leu Tyr 
                245                 250                 255     


Lys Glu Gly Ala Asp Gly Leu Pro Gln Arg Pro Gly Arg Gln Pro Gln 
            260                 265                 270         


Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Ser Pro Val Ser Arg Ser 
        275                 280                 285             


Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Val Ser Ser Glu 
    290                 295                 300                 


Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly Gln Ile 
305                 310                 315                 320 


Ser Asp Arg Pro Ser Leu Ser Val Gln Pro Gly Pro Thr Val Thr Ser 
                325                 330                 335     


Gly Glu Lys Val Thr Leu Leu Cys Gln Ser Trp Asp Pro Met Phe Thr 
            340                 345                 350         


Phe Leu Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Arg Leu Arg 
        355                 360                 365             


Ser Met Tyr Gly Ala His Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro 
    370                 375                 380                 


Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Arg Ser 
385                 390                 395                 400 


Ser Asn Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu Val 
                405                 410                 415     


Val Ser Gly Ala Thr Glu Thr Leu Asn Pro Ala Gln Lys Lys Ser Asp 
            420                 425                 430         


Ser Lys Thr Ala Pro His Leu Gln Asp Tyr Thr Val Glu Asn Leu Ile 
        435                 440                 445             


Arg Met Gly Val Ala Gly Leu Val Leu Leu Phe Leu Gly Ile Leu Leu 
    450                 455                 460                 


Phe Glu Ala Gln His Ser Gln Arg Ser Pro Pro Arg Cys Ser Gln Glu 
465                 470                 475                 480 


Ala Asn Ser Arg Lys Asp Asn Ala Pro Phe Arg Val Val Glu Pro Trp 
                485                 490                 495     


Glu Gln Ile 
            


<210>  517
<211>  1068
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (144)..(878)

<400>  517
ctcccaggga gggcagcgca agacagcaag tcatctccat ttcctggccc actttcaaaa       60

tggcagccgg aaggaaattt gtgattagaa gccgcgctgt tcttatttaa gagcgttagc      120

gcaacttccg gtattgttgc aag atg gcc gcg ccc agt gat gga ttc aag cct      173
                          Met Ala Ala Pro Ser Asp Gly Phe Lys Pro         
                          1               5                   10          

cgt gaa cga agc ggt ggg gag cag gca cag gac tgg gat gct ctg cca        221
Arg Glu Arg Ser Gly Gly Glu Gln Ala Gln Asp Trp Asp Ala Leu Pro           
                15                  20                  25                

ccc aag cgg ccc cga cta ggg gca gga aac aag atc gga ggc cgt agg        269
Pro Lys Arg Pro Arg Leu Gly Ala Gly Asn Lys Ile Gly Gly Arg Arg           
            30                  35                  40                    

ctt att gtg gtg ctg gaa ggg gcc agt ctg gag aca gtc aag gta ggg        317
Leu Ile Val Val Leu Glu Gly Ala Ser Leu Glu Thr Val Lys Val Gly           
        45                  50                  55                        

aag aca tat gag cta ctc aac tgt gac aag cac aag tct ata ttg ttg        365
Lys Thr Tyr Glu Leu Leu Asn Cys Asp Lys His Lys Ser Ile Leu Leu           
    60                  65                  70                            

aag aat gga cgg gac cct ggg gaa gcg cgg cca gat atc acc cac cag        413
Lys Asn Gly Arg Asp Pro Gly Glu Ala Arg Pro Asp Ile Thr His Gln           
75                  80                  85                  90            

agt ttg ctg atg ctg atg gat agt ccc ctg aac cga gct ggc ttg cta        461
Ser Leu Leu Met Leu Met Asp Ser Pro Leu Asn Arg Ala Gly Leu Leu           
                95                  100                 105               

cag gtt tat atc cat aca cag aag aat gtt ctg att gaa gtg aat ccc        509
Gln Val Tyr Ile His Thr Gln Lys Asn Val Leu Ile Glu Val Asn Pro           
            110                 115                 120                   

cag acc cga att ccc aga acc ttt gac cgc ttt tgt ggc ctc atg gtt        557
Gln Thr Arg Ile Pro Arg Thr Phe Asp Arg Phe Cys Gly Leu Met Val           
        125                 130                 135                       

caa ctt tta cac aag ctc agt gtt cga gca gct gat ggc ccc cag aag        605
Gln Leu Leu His Lys Leu Ser Val Arg Ala Ala Asp Gly Pro Gln Lys           
    140                 145                 150                           

ctt ttg aag gta att aag aat cca gta tca gat cac ttt cca gtt gga        653
Leu Leu Lys Val Ile Lys Asn Pro Val Ser Asp His Phe Pro Val Gly           
155                 160                 165                 170           

tgt atg aaa gtt ggc act tct ttt tcc atc ccg gtt gtc agt gat gtg        701
Cys Met Lys Val Gly Thr Ser Phe Ser Ile Pro Val Val Ser Asp Val           
                175                 180                 185               

cgt gag ctg gtg ccc agc agt gat cct att gtt ttt gtg gta ggg gcc        749
Arg Glu Leu Val Pro Ser Ser Asp Pro Ile Val Phe Val Val Gly Ala           
            190                 195                 200                   

ttt gcc cat ggc aag gtc agt gtg gag tat aca gag aag atg gtg tcc        797
Phe Ala His Gly Lys Val Ser Val Glu Tyr Thr Glu Lys Met Val Ser           
        205                 210                 215                       

atc agt aac tac ccc ctt tct gct gcc ctc acc tgt gca aaa ctt acc        845
Ile Ser Asn Tyr Pro Leu Ser Ala Ala Leu Thr Cys Ala Lys Leu Thr           
    220                 225                 230                           

aca gcc ttt gag gaa gta tgg ggg gtc att tga cagtagtaga acctgttctg      898
Thr Ala Phe Glu Glu Val Trp Gly Val Ile                                   
235                 240                                                   

aaaccagaaa ctgttgatgt cacatccttt gaccctggtc tgagctgact gctggaagat      958

gatctttctg cactgagact gtggagtttg gggaagccaa ggctgtacat ttgctatttg     1018

tttatcctat gaatactgtt cttgcaaacc tgaaaaaaaa aaaaaaaaaa                1068


<210>  518
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  518

Met Ala Ala Pro Ser Asp Gly Phe Lys Pro Arg Glu Arg Ser Gly Gly 
1               5                   10                  15      


Glu Gln Ala Gln Asp Trp Asp Ala Leu Pro Pro Lys Arg Pro Arg Leu 
            20                  25                  30          


Gly Ala Gly Asn Lys Ile Gly Gly Arg Arg Leu Ile Val Val Leu Glu 
        35                  40                  45              


Gly Ala Ser Leu Glu Thr Val Lys Val Gly Lys Thr Tyr Glu Leu Leu 
    50                  55                  60                  


Asn Cys Asp Lys His Lys Ser Ile Leu Leu Lys Asn Gly Arg Asp Pro 
65                  70                  75                  80  


Gly Glu Ala Arg Pro Asp Ile Thr His Gln Ser Leu Leu Met Leu Met 
                85                  90                  95      


Asp Ser Pro Leu Asn Arg Ala Gly Leu Leu Gln Val Tyr Ile His Thr 
            100                 105                 110         


Gln Lys Asn Val Leu Ile Glu Val Asn Pro Gln Thr Arg Ile Pro Arg 
        115                 120                 125             


Thr Phe Asp Arg Phe Cys Gly Leu Met Val Gln Leu Leu His Lys Leu 
    130                 135                 140                 


Ser Val Arg Ala Ala Asp Gly Pro Gln Lys Leu Leu Lys Val Ile Lys 
145                 150                 155                 160 


Asn Pro Val Ser Asp His Phe Pro Val Gly Cys Met Lys Val Gly Thr 
                165                 170                 175     


Ser Phe Ser Ile Pro Val Val Ser Asp Val Arg Glu Leu Val Pro Ser 
            180                 185                 190         


Ser Asp Pro Ile Val Phe Val Val Gly Ala Phe Ala His Gly Lys Val 
        195                 200                 205             


Ser Val Glu Tyr Thr Glu Lys Met Val Ser Ile Ser Asn Tyr Pro Leu 
    210                 215                 220                 


Ser Ala Ala Leu Thr Cys Ala Lys Leu Thr Thr Ala Phe Glu Glu Val 
225                 230                 235                 240 


Trp Gly Val Ile 
                


<210>  519
<211>  1327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (277)..(699)

<400>  519
ggtcgacgac gtggcagccg ggatgcacta ggcaaagcca gctgggctcc tgagtccggt       60

gggtacttgg agaacttact acgtctagct ggaggattgt aaatgtacca atcagcatgc      120

tgtgtctagc tcaagaactc aagctccatg aggagatgtt tcattgtcga gagcagtcat      180

gatggcctgc actccacaca atgcaacaga gtgaaagagc aggttctgct tctttggtgt      240

agtcctgaag cttcctaaga aacttcacat caggtg atg gat agg agc aac cct        294
                                        Met Asp Arg Ser Asn Pro           
                                        1               5                 

gta aaa cca gcc tta gac tat ttt tta aac agg ctg gtg aat tac cag        342
Val Lys Pro Ala Leu Asp Tyr Phe Leu Asn Arg Leu Val Asn Tyr Gln           
            10                  15                  20                    

atc tcc gtc aag tgc agt aac cag ttc aag ttg gaa gtg tgt ctt ttg        390
Ile Ser Val Lys Cys Ser Asn Gln Phe Lys Leu Glu Val Cys Leu Leu           
        25                  30                  35                        

aat gca gaa aac aaa gtc gtg gac aac cag gct ggg acc cag ggc cag        438
Asn Ala Glu Asn Lys Val Val Asp Asn Gln Ala Gly Thr Gln Gly Gln           
    40                  45                  50                            

ctg aag gtg ctg ggt gcc aac ctc tgg tgg ccg tac ctg atg cac gaa        486
Leu Lys Val Leu Gly Ala Asn Leu Trp Trp Pro Tyr Leu Met His Glu           
55                  60                  65                  70            

cac ccc gcc tac ctc tac tcg tgg gag gat ggt gat tgc tca cac caa        534
His Pro Ala Tyr Leu Tyr Ser Trp Glu Asp Gly Asp Cys Ser His Gln           
                75                  80                  85                

agc ctt gga ccc ctc cca gcc tgt gac ctt tgt gac caa ctc cac cta        582
Ser Leu Gly Pro Leu Pro Ala Cys Asp Leu Cys Asp Gln Leu His Leu           
            90                  95                  100                   

cgc agc aga caa ggg ggc tct gta tgt gga tgt gat ccg tgt gaa cag        630
Arg Ser Arg Gln Gly Gly Ser Val Cys Gly Cys Asp Pro Cys Glu Gln           
        105                 110                 115                       

cta cta ctc ttg gta tcg caa cta cgg gca cct gga gtt gat tca gct        678
Leu Leu Leu Leu Val Ser Gln Leu Arg Ala Pro Gly Val Asp Ser Ala           
    120                 125                 130                           

gca gct ggc cgc cca gtt tga gaattggtgt aagacatcac aatcccatta           729
Ala Ala Gly Arg Pro Val                                                   
135                 140                                                   

ttcagagcgc gtatggagtg gaaacgcttg tagggtttca ccagtctttc ccagggaact      789

ccgatgaagt gttccaacaa aatgagcgag tgaaccaaga agaggatgac attagatcca      849

ggagatacaa cagaggagat aatctccagg atgcctgtga agaaagatcc ctggatccca      909

ggatgattat aggacaagtt gttcataatc cagcaggcca gaagacttcc agggaaactc      969

attcaaggag gtgaaaatga tggatgactc ctccaagatg aaaatggacc agccgcagtg     1029

ctcacgcctg taataccagc actttgggag gctgaggcag gcggatcact tgaggtcagg     1089

agtttgaaac tagcctggcc aacgtggcaa aactccatct ctattaaaaa tacaaaaatt     1149

agccaggcat agtggtgcat gcctgtagtc ccagctactt gggatgccga ggcaggaaga     1209

attgcttgaa cctgggaggc agagtctgca gtgagccgag atcatgccac tgcactccag     1269

cctgggtgac agagccactc cgtctcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa       1327


<210>  520
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  520

Met Asp Arg Ser Asn Pro Val Lys Pro Ala Leu Asp Tyr Phe Leu Asn 
1               5                   10                  15      


Arg Leu Val Asn Tyr Gln Ile Ser Val Lys Cys Ser Asn Gln Phe Lys 
            20                  25                  30          


Leu Glu Val Cys Leu Leu Asn Ala Glu Asn Lys Val Val Asp Asn Gln 
        35                  40                  45              


Ala Gly Thr Gln Gly Gln Leu Lys Val Leu Gly Ala Asn Leu Trp Trp 
    50                  55                  60                  


Pro Tyr Leu Met His Glu His Pro Ala Tyr Leu Tyr Ser Trp Glu Asp 
65                  70                  75                  80  


Gly Asp Cys Ser His Gln Ser Leu Gly Pro Leu Pro Ala Cys Asp Leu 
                85                  90                  95      


Cys Asp Gln Leu His Leu Arg Ser Arg Gln Gly Gly Ser Val Cys Gly 
            100                 105                 110         


Cys Asp Pro Cys Glu Gln Leu Leu Leu Leu Val Ser Gln Leu Arg Ala 
        115                 120                 125             


Pro Gly Val Asp Ser Ala Ala Ala Gly Arg Pro Val 
    130                 135                 140 


<210>  521
<211>  3350
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (325)..(1698)

<400>  521
tagtcgcggg gcaggtacgt gcgctcgcgg ttctctcgcg gaggtcggcg gtggcgggag       60

cgggctccgg agagcctgag agcacggtgg ggcggggcgg gagaaagtgg ccgcccggag      120

gacgttggcg tttacgtgtg gaagagcgga agagttttgc ttttcgtgcg cgccttcgaa      180

aactgcctgc cgctgtctga ggagtccacc cgaaacctcc cctcctccgc cggcagcccc      240

gcgctgagct cgccgaccca agccagcgtg ggcgaggtgg gaagtgcgcc cgacccgcgc      300

ctggagctgc gcccccgagt gccc atg gct aca agg gtg ctg agc atg agc         351
                           Met Ala Thr Arg Val Leu Ser Met Ser            
                           1               5                              

gcc cgc ctg gga ccc gtg ccc cag ccg ccg gcg ccg cag gac gag ccg        399
Ala Arg Leu Gly Pro Val Pro Gln Pro Pro Ala Pro Gln Asp Glu Pro           
10                  15                  20                  25            

gtg ttc gcg cag ctc aag ccg gtg ctg ggc gcc gcg aat ccg gcc cgc        447
Val Phe Ala Gln Leu Lys Pro Val Leu Gly Ala Ala Asn Pro Ala Arg           
                30                  35                  40                

gac gcg gcg ctc ttc ccc ggc gag gag ctg aag cac gcg cac cac cgc        495
Asp Ala Ala Leu Phe Pro Gly Glu Glu Leu Lys His Ala His His Arg           
            45                  50                  55                    

ccg cag gcg cag ccc gcg ccc gcg cag gcc ccg cag ccg gcc cag ccg        543
Pro Gln Ala Gln Pro Ala Pro Ala Gln Ala Pro Gln Pro Ala Gln Pro           
        60                  65                  70                        

ccc gcc acc ggc ccg cgg ctg cct cca gag gac ctg gtc cag aca aga        591
Pro Ala Thr Gly Pro Arg Leu Pro Pro Glu Asp Leu Val Gln Thr Arg           
    75                  80                  85                            

tgt gaa atg gag aag tat ctg aca cct cag ctt cct cca gtt cct ata        639
Cys Glu Met Glu Lys Tyr Leu Thr Pro Gln Leu Pro Pro Val Pro Ile           
90                  95                  100                 105           

att cca gag cat aaa aag tat aga cga gac agt gcc tca gtc gta gac        687
Ile Pro Glu His Lys Lys Tyr Arg Arg Asp Ser Ala Ser Val Val Asp           
                110                 115                 120               

cag ttc ttc act gac act gaa ggg tta cct tac agt atc aac atg aac        735
Gln Phe Phe Thr Asp Thr Glu Gly Leu Pro Tyr Ser Ile Asn Met Asn           
            125                 130                 135                   

gtc ttc ctc cct gac atc act cac ctg aga act ggc ctc tac aaa tcc        783
Val Phe Leu Pro Asp Ile Thr His Leu Arg Thr Gly Leu Tyr Lys Ser           
        140                 145                 150                       

cag aga ccg tgc gta aca cac atc aag aca gaa cct gtt gcc att ttc        831
Gln Arg Pro Cys Val Thr His Ile Lys Thr Glu Pro Val Ala Ile Phe           
    155                 160                 165                           

agc cac cag agt gaa acg act gcc cct cct ccg gcc ccg acc cag gcc        879
Ser His Gln Ser Glu Thr Thr Ala Pro Pro Pro Ala Pro Thr Gln Ala           
170                 175                 180                 185           

ctc cct gag ttc acc agt ata ttc agc tca cac cag acc gca gct cca        927
Leu Pro Glu Phe Thr Ser Ile Phe Ser Ser His Gln Thr Ala Ala Pro           
                190                 195                 200               

gag gtg aac aat att ttc atc aaa caa gaa ctt cct aca cca gat ctt        975
Glu Val Asn Asn Ile Phe Ile Lys Gln Glu Leu Pro Thr Pro Asp Leu           
            205                 210                 215                   

cat ctt tct gtc cct acc cag cag ggc cac ctg tac cag cta ctg aat       1023
His Leu Ser Val Pro Thr Gln Gln Gly His Leu Tyr Gln Leu Leu Asn           
        220                 225                 230                       

aca ccg gat cta gat atg ccc agt tct aca aat cag aca gca gca atg       1071
Thr Pro Asp Leu Asp Met Pro Ser Ser Thr Asn Gln Thr Ala Ala Met           
    235                 240                 245                           

gac act ctt aat gtt tct atg tca gct gcc atg gca ggc ctt aac aca       1119
Asp Thr Leu Asn Val Ser Met Ser Ala Ala Met Ala Gly Leu Asn Thr           
250                 255                 260                 265           

cac acc tct gct gtt ccg cag act gca gtg aaa caa ttc cag ggc atg       1167
His Thr Ser Ala Val Pro Gln Thr Ala Val Lys Gln Phe Gln Gly Met           
                270                 275                 280               

ccc cct tgc aca tac aca atg cca agt cag ttt ctt cca caa cag gcc       1215
Pro Pro Cys Thr Tyr Thr Met Pro Ser Gln Phe Leu Pro Gln Gln Ala           
            285                 290                 295                   

act tac ttt ccc ccg tca cca cca agc tca gag cct gga agt cca gat       1263
Thr Tyr Phe Pro Pro Ser Pro Pro Ser Ser Glu Pro Gly Ser Pro Asp           
        300                 305                 310                       

aga caa gca gag atg ctc cag aat tta acc cca cct cca tcc tat gct       1311
Arg Gln Ala Glu Met Leu Gln Asn Leu Thr Pro Pro Pro Ser Tyr Ala           
    315                 320                 325                           

gct aca att gct tct aaa ctg gca att cac aat cca aat tta ccc acc       1359
Ala Thr Ile Ala Ser Lys Leu Ala Ile His Asn Pro Asn Leu Pro Thr           
330                 335                 340                 345           

acc ctg cca gtt aac tca caa aac atc caa cct gtc aga tac aat aga       1407
Thr Leu Pro Val Asn Ser Gln Asn Ile Gln Pro Val Arg Tyr Asn Arg           
                350                 355                 360               

agg agt aac ccc gat ttg gag aaa cga cgc atc cac tac tgc gat tac       1455
Arg Ser Asn Pro Asp Leu Glu Lys Arg Arg Ile His Tyr Cys Asp Tyr           
            365                 370                 375                   

cct ggt tgc aca aaa gtt tat acc aag tct tct cat tta aaa gct cac       1503
Pro Gly Cys Thr Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala His           
        380                 385                 390                       

ctg agg act cac act ggt gaa aag cca tac aag tgt acc tgg gaa ggc       1551
Leu Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Thr Trp Glu Gly           
    395                 400                 405                           

tgc gac tgg agg ttc gcg cga tcg gat gag ctg acc cgc cac tac cgg       1599
Cys Asp Trp Arg Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg           
410                 415                 420                 425           

aag cac aca ggc gcc aag ccc ttc cag tgc ggg gtg tgc aac cgc agc       1647
Lys His Thr Gly Ala Lys Pro Phe Gln Cys Gly Val Cys Asn Arg Ser           
                430                 435                 440               

ttc tcg cgc tct gac cac ctg gcc ctg cat atg aag agg cac cag aac       1695
Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Gln Asn           
            445                 450                 455                   

tga gcactgcccg tgtgacccgt tccaggtccc ctgggctccc tcaaatgaca            1748

gacctaacta ttcctgtgta aaaacaacaa aaacaaacaa aagcaagaaa accacaacta     1808

aaactggaaa tgtatatttt gtatatttga gaaaacaggg aatacattgt attaatacca     1868

aagtgtttgg tcattttaag aatctggaat gcttgctgta atgtatatgg ctttactcaa     1928

gcagatctca tctcatgaca ggcagccacg tctcaacatg ggtaaggggt gggggtggag     1988

gggagtgtgt gcagcgtttt tacctaggca ccatcattta atgtgacagt gttcagtaaa     2048

caaatcagtt ggcaggcacc agaagaagaa tggattgtat gtcaagattt tacttggcat     2108

tgagtagttt ttttcaatag taggtaattc cttagagata cagtatacct ggcaattcac     2168

aaatagccat tgaacaaatg tgtgggtttt taaaaattat atacatatat gagttgccta     2228

tatttgctat tcaaaatttt gtaaatatgc aaatcagctt tataggttta ttacaagttt     2288

tttaggattc ttttggggaa gagtcataat tcttttgaaa ataaccatga atacacttac     2348

agttaggatt tgtggtaagg tacctctcaa cattaccaaa atcatttctt tagagggaag     2408

gaataatcat tcaaatgaac tttaaaaaag caaatttcat gcactgatta aaataggatt     2468

attttaaata caaaaggcat tttatatgaa ttataaactg aagagcttaa agatagttac     2528

aaaatacaaa agttcaacct cttacaataa gctaaacgca atgtcatttt taaaaagaag     2588

gacttagggt gtcgttttca catatgacaa tgttgcattt atgatgcagt ttcaagtacc     2648

aaaacgttga attgatgatg cagttttcat atatcgagat gttcgctcgt gcagtactgt     2708

tggttaaatg acaatttatg tggattttgc atgtaataca cagtgagaca cagtaatttt     2768

atctaaatta cagtgcagtt tagttaatct attaatactg actcagtgtc tgcctttaaa     2828

tataaatgat atgttgaaaa cttaaggaag caaatgctac atatatgcaa tataaaatag     2888

taatgtgatg ctgatgctgt taaccaaagg gcagaataaa taagcaaaat gccaaaaggg     2948

gtcttaattg aaatgaaaat ttaattttgt ttttaaaata ttgtttatct ttatttattt     3008

tgtggtaata tagtaagttt ttttagaaga caattttcat aacttgataa attatagttt     3068

tgtttgttag aaaagttgct cttaaaagat gtaaatagat gacaaacgat gtaaataatt     3128

ttgtaagagg cttcaaaatg tttatacgtg gaaacacacc tacatgaaaa gcagaaatcg     3188

gttgctgttt tgcttctttt tccctcttat ttttgtattg tggtcatttc ctatgcaaat     3248

aatggagcaa acagctgtat agttgtagaa ttttttgaga gaatgagatg tttatatatt     3308

aacgacaatt ttttttttgg aaaataaaaa gtgcctaaaa ga                        3350


<210>  522
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  522

Met Ala Thr Arg Val Leu Ser Met Ser Ala Arg Leu Gly Pro Val Pro 
1               5                   10                  15      


Gln Pro Pro Ala Pro Gln Asp Glu Pro Val Phe Ala Gln Leu Lys Pro 
            20                  25                  30          


Val Leu Gly Ala Ala Asn Pro Ala Arg Asp Ala Ala Leu Phe Pro Gly 
        35                  40                  45              


Glu Glu Leu Lys His Ala His His Arg Pro Gln Ala Gln Pro Ala Pro 
    50                  55                  60                  


Ala Gln Ala Pro Gln Pro Ala Gln Pro Pro Ala Thr Gly Pro Arg Leu 
65                  70                  75                  80  


Pro Pro Glu Asp Leu Val Gln Thr Arg Cys Glu Met Glu Lys Tyr Leu 
                85                  90                  95      


Thr Pro Gln Leu Pro Pro Val Pro Ile Ile Pro Glu His Lys Lys Tyr 
            100                 105                 110         


Arg Arg Asp Ser Ala Ser Val Val Asp Gln Phe Phe Thr Asp Thr Glu 
        115                 120                 125             


Gly Leu Pro Tyr Ser Ile Asn Met Asn Val Phe Leu Pro Asp Ile Thr 
    130                 135                 140                 


His Leu Arg Thr Gly Leu Tyr Lys Ser Gln Arg Pro Cys Val Thr His 
145                 150                 155                 160 


Ile Lys Thr Glu Pro Val Ala Ile Phe Ser His Gln Ser Glu Thr Thr 
                165                 170                 175     


Ala Pro Pro Pro Ala Pro Thr Gln Ala Leu Pro Glu Phe Thr Ser Ile 
            180                 185                 190         


Phe Ser Ser His Gln Thr Ala Ala Pro Glu Val Asn Asn Ile Phe Ile 
        195                 200                 205             


Lys Gln Glu Leu Pro Thr Pro Asp Leu His Leu Ser Val Pro Thr Gln 
    210                 215                 220                 


Gln Gly His Leu Tyr Gln Leu Leu Asn Thr Pro Asp Leu Asp Met Pro 
225                 230                 235                 240 


Ser Ser Thr Asn Gln Thr Ala Ala Met Asp Thr Leu Asn Val Ser Met 
                245                 250                 255     


Ser Ala Ala Met Ala Gly Leu Asn Thr His Thr Ser Ala Val Pro Gln 
            260                 265                 270         


Thr Ala Val Lys Gln Phe Gln Gly Met Pro Pro Cys Thr Tyr Thr Met 
        275                 280                 285             


Pro Ser Gln Phe Leu Pro Gln Gln Ala Thr Tyr Phe Pro Pro Ser Pro 
    290                 295                 300                 


Pro Ser Ser Glu Pro Gly Ser Pro Asp Arg Gln Ala Glu Met Leu Gln 
305                 310                 315                 320 


Asn Leu Thr Pro Pro Pro Ser Tyr Ala Ala Thr Ile Ala Ser Lys Leu 
                325                 330                 335     


Ala Ile His Asn Pro Asn Leu Pro Thr Thr Leu Pro Val Asn Ser Gln 
            340                 345                 350         


Asn Ile Gln Pro Val Arg Tyr Asn Arg Arg Ser Asn Pro Asp Leu Glu 
        355                 360                 365             


Lys Arg Arg Ile His Tyr Cys Asp Tyr Pro Gly Cys Thr Lys Val Tyr 
    370                 375                 380                 


Thr Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr Gly Glu 
385                 390                 395                 400 


Lys Pro Tyr Lys Cys Thr Trp Glu Gly Cys Asp Trp Arg Phe Ala Arg 
                405                 410                 415     


Ser Asp Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly Ala Lys Pro 
            420                 425                 430         


Phe Gln Cys Gly Val Cys Asn Arg Ser Phe Ser Arg Ser Asp His Leu 
        435                 440                 445             


Ala Leu His Met Lys Arg His Gln Asn 
    450                 455         


<210>  523
<211>  1681
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (45)..(1106)

<400>  523
ggaggaagtt ataaagaggg tacgaggggg ccagctggag agcc atg cag tcc aag        56
                                                 Met Gln Ser Lys          
                                                 1                        

cgg gat tgt gag ctg tgg tgt gag agg gtg aat cca gag aac aag gcg        104
Arg Asp Cys Glu Leu Trp Cys Glu Arg Val Asn Pro Glu Asn Lys Ala           
5                   10                  15                  20            

gcg ctg gag gcg tgg gtc agg gag aca ggc atc cgc ctg gtg cag gtg        152
Ala Leu Glu Ala Trp Val Arg Glu Thr Gly Ile Arg Leu Val Gln Val           
                25                  30                  35                

aac ggg cag agg aag tat ggc ggg cca ccc cca ggc tgg gtg ggc agc        200
Asn Gly Gln Arg Lys Tyr Gly Gly Pro Pro Pro Gly Trp Val Gly Ser           
            40                  45                  50                    

ccg ccg cca gct ggg tca gag gtg ttc atc ggg cgg ctg cct cag gac        248
Pro Pro Pro Ala Gly Ser Glu Val Phe Ile Gly Arg Leu Pro Gln Asp           
        55                  60                  65                        

gtg tac gag cac cag ctt atc ccg ctg ttc cag cgc gtg ggc cgc ctc        296
Val Tyr Glu His Gln Leu Ile Pro Leu Phe Gln Arg Val Gly Arg Leu           
    70                  75                  80                            

tac gag ttc cgc ctg atg atg acc ttc agc ggc ctg aac cgc ggc ttc        344
Tyr Glu Phe Arg Leu Met Met Thr Phe Ser Gly Leu Asn Arg Gly Phe           
85                  90                  95                  100           

gcc tat gcc cgc tac agc tcg agg cgc ggc gcg cag gcc gcc atc gcc        392
Ala Tyr Ala Arg Tyr Ser Ser Arg Arg Gly Ala Gln Ala Ala Ile Ala           
                105                 110                 115               

acg ctg cac aac cat ccg ctg cgg ccg tcc tgc ccg ctg ctc gtg tgc        440
Thr Leu His Asn His Pro Leu Arg Pro Ser Cys Pro Leu Leu Val Cys           
            120                 125                 130                   

cgc agc acc gag aag tgt gag ctg agc gtt gac ggc ctg ccg ccg aat        488
Arg Ser Thr Glu Lys Cys Glu Leu Ser Val Asp Gly Leu Pro Pro Asn           
        135                 140                 145                       

ctg acc cgc agc gcg ctg ctg ctc gcg ctg cag ccg ctg ggt ccc ggc        536
Leu Thr Arg Ser Ala Leu Leu Leu Ala Leu Gln Pro Leu Gly Pro Gly           
    150                 155                 160                           

ttg cag gag gcg cgg ctg ctg ccc agc ccc gga ccg gcg ccc ggg cag        584
Leu Gln Glu Ala Arg Leu Leu Pro Ser Pro Gly Pro Ala Pro Gly Gln           
165                 170                 175                 180           

atc gct ctg ctc aaa ttc agc tcg cac cgg gcc gct gcc atg gcc aaa        632
Ile Ala Leu Leu Lys Phe Ser Ser His Arg Ala Ala Ala Met Ala Lys           
                185                 190                 195               

aag gcc ctg gtg gaa ggg cag tca cac ctc tgt gga gag cag gtg gct        680
Lys Ala Leu Val Glu Gly Gln Ser His Leu Cys Gly Glu Gln Val Ala           
            200                 205                 210                   

gtg gag tgg ctc aag cca gac ctg aag cag cga ctt cgc cag cag ctt        728
Val Glu Trp Leu Lys Pro Asp Leu Lys Gln Arg Leu Arg Gln Gln Leu           
        215                 220                 225                       

gtg ggt ccc ttc ttg cgg tcc cca cag cca gag ggc agc cag ttg gct        776
Val Gly Pro Phe Leu Arg Ser Pro Gln Pro Glu Gly Ser Gln Leu Ala           
    230                 235                 240                           

ttg gca agg gac aag tta ggg ttc caa ggg gct cgg gct acc ctg cag        824
Leu Ala Arg Asp Lys Leu Gly Phe Gln Gly Ala Arg Ala Thr Leu Gln           
245                 250                 255                 260           

ttg ctg tgc caa cga atg aag ctg ggc agc cct gtg ttc ctc acc aag        872
Leu Leu Cys Gln Arg Met Lys Leu Gly Ser Pro Val Phe Leu Thr Lys           
                265                 270                 275               

tgt ttg ggc ata gga cct gct ggc tgg cac cgc ttc tgg tac cag gtg        920
Cys Leu Gly Ile Gly Pro Ala Gly Trp His Arg Phe Trp Tyr Gln Val           
            280                 285                 290                   

gtg att cct ggg cat ccg gtg ccc ttc agc ggc ctc atc tgg gtt gtg        968
Val Ile Pro Gly His Pro Val Pro Phe Ser Gly Leu Ile Trp Val Val           
        295                 300                 305                       

ctg acc cta gat ggc cgg gat ggg cat gag gtg gcc aag gat gct gtg       1016
Leu Thr Leu Asp Gly Arg Asp Gly His Glu Val Ala Lys Asp Ala Val           
    310                 315                 320                           

tct gta cgg ctg ctg cag gca ctc agt gag tct ggg gcc aac ctc ctg       1064
Ser Val Arg Leu Leu Gln Ala Leu Ser Glu Ser Gly Ala Asn Leu Leu           
325                 330                 335                 340           

tgg tct gct ggg gct gag gca ggt acc atg gtt aaa cag tga               1106
Trp Ser Ala Gly Ala Glu Ala Gly Thr Met Val Lys Gln                       
                345                 350                                   

ctccattctt tctccacagg caccctgaat gggcatgcag agcctgtgtc aggccccatc     1166

ccagcaggcc tgggtggcca ctttctgacc cccaaaggtg gggaggggca tgggcccagg     1226

cccatcagcc tccctgctgg gacagggacc tatggcacct gggggcagct tgggtttggg     1286

ttaagttgtg gtgaggggcc ttgccctccc gctcccagcc cagggtccaa cctgacccag     1346

tgatcttcca tggccgttcc ttgtcccacc cccacccgat cataccttcc cccctctgcc     1406

acagcttagc atgaatcttc tttattgtcc tgatttgtcc tctttgttgg tttttatttg     1466

tggggaaggg cagctgagcc aaaggggtca gaaattctgc cctttgcctc caccacatgg     1526

cattctggtt ttggtttctg tatagttttg ggtctttcta tgctggttgt atttatatta     1586

aacccctggt tagtataaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1646

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                1681


<210>  524
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  524

Met Gln Ser Lys Arg Asp Cys Glu Leu Trp Cys Glu Arg Val Asn Pro 
1               5                   10                  15      


Glu Asn Lys Ala Ala Leu Glu Ala Trp Val Arg Glu Thr Gly Ile Arg 
            20                  25                  30          


Leu Val Gln Val Asn Gly Gln Arg Lys Tyr Gly Gly Pro Pro Pro Gly 
        35                  40                  45              


Trp Val Gly Ser Pro Pro Pro Ala Gly Ser Glu Val Phe Ile Gly Arg 
    50                  55                  60                  


Leu Pro Gln Asp Val Tyr Glu His Gln Leu Ile Pro Leu Phe Gln Arg 
65                  70                  75                  80  


Val Gly Arg Leu Tyr Glu Phe Arg Leu Met Met Thr Phe Ser Gly Leu 
                85                  90                  95      


Asn Arg Gly Phe Ala Tyr Ala Arg Tyr Ser Ser Arg Arg Gly Ala Gln 
            100                 105                 110         


Ala Ala Ile Ala Thr Leu His Asn His Pro Leu Arg Pro Ser Cys Pro 
        115                 120                 125             


Leu Leu Val Cys Arg Ser Thr Glu Lys Cys Glu Leu Ser Val Asp Gly 
    130                 135                 140                 


Leu Pro Pro Asn Leu Thr Arg Ser Ala Leu Leu Leu Ala Leu Gln Pro 
145                 150                 155                 160 


Leu Gly Pro Gly Leu Gln Glu Ala Arg Leu Leu Pro Ser Pro Gly Pro 
                165                 170                 175     


Ala Pro Gly Gln Ile Ala Leu Leu Lys Phe Ser Ser His Arg Ala Ala 
            180                 185                 190         


Ala Met Ala Lys Lys Ala Leu Val Glu Gly Gln Ser His Leu Cys Gly 
        195                 200                 205             


Glu Gln Val Ala Val Glu Trp Leu Lys Pro Asp Leu Lys Gln Arg Leu 
    210                 215                 220                 


Arg Gln Gln Leu Val Gly Pro Phe Leu Arg Ser Pro Gln Pro Glu Gly 
225                 230                 235                 240 


Ser Gln Leu Ala Leu Ala Arg Asp Lys Leu Gly Phe Gln Gly Ala Arg 
                245                 250                 255     


Ala Thr Leu Gln Leu Leu Cys Gln Arg Met Lys Leu Gly Ser Pro Val 
            260                 265                 270         


Phe Leu Thr Lys Cys Leu Gly Ile Gly Pro Ala Gly Trp His Arg Phe 
        275                 280                 285             


Trp Tyr Gln Val Val Ile Pro Gly His Pro Val Pro Phe Ser Gly Leu 
    290                 295                 300                 


Ile Trp Val Val Leu Thr Leu Asp Gly Arg Asp Gly His Glu Val Ala 
305                 310                 315                 320 


Lys Asp Ala Val Ser Val Arg Leu Leu Gln Ala Leu Ser Glu Ser Gly 
                325                 330                 335     


Ala Asn Leu Leu Trp Ser Ala Gly Ala Glu Ala Gly Thr Met Val Lys 
            340                 345                 350         


Gln 
    


<210>  525
<211>  1604
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (58)..(1485)

<400>  525
cctccgcccg cccgcctgcc tgcctgcccg cccgctcgct cgcccggccc gcgactc          57

atg tcc cgc cgc aag gcc ggc agc gcg ccc cgc cga gta gag ccc gcg        105
Met Ser Arg Arg Lys Ala Gly Ser Ala Pro Arg Arg Val Glu Pro Ala           
1               5                   10                  15                

ccc gcc gcc aac cca gac gac gag atg gaa atg cag gac ctc gtc atc        153
Pro Ala Ala Asn Pro Asp Asp Glu Met Glu Met Gln Asp Leu Val Ile           
            20                  25                  30                    

gaa ctc aag ccc gag cca gac gcg cag ccc caa cag gcc cca agg ctg        201
Glu Leu Lys Pro Glu Pro Asp Ala Gln Pro Gln Gln Ala Pro Arg Leu           
        35                  40                  45                        

ggg ccc ttc tcc ccg aag gag gtg tcc tcg gcg ggg cgg ttc ggc ggc        249
Gly Pro Phe Ser Pro Lys Glu Val Ser Ser Ala Gly Arg Phe Gly Gly           
    50                  55                  60                            

gaa ccc cac cac tcc cct ggc ccc atg ccc gcc ggg gcc gcc ctc ctc        297
Glu Pro His His Ser Pro Gly Pro Met Pro Ala Gly Ala Ala Leu Leu           
65                  70                  75                  80            

gcc ctc ggc ccg cgg aac ccg tgg acc ctg tgg acg ccg ttg acc ccg        345
Ala Leu Gly Pro Arg Asn Pro Trp Thr Leu Trp Thr Pro Leu Thr Pro           
                85                  90                  95                

aac tat ccc gac cgc cag ccc tgg acc gac aaa cac cca gat ctg ttg        393
Asn Tyr Pro Asp Arg Gln Pro Trp Thr Asp Lys His Pro Asp Leu Leu           
            100                 105                 110                   

acc tgc ggc cgc tgc ctg cag acc ttc ccg ttg gag gcc atc act gcc        441
Thr Cys Gly Arg Cys Leu Gln Thr Phe Pro Leu Glu Ala Ile Thr Ala           
        115                 120                 125                       

ttc atg gac cac aag aag ctg ggc tgt cag ctc ttc aga ggc ccc agc        489
Phe Met Asp His Lys Lys Leu Gly Cys Gln Leu Phe Arg Gly Pro Ser           
    130                 135                 140                           

cgc ggc cag ggc tca gaa cga gag gag ctg aag gcc ttg agc tgc ctg        537
Arg Gly Gln Gly Ser Glu Arg Glu Glu Leu Lys Ala Leu Ser Cys Leu           
145                 150                 155                 160           

cgc tgt ggc aaa cag ttc aca gtg gcc tgg aag ctg ctg cgt cac gcc        585
Arg Cys Gly Lys Gln Phe Thr Val Ala Trp Lys Leu Leu Arg His Ala           
                165                 170                 175               

cag tgg gac cac gga ctg tcc atc tac cag aca gaa tca gag gcc ccg        633
Gln Trp Asp His Gly Leu Ser Ile Tyr Gln Thr Glu Ser Glu Ala Pro           
            180                 185                 190                   

gag gcc ccg ctc ctg ggc ctg gcc gag gtg gct gca gcc gtg tcg gca        681
Glu Ala Pro Leu Leu Gly Leu Ala Glu Val Ala Ala Ala Val Ser Ala           
        195                 200                 205                       

gtg gtg ggg cca gca gct gag gcc aag agc ccc cgt gca agt ggc agc        729
Val Val Gly Pro Ala Ala Glu Ala Lys Ser Pro Arg Ala Ser Gly Ser           
    210                 215                 220                           

ggc ctc acc cgg cgg agc ccc acc tgt cct gtg tgc aag aag acc ctc        777
Gly Leu Thr Arg Arg Ser Pro Thr Cys Pro Val Cys Lys Lys Thr Leu           
225                 230                 235                 240           

agc tcc ttc agc aac ctc aaa gtg cac atg cgc tca cac aca ggc gag        825
Ser Ser Phe Ser Asn Leu Lys Val His Met Arg Ser His Thr Gly Glu           
                245                 250                 255               

cgg ccc tat gct tgc gac cag tgt ccc tac gcc tgc gcc cag agc agc        873
Arg Pro Tyr Ala Cys Asp Gln Cys Pro Tyr Ala Cys Ala Gln Ser Ser           
            260                 265                 270                   

aag ctc aac cgc cac aag aag acc cac cgg cag gtg ccg ccc cag agc        921
Lys Leu Asn Arg His Lys Lys Thr His Arg Gln Val Pro Pro Gln Ser           
        275                 280                 285                       

ccc ctc atg gcc gac acc agc cag gag cag gcc tct gca gcc cct ccg        969
Pro Leu Met Ala Asp Thr Ser Gln Glu Gln Ala Ser Ala Ala Pro Pro           
    290                 295                 300                           

gag ccg gct gtc cat gct gct gcc ccc acc agc acc ctt cca tgc agc       1017
Glu Pro Ala Val His Ala Ala Ala Pro Thr Ser Thr Leu Pro Cys Ser           
305                 310                 315                 320           

ggt ggt gag ggg gct gga gcc gcc gcc aca gca ggt gtc cag gaa ccc       1065
Gly Gly Glu Gly Ala Gly Ala Ala Ala Thr Ala Gly Val Gln Glu Pro           
                325                 330                 335               

ggg gct cct ggc agt ggg gct caa gcc ggc cct ggt gga gac act tgg       1113
Gly Ala Pro Gly Ser Gly Ala Gln Ala Gly Pro Gly Gly Asp Thr Trp           
            340                 345                 350                   

gga gcc atc acc acg gaa caa aga act gac cct gca aac agc cag aag       1161
Gly Ala Ile Thr Thr Glu Gln Arg Thr Asp Pro Ala Asn Ser Gln Lys           
        355                 360                 365                       

gca tca ccc aaa aag atg ccc aag tca ggg ggc aag agc cgc ggg ccc       1209
Ala Ser Pro Lys Lys Met Pro Lys Ser Gly Gly Lys Ser Arg Gly Pro           
    370                 375                 380                           

ggg ggc agc tgt gag ttc tgc ggg aag cat ttt acc aac agc agc aac       1257
Gly Gly Ser Cys Glu Phe Cys Gly Lys His Phe Thr Asn Ser Ser Asn           
385                 390                 395                 400           

ctg acg gtg cac cgg cgc tca cac acc ggg gag cgc ccc tac acc tgt       1305
Leu Thr Val His Arg Arg Ser His Thr Gly Glu Arg Pro Tyr Thr Cys           
                405                 410                 415               

gag ttc tgc aac tac gcc tgc gcc cag agc agt aag ctc aac cgc cac       1353
Glu Phe Cys Asn Tyr Ala Cys Ala Gln Ser Ser Lys Leu Asn Arg His           
            420                 425                 430                   

cgc cgc atg cac ggc atg acg cct ggc agc acc cgc ttc gag tgc ccc       1401
Arg Arg Met His Gly Met Thr Pro Gly Ser Thr Arg Phe Glu Cys Pro           
        435                 440                 445                       

cac tgc cat gtg ccc ttc ggc ctg cga gcc acc ctg gac aaa cac ctg       1449
His Cys His Val Pro Phe Gly Leu Arg Ala Thr Leu Asp Lys His Leu           
    450                 455                 460                           

cgg cag aag cac cct gag gcg gcc ggc gag gcc tga gcccaggaaa            1495
Arg Gln Lys His Pro Glu Ala Ala Gly Glu Ala                               
465                 470                 475                               

gcccccctca ctgtccctgg taccgctgcc aacacccatt gacctcctcg tttttgcccg     1555

ccttctccaa gtaaattttc ccttttattt aaaaaaaaaa aaaaaaaaa                 1604


<210>  526
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  526

Met Ser Arg Arg Lys Ala Gly Ser Ala Pro Arg Arg Val Glu Pro Ala 
1               5                   10                  15      


Pro Ala Ala Asn Pro Asp Asp Glu Met Glu Met Gln Asp Leu Val Ile 
            20                  25                  30          


Glu Leu Lys Pro Glu Pro Asp Ala Gln Pro Gln Gln Ala Pro Arg Leu 
        35                  40                  45              


Gly Pro Phe Ser Pro Lys Glu Val Ser Ser Ala Gly Arg Phe Gly Gly 
    50                  55                  60                  


Glu Pro His His Ser Pro Gly Pro Met Pro Ala Gly Ala Ala Leu Leu 
65                  70                  75                  80  


Ala Leu Gly Pro Arg Asn Pro Trp Thr Leu Trp Thr Pro Leu Thr Pro 
                85                  90                  95      


Asn Tyr Pro Asp Arg Gln Pro Trp Thr Asp Lys His Pro Asp Leu Leu 
            100                 105                 110         


Thr Cys Gly Arg Cys Leu Gln Thr Phe Pro Leu Glu Ala Ile Thr Ala 
        115                 120                 125             


Phe Met Asp His Lys Lys Leu Gly Cys Gln Leu Phe Arg Gly Pro Ser 
    130                 135                 140                 


Arg Gly Gln Gly Ser Glu Arg Glu Glu Leu Lys Ala Leu Ser Cys Leu 
145                 150                 155                 160 


Arg Cys Gly Lys Gln Phe Thr Val Ala Trp Lys Leu Leu Arg His Ala 
                165                 170                 175     


Gln Trp Asp His Gly Leu Ser Ile Tyr Gln Thr Glu Ser Glu Ala Pro 
            180                 185                 190         


Glu Ala Pro Leu Leu Gly Leu Ala Glu Val Ala Ala Ala Val Ser Ala 
        195                 200                 205             


Val Val Gly Pro Ala Ala Glu Ala Lys Ser Pro Arg Ala Ser Gly Ser 
    210                 215                 220                 


Gly Leu Thr Arg Arg Ser Pro Thr Cys Pro Val Cys Lys Lys Thr Leu 
225                 230                 235                 240 


Ser Ser Phe Ser Asn Leu Lys Val His Met Arg Ser His Thr Gly Glu 
                245                 250                 255     


Arg Pro Tyr Ala Cys Asp Gln Cys Pro Tyr Ala Cys Ala Gln Ser Ser 
            260                 265                 270         


Lys Leu Asn Arg His Lys Lys Thr His Arg Gln Val Pro Pro Gln Ser 
        275                 280                 285             


Pro Leu Met Ala Asp Thr Ser Gln Glu Gln Ala Ser Ala Ala Pro Pro 
    290                 295                 300                 


Glu Pro Ala Val His Ala Ala Ala Pro Thr Ser Thr Leu Pro Cys Ser 
305                 310                 315                 320 


Gly Gly Glu Gly Ala Gly Ala Ala Ala Thr Ala Gly Val Gln Glu Pro 
                325                 330                 335     


Gly Ala Pro Gly Ser Gly Ala Gln Ala Gly Pro Gly Gly Asp Thr Trp 
            340                 345                 350         


Gly Ala Ile Thr Thr Glu Gln Arg Thr Asp Pro Ala Asn Ser Gln Lys 
        355                 360                 365             


Ala Ser Pro Lys Lys Met Pro Lys Ser Gly Gly Lys Ser Arg Gly Pro 
    370                 375                 380                 


Gly Gly Ser Cys Glu Phe Cys Gly Lys His Phe Thr Asn Ser Ser Asn 
385                 390                 395                 400 


Leu Thr Val His Arg Arg Ser His Thr Gly Glu Arg Pro Tyr Thr Cys 
                405                 410                 415     


Glu Phe Cys Asn Tyr Ala Cys Ala Gln Ser Ser Lys Leu Asn Arg His 
            420                 425                 430         


Arg Arg Met His Gly Met Thr Pro Gly Ser Thr Arg Phe Glu Cys Pro 
        435                 440                 445             


His Cys His Val Pro Phe Gly Leu Arg Ala Thr Leu Asp Lys His Leu 
    450                 455                 460                 


Arg Gln Lys His Pro Glu Ala Ala Gly Glu Ala 
465                 470                 475 


<210>  527
<211>  7219
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (102)..(5075)

<400>  527
ggaccccggc aagcccgcgc acttggcagg agctgtagct accgccgtcc gcgcctccaa       60

ggtttcacgg cttcctcagc agagactcgg gctcgtccgc c atg tcc gcc gca gac      116
                                              Met Ser Ala Ala Asp         
                                              1               5           

gag gtt gac ggg ctg ggc gtg gcc cgg ccg cac tat ggc tct gtc ctg        164
Glu Val Asp Gly Leu Gly Val Ala Arg Pro His Tyr Gly Ser Val Leu           
                10                  15                  20                

gat aat gaa aga ctt act gca gag gag atg gat gaa agg aga cgt cag        212
Asp Asn Glu Arg Leu Thr Ala Glu Glu Met Asp Glu Arg Arg Arg Gln           
            25                  30                  35                    

aac gtg gct tat gag tac ctt tgt cat ttg gaa gaa gcg aag agg tgg        260
Asn Val Ala Tyr Glu Tyr Leu Cys His Leu Glu Glu Ala Lys Arg Trp           
        40                  45                  50                        

atg gaa gca tgc cta ggg gaa gat ctg cct ccc acc aca gaa ctg gag        308
Met Glu Ala Cys Leu Gly Glu Asp Leu Pro Pro Thr Thr Glu Leu Glu           
    55                  60                  65                            

gag ggg ctt agg aat ggg gtc tac ctt gcc aaa ctg ggg aac ttc ttc        356
Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys Leu Gly Asn Phe Phe           
70                  75                  80                  85            

tct ccc aaa gta gtg tcc ctg aaa aaa atc tat gat cga gaa cag acc        404
Ser Pro Lys Val Val Ser Leu Lys Lys Ile Tyr Asp Arg Glu Gln Thr           
                90                  95                  100               

aga tac aag gcg act ggc ctc cac ttt aga cac act gat aat gtg att        452
Arg Tyr Lys Ala Thr Gly Leu His Phe Arg His Thr Asp Asn Val Ile           
            105                 110                 115                   

cag tgg ttg aat gcc atg gat gag att gga ttg cct aag att ttt tac        500
Gln Trp Leu Asn Ala Met Asp Glu Ile Gly Leu Pro Lys Ile Phe Tyr           
        120                 125                 130                       

cca gaa act aca gat atc tat gat cga aag aac atg cca aga tgt atc        548
Pro Glu Thr Thr Asp Ile Tyr Asp Arg Lys Asn Met Pro Arg Cys Ile           
    135                 140                 145                           

tac tgt atc cat gca ctc agt ttg tac ctg ttc aag cta ggc ctg gcc        596
Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe Lys Leu Gly Leu Ala           
150                 155                 160                 165           

cct cag att caa gac cta tat gga aag gtt gac ttc aca gaa gaa gaa        644
Pro Gln Ile Gln Asp Leu Tyr Gly Lys Val Asp Phe Thr Glu Glu Glu           
                170                 175                 180               

atc aac aac atg aag act gag ttg gag aag tat ggc atc cag atg cct        692
Ile Asn Asn Met Lys Thr Glu Leu Glu Lys Tyr Gly Ile Gln Met Pro           
            185                 190                 195                   

gcc ttt agc aag att ggg ggc atc ttg gct aat gaa ctg tca gtg gat        740
Ala Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn Glu Leu Ser Val Asp           
        200                 205                 210                       

gaa gcc gca tta cat gct gct gtt att gct att aat gaa gct att gac        788
Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile Asn Glu Ala Ile Asp           
    215                 220                 225                           

cgt aga att cca gcc gac aca ttt gca gct ttg aaa aat ccg aat gcc        836
Arg Arg Ile Pro Ala Asp Thr Phe Ala Ala Leu Lys Asn Pro Asn Ala           
230                 235                 240                 245           

atg ctt gta aat ctt gaa gag ccc ttg gca tcc act tac cag gat ata        884
Met Leu Val Asn Leu Glu Glu Pro Leu Ala Ser Thr Tyr Gln Asp Ile           
                250                 255                 260               

ctt tac cag gct aag cag gac aaa atg aca aat gct aaa aac agg aca        932
Leu Tyr Gln Ala Lys Gln Asp Lys Met Thr Asn Ala Lys Asn Arg Thr           
            265                 270                 275                   

gaa aac tca gag aga gaa aga gat gtt tat gag gag ctg ctc acg caa        980
Glu Asn Ser Glu Arg Glu Arg Asp Val Tyr Glu Glu Leu Leu Thr Gln           
        280                 285                 290                       

gct gaa att caa ggc aat ata aac aaa gtc aat aca ttt tct gca tta       1028
Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn Thr Phe Ser Ala Leu           
    295                 300                 305                           

gca aat atc gac ctg gct tta gaa caa gga gat gca ctg gcc ttg ttc       1076
Ala Asn Ile Asp Leu Ala Leu Glu Gln Gly Asp Ala Leu Ala Leu Phe           
310                 315                 320                 325           

agg gct ctg cag tca cca gcc ctg ggg ctt cga gga ctg cag caa cag       1124
Arg Ala Leu Gln Ser Pro Ala Leu Gly Leu Arg Gly Leu Gln Gln Gln           
                330                 335                 340               

aat agc gac tgg tac ttg aag cag ctc ctg agt gat aaa cag cag aag       1172
Asn Ser Asp Trp Tyr Leu Lys Gln Leu Leu Ser Asp Lys Gln Gln Lys           
            345                 350                 355                   

aga cag agt ggt cag act gac ccc ctg cag aag gag gag ctg cag tct       1220
Arg Gln Ser Gly Gln Thr Asp Pro Leu Gln Lys Glu Glu Leu Gln Ser           
        360                 365                 370                       

gga gtg gat gct gca aac agt gct gcc cag caa tat cag aga aga ttg       1268
Gly Val Asp Ala Ala Asn Ser Ala Ala Gln Gln Tyr Gln Arg Arg Leu           
    375                 380                 385                           

gca gca gta gca ctg att aat gct gca atc cag aag ggt gtt gct gag       1316
Ala Ala Val Ala Leu Ile Asn Ala Ala Ile Gln Lys Gly Val Ala Glu           
390                 395                 400                 405           

aag act gtt ttg gaa ctg atg aat ccc gaa gcc cag ctg ccc cag gtg       1364
Lys Thr Val Leu Glu Leu Met Asn Pro Glu Ala Gln Leu Pro Gln Val           
                410                 415                 420               

tat cca ttt gcc gcc gat ctc tat cag aag gag ctg gct acc ctg cag       1412
Tyr Pro Phe Ala Ala Asp Leu Tyr Gln Lys Glu Leu Ala Thr Leu Gln           
            425                 430                 435                   

cga caa agt cct gaa cat aat ctc acc cac cca gag ctc tct gtc gca       1460
Arg Gln Ser Pro Glu His Asn Leu Thr His Pro Glu Leu Ser Val Ala           
        440                 445                 450                       

gtg gag atg ttg tca tcg gtg gcc ctg atc aac agg gca ttg gaa tca       1508
Val Glu Met Leu Ser Ser Val Ala Leu Ile Asn Arg Ala Leu Glu Ser           
    455                 460                 465                           

gga gat gtg aat aca gtg tgg aag caa ttg agc agt tca gtt act ggt       1556
Gly Asp Val Asn Thr Val Trp Lys Gln Leu Ser Ser Ser Val Thr Gly           
470                 475                 480                 485           

ctt acc aat att gag gaa gaa aac tgt cag agg tat ctc gat gag ttg       1604
Leu Thr Asn Ile Glu Glu Glu Asn Cys Gln Arg Tyr Leu Asp Glu Leu           
                490                 495                 500               

atg aaa ctg aag gct cag gca cat gca gag aat aat gaa ttc att aca       1652
Met Lys Leu Lys Ala Gln Ala His Ala Glu Asn Asn Glu Phe Ile Thr           
            505                 510                 515                   

tgg aat gat atc caa gct tgc gtg gac cat gtg aac ctg gtg gtg caa       1700
Trp Asn Asp Ile Gln Ala Cys Val Asp His Val Asn Leu Val Val Gln           
        520                 525                 530                       

gag gaa cat gag agg att tta gcc att ggt tta att aat gaa gcc ctg       1748
Glu Glu His Glu Arg Ile Leu Ala Ile Gly Leu Ile Asn Glu Ala Leu           
    535                 540                 545                           

gat gaa ggt gat gcc caa aag act ctg cag gcc cta cag att cct gca       1796
Asp Glu Gly Asp Ala Gln Lys Thr Leu Gln Ala Leu Gln Ile Pro Ala           
550                 555                 560                 565           

gct aaa ctt gag gga gtc ctt gca gaa gtg gcc cag cat tac caa gac       1844
Ala Lys Leu Glu Gly Val Leu Ala Glu Val Ala Gln His Tyr Gln Asp           
                570                 575                 580               

acg ctg att aga gcg aag aga gag aaa gcc cag gaa atc cag gat gag       1892
Thr Leu Ile Arg Ala Lys Arg Glu Lys Ala Gln Glu Ile Gln Asp Glu           
            585                 590                 595                   

tca gct gtg tta tgg ttg gat gaa att caa ggt gga atc tgg cag tcc       1940
Ser Ala Val Leu Trp Leu Asp Glu Ile Gln Gly Gly Ile Trp Gln Ser           
        600                 605                 610                       

aac aaa gac acc caa gaa gca cag aag ttt gcc tta gga atc ttt gcc       1988
Asn Lys Asp Thr Gln Glu Ala Gln Lys Phe Ala Leu Gly Ile Phe Ala           
    615                 620                 625                           

att aat gag gca gta gaa agt ggt gat gtt ggc aaa aca ctg agt gcc       2036
Ile Asn Glu Ala Val Glu Ser Gly Asp Val Gly Lys Thr Leu Ser Ala           
630                 635                 640                 645           

ctt cgc tcc cct gat gtt ggc ttg tat gga gtc atc cct gag tgt ggt       2084
Leu Arg Ser Pro Asp Val Gly Leu Tyr Gly Val Ile Pro Glu Cys Gly           
                650                 655                 660               

gaa act tac cac agt gat ctt gct gaa gcc aag aag aaa aaa ctg gca       2132
Glu Thr Tyr His Ser Asp Leu Ala Glu Ala Lys Lys Lys Lys Leu Ala           
            665                 670                 675                   

gta gga gat aat aac agc aag tgg gtg aag cac tgg gta aaa ggt gga       2180
Val Gly Asp Asn Asn Ser Lys Trp Val Lys His Trp Val Lys Gly Gly           
        680                 685                 690                       

tat tat tat tac cac aat ctg gag acc cag gaa gga gga tgg gat gaa       2228
Tyr Tyr Tyr Tyr His Asn Leu Glu Thr Gln Glu Gly Gly Trp Asp Glu           
    695                 700                 705                           

cct cca aat ttt gtg caa aat tct atg cag ctt tct cgg gag gag atc       2276
Pro Pro Asn Phe Val Gln Asn Ser Met Gln Leu Ser Arg Glu Glu Ile           
710                 715                 720                 725           

cag agt tct atc tct ggg gtg act gcc gca tat aac cga gaa cag ctg       2324
Gln Ser Ser Ile Ser Gly Val Thr Ala Ala Tyr Asn Arg Glu Gln Leu           
                730                 735                 740               

tgg ctg gcc aat gaa ggc ctg atc acc agg ctg cag gct cgc tgc cgt       2372
Trp Leu Ala Asn Glu Gly Leu Ile Thr Arg Leu Gln Ala Arg Cys Arg           
            745                 750                 755                   

gga tac tta gtt cga cag gaa ttc cga tcc agg atg aat ttc ctg aag       2420
Gly Tyr Leu Val Arg Gln Glu Phe Arg Ser Arg Met Asn Phe Leu Lys           
        760                 765                 770                       

aaa caa atc cct gcc atc acc tgc att cag tca cag tgg aga gga tac       2468
Lys Gln Ile Pro Ala Ile Thr Cys Ile Gln Ser Gln Trp Arg Gly Tyr           
    775                 780                 785                           

aag cag aag aag gca tat caa gat cgg tta gct tac ctg cgc tcc cac       2516
Lys Gln Lys Lys Ala Tyr Gln Asp Arg Leu Ala Tyr Leu Arg Ser His           
790                 795                 800                 805           

aaa gat gaa gtt gta aag att cag tcc ctg gca agg atg cac caa gct       2564
Lys Asp Glu Val Val Lys Ile Gln Ser Leu Ala Arg Met His Gln Ala           
                810                 815                 820               

cga aag cgc tat cga gat cgc ctg cag tac ttc cgg gac cat ata aat       2612
Arg Lys Arg Tyr Arg Asp Arg Leu Gln Tyr Phe Arg Asp His Ile Asn           
            825                 830                 835                   

gac att atc aaa atc cag gct ttt att cgg gca aac aaa gct cgg gat       2660
Asp Ile Ile Lys Ile Gln Ala Phe Ile Arg Ala Asn Lys Ala Arg Asp           
        840                 845                 850                       

gac tac aag act ctc atc aat gct gag gat cct cct atg gtt gtg gtc       2708
Asp Tyr Lys Thr Leu Ile Asn Ala Glu Asp Pro Pro Met Val Val Val           
    855                 860                 865                           

cga aaa ttt gtc cac ctg ctg gac caa agt gac cag gat ttt cag gag       2756
Arg Lys Phe Val His Leu Leu Asp Gln Ser Asp Gln Asp Phe Gln Glu           
870                 875                 880                 885           

gag ctt gac ctt atg aag atg cgg gaa gag gtt atc acc ctc att cgt       2804
Glu Leu Asp Leu Met Lys Met Arg Glu Glu Val Ile Thr Leu Ile Arg           
                890                 895                 900               

tct aac cag cag ctg gag aat gac ctc aat ctc atg gat atc aaa att       2852
Ser Asn Gln Gln Leu Glu Asn Asp Leu Asn Leu Met Asp Ile Lys Ile           
            905                 910                 915                   

gga ctg cta gtg aaa aat aag att acg ttg cag gat gtg gtt tcc cac       2900
Gly Leu Leu Val Lys Asn Lys Ile Thr Leu Gln Asp Val Val Ser His           
        920                 925                 930                       

agt aaa aaa ctt acc aaa aaa aat aag gaa cag ttg tct gat atg atg       2948
Ser Lys Lys Leu Thr Lys Lys Asn Lys Glu Gln Leu Ser Asp Met Met           
    935                 940                 945                           

atg ata aat aaa cag aag gga ggt ctc aag gct ttg agc aag gag aag       2996
Met Ile Asn Lys Gln Lys Gly Gly Leu Lys Ala Leu Ser Lys Glu Lys           
950                 955                 960                 965           

aga gag aag ttg gaa gct tac cag cac ctg ttt tat tta ttg caa acc       3044
Arg Glu Lys Leu Glu Ala Tyr Gln His Leu Phe Tyr Leu Leu Gln Thr           
                970                 975                 980               

aat ccc acc tat ctg gcc aag ctc att ttt cag atg ccc cag aac aag       3092
Asn Pro Thr Tyr Leu Ala Lys Leu Ile Phe Gln Met Pro Gln Asn Lys           
            985                 990                 995                   

tcc acc aag  ttc atg gac tct gta  atc ttc aca ctc tac  aac tac        3137
Ser Thr Lys  Phe Met Asp Ser Val  Ile Phe Thr Leu Tyr  Asn Tyr            
        1000                 1005                 1010                    

gcg tcc aac  cag cga gag gag tac  ctg ctc ctg cgg ctc  ttt aag        3182
Ala Ser Asn  Gln Arg Glu Glu Tyr  Leu Leu Leu Arg Leu  Phe Lys            
        1015                 1020                 1025                    

aca gca ctc  caa gag gaa atc aag  tcg aag gta gat cag  att caa        3227
Thr Ala Leu  Gln Glu Glu Ile Lys  Ser Lys Val Asp Gln  Ile Gln            
        1030                 1035                 1040                    

gag att gtg  aca gga aat cct acg  gtt att aaa atg gtt  gta agt        3272
Glu Ile Val  Thr Gly Asn Pro Thr  Val Ile Lys Met Val  Val Ser            
        1045                 1050                 1055                    

ttc aac cgt  ggt gcc cgt ggc cag  aat gcc ctg aga cag  atc ttg        3317
Phe Asn Arg  Gly Ala Arg Gly Gln  Asn Ala Leu Arg Gln  Ile Leu            
        1060                 1065                 1070                    

gcc cca gtc  gtg aag gaa att atg  gat gac aaa tct ctc  aac atc        3362
Ala Pro Val  Val Lys Glu Ile Met  Asp Asp Lys Ser Leu  Asn Ile            
        1075                 1080                 1085                    

aaa act gac  cct gtg gat att tac  aaa tct tgg gtt aat  cag atg        3407
Lys Thr Asp  Pro Val Asp Ile Tyr  Lys Ser Trp Val Asn  Gln Met            
        1090                 1095                 1100                    

gag tct cag  aca gga gag gca agc  aaa ctg ccc tat gat  gtg acc        3452
Glu Ser Gln  Thr Gly Glu Ala Ser  Lys Leu Pro Tyr Asp  Val Thr            
        1105                 1110                 1115                    

cct gag cag  gcg cta gct cat gaa  gaa gtg aag aca cgg  cta gac        3497
Pro Glu Gln  Ala Leu Ala His Glu  Glu Val Lys Thr Arg  Leu Asp            
        1120                 1125                 1130                    

agc tcc atc  agg aac atg cgg gct  gtg aca gac aag ttt  ctc tca        3542
Ser Ser Ile  Arg Asn Met Arg Ala  Val Thr Asp Lys Phe  Leu Ser            
        1135                 1140                 1145                    

gcc att gtc  agc tct gtg gac aaa  atc cct tat ggg atg  cgc ttc        3587
Ala Ile Val  Ser Ser Val Asp Lys  Ile Pro Tyr Gly Met  Arg Phe            
        1150                 1155                 1160                    

att gcc aaa  gtg ctg aag gac tcg  ttg cat gag aag ttc  cct gat        3632
Ile Ala Lys  Val Leu Lys Asp Ser  Leu His Glu Lys Phe  Pro Asp            
        1165                 1170                 1175                    

gct ggt gag  gat gag ctg ctg aag  att att ggt aac ttg  ctt tat        3677
Ala Gly Glu  Asp Glu Leu Leu Lys  Ile Ile Gly Asn Leu  Leu Tyr            
        1180                 1185                 1190                    

tat cga tac  atg aat cca gcc att  gtt gct cct gat gcc  ttt gac        3722
Tyr Arg Tyr  Met Asn Pro Ala Ile  Val Ala Pro Asp Ala  Phe Asp            
        1195                 1200                 1205                    

atc att gac  ctg tca gca gga ggc  cag ctt acc aca gac  caa cgc        3767
Ile Ile Asp  Leu Ser Ala Gly Gly  Gln Leu Thr Thr Asp  Gln Arg            
        1210                 1215                 1220                    

cga aat ctg  ggc tcc att gca aaa  atg ctt cag cat gct  gct tcc        3812
Arg Asn Leu  Gly Ser Ile Ala Lys  Met Leu Gln His Ala  Ala Ser            
        1225                 1230                 1235                    

aat aag atg  ttt ctg gga gat aat  gcc cac tta agc atc  att aat        3857
Asn Lys Met  Phe Leu Gly Asp Asn  Ala His Leu Ser Ile  Ile Asn            
        1240                 1245                 1250                    

gaa tat ctt  tcc cag tcc tac cag  aaa ttc aga cgg ttt  ttc caa        3902
Glu Tyr Leu  Ser Gln Ser Tyr Gln  Lys Phe Arg Arg Phe  Phe Gln            
        1255                 1260                 1265                    

act gct tgt  gat gtc cca gag ctt  cag gat aaa ttt aat  gtg gat        3947
Thr Ala Cys  Asp Val Pro Glu Leu  Gln Asp Lys Phe Asn  Val Asp            
        1270                 1275                 1280                    

gag tac tct  gat tta gta acc ctc  acc aaa cca gta atc  tac att        3992
Glu Tyr Ser  Asp Leu Val Thr Leu  Thr Lys Pro Val Ile  Tyr Ile            
        1285                 1290                 1295                    

tcc att ggt  gaa atc atc aac acc  cac act ctc ctg ttg  gat cac        4037
Ser Ile Gly  Glu Ile Ile Asn Thr  His Thr Leu Leu Leu  Asp His            
        1300                 1305                 1310                    

cag gat gcc  att gct ccg gag cac  aat gat cca atc cac  gaa ctg        4082
Gln Asp Ala  Ile Ala Pro Glu His  Asn Asp Pro Ile His  Glu Leu            
        1315                 1320                 1325                    

ctg gac gac  ctc ggc gag gtg ccc  acc atc gag tcc ctg  ata ggg        4127
Leu Asp Asp  Leu Gly Glu Val Pro  Thr Ile Glu Ser Leu  Ile Gly            
        1330                 1335                 1340                    

gaa agc tct  ggc aat tta aat gac  cca aat aag gag gca  ctg gct        4172
Glu Ser Ser  Gly Asn Leu Asn Asp  Pro Asn Lys Glu Ala  Leu Ala            
        1345                 1350                 1355                    

aag acg gaa  gtg tct ctc acc ctg  acc aac aag ttc gac  gtg cct        4217
Lys Thr Glu  Val Ser Leu Thr Leu  Thr Asn Lys Phe Asp  Val Pro            
        1360                 1365                 1370                    

gga gat gag  aat gca gaa atg gat  gct cga acc atc tta  ctg aat        4262
Gly Asp Glu  Asn Ala Glu Met Asp  Ala Arg Thr Ile Leu  Leu Asn            
        1375                 1380                 1385                    

aca aaa cgt  tta att gtg gat gtc  atc cgg ttc cag cca  gga gag        4307
Thr Lys Arg  Leu Ile Val Asp Val  Ile Arg Phe Gln Pro  Gly Glu            
        1390                 1395                 1400                    

acc ttg act  gaa atc cta gaa aca  cca gcc acc agt gaa  cag gaa        4352
Thr Leu Thr  Glu Ile Leu Glu Thr  Pro Ala Thr Ser Glu  Gln Glu            
        1405                 1410                 1415                    

gca gaa cat  cag aga gcc atg cag  aga cgt gct atc cgt  gat gcc        4397
Ala Glu His  Gln Arg Ala Met Gln  Arg Arg Ala Ile Arg  Asp Ala            
        1420                 1425                 1430                    

aaa aca cct  gac aag atg aaa aag  tca aaa tct gta aag  gaa gac        4442
Lys Thr Pro  Asp Lys Met Lys Lys  Ser Lys Ser Val Lys  Glu Asp            
        1435                 1440                 1445                    

agc aac ctc  act ctt caa gag aag  aaa gag aag atc cag  aca ggt        4487
Ser Asn Leu  Thr Leu Gln Glu Lys  Lys Glu Lys Ile Gln  Thr Gly            
        1450                 1455                 1460                    

tta aag aag  cta aca gag ctt gga  acc gtg gac cca aag  aac aaa        4532
Leu Lys Lys  Leu Thr Glu Leu Gly  Thr Val Asp Pro Lys  Asn Lys            
        1465                 1470                 1475                    

tac cag gaa  ctg atc aac gac att  gcc agg gat att cgg  aat cag        4577
Tyr Gln Glu  Leu Ile Asn Asp Ile  Ala Arg Asp Ile Arg  Asn Gln            
        1480                 1485                 1490                    

cgg agg tac  cga cag agg aga aag  gcc gaa cta gtg aaa  ctg caa        4622
Arg Arg Tyr  Arg Gln Arg Arg Lys  Ala Glu Leu Val Lys  Leu Gln            
        1495                 1500                 1505                    

cag aca tac  gct gct ctg aac tct  aag gcc acc ttt tat  ggg gag        4667
Gln Thr Tyr  Ala Ala Leu Asn Ser  Lys Ala Thr Phe Tyr  Gly Glu            
        1510                 1515                 1520                    

cag gtg gat  tac tat aaa agc tat  atc aaa acc tgc ttg  gat aac        4712
Gln Val Asp  Tyr Tyr Lys Ser Tyr  Ile Lys Thr Cys Leu  Asp Asn            
        1525                 1530                 1535                    

tta gcc agc  aag ggc aaa gtc tcc  aaa aag cct agg gaa  atg aaa        4757
Leu Ala Ser  Lys Gly Lys Val Ser  Lys Lys Pro Arg Glu  Met Lys            
        1540                 1545                 1550                    

gga aag aaa  agc aaa aag att tct  ctg aaa tat aca gca  gca aga        4802
Gly Lys Lys  Ser Lys Lys Ile Ser  Leu Lys Tyr Thr Ala  Ala Arg            
        1555                 1560                 1565                    

cta cat gaa  aaa gga gtt ctt ctg  gaa att gag gac ctg  caa gtg        4847
Leu His Glu  Lys Gly Val Leu Leu  Glu Ile Glu Asp Leu  Gln Val            
        1570                 1575                 1580                    

aat cag ttt  aaa aat gtt ata ttt  gaa atc agt cca aca  gaa gaa        4892
Asn Gln Phe  Lys Asn Val Ile Phe  Glu Ile Ser Pro Thr  Glu Glu            
        1585                 1590                 1595                    

gtt gga gac  ttc gaa gtg aaa gcc  aaa ttc atg gga gtt  caa atg        4937
Val Gly Asp  Phe Glu Val Lys Ala  Lys Phe Met Gly Val  Gln Met            
        1600                 1605                 1610                    

gag act ttt  atg tta cat tat cag  gac ctg ctg cag cta  cag tat        4982
Glu Thr Phe  Met Leu His Tyr Gln  Asp Leu Leu Gln Leu  Gln Tyr            
        1615                 1620                 1625                    

gaa gga gtt  gca gtc atg aaa tta  ttt gat aga gct aaa  gta aat        5027
Glu Gly Val  Ala Val Met Lys Leu  Phe Asp Arg Ala Lys  Val Asn            
        1630                 1635                 1640                    

gtc aac ctc  ctg atc ttc ctt ctc  aac aaa aag ttc tac  ggg aag        5072
Val Asn Leu  Leu Ile Phe Leu Leu  Asn Lys Lys Phe Tyr  Gly Lys            
        1645                 1650                 1655                    

taa ttgatcgttt gctgccagcc cagaaggatg aaggaaagaa gcacctcaca            5125

gctcctttct aggtccttct ttcctcattg gaagcaaaga cctagccaac aacagcacct     5185

caatctgata cactcccgat gccacatttt taactcctct cgctctgatg ggacatttgt     5245

tacccttttt tcatagtgaa attgtgtttc aggcttagtc tgacctttct ggtttcttca     5305

ttttcttcca ttacttagga aagagtggaa actccactaa aatttctctg tgttgttaca     5365

gtcttagagg ttgcagtact atattgtaag ctttggtgtt tgtttaatta gcaataggga     5425

tggtaggatt caaatgtgtg tcatttagaa gtggaagcta ttagcaccaa tgacataaat     5485

acatacaaga cacacaacta aaatgtcatg ttattaacag ttattaggtt gtcatttaaa     5545

aataaagttc ctttatattt ctgtcccatc aggaaaactg aaggatatgg ggaatcattg     5605

gttatcttcc attgtgtttt tctttatgga caggagctaa tggaagtgac agtcatgttc     5665

aaaggaagca tttctagaaa aaaggagata atgtttttaa atttcattat caaacttggg     5725

caattctgtt tgtgtaactc cccgactagt ggatgggaga gtcccattgc taaaattcag     5785

ctactcagat aaattcagaa tgggtcaagg cacctgcctg tttttgttgg tgcacagaga     5845

ttgacttgat tcagagagac aattcactcc atccctatgg cagaggaatg ggttagccct     5905

aatgtagaat gtcattgttt ttaaaactgt tttatatctt aagagtgcct tattaaagta     5965

tagatgtatg tcttaaaatg tgggtgatag gaattttaaa gatttatata atgcatcaaa     6025

agccttagaa taagaaaagc tttttttaaa ttgctttatc tgtatatctg aactcttgaa     6085

acttatagct aaaacactag gatttatctg cagtgttcag ggagataatt ctgcctttaa     6145

ttgtctaaaa caaaaacaaa accagccaac ctatgttaca cgtgagatta aaaccaattt     6205

tttccccatt ttttctcctt ttttctcttg ctgcccacat tgtgccttta ttttatgagc     6265

cccagttttc tgggcttagt ttaaaaaaaa aatcaagtct aaacattgca tttagaaagc     6325

ttttgttctt ggataaaaag tcatacactt taaaaaaaaa aaaaactttt tccaggaaaa     6385

tatattgaaa tcatgctgct gagcctctat tttctttctt tgatgttttg attcagtatt     6445

cttttatcat aaatttttag catttaaaaa ttcactgatg tacattaagc caataaactg     6505

ctttaatgaa taacaaacta tgtagtgtgt ccctattata aatgcattgg agaagtattt     6565

ttatgagact ctttactcag gtgcatggtt acagcccaca gggaggcatg gagtgccatg     6625

gaaggattcg ccactaccca gaccttgttt tttgttgtat tttggaagac aggtttttta     6685

aagaaacatt ttcctcagat taaaagatga tgctattaca actagcattg cctcaaaaac     6745

tgggaccaac caaagtgtgt caaccctgtt tccttaaaag aggctatgaa tcccaaaggc     6805

cacatccaag acaggcaata atgagcagag tttacagctc ctttaataaa atgtgtcagt     6865

aattttaagg tttatagttc cctcaacaca attgctaatg cagaatagtg taaaatgcgc     6925

ttcaagaatg ttgatgatga tgatatagaa ttgtggcttt agtagcacag aggatgcccc     6985

aacaaactca tggcgttgaa accacacagt tctcattact gttatttatt agctgtagca     7045

ttctctgtct cctctctctc ctcctttgac cttctcctcg accagccatc atgacattta     7105

ccatgaattt acttcctccc aagagtttgg actgcccgtc agattgttgc tgcacatagt     7165

tgcctttgta tctctgtatg aaataaaagg tcatttgttc atgttaaaaa aaaa           7219


<210>  528
<211>  1657
<212>  PRT
<213>  Homo sapiens

<400>  528

Met Ser Ala Ala Asp Glu Val Asp Gly Leu Gly Val Ala Arg Pro His 
1               5                   10                  15      


Tyr Gly Ser Val Leu Asp Asn Glu Arg Leu Thr Ala Glu Glu Met Asp 
            20                  25                  30          


Glu Arg Arg Arg Gln Asn Val Ala Tyr Glu Tyr Leu Cys His Leu Glu 
        35                  40                  45              


Glu Ala Lys Arg Trp Met Glu Ala Cys Leu Gly Glu Asp Leu Pro Pro 
    50                  55                  60                  


Thr Thr Glu Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys 
65                  70                  75                  80  


Leu Gly Asn Phe Phe Ser Pro Lys Val Val Ser Leu Lys Lys Ile Tyr 
                85                  90                  95      


Asp Arg Glu Gln Thr Arg Tyr Lys Ala Thr Gly Leu His Phe Arg His 
            100                 105                 110         


Thr Asp Asn Val Ile Gln Trp Leu Asn Ala Met Asp Glu Ile Gly Leu 
        115                 120                 125             


Pro Lys Ile Phe Tyr Pro Glu Thr Thr Asp Ile Tyr Asp Arg Lys Asn 
    130                 135                 140                 


Met Pro Arg Cys Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe 
145                 150                 155                 160 


Lys Leu Gly Leu Ala Pro Gln Ile Gln Asp Leu Tyr Gly Lys Val Asp 
                165                 170                 175     


Phe Thr Glu Glu Glu Ile Asn Asn Met Lys Thr Glu Leu Glu Lys Tyr 
            180                 185                 190         


Gly Ile Gln Met Pro Ala Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn 
        195                 200                 205             


Glu Leu Ser Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile 
    210                 215                 220                 


Asn Glu Ala Ile Asp Arg Arg Ile Pro Ala Asp Thr Phe Ala Ala Leu 
225                 230                 235                 240 


Lys Asn Pro Asn Ala Met Leu Val Asn Leu Glu Glu Pro Leu Ala Ser 
                245                 250                 255     


Thr Tyr Gln Asp Ile Leu Tyr Gln Ala Lys Gln Asp Lys Met Thr Asn 
            260                 265                 270         


Ala Lys Asn Arg Thr Glu Asn Ser Glu Arg Glu Arg Asp Val Tyr Glu 
        275                 280                 285             


Glu Leu Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn 
    290                 295                 300                 


Thr Phe Ser Ala Leu Ala Asn Ile Asp Leu Ala Leu Glu Gln Gly Asp 
305                 310                 315                 320 


Ala Leu Ala Leu Phe Arg Ala Leu Gln Ser Pro Ala Leu Gly Leu Arg 
                325                 330                 335     


Gly Leu Gln Gln Gln Asn Ser Asp Trp Tyr Leu Lys Gln Leu Leu Ser 
            340                 345                 350         


Asp Lys Gln Gln Lys Arg Gln Ser Gly Gln Thr Asp Pro Leu Gln Lys 
        355                 360                 365             


Glu Glu Leu Gln Ser Gly Val Asp Ala Ala Asn Ser Ala Ala Gln Gln 
    370                 375                 380                 


Tyr Gln Arg Arg Leu Ala Ala Val Ala Leu Ile Asn Ala Ala Ile Gln 
385                 390                 395                 400 


Lys Gly Val Ala Glu Lys Thr Val Leu Glu Leu Met Asn Pro Glu Ala 
                405                 410                 415     


Gln Leu Pro Gln Val Tyr Pro Phe Ala Ala Asp Leu Tyr Gln Lys Glu 
            420                 425                 430         


Leu Ala Thr Leu Gln Arg Gln Ser Pro Glu His Asn Leu Thr His Pro 
        435                 440                 445             


Glu Leu Ser Val Ala Val Glu Met Leu Ser Ser Val Ala Leu Ile Asn 
    450                 455                 460                 


Arg Ala Leu Glu Ser Gly Asp Val Asn Thr Val Trp Lys Gln Leu Ser 
465                 470                 475                 480 


Ser Ser Val Thr Gly Leu Thr Asn Ile Glu Glu Glu Asn Cys Gln Arg 
                485                 490                 495     


Tyr Leu Asp Glu Leu Met Lys Leu Lys Ala Gln Ala His Ala Glu Asn 
            500                 505                 510         


Asn Glu Phe Ile Thr Trp Asn Asp Ile Gln Ala Cys Val Asp His Val 
        515                 520                 525             


Asn Leu Val Val Gln Glu Glu His Glu Arg Ile Leu Ala Ile Gly Leu 
    530                 535                 540                 


Ile Asn Glu Ala Leu Asp Glu Gly Asp Ala Gln Lys Thr Leu Gln Ala 
545                 550                 555                 560 


Leu Gln Ile Pro Ala Ala Lys Leu Glu Gly Val Leu Ala Glu Val Ala 
                565                 570                 575     


Gln His Tyr Gln Asp Thr Leu Ile Arg Ala Lys Arg Glu Lys Ala Gln 
            580                 585                 590         


Glu Ile Gln Asp Glu Ser Ala Val Leu Trp Leu Asp Glu Ile Gln Gly 
        595                 600                 605             


Gly Ile Trp Gln Ser Asn Lys Asp Thr Gln Glu Ala Gln Lys Phe Ala 
    610                 615                 620                 


Leu Gly Ile Phe Ala Ile Asn Glu Ala Val Glu Ser Gly Asp Val Gly 
625                 630                 635                 640 


Lys Thr Leu Ser Ala Leu Arg Ser Pro Asp Val Gly Leu Tyr Gly Val 
                645                 650                 655     


Ile Pro Glu Cys Gly Glu Thr Tyr His Ser Asp Leu Ala Glu Ala Lys 
            660                 665                 670         


Lys Lys Lys Leu Ala Val Gly Asp Asn Asn Ser Lys Trp Val Lys His 
        675                 680                 685             


Trp Val Lys Gly Gly Tyr Tyr Tyr Tyr His Asn Leu Glu Thr Gln Glu 
    690                 695                 700                 


Gly Gly Trp Asp Glu Pro Pro Asn Phe Val Gln Asn Ser Met Gln Leu 
705                 710                 715                 720 


Ser Arg Glu Glu Ile Gln Ser Ser Ile Ser Gly Val Thr Ala Ala Tyr 
                725                 730                 735     


Asn Arg Glu Gln Leu Trp Leu Ala Asn Glu Gly Leu Ile Thr Arg Leu 
            740                 745                 750         


Gln Ala Arg Cys Arg Gly Tyr Leu Val Arg Gln Glu Phe Arg Ser Arg 
        755                 760                 765             


Met Asn Phe Leu Lys Lys Gln Ile Pro Ala Ile Thr Cys Ile Gln Ser 
    770                 775                 780                 


Gln Trp Arg Gly Tyr Lys Gln Lys Lys Ala Tyr Gln Asp Arg Leu Ala 
785                 790                 795                 800 


Tyr Leu Arg Ser His Lys Asp Glu Val Val Lys Ile Gln Ser Leu Ala 
                805                 810                 815     


Arg Met His Gln Ala Arg Lys Arg Tyr Arg Asp Arg Leu Gln Tyr Phe 
            820                 825                 830         


Arg Asp His Ile Asn Asp Ile Ile Lys Ile Gln Ala Phe Ile Arg Ala 
        835                 840                 845             


Asn Lys Ala Arg Asp Asp Tyr Lys Thr Leu Ile Asn Ala Glu Asp Pro 
    850                 855                 860                 


Pro Met Val Val Val Arg Lys Phe Val His Leu Leu Asp Gln Ser Asp 
865                 870                 875                 880 


Gln Asp Phe Gln Glu Glu Leu Asp Leu Met Lys Met Arg Glu Glu Val 
                885                 890                 895     


Ile Thr Leu Ile Arg Ser Asn Gln Gln Leu Glu Asn Asp Leu Asn Leu 
            900                 905                 910         


Met Asp Ile Lys Ile Gly Leu Leu Val Lys Asn Lys Ile Thr Leu Gln 
        915                 920                 925             


Asp Val Val Ser His Ser Lys Lys Leu Thr Lys Lys Asn Lys Glu Gln 
    930                 935                 940                 


Leu Ser Asp Met Met Met Ile Asn Lys Gln Lys Gly Gly Leu Lys Ala 
945                 950                 955                 960 


Leu Ser Lys Glu Lys Arg Glu Lys Leu Glu Ala Tyr Gln His Leu Phe 
                965                 970                 975     


Tyr Leu Leu Gln Thr Asn Pro Thr Tyr Leu Ala Lys Leu Ile Phe Gln 
            980                 985                 990         


Met Pro Gln Asn Lys Ser Thr Lys  Phe Met Asp Ser Val  Ile Phe Thr 
        995                 1000                 1005             


Leu Tyr  Asn Tyr Ala Ser Asn  Gln Arg Glu Glu Tyr  Leu Leu Leu 
    1010                 1015                 1020             


Arg Leu  Phe Lys Thr Ala Leu  Gln Glu Glu Ile Lys  Ser Lys Val 
    1025                 1030                 1035             


Asp Gln  Ile Gln Glu Ile Val  Thr Gly Asn Pro Thr  Val Ile Lys 
    1040                 1045                 1050             


Met Val  Val Ser Phe Asn Arg  Gly Ala Arg Gly Gln  Asn Ala Leu 
    1055                 1060                 1065             


Arg Gln  Ile Leu Ala Pro Val  Val Lys Glu Ile Met  Asp Asp Lys 
    1070                 1075                 1080             


Ser Leu  Asn Ile Lys Thr Asp  Pro Val Asp Ile Tyr  Lys Ser Trp 
    1085                 1090                 1095             


Val Asn  Gln Met Glu Ser Gln  Thr Gly Glu Ala Ser  Lys Leu Pro 
    1100                 1105                 1110             


Tyr Asp  Val Thr Pro Glu Gln  Ala Leu Ala His Glu  Glu Val Lys 
    1115                 1120                 1125             


Thr Arg  Leu Asp Ser Ser Ile  Arg Asn Met Arg Ala  Val Thr Asp 
    1130                 1135                 1140             


Lys Phe  Leu Ser Ala Ile Val  Ser Ser Val Asp Lys  Ile Pro Tyr 
    1145                 1150                 1155             


Gly Met  Arg Phe Ile Ala Lys  Val Leu Lys Asp Ser  Leu His Glu 
    1160                 1165                 1170             


Lys Phe  Pro Asp Ala Gly Glu  Asp Glu Leu Leu Lys  Ile Ile Gly 
    1175                 1180                 1185             


Asn Leu  Leu Tyr Tyr Arg Tyr  Met Asn Pro Ala Ile  Val Ala Pro 
    1190                 1195                 1200             


Asp Ala  Phe Asp Ile Ile Asp  Leu Ser Ala Gly Gly  Gln Leu Thr 
    1205                 1210                 1215             


Thr Asp  Gln Arg Arg Asn Leu  Gly Ser Ile Ala Lys  Met Leu Gln 
    1220                 1225                 1230             


His Ala  Ala Ser Asn Lys Met  Phe Leu Gly Asp Asn  Ala His Leu 
    1235                 1240                 1245             


Ser Ile  Ile Asn Glu Tyr Leu  Ser Gln Ser Tyr Gln  Lys Phe Arg 
    1250                 1255                 1260             


Arg Phe  Phe Gln Thr Ala Cys  Asp Val Pro Glu Leu  Gln Asp Lys 
    1265                 1270                 1275             


Phe Asn  Val Asp Glu Tyr Ser  Asp Leu Val Thr Leu  Thr Lys Pro 
    1280                 1285                 1290             


Val Ile  Tyr Ile Ser Ile Gly  Glu Ile Ile Asn Thr  His Thr Leu 
    1295                 1300                 1305             


Leu Leu  Asp His Gln Asp Ala  Ile Ala Pro Glu His  Asn Asp Pro 
    1310                 1315                 1320             


Ile His  Glu Leu Leu Asp Asp  Leu Gly Glu Val Pro  Thr Ile Glu 
    1325                 1330                 1335             


Ser Leu  Ile Gly Glu Ser Ser  Gly Asn Leu Asn Asp  Pro Asn Lys 
    1340                 1345                 1350             


Glu Ala  Leu Ala Lys Thr Glu  Val Ser Leu Thr Leu  Thr Asn Lys 
    1355                 1360                 1365             


Phe Asp  Val Pro Gly Asp Glu  Asn Ala Glu Met Asp  Ala Arg Thr 
    1370                 1375                 1380             


Ile Leu  Leu Asn Thr Lys Arg  Leu Ile Val Asp Val  Ile Arg Phe 
    1385                 1390                 1395             


Gln Pro  Gly Glu Thr Leu Thr  Glu Ile Leu Glu Thr  Pro Ala Thr 
    1400                 1405                 1410             


Ser Glu  Gln Glu Ala Glu His  Gln Arg Ala Met Gln  Arg Arg Ala 
    1415                 1420                 1425             


Ile Arg  Asp Ala Lys Thr Pro  Asp Lys Met Lys Lys  Ser Lys Ser 
    1430                 1435                 1440             


Val Lys  Glu Asp Ser Asn Leu  Thr Leu Gln Glu Lys  Lys Glu Lys 
    1445                 1450                 1455             


Ile Gln  Thr Gly Leu Lys Lys  Leu Thr Glu Leu Gly  Thr Val Asp 
    1460                 1465                 1470             


Pro Lys  Asn Lys Tyr Gln Glu  Leu Ile Asn Asp Ile  Ala Arg Asp 
    1475                 1480                 1485             


Ile Arg  Asn Gln Arg Arg Tyr  Arg Gln Arg Arg Lys  Ala Glu Leu 
    1490                 1495                 1500             


Val Lys  Leu Gln Gln Thr Tyr  Ala Ala Leu Asn Ser  Lys Ala Thr 
    1505                 1510                 1515             


Phe Tyr  Gly Glu Gln Val Asp  Tyr Tyr Lys Ser Tyr  Ile Lys Thr 
    1520                 1525                 1530             


Cys Leu  Asp Asn Leu Ala Ser  Lys Gly Lys Val Ser  Lys Lys Pro 
    1535                 1540                 1545             


Arg Glu  Met Lys Gly Lys Lys  Ser Lys Lys Ile Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Thr Ala  Ala Arg Leu His Glu  Lys Gly Val Leu Leu  Glu Ile Glu 
    1565                 1570                 1575             


Asp Leu  Gln Val Asn Gln Phe  Lys Asn Val Ile Phe  Glu Ile Ser 
    1580                 1585                 1590             


Pro Thr  Glu Glu Val Gly Asp  Phe Glu Val Lys Ala  Lys Phe Met 
    1595                 1600                 1605             


Gly Val  Gln Met Glu Thr Phe  Met Leu His Tyr Gln  Asp Leu Leu 
    1610                 1615                 1620             


Gln Leu  Gln Tyr Glu Gly Val  Ala Val Met Lys Leu  Phe Asp Arg 
    1625                 1630                 1635             


Ala Lys  Val Asn Val Asn Leu  Leu Ile Phe Leu Leu  Asn Lys Lys 
    1640                 1645                 1650             


Phe Tyr  Gly Lys 
    1655         


<210>  529
<211>  513
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(513)

<400>  529
atg cgc cgc cgc ctg tgg ctg ggc ctg gcc tgg ctg ctg ctg gcg cgg         48
Met Arg Arg Arg Leu Trp Leu Gly Leu Ala Trp Leu Leu Leu Ala Arg           
1               5                   10                  15                

gcg ccg gac gcc gcg gga acc ccg agc gcg tcg cgg gga ccg cgc agc         96
Ala Pro Asp Ala Ala Gly Thr Pro Ser Ala Ser Arg Gly Pro Arg Ser           
            20                  25                  30                    

tac ccg cac ctg gag ggc gac gtg cgc tgg cgg cgc ctc ttc tcc tcc        144
Tyr Pro His Leu Glu Gly Asp Val Arg Trp Arg Arg Leu Phe Ser Ser           
        35                  40                  45                        

act cac ttc ttc ctg cgc gtg gat ccc ggc ggc cgc gtg cag ggc acc        192
Thr His Phe Phe Leu Arg Val Asp Pro Gly Gly Arg Val Gln Gly Thr           
    50                  55                  60                            

cgc tgg cgc cac ggc cag gac agc atc ctg gag atc cgc tct gta cac        240
Arg Trp Arg His Gly Gln Asp Ser Ile Leu Glu Ile Arg Ser Val His           
65                  70                  75                  80            

gtg ggc gtc gtg gtc atc aaa gca gtg tcc tca ggc ttc tac gtg gcc        288
Val Gly Val Val Val Ile Lys Ala Val Ser Ser Gly Phe Tyr Val Ala           
                85                  90                  95                

atg aac cgc cgg ggc cgc ctc tac ggg tcg cga ctc tac acc gtg gac        336
Met Asn Arg Arg Gly Arg Leu Tyr Gly Ser Arg Leu Tyr Thr Val Asp           
            100                 105                 110                   

tgc agg ttc cgg gag cgc atc gaa gag aac ggc cac aac acc tac gcc        384
Cys Arg Phe Arg Glu Arg Ile Glu Glu Asn Gly His Asn Thr Tyr Ala           
        115                 120                 125                       

tca cag cgc tgg cgc cgc cgc ggc cag ccc atg ttc ctg gcg ctg gac        432
Ser Gln Arg Trp Arg Arg Arg Gly Gln Pro Met Phe Leu Ala Leu Asp           
    130                 135                 140                           

agg agg ggg ggg ccc cgg cca ggc ggc cgg acg cgg cgg tac cac ctg        480
Arg Arg Gly Gly Pro Arg Pro Gly Gly Arg Thr Arg Arg Tyr His Leu           
145                 150                 155                 160           

tcc gcc cac ttc ctg ccc gtc ctg gtc tcc tga                            513
Ser Ala His Phe Leu Pro Val Leu Val Ser                                   
                165                 170                                   


<210>  530
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  530

Met Arg Arg Arg Leu Trp Leu Gly Leu Ala Trp Leu Leu Leu Ala Arg 
1               5                   10                  15      


Ala Pro Asp Ala Ala Gly Thr Pro Ser Ala Ser Arg Gly Pro Arg Ser 
            20                  25                  30          


Tyr Pro His Leu Glu Gly Asp Val Arg Trp Arg Arg Leu Phe Ser Ser 
        35                  40                  45              


Thr His Phe Phe Leu Arg Val Asp Pro Gly Gly Arg Val Gln Gly Thr 
    50                  55                  60                  


Arg Trp Arg His Gly Gln Asp Ser Ile Leu Glu Ile Arg Ser Val His 
65                  70                  75                  80  


Val Gly Val Val Val Ile Lys Ala Val Ser Ser Gly Phe Tyr Val Ala 
                85                  90                  95      


Met Asn Arg Arg Gly Arg Leu Tyr Gly Ser Arg Leu Tyr Thr Val Asp 
            100                 105                 110         


Cys Arg Phe Arg Glu Arg Ile Glu Glu Asn Gly His Asn Thr Tyr Ala 
        115                 120                 125             


Ser Gln Arg Trp Arg Arg Arg Gly Gln Pro Met Phe Leu Ala Leu Asp 
    130                 135                 140                 


Arg Arg Gly Gly Pro Arg Pro Gly Gly Arg Thr Arg Arg Tyr His Leu 
145                 150                 155                 160 


Ser Ala His Phe Leu Pro Val Leu Val Ser 
                165                 170 


<210>  531
<211>  3354
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (354)..(1871)

<400>  531
agacgttcgg tgatgggagc gcaatatatg aggggataca gtgcctcagg tttaaaagag       60

caggaagctg agtgagaggt tgcagaaaaa gtgtcttcgc tcggcagagg ttacaggtgg      120

catctcagaa agagctttga ggctacaggc tgtagtcggg aaggggatcg gagaactgtg      180

tgaagggaca gcttagggac tagcgtcctg ggactagggg gaagttcgcg actttctgaa      240

gactggcagg aatgtgcctc ctggccctcg atgcttcccc cctgagggga ggcatcgtga      300

gggactgtgg caggcttcac tgaacgctga gccggggagg tccaactcca cgt atg         356
                                                           Met            
                                                           1              

gat ccg ggg aat gag aat tca gcc aca gag gct gcc gcg atc ata gac        404
Asp Pro Gly Asn Glu Asn Ser Ala Thr Glu Ala Ala Ala Ile Ile Asp           
            5                   10                  15                    

cta gat ccc gac ttc gaa ccc cag agc cgt ccc cgc tcc tgc acc tgg        452
Leu Asp Pro Asp Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr Trp           
        20                  25                  30                        

ccc ctt ccc cga cca gag atc gct aac cag ccg tcc gag ccg ccc gag        500
Pro Leu Pro Arg Pro Glu Ile Ala Asn Gln Pro Ser Glu Pro Pro Glu           
    35                  40                  45                            

gtg gag cca gat ctg ggg gaa aag gta cac acg gag ggg cgc tca gag        548
Val Glu Pro Asp Leu Gly Glu Lys Val His Thr Glu Gly Arg Ser Glu           
50                  55                  60                  65            

ccg atc ctg ttg ccc tct cgg ctc cca gag ccg gcc ggg ggc ccc cag        596
Pro Ile Leu Leu Pro Ser Arg Leu Pro Glu Pro Ala Gly Gly Pro Gln           
                70                  75                  80                

ccc gga atc ctg ggg gct gta aca ggt cct cgg aag gga ggc tcc cgc        644
Pro Gly Ile Leu Gly Ala Val Thr Gly Pro Arg Lys Gly Gly Ser Arg           
            85                  90                  95                    

cgg aat gcc tgg gga aat cag tca tat gca gaa ctc atc agc cag gcc        692
Arg Asn Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu Ile Ser Gln Ala           
        100                 105                 110                       

att gaa agc gcc ccg gag aag cga ctg aca ctt gcc cag atc tac gag        740
Ile Glu Ser Ala Pro Glu Lys Arg Leu Thr Leu Ala Gln Ile Tyr Glu           
    115                 120                 125                           

tgg atg gtc cgt act gta ccc tac ttc aag gac aag ggt gac agc aac        788
Trp Met Val Arg Thr Val Pro Tyr Phe Lys Asp Lys Gly Asp Ser Asn           
130                 135                 140                 145           

agc tca gca gga tgg aag aac tcg atc cgc cac aac ctg tcc ctg cac        836
Ser Ser Ala Gly Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu His           
                150                 155                 160               

agc aag ttc atc aag gtt cac aac gag gcc acc ggc aaa agc tct tgg        884
Ser Lys Phe Ile Lys Val His Asn Glu Ala Thr Gly Lys Ser Ser Trp           
            165                 170                 175                   

tgg atg ctg aac cct gag gga ggc aag agc ggc aaa gcc ccc cgc cgc        932
Trp Met Leu Asn Pro Glu Gly Gly Lys Ser Gly Lys Ala Pro Arg Arg           
        180                 185                 190                       

cgg gcc gcc tcc atg gat agc agc agc aag ctg ctc cgg ggc cgc agt        980
Arg Ala Ala Ser Met Asp Ser Ser Ser Lys Leu Leu Arg Gly Arg Ser           
    195                 200                 205                           

aaa gcc ccc aag aag aaa cca tct gtg ctg cca gct cca ccc gaa ggt       1028
Lys Ala Pro Lys Lys Lys Pro Ser Val Leu Pro Ala Pro Pro Glu Gly           
210                 215                 220                 225           

gcc act cca acg agc cct gtc ggc cac ttt gcc aag tgg tca ggc agc       1076
Ala Thr Pro Thr Ser Pro Val Gly His Phe Ala Lys Trp Ser Gly Ser           
                230                 235                 240               

cct tgc tct cga aac cgt gaa gaa gcc gat atg tgg acc acc ttc cgt       1124
Pro Cys Ser Arg Asn Arg Glu Glu Ala Asp Met Trp Thr Thr Phe Arg           
            245                 250                 255                   

cca cga agc agt tca aat gcc agc agt gtc agc acc cgg ctg tcc ccc       1172
Pro Arg Ser Ser Ser Asn Ala Ser Ser Val Ser Thr Arg Leu Ser Pro           
        260                 265                 270                       

ttg agg cca gag tct gag gtg ctg gcg gag gaa ata cca gct tca gtc       1220
Leu Arg Pro Glu Ser Glu Val Leu Ala Glu Glu Ile Pro Ala Ser Val           
    275                 280                 285                           

agc agt tat gca ggg ggt gtc cct ccc acc ctc aat gaa ggt cta gag       1268
Ser Ser Tyr Ala Gly Gly Val Pro Pro Thr Leu Asn Glu Gly Leu Glu           
290                 295                 300                 305           

ctg tta gat ggg ctc aat ctc acc tct tcc cat tcc ctg cta tct cgg       1316
Leu Leu Asp Gly Leu Asn Leu Thr Ser Ser His Ser Leu Leu Ser Arg           
                310                 315                 320               

agt ggt ctc tct ggc ttc tct ttg cag cat cct ggg gtt acc ggc ccc       1364
Ser Gly Leu Ser Gly Phe Ser Leu Gln His Pro Gly Val Thr Gly Pro           
            325                 330                 335                   

tta cac acc tac agc agc tcc ctt ttc agc cca gca gag ggg ccc ctg       1412
Leu His Thr Tyr Ser Ser Ser Leu Phe Ser Pro Ala Glu Gly Pro Leu           
        340                 345                 350                       

tca gca gga gaa ggg tgc ttc tcc agc tcc cag gct ctg gag gcc ctg       1460
Ser Ala Gly Glu Gly Cys Phe Ser Ser Ser Gln Ala Leu Glu Ala Leu           
    355                 360                 365                           

ctc acc tct gat acg cca cca ccc cct gct gac gtc ctc atg acc cag       1508
Leu Thr Ser Asp Thr Pro Pro Pro Pro Ala Asp Val Leu Met Thr Gln           
370                 375                 380                 385           

gta gat ccc att ctg tcc cag gct ccg act ctt ctg ttg ctg ggg ggg       1556
Val Asp Pro Ile Leu Ser Gln Ala Pro Thr Leu Leu Leu Leu Gly Gly           
                390                 395                 400               

ctt cct tcc tcc agt aag ctg gcc acg ggc gtc ggc ctg tgt ccc aag       1604
Leu Pro Ser Ser Ser Lys Leu Ala Thr Gly Val Gly Leu Cys Pro Lys           
            405                 410                 415                   

ccc cta gag gct cca ggc ccc agc agt ctg gtt ccc acc ctt tct atg       1652
Pro Leu Glu Ala Pro Gly Pro Ser Ser Leu Val Pro Thr Leu Ser Met           
        420                 425                 430                       

ata gca cca cct cca gtc atg gca agt gcc ccc atc ccc aag gct ctg       1700
Ile Ala Pro Pro Pro Val Met Ala Ser Ala Pro Ile Pro Lys Ala Leu           
    435                 440                 445                           

ggg act cct gtg ctc aca ccc cct act gaa gct gca agc caa gac aga       1748
Gly Thr Pro Val Leu Thr Pro Pro Thr Glu Ala Ala Ser Gln Asp Arg           
450                 455                 460                 465           

atg cct cag gat cta gat ctt gat atg tat atg gag aac ctg gag tgt       1796
Met Pro Gln Asp Leu Asp Leu Asp Met Tyr Met Glu Asn Leu Glu Cys           
                470                 475                 480               

gac atg gat aac atc atc agt gac ctc atg gat gag ggc gag gga ctg       1844
Asp Met Asp Asn Ile Ile Ser Asp Leu Met Asp Glu Gly Glu Gly Leu           
            485                 490                 495                   

gac ttc aac ttt gag cca gat ccc tga gtcatgcctg gaagctttgt             1891
Asp Phe Asn Phe Glu Pro Asp Pro                                           
        500                 505                                           

cccctgcttc agatgtggag ccaggcgtgt tcatatctac tctttaccct tgagccctcc     1951

ccaggaattt gggaccctgc tttagagcta gggtggggtc tggtcacaca caggtgttga     2011

agaaattata aagataaagc tgccccatct ggggacgata tggggaggga gatgggaggg     2071

gaaaggggag agggtttttc tcactgtgcc aattaggggg taaggccccc tctcaggagc     2131

catcatcggc tttccccatt cctacccact taggctttgt agcaagatga gcaatgctgt     2191

tggaaatgtg aagtcaccag tggccttacc cctgcctttg ggagcaggat ttttttgtag     2251

agagtcttat ctgagctgag ccaggctagc tggagcctgg gatttctatg cagtggcccc     2311

ttaggccagt gatgtgcggt gggtgggctg tttaggggat ctggaagggc caaggtctga     2371

gcactggagt ggctcgccag gccaaatcac ccttagaagg ctgcagataa cagaaaggct     2431

ttttataaac ttttaaagaa atataaacac aaatatagag attttttaac catggcaggg     2491

tgctagtggt gggcagaatg cttttttttc tttctgaagg ctttgtgata gtgacatgat     2551

acaaacacta cagacaataa atattaggag acacagggaa gtggggagag gtggggagta     2611

atagtaaaca cagggaagag ctcccctacg gaccaggtat agagaaaggt ctatgcagaa     2671

ataggttaga gtttccctaa caaaaaagct aacccaggtc ccctcattcc ttcaacttgt     2731

gcctgggagt gtgtggtgtt agggtgcagc cacactcttc tatgacccag catgggttag     2791

tgctatggtg ggagagtaca ttgaaggcct ggaattagct tggggccagg gaagggactg     2851

ggaggggaga gaagagaagg agggaaggat ttaggatggt aaagttaggt acagagacct     2911

ccctgttcaa ggcccctgac agctgtccct gcccttcttc cccttccctg actgcagggg     2971

ttatgtggaa gtgtgtgtgg cagcaggcag cggggagggg aggaacaggg aagggggagc     3031

tggggagctt ggctgagggt ctgggaaatg agcagggatg gggggggatg tggatcaggt     3091

ttactagcac ctgccaggga ggccatctgg ggctccttct ccaccccagc ccccaaagca     3151

gcccttcccc cagtgccctt tgcatcgtcc cctcccccac ccctgctgtg ggttcccatc     3211

atttcctgtg tcagcgcctg gcctacccag attgtatcat gtgctagatt ggagtgggga     3271

agtgtgtcaa atcaataaat gaataaattc aataaatgcc tataaccagc agaaaaaaaa     3331

aaaaaaaaaa aaaaaaaaaa aaa                                             3354


<210>  532
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  532

Met Asp Pro Gly Asn Glu Asn Ser Ala Thr Glu Ala Ala Ala Ile Ile 
1               5                   10                  15      


Asp Leu Asp Pro Asp Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr 
            20                  25                  30          


Trp Pro Leu Pro Arg Pro Glu Ile Ala Asn Gln Pro Ser Glu Pro Pro 
        35                  40                  45              


Glu Val Glu Pro Asp Leu Gly Glu Lys Val His Thr Glu Gly Arg Ser 
    50                  55                  60                  


Glu Pro Ile Leu Leu Pro Ser Arg Leu Pro Glu Pro Ala Gly Gly Pro 
65                  70                  75                  80  


Gln Pro Gly Ile Leu Gly Ala Val Thr Gly Pro Arg Lys Gly Gly Ser 
                85                  90                  95      


Arg Arg Asn Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu Ile Ser Gln 
            100                 105                 110         


Ala Ile Glu Ser Ala Pro Glu Lys Arg Leu Thr Leu Ala Gln Ile Tyr 
        115                 120                 125             


Glu Trp Met Val Arg Thr Val Pro Tyr Phe Lys Asp Lys Gly Asp Ser 
    130                 135                 140                 


Asn Ser Ser Ala Gly Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu 
145                 150                 155                 160 


His Ser Lys Phe Ile Lys Val His Asn Glu Ala Thr Gly Lys Ser Ser 
                165                 170                 175     


Trp Trp Met Leu Asn Pro Glu Gly Gly Lys Ser Gly Lys Ala Pro Arg 
            180                 185                 190         


Arg Arg Ala Ala Ser Met Asp Ser Ser Ser Lys Leu Leu Arg Gly Arg 
        195                 200                 205             


Ser Lys Ala Pro Lys Lys Lys Pro Ser Val Leu Pro Ala Pro Pro Glu 
    210                 215                 220                 


Gly Ala Thr Pro Thr Ser Pro Val Gly His Phe Ala Lys Trp Ser Gly 
225                 230                 235                 240 


Ser Pro Cys Ser Arg Asn Arg Glu Glu Ala Asp Met Trp Thr Thr Phe 
                245                 250                 255     


Arg Pro Arg Ser Ser Ser Asn Ala Ser Ser Val Ser Thr Arg Leu Ser 
            260                 265                 270         


Pro Leu Arg Pro Glu Ser Glu Val Leu Ala Glu Glu Ile Pro Ala Ser 
        275                 280                 285             


Val Ser Ser Tyr Ala Gly Gly Val Pro Pro Thr Leu Asn Glu Gly Leu 
    290                 295                 300                 


Glu Leu Leu Asp Gly Leu Asn Leu Thr Ser Ser His Ser Leu Leu Ser 
305                 310                 315                 320 


Arg Ser Gly Leu Ser Gly Phe Ser Leu Gln His Pro Gly Val Thr Gly 
                325                 330                 335     


Pro Leu His Thr Tyr Ser Ser Ser Leu Phe Ser Pro Ala Glu Gly Pro 
            340                 345                 350         


Leu Ser Ala Gly Glu Gly Cys Phe Ser Ser Ser Gln Ala Leu Glu Ala 
        355                 360                 365             


Leu Leu Thr Ser Asp Thr Pro Pro Pro Pro Ala Asp Val Leu Met Thr 
    370                 375                 380                 


Gln Val Asp Pro Ile Leu Ser Gln Ala Pro Thr Leu Leu Leu Leu Gly 
385                 390                 395                 400 


Gly Leu Pro Ser Ser Ser Lys Leu Ala Thr Gly Val Gly Leu Cys Pro 
                405                 410                 415     


Lys Pro Leu Glu Ala Pro Gly Pro Ser Ser Leu Val Pro Thr Leu Ser 
            420                 425                 430         


Met Ile Ala Pro Pro Pro Val Met Ala Ser Ala Pro Ile Pro Lys Ala 
        435                 440                 445             


Leu Gly Thr Pro Val Leu Thr Pro Pro Thr Glu Ala Ala Ser Gln Asp 
    450                 455                 460                 


Arg Met Pro Gln Asp Leu Asp Leu Asp Met Tyr Met Glu Asn Leu Glu 
465                 470                 475                 480 


Cys Asp Met Asp Asn Ile Ile Ser Asp Leu Met Asp Glu Gly Glu Gly 
                485                 490                 495     


Leu Asp Phe Asn Phe Glu Pro Asp Pro 
            500                 505 


<210>  533
<211>  2377
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (63)..(1145)

<400>  533
gaaccctgaa gtcggtgtct gctgcgttca cggcaggatt cggttaggag gaacagcaca       60

gc atg ctg ggc tct gga ttt aaa gct gag cgc tta aga gtg aat ttg         107
   Met Leu Gly Ser Gly Phe Lys Ala Glu Arg Leu Arg Val Asn Leu            
   1               5                   10                  15             

aga tta gtc ata aat cgc ctt aaa cta ttg gag aaa aag aaa acg gaa        155
Arg Leu Val Ile Asn Arg Leu Lys Leu Leu Glu Lys Lys Lys Thr Glu           
                20                  25                  30                

ctg gcc cag aaa gca agg aag gag att gct gac tat ctg gct gct ggg        203
Leu Ala Gln Lys Ala Arg Lys Glu Ile Ala Asp Tyr Leu Ala Ala Gly           
            35                  40                  45                    

aaa gat gaa cga gct cgg atc cgt gtg gag cac att atc cgg gaa gac        251
Lys Asp Glu Arg Ala Arg Ile Arg Val Glu His Ile Ile Arg Glu Asp           
        50                  55                  60                        

tac ctc gtg gag gcc atg gag atc ctg gag ctg tac tgt gac ctg ctg        299
Tyr Leu Val Glu Ala Met Glu Ile Leu Glu Leu Tyr Cys Asp Leu Leu           
    65                  70                  75                            

ctg gct cgg ttt ggc ctt atc cag tct atg aag gaa cta gat tct ggt        347
Leu Ala Arg Phe Gly Leu Ile Gln Ser Met Lys Glu Leu Asp Ser Gly           
80                  85                  90                  95            

ctg gct gaa tct gtg tct aca ttg atc tgg gct gct cct cga ctc cag        395
Leu Ala Glu Ser Val Ser Thr Leu Ile Trp Ala Ala Pro Arg Leu Gln           
                100                 105                 110               

tca gaa gtg gct gag ttg aaa ata gtt gct gat cag ctc tgt gcc aag        443
Ser Glu Val Ala Glu Leu Lys Ile Val Ala Asp Gln Leu Cys Ala Lys           
            115                 120                 125                   

tat agc aag gaa tat ggc aag cta tgt agg acc aac cag att gga act        491
Tyr Ser Lys Glu Tyr Gly Lys Leu Cys Arg Thr Asn Gln Ile Gly Thr           
        130                 135                 140                       

gtg aat gac agg cta atg cac aag ctg agt gtg gaa gcc cca ccc aaa        539
Val Asn Asp Arg Leu Met His Lys Leu Ser Val Glu Ala Pro Pro Lys           
    145                 150                 155                           

atc ctg gtg gag aga tac ctg att gaa att gca aag aat tac aac gta        587
Ile Leu Val Glu Arg Tyr Leu Ile Glu Ile Ala Lys Asn Tyr Asn Val           
160                 165                 170                 175           

ccc tat gaa cct gac tct gtg gtc atg gca gaa gct cct cct ggg gta        635
Pro Tyr Glu Pro Asp Ser Val Val Met Ala Glu Ala Pro Pro Gly Val           
                180                 185                 190               

gag aca gat ctt att gat gtt gga ttc aca gat gat gtg aag aaa gga        683
Glu Thr Asp Leu Ile Asp Val Gly Phe Thr Asp Asp Val Lys Lys Gly           
            195                 200                 205                   

ggc cct gga aga gga ggg agt ggt ggc ttc aca gca cca gtt ggt gga        731
Gly Pro Gly Arg Gly Gly Ser Gly Gly Phe Thr Ala Pro Val Gly Gly           
        210                 215                 220                       

cct gat gga acg gtg cca atg ccc atg ccc atg ccc atg cct atg cca        779
Pro Asp Gly Thr Val Pro Met Pro Met Pro Met Pro Met Pro Met Pro           
    225                 230                 235                           

tct gca aat acg cct ttc tca tat cca ctg cca aag gga cca tca gat        827
Ser Ala Asn Thr Pro Phe Ser Tyr Pro Leu Pro Lys Gly Pro Ser Asp           
240                 245                 250                 255           

ttc aat gga ctg cca atg ggg act tat cag gcc ttt ccc aat att cat        875
Phe Asn Gly Leu Pro Met Gly Thr Tyr Gln Ala Phe Pro Asn Ile His           
                260                 265                 270               

cca cct cag ata cca gca act ccc cca tcg tat gaa tct atg aca tta        923
Pro Pro Gln Ile Pro Ala Thr Pro Pro Ser Tyr Glu Ser Met Thr Leu           
            275                 280                 285                   

atg ctg ata aga ata tct ctt ctg cac aga ttg ttg gtc ctg gac cca        971
Met Leu Ile Arg Ile Ser Leu Leu His Arg Leu Leu Val Leu Asp Pro           
        290                 295                 300                       

agc cag aag cct ctg caa agc ttc ctt cca gac ctg cag ata act atg       1019
Ser Gln Lys Pro Leu Gln Ser Phe Leu Pro Asp Leu Gln Ile Thr Met           
    305                 310                 315                           

aca act ttg tcc tac cag agt tgc cat ctg tgc cag aca cac tac caa       1067
Thr Thr Leu Ser Tyr Gln Ser Cys His Leu Cys Gln Thr His Tyr Gln           
320                 325                 330                 335           

ctg cat ctg ctg gtg cca gca cct cag cat ctg aag aca ttg act ttg       1115
Leu His Leu Leu Val Pro Ala Pro Gln His Leu Lys Thr Leu Thr Leu           
                340                 345                 350               

atg atc ttt ccc gga ggt ttg aag agc tga aaaagaaaac ataggtctct         1165
Met Ile Phe Pro Gly Gly Leu Lys Ser                                       
            355                 360                                       

taaaccaggc aactttcacg ttttgggagt tgagactgag caatttctcc ttgtaacaaa     1225

gaatctccat gaaattctgt ttcatctgtt aaccgtcact cagcacaaca ctccctctgg     1285

gctctcttcc tgctcctcca gattctgctg ctttccagtt ctctgttgat cctgagacta     1345

acaattggag actgaggcca gagcaactgg ctcctggcag ctgtgcttgt ccgtttcctg     1405

tcagagtgat cccaggtttc ctcctggccc gtcccatggt ccctccacag gagtgtgaga     1465

ggatggggga agcactgtgg gaagaccacc aaagatggct ggacagtggg agagagcacg     1525

ttgtgaagca tcccagcctc gtgttgaggt tccagactta gaaacagacc cctctgtaca     1585

gggggattgt ggtgagtgag aatcaaggcc accttgtgtg ttttctcact ctcgaatgca     1645

agtgggagag ggaaaatgac tcgggacgcc attgtaacgg ttcctggaag ctgggccctc     1705

tcattggcat atacagtact cctcgctgca gggcactgtc ccaccgggat ccagttgcaa     1765

agtttgtctt gacagttgaa ggcctcgctt agttgtactg gattctcagg gagccctctg     1825

tggccttttg ctttgcgtgc tgtttccctt gtaccagagg gcggcaccgt ggaaattctg     1885

ttttccctgt agcatattgt gttggattgc attactggca gagaaaggac aaggtgccat     1945

tcaagtccta gggtgggctt ccagctgcct taatagaagt actcaagtct tttgggtagt     2005

gagctggaaa gcctacagga aaagaggggt acctgttttc atttgaaaac tttgattcat     2065

ggaaccttta aaactaatct cagaaaaatt tttggtgccc atgcagctgt agttgttcac     2125

tgctttcctg gatggatggg actcttatgt cataacttct gttactcctt tggcccatag     2185

ctaaggtcat ccttccccac aggggtggct ttgggattgg atgatacagc ttttgcttct     2245

gtgtagtata cctgtacata cttgtttcag gcagcctttc tttaatgttt tcagttggtt     2305

tgtattctgt agctcagtag ctgctaataa agttaaagat cctgaaaaaa aaaaaaaaaa     2365

aaaaaaaaaa aa                                                         2377


<210>  534
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  534

Met Leu Gly Ser Gly Phe Lys Ala Glu Arg Leu Arg Val Asn Leu Arg 
1               5                   10                  15      


Leu Val Ile Asn Arg Leu Lys Leu Leu Glu Lys Lys Lys Thr Glu Leu 
            20                  25                  30          


Ala Gln Lys Ala Arg Lys Glu Ile Ala Asp Tyr Leu Ala Ala Gly Lys 
        35                  40                  45              


Asp Glu Arg Ala Arg Ile Arg Val Glu His Ile Ile Arg Glu Asp Tyr 
    50                  55                  60                  


Leu Val Glu Ala Met Glu Ile Leu Glu Leu Tyr Cys Asp Leu Leu Leu 
65                  70                  75                  80  


Ala Arg Phe Gly Leu Ile Gln Ser Met Lys Glu Leu Asp Ser Gly Leu 
                85                  90                  95      


Ala Glu Ser Val Ser Thr Leu Ile Trp Ala Ala Pro Arg Leu Gln Ser 
            100                 105                 110         


Glu Val Ala Glu Leu Lys Ile Val Ala Asp Gln Leu Cys Ala Lys Tyr 
        115                 120                 125             


Ser Lys Glu Tyr Gly Lys Leu Cys Arg Thr Asn Gln Ile Gly Thr Val 
    130                 135                 140                 


Asn Asp Arg Leu Met His Lys Leu Ser Val Glu Ala Pro Pro Lys Ile 
145                 150                 155                 160 


Leu Val Glu Arg Tyr Leu Ile Glu Ile Ala Lys Asn Tyr Asn Val Pro 
                165                 170                 175     


Tyr Glu Pro Asp Ser Val Val Met Ala Glu Ala Pro Pro Gly Val Glu 
            180                 185                 190         


Thr Asp Leu Ile Asp Val Gly Phe Thr Asp Asp Val Lys Lys Gly Gly 
        195                 200                 205             


Pro Gly Arg Gly Gly Ser Gly Gly Phe Thr Ala Pro Val Gly Gly Pro 
    210                 215                 220                 


Asp Gly Thr Val Pro Met Pro Met Pro Met Pro Met Pro Met Pro Ser 
225                 230                 235                 240 


Ala Asn Thr Pro Phe Ser Tyr Pro Leu Pro Lys Gly Pro Ser Asp Phe 
                245                 250                 255     


Asn Gly Leu Pro Met Gly Thr Tyr Gln Ala Phe Pro Asn Ile His Pro 
            260                 265                 270         


Pro Gln Ile Pro Ala Thr Pro Pro Ser Tyr Glu Ser Met Thr Leu Met 
        275                 280                 285             


Leu Ile Arg Ile Ser Leu Leu His Arg Leu Leu Val Leu Asp Pro Ser 
    290                 295                 300                 


Gln Lys Pro Leu Gln Ser Phe Leu Pro Asp Leu Gln Ile Thr Met Thr 
305                 310                 315                 320 


Thr Leu Ser Tyr Gln Ser Cys His Leu Cys Gln Thr His Tyr Gln Leu 
                325                 330                 335     


His Leu Leu Val Pro Ala Pro Gln His Leu Lys Thr Leu Thr Leu Met 
            340                 345                 350         


Ile Phe Pro Gly Gly Leu Lys Ser 
        355                 360 


<210>  535
<211>  431
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(315)

<400>  535
atg gca cct acg gcc ctg acc gga gag agg gaa gga aac atc tgt gct         48
Met Ala Pro Thr Ala Leu Thr Gly Glu Arg Glu Gly Asn Ile Cys Ala           
1               5                   10                  15                

ggg gcc tgc tcc ctc tgc ccc agc act ggg gaa tca ctg cct tcc tgg         96
Gly Ala Cys Ser Leu Cys Pro Ser Thr Gly Glu Ser Leu Pro Ser Trp           
            20                  25                  30                    

ctg ctg cca cat acc aca atc tcc tct gct gga gag gag agg atg tgt        144
Leu Leu Pro His Thr Thr Ile Ser Ser Ala Gly Glu Glu Arg Met Cys           
        35                  40                  45                        

tcc tcc cag gcc acg ggg ccc ctc tgc ctt gcc cca agc aca gag cta        192
Ser Ser Gln Ala Thr Gly Pro Leu Cys Leu Ala Pro Ser Thr Glu Leu           
    50                  55                  60                            

cct aag gga ctg acc ttt gcc aca ctg gag ctc acc tcc cgg ggg cct        240
Pro Lys Gly Leu Thr Phe Ala Thr Leu Glu Leu Thr Ser Arg Gly Pro           
65                  70                  75                  80            

ctg gcc tac cct ttt ccc tgc cag ctg aag aga ctg ccg gca gcc tgg        288
Leu Ala Tyr Pro Phe Pro Cys Gln Leu Lys Arg Leu Pro Ala Ala Trp           
                85                  90                  95                

acg tcc tgg tta gct gaa ggc agc tga aatgtgggcc tccctatgtg              335
Thr Ser Trp Leu Ala Glu Gly Ser                                           
            100                                                           

gggtttagta ctgaattatg tgtttgtggt tttgcttctt tttgtagacc cacaaatatt      395

tttatttgaa tagtaaagag ctgtgctcag attgta                                431


<210>  536
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  536

Met Ala Pro Thr Ala Leu Thr Gly Glu Arg Glu Gly Asn Ile Cys Ala 
1               5                   10                  15      


Gly Ala Cys Ser Leu Cys Pro Ser Thr Gly Glu Ser Leu Pro Ser Trp 
            20                  25                  30          


Leu Leu Pro His Thr Thr Ile Ser Ser Ala Gly Glu Glu Arg Met Cys 
        35                  40                  45              


Ser Ser Gln Ala Thr Gly Pro Leu Cys Leu Ala Pro Ser Thr Glu Leu 
    50                  55                  60                  


Pro Lys Gly Leu Thr Phe Ala Thr Leu Glu Leu Thr Ser Arg Gly Pro 
65                  70                  75                  80  


Leu Ala Tyr Pro Phe Pro Cys Gln Leu Lys Arg Leu Pro Ala Ala Trp 
                85                  90                  95      


Thr Ser Trp Leu Ala Glu Gly Ser 
            100                 


<210>  537
<211>  4435
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (153)..(4235)

<400>  537
ggcgaggcgc ctgttgattg gccactgggg cccgggttcc tccggcggag cgcgcctccc       60

cccagatttc ccgccagcag gagccgcgcg gtagatgcgg tgcttttagg agctccgtcc      120

gacagaacgg ttgggccttg ccggctgtcg gt atg tcg cga cag agc acc ctg        173
                                    Met Ser Arg Gln Ser Thr Leu           
                                    1               5                     

tac agc ttc ttc ccc aag tct ccg gcg ctg agt gat gcc aac aag gcc        221
Tyr Ser Phe Phe Pro Lys Ser Pro Ala Leu Ser Asp Ala Asn Lys Ala           
        10                  15                  20                        

tcg gcc agg gcc tca cgc gaa ggc ggc cgt gcc gcc gct gcc ccc ggg        269
Ser Ala Arg Ala Ser Arg Glu Gly Gly Arg Ala Ala Ala Ala Pro Gly           
    25                  30                  35                            

gcc tct cct tcc cca ggc ggg gat gcg gcc tgg agc gag gct ggg cct        317
Ala Ser Pro Ser Pro Gly Gly Asp Ala Ala Trp Ser Glu Ala Gly Pro           
40                  45                  50                  55            

ggg ccc agg ccc ttg gcg cgc tcc gcg tca ccg ccc aag gcg aag aac        365
Gly Pro Arg Pro Leu Ala Arg Ser Ala Ser Pro Pro Lys Ala Lys Asn           
                60                  65                  70                

ctc aac gga ggg ctg cgg aga tcg gta gcg cct gct gcc ccc acc agt        413
Leu Asn Gly Gly Leu Arg Arg Ser Val Ala Pro Ala Ala Pro Thr Ser           
            75                  80                  85                    

tgt gac ttc tca cca gga gat ttg gtt tgg gcc aag atg gag ggt tac        461
Cys Asp Phe Ser Pro Gly Asp Leu Val Trp Ala Lys Met Glu Gly Tyr           
        90                  95                  100                       

ccc tgg tgg cct tgt ctg gtt tac aac cac ccc ttt gat gga aca ttc        509
Pro Trp Trp Pro Cys Leu Val Tyr Asn His Pro Phe Asp Gly Thr Phe           
    105                 110                 115                           

atc cgc gag aaa ggg aaa tca gtc cgt gtt cat gta cag ttt ttt gat        557
Ile Arg Glu Lys Gly Lys Ser Val Arg Val His Val Gln Phe Phe Asp           
120                 125                 130                 135           

gac agc cca aca agg ggc tgg gtt agc aaa agg ctt tta aag cca tat        605
Asp Ser Pro Thr Arg Gly Trp Val Ser Lys Arg Leu Leu Lys Pro Tyr           
                140                 145                 150               

aca ggt tca aaa tca aag gaa gcc cag aag gga ggt cat ttt tac agt        653
Thr Gly Ser Lys Ser Lys Glu Ala Gln Lys Gly Gly His Phe Tyr Ser           
            155                 160                 165                   

gca aag cct gaa ata ctg aga gca atg caa cgt gca gat gaa gcc tta        701
Ala Lys Pro Glu Ile Leu Arg Ala Met Gln Arg Ala Asp Glu Ala Leu           
        170                 175                 180                       

aat aaa gac aag att aag agg ctt gaa ttg gca gtt tgt gat gag ccc        749
Asn Lys Asp Lys Ile Lys Arg Leu Glu Leu Ala Val Cys Asp Glu Pro           
    185                 190                 195                           

tca gag cca gaa gag gaa gaa gag atg gag gta ggc aca act tac gta        797
Ser Glu Pro Glu Glu Glu Glu Glu Met Glu Val Gly Thr Thr Tyr Val           
200                 205                 210                 215           

aca gat aag agt gaa gaa gat aat gaa att gag agt gaa gag gaa gta        845
Thr Asp Lys Ser Glu Glu Asp Asn Glu Ile Glu Ser Glu Glu Glu Val           
                220                 225                 230               

cag cct aag aca caa gga tct agg cga agt agc cgc caa ata aaa aaa        893
Gln Pro Lys Thr Gln Gly Ser Arg Arg Ser Ser Arg Gln Ile Lys Lys           
            235                 240                 245                   

cga agg gtc ata tca gat tct gag agt gac att ggt ggc tct gat gtg        941
Arg Arg Val Ile Ser Asp Ser Glu Ser Asp Ile Gly Gly Ser Asp Val           
        250                 255                 260                       

gaa ttt aag cca gac act aag gag gaa gga agc agt gat gaa ata agc        989
Glu Phe Lys Pro Asp Thr Lys Glu Glu Gly Ser Ser Asp Glu Ile Ser           
    265                 270                 275                           

agt gga gtg ggg gat agt gag agt gaa ggc ctg aac agc cct gtc aaa       1037
Ser Gly Val Gly Asp Ser Glu Ser Glu Gly Leu Asn Ser Pro Val Lys           
280                 285                 290                 295           

gtt gct cga aag cgg aag aga atg gtg act gga aat ggc tct ctt aaa       1085
Val Ala Arg Lys Arg Lys Arg Met Val Thr Gly Asn Gly Ser Leu Lys           
                300                 305                 310               

agg aaa agc tct agg aag gaa acg ccc tca gcc acc aaa caa gca act       1133
Arg Lys Ser Ser Arg Lys Glu Thr Pro Ser Ala Thr Lys Gln Ala Thr           
            315                 320                 325                   

agc att tca tca gaa acc aag aat act ttg aga gct ttc tct gcc cct       1181
Ser Ile Ser Ser Glu Thr Lys Asn Thr Leu Arg Ala Phe Ser Ala Pro           
        330                 335                 340                       

caa aat tct gaa tcc caa gcc cac gtt agt gga ggt ggt gat gac agt       1229
Gln Asn Ser Glu Ser Gln Ala His Val Ser Gly Gly Gly Asp Asp Ser           
    345                 350                 355                           

agt cgc cct act gtt tgg tat cat gaa act tta gaa tgg ctt aag gag       1277
Ser Arg Pro Thr Val Trp Tyr His Glu Thr Leu Glu Trp Leu Lys Glu           
360                 365                 370                 375           

gaa aag aga aga gat gag cac agg agg agg cct gat cac ccc gat ttt       1325
Glu Lys Arg Arg Asp Glu His Arg Arg Arg Pro Asp His Pro Asp Phe           
                380                 385                 390               

gat gca tct aca ctc tat gtg cct gag gat ttc ctc aat tct tgt act       1373
Asp Ala Ser Thr Leu Tyr Val Pro Glu Asp Phe Leu Asn Ser Cys Thr           
            395                 400                 405                   

cct ggg atg agg aag tgg tgg cag att aag tct cag aac ttt gat ctt       1421
Pro Gly Met Arg Lys Trp Trp Gln Ile Lys Ser Gln Asn Phe Asp Leu           
        410                 415                 420                       

gtc atc tgt tac aag gtg ggg aaa ttt tat gag ctg tac cac atg gat       1469
Val Ile Cys Tyr Lys Val Gly Lys Phe Tyr Glu Leu Tyr His Met Asp           
    425                 430                 435                           

gct ctt att gga gtc agt gaa ctg ggg ctg gta ttc atg aaa ggc aac       1517
Ala Leu Ile Gly Val Ser Glu Leu Gly Leu Val Phe Met Lys Gly Asn           
440                 445                 450                 455           

tgg gcc cat tct ggc ttt cct gaa att gca ttt ggc cgt tat tca gat       1565
Trp Ala His Ser Gly Phe Pro Glu Ile Ala Phe Gly Arg Tyr Ser Asp           
                460                 465                 470               

tcc ctg gtg cag aag ggc tat aaa gta gca cga gtg gaa cag act gag       1613
Ser Leu Val Gln Lys Gly Tyr Lys Val Ala Arg Val Glu Gln Thr Glu           
            475                 480                 485                   

act cca gaa atg atg gag gca cga tgt aga aag atg gca cat ata tcc       1661
Thr Pro Glu Met Met Glu Ala Arg Cys Arg Lys Met Ala His Ile Ser           
        490                 495                 500                       

aag tat gat aga gtg gtg agg agg gag atc tgt agg atc att acc aag       1709
Lys Tyr Asp Arg Val Val Arg Arg Glu Ile Cys Arg Ile Ile Thr Lys           
    505                 510                 515                           

ggt aca cag act tac agt gtg ctg gaa ggt gat ccc tct gag aac tac       1757
Gly Thr Gln Thr Tyr Ser Val Leu Glu Gly Asp Pro Ser Glu Asn Tyr           
520                 525                 530                 535           

agt aag tat ctt ctt agc ctc aaa gaa aaa gag gaa gat tct tct ggc       1805
Ser Lys Tyr Leu Leu Ser Leu Lys Glu Lys Glu Glu Asp Ser Ser Gly           
                540                 545                 550               

cat act cgt gca tat ggt gtg tgc ttt gtt gat act tca ctg gga aag       1853
His Thr Arg Ala Tyr Gly Val Cys Phe Val Asp Thr Ser Leu Gly Lys           
            555                 560                 565                   

ttt ttc ata ggt cag ttt tca gat gat cgc cat tgt tcg aga ttt agg       1901
Phe Phe Ile Gly Gln Phe Ser Asp Asp Arg His Cys Ser Arg Phe Arg           
        570                 575                 580                       

act cta gtg gca cac tat ccc cca gta caa gtt tta ttt gaa aaa gga       1949
Thr Leu Val Ala His Tyr Pro Pro Val Gln Val Leu Phe Glu Lys Gly           
    585                 590                 595                           

aat ctc tca aag gaa act aaa aca att cta aag agt tca ttg tcc tgt       1997
Asn Leu Ser Lys Glu Thr Lys Thr Ile Leu Lys Ser Ser Leu Ser Cys           
600                 605                 610                 615           

tct ctt cag gaa ggt ctg ata ccc ggc tcc cag ttt tgg gat gca tcc       2045
Ser Leu Gln Glu Gly Leu Ile Pro Gly Ser Gln Phe Trp Asp Ala Ser           
                620                 625                 630               

aaa act ttg aga act ctc ctt gag gaa gaa tat ttt agg gaa aag cta       2093
Lys Thr Leu Arg Thr Leu Leu Glu Glu Glu Tyr Phe Arg Glu Lys Leu           
            635                 640                 645                   

agt gat ggc att ggg gtg atg tta ccc cag gtg ctt aaa ggt atg act       2141
Ser Asp Gly Ile Gly Val Met Leu Pro Gln Val Leu Lys Gly Met Thr           
        650                 655                 660                       

tca gag tct gat tcc att ggg ttg aca cca gga gag aaa agt gaa ttg       2189
Ser Glu Ser Asp Ser Ile Gly Leu Thr Pro Gly Glu Lys Ser Glu Leu           
    665                 670                 675                           

gcc ctc tct gct cta ggt ggt tgt gtc ttc tac ctc aaa aaa tgc ctt       2237
Ala Leu Ser Ala Leu Gly Gly Cys Val Phe Tyr Leu Lys Lys Cys Leu           
680                 685                 690                 695           

att gat cag gag ctt tta tca atg gct aat ttt gaa gaa tat att ccc       2285
Ile Asp Gln Glu Leu Leu Ser Met Ala Asn Phe Glu Glu Tyr Ile Pro           
                700                 705                 710               

ttg gat tct gac aca gtc agc act aca aga tct ggt gct atc ttc acc       2333
Leu Asp Ser Asp Thr Val Ser Thr Thr Arg Ser Gly Ala Ile Phe Thr           
            715                 720                 725                   

aaa gcc tat caa cga atg gtg cta gat gca gtg aca tta aac aac ttg       2381
Lys Ala Tyr Gln Arg Met Val Leu Asp Ala Val Thr Leu Asn Asn Leu           
        730                 735                 740                       

gag att ttt ctg aat gga aca aat ggt tct act gaa gga acc cta cta       2429
Glu Ile Phe Leu Asn Gly Thr Asn Gly Ser Thr Glu Gly Thr Leu Leu           
    745                 750                 755                           

gag agg gtt gat act tgc cat act cct ttt ggt aag cgg ctc cta aag       2477
Glu Arg Val Asp Thr Cys His Thr Pro Phe Gly Lys Arg Leu Leu Lys           
760                 765                 770                 775           

caa tgg ctt tgt gcc cca ctc tgt aac cat tat gct att aat gat cgt       2525
Gln Trp Leu Cys Ala Pro Leu Cys Asn His Tyr Ala Ile Asn Asp Arg           
                780                 785                 790               

cta gat gcc ata gaa gac ctc atg gtt gtg cct gac aaa atc tcc gaa       2573
Leu Asp Ala Ile Glu Asp Leu Met Val Val Pro Asp Lys Ile Ser Glu           
            795                 800                 805                   

gtt gta gag ctt cta aag aag ctt cca gat ctt gag agg cta ctc agt       2621
Val Val Glu Leu Leu Lys Lys Leu Pro Asp Leu Glu Arg Leu Leu Ser           
        810                 815                 820                       

aaa att cat aat gtt ggg tct ccc ctg aag agt cag aac cac cca gac       2669
Lys Ile His Asn Val Gly Ser Pro Leu Lys Ser Gln Asn His Pro Asp           
    825                 830                 835                           

agc agg gct ata atg tat gaa gaa act aca tac agc aag aag aag att       2717
Ser Arg Ala Ile Met Tyr Glu Glu Thr Thr Tyr Ser Lys Lys Lys Ile           
840                 845                 850                 855           

att gat ttt ctt tct gct ctg gaa gga ttc aaa gta atg tgt aaa att       2765
Ile Asp Phe Leu Ser Ala Leu Glu Gly Phe Lys Val Met Cys Lys Ile           
                860                 865                 870               

ata ggg atc atg gaa gaa gtt gct gat ggt ttt aag tct aaa atc ctt       2813
Ile Gly Ile Met Glu Glu Val Ala Asp Gly Phe Lys Ser Lys Ile Leu           
            875                 880                 885                   

aag cag gtc atc tct ctg cag aca aaa aat cct gaa ggt cgt ttt cct       2861
Lys Gln Val Ile Ser Leu Gln Thr Lys Asn Pro Glu Gly Arg Phe Pro           
        890                 895                 900                       

gat ttg act gta gaa ttg aac cga tgg gat aca gcc ttt gac cat gaa       2909
Asp Leu Thr Val Glu Leu Asn Arg Trp Asp Thr Ala Phe Asp His Glu           
    905                 910                 915                           

aag gct cga aag act gga ctt att act ccc aaa gca ggc ttt gac tct       2957
Lys Ala Arg Lys Thr Gly Leu Ile Thr Pro Lys Ala Gly Phe Asp Ser           
920                 925                 930                 935           

gat tat gac caa gct ctt gct gac ata aga gaa aat gaa cag agc ctc       3005
Asp Tyr Asp Gln Ala Leu Ala Asp Ile Arg Glu Asn Glu Gln Ser Leu           
                940                 945                 950               

ctg gaa tac cta gag aaa cag cgc aac aga att ggc tgt agg acc ata       3053
Leu Glu Tyr Leu Glu Lys Gln Arg Asn Arg Ile Gly Cys Arg Thr Ile           
            955                 960                 965                   

gtc tat tgg ggg att ggt agg aac cgt tac cag ctg gaa att cct gag       3101
Val Tyr Trp Gly Ile Gly Arg Asn Arg Tyr Gln Leu Glu Ile Pro Glu           
        970                 975                 980                       

aat ttc acc act cgc aat ttg cca gaa gaa tac gag ttg aaa tct acc       3149
Asn Phe Thr Thr Arg Asn Leu Pro Glu Glu Tyr Glu Leu Lys Ser Thr           
    985                 990                 995                           

aag  aag ggc tgt aaa cga  tac tgg acc aaa act  att gaa aag aag        3194
Lys  Lys Gly Cys Lys Arg  Tyr Trp Thr Lys Thr  Ile Glu Lys Lys            
1000                 1005                 1010                            

ttg  gct aat ctc ata aat  gct gaa gaa cgg agg  gat gta tca ttg        3239
Leu  Ala Asn Leu Ile Asn  Ala Glu Glu Arg Arg  Asp Val Ser Leu            
1015                 1020                 1025                            

aag  gac tgc atg cgg cga  ctg ttc tat aac ttt  gat aaa aat tac        3284
Lys  Asp Cys Met Arg Arg  Leu Phe Tyr Asn Phe  Asp Lys Asn Tyr            
1030                 1035                 1040                            

aag  gac tgg cag tct gct  gta gag tgt atc gca  gtg ttg gat gtt        3329
Lys  Asp Trp Gln Ser Ala  Val Glu Cys Ile Ala  Val Leu Asp Val            
1045                 1050                 1055                            

tta  ctg tgc ctg gct aac  tat agt cga ggg ggt  gat ggt cct atg        3374
Leu  Leu Cys Leu Ala Asn  Tyr Ser Arg Gly Gly  Asp Gly Pro Met            
1060                 1065                 1070                            

tgt  cgc cca gta att ctg  ttg ccg gaa gat acc  ccc ccc ttc tta        3419
Cys  Arg Pro Val Ile Leu  Leu Pro Glu Asp Thr  Pro Pro Phe Leu            
1075                 1080                 1085                            

gag  ctt aaa gga tca cgc  cat cct tgc att acg  aag act ttt ttt        3464
Glu  Leu Lys Gly Ser Arg  His Pro Cys Ile Thr  Lys Thr Phe Phe            
1090                 1095                 1100                            

gga  gat gat ttt att cct  aat gac att cta ata  ggc tgt gag gaa        3509
Gly  Asp Asp Phe Ile Pro  Asn Asp Ile Leu Ile  Gly Cys Glu Glu            
1105                 1110                 1115                            

gag  gag cag gaa aat ggc  aaa gcc tat tgt gtg  ctt gtt act gga        3554
Glu  Glu Gln Glu Asn Gly  Lys Ala Tyr Cys Val  Leu Val Thr Gly            
1120                 1125                 1130                            

cca  aat atg ggg ggc aag  tct acg ctt atg aga  cag gct ggc tta        3599
Pro  Asn Met Gly Gly Lys  Ser Thr Leu Met Arg  Gln Ala Gly Leu            
1135                 1140                 1145                            

tta  gct gta atg gcc cag  atg ggt tgt tac gtc  cct gct gaa gtg        3644
Leu  Ala Val Met Ala Gln  Met Gly Cys Tyr Val  Pro Ala Glu Val            
1150                 1155                 1160                            

tgc  agg ctc aca cca att  gat aga gtg ttt act  aga ctt ggt gcc        3689
Cys  Arg Leu Thr Pro Ile  Asp Arg Val Phe Thr  Arg Leu Gly Ala            
1165                 1170                 1175                            

tca  gac aga ata atg tca  ggt gaa agt aca ttt  ttt gtt gaa tta        3734
Ser  Asp Arg Ile Met Ser  Gly Glu Ser Thr Phe  Phe Val Glu Leu            
1180                 1185                 1190                            

agt  gaa act gcc agc ata  ctc atg cat gca aca  gca cat tct ctg        3779
Ser  Glu Thr Ala Ser Ile  Leu Met His Ala Thr  Ala His Ser Leu            
1195                 1200                 1205                            

gtg  ctt gtg gat gaa tta  gga aga ggt act gca  aca ttt gat ggg        3824
Val  Leu Val Asp Glu Leu  Gly Arg Gly Thr Ala  Thr Phe Asp Gly            
1210                 1215                 1220                            

acg  gca ata gca aat gca  gtt gtt aaa gaa ctt  gct gag act ata        3869
Thr  Ala Ile Ala Asn Ala  Val Val Lys Glu Leu  Ala Glu Thr Ile            
1225                 1230                 1235                            

aaa  tgt cgt aca tta ttt  tca act cac tac cat  tca tta gta gaa        3914
Lys  Cys Arg Thr Leu Phe  Ser Thr His Tyr His  Ser Leu Val Glu            
1240                 1245                 1250                            

gat  tat tct caa aat gtt  gct gtg cgc cta gga  cat atg gca tgc        3959
Asp  Tyr Ser Gln Asn Val  Ala Val Arg Leu Gly  His Met Ala Cys            
1255                 1260                 1265                            

atg  gta gaa aat gaa tgt  gaa gac ccc agc cag  gag act att acg        4004
Met  Val Glu Asn Glu Cys  Glu Asp Pro Ser Gln  Glu Thr Ile Thr            
1270                 1275                 1280                            

ttc  ctc tat aaa ttc att  aag gga gct tgt cct  aaa agc tat ggc        4049
Phe  Leu Tyr Lys Phe Ile  Lys Gly Ala Cys Pro  Lys Ser Tyr Gly            
1285                 1290                 1295                            

ttt  aat gca gca agg ctt  gct aat ctc cca gag  gaa gtt att caa        4094
Phe  Asn Ala Ala Arg Leu  Ala Asn Leu Pro Glu  Glu Val Ile Gln            
1300                 1305                 1310                            

aag  gga cat aga aaa gca  aga gaa ttt gag aag  atg aat cag tca        4139
Lys  Gly His Arg Lys Ala  Arg Glu Phe Glu Lys  Met Asn Gln Ser            
1315                 1320                 1325                            

cta  cga tta ttt cgg gaa  gtt tgc ctg gct agt  gaa agg tca act        4184
Leu  Arg Leu Phe Arg Glu  Val Cys Leu Ala Ser  Glu Arg Ser Thr            
1330                 1335                 1340                            

gta  gat gct gaa gct gtc  cat aaa ttg ctg act  ttg att aag gaa        4229
Val  Asp Ala Glu Ala Val  His Lys Leu Leu Thr  Leu Ile Lys Glu            
1345                 1350                 1355                            

tta  tag actgactaca ttggaagctt tgagttgact tctgacaaag gtggtaaatt       4285
Leu                                                                       
1360                                                                      

cagacaacat tatgatctaa taaactttat tttttaaaaa tgaaaaaaaa aaaaaaaaaa     4345

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4405

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      4435


<210>  538
<211>  1360
<212>  PRT
<213>  Homo sapiens

<400>  538

Met Ser Arg Gln Ser Thr Leu Tyr Ser Phe Phe Pro Lys Ser Pro Ala 
1               5                   10                  15      


Leu Ser Asp Ala Asn Lys Ala Ser Ala Arg Ala Ser Arg Glu Gly Gly 
            20                  25                  30          


Arg Ala Ala Ala Ala Pro Gly Ala Ser Pro Ser Pro Gly Gly Asp Ala 
        35                  40                  45              


Ala Trp Ser Glu Ala Gly Pro Gly Pro Arg Pro Leu Ala Arg Ser Ala 
    50                  55                  60                  


Ser Pro Pro Lys Ala Lys Asn Leu Asn Gly Gly Leu Arg Arg Ser Val 
65                  70                  75                  80  


Ala Pro Ala Ala Pro Thr Ser Cys Asp Phe Ser Pro Gly Asp Leu Val 
                85                  90                  95      


Trp Ala Lys Met Glu Gly Tyr Pro Trp Trp Pro Cys Leu Val Tyr Asn 
            100                 105                 110         


His Pro Phe Asp Gly Thr Phe Ile Arg Glu Lys Gly Lys Ser Val Arg 
        115                 120                 125             


Val His Val Gln Phe Phe Asp Asp Ser Pro Thr Arg Gly Trp Val Ser 
    130                 135                 140                 


Lys Arg Leu Leu Lys Pro Tyr Thr Gly Ser Lys Ser Lys Glu Ala Gln 
145                 150                 155                 160 


Lys Gly Gly His Phe Tyr Ser Ala Lys Pro Glu Ile Leu Arg Ala Met 
                165                 170                 175     


Gln Arg Ala Asp Glu Ala Leu Asn Lys Asp Lys Ile Lys Arg Leu Glu 
            180                 185                 190         


Leu Ala Val Cys Asp Glu Pro Ser Glu Pro Glu Glu Glu Glu Glu Met 
        195                 200                 205             


Glu Val Gly Thr Thr Tyr Val Thr Asp Lys Ser Glu Glu Asp Asn Glu 
    210                 215                 220                 


Ile Glu Ser Glu Glu Glu Val Gln Pro Lys Thr Gln Gly Ser Arg Arg 
225                 230                 235                 240 


Ser Ser Arg Gln Ile Lys Lys Arg Arg Val Ile Ser Asp Ser Glu Ser 
                245                 250                 255     


Asp Ile Gly Gly Ser Asp Val Glu Phe Lys Pro Asp Thr Lys Glu Glu 
            260                 265                 270         


Gly Ser Ser Asp Glu Ile Ser Ser Gly Val Gly Asp Ser Glu Ser Glu 
        275                 280                 285             


Gly Leu Asn Ser Pro Val Lys Val Ala Arg Lys Arg Lys Arg Met Val 
    290                 295                 300                 


Thr Gly Asn Gly Ser Leu Lys Arg Lys Ser Ser Arg Lys Glu Thr Pro 
305                 310                 315                 320 


Ser Ala Thr Lys Gln Ala Thr Ser Ile Ser Ser Glu Thr Lys Asn Thr 
                325                 330                 335     


Leu Arg Ala Phe Ser Ala Pro Gln Asn Ser Glu Ser Gln Ala His Val 
            340                 345                 350         


Ser Gly Gly Gly Asp Asp Ser Ser Arg Pro Thr Val Trp Tyr His Glu 
        355                 360                 365             


Thr Leu Glu Trp Leu Lys Glu Glu Lys Arg Arg Asp Glu His Arg Arg 
    370                 375                 380                 


Arg Pro Asp His Pro Asp Phe Asp Ala Ser Thr Leu Tyr Val Pro Glu 
385                 390                 395                 400 


Asp Phe Leu Asn Ser Cys Thr Pro Gly Met Arg Lys Trp Trp Gln Ile 
                405                 410                 415     


Lys Ser Gln Asn Phe Asp Leu Val Ile Cys Tyr Lys Val Gly Lys Phe 
            420                 425                 430         


Tyr Glu Leu Tyr His Met Asp Ala Leu Ile Gly Val Ser Glu Leu Gly 
        435                 440                 445             


Leu Val Phe Met Lys Gly Asn Trp Ala His Ser Gly Phe Pro Glu Ile 
    450                 455                 460                 


Ala Phe Gly Arg Tyr Ser Asp Ser Leu Val Gln Lys Gly Tyr Lys Val 
465                 470                 475                 480 


Ala Arg Val Glu Gln Thr Glu Thr Pro Glu Met Met Glu Ala Arg Cys 
                485                 490                 495     


Arg Lys Met Ala His Ile Ser Lys Tyr Asp Arg Val Val Arg Arg Glu 
            500                 505                 510         


Ile Cys Arg Ile Ile Thr Lys Gly Thr Gln Thr Tyr Ser Val Leu Glu 
        515                 520                 525             


Gly Asp Pro Ser Glu Asn Tyr Ser Lys Tyr Leu Leu Ser Leu Lys Glu 
    530                 535                 540                 


Lys Glu Glu Asp Ser Ser Gly His Thr Arg Ala Tyr Gly Val Cys Phe 
545                 550                 555                 560 


Val Asp Thr Ser Leu Gly Lys Phe Phe Ile Gly Gln Phe Ser Asp Asp 
                565                 570                 575     


Arg His Cys Ser Arg Phe Arg Thr Leu Val Ala His Tyr Pro Pro Val 
            580                 585                 590         


Gln Val Leu Phe Glu Lys Gly Asn Leu Ser Lys Glu Thr Lys Thr Ile 
        595                 600                 605             


Leu Lys Ser Ser Leu Ser Cys Ser Leu Gln Glu Gly Leu Ile Pro Gly 
    610                 615                 620                 


Ser Gln Phe Trp Asp Ala Ser Lys Thr Leu Arg Thr Leu Leu Glu Glu 
625                 630                 635                 640 


Glu Tyr Phe Arg Glu Lys Leu Ser Asp Gly Ile Gly Val Met Leu Pro 
                645                 650                 655     


Gln Val Leu Lys Gly Met Thr Ser Glu Ser Asp Ser Ile Gly Leu Thr 
            660                 665                 670         


Pro Gly Glu Lys Ser Glu Leu Ala Leu Ser Ala Leu Gly Gly Cys Val 
        675                 680                 685             


Phe Tyr Leu Lys Lys Cys Leu Ile Asp Gln Glu Leu Leu Ser Met Ala 
    690                 695                 700                 


Asn Phe Glu Glu Tyr Ile Pro Leu Asp Ser Asp Thr Val Ser Thr Thr 
705                 710                 715                 720 


Arg Ser Gly Ala Ile Phe Thr Lys Ala Tyr Gln Arg Met Val Leu Asp 
                725                 730                 735     


Ala Val Thr Leu Asn Asn Leu Glu Ile Phe Leu Asn Gly Thr Asn Gly 
            740                 745                 750         


Ser Thr Glu Gly Thr Leu Leu Glu Arg Val Asp Thr Cys His Thr Pro 
        755                 760                 765             


Phe Gly Lys Arg Leu Leu Lys Gln Trp Leu Cys Ala Pro Leu Cys Asn 
    770                 775                 780                 


His Tyr Ala Ile Asn Asp Arg Leu Asp Ala Ile Glu Asp Leu Met Val 
785                 790                 795                 800 


Val Pro Asp Lys Ile Ser Glu Val Val Glu Leu Leu Lys Lys Leu Pro 
                805                 810                 815     


Asp Leu Glu Arg Leu Leu Ser Lys Ile His Asn Val Gly Ser Pro Leu 
            820                 825                 830         


Lys Ser Gln Asn His Pro Asp Ser Arg Ala Ile Met Tyr Glu Glu Thr 
        835                 840                 845             


Thr Tyr Ser Lys Lys Lys Ile Ile Asp Phe Leu Ser Ala Leu Glu Gly 
    850                 855                 860                 


Phe Lys Val Met Cys Lys Ile Ile Gly Ile Met Glu Glu Val Ala Asp 
865                 870                 875                 880 


Gly Phe Lys Ser Lys Ile Leu Lys Gln Val Ile Ser Leu Gln Thr Lys 
                885                 890                 895     


Asn Pro Glu Gly Arg Phe Pro Asp Leu Thr Val Glu Leu Asn Arg Trp 
            900                 905                 910         


Asp Thr Ala Phe Asp His Glu Lys Ala Arg Lys Thr Gly Leu Ile Thr 
        915                 920                 925             


Pro Lys Ala Gly Phe Asp Ser Asp Tyr Asp Gln Ala Leu Ala Asp Ile 
    930                 935                 940                 


Arg Glu Asn Glu Gln Ser Leu Leu Glu Tyr Leu Glu Lys Gln Arg Asn 
945                 950                 955                 960 


Arg Ile Gly Cys Arg Thr Ile Val Tyr Trp Gly Ile Gly Arg Asn Arg 
                965                 970                 975     


Tyr Gln Leu Glu Ile Pro Glu Asn Phe Thr Thr Arg Asn Leu Pro Glu 
            980                 985                 990         


Glu Tyr Glu Leu Lys Ser Thr Lys  Lys Gly Cys Lys Arg  Tyr Trp Thr 
        995                 1000                 1005             


Lys Thr  Ile Glu Lys Lys Leu  Ala Asn Leu Ile Asn  Ala Glu Glu 
    1010                 1015                 1020             


Arg Arg  Asp Val Ser Leu Lys  Asp Cys Met Arg Arg  Leu Phe Tyr 
    1025                 1030                 1035             


Asn Phe  Asp Lys Asn Tyr Lys  Asp Trp Gln Ser Ala  Val Glu Cys 
    1040                 1045                 1050             


Ile Ala  Val Leu Asp Val Leu  Leu Cys Leu Ala Asn  Tyr Ser Arg 
    1055                 1060                 1065             


Gly Gly  Asp Gly Pro Met Cys  Arg Pro Val Ile Leu  Leu Pro Glu 
    1070                 1075                 1080             


Asp Thr  Pro Pro Phe Leu Glu  Leu Lys Gly Ser Arg  His Pro Cys 
    1085                 1090                 1095             


Ile Thr  Lys Thr Phe Phe Gly  Asp Asp Phe Ile Pro  Asn Asp Ile 
    1100                 1105                 1110             


Leu Ile  Gly Cys Glu Glu Glu  Glu Gln Glu Asn Gly  Lys Ala Tyr 
    1115                 1120                 1125             


Cys Val  Leu Val Thr Gly Pro  Asn Met Gly Gly Lys  Ser Thr Leu 
    1130                 1135                 1140             


Met Arg  Gln Ala Gly Leu Leu  Ala Val Met Ala Gln  Met Gly Cys 
    1145                 1150                 1155             


Tyr Val  Pro Ala Glu Val Cys  Arg Leu Thr Pro Ile  Asp Arg Val 
    1160                 1165                 1170             


Phe Thr  Arg Leu Gly Ala Ser  Asp Arg Ile Met Ser  Gly Glu Ser 
    1175                 1180                 1185             


Thr Phe  Phe Val Glu Leu Ser  Glu Thr Ala Ser Ile  Leu Met His 
    1190                 1195                 1200             


Ala Thr  Ala His Ser Leu Val  Leu Val Asp Glu Leu  Gly Arg Gly 
    1205                 1210                 1215             


Thr Ala  Thr Phe Asp Gly Thr  Ala Ile Ala Asn Ala  Val Val Lys 
    1220                 1225                 1230             


Glu Leu  Ala Glu Thr Ile Lys  Cys Arg Thr Leu Phe  Ser Thr His 
    1235                 1240                 1245             


Tyr His  Ser Leu Val Glu Asp  Tyr Ser Gln Asn Val  Ala Val Arg 
    1250                 1255                 1260             


Leu Gly  His Met Ala Cys Met  Val Glu Asn Glu Cys  Glu Asp Pro 
    1265                 1270                 1275             


Ser Gln  Glu Thr Ile Thr Phe  Leu Tyr Lys Phe Ile  Lys Gly Ala 
    1280                 1285                 1290             


Cys Pro  Lys Ser Tyr Gly Phe  Asn Ala Ala Arg Leu  Ala Asn Leu 
    1295                 1300                 1305             


Pro Glu  Glu Val Ile Gln Lys  Gly His Arg Lys Ala  Arg Glu Phe 
    1310                 1315                 1320             


Glu Lys  Met Asn Gln Ser Leu  Arg Leu Phe Arg Glu  Val Cys Leu 
    1325                 1330                 1335             


Ala Ser  Glu Arg Ser Thr Val  Asp Ala Glu Ala Val  His Lys Leu 
    1340                 1345                 1350             


Leu Thr  Leu Ile Lys Glu Leu  
    1355                 1360 


<210>  539
<211>  5046
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (109)..(3882)

<400>  539
tgcccccact cccaactccc gccccaagcc gcccaccagc ccccttcccc tccggccgga       60

gcctgaaccg agcccggctg gctgtgctgc gcggtgccgc cgggaaag atg gtc gtg       117
                                                     Met Val Val          
                                                     1                    

gcg ctg cgg tac gtg tgg cct ctc ctc ctc tgc agc ccc tgc ctg ctt        165
Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro Cys Leu Leu           
    5                   10                  15                            

atc cag atc ccc gag gaa tat gaa gga cac cat gtg atg gag cca cct        213
Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met Glu Pro Pro           
20                  25                  30                  35            

gtc atc acg gaa cag tct cca cgg cgc ctg gtt gtc ttc ccc aca gat        261
Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe Pro Thr Asp           
                40                  45                  50                

gac atc agc ctc aag tgt gag gcc agt ggc aag ccc gaa gtg cag ttc        309
Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu Val Gln Phe           
            55                  60                  65                    

cgc tgg acg agg gat ggt gtc cac ttc aaa ccc aag gaa gag ctg ggt        357
Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu Glu Leu Gly           
        70                  75                  80                        

gtg acc gtg tac cag tcg ccc cac tct ggc tcc ttc acc atc acg ggc        405
Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr Ile Thr Gly           
    85                  90                  95                            

aac aac agc aac ttt gct cag agg ttc cag ggc atc tac cgc tgc ttt        453
Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr Arg Cys Phe           
100                 105                 110                 115           

gcc agc aat aag ctg ggc acc gcc atg tcc cat gag atc cgg ctc atg        501
Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile Arg Leu Met           
                120                 125                 130               

gcc gag ggt gcc ccc aag tgg cca aag gag aca gtg aag ccc gtg gag        549
Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys Pro Val Glu           
            135                 140                 145                   

gtg gag gaa ggg gag tca gtg gtt ctg cct tgc aac cct ccc cca agt        597
Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro Pro Pro Ser           
        150                 155                 160                       

gca gag cct ctc cgg atc tac tgg atg aac agc aag atc ttg cac atc        645
Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile Leu His Ile           
    165                 170                 175                           

aag cag gac gag cgg gtg acg atg ggc cag aac ggc aac ctc tac ttt        693
Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn Leu Tyr Phe           
180                 185                 190                 195           

gcc aat gtg ctc acc tcc gac aac cac tca gac tac atc tgc cac gcc        741
Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile Cys His Ala           
                200                 205                 210               

cac ttc cca ggc acc agg acc atc att cag aag gaa ccc att gac ctc        789
His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro Ile Asp Leu           
            215                 220                 225                   

cgg gtc aag gcc acc aac agc atg att gac agg aag ccg cgc ctg ctc        837
Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro Arg Leu Leu           
        230                 235                 240                       

ttc ccc acc aac tcc agc agc cac ctg gtg gcc ttg cag ggg cag cca        885
Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln Gly Gln Pro           
    245                 250                 255                           

ttg gtc ctg gag tgc atc gcc gag ggc ttt ccc acg ccc acc atc aaa        933
Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro Thr Ile Lys           
260                 265                 270                 275           

tgg ctg cgc ccc agt ggc ccc atg cca gcc gac cgt gtc acc tac cag        981
Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val Thr Tyr Gln           
                280                 285                 290               

aac cac aac aag acc ctg cag ctg ctg aaa gtg ggc gag gag gat gat       1029
Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu Glu Asp Asp           
            295                 300                 305                   

ggc gag tac cgc tgc ctg gcc gag aac tca ctg ggc agt gcc cgg cat       1077
Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser Ala Arg His           
        310                 315                 320                       

gcg tac tat gtc acc gtg gag gct gcc ccg tac tgg ctg cac aag ccc       1125
Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu His Lys Pro           
    325                 330                 335                           

cag agc cat cta tat ggg cca gga gag act gcc cgc ctg gac tgc caa       1173
Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu Asp Cys Gln           
340                 345                 350                 355           

gtc cag ggc agg ccc caa cca gag gtc acc tgg aga atc aac ggg atc       1221
Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile Asn Gly Ile           
                360                 365                 370               

cct gtg gag gag ctg gcc aaa gac cag aag tac cgg att cag cgt ggc       1269
Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile Gln Arg Gly           
            375                 380                 385                   

gcc ctg atc ctg agc aac gtg cag ccc agt gac aca atg gtg acc caa       1317
Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met Val Thr Gln           
        390                 395                 400                       

tgt gag gcc cgc aac cgg cac ggg ctc ttg ctg gcc aat gcc tac atc       1365
Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn Ala Tyr Ile           
    405                 410                 415                           

tac gtt gtc cag ctg cca gcc aag atc ctg act gcg gac aat cag acg       1413
Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp Asn Gln Thr           
420                 425                 430                 435           

tac atg gct gtc cag ggc agc act gcc tac ctt ctg tgc aag gcc ttc       1461
Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys Lys Ala Phe           
                440                 445                 450               

gga gcg cct gtg ccc agt gtt cag tgg ctg gac gag gat ggg aca aca       1509
Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp Gly Thr Thr           
            455                 460                 465                   

gtg ctt cag gac gaa cgc ttc ttc ccc tat gcc aat ggg acc ctg ggc       1557
Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly Thr Leu Gly           
        470                 475                 480                       

att cga gac ctc cag gcc aat gac acc gga cgc tac ttc tgc ctg gct       1605
Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe Cys Leu Ala           
    485                 490                 495                           

gcc aat gac caa aac aat gtt acc atc atg gct aac ctg aag gtt aaa       1653
Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu Lys Val Lys           
500                 505                 510                 515           

gat gca act cag atc act cag ggg ccc cgc agc aca atc gag aag aaa       1701
Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile Glu Lys Lys           
                520                 525                 530               

ggt tcc agg gtg acc ttc acg tgc cag gcc tcc ttt gac ccc tcc ttg       1749
Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp Pro Ser Leu           
            535                 540                 545                   

cag ccc agc atc acc tgg cgt ggg gac ggt cga gac ctc cag gag ctt       1797
Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu Gln Glu Leu           
        550                 555                 560                       

ggg gac agt gac aag tac ttc ata gag gat ggg cgc ctg gtc atc cac       1845
Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu Val Ile His           
    565                 570                 575                           

agc ctg gac tac agc gac cag ggc aac tac agc tgc gtg gcc agt acc       1893
Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val Ala Ser Thr           
580                 585                 590                 595           

gaa ctg gat gtg gtg gag agt agg gca cag ctc ttg gtg gtg ggg agc       1941
Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val Val Gly Ser           
                600                 605                 610               

cct ggg ccg gtg cca cgg ctg gtg ctg tcc gac ctg cac ctg ctg acg       1989
Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His Leu Leu Thr           
            615                 620                 625                   

cag agc cag gtg cgc gtg tcc tgg agt cct gca gaa gac cac aat gcc       2037
Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp His Asn Ala           
        630                 635                 640                       

ccc att gag aaa tat gac att gaa ttt gag gac aag gaa atg gcg cct       2085
Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu Met Ala Pro           
    645                 650                 655                           

gaa aaa tgg tac agt ctg ggc aag gtt cca ggg aac cag acc tct acc       2133
Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln Thr Ser Thr           
660                 665                 670                 675           

acc ctc aag ctg tcg ccc tat gtc cac tac acc ttt agg gtt act gcc       2181
Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg Val Thr Ala           
                680                 685                 690               

ata aac aaa tat ggc ccc ggg gag ccc agc ccg gtc tct gag act gtg       2229
Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser Glu Thr Val           
            695                 700                 705                   

gtc aca cct gag gca gcc cca gag aag aac cct gtg gat gtg aag ggg       2277
Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp Val Lys Gly           
        710                 715                 720                       

gaa gga aat gag acc acc aat atg gtc atc acg tgg aag ccg ctc cgg       2325
Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys Pro Leu Arg           
    725                 730                 735                           

tgg atg gac tgg aac gcc ccc cag gtt cag tac cgc gtg cag tgg cgc       2373
Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val Gln Trp Arg           
740                 745                 750                 755           

cct cag ggg aca cga ggg ccc tgg cag gag cag att gtc agc gac ccc       2421
Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val Ser Asp Pro           
                760                 765                 770               

ttc ctg gtg gtg tcc aac acg tcc acc ttc gtg ccc tat gag atc aaa       2469
Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr Glu Ile Lys           
            775                 780                 785                   

gtc cag gcc gtc aac agc cag ggc aag gga cca gag ccc cag gtc act       2517
Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro Gln Val Thr           
        790                 795                 800                       

atc ggc tac tct gga gag gac tac ccc cag gca atc cct gag ctg gaa       2565
Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro Glu Leu Glu           
    805                 810                 815                           

ggc att gaa atc ctc aac tca agt gcc gtg ctg gtc aag tgg cgg ccg       2613
Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys Trp Arg Pro           
820                 825                 830                 835           

gtg gac ctg gcc cag gtc aag ggc cac ctc cgc gga tac aat gtg acg       2661
Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr Asn Val Thr           
                840                 845                 850               

tac tgg agg gag ggc agt cag agg aag cac agc aag aga cat atc cac       2709
Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg His Ile His           
            855                 860                 865                   

aaa gac cat gtg gtg gtg ccc gcc aac acc acc agt gtc atc ctc agt       2757
Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val Ile Leu Ser           
        870                 875                 880                       

ggc ttg cgg ccc tat agc tcc tac cac ctg gag gtg cag gcc ttt aac       2805
Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln Ala Phe Asn           
    885                 890                 895                           

ggg cga gga tcg ggg ccc gcc agc gag ttc acc ttc agc acc cca gag       2853
Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser Thr Pro Glu           
900                 905                 910                 915           

gga gtg cct ggc cac ccc gag gcg ttg cac ctg gag tgc cag tcg aac       2901
Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys Gln Ser Asn           
                920                 925                 930               

acc agc ctg ctg ctg cgc tgg cag ccc cca ctc agc cac aac ggc gtg       2949
Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His Asn Gly Val           
            935                 940                 945                   

ctc acc ggc tac gtg ctc tcc tac cac ccc ctg gat gag ggg ggc aag       2997
Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu Gly Gly Lys           
        950                 955                 960                       

ggg caa ctg tcc ttc aac ctt cgg gac ccc gaa ctt cgg aca cac aac       3045
Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg Thr His Asn           
    965                 970                 975                           

ctg acc gat ctc agc ccc cac ctg cgg tac cgc ttc cag ctt cag gcc       3093
Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln Leu Gln Ala           
980                 985                 990                 995           

acc acc aaa gag ggc  cct ggt gaa gcc atc  gta cgg gaa gga ggc         3138
Thr Thr Lys Glu Gly  Pro Gly Glu Ala Ile  Val Arg Glu Gly Gly             
                1000                 1005                 1010            

act atg gcc ttg tct  ggg atc tca gat ttt  ggc aac atc tca gcc         3183
Thr Met Ala Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile Ser Ala             
                1015                 1020                 1025            

aca gcg ggt gaa aac  tac agt gtc gtc tcc  tgg gtc ccc aag gag         3228
Thr Ala Gly Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro Lys Glu             
                1030                 1035                 1040            

ggc cag tgc aac ttc  agg ttc cat atc ttg  ttc aaa gcc ttg gga         3273
Gly Gln Cys Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala Leu Gly             
                1045                 1050                 1055            

gaa gag aag ggt ggg  gct tcc ctt tcg cca  cag tat gtc agc tac         3318
Glu Glu Lys Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val Ser Tyr             
                1060                 1065                 1070            

aac cag agc tcc tac  acg cag tgg gac ctg  cag cct gac act gac         3363
Asn Gln Ser Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp Thr Asp             
                1075                 1080                 1085            

tac gag atc cac ttg  ttt aag gag agg atg  ttc cgg cac caa atg         3408
Tyr Glu Ile His Leu  Phe Lys Glu Arg Met  Phe Arg His Gln Met             
                1090                 1095                 1100            

gct gtg aag acc aat  ggc aca ggc cgc gtg  agg ctc cct cct gct         3453
Ala Val Lys Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro Pro Ala             
                1105                 1110                 1115            

ggc ttc gcc act gag  ggc tgg ttc atc ggc  ttt gtg agt gcc atc         3498
Gly Phe Ala Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser Ala Ile             
                1120                 1125                 1130            

atc ctc ctg ctc ctc  gtc ctg ctc atc ctc  tgc ttc atc aag cgc         3543
Ile Leu Leu Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile Lys Arg             
                1135                 1140                 1145            

agc aag ggc ggc aaa  tac tca gtg aag gat  aag gag gac acc cag         3588
Ser Lys Gly Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp Thr Gln             
                1150                 1155                 1160            

gtg gac tct gag gcc  cga ccg atg aaa gat  gag acc ttc ggc gag         3633
Val Asp Ser Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe Gly Glu             
                1165                 1170                 1175            

tac agg tcc ctg gag  agt gac aac gag gag  aag gcc ttt ggc agc         3678
Tyr Arg Ser Leu Glu  Ser Asp Asn Glu Glu  Lys Ala Phe Gly Ser             
                1180                 1185                 1190            

agc cag cca tcg ctc  aac ggg gac atc aag  ccc ctg ggc agt gac         3723
Ser Gln Pro Ser Leu  Asn Gly Asp Ile Lys  Pro Leu Gly Ser Asp             
                1195                 1200                 1205            

gac agc ctg gcc gat  tat ggg ggc agc gtg  gat gtt cag ttc aac         3768
Asp Ser Leu Ala Asp  Tyr Gly Gly Ser Val  Asp Val Gln Phe Asn             
                1210                 1215                 1220            

gag gat ggt tcg ttc  att ggc cag tac agt  ggc aag aag gag aag         3813
Glu Asp Gly Ser Phe  Ile Gly Gln Tyr Ser  Gly Lys Lys Glu Lys             
                1225                 1230                 1235            

gag gcg gca ggg ggc  aat gac agc tca ggg  gcc act tcc ccc atc         3858
Glu Ala Ala Gly Gly  Asn Asp Ser Ser Gly  Ala Thr Ser Pro Ile             
                1240                 1245                 1250            

aac cct gcc gtg gcc  cta gaa tag tggagtccag gacaggagat gctgtgcccc     3912
Asn Pro Ala Val Ala  Leu Glu                                              
                1255                                                      

tggccttggg atccaggccc ctccctctcc agcaggccca tgggaggctg gagttggggc     3972

agaggagaac ttgctgcctc ggatcccctt cctaccaccc ggtccccact ttattgccaa     4032

aacccagctg caccccttcc tgggcacacg ctgctctgcc ccagcttggg cagatctccc     4092

acatgccagg ggcctttggg tgctgttttg ccagcccatt tgggcagaga ggctgtggtt     4152

tgggggagaa gaagtagggg tggcccgaaa gggtctccga aatgctgtct ttcttgctcc     4212

ctgactgggg gcagacatgg tggggtctcc tcaggaccag ggttggcacc ttccccctcc     4272

cccagccact ccccagccag cctggctggg actgggaaca gaactcggtg tccccaccat     4332

ctgctgtctt ttctttgcca tctctgctcc aaccgggatg ggagccgggc aaactggccg     4392

cgggggcagg ggaggccatc tggagagccc agagtccccc cactcccagc atcgcactct     4452

ggcagcaccg cctcttcccg ccgcccagcc caccccatgg ccggctttca ggagctccat     4512

acacacgctg ccttcggtac ccaccacaca acatccaagt ggcctccgtc actacctggc     4572

tgcggggcgg gcacacctcc tcccactgcc cactggccgg cctcttccag ccgcccccac     4632

cccccaggac cccttagcag ccctgccctc cctatcgtct gaacagttgt cttcctcagc     4692

ctcctcccgc ccccaccttg ggaatgtaaa tacaccgtga ctttgaaagt ttgtacccct     4752

gtccttccct ttacgccact agtgtgtagg cagatgtctg agtccctagg tggtttctag     4812

gattgatagc aattagcttt gatgaaccca tcccaggaaa aataaaaaca gacaaaaaaa     4872

aaggaaagat tggttctccc agcactgctc agcagccaca gcctccctgt atgcctgtgc     4932

ttggtctact gataagccct ctacaaaaaa acaaaagtat atatatatat gtacataata     4992

tcagaattat aacaggcaaa taaaacctga aaatcaaaaa aaaaaaaaaa aaaa           5046


<210>  540
<211>  1257
<212>  PRT
<213>  Homo sapiens

<400>  540

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 
            20                  25                  30          


Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 
        35                  40                  45              


Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 
    50                  55                  60                  


Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 
65                  70                  75                  80  


Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr 
                85                  90                  95      


Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr 
            100                 105                 110         


Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile 
        115                 120                 125             


Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys 
    130                 135                 140                 


Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro 
145                 150                 155                 160 


Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile 
                165                 170                 175     


Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn 
            180                 185                 190         


Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile 
        195                 200                 205             


Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro 
    210                 215                 220                 


Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro 
225                 230                 235                 240 


Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln 
                245                 250                 255     


Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro 
            260                 265                 270         


Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val 
        275                 280                 285             


Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu 
    290                 295                 300                 


Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser 
305                 310                 315                 320 


Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu 
                325                 330                 335     


His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu 
            340                 345                 350         


Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile 
        355                 360                 365             


Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile 
    370                 375                 380                 


Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met 
385                 390                 395                 400 


Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn 
                405                 410                 415     


Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp 
            420                 425                 430         


Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys 
        435                 440                 445             


Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp 
    450                 455                 460                 


Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly 
465                 470                 475                 480 


Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe 
                485                 490                 495     


Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu 
            500                 505                 510         


Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile 
        515                 520                 525             


Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp 
    530                 535                 540                 


Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu 
545                 550                 555                 560 


Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu 
                565                 570                 575     


Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val 
            580                 585                 590         


Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val 
        595                 600                 605             


Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His 
    610                 615                 620                 


Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp 
625                 630                 635                 640 


His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu 
                645                 650                 655     


Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln 
            660                 665                 670         


Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg 
        675                 680                 685             


Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser 
    690                 695                 700                 


Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp 
705                 710                 715                 720 


Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys 
                725                 730                 735     


Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val 
            740                 745                 750         


Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val 
        755                 760                 765             


Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr 
    770                 775                 780                 


Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro 
785                 790                 795                 800 


Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro 
                805                 810                 815     


Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys 
            820                 825                 830         


Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr 
        835                 840                 845             


Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg 
    850                 855                 860                 


His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val 
865                 870                 875                 880 


Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln 
                885                 890                 895     


Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser 
            900                 905                 910         


Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys 
        915                 920                 925             


Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His 
    930                 935                 940                 


Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu 
945                 950                 955                 960 


Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg 
                965                 970                 975     


Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln 
            980                 985                 990         


Leu Gln Ala Thr Thr Lys Glu Gly  Pro Gly Glu Ala Ile  Val Arg Glu 
        995                 1000                 1005             


Gly Gly  Thr Met Ala Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile 
    1010                 1015                 1020             


Ser Ala  Thr Ala Gly Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro 
    1025                 1030                 1035             


Lys Glu  Gly Gln Cys Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala 
    1040                 1045                 1050             


Leu Gly  Glu Glu Lys Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val 
    1055                 1060                 1065             


Ser Tyr  Asn Gln Ser Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp 
    1070                 1075                 1080             


Thr Asp  Tyr Glu Ile His Leu  Phe Lys Glu Arg Met  Phe Arg His 
    1085                 1090                 1095             


Gln Met  Ala Val Lys Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro 
    1100                 1105                 1110             


Pro Ala  Gly Phe Ala Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser 
    1115                 1120                 1125             


Ala Ile  Ile Leu Leu Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile 
    1130                 1135                 1140             


Lys Arg  Ser Lys Gly Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp 
    1145                 1150                 1155             


Thr Gln  Val Asp Ser Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe 
    1160                 1165                 1170             


Gly Glu  Tyr Arg Ser Leu Glu  Ser Asp Asn Glu Glu  Lys Ala Phe 
    1175                 1180                 1185             


Gly Ser  Ser Gln Pro Ser Leu  Asn Gly Asp Ile Lys  Pro Leu Gly 
    1190                 1195                 1200             


Ser Asp  Asp Ser Leu Ala Asp  Tyr Gly Gly Ser Val  Asp Val Gln 
    1205                 1210                 1215             


Phe Asn  Glu Asp Gly Ser Phe  Ile Gly Gln Tyr Ser  Gly Lys Lys 
    1220                 1225                 1230             


Glu Lys  Glu Ala Ala Gly Gly  Asn Asp Ser Ser Gly  Ala Thr Ser 
    1235                 1240                 1245             


Pro Ile  Asn Pro Ala Val Ala  Leu Glu 
    1250                 1255         


<210>  541
<211>  3278
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (334)..(2211)

<400>  541
aggcacacag gcaaaatcaa gttctacatc tgtccctgtg tatgtcactt gtttgaatac       60

gaaataaaat taaaaaaata aattcagtgt attgagaaag caagcaattc tctcaaggta      120

tatttctgac atactaagat tttaacgact ttcacaaata tgctgtactg agagagaatg      180

ttacataaca ttgagaacta gtacaagtaa atattaaagt gaagtgacca tttcctacac      240

aagctcattc agaggaggat gaagaccatt ttggaggaag aaaagcaccc ttattaagaa      300

ttgcagcaag taagccaaca aggtcttttc agg atg att ttc tta tat caa gtg       354
                                     Met Ile Phe Leu Tyr Gln Val          
                                     1               5                    

gta cat ttc att tta ttt act tca gtt tct ggt gaa tgt gtg act cag        402
Val His Phe Ile Leu Phe Thr Ser Val Ser Gly Glu Cys Val Thr Gln           
        10                  15                  20                        

ttg ttg aag gac acc tgc ttt gaa gga ggg gac att act acg gtc ttc        450
Leu Leu Lys Asp Thr Cys Phe Glu Gly Gly Asp Ile Thr Thr Val Phe           
    25                  30                  35                            

aca cca agc gcc aag tac tgc cag gta gtc tgc act tac cac cca aga        498
Thr Pro Ser Ala Lys Tyr Cys Gln Val Val Cys Thr Tyr His Pro Arg           
40                  45                  50                  55            

tgt tta ctc ttc act ttc acg gcg gaa tca cca tct gag gat ccc acc        546
Cys Leu Leu Phe Thr Phe Thr Ala Glu Ser Pro Ser Glu Asp Pro Thr           
                60                  65                  70                

cga tgg ttt act tgt gtc ctg aaa gac agt gtt aca gaa aca ctg cca        594
Arg Trp Phe Thr Cys Val Leu Lys Asp Ser Val Thr Glu Thr Leu Pro           
            75                  80                  85                    

aga gtg aat agg aca gca gcg att tct ggg tat tct ttc aag caa tgc        642
Arg Val Asn Arg Thr Ala Ala Ile Ser Gly Tyr Ser Phe Lys Gln Cys           
        90                  95                  100                       

tca cac caa ata agc gct tgc aac aaa gac att tat gtg gac cta gac        690
Ser His Gln Ile Ser Ala Cys Asn Lys Asp Ile Tyr Val Asp Leu Asp           
    105                 110                 115                           

atg aag ggc ata aac tat aac agc tca gtt gcc aag agt gct caa gaa        738
Met Lys Gly Ile Asn Tyr Asn Ser Ser Val Ala Lys Ser Ala Gln Glu           
120                 125                 130                 135           

tgc caa gaa aga tgc acg gat gac gtc cac tgc cac ttt ttc acg tac        786
Cys Gln Glu Arg Cys Thr Asp Asp Val His Cys His Phe Phe Thr Tyr           
                140                 145                 150               

gcc aca agg cag ttt ccc agc ctg gag cat cgt aac att tgt cta ctg        834
Ala Thr Arg Gln Phe Pro Ser Leu Glu His Arg Asn Ile Cys Leu Leu           
            155                 160                 165                   

aag cac acc caa aca ggg aca cca acc aga ata acg aag ctc gat aaa        882
Lys His Thr Gln Thr Gly Thr Pro Thr Arg Ile Thr Lys Leu Asp Lys           
        170                 175                 180                       

gtg gtg tct gga ttt tca ctg aaa tcc tgt gca ctt tct aat ctg gct        930
Val Val Ser Gly Phe Ser Leu Lys Ser Cys Ala Leu Ser Asn Leu Ala           
    185                 190                 195                           

tgt att agg gac att ttc cct aat acg gtg ttt gca gac agc aac atc        978
Cys Ile Arg Asp Ile Phe Pro Asn Thr Val Phe Ala Asp Ser Asn Ile           
200                 205                 210                 215           

gac agt gtc atg gct ccc gat gct ttt gtc tgt ggc cga atc tgc act       1026
Asp Ser Val Met Ala Pro Asp Ala Phe Val Cys Gly Arg Ile Cys Thr           
                220                 225                 230               

cat cat ccc ggt tgc ttg ttt ttt acc ttc ttt tcc cag gaa tgg ccc       1074
His His Pro Gly Cys Leu Phe Phe Thr Phe Phe Ser Gln Glu Trp Pro           
            235                 240                 245                   

aaa gaa tct caa aga aat ctt tgt ctc ctt aaa aca tct gag agt gga       1122
Lys Glu Ser Gln Arg Asn Leu Cys Leu Leu Lys Thr Ser Glu Ser Gly           
        250                 255                 260                       

ttg ccc agt aca cgc att aaa aag agc aaa gct ctt tct ggt ttc agt       1170
Leu Pro Ser Thr Arg Ile Lys Lys Ser Lys Ala Leu Ser Gly Phe Ser           
    265                 270                 275                           

cta caa agc tgc agg cac agc atc cca gtg ttc tgc cat tct tca ttt       1218
Leu Gln Ser Cys Arg His Ser Ile Pro Val Phe Cys His Ser Ser Phe           
280                 285                 290                 295           

tac cat gac act gat ttc ttg gga gaa gaa ctg gat att gtt gct gca       1266
Tyr His Asp Thr Asp Phe Leu Gly Glu Glu Leu Asp Ile Val Ala Ala           
                300                 305                 310               

aaa agt cac gag gcc tgc cag aaa ctg tgc acc aat gcc gtc cgc tgc       1314
Lys Ser His Glu Ala Cys Gln Lys Leu Cys Thr Asn Ala Val Arg Cys           
            315                 320                 325                   

cag ttt ttt acc tat acc cca gcc caa gca tcc tgc aac gaa ggg aag       1362
Gln Phe Phe Thr Tyr Thr Pro Ala Gln Ala Ser Cys Asn Glu Gly Lys           
        330                 335                 340                       

ggc aag tgt tac tta aag ctt tct tca aac gga tct cca act aaa ata       1410
Gly Lys Cys Tyr Leu Lys Leu Ser Ser Asn Gly Ser Pro Thr Lys Ile           
    345                 350                 355                           

ctt cac ggg aga gga ggc atc tct gga tac aca tta agg ttg tgt aaa       1458
Leu His Gly Arg Gly Gly Ile Ser Gly Tyr Thr Leu Arg Leu Cys Lys           
360                 365                 370                 375           

atg gat aat gag tgt acc acc aaa atc aag ccc agg atc gtt gga gga       1506
Met Asp Asn Glu Cys Thr Thr Lys Ile Lys Pro Arg Ile Val Gly Gly           
                380                 385                 390               

act gcg tct gtt cgt ggt gag tgg ccg tgg cag gtg acc ctg cac aca       1554
Thr Ala Ser Val Arg Gly Glu Trp Pro Trp Gln Val Thr Leu His Thr           
            395                 400                 405                   

acc tca ccc act cag aga cac ctg tgt gga ggc tcc atc att gga aac       1602
Thr Ser Pro Thr Gln Arg His Leu Cys Gly Gly Ser Ile Ile Gly Asn           
        410                 415                 420                       

cag tgg ata tta aca gcc gct cac tgt ttc tat ggg gta gag tca cct       1650
Gln Trp Ile Leu Thr Ala Ala His Cys Phe Tyr Gly Val Glu Ser Pro           
    425                 430                 435                           

aag att ttg cgt gtc tac agt ggc att tta aat caa tct gaa ata aaa       1698
Lys Ile Leu Arg Val Tyr Ser Gly Ile Leu Asn Gln Ser Glu Ile Lys           
440                 445                 450                 455           

gag gac aca tct ttc ttt ggg gtt caa gaa ata ata atc cat gat cag       1746
Glu Asp Thr Ser Phe Phe Gly Val Gln Glu Ile Ile Ile His Asp Gln           
                460                 465                 470               

tat aaa atg gca gaa agc ggg tat gat att gcc ttg ttg aaa ctg gaa       1794
Tyr Lys Met Ala Glu Ser Gly Tyr Asp Ile Ala Leu Leu Lys Leu Glu           
            475                 480                 485                   

acc aca gtg aat tac aca gat tct caa cga ccc ata tgc ctg cct tcc       1842
Thr Thr Val Asn Tyr Thr Asp Ser Gln Arg Pro Ile Cys Leu Pro Ser           
        490                 495                 500                       

aaa gga gat aga aat gta ata tac act gat tgc tgg gtg act gga tgg       1890
Lys Gly Asp Arg Asn Val Ile Tyr Thr Asp Cys Trp Val Thr Gly Trp           
    505                 510                 515                           

ggg tac aga aaa cta aga gac aaa ata caa aat act ctc cag aaa gcc       1938
Gly Tyr Arg Lys Leu Arg Asp Lys Ile Gln Asn Thr Leu Gln Lys Ala           
520                 525                 530                 535           

aag ata ccc tta gtg acc aac gaa gag tgc cag aag aga tac aga gga       1986
Lys Ile Pro Leu Val Thr Asn Glu Glu Cys Gln Lys Arg Tyr Arg Gly           
                540                 545                 550               

cat aaa ata acc cat aag atg atc tgt gcc ggc tac agg gaa gga ggg       2034
His Lys Ile Thr His Lys Met Ile Cys Ala Gly Tyr Arg Glu Gly Gly           
            555                 560                 565                   

aag gac gct tgc aag gga gat tcg gga ggc cct ctg tcc tgc aaa cac       2082
Lys Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Ser Cys Lys His           
        570                 575                 580                       

aat gag gtc tgg cat ctg gta ggc atc acg agc tgg ggc gaa ggc tgt       2130
Asn Glu Val Trp His Leu Val Gly Ile Thr Ser Trp Gly Glu Gly Cys           
    585                 590                 595                           

gct caa agg gag cgg cca ggt gtt tac acc aac gtg gtc gag tac gtg       2178
Ala Gln Arg Glu Arg Pro Gly Val Tyr Thr Asn Val Val Glu Tyr Val           
600                 605                 610                 615           

gac tgg att ctg gag aaa act caa gca gtg tga atgggttccc aggggccatt     2231
Asp Trp Ile Leu Glu Lys Thr Gln Ala Val                                   
                620                 625                                   

ggagtccctg aaggacccag gatttgctgg gagagggtgt tgagttcact gtgccagcat     2291

gcttcctcca cagtaacacg ctgaaggggc ttggtgtttg taagaaaatg ctagaagaaa     2351

acaaactgtc acaagttgtt atgtccaaaa ctcccgttct atgatcgttg tagtttgttt     2411

gagcattcag tctctttgtt tttgatcacg cttctatgga gtccaagaat taccataagg     2471

caatatttct gaagattact atataggcag atatagcaga aaataaccaa gtagtggcag     2531

tggggatcag gcagaagaac tggtaaaaga agccaccata aatagatttg ttcgatgaaa     2591

gatgaaaact ggaagaaagg agaacaaaga cagtcttcac cattttgcag gaatctacac     2651

tctgcctatg tgaacacatt tcttttgtaa agaaagaaat tgattgcatt taatggcaga     2711

ttttcagaat agtcaggaat tcttgtcatt tccattttaa aatatatatt aaaaaaaatc     2771

agttcgagta gacacgagct aagagtgaat gtgaagataa cagaatttct gtgtggaaga     2831

ggattacaag cagcaattta cctggaagtg ataccttagg ggcaatcttg aagatacact     2891

ttcctgaaaa atgatttgtg atggattgta tatttattta aaatatcttg ggaggggagg     2951

ctgatggaga tagggagcat gctcaaacct ccctaagaca agctgctgct gtgactatgg     3011

gctcccaaag agctagatcg tatatttatt tgacaaaaat caccatagac tgcatccata     3071

ctacagagaa aaaacaatta gggcgcaaat ggatagttac agtaaagtct tcagcaagca     3131

gctgcctgta ttctaagcac tgggattttc tgtttcgtgc aaatatttat ctcattattg     3191

ttgtgatcta gttcaataac ctagaatttg aattgtcacc acatagcttt caatctgtgc     3251

caacaactat acaattcatc aagtgtg                                         3278


<210>  542
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  542

Met Ile Phe Leu Tyr Gln Val Val His Phe Ile Leu Phe Thr Ser Val 
1               5                   10                  15      


Ser Gly Glu Cys Val Thr Gln Leu Leu Lys Asp Thr Cys Phe Glu Gly 
            20                  25                  30          


Gly Asp Ile Thr Thr Val Phe Thr Pro Ser Ala Lys Tyr Cys Gln Val 
        35                  40                  45              


Val Cys Thr Tyr His Pro Arg Cys Leu Leu Phe Thr Phe Thr Ala Glu 
    50                  55                  60                  


Ser Pro Ser Glu Asp Pro Thr Arg Trp Phe Thr Cys Val Leu Lys Asp 
65                  70                  75                  80  


Ser Val Thr Glu Thr Leu Pro Arg Val Asn Arg Thr Ala Ala Ile Ser 
                85                  90                  95      


Gly Tyr Ser Phe Lys Gln Cys Ser His Gln Ile Ser Ala Cys Asn Lys 
            100                 105                 110         


Asp Ile Tyr Val Asp Leu Asp Met Lys Gly Ile Asn Tyr Asn Ser Ser 
        115                 120                 125             


Val Ala Lys Ser Ala Gln Glu Cys Gln Glu Arg Cys Thr Asp Asp Val 
    130                 135                 140                 


His Cys His Phe Phe Thr Tyr Ala Thr Arg Gln Phe Pro Ser Leu Glu 
145                 150                 155                 160 


His Arg Asn Ile Cys Leu Leu Lys His Thr Gln Thr Gly Thr Pro Thr 
                165                 170                 175     


Arg Ile Thr Lys Leu Asp Lys Val Val Ser Gly Phe Ser Leu Lys Ser 
            180                 185                 190         


Cys Ala Leu Ser Asn Leu Ala Cys Ile Arg Asp Ile Phe Pro Asn Thr 
        195                 200                 205             


Val Phe Ala Asp Ser Asn Ile Asp Ser Val Met Ala Pro Asp Ala Phe 
    210                 215                 220                 


Val Cys Gly Arg Ile Cys Thr His His Pro Gly Cys Leu Phe Phe Thr 
225                 230                 235                 240 


Phe Phe Ser Gln Glu Trp Pro Lys Glu Ser Gln Arg Asn Leu Cys Leu 
                245                 250                 255     


Leu Lys Thr Ser Glu Ser Gly Leu Pro Ser Thr Arg Ile Lys Lys Ser 
            260                 265                 270         


Lys Ala Leu Ser Gly Phe Ser Leu Gln Ser Cys Arg His Ser Ile Pro 
        275                 280                 285             


Val Phe Cys His Ser Ser Phe Tyr His Asp Thr Asp Phe Leu Gly Glu 
    290                 295                 300                 


Glu Leu Asp Ile Val Ala Ala Lys Ser His Glu Ala Cys Gln Lys Leu 
305                 310                 315                 320 


Cys Thr Asn Ala Val Arg Cys Gln Phe Phe Thr Tyr Thr Pro Ala Gln 
                325                 330                 335     


Ala Ser Cys Asn Glu Gly Lys Gly Lys Cys Tyr Leu Lys Leu Ser Ser 
            340                 345                 350         


Asn Gly Ser Pro Thr Lys Ile Leu His Gly Arg Gly Gly Ile Ser Gly 
        355                 360                 365             


Tyr Thr Leu Arg Leu Cys Lys Met Asp Asn Glu Cys Thr Thr Lys Ile 
    370                 375                 380                 


Lys Pro Arg Ile Val Gly Gly Thr Ala Ser Val Arg Gly Glu Trp Pro 
385                 390                 395                 400 


Trp Gln Val Thr Leu His Thr Thr Ser Pro Thr Gln Arg His Leu Cys 
                405                 410                 415     


Gly Gly Ser Ile Ile Gly Asn Gln Trp Ile Leu Thr Ala Ala His Cys 
            420                 425                 430         


Phe Tyr Gly Val Glu Ser Pro Lys Ile Leu Arg Val Tyr Ser Gly Ile 
        435                 440                 445             


Leu Asn Gln Ser Glu Ile Lys Glu Asp Thr Ser Phe Phe Gly Val Gln 
    450                 455                 460                 


Glu Ile Ile Ile His Asp Gln Tyr Lys Met Ala Glu Ser Gly Tyr Asp 
465                 470                 475                 480 


Ile Ala Leu Leu Lys Leu Glu Thr Thr Val Asn Tyr Thr Asp Ser Gln 
                485                 490                 495     


Arg Pro Ile Cys Leu Pro Ser Lys Gly Asp Arg Asn Val Ile Tyr Thr 
            500                 505                 510         


Asp Cys Trp Val Thr Gly Trp Gly Tyr Arg Lys Leu Arg Asp Lys Ile 
        515                 520                 525             


Gln Asn Thr Leu Gln Lys Ala Lys Ile Pro Leu Val Thr Asn Glu Glu 
    530                 535                 540                 


Cys Gln Lys Arg Tyr Arg Gly His Lys Ile Thr His Lys Met Ile Cys 
545                 550                 555                 560 


Ala Gly Tyr Arg Glu Gly Gly Lys Asp Ala Cys Lys Gly Asp Ser Gly 
                565                 570                 575     


Gly Pro Leu Ser Cys Lys His Asn Glu Val Trp His Leu Val Gly Ile 
            580                 585                 590         


Thr Ser Trp Gly Glu Gly Cys Ala Gln Arg Glu Arg Pro Gly Val Tyr 
        595                 600                 605             


Thr Asn Val Val Glu Tyr Val Asp Trp Ile Leu Glu Lys Thr Gln Ala 
    610                 615                 620                 


Val 
625 


<210>  543
<211>  4236
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (135)..(1379)

<400>  543
ggtgggcggg gggaggaggc ggccctagcg ccattttgtg ggagcgaagc ggtggctggg       60

ctgcgcttgg gtccgtcgct gcttcggtgt ccctgtcggg cttcccagca gcggcctagc      120

gggaaaagta aaag atg tct gaa tat att cgg gta acc gaa gat gag aac        170
                Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn           
                1               5                   10                    

gat gag ccc att gaa ata cca tcg gaa gac gat ggg acg gtg ctg ctc        218
Asp Glu Pro Ile Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu           
        15                  20                  25                        

tcc acg gtt aca gcc cag ttt cca ggg gcg tgt ggg ctt cgc tac agg        266
Ser Thr Val Thr Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg           
    30                  35                  40                            

aat cca gtg tct cag tgt atg aga ggt gtc cgg ctg gta gaa gga att        314
Asn Pro Val Ser Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile           
45                  50                  55                  60            

ctg cat gcc cca gat gct ggc tgg gga aat ctg gtg tat gtt gtc aac        362
Leu His Ala Pro Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn           
                65                  70                  75                

tat cca aaa gat aac aaa aga aaa atg gat gag aca gat gct tca tca        410
Tyr Pro Lys Asp Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser           
            80                  85                  90                    

gca gtg aaa gtg aaa aga gca gtc cag aaa aca tcc gat tta ata gtg        458
Ala Val Lys Val Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val           
        95                  100                 105                       

ttg ggt ctc cca tgg aaa aca acc gaa cag gac ctg aaa gag tat ttt        506
Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe           
    110                 115                 120                           

agt acc ttt gga gaa gtt ctt atg gtg cag gtc aag aaa gat ctt aag        554
Ser Thr Phe Gly Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys           
125                 130                 135                 140           

act ggt cat tca aag ggg ttt ggc ttt gtt cgt ttt acg gaa tat gaa        602
Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu           
                145                 150                 155               

aca caa gtg aaa gta atg tca cag cga cat atg ata gat gga cga tgg        650
Thr Gln Val Lys Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp           
            160                 165                 170                   

tgt gac tgc aaa ctt cct aat tct aag caa agc caa gat gag cct ttg        698
Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu           
        175                 180                 185                       

aga agc aga aaa gtg ttt gtg ggg cgc tgt aca gag gac atg act gag        746
Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu           
    190                 195                 200                           

gat gag ctg cgg gag ttc ttc tct cag tac ggg gat gtg atg gat gtc        794
Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val           
205                 210                 215                 220           

ttc atc ccc aag cca ttc agg gcc ttt gcc ttt gtt aca ttt gca gat        842
Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp           
                225                 230                 235               

gat cag att gcg cag tct ctt tgt gga gag gac ttg atc att aaa gga        890
Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly           
            240                 245                 250                   

atc agc gtt cat ata tcc aat gcc gaa cct aag cac aat agc aat aga        938
Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg           
        255                 260                 265                       

cag tta gaa aga agt gga aga ttt ggt ggt aat cca ggt ggc ttt ggg        986
Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly           
    270                 275                 280                           

aat cag ggt gga ttt ggt aat agc aga ggg ggt gga gct ggt ttg gga       1034
Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly           
285                 290                 295                 300           

aac aat caa ggt agt aat atg ggt ggt ggg atg aac ttt ggt gcg ttc       1082
Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe           
                305                 310                 315               

agc att aat cca gcc atg atg gct gcc gcc cag gca gca cta cag agc       1130
Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser           
            320                 325                 330                   

agt tgg ggt atg atg ggc atg tta gcc agc cag cag aac cag tca ggc       1178
Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly           
        335                 340                 345                       

cca tcg ggt aat aac caa aac caa ggc aac atg cag agg gag cca aac       1226
Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn           
    350                 355                 360                           

cag gcc ttc ggt tct gga aat aac tct tat agt ggc tct aat tct ggt       1274
Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly           
365                 370                 375                 380           

gca gca att ggt tgg gga tca gca tcc aat gca ggg tcg ggc agt ggt       1322
Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly           
                385                 390                 395               

ttt aat gga ggc ttt ggc tca agc atg gat tct aag tct tct ggc tgg       1370
Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp           
            400                 405                 410                   

gga atg tag acagtggggt tgtggttggt tggtatagaa tggtgggaat               1419
Gly Met                                                                   
                                                                          

tcaaattttt ctaaactcat ggtaagtata ttgtaaaata catatgtact aagaattttc     1479

aaaattggtt tgttcagtgt ggagtatatt cagcagtatt tttgacattt ttctttagaa     1539

aaaggaagag ctaaaggaat tttataagtt ttgttacatg aaaggttgaa atattgagtg     1599

gttgaaagtg aactgctgtt tgcctgattg gtaaaccaac acactacaat tgatatcaaa     1659

aggtttctcc tgtaatattt tatccctgga cttgtcaagt gaattctttg catgttcaaa     1719

acggaaacca ttgattagaa ctacattctt taccccttgt tttaatttga accccaccat     1779

atggattttt ttccttaaga aaatctcctt ttaggagatc atggtgtcac agtgtttggt     1839

tcttttgttt tgttttttaa cacttgtctc ccctcataca caaaagtaca atatgaagcc     1899

ttcatttaat ctctgcagtt catctcattt caaatgttta tggaagaagc acttcattga     1959

aagtagtgct gtaaatattc tgccatagga atactgtcta catgctttct cattcaagaa     2019

ttcgtcatca cgcatcacag gccgcgtctt tgacggtggg tgtcccattt ttatccgcta     2079

ctctttattt catggagtcg tatcaacgct atgaacgcaa ggctgtgata tggaaccaga     2139

aggctgtctg aacttttgaa accttgtgtg ggattgatgg tggtgccgag gcatgaaagg     2199

ctagtatgag cgagaaaagg agagagcgcg tgcagagact tggtggtgca taatggatat     2259

tttttaactt ggcgagatgt gtctctcaat cctgtggctt tggtgagaga gtgtgcagag     2319

agcaatgata gcaaataatg tacgaatgtt ttttgcattc aaaggacatc cacatctgtt     2379

ggaagacttt taagtgagtt tttgttctta gataacccac attagatgaa tgtgttaagt     2439

gaaatgatac ttgtactccc cctacccctt tgtcaactgc tgtgaatgct gtatggtgtg     2499

tgttctcttc tgttactgat atgtaagtgt ggcaatgtga actgaagctg atgggctgag     2559

aacatggact gagcttgtgg tgtgctttgc aggaggactt gaagcagagt tcaccagtga     2619

gctcaggtgt ctcaaagaag ggtggaagtt ctaatgtctg ttagctaccc ataagaatgc     2679

tgtttgctgc agttctgtgt cctgtgcttg gatgcttttt ataagagttg tcattgttgg     2739

aaattcttaa ataaaactga tttaaataat atgtgtcttt gttttgcagc cctgaatgca     2799

aagaattcat agcagttaat tccccttttt tgaccctttt gagatggaac tttcataaag     2859

tttcttggca gtagtttatt ttgcttcaaa taaacttatt tgaaaagttg tctcaagtca     2919

aatggattca tcacctgtca tgcattgaca cctgataccc agacttaatt ggtatttgtt     2979

cttgcattgg ccaaagtgaa aatttttttt tttcttttga aatctagttt tgaataagtc     3039

tgggtgaccg cacctaaaat ggtaagcagt accctccggc tttttcttag tgcctctgtg     3099

catttgggtg atgttctatt tacatggcct gtgtaaatct ccattgggaa gtcatgcctt     3159

ctaaaaagat tcttatttgg gggagtgggc aaaatgttga ttattttcta atgctttgta     3219

gcaaagcata tcaattgaaa agggaatatc agcaccttcc tagtttggga tttgaaaagt     3279

ggaattaatt gcagtaggga taaagtagaa gaaaccacaa attatcttgt gcctgaaatc     3339

cattaagagg cctgatagct ttaagaatta gggtgggttg tctgtctgga agtgttaagt     3399

ggaatgggct ttgtcctcca ggaggtgggg gaatgtggta acattgaata cagttgaata     3459

aaatcgctta caaaactcac actctcacaa tgcattgtta agtatgtaaa agcaataaca     3519

ttgattctct gttgtacttt tttgtaacta attctgtgag agttgagctc attttctagt     3579

tggaagaatg tgatatttgt tgtgttggta gtttacctaa tgcccttacc taattagatt     3639

atgataaata ggtttgtcat tttgcaagtt acataaacat ttatcaatga agtcatcctt     3699

tagacttgta atcgccacat tgtttcatta ttcagtttcc tctgtaaagg gatcttgagt     3759

tgttttaatt ttttttttct gcatctgaat ctgcatgatt tccaaaccct gtaccatctg     3819

aattttgcat tttagcactt gcactattac tcagcagcag taacatggta acacttaaaa     3879

tggtactcgg ggacctccaa agactaaact gacaagcctt caaggagccc aggggtaagt     3939

taacttgtca acggcatggt ttaatccctt ctttacactt gtgtaaattt cagttactgg     3999

tcatagaagg ctttcaatgt tgagtggcct tttattaaca tgtttatggt actgcataga     4059

tacgggtatt tattttaccc taagaagatt ttgaagttta aaagtactta aactatttgg     4119

caaagatttg tttttaaaaa tctatttggt caatctaaat gcattcattc taaaaaattt     4179

tttgaaccag ataaataaaa tttttttttg acaccacaaa aaaaaaaaaa aaaaaaa        4236


<210>  544
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  544

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190         


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205             


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220                 


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240 


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255     


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270         


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285             


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300                 


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335     


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350         


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365             


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380                 


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410                 


<210>  545
<211>  1550
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (81)..(947)

<400>  545
tcaacgcctg cctcccctcg agcgtcctca gcgcagccgc cgcccgcgga gccagcacga       60

acgagcccag caccggccgg atg gag cgt ccg caa ccc gac agc atg ccc cag      113
                      Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln         
                      1               5                   10              

gat ttg tca gag gcc ctg aag gag gcc acc aag gag gtg cac acc cag        161
Asp Leu Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln           
            15                  20                  25                    

gca gag aat gct gag ttc atg agg aac ttt cag aag ggc cag gtg acc        209
Ala Glu Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr           
        30                  35                  40                        

cga gac ggc ttc aag ctg gtg atg gcc tcc ctg tac cac atc tat gtg        257
Arg Asp Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val           
    45                  50                  55                            

gcc ctg gag gag gag att gag cgc aac aag gag agc cca gtc ttc gcc        305
Ala Leu Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala           
60                  65                  70                  75            

cct gtc tac ttc cca gaa gag ctg cac cgc aag gct gcc ctg gag cag        353
Pro Val Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln           
                80                  85                  90                

gac ctg gcc ttc tgg tac ggg ccc cgc tgg cag gag gtc atc ccc tac        401
Asp Leu Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr           
            95                  100                 105                   

aca cca gcc atg cag cgc tat gtg aag cgg ctc cac gag gtg ggg cgc        449
Thr Pro Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg           
        110                 115                 120                       

aca gag ccc gag ctg ctg gtg gcc cac gcc tac acc cgc tac ctg ggt        497
Thr Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly           
    125                 130                 135                           

gac ctg tct ggg ggc cag gtg ctc aaa aag att gcc cag aaa gcc ctg        545
Asp Leu Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu           
140                 145                 150                 155           

gac ctg ccc agc tct ggc gag ggc ctg gcc ttc ttc acc ttc ccc aac        593
Asp Leu Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn           
                160                 165                 170               

att gcc agt gcc acc aag ttc aag cag ctc tac cgc tcc cgc atg aac        641
Ile Ala Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn           
            175                 180                 185                   

tcc ctg gag atg act ccc gca gtc agg cag agg gtg ata gaa gag gcc        689
Ser Leu Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala           
        190                 195                 200                       

aag act gcg ttc ctg ctc aac atc cag ctc ttt gag gag ttg cag gag        737
Lys Thr Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu           
    205                 210                 215                           

ctg ctg acc cat gac acc aag gac cag agc ccc tca cgg gca cca ggg        785
Leu Leu Thr His Asp Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly           
220                 225                 230                 235           

ctt cgc cag cgg gcc agc aac aaa gtg caa gat tct gcc ccc gtg gag        833
Leu Arg Gln Arg Ala Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu           
                240                 245                 250               

act ccc aga ggg aag ccc cca ctc aac acc cgc tcc cag gct ccg ctt        881
Thr Pro Arg Gly Lys Pro Pro Leu Asn Thr Arg Ser Gln Ala Pro Leu           
            255                 260                 265                   

ctc cga tgg gtc ctt aca ctc agc ttt ctg gtg gcg aca gtt gct gta        929
Leu Arg Trp Val Leu Thr Leu Ser Phe Leu Val Ala Thr Val Ala Val           
        270                 275                 280                       

ggg ctt tat gcc atg tga atgcaggcat gctggctccc agggccatga               977
Gly Leu Tyr Ala Met                                                       
    285                                                                   

actttgtccg gtggaaggcc ttctttctag agagggaatt ctcttggctg gcttccttac     1037

cgtgggcact gaaggctttc agggcctcca gccctctcac tgtgtccctc tctctggaaa     1097

ggaggaagga gcctatggca tcttccccaa cgaaaagcac atccaggcaa tggcctaaac     1157

ttcagagggg gcgaaggggt cagccctgcc cttcagcatc ctcagttcct gcagcagagc     1217

ctggaagaca ccctaatgtg gcagctgtct caaacctcca aaagccctga gtttcaagta     1277

tccttgttga cacggccatg accactttcc ccgtgggcca tggcaatttt tacacaaacc     1337

tgaaaagatg ttgtgtcttg tgtttttgtc ttatttttgt tggagccact ctgttcctgg     1397

ctcagcctca aatgcagtat ttttgttgtg ttctgttgtt tttatagcag ggttggggtg     1457

gtttttgagc catgcgtggg tggggaggga ggtgtttaac ggcactgtgg ccttggtcta     1517

acttttgtgt gaaataataa acaacattgt ctg                                  1550


<210>  546
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  546

Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Arg Ser Gln Ala Pro Leu Leu Arg Trp Val Leu 
            260                 265                 270         


Thr Leu Ser Phe Leu Val Ala Thr Val Ala Val Gly Leu Tyr Ala Met 
        275                 280                 285             


<210>  547
<211>  3718
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (269)..(1735)

<400>  547
cgcctcaggt cggccgcgga ctacaaatgg acgagagagg cggccgtcca ttagttagcg       60

gctccggagc aacgcagccg ttgtccttga ggccgacggg cctgacgcgg gcgggttgaa      120

cgcgctggtg aggcggtcac ccgggctacg gcggccggca gggggcagtg gcggccgttg      180

tctagggccc ggaggtgggg ccgcgcgcct cgggcgctac gaacccggca ggcccacgct      240

tggctgcggc cgggtgcggg ctgaggcc atg ggc gac cgc ggc agc tcc cgg         292
                               Met Gly Asp Arg Gly Ser Ser Arg            
                               1               5                          

cgc cgg agg aca ggg tcg cgg ccc tcg agc cac ggc ggc ggc ggg cct        340
Arg Arg Arg Thr Gly Ser Arg Pro Ser Ser His Gly Gly Gly Gly Pro           
    10                  15                  20                            

gcg gcg gcg gaa gag gag gtg cgg gac gcc gct gcg ggc ccc gac gtg        388
Ala Ala Ala Glu Glu Glu Val Arg Asp Ala Ala Ala Gly Pro Asp Val           
25                  30                  35                  40            

gga gcc gcg ggg gac gcg cca gcc ccg gcc ccc aac aag gac gga gac        436
Gly Ala Ala Gly Asp Ala Pro Ala Pro Ala Pro Asn Lys Asp Gly Asp           
                45                  50                  55                

gcc ggc gtg ggc agc ggc cac tgg gag ctg agg tgc cat cgc ctg cag        484
Ala Gly Val Gly Ser Gly His Trp Glu Leu Arg Cys His Arg Leu Gln           
            60                  65                  70                    

gat tct tta ttc agc tct gac agt ggc ttc agc aac tac cgt ggc atc        532
Asp Ser Leu Phe Ser Ser Asp Ser Gly Phe Ser Asn Tyr Arg Gly Ile           
        75                  80                  85                        

ctg aac tgg tgt gtg gtg atg ctg atc ttg agc aat gcc cgg tta ttt        580
Leu Asn Trp Cys Val Val Met Leu Ile Leu Ser Asn Ala Arg Leu Phe           
    90                  95                  100                           

ctg gag aac ctc atc aag tat ggc atc ctg gtg gac ccc atc cag gtg        628
Leu Glu Asn Leu Ile Lys Tyr Gly Ile Leu Val Asp Pro Ile Gln Val           
105                 110                 115                 120           

gtt tct ctg ttc ctg aag gat ccc tat agc tgg ccc gcc cca tgc ctg        676
Val Ser Leu Phe Leu Lys Asp Pro Tyr Ser Trp Pro Ala Pro Cys Leu           
                125                 130                 135               

gtt att gcg gcc aat gtc ttt gct gtg gct gca ttc cag gtt gag aag        724
Val Ile Ala Ala Asn Val Phe Ala Val Ala Ala Phe Gln Val Glu Lys           
            140                 145                 150                   

cgc ctg gcg gtg ggt gcc ctg acg gag cag gcg gga ctg ctg ctg cac        772
Arg Leu Ala Val Gly Ala Leu Thr Glu Gln Ala Gly Leu Leu Leu His           
        155                 160                 165                       

gtg gcc aac ctg gcc acc att ctg tgt ttc cca gcg gct gtg gtc tta        820
Val Ala Asn Leu Ala Thr Ile Leu Cys Phe Pro Ala Ala Val Val Leu           
    170                 175                 180                           

ctg gtt gag tct atc act cca gtg ggc tcc ctg ctg gcg ctg atg gcg        868
Leu Val Glu Ser Ile Thr Pro Val Gly Ser Leu Leu Ala Leu Met Ala           
185                 190                 195                 200           

cac acc atc ctc ttc ctc aag ctc ttc tcc tac cgc gac gtc aac tca        916
His Thr Ile Leu Phe Leu Lys Leu Phe Ser Tyr Arg Asp Val Asn Ser           
                205                 210                 215               

tgg tgc cgc agg gcc agg gcc aag gct gcc tct gca ggg aag aag gcc        964
Trp Cys Arg Arg Ala Arg Ala Lys Ala Ala Ser Ala Gly Lys Lys Ala           
            220                 225                 230                   

agc agt gct gct gcc ccg cac acc gtg agc tac ccg gac aat ctg acc       1012
Ser Ser Ala Ala Ala Pro His Thr Val Ser Tyr Pro Asp Asn Leu Thr           
        235                 240                 245                       

tac cgc gat ctc tac tac ttc ctc ttc gcc ccc acc ttg tgc tac gag       1060
Tyr Arg Asp Leu Tyr Tyr Phe Leu Phe Ala Pro Thr Leu Cys Tyr Glu           
    250                 255                 260                           

ctc aac ttt ccc cgc tct ccc cgc atc cgg aag cgc ttt ctg ctg cga       1108
Leu Asn Phe Pro Arg Ser Pro Arg Ile Arg Lys Arg Phe Leu Leu Arg           
265                 270                 275                 280           

cgg atc ctt gag atg ctg ttc ttc acc cag ctc cag gtg ggg ctg atc       1156
Arg Ile Leu Glu Met Leu Phe Phe Thr Gln Leu Gln Val Gly Leu Ile           
                285                 290                 295               

cag cag tgg atg gtc ccc acc atc cag aac tcc atg aag ccc ttc aag       1204
Gln Gln Trp Met Val Pro Thr Ile Gln Asn Ser Met Lys Pro Phe Lys           
            300                 305                 310                   

gac atg gac tac tca cgc atc atc gag cgc ctc ctg aag ctg gcg gtc       1252
Asp Met Asp Tyr Ser Arg Ile Ile Glu Arg Leu Leu Lys Leu Ala Val           
        315                 320                 325                       

ccc aat cac ctc atc tgg ctc atc ttc ttc tac tgg ctc ttc cac tcc       1300
Pro Asn His Leu Ile Trp Leu Ile Phe Phe Tyr Trp Leu Phe His Ser           
    330                 335                 340                           

tgc ctg aat gcc gtg gct gag ctc atg cag ttt gga gac cgg gag ttc       1348
Cys Leu Asn Ala Val Ala Glu Leu Met Gln Phe Gly Asp Arg Glu Phe           
345                 350                 355                 360           

tac cgg gac tgg tgg aac tcc gag tct gtc acc tac ttc tgg cag aac       1396
Tyr Arg Asp Trp Trp Asn Ser Glu Ser Val Thr Tyr Phe Trp Gln Asn           
                365                 370                 375               

tgg aac atc cct gtg cac aag tgg tgc atc aga cac ttc tac aag ccc       1444
Trp Asn Ile Pro Val His Lys Trp Cys Ile Arg His Phe Tyr Lys Pro           
            380                 385                 390                   

atg ctt cga cgg ggc agc agc aag tgg atg gcc agg aca ggg gtg ttc       1492
Met Leu Arg Arg Gly Ser Ser Lys Trp Met Ala Arg Thr Gly Val Phe           
        395                 400                 405                       

ctg gcc tcg gcc ttc ttc cac gag tac ctg gtg agc gtc cct ctg cga       1540
Leu Ala Ser Ala Phe Phe His Glu Tyr Leu Val Ser Val Pro Leu Arg           
    410                 415                 420                           

atg ttc cgc ctc tgg gcg ttc acg ggc atg atg gct cag atc cca ctg       1588
Met Phe Arg Leu Trp Ala Phe Thr Gly Met Met Ala Gln Ile Pro Leu           
425                 430                 435                 440           

gcc tgg ttc gtg ggc cgc ttt ttc cag ggc aac tat ggc aac gca gct       1636
Ala Trp Phe Val Gly Arg Phe Phe Gln Gly Asn Tyr Gly Asn Ala Ala           
                445                 450                 455               

gtg tgg ctg tcg ctc atc atc gga cag cca ata gcc gtc ctc atg tac       1684
Val Trp Leu Ser Leu Ile Ile Gly Gln Pro Ile Ala Val Leu Met Tyr           
            460                 465                 470                   

gtc cac gac tac tac gtg ctc aac tat gag gcc cca gcg gca gag gcc       1732
Val His Asp Tyr Tyr Val Leu Asn Tyr Glu Ala Pro Ala Ala Glu Ala           
        475                 480                 485                       

tga gctgcacctg agggcctggc ttctcactgc cacctcacac ccgctgccag            1785

agcccacctc tcctcctagg cctcgagtgc tggggatggg cctggctgca cagcatcctc     1845

ctctggtccc agggaggcct ctctgcccct atggggctct gtcctgcacc cctcagggat     1905

ggcgacagca ggccagacac agtctgatgc cagctgggag tcttgctgac cctgccccgg     1965

gtccgagggt gtcaataaag tgctgtccag tgacctcttc agcctgccag gggcctgggg     2025

cctggtgggg ggtatggcca cacccacaag ggcgagtgcc agagctgtgt ggacagctgt     2085

cccaggacct gccggggagc agcagctcca ctgcagcagg gcgggcatgg ccggtagggg     2145

gagtgcaagg ccaggcagac gcccccattc cccacactcc cctacctaga aaagctcagc     2205

tcaggcgtcc tctcctggtg ctactcctgc tgggtgtgcg ggaatcggca ctctggccct     2265

cagtgcagga tggtcaactt gcacccaccg tgctcagctt cagcttggga agaggtcggc     2325

cctgggtttg cgggaagtgg gctccagcca ggatggccca gggatgggca gtccacaggg     2385

cctttctggt gtgggtctgg tgagccgagg ggctacggta cacaatggct atgtccatgg     2445

ctattcgcct tggggcaggg ctcggtttgg cagcctcttt ccttcacttg gaacctgggc     2505

agccaggtgg gctggtggct ctcagctgcc ctccacgagg ttggggcacc cctgatcccc     2565

aggcctgcct tgccctctgc tcttctggca ccaggctggg cagtgcagac agcgcagccc     2625

tgcagccttc aggacacctt gttcccaggc cctgcaatcc accaagctgg atagatgggg     2685

ccccccttga tggtagcggg aggtcagggg taaccccagg gccctgctgc tgccttacct     2745

tgctggggtg actgcttgat taaagacccc aagactggac caggccctgg tgtccccaga     2805

cctgcagcta tggcccaaca aggcaggtgt ttgaggaggc cctgcacagg gtcccaggac     2865

tgcaccaggg gcctcatcag caacctgctg aactggtggt gtgaggggag ggtgggctcc     2925

cttggtggta tcctccctct accccagtgg gggctggtgg gccctgagat ggaggcatct     2985

ccttgggccc tgctgaggat ggcagtagtg ggtgagctcc tggtgggggg atgggtgtgg     3045

ggccgactcc tccatcccac atgggctcct gtgcctctcc ctatcagttg gccagtggag     3105

ctcgagaaca aactgttgct gccagataaa gcagcaaagc ctgctccact gcccagcgca     3165

ggcccccttc ccttcctcca ccaggctgag tggagaaccc taaagctacg ggacaggctc     3225

ccgttccccg tgcctacaca gggtgctggc tctggcagaa agacagtgtg cccgccccgc     3285

atcacctgtc cgagtgcgaa caccttggga agggggttcc tggtggtcct gtgacaacca     3345

gagaccccca gggccaaggt gaggcgccca cccctggtcc ctcaataaag aactgcaagc     3405

acatgctggt cctggggagt cgggcaggca cggagctagc tgcaagcatc cgtcttcccc     3465

caggaggcca ctgcagcccg gcccttctgt gccctgggcc cctcctcatt gcagcaccac     3525

ccaccgcacc accctgggac agaggaaaca catggaggcc atagcataga gcctgtctgt     3585

ttatagatct ctgcctgtct tgtccgtcca tccactgtgt gtatatatct gtgtatctct     3645

gtggagcggg gaacgggaca gttgtgtaaa aatccaaaat acaattctga ctatgaacaa     3705

aaaaaaaaaa aaa                                                        3718


<210>  548
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  548

Met Gly Asp Arg Gly Ser Ser Arg Arg Arg Arg Thr Gly Ser Arg Pro 
1               5                   10                  15      


Ser Ser His Gly Gly Gly Gly Pro Ala Ala Ala Glu Glu Glu Val Arg 
            20                  25                  30          


Asp Ala Ala Ala Gly Pro Asp Val Gly Ala Ala Gly Asp Ala Pro Ala 
        35                  40                  45              


Pro Ala Pro Asn Lys Asp Gly Asp Ala Gly Val Gly Ser Gly His Trp 
    50                  55                  60                  


Glu Leu Arg Cys His Arg Leu Gln Asp Ser Leu Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Gly Phe Ser Asn Tyr Arg Gly Ile Leu Asn Trp Cys Val Val Met Leu 
                85                  90                  95      


Ile Leu Ser Asn Ala Arg Leu Phe Leu Glu Asn Leu Ile Lys Tyr Gly 
            100                 105                 110         


Ile Leu Val Asp Pro Ile Gln Val Val Ser Leu Phe Leu Lys Asp Pro 
        115                 120                 125             


Tyr Ser Trp Pro Ala Pro Cys Leu Val Ile Ala Ala Asn Val Phe Ala 
    130                 135                 140                 


Val Ala Ala Phe Gln Val Glu Lys Arg Leu Ala Val Gly Ala Leu Thr 
145                 150                 155                 160 


Glu Gln Ala Gly Leu Leu Leu His Val Ala Asn Leu Ala Thr Ile Leu 
                165                 170                 175     


Cys Phe Pro Ala Ala Val Val Leu Leu Val Glu Ser Ile Thr Pro Val 
            180                 185                 190         


Gly Ser Leu Leu Ala Leu Met Ala His Thr Ile Leu Phe Leu Lys Leu 
        195                 200                 205             


Phe Ser Tyr Arg Asp Val Asn Ser Trp Cys Arg Arg Ala Arg Ala Lys 
    210                 215                 220                 


Ala Ala Ser Ala Gly Lys Lys Ala Ser Ser Ala Ala Ala Pro His Thr 
225                 230                 235                 240 


Val Ser Tyr Pro Asp Asn Leu Thr Tyr Arg Asp Leu Tyr Tyr Phe Leu 
                245                 250                 255     


Phe Ala Pro Thr Leu Cys Tyr Glu Leu Asn Phe Pro Arg Ser Pro Arg 
            260                 265                 270         


Ile Arg Lys Arg Phe Leu Leu Arg Arg Ile Leu Glu Met Leu Phe Phe 
        275                 280                 285             


Thr Gln Leu Gln Val Gly Leu Ile Gln Gln Trp Met Val Pro Thr Ile 
    290                 295                 300                 


Gln Asn Ser Met Lys Pro Phe Lys Asp Met Asp Tyr Ser Arg Ile Ile 
305                 310                 315                 320 


Glu Arg Leu Leu Lys Leu Ala Val Pro Asn His Leu Ile Trp Leu Ile 
                325                 330                 335     


Phe Phe Tyr Trp Leu Phe His Ser Cys Leu Asn Ala Val Ala Glu Leu 
            340                 345                 350         


Met Gln Phe Gly Asp Arg Glu Phe Tyr Arg Asp Trp Trp Asn Ser Glu 
        355                 360                 365             


Ser Val Thr Tyr Phe Trp Gln Asn Trp Asn Ile Pro Val His Lys Trp 
    370                 375                 380                 


Cys Ile Arg His Phe Tyr Lys Pro Met Leu Arg Arg Gly Ser Ser Lys 
385                 390                 395                 400 


Trp Met Ala Arg Thr Gly Val Phe Leu Ala Ser Ala Phe Phe His Glu 
                405                 410                 415     


Tyr Leu Val Ser Val Pro Leu Arg Met Phe Arg Leu Trp Ala Phe Thr 
            420                 425                 430         


Gly Met Met Ala Gln Ile Pro Leu Ala Trp Phe Val Gly Arg Phe Phe 
        435                 440                 445             


Gln Gly Asn Tyr Gly Asn Ala Ala Val Trp Leu Ser Leu Ile Ile Gly 
    450                 455                 460                 


Gln Pro Ile Ala Val Leu Met Tyr Val His Asp Tyr Tyr Val Leu Asn 
465                 470                 475                 480 


Tyr Glu Ala Pro Ala Ala Glu Ala 
                485             


<210>  549
<211>  3083
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (59)..(2722)

<400>  549
atgttgtttt tcctgtacct aagttcccgc tgtaggtggt acctttgcag acggtgcg         58

atg ggg gaa gca gag aag ttt cac tac atc tat agt tgt gac ctg gat        106
Met Gly Glu Ala Glu Lys Phe His Tyr Ile Tyr Ser Cys Asp Leu Asp           
1               5                   10                  15                

atc aac gtc cag ctt aag ata gga agc ttg gaa ggg aag aga gaa caa        154
Ile Asn Val Gln Leu Lys Ile Gly Ser Leu Glu Gly Lys Arg Glu Gln           
            20                  25                  30                    

aag agt tat aaa gct gtc ctg gaa gac cca atg ttg aag ttc tca gga        202
Lys Ser Tyr Lys Ala Val Leu Glu Asp Pro Met Leu Lys Phe Ser Gly           
        35                  40                  45                        

cta tat caa gag aca tgc tct gat ctt tat gtt act tgt caa gtt ttt        250
Leu Tyr Gln Glu Thr Cys Ser Asp Leu Tyr Val Thr Cys Gln Val Phe           
    50                  55                  60                            

gca gaa ggg aag cct ttg gcc ttg cca gtg aga aca tcc tac aaa gca        298
Ala Glu Gly Lys Pro Leu Ala Leu Pro Val Arg Thr Ser Tyr Lys Ala           
65                  70                  75                  80            

ttt agt aca aga tgg aac tgg aat gaa tgg ctg aaa cta cca gta aaa        346
Phe Ser Thr Arg Trp Asn Trp Asn Glu Trp Leu Lys Leu Pro Val Lys           
                85                  90                  95                

tac cct gac ctg ccc agg aat gcc caa gtg gcc ctc acc ata tgg gat        394
Tyr Pro Asp Leu Pro Arg Asn Ala Gln Val Ala Leu Thr Ile Trp Asp           
            100                 105                 110                   

gtg tat ggt ccc gga aaa gca gtg cct gta gga gga aca acg gtt tcg        442
Val Tyr Gly Pro Gly Lys Ala Val Pro Val Gly Gly Thr Thr Val Ser           
        115                 120                 125                       

ctc ttt gga aaa tac ggc atg ttt cgc caa ggg atg cat gac ttg aaa        490
Leu Phe Gly Lys Tyr Gly Met Phe Arg Gln Gly Met His Asp Leu Lys           
    130                 135                 140                           

gtc tgg cct aat gta gaa gca gat gga tca gaa ccc aca aaa act cct        538
Val Trp Pro Asn Val Glu Ala Asp Gly Ser Glu Pro Thr Lys Thr Pro           
145                 150                 155                 160           

ggc aga aca agt agc act ctc tca gaa gat cag atg agc cgt ctt gcc        586
Gly Arg Thr Ser Ser Thr Leu Ser Glu Asp Gln Met Ser Arg Leu Ala           
                165                 170                 175               

aag ctc acc aaa gct cat cga caa gga cac atg gtg aaa gta gat tgg        634
Lys Leu Thr Lys Ala His Arg Gln Gly His Met Val Lys Val Asp Trp           
            180                 185                 190                   

ctg gat aga ttg aca ttt aga gaa ata gaa atg ata aat gag agt gaa        682
Leu Asp Arg Leu Thr Phe Arg Glu Ile Glu Met Ile Asn Glu Ser Glu           
        195                 200                 205                       

aaa cga agt tct aat ttc atg tac ctg atg gtt gaa ttt cga tgt gtc        730
Lys Arg Ser Ser Asn Phe Met Tyr Leu Met Val Glu Phe Arg Cys Val           
    210                 215                 220                           

aag tgt gat gat aag gaa tat ggt att gtt tat tat gaa aag gac ggt        778
Lys Cys Asp Asp Lys Glu Tyr Gly Ile Val Tyr Tyr Glu Lys Asp Gly           
225                 230                 235                 240           

gat gaa tca tct cca att tta aca agt ttt gaa tta gtg aaa gtt cct        826
Asp Glu Ser Ser Pro Ile Leu Thr Ser Phe Glu Leu Val Lys Val Pro           
                245                 250                 255               

gac ccc cag atg tct atg gag aat tta gtt gag agc aaa cac cac aag        874
Asp Pro Gln Met Ser Met Glu Asn Leu Val Glu Ser Lys His His Lys           
            260                 265                 270                   

ctt gcc cgg agt tta aga agt gga cct tct gac cac gat ctg aaa ccc        922
Leu Ala Arg Ser Leu Arg Ser Gly Pro Ser Asp His Asp Leu Lys Pro           
        275                 280                 285                       

aat gct gcc acg aga gat cag tta aat att att gtg agt tat cca cca        970
Asn Ala Ala Thr Arg Asp Gln Leu Asn Ile Ile Val Ser Tyr Pro Pro           
    290                 295                 300                           

acc aag caa ctt aca tat gaa gaa caa gat ctt gtt tgg aag ttt aga       1018
Thr Lys Gln Leu Thr Tyr Glu Glu Gln Asp Leu Val Trp Lys Phe Arg           
305                 310                 315                 320           

tat tat ctt acg aat caa gaa aaa gcc ttg aca aaa ttc ttg aaa tgt       1066
Tyr Tyr Leu Thr Asn Gln Glu Lys Ala Leu Thr Lys Phe Leu Lys Cys           
                325                 330                 335               

gtt aat tgg gat cta cct caa gag gcc aaa cag gcc ttg gaa ctt ctg       1114
Val Asn Trp Asp Leu Pro Gln Glu Ala Lys Gln Ala Leu Glu Leu Leu           
            340                 345                 350                   

gga aaa tgg aag ccg atg gat gta gag gac tcc ttg gag ctg tta tcc       1162
Gly Lys Trp Lys Pro Met Asp Val Glu Asp Ser Leu Glu Leu Leu Ser           
        355                 360                 365                       

tct cat tac acc aac cca act gtg agg cgt tat gct gtt gcc cgg ttg       1210
Ser His Tyr Thr Asn Pro Thr Val Arg Arg Tyr Ala Val Ala Arg Leu           
    370                 375                 380                           

cga cag gcc gat gat gag gat ttg ttg atg tac cta tta caa ttg gtc       1258
Arg Gln Ala Asp Asp Glu Asp Leu Leu Met Tyr Leu Leu Gln Leu Val           
385                 390                 395                 400           

cag gct ctc aaa tat gaa aat ttt gat gat ata aag aat gga ttg gaa       1306
Gln Ala Leu Lys Tyr Glu Asn Phe Asp Asp Ile Lys Asn Gly Leu Glu           
                405                 410                 415               

cct acc aag aag gat agt cag agt tca gtg tca gaa aat gtg tca aat       1354
Pro Thr Lys Lys Asp Ser Gln Ser Ser Val Ser Glu Asn Val Ser Asn           
            420                 425                 430                   

tct gga ata aat tct gca gaa ata gat agc tcc caa att ata acc agc       1402
Ser Gly Ile Asn Ser Ala Glu Ile Asp Ser Ser Gln Ile Ile Thr Ser           
        435                 440                 445                       

ccc ctt cct tca gtc tct tca cct cct cct gca tca aaa aca aaa gaa       1450
Pro Leu Pro Ser Val Ser Ser Pro Pro Pro Ala Ser Lys Thr Lys Glu           
    450                 455                 460                           

gtt cca gat ggc gaa aat ctg gaa caa gat ctc tgt acc ttc ttg ata       1498
Val Pro Asp Gly Glu Asn Leu Glu Gln Asp Leu Cys Thr Phe Leu Ile           
465                 470                 475                 480           

tcg aga gcc tgc aaa aac tca aca ctg gct aat tat tta tac tgg tat       1546
Ser Arg Ala Cys Lys Asn Ser Thr Leu Ala Asn Tyr Leu Tyr Trp Tyr           
                485                 490                 495               

gtg ata gtg gaa tgt gaa gat caa gat act cag cag aga gat cca aag       1594
Val Ile Val Glu Cys Glu Asp Gln Asp Thr Gln Gln Arg Asp Pro Lys           
            500                 505                 510                   

acc cat gag atg tac ttg aac gta atg aga aga ttc agc caa gca ttg       1642
Thr His Glu Met Tyr Leu Asn Val Met Arg Arg Phe Ser Gln Ala Leu           
        515                 520                 525                       

ttg aag ggt gat aag tct gtc aga gtt atg cgt tct ttg ctg gct gca       1690
Leu Lys Gly Asp Lys Ser Val Arg Val Met Arg Ser Leu Leu Ala Ala           
    530                 535                 540                           

caa cag aca ttt gta gat cgg ttg gtg cat cta atg aag gca gta caa       1738
Gln Gln Thr Phe Val Asp Arg Leu Val His Leu Met Lys Ala Val Gln           
545                 550                 555                 560           

cgc gaa agt gga aat cgt aag aaa aag aat gag aga cta cag gca ttg       1786
Arg Glu Ser Gly Asn Arg Lys Lys Lys Asn Glu Arg Leu Gln Ala Leu           
                565                 570                 575               

ctt gga gat aat gaa aag atg aat ttg tca gat gtg gaa ctt atc ccg       1834
Leu Gly Asp Asn Glu Lys Met Asn Leu Ser Asp Val Glu Leu Ile Pro           
            580                 585                 590                   

ttg cct tta gaa ccc caa gtg aaa att aga gga ata att ccg gaa aca       1882
Leu Pro Leu Glu Pro Gln Val Lys Ile Arg Gly Ile Ile Pro Glu Thr           
        595                 600                 605                       

gct aca ctg ttt aaa agt gcc ctt atg cct gca cag ttg ttt ttt aag       1930
Ala Thr Leu Phe Lys Ser Ala Leu Met Pro Ala Gln Leu Phe Phe Lys           
    610                 615                 620                           

acg gaa gat gga ggc aaa tat cca gtt ata ttt aag cat gga gat gat       1978
Thr Glu Asp Gly Gly Lys Tyr Pro Val Ile Phe Lys His Gly Asp Asp           
625                 630                 635                 640           

tta cgt caa gat caa ctt att ctt caa atc att tca ctc atg gac aag       2026
Leu Arg Gln Asp Gln Leu Ile Leu Gln Ile Ile Ser Leu Met Asp Lys           
                645                 650                 655               

ctg tta cgg aaa gaa aat ctg gac ttg aaa ttg aca cct tat aag gtg       2074
Leu Leu Arg Lys Glu Asn Leu Asp Leu Lys Leu Thr Pro Tyr Lys Val           
            660                 665                 670                   

tta gcc acc agt aca aaa cat ggc ttc atg cag ttt atc cag tca gtt       2122
Leu Ala Thr Ser Thr Lys His Gly Phe Met Gln Phe Ile Gln Ser Val           
        675                 680                 685                       

cct gtg gct gaa gtt ctt gat aca gag gga agc att cag aac ttt ttt       2170
Pro Val Ala Glu Val Leu Asp Thr Glu Gly Ser Ile Gln Asn Phe Phe           
    690                 695                 700                           

aga aaa tat gca cca agt gag aat ggg cca aat ggg att agt gct gag       2218
Arg Lys Tyr Ala Pro Ser Glu Asn Gly Pro Asn Gly Ile Ser Ala Glu           
705                 710                 715                 720           

gtc atg gac act tac gtt aaa agc tgt gct gga tat tgc gtg atc acc       2266
Val Met Asp Thr Tyr Val Lys Ser Cys Ala Gly Tyr Cys Val Ile Thr           
                725                 730                 735               

tat ata ctt gga gtt gga gac agg cac ctg gat aac ctt ttg cta aca       2314
Tyr Ile Leu Gly Val Gly Asp Arg His Leu Asp Asn Leu Leu Leu Thr           
            740                 745                 750                   

aaa aca ggc aaa ctc ttc cac ata gac ttt gga tat att ttg ggt cgg       2362
Lys Thr Gly Lys Leu Phe His Ile Asp Phe Gly Tyr Ile Leu Gly Arg           
        755                 760                 765                       

gat cca aag cct ctt cct cca cca atg aag ctg aat aaa gaa atg gta       2410
Asp Pro Lys Pro Leu Pro Pro Pro Met Lys Leu Asn Lys Glu Met Val           
    770                 775                 780                           

gaa gga atg ggg ggc aca cag agt gag cag tac caa gag ttc cgt aaa       2458
Glu Gly Met Gly Gly Thr Gln Ser Glu Gln Tyr Gln Glu Phe Arg Lys           
785                 790                 795                 800           

cag tgt tac acg gct ttc ctc cac ctg cga agg tat tct aat ctg att       2506
Gln Cys Tyr Thr Ala Phe Leu His Leu Arg Arg Tyr Ser Asn Leu Ile           
                805                 810                 815               

ttg aac ttg ttt tcc ttg atg gtt gat gca aac att cca gat att gca       2554
Leu Asn Leu Phe Ser Leu Met Val Asp Ala Asn Ile Pro Asp Ile Ala           
            820                 825                 830                   

ctt gaa cca gat aaa act gtg aaa aag gtt cag gat aaa ttc cgc tta       2602
Leu Glu Pro Asp Lys Thr Val Lys Lys Val Gln Asp Lys Phe Arg Leu           
        835                 840                 845                       

gac ctg tcg gat gaa gag gct gtg cat tac atg cag agt ctg att gat       2650
Asp Leu Ser Asp Glu Glu Ala Val His Tyr Met Gln Ser Leu Ile Asp           
    850                 855                 860                           

gag agt gtc cat gct ctt ttt gct gca gtg gtg gaa cag att cac aag       2698
Glu Ser Val His Ala Leu Phe Ala Ala Val Val Glu Gln Ile His Lys           
865                 870                 875                 880           

ttt gcc cag tac tgg aga aaa tga aactgggatt gacccatcaa gatgcttggc      2752
Phe Ala Gln Tyr Trp Arg Lys                                               
                885                                                       

tcaataagaa aaccacgtta ggagcaacct ttgtatattg gagacttcag agtaaccagc     2812

aaggaagaga aatcttaatc ttcaagttac catattttcc aaatattaca tggtacctga     2872

gttctgcttc cttggatgtc attgcttaaa tatagtcttg aagggcttgt tttgaaatat     2932

tgtatatatt ttttcaaatg tatacattgt taataaatta agaaatgaga aacattctta     2992

tttatgtaca tgttatgaga gttctggagg aagtaatatg ttgaaatagt aaaacatttt     3052

agtttttgag tttaaaaaaa aaaaaaaaaa a                                    3083


<210>  550
<211>  887
<212>  PRT
<213>  Homo sapiens

<400>  550

Met Gly Glu Ala Glu Lys Phe His Tyr Ile Tyr Ser Cys Asp Leu Asp 
1               5                   10                  15      


Ile Asn Val Gln Leu Lys Ile Gly Ser Leu Glu Gly Lys Arg Glu Gln 
            20                  25                  30          


Lys Ser Tyr Lys Ala Val Leu Glu Asp Pro Met Leu Lys Phe Ser Gly 
        35                  40                  45              


Leu Tyr Gln Glu Thr Cys Ser Asp Leu Tyr Val Thr Cys Gln Val Phe 
    50                  55                  60                  


Ala Glu Gly Lys Pro Leu Ala Leu Pro Val Arg Thr Ser Tyr Lys Ala 
65                  70                  75                  80  


Phe Ser Thr Arg Trp Asn Trp Asn Glu Trp Leu Lys Leu Pro Val Lys 
                85                  90                  95      


Tyr Pro Asp Leu Pro Arg Asn Ala Gln Val Ala Leu Thr Ile Trp Asp 
            100                 105                 110         


Val Tyr Gly Pro Gly Lys Ala Val Pro Val Gly Gly Thr Thr Val Ser 
        115                 120                 125             


Leu Phe Gly Lys Tyr Gly Met Phe Arg Gln Gly Met His Asp Leu Lys 
    130                 135                 140                 


Val Trp Pro Asn Val Glu Ala Asp Gly Ser Glu Pro Thr Lys Thr Pro 
145                 150                 155                 160 


Gly Arg Thr Ser Ser Thr Leu Ser Glu Asp Gln Met Ser Arg Leu Ala 
                165                 170                 175     


Lys Leu Thr Lys Ala His Arg Gln Gly His Met Val Lys Val Asp Trp 
            180                 185                 190         


Leu Asp Arg Leu Thr Phe Arg Glu Ile Glu Met Ile Asn Glu Ser Glu 
        195                 200                 205             


Lys Arg Ser Ser Asn Phe Met Tyr Leu Met Val Glu Phe Arg Cys Val 
    210                 215                 220                 


Lys Cys Asp Asp Lys Glu Tyr Gly Ile Val Tyr Tyr Glu Lys Asp Gly 
225                 230                 235                 240 


Asp Glu Ser Ser Pro Ile Leu Thr Ser Phe Glu Leu Val Lys Val Pro 
                245                 250                 255     


Asp Pro Gln Met Ser Met Glu Asn Leu Val Glu Ser Lys His His Lys 
            260                 265                 270         


Leu Ala Arg Ser Leu Arg Ser Gly Pro Ser Asp His Asp Leu Lys Pro 
        275                 280                 285             


Asn Ala Ala Thr Arg Asp Gln Leu Asn Ile Ile Val Ser Tyr Pro Pro 
    290                 295                 300                 


Thr Lys Gln Leu Thr Tyr Glu Glu Gln Asp Leu Val Trp Lys Phe Arg 
305                 310                 315                 320 


Tyr Tyr Leu Thr Asn Gln Glu Lys Ala Leu Thr Lys Phe Leu Lys Cys 
                325                 330                 335     


Val Asn Trp Asp Leu Pro Gln Glu Ala Lys Gln Ala Leu Glu Leu Leu 
            340                 345                 350         


Gly Lys Trp Lys Pro Met Asp Val Glu Asp Ser Leu Glu Leu Leu Ser 
        355                 360                 365             


Ser His Tyr Thr Asn Pro Thr Val Arg Arg Tyr Ala Val Ala Arg Leu 
    370                 375                 380                 


Arg Gln Ala Asp Asp Glu Asp Leu Leu Met Tyr Leu Leu Gln Leu Val 
385                 390                 395                 400 


Gln Ala Leu Lys Tyr Glu Asn Phe Asp Asp Ile Lys Asn Gly Leu Glu 
                405                 410                 415     


Pro Thr Lys Lys Asp Ser Gln Ser Ser Val Ser Glu Asn Val Ser Asn 
            420                 425                 430         


Ser Gly Ile Asn Ser Ala Glu Ile Asp Ser Ser Gln Ile Ile Thr Ser 
        435                 440                 445             


Pro Leu Pro Ser Val Ser Ser Pro Pro Pro Ala Ser Lys Thr Lys Glu 
    450                 455                 460                 


Val Pro Asp Gly Glu Asn Leu Glu Gln Asp Leu Cys Thr Phe Leu Ile 
465                 470                 475                 480 


Ser Arg Ala Cys Lys Asn Ser Thr Leu Ala Asn Tyr Leu Tyr Trp Tyr 
                485                 490                 495     


Val Ile Val Glu Cys Glu Asp Gln Asp Thr Gln Gln Arg Asp Pro Lys 
            500                 505                 510         


Thr His Glu Met Tyr Leu Asn Val Met Arg Arg Phe Ser Gln Ala Leu 
        515                 520                 525             


Leu Lys Gly Asp Lys Ser Val Arg Val Met Arg Ser Leu Leu Ala Ala 
    530                 535                 540                 


Gln Gln Thr Phe Val Asp Arg Leu Val His Leu Met Lys Ala Val Gln 
545                 550                 555                 560 


Arg Glu Ser Gly Asn Arg Lys Lys Lys Asn Glu Arg Leu Gln Ala Leu 
                565                 570                 575     


Leu Gly Asp Asn Glu Lys Met Asn Leu Ser Asp Val Glu Leu Ile Pro 
            580                 585                 590         


Leu Pro Leu Glu Pro Gln Val Lys Ile Arg Gly Ile Ile Pro Glu Thr 
        595                 600                 605             


Ala Thr Leu Phe Lys Ser Ala Leu Met Pro Ala Gln Leu Phe Phe Lys 
    610                 615                 620                 


Thr Glu Asp Gly Gly Lys Tyr Pro Val Ile Phe Lys His Gly Asp Asp 
625                 630                 635                 640 


Leu Arg Gln Asp Gln Leu Ile Leu Gln Ile Ile Ser Leu Met Asp Lys 
                645                 650                 655     


Leu Leu Arg Lys Glu Asn Leu Asp Leu Lys Leu Thr Pro Tyr Lys Val 
            660                 665                 670         


Leu Ala Thr Ser Thr Lys His Gly Phe Met Gln Phe Ile Gln Ser Val 
        675                 680                 685             


Pro Val Ala Glu Val Leu Asp Thr Glu Gly Ser Ile Gln Asn Phe Phe 
    690                 695                 700                 


Arg Lys Tyr Ala Pro Ser Glu Asn Gly Pro Asn Gly Ile Ser Ala Glu 
705                 710                 715                 720 


Val Met Asp Thr Tyr Val Lys Ser Cys Ala Gly Tyr Cys Val Ile Thr 
                725                 730                 735     


Tyr Ile Leu Gly Val Gly Asp Arg His Leu Asp Asn Leu Leu Leu Thr 
            740                 745                 750         


Lys Thr Gly Lys Leu Phe His Ile Asp Phe Gly Tyr Ile Leu Gly Arg 
        755                 760                 765             


Asp Pro Lys Pro Leu Pro Pro Pro Met Lys Leu Asn Lys Glu Met Val 
    770                 775                 780                 


Glu Gly Met Gly Gly Thr Gln Ser Glu Gln Tyr Gln Glu Phe Arg Lys 
785                 790                 795                 800 


Gln Cys Tyr Thr Ala Phe Leu His Leu Arg Arg Tyr Ser Asn Leu Ile 
                805                 810                 815     


Leu Asn Leu Phe Ser Leu Met Val Asp Ala Asn Ile Pro Asp Ile Ala 
            820                 825                 830         


Leu Glu Pro Asp Lys Thr Val Lys Lys Val Gln Asp Lys Phe Arg Leu 
        835                 840                 845             


Asp Leu Ser Asp Glu Glu Ala Val His Tyr Met Gln Ser Leu Ile Asp 
    850                 855                 860                 


Glu Ser Val His Ala Leu Phe Ala Ala Val Val Glu Gln Ile His Lys 
865                 870                 875                 880 


Phe Ala Gln Tyr Trp Arg Lys 
                885         


<210>  551
<211>  3448
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (312)..(2228)

<400>  551
gtccgcgcgc ctcgctgcga tggcggcggc gccgagcaca gtcaccccgc tggcggcgga       60

gtcttcccct caggaagcta ccgtctctgc cgcctcctcc tcctcctaca ccgcctgcgc      120

ggcagcggcg gcggcggcgg cggcggcggc agtaattgtt cctgcctcct ccgccacctc      180

cgcccctgcc tgcccgcctg ccggtggctg tggcgacggc ggcggcggcg gctttggcgg      240

ctccactatg gcggcggcgg ggaggggggg cagtagtttt aaagtagaca cccgcccttg      300

cctcagagaa g atg gag tct tgc tct gtc acc agg ctg gag tgc agt ggc       350
             Met Glu Ser Cys Ser Val Thr Arg Leu Glu Cys Ser Gly          
             1               5                   10                       

gca atc tcg gct cac tgc agc ctc cac ctc ccg ggt tca agc gac tcc        398
Ala Ile Ser Ala His Cys Ser Leu His Leu Pro Gly Ser Ser Asp Ser           
    15                  20                  25                            

cct gcc tca gcc tcc caa ata gct ggg act aca gac gcc att tgg aat        446
Pro Ala Ser Ala Ser Gln Ile Ala Gly Thr Thr Asp Ala Ile Trp Asn           
30                  35                  40                  45            

gaa cag gaa aag gct gaa ctt ttt aca gat aag ttt tgt caa gta tgt        494
Glu Gln Glu Lys Ala Glu Leu Phe Thr Asp Lys Phe Cys Gln Val Cys           
                50                  55                  60                

gga gtg atg cta cag ttt gaa tca caa aga att tca cat tat gag ggt        542
Gly Val Met Leu Gln Phe Glu Ser Gln Arg Ile Ser His Tyr Glu Gly           
            65                  70                  75                    

gaa aaa cat gct caa aat gtt agt ttt tat ttt caa atg cat ggg gaa        590
Glu Lys His Ala Gln Asn Val Ser Phe Tyr Phe Gln Met His Gly Glu           
        80                  85                  90                        

caa aat gaa gtg cct ggt aag aaa atg aag atg cat gtt gag aat ttt        638
Gln Asn Glu Val Pro Gly Lys Lys Met Lys Met His Val Glu Asn Phe           
    95                  100                 105                           

cag gtg cat agg tat gaa gga gtg gac aaa aac aaa ttt tgt gat ctc        686
Gln Val His Arg Tyr Glu Gly Val Asp Lys Asn Lys Phe Cys Asp Leu           
110                 115                 120                 125           

tgc aac atg atg ttt agc tct cca ctt att gct cag tct cac tat gtg        734
Cys Asn Met Met Phe Ser Ser Pro Leu Ile Ala Gln Ser His Tyr Val           
                130                 135                 140               

gga aag gtc cat gct aaa aaa ctg aag caa tta atg gag gaa cat gat        782
Gly Lys Val His Ala Lys Lys Leu Lys Gln Leu Met Glu Glu His Asp           
            145                 150                 155                   

cag gca tct cca tca gga ttt caa cca gag atg gca ttt agt atg aga        830
Gln Ala Ser Pro Ser Gly Phe Gln Pro Glu Met Ala Phe Ser Met Arg           
        160                 165                 170                       

acc tat gtt tgc cat att tgt agt att gct ttt aca tct tta gat atg        878
Thr Tyr Val Cys His Ile Cys Ser Ile Ala Phe Thr Ser Leu Asp Met           
    175                 180                 185                           

ttc cgg tcc cac atg caa gga agt gaa cat caa att aaa gaa tcc att        926
Phe Arg Ser His Met Gln Gly Ser Glu His Gln Ile Lys Glu Ser Ile           
190                 195                 200                 205           

gtt atc aat cta gtg aag aat tca agg aag aca caa gac tct tac caa        974
Val Ile Asn Leu Val Lys Asn Ser Arg Lys Thr Gln Asp Ser Tyr Gln           
                210                 215                 220               

aat gag tgt gca gat tac atc aat gtg cag aaa gcc aga gga cta gag       1022
Asn Glu Cys Ala Asp Tyr Ile Asn Val Gln Lys Ala Arg Gly Leu Glu           
            225                 230                 235                   

gcc aag act tgt ttc aga aag atg gaa gag agt tct ttg gaa acc cgt       1070
Ala Lys Thr Cys Phe Arg Lys Met Glu Glu Ser Ser Leu Glu Thr Arg           
        240                 245                 250                       

aga tac aga gaa gtg gtc gat tcc aga ccc aga cat aga atg ttt gaa       1118
Arg Tyr Arg Glu Val Val Asp Ser Arg Pro Arg His Arg Met Phe Glu           
    255                 260                 265                           

caa aga ctc cca ttt gag act ttc cgg aca tac gca gca cca tac aat       1166
Gln Arg Leu Pro Phe Glu Thr Phe Arg Thr Tyr Ala Ala Pro Tyr Asn           
270                 275                 280                 285           

att tca caa gca atg gaa aag cag tta cct cat tca aag aag aca tat       1214
Ile Ser Gln Ala Met Glu Lys Gln Leu Pro His Ser Lys Lys Thr Tyr           
                290                 295                 300               

gac tct ttc caa gat gaa ctt gaa gat tac atc aaa gta cag aaa gcc       1262
Asp Ser Phe Gln Asp Glu Leu Glu Asp Tyr Ile Lys Val Gln Lys Ala           
            305                 310                 315                   

aga gga cta gat cca aag act tgt ttc aga aag atg aga gag aac tct       1310
Arg Gly Leu Asp Pro Lys Thr Cys Phe Arg Lys Met Arg Glu Asn Ser           
        320                 325                 330                       

gtg gat act cat ggg tac aga gaa atg gtt gat tct gga ccc aga tca       1358
Val Asp Thr His Gly Tyr Arg Glu Met Val Asp Ser Gly Pro Arg Ser           
    335                 340                 345                           

aga atg tgt gag caa aga ttt tca cat gag gct tcc cag acc tac caa       1406
Arg Met Cys Glu Gln Arg Phe Ser His Glu Ala Ser Gln Thr Tyr Gln           
350                 355                 360                 365           

cga cca tac cat att tca cca gtg gaa agc cag tta cct cag tgg cta       1454
Arg Pro Tyr His Ile Ser Pro Val Glu Ser Gln Leu Pro Gln Trp Leu           
                370                 375                 380               

cca acc cat tca aag agg aca tat gat tct ttc caa gat gaa ctt gaa       1502
Pro Thr His Ser Lys Arg Thr Tyr Asp Ser Phe Gln Asp Glu Leu Glu           
            385                 390                 395                   

gat tac ata aaa gtg cag aaa gcc aga gga cta gag cca aaa act tgt       1550
Asp Tyr Ile Lys Val Gln Lys Ala Arg Gly Leu Glu Pro Lys Thr Cys           
        400                 405                 410                       

ttc aga aag ata gga gat agc tct gta gaa aca cac agg aac aga gaa       1598
Phe Arg Lys Ile Gly Asp Ser Ser Val Glu Thr His Arg Asn Arg Glu           
    415                 420                 425                           

atg gtt gat gtc aga ccc aga cat aga atg ttg gag caa aag ctc cca       1646
Met Val Asp Val Arg Pro Arg His Arg Met Leu Glu Gln Lys Leu Pro           
430                 435                 440                 445           

tgt gag act ttc cag acc tat tca gga cca tat agt att tca caa gta       1694
Cys Glu Thr Phe Gln Thr Tyr Ser Gly Pro Tyr Ser Ile Ser Gln Val           
                450                 455                 460               

gtg gaa aac cag tta cct cat tgc tta cca gct cat gat agc aaa cag       1742
Val Glu Asn Gln Leu Pro His Cys Leu Pro Ala His Asp Ser Lys Gln           
            465                 470                 475                   

aga cta gat tct att agc tac tgt caa ctc acc aga gac tgt ttc cca       1790
Arg Leu Asp Ser Ile Ser Tyr Cys Gln Leu Thr Arg Asp Cys Phe Pro           
        480                 485                 490                       

gaa aaa cca gta ccc ttg agc ctt aat cag caa gaa aat aac tct ggc       1838
Glu Lys Pro Val Pro Leu Ser Leu Asn Gln Gln Glu Asn Asn Ser Gly           
    495                 500                 505                           

tca tac agt gta gaa tct gaa gtt tac aag cac ctc tct tca gaa aac       1886
Ser Tyr Ser Val Glu Ser Glu Val Tyr Lys His Leu Ser Ser Glu Asn           
510                 515                 520                 525           

aat act gct gac cat caa gca ggt cat aaa cag aaa cat cag aag aga       1934
Asn Thr Ala Asp His Gln Ala Gly His Lys Gln Lys His Gln Lys Arg           
                530                 535                 540               

aaa cga cac cta gaa gaa ggc aaa gaa agg cca gag aaa gag cag tcc       1982
Lys Arg His Leu Glu Glu Gly Lys Glu Arg Pro Glu Lys Glu Gln Ser           
            545                 550                 555                   

aag cat aaa agg aaa aag agt tat gaa gat aca gat tta gac aaa gac       2030
Lys His Lys Arg Lys Lys Ser Tyr Glu Asp Thr Asp Leu Asp Lys Asp           
        560                 565                 570                       

aag agc atc aga caa agg aaa aga gag gag gat aga gtc aag gtc agt       2078
Lys Ser Ile Arg Gln Arg Lys Arg Glu Glu Asp Arg Val Lys Val Ser           
    575                 580                 585                           

tca gga aag ctt aag cat cga aaa aag aaa aaa agc cat gat gta ccc       2126
Ser Gly Lys Leu Lys His Arg Lys Lys Lys Lys Ser His Asp Val Pro           
590                 595                 600                 605           

tcc gag aaa gaa gaa cgt aag cac agg aaa gag aaa aag aaa tct gtt       2174
Ser Glu Lys Glu Glu Arg Lys His Arg Lys Glu Lys Lys Lys Ser Val           
                610                 615                 620               

gaa gaa agg aca gaa gag gaa atg ctt tgg gat gag tct att ctt gga       2222
Glu Glu Arg Thr Glu Glu Glu Met Leu Trp Asp Glu Ser Ile Leu Gly           
            625                 630                 635                   

ttt tga atgtttagtt ttgtttaccc aaggttgaat tgaaaaaaaa aaacagtcaa        2278
Phe                                                                       
                                                                          

tatggattta gaaaaaggaa cacctgatga agaaaaggag aggtagatac agtcagtgtc     2338

acttcaggac acttaggttt tttttgtata aaaatttaaa ttgaattaaa agaaggaaaa     2398

aaaaagccca aacttaacct ctgagaaaag aacataagaa ctcaaggaga acataagaga     2458

aaaggaaacc tgttacagaa aagacaagaa tctgtgtttt ggaatgagtc tattcttggg     2518

tattgaactt ttagttttgt ttgcccaagg attaattgag gaaatcagct aagaaaatgg     2578

actttagaca aaagcaagag gatcagatga agaaaaggag aggtagatac agtcagtgtc     2638

acttcaggaa agctatttaa aaaaacttga aatttaattg aaagaagaaa caacaacaaa     2698

aaagcctaaa cctagcctct gaacaacact aacatgagaa cacaagaact taagagaaaa     2758

agaaacctac tcaagaaaag acagaagaga cagtgatttg ggatgagtct actctaggat     2818

tttcaacttt ttagttttgt tccttcaaag ttgaaggaaa aaaagtttgg ttttataaaa     2878

ttcatgttat tgtaattttt ctaggtggat ggctacttta atctctaaaa aagccaagtg     2938

aagtaaaagt attcagtatg ccttttcctc aagttacttt ccttcatttt cttaaaaaag     2998

aaaaaaaatt attaaatgtt tctcacatat ctcacatata atgtaatttc cctaaatgaa     3058

gttgtctcta cttctgctca tcaaattgct gtgatagtga attatttatt catgggagat     3118

aatttatttt aaaggacaga attaccaagc gttacaaaat cagttctttc cttggttttg     3178

tgttagtgtt ggtggtattt tattgttgtt tttctgtgtt tatgtgtctc agctttctcc     3238

aaggaatatg tatgaaataa cttaaactga ttttttcttt gttaaatcta atttgcagtg     3298

tatttttgca ttttctagtt ctgaaagtgg aaaatgaaac agtctataat aaacttagat     3358

gatatatagt tttaaaacgg tctcaaaaag tactgatata aggtcagtct atattctgga     3418

aatgtttata ttaaagtgtt ttaatttcta                                      3448


<210>  552
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  552

Met Glu Ser Cys Ser Val Thr Arg Leu Glu Cys Ser Gly Ala Ile Ser 
1               5                   10                  15      


Ala His Cys Ser Leu His Leu Pro Gly Ser Ser Asp Ser Pro Ala Ser 
            20                  25                  30          


Ala Ser Gln Ile Ala Gly Thr Thr Asp Ala Ile Trp Asn Glu Gln Glu 
        35                  40                  45              


Lys Ala Glu Leu Phe Thr Asp Lys Phe Cys Gln Val Cys Gly Val Met 
    50                  55                  60                  


Leu Gln Phe Glu Ser Gln Arg Ile Ser His Tyr Glu Gly Glu Lys His 
65                  70                  75                  80  


Ala Gln Asn Val Ser Phe Tyr Phe Gln Met His Gly Glu Gln Asn Glu 
                85                  90                  95      


Val Pro Gly Lys Lys Met Lys Met His Val Glu Asn Phe Gln Val His 
            100                 105                 110         


Arg Tyr Glu Gly Val Asp Lys Asn Lys Phe Cys Asp Leu Cys Asn Met 
        115                 120                 125             


Met Phe Ser Ser Pro Leu Ile Ala Gln Ser His Tyr Val Gly Lys Val 
    130                 135                 140                 


His Ala Lys Lys Leu Lys Gln Leu Met Glu Glu His Asp Gln Ala Ser 
145                 150                 155                 160 


Pro Ser Gly Phe Gln Pro Glu Met Ala Phe Ser Met Arg Thr Tyr Val 
                165                 170                 175     


Cys His Ile Cys Ser Ile Ala Phe Thr Ser Leu Asp Met Phe Arg Ser 
            180                 185                 190         


His Met Gln Gly Ser Glu His Gln Ile Lys Glu Ser Ile Val Ile Asn 
        195                 200                 205             


Leu Val Lys Asn Ser Arg Lys Thr Gln Asp Ser Tyr Gln Asn Glu Cys 
    210                 215                 220                 


Ala Asp Tyr Ile Asn Val Gln Lys Ala Arg Gly Leu Glu Ala Lys Thr 
225                 230                 235                 240 


Cys Phe Arg Lys Met Glu Glu Ser Ser Leu Glu Thr Arg Arg Tyr Arg 
                245                 250                 255     


Glu Val Val Asp Ser Arg Pro Arg His Arg Met Phe Glu Gln Arg Leu 
            260                 265                 270         


Pro Phe Glu Thr Phe Arg Thr Tyr Ala Ala Pro Tyr Asn Ile Ser Gln 
        275                 280                 285             


Ala Met Glu Lys Gln Leu Pro His Ser Lys Lys Thr Tyr Asp Ser Phe 
    290                 295                 300                 


Gln Asp Glu Leu Glu Asp Tyr Ile Lys Val Gln Lys Ala Arg Gly Leu 
305                 310                 315                 320 


Asp Pro Lys Thr Cys Phe Arg Lys Met Arg Glu Asn Ser Val Asp Thr 
                325                 330                 335     


His Gly Tyr Arg Glu Met Val Asp Ser Gly Pro Arg Ser Arg Met Cys 
            340                 345                 350         


Glu Gln Arg Phe Ser His Glu Ala Ser Gln Thr Tyr Gln Arg Pro Tyr 
        355                 360                 365             


His Ile Ser Pro Val Glu Ser Gln Leu Pro Gln Trp Leu Pro Thr His 
    370                 375                 380                 


Ser Lys Arg Thr Tyr Asp Ser Phe Gln Asp Glu Leu Glu Asp Tyr Ile 
385                 390                 395                 400 


Lys Val Gln Lys Ala Arg Gly Leu Glu Pro Lys Thr Cys Phe Arg Lys 
                405                 410                 415     


Ile Gly Asp Ser Ser Val Glu Thr His Arg Asn Arg Glu Met Val Asp 
            420                 425                 430         


Val Arg Pro Arg His Arg Met Leu Glu Gln Lys Leu Pro Cys Glu Thr 
        435                 440                 445             


Phe Gln Thr Tyr Ser Gly Pro Tyr Ser Ile Ser Gln Val Val Glu Asn 
    450                 455                 460                 


Gln Leu Pro His Cys Leu Pro Ala His Asp Ser Lys Gln Arg Leu Asp 
465                 470                 475                 480 


Ser Ile Ser Tyr Cys Gln Leu Thr Arg Asp Cys Phe Pro Glu Lys Pro 
                485                 490                 495     


Val Pro Leu Ser Leu Asn Gln Gln Glu Asn Asn Ser Gly Ser Tyr Ser 
            500                 505                 510         


Val Glu Ser Glu Val Tyr Lys His Leu Ser Ser Glu Asn Asn Thr Ala 
        515                 520                 525             


Asp His Gln Ala Gly His Lys Gln Lys His Gln Lys Arg Lys Arg His 
    530                 535                 540                 


Leu Glu Glu Gly Lys Glu Arg Pro Glu Lys Glu Gln Ser Lys His Lys 
545                 550                 555                 560 


Arg Lys Lys Ser Tyr Glu Asp Thr Asp Leu Asp Lys Asp Lys Ser Ile 
                565                 570                 575     


Arg Gln Arg Lys Arg Glu Glu Asp Arg Val Lys Val Ser Ser Gly Lys 
            580                 585                 590         


Leu Lys His Arg Lys Lys Lys Lys Ser His Asp Val Pro Ser Glu Lys 
        595                 600                 605             


Glu Glu Arg Lys His Arg Lys Glu Lys Lys Lys Ser Val Glu Glu Arg 
    610                 615                 620                 


Thr Glu Glu Glu Met Leu Trp Asp Glu Ser Ile Leu Gly Phe 
625                 630                 635             


<210>  553
<211>  1332
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (43)..(1104)

<400>  553
ggggggtctt ggcggccgga ggaggagtag gtgcgggtga ag atg gcg gca gcc          54
                                               Met Ala Ala Ala            
                                               1                          

gag gcc gcg aac tgc atc atg gag gtg tcc tgt ggc cag gcg gaa agc        102
Glu Ala Ala Asn Cys Ile Met Glu Val Ser Cys Gly Gln Ala Glu Ser           
5                   10                  15                  20            

agt gag aag ccc aac gct gag gac atg aca tcc aaa gat tac tac ttt        150
Ser Glu Lys Pro Asn Ala Glu Asp Met Thr Ser Lys Asp Tyr Tyr Phe           
                25                  30                  35                

gac tcc tac gca cac ttt ggc atc cac gag gag atg ctg aag gac gag        198
Asp Ser Tyr Ala His Phe Gly Ile His Glu Glu Met Leu Lys Asp Glu           
            40                  45                  50                    

gtg cgc acc ctc act tac cgc aac tcc atg ttt cat aac cgg cac ctc        246
Val Arg Thr Leu Thr Tyr Arg Asn Ser Met Phe His Asn Arg His Leu           
        55                  60                  65                        

ttc aag gac aag gtg gtg ctg gac gtc ggc tcg ggc acc ggc atc ctc        294
Phe Lys Asp Lys Val Val Leu Asp Val Gly Ser Gly Thr Gly Ile Leu           
    70                  75                  80                            

tgc atg ttt gct gcc aag gcc ggg gcc cgc aag gtc atc ggg atc gag        342
Cys Met Phe Ala Ala Lys Ala Gly Ala Arg Lys Val Ile Gly Ile Glu           
85                  90                  95                  100           

tgt tcc agt atc tct gat tat gcg gtg aag atc gtc aaa gcc aac aag        390
Cys Ser Ser Ile Ser Asp Tyr Ala Val Lys Ile Val Lys Ala Asn Lys           
                105                 110                 115               

tta gac cac gtg gtg acc atc atc aag ggg aag gtg gag gag gtg gag        438
Leu Asp His Val Val Thr Ile Ile Lys Gly Lys Val Glu Glu Val Glu           
            120                 125                 130                   

ctc cca gtg gag aag gtg gac atc atc atc agc gag tgg atg ggc tac        486
Leu Pro Val Glu Lys Val Asp Ile Ile Ile Ser Glu Trp Met Gly Tyr           
        135                 140                 145                       

tgc ctc ttc tac gag tcc atg ctc aac acc gtg ctc tat gcc cgg gac        534
Cys Leu Phe Tyr Glu Ser Met Leu Asn Thr Val Leu Tyr Ala Arg Asp           
    150                 155                 160                           

aag tgg ctg gcg ccc gat ggc ctc atc ttc cca gac cgg gcc acg ctg        582
Lys Trp Leu Ala Pro Asp Gly Leu Ile Phe Pro Asp Arg Ala Thr Leu           
165                 170                 175                 180           

tat gtg acg gcc atc gag gac cgg cag tac aaa gac tac aag atc cac        630
Tyr Val Thr Ala Ile Glu Asp Arg Gln Tyr Lys Asp Tyr Lys Ile His           
                185                 190                 195               

tgg tgg gag aac gtg tat ggc ttc gac atg tct tgc atc aaa gat gtg        678
Trp Trp Glu Asn Val Tyr Gly Phe Asp Met Ser Cys Ile Lys Asp Val           
            200                 205                 210                   

gcc att aag gag ccc cta gtg gat gtc gtg gac ccc aaa cag ctg gtc        726
Ala Ile Lys Glu Pro Leu Val Asp Val Val Asp Pro Lys Gln Leu Val           
        215                 220                 225                       

acc aac gcc tgc ctc ata aag gag gtg gac atc tat acc gtc aag gtg        774
Thr Asn Ala Cys Leu Ile Lys Glu Val Asp Ile Tyr Thr Val Lys Val           
    230                 235                 240                           

gaa gac ctg acc ttc acc tcc ccg ttc tgc ctg caa gtg aag cgg aat        822
Glu Asp Leu Thr Phe Thr Ser Pro Phe Cys Leu Gln Val Lys Arg Asn           
245                 250                 255                 260           

gac tac gtg cac gcc ctg gtg gcc tac ttc aac atc gag ttc aca cgc        870
Asp Tyr Val His Ala Leu Val Ala Tyr Phe Asn Ile Glu Phe Thr Arg           
                265                 270                 275               

tgc cac aag agg acc ggc ttc tcc acc agc ccc gag tcc ccg tac acg        918
Cys His Lys Arg Thr Gly Phe Ser Thr Ser Pro Glu Ser Pro Tyr Thr           
            280                 285                 290                   

cac tgg aag cag acg gtg ttc tac atg gag gac tac ctg acc gtg aag        966
His Trp Lys Gln Thr Val Phe Tyr Met Glu Asp Tyr Leu Thr Val Lys           
        295                 300                 305                       

acg ggc gag gag atc ttc ggc acc atc ggc atg cgg ccc aac gcc aag       1014
Thr Gly Glu Glu Ile Phe Gly Thr Ile Gly Met Arg Pro Asn Ala Lys           
    310                 315                 320                           

aac aac cgg gac ctg gac ttc acc atc gac ctg gac ttc aag ggc cag       1062
Asn Asn Arg Asp Leu Asp Phe Thr Ile Asp Leu Asp Phe Lys Gly Gln           
325                 330                 335                 340           

ctg tgc gag ctg tcc tgc tcc acc gac tac cgg atg cgc tga               1104
Leu Cys Glu Leu Ser Cys Ser Thr Asp Tyr Arg Met Arg                       
                345                 350                                   

ggcccggctc tcccgccctg cacgagccca ggggctgagc gttcctaggc ggtttcgggg     1164

ctcccccttc ctctccctcc ctcccgcaga agggggtttt aggggcctgg gctgggggga     1224

tggggagggc acatcgtgac tgtgtttttc ataacttatg tttttatatg gttgcattta     1284

cgccaataaa tcctcagctg ggaaaaaaaa aaaaaaaaaa aaaaaaaa                  1332


<210>  554
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  554

Met Ala Ala Ala Glu Ala Ala Asn Cys Ile Met Glu Val Ser Cys Gly 
1               5                   10                  15      


Gln Ala Glu Ser Ser Glu Lys Pro Asn Ala Glu Asp Met Thr Ser Lys 
            20                  25                  30          


Asp Tyr Tyr Phe Asp Ser Tyr Ala His Phe Gly Ile His Glu Glu Met 
        35                  40                  45              


Leu Lys Asp Glu Val Arg Thr Leu Thr Tyr Arg Asn Ser Met Phe His 
    50                  55                  60                  


Asn Arg His Leu Phe Lys Asp Lys Val Val Leu Asp Val Gly Ser Gly 
65                  70                  75                  80  


Thr Gly Ile Leu Cys Met Phe Ala Ala Lys Ala Gly Ala Arg Lys Val 
                85                  90                  95      


Ile Gly Ile Glu Cys Ser Ser Ile Ser Asp Tyr Ala Val Lys Ile Val 
            100                 105                 110         


Lys Ala Asn Lys Leu Asp His Val Val Thr Ile Ile Lys Gly Lys Val 
        115                 120                 125             


Glu Glu Val Glu Leu Pro Val Glu Lys Val Asp Ile Ile Ile Ser Glu 
    130                 135                 140                 


Trp Met Gly Tyr Cys Leu Phe Tyr Glu Ser Met Leu Asn Thr Val Leu 
145                 150                 155                 160 


Tyr Ala Arg Asp Lys Trp Leu Ala Pro Asp Gly Leu Ile Phe Pro Asp 
                165                 170                 175     


Arg Ala Thr Leu Tyr Val Thr Ala Ile Glu Asp Arg Gln Tyr Lys Asp 
            180                 185                 190         


Tyr Lys Ile His Trp Trp Glu Asn Val Tyr Gly Phe Asp Met Ser Cys 
        195                 200                 205             


Ile Lys Asp Val Ala Ile Lys Glu Pro Leu Val Asp Val Val Asp Pro 
    210                 215                 220                 


Lys Gln Leu Val Thr Asn Ala Cys Leu Ile Lys Glu Val Asp Ile Tyr 
225                 230                 235                 240 


Thr Val Lys Val Glu Asp Leu Thr Phe Thr Ser Pro Phe Cys Leu Gln 
                245                 250                 255     


Val Lys Arg Asn Asp Tyr Val His Ala Leu Val Ala Tyr Phe Asn Ile 
            260                 265                 270         


Glu Phe Thr Arg Cys His Lys Arg Thr Gly Phe Ser Thr Ser Pro Glu 
        275                 280                 285             


Ser Pro Tyr Thr His Trp Lys Gln Thr Val Phe Tyr Met Glu Asp Tyr 
    290                 295                 300                 


Leu Thr Val Lys Thr Gly Glu Glu Ile Phe Gly Thr Ile Gly Met Arg 
305                 310                 315                 320 


Pro Asn Ala Lys Asn Asn Arg Asp Leu Asp Phe Thr Ile Asp Leu Asp 
                325                 330                 335     


Phe Lys Gly Gln Leu Cys Glu Leu Ser Cys Ser Thr Asp Tyr Arg Met 
            340                 345                 350         


Arg 
    


<210>  555
<211>  3333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (245)..(2269)

<400>  555
ggaacttgca cagtccgcct cgggcagccc aaagctcctc tgcccaccct ggctcccaga       60

gccctccaaa acaaaagacc agagaagcac tctccaccca gcagccagac gcctccttct      120

tgacgccagc ccccaccctc tgtctgctcg agcccaggaa aggcctgaag gaagaggccg      180

gggaaagagc cctccctctc tcccttgtcc ctccatccac ccagcgccgg catctggaga      240

ccct atg gcc cgg gct cac tgg ggc tgc tgc ccc tgg ctg gtc ctc ctc       289
     Met Ala Arg Ala His Trp Gly Cys Cys Pro Trp Leu Val Leu Leu          
     1               5                   10                  15           

tgt gct tgt gcc tgg ggc cac aca aag cca gtg gac ctt gga ggg cag        337
Cys Ala Cys Ala Trp Gly His Thr Lys Pro Val Asp Leu Gly Gly Gln           
                20                  25                  30                

gat gtg aga aac tgt tcc acc aac ccc cct tac ctt cca gtt act gtg        385
Asp Val Arg Asn Cys Ser Thr Asn Pro Pro Tyr Leu Pro Val Thr Val           
            35                  40                  45                    

gtc aat acc aca atg tca ctc aca gcc ctc cgc cag cag atg cag acc        433
Val Asn Thr Thr Met Ser Leu Thr Ala Leu Arg Gln Gln Met Gln Thr           
        50                  55                  60                        

cag aat ctc tca gcc tac atc atc cca ggc aca gat gct cac atg aac        481
Gln Asn Leu Ser Ala Tyr Ile Ile Pro Gly Thr Asp Ala His Met Asn           
    65                  70                  75                            

gag tac atc ggc caa cat gac gag agg cgt gcg tgg att aca ggc ttt        529
Glu Tyr Ile Gly Gln His Asp Glu Arg Arg Ala Trp Ile Thr Gly Phe           
80                  85                  90                  95            

aca ggg tct gca gga act gca gtg gtg act atg aag aaa gca gct gtc        577
Thr Gly Ser Ala Gly Thr Ala Val Val Thr Met Lys Lys Ala Ala Val           
                100                 105                 110               

tgg acc gac agt cgc tac tgg act cag gct gag cgg cag atg gac tgc        625
Trp Thr Asp Ser Arg Tyr Trp Thr Gln Ala Glu Arg Gln Met Asp Cys           
            115                 120                 125                   

aac tgg gag ctc cat aag gaa gtt ggc acc act cct att gtc acc tgg        673
Asn Trp Glu Leu His Lys Glu Val Gly Thr Thr Pro Ile Val Thr Trp           
        130                 135                 140                       

ctc ctc acc gag att cct gct gga ggg cgt gtg ggt ttt gac ccc ttc        721
Leu Leu Thr Glu Ile Pro Ala Gly Gly Arg Val Gly Phe Asp Pro Phe           
    145                 150                 155                           

ctc ttg tcc att gac acc tgg gag agt tat gat ctg gcc ctc caa ggc        769
Leu Leu Ser Ile Asp Thr Trp Glu Ser Tyr Asp Leu Ala Leu Gln Gly           
160                 165                 170                 175           

tct aac aga cag ctg gtg tcc atc aca acc aat ctt gtg gac ctg gta        817
Ser Asn Arg Gln Leu Val Ser Ile Thr Thr Asn Leu Val Asp Leu Val           
                180                 185                 190               

tgg gga tca gag agg cca ccg gtt cca aat caa ccc att tat gcc ctg        865
Trp Gly Ser Glu Arg Pro Pro Val Pro Asn Gln Pro Ile Tyr Ala Leu           
            195                 200                 205                   

cag gag gca ttc aca ggg agc act tgg cag gag aaa gta tct ggc gtc        913
Gln Glu Ala Phe Thr Gly Ser Thr Trp Gln Glu Lys Val Ser Gly Val           
        210                 215                 220                       

cga agc cag atg cag aag cat caa aag gtc ccg act gcc gtc ctt ctg        961
Arg Ser Gln Met Gln Lys His Gln Lys Val Pro Thr Ala Val Leu Leu           
    225                 230                 235                           

tcg gcg ctt gag gag acg gcc tgg ctc ttc aac ctt cga gcc agt gac       1009
Ser Ala Leu Glu Glu Thr Ala Trp Leu Phe Asn Leu Arg Ala Ser Asp           
240                 245                 250                 255           

atc ccc tat aac ccc ttc ttc tat tcc tac acg ctg ctc aca gac tct       1057
Ile Pro Tyr Asn Pro Phe Phe Tyr Ser Tyr Thr Leu Leu Thr Asp Ser           
                260                 265                 270               

tct att agg ttg ttt gca aac aag agt cgc ttt agc tcc gaa acc ttg       1105
Ser Ile Arg Leu Phe Ala Asn Lys Ser Arg Phe Ser Ser Glu Thr Leu           
            275                 280                 285                   

agc tat ctg aac tcc agt tgc aca ggc ccc atg tgt gtg caa atc gag       1153
Ser Tyr Leu Asn Ser Ser Cys Thr Gly Pro Met Cys Val Gln Ile Glu           
        290                 295                 300                       

gat tac agc caa gtt cgt gac agc atc cag gcc tac tca ttg gga gat       1201
Asp Tyr Ser Gln Val Arg Asp Ser Ile Gln Ala Tyr Ser Leu Gly Asp           
    305                 310                 315                           

gtg agg atc tgg att ggg acc agc tat acc atg tat ggg atc tat gaa       1249
Val Arg Ile Trp Ile Gly Thr Ser Tyr Thr Met Tyr Gly Ile Tyr Glu           
320                 325                 330                 335           

atg ata ccc aag gag aaa ctc gtg aca gac acc tac tcc cca gtg atg       1297
Met Ile Pro Lys Glu Lys Leu Val Thr Asp Thr Tyr Ser Pro Val Met           
                340                 345                 350               

atg acc aag gca gtg aag aac agc aag gag cag gcc ctc ctc aag gcc       1345
Met Thr Lys Ala Val Lys Asn Ser Lys Glu Gln Ala Leu Leu Lys Ala           
            355                 360                 365                   

agc cac gtg cgg gac gct gtg gct gtg atc cgg tac ttg gtc tgg ctg       1393
Ser His Val Arg Asp Ala Val Ala Val Ile Arg Tyr Leu Val Trp Leu           
        370                 375                 380                       

gag aag aac gtg ccc aaa ggc aca gtg gat gag ttc tcg ggg gca gag       1441
Glu Lys Asn Val Pro Lys Gly Thr Val Asp Glu Phe Ser Gly Ala Glu           
    385                 390                 395                           

atc gtg gac aag ttc cga gga gaa gaa cag ttc tcc tcc gga ccc agt       1489
Ile Val Asp Lys Phe Arg Gly Glu Glu Gln Phe Ser Ser Gly Pro Ser           
400                 405                 410                 415           

ttt gaa acc atc tct gct agt ggt ctg aat gct gcc ctg gcc cac tac       1537
Phe Glu Thr Ile Ser Ala Ser Gly Leu Asn Ala Ala Leu Ala His Tyr           
                420                 425                 430               

agc ccg acc aag gag ctg aac cgc aag ctg tcc tca gat gag atg tac       1585
Ser Pro Thr Lys Glu Leu Asn Arg Lys Leu Ser Ser Asp Glu Met Tyr           
            435                 440                 445                   

ctg ctg gac tct ggg ggg cag tac tgg gac ggg acc aca gac atc acc       1633
Leu Leu Asp Ser Gly Gly Gln Tyr Trp Asp Gly Thr Thr Asp Ile Thr           
        450                 455                 460                       

aga aca gtc cac tgg ggc acc ccc tct gcc ttc cag aag gag gca tac       1681
Arg Thr Val His Trp Gly Thr Pro Ser Ala Phe Gln Lys Glu Ala Tyr           
    465                 470                 475                           

acc cgt gtg ctg ata gga aat att gac ctg tcc agg ctc atc ttt ccc       1729
Thr Arg Val Leu Ile Gly Asn Ile Asp Leu Ser Arg Leu Ile Phe Pro           
480                 485                 490                 495           

gct gct aca tca ggg cga atg gtg gag gcc ttt gcc cgc aga gcc ttg       1777
Ala Ala Thr Ser Gly Arg Met Val Glu Ala Phe Ala Arg Arg Ala Leu           
                500                 505                 510               

tgg gat gct ggt ctc aat tat ggt cat ggg aca ggc cac ggc att ggc       1825
Trp Asp Ala Gly Leu Asn Tyr Gly His Gly Thr Gly His Gly Ile Gly           
            515                 520                 525                   

aac ttc ctg tgt gtg cat gag tgg cca gtg gga ttc cag tcc aac aac       1873
Asn Phe Leu Cys Val His Glu Trp Pro Val Gly Phe Gln Ser Asn Asn           
        530                 535                 540                       

atc gct atg gcc aag ggc atg ttc act tcc att gaa cct ggt tac tat       1921
Ile Ala Met Ala Lys Gly Met Phe Thr Ser Ile Glu Pro Gly Tyr Tyr           
    545                 550                 555                           

aag gat gga gaa ttt ggg atc cgt ctc gaa gat gtg gct ctc gtg gta       1969
Lys Asp Gly Glu Phe Gly Ile Arg Leu Glu Asp Val Ala Leu Val Val           
560                 565                 570                 575           

gaa gca aag acc aag tac cca ggg agc tac ctg acc ttt gaa gtg gta       2017
Glu Ala Lys Thr Lys Tyr Pro Gly Ser Tyr Leu Thr Phe Glu Val Val           
                580                 585                 590               

tca ttt gtg ccc tat gac cgg aac ctc atc gat gtc agc ctg ctg tct       2065
Ser Phe Val Pro Tyr Asp Arg Asn Leu Ile Asp Val Ser Leu Leu Ser           
            595                 600                 605                   

ccc gag cat ctc cag tac ctg aat cgc tac tac cag acc atc cgg gag       2113
Pro Glu His Leu Gln Tyr Leu Asn Arg Tyr Tyr Gln Thr Ile Arg Glu           
        610                 615                 620                       

aag gtg ggt cca gag ctg cag agg cgc cag cta cta gag gag ttc gag       2161
Lys Val Gly Pro Glu Leu Gln Arg Arg Gln Leu Leu Glu Glu Phe Glu           
    625                 630                 635                           

tgg ctt caa cag cac aca gag ccc ctg gcc gcc agg gcc cca gac acc       2209
Trp Leu Gln Gln His Thr Glu Pro Leu Ala Ala Arg Ala Pro Asp Thr           
640                 645                 650                 655           

gcc tcc tgg gcc tct gtg tta gtg gtc tcc acc ctt gcc atc ctt ggc       2257
Ala Ser Trp Ala Ser Val Leu Val Val Ser Thr Leu Ala Ile Leu Gly           
                660                 665                 670               

tgg agt gtc tag aggctccaga ctctcctgtt aaccctccat ctagatgggg           2309
Trp Ser Val                                                               
                                                                          

ggctcccttg cttagctccc ctcaccctgc actgaacata ccccaagagc ccctgctggc     2369

ccattgccta gaaacctttg cattcatcct ccttctccaa gacctatgga gaaggtccca     2429

ggccccagga acacagggct tcttggcccc agatggcacc tccctgcacc ccggggttgt     2489

ataccacacc ctgggcccct aatcccaggc cccgagatag gaaagccagc tagtctcttc     2549

tcttctgtga tctcagtagg cctaacctat aacctagcac agactgctac agctgctccc     2609

ctcccgccaa acaaaacccc aagagagcaa tgcccctacc acccaagggt gccatggtcc     2669

cgggagagcc caaacctatc accacctgtt gggcatagcc agagctgttc ccacccagcc     2729

agggcatgaa acatcaaccc cccacatgtg aacccatcat tcctaaaccc tgggtaggct     2789

ccatgccaag taacagcaga gggagttaag ccataggaat ttggctgtgg agtaagaggg     2849

aatgcggtga ggcactctgg aatatgaccc taccagaggt tggagaacaa acttgggcag     2909

ccggaacccg tcactattct agacttccct ggcattcgag gagccctttg aactttccaa     2969

agtgcagcca cagctacaat gctgttaaat cctcccacat tcttggatgc cccttcacct     3029

tgtgtggaca gtgtctggtt tctccatttt acagacagga aaactgagct tcagacaggg     3089

ggtgggcttt gcctaaggac acacaaattt ggttgggagt tgatggggcc agatgagcca     3149

gcattccagc tctttcaccc ttcagcaaca tgcagagtcc ctgagcccac ctcccagccc     3209

tctcctcatt ctctgaaccc actgtggtga gaagaatttg ctccggccaa attggccgtt     3269

agccacctgg gtccacatcc tgctaagacg tttaaaacag cctaacaaag acacttgcct     3329

ctgg                                                                  3333


<210>  556
<211>  674
<212>  PRT
<213>  Homo sapiens

<400>  556

Met Ala Arg Ala His Trp Gly Cys Cys Pro Trp Leu Val Leu Leu Cys 
1               5                   10                  15      


Ala Cys Ala Trp Gly His Thr Lys Pro Val Asp Leu Gly Gly Gln Asp 
            20                  25                  30          


Val Arg Asn Cys Ser Thr Asn Pro Pro Tyr Leu Pro Val Thr Val Val 
        35                  40                  45              


Asn Thr Thr Met Ser Leu Thr Ala Leu Arg Gln Gln Met Gln Thr Gln 
    50                  55                  60                  


Asn Leu Ser Ala Tyr Ile Ile Pro Gly Thr Asp Ala His Met Asn Glu 
65                  70                  75                  80  


Tyr Ile Gly Gln His Asp Glu Arg Arg Ala Trp Ile Thr Gly Phe Thr 
                85                  90                  95      


Gly Ser Ala Gly Thr Ala Val Val Thr Met Lys Lys Ala Ala Val Trp 
            100                 105                 110         


Thr Asp Ser Arg Tyr Trp Thr Gln Ala Glu Arg Gln Met Asp Cys Asn 
        115                 120                 125             


Trp Glu Leu His Lys Glu Val Gly Thr Thr Pro Ile Val Thr Trp Leu 
    130                 135                 140                 


Leu Thr Glu Ile Pro Ala Gly Gly Arg Val Gly Phe Asp Pro Phe Leu 
145                 150                 155                 160 


Leu Ser Ile Asp Thr Trp Glu Ser Tyr Asp Leu Ala Leu Gln Gly Ser 
                165                 170                 175     


Asn Arg Gln Leu Val Ser Ile Thr Thr Asn Leu Val Asp Leu Val Trp 
            180                 185                 190         


Gly Ser Glu Arg Pro Pro Val Pro Asn Gln Pro Ile Tyr Ala Leu Gln 
        195                 200                 205             


Glu Ala Phe Thr Gly Ser Thr Trp Gln Glu Lys Val Ser Gly Val Arg 
    210                 215                 220                 


Ser Gln Met Gln Lys His Gln Lys Val Pro Thr Ala Val Leu Leu Ser 
225                 230                 235                 240 


Ala Leu Glu Glu Thr Ala Trp Leu Phe Asn Leu Arg Ala Ser Asp Ile 
                245                 250                 255     


Pro Tyr Asn Pro Phe Phe Tyr Ser Tyr Thr Leu Leu Thr Asp Ser Ser 
            260                 265                 270         


Ile Arg Leu Phe Ala Asn Lys Ser Arg Phe Ser Ser Glu Thr Leu Ser 
        275                 280                 285             


Tyr Leu Asn Ser Ser Cys Thr Gly Pro Met Cys Val Gln Ile Glu Asp 
    290                 295                 300                 


Tyr Ser Gln Val Arg Asp Ser Ile Gln Ala Tyr Ser Leu Gly Asp Val 
305                 310                 315                 320 


Arg Ile Trp Ile Gly Thr Ser Tyr Thr Met Tyr Gly Ile Tyr Glu Met 
                325                 330                 335     


Ile Pro Lys Glu Lys Leu Val Thr Asp Thr Tyr Ser Pro Val Met Met 
            340                 345                 350         


Thr Lys Ala Val Lys Asn Ser Lys Glu Gln Ala Leu Leu Lys Ala Ser 
        355                 360                 365             


His Val Arg Asp Ala Val Ala Val Ile Arg Tyr Leu Val Trp Leu Glu 
    370                 375                 380                 


Lys Asn Val Pro Lys Gly Thr Val Asp Glu Phe Ser Gly Ala Glu Ile 
385                 390                 395                 400 


Val Asp Lys Phe Arg Gly Glu Glu Gln Phe Ser Ser Gly Pro Ser Phe 
                405                 410                 415     


Glu Thr Ile Ser Ala Ser Gly Leu Asn Ala Ala Leu Ala His Tyr Ser 
            420                 425                 430         


Pro Thr Lys Glu Leu Asn Arg Lys Leu Ser Ser Asp Glu Met Tyr Leu 
        435                 440                 445             


Leu Asp Ser Gly Gly Gln Tyr Trp Asp Gly Thr Thr Asp Ile Thr Arg 
    450                 455                 460                 


Thr Val His Trp Gly Thr Pro Ser Ala Phe Gln Lys Glu Ala Tyr Thr 
465                 470                 475                 480 


Arg Val Leu Ile Gly Asn Ile Asp Leu Ser Arg Leu Ile Phe Pro Ala 
                485                 490                 495     


Ala Thr Ser Gly Arg Met Val Glu Ala Phe Ala Arg Arg Ala Leu Trp 
            500                 505                 510         


Asp Ala Gly Leu Asn Tyr Gly His Gly Thr Gly His Gly Ile Gly Asn 
        515                 520                 525             


Phe Leu Cys Val His Glu Trp Pro Val Gly Phe Gln Ser Asn Asn Ile 
    530                 535                 540                 


Ala Met Ala Lys Gly Met Phe Thr Ser Ile Glu Pro Gly Tyr Tyr Lys 
545                 550                 555                 560 


Asp Gly Glu Phe Gly Ile Arg Leu Glu Asp Val Ala Leu Val Val Glu 
                565                 570                 575     


Ala Lys Thr Lys Tyr Pro Gly Ser Tyr Leu Thr Phe Glu Val Val Ser 
            580                 585                 590         


Phe Val Pro Tyr Asp Arg Asn Leu Ile Asp Val Ser Leu Leu Ser Pro 
        595                 600                 605             


Glu His Leu Gln Tyr Leu Asn Arg Tyr Tyr Gln Thr Ile Arg Glu Lys 
    610                 615                 620                 


Val Gly Pro Glu Leu Gln Arg Arg Gln Leu Leu Glu Glu Phe Glu Trp 
625                 630                 635                 640 


Leu Gln Gln His Thr Glu Pro Leu Ala Ala Arg Ala Pro Asp Thr Ala 
                645                 650                 655     


Ser Trp Ala Ser Val Leu Val Val Ser Thr Leu Ala Ile Leu Gly Trp 
            660                 665                 670         


Ser Val 
        


<210>  557
<211>  2938
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (249)..(1487)

<400>  557
gcgcgggccg ctgtgaggcg cggcggcgag cgacgggcgc ggggccgcgg agcagcgagc       60

gagcgagcga gcgcgaggcc ggagccccgg ccaggcccgg ccgacccgcc gagcccgcga      120

tgcgccccgg ggccgccccc cggcgcagct gacgccccgc ggccccgcga agaccccggc      180

cggccggtcc cggaggaagc ggccgccgcc gccgccgccc agcccagcgc ccgcgccgcc      240

cgggcacc atg gcg ggg aag gcg gcc gcc ccg ggc acc gcg gtg ctg ctg       290
         Met Ala Gly Lys Ala Ala Ala Pro Gly Thr Ala Val Leu Leu          
         1               5                   10                           

gtc acg gcc aac gtg ggc tcg ctc ttc gac gac cca gaa aac ctg cag        338
Val Thr Ala Asn Val Gly Ser Leu Phe Asp Asp Pro Glu Asn Leu Gln           
15                  20                  25                  30            

aag aac tgg ctt cgg gaa ttt tac cag gtc gtg cac aca cac aag ccg        386
Lys Asn Trp Leu Arg Glu Phe Tyr Gln Val Val His Thr His Lys Pro           
                35                  40                  45                

cac ttc atg gcc ttg cac tgt cag gag ttt gga ggg aag aac tac gag        434
His Phe Met Ala Leu His Cys Gln Glu Phe Gly Gly Lys Asn Tyr Glu           
            50                  55                  60                    

gcc tcc atg tcc cac gtg gac aag ttc gtc aaa gaa cta ttg tcg agt        482
Ala Ser Met Ser His Val Asp Lys Phe Val Lys Glu Leu Leu Ser Ser           
        65                  70                  75                        

gat gcg atg aaa gaa tat aac agg gct cga gtc tac ctg gat gaa aac        530
Asp Ala Met Lys Glu Tyr Asn Arg Ala Arg Val Tyr Leu Asp Glu Asn           
    80                  85                  90                            

tac aaa tcc cag gag cac ttc acg gca cta gga agc ttt tat ttt ctt        578
Tyr Lys Ser Gln Glu His Phe Thr Ala Leu Gly Ser Phe Tyr Phe Leu           
95                  100                 105                 110           

cat gag tcc tta aaa aac atc tac cag ttt gac ttt aaa gct aag aag        626
His Glu Ser Leu Lys Asn Ile Tyr Gln Phe Asp Phe Lys Ala Lys Lys           
                115                 120                 125               

tat aga aag gtc gct ggc aaa gag atc tac tcg gat acc tta gag agc        674
Tyr Arg Lys Val Ala Gly Lys Glu Ile Tyr Ser Asp Thr Leu Glu Ser           
            130                 135                 140                   

acg ccc atg ctg gag aag gag aag ttt ccg cag gac tac ttc ccc gag        722
Thr Pro Met Leu Glu Lys Glu Lys Phe Pro Gln Asp Tyr Phe Pro Glu           
        145                 150                 155                       

tgc aaa tgg tca aga aaa ggc ttc atc cgg acg agg tgg tgc att gca        770
Cys Lys Trp Ser Arg Lys Gly Phe Ile Arg Thr Arg Trp Cys Ile Ala           
    160                 165                 170                           

gac tgt gcc ttt gac ttg gtg aat atc cat ctt ttc cat gat gct tcc        818
Asp Cys Ala Phe Asp Leu Val Asn Ile His Leu Phe His Asp Ala Ser           
175                 180                 185                 190           

aat ctg gtc gcc tgg gaa aca agc cct tcc gtg tac tcg gga atc cgg        866
Asn Leu Val Ala Trp Glu Thr Ser Pro Ser Val Tyr Ser Gly Ile Arg           
                195                 200                 205               

cac aag gca ctg ggc tac gtg ctg gac aga atc att gat cag cga ttc        914
His Lys Ala Leu Gly Tyr Val Leu Asp Arg Ile Ile Asp Gln Arg Phe           
            210                 215                 220                   

gag aag gtt tcc tac ttt gta ttt ggt gat ttc aac ttc cgg ctg gat        962
Glu Lys Val Ser Tyr Phe Val Phe Gly Asp Phe Asn Phe Arg Leu Asp           
        225                 230                 235                       

tcc aag tcc gtc gtg gag acg ctc tgc aca aaa gcc acc atg cag acg       1010
Ser Lys Ser Val Val Glu Thr Leu Cys Thr Lys Ala Thr Met Gln Thr           
    240                 245                 250                           

gtc cgg gcc gcc gac acc aat gaa gtg gtg aag ctc ata ttt cgt gag       1058
Val Arg Ala Ala Asp Thr Asn Glu Val Val Lys Leu Ile Phe Arg Glu           
255                 260                 265                 270           

tcg gac aac gac cgg aag gtt atg ctc cag tta gaa aag aaa ctc ttc       1106
Ser Asp Asn Asp Arg Lys Val Met Leu Gln Leu Glu Lys Lys Leu Phe           
                275                 280                 285               

gac tac ttc aac cag gag gtt ttc cga gac aac aac ggc acc gcg ctc       1154
Asp Tyr Phe Asn Gln Glu Val Phe Arg Asp Asn Asn Gly Thr Ala Leu           
            290                 295                 300                   

ttg gag ttt gac aag gag ttg tct gtc ttt aag gac aga ctg tat gaa       1202
Leu Glu Phe Asp Lys Glu Leu Ser Val Phe Lys Asp Arg Leu Tyr Glu           
        305                 310                 315                       

ctg gac atc tcg ttc cct ccc agc tac ccg tac agt gag gac gcc cgc       1250
Leu Asp Ile Ser Phe Pro Pro Ser Tyr Pro Tyr Ser Glu Asp Ala Arg           
    320                 325                 330                           

cag ggt gag cag tac atg aac acc cgg tgc cca gcc tgg tgt gac cgc       1298
Gln Gly Glu Gln Tyr Met Asn Thr Arg Cys Pro Ala Trp Cys Asp Arg           
335                 340                 345                 350           

atc ctc atg tcc ccg tct gcc aag gag ctg gtg ctg cgg tcg gag agc       1346
Ile Leu Met Ser Pro Ser Ala Lys Glu Leu Val Leu Arg Ser Glu Ser           
                355                 360                 365               

gag gag aag gtt gtc acc tat gac cac att ggg ccc aac gtc tgc atg       1394
Glu Glu Lys Val Val Thr Tyr Asp His Ile Gly Pro Asn Val Cys Met           
            370                 375                 380                   

gga gac cac aag ccc gtg ttc ctg gcc ttc cga atc atg ccc ggg gca       1442
Gly Asp His Lys Pro Val Phe Leu Ala Phe Arg Ile Met Pro Gly Ala           
        385                 390                 395                       

ggt aaa cct cat gcc cat gtg cac aag tgt tgt gtc gtg cag tga           1487
Gly Lys Pro His Ala His Val His Lys Cys Cys Val Val Gln                   
    400                 405                 410                           

cgtggtggga agagatgcca gcgccacgag aggacacttc gtgagcctcc ctgtagccgt     1547

ggaccgaata cgcactcttg aaagctgcat cgagaacccg cccaagcgcc acctgctaga     1607

cggccagccc cacacttcgc ttcagcctcc ggaccattcc ggagcagcct cacatacctc     1667

actgtctcgt ctgtctatgt gacattaagt agaaatattg gttttttttt ttttttttta     1727

aataagtcac agtcctgttg tcaaaactct aatagacagc aaagagggtc tgtaccgtag     1787

acttcacagt tttcagtttt taatgattgc cagtggaggg gcttcttcag cacagagacc     1847

ccccactgtg tccagggacc ccctctgcca ggtggaggtg tgtccagggg ctggggaagc     1907

cgagacgggc actccctctg ccggccggca gcgtggccct gagcatggca agggggtctg     1967

tctctgccga tgctccttcc gcggcactga ctctgcgccg tgtcacatgg tttttgaatc     2027

acactgcagc tgctttccat ttttatatat atataaatat atataaatat atacttttta     2087

aaaataattt ataaatctta ccaaaactta tgctaaatat actttccagt atgaacgcac     2147

aggagagtcc catcagcagg cggcattgga gtctaggagc tcagctgtgt gtccatcaac     2207

acacaaattc gtaaaaaaca cacatggcct cgccatcgtg ggtaaaatcg gccccacagc     2267

acgtctgcac cagcgggccg ttactcccat gccgttcttc tgtgtaatat taagaactga     2327

atgtgaagtt tatagctagc ctgggtgtac cttttaagaa ttttgtaaac cgtttgtctg     2387

tcttttgtta ctgttttatg gtgccaagta tcctacgtta caacaataat atcatgggag     2447

aaatagaaat agcctagttt gcttccaata gaaactgctt ttaacatggg ctgtatataa     2507

aaatattaaa gagaaacaaa actgtacatt tcctcattgc tccgctacag acaacccatg     2567

tcataacctt gttgcaaata tttttctcct atagcagtaa gtacagcatt agaaggtgat     2627

tagagagtct gttgatgaaa cacaaatgta tgttttattg attttacttt agaacactac     2687

agagttcctg gaccgggtga aggcattagc tgggtgtttg tgtgggataa atactaccac     2747

tgcaagtgac tgctgtccgc tgcggaatct gttcttggtg gaagcacagg tccgtgtcgc     2807

tgctgtggtt gccgctgtcc gcggttcaac acggagtccg ccccgcgggt ttcagctgtt     2867

ggtcgttctg aggggccttt ggaagtgacc ggtctggttc ctaagcaata aaattgaccg     2927

tggtgaaaat a                                                          2938


<210>  558
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  558

Met Ala Gly Lys Ala Ala Ala Pro Gly Thr Ala Val Leu Leu Val Thr 
1               5                   10                  15      


Ala Asn Val Gly Ser Leu Phe Asp Asp Pro Glu Asn Leu Gln Lys Asn 
            20                  25                  30          


Trp Leu Arg Glu Phe Tyr Gln Val Val His Thr His Lys Pro His Phe 
        35                  40                  45              


Met Ala Leu His Cys Gln Glu Phe Gly Gly Lys Asn Tyr Glu Ala Ser 
    50                  55                  60                  


Met Ser His Val Asp Lys Phe Val Lys Glu Leu Leu Ser Ser Asp Ala 
65                  70                  75                  80  


Met Lys Glu Tyr Asn Arg Ala Arg Val Tyr Leu Asp Glu Asn Tyr Lys 
                85                  90                  95      


Ser Gln Glu His Phe Thr Ala Leu Gly Ser Phe Tyr Phe Leu His Glu 
            100                 105                 110         


Ser Leu Lys Asn Ile Tyr Gln Phe Asp Phe Lys Ala Lys Lys Tyr Arg 
        115                 120                 125             


Lys Val Ala Gly Lys Glu Ile Tyr Ser Asp Thr Leu Glu Ser Thr Pro 
    130                 135                 140                 


Met Leu Glu Lys Glu Lys Phe Pro Gln Asp Tyr Phe Pro Glu Cys Lys 
145                 150                 155                 160 


Trp Ser Arg Lys Gly Phe Ile Arg Thr Arg Trp Cys Ile Ala Asp Cys 
                165                 170                 175     


Ala Phe Asp Leu Val Asn Ile His Leu Phe His Asp Ala Ser Asn Leu 
            180                 185                 190         


Val Ala Trp Glu Thr Ser Pro Ser Val Tyr Ser Gly Ile Arg His Lys 
        195                 200                 205             


Ala Leu Gly Tyr Val Leu Asp Arg Ile Ile Asp Gln Arg Phe Glu Lys 
    210                 215                 220                 


Val Ser Tyr Phe Val Phe Gly Asp Phe Asn Phe Arg Leu Asp Ser Lys 
225                 230                 235                 240 


Ser Val Val Glu Thr Leu Cys Thr Lys Ala Thr Met Gln Thr Val Arg 
                245                 250                 255     


Ala Ala Asp Thr Asn Glu Val Val Lys Leu Ile Phe Arg Glu Ser Asp 
            260                 265                 270         


Asn Asp Arg Lys Val Met Leu Gln Leu Glu Lys Lys Leu Phe Asp Tyr 
        275                 280                 285             


Phe Asn Gln Glu Val Phe Arg Asp Asn Asn Gly Thr Ala Leu Leu Glu 
    290                 295                 300                 


Phe Asp Lys Glu Leu Ser Val Phe Lys Asp Arg Leu Tyr Glu Leu Asp 
305                 310                 315                 320 


Ile Ser Phe Pro Pro Ser Tyr Pro Tyr Ser Glu Asp Ala Arg Gln Gly 
                325                 330                 335     


Glu Gln Tyr Met Asn Thr Arg Cys Pro Ala Trp Cys Asp Arg Ile Leu 
            340                 345                 350         


Met Ser Pro Ser Ala Lys Glu Leu Val Leu Arg Ser Glu Ser Glu Glu 
        355                 360                 365             


Lys Val Val Thr Tyr Asp His Ile Gly Pro Asn Val Cys Met Gly Asp 
    370                 375                 380                 


His Lys Pro Val Phe Leu Ala Phe Arg Ile Met Pro Gly Ala Gly Lys 
385                 390                 395                 400 


Pro His Ala His Val His Lys Cys Cys Val Val Gln 
                405                 410         


<210>  559
<211>  2778
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (694)..(2226)

<400>  559
agctccttcc cgcggctctg cgatgcggcc cgcagggtga cccgggcggg agtccgggga       60

cccgcgatca gccccggagg acggggtggg gtcgccccaa acaggagcgc cgggaccgct      120

gggaccccgc actcggcgtc cgccgccgcc gggtagccgg gcagtggagg tcccggatga      180

ggcgacaatt tttccggccc cccctcccag tcccgcccca cttccggggc cgccactttc      240

actttctctt ccgccgaagc cgctcccctt gcgaagaact ggggcctccc gggaggagag      300

agggctttgc cttgaaaccc gggacgccag gggcgctccc gcaagtgggg gtcctccggg      360

acttggaacg ccccggctgg gtggtgtccg ggcgtccttt ccccgcttct tcccacctcg      420

gctggtcccg tttcctcctg cgcccagtgc ggacctgtct cggcgcccgc tgccctctca      480

ccgccccacg caggatcccg gcctggtcac cgggcagtgt gatgcttccc gactgccgcg      540

gggacagcga ggcacacaca gggcttgggc cgcgccggag gccacacggc ctggctgagt      600

tgctcctggt ctcccgcctc tcccaggcga cccggaggta gcatttccca ggaggcacgg      660

tcccccccag ggggatgggc acagccacgc cag atg gac gag aag acc aag aaa       714
                                     Met Asp Glu Lys Thr Lys Lys          
                                     1               5                    

gca gag gaa atg gcc ctg agc ctc acc cga gca gtg gcg ggc ggg gat        762
Ala Glu Glu Met Ala Leu Ser Leu Thr Arg Ala Val Ala Gly Gly Asp           
        10                  15                  20                        

gaa cag gtg gca atg aag tgt gcc atc tgg ctg gca gag caa cgg gtg        810
Glu Gln Val Ala Met Lys Cys Ala Ile Trp Leu Ala Glu Gln Arg Val           
    25                  30                  35                            

ccc ctg agt gtg caa ctg aag cct gag gtc tcc cca acg cag gac atc        858
Pro Leu Ser Val Gln Leu Lys Pro Glu Val Ser Pro Thr Gln Asp Ile           
40                  45                  50                  55            

agg ctg tgg gtg agc gtg gag gat gct cag atg cac acc gtc acc atc        906
Arg Leu Trp Val Ser Val Glu Asp Ala Gln Met His Thr Val Thr Ile           
                60                  65                  70                

tgg ctc aca gtg cgc cct gat atg aca gtg gcg tct ctc aag gac atg        954
Trp Leu Thr Val Arg Pro Asp Met Thr Val Ala Ser Leu Lys Asp Met           
            75                  80                  85                    

gtt ttt ctg gac tat ggc ttc cca cca gtc ttg cag cag tgg gtg att       1002
Val Phe Leu Asp Tyr Gly Phe Pro Pro Val Leu Gln Gln Trp Val Ile           
        90                  95                  100                       

ggg cag cgg ctg gca cga gac cag gag acc ctg cac tcc cat ggg gtg       1050
Gly Gln Arg Leu Ala Arg Asp Gln Glu Thr Leu His Ser His Gly Val           
    105                 110                 115                           

cgg cag aat ggg gac agt gcc tac ctc tat ctg ctg tca gcc cgc aac       1098
Arg Gln Asn Gly Asp Ser Ala Tyr Leu Tyr Leu Leu Ser Ala Arg Asn           
120                 125                 130                 135           

acc tcc ctc aac cct cag gag ctg cag cgg gag cgg cag ctg cgg atg       1146
Thr Ser Leu Asn Pro Gln Glu Leu Gln Arg Glu Arg Gln Leu Arg Met           
                140                 145                 150               

ctg gaa gat ctg ggc ttc aag gac ctc acg ctg cag ccg cgg ggc cct       1194
Leu Glu Asp Leu Gly Phe Lys Asp Leu Thr Leu Gln Pro Arg Gly Pro           
            155                 160                 165                   

ctg gag cca ggc ccc cca aag ccc ggg gtc ccc cag gaa ccc gga cgg       1242
Leu Glu Pro Gly Pro Pro Lys Pro Gly Val Pro Gln Glu Pro Gly Arg           
        170                 175                 180                       

ggg cag cca gat gca gtg cct gag ccc cca ccg gtg ggc tgg cag tgc       1290
Gly Gln Pro Asp Ala Val Pro Glu Pro Pro Pro Val Gly Trp Gln Cys           
    185                 190                 195                           

ccc ggg tgc acc ttc atc aac aag ccc acg cgg cct ggc tgt gag atg       1338
Pro Gly Cys Thr Phe Ile Asn Lys Pro Thr Arg Pro Gly Cys Glu Met           
200                 205                 210                 215           

tgc tgc cgg gcg cgc ccc gag gcc tac cag gtc ccc gcc tca tac cag       1386
Cys Cys Arg Ala Arg Pro Glu Ala Tyr Gln Val Pro Ala Ser Tyr Gln           
                220                 225                 230               

ccc gac gag gag gag cga gcg cgc ctg gcg ggc gag gag gag gcg ctg       1434
Pro Asp Glu Glu Glu Arg Ala Arg Leu Ala Gly Glu Glu Glu Ala Leu           
            235                 240                 245                   

cgt cag tac cag cag cgg aag cag cag cag cag gag ggg aac tac ctg       1482
Arg Gln Tyr Gln Gln Arg Lys Gln Gln Gln Gln Glu Gly Asn Tyr Leu           
        250                 255                 260                       

cag cac gtc cag ctg gac cag agg agc ctg gtg ctg aac acg gag ccc       1530
Gln His Val Gln Leu Asp Gln Arg Ser Leu Val Leu Asn Thr Glu Pro           
    265                 270                 275                           

gcc gag tgc ccc gtg tgc tac tcg gtg ctg gcg ccc ggc gag gcc gtg       1578
Ala Glu Cys Pro Val Cys Tyr Ser Val Leu Ala Pro Gly Glu Ala Val           
280                 285                 290                 295           

gtg ctg cgt gag tgt ctg cac acc ttc tgc agg gag tgc ctg cag ggc       1626
Val Leu Arg Glu Cys Leu His Thr Phe Cys Arg Glu Cys Leu Gln Gly           
                300                 305                 310               

acc atc cgc aac agc cag gag gcg gag gtc tcc tgc ccc ttc att gac       1674
Thr Ile Arg Asn Ser Gln Glu Ala Glu Val Ser Cys Pro Phe Ile Asp           
            315                 320                 325                   

aac acc tac tcg tgc tcg ggc aag ctg ctg gag agg gag atc aag gcg       1722
Asn Thr Tyr Ser Cys Ser Gly Lys Leu Leu Glu Arg Glu Ile Lys Ala           
        330                 335                 340                       

ctc ctg acc cct gag gat tac cag cga ttt cta gac ctg ggc atc tcc       1770
Leu Leu Thr Pro Glu Asp Tyr Gln Arg Phe Leu Asp Leu Gly Ile Ser           
    345                 350                 355                           

att gct gaa aac cgc agt gcc ttc agc tac cat tgc aag acc cca gat       1818
Ile Ala Glu Asn Arg Ser Ala Phe Ser Tyr His Cys Lys Thr Pro Asp           
360                 365                 370                 375           

tgc aag gga tgg tgc ttc ttt gag gat gat gtc aat gag ttc acc tgc       1866
Cys Lys Gly Trp Cys Phe Phe Glu Asp Asp Val Asn Glu Phe Thr Cys           
                380                 385                 390               

cct gtg tgt ttc cac gtc aac tgc ctg ctc tgc aag gcc atc cat gag       1914
Pro Val Cys Phe His Val Asn Cys Leu Leu Cys Lys Ala Ile His Glu           
            395                 400                 405                   

cag atg aac tgc aag gag tat cag gag gac ctg gcc ctg cgg gct cag       1962
Gln Met Asn Cys Lys Glu Tyr Gln Glu Asp Leu Ala Leu Arg Ala Gln           
        410                 415                 420                       

aac gat gtg gct gcc cgg cag acg aca gag atg ctg aag gtg atg ctg       2010
Asn Asp Val Ala Ala Arg Gln Thr Thr Glu Met Leu Lys Val Met Leu           
    425                 430                 435                           

cag cag ggc gag gcc atg cgc tgc ccc cag tgc cag atc gtg gta cag       2058
Gln Gln Gly Glu Ala Met Arg Cys Pro Gln Cys Gln Ile Val Val Gln           
440                 445                 450                 455           

aag aag gac ggc tgc gac tgg atc cgc tgc acc gtc tgc cac acc gag       2106
Lys Lys Asp Gly Cys Asp Trp Ile Arg Cys Thr Val Cys His Thr Glu           
                460                 465                 470               

atc tgc tgg gtc acc aag ggc cca cgc tgg ggc cct ggg ggc cca gga       2154
Ile Cys Trp Val Thr Lys Gly Pro Arg Trp Gly Pro Gly Gly Pro Gly           
            475                 480                 485                   

gac acc agc ggg ggc tgc cgc tgc agg gta aat ggg att cct tgc cac       2202
Asp Thr Ser Gly Gly Cys Arg Cys Arg Val Asn Gly Ile Pro Cys His           
        490                 495                 500                       

cca agc tgt cag aac tgc cac tga gctaaagatg gtggggccac atgctgaccc      2256
Pro Ser Cys Gln Asn Cys His                                               
    505                 510                                               

agccccacat ccacattctg ttagaatgta gctcagggag cttcgtggac ggccttgctt     2316

gctgtagcgt tgtaggggcc ctgcctgcac tgcggttgtc cacggtcaca tctgccccag     2376

tgcctttgtc cttcccttgg ggcttgccgg ccagacttct ctcccctgcg gctcccacct     2436

ctgcctgacc ccagccttaa acatagcccc tggccagagg ccttgctggg tggagcctct     2496

gtgtgactcc atactcctcc caccacaaca ctcatctgtc aaacaccaag cactctcagc     2556

ctccccgcct tcagctgtca gctttctggg gctaacttct ctgcctttgt ggttggaggc     2616

ctgaggcctc ttggaactct tgctaacctg ttcagagcca ggaaggagac tgcacagttt     2676

tgaaagcaca gcccgtcagg tccggctctg cgtctccctc tctgcagcct gtgtaagcta     2736

ttataattaa aatggttttc cgggaaaaaa aaaaaaaaaa aa                        2778


<210>  560
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  560

Met Asp Glu Lys Thr Lys Lys Ala Glu Glu Met Ala Leu Ser Leu Thr 
1               5                   10                  15      


Arg Ala Val Ala Gly Gly Asp Glu Gln Val Ala Met Lys Cys Ala Ile 
            20                  25                  30          


Trp Leu Ala Glu Gln Arg Val Pro Leu Ser Val Gln Leu Lys Pro Glu 
        35                  40                  45              


Val Ser Pro Thr Gln Asp Ile Arg Leu Trp Val Ser Val Glu Asp Ala 
    50                  55                  60                  


Gln Met His Thr Val Thr Ile Trp Leu Thr Val Arg Pro Asp Met Thr 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asp Met Val Phe Leu Asp Tyr Gly Phe Pro Pro 
                85                  90                  95      


Val Leu Gln Gln Trp Val Ile Gly Gln Arg Leu Ala Arg Asp Gln Glu 
            100                 105                 110         


Thr Leu His Ser His Gly Val Arg Gln Asn Gly Asp Ser Ala Tyr Leu 
        115                 120                 125             


Tyr Leu Leu Ser Ala Arg Asn Thr Ser Leu Asn Pro Gln Glu Leu Gln 
    130                 135                 140                 


Arg Glu Arg Gln Leu Arg Met Leu Glu Asp Leu Gly Phe Lys Asp Leu 
145                 150                 155                 160 


Thr Leu Gln Pro Arg Gly Pro Leu Glu Pro Gly Pro Pro Lys Pro Gly 
                165                 170                 175     


Val Pro Gln Glu Pro Gly Arg Gly Gln Pro Asp Ala Val Pro Glu Pro 
            180                 185                 190         


Pro Pro Val Gly Trp Gln Cys Pro Gly Cys Thr Phe Ile Asn Lys Pro 
        195                 200                 205             


Thr Arg Pro Gly Cys Glu Met Cys Cys Arg Ala Arg Pro Glu Ala Tyr 
    210                 215                 220                 


Gln Val Pro Ala Ser Tyr Gln Pro Asp Glu Glu Glu Arg Ala Arg Leu 
225                 230                 235                 240 


Ala Gly Glu Glu Glu Ala Leu Arg Gln Tyr Gln Gln Arg Lys Gln Gln 
                245                 250                 255     


Gln Gln Glu Gly Asn Tyr Leu Gln His Val Gln Leu Asp Gln Arg Ser 
            260                 265                 270         


Leu Val Leu Asn Thr Glu Pro Ala Glu Cys Pro Val Cys Tyr Ser Val 
        275                 280                 285             


Leu Ala Pro Gly Glu Ala Val Val Leu Arg Glu Cys Leu His Thr Phe 
    290                 295                 300                 


Cys Arg Glu Cys Leu Gln Gly Thr Ile Arg Asn Ser Gln Glu Ala Glu 
305                 310                 315                 320 


Val Ser Cys Pro Phe Ile Asp Asn Thr Tyr Ser Cys Ser Gly Lys Leu 
                325                 330                 335     


Leu Glu Arg Glu Ile Lys Ala Leu Leu Thr Pro Glu Asp Tyr Gln Arg 
            340                 345                 350         


Phe Leu Asp Leu Gly Ile Ser Ile Ala Glu Asn Arg Ser Ala Phe Ser 
        355                 360                 365             


Tyr His Cys Lys Thr Pro Asp Cys Lys Gly Trp Cys Phe Phe Glu Asp 
    370                 375                 380                 


Asp Val Asn Glu Phe Thr Cys Pro Val Cys Phe His Val Asn Cys Leu 
385                 390                 395                 400 


Leu Cys Lys Ala Ile His Glu Gln Met Asn Cys Lys Glu Tyr Gln Glu 
                405                 410                 415     


Asp Leu Ala Leu Arg Ala Gln Asn Asp Val Ala Ala Arg Gln Thr Thr 
            420                 425                 430         


Glu Met Leu Lys Val Met Leu Gln Gln Gly Glu Ala Met Arg Cys Pro 
        435                 440                 445             


Gln Cys Gln Ile Val Val Gln Lys Lys Asp Gly Cys Asp Trp Ile Arg 
    450                 455                 460                 


Cys Thr Val Cys His Thr Glu Ile Cys Trp Val Thr Lys Gly Pro Arg 
465                 470                 475                 480 


Trp Gly Pro Gly Gly Pro Gly Asp Thr Ser Gly Gly Cys Arg Cys Arg 
                485                 490                 495     


Val Asn Gly Ile Pro Cys His Pro Ser Cys Gln Asn Cys His 
            500                 505                 510 


<210>  561
<211>  9410
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (34)..(8433)

<400>  561
cgccctcgag tggaggacga gaaggaaagc acc atg acg tcc atc cat ttc gtg        54
                                     Met Thr Ser Ile His Phe Val          
                                     1               5                    

gtt cac ccg ctg ccg ggc acc gag gac cag ctc aat gac agg tta cga        102
Val His Pro Leu Pro Gly Thr Glu Asp Gln Leu Asn Asp Arg Leu Arg           
        10                  15                  20                        

gaa gtt tct gag aag ctg aac aaa tat aat tta aac agc cac ccc cct        150
Glu Val Ser Glu Lys Leu Asn Lys Tyr Asn Leu Asn Ser His Pro Pro           
    25                  30                  35                            

ttg aat gta ttg gaa cag gct act att aaa cag tgt gtg gtg gga cca        198
Leu Asn Val Leu Glu Gln Ala Thr Ile Lys Gln Cys Val Val Gly Pro           
40                  45                  50                  55            

aat cat gct gcc ttt ctt ctt gag gat ggt aga gtt tgc agg att ggt        246
Asn His Ala Ala Phe Leu Leu Glu Asp Gly Arg Val Cys Arg Ile Gly           
                60                  65                  70                

ttt tca gta cag cca gac aga ttg gaa ttg ggt aaa cct gat aat aat        294
Phe Ser Val Gln Pro Asp Arg Leu Glu Leu Gly Lys Pro Asp Asn Asn           
            75                  80                  85                    

gat ggg tca aag ttg aac agc aac tcg ggg gca ggg agg acg tca agg        342
Asp Gly Ser Lys Leu Asn Ser Asn Ser Gly Ala Gly Arg Thr Ser Arg           
        90                  95                  100                       

cct ggt agg aca agc gac tct cca tgg ttt ctc tca ggt tct gag act        390
Pro Gly Arg Thr Ser Asp Ser Pro Trp Phe Leu Ser Gly Ser Glu Thr           
    105                 110                 115                           

cta ggc agg ctg gca ggc aac acc tta gga agc cgc tgg agt tct gga        438
Leu Gly Arg Leu Ala Gly Asn Thr Leu Gly Ser Arg Trp Ser Ser Gly           
120                 125                 130                 135           

gtg ggt gga agt ggt gga gga tcc tct ggt agg tca tca gct gga gct        486
Val Gly Gly Ser Gly Gly Gly Ser Ser Gly Arg Ser Ser Ala Gly Ala           
                140                 145                 150               

cga gat tcc cgc cgg cag act cga gtt att cgg aca gga cgg gat cga        534
Arg Asp Ser Arg Arg Gln Thr Arg Val Ile Arg Thr Gly Arg Asp Arg           
            155                 160                 165                   

ggg tct ggg ctt ttg ggc agt cag ccc cag cca gtt att cca gca tct        582
Gly Ser Gly Leu Leu Gly Ser Gln Pro Gln Pro Val Ile Pro Ala Ser           
        170                 175                 180                       

gtc att cca gag gag ctg att tca cag gcc caa gtt gtt tta caa ggc        630
Val Ile Pro Glu Glu Leu Ile Ser Gln Ala Gln Val Val Leu Gln Gly           
    185                 190                 195                           

aaa tcc aga agt gtc att att cga gaa ctt cag aga aca aat ctt gat        678
Lys Ser Arg Ser Val Ile Ile Arg Glu Leu Gln Arg Thr Asn Leu Asp           
200                 205                 210                 215           

gtg aac ctt gct gta aat aat tta ctt agc cgg gat gat gaa gat gga        726
Val Asn Leu Ala Val Asn Asn Leu Leu Ser Arg Asp Asp Glu Asp Gly           
                220                 225                 230               

gat gat ggg gat gat aca gcc agc gaa tct tat ttg cct gga gag gat        774
Asp Asp Gly Asp Asp Thr Ala Ser Glu Ser Tyr Leu Pro Gly Glu Asp           
            235                 240                 245                   

ctt atg tct ctc ctt gat gcc gac att cat tct gcc cac cca agt gtc        822
Leu Met Ser Leu Leu Asp Ala Asp Ile His Ser Ala His Pro Ser Val           
        250                 255                 260                       

att att gat gca gat gcc atg ttt tct gaa gac att agc tat ttt ggt        870
Ile Ile Asp Ala Asp Ala Met Phe Ser Glu Asp Ile Ser Tyr Phe Gly           
    265                 270                 275                           

tac cct tct ttt cgt cgt tca tca ctt tcc agg cta ggc tca tct cga        918
Tyr Pro Ser Phe Arg Arg Ser Ser Leu Ser Arg Leu Gly Ser Ser Arg           
280                 285                 290                 295           

gtt ctc ctt ctt ccc tta gag aga gac tct gag ctg ttg cgt gaa cgt        966
Val Leu Leu Leu Pro Leu Glu Arg Asp Ser Glu Leu Leu Arg Glu Arg           
                300                 305                 310               

gaa tcc gtt tta cgt tta cgt gaa cga agg tgg ctt gat gga gcc tca       1014
Glu Ser Val Leu Arg Leu Arg Glu Arg Arg Trp Leu Asp Gly Ala Ser           
            315                 320                 325                   

ttt gat aat gaa agg ggt tct acc agc aag gaa gga gag cca aac ttg       1062
Phe Asp Asn Glu Arg Gly Ser Thr Ser Lys Glu Gly Glu Pro Asn Leu           
        330                 335                 340                       

gat aag aag aat aca cct gtt caa agt cca gta tct cta gga gaa gat       1110
Asp Lys Lys Asn Thr Pro Val Gln Ser Pro Val Ser Leu Gly Glu Asp           
    345                 350                 355                           

ttg cag tgg tgg cct gat aag gat gga aca aaa ttc atc tgt att ggg       1158
Leu Gln Trp Trp Pro Asp Lys Asp Gly Thr Lys Phe Ile Cys Ile Gly           
360                 365                 370                 375           

gct ctg tat tct gaa ctt ctg gct gtc agc agt aaa gga gaa ctt tat       1206
Ala Leu Tyr Ser Glu Leu Leu Ala Val Ser Ser Lys Gly Glu Leu Tyr           
                380                 385                 390               

cag tgg aaa tgg agt gaa tct gag cct tac aga aat gcc cag aat cct       1254
Gln Trp Lys Trp Ser Glu Ser Glu Pro Tyr Arg Asn Ala Gln Asn Pro           
            395                 400                 405                   

tca tta cat cat cca cga gca aca ttt ttg ggg tta acc aat gaa aag       1302
Ser Leu His His Pro Arg Ala Thr Phe Leu Gly Leu Thr Asn Glu Lys           
        410                 415                 420                       

ata gtc ctc ctg tct gca aat agc ata aga gca act gta gct aca gaa       1350
Ile Val Leu Leu Ser Ala Asn Ser Ile Arg Ala Thr Val Ala Thr Glu           
    425                 430                 435                           

aat aac aag gtt gct aca tgg gtg gat gaa act tta agt tct gtg gct       1398
Asn Asn Lys Val Ala Thr Trp Val Asp Glu Thr Leu Ser Ser Val Ala           
440                 445                 450                 455           

tct aaa tta gag cac act gct cag act tac tct gaa ctt caa gga gag       1446
Ser Lys Leu Glu His Thr Ala Gln Thr Tyr Ser Glu Leu Gln Gly Glu           
                460                 465                 470               

cgg ata gtt tct tta cat tgc tgt gcc ctt tac acc tgc gct cag ctg       1494
Arg Ile Val Ser Leu His Cys Cys Ala Leu Tyr Thr Cys Ala Gln Leu           
            475                 480                 485                   

gaa aac agt tta tat tgg tgg ggt gta gtt cct ttt agt caa agg aag       1542
Glu Asn Ser Leu Tyr Trp Trp Gly Val Val Pro Phe Ser Gln Arg Lys           
        490                 495                 500                       

aaa atg tta gag aaa gct aga gca aaa aat aaa aag cct aaa tcc agt       1590
Lys Met Leu Glu Lys Ala Arg Ala Lys Asn Lys Lys Pro Lys Ser Ser           
    505                 510                 515                           

gct ggt att tct tca atg ccg aac atc act gtt ggt acc cag gta tgc       1638
Ala Gly Ile Ser Ser Met Pro Asn Ile Thr Val Gly Thr Gln Val Cys           
520                 525                 530                 535           

ttg aga aat aat cct ctt tat cat gct gga gca gtt gca ttt tca att       1686
Leu Arg Asn Asn Pro Leu Tyr His Ala Gly Ala Val Ala Phe Ser Ile           
                540                 545                 550               

agt gct ggg att cct aaa gtt ggt gtc tta atg gag tca gtt tgg aat       1734
Ser Ala Gly Ile Pro Lys Val Gly Val Leu Met Glu Ser Val Trp Asn           
            555                 560                 565                   

atg aat gac agc tgt aga ttt caa ctt aga tct cct gaa agc ttg aaa       1782
Met Asn Asp Ser Cys Arg Phe Gln Leu Arg Ser Pro Glu Ser Leu Lys           
        570                 575                 580                       

aac atg gaa aaa gct agc aaa act act gaa gct aag cct gaa agt aag       1830
Asn Met Glu Lys Ala Ser Lys Thr Thr Glu Ala Lys Pro Glu Ser Lys           
    585                 590                 595                           

cag gag cca gtg aaa aca gaa atg ggt cct cca cca tct cca gca tcc       1878
Gln Glu Pro Val Lys Thr Glu Met Gly Pro Pro Pro Ser Pro Ala Ser           
600                 605                 610                 615           

acg tgt agt gat gca tcc tca att gcc agc agt gca tca atg cca tac       1926
Thr Cys Ser Asp Ala Ser Ser Ile Ala Ser Ser Ala Ser Met Pro Tyr           
                620                 625                 630               

aaa cga cga cgg tca acc cct gca cca aaa gaa gag gaa aag gtg aat       1974
Lys Arg Arg Arg Ser Thr Pro Ala Pro Lys Glu Glu Glu Lys Val Asn           
            635                 640                 645                   

gaa gag cag tgg tct ctt cgg gaa gtg gtt ttt gtg gaa gat gtc aag       2022
Glu Glu Gln Trp Ser Leu Arg Glu Val Val Phe Val Glu Asp Val Lys           
        650                 655                 660                       

aat gtt cct gtt ggc aag gtg cta aaa gta gat ggt gcc tat gtt gct       2070
Asn Val Pro Val Gly Lys Val Leu Lys Val Asp Gly Ala Tyr Val Ala           
    665                 670                 675                           

gta aaa ttt cca gga acc tcc agt aat act aac tgt cag aac agc tct       2118
Val Lys Phe Pro Gly Thr Ser Ser Asn Thr Asn Cys Gln Asn Ser Ser           
680                 685                 690                 695           

ggt cca gat gct gac cct tct tct ctc ctg cag gat tgt agg tta ctt       2166
Gly Pro Asp Ala Asp Pro Ser Ser Leu Leu Gln Asp Cys Arg Leu Leu           
                700                 705                 710               

aga att gat gaa ttg cag gtt gtc aaa act ggt gga aca ccg aag gtt       2214
Arg Ile Asp Glu Leu Gln Val Val Lys Thr Gly Gly Thr Pro Lys Val           
            715                 720                 725                   

ccc gac tgt ttc caa agg act cct aaa aag ctt tgt ata cct gaa aaa       2262
Pro Asp Cys Phe Gln Arg Thr Pro Lys Lys Leu Cys Ile Pro Glu Lys           
        730                 735                 740                       

aca gaa ata tta gca gtg aat gta gat tcc aaa ggt gtt cat gct gtt       2310
Thr Glu Ile Leu Ala Val Asn Val Asp Ser Lys Gly Val His Ala Val           
    745                 750                 755                           

ctg aag act gga aat tgg gta cga tac tgt atc ttt gat ctt gct aca       2358
Leu Lys Thr Gly Asn Trp Val Arg Tyr Cys Ile Phe Asp Leu Ala Thr           
760                 765                 770                 775           

gga aaa gca gaa cag gaa aat aat ttt cct aca agc agc att gct ttc       2406
Gly Lys Ala Glu Gln Glu Asn Asn Phe Pro Thr Ser Ser Ile Ala Phe           
                780                 785                 790               

ctt ggt cag aat gag agg aat gta gcc att ttc act gct gga cag gaa       2454
Leu Gly Gln Asn Glu Arg Asn Val Ala Ile Phe Thr Ala Gly Gln Glu           
            795                 800                 805                   

tct ccc att att ctt cga gat gga aat ggt acc atc tac cca atg gcc       2502
Ser Pro Ile Ile Leu Arg Asp Gly Asn Gly Thr Ile Tyr Pro Met Ala           
        810                 815                 820                       

aaa gat tgc atg gga gga ata agg gat ccc gat tgg ctg gat ctt cca       2550
Lys Asp Cys Met Gly Gly Ile Arg Asp Pro Asp Trp Leu Asp Leu Pro           
    825                 830                 835                           

cct att agt agt ctt gga atg ggt gtg cat tct tta ata aat ctt cct       2598
Pro Ile Ser Ser Leu Gly Met Gly Val His Ser Leu Ile Asn Leu Pro           
840                 845                 850                 855           

gcc aat tca aca atc aaa aag aaa gct gct gtt atc atc atg gct gta       2646
Ala Asn Ser Thr Ile Lys Lys Lys Ala Ala Val Ile Ile Met Ala Val           
                860                 865                 870               

gag aaa caa acc tta atg caa cac att ctg cgc tgt gac tat gag gcc       2694
Glu Lys Gln Thr Leu Met Gln His Ile Leu Arg Cys Asp Tyr Glu Ala           
            875                 880                 885                   

tgt cga caa tat cta atg aat ctt gag caa gcg gtt gtt tta gag cag       2742
Cys Arg Gln Tyr Leu Met Asn Leu Glu Gln Ala Val Val Leu Glu Gln           
        890                 895                 900                       

aat cta cag atg ctg cag aca ttc atc agc cac aga tgt gat gga aat       2790
Asn Leu Gln Met Leu Gln Thr Phe Ile Ser His Arg Cys Asp Gly Asn           
    905                 910                 915                           

cga aat att ttg cat gct tgt gta tca gtt tgc ttt cca acc agc aat       2838
Arg Asn Ile Leu His Ala Cys Val Ser Val Cys Phe Pro Thr Ser Asn           
920                 925                 930                 935           

aaa gaa act aaa gaa gaa gag gaa gcg gag cgt tct gaa aga aat aca       2886
Lys Glu Thr Lys Glu Glu Glu Glu Ala Glu Arg Ser Glu Arg Asn Thr           
                940                 945                 950               

ttt gca gaa agg ctt tct gct gtt gag gcc att gca aat gca ata tca       2934
Phe Ala Glu Arg Leu Ser Ala Val Glu Ala Ile Ala Asn Ala Ile Ser           
            955                 960                 965                   

gtt gtt tca agt aat ggc cca ggt aat cgg gct gga tca tca agt agc       2982
Val Val Ser Ser Asn Gly Pro Gly Asn Arg Ala Gly Ser Ser Ser Ser           
        970                 975                 980                       

cga agt ttg aga tta cgg gaa atg atg aga cgt tcg ttg aga gca gct       3030
Arg Ser Leu Arg Leu Arg Glu Met Met Arg Arg Ser Leu Arg Ala Ala           
    985                 990                 995                           

ggt  ttg ggt aga cat gaa  gct gga gct tca tcc  agt gac cac cag        3075
Gly  Leu Gly Arg His Glu  Ala Gly Ala Ser Ser  Ser Asp His Gln            
1000                 1005                 1010                            

gat  cca gtt tca ccc ccc  ata gct ccc cct agt  tgg gtt cct gac        3120
Asp  Pro Val Ser Pro Pro  Ile Ala Pro Pro Ser  Trp Val Pro Asp            
1015                 1020                 1025                            

cct  cct gcg atg gat cct  gat ggt gac att gat  ttt atc ctg gcc        3165
Pro  Pro Ala Met Asp Pro  Asp Gly Asp Ile Asp  Phe Ile Leu Ala            
1030                 1035                 1040                            

ccc  gct gtg gga tct ctt  acc aca gca gca acc  ggt act ggt caa        3210
Pro  Ala Val Gly Ser Leu  Thr Thr Ala Ala Thr  Gly Thr Gly Gln            
1045                 1050                 1055                            

gga  cca agc acc tcc act  att cca ggt cct tcc  aca gag cca tct        3255
Gly  Pro Ser Thr Ser Thr  Ile Pro Gly Pro Ser  Thr Glu Pro Ser            
1060                 1065                 1070                            

gta  gta gaa tcc aag gat  cga aag gcg aat gct  cat ttt ata ttg        3300
Val  Val Glu Ser Lys Asp  Arg Lys Ala Asn Ala  His Phe Ile Leu            
1075                 1080                 1085                            

aaa  ttg tta tgt gac agt  gtg gtt ctc cag ccc  tat cta cga gaa        3345
Lys  Leu Leu Cys Asp Ser  Val Val Leu Gln Pro  Tyr Leu Arg Glu            
1090                 1095                 1100                            

ctt  ctt tct gcc aag gat  gca aga ggg atg acc  cca ttt atg tca        3390
Leu  Leu Ser Ala Lys Asp  Ala Arg Gly Met Thr  Pro Phe Met Ser            
1105                 1110                 1115                            

gct  gta agt ggc cga gct  tat cct gct gca att  acc atc tta gaa        3435
Ala  Val Ser Gly Arg Ala  Tyr Pro Ala Ala Ile  Thr Ile Leu Glu            
1120                 1125                 1130                            

act  gct cag aaa att gca  aaa gct gaa ata tcc  tca agt gaa aaa        3480
Thr  Ala Gln Lys Ile Ala  Lys Ala Glu Ile Ser  Ser Ser Glu Lys            
1135                 1140                 1145                            

gag  gaa gat gta ttc atg  gga atg gtt tgc cca  tca ggt acc aac        3525
Glu  Glu Asp Val Phe Met  Gly Met Val Cys Pro  Ser Gly Thr Asn            
1150                 1155                 1160                            

cct  gat gac tct cct tta  tat gtt tta tgt tgt  aat gac act tgc        3570
Pro  Asp Asp Ser Pro Leu  Tyr Val Leu Cys Cys  Asn Asp Thr Cys            
1165                 1170                 1175                            

agt  ttt aca tgg act gga  gca gag cac att aac  cag gat att ttt        3615
Ser  Phe Thr Trp Thr Gly  Ala Glu His Ile Asn  Gln Asp Ile Phe            
1180                 1185                 1190                            

gag  tgt cga act tgt ggc  ttg ctg gag tca ctg  tgt tgt tgt acg        3660
Glu  Cys Arg Thr Cys Gly  Leu Leu Glu Ser Leu  Cys Cys Cys Thr            
1195                 1200                 1205                            

gaa  tgt gca agg gtt tgt  cat aaa ggt cat gat  tgc aaa ctc aaa        3705
Glu  Cys Ala Arg Val Cys  His Lys Gly His Asp  Cys Lys Leu Lys            
1210                 1215                 1220                            

cgg  aca tca cca aca gcc  tac tgt gat tgt tgg  gag aaa tgt aaa        3750
Arg  Thr Ser Pro Thr Ala  Tyr Cys Asp Cys Trp  Glu Lys Cys Lys            
1225                 1230                 1235                            

tgt  aaa act ctt att gct  gga cag aaa tct gct  cgt ctt gat cta        3795
Cys  Lys Thr Leu Ile Ala  Gly Gln Lys Ser Ala  Arg Leu Asp Leu            
1240                 1245                 1250                            

ctt  tat cgc ctg ctc act  gct act aat ctg gtt  act ctg cca aac        3840
Leu  Tyr Arg Leu Leu Thr  Ala Thr Asn Leu Val  Thr Leu Pro Asn            
1255                 1260                 1265                            

agc  agg gga gag cac ctc  tta cta ttc tta gta  cag aca gtc gca        3885
Ser  Arg Gly Glu His Leu  Leu Leu Phe Leu Val  Gln Thr Val Ala            
1270                 1275                 1280                            

agg  cag acg gtg gag cat  tgt caa tac agg cca  cct cga atc agg        3930
Arg  Gln Thr Val Glu His  Cys Gln Tyr Arg Pro  Pro Arg Ile Arg            
1285                 1290                 1295                            

gaa  gat cgt aac cga aaa  aca gcc agt cct gaa  gat tca gat atg        3975
Glu  Asp Arg Asn Arg Lys  Thr Ala Ser Pro Glu  Asp Ser Asp Met            
1300                 1305                 1310                            

cca  gat cat gat tta gag  cct cca aga ttt gcc  cag ctt gca ttg        4020
Pro  Asp His Asp Leu Glu  Pro Pro Arg Phe Ala  Gln Leu Ala Leu            
1315                 1320                 1325                            

gag  cgt gtt cta cag gac  tgg aat gcc ttg aaa  tct atg att atg        4065
Glu  Arg Val Leu Gln Asp  Trp Asn Ala Leu Lys  Ser Met Ile Met            
1330                 1335                 1340                            

ttt  ggg tcg cag gag aat  aaa gac cct ctt agt  gcc agc agt aga        4110
Phe  Gly Ser Gln Glu Asn  Lys Asp Pro Leu Ser  Ala Ser Ser Arg            
1345                 1350                 1355                            

ata  ggc cat ctt ttg cca  gaa gag caa gta tac  ctc aat cag caa        4155
Ile  Gly His Leu Leu Pro  Glu Glu Gln Val Tyr  Leu Asn Gln Gln            
1360                 1365                 1370                            

agt  ggc aca att cgg ctg  gac tgt ttc act cat  tgc ctt ata gtt        4200
Ser  Gly Thr Ile Arg Leu  Asp Cys Phe Thr His  Cys Leu Ile Val            
1375                 1380                 1385                            

aag  tgt aca gca gat att  ttg ctt tta gat act  cta cta ggt aca        4245
Lys  Cys Thr Ala Asp Ile  Leu Leu Leu Asp Thr  Leu Leu Gly Thr            
1390                 1395                 1400                            

cta  gtg aaa gaa ctc caa  aac aaa tat aca cct  gga cgt aga gaa        4290
Leu  Val Lys Glu Leu Gln  Asn Lys Tyr Thr Pro  Gly Arg Arg Glu            
1405                 1410                 1415                            

gaa  gct att gct gtg aca  atg agg ttt cta cgt  tca gtg gca aga        4335
Glu  Ala Ile Ala Val Thr  Met Arg Phe Leu Arg  Ser Val Ala Arg            
1420                 1425                 1430                            

gtt  ttt gtt att ctg agt  gtg gaa atg gct tca  tcc aaa aag aaa        4380
Val  Phe Val Ile Leu Ser  Val Glu Met Ala Ser  Ser Lys Lys Lys            
1435                 1440                 1445                            

aac  aac ttt att cca cag  cca att gga aaa tgc  aag cgt gta ttc        4425
Asn  Asn Phe Ile Pro Gln  Pro Ile Gly Lys Cys  Lys Arg Val Phe            
1450                 1455                 1460                            

caa  gca ttg cta cct tac  gct gtg gaa gaa ttg  tgc aac gta gca        4470
Gln  Ala Leu Leu Pro Tyr  Ala Val Glu Glu Leu  Cys Asn Val Ala            
1465                 1470                 1475                            

gag  tca ctg att gtt cct  gtc aga atg ggg att  gct cgt cca act        4515
Glu  Ser Leu Ile Val Pro  Val Arg Met Gly Ile  Ala Arg Pro Thr            
1480                 1485                 1490                            

gca  cca ttt acc ctg gct  agt act agc ata gat  gcc atg cag ggc        4560
Ala  Pro Phe Thr Leu Ala  Ser Thr Ser Ile Asp  Ala Met Gln Gly            
1495                 1500                 1505                            

agt  gaa gaa tta ttt tca  gtg gaa cca cta cca  cca cga cca tca        4605
Ser  Glu Glu Leu Phe Ser  Val Glu Pro Leu Pro  Pro Arg Pro Ser            
1510                 1515                 1520                            

tct  gat cag tct agc agc  tcc agt cag tct cag  tca tcc tac atc        4650
Ser  Asp Gln Ser Ser Ser  Ser Ser Gln Ser Gln  Ser Ser Tyr Ile            
1525                 1530                 1535                            

atc  agg aat cca cag cag  agg cgc atc agc cag  tca cag ccc gtt        4695
Ile  Arg Asn Pro Gln Gln  Arg Arg Ile Ser Gln  Ser Gln Pro Val            
1540                 1545                 1550                            

cgg  ggc aga gat gaa gaa  cag gat gat att gtt  tca gca gat gtg        4740
Arg  Gly Arg Asp Glu Glu  Gln Asp Asp Ile Val  Ser Ala Asp Val            
1555                 1560                 1565                            

gaa  gag gtt gag gtg gtg  gag ggt gtg gct gga  gaa gag gat cat        4785
Glu  Glu Val Glu Val Val  Glu Gly Val Ala Gly  Glu Glu Asp His            
1570                 1575                 1580                            

cat  gat gaa cag gaa gaa  cac ggg gaa gaa aat  gct gag gca gag        4830
His  Asp Glu Gln Glu Glu  His Gly Glu Glu Asn  Ala Glu Ala Glu            
1585                 1590                 1595                            

gga  caa cat gat gag cat  gat gaa gac ggg agt  gat atg gag ctg        4875
Gly  Gln His Asp Glu His  Asp Glu Asp Gly Ser  Asp Met Glu Leu            
1600                 1605                 1610                            

gac  ttg tta gca gca gct  gaa aca gaa agt gat  agt gaa agt aac        4920
Asp  Leu Leu Ala Ala Ala  Glu Thr Glu Ser Asp  Ser Glu Ser Asn            
1615                 1620                 1625                            

cac  agc aac caa gat aat  gct agt ggg cgc aga  agc gtt gtc act        4965
His  Ser Asn Gln Asp Asn  Ala Ser Gly Arg Arg  Ser Val Val Thr            
1630                 1635                 1640                            

gca  gca act gct ggt tca  gaa gca gga gca agc  agt gtt cct gcc        5010
Ala  Ala Thr Ala Gly Ser  Glu Ala Gly Ala Ser  Ser Val Pro Ala            
1645                 1650                 1655                            

ttc  ttt tct gaa gat gat  tct caa tcg aat gac  tca agt gat tct        5055
Phe  Phe Ser Glu Asp Asp  Ser Gln Ser Asn Asp  Ser Ser Asp Ser            
1660                 1665                 1670                            

gat  agc agt agt agt cag  agt gac gac ata gaa  cag gag acc ttt        5100
Asp  Ser Ser Ser Ser Gln  Ser Asp Asp Ile Glu  Gln Glu Thr Phe            
1675                 1680                 1685                            

atg  ctt gat gag cca tta  gaa aga acc aca aat  agc tcc cat gcc        5145
Met  Leu Asp Glu Pro Leu  Glu Arg Thr Thr Asn  Ser Ser His Ala            
1690                 1695                 1700                            

aat  ggt gct gcc caa gct  ccc cgt tca atg cag  tgg gct gtc cgc        5190
Asn  Gly Ala Ala Gln Ala  Pro Arg Ser Met Gln  Trp Ala Val Arg            
1705                 1710                 1715                            

aac  acc cag cat cag cga  gca gcc agt aca gcc  cct tcc agt aca        5235
Asn  Thr Gln His Gln Arg  Ala Ala Ser Thr Ala  Pro Ser Ser Thr            
1720                 1725                 1730                            

tct  aca cca gca gca agt  tca gcg ggt ttg att  tat att gat cct        5280
Ser  Thr Pro Ala Ala Ser  Ser Ala Gly Leu Ile  Tyr Ile Asp Pro            
1735                 1740                 1745                            

tca  aac tta cgc cgg agt  ggt acc atc agt aca  agt gct gca gct        5325
Ser  Asn Leu Arg Arg Ser  Gly Thr Ile Ser Thr  Ser Ala Ala Ala            
1750                 1755                 1760                            

gca  gca gct gct ttg gaa  gct agc aac gcc agc  agt tac cta aca        5370
Ala  Ala Ala Ala Leu Glu  Ala Ser Asn Ala Ser  Ser Tyr Leu Thr            
1765                 1770                 1775                            

tct  gca agc agt tta gcc  agg gct tac agc att  gtc att aga caa        5415
Ser  Ala Ser Ser Leu Ala  Arg Ala Tyr Ser Ile  Val Ile Arg Gln            
1780                 1785                 1790                            

atc  tcg gac ttg atg ggc  ctt att cct aag tat  aat cac cta gta        5460
Ile  Ser Asp Leu Met Gly  Leu Ile Pro Lys Tyr  Asn His Leu Val            
1795                 1800                 1805                            

tac  tct cag att cca gca  gct gtg aaa ttg act  tac caa gat gca        5505
Tyr  Ser Gln Ile Pro Ala  Ala Val Lys Leu Thr  Tyr Gln Asp Ala            
1810                 1815                 1820                            

gta  aac tta cag aac tat  gta gaa gaa aag ctt  att ccc act tgg        5550
Val  Asn Leu Gln Asn Tyr  Val Glu Glu Lys Leu  Ile Pro Thr Trp            
1825                 1830                 1835                            

aac  tgg atg gtc agt att  atg gat tct act gaa  gct caa tta cgt        5595
Asn  Trp Met Val Ser Ile  Met Asp Ser Thr Glu  Ala Gln Leu Arg            
1840                 1845                 1850                            

tat  ggt tct gca tta gca  tct gct ggt gat cct  gga cat cca aat        5640
Tyr  Gly Ser Ala Leu Ala  Ser Ala Gly Asp Pro  Gly His Pro Asn            
1855                 1860                 1865                            

cat  cct ctt cac gct tct  cag aat tca gcg aga  aga gag agg atg        5685
His  Pro Leu His Ala Ser  Gln Asn Ser Ala Arg  Arg Glu Arg Met            
1870                 1875                 1880                            

act  gcg cga gaa gaa gct  agc tta cga aca ctt  gaa ggc aga cga        5730
Thr  Ala Arg Glu Glu Ala  Ser Leu Arg Thr Leu  Glu Gly Arg Arg            
1885                 1890                 1895                            

cgt  gcc acc ttg ctt agc  gcc cgt caa gga atg  atg tct gca cga        5775
Arg  Ala Thr Leu Leu Ser  Ala Arg Gln Gly Met  Met Ser Ala Arg            
1900                 1905                 1910                            

gga  gac ttc cta aat tat  gct ctg tct cta atg  cgg tct cat aat        5820
Gly  Asp Phe Leu Asn Tyr  Ala Leu Ser Leu Met  Arg Ser His Asn            
1915                 1920                 1925                            

gat  gag cat tct gat gtt  ctt cca gtt ttg gat  gtt tgc tca ttg        5865
Asp  Glu His Ser Asp Val  Leu Pro Val Leu Asp  Val Cys Ser Leu            
1930                 1935                 1940                            

aag  cat gtg gca tat gtt  ttt caa gca ctt ata  tac tgg att aag        5910
Lys  His Val Ala Tyr Val  Phe Gln Ala Leu Ile  Tyr Trp Ile Lys            
1945                 1950                 1955                            

gca  atg aat cag cag aca  aca ttg gat aca cct  caa cta gaa cgc        5955
Ala  Met Asn Gln Gln Thr  Thr Leu Asp Thr Pro  Gln Leu Glu Arg            
1960                 1965                 1970                            

aaa  agg acg cga gaa ctc  ttg gaa ctg ggt att  gat aat gaa gat        6000
Lys  Arg Thr Arg Glu Leu  Leu Glu Leu Gly Ile  Asp Asn Glu Asp            
1975                 1980                 1985                            

tca  gaa cat gaa aat gat  gat gac acc aat caa  agt gct act ttg        6045
Ser  Glu His Glu Asn Asp  Asp Asp Thr Asn Gln  Ser Ala Thr Leu            
1990                 1995                 2000                            

aat  gat aag gat gat gac  tct ctt cct gca gaa  act ggc caa aac        6090
Asn  Asp Lys Asp Asp Asp  Ser Leu Pro Ala Glu  Thr Gly Gln Asn            
2005                 2010                 2015                            

cat  cca ttt ttc cga cgt  tca gac tcc atg aca  ttc ctt ggg tgt        6135
His  Pro Phe Phe Arg Arg  Ser Asp Ser Met Thr  Phe Leu Gly Cys            
2020                 2025                 2030                            

ata  ccc cca aat cca ttt  gaa gtg cct ctg gct  gaa gcc atc ccc        6180
Ile  Pro Pro Asn Pro Phe  Glu Val Pro Leu Ala  Glu Ala Ile Pro            
2035                 2040                 2045                            

ttg  gct gat cag cca cat  ctg ttg cag cca aat  gct aga aag gag        6225
Leu  Ala Asp Gln Pro His  Leu Leu Gln Pro Asn  Ala Arg Lys Glu            
2050                 2055                 2060                            

gat  ctt ttt ggc cgt cca  agt cag ggt ctt tat  tct tca tct gcc        6270
Asp  Leu Phe Gly Arg Pro  Ser Gln Gly Leu Tyr  Ser Ser Ser Ala            
2065                 2070                 2075                            

agt  agt ggg aaa tgt tta  atg gag gtt aca gtg  gat aga aac tgc        6315
Ser  Ser Gly Lys Cys Leu  Met Glu Val Thr Val  Asp Arg Asn Cys            
2080                 2085                 2090                            

cta  gag gtt ctt cca aca  aaa atg tct tat gct  gcc aat ctg aaa        6360
Leu  Glu Val Leu Pro Thr  Lys Met Ser Tyr Ala  Ala Asn Leu Lys            
2095                 2100                 2105                            

aat  gta atg aac atg caa  aac cgg caa aaa aaa  gaa ggg gaa gaa        6405
Asn  Val Met Asn Met Gln  Asn Arg Gln Lys Lys  Glu Gly Glu Glu            
2110                 2115                 2120                            

cag  ccc gtg ctg cca gaa  gaa act gag agt tca  aaa cca ggg cca        6450
Gln  Pro Val Leu Pro Glu  Glu Thr Glu Ser Ser  Lys Pro Gly Pro            
2125                 2130                 2135                            

tct  gct cat gat ctt gct  gca caa tta aaa agt  agc tta cta gca        6495
Ser  Ala His Asp Leu Ala  Ala Gln Leu Lys Ser  Ser Leu Leu Ala            
2140                 2145                 2150                            

gaa  ata gga ctt act gaa  agt gaa ggg cca cct  ctc aca tct ttc        6540
Glu  Ile Gly Leu Thr Glu  Ser Glu Gly Pro Pro  Leu Thr Ser Phe            
2155                 2160                 2165                            

agg  cca cag tgt agc ttt  atg gga atg gtt att  tcc cat gat atg        6585
Arg  Pro Gln Cys Ser Phe  Met Gly Met Val Ile  Ser His Asp Met            
2170                 2175                 2180                            

ctg  cta gga cgt tgg cgc  ctt tct tta gaa ctg  ttc ggc agg gta        6630
Leu  Leu Gly Arg Trp Arg  Leu Ser Leu Glu Leu  Phe Gly Arg Val            
2185                 2190                 2195                            

ttc  atg gaa gat gtt gga  gca gaa cct gga tca  atc cta act gaa        6675
Phe  Met Glu Asp Val Gly  Ala Glu Pro Gly Ser  Ile Leu Thr Glu            
2200                 2205                 2210                            

ttg  ggt ggt ttt gag gta  aaa gaa tca aaa ttc  cgc aga gaa atg        6720
Leu  Gly Gly Phe Glu Val  Lys Glu Ser Lys Phe  Arg Arg Glu Met            
2215                 2220                 2225                            

gaa  aaa ctg aga aac cag  cag tca aga gat ttg  tca cta gag gtt        6765
Glu  Lys Leu Arg Asn Gln  Gln Ser Arg Asp Leu  Ser Leu Glu Val            
2230                 2235                 2240                            

gat  cgg gat cga gat ctt  ctc att cag cag act  atg agg cag ctt        6810
Asp  Arg Asp Arg Asp Leu  Leu Ile Gln Gln Thr  Met Arg Gln Leu            
2245                 2250                 2255                            

aac  aat cac ttt ggt cga  aga tgt gct act aca  cca atg gct gta        6855
Asn  Asn His Phe Gly Arg  Arg Cys Ala Thr Thr  Pro Met Ala Val            
2260                 2265                 2270                            

cac  aga gta aaa gtc aca  ttt aag gat gag cca  gga gag ggc agt        6900
His  Arg Val Lys Val Thr  Phe Lys Asp Glu Pro  Gly Glu Gly Ser            
2275                 2280                 2285                            

ggt  gta gca cga agt ttt  tat aca gcc att gca  caa gca ttt tta        6945
Gly  Val Ala Arg Ser Phe  Tyr Thr Ala Ile Ala  Gln Ala Phe Leu            
2290                 2295                 2300                            

tca  aat gaa aaa ttg cca  aat cta gag tgt atc  caa aat gcc aac        6990
Ser  Asn Glu Lys Leu Pro  Asn Leu Glu Cys Ile  Gln Asn Ala Asn            
2305                 2310                 2315                            

aaa  ggc acc cac aca agt  tta atg cag aga tta  agg aac cga gga        7035
Lys  Gly Thr His Thr Ser  Leu Met Gln Arg Leu  Arg Asn Arg Gly            
2320                 2325                 2330                            

gag  aga gac cgg gaa agg  gag aga gaa agg gaa  atg agg agg agt        7080
Glu  Arg Asp Arg Glu Arg  Glu Arg Glu Arg Glu  Met Arg Arg Ser            
2335                 2340                 2345                            

agt  ggt ttg cga gca ggt  tct cgg agg gac cgg  gat aga gac ttt        7125
Ser  Gly Leu Arg Ala Gly  Ser Arg Arg Asp Arg  Asp Arg Asp Phe            
2350                 2355                 2360                            

aga  aga cag ctt tcc atc  gac act agg ccc ttt  aga cca gcc tct        7170
Arg  Arg Gln Leu Ser Ile  Asp Thr Arg Pro Phe  Arg Pro Ala Ser            
2365                 2370                 2375                            

gaa  ggg aat cct agc gat  gat cct gag cct ttg  cca gca cat cgg        7215
Glu  Gly Asn Pro Ser Asp  Asp Pro Glu Pro Leu  Pro Ala His Arg            
2380                 2385                 2390                            

cag  gca ctt gga gag agg  ctt tat cct cgt gta  caa gca atg caa        7260
Gln  Ala Leu Gly Glu Arg  Leu Tyr Pro Arg Val  Gln Ala Met Gln            
2395                 2400                 2405                            

cca  gca ttt gca agt aaa  atc act ggc atg ttg  ttg gaa tta tcc        7305
Pro  Ala Phe Ala Ser Lys  Ile Thr Gly Met Leu  Leu Glu Leu Ser            
2410                 2415                 2420                            

cca  gct cag ctg ctt ctc  ctt cta gca agt gag  gat tct ctg aga        7350
Pro  Ala Gln Leu Leu Leu  Leu Leu Ala Ser Glu  Asp Ser Leu Arg            
2425                 2430                 2435                            

gca  aga gtg gat gag gcc  atg gaa ctc att att  gca cat gga cgg        7395
Ala  Arg Val Asp Glu Ala  Met Glu Leu Ile Ile  Ala His Gly Arg            
2440                 2445                 2450                            

gaa  aat gga gct gat agt  atc ctg gat ctt gga  tta gta gac tcc        7440
Glu  Asn Gly Ala Asp Ser  Ile Leu Asp Leu Gly  Leu Val Asp Ser            
2455                 2460                 2465                            

tca  gaa aag gta cag cag  gaa aac cga aag cgc  cat ggc tct agt        7485
Ser  Glu Lys Val Gln Gln  Glu Asn Arg Lys Arg  His Gly Ser Ser            
2470                 2475                 2480                            

cga  agt gta gta gat atg  gat tta gat gat aca  gat gat ggt gat        7530
Arg  Ser Val Val Asp Met  Asp Leu Asp Asp Thr  Asp Asp Gly Asp            
2485                 2490                 2495                            

gac  aat gcc cct ttg ttt  tac caa cct ggg aaa  aga gga ttt tat        7575
Asp  Asn Ala Pro Leu Phe  Tyr Gln Pro Gly Lys  Arg Gly Phe Tyr            
2500                 2505                 2510                            

act  cca agg cct ggc aag  aac aca gaa gca agg  ttg aat tgt ttc        7620
Thr  Pro Arg Pro Gly Lys  Asn Thr Glu Ala Arg  Leu Asn Cys Phe            
2515                 2520                 2525                            

aga  aac att ggc agg att  ctt gga cta tgt ctg  tta cag aat gaa        7665
Arg  Asn Ile Gly Arg Ile  Leu Gly Leu Cys Leu  Leu Gln Asn Glu            
2530                 2535                 2540                            

cta  tgt cct atc aca ttg  aat aga cat gta att  aaa gta ttg ctt        7710
Leu  Cys Pro Ile Thr Leu  Asn Arg His Val Ile  Lys Val Leu Leu            
2545                 2550                 2555                            

ggt  aga aaa gtc aat tgg  cat gat ttt gct ttt  ttt gat cct gta        7755
Gly  Arg Lys Val Asn Trp  His Asp Phe Ala Phe  Phe Asp Pro Val            
2560                 2565                 2570                            

atg  tat gag agt ttg cgg  caa cta atc ctc gcg  tct cag agt tca        7800
Met  Tyr Glu Ser Leu Arg  Gln Leu Ile Leu Ala  Ser Gln Ser Ser            
2575                 2580                 2585                            

gat  gct gat gct gtt ttc  tca gca atg gat ttg  gca ttt gca att        7845
Asp  Ala Asp Ala Val Phe  Ser Ala Met Asp Leu  Ala Phe Ala Ile            
2590                 2595                 2600                            

gac  ctg tgt aaa gaa gaa  ggt gga gga cag gtt  gaa ctc att cct        7890
Asp  Leu Cys Lys Glu Glu  Gly Gly Gly Gln Val  Glu Leu Ile Pro            
2605                 2610                 2615                            

aat  ggt gta aat ata cca  gtc act cca cag aat  gta tat gag tat        7935
Asn  Gly Val Asn Ile Pro  Val Thr Pro Gln Asn  Val Tyr Glu Tyr            
2620                 2625                 2630                            

gtg  cgg aaa tac gca gaa  cac aga atg ttg gta  gtt gca gaa cag        7980
Val  Arg Lys Tyr Ala Glu  His Arg Met Leu Val  Val Ala Glu Gln            
2635                 2640                 2645                            

ccc  tta cat gca atg agg  aaa ggt cta cta gat  gtg ctt cca aaa        8025
Pro  Leu His Ala Met Arg  Lys Gly Leu Leu Asp  Val Leu Pro Lys            
2650                 2655                 2660                            

aat  tca tta gaa gat tta  acg gca gaa gat ttt  agg ctt ttg gta        8070
Asn  Ser Leu Glu Asp Leu  Thr Ala Glu Asp Phe  Arg Leu Leu Val            
2665                 2670                 2675                            

aat  ggc tgc ggt gaa gtc  aat gtg caa atg ctg  atc agt ttt acc        8115
Asn  Gly Cys Gly Glu Val  Asn Val Gln Met Leu  Ile Ser Phe Thr            
2680                 2685                 2690                            

tct  ttc aat gat gaa tca  gga gaa aat gct gag  aag ctt ctg cag        8160
Ser  Phe Asn Asp Glu Ser  Gly Glu Asn Ala Glu  Lys Leu Leu Gln            
2695                 2700                 2705                            

ttc  aag cgt tgg ttc tgg  tca ata gta gag aag  atg agc atg aca        8205
Phe  Lys Arg Trp Phe Trp  Ser Ile Val Glu Lys  Met Ser Met Thr            
2710                 2715                 2720                            

gaa  cga caa gat ctt gtt  tac ttt tgg aca tca  agc cca tca ctg        8250
Glu  Arg Gln Asp Leu Val  Tyr Phe Trp Thr Ser  Ser Pro Ser Leu            
2725                 2730                 2735                            

cca  gcc agt gaa gaa gga  ttc cag cct atg ccc  tca atc aca ata        8295
Pro  Ala Ser Glu Glu Gly  Phe Gln Pro Met Pro  Ser Ile Thr Ile            
2740                 2745                 2750                            

aga  cca cca gat gac caa  cat ctt cct act gca  aat act tgc att        8340
Arg  Pro Pro Asp Asp Gln  His Leu Pro Thr Ala  Asn Thr Cys Ile            
2755                 2760                 2765                            

tct  cga ctt tac gtc cca  ctc tat tcc tct aaa  cag att ctc aaa        8385
Ser  Arg Leu Tyr Val Pro  Leu Tyr Ser Ser Lys  Gln Ile Leu Lys            
2770                 2775                 2780                            

cag  aaa ttg tta ctc gcc  att aag acc aag aat  ttt ggt ttt gtg        8430
Gln  Lys Leu Leu Leu Ala  Ile Lys Thr Lys Asn  Phe Gly Phe Val            
2785                 2790                 2795                            

tag agtataaaaa gtgtgtattg ctgtgtaata ttactagcaa attttgtaga            8483

tttttttcca tttgtctata aaagtttatg gaagttaatg ctgtcatacc cccctggtgg     8543

taccttaaag agataaaatg cagacattcc ttgctgagtt tatagcttaa aggcctaagg     8603

agcactagca acatttggct atattggttt gctagtcacc aacttctggg tctaacccca     8663

gccaaagatg acagcagaac aacataattt acactgtgat ttatcttttt gctgaggggg     8723

aaaaaatgta aatgttctga aaattcactg ctgcctttgt ggaaactgtt tcagcaaagg     8783

ttcttgtata gagggaatag ggaatttcaa aataaaaaat taagtatgtt ctgtgttttc     8843

attttaactt tttttatggt gtttaatttg tggttggctg caactgtgta tcatgtatat     8903

ggaacttgta aaaaagttct cgacattcag atcttaagag atgaaatcac ttttacctat     8963

aaaaaccact tttattgcgg tttgactgca ttgagctcta ggatattaaa tgatatcact     9023

aatattttgc atgtaatttg ctcatttgag tgagggcact ttttttgtac atatgatggg     9083

gccaatgcac aatactttta tcacaatcaa ctttttcttt gtatccctat ttcaatgagc     9143

agtcagtctc aagaggttac tgcacttcag ttctaactag acatttgtac taaggtattt     9203

cagttatgta aactcagcct gggcactttc tgataactgt aaaatgtttt ataagatcat     9263

gattattgaa gatacatttt ggaaaatttt aaatgttcgt gagcagctta actacttttg     9323

tatctagcct tttttaagta tcttgttaca tttacttttt taaataaaga aattacagaa     9383

gaaatgtcaa gaaaaaaaaa aaaaaaa                                         9410


<210>  562
<211>  2799
<212>  PRT
<213>  Homo sapiens

<400>  562

Met Thr Ser Ile His Phe Val Val His Pro Leu Pro Gly Thr Glu Asp 
1               5                   10                  15      


Gln Leu Asn Asp Arg Leu Arg Glu Val Ser Glu Lys Leu Asn Lys Tyr 
            20                  25                  30          


Asn Leu Asn Ser His Pro Pro Leu Asn Val Leu Glu Gln Ala Thr Ile 
        35                  40                  45              


Lys Gln Cys Val Val Gly Pro Asn His Ala Ala Phe Leu Leu Glu Asp 
    50                  55                  60                  


Gly Arg Val Cys Arg Ile Gly Phe Ser Val Gln Pro Asp Arg Leu Glu 
65                  70                  75                  80  


Leu Gly Lys Pro Asp Asn Asn Asp Gly Ser Lys Leu Asn Ser Asn Ser 
                85                  90                  95      


Gly Ala Gly Arg Thr Ser Arg Pro Gly Arg Thr Ser Asp Ser Pro Trp 
            100                 105                 110         


Phe Leu Ser Gly Ser Glu Thr Leu Gly Arg Leu Ala Gly Asn Thr Leu 
        115                 120                 125             


Gly Ser Arg Trp Ser Ser Gly Val Gly Gly Ser Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gly Arg Ser Ser Ala Gly Ala Arg Asp Ser Arg Arg Gln Thr Arg Val 
145                 150                 155                 160 


Ile Arg Thr Gly Arg Asp Arg Gly Ser Gly Leu Leu Gly Ser Gln Pro 
                165                 170                 175     


Gln Pro Val Ile Pro Ala Ser Val Ile Pro Glu Glu Leu Ile Ser Gln 
            180                 185                 190         


Ala Gln Val Val Leu Gln Gly Lys Ser Arg Ser Val Ile Ile Arg Glu 
        195                 200                 205             


Leu Gln Arg Thr Asn Leu Asp Val Asn Leu Ala Val Asn Asn Leu Leu 
    210                 215                 220                 


Ser Arg Asp Asp Glu Asp Gly Asp Asp Gly Asp Asp Thr Ala Ser Glu 
225                 230                 235                 240 


Ser Tyr Leu Pro Gly Glu Asp Leu Met Ser Leu Leu Asp Ala Asp Ile 
                245                 250                 255     


His Ser Ala His Pro Ser Val Ile Ile Asp Ala Asp Ala Met Phe Ser 
            260                 265                 270         


Glu Asp Ile Ser Tyr Phe Gly Tyr Pro Ser Phe Arg Arg Ser Ser Leu 
        275                 280                 285             


Ser Arg Leu Gly Ser Ser Arg Val Leu Leu Leu Pro Leu Glu Arg Asp 
    290                 295                 300                 


Ser Glu Leu Leu Arg Glu Arg Glu Ser Val Leu Arg Leu Arg Glu Arg 
305                 310                 315                 320 


Arg Trp Leu Asp Gly Ala Ser Phe Asp Asn Glu Arg Gly Ser Thr Ser 
                325                 330                 335     


Lys Glu Gly Glu Pro Asn Leu Asp Lys Lys Asn Thr Pro Val Gln Ser 
            340                 345                 350         


Pro Val Ser Leu Gly Glu Asp Leu Gln Trp Trp Pro Asp Lys Asp Gly 
        355                 360                 365             


Thr Lys Phe Ile Cys Ile Gly Ala Leu Tyr Ser Glu Leu Leu Ala Val 
    370                 375                 380                 


Ser Ser Lys Gly Glu Leu Tyr Gln Trp Lys Trp Ser Glu Ser Glu Pro 
385                 390                 395                 400 


Tyr Arg Asn Ala Gln Asn Pro Ser Leu His His Pro Arg Ala Thr Phe 
                405                 410                 415     


Leu Gly Leu Thr Asn Glu Lys Ile Val Leu Leu Ser Ala Asn Ser Ile 
            420                 425                 430         


Arg Ala Thr Val Ala Thr Glu Asn Asn Lys Val Ala Thr Trp Val Asp 
        435                 440                 445             


Glu Thr Leu Ser Ser Val Ala Ser Lys Leu Glu His Thr Ala Gln Thr 
    450                 455                 460                 


Tyr Ser Glu Leu Gln Gly Glu Arg Ile Val Ser Leu His Cys Cys Ala 
465                 470                 475                 480 


Leu Tyr Thr Cys Ala Gln Leu Glu Asn Ser Leu Tyr Trp Trp Gly Val 
                485                 490                 495     


Val Pro Phe Ser Gln Arg Lys Lys Met Leu Glu Lys Ala Arg Ala Lys 
            500                 505                 510         


Asn Lys Lys Pro Lys Ser Ser Ala Gly Ile Ser Ser Met Pro Asn Ile 
        515                 520                 525             


Thr Val Gly Thr Gln Val Cys Leu Arg Asn Asn Pro Leu Tyr His Ala 
    530                 535                 540                 


Gly Ala Val Ala Phe Ser Ile Ser Ala Gly Ile Pro Lys Val Gly Val 
545                 550                 555                 560 


Leu Met Glu Ser Val Trp Asn Met Asn Asp Ser Cys Arg Phe Gln Leu 
                565                 570                 575     


Arg Ser Pro Glu Ser Leu Lys Asn Met Glu Lys Ala Ser Lys Thr Thr 
            580                 585                 590         


Glu Ala Lys Pro Glu Ser Lys Gln Glu Pro Val Lys Thr Glu Met Gly 
        595                 600                 605             


Pro Pro Pro Ser Pro Ala Ser Thr Cys Ser Asp Ala Ser Ser Ile Ala 
    610                 615                 620                 


Ser Ser Ala Ser Met Pro Tyr Lys Arg Arg Arg Ser Thr Pro Ala Pro 
625                 630                 635                 640 


Lys Glu Glu Glu Lys Val Asn Glu Glu Gln Trp Ser Leu Arg Glu Val 
                645                 650                 655     


Val Phe Val Glu Asp Val Lys Asn Val Pro Val Gly Lys Val Leu Lys 
            660                 665                 670         


Val Asp Gly Ala Tyr Val Ala Val Lys Phe Pro Gly Thr Ser Ser Asn 
        675                 680                 685             


Thr Asn Cys Gln Asn Ser Ser Gly Pro Asp Ala Asp Pro Ser Ser Leu 
    690                 695                 700                 


Leu Gln Asp Cys Arg Leu Leu Arg Ile Asp Glu Leu Gln Val Val Lys 
705                 710                 715                 720 


Thr Gly Gly Thr Pro Lys Val Pro Asp Cys Phe Gln Arg Thr Pro Lys 
                725                 730                 735     


Lys Leu Cys Ile Pro Glu Lys Thr Glu Ile Leu Ala Val Asn Val Asp 
            740                 745                 750         


Ser Lys Gly Val His Ala Val Leu Lys Thr Gly Asn Trp Val Arg Tyr 
        755                 760                 765             


Cys Ile Phe Asp Leu Ala Thr Gly Lys Ala Glu Gln Glu Asn Asn Phe 
    770                 775                 780                 


Pro Thr Ser Ser Ile Ala Phe Leu Gly Gln Asn Glu Arg Asn Val Ala 
785                 790                 795                 800 


Ile Phe Thr Ala Gly Gln Glu Ser Pro Ile Ile Leu Arg Asp Gly Asn 
                805                 810                 815     


Gly Thr Ile Tyr Pro Met Ala Lys Asp Cys Met Gly Gly Ile Arg Asp 
            820                 825                 830         


Pro Asp Trp Leu Asp Leu Pro Pro Ile Ser Ser Leu Gly Met Gly Val 
        835                 840                 845             


His Ser Leu Ile Asn Leu Pro Ala Asn Ser Thr Ile Lys Lys Lys Ala 
    850                 855                 860                 


Ala Val Ile Ile Met Ala Val Glu Lys Gln Thr Leu Met Gln His Ile 
865                 870                 875                 880 


Leu Arg Cys Asp Tyr Glu Ala Cys Arg Gln Tyr Leu Met Asn Leu Glu 
                885                 890                 895     


Gln Ala Val Val Leu Glu Gln Asn Leu Gln Met Leu Gln Thr Phe Ile 
            900                 905                 910         


Ser His Arg Cys Asp Gly Asn Arg Asn Ile Leu His Ala Cys Val Ser 
        915                 920                 925             


Val Cys Phe Pro Thr Ser Asn Lys Glu Thr Lys Glu Glu Glu Glu Ala 
    930                 935                 940                 


Glu Arg Ser Glu Arg Asn Thr Phe Ala Glu Arg Leu Ser Ala Val Glu 
945                 950                 955                 960 


Ala Ile Ala Asn Ala Ile Ser Val Val Ser Ser Asn Gly Pro Gly Asn 
                965                 970                 975     


Arg Ala Gly Ser Ser Ser Ser Arg Ser Leu Arg Leu Arg Glu Met Met 
            980                 985                 990         


Arg Arg Ser Leu Arg Ala Ala Gly  Leu Gly Arg His Glu  Ala Gly Ala 
        995                 1000                 1005             


Ser Ser  Ser Asp His Gln Asp  Pro Val Ser Pro Pro  Ile Ala Pro 
    1010                 1015                 1020             


Pro Ser  Trp Val Pro Asp Pro  Pro Ala Met Asp Pro  Asp Gly Asp 
    1025                 1030                 1035             


Ile Asp  Phe Ile Leu Ala Pro  Ala Val Gly Ser Leu  Thr Thr Ala 
    1040                 1045                 1050             


Ala Thr  Gly Thr Gly Gln Gly  Pro Ser Thr Ser Thr  Ile Pro Gly 
    1055                 1060                 1065             


Pro Ser  Thr Glu Pro Ser Val  Val Glu Ser Lys Asp  Arg Lys Ala 
    1070                 1075                 1080             


Asn Ala  His Phe Ile Leu Lys  Leu Leu Cys Asp Ser  Val Val Leu 
    1085                 1090                 1095             


Gln Pro  Tyr Leu Arg Glu Leu  Leu Ser Ala Lys Asp  Ala Arg Gly 
    1100                 1105                 1110             


Met Thr  Pro Phe Met Ser Ala  Val Ser Gly Arg Ala  Tyr Pro Ala 
    1115                 1120                 1125             


Ala Ile  Thr Ile Leu Glu Thr  Ala Gln Lys Ile Ala  Lys Ala Glu 
    1130                 1135                 1140             


Ile Ser  Ser Ser Glu Lys Glu  Glu Asp Val Phe Met  Gly Met Val 
    1145                 1150                 1155             


Cys Pro  Ser Gly Thr Asn Pro  Asp Asp Ser Pro Leu  Tyr Val Leu 
    1160                 1165                 1170             


Cys Cys  Asn Asp Thr Cys Ser  Phe Thr Trp Thr Gly  Ala Glu His 
    1175                 1180                 1185             


Ile Asn  Gln Asp Ile Phe Glu  Cys Arg Thr Cys Gly  Leu Leu Glu 
    1190                 1195                 1200             


Ser Leu  Cys Cys Cys Thr Glu  Cys Ala Arg Val Cys  His Lys Gly 
    1205                 1210                 1215             


His Asp  Cys Lys Leu Lys Arg  Thr Ser Pro Thr Ala  Tyr Cys Asp 
    1220                 1225                 1230             


Cys Trp  Glu Lys Cys Lys Cys  Lys Thr Leu Ile Ala  Gly Gln Lys 
    1235                 1240                 1245             


Ser Ala  Arg Leu Asp Leu Leu  Tyr Arg Leu Leu Thr  Ala Thr Asn 
    1250                 1255                 1260             


Leu Val  Thr Leu Pro Asn Ser  Arg Gly Glu His Leu  Leu Leu Phe 
    1265                 1270                 1275             


Leu Val  Gln Thr Val Ala Arg  Gln Thr Val Glu His  Cys Gln Tyr 
    1280                 1285                 1290             


Arg Pro  Pro Arg Ile Arg Glu  Asp Arg Asn Arg Lys  Thr Ala Ser 
    1295                 1300                 1305             


Pro Glu  Asp Ser Asp Met Pro  Asp His Asp Leu Glu  Pro Pro Arg 
    1310                 1315                 1320             


Phe Ala  Gln Leu Ala Leu Glu  Arg Val Leu Gln Asp  Trp Asn Ala 
    1325                 1330                 1335             


Leu Lys  Ser Met Ile Met Phe  Gly Ser Gln Glu Asn  Lys Asp Pro 
    1340                 1345                 1350             


Leu Ser  Ala Ser Ser Arg Ile  Gly His Leu Leu Pro  Glu Glu Gln 
    1355                 1360                 1365             


Val Tyr  Leu Asn Gln Gln Ser  Gly Thr Ile Arg Leu  Asp Cys Phe 
    1370                 1375                 1380             


Thr His  Cys Leu Ile Val Lys  Cys Thr Ala Asp Ile  Leu Leu Leu 
    1385                 1390                 1395             


Asp Thr  Leu Leu Gly Thr Leu  Val Lys Glu Leu Gln  Asn Lys Tyr 
    1400                 1405                 1410             


Thr Pro  Gly Arg Arg Glu Glu  Ala Ile Ala Val Thr  Met Arg Phe 
    1415                 1420                 1425             


Leu Arg  Ser Val Ala Arg Val  Phe Val Ile Leu Ser  Val Glu Met 
    1430                 1435                 1440             


Ala Ser  Ser Lys Lys Lys Asn  Asn Phe Ile Pro Gln  Pro Ile Gly 
    1445                 1450                 1455             


Lys Cys  Lys Arg Val Phe Gln  Ala Leu Leu Pro Tyr  Ala Val Glu 
    1460                 1465                 1470             


Glu Leu  Cys Asn Val Ala Glu  Ser Leu Ile Val Pro  Val Arg Met 
    1475                 1480                 1485             


Gly Ile  Ala Arg Pro Thr Ala  Pro Phe Thr Leu Ala  Ser Thr Ser 
    1490                 1495                 1500             


Ile Asp  Ala Met Gln Gly Ser  Glu Glu Leu Phe Ser  Val Glu Pro 
    1505                 1510                 1515             


Leu Pro  Pro Arg Pro Ser Ser  Asp Gln Ser Ser Ser  Ser Ser Gln 
    1520                 1525                 1530             


Ser Gln  Ser Ser Tyr Ile Ile  Arg Asn Pro Gln Gln  Arg Arg Ile 
    1535                 1540                 1545             


Ser Gln  Ser Gln Pro Val Arg  Gly Arg Asp Glu Glu  Gln Asp Asp 
    1550                 1555                 1560             


Ile Val  Ser Ala Asp Val Glu  Glu Val Glu Val Val  Glu Gly Val 
    1565                 1570                 1575             


Ala Gly  Glu Glu Asp His His  Asp Glu Gln Glu Glu  His Gly Glu 
    1580                 1585                 1590             


Glu Asn  Ala Glu Ala Glu Gly  Gln His Asp Glu His  Asp Glu Asp 
    1595                 1600                 1605             


Gly Ser  Asp Met Glu Leu Asp  Leu Leu Ala Ala Ala  Glu Thr Glu 
    1610                 1615                 1620             


Ser Asp  Ser Glu Ser Asn His  Ser Asn Gln Asp Asn  Ala Ser Gly 
    1625                 1630                 1635             


Arg Arg  Ser Val Val Thr Ala  Ala Thr Ala Gly Ser  Glu Ala Gly 
    1640                 1645                 1650             


Ala Ser  Ser Val Pro Ala Phe  Phe Ser Glu Asp Asp  Ser Gln Ser 
    1655                 1660                 1665             


Asn Asp  Ser Ser Asp Ser Asp  Ser Ser Ser Ser Gln  Ser Asp Asp 
    1670                 1675                 1680             


Ile Glu  Gln Glu Thr Phe Met  Leu Asp Glu Pro Leu  Glu Arg Thr 
    1685                 1690                 1695             


Thr Asn  Ser Ser His Ala Asn  Gly Ala Ala Gln Ala  Pro Arg Ser 
    1700                 1705                 1710             


Met Gln  Trp Ala Val Arg Asn  Thr Gln His Gln Arg  Ala Ala Ser 
    1715                 1720                 1725             


Thr Ala  Pro Ser Ser Thr Ser  Thr Pro Ala Ala Ser  Ser Ala Gly 
    1730                 1735                 1740             


Leu Ile  Tyr Ile Asp Pro Ser  Asn Leu Arg Arg Ser  Gly Thr Ile 
    1745                 1750                 1755             


Ser Thr  Ser Ala Ala Ala Ala  Ala Ala Ala Leu Glu  Ala Ser Asn 
    1760                 1765                 1770             


Ala Ser  Ser Tyr Leu Thr Ser  Ala Ser Ser Leu Ala  Arg Ala Tyr 
    1775                 1780                 1785             


Ser Ile  Val Ile Arg Gln Ile  Ser Asp Leu Met Gly  Leu Ile Pro 
    1790                 1795                 1800             


Lys Tyr  Asn His Leu Val Tyr  Ser Gln Ile Pro Ala  Ala Val Lys 
    1805                 1810                 1815             


Leu Thr  Tyr Gln Asp Ala Val  Asn Leu Gln Asn Tyr  Val Glu Glu 
    1820                 1825                 1830             


Lys Leu  Ile Pro Thr Trp Asn  Trp Met Val Ser Ile  Met Asp Ser 
    1835                 1840                 1845             


Thr Glu  Ala Gln Leu Arg Tyr  Gly Ser Ala Leu Ala  Ser Ala Gly 
    1850                 1855                 1860             


Asp Pro  Gly His Pro Asn His  Pro Leu His Ala Ser  Gln Asn Ser 
    1865                 1870                 1875             


Ala Arg  Arg Glu Arg Met Thr  Ala Arg Glu Glu Ala  Ser Leu Arg 
    1880                 1885                 1890             


Thr Leu  Glu Gly Arg Arg Arg  Ala Thr Leu Leu Ser  Ala Arg Gln 
    1895                 1900                 1905             


Gly Met  Met Ser Ala Arg Gly  Asp Phe Leu Asn Tyr  Ala Leu Ser 
    1910                 1915                 1920             


Leu Met  Arg Ser His Asn Asp  Glu His Ser Asp Val  Leu Pro Val 
    1925                 1930                 1935             


Leu Asp  Val Cys Ser Leu Lys  His Val Ala Tyr Val  Phe Gln Ala 
    1940                 1945                 1950             


Leu Ile  Tyr Trp Ile Lys Ala  Met Asn Gln Gln Thr  Thr Leu Asp 
    1955                 1960                 1965             


Thr Pro  Gln Leu Glu Arg Lys  Arg Thr Arg Glu Leu  Leu Glu Leu 
    1970                 1975                 1980             


Gly Ile  Asp Asn Glu Asp Ser  Glu His Glu Asn Asp  Asp Asp Thr 
    1985                 1990                 1995             


Asn Gln  Ser Ala Thr Leu Asn  Asp Lys Asp Asp Asp  Ser Leu Pro 
    2000                 2005                 2010             


Ala Glu  Thr Gly Gln Asn His  Pro Phe Phe Arg Arg  Ser Asp Ser 
    2015                 2020                 2025             


Met Thr  Phe Leu Gly Cys Ile  Pro Pro Asn Pro Phe  Glu Val Pro 
    2030                 2035                 2040             


Leu Ala  Glu Ala Ile Pro Leu  Ala Asp Gln Pro His  Leu Leu Gln 
    2045                 2050                 2055             


Pro Asn  Ala Arg Lys Glu Asp  Leu Phe Gly Arg Pro  Ser Gln Gly 
    2060                 2065                 2070             


Leu Tyr  Ser Ser Ser Ala Ser  Ser Gly Lys Cys Leu  Met Glu Val 
    2075                 2080                 2085             


Thr Val  Asp Arg Asn Cys Leu  Glu Val Leu Pro Thr  Lys Met Ser 
    2090                 2095                 2100             


Tyr Ala  Ala Asn Leu Lys Asn  Val Met Asn Met Gln  Asn Arg Gln 
    2105                 2110                 2115             


Lys Lys  Glu Gly Glu Glu Gln  Pro Val Leu Pro Glu  Glu Thr Glu 
    2120                 2125                 2130             


Ser Ser  Lys Pro Gly Pro Ser  Ala His Asp Leu Ala  Ala Gln Leu 
    2135                 2140                 2145             


Lys Ser  Ser Leu Leu Ala Glu  Ile Gly Leu Thr Glu  Ser Glu Gly 
    2150                 2155                 2160             


Pro Pro  Leu Thr Ser Phe Arg  Pro Gln Cys Ser Phe  Met Gly Met 
    2165                 2170                 2175             


Val Ile  Ser His Asp Met Leu  Leu Gly Arg Trp Arg  Leu Ser Leu 
    2180                 2185                 2190             


Glu Leu  Phe Gly Arg Val Phe  Met Glu Asp Val Gly  Ala Glu Pro 
    2195                 2200                 2205             


Gly Ser  Ile Leu Thr Glu Leu  Gly Gly Phe Glu Val  Lys Glu Ser 
    2210                 2215                 2220             


Lys Phe  Arg Arg Glu Met Glu  Lys Leu Arg Asn Gln  Gln Ser Arg 
    2225                 2230                 2235             


Asp Leu  Ser Leu Glu Val Asp  Arg Asp Arg Asp Leu  Leu Ile Gln 
    2240                 2245                 2250             


Gln Thr  Met Arg Gln Leu Asn  Asn His Phe Gly Arg  Arg Cys Ala 
    2255                 2260                 2265             


Thr Thr  Pro Met Ala Val His  Arg Val Lys Val Thr  Phe Lys Asp 
    2270                 2275                 2280             


Glu Pro  Gly Glu Gly Ser Gly  Val Ala Arg Ser Phe  Tyr Thr Ala 
    2285                 2290                 2295             


Ile Ala  Gln Ala Phe Leu Ser  Asn Glu Lys Leu Pro  Asn Leu Glu 
    2300                 2305                 2310             


Cys Ile  Gln Asn Ala Asn Lys  Gly Thr His Thr Ser  Leu Met Gln 
    2315                 2320                 2325             


Arg Leu  Arg Asn Arg Gly Glu  Arg Asp Arg Glu Arg  Glu Arg Glu 
    2330                 2335                 2340             


Arg Glu  Met Arg Arg Ser Ser  Gly Leu Arg Ala Gly  Ser Arg Arg 
    2345                 2350                 2355             


Asp Arg  Asp Arg Asp Phe Arg  Arg Gln Leu Ser Ile  Asp Thr Arg 
    2360                 2365                 2370             


Pro Phe  Arg Pro Ala Ser Glu  Gly Asn Pro Ser Asp  Asp Pro Glu 
    2375                 2380                 2385             


Pro Leu  Pro Ala His Arg Gln  Ala Leu Gly Glu Arg  Leu Tyr Pro 
    2390                 2395                 2400             


Arg Val  Gln Ala Met Gln Pro  Ala Phe Ala Ser Lys  Ile Thr Gly 
    2405                 2410                 2415             


Met Leu  Leu Glu Leu Ser Pro  Ala Gln Leu Leu Leu  Leu Leu Ala 
    2420                 2425                 2430             


Ser Glu  Asp Ser Leu Arg Ala  Arg Val Asp Glu Ala  Met Glu Leu 
    2435                 2440                 2445             


Ile Ile  Ala His Gly Arg Glu  Asn Gly Ala Asp Ser  Ile Leu Asp 
    2450                 2455                 2460             


Leu Gly  Leu Val Asp Ser Ser  Glu Lys Val Gln Gln  Glu Asn Arg 
    2465                 2470                 2475             


Lys Arg  His Gly Ser Ser Arg  Ser Val Val Asp Met  Asp Leu Asp 
    2480                 2485                 2490             


Asp Thr  Asp Asp Gly Asp Asp  Asn Ala Pro Leu Phe  Tyr Gln Pro 
    2495                 2500                 2505             


Gly Lys  Arg Gly Phe Tyr Thr  Pro Arg Pro Gly Lys  Asn Thr Glu 
    2510                 2515                 2520             


Ala Arg  Leu Asn Cys Phe Arg  Asn Ile Gly Arg Ile  Leu Gly Leu 
    2525                 2530                 2535             


Cys Leu  Leu Gln Asn Glu Leu  Cys Pro Ile Thr Leu  Asn Arg His 
    2540                 2545                 2550             


Val Ile  Lys Val Leu Leu Gly  Arg Lys Val Asn Trp  His Asp Phe 
    2555                 2560                 2565             


Ala Phe  Phe Asp Pro Val Met  Tyr Glu Ser Leu Arg  Gln Leu Ile 
    2570                 2575                 2580             


Leu Ala  Ser Gln Ser Ser Asp  Ala Asp Ala Val Phe  Ser Ala Met 
    2585                 2590                 2595             


Asp Leu  Ala Phe Ala Ile Asp  Leu Cys Lys Glu Glu  Gly Gly Gly 
    2600                 2605                 2610             


Gln Val  Glu Leu Ile Pro Asn  Gly Val Asn Ile Pro  Val Thr Pro 
    2615                 2620                 2625             


Gln Asn  Val Tyr Glu Tyr Val  Arg Lys Tyr Ala Glu  His Arg Met 
    2630                 2635                 2640             


Leu Val  Val Ala Glu Gln Pro  Leu His Ala Met Arg  Lys Gly Leu 
    2645                 2650                 2655             


Leu Asp  Val Leu Pro Lys Asn  Ser Leu Glu Asp Leu  Thr Ala Glu 
    2660                 2665                 2670             


Asp Phe  Arg Leu Leu Val Asn  Gly Cys Gly Glu Val  Asn Val Gln 
    2675                 2680                 2685             


Met Leu  Ile Ser Phe Thr Ser  Phe Asn Asp Glu Ser  Gly Glu Asn 
    2690                 2695                 2700             


Ala Glu  Lys Leu Leu Gln Phe  Lys Arg Trp Phe Trp  Ser Ile Val 
    2705                 2710                 2715             


Glu Lys  Met Ser Met Thr Glu  Arg Gln Asp Leu Val  Tyr Phe Trp 
    2720                 2725                 2730             


Thr Ser  Ser Pro Ser Leu Pro  Ala Ser Glu Glu Gly  Phe Gln Pro 
    2735                 2740                 2745             


Met Pro  Ser Ile Thr Ile Arg  Pro Pro Asp Asp Gln  His Leu Pro 
    2750                 2755                 2760             


Thr Ala  Asn Thr Cys Ile Ser  Arg Leu Tyr Val Pro  Leu Tyr Ser 
    2765                 2770                 2775             


Ser Lys  Gln Ile Leu Lys Gln  Lys Leu Leu Leu Ala  Ile Lys Thr 
    2780                 2785                 2790             


Lys Asn  Phe Gly Phe Val 
    2795                 


<210>  563
<211>  3231
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (77)..(3112)

<400>  563
cccggccggg tctgggggcg gggcgtttgc ccggcctttc cagggccggg gaaccccagg       60

aggaagctgc tgagcc atg ggc gcc tac gcg cgg gct tcg ggg gtc tgc gct      112
                  Met Gly Ala Tyr Ala Arg Ala Ser Gly Val Cys Ala         
                  1               5                   10                  

cgc ggc tgc ctg gac tca gca ggc ccc tgg acc atg tcc cgc gcc ctg        160
Arg Gly Cys Leu Asp Ser Ala Gly Pro Trp Thr Met Ser Arg Ala Leu           
        15                  20                  25                        

cgg cca ccg ctc ccg cct ctc tgc ttt ttc ctt ttg ttg ctg gcg gct        208
Arg Pro Pro Leu Pro Pro Leu Cys Phe Phe Leu Leu Leu Leu Ala Ala           
    30                  35                  40                            

gcc ggt gct cgg gcc ggg gga tac gag aca tgc ccc aca gtg cag ccg        256
Ala Gly Ala Arg Ala Gly Gly Tyr Glu Thr Cys Pro Thr Val Gln Pro           
45                  50                  55                  60            

aac atg ctg aac gtg cac ctg ctg cct cac aca cat gat gac gtg ggc        304
Asn Met Leu Asn Val His Leu Leu Pro His Thr His Asp Asp Val Gly           
                65                  70                  75                

tgg ctc aaa acc gtg gac cag tac ttt tat gga atc aag aat gac atc        352
Trp Leu Lys Thr Val Asp Gln Tyr Phe Tyr Gly Ile Lys Asn Asp Ile           
            80                  85                  90                    

cag cac gcc ggt gtg cag tac atc ctg gac tcg gtc atc tct gcc ttg        400
Gln His Ala Gly Val Gln Tyr Ile Leu Asp Ser Val Ile Ser Ala Leu           
        95                  100                 105                       

ctg gca gat ccc acc cgt cgc ttc att tac gtg gag att gcc ttc ttc        448
Leu Ala Asp Pro Thr Arg Arg Phe Ile Tyr Val Glu Ile Ala Phe Phe           
    110                 115                 120                           

tcc cgt tgg tgg cac cag cag aca aat gcc aca cag gaa gtc gtg cga        496
Ser Arg Trp Trp His Gln Gln Thr Asn Ala Thr Gln Glu Val Val Arg           
125                 130                 135                 140           

gac ctt gtg cgc cag ggg cgc ctg gag ttc gcc aat ggt ggc tgg gtg        544
Asp Leu Val Arg Gln Gly Arg Leu Glu Phe Ala Asn Gly Gly Trp Val           
                145                 150                 155               

atg aac gat gag gca gcc acc cac tac ggt gcc atc gtg gac cag atg        592
Met Asn Asp Glu Ala Ala Thr His Tyr Gly Ala Ile Val Asp Gln Met           
            160                 165                 170                   

aca ctt ggg ctg cgc ttt ctg gag gac aca ttt ggc aat gat ggg cga        640
Thr Leu Gly Leu Arg Phe Leu Glu Asp Thr Phe Gly Asn Asp Gly Arg           
        175                 180                 185                       

ccc cgt gtg gcc tgg cac att gac ccc ttc ggc cac tct cgg gag cag        688
Pro Arg Val Ala Trp His Ile Asp Pro Phe Gly His Ser Arg Glu Gln           
    190                 195                 200                           

gcc tcg ctg ttt gcg cag atg ggc ttc gac ggc ttc ttc ttt ggg cgc        736
Ala Ser Leu Phe Ala Gln Met Gly Phe Asp Gly Phe Phe Phe Gly Arg           
205                 210                 215                 220           

ctt gat tat caa gat aag tgg gta cgg atg cag aag ctg gag atg gag        784
Leu Asp Tyr Gln Asp Lys Trp Val Arg Met Gln Lys Leu Glu Met Glu           
                225                 230                 235               

cag gtg tgg cgg gcc agc acc agc ctg aag ccc ccg acc gcg gac ctc        832
Gln Val Trp Arg Ala Ser Thr Ser Leu Lys Pro Pro Thr Ala Asp Leu           
            240                 245                 250                   

ttc act ggt gtg ctt ccc aat ggt tac aac ccg cca agg aat ctg tgc        880
Phe Thr Gly Val Leu Pro Asn Gly Tyr Asn Pro Pro Arg Asn Leu Cys           
        255                 260                 265                       

tgg gat gtg ctg tgt gtc gat cag ccg ctg gtg gag gac cct cgc agc        928
Trp Asp Val Leu Cys Val Asp Gln Pro Leu Val Glu Asp Pro Arg Ser           
    270                 275                 280                           

ccc gag tac aac gcc aag gag ctg gtc gat tac ttc cta aat gtg gcc        976
Pro Glu Tyr Asn Ala Lys Glu Leu Val Asp Tyr Phe Leu Asn Val Ala           
285                 290                 295                 300           

act gcc cag ggc cgg tat tac cgc acc aac cac act gtg atg acc atg       1024
Thr Ala Gln Gly Arg Tyr Tyr Arg Thr Asn His Thr Val Met Thr Met           
                305                 310                 315               

ggc tcg gac ttc caa tat gag aat gcc aac atg tgg ttc aag aac ctt       1072
Gly Ser Asp Phe Gln Tyr Glu Asn Ala Asn Met Trp Phe Lys Asn Leu           
            320                 325                 330                   

gac aag ctc atc cgg ctg gta aat gcg cag cag gca aaa gga agc agt       1120
Asp Lys Leu Ile Arg Leu Val Asn Ala Gln Gln Ala Lys Gly Ser Ser           
        335                 340                 345                       

gtc cat gtt ctc tac tcc acc ccc gct tgt tac ctc tgg gag ctg aac       1168
Val His Val Leu Tyr Ser Thr Pro Ala Cys Tyr Leu Trp Glu Leu Asn           
    350                 355                 360                           

aag gcc aac ctc acc tgg tca gtg aaa cat gac gac ttc ttc cct tac       1216
Lys Ala Asn Leu Thr Trp Ser Val Lys His Asp Asp Phe Phe Pro Tyr           
365                 370                 375                 380           

gcg gat ggc ccc cac cag ttc tgg acc ggt tac ttt tcc agt cgg ccg       1264
Ala Asp Gly Pro His Gln Phe Trp Thr Gly Tyr Phe Ser Ser Arg Pro           
                385                 390                 395               

gcc ctc aaa cgc tac gag cgc ctc agc tac aac ttc ctg cag gtg tgc       1312
Ala Leu Lys Arg Tyr Glu Arg Leu Ser Tyr Asn Phe Leu Gln Val Cys           
            400                 405                 410                   

aac cag ctg gag gcg ctg gtg ggc ctg gcg gcc aac gtg gga ccc tat       1360
Asn Gln Leu Glu Ala Leu Val Gly Leu Ala Ala Asn Val Gly Pro Tyr           
        415                 420                 425                       

ggc tcc gga gac agt gca ccc ctc aat gag gcg atg gct gtg ctc cag       1408
Gly Ser Gly Asp Ser Ala Pro Leu Asn Glu Ala Met Ala Val Leu Gln           
    430                 435                 440                           

cat cac gac gcc gtc agc ggc acc tcc cgc cag cac gtg gcc aac gac       1456
His His Asp Ala Val Ser Gly Thr Ser Arg Gln His Val Ala Asn Asp           
445                 450                 455                 460           

tac gcg cgc cag ctt gcg gca ggc tgg ggg cct tgc gag gtt ctt ctg       1504
Tyr Ala Arg Gln Leu Ala Ala Gly Trp Gly Pro Cys Glu Val Leu Leu           
                465                 470                 475               

agc aac gcg ctg gcg cgg ctc aga ggc ttc aaa gat cac ttc acc ttt       1552
Ser Asn Ala Leu Ala Arg Leu Arg Gly Phe Lys Asp His Phe Thr Phe           
            480                 485                 490                   

tgc caa cag cta aac atc agc atc tgc ccg ctc agc cag acg gcg gcg       1600
Cys Gln Gln Leu Asn Ile Ser Ile Cys Pro Leu Ser Gln Thr Ala Ala           
        495                 500                 505                       

cgc ttc cag gtc atc gtt tat aat ccc ctg ggg cgg aag gtg aat tgg       1648
Arg Phe Gln Val Ile Val Tyr Asn Pro Leu Gly Arg Lys Val Asn Trp           
    510                 515                 520                           

atg gta cgg ctg ccg gtc agc gaa ggc gtt ttc gtt gtg aag gac ccc       1696
Met Val Arg Leu Pro Val Ser Glu Gly Val Phe Val Val Lys Asp Pro           
525                 530                 535                 540           

aat ggc agg aca gtg ccc agc gat gtg gta ata ttt ccc agc tca gac       1744
Asn Gly Arg Thr Val Pro Ser Asp Val Val Ile Phe Pro Ser Ser Asp           
                545                 550                 555               

agc cag gcg cac cct ccg gag ctg ctg ttc tca gcc tca ctg ccc gcc       1792
Ser Gln Ala His Pro Pro Glu Leu Leu Phe Ser Ala Ser Leu Pro Ala           
            560                 565                 570                   

ctg ggc ttc agc acc tat tca gta gcc cag gtg cct cgc tgg aag ccc       1840
Leu Gly Phe Ser Thr Tyr Ser Val Ala Gln Val Pro Arg Trp Lys Pro           
        575                 580                 585                       

cag gcc cgc gca cca cag ccc atc ccc aga aga tcc tgg tcc cct gct       1888
Gln Ala Arg Ala Pro Gln Pro Ile Pro Arg Arg Ser Trp Ser Pro Ala           
    590                 595                 600                           

tta acc atc gaa aat gag cac atc cgg gca acg ttt gat cct gac aca       1936
Leu Thr Ile Glu Asn Glu His Ile Arg Ala Thr Phe Asp Pro Asp Thr           
605                 610                 615                 620           

ggg ctg ttg atg gag att atg aac atg aat cag caa ctc ctg ctg cct       1984
Gly Leu Leu Met Glu Ile Met Asn Met Asn Gln Gln Leu Leu Leu Pro           
                625                 630                 635               

gtt cgc cag acc ttc ttc tgg tac aac gcc agt ata ggt gac aac gaa       2032
Val Arg Gln Thr Phe Phe Trp Tyr Asn Ala Ser Ile Gly Asp Asn Glu           
            640                 645                 650                   

agt gac cag gcc tca ggt gcc tac atc ttc aga ccc aac caa cag aaa       2080
Ser Asp Gln Ala Ser Gly Ala Tyr Ile Phe Arg Pro Asn Gln Gln Lys           
        655                 660                 665                       

ccg ctg cct gtg agc cgc tgg gct cag atc cac ctg gtg aag aca ccc       2128
Pro Leu Pro Val Ser Arg Trp Ala Gln Ile His Leu Val Lys Thr Pro           
    670                 675                 680                           

ttg gtg cag gag gtg cac cag aac ttc tca gct tgg tgt tcc cag gtg       2176
Leu Val Gln Glu Val His Gln Asn Phe Ser Ala Trp Cys Ser Gln Val           
685                 690                 695                 700           

gtt cgc ctg tac cca gga cag cgg cac ctg gag cta gag tgg tcg gtg       2224
Val Arg Leu Tyr Pro Gly Gln Arg His Leu Glu Leu Glu Trp Ser Val           
                705                 710                 715               

ggg ccg ata cct gtg ggc gac acc tgg ggg aag gag gtc atc agc cgt       2272
Gly Pro Ile Pro Val Gly Asp Thr Trp Gly Lys Glu Val Ile Ser Arg           
            720                 725                 730                   

ttt gac aca ccg ctg gag aca aag gga cgc ttc tac aca gac agc aat       2320
Phe Asp Thr Pro Leu Glu Thr Lys Gly Arg Phe Tyr Thr Asp Ser Asn           
        735                 740                 745                       

ggc cgg gag atc ctg gag agg agg cgg gat tat cga ccc acc tgg aaa       2368
Gly Arg Glu Ile Leu Glu Arg Arg Arg Asp Tyr Arg Pro Thr Trp Lys           
    750                 755                 760                           

ctg aac cag acg gag ccc gtg gca gga aac tac tat cca gtc aac acc       2416
Leu Asn Gln Thr Glu Pro Val Ala Gly Asn Tyr Tyr Pro Val Asn Thr           
765                 770                 775                 780           

cgg att tac atc acg gat gga aac atg cag ctg act gtg ctg act gac       2464
Arg Ile Tyr Ile Thr Asp Gly Asn Met Gln Leu Thr Val Leu Thr Asp           
                785                 790                 795               

cgc tcc cag ggg ggc agc agc ctg aga gat ggc tcg ctg gag ctc atg       2512
Arg Ser Gln Gly Gly Ser Ser Leu Arg Asp Gly Ser Leu Glu Leu Met           
            800                 805                 810                   

gtg cac cga agg ctg ctg aag gac gat gga cgc gga gta tcg gag cca       2560
Val His Arg Arg Leu Leu Lys Asp Asp Gly Arg Gly Val Ser Glu Pro           
        815                 820                 825                       

cta atg gag aac ggg tcg ggg gcg tgg gtg cga ggg cgc cac ctg gtg       2608
Leu Met Glu Asn Gly Ser Gly Ala Trp Val Arg Gly Arg His Leu Val           
    830                 835                 840                           

ctg ctg gac aca gcc cag gct gca gcc gcc gga cac cgg ctc ctg gcg       2656
Leu Leu Asp Thr Ala Gln Ala Ala Ala Ala Gly His Arg Leu Leu Ala           
845                 850                 855                 860           

gag cag gag gtc ctg gcc cct cag gtg gtg ctg gcc ccg ggt ggc ggc       2704
Glu Gln Glu Val Leu Ala Pro Gln Val Val Leu Ala Pro Gly Gly Gly           
                865                 870                 875               

gcc gcc tac aat ctc ggg gct cct ccg cgc acg cag ttc tca ggg ctg       2752
Ala Ala Tyr Asn Leu Gly Ala Pro Pro Arg Thr Gln Phe Ser Gly Leu           
            880                 885                 890                   

cgc agg gac ctg ccg ccc tcg gtg cac ctg ctc acg ctg gcc agc tgg       2800
Arg Arg Asp Leu Pro Pro Ser Val His Leu Leu Thr Leu Ala Ser Trp           
        895                 900                 905                       

ggc ccc gaa atg gtg ctg ctg cgc ttg gag cac cag ttt gcc gta gga       2848
Gly Pro Glu Met Val Leu Leu Arg Leu Glu His Gln Phe Ala Val Gly           
    910                 915                 920                           

gag gat tcc gga cgt aac ctg agc gcc ccc gtt acc ttg aac ttg agg       2896
Glu Asp Ser Gly Arg Asn Leu Ser Ala Pro Val Thr Leu Asn Leu Arg           
925                 930                 935                 940           

gac ctg ttc tcc acc ttc acc atc acc cgc ctg cag gag acc acg ctg       2944
Asp Leu Phe Ser Thr Phe Thr Ile Thr Arg Leu Gln Glu Thr Thr Leu           
                945                 950                 955               

gtg gcc aac cag ctc cgc gag gca gcc tcc agg ctc aag tgg aca aca       2992
Val Ala Asn Gln Leu Arg Glu Ala Ala Ser Arg Leu Lys Trp Thr Thr           
            960                 965                 970                   

aac aca ggc ccc aca ccc cac caa act ccg tac cag ctg gac ccg gcc       3040
Asn Thr Gly Pro Thr Pro His Gln Thr Pro Tyr Gln Leu Asp Pro Ala           
        975                 980                 985                       

aac atc acg ctg gaa ccc atg gaa atc cgc act ttc  ctg gcc tca gtt      3088
Asn Ile Thr Leu Glu Pro Met Glu Ile Arg Thr Phe  Leu Ala Ser Val          
    990                 995                 1000                          

caa  tgg aag gag gtg gat  ggt tag gtctgctggg atgggccctc               3132
Gln  Trp Lys Glu Val Asp  Gly                                             
1005                 1010                                                 

caagcccaag cctcctgctc cgggggcaga ccagactctg actctcctct tggggctgct     3192

gccattaaaa cgctactact aagactcagg tcaaaaaaa                            3231


<210>  564
<211>  1011
<212>  PRT
<213>  Homo sapiens

<400>  564

Met Gly Ala Tyr Ala Arg Ala Ser Gly Val Cys Ala Arg Gly Cys Leu 
1               5                   10                  15      


Asp Ser Ala Gly Pro Trp Thr Met Ser Arg Ala Leu Arg Pro Pro Leu 
            20                  25                  30          


Pro Pro Leu Cys Phe Phe Leu Leu Leu Leu Ala Ala Ala Gly Ala Arg 
        35                  40                  45              


Ala Gly Gly Tyr Glu Thr Cys Pro Thr Val Gln Pro Asn Met Leu Asn 
    50                  55                  60                  


Val His Leu Leu Pro His Thr His Asp Asp Val Gly Trp Leu Lys Thr 
65                  70                  75                  80  


Val Asp Gln Tyr Phe Tyr Gly Ile Lys Asn Asp Ile Gln His Ala Gly 
                85                  90                  95      


Val Gln Tyr Ile Leu Asp Ser Val Ile Ser Ala Leu Leu Ala Asp Pro 
            100                 105                 110         


Thr Arg Arg Phe Ile Tyr Val Glu Ile Ala Phe Phe Ser Arg Trp Trp 
        115                 120                 125             


His Gln Gln Thr Asn Ala Thr Gln Glu Val Val Arg Asp Leu Val Arg 
    130                 135                 140                 


Gln Gly Arg Leu Glu Phe Ala Asn Gly Gly Trp Val Met Asn Asp Glu 
145                 150                 155                 160 


Ala Ala Thr His Tyr Gly Ala Ile Val Asp Gln Met Thr Leu Gly Leu 
                165                 170                 175     


Arg Phe Leu Glu Asp Thr Phe Gly Asn Asp Gly Arg Pro Arg Val Ala 
            180                 185                 190         


Trp His Ile Asp Pro Phe Gly His Ser Arg Glu Gln Ala Ser Leu Phe 
        195                 200                 205             


Ala Gln Met Gly Phe Asp Gly Phe Phe Phe Gly Arg Leu Asp Tyr Gln 
    210                 215                 220                 


Asp Lys Trp Val Arg Met Gln Lys Leu Glu Met Glu Gln Val Trp Arg 
225                 230                 235                 240 


Ala Ser Thr Ser Leu Lys Pro Pro Thr Ala Asp Leu Phe Thr Gly Val 
                245                 250                 255     


Leu Pro Asn Gly Tyr Asn Pro Pro Arg Asn Leu Cys Trp Asp Val Leu 
            260                 265                 270         


Cys Val Asp Gln Pro Leu Val Glu Asp Pro Arg Ser Pro Glu Tyr Asn 
        275                 280                 285             


Ala Lys Glu Leu Val Asp Tyr Phe Leu Asn Val Ala Thr Ala Gln Gly 
    290                 295                 300                 


Arg Tyr Tyr Arg Thr Asn His Thr Val Met Thr Met Gly Ser Asp Phe 
305                 310                 315                 320 


Gln Tyr Glu Asn Ala Asn Met Trp Phe Lys Asn Leu Asp Lys Leu Ile 
                325                 330                 335     


Arg Leu Val Asn Ala Gln Gln Ala Lys Gly Ser Ser Val His Val Leu 
            340                 345                 350         


Tyr Ser Thr Pro Ala Cys Tyr Leu Trp Glu Leu Asn Lys Ala Asn Leu 
        355                 360                 365             


Thr Trp Ser Val Lys His Asp Asp Phe Phe Pro Tyr Ala Asp Gly Pro 
    370                 375                 380                 


His Gln Phe Trp Thr Gly Tyr Phe Ser Ser Arg Pro Ala Leu Lys Arg 
385                 390                 395                 400 


Tyr Glu Arg Leu Ser Tyr Asn Phe Leu Gln Val Cys Asn Gln Leu Glu 
                405                 410                 415     


Ala Leu Val Gly Leu Ala Ala Asn Val Gly Pro Tyr Gly Ser Gly Asp 
            420                 425                 430         


Ser Ala Pro Leu Asn Glu Ala Met Ala Val Leu Gln His His Asp Ala 
        435                 440                 445             


Val Ser Gly Thr Ser Arg Gln His Val Ala Asn Asp Tyr Ala Arg Gln 
    450                 455                 460                 


Leu Ala Ala Gly Trp Gly Pro Cys Glu Val Leu Leu Ser Asn Ala Leu 
465                 470                 475                 480 


Ala Arg Leu Arg Gly Phe Lys Asp His Phe Thr Phe Cys Gln Gln Leu 
                485                 490                 495     


Asn Ile Ser Ile Cys Pro Leu Ser Gln Thr Ala Ala Arg Phe Gln Val 
            500                 505                 510         


Ile Val Tyr Asn Pro Leu Gly Arg Lys Val Asn Trp Met Val Arg Leu 
        515                 520                 525             


Pro Val Ser Glu Gly Val Phe Val Val Lys Asp Pro Asn Gly Arg Thr 
    530                 535                 540                 


Val Pro Ser Asp Val Val Ile Phe Pro Ser Ser Asp Ser Gln Ala His 
545                 550                 555                 560 


Pro Pro Glu Leu Leu Phe Ser Ala Ser Leu Pro Ala Leu Gly Phe Ser 
                565                 570                 575     


Thr Tyr Ser Val Ala Gln Val Pro Arg Trp Lys Pro Gln Ala Arg Ala 
            580                 585                 590         


Pro Gln Pro Ile Pro Arg Arg Ser Trp Ser Pro Ala Leu Thr Ile Glu 
        595                 600                 605             


Asn Glu His Ile Arg Ala Thr Phe Asp Pro Asp Thr Gly Leu Leu Met 
    610                 615                 620                 


Glu Ile Met Asn Met Asn Gln Gln Leu Leu Leu Pro Val Arg Gln Thr 
625                 630                 635                 640 


Phe Phe Trp Tyr Asn Ala Ser Ile Gly Asp Asn Glu Ser Asp Gln Ala 
                645                 650                 655     


Ser Gly Ala Tyr Ile Phe Arg Pro Asn Gln Gln Lys Pro Leu Pro Val 
            660                 665                 670         


Ser Arg Trp Ala Gln Ile His Leu Val Lys Thr Pro Leu Val Gln Glu 
        675                 680                 685             


Val His Gln Asn Phe Ser Ala Trp Cys Ser Gln Val Val Arg Leu Tyr 
    690                 695                 700                 


Pro Gly Gln Arg His Leu Glu Leu Glu Trp Ser Val Gly Pro Ile Pro 
705                 710                 715                 720 


Val Gly Asp Thr Trp Gly Lys Glu Val Ile Ser Arg Phe Asp Thr Pro 
                725                 730                 735     


Leu Glu Thr Lys Gly Arg Phe Tyr Thr Asp Ser Asn Gly Arg Glu Ile 
            740                 745                 750         


Leu Glu Arg Arg Arg Asp Tyr Arg Pro Thr Trp Lys Leu Asn Gln Thr 
        755                 760                 765             


Glu Pro Val Ala Gly Asn Tyr Tyr Pro Val Asn Thr Arg Ile Tyr Ile 
    770                 775                 780                 


Thr Asp Gly Asn Met Gln Leu Thr Val Leu Thr Asp Arg Ser Gln Gly 
785                 790                 795                 800 


Gly Ser Ser Leu Arg Asp Gly Ser Leu Glu Leu Met Val His Arg Arg 
                805                 810                 815     


Leu Leu Lys Asp Asp Gly Arg Gly Val Ser Glu Pro Leu Met Glu Asn 
            820                 825                 830         


Gly Ser Gly Ala Trp Val Arg Gly Arg His Leu Val Leu Leu Asp Thr 
        835                 840                 845             


Ala Gln Ala Ala Ala Ala Gly His Arg Leu Leu Ala Glu Gln Glu Val 
    850                 855                 860                 


Leu Ala Pro Gln Val Val Leu Ala Pro Gly Gly Gly Ala Ala Tyr Asn 
865                 870                 875                 880 


Leu Gly Ala Pro Pro Arg Thr Gln Phe Ser Gly Leu Arg Arg Asp Leu 
                885                 890                 895     


Pro Pro Ser Val His Leu Leu Thr Leu Ala Ser Trp Gly Pro Glu Met 
            900                 905                 910         


Val Leu Leu Arg Leu Glu His Gln Phe Ala Val Gly Glu Asp Ser Gly 
        915                 920                 925             


Arg Asn Leu Ser Ala Pro Val Thr Leu Asn Leu Arg Asp Leu Phe Ser 
    930                 935                 940                 


Thr Phe Thr Ile Thr Arg Leu Gln Glu Thr Thr Leu Val Ala Asn Gln 
945                 950                 955                 960 


Leu Arg Glu Ala Ala Ser Arg Leu Lys Trp Thr Thr Asn Thr Gly Pro 
                965                 970                 975     


Thr Pro His Gln Thr Pro Tyr Gln Leu Asp Pro Ala Asn Ile Thr Leu 
            980                 985                 990         


Glu Pro Met Glu Ile Arg Thr Phe  Leu Ala Ser Val Gln  Trp Lys Glu 
        995                 1000                 1005             


Val Asp  Gly 
    1010     


<210>  565
<211>  1519
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (514)..(1125)

<400>  565
ggcggttacc tcatcgccgc ctccgggagg ccccgctcgc tcgcgccggc ggctggggcg       60

gcgactccag gcgcggaagc gagagaagga tagaggcaca gaggctccgg gaggcagcgc      120

tgccccccgc gccccgcacc gctgcgggac ccgcgccgcg agaggggcgg acttcggcgc      180

ctcgcgcgtc cgccggcgcc tgggttggcg ctgcggggcg gaggcggtgt ctgagcgccg      240

ctccggctct gctctctctc gagcttcggc acccgcccga gccgctcgcg cgcccgccac      300

ctgtctgccc actcggctgt ctgtctgccc tcccgccgcc agctcctgcc tcgggcctgc      360

cctctccggt ctcggtgctc cgaggggcga cgagaagcgc gacggggccg tggcgcaccg      420

ggcagggcgc gcggggcgca cggcctgggg gcgcacggtg cggcgccggc ccatgaggct      480

ttccagcgcg gggagcggca gcgccggccg gcc atg ggg ggt agc ctg cgg gtg       534
                                     Met Gly Gly Ser Leu Arg Val          
                                     1               5                    

gcc gtt cta ggc gcc ccg ggc gtg ggc aag acg gcc atc atc cgc cag        582
Ala Val Leu Gly Ala Pro Gly Val Gly Lys Thr Ala Ile Ile Arg Gln           
        10                  15                  20                        

ttc ctg ttc ggt gac tac ccc gag cgc cac cgg ccc acg gac ggg ccg        630
Phe Leu Phe Gly Asp Tyr Pro Glu Arg His Arg Pro Thr Asp Gly Pro           
    25                  30                  35                            

cgc ctc tac cga ccc gcg gtg ctg ctc gac ggc gcc gtc tac gac ttg        678
Arg Leu Tyr Arg Pro Ala Val Leu Leu Asp Gly Ala Val Tyr Asp Leu           
40                  45                  50                  55            

agc atc cgc gac ggc gac gtc gct ggc ccc ggc tcg agc ccc ggg ggt        726
Ser Ile Arg Asp Gly Asp Val Ala Gly Pro Gly Ser Ser Pro Gly Gly           
                60                  65                  70                

ccg gag gag tgg cca gac gct aag gac tgg agc ttg cag gac acg gac        774
Pro Glu Glu Trp Pro Asp Ala Lys Asp Trp Ser Leu Gln Asp Thr Asp           
            75                  80                  85                    

gcc ttc gtg ctc gtc tac gac atc tgc agc ccg gac agt ttc gac tac        822
Ala Phe Val Leu Val Tyr Asp Ile Cys Ser Pro Asp Ser Phe Asp Tyr           
        90                  95                  100                       

gtg aag gcc ctg cgg cag cgc atc gcg gag acc agg ccg gcg ggc gcg        870
Val Lys Ala Leu Arg Gln Arg Ile Ala Glu Thr Arg Pro Ala Gly Ala           
    105                 110                 115                           

ccc gaa gcg ccc atc ctc gtg gta ggc aac aag cgg gac agg cag cgg        918
Pro Glu Ala Pro Ile Leu Val Val Gly Asn Lys Arg Asp Arg Gln Arg           
120                 125                 130                 135           

ctg cgc ttc gga ccg cgg cgc gcg ctg gcc gcc cta gtg cgc agg ggc        966
Leu Arg Phe Gly Pro Arg Arg Ala Leu Ala Ala Leu Val Arg Arg Gly           
                140                 145                 150               

tgg cgc tgc ggc tac ctc gag tgc tcc gcc aag tac aac tgg cac gtg       1014
Trp Arg Cys Gly Tyr Leu Glu Cys Ser Ala Lys Tyr Asn Trp His Val           
            155                 160                 165                   

ctg cgt ctc ttc cgc gag ctg ctg cgc tgc gct ctg gtg cgc gcg cgc       1062
Leu Arg Leu Phe Arg Glu Leu Leu Arg Cys Ala Leu Val Arg Ala Arg           
        170                 175                 180                       

cct gca cac ccg gcc ctg cgc ctg cag ggg gcg ctg cat ccc gcg cgc       1110
Pro Ala His Pro Ala Leu Arg Leu Gln Gly Ala Leu His Pro Ala Arg           
    185                 190                 195                           

tgc agc ctc atg tga cccgatcgga cagtgccatc catgggcccc accttgtgac       1165
Cys Ser Leu Met                                                           
200                                                                       

tgggacaatc agggacctgg attggacggg atcgcccaac ttcactggga ctggacaggg     1225

aagtctccgc cctgattgga tgaggaaagc tccaacccag tctcctaagc gactggcccc     1285

cttttgaacc tcattggacc caaccaggtc ccaagctcca ttggagatga ccagtccttt     1345

ctgggacctc aatgggtcac aatcccattg gatggaaagg acttggctat gaacttgact     1405

ggaaacacgc agcctgctcc tggagcttca ctggacatat tctttatgcc acacctacca     1465

cgggataata aaagggaaaa taatttgaaa aaaaaaaaca aaaaaaaaaa aaaa           1519


<210>  566
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  566

Met Gly Gly Ser Leu Arg Val Ala Val Leu Gly Ala Pro Gly Val Gly 
1               5                   10                  15      


Lys Thr Ala Ile Ile Arg Gln Phe Leu Phe Gly Asp Tyr Pro Glu Arg 
            20                  25                  30          


His Arg Pro Thr Asp Gly Pro Arg Leu Tyr Arg Pro Ala Val Leu Leu 
        35                  40                  45              


Asp Gly Ala Val Tyr Asp Leu Ser Ile Arg Asp Gly Asp Val Ala Gly 
    50                  55                  60                  


Pro Gly Ser Ser Pro Gly Gly Pro Glu Glu Trp Pro Asp Ala Lys Asp 
65                  70                  75                  80  


Trp Ser Leu Gln Asp Thr Asp Ala Phe Val Leu Val Tyr Asp Ile Cys 
                85                  90                  95      


Ser Pro Asp Ser Phe Asp Tyr Val Lys Ala Leu Arg Gln Arg Ile Ala 
            100                 105                 110         


Glu Thr Arg Pro Ala Gly Ala Pro Glu Ala Pro Ile Leu Val Val Gly 
        115                 120                 125             


Asn Lys Arg Asp Arg Gln Arg Leu Arg Phe Gly Pro Arg Arg Ala Leu 
    130                 135                 140                 


Ala Ala Leu Val Arg Arg Gly Trp Arg Cys Gly Tyr Leu Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Tyr Asn Trp His Val Leu Arg Leu Phe Arg Glu Leu Leu Arg 
                165                 170                 175     


Cys Ala Leu Val Arg Ala Arg Pro Ala His Pro Ala Leu Arg Leu Gln 
            180                 185                 190         


Gly Ala Leu His Pro Ala Arg Cys Ser Leu Met 
        195                 200             


<210>  567
<211>  7840
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (14)..(2140)

<400>  567
aacgggaaac aag atg gcg gct gca ggt ccg agt act cgg gcc tct tcc          49
               Met Ala Ala Ala Gly Pro Ser Thr Arg Ala Ser Ser            
               1               5                   10                     

gcg gcg gca gca gcc gct ctg agt cgg cgg ggc cgg cgg ggc cgc tgt         97
Ala Ala Ala Ala Ala Ala Leu Ser Arg Arg Gly Arg Arg Gly Arg Cys           
        15                  20                  25                        

gac gag acg gcg gca gct aag act ggg gcc cca ggc ccg gct tct gga        145
Asp Glu Thr Ala Ala Ala Lys Thr Gly Ala Pro Gly Pro Ala Ser Gly           
    30                  35                  40                            

cct tcg ctg ttg gtg ttg tcg ccg ccg ttg ctg cag ccg ccg ctg ccg        193
Pro Ser Leu Leu Val Leu Ser Pro Pro Leu Leu Gln Pro Pro Leu Pro           
45                  50                  55                  60            

ccg cgg ccg gag gaa tcg ggc tgc gcc ggg tgc ctg gag ccc ccc gga        241
Pro Arg Pro Glu Glu Ser Gly Cys Ala Gly Cys Leu Glu Pro Pro Gly           
                65                  70                  75                

gaa gca gcg gcc ctg ccg tgc ggc cac tcg ctt tgc cga ggc tgc gcc        289
Glu Ala Ala Ala Leu Pro Cys Gly His Ser Leu Cys Arg Gly Cys Ala           
            80                  85                  90                    

caa cgc gcc gcc gac gcg gcg ggc ccg ggt tgc cct cgc tgc cgc gcc        337
Gln Arg Ala Ala Asp Ala Ala Gly Pro Gly Cys Pro Arg Cys Arg Ala           
        95                  100                 105                       

cgc ggc cca ggc tgg gcc cgc cgt cgg gcc cgc gac gac ggc cag gcc        385
Arg Gly Pro Gly Trp Ala Arg Arg Arg Ala Arg Asp Asp Gly Gln Ala           
    110                 115                 120                           

gac tca gag gtg ctg ggc gag tgc gcc cgc cgc agc caa ccc gag cgc        433
Asp Ser Glu Val Leu Gly Glu Cys Ala Arg Arg Ser Gln Pro Glu Arg           
125                 130                 135                 140           

tgc cgc ccg cgc cgg gac ggg ggc gcg gct gcc gcg ggg ccc agg cca        481
Cys Arg Pro Arg Arg Asp Gly Gly Ala Ala Ala Ala Gly Pro Arg Pro           
                145                 150                 155               

gag cag gag ccg cgt gcc gcg cct gcg gag cca gac ttt ata ttc aga        529
Glu Gln Glu Pro Arg Ala Ala Pro Ala Glu Pro Asp Phe Ile Phe Arg           
            160                 165                 170                   

gca cca atc aaa tta agc aag cct ggg gaa ctt cgt gag gaa tat gaa        577
Ala Pro Ile Lys Leu Ser Lys Pro Gly Glu Leu Arg Glu Glu Tyr Glu           
        175                 180                 185                       

agc ttg aga aag ctg aga gaa gaa aag tta caa gag gaa aaa ccc tct        625
Ser Leu Arg Lys Leu Arg Glu Glu Lys Leu Gln Glu Glu Lys Pro Ser           
    190                 195                 200                           

gaa gat caa atc cac aag ctg tta cca gag gat aca gaa aca ggg aaa        673
Glu Asp Gln Ile His Lys Leu Leu Pro Glu Asp Thr Glu Thr Gly Lys           
205                 210                 215                 220           

agg aaa atg gat gaa cag aaa aaa aga gat gaa cca tta gta ctg aaa        721
Arg Lys Met Asp Glu Gln Lys Lys Arg Asp Glu Pro Leu Val Leu Lys           
                225                 230                 235               

aca aat ctg gaa cgt tgt cct gca cgt ctc tca gat tca gag aat gaa        769
Thr Asn Leu Glu Arg Cys Pro Ala Arg Leu Ser Asp Ser Glu Asn Glu           
            240                 245                 250                   

gaa cct tct cga ggc cag atg aca cag aca cat cgc tcg gca ttt gtt        817
Glu Pro Ser Arg Gly Gln Met Thr Gln Thr His Arg Ser Ala Phe Val           
        255                 260                 265                       

tcc aag aac aac tcc tac tcc tta gct ttc ctg gca ggg aag cta aac        865
Ser Lys Asn Asn Ser Tyr Ser Leu Ala Phe Leu Ala Gly Lys Leu Asn           
    270                 275                 280                           

tcc aag gtg gaa agg agt cag agc tgt agt gac aca gcc cag gaa aga        913
Ser Lys Val Glu Arg Ser Gln Ser Cys Ser Asp Thr Ala Gln Glu Arg           
285                 290                 295                 300           

gcg aag agc aga gtc aga gca gtt cca ggc aac aaa gcc aag gtc aca        961
Ala Lys Ser Arg Val Arg Ala Val Pro Gly Asn Lys Ala Lys Val Thr           
                305                 310                 315               

act atg act cca gcc tcc aac ccc atc att ggt gtc ctc ttg tca act       1009
Thr Met Thr Pro Ala Ser Asn Pro Ile Ile Gly Val Leu Leu Ser Thr           
            320                 325                 330                   

caa aac aac cgc tgc gtc tcg gcc cct gac tta acc atc gaa aag cgt       1057
Gln Asn Asn Arg Cys Val Ser Ala Pro Asp Leu Thr Ile Glu Lys Arg           
        335                 340                 345                       

cta ccc ttc agc tcc ctt tca tcc ttg gct tcc ctg cat aag cca gag       1105
Leu Pro Phe Ser Ser Leu Ser Ser Leu Ala Ser Leu His Lys Pro Glu           
    350                 355                 360                           

cgt tct gtc agc cct gag agc aat gac agc atc tcc gaa gaa cta aac       1153
Arg Ser Val Ser Pro Glu Ser Asn Asp Ser Ile Ser Glu Glu Leu Asn           
365                 370                 375                 380           

cat ttc aag ccc att gtc tgc tca cca tgt act cct ccc aag aga ctc       1201
His Phe Lys Pro Ile Val Cys Ser Pro Cys Thr Pro Pro Lys Arg Leu           
                385                 390                 395               

cct gat ggc cgt gtg cta agt cct ctc atc atc aaa tca act cca cgc       1249
Pro Asp Gly Arg Val Leu Ser Pro Leu Ile Ile Lys Ser Thr Pro Arg           
            400                 405                 410                   

aac cta aac aga agc ctg cag aag cag act tct tat gag gcc agt cca       1297
Asn Leu Asn Arg Ser Leu Gln Lys Gln Thr Ser Tyr Glu Ala Ser Pro           
        415                 420                 425                       

cgg atc ctc aaa aag tgg gaa cag atc ttt cag gag cgg cag atc aaa       1345
Arg Ile Leu Lys Lys Trp Glu Gln Ile Phe Gln Glu Arg Gln Ile Lys           
    430                 435                 440                           

aag acc ctt tca aaa gcc act ctt acc tct ctg gct cct gaa atg ggg       1393
Lys Thr Leu Ser Lys Ala Thr Leu Thr Ser Leu Ala Pro Glu Met Gly           
445                 450                 455                 460           

gaa gag tta cta ggc tct gaa ggt atc cat tct agc aag gag aag cca       1441
Glu Glu Leu Leu Gly Ser Glu Gly Ile His Ser Ser Lys Glu Lys Pro           
                465                 470                 475               

ctt gtg gct gta aat aca aga tta tct ggt ggg cag gtc ctc tct gag       1489
Leu Val Ala Val Asn Thr Arg Leu Ser Gly Gly Gln Val Leu Ser Glu           
            480                 485                 490                   

tat act gga ccc acc tct gct gat ctt gat cat ttc ccc tct gtt agc       1537
Tyr Thr Gly Pro Thr Ser Ala Asp Leu Asp His Phe Pro Ser Val Ser           
        495                 500                 505                       

caa aca aaa gca gaa cag gac agt gat aat aaa agt agc act gag atc       1585
Gln Thr Lys Ala Glu Gln Asp Ser Asp Asn Lys Ser Ser Thr Glu Ile           
    510                 515                 520                           

cca ctg gaa acc tgc tgt tcc tca gaa ctc aaa ggg gga ggc agt ggg       1633
Pro Leu Glu Thr Cys Cys Ser Ser Glu Leu Lys Gly Gly Gly Ser Gly           
525                 530                 535                 540           

act tct ttg gag agg gag cag ttt gag ggg tta ggg tca act cca gat       1681
Thr Ser Leu Glu Arg Glu Gln Phe Glu Gly Leu Gly Ser Thr Pro Asp           
                545                 550                 555               

gcc aag tta gac aaa acc tgt ata agc aga gcc atg aaa atc acc aca       1729
Ala Lys Leu Asp Lys Thr Cys Ile Ser Arg Ala Met Lys Ile Thr Thr           
            560                 565                 570                   

gtt aat tca gtg cta ccc caa aac agt gtt ttg ggt gga gtc ctc aaa       1777
Val Asn Ser Val Leu Pro Gln Asn Ser Val Leu Gly Gly Val Leu Lys           
        575                 580                 585                       

aca aag caa caa ttg aag aca tta aat cat ttt gat ctg act aat ggt       1825
Thr Lys Gln Gln Leu Lys Thr Leu Asn His Phe Asp Leu Thr Asn Gly           
    590                 595                 600                           

gtt cta gtt gag agc cta agt gaa gag cca ctt cct tct ttg cgt cga       1873
Val Leu Val Glu Ser Leu Ser Glu Glu Pro Leu Pro Ser Leu Arg Arg           
605                 610                 615                 620           

ggc cgg aaa aga cac tgc aag acc aag cac tta gaa caa aat ggc tcc       1921
Gly Arg Lys Arg His Cys Lys Thr Lys His Leu Glu Gln Asn Gly Ser           
                625                 630                 635               

ctt aaa aaa ctg cga caa acc agt ggg gag gtg ggt ctg gcc cca aca       1969
Leu Lys Lys Leu Arg Gln Thr Ser Gly Glu Val Gly Leu Ala Pro Thr           
            640                 645                 650                   

gac cca gtc ctg cga gag atg gag cag aag ctt cag caa gag gaa gaa       2017
Asp Pro Val Leu Arg Glu Met Glu Gln Lys Leu Gln Gln Glu Glu Glu           
        655                 660                 665                       

gac cga cag ttg gct ctg cag ttg cag cgc atg ttc gac aat gag agg       2065
Asp Arg Gln Leu Ala Leu Gln Leu Gln Arg Met Phe Asp Asn Glu Arg           
    670                 675                 680                           

cgg act gtg agc cgg cga aaa gga agt gtg gat cag tat ctc cta cgg       2113
Arg Thr Val Ser Arg Arg Lys Gly Ser Val Asp Gln Tyr Leu Leu Arg           
685                 690                 695                 700           

tcc agc aac atg gcc ggg gcc aag tag cacctaatga agtgttacct             2160
Ser Ser Asn Met Ala Gly Ala Lys                                           
                705                                                       

atttttaaaa ggtcttaggc cttgatcatt tatcctgaag agctgagtgt tctcactttg     2220

gttttatttt aatggcaaaa cactgtctaa tatggttctg agaggttcca gggcctttgt     2280

agtcaatatc caagggaaaa gcatctccgt ttctctgtga cccaggccag aagcctgagt     2340

gacccatccc taagggcttc tgggccaaac ctggcagcac ccactgggaa tgagatttgg     2400

aacggcctca ggagcataat ggccacagtt agtaatggta aagaggggat accttcttaa     2460

actgatagac ttcctgactt ctttcagcag ggtattgttt taaatcagcc ttgcagataa     2520

aaattaattc catctttttc agacaagtga acaatttagt tccttggcag atccaaaatg     2580

atagatggtt atgttacgct ttctgctgtc ccttgccaaa aataagtaaa tatatcagtt     2640

aagattatgc ctttacaaaa gttaatttac attctctgtt taaaaaataa tatttggtga     2700

atgctatata gttgacagag cacatttaca gaccttatta atttagtctt tccaagagac     2760

ctctcatgta actggcatta gccccatttt tagatgatga aactgcagtg cagatgttct     2820

ggttctctca actaccaagt ggcataaccc atggattttc taaaggtttc ccaaatagat     2880

cacaacctaa gggtgtgcca ggggagccta ggggaagcta ggctgggcat tgaacactga     2940

tagtgcagaa tccacatgca aacaagatcg acagggtgga taaacatata tgtgcattat     3000

ccccatcccc cacagtttag agccttctgc ttttctgggg gtttcagcct atgagacaaa     3060

ctataatcag gcttcattat tacttttcaa atggccaagg gttatctgca atgttgatct     3120

aaaatcctaa aaaatcaccc tgaagtcagg caaggaacaa tacttaaact ccatactatg     3180

gaaacaaggt atctagctgg atgcagctgg taaattcagt cccatggacc tttgggggtt     3240

tattttcctt agcagctgac accatgtgtc ttttgcatcc ctggtggtgc ttggtgcttc     3300

tgcccatctg ggctcattga gaatagggat gaagatatga ttttagggaa tttctgatgg     3360

gctggcatgc cccatgtagt atgagttact atataaagtc atgtgactgg cattttaaca     3420

gaccttccag agcttatata tcccaatata tgttgtttcc tttgagtagc cccagcagga     3480

tactgcttag tttttccagt gccattggtg aaagcatttc tggaactgtc ttcaaagact     3540

agaaacactg actcccaaaa tgctagaact ggaagggacc ttaatggtta tctattccag     3600

cctcctccta aggtcctcct cagcttctag acctagaagc caaagtccag aacagtgacc     3660

cattgatcaa ggcagatagt ataactcctt ttaagtgttc tcagatttgc cttttctcag     3720

ggcaaatctt cagtgttttg tggttatttg tggttgagag agagagagaa tgtaatgtct     3780

gagactagcc agcagctatt tgaagcctct gggaaagaag gtggcttatc aagtgggttt     3840

gtagtaatga gtgctgctgt aaagcagagc cattttcttg tgcagctcat agttcccaaa     3900

cagttcccaa acagaaattc cagagatgtc ttaaacattg tggtcatcat tgagataggt     3960

ggaatctctt tggtgactac gttggtgggg aacatcactc acctgaatgt atgcattctg     4020

tgttctctgt gtgtgtgcac atatgcagat gtatgtttta aaaacattta ccaaactcat     4080

gattttgtag tcacaccact tcagttctgg gccctaccaa caatttatgt cctccaagag     4140

ctgctggagg gcatgtttgt gcccaaaaca gaagagctgg ctctggttta cagaagacag     4200

ggagggtgac cttactataa atgcccttag aggaaactta tcagttactg ccatttcacg     4260

catttccttt ttgatcttag taaatattat tggaaggcta gtcttgttgg taggagcaaa     4320

gacacttatt tttccacttg ccatctttct ctatatctcc agtaatttga aaaacacttt     4380

tcagttggaa ttgatttttg tctttggtaa aaagaaatat ttttaataga taaaagatat     4440

atattttaaa tatttcccca aattaatact ttcattttaa gaattgcata gcagttgtaa     4500

caagtgcaga atgaagaaca aattcttgtt aagcaaatag tccaaactct aggtccagct     4560

tactgccttc cccccttgta cctacagtga tgcctaggat ggtattgaca gttgttttct     4620

aaacttcctg ctgagcaaca gtccttcaaa tataggtaga gtggtctagg ttaaggaggg     4680

aggagggttg atctttaatc aggttggctt tggaggaagg aaaaaccact aaggtattat     4740

ctgaatttta agatgcttcc catccttaat aactaaaacc tgaatgcttt tctttctgaa     4800

aaatctccct ctctccttcc atgattctga agttggttaa aagtcgatat gttgatgtgt     4860

attatttggg ggaacagaaa aggacaagga aggaaacaga acgatgggaa gggtttgtga     4920

gctagaataa gaggtgcagg atttcacaaa acaaattcct cacaaatcat tgaagcccag     4980

ttcaccatac aaattaccca tgtcttactc tgttccttgt atatatgcat tctgggtttt     5040

tttattatta aaggggaagt taggggggag ggtgaaggtc agtctgaggg gaaatccagg     5100

aaatgtggtg cccttagaag ggggctgtca gctcttttcc atagagaggg aaagaaactt     5160

tgagaaaatg ttcttgaccc attgattgta tctgctggaa gaagtcatct gggcctgttg     5220

ggttggtatc agatcagggg attatgcatc cagcccctgg cccctttaat ctatttgcct     5280

ctttttaaaa aaggttaagt cttcttgggt gaggcttgcc agggaaactc ctaagtggct     5340

tcacttattt tttaaatttt aatttaattt ttaaattttt gcttggaagc agcactggta     5400

ataaatgttt tattttttgt tcattttccc taaaggaaaa atgtccttaa gagattaaag     5460

ctcttaattg attactgtct ggttacaaac tggcaaactg actaaaatgg gaagctgcca     5520

ccgtgcctga ctcatgtagc tgatgaccga aggctcatcc tttcttttct atttgacaga     5580

catttactga gcttcagact tgagccaacc ctgagctgga ctgtggagat aaagcagttc     5640

ctgctcttga ggagctcaat gtctaatgga atgcatttga atgtatgtgt ggctggagag     5700

ttcatttatg gtcttaggaa agccatttct ggtcccattt agaaaactga ccagcaccca     5760

gcaagctgca ttctacattt tagagacccc attggtattt gtgaatttga ttgcaccacc     5820

gcttttcctt tactaagtaa tgttatggaa ggagaatgaa ttttctcctc tagtgattac     5880

aggacattaa catctcttca gaagctgctt ttagcttaag ccccaagaag tgaggtgggt     5940

tgtggatcac tgacatggtc aggggaggcc cacacctcaa ttcagtaacc acctaatctc     6000

tcccccaacc tgatctctca tcagagctgg cagcaacttg ggattccttt cctttttcct     6060

gcctaacttt tcattgaaat gtctagtagg agagtgagaa aagagaacaa aggctgggtc     6120

acagtcatag aatgttacag ctggaatggg catggaaatc atccaagtta aacttcttct     6180

ctgccccccg cccccacttt tttttttttt tttttttaac caaacgaact tgtgatccag     6240

tgccctattt tatagtgtgg ttttccaggg tctgaataaa taatcattaa agtttgacac     6300

acgcagacac acgcaccaat gatggggata cccccaaatg atttaggagg ttattttatt     6360

ttaatagttt tttcttcctg atttttttca gttagttaga gttaaatgta cctatagccc     6420

ctgaatacat gctcaggtag agaaagtctc catagtataa gtaagtaata tgaatgtgga     6480

atcttggaaa gtgatatatt ttgattggaa taattttaat taaatttaat gattttaatt     6540

aagaattaaa agccagctag ccaaattttc tttaaaaatt ggaaactcat tatggtctta     6600

aattgtcctc aggcagcctt ttcctcatca acccatagag tggtcttttg aactggtatc     6660

taaacatacc tggttatgaa ttctcaaaag agaaagcagg tctggggcgg ggtggtcagg     6720

agacagattc tagggaaagt gctgaagaga ttttcttctg aagatgatct aggaaatgca     6780

tctttataca tgattgttag ctgctgtagc tttctgaaga agattgtaga aaagagacta     6840

agatatatgc aagggtcacc agtttagaga tcagtcaaat tggaaaaagt gccaagactg     6900

gatgtgcaga ttgttctatg tattatcagt atttttttcc tcttaagaaa aaaatttact     6960

ctctctcctt tgtgagtaaa tgcctcctta atgcctttta agtaaggtgg caacttttaa     7020

ctgtcatctt gtgagaggca acctcaaact ctaagcagac tccctctctc cctttctggt     7080

gtcttaaatc aagaactagt ttgaagccaa ggcaaagcaa ggtttgttca tcttcctttc     7140

ctgtcattta aggtaaaaca ggcaatgaac tcgctcttca aataccatag ttcaagagta     7200

gctgttggcc ctggttccag attaatatag cagcaggcag attgcccctt cttggggcca     7260

ccaccctcca aagctgtgcc accaatgaga gcattgggtt caagtttgca tcaaacatgg     7320

tattaccaac gctgagcctc cagcagagca cttaaaagtc ctagtgagag aatagatact     7380

atgcaaggga aaaaaattta aatgccaacg aatagttttt ttttttttga acctgataca     7440

ctgtttgttt actctcaact ctttgtacaa atattattgt cctaagggcc ttttcccctc     7500

ctgcctagaa aataggttgt gtattggttt tattcaacct gctgtctgct ttaggattgg     7560

agaaggtacc tggatccttg tggactgcca ctgctggctg cctcctctcc aactcatcag     7620

aagagcattt tgacaaagac agaggacttg gaccagggca tgccctgttg gggatgtttc     7680

tgtcagcaag gacatggcat ggaatcaagt gggctgatgt gttgttattt aaacagtacc     7740

aaagtgcatt cttcaatgta tgtttgcctg cttgaagcaa ggcccaagtt gagaatacag     7800

taaaggaaac tcatgaaagt ggaaaaaaaa aaaaaaaaaa                           7840


<210>  568
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  568

Met Ala Ala Ala Gly Pro Ser Thr Arg Ala Ser Ser Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Leu Ser Arg Arg Gly Arg Arg Gly Arg Cys Asp Glu Thr Ala 
            20                  25                  30          


Ala Ala Lys Thr Gly Ala Pro Gly Pro Ala Ser Gly Pro Ser Leu Leu 
        35                  40                  45              


Val Leu Ser Pro Pro Leu Leu Gln Pro Pro Leu Pro Pro Arg Pro Glu 
    50                  55                  60                  


Glu Ser Gly Cys Ala Gly Cys Leu Glu Pro Pro Gly Glu Ala Ala Ala 
65                  70                  75                  80  


Leu Pro Cys Gly His Ser Leu Cys Arg Gly Cys Ala Gln Arg Ala Ala 
                85                  90                  95      


Asp Ala Ala Gly Pro Gly Cys Pro Arg Cys Arg Ala Arg Gly Pro Gly 
            100                 105                 110         


Trp Ala Arg Arg Arg Ala Arg Asp Asp Gly Gln Ala Asp Ser Glu Val 
        115                 120                 125             


Leu Gly Glu Cys Ala Arg Arg Ser Gln Pro Glu Arg Cys Arg Pro Arg 
    130                 135                 140                 


Arg Asp Gly Gly Ala Ala Ala Ala Gly Pro Arg Pro Glu Gln Glu Pro 
145                 150                 155                 160 


Arg Ala Ala Pro Ala Glu Pro Asp Phe Ile Phe Arg Ala Pro Ile Lys 
                165                 170                 175     


Leu Ser Lys Pro Gly Glu Leu Arg Glu Glu Tyr Glu Ser Leu Arg Lys 
            180                 185                 190         


Leu Arg Glu Glu Lys Leu Gln Glu Glu Lys Pro Ser Glu Asp Gln Ile 
        195                 200                 205             


His Lys Leu Leu Pro Glu Asp Thr Glu Thr Gly Lys Arg Lys Met Asp 
    210                 215                 220                 


Glu Gln Lys Lys Arg Asp Glu Pro Leu Val Leu Lys Thr Asn Leu Glu 
225                 230                 235                 240 


Arg Cys Pro Ala Arg Leu Ser Asp Ser Glu Asn Glu Glu Pro Ser Arg 
                245                 250                 255     


Gly Gln Met Thr Gln Thr His Arg Ser Ala Phe Val Ser Lys Asn Asn 
            260                 265                 270         


Ser Tyr Ser Leu Ala Phe Leu Ala Gly Lys Leu Asn Ser Lys Val Glu 
        275                 280                 285             


Arg Ser Gln Ser Cys Ser Asp Thr Ala Gln Glu Arg Ala Lys Ser Arg 
    290                 295                 300                 


Val Arg Ala Val Pro Gly Asn Lys Ala Lys Val Thr Thr Met Thr Pro 
305                 310                 315                 320 


Ala Ser Asn Pro Ile Ile Gly Val Leu Leu Ser Thr Gln Asn Asn Arg 
                325                 330                 335     


Cys Val Ser Ala Pro Asp Leu Thr Ile Glu Lys Arg Leu Pro Phe Ser 
            340                 345                 350         


Ser Leu Ser Ser Leu Ala Ser Leu His Lys Pro Glu Arg Ser Val Ser 
        355                 360                 365             


Pro Glu Ser Asn Asp Ser Ile Ser Glu Glu Leu Asn His Phe Lys Pro 
    370                 375                 380                 


Ile Val Cys Ser Pro Cys Thr Pro Pro Lys Arg Leu Pro Asp Gly Arg 
385                 390                 395                 400 


Val Leu Ser Pro Leu Ile Ile Lys Ser Thr Pro Arg Asn Leu Asn Arg 
                405                 410                 415     


Ser Leu Gln Lys Gln Thr Ser Tyr Glu Ala Ser Pro Arg Ile Leu Lys 
            420                 425                 430         


Lys Trp Glu Gln Ile Phe Gln Glu Arg Gln Ile Lys Lys Thr Leu Ser 
        435                 440                 445             


Lys Ala Thr Leu Thr Ser Leu Ala Pro Glu Met Gly Glu Glu Leu Leu 
    450                 455                 460                 


Gly Ser Glu Gly Ile His Ser Ser Lys Glu Lys Pro Leu Val Ala Val 
465                 470                 475                 480 


Asn Thr Arg Leu Ser Gly Gly Gln Val Leu Ser Glu Tyr Thr Gly Pro 
                485                 490                 495     


Thr Ser Ala Asp Leu Asp His Phe Pro Ser Val Ser Gln Thr Lys Ala 
            500                 505                 510         


Glu Gln Asp Ser Asp Asn Lys Ser Ser Thr Glu Ile Pro Leu Glu Thr 
        515                 520                 525             


Cys Cys Ser Ser Glu Leu Lys Gly Gly Gly Ser Gly Thr Ser Leu Glu 
    530                 535                 540                 


Arg Glu Gln Phe Glu Gly Leu Gly Ser Thr Pro Asp Ala Lys Leu Asp 
545                 550                 555                 560 


Lys Thr Cys Ile Ser Arg Ala Met Lys Ile Thr Thr Val Asn Ser Val 
                565                 570                 575     


Leu Pro Gln Asn Ser Val Leu Gly Gly Val Leu Lys Thr Lys Gln Gln 
            580                 585                 590         


Leu Lys Thr Leu Asn His Phe Asp Leu Thr Asn Gly Val Leu Val Glu 
        595                 600                 605             


Ser Leu Ser Glu Glu Pro Leu Pro Ser Leu Arg Arg Gly Arg Lys Arg 
    610                 615                 620                 


His Cys Lys Thr Lys His Leu Glu Gln Asn Gly Ser Leu Lys Lys Leu 
625                 630                 635                 640 


Arg Gln Thr Ser Gly Glu Val Gly Leu Ala Pro Thr Asp Pro Val Leu 
                645                 650                 655     


Arg Glu Met Glu Gln Lys Leu Gln Gln Glu Glu Glu Asp Arg Gln Leu 
            660                 665                 670         


Ala Leu Gln Leu Gln Arg Met Phe Asp Asn Glu Arg Arg Thr Val Ser 
        675                 680                 685             


Arg Arg Lys Gly Ser Val Asp Gln Tyr Leu Leu Arg Ser Ser Asn Met 
    690                 695                 700                 


Ala Gly Ala Lys 
705             


<210>  569
<211>  6551
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (719)..(4930)

<400>  569
tggcacagat ctccagaaac ccttgtaatt tcctgagtga caggggtgat agaaacatct       60

tttattagaa tacttggtct tggttcctga cacaagagct tctaagacct ttggaatctc      120

caagtgataa gagtgtatga cagtgagcta actggtggct gggatccttt agacaacttc      180

aggatggggg ctatcccctg aaagactaag gcatgattag aggtctggga tttgcagccc      240

cacgcctcga cctccagaga gggtaaaagg gctggagatt gattaaccac cagttgccag      300

tgatttaacc aatcatgcct aagtgatggc acctccatta aaaaataaac cacaggtttg      360

gagagctttc ggtttggtta accccaacca cataccaaga aggcgatgca cctcaaactg      420

catgaagaca aaaggtcctg tgctcacctg ggacccttct ggacgttgcc ctgtgtacct      480

cttcgactgc ctgttcatct acgacgaacc ccgggtattg accccagaca acaatgccac      540

ttcatattgg ggacttcgtc tgggattcca aggtgcattc attgcaaagt tccttaaata      600

ttttctcact gcttcctact aaaggacgga cagagcattt gttcttcagc cacatacttt      660

ccttccactg gccagcattc tcctctatta gactagaact gtggataaac ctcagaaa        718

atg gcc acc cag cag aaa gcc tct gac gag agg atc tcc cag ttt gat        766
Met Ala Thr Gln Gln Lys Ala Ser Asp Glu Arg Ile Ser Gln Phe Asp           
1               5                   10                  15                

cac aat ttg ctg cca gag ctg tct gct ctt ctg ggc cta gat gca gtt        814
His Asn Leu Leu Pro Glu Leu Ser Ala Leu Leu Gly Leu Asp Ala Val           
            20                  25                  30                    

cag ttg gca aag gaa cta gaa gaa gag gag cag aag gag cga gca aaa        862
Gln Leu Ala Lys Glu Leu Glu Glu Glu Glu Gln Lys Glu Arg Ala Lys           
        35                  40                  45                        

atg cag aaa ggc tac aac tct caa atg cgc agt gaa gca aaa agg tta        910
Met Gln Lys Gly Tyr Asn Ser Gln Met Arg Ser Glu Ala Lys Arg Leu           
    50                  55                  60                            

aag act ttt gtg act tat gag ccg tac agc tca tgg ata cca cag gag        958
Lys Thr Phe Val Thr Tyr Glu Pro Tyr Ser Ser Trp Ile Pro Gln Glu           
65                  70                  75                  80            

atg gcg gcc gct ggg ttt tac ttc act ggg gta aaa tct ggg att cag       1006
Met Ala Ala Ala Gly Phe Tyr Phe Thr Gly Val Lys Ser Gly Ile Gln           
                85                  90                  95                

tgc ttc tgc tgt agc cta atc ctc ttt ggt gcc ggc ctc acg aga ctc       1054
Cys Phe Cys Cys Ser Leu Ile Leu Phe Gly Ala Gly Leu Thr Arg Leu           
            100                 105                 110                   

ccc ata gaa gac cac aag agg ttt cat cca gat tgt ggg ttc ctt ttg       1102
Pro Ile Glu Asp His Lys Arg Phe His Pro Asp Cys Gly Phe Leu Leu           
        115                 120                 125                       

aac aag gat gtt ggt aac att gcc aag tac gac ata agg gtg aag aat       1150
Asn Lys Asp Val Gly Asn Ile Ala Lys Tyr Asp Ile Arg Val Lys Asn           
    130                 135                 140                           

ctg aag agc agg ctg aga gga ggt aaa atg agg tac caa gaa gag gag       1198
Leu Lys Ser Arg Leu Arg Gly Gly Lys Met Arg Tyr Gln Glu Glu Glu           
145                 150                 155                 160           

gct aga ctt gcg tcc ttc agg aac tgg cca ttt tat gtc caa ggg ata       1246
Ala Arg Leu Ala Ser Phe Arg Asn Trp Pro Phe Tyr Val Gln Gly Ile           
                165                 170                 175               

tcc cct tgt gtg ctc tca gag gct ggc ttt gtc ttt aca ggt aaa cag       1294
Ser Pro Cys Val Leu Ser Glu Ala Gly Phe Val Phe Thr Gly Lys Gln           
            180                 185                 190                   

gac acg gta cag tgt ttt tcc tgt ggt gga tgt tta gga aat tgg gaa       1342
Asp Thr Val Gln Cys Phe Ser Cys Gly Gly Cys Leu Gly Asn Trp Glu           
        195                 200                 205                       

gaa gga gat gat cct tgg aag gaa cat gcc aaa tgg ttc ccc aaa tgt       1390
Glu Gly Asp Asp Pro Trp Lys Glu His Ala Lys Trp Phe Pro Lys Cys           
    210                 215                 220                           

gaa ttt ctt cgg agt aag aaa tcc tca gag gaa att acc cag tat att       1438
Glu Phe Leu Arg Ser Lys Lys Ser Ser Glu Glu Ile Thr Gln Tyr Ile           
225                 230                 235                 240           

caa agc tac aag gga ttt gtt gac ata acg gga gaa cat ttt gtg aat       1486
Gln Ser Tyr Lys Gly Phe Val Asp Ile Thr Gly Glu His Phe Val Asn           
                245                 250                 255               

tcc tgg gtc cag aga gaa tta cct atg gca tca gct tat tgc aat gac       1534
Ser Trp Val Gln Arg Glu Leu Pro Met Ala Ser Ala Tyr Cys Asn Asp           
            260                 265                 270                   

agc atc ttt gct tac gaa gaa cta cgg ctg gac tct ttt aag gac tgg       1582
Ser Ile Phe Ala Tyr Glu Glu Leu Arg Leu Asp Ser Phe Lys Asp Trp           
        275                 280                 285                       

ccc cgg gaa tca gct gtg gga gtt gca gca ctg gcc aaa gca ggt ctt       1630
Pro Arg Glu Ser Ala Val Gly Val Ala Ala Leu Ala Lys Ala Gly Leu           
    290                 295                 300                           

ttc tac aca ggt ata aag gac atc gtc cag tgc ttt tcc tgt gga ggg       1678
Phe Tyr Thr Gly Ile Lys Asp Ile Val Gln Cys Phe Ser Cys Gly Gly           
305                 310                 315                 320           

tgt tta gag aaa tgg cag gaa ggt gat gac cca tta gac gat cac acc       1726
Cys Leu Glu Lys Trp Gln Glu Gly Asp Asp Pro Leu Asp Asp His Thr           
                325                 330                 335               

aga tgt ttt ccc aat tgt cca ttt ctc caa aat atg aag tcc tct gcg       1774
Arg Cys Phe Pro Asn Cys Pro Phe Leu Gln Asn Met Lys Ser Ser Ala           
            340                 345                 350                   

gaa gtg act cca gac ctt cag agc cgt ggt gaa ctt tgt gaa tta ctg       1822
Glu Val Thr Pro Asp Leu Gln Ser Arg Gly Glu Leu Cys Glu Leu Leu           
        355                 360                 365                       

gaa acc aca agt gaa agc aat ctt gaa gat tca ata gca gtt ggt cct       1870
Glu Thr Thr Ser Glu Ser Asn Leu Glu Asp Ser Ile Ala Val Gly Pro           
    370                 375                 380                           

ata gtg cca gaa atg gca cag ggt gaa gcc cag tgg ttt caa gag gca       1918
Ile Val Pro Glu Met Ala Gln Gly Glu Ala Gln Trp Phe Gln Glu Ala           
385                 390                 395                 400           

aag aat ctg aat gag cag ctg aga gca gct tat acc agc gcc agt ttc       1966
Lys Asn Leu Asn Glu Gln Leu Arg Ala Ala Tyr Thr Ser Ala Ser Phe           
                405                 410                 415               

cgc cac atg tct ttg ctt gat atc tct tcc gat ctg gcc acg gac cac       2014
Arg His Met Ser Leu Leu Asp Ile Ser Ser Asp Leu Ala Thr Asp His           
            420                 425                 430                   

ttg ctg ggc tgt gat ctg tct att gct tca aaa cac atc agc aaa cct       2062
Leu Leu Gly Cys Asp Leu Ser Ile Ala Ser Lys His Ile Ser Lys Pro           
        435                 440                 445                       

gtg caa gaa cct ctg gtg ctg cct gag gtc ttt ggc aac ttg aac tct       2110
Val Gln Glu Pro Leu Val Leu Pro Glu Val Phe Gly Asn Leu Asn Ser           
    450                 455                 460                           

gtc atg tgt gtg gag ggt gaa gct gga agt gga aag acg gtc ctc ctg       2158
Val Met Cys Val Glu Gly Glu Ala Gly Ser Gly Lys Thr Val Leu Leu           
465                 470                 475                 480           

aag aaa ata gct ttt ctg tgg gca tct gga tgc tgt ccc ctg tta aac       2206
Lys Lys Ile Ala Phe Leu Trp Ala Ser Gly Cys Cys Pro Leu Leu Asn           
                485                 490                 495               

agg ttc cag ctg gtt ttc tac ctc tcc ctt agt tcc acc aga cca gac       2254
Arg Phe Gln Leu Val Phe Tyr Leu Ser Leu Ser Ser Thr Arg Pro Asp           
            500                 505                 510                   

gag ggg ctg gcc agt atc atc tgt gac cag ctc cta gag aaa gaa gga       2302
Glu Gly Leu Ala Ser Ile Ile Cys Asp Gln Leu Leu Glu Lys Glu Gly           
        515                 520                 525                       

tct gtt act gaa atg tgc gtg agg aac att atc cag cag tta aag aat       2350
Ser Val Thr Glu Met Cys Val Arg Asn Ile Ile Gln Gln Leu Lys Asn           
    530                 535                 540                           

cag gtc tta ttc ctt tta gat gac tac aaa gaa ata tgt tca atc cct       2398
Gln Val Leu Phe Leu Leu Asp Asp Tyr Lys Glu Ile Cys Ser Ile Pro           
545                 550                 555                 560           

caa gtc ata gga aaa ctg att caa aaa aac cac tta tcc cgg acc tgc       2446
Gln Val Ile Gly Lys Leu Ile Gln Lys Asn His Leu Ser Arg Thr Cys           
                565                 570                 575               

cta ttg att gct gtc cgt aca aac agg gcc agg gac atc cgc cga tac       2494
Leu Leu Ile Ala Val Arg Thr Asn Arg Ala Arg Asp Ile Arg Arg Tyr           
            580                 585                 590                   

cta gag acc att cta gag atc aaa gca ttt ccc ttt tat aat act gtc       2542
Leu Glu Thr Ile Leu Glu Ile Lys Ala Phe Pro Phe Tyr Asn Thr Val           
        595                 600                 605                       

tgt ata tta cgg aag ctc ttt tca cat aat atg act cgt ctg cga aag       2590
Cys Ile Leu Arg Lys Leu Phe Ser His Asn Met Thr Arg Leu Arg Lys           
    610                 615                 620                           

ttt atg gtt tac ttt gga aag aac caa agt ttg cag aag ata cag aaa       2638
Phe Met Val Tyr Phe Gly Lys Asn Gln Ser Leu Gln Lys Ile Gln Lys           
625                 630                 635                 640           

act cct ctc ttt gtg gcg gcg atc tgt gct cat tgg ttt cag tat cct       2686
Thr Pro Leu Phe Val Ala Ala Ile Cys Ala His Trp Phe Gln Tyr Pro           
                645                 650                 655               

ttt gac cca tcc ttt gat gat gtg gct gtt ttc aag tcc tat atg gaa       2734
Phe Asp Pro Ser Phe Asp Asp Val Ala Val Phe Lys Ser Tyr Met Glu           
            660                 665                 670                   

cgc ctt tcc tta agg aac aaa gcg aca gct gaa att ctc aaa gca act       2782
Arg Leu Ser Leu Arg Asn Lys Ala Thr Ala Glu Ile Leu Lys Ala Thr           
        675                 680                 685                       

gtg tcc tcc tgt ggt gag ctg gcc ttg aaa ggg ttt ttt tca tgt tgc       2830
Val Ser Ser Cys Gly Glu Leu Ala Leu Lys Gly Phe Phe Ser Cys Cys           
    690                 695                 700                           

ttt gag ttt aat gat gat gat ctc gca gaa gca ggg gtt gat gaa gat       2878
Phe Glu Phe Asn Asp Asp Asp Leu Ala Glu Ala Gly Val Asp Glu Asp           
705                 710                 715                 720           

gaa gat cta acc atg tgc ttg atg agc aaa ttt aca gcc cag aga cta       2926
Glu Asp Leu Thr Met Cys Leu Met Ser Lys Phe Thr Ala Gln Arg Leu           
                725                 730                 735               

aga cca ttc tac cgg ttt tta agt cct gcc ttc caa gaa ttt ctt gcg       2974
Arg Pro Phe Tyr Arg Phe Leu Ser Pro Ala Phe Gln Glu Phe Leu Ala           
            740                 745                 750                   

ggg atg agg ctg att gaa ctc ctg gat tca gat agg cag gaa cat caa       3022
Gly Met Arg Leu Ile Glu Leu Leu Asp Ser Asp Arg Gln Glu His Gln           
        755                 760                 765                       

gat ttg gga ctg tat cat ttg aaa caa atc aac tca ccc atg atg act       3070
Asp Leu Gly Leu Tyr His Leu Lys Gln Ile Asn Ser Pro Met Met Thr           
    770                 775                 780                           

gta agc gcc tac aac aat ttt ttg aac tat gtc tcc agc ctc cct tca       3118
Val Ser Ala Tyr Asn Asn Phe Leu Asn Tyr Val Ser Ser Leu Pro Ser           
785                 790                 795                 800           

aca aaa gca ggg ccc aaa att gtg tct cat ttg ctc cat tta gtg gat       3166
Thr Lys Ala Gly Pro Lys Ile Val Ser His Leu Leu His Leu Val Asp           
                805                 810                 815               

aac aaa gag tca ttg gag aat ata tct gaa aat gat gac tac tta aag       3214
Asn Lys Glu Ser Leu Glu Asn Ile Ser Glu Asn Asp Asp Tyr Leu Lys           
            820                 825                 830                   

cac cag cca gaa att tca ctg cag atg cag tta ctt agg gga ttg tgg       3262
His Gln Pro Glu Ile Ser Leu Gln Met Gln Leu Leu Arg Gly Leu Trp           
        835                 840                 845                       

caa att tgt cca caa gct tac ttt tca atg gtt tca gaa cat tta ctg       3310
Gln Ile Cys Pro Gln Ala Tyr Phe Ser Met Val Ser Glu His Leu Leu           
    850                 855                 860                           

gtt ctt gcc ctg aaa act gct tat caa agc aac act gtt gct gcg tgt       3358
Val Leu Ala Leu Lys Thr Ala Tyr Gln Ser Asn Thr Val Ala Ala Cys           
865                 870                 875                 880           

tct cca ttt gtt ttg caa ttc ctt caa ggg aga aca ctg act ttg ggt       3406
Ser Pro Phe Val Leu Gln Phe Leu Gln Gly Arg Thr Leu Thr Leu Gly           
                885                 890                 895               

gcg ctt aac tta cag tac ttt ttc gac cac cca gaa agc ttg tca ttg       3454
Ala Leu Asn Leu Gln Tyr Phe Phe Asp His Pro Glu Ser Leu Ser Leu           
            900                 905                 910                   

ttg agg agc atc cac ttc cca ata cga gga aat aag aca tca ccc aga       3502
Leu Arg Ser Ile His Phe Pro Ile Arg Gly Asn Lys Thr Ser Pro Arg           
        915                 920                 925                       

gca cat ttt tca gtt ctg gaa aca tgt ttt gac aaa tca cag gtg cca       3550
Ala His Phe Ser Val Leu Glu Thr Cys Phe Asp Lys Ser Gln Val Pro           
    930                 935                 940                           

act ata gat cag gac tat gct tct gcc ttt gaa cct atg aat gaa tgg       3598
Thr Ile Asp Gln Asp Tyr Ala Ser Ala Phe Glu Pro Met Asn Glu Trp           
945                 950                 955                 960           

gag cga aat tta gct gaa aaa gag gat aat gta aag agc tat atg gat       3646
Glu Arg Asn Leu Ala Glu Lys Glu Asp Asn Val Lys Ser Tyr Met Asp           
                965                 970                 975               

atg cag cgc agg gca tca cca gac ctt agt act ggc tat tgg aaa ctt       3694
Met Gln Arg Arg Ala Ser Pro Asp Leu Ser Thr Gly Tyr Trp Lys Leu           
            980                 985                 990                   

tct cca aag cag tac aag att ccc  tgt cta gaa gtc gat  gtg aat gat     3742
Ser Pro Lys Gln Tyr Lys Ile Pro  Cys Leu Glu Val Asp  Val Asn Asp         
        995                 1000                 1005                     

att gat  gtt gta ggc cag gat  atg ctt gag att cta  atg aca gtt        3787
Ile Asp  Val Val Gly Gln Asp  Met Leu Glu Ile Leu  Met Thr Val            
    1010                 1015                 1020                        

ttc tca  gct tca cag cgc atc  gaa ctc cat tta aac  cac agc aga        3832
Phe Ser  Ala Ser Gln Arg Ile  Glu Leu His Leu Asn  His Ser Arg            
    1025                 1030                 1035                        

ggc ttt  ata gaa agc atc cgc  cca gct ctt gag ctg  tct aag gcc        3877
Gly Phe  Ile Glu Ser Ile Arg  Pro Ala Leu Glu Leu  Ser Lys Ala            
    1040                 1045                 1050                        

tct gtc  acc aag tgc tcc ata  agc aag ttg gaa ctc  agc gca gcc        3922
Ser Val  Thr Lys Cys Ser Ile  Ser Lys Leu Glu Leu  Ser Ala Ala            
    1055                 1060                 1065                        

gaa cag  gaa ctg ctt ctc acc  ctg cct tcc ctg gaa  tct ctt gaa        3967
Glu Gln  Glu Leu Leu Leu Thr  Leu Pro Ser Leu Glu  Ser Leu Glu            
    1070                 1075                 1080                        

gtc tca  ggg aca atc cag tca  caa gac caa atc ttt  cct aat ctg        4012
Val Ser  Gly Thr Ile Gln Ser  Gln Asp Gln Ile Phe  Pro Asn Leu            
    1085                 1090                 1095                        

gat aag  ttc ctg tgc ctg aaa  gaa ctg tct gtg gat  ctg gag ggc        4057
Asp Lys  Phe Leu Cys Leu Lys  Glu Leu Ser Val Asp  Leu Glu Gly            
    1100                 1105                 1110                        

aat ata  aat gtt ttt tca gtc  att cct gaa gaa ttt  cca aac ttc        4102
Asn Ile  Asn Val Phe Ser Val  Ile Pro Glu Glu Phe  Pro Asn Phe            
    1115                 1120                 1125                        

cac cat  atg gag aaa tta ttg  atc caa att tca gct  gag tat gat        4147
His His  Met Glu Lys Leu Leu  Ile Gln Ile Ser Ala  Glu Tyr Asp            
    1130                 1135                 1140                        

cct tcc  aaa cta gta aaa tta  att caa aat tct cca  aac ctt cat        4192
Pro Ser  Lys Leu Val Lys Leu  Ile Gln Asn Ser Pro  Asn Leu His            
    1145                 1150                 1155                        

gtt ttc  cat ctg aag tgt aac  ttc ttt tcg gat ttt  ggg tct ctc        4237
Val Phe  His Leu Lys Cys Asn  Phe Phe Ser Asp Phe  Gly Ser Leu            
    1160                 1165                 1170                        

atg act  atg ctt gtt tcc tgt  aag aaa ctc aca gaa  att aag ttt        4282
Met Thr  Met Leu Val Ser Cys  Lys Lys Leu Thr Glu  Ile Lys Phe            
    1175                 1180                 1185                        

tcg gat  tca ttt ttt caa gcc  gtc cca ttt gtt gcc  agt ttg cca        4327
Ser Asp  Ser Phe Phe Gln Ala  Val Pro Phe Val Ala  Ser Leu Pro            
    1190                 1195                 1200                        

aat ttt  att tct ctg aag ata  tta aat ctt gaa ggc  cag caa ttt        4372
Asn Phe  Ile Ser Leu Lys Ile  Leu Asn Leu Glu Gly  Gln Gln Phe            
    1205                 1210                 1215                        

cct gat  gag gaa aca tca gaa  aaa ttt gcc tac att  tta ggt tct        4417
Pro Asp  Glu Glu Thr Ser Glu  Lys Phe Ala Tyr Ile  Leu Gly Ser            
    1220                 1225                 1230                        

ctt agt  aac ctg gaa gaa ttg  atc ctt cct act ggg  gat gga att        4462
Leu Ser  Asn Leu Glu Glu Leu  Ile Leu Pro Thr Gly  Asp Gly Ile            
    1235                 1240                 1245                        

tat cga  gtg gcc aaa ctg atc  atc cag cag tgt cag  cag ctt cat        4507
Tyr Arg  Val Ala Lys Leu Ile  Ile Gln Gln Cys Gln  Gln Leu His            
    1250                 1255                 1260                        

tgt ctc  cga gtc ctc tca ttt  ttc aag act ttg aat  gat gac agc        4552
Cys Leu  Arg Val Leu Ser Phe  Phe Lys Thr Leu Asn  Asp Asp Ser            
    1265                 1270                 1275                        

gtg gtg  gaa att gcc aaa gta  gca atc agt gga ggt  ttc cag aaa        4597
Val Val  Glu Ile Ala Lys Val  Ala Ile Ser Gly Gly  Phe Gln Lys            
    1280                 1285                 1290                        

ctt gag  aac cta aag ctt tca  atc aat cac aag att  aca gag gaa        4642
Leu Glu  Asn Leu Lys Leu Ser  Ile Asn His Lys Ile  Thr Glu Glu            
    1295                 1300                 1305                        

gga tac  aga aat ttc ttt caa  gca ctg gac aac atg  cca aac ttg        4687
Gly Tyr  Arg Asn Phe Phe Gln  Ala Leu Asp Asn Met  Pro Asn Leu            
    1310                 1315                 1320                        

cag gag  ttg gac atc tcc agg  cat ttc aca gag tgt  atc aaa gct        4732
Gln Glu  Leu Asp Ile Ser Arg  His Phe Thr Glu Cys  Ile Lys Ala            
    1325                 1330                 1335                        

cag gcc  aca aca gtc aag tct  ttg agt caa tgt gtg  tta cga cta        4777
Gln Ala  Thr Thr Val Lys Ser  Leu Ser Gln Cys Val  Leu Arg Leu            
    1340                 1345                 1350                        

cca agg  ctc att aga ctg aac  atg tta agt tgg ctc  ttg gat gca        4822
Pro Arg  Leu Ile Arg Leu Asn  Met Leu Ser Trp Leu  Leu Asp Ala            
    1355                 1360                 1365                        

gat gat  att gca ttg ctt aat  gtc atg aaa gaa aga  cat cct caa        4867
Asp Asp  Ile Ala Leu Leu Asn  Val Met Lys Glu Arg  His Pro Gln            
    1370                 1375                 1380                        

tct aag  tac tta act att ctc  cag aaa tgg ata ctg  ccg ttc tct        4912
Ser Lys  Tyr Leu Thr Ile Leu  Gln Lys Trp Ile Leu  Pro Phe Ser            
    1385                 1390                 1395                        

cca atc  att cag aaa taa aagattcagc taaaaactgc tgaatcaata             4960
Pro Ile  Ile Gln Lys                                                      
    1400                                                                  

atttgtcttg gggcatattg aggatgtaaa aaaagttgtt gattaatgct aaaaaccaaa     5020

ttatccaaaa ttattttatt aaatattgca tacaaaagaa aatgtgtaag gcttgctaaa     5080

aaacaaaaca aaacaaaaca cagtcctgca tactcaccac caagctcaag aaataaatca     5140

tcaccaatac ctttgaggtc cctgagtaat ccaccccagc taaaggcaaa cccttcaatc     5200

aagtttatac agcaaaccct ccattgtcca tggtcaacag ggaaggggtt ggggacaggt     5260

ctgccaatct atctaaaagc cacaatatgg aagaagtatt caatttatat aataaatggc     5320

taacttaacg gttgaatcac tttcatacat ggatgaaacg ggtttaacac aggatccaca     5380

tgaatcttct gtgggccaag agatgttcct taatccttgt agaacctgtt ttctatattg     5440

aactagcttt ggtacagtag agttaactta ctttccattt atccactgcc aatataaaga     5500

ggaaacaggg gttagggaaa aatgacttca ttccagaggc ttctcagagt tcaacatatg     5560

ctataattta gaattttctt atgaatccac tctacttggg tagaaaatat tttatctcta     5620

gtgattgcat attatttcca tatcatagta tttcatagta ttatatttga tatgagtgtc     5680

tatatcaatg tcagtgtcca gaatttcgtt cctaccagtt aagtagtttt ctgaacggcc     5740

agaagaccat tcgaaattca tgatactact ataagttggt aaacaaccat acttttatcc     5800

tcatttttat tctcactaag aaaaaagtca actcccctcc ccttgcccaa gtatgaaata     5860

tagggacagt atgtatggtg tggtctcatt tgtttagaaa accacttatg actgggtgcg     5920

gtggctcaca cctgtaatcc cagcactttg ggaggctgag gcgggcgaat catttgaggt     5980

gaggaattcg agaccagcct ggccagcatg gtgaaacccc atctctacta aaaatacaaa     6040

aattagccag gtgtggtggc acatgcctgt agtcccagcc actagggcgg ctgagacgca     6100

agacttgctt gaacccggga ggcagaggtt gcagtgagcc aagatggcgc cactgcattc     6160

cagcctgggc aacagagcaa gaccctgtct gtctcaaaac aaaaaacaaa accacttata     6220

ttgctagcta cattaagaat ttctgaatat gttactgagc ttgcttgtgg taaccattta     6280

taatatcaga aagtatatgt acaccaaaac atgttgaaca tccatgttgt acaactgaaa     6340

tataaataat tttgtcaatt atacctaaat aaaactggaa aaaaatttct ggaagtttat     6400

atctaaaaat gttaatagtg cgtacctcta ggaagtgggc ctggaagcca ttcttacttt     6460

tcagtctctc ccattctgta ctgttttttg ttttactttc gtgcctgcat tatttttcta     6520

tttaaaacaa aaataaatct agtttagcac t                                    6551


<210>  570
<211>  1403
<212>  PRT
<213>  Homo sapiens

<400>  570

Met Ala Thr Gln Gln Lys Ala Ser Asp Glu Arg Ile Ser Gln Phe Asp 
1               5                   10                  15      


His Asn Leu Leu Pro Glu Leu Ser Ala Leu Leu Gly Leu Asp Ala Val 
            20                  25                  30          


Gln Leu Ala Lys Glu Leu Glu Glu Glu Glu Gln Lys Glu Arg Ala Lys 
        35                  40                  45              


Met Gln Lys Gly Tyr Asn Ser Gln Met Arg Ser Glu Ala Lys Arg Leu 
    50                  55                  60                  


Lys Thr Phe Val Thr Tyr Glu Pro Tyr Ser Ser Trp Ile Pro Gln Glu 
65                  70                  75                  80  


Met Ala Ala Ala Gly Phe Tyr Phe Thr Gly Val Lys Ser Gly Ile Gln 
                85                  90                  95      


Cys Phe Cys Cys Ser Leu Ile Leu Phe Gly Ala Gly Leu Thr Arg Leu 
            100                 105                 110         


Pro Ile Glu Asp His Lys Arg Phe His Pro Asp Cys Gly Phe Leu Leu 
        115                 120                 125             


Asn Lys Asp Val Gly Asn Ile Ala Lys Tyr Asp Ile Arg Val Lys Asn 
    130                 135                 140                 


Leu Lys Ser Arg Leu Arg Gly Gly Lys Met Arg Tyr Gln Glu Glu Glu 
145                 150                 155                 160 


Ala Arg Leu Ala Ser Phe Arg Asn Trp Pro Phe Tyr Val Gln Gly Ile 
                165                 170                 175     


Ser Pro Cys Val Leu Ser Glu Ala Gly Phe Val Phe Thr Gly Lys Gln 
            180                 185                 190         


Asp Thr Val Gln Cys Phe Ser Cys Gly Gly Cys Leu Gly Asn Trp Glu 
        195                 200                 205             


Glu Gly Asp Asp Pro Trp Lys Glu His Ala Lys Trp Phe Pro Lys Cys 
    210                 215                 220                 


Glu Phe Leu Arg Ser Lys Lys Ser Ser Glu Glu Ile Thr Gln Tyr Ile 
225                 230                 235                 240 


Gln Ser Tyr Lys Gly Phe Val Asp Ile Thr Gly Glu His Phe Val Asn 
                245                 250                 255     


Ser Trp Val Gln Arg Glu Leu Pro Met Ala Ser Ala Tyr Cys Asn Asp 
            260                 265                 270         


Ser Ile Phe Ala Tyr Glu Glu Leu Arg Leu Asp Ser Phe Lys Asp Trp 
        275                 280                 285             


Pro Arg Glu Ser Ala Val Gly Val Ala Ala Leu Ala Lys Ala Gly Leu 
    290                 295                 300                 


Phe Tyr Thr Gly Ile Lys Asp Ile Val Gln Cys Phe Ser Cys Gly Gly 
305                 310                 315                 320 


Cys Leu Glu Lys Trp Gln Glu Gly Asp Asp Pro Leu Asp Asp His Thr 
                325                 330                 335     


Arg Cys Phe Pro Asn Cys Pro Phe Leu Gln Asn Met Lys Ser Ser Ala 
            340                 345                 350         


Glu Val Thr Pro Asp Leu Gln Ser Arg Gly Glu Leu Cys Glu Leu Leu 
        355                 360                 365             


Glu Thr Thr Ser Glu Ser Asn Leu Glu Asp Ser Ile Ala Val Gly Pro 
    370                 375                 380                 


Ile Val Pro Glu Met Ala Gln Gly Glu Ala Gln Trp Phe Gln Glu Ala 
385                 390                 395                 400 


Lys Asn Leu Asn Glu Gln Leu Arg Ala Ala Tyr Thr Ser Ala Ser Phe 
                405                 410                 415     


Arg His Met Ser Leu Leu Asp Ile Ser Ser Asp Leu Ala Thr Asp His 
            420                 425                 430         


Leu Leu Gly Cys Asp Leu Ser Ile Ala Ser Lys His Ile Ser Lys Pro 
        435                 440                 445             


Val Gln Glu Pro Leu Val Leu Pro Glu Val Phe Gly Asn Leu Asn Ser 
    450                 455                 460                 


Val Met Cys Val Glu Gly Glu Ala Gly Ser Gly Lys Thr Val Leu Leu 
465                 470                 475                 480 


Lys Lys Ile Ala Phe Leu Trp Ala Ser Gly Cys Cys Pro Leu Leu Asn 
                485                 490                 495     


Arg Phe Gln Leu Val Phe Tyr Leu Ser Leu Ser Ser Thr Arg Pro Asp 
            500                 505                 510         


Glu Gly Leu Ala Ser Ile Ile Cys Asp Gln Leu Leu Glu Lys Glu Gly 
        515                 520                 525             


Ser Val Thr Glu Met Cys Val Arg Asn Ile Ile Gln Gln Leu Lys Asn 
    530                 535                 540                 


Gln Val Leu Phe Leu Leu Asp Asp Tyr Lys Glu Ile Cys Ser Ile Pro 
545                 550                 555                 560 


Gln Val Ile Gly Lys Leu Ile Gln Lys Asn His Leu Ser Arg Thr Cys 
                565                 570                 575     


Leu Leu Ile Ala Val Arg Thr Asn Arg Ala Arg Asp Ile Arg Arg Tyr 
            580                 585                 590         


Leu Glu Thr Ile Leu Glu Ile Lys Ala Phe Pro Phe Tyr Asn Thr Val 
        595                 600                 605             


Cys Ile Leu Arg Lys Leu Phe Ser His Asn Met Thr Arg Leu Arg Lys 
    610                 615                 620                 


Phe Met Val Tyr Phe Gly Lys Asn Gln Ser Leu Gln Lys Ile Gln Lys 
625                 630                 635                 640 


Thr Pro Leu Phe Val Ala Ala Ile Cys Ala His Trp Phe Gln Tyr Pro 
                645                 650                 655     


Phe Asp Pro Ser Phe Asp Asp Val Ala Val Phe Lys Ser Tyr Met Glu 
            660                 665                 670         


Arg Leu Ser Leu Arg Asn Lys Ala Thr Ala Glu Ile Leu Lys Ala Thr 
        675                 680                 685             


Val Ser Ser Cys Gly Glu Leu Ala Leu Lys Gly Phe Phe Ser Cys Cys 
    690                 695                 700                 


Phe Glu Phe Asn Asp Asp Asp Leu Ala Glu Ala Gly Val Asp Glu Asp 
705                 710                 715                 720 


Glu Asp Leu Thr Met Cys Leu Met Ser Lys Phe Thr Ala Gln Arg Leu 
                725                 730                 735     


Arg Pro Phe Tyr Arg Phe Leu Ser Pro Ala Phe Gln Glu Phe Leu Ala 
            740                 745                 750         


Gly Met Arg Leu Ile Glu Leu Leu Asp Ser Asp Arg Gln Glu His Gln 
        755                 760                 765             


Asp Leu Gly Leu Tyr His Leu Lys Gln Ile Asn Ser Pro Met Met Thr 
    770                 775                 780                 


Val Ser Ala Tyr Asn Asn Phe Leu Asn Tyr Val Ser Ser Leu Pro Ser 
785                 790                 795                 800 


Thr Lys Ala Gly Pro Lys Ile Val Ser His Leu Leu His Leu Val Asp 
                805                 810                 815     


Asn Lys Glu Ser Leu Glu Asn Ile Ser Glu Asn Asp Asp Tyr Leu Lys 
            820                 825                 830         


His Gln Pro Glu Ile Ser Leu Gln Met Gln Leu Leu Arg Gly Leu Trp 
        835                 840                 845             


Gln Ile Cys Pro Gln Ala Tyr Phe Ser Met Val Ser Glu His Leu Leu 
    850                 855                 860                 


Val Leu Ala Leu Lys Thr Ala Tyr Gln Ser Asn Thr Val Ala Ala Cys 
865                 870                 875                 880 


Ser Pro Phe Val Leu Gln Phe Leu Gln Gly Arg Thr Leu Thr Leu Gly 
                885                 890                 895     


Ala Leu Asn Leu Gln Tyr Phe Phe Asp His Pro Glu Ser Leu Ser Leu 
            900                 905                 910         


Leu Arg Ser Ile His Phe Pro Ile Arg Gly Asn Lys Thr Ser Pro Arg 
        915                 920                 925             


Ala His Phe Ser Val Leu Glu Thr Cys Phe Asp Lys Ser Gln Val Pro 
    930                 935                 940                 


Thr Ile Asp Gln Asp Tyr Ala Ser Ala Phe Glu Pro Met Asn Glu Trp 
945                 950                 955                 960 


Glu Arg Asn Leu Ala Glu Lys Glu Asp Asn Val Lys Ser Tyr Met Asp 
                965                 970                 975     


Met Gln Arg Arg Ala Ser Pro Asp Leu Ser Thr Gly Tyr Trp Lys Leu 
            980                 985                 990         


Ser Pro Lys Gln Tyr Lys Ile Pro  Cys Leu Glu Val Asp  Val Asn Asp 
        995                 1000                 1005             


Ile Asp  Val Val Gly Gln Asp  Met Leu Glu Ile Leu  Met Thr Val 
    1010                 1015                 1020             


Phe Ser  Ala Ser Gln Arg Ile  Glu Leu His Leu Asn  His Ser Arg 
    1025                 1030                 1035             


Gly Phe  Ile Glu Ser Ile Arg  Pro Ala Leu Glu Leu  Ser Lys Ala 
    1040                 1045                 1050             


Ser Val  Thr Lys Cys Ser Ile  Ser Lys Leu Glu Leu  Ser Ala Ala 
    1055                 1060                 1065             


Glu Gln  Glu Leu Leu Leu Thr  Leu Pro Ser Leu Glu  Ser Leu Glu 
    1070                 1075                 1080             


Val Ser  Gly Thr Ile Gln Ser  Gln Asp Gln Ile Phe  Pro Asn Leu 
    1085                 1090                 1095             


Asp Lys  Phe Leu Cys Leu Lys  Glu Leu Ser Val Asp  Leu Glu Gly 
    1100                 1105                 1110             


Asn Ile  Asn Val Phe Ser Val  Ile Pro Glu Glu Phe  Pro Asn Phe 
    1115                 1120                 1125             


His His  Met Glu Lys Leu Leu  Ile Gln Ile Ser Ala  Glu Tyr Asp 
    1130                 1135                 1140             


Pro Ser  Lys Leu Val Lys Leu  Ile Gln Asn Ser Pro  Asn Leu His 
    1145                 1150                 1155             


Val Phe  His Leu Lys Cys Asn  Phe Phe Ser Asp Phe  Gly Ser Leu 
    1160                 1165                 1170             


Met Thr  Met Leu Val Ser Cys  Lys Lys Leu Thr Glu  Ile Lys Phe 
    1175                 1180                 1185             


Ser Asp  Ser Phe Phe Gln Ala  Val Pro Phe Val Ala  Ser Leu Pro 
    1190                 1195                 1200             


Asn Phe  Ile Ser Leu Lys Ile  Leu Asn Leu Glu Gly  Gln Gln Phe 
    1205                 1210                 1215             


Pro Asp  Glu Glu Thr Ser Glu  Lys Phe Ala Tyr Ile  Leu Gly Ser 
    1220                 1225                 1230             


Leu Ser  Asn Leu Glu Glu Leu  Ile Leu Pro Thr Gly  Asp Gly Ile 
    1235                 1240                 1245             


Tyr Arg  Val Ala Lys Leu Ile  Ile Gln Gln Cys Gln  Gln Leu His 
    1250                 1255                 1260             


Cys Leu  Arg Val Leu Ser Phe  Phe Lys Thr Leu Asn  Asp Asp Ser 
    1265                 1270                 1275             


Val Val  Glu Ile Ala Lys Val  Ala Ile Ser Gly Gly  Phe Gln Lys 
    1280                 1285                 1290             


Leu Glu  Asn Leu Lys Leu Ser  Ile Asn His Lys Ile  Thr Glu Glu 
    1295                 1300                 1305             


Gly Tyr  Arg Asn Phe Phe Gln  Ala Leu Asp Asn Met  Pro Asn Leu 
    1310                 1315                 1320             


Gln Glu  Leu Asp Ile Ser Arg  His Phe Thr Glu Cys  Ile Lys Ala 
    1325                 1330                 1335             


Gln Ala  Thr Thr Val Lys Ser  Leu Ser Gln Cys Val  Leu Arg Leu 
    1340                 1345                 1350             


Pro Arg  Leu Ile Arg Leu Asn  Met Leu Ser Trp Leu  Leu Asp Ala 
    1355                 1360                 1365             


Asp Asp  Ile Ala Leu Leu Asn  Val Met Lys Glu Arg  His Pro Gln 
    1370                 1375                 1380             


Ser Lys  Tyr Leu Thr Ile Leu  Gln Lys Trp Ile Leu  Pro Phe Ser 
    1385                 1390                 1395             


Pro Ile  Ile Gln Lys 
    1400             


<210>  571
<211>  2951
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (464)..(2179)

<400>  571
ctttgggtta tgtcgtcatg aagccggcgc tctacagttg tgtaaccttg aacaaatggg       60

ttcagtatct tggaatttca gttttgtcat cgtttaaaaa atagatctgg aaaaatgtga      120

acgcacaccg tgcatagtgg tgaagactga acgagctgat aaagttttta ccattgtttt      180

atgaggattt tatttacaga gtaattgatt ttcctcgcag gtggcacctg gtaaatggtt      240

agcccttgcg gagaaacacc ctgttagttc ccagggagag attggcgccc tggagagtga      300

ttaccagtgt gcctttccat tatggtgtgt cacaggtgcc gcaagataag cctgattttt      360

catgactgct ttttcctgcc cttctgtgcc ctcaggacac tgcccatctc taagataaga      420

gcctggaaag aggactctgt tggctgttgg aaattgcaga gta atg cct cag gtg        475
                                                Met Pro Gln Val           
                                                1                         

aca ttt aat gat gtg gct ata gac ttc act cat gaa gag tgg gga tgg        523
Thr Phe Asn Asp Val Ala Ile Asp Phe Thr His Glu Glu Trp Gly Trp           
5                   10                  15                  20            

ctc agt tct gct cag agg gac tta tac aag gat gtg atg gtc cag aat        571
Leu Ser Ser Ala Gln Arg Asp Leu Tyr Lys Asp Val Met Val Gln Asn           
                25                  30                  35                

tat gag aac ctg gtc tct gta gca ggt ctt tct gta act aag cca tat        619
Tyr Glu Asn Leu Val Ser Val Ala Gly Leu Ser Val Thr Lys Pro Tyr           
            40                  45                  50                    

gtg atc acg tta ttg gag gat gga aaa gag ccc tgg atg atg gag aaa        667
Val Ile Thr Leu Leu Glu Asp Gly Lys Glu Pro Trp Met Met Glu Lys           
        55                  60                  65                        

aaa ctg tca aaa ggt atg att cca gat tgg gaa tca aga tgg gaa aac        715
Lys Leu Ser Lys Gly Met Ile Pro Asp Trp Glu Ser Arg Trp Glu Asn           
    70                  75                  80                            

aag gaa tta tca aca aag aag gat aat tat gat gaa gat tca ccc caa        763
Lys Glu Leu Ser Thr Lys Lys Asp Asn Tyr Asp Glu Asp Ser Pro Gln           
85                  90                  95                  100           

aca gta ata ata gaa aaa gtt gta aaa caa agt tat gaa ttt tca aat        811
Thr Val Ile Ile Glu Lys Val Val Lys Gln Ser Tyr Glu Phe Ser Asn           
                105                 110                 115               

tct aag aag aat ttg gaa tat ata gag aag ttg gaa ggg aag cat gga        859
Ser Lys Lys Asn Leu Glu Tyr Ile Glu Lys Leu Glu Gly Lys His Gly           
            120                 125                 130                   

agt cag gta gac cat ttc aga cca gca att ctc acc tct aga gaa agc        907
Ser Gln Val Asp His Phe Arg Pro Ala Ile Leu Thr Ser Arg Glu Ser           
        135                 140                 145                       

ccc act gca gac agt gtt tac aaa tac aat ata ttt aga agc acc ttt        955
Pro Thr Ala Asp Ser Val Tyr Lys Tyr Asn Ile Phe Arg Ser Thr Phe           
    150                 155                 160                           

cat tca aag tct act ctt tct gaa cca caa aaa att tct gct gaa ggg       1003
His Ser Lys Ser Thr Leu Ser Glu Pro Gln Lys Ile Ser Ala Glu Gly           
165                 170                 175                 180           

aat tca cac aaa tat gat ata tta aag aag aac tta cca aaa aag tca       1051
Asn Ser His Lys Tyr Asp Ile Leu Lys Lys Asn Leu Pro Lys Lys Ser           
                185                 190                 195               

gtt ata aaa aat gag aaa gtc aat ggt gga aag aaa ctt ttg aat tct       1099
Val Ile Lys Asn Glu Lys Val Asn Gly Gly Lys Lys Leu Leu Asn Ser           
            200                 205                 210                   

aat aaa agt ggg gca gcc ttc agc cag ggc aaa tct ctt acc ctt ccc       1147
Asn Lys Ser Gly Ala Ala Phe Ser Gln Gly Lys Ser Leu Thr Leu Pro           
        215                 220                 225                       

cag act tgt aat aga gag aaa atc tat aca tgc agt gaa tgt ggg aaa       1195
Gln Thr Cys Asn Arg Glu Lys Ile Tyr Thr Cys Ser Glu Cys Gly Lys           
    230                 235                 240                           

gcc ttt ggc aaa cag tca atc ctc aat cgc cac tgg aga att cat aca       1243
Ala Phe Gly Lys Gln Ser Ile Leu Asn Arg His Trp Arg Ile His Thr           
245                 250                 255                 260           

gga gag aag ccc tat gaa tgt cgt gaa tgt ggg aag act ttt agc cat       1291
Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Thr Phe Ser His           
                265                 270                 275               

ggc tca tcc ctt aca cga cat ctg ata agc cat agt gga gag aaa cct       1339
Gly Ser Ser Leu Thr Arg His Leu Ile Ser His Ser Gly Glu Lys Pro           
            280                 285                 290                   

tac aaa tgt att gaa tgt ggg aag gcc ttt agc cat gtc tca tca ctt       1387
Tyr Lys Cys Ile Glu Cys Gly Lys Ala Phe Ser His Val Ser Ser Leu           
        295                 300                 305                       

act aac cat cag agc act cac act gga gag aaa cca tat gaa tgt atg       1435
Thr Asn His Gln Ser Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Met           
    310                 315                 320                           

aac tgt gga aag tct ttt agt cgt gtg tcc cat ctt att gaa cat cta       1483
Asn Cys Gly Lys Ser Phe Ser Arg Val Ser His Leu Ile Glu His Leu           
325                 330                 335                 340           

aga att cat act caa gaa aaa ctc tat gag tgt cgt ata tgt gga aag       1531
Arg Ile His Thr Gln Glu Lys Leu Tyr Glu Cys Arg Ile Cys Gly Lys           
                345                 350                 355               

gcc ttc att cat agg tca tct ctc att cac cat cag aaa atc cat act       1579
Ala Phe Ile His Arg Ser Ser Leu Ile His His Gln Lys Ile His Thr           
            360                 365                 370                   

gga gag aag cct tat gaa tgt aga gaa tgt ggg aaa gct ttc tgc tgt       1627
Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Ala Phe Cys Cys           
        375                 380                 385                       

agc tca cac ctt act cga cat caa aga att cac act atg gag aaa caa       1675
Ser Ser His Leu Thr Arg His Gln Arg Ile His Thr Met Glu Lys Gln           
    390                 395                 400                           

tat gaa tgc aac aaa tgt ctg aaa gtc ttt agt agc ctc tca ttt ctt       1723
Tyr Glu Cys Asn Lys Cys Leu Lys Val Phe Ser Ser Leu Ser Phe Leu           
405                 410                 415                 420           

gtt cag cat cag agt att cat act gaa gaa aaa ccc ttt gaa tgt cag       1771
Val Gln His Gln Ser Ile His Thr Glu Glu Lys Pro Phe Glu Cys Gln           
                425                 430                 435               

aaa tgc agg aaa tcc ttc aac cag ctt gaa tca ctg aat atg cat ttg       1819
Lys Cys Arg Lys Ser Phe Asn Gln Leu Glu Ser Leu Asn Met His Leu           
            440                 445                 450                   

aga aat cac att aga ttg aaa ccc tac gaa tgc agt ata tgt ggg aaa       1867
Arg Asn His Ile Arg Leu Lys Pro Tyr Glu Cys Ser Ile Cys Gly Lys           
        455                 460                 465                       

gcc ttt agt cat agg tca tcc ctg ctt caa cat cac aga att cat act       1915
Ala Phe Ser His Arg Ser Ser Leu Leu Gln His His Arg Ile His Thr           
    470                 475                 480                           

gga gag aaa cct tat gaa tgt att aaa tgt ggg aag acc ttc agc tgt       1963
Gly Glu Lys Pro Tyr Glu Cys Ile Lys Cys Gly Lys Thr Phe Ser Cys           
485                 490                 495                 500           

agt tca aac ctt acc gta cat cag aga att cac act gga gaa aag cca       2011
Ser Ser Asn Leu Thr Val His Gln Arg Ile His Thr Gly Glu Lys Pro           
                505                 510                 515               

tat aaa tgt aat gag tgt ggg aaa gct ttt agc aaa ggc tca aat ctt       2059
Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ser Lys Gly Ser Asn Leu           
            520                 525                 530                   

act gcc cat caa aga gta cat aat gga gag aaa ccc aat agt gtg gta       2107
Thr Ala His Gln Arg Val His Asn Gly Glu Lys Pro Asn Ser Val Val           
        535                 540                 545                       

agt gtg gaa aag cct tta gac tat atg aat cac tat aca tgt gag aaa       2155
Ser Val Glu Lys Pro Leu Asp Tyr Met Asn His Tyr Thr Cys Glu Lys           
    550                 555                 560                           

tct tac aga aga gaa act gta tga agcagtggtt atcatggtaa atttcctaga      2209
Ser Tyr Arg Arg Glu Thr Val                                               
565                 570                                                   

ttctccctta tttaacatta gaaaaattta tactggggaa agtcttatga atgtggtgaa     2269

tataggaaga ccttttagca aagatgcagg ccagtttgtt tattagactt tatactgtag     2329

agaaatcata tgaagaccat aaatgtggga aagcctttgt cagtattaat cccttaattg     2389

acataagtat actcacacta ggataaaacc ctgtacatgt agcaaatgtg ggaaagacta     2449

cagacaatag gaatctttta caaactccta caggagagaa gctgtatgaa tgtagaaaat     2509

ttagaaattg agggaagtct tcagttccaa gtatatccct tattctacag cagagaactc     2569

aaaatggaga gaaatctcat ttaagagatg tagcaaagtg ttcactaaga gtgtttatct     2629

tggtacacat cagaagatta atggtagaac aacctgaagg atttaggagt tatgtgtaaa     2689

tctttgcagt catgctattt gtaaactgga ttctacagga gagcaaataa acattataat     2749

aaaatatgca tttcttagag cagtagcttg cagtttcagt tgagttctac ttagaaattc     2809

tttttagcta gtgggcatgt gaagatattt agtcacccag aggagccagt aagtgttata     2869

atattgaaaa ttaaagctgc aaaagaaata aagtgatgtt aataaaagtt ttggcatcta     2929

ataaaatcat tttgtatatc ac                                              2951


<210>  572
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  572

Met Pro Gln Val Thr Phe Asn Asp Val Ala Ile Asp Phe Thr His Glu 
1               5                   10                  15      


Glu Trp Gly Trp Leu Ser Ser Ala Gln Arg Asp Leu Tyr Lys Asp Val 
            20                  25                  30          


Met Val Gln Asn Tyr Glu Asn Leu Val Ser Val Ala Gly Leu Ser Val 
        35                  40                  45              


Thr Lys Pro Tyr Val Ile Thr Leu Leu Glu Asp Gly Lys Glu Pro Trp 
    50                  55                  60                  


Met Met Glu Lys Lys Leu Ser Lys Gly Met Ile Pro Asp Trp Glu Ser 
65                  70                  75                  80  


Arg Trp Glu Asn Lys Glu Leu Ser Thr Lys Lys Asp Asn Tyr Asp Glu 
                85                  90                  95      


Asp Ser Pro Gln Thr Val Ile Ile Glu Lys Val Val Lys Gln Ser Tyr 
            100                 105                 110         


Glu Phe Ser Asn Ser Lys Lys Asn Leu Glu Tyr Ile Glu Lys Leu Glu 
        115                 120                 125             


Gly Lys His Gly Ser Gln Val Asp His Phe Arg Pro Ala Ile Leu Thr 
    130                 135                 140                 


Ser Arg Glu Ser Pro Thr Ala Asp Ser Val Tyr Lys Tyr Asn Ile Phe 
145                 150                 155                 160 


Arg Ser Thr Phe His Ser Lys Ser Thr Leu Ser Glu Pro Gln Lys Ile 
                165                 170                 175     


Ser Ala Glu Gly Asn Ser His Lys Tyr Asp Ile Leu Lys Lys Asn Leu 
            180                 185                 190         


Pro Lys Lys Ser Val Ile Lys Asn Glu Lys Val Asn Gly Gly Lys Lys 
        195                 200                 205             


Leu Leu Asn Ser Asn Lys Ser Gly Ala Ala Phe Ser Gln Gly Lys Ser 
    210                 215                 220                 


Leu Thr Leu Pro Gln Thr Cys Asn Arg Glu Lys Ile Tyr Thr Cys Ser 
225                 230                 235                 240 


Glu Cys Gly Lys Ala Phe Gly Lys Gln Ser Ile Leu Asn Arg His Trp 
                245                 250                 255     


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys 
            260                 265                 270         


Thr Phe Ser His Gly Ser Ser Leu Thr Arg His Leu Ile Ser His Ser 
        275                 280                 285             


Gly Glu Lys Pro Tyr Lys Cys Ile Glu Cys Gly Lys Ala Phe Ser His 
    290                 295                 300                 


Val Ser Ser Leu Thr Asn His Gln Ser Thr His Thr Gly Glu Lys Pro 
305                 310                 315                 320 


Tyr Glu Cys Met Asn Cys Gly Lys Ser Phe Ser Arg Val Ser His Leu 
                325                 330                 335     


Ile Glu His Leu Arg Ile His Thr Gln Glu Lys Leu Tyr Glu Cys Arg 
            340                 345                 350         


Ile Cys Gly Lys Ala Phe Ile His Arg Ser Ser Leu Ile His His Gln 
        355                 360                 365             


Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys 
    370                 375                 380                 


Ala Phe Cys Cys Ser Ser His Leu Thr Arg His Gln Arg Ile His Thr 
385                 390                 395                 400 


Met Glu Lys Gln Tyr Glu Cys Asn Lys Cys Leu Lys Val Phe Ser Ser 
                405                 410                 415     


Leu Ser Phe Leu Val Gln His Gln Ser Ile His Thr Glu Glu Lys Pro 
            420                 425                 430         


Phe Glu Cys Gln Lys Cys Arg Lys Ser Phe Asn Gln Leu Glu Ser Leu 
        435                 440                 445             


Asn Met His Leu Arg Asn His Ile Arg Leu Lys Pro Tyr Glu Cys Ser 
    450                 455                 460                 


Ile Cys Gly Lys Ala Phe Ser His Arg Ser Ser Leu Leu Gln His His 
465                 470                 475                 480 


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Lys Cys Gly Lys 
                485                 490                 495     


Thr Phe Ser Cys Ser Ser Asn Leu Thr Val His Gln Arg Ile His Thr 
            500                 505                 510         


Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ser Lys 
        515                 520                 525             


Gly Ser Asn Leu Thr Ala His Gln Arg Val His Asn Gly Glu Lys Pro 
    530                 535                 540                 


Asn Ser Val Val Ser Val Glu Lys Pro Leu Asp Tyr Met Asn His Tyr 
545                 550                 555                 560 


Thr Cys Glu Lys Ser Tyr Arg Arg Glu Thr Val 
                565                 570     


<210>  573
<211>  2400
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (494)..(1144)

<400>  573
gacaggtgag cgacgaactt ctgagacagg tgtgggtgcg agggtcggga gggtcatggg       60

attgggaccg aggtgtgagg agggaatctg caattccttg ctacacagag cgctggcaac      120

ttctgacagg ctgtttctgg ggtatgggct gcctcgggtt gttgctgtta caaggaaaga      180

aaagagttcc cctgcccacc gcctcccagc cactgggcta cctcctggca ggaaatttgc      240

aaactgagtt taacaagtta ggatcagcag agggtagagg agggccctgg cagatgtggg      300

gtctagaaga ggacaggagt tatcagggcc tccggccatt gtgctgggcc tttgcctgta      360

caattgtttc tcaagcagtt gtgtccctgt ggctttggtg cgcctgtgtg cactttctcc      420

ctccacctgg agcatgggct aacaccggag gaaaggaaaa gacagagtca gacagggagc      480

ctggggaggg gcc atg gtg cca atg cac tta ctg ggg aga ctg gag aag         529
               Met Val Pro Met His Leu Leu Gly Arg Leu Glu Lys            
               1               5                   10                     

ccg ctt ctc ctc ctg tgc tgc gcc tcc ttc cta ctg ggg ctg gct ttg        577
Pro Leu Leu Leu Leu Cys Cys Ala Ser Phe Leu Leu Gly Leu Ala Leu           
        15                  20                  25                        

ctg ggc ata aag acg gac atc acc ccc gtt gct tat ttc ttt ctc aca        625
Leu Gly Ile Lys Thr Asp Ile Thr Pro Val Ala Tyr Phe Phe Leu Thr           
    30                  35                  40                            

ttg ggt ggc ttc ttc ttg ttt gcc tat ctc ctg gtc cgg ttt ctg gaa        673
Leu Gly Gly Phe Phe Leu Phe Ala Tyr Leu Leu Val Arg Phe Leu Glu           
45                  50                  55                  60            

tgg ggg ctt cgg tcc cag ctc caa tca atg cag act gag agc cca ggg        721
Trp Gly Leu Arg Ser Gln Leu Gln Ser Met Gln Thr Glu Ser Pro Gly           
                65                  70                  75                

ccc tca ggc aat gca cgg gac aat gaa gcc ttt gaa gtg cca gtc tat        769
Pro Ser Gly Asn Ala Arg Asp Asn Glu Ala Phe Glu Val Pro Val Tyr           
            80                  85                  90                    

gaa gag gcc gtg gtg gga cta gaa tcc cag tgc cgc ccc caa gag ttg        817
Glu Glu Ala Val Val Gly Leu Glu Ser Gln Cys Arg Pro Gln Glu Leu           
        95                  100                 105                       

gac caa cca ccc ccc tac agc act gtt gtg ata ccc cca gca cct gag        865
Asp Gln Pro Pro Pro Tyr Ser Thr Val Val Ile Pro Pro Ala Pro Glu           
    110                 115                 120                           

gag gaa caa cct agc cat cca gag ggg tcc agg aga gcc aaa ctg gaa        913
Glu Glu Gln Pro Ser His Pro Glu Gly Ser Arg Arg Ala Lys Leu Glu           
125                 130                 135                 140           

cag agg cga atg gcc tca gag ggg tcc atg gcc cag gaa gga agc cct        961
Gln Arg Arg Met Ala Ser Glu Gly Ser Met Ala Gln Glu Gly Ser Pro           
                145                 150                 155               

gga aga gct cca atc aac ctt cgg ctt cgg gga cca cgg gct gtg tcc       1009
Gly Arg Ala Pro Ile Asn Leu Arg Leu Arg Gly Pro Arg Ala Val Ser           
            160                 165                 170                   

act gct cct gat ctg cag agc ttg gcg gca gtc ccc aca tta gag cct       1057
Thr Ala Pro Asp Leu Gln Ser Leu Ala Ala Val Pro Thr Leu Glu Pro           
        175                 180                 185                       

ctg act cca ccc cct gcc tat gat gtc tgc ttt ggt cac cct gat gat       1105
Leu Thr Pro Pro Pro Ala Tyr Asp Val Cys Phe Gly His Pro Asp Asp           
    190                 195                 200                           

gat agt gtt ttt tat gag gac aac tgg gca ccc cct taa atgactctcc        1154
Asp Ser Val Phe Tyr Glu Asp Asn Trp Ala Pro Pro                           
205                 210                 215                               

caagatttct cttctctcca caccagacct cgttcatttg actaacattt tccagcgcct     1214

actatgtgtc agaaacaagt gtttctgcct ggacatcata aatggggact tggaccctga     1274

ggagagtcag gccacggtaa gcccttccca gctgagatat gggtggcata atttgagtct     1334

tctggcaaca tttggtgacc taccccatat ccaatatttc cagcgttaga ttgaggatga     1394

ggtagggagg tgatccagag aaggcggaga aggaagaagt aacctctgag tggcggctat     1454

tgcttctgtt ccaggtgctg ttcgagctgt tagaaccctt aggcttgaca gctttgtgag     1514

ttattattga aaaatgagga ttccaagagt cagaggagtt tgataatgtg cacgagggca     1574

cactgctagt aaataacatt aaaataactg gaatgaactc ctgatcccaa agcctattgt     1634

gttttcaaca caaggtaata ggaagccaag caacttgcat gtctcccaat ccctgtctag     1694

ggacagctgc tggtgcagga tggaagactt cctataaaca gaatgggcga ccaattgtgt     1754

ctacagaggg ggtgggctga gcatgggcac gcatgtcccc agcctcctgg acgagcaaag     1814

tcagtcaaag cgctggtgat ccctgctccg cgtgcgtagc agtgtctgtg cctctcctgc     1874

ccaggggcta gagagcagtc tccagtgcag ggtccccatc ctatctgaaa acagtggagt     1934

cagtgacccc aggtggaggg acttccagtt ttaacaatgg gttggtatga aggccagaag     1994

gagtgaaaca tgtgaacttt ctggcgagga gactccctct tgaatcatcc atatgtagcc     2054

ccggggtcac ttgcgaagag tctctaacag cttctgcctc actcctaagc tctgaccgct     2114

aggctttcac cccagccgcc ggtcctgatt cctgagatcc caatattgag caccaggttt     2174

cctggaattg tgtgctgcgg ctgtgatgta ggtttcggtc gctggaagct gctaaaccat     2234

agctgacgcc ccctcctaag ccagccttcc ttccccgcgc gggcatctgt ccagggcctt     2294

gtcgcgctct cagtctcctt cgcagcctgg ccccaaccgt tcaacttcaa taaagcaaaa     2354

ctccagccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                    2400


<210>  574
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  574

Met Val Pro Met His Leu Leu Gly Arg Leu Glu Lys Pro Leu Leu Leu 
1               5                   10                  15      


Leu Cys Cys Ala Ser Phe Leu Leu Gly Leu Ala Leu Leu Gly Ile Lys 
            20                  25                  30          


Thr Asp Ile Thr Pro Val Ala Tyr Phe Phe Leu Thr Leu Gly Gly Phe 
        35                  40                  45              


Phe Leu Phe Ala Tyr Leu Leu Val Arg Phe Leu Glu Trp Gly Leu Arg 
    50                  55                  60                  


Ser Gln Leu Gln Ser Met Gln Thr Glu Ser Pro Gly Pro Ser Gly Asn 
65                  70                  75                  80  


Ala Arg Asp Asn Glu Ala Phe Glu Val Pro Val Tyr Glu Glu Ala Val 
                85                  90                  95      


Val Gly Leu Glu Ser Gln Cys Arg Pro Gln Glu Leu Asp Gln Pro Pro 
            100                 105                 110         


Pro Tyr Ser Thr Val Val Ile Pro Pro Ala Pro Glu Glu Glu Gln Pro 
        115                 120                 125             


Ser His Pro Glu Gly Ser Arg Arg Ala Lys Leu Glu Gln Arg Arg Met 
    130                 135                 140                 


Ala Ser Glu Gly Ser Met Ala Gln Glu Gly Ser Pro Gly Arg Ala Pro 
145                 150                 155                 160 


Ile Asn Leu Arg Leu Arg Gly Pro Arg Ala Val Ser Thr Ala Pro Asp 
                165                 170                 175     


Leu Gln Ser Leu Ala Ala Val Pro Thr Leu Glu Pro Leu Thr Pro Pro 
            180                 185                 190         


Pro Ala Tyr Asp Val Cys Phe Gly His Pro Asp Asp Asp Ser Val Phe 
        195                 200                 205             


Tyr Glu Asp Asn Trp Ala Pro Pro 
    210                 215     


<210>  575
<211>  1740
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (49)..(1596)

<400>  575
gccctcgcgc tgtcgccgcc acagtctgcg acgggacccg gcgtgccc atg tgt cag        57
                                                     Met Cys Gln          
                                                     1                    

gtg ggc gag gac tac ggg gag ccg gcg cct gag gag ccg ccc ccg gcg        105
Val Gly Glu Asp Tyr Gly Glu Pro Ala Pro Glu Glu Pro Pro Pro Ala           
    5                   10                  15                            

ccg cgg ccc agc cgt gag cag aag tgt gtg aag tgc aag gaa gcg cag        153
Pro Arg Pro Ser Arg Glu Gln Lys Cys Val Lys Cys Lys Glu Ala Gln           
20                  25                  30                  35            

ccc gtt gtg gtg ata cga gcc gga gat gcc ttc tgc agg gac tgt ttc        201
Pro Val Val Val Ile Arg Ala Gly Asp Ala Phe Cys Arg Asp Cys Phe           
                40                  45                  50                

aag gcc ttc tac gtc cac aag ttc aga gcc atg ctg ggc aag aac cgg        249
Lys Ala Phe Tyr Val His Lys Phe Arg Ala Met Leu Gly Lys Asn Arg           
            55                  60                  65                    

ctc atc ttt cca ggc gag aag gtg ctc ttg gcg tgg tct ggg ggg cct        297
Leu Ile Phe Pro Gly Glu Lys Val Leu Leu Ala Trp Ser Gly Gly Pro           
        70                  75                  80                        

tcg tcc agc tcc atg gtc tgg cag gtt ctt gag ggc ctg agc caa gat        345
Ser Ser Ser Ser Met Val Trp Gln Val Leu Glu Gly Leu Ser Gln Asp           
    85                  90                  95                            

tct gcc aaa aga ctg cgc ttt gtg gca gga gtc atc ttt gtt gac gag        393
Ser Ala Lys Arg Leu Arg Phe Val Ala Gly Val Ile Phe Val Asp Glu           
100                 105                 110                 115           

gga gca gcc tgt ggc cag agc cta gag gag aga tca aag acc ctg gcc        441
Gly Ala Ala Cys Gly Gln Ser Leu Glu Glu Arg Ser Lys Thr Leu Ala           
                120                 125                 130               

gaa gtg aag ccc att ctg caa gca act ggg ttc cca tgg cat gtg gtg        489
Glu Val Lys Pro Ile Leu Gln Ala Thr Gly Phe Pro Trp His Val Val           
            135                 140                 145                   

gcc tta gag gag gtg ttc agc ctg cca ccg tcg gtg ctt tgg tgc tct        537
Ala Leu Glu Glu Val Phe Ser Leu Pro Pro Ser Val Leu Trp Cys Ser           
        150                 155                 160                       

gcc cag gag ctg gtg gga tcc gag ggg gcc tac aag gcg gcc gtg gac        585
Ala Gln Glu Leu Val Gly Ser Glu Gly Ala Tyr Lys Ala Ala Val Asp           
    165                 170                 175                           

agc ttc ctc cag cag cag cat gtg ctg ggg gcc ggg ggt ggt cct ggc        633
Ser Phe Leu Gln Gln Gln His Val Leu Gly Ala Gly Gly Gly Pro Gly           
180                 185                 190                 195           

ccg act caa ggg gag gaa cag cca ccc cag ccc ccg ctg gac ccc cag        681
Pro Thr Gln Gly Glu Glu Gln Pro Pro Gln Pro Pro Leu Asp Pro Gln           
                200                 205                 210               

aac ctg gca aga ccg cct gcc cct gcc cag act gag gct ctt tcc caa        729
Asn Leu Ala Arg Pro Pro Ala Pro Ala Gln Thr Glu Ala Leu Ser Gln           
            215                 220                 225                   

ctg ttc tgc tca gtg agg aca ctg act gcc aag gag gag ctt ctg cag        777
Leu Phe Cys Ser Val Arg Thr Leu Thr Ala Lys Glu Glu Leu Leu Gln           
        230                 235                 240                       

acc ctg cgg acc cac ctg atc ctc cac atg gcc cga gcc cac ggc tac        825
Thr Leu Arg Thr His Leu Ile Leu His Met Ala Arg Ala His Gly Tyr           
    245                 250                 255                           

tcc aag gtc atg act ggg gac agc tgc aca cgc ttg gct atc aag ctc        873
Ser Lys Val Met Thr Gly Asp Ser Cys Thr Arg Leu Ala Ile Lys Leu           
260                 265                 270                 275           

atg acc aac ctg gcg ctg ggt cga ggg gcc ttc ctg gcc tgg gat acg        921
Met Thr Asn Leu Ala Leu Gly Arg Gly Ala Phe Leu Ala Trp Asp Thr           
                280                 285                 290               

ggc ttc tcg gat gag cgg cac ggg gac gtg gtg gtg gtg cgg ccc atg        969
Gly Phe Ser Asp Glu Arg His Gly Asp Val Val Val Val Arg Pro Met           
            295                 300                 305                   

cgg gac cac acc ctg aag gag gtc gct ttc tac aac cgc ctg ttc tcc       1017
Arg Asp His Thr Leu Lys Glu Val Ala Phe Tyr Asn Arg Leu Phe Ser           
        310                 315                 320                       

gtt cct tct gtc ttc aca cca gcc gtc gac acc aag gcc cct gaa aag       1065
Val Pro Ser Val Phe Thr Pro Ala Val Asp Thr Lys Ala Pro Glu Lys           
    325                 330                 335                           

gcc agc atc cac cgg ctg atg gag gcc ttc atc ctc agg ctg cag acc       1113
Ala Ser Ile His Arg Leu Met Glu Ala Phe Ile Leu Arg Leu Gln Thr           
340                 345                 350                 355           

cag ttc ccc tcc act gtc agc act gtg tac agg aca agt gag aag ctg       1161
Gln Phe Pro Ser Thr Val Ser Thr Val Tyr Arg Thr Ser Glu Lys Leu           
                360                 365                 370               

gtg aag ggc ccc cgg gat ggc cct gct gct ggc gac tcc ggc ccc cgc       1209
Val Lys Gly Pro Arg Asp Gly Pro Ala Ala Gly Asp Ser Gly Pro Arg           
            375                 380                 385                   

tgc ctc ctc tgc atg tgt gcc ctg gac gtc gac gcc gct gac agt gcc       1257
Cys Leu Leu Cys Met Cys Ala Leu Asp Val Asp Ala Ala Asp Ser Ala           
        390                 395                 400                       

acg gct ttt ggg gct cag acc tcc tcg cgt ctc tcc cag atg cag tca       1305
Thr Ala Phe Gly Ala Gln Thr Ser Ser Arg Leu Ser Gln Met Gln Ser           
    405                 410                 415                           

ccc atc ccc ctg act gag acc cgg aca ccc ccg ggg ccc tgc tgt tct       1353
Pro Ile Pro Leu Thr Glu Thr Arg Thr Pro Pro Gly Pro Cys Cys Ser           
420                 425                 430                 435           

cca ggg gtg ggc tgg gcc cag cgc tgt ggc cag ggg gcc tgc agg agg       1401
Pro Gly Val Gly Trp Ala Gln Arg Cys Gly Gln Gly Ala Cys Arg Arg           
                440                 445                 450               

gag gac ccc caa gcc tgc att gag gag cag ctg tgc tac agc tgc cgc       1449
Glu Asp Pro Gln Ala Cys Ile Glu Glu Gln Leu Cys Tyr Ser Cys Arg           
            455                 460                 465                   

gtg aac atg aag gac ttg ccc tca ctg gac ccc ctg ccg ccg tac atc       1497
Val Asn Met Lys Asp Leu Pro Ser Leu Asp Pro Leu Pro Pro Tyr Ile           
        470                 475                 480                       

ctg gct gag gcc cag ctc cgc aca cag agg gcc tgg ggc ttg cag gag       1545
Leu Ala Glu Ala Gln Leu Arg Thr Gln Arg Ala Trp Gly Leu Gln Glu           
    485                 490                 495                           

atc cgg gac tgt ctg att gag gac agt gac gac gag gcg ggc cag agc       1593
Ile Arg Asp Cys Leu Ile Glu Asp Ser Asp Asp Glu Ala Gly Gln Ser           
500                 505                 510                 515           

tga gcgtgaggac gtgcttgccg ggacagcagg cagtggccac ctggtacacc            1646

acactggagc cggaaggcaa ggacggggga ctggcctctg attgtccatt tgtataaata     1706

aaacattttt taattaaaaa aaaaaaaaaa aaaa                                 1740


<210>  576
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  576

Met Cys Gln Val Gly Glu Asp Tyr Gly Glu Pro Ala Pro Glu Glu Pro 
1               5                   10                  15      


Pro Pro Ala Pro Arg Pro Ser Arg Glu Gln Lys Cys Val Lys Cys Lys 
            20                  25                  30          


Glu Ala Gln Pro Val Val Val Ile Arg Ala Gly Asp Ala Phe Cys Arg 
        35                  40                  45              


Asp Cys Phe Lys Ala Phe Tyr Val His Lys Phe Arg Ala Met Leu Gly 
    50                  55                  60                  


Lys Asn Arg Leu Ile Phe Pro Gly Glu Lys Val Leu Leu Ala Trp Ser 
65                  70                  75                  80  


Gly Gly Pro Ser Ser Ser Ser Met Val Trp Gln Val Leu Glu Gly Leu 
                85                  90                  95      


Ser Gln Asp Ser Ala Lys Arg Leu Arg Phe Val Ala Gly Val Ile Phe 
            100                 105                 110         


Val Asp Glu Gly Ala Ala Cys Gly Gln Ser Leu Glu Glu Arg Ser Lys 
        115                 120                 125             


Thr Leu Ala Glu Val Lys Pro Ile Leu Gln Ala Thr Gly Phe Pro Trp 
    130                 135                 140                 


His Val Val Ala Leu Glu Glu Val Phe Ser Leu Pro Pro Ser Val Leu 
145                 150                 155                 160 


Trp Cys Ser Ala Gln Glu Leu Val Gly Ser Glu Gly Ala Tyr Lys Ala 
                165                 170                 175     


Ala Val Asp Ser Phe Leu Gln Gln Gln His Val Leu Gly Ala Gly Gly 
            180                 185                 190         


Gly Pro Gly Pro Thr Gln Gly Glu Glu Gln Pro Pro Gln Pro Pro Leu 
        195                 200                 205             


Asp Pro Gln Asn Leu Ala Arg Pro Pro Ala Pro Ala Gln Thr Glu Ala 
    210                 215                 220                 


Leu Ser Gln Leu Phe Cys Ser Val Arg Thr Leu Thr Ala Lys Glu Glu 
225                 230                 235                 240 


Leu Leu Gln Thr Leu Arg Thr His Leu Ile Leu His Met Ala Arg Ala 
                245                 250                 255     


His Gly Tyr Ser Lys Val Met Thr Gly Asp Ser Cys Thr Arg Leu Ala 
            260                 265                 270         


Ile Lys Leu Met Thr Asn Leu Ala Leu Gly Arg Gly Ala Phe Leu Ala 
        275                 280                 285             


Trp Asp Thr Gly Phe Ser Asp Glu Arg His Gly Asp Val Val Val Val 
    290                 295                 300                 


Arg Pro Met Arg Asp His Thr Leu Lys Glu Val Ala Phe Tyr Asn Arg 
305                 310                 315                 320 


Leu Phe Ser Val Pro Ser Val Phe Thr Pro Ala Val Asp Thr Lys Ala 
                325                 330                 335     


Pro Glu Lys Ala Ser Ile His Arg Leu Met Glu Ala Phe Ile Leu Arg 
            340                 345                 350         


Leu Gln Thr Gln Phe Pro Ser Thr Val Ser Thr Val Tyr Arg Thr Ser 
        355                 360                 365             


Glu Lys Leu Val Lys Gly Pro Arg Asp Gly Pro Ala Ala Gly Asp Ser 
    370                 375                 380                 


Gly Pro Arg Cys Leu Leu Cys Met Cys Ala Leu Asp Val Asp Ala Ala 
385                 390                 395                 400 


Asp Ser Ala Thr Ala Phe Gly Ala Gln Thr Ser Ser Arg Leu Ser Gln 
                405                 410                 415     


Met Gln Ser Pro Ile Pro Leu Thr Glu Thr Arg Thr Pro Pro Gly Pro 
            420                 425                 430         


Cys Cys Ser Pro Gly Val Gly Trp Ala Gln Arg Cys Gly Gln Gly Ala 
        435                 440                 445             


Cys Arg Arg Glu Asp Pro Gln Ala Cys Ile Glu Glu Gln Leu Cys Tyr 
    450                 455                 460                 


Ser Cys Arg Val Asn Met Lys Asp Leu Pro Ser Leu Asp Pro Leu Pro 
465                 470                 475                 480 


Pro Tyr Ile Leu Ala Glu Ala Gln Leu Arg Thr Gln Arg Ala Trp Gly 
                485                 490                 495     


Leu Gln Glu Ile Arg Asp Cys Leu Ile Glu Asp Ser Asp Asp Glu Ala 
            500                 505                 510         


Gly Gln Ser 
        515 


<210>  577
<211>  2939
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (323)..(1609)

<400>  577
ctcgggccca cgtgagctgt agggaaacgc aggggcggct tctaggtgct gccgccgcca       60

ccgccaccac cacctccacc gccgcctcgg aacccaggcc tggggggcgg tggggccgcg      120

tatggagccc ccgccccccg gagctgccaa cattgccaac gccaccgcca cgctacacac      180

agcctcaact ttcaggagac ccgtccgtgg ccttatttat tccacccttc ctgtacatcg      240

tagcgaatca atccgtggcg ccgcactcct ccgcatccct ctttaacagt acccctggga      300

tggcgtgagc actcccccag cg atg gac cca tct gtg acg ctg tgg cag ttt       352
                         Met Asp Pro Ser Val Thr Leu Trp Gln Phe          
                         1               5                   10           

ctg ctg cag ctg ctg aga gag caa ggc aat ggc cac atc atc tcc tgg        400
Leu Leu Gln Leu Leu Arg Glu Gln Gly Asn Gly His Ile Ile Ser Trp           
                15                  20                  25                

act tca cgg gat ggt ggt gaa ttc aag ctg gtg gat gca gag gag gtg        448
Thr Ser Arg Asp Gly Gly Glu Phe Lys Leu Val Asp Ala Glu Glu Val           
            30                  35                  40                    

gcc cgg ctg tgg ggg cta cgc aag aac aag acc aac atg aat tac gac        496
Ala Arg Leu Trp Gly Leu Arg Lys Asn Lys Thr Asn Met Asn Tyr Asp           
        45                  50                  55                        

aag ctc agc cgg gcc ttg cgg tac tac tat gac aag aac atc atc cgc        544
Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Ile Arg           
    60                  65                  70                            

aag gtg agc ggc cag aag ttc gtc tac aag ttt gtg tcc tac cct gag        592
Lys Val Ser Gly Gln Lys Phe Val Tyr Lys Phe Val Ser Tyr Pro Glu           
75                  80                  85                  90            

gtc gca ggg tgc tcc act gag gac tgc ccg ccc cag cca gag gtg tct        640
Val Ala Gly Cys Ser Thr Glu Asp Cys Pro Pro Gln Pro Glu Val Ser           
                95                  100                 105               

gtt acc tcc acc atg cca aat gtg gcc cct gct gct ata cat gcc gcc        688
Val Thr Ser Thr Met Pro Asn Val Ala Pro Ala Ala Ile His Ala Ala           
            110                 115                 120                   

cca ggg gac act gtc tct gga aag cca ggc aca ccc aag ggt gca gga        736
Pro Gly Asp Thr Val Ser Gly Lys Pro Gly Thr Pro Lys Gly Ala Gly           
        125                 130                 135                       

atg gca ggc cca ggc ggt ttg gca cgc agc agc cgg aac gag tac atg        784
Met Ala Gly Pro Gly Gly Leu Ala Arg Ser Ser Arg Asn Glu Tyr Met           
    140                 145                 150                           

cgc tcg ggc ctc tat tcc acc ttc acc atc cag tct ctg cag ccg cag        832
Arg Ser Gly Leu Tyr Ser Thr Phe Thr Ile Gln Ser Leu Gln Pro Gln           
155                 160                 165                 170           

cca ccc cct cat cct cgg cct gct gtg gtg ctc ccc agt gca gct cct        880
Pro Pro Pro His Pro Arg Pro Ala Val Val Leu Pro Ser Ala Ala Pro           
                175                 180                 185               

gca ggg gca gca gcg ccc ccc tcg ggg agc agg agc acc agt cca agc        928
Ala Gly Ala Ala Ala Pro Pro Ser Gly Ser Arg Ser Thr Ser Pro Ser           
            190                 195                 200                   

ccc ttg gag gcc tgt ctg gag gct gaa gag gcc ggc ttg cct ctg cag        976
Pro Leu Glu Ala Cys Leu Glu Ala Glu Glu Ala Gly Leu Pro Leu Gln           
        205                 210                 215                       

gtc atc ctg acc ccg ccc gag gcc cca aac ctg aaa tcg gaa gag ctt       1024
Val Ile Leu Thr Pro Pro Glu Ala Pro Asn Leu Lys Ser Glu Glu Leu           
    220                 225                 230                           

aat gtg gag ccg ggt ttg ggc cgg gct ttg ccc cca gaa gtg aaa gta       1072
Asn Val Glu Pro Gly Leu Gly Arg Ala Leu Pro Pro Glu Val Lys Val           
235                 240                 245                 250           

gaa ggg ccc aag gaa gag ttg gaa gtt gcg ggg gag aga ggg ttt gtg       1120
Glu Gly Pro Lys Glu Glu Leu Glu Val Ala Gly Glu Arg Gly Phe Val           
                255                 260                 265               

cca gaa acc acc aag gcc gag cca gaa gtc cct cca cag gag ggc gtg       1168
Pro Glu Thr Thr Lys Ala Glu Pro Glu Val Pro Pro Gln Glu Gly Val           
            270                 275                 280                   

cca gcc cgg ctg ccc gcg gtt gtt atg gac acc gca ggg cag gcg ggc       1216
Pro Ala Arg Leu Pro Ala Val Val Met Asp Thr Ala Gly Gln Ala Gly           
        285                 290                 295                       

ggc cat gcg gct tcc agc cct gag atc tcc cag ccg cag aag ggc cgg       1264
Gly His Ala Ala Ser Ser Pro Glu Ile Ser Gln Pro Gln Lys Gly Arg           
    300                 305                 310                           

aag ccc cgg gac cta gag ctt cca ctc agc ccg agc ctg cta ggt ggg       1312
Lys Pro Arg Asp Leu Glu Leu Pro Leu Ser Pro Ser Leu Leu Gly Gly           
315                 320                 325                 330           

ccg gga ccc gaa cgg acc cca gga tcg gga agt ggc tcc ggc ctc cag       1360
Pro Gly Pro Glu Arg Thr Pro Gly Ser Gly Ser Gly Ser Gly Leu Gln           
                335                 340                 345               

gct ccg ggg ccg gcg ctg acc cca tcc ctg ctt cct acg cat aca ttg       1408
Ala Pro Gly Pro Ala Leu Thr Pro Ser Leu Leu Pro Thr His Thr Leu           
            350                 355                 360                   

acc ccg gtg ctg ctg aca ccc agc tcg ctg cct cct agc att cac ttc       1456
Thr Pro Val Leu Leu Thr Pro Ser Ser Leu Pro Pro Ser Ile His Phe           
        365                 370                 375                       

tgg agc acc ctg agt ccc att gcg ccc cgt agc ccg gcc aag ctc tcc       1504
Trp Ser Thr Leu Ser Pro Ile Ala Pro Arg Ser Pro Ala Lys Leu Ser           
    380                 385                 390                           

ttc cag ttt cca tcc agt ggc agc gcc cag gtg cac atc cct tct atc       1552
Phe Gln Phe Pro Ser Ser Gly Ser Ala Gln Val His Ile Pro Ser Ile           
395                 400                 405                 410           

agc gtg gat ggc ctc tcg acc ccc gtg gtg ctc tcc cca ggg ccc cag       1600
Ser Val Asp Gly Leu Ser Thr Pro Val Val Leu Ser Pro Gly Pro Gln           
                415                 420                 425               

aag cca tga ctactaccac caccaccacc accccttctg gggtcactcc               1649
Lys Pro                                                                   
                                                                          

atccatgctc tctccagcca gccatctcaa ggagaaacat agttcaactg aaagactcat     1709

gctctgattg tggtggggtg gggatccttg ggaagaatta ctcccaagag taactctcat     1769

tatctcctcc acagaaaaca cacagcttcc acaacttctc tgttttctgt cagtccccca     1829

gtggccgccc ttacacgtct cctacttcaa tggtaggggc ggtttattta tttatttttt     1889

gaaggccact gggaggagcc tgacctaacc ttttagggtg gttaggacat ctcccccacc     1949

tccccacttt tttccccaag acaagacaat cgaggtctgg cttgagaacg acctttcttt     2009

ctttatttct cagcctgccc ttggggagat gagggagccc tgtctgcgtt tttggatgtg     2069

agtagaagag ttagtttgtt ttgttttatt attcctggcc atactcaggg gtccaggaag     2129

aatttgtacc atttaatggg ttgggagtct tggccaagga agaatcacac ccttggaata     2189

gaaatttcca cctccccaac ctttctctca gacagcttat ccttttcaac caactttttg     2249

gccagggagg aatgtccctt ttgttcttcc ccctgagaag ccattccttt gtctgccaac     2309

ctccctgggg tcctgcctgt ttcctcccaa tggagggttt ttttgggggg tggtccccgt     2369

ctggggggcc cctccagcca gtactccagg tctccctgtc tctcccccgc tgccattttg     2429

atagtataat ctatttttaa atggggcttt tcaatagggg agagggagtc atctcttcct     2489

atatttggtg gggtgggtgg gaaggaaggg atttgggggg gaatcttcct gccgcctccc     2549

ccactccaag tgtttatttt tgataccaaa catgaatttt cagttccctc cctcccagcc     2609

ccccaatttc ctgcgggcgg gtacaaagga ccctttcaat gtccctggag ttgggaggga     2669

ggaatggggg acataaagcc tgtcctgtct ctattctagg caagagagag tgggttcaaa     2729

agactcctgg gctcacctgt tagcgctggc ccagcccagg ccttgggacc tgggggttgg     2789

tgatttgggg gacagtgcta cactcgtctc cactgtttgt tttacttccc caaaatggac     2849

cttttttttt tctaaagagt cccagagaat ggggaattgt tcctgtaaat atatattttt     2909

caaagtgaaa aaaaaaaaaa aaaaaaaaaa                                      2939


<210>  578
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  578

Met Asp Pro Ser Val Thr Leu Trp Gln Phe Leu Leu Gln Leu Leu Arg 
1               5                   10                  15      


Glu Gln Gly Asn Gly His Ile Ile Ser Trp Thr Ser Arg Asp Gly Gly 
            20                  25                  30          


Glu Phe Lys Leu Val Asp Ala Glu Glu Val Ala Arg Leu Trp Gly Leu 
        35                  40                  45              


Arg Lys Asn Lys Thr Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu 
    50                  55                  60                  


Arg Tyr Tyr Tyr Asp Lys Asn Ile Ile Arg Lys Val Ser Gly Gln Lys 
65                  70                  75                  80  


Phe Val Tyr Lys Phe Val Ser Tyr Pro Glu Val Ala Gly Cys Ser Thr 
                85                  90                  95      


Glu Asp Cys Pro Pro Gln Pro Glu Val Ser Val Thr Ser Thr Met Pro 
            100                 105                 110         


Asn Val Ala Pro Ala Ala Ile His Ala Ala Pro Gly Asp Thr Val Ser 
        115                 120                 125             


Gly Lys Pro Gly Thr Pro Lys Gly Ala Gly Met Ala Gly Pro Gly Gly 
    130                 135                 140                 


Leu Ala Arg Ser Ser Arg Asn Glu Tyr Met Arg Ser Gly Leu Tyr Ser 
145                 150                 155                 160 


Thr Phe Thr Ile Gln Ser Leu Gln Pro Gln Pro Pro Pro His Pro Arg 
                165                 170                 175     


Pro Ala Val Val Leu Pro Ser Ala Ala Pro Ala Gly Ala Ala Ala Pro 
            180                 185                 190         


Pro Ser Gly Ser Arg Ser Thr Ser Pro Ser Pro Leu Glu Ala Cys Leu 
        195                 200                 205             


Glu Ala Glu Glu Ala Gly Leu Pro Leu Gln Val Ile Leu Thr Pro Pro 
    210                 215                 220                 


Glu Ala Pro Asn Leu Lys Ser Glu Glu Leu Asn Val Glu Pro Gly Leu 
225                 230                 235                 240 


Gly Arg Ala Leu Pro Pro Glu Val Lys Val Glu Gly Pro Lys Glu Glu 
                245                 250                 255     


Leu Glu Val Ala Gly Glu Arg Gly Phe Val Pro Glu Thr Thr Lys Ala 
            260                 265                 270         


Glu Pro Glu Val Pro Pro Gln Glu Gly Val Pro Ala Arg Leu Pro Ala 
        275                 280                 285             


Val Val Met Asp Thr Ala Gly Gln Ala Gly Gly His Ala Ala Ser Ser 
    290                 295                 300                 


Pro Glu Ile Ser Gln Pro Gln Lys Gly Arg Lys Pro Arg Asp Leu Glu 
305                 310                 315                 320 


Leu Pro Leu Ser Pro Ser Leu Leu Gly Gly Pro Gly Pro Glu Arg Thr 
                325                 330                 335     


Pro Gly Ser Gly Ser Gly Ser Gly Leu Gln Ala Pro Gly Pro Ala Leu 
            340                 345                 350         


Thr Pro Ser Leu Leu Pro Thr His Thr Leu Thr Pro Val Leu Leu Thr 
        355                 360                 365             


Pro Ser Ser Leu Pro Pro Ser Ile His Phe Trp Ser Thr Leu Ser Pro 
    370                 375                 380                 


Ile Ala Pro Arg Ser Pro Ala Lys Leu Ser Phe Gln Phe Pro Ser Ser 
385                 390                 395                 400 


Gly Ser Ala Gln Val His Ile Pro Ser Ile Ser Val Asp Gly Leu Ser 
                405                 410                 415     


Thr Pro Val Val Leu Ser Pro Gly Pro Gln Lys Pro 
            420                 425             


<210>  579
<211>  3139
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (298)..(2271)

<400>  579
acagacagaa acgagggaag agagagaaat tggggaccct gaagaaaggg ggccagcagc       60

aggtaggtgc catcagggac aagaacagca cctcccaggg tgggagaccc caggcctttc      120

tggcagcagg tctggatgga aagtggacag gaggctcacc cgtctgcatc ccctgctcct      180

gcccctgctc ggctacaaaa accaaaggga cagcagctga ccacaccccg gtagccactc      240

ctgcataaag ctctcccctc ctgtgaccag ctgaggacct caggctgcag cggagcc         297

atg ccc aga tac acg gtg cac gta cgt ggg gaa tgg ctg gca gtg ccc        345
Met Pro Arg Tyr Thr Val His Val Arg Gly Glu Trp Leu Ala Val Pro           
1               5                   10                  15                

tgc cag gac gcg cag ctc act gtg ggc tgg ctg ggc cgg gag gcc gtg        393
Cys Gln Asp Ala Gln Leu Thr Val Gly Trp Leu Gly Arg Glu Ala Val           
            20                  25                  30                    

agg cgc tat atc aag aat aag ccc gac aat ggt ggc ttc acc tcc gtg        441
Arg Arg Tyr Ile Lys Asn Lys Pro Asp Asn Gly Gly Phe Thr Ser Val           
        35                  40                  45                        

gat gac gcg cac ttc ctt gtg cgc cgg tgc aag ggc ctg ggc ctg ctg        489
Asp Asp Ala His Phe Leu Val Arg Arg Cys Lys Gly Leu Gly Leu Leu           
    50                  55                  60                            

gac aac gag gac cgg ctc gag gtg gcc cta gag aac aac gag ttc gtg        537
Asp Asn Glu Asp Arg Leu Glu Val Ala Leu Glu Asn Asn Glu Phe Val           
65                  70                  75                  80            

gaa gtg gtt ata gag ggt gat gcc atg tct cct gac ttc att cca tct        585
Glu Val Val Ile Glu Gly Asp Ala Met Ser Pro Asp Phe Ile Pro Ser           
                85                  90                  95                

caa cca gaa gga gtt tat cta tac agc aag tac cgg gag cct gaa aag        633
Gln Pro Glu Gly Val Tyr Leu Tyr Ser Lys Tyr Arg Glu Pro Glu Lys           
            100                 105                 110                   

tac atc gag tta gat gga gac cgt ctg acc acg gag gat ctg gtc aac        681
Tyr Ile Glu Leu Asp Gly Asp Arg Leu Thr Thr Glu Asp Leu Val Asn           
        115                 120                 125                       

ttg gga aag gga cgc tac aaa ata aag ctc acc cca aca gct gag aag        729
Leu Gly Lys Gly Arg Tyr Lys Ile Lys Leu Thr Pro Thr Ala Glu Lys           
    130                 135                 140                           

agg gtg cag aaa tcc agg gag gtc ata gat agc atc ata aaa gag aaa        777
Arg Val Gln Lys Ser Arg Glu Val Ile Asp Ser Ile Ile Lys Glu Lys           
145                 150                 155                 160           

aca gtt gtt tac ggt att act aca ggt ttt ggg aaa ttt gcc aga act        825
Thr Val Val Tyr Gly Ile Thr Thr Gly Phe Gly Lys Phe Ala Arg Thr           
                165                 170                 175               

gta att cct atc aat aag cta cag gag ctt cag gtc aac tta gta cgc        873
Val Ile Pro Ile Asn Lys Leu Gln Glu Leu Gln Val Asn Leu Val Arg           
            180                 185                 190                   

tca cat tct tca ggt gtt ggg aaa cca cta agt cct gag agg tgt cgg        921
Ser His Ser Ser Gly Val Gly Lys Pro Leu Ser Pro Glu Arg Cys Arg           
        195                 200                 205                       

atg ctc ttg gct tta agg atc aat gtc tta gcc aaa gga tac agt ggc        969
Met Leu Leu Ala Leu Arg Ile Asn Val Leu Ala Lys Gly Tyr Ser Gly           
    210                 215                 220                           

att tcc ctg gag acc ctc aaa caa gtc ata gaa atg ttt aat gcc tcc       1017
Ile Ser Leu Glu Thr Leu Lys Gln Val Ile Glu Met Phe Asn Ala Ser           
225                 230                 235                 240           

tgc ctg ccc tat gtc cca gag aaa gga acc gtt ggt gcc agt gga gac       1065
Cys Leu Pro Tyr Val Pro Glu Lys Gly Thr Val Gly Ala Ser Gly Asp           
                245                 250                 255               

ctt gcc cca ctc tct cat ctt gct ctt ggg cta gtt gga gaa ggg aag       1113
Leu Ala Pro Leu Ser His Leu Ala Leu Gly Leu Val Gly Glu Gly Lys           
            260                 265                 270                   

atg tgg tct ccg aag agt ggc tgg gct gat gct aaa tac gtg cta gaa       1161
Met Trp Ser Pro Lys Ser Gly Trp Ala Asp Ala Lys Tyr Val Leu Glu           
        275                 280                 285                       

gcc cat gga ttg aaa cca gtt att tta aaa cca aaa gag ggc ctg gca       1209
Ala His Gly Leu Lys Pro Val Ile Leu Lys Pro Lys Glu Gly Leu Ala           
    290                 295                 300                           

ctc atc aat ggg acg cag atg atc aca tcc ctg ggc tgt gaa gct gta       1257
Leu Ile Asn Gly Thr Gln Met Ile Thr Ser Leu Gly Cys Glu Ala Val           
305                 310                 315                 320           

gag cga gcc agt gct att gca cgg cag gct gac att gtg gca gcc ctg       1305
Glu Arg Ala Ser Ala Ile Ala Arg Gln Ala Asp Ile Val Ala Ala Leu           
                325                 330                 335               

acc ctt gag gtg ctg aag ggc acc acc aaa gcc ttt gac act gac att       1353
Thr Leu Glu Val Leu Lys Gly Thr Thr Lys Ala Phe Asp Thr Asp Ile           
            340                 345                 350                   

cat gct ctt cga cct cac cgt ggg caa att gaa gtt gct ttt cgg ttt       1401
His Ala Leu Arg Pro His Arg Gly Gln Ile Glu Val Ala Phe Arg Phe           
        355                 360                 365                       

cgg tca ctc ttg gac tca gat cac cac cca tca gaa ata gca gag agt       1449
Arg Ser Leu Leu Asp Ser Asp His His Pro Ser Glu Ile Ala Glu Ser           
    370                 375                 380                           

cac agg ttc tgt gat cgc gtc cag gat gca tac acc ttg cgc tgc tgt       1497
His Arg Phe Cys Asp Arg Val Gln Asp Ala Tyr Thr Leu Arg Cys Cys           
385                 390                 395                 400           

cca cag gtc cat ggt gtg gtg aat gat aca ata gca ttt gtg aag aac       1545
Pro Gln Val His Gly Val Val Asn Asp Thr Ile Ala Phe Val Lys Asn           
                405                 410                 415               

atc att acc aca gaa ctg aac agc gca aca gat aat cct atg gtc ttt       1593
Ile Ile Thr Thr Glu Leu Asn Ser Ala Thr Asp Asn Pro Met Val Phe           
            420                 425                 430                   

gcc aat agg gga gag aca gtt tct gga gga aac ttc cat ggt gaa tac       1641
Ala Asn Arg Gly Glu Thr Val Ser Gly Gly Asn Phe His Gly Glu Tyr           
        435                 440                 445                       

cca gcc aaa gcc cta gac tac ttg gcc att ggc atc cat gaa ctt gct       1689
Pro Ala Lys Ala Leu Asp Tyr Leu Ala Ile Gly Ile His Glu Leu Ala           
    450                 455                 460                           

gca atc agt gag aga aga atc gag cgg ctc tgc aat ccc tcc ctc agt       1737
Ala Ile Ser Glu Arg Arg Ile Glu Arg Leu Cys Asn Pro Ser Leu Ser           
465                 470                 475                 480           

gag ctg cct gcc ttc ctg gtg gct gaa ggt ggt ctg aac tct ggg ttc       1785
Glu Leu Pro Ala Phe Leu Val Ala Glu Gly Gly Leu Asn Ser Gly Phe           
                485                 490                 495               

atg ata gct cac tgc acg gca gca gcc ctt gtt tct gag aac aag gct       1833
Met Ile Ala His Cys Thr Ala Ala Ala Leu Val Ser Glu Asn Lys Ala           
            500                 505                 510                   

ctg tgc cat ccc tcg tct gtt gac tcc ctc tcc acc agc gca gcc acg       1881
Leu Cys His Pro Ser Ser Val Asp Ser Leu Ser Thr Ser Ala Ala Thr           
        515                 520                 525                       

gag gac cac gtc tcc atg gga gga tgg gca gca agg aaa gcc ctc agg       1929
Glu Asp His Val Ser Met Gly Gly Trp Ala Ala Arg Lys Ala Leu Arg           
    530                 535                 540                           

gtc atc gag cat gtg gag caa gtg ctg gcc atc gag ctc ctt gca gcc       1977
Val Ile Glu His Val Glu Gln Val Leu Ala Ile Glu Leu Leu Ala Ala           
545                 550                 555                 560           

tgc cag ggc ata gag ttt cta cgt ccc ctg aaa aca acc act ccg ctg       2025
Cys Gln Gly Ile Glu Phe Leu Arg Pro Leu Lys Thr Thr Thr Pro Leu           
                565                 570                 575               

gag aag gtc tat gac ctg gtg cgc tct gtt gta agg ccc tgg ata aaa       2073
Glu Lys Val Tyr Asp Leu Val Arg Ser Val Val Arg Pro Trp Ile Lys           
            580                 585                 590                   

gat cgc ttc atg gcc ccg gac atc gag gca gcc cac agg ctg ctc ctg       2121
Asp Arg Phe Met Ala Pro Asp Ile Glu Ala Ala His Arg Leu Leu Leu           
        595                 600                 605                       

gag cag aag gtt tgg gaa gta gct gct cca tac att gaa aaa tac aga       2169
Glu Gln Lys Val Trp Glu Val Ala Ala Pro Tyr Ile Glu Lys Tyr Arg           
    610                 615                 620                           

atg gag cat att cca gaa tca aga cct ctt tct cca aca gcc ttt tca       2217
Met Glu His Ile Pro Glu Ser Arg Pro Leu Ser Pro Thr Ala Phe Ser           
625                 630                 635                 640           

ctg caa ttt ctg cac aag aaa tcc acc aaa atc ccg gag tct gag gac       2265
Leu Gln Phe Leu His Lys Lys Ser Thr Lys Ile Pro Glu Ser Glu Asp           
                645                 650                 655               

ctt taa tgggctttgt catgaagtag cagatgagag ggcagtcagt ttagcacaaa        2321
Leu                                                                       
                                                                          

gcaatactag gctgaaggag agacctgaga actttcctag gtagatcaat ccattgtatc     2381

attcagttct tctaaagcct acgttggtta ggctgatggc agtattatag ttgctaaatt     2441

cagcactgtg ttcctgttgt cgtggttcaa gacccaccag gtattttcag attataaaac     2501

ttttctttct ttcttaacag tttcaacagg ccactcactc ttaagggtga gaagaataac     2561

cacaattgta tgtgcctgtt ttttactctt agcattagat gaattcaaat ttggaaacag     2621

attgatagca attttttcta aaaacattag acttttgtta accttttttt ttttttttaa     2681

atttgcttca acaagctctc caccagttga ctttctttgg ctaattttac tttgcatgat     2741

atgccttaat atgccttcat aaataaccat tttaagtcat aatttgtcct taagctgctt     2801

ttttcttcta ttaattggat catagtaaag agtagtcaat agggtcttca gctattaatt     2861

gtagaggtga ttaaaaccaa caaggagttt catgtgcaaa ggagataagg aatgaatata     2921

aagattgcta tttgggtggc tcttattaaa ctgtgtattt tgtacttatc actacacgta     2981

tcccccaaat gcttacatgg gagtttgagg ttagtatttt cacttccttg gtgttagtac     3041

tctattcaca ttcttattgt aaccttcctc atttcacaga taaggaatct ttggggatta     3101

accaacctcc tttctgtaat ggtaatcatt aaaataag                             3139


<210>  580
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  580

Met Pro Arg Tyr Thr Val His Val Arg Gly Glu Trp Leu Ala Val Pro 
1               5                   10                  15      


Cys Gln Asp Ala Gln Leu Thr Val Gly Trp Leu Gly Arg Glu Ala Val 
            20                  25                  30          


Arg Arg Tyr Ile Lys Asn Lys Pro Asp Asn Gly Gly Phe Thr Ser Val 
        35                  40                  45              


Asp Asp Ala His Phe Leu Val Arg Arg Cys Lys Gly Leu Gly Leu Leu 
    50                  55                  60                  


Asp Asn Glu Asp Arg Leu Glu Val Ala Leu Glu Asn Asn Glu Phe Val 
65                  70                  75                  80  


Glu Val Val Ile Glu Gly Asp Ala Met Ser Pro Asp Phe Ile Pro Ser 
                85                  90                  95      


Gln Pro Glu Gly Val Tyr Leu Tyr Ser Lys Tyr Arg Glu Pro Glu Lys 
            100                 105                 110         


Tyr Ile Glu Leu Asp Gly Asp Arg Leu Thr Thr Glu Asp Leu Val Asn 
        115                 120                 125             


Leu Gly Lys Gly Arg Tyr Lys Ile Lys Leu Thr Pro Thr Ala Glu Lys 
    130                 135                 140                 


Arg Val Gln Lys Ser Arg Glu Val Ile Asp Ser Ile Ile Lys Glu Lys 
145                 150                 155                 160 


Thr Val Val Tyr Gly Ile Thr Thr Gly Phe Gly Lys Phe Ala Arg Thr 
                165                 170                 175     


Val Ile Pro Ile Asn Lys Leu Gln Glu Leu Gln Val Asn Leu Val Arg 
            180                 185                 190         


Ser His Ser Ser Gly Val Gly Lys Pro Leu Ser Pro Glu Arg Cys Arg 
        195                 200                 205             


Met Leu Leu Ala Leu Arg Ile Asn Val Leu Ala Lys Gly Tyr Ser Gly 
    210                 215                 220                 


Ile Ser Leu Glu Thr Leu Lys Gln Val Ile Glu Met Phe Asn Ala Ser 
225                 230                 235                 240 


Cys Leu Pro Tyr Val Pro Glu Lys Gly Thr Val Gly Ala Ser Gly Asp 
                245                 250                 255     


Leu Ala Pro Leu Ser His Leu Ala Leu Gly Leu Val Gly Glu Gly Lys 
            260                 265                 270         


Met Trp Ser Pro Lys Ser Gly Trp Ala Asp Ala Lys Tyr Val Leu Glu 
        275                 280                 285             


Ala His Gly Leu Lys Pro Val Ile Leu Lys Pro Lys Glu Gly Leu Ala 
    290                 295                 300                 


Leu Ile Asn Gly Thr Gln Met Ile Thr Ser Leu Gly Cys Glu Ala Val 
305                 310                 315                 320 


Glu Arg Ala Ser Ala Ile Ala Arg Gln Ala Asp Ile Val Ala Ala Leu 
                325                 330                 335     


Thr Leu Glu Val Leu Lys Gly Thr Thr Lys Ala Phe Asp Thr Asp Ile 
            340                 345                 350         


His Ala Leu Arg Pro His Arg Gly Gln Ile Glu Val Ala Phe Arg Phe 
        355                 360                 365             


Arg Ser Leu Leu Asp Ser Asp His His Pro Ser Glu Ile Ala Glu Ser 
    370                 375                 380                 


His Arg Phe Cys Asp Arg Val Gln Asp Ala Tyr Thr Leu Arg Cys Cys 
385                 390                 395                 400 


Pro Gln Val His Gly Val Val Asn Asp Thr Ile Ala Phe Val Lys Asn 
                405                 410                 415     


Ile Ile Thr Thr Glu Leu Asn Ser Ala Thr Asp Asn Pro Met Val Phe 
            420                 425                 430         


Ala Asn Arg Gly Glu Thr Val Ser Gly Gly Asn Phe His Gly Glu Tyr 
        435                 440                 445             


Pro Ala Lys Ala Leu Asp Tyr Leu Ala Ile Gly Ile His Glu Leu Ala 
    450                 455                 460                 


Ala Ile Ser Glu Arg Arg Ile Glu Arg Leu Cys Asn Pro Ser Leu Ser 
465                 470                 475                 480 


Glu Leu Pro Ala Phe Leu Val Ala Glu Gly Gly Leu Asn Ser Gly Phe 
                485                 490                 495     


Met Ile Ala His Cys Thr Ala Ala Ala Leu Val Ser Glu Asn Lys Ala 
            500                 505                 510         


Leu Cys His Pro Ser Ser Val Asp Ser Leu Ser Thr Ser Ala Ala Thr 
        515                 520                 525             


Glu Asp His Val Ser Met Gly Gly Trp Ala Ala Arg Lys Ala Leu Arg 
    530                 535                 540                 


Val Ile Glu His Val Glu Gln Val Leu Ala Ile Glu Leu Leu Ala Ala 
545                 550                 555                 560 


Cys Gln Gly Ile Glu Phe Leu Arg Pro Leu Lys Thr Thr Thr Pro Leu 
                565                 570                 575     


Glu Lys Val Tyr Asp Leu Val Arg Ser Val Val Arg Pro Trp Ile Lys 
            580                 585                 590         


Asp Arg Phe Met Ala Pro Asp Ile Glu Ala Ala His Arg Leu Leu Leu 
        595                 600                 605             


Glu Gln Lys Val Trp Glu Val Ala Ala Pro Tyr Ile Glu Lys Tyr Arg 
    610                 615                 620                 


Met Glu His Ile Pro Glu Ser Arg Pro Leu Ser Pro Thr Ala Phe Ser 
625                 630                 635                 640 


Leu Gln Phe Leu His Lys Lys Ser Thr Lys Ile Pro Glu Ser Glu Asp 
                645                 650                 655     


Leu 
    


<210>  581
<211>  4225
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (438)..(2843)

<400>  581
gcagagggtg cggcccagag gaggccgcgg gccgggaagg gccgggcggg acgggaaacg       60

ttagggcagc ggcccccggg gtgagggggc cgagcggacg ggcagggccc cgaggcgaac      120

tctgcccgga tgaggaacaa agcagtgggg caggcgcgtg cgcccccagc gcagctggca      180

ggttgggcag cccccttccc gaagcttctg gacggaaggc cccaggtgtt ccccgagatg      240

ccccaacccg tggcggggtg cacggccacc ggccctcggg agaagttggg cggccccggg      300

cgaccccggg gacgagtggc cgcgtcggtg cagcggttgt gagcaagatg tggtagcacg      360

tgaccctgga acgcaaaccc tgatgcctgt tccccaccac ccgagcgctc ctttctctga      420

tatttggccc caagccg atg cat cac agg atg aat gaa atg aac ctg agt         470
                   Met His His Arg Met Asn Glu Met Asn Leu Ser            
                   1               5                   10                 

cca gtg ggg atg gag cag ctg act tca tcc tct gtg agc aat gcc ttg        518
Pro Val Gly Met Glu Gln Leu Thr Ser Ser Ser Val Ser Asn Ala Leu           
            15                  20                  25                    

cca gtc tca gga agt cac ctg gga ttg gct gcc tca ccc act cac agt        566
Pro Val Ser Gly Ser His Leu Gly Leu Ala Ala Ser Pro Thr His Ser           
        30                  35                  40                        

gcc atc cct gcc cca ggc ctc cca gtg gca att cca aac ctg ggt ccc        614
Ala Ile Pro Ala Pro Gly Leu Pro Val Ala Ile Pro Asn Leu Gly Pro           
    45                  50                  55                            

tcc ctg agc tct ctg cct tct gct ctg tct tta atg cta cca atg ggt        662
Ser Leu Ser Ser Leu Pro Ser Ala Leu Ser Leu Met Leu Pro Met Gly           
60                  65                  70                  75            

att ggg gat cga ggg gtg atg tgt ggg tta cct gaa aga aac tac acc        710
Ile Gly Asp Arg Gly Val Met Cys Gly Leu Pro Glu Arg Asn Tyr Thr           
                80                  85                  90                

cta cct cca cca cct tac cct cac ctg gag agc agt tat ttc aga acc        758
Leu Pro Pro Pro Pro Tyr Pro His Leu Glu Ser Ser Tyr Phe Arg Thr           
            95                  100                 105                   

att cta cct ggc att tta tct tat tta gct gac aga cca cct cca cag        806
Ile Leu Pro Gly Ile Leu Ser Tyr Leu Ala Asp Arg Pro Pro Pro Gln           
        110                 115                 120                       

tac atc cac cct aac tct ata aat gtt gat ggt aat aca gca tta tct        854
Tyr Ile His Pro Asn Ser Ile Asn Val Asp Gly Asn Thr Ala Leu Ser           
    125                 130                 135                           

atc acc aat aac cct tca gca cta gat ccc tat cag tcc aat gga aat        902
Ile Thr Asn Asn Pro Ser Ala Leu Asp Pro Tyr Gln Ser Asn Gly Asn           
140                 145                 150                 155           

gtt gga tta gaa cca ggc att gtt tca ata gac tct cgc tct gtg aac        950
Val Gly Leu Glu Pro Gly Ile Val Ser Ile Asp Ser Arg Ser Val Asn           
                160                 165                 170               

aca cat ggt gcc caa agt ctt cat ccc agt gat ggc cat gag gtg gcc        998
Thr His Gly Ala Gln Ser Leu His Pro Ser Asp Gly His Glu Val Ala           
            175                 180                 185                   

ttg gac aca gca atc act atg gag aac gtt tct agg gtt acc agc cca       1046
Leu Asp Thr Ala Ile Thr Met Glu Asn Val Ser Arg Val Thr Ser Pro           
        190                 195                 200                       

att tcg aca gat gga atg gca gag gag ctt acg atg gac ggt gtt gca       1094
Ile Ser Thr Asp Gly Met Ala Glu Glu Leu Thr Met Asp Gly Val Ala           
    205                 210                 215                           

ggc gag cat tcc caa atc cca aat ggc tcc aga agt cat gaa cct ctg       1142
Gly Glu His Ser Gln Ile Pro Asn Gly Ser Arg Ser His Glu Pro Leu           
220                 225                 230                 235           

tct gtg gat tct gtg agc aac aac ctt gca gca gac gct gta gga cat       1190
Ser Val Asp Ser Val Ser Asn Asn Leu Ala Ala Asp Ala Val Gly His           
                240                 245                 250               

ggt ggt gtg ata ccc atg cat ggg aat ggc ctg gag ctc cct gtg gtc       1238
Gly Gly Val Ile Pro Met His Gly Asn Gly Leu Glu Leu Pro Val Val           
            255                 260                 265                   

atg gag aca gac cac att gca agt cgg gtc aat ggc atg tct gac agt       1286
Met Glu Thr Asp His Ile Ala Ser Arg Val Asn Gly Met Ser Asp Ser           
        270                 275                 280                       

gcc ctc agt gac tcc att cac act gtg gcc atg agc acc aac tct gta       1334
Ala Leu Ser Asp Ser Ile His Thr Val Ala Met Ser Thr Asn Ser Val           
    285                 290                 295                           

agc gtg gca ctc tct acc tca cac aac ctt gcc tcc cta gaa tct gtt       1382
Ser Val Ala Leu Ser Thr Ser His Asn Leu Ala Ser Leu Glu Ser Val           
300                 305                 310                 315           

tcc ctc cat gaa gtt ggc ctc agc cta gaa cct gtg gct gtc tcc tcc       1430
Ser Leu His Glu Val Gly Leu Ser Leu Glu Pro Val Ala Val Ser Ser           
                320                 325                 330               

atc acc cag gag gtt gct atg ggg aca ggt cat gta gat gta tct tca       1478
Ile Thr Gln Glu Val Ala Met Gly Thr Gly His Val Asp Val Ser Ser           
            335                 340                 345                   

gac agt ctt tct ttt gta tca cct tca ctg caa atg gaa gac tcc aat       1526
Asp Ser Leu Ser Phe Val Ser Pro Ser Leu Gln Met Glu Asp Ser Asn           
        350                 355                 360                       

tca aac aag gag aac atg gca acc ttg ttt aca att tgg tgt act ctg       1574
Ser Asn Lys Glu Asn Met Ala Thr Leu Phe Thr Ile Trp Cys Thr Leu           
    365                 370                 375                           

tgt gac cgc gcc tat ccc tcg gac tgt ccc gaa cat gga cca gtg act       1622
Cys Asp Arg Ala Tyr Pro Ser Asp Cys Pro Glu His Gly Pro Val Thr           
380                 385                 390                 395           

ttt gtt cct gac act cca ata gag agc aga gca agg ctt tct ctc cca       1670
Phe Val Pro Asp Thr Pro Ile Glu Ser Arg Ala Arg Leu Ser Leu Pro           
                400                 405                 410               

aag cag ctt gtt ctc cgt cag tca att gtg gga gca gaa gtt ggt gta       1718
Lys Gln Leu Val Leu Arg Gln Ser Ile Val Gly Ala Glu Val Gly Val           
            415                 420                 425                   

tgg act gga gaa acc att cct gtg cgg act tgc ttt gga cct cta att       1766
Trp Thr Gly Glu Thr Ile Pro Val Arg Thr Cys Phe Gly Pro Leu Ile           
        430                 435                 440                       

ggc cag cag agt cac tcc atg gaa gta gca gaa tgg aca gac aag gca       1814
Gly Gln Gln Ser His Ser Met Glu Val Ala Glu Trp Thr Asp Lys Ala           
    445                 450                 455                           

gtt aac cat atc tgg aag ata tac cac aat ggt gtc cta gaa ttc tgc       1862
Val Asn His Ile Trp Lys Ile Tyr His Asn Gly Val Leu Glu Phe Cys           
460                 465                 470                 475           

atc att aca act gat gaa aat gaa tgt aat tgg atg atg ttt gtg cgc       1910
Ile Ile Thr Thr Asp Glu Asn Glu Cys Asn Trp Met Met Phe Val Arg           
                480                 485                 490               

aaa gcc agg aac cgg gaa gag cag aat ttg gtg gct tat cct cat gat       1958
Lys Ala Arg Asn Arg Glu Glu Gln Asn Leu Val Ala Tyr Pro His Asp           
            495                 500                 505                   

gga aaa atc ttt ttc tgc acc tca caa gat atc cct cct gaa aat gaa       2006
Gly Lys Ile Phe Phe Cys Thr Ser Gln Asp Ile Pro Pro Glu Asn Glu           
        510                 515                 520                       

ctg ctt ttt tat tat agc cga gat tat gct caa cag att ggt gtt cct       2054
Leu Leu Phe Tyr Tyr Ser Arg Asp Tyr Ala Gln Gln Ile Gly Val Pro           
    525                 530                 535                           

gaa cac cca gat gtg cat ctc tgt aac tgt ggc aag gag tgc aat tct       2102
Glu His Pro Asp Val His Leu Cys Asn Cys Gly Lys Glu Cys Asn Ser           
540                 545                 550                 555           

tac aca gag ttc aaa gcc cat ctg acc agc cac atc cat aac cat ctt       2150
Tyr Thr Glu Phe Lys Ala His Leu Thr Ser His Ile His Asn His Leu           
                560                 565                 570               

cct acc cag gga cat agc ggc agc cat ggg cca agt cac agc aaa gaa       2198
Pro Thr Gln Gly His Ser Gly Ser His Gly Pro Ser His Ser Lys Glu           
            575                 580                 585                   

agg aag tgg aag tgc tca atg tgc ccc caa gct ttt atc tct cct tcc       2246
Arg Lys Trp Lys Cys Ser Met Cys Pro Gln Ala Phe Ile Ser Pro Ser           
        590                 595                 600                       

aaa ctt cat gtc cac ttt atg ggt cac atg ggt atg aag ccc cac aag       2294
Lys Leu His Val His Phe Met Gly His Met Gly Met Lys Pro His Lys           
    605                 610                 615                           

tgt gat ttc tgt agc aag gct ttt agt gat ccc agc aac ctg cgg acc       2342
Cys Asp Phe Cys Ser Lys Ala Phe Ser Asp Pro Ser Asn Leu Arg Thr           
620                 625                 630                 635           

cac ctc aag ata cat aca ggt cag aag aac tac agg tgt acc ttg tgt       2390
His Leu Lys Ile His Thr Gly Gln Lys Asn Tyr Arg Cys Thr Leu Cys           
                640                 645                 650               

gac aag tct ttc acc cag aag gct cac ctg gag tcc cac atg gtt atc       2438
Asp Lys Ser Phe Thr Gln Lys Ala His Leu Glu Ser His Met Val Ile           
            655                 660                 665                   

cac act ggg gag aag aat ctt aag tgt gat tac tgt gac aag ttg ttt       2486
His Thr Gly Glu Lys Asn Leu Lys Cys Asp Tyr Cys Asp Lys Leu Phe           
        670                 675                 680                       

atg cgg agg cag gac ctc aag cag cac gtg ctc atc cac act caa gaa       2534
Met Arg Arg Gln Asp Leu Lys Gln His Val Leu Ile His Thr Gln Glu           
    685                 690                 695                           

cgc cag atc aag tgt ccc aag tgt gat aag ctg ttc ttg aga aca aat       2582
Arg Gln Ile Lys Cys Pro Lys Cys Asp Lys Leu Phe Leu Arg Thr Asn           
700                 705                 710                 715           

cac tta aag aag cat ctc aat tct cat gaa gga aaa cgg gat tat gtc       2630
His Leu Lys Lys His Leu Asn Ser His Glu Gly Lys Arg Asp Tyr Val           
                720                 725                 730               

tgt gaa aaa tgt aca aag gct tat cta acc aaa tac cat ctc acc cgc       2678
Cys Glu Lys Cys Thr Lys Ala Tyr Leu Thr Lys Tyr His Leu Thr Arg           
            735                 740                 745                   

cac ctg aaa acc tgc aaa ggg ccc acc tcc agt tcg tca gca cca gag       2726
His Leu Lys Thr Cys Lys Gly Pro Thr Ser Ser Ser Ser Ala Pro Glu           
        750                 755                 760                       

gag gaa gaa gag gat gac tca gaa gag gaa gat cta gca gac tct gtg       2774
Glu Glu Glu Glu Asp Asp Ser Glu Glu Glu Asp Leu Ala Asp Ser Val           
    765                 770                 775                           

ggg aca gaa gac tgt agg att aac agt gct gtg tat tca gcg gat gag       2822
Gly Thr Glu Asp Cys Arg Ile Asn Ser Ala Val Tyr Ser Ala Asp Glu           
780                 785                 790                 795           

tct ctt tct gca cat aaa taa aaggaaaaga aacaagcaat tttggatgaa          2873
Ser Leu Ser Ala His Lys                                                   
                800                                                       

aatgcaaatg gaaaaataca cataaccagt tatctactat aatggttttt atataaaatg     2933

gttcctgatt tattttcagc cagtaatcaa aacagactgg gaatgaataa agcacttaca     2993

gaagagtatc ctaatgaaaa cactttaaaa cagattggga aaactgagca tgtgtcctgt     3053

tttaagtggt ggactgggag ggaagtgtca acttctgagg tctttattta catgataatc     3113

tgggagatgc atttatgcct gaatcaaagc tgccttctgc tcaaacaaat cagatttatt     3173

tcacattctt ccattattcc attttcctgc tggtcctgtg acttggtaac attctaaacg     3233

gtccttgccc catagccatc ctgattgctg atagtgtttt atgcagactc ttgtgactta     3293

tactcaccac agaatggatt gggacacagc agcataagtg tgctacttgg cagctagtaa     3353

gtttaaagca ggacctgcct taactgctcc tggccacttg gaagtttagg gtagatcttg     3413

ttttccaaag tttcggcagg tgcctggagg gcaaataaaa aagcagcagt cagtcagtag     3473

tcagtgatgg agagaacaag aggagagatg cctggcctct gcccaagaaa ttagctttga     3533

tggaagcctg agcaagtcac ctggttattg taacgtggag atctttgtag gtttagacat     3593

ggctccctgt ctccagtaaa catccagcca ttcagacaaa gggggcctgg agatacagag     3653

agcccaaata atgcctgctg gattgtctcc tgatgagtac atgtggactc acctgaggaa     3713

gggaaggaag ggaataatct tttatgtttc atttacctta tgaaaagtgt taaaacattg     3773

ccaactcaaa ataacattat ttaatgcatg tgcaaagtta ggtcttccca gttgtctcag     3833

tgctgaggaa cctcatcaga gaagcatgga agatgccaaa ggatttttgg aaggtaaaga     3893

aggctgaata gtgaccacat gggcctgttt tcagggtccc agcttagtta agtcacccat     3953

gcacctggtc attgtgtctc ccatgcacat ccagcgtttc tcagaagcag acccaccctt     4013

aagttgacag gattgatgga acatgctctc ctgctcaagg cacaacctct gggctggagt     4073

agaggactct ggtgggaagg ttttgctgct aatgtattta tggaatgaat gtatttcatt     4133

caaatctgta ttcctctagg aaggattaaa attaaacttt tttaaaatac aggaaaaaaa     4193

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                   4225


<210>  582
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  582

Met His His Arg Met Asn Glu Met Asn Leu Ser Pro Val Gly Met Glu 
1               5                   10                  15      


Gln Leu Thr Ser Ser Ser Val Ser Asn Ala Leu Pro Val Ser Gly Ser 
            20                  25                  30          


His Leu Gly Leu Ala Ala Ser Pro Thr His Ser Ala Ile Pro Ala Pro 
        35                  40                  45              


Gly Leu Pro Val Ala Ile Pro Asn Leu Gly Pro Ser Leu Ser Ser Leu 
    50                  55                  60                  


Pro Ser Ala Leu Ser Leu Met Leu Pro Met Gly Ile Gly Asp Arg Gly 
65                  70                  75                  80  


Val Met Cys Gly Leu Pro Glu Arg Asn Tyr Thr Leu Pro Pro Pro Pro 
                85                  90                  95      


Tyr Pro His Leu Glu Ser Ser Tyr Phe Arg Thr Ile Leu Pro Gly Ile 
            100                 105                 110         


Leu Ser Tyr Leu Ala Asp Arg Pro Pro Pro Gln Tyr Ile His Pro Asn 
        115                 120                 125             


Ser Ile Asn Val Asp Gly Asn Thr Ala Leu Ser Ile Thr Asn Asn Pro 
    130                 135                 140                 


Ser Ala Leu Asp Pro Tyr Gln Ser Asn Gly Asn Val Gly Leu Glu Pro 
145                 150                 155                 160 


Gly Ile Val Ser Ile Asp Ser Arg Ser Val Asn Thr His Gly Ala Gln 
                165                 170                 175     


Ser Leu His Pro Ser Asp Gly His Glu Val Ala Leu Asp Thr Ala Ile 
            180                 185                 190         


Thr Met Glu Asn Val Ser Arg Val Thr Ser Pro Ile Ser Thr Asp Gly 
        195                 200                 205             


Met Ala Glu Glu Leu Thr Met Asp Gly Val Ala Gly Glu His Ser Gln 
    210                 215                 220                 


Ile Pro Asn Gly Ser Arg Ser His Glu Pro Leu Ser Val Asp Ser Val 
225                 230                 235                 240 


Ser Asn Asn Leu Ala Ala Asp Ala Val Gly His Gly Gly Val Ile Pro 
                245                 250                 255     


Met His Gly Asn Gly Leu Glu Leu Pro Val Val Met Glu Thr Asp His 
            260                 265                 270         


Ile Ala Ser Arg Val Asn Gly Met Ser Asp Ser Ala Leu Ser Asp Ser 
        275                 280                 285             


Ile His Thr Val Ala Met Ser Thr Asn Ser Val Ser Val Ala Leu Ser 
    290                 295                 300                 


Thr Ser His Asn Leu Ala Ser Leu Glu Ser Val Ser Leu His Glu Val 
305                 310                 315                 320 


Gly Leu Ser Leu Glu Pro Val Ala Val Ser Ser Ile Thr Gln Glu Val 
                325                 330                 335     


Ala Met Gly Thr Gly His Val Asp Val Ser Ser Asp Ser Leu Ser Phe 
            340                 345                 350         


Val Ser Pro Ser Leu Gln Met Glu Asp Ser Asn Ser Asn Lys Glu Asn 
        355                 360                 365             


Met Ala Thr Leu Phe Thr Ile Trp Cys Thr Leu Cys Asp Arg Ala Tyr 
    370                 375                 380                 


Pro Ser Asp Cys Pro Glu His Gly Pro Val Thr Phe Val Pro Asp Thr 
385                 390                 395                 400 


Pro Ile Glu Ser Arg Ala Arg Leu Ser Leu Pro Lys Gln Leu Val Leu 
                405                 410                 415     


Arg Gln Ser Ile Val Gly Ala Glu Val Gly Val Trp Thr Gly Glu Thr 
            420                 425                 430         


Ile Pro Val Arg Thr Cys Phe Gly Pro Leu Ile Gly Gln Gln Ser His 
        435                 440                 445             


Ser Met Glu Val Ala Glu Trp Thr Asp Lys Ala Val Asn His Ile Trp 
    450                 455                 460                 


Lys Ile Tyr His Asn Gly Val Leu Glu Phe Cys Ile Ile Thr Thr Asp 
465                 470                 475                 480 


Glu Asn Glu Cys Asn Trp Met Met Phe Val Arg Lys Ala Arg Asn Arg 
                485                 490                 495     


Glu Glu Gln Asn Leu Val Ala Tyr Pro His Asp Gly Lys Ile Phe Phe 
            500                 505                 510         


Cys Thr Ser Gln Asp Ile Pro Pro Glu Asn Glu Leu Leu Phe Tyr Tyr 
        515                 520                 525             


Ser Arg Asp Tyr Ala Gln Gln Ile Gly Val Pro Glu His Pro Asp Val 
    530                 535                 540                 


His Leu Cys Asn Cys Gly Lys Glu Cys Asn Ser Tyr Thr Glu Phe Lys 
545                 550                 555                 560 


Ala His Leu Thr Ser His Ile His Asn His Leu Pro Thr Gln Gly His 
                565                 570                 575     


Ser Gly Ser His Gly Pro Ser His Ser Lys Glu Arg Lys Trp Lys Cys 
            580                 585                 590         


Ser Met Cys Pro Gln Ala Phe Ile Ser Pro Ser Lys Leu His Val His 
        595                 600                 605             


Phe Met Gly His Met Gly Met Lys Pro His Lys Cys Asp Phe Cys Ser 
    610                 615                 620                 


Lys Ala Phe Ser Asp Pro Ser Asn Leu Arg Thr His Leu Lys Ile His 
625                 630                 635                 640 


Thr Gly Gln Lys Asn Tyr Arg Cys Thr Leu Cys Asp Lys Ser Phe Thr 
                645                 650                 655     


Gln Lys Ala His Leu Glu Ser His Met Val Ile His Thr Gly Glu Lys 
            660                 665                 670         


Asn Leu Lys Cys Asp Tyr Cys Asp Lys Leu Phe Met Arg Arg Gln Asp 
        675                 680                 685             


Leu Lys Gln His Val Leu Ile His Thr Gln Glu Arg Gln Ile Lys Cys 
    690                 695                 700                 


Pro Lys Cys Asp Lys Leu Phe Leu Arg Thr Asn His Leu Lys Lys His 
705                 710                 715                 720 


Leu Asn Ser His Glu Gly Lys Arg Asp Tyr Val Cys Glu Lys Cys Thr 
                725                 730                 735     


Lys Ala Tyr Leu Thr Lys Tyr His Leu Thr Arg His Leu Lys Thr Cys 
            740                 745                 750         


Lys Gly Pro Thr Ser Ser Ser Ser Ala Pro Glu Glu Glu Glu Glu Asp 
        755                 760                 765             


Asp Ser Glu Glu Glu Asp Leu Ala Asp Ser Val Gly Thr Glu Asp Cys 
    770                 775                 780                 


Arg Ile Asn Ser Ala Val Tyr Ser Ala Asp Glu Ser Leu Ser Ala His 
785                 790                 795                 800 


Lys 
    


<210>  583
<211>  1376
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (422)..(880)

<400>  583
ggcagtggga ctgggtttga gctgggctta tcctccaact gtgagggagg ctacagcaca       60

ctccacccca ctctcagggc tgggaattgt tgtggctcag ctatttgggg gaatctgttt      120

tccagtttct cagaaccagc gcaagcacac acatcccagg ctcacacccc tggtggctgg      180

acttgctccc ggatagcctc agtcagggag aggcagagct gcctggagcc tgctgggctg      240

gtggaagcct tggtggattc tggcaggcca attatagacg aatggcctgg ggaacccgtg      300

cagcccttgg ctgagtggtt ctaagcccca gcacgtctgc ctctggcttc acccagcctc      360

cttttctaac tgcccttctc tcctccccat cagtgaggac cagacaccac tgattgcagg      420

a atg tgt tcc ctc ccc atg gca aga tac tac ata att aaa tat gca gac      469
  Met Cys Ser Leu Pro Met Ala Arg Tyr Tyr Ile Ile Lys Tyr Ala Asp         
  1               5                   10                  15              

cag aag gct cta tac aca aga gat ggc cag ctg ctg gtg gga gat cct        517
Gln Lys Ala Leu Tyr Thr Arg Asp Gly Gln Leu Leu Val Gly Asp Pro           
            20                  25                  30                    

gtt gca gac aac tgc tgt gca gag aag atc tgc ata ctt cct aac aga        565
Val Ala Asp Asn Cys Cys Ala Glu Lys Ile Cys Ile Leu Pro Asn Arg           
        35                  40                  45                        

ggc ttg gcc cgc acc aag gtc ccc att ttc ctg ggg atc cag gga ggg        613
Gly Leu Ala Arg Thr Lys Val Pro Ile Phe Leu Gly Ile Gln Gly Gly           
    50                  55                  60                            

agc cgc tgc ctg gca tgt gtg gag aca gaa gag ggg cct tcc cta cag        661
Ser Arg Cys Leu Ala Cys Val Glu Thr Glu Glu Gly Pro Ser Leu Gln           
65                  70                  75                  80            

ctg gag gat gtg aac att gag gaa ctg tac aaa ggt ggt gaa gag gcc        709
Leu Glu Asp Val Asn Ile Glu Glu Leu Tyr Lys Gly Gly Glu Glu Ala           
                85                  90                  95                

aca cgc ttc acc ttc ttc cag agc agc tca ggc tcc gcc ttc agg ctt        757
Thr Arg Phe Thr Phe Phe Gln Ser Ser Ser Gly Ser Ala Phe Arg Leu           
            100                 105                 110                   

gag gct gct gcc tgg cct ggc tgg ttc ctg tgt ggc ccg gca gag ccc        805
Glu Ala Ala Ala Trp Pro Gly Trp Phe Leu Cys Gly Pro Ala Glu Pro           
        115                 120                 125                       

cag cag cca gta cag ctc acc aag gag agt gag ccc tca gcc cgt acc        853
Gln Gln Pro Val Gln Leu Thr Lys Glu Ser Glu Pro Ser Ala Arg Thr           
    130                 135                 140                           

aag ttt tac ttt gaa cag agc tgg tag ggagacagga aactgcgttt              900
Lys Phe Tyr Phe Glu Gln Ser Trp                                           
145                 150                                                   

tagccttgtg cccccaaacc aagctcatcc tgctcagggt ctatggtagg cagaataatg      960

tcccccgaaa tatgtccaca tcctaatccc aagatctgtg catatgttac catacatgtc     1020

caaagaggtt ttgcaaatgt gattatgtta aggatcttga aatgaggaga caatcctggg     1080

ttatccttgt gggctcagtt taatcacaag aaggaggcag gaagggagag tcagagagag     1140

aatggaagat accatgcttc taattttgaa gatggagtga ggggccttga gccaacaaat     1200

gcaggtgttt ttagaaggtg gaaaagccaa gggaacggat tctcctctag agtctccgga     1260

aggaacacag ctcttgacac atggatttca gctcagtgac acccatttca gacttctgac     1320

ctccacaact ataaaataat aaacttgtgt tattgtaaac ctctaaaaaa aaaaaa         1376


<210>  584
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  584

Met Cys Ser Leu Pro Met Ala Arg Tyr Tyr Ile Ile Lys Tyr Ala Asp 
1               5                   10                  15      


Gln Lys Ala Leu Tyr Thr Arg Asp Gly Gln Leu Leu Val Gly Asp Pro 
            20                  25                  30          


Val Ala Asp Asn Cys Cys Ala Glu Lys Ile Cys Ile Leu Pro Asn Arg 
        35                  40                  45              


Gly Leu Ala Arg Thr Lys Val Pro Ile Phe Leu Gly Ile Gln Gly Gly 
    50                  55                  60                  


Ser Arg Cys Leu Ala Cys Val Glu Thr Glu Glu Gly Pro Ser Leu Gln 
65                  70                  75                  80  


Leu Glu Asp Val Asn Ile Glu Glu Leu Tyr Lys Gly Gly Glu Glu Ala 
                85                  90                  95      


Thr Arg Phe Thr Phe Phe Gln Ser Ser Ser Gly Ser Ala Phe Arg Leu 
            100                 105                 110         


Glu Ala Ala Ala Trp Pro Gly Trp Phe Leu Cys Gly Pro Ala Glu Pro 
        115                 120                 125             


Gln Gln Pro Val Gln Leu Thr Lys Glu Ser Glu Pro Ser Ala Arg Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Glu Gln Ser Trp 
145                 150         


<210>  585
<211>  6683
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (259)..(1551)

<400>  585
cttccccacc agcccttatc cccaccctca ccccgcaacc ccttcacgcc ccctccccct       60

ccccctcctc atcctcccac catcctctaa agaggcaaag ggattttttt tttcttttgg      120

tcttcttttt tcccccttcc ctgtttatcc tgaaaaggat ttgaagacaa gcttgaagga      180

taaaaagcct tggtgcttcc caggagccga gccgaggagc agaagaggaa gagccggggg      240

ctgccgtagc ctttggag atg gac gag cag ccc agg ctg atg cat tcc cat        291
                    Met Asp Glu Gln Pro Arg Leu Met His Ser His           
                    1               5                   10                

gct ggg gtc ggg atg gcc gga cac ccc ggc ctg tcc cag cac ttg cag        339
Ala Gly Val Gly Met Ala Gly His Pro Gly Leu Ser Gln His Leu Gln           
            15                  20                  25                    

gat ggg gcc gga ggg acc gag ggg gag ggc ggg agg aag cag gac att        387
Asp Gly Ala Gly Gly Thr Glu Gly Glu Gly Gly Arg Lys Gln Asp Ile           
        30                  35                  40                        

gga gac att tta cag caa att atg acc atc aca gac cag agt ttg gat        435
Gly Asp Ile Leu Gln Gln Ile Met Thr Ile Thr Asp Gln Ser Leu Asp           
    45                  50                  55                            

gag gcg cag gcc aga aaa cat gct tta aac tgc cac aga atg aag cct        483
Glu Ala Gln Ala Arg Lys His Ala Leu Asn Cys His Arg Met Lys Pro           
60                  65                  70                  75            

gcc ttg ttt aat gtg ttg tgt gaa atc aaa gaa aaa aca gtt ttg agt        531
Ala Leu Phe Asn Val Leu Cys Glu Ile Lys Glu Lys Thr Val Leu Ser           
                80                  85                  90                

atc cga gga gcc cag gag gag gaa ccc aca gac ccc cag ctg atg cgg        579
Ile Arg Gly Ala Gln Glu Glu Glu Pro Thr Asp Pro Gln Leu Met Arg           
            95                  100                 105                   

ctg gac aac atg ctg tta gcg gaa ggc gtg gcg ggg cct gag aag ggc        627
Leu Asp Asn Met Leu Leu Ala Glu Gly Val Ala Gly Pro Glu Lys Gly           
        110                 115                 120                       

gga ggg tcg gcg gca gcg gcg gca gcg gcg gcg gct tct gga ggg gca        675
Gly Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Gly Ala           
    125                 130                 135                           

ggt tca gac aac tca gtg gag cat tca gat tac aga gcc aaa ctc tca        723
Gly Ser Asp Asn Ser Val Glu His Ser Asp Tyr Arg Ala Lys Leu Ser           
140                 145                 150                 155           

cag atc aga caa atc tac cat acg gag ctg gag aaa tac gag cag gcc        771
Gln Ile Arg Gln Ile Tyr His Thr Glu Leu Glu Lys Tyr Glu Gln Ala           
                160                 165                 170               

tgc aac gag ttc acc acc cac gtg atg aat ctc ctg cga gag caa agc        819
Cys Asn Glu Phe Thr Thr His Val Met Asn Leu Leu Arg Glu Gln Ser           
            175                 180                 185                   

cgg acc agg ccc atc tcc cca aag gag att gag cgg atg gtc agc atc        867
Arg Thr Arg Pro Ile Ser Pro Lys Glu Ile Glu Arg Met Val Ser Ile           
        190                 195                 200                       

atc cac cgc aag ttc agc tcc atc cag atg cag ctc aag cag agc acg        915
Ile His Arg Lys Phe Ser Ser Ile Gln Met Gln Leu Lys Gln Ser Thr           
    205                 210                 215                           

tgc gag gcg gtg atg atc ctg cgt tcc cga ttt ctg gat gcg cgg cgg        963
Cys Glu Ala Val Met Ile Leu Arg Ser Arg Phe Leu Asp Ala Arg Arg           
220                 225                 230                 235           

aag aga cgg aat ttc aac aag caa gcg aca gaa atc ctg aat gaa tat       1011
Lys Arg Arg Asn Phe Asn Lys Gln Ala Thr Glu Ile Leu Asn Glu Tyr           
                240                 245                 250               

ttc tat tcc cat ctc agc aac cct tac ccc agt gag gaa gcc aaa gag       1059
Phe Tyr Ser His Leu Ser Asn Pro Tyr Pro Ser Glu Glu Ala Lys Glu           
            255                 260                 265                   

gag tta gcc aag aag tgt ggc atc aca gtc tcc cag gta tca aac tgg       1107
Glu Leu Ala Lys Lys Cys Gly Ile Thr Val Ser Gln Val Ser Asn Trp           
        270                 275                 280                       

ttt gga aat aag cga atc cgg tac aag aag aac ata ggt aaa ttt caa       1155
Phe Gly Asn Lys Arg Ile Arg Tyr Lys Lys Asn Ile Gly Lys Phe Gln           
    285                 290                 295                           

gag gaa gcc aat att tat gct gcc aaa aca gct gtc act gct acc aat       1203
Glu Glu Ala Asn Ile Tyr Ala Ala Lys Thr Ala Val Thr Ala Thr Asn           
300                 305                 310                 315           

gtg tca gcc cat gga agc caa gct aac tcg ccc tca act ccc aac tcg       1251
Val Ser Ala His Gly Ser Gln Ala Asn Ser Pro Ser Thr Pro Asn Ser           
                320                 325                 330               

gct ggt tct tcc agt tct ttt aac atg tca aac tct gga gat ttg ttc       1299
Ala Gly Ser Ser Ser Ser Phe Asn Met Ser Asn Ser Gly Asp Leu Phe           
            335                 340                 345                   

atg agc gtg cag tca ctc aat ggg gat tct tac caa ggg gcc cag gtt       1347
Met Ser Val Gln Ser Leu Asn Gly Asp Ser Tyr Gln Gly Ala Gln Val           
        350                 355                 360                       

gga gcc aac gtg caa tca cag gtg gat acc ctt cgc cat gtt atc agc       1395
Gly Ala Asn Val Gln Ser Gln Val Asp Thr Leu Arg His Val Ile Ser           
    365                 370                 375                           

cag aca gga gga tac agt gat gga ctc gca gcc agt cag atg tac agt       1443
Gln Thr Gly Gly Tyr Ser Asp Gly Leu Ala Ala Ser Gln Met Tyr Ser           
380                 385                 390                 395           

ccg cag ggc atc agt gct aat gga ggt tgg cag gat gct act acc cct       1491
Pro Gln Gly Ile Ser Ala Asn Gly Gly Trp Gln Asp Ala Thr Thr Pro           
                400                 405                 410               

tca tca gtg acc tcc cct aca gaa ggc cct ggc agt gtt cac tct gat       1539
Ser Ser Val Thr Ser Pro Thr Glu Gly Pro Gly Ser Val His Ser Asp           
            415                 420                 425                   

acc tcc aac tga tctcccagca atcgcatccc ggctgaccct gtgccccagt           1591
Thr Ser Asn                                                               
        430                                                               

tggggcaggg gcaggaggga gggtttctct cccaacgctg aagcggtcag actggaggtc     1651

gaagcaatca gcaaacacaa taagagtctc cttctcttct cttctttggg atgctatttc     1711

agccaatctg gacacttctt tatactctct tccctttttt ttctgggtag aagccaccct     1771

tccctgcctc cagctgtcag cctggttttc gtcatcttcc ctgcccctgt gcctctgtcc     1831

tagactcccg gggtccccgc cctctctcat atcactgaag gatattttca acaattagag     1891

gaatttaaag aggaaaaaaa ttacaaagaa aataataaaa gtgtttgtac gttttcatgc     1951

tggtggtttg aggagccaaa tttacctcac tcgaatccct cactccctat gttaacaggc     2011

aatccttctc tgtttctctt attactctca ctacctctta gcaggaatac tccacattgc     2071

cctattcatt ccaggcctcc ctgcttcctc ttgctcttcc tccctgggga cagtactgat     2131

tggaacactt tcctcctctt ccttcctagc cccagctatt cactggggac tgtcatagct     2191

gggattctaa aggtgccaca tttttcagtt tcatctccac taggttggtt cccgggcagg     2251

aagtcaggca gcagggaagg acacgggaac agcaggtgga gaattcctac agtctttctt     2311

accctgctag caatagctct cagtttcaga ggcacagtct ttggagacca ttcagcactg     2371

agaaagcaat atttagaacc tattgcaaaa ctgggcctga gttaggcatg gtgatgaatg     2431

catcagcaag gaatagaaag ttcttatcgt gaaacccttc aacctcaact atgccttcat     2491

agacacacac gttcatgcac atgtaggcac atgtaccatc tcacatcttc actttcccga     2551

gatgccatat acaattacct acattaataa ctgtagcact atgccttttg agcccgagag     2611

agggaattag tgactctaag tgaaggtcac tgacacagag aagcagtatg tgtctggggc     2671

ttccaggacc tgcaggccca ctagcgtgca cttaccagaa tggcatacac aggacctgat     2731

catgaggaag accaggtttc cagtgtaaac tactcttgtt cccaccacct ctggagcact     2791

cagggagccc catacagtac ttacaatgtc tttaatggac ttgattctgt ttaatttttt     2851

gttttatatt aggcacactg tattaatttt ccaaaatgtt ataccacact atgttcttgg     2911

tcctgaccta ttgctctgga ggaaagagtt gtataagaac gtggctcatg tgaacttttg     2971

ctagcttcat ttgaggacct gagaatcatg gggaaaggga aggtaatgtt ttcattgaaa     3031

tcatcacagt gatttttatt ccctgggaac acagcgtgta ctaaaaatac atgagaaaat     3091

agcatgtata tgaaagctat tctcaaaagt cacctgagct caccatcttc atagccaacc     3151

ctaccagtta taaagatggc agctctatca cttgattaag tgggaggtgg tcaaatattt     3211

tggtgcctca ttttcttcat ctgtgagatg ggaactgtta tgcctggctt actaagagtc     3271

ttgtgagaga ctgagaagtt gattttgttc atatccaatc tgtaaatgcg aagtcagggg     3331

aagtaatgtc cctgaaataa acgggttcat gccatctagg gacaataaat ggttttcttg     3391

ttgtaacttc tggttaatat cagtaccttg atgtcatcac cgtgatgaca aagagaagag     3451

ttattgttga tcttcttggt tttggtctgt ctcttttctt aggataaaga aaaacttcca     3511

aactagaaaa acaggccctg gttcccttag tttgcacttg aacccaatat gttgccttgt     3571

acatacttgg tccctgtcac attgactgct tgggaggctt ccagggagaa gtatgagacc     3631

ctgaggggtg agaatgggca gctagcaaga acatggaaat tctgcttggc actacagtca     3691

taaatagaaa acactgtgtg tgctcagggg agcaggggat gccactgaag aaactcaagg     3751

gaatgtgtat ttgaaggaaa tgcaaaaact aagtatttag caaaatgaaa ttatgccttg     3811

atgactaaaa ggcactagaa aggttgtgtc tactaacttc agccctaatc agaacagatg     3871

cctagaagga gcatttttgt gacaacttca tagtgattag aatcagtgga gaactccatc     3931

ttagtggcag gaatataatg aaactaccca cgcaagaaca tggttgaatc acatttgctt     3991

gacttagggc aaagtacgaa agagagacaa aagggttctc ttggaaacaa gaagagtgac     4051

tccagatgtg gcctgaataa ttgccatgtt aagttaatgc aaaagatcag aacagggcta     4111

catttgcaca ggcagtttct ctccgggccg tagttttcac tgatgatcac ctttcacagc     4171

attttcccca accagcattt cacttagtct tctctatacc cagcacctcc cccggcaccc     4231

ccggcaagcc cactatcact tccgacttcc aacgtggcat ccgtgagatc tgtccacatt     4291

aggcgaagca ggagaacact gagagcagca ggatgggttt ggaaagagca tgcctctgga     4351

aacacagctt cctgggaatt cacatgaggc cagtcctaca gagagcaaga tgcaccccag     4411

gatttcttca ttttctaata gatgtgggag tgctccattt tccccgacag cgaatttccc     4471

ctgagaaacg atactagacc ctgggtttgc ccaccttgta actcttcctt atctcctcct     4531

tttcatccct aatccatcct ccctctggca tggaattgac gcccgtgcag tacatttgcc     4591

aagtggcacc ttctttcaat ttatgtttta ttttgctatg gtggtgattc tttatttgct     4651

ggttgtcttt tctcacacat ctttctctct gtctctctct ttcctgctct ttgtttttct     4711

gcccagaaaa acctgacttc gataccaaaa aagatgaaac tacagaaact caaatttaaa     4771

aaaaacttta aaagaaacaa aaaaatactc aacgattctt tcagctttat taacattttc     4831

cattgtttct tgcgacttgt gtctcgttct ttgtagtatt gatgatgaac atttgataat     4891

gaatgttctt gtatattcag ataaagaaaa aaaaaaccaa aaaagcggtc tgaatttaat     4951

agtgtttata ataaaaattt taaaaatgac cctcatagca cgcaaaacag gatggggaat     5011

ttcccctctt ctttctgtga caatgcgcat cattcctgca ttagttttta acaccagact     5071

acctacattc atcatttccc tcatttttct tttattttct tgcatttgtg aattagttca     5131

agaatgctag aaaagtgtcg agttgtgcac atccatttct tgtttcacaa tgtttaaaag     5191

tgacagtaat tcattttgta aactaaaaaa aaaaaaaaaa aggttggaat agtgagcata     5251

ataggtacaa cctaacacat tattatgttt attaactttg agacccagaa ataaattctt     5311

ttcttttctt gattcttgct cttaaaaata caaaaaaaaa aatgttttgt tttgtgttat     5371

ttttggtttg tttattgggg ggcttttttt aattgtcagg attatgatct tgctgttttt     5431

cttcaatatg tatacaaggt gatgtgaaaa gatgacttgg gcagaggagt aagaacaagt     5491

aggcttgttc ttctactttg cttcagaatt cagttaatgc caaaagcgaa gatcaagccc     5551

atgttgatgt ctcgttgctc acctgcattt ccagagagtg tgacactcat gcagtccctg     5611

agaaaaataa aatcagggac atacttctcc ttttagcctt ttaaaaattc aaaaacgttt     5671

agtccaaggg aactttttat gctatcagga aaggtttttg ctgtttttga ttctgattat     5731

cacagccaag tactttgttt tatttctccc taattaataa ctacattcca tgaggcctct     5791

tccaaccaaa gaggcctttt cttccaggag agtcccgcag gagatgctgg tatgatgggc     5851

accattggtt aagtaaacta catgcaggaa gaagtccttg gggccagtct gccagctgag     5911

tcctggtttt ggatgaagag ttaatgagat attgggccag gctcaatgct gtagttttaa     5971

tgctaagagg ttacgtttac ttcacagagt acacctctta gtaacctctg acttaggcag     6031

ctgcttaaag caaattgcaa aactggcttg atttggaatg tttttattag aggaaaaaag     6091

aaagccatat tatctggaaa aaaattcatt ttaaatacca tcattcaaca aattatgttc     6151

agaaagtggt cagaacttaa gcaagaaaag taaagaaaga atgcagaatt gtggagcaat     6211

gctttaggaa atatttctac ctgaacactt gtactcttga agtcacaaca aaataatgat     6271

gagcttttca catcaccttt atggtttcaa tccctagctc aaagcttcct ggaatctttt     6331

attttttgta aacttttttt tcttttgtta aaataaataa aacattcaat gtttttctcc     6391

ttttctctct tattacttct ttcctttggc attttcaatt tgaaatgctt tcctttggtt     6451

gttggtttta ttctccccct acccctcccc ttttcttatt attcagaata taaacctgca     6511

aagctctgct ctgttttggt tttgaaagtt taagcttttc tgcttctgtg agagcacagg     6571

cttctgtccc ttttgattcc aactgaactt ttgtgttctc taatgatact aacacggtgt     6631

aggttttaca gtctcctaat ttgtactggt aatgcatatt ccaaataaat ag             6683


<210>  586
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  586

Met Asp Glu Gln Pro Arg Leu Met His Ser His Ala Gly Val Gly Met 
1               5                   10                  15      


Ala Gly His Pro Gly Leu Ser Gln His Leu Gln Asp Gly Ala Gly Gly 
            20                  25                  30          


Thr Glu Gly Glu Gly Gly Arg Lys Gln Asp Ile Gly Asp Ile Leu Gln 
        35                  40                  45              


Gln Ile Met Thr Ile Thr Asp Gln Ser Leu Asp Glu Ala Gln Ala Arg 
    50                  55                  60                  


Lys His Ala Leu Asn Cys His Arg Met Lys Pro Ala Leu Phe Asn Val 
65                  70                  75                  80  


Leu Cys Glu Ile Lys Glu Lys Thr Val Leu Ser Ile Arg Gly Ala Gln 
                85                  90                  95      


Glu Glu Glu Pro Thr Asp Pro Gln Leu Met Arg Leu Asp Asn Met Leu 
            100                 105                 110         


Leu Ala Glu Gly Val Ala Gly Pro Glu Lys Gly Gly Gly Ser Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Ala Ala Ser Gly Gly Ala Gly Ser Asp Asn Ser 
    130                 135                 140                 


Val Glu His Ser Asp Tyr Arg Ala Lys Leu Ser Gln Ile Arg Gln Ile 
145                 150                 155                 160 


Tyr His Thr Glu Leu Glu Lys Tyr Glu Gln Ala Cys Asn Glu Phe Thr 
                165                 170                 175     


Thr His Val Met Asn Leu Leu Arg Glu Gln Ser Arg Thr Arg Pro Ile 
            180                 185                 190         


Ser Pro Lys Glu Ile Glu Arg Met Val Ser Ile Ile His Arg Lys Phe 
        195                 200                 205             


Ser Ser Ile Gln Met Gln Leu Lys Gln Ser Thr Cys Glu Ala Val Met 
    210                 215                 220                 


Ile Leu Arg Ser Arg Phe Leu Asp Ala Arg Arg Lys Arg Arg Asn Phe 
225                 230                 235                 240 


Asn Lys Gln Ala Thr Glu Ile Leu Asn Glu Tyr Phe Tyr Ser His Leu 
                245                 250                 255     


Ser Asn Pro Tyr Pro Ser Glu Glu Ala Lys Glu Glu Leu Ala Lys Lys 
            260                 265                 270         


Cys Gly Ile Thr Val Ser Gln Val Ser Asn Trp Phe Gly Asn Lys Arg 
        275                 280                 285             


Ile Arg Tyr Lys Lys Asn Ile Gly Lys Phe Gln Glu Glu Ala Asn Ile 
    290                 295                 300                 


Tyr Ala Ala Lys Thr Ala Val Thr Ala Thr Asn Val Ser Ala His Gly 
305                 310                 315                 320 


Ser Gln Ala Asn Ser Pro Ser Thr Pro Asn Ser Ala Gly Ser Ser Ser 
                325                 330                 335     


Ser Phe Asn Met Ser Asn Ser Gly Asp Leu Phe Met Ser Val Gln Ser 
            340                 345                 350         


Leu Asn Gly Asp Ser Tyr Gln Gly Ala Gln Val Gly Ala Asn Val Gln 
        355                 360                 365             


Ser Gln Val Asp Thr Leu Arg His Val Ile Ser Gln Thr Gly Gly Tyr 
    370                 375                 380                 


Ser Asp Gly Leu Ala Ala Ser Gln Met Tyr Ser Pro Gln Gly Ile Ser 
385                 390                 395                 400 


Ala Asn Gly Gly Trp Gln Asp Ala Thr Thr Pro Ser Ser Val Thr Ser 
                405                 410                 415     


Pro Thr Glu Gly Pro Gly Ser Val His Ser Asp Thr Ser Asn 
            420                 425                 430 


<210>  587
<211>  3070
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (284)..(2629)

<400>  587
actcccggaa gcagattgcg ccagggaaag gccttatcgc tgtgtgtgtg tttcagtcta       60

cgtggattaa acattacttc gctccgtctg cctggattaa acgtgcactt tgcagtcctc      120

acttctccgt accagtgatc tggggatcgc tacggacctt aaaataccca tagccccttc      180

gcccctgcaa caggcacttc tccccacgtt tgatgtgtga ataattacat tgactgagaa      240

agaaacccag aagaggaaga agaggaagga aaaggagtca gtg atg gct act cag        295
                                                Met Ala Thr Gln           
                                                1                         

ggg cat ttg aca ttc aag gat gta gcc ata gaa ttc tct cag gag gag        343
Gly His Leu Thr Phe Lys Asp Val Ala Ile Glu Phe Ser Gln Glu Glu           
5                   10                  15                  20            

tgg aaa tgc ctg gag cct gtg cag aaa gct ttg tac aag gat gtg atg        391
Trp Lys Cys Leu Glu Pro Val Gln Lys Ala Leu Tyr Lys Asp Val Met           
                25                  30                  35                

ttg gag aac tat agg aac ctg gtc ttc cta ggt atc tct cct aaa tgt        439
Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Gly Ile Ser Pro Lys Cys           
            40                  45                  50                    

gtg atc aag gaa tta cca cca aca gag aac agt aat aca gga gaa agg        487
Val Ile Lys Glu Leu Pro Pro Thr Glu Asn Ser Asn Thr Gly Glu Arg           
        55                  60                  65                        

ttc caa aca gtg gca ctg gaa aga cat caa agc tat gat att gaa aat        535
Phe Gln Thr Val Ala Leu Glu Arg His Gln Ser Tyr Asp Ile Glu Asn           
    70                  75                  80                            

tta tac ttc agg gaa ata cag aaa cat cta cat gac ctt gaa ttt caa        583
Leu Tyr Phe Arg Glu Ile Gln Lys His Leu His Asp Leu Glu Phe Gln           
85                  90                  95                  100           

tgg aaa gat ggt gaa aca aat gat aaa gaa gtg cca gtg ccc cat gaa        631
Trp Lys Asp Gly Glu Thr Asn Asp Lys Glu Val Pro Val Pro His Glu           
                105                 110                 115               

aac aat ctt act ggt aaa aga gat caa cat agt caa ggg gat gta gaa        679
Asn Asn Leu Thr Gly Lys Arg Asp Gln His Ser Gln Gly Asp Val Glu           
            120                 125                 130                   

aac aat cat att gaa aac cag ctt aca tca aac ttt gag tca cgt ctg        727
Asn Asn His Ile Glu Asn Gln Leu Thr Ser Asn Phe Glu Ser Arg Leu           
        135                 140                 145                       

gct gaa ctg cag aaa gtt caa act gaa ggg aga ctt tat gaa tgt aat        775
Ala Glu Leu Gln Lys Val Gln Thr Glu Gly Arg Leu Tyr Glu Cys Asn           
    150                 155                 160                           

gaa acg gag aag aca ggt aat aat ggt tgt tta gtt tct cca cac att        823
Glu Thr Glu Lys Thr Gly Asn Asn Gly Cys Leu Val Ser Pro His Ile           
165                 170                 175                 180           

agg gaa aaa acg tat gta tgt aat gaa tgt ggc aaa gcc ttt aaa gcg        871
Arg Glu Lys Thr Tyr Val Cys Asn Glu Cys Gly Lys Ala Phe Lys Ala           
                185                 190                 195               

tct tcc agc ctt att aat cat cag agg ata cat act aca gag aaa cct        919
Ser Ser Ser Leu Ile Asn His Gln Arg Ile His Thr Thr Glu Lys Pro           
            200                 205                 210                   

tac aaa tgc aat gag tgt ggc aaa gcc ttt cat cgg gcc tca cta cta        967
Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe His Arg Ala Ser Leu Leu           
        215                 220                 225                       

act gta cac aag gta gtc cat aca aga ggg aaa tca tat caa tgt gat       1015
Thr Val His Lys Val Val His Thr Arg Gly Lys Ser Tyr Gln Cys Asp           
    230                 235                 240                           

gta tgt ggc aag atc ttc aga aaa aat tca tat ttt gta aga cac caa       1063
Val Cys Gly Lys Ile Phe Arg Lys Asn Ser Tyr Phe Val Arg His Gln           
245                 250                 255                 260           

agg agt cac act gga cag aaa ccc tac ata tgt aat gaa tgt ggc aag       1111
Arg Ser His Thr Gly Gln Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys           
                265                 270                 275               

tcc ttt agt aaa agt tcc cac ctt gca gtt cat cag aga att cat acc       1159
Ser Phe Ser Lys Ser Ser His Leu Ala Val His Gln Arg Ile His Thr           
            280                 285                 290                   

ggt gaa aaa cct tac aaa tgt aat ctg tgt ggg aaa tcc ttt agt cag       1207
Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Gly Lys Ser Phe Ser Gln           
        295                 300                 305                       

cgt gtc cat ctt aga ctt cat cag aca gtt cat act gga gag aga ccc       1255
Arg Val His Leu Arg Leu His Gln Thr Val His Thr Gly Glu Arg Pro           
    310                 315                 320                           

ttc aaa tgt aat gag tgt ggc aaa acc ttt aaa cgg agc tca aac ctc       1303
Phe Lys Cys Asn Glu Cys Gly Lys Thr Phe Lys Arg Ser Ser Asn Leu           
325                 330                 335                 340           

act gta cat cag gta atc cat gca gga aag aaa cca tat aaa tgt gat       1351
Thr Val His Gln Val Ile His Ala Gly Lys Lys Pro Tyr Lys Cys Asp           
                345                 350                 355               

gta tgt ggc aag gca ttc aga cat aga tca aat ctt gta tgt cac cgg       1399
Val Cys Gly Lys Ala Phe Arg His Arg Ser Asn Leu Val Cys His Arg           
            360                 365                 370                   

aga atc cac agt gga gag aaa caa tac aaa tgc aat gaa tgt ggc aag       1447
Arg Ile His Ser Gly Glu Lys Gln Tyr Lys Cys Asn Glu Cys Gly Lys           
        375                 380                 385                       

gtc ttc agt aaa cgt tca agt ctt gca gtg cat cga cga att cac act       1495
Val Phe Ser Lys Arg Ser Ser Leu Ala Val His Arg Arg Ile His Thr           
    390                 395                 400                           

gta gag aaa cct tgc aaa tgc aat gaa tgt ggc aag gtc ttc agt aaa       1543
Val Glu Lys Pro Cys Lys Cys Asn Glu Cys Gly Lys Val Phe Ser Lys           
405                 410                 415                 420           

cgt tca agt ctt gca gtg cat cag aga att cat act gga cag aaa act       1591
Arg Ser Ser Leu Ala Val His Gln Arg Ile His Thr Gly Gln Lys Thr           
                425                 430                 435               

tac aaa tgc aat aaa tgt ggc aag gtg tac agt aag cat tca cat ctt       1639
Tyr Lys Cys Asn Lys Cys Gly Lys Val Tyr Ser Lys His Ser His Leu           
            440                 445                 450                   

gca gtg cat tgg aga att cat acc ggc gag aaa gct tat aaa tgc aat       1687
Ala Val His Trp Arg Ile His Thr Gly Glu Lys Ala Tyr Lys Cys Asn           
        455                 460                 465                       

gaa tgt ggc aaa gtt ttc agc ata cat tca cga ctt gca gct cat cag       1735
Glu Cys Gly Lys Val Phe Ser Ile His Ser Arg Leu Ala Ala His Gln           
    470                 475                 480                           

aga att cat act gga gag aaa cct tac aaa tgc aat gaa tgt ggc aag       1783
Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys           
485                 490                 495                 500           

gtc ttc agt caa cat tca cgt ctt gca gtg cat cgg aga att cat act       1831
Val Phe Ser Gln His Ser Arg Leu Ala Val His Arg Arg Ile His Thr           
                505                 510                 515               

gga gag aaa cct tac aaa tgc aaa gaa tgt ggc aag gtc ttc agt gac       1879
Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Val Phe Ser Asp           
            520                 525                 530                   

cgt tca gct ttt gca agg cat cgg aga att cat act gga gag aag cct       1927
Arg Ser Ala Phe Ala Arg His Arg Arg Ile His Thr Gly Glu Lys Pro           
        535                 540                 545                       

tac aaa tgc aaa gaa tgt ggc aag gtc ttc agt caa tgt tca cgt ctt       1975
Tyr Lys Cys Lys Glu Cys Gly Lys Val Phe Ser Gln Cys Ser Arg Leu           
    550                 555                 560                           

aca gtg cat cgg aga att cat agt gga gag aaa cct tac aaa tgc aat       2023
Thr Val His Arg Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Asn           
565                 570                 575                 580           

gaa tgc ggc aag gtc tac agt cag tat tca cat ctt gta ggg cat cga       2071
Glu Cys Gly Lys Val Tyr Ser Gln Tyr Ser His Leu Val Gly His Arg           
                585                 590                 595               

aga gtt cat act gga gag aaa cca tac aaa tgt cat gaa tgt ggc aaa       2119
Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys His Glu Cys Gly Lys           
            600                 605                 610                   

gcc ttt aat cag ggc tcc aca ctc aat aga cat cag aga att cat acc       2167
Ala Phe Asn Gln Gly Ser Thr Leu Asn Arg His Gln Arg Ile His Thr           
        615                 620                 625                       

gga gag aaa cct tac aaa tgc aat cag tgt ggg aat tcc ttt agt cag       2215
Gly Glu Lys Pro Tyr Lys Cys Asn Gln Cys Gly Asn Ser Phe Ser Gln           
    630                 635                 640                           

cgt gtc cat ctt aga ctt cat cag act gtt cat act gga gac aga cct       2263
Arg Val His Leu Arg Leu His Gln Thr Val His Thr Gly Asp Arg Pro           
645                 650                 655                 660           

tac aaa tgt aat gag tgt ggc aaa acc ttt aaa cgg agc tca aac ctc       2311
Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe Lys Arg Ser Ser Asn Leu           
                665                 670                 675               

act gca cat cag ata att cat gca gga aag aaa cca tat aaa tgt gat       2359
Thr Ala His Gln Ile Ile His Ala Gly Lys Lys Pro Tyr Lys Cys Asp           
            680                 685                 690                   

gaa tgt ggc aag gta ttc agg cat agt tca cat ctt gta agt cac cag       2407
Glu Cys Gly Lys Val Phe Arg His Ser Ser His Leu Val Ser His Gln           
        695                 700                 705                       

aga atc cac act gga gag aaa aga tac aaa tgt att gaa tgt ggc aaa       2455
Arg Ile His Thr Gly Glu Lys Arg Tyr Lys Cys Ile Glu Cys Gly Lys           
    710                 715                 720                           

gcc ttt ggg cgg ttg ttt tcc ctc agc aaa cac caa aga att cat tct       2503
Ala Phe Gly Arg Leu Phe Ser Leu Ser Lys His Gln Arg Ile His Ser           
725                 730                 735                 740           

ggc aaa aaa cct tat aaa tgt aat gag tgt ggg aaa tct ttt att tgt       2551
Gly Lys Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ser Phe Ile Cys           
                745                 750                 755               

cgc tca ggc ctc act aaa cat cga ata aga cat act gga gag agc ctt       2599
Arg Ser Gly Leu Thr Lys His Arg Ile Arg His Thr Gly Glu Ser Leu           
            760                 765                 770                   

aca act aaa ctc aat gtg aca agg cct tag acgttgtcct agtttctgga         2649
Thr Thr Lys Leu Asn Val Thr Arg Pro                                       
        775                 780                                           

atcaccgaat aattcctact tactgatata ccttgtatat ttaccccttc tcttgaaatc     2709

cctgtggaat tgtaatctcc agtattggag gtggggccca ttgggaggtg attgaatcat     2769

ggaagtggat ttctcaaact gagaaagatg tagcgtcatc cccttggtgc tgtcctggca     2829

atagtgactt ctcttgaggt ctggctgttt agaagtgcat agcacttccc tgtcgcttgc     2889

cctcattctc accatgtgaa ataccgacac ccgctttgcc ttccaccatg attttaacct     2949

tcctgaggct tccctagagg gtgatcagat gccagcacca tgttttcatt taagccttca     3009

gaaatatgag ccaattaaac tcttttcttt atacattaaa aaaaaaaaaa aaaaaaaaaa     3069

a                                                                     3070


<210>  588
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  588

Met Ala Thr Gln Gly His Leu Thr Phe Lys Asp Val Ala Ile Glu Phe 
1               5                   10                  15      


Ser Gln Glu Glu Trp Lys Cys Leu Glu Pro Val Gln Lys Ala Leu Tyr 
            20                  25                  30          


Lys Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Val Phe Leu Gly Ile 
        35                  40                  45              


Ser Pro Lys Cys Val Ile Lys Glu Leu Pro Pro Thr Glu Asn Ser Asn 
    50                  55                  60                  


Thr Gly Glu Arg Phe Gln Thr Val Ala Leu Glu Arg His Gln Ser Tyr 
65                  70                  75                  80  


Asp Ile Glu Asn Leu Tyr Phe Arg Glu Ile Gln Lys His Leu His Asp 
                85                  90                  95      


Leu Glu Phe Gln Trp Lys Asp Gly Glu Thr Asn Asp Lys Glu Val Pro 
            100                 105                 110         


Val Pro His Glu Asn Asn Leu Thr Gly Lys Arg Asp Gln His Ser Gln 
        115                 120                 125             


Gly Asp Val Glu Asn Asn His Ile Glu Asn Gln Leu Thr Ser Asn Phe 
    130                 135                 140                 


Glu Ser Arg Leu Ala Glu Leu Gln Lys Val Gln Thr Glu Gly Arg Leu 
145                 150                 155                 160 


Tyr Glu Cys Asn Glu Thr Glu Lys Thr Gly Asn Asn Gly Cys Leu Val 
                165                 170                 175     


Ser Pro His Ile Arg Glu Lys Thr Tyr Val Cys Asn Glu Cys Gly Lys 
            180                 185                 190         


Ala Phe Lys Ala Ser Ser Ser Leu Ile Asn His Gln Arg Ile His Thr 
        195                 200                 205             


Thr Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe His Arg 
    210                 215                 220                 


Ala Ser Leu Leu Thr Val His Lys Val Val His Thr Arg Gly Lys Ser 
225                 230                 235                 240 


Tyr Gln Cys Asp Val Cys Gly Lys Ile Phe Arg Lys Asn Ser Tyr Phe 
                245                 250                 255     


Val Arg His Gln Arg Ser His Thr Gly Gln Lys Pro Tyr Ile Cys Asn 
            260                 265                 270         


Glu Cys Gly Lys Ser Phe Ser Lys Ser Ser His Leu Ala Val His Gln 
        275                 280                 285             


Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Gly Lys 
    290                 295                 300                 


Ser Phe Ser Gln Arg Val His Leu Arg Leu His Gln Thr Val His Thr 
305                 310                 315                 320 


Gly Glu Arg Pro Phe Lys Cys Asn Glu Cys Gly Lys Thr Phe Lys Arg 
                325                 330                 335     


Ser Ser Asn Leu Thr Val His Gln Val Ile His Ala Gly Lys Lys Pro 
            340                 345                 350         


Tyr Lys Cys Asp Val Cys Gly Lys Ala Phe Arg His Arg Ser Asn Leu 
        355                 360                 365             


Val Cys His Arg Arg Ile His Ser Gly Glu Lys Gln Tyr Lys Cys Asn 
    370                 375                 380                 


Glu Cys Gly Lys Val Phe Ser Lys Arg Ser Ser Leu Ala Val His Arg 
385                 390                 395                 400 


Arg Ile His Thr Val Glu Lys Pro Cys Lys Cys Asn Glu Cys Gly Lys 
                405                 410                 415     


Val Phe Ser Lys Arg Ser Ser Leu Ala Val His Gln Arg Ile His Thr 
            420                 425                 430         


Gly Gln Lys Thr Tyr Lys Cys Asn Lys Cys Gly Lys Val Tyr Ser Lys 
        435                 440                 445             


His Ser His Leu Ala Val His Trp Arg Ile His Thr Gly Glu Lys Ala 
    450                 455                 460                 


Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Ser Ile His Ser Arg Leu 
465                 470                 475                 480 


Ala Ala His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn 
                485                 490                 495     


Glu Cys Gly Lys Val Phe Ser Gln His Ser Arg Leu Ala Val His Arg 
            500                 505                 510         


Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys 
        515                 520                 525             


Val Phe Ser Asp Arg Ser Ala Phe Ala Arg His Arg Arg Ile His Thr 
    530                 535                 540                 


Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Val Phe Ser Gln 
545                 550                 555                 560 


Cys Ser Arg Leu Thr Val His Arg Arg Ile His Ser Gly Glu Lys Pro 
                565                 570                 575     


Tyr Lys Cys Asn Glu Cys Gly Lys Val Tyr Ser Gln Tyr Ser His Leu 
            580                 585                 590         


Val Gly His Arg Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys His 
        595                 600                 605             


Glu Cys Gly Lys Ala Phe Asn Gln Gly Ser Thr Leu Asn Arg His Gln 
    610                 615                 620                 


Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Gln Cys Gly Asn 
625                 630                 635                 640 


Ser Phe Ser Gln Arg Val His Leu Arg Leu His Gln Thr Val His Thr 
                645                 650                 655     


Gly Asp Arg Pro Tyr Lys Cys Asn Glu Cys Gly Lys Thr Phe Lys Arg 
            660                 665                 670         


Ser Ser Asn Leu Thr Ala His Gln Ile Ile His Ala Gly Lys Lys Pro 
        675                 680                 685             


Tyr Lys Cys Asp Glu Cys Gly Lys Val Phe Arg His Ser Ser His Leu 
    690                 695                 700                 


Val Ser His Gln Arg Ile His Thr Gly Glu Lys Arg Tyr Lys Cys Ile 
705                 710                 715                 720 


Glu Cys Gly Lys Ala Phe Gly Arg Leu Phe Ser Leu Ser Lys His Gln 
                725                 730                 735     


Arg Ile His Ser Gly Lys Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys 
            740                 745                 750         


Ser Phe Ile Cys Arg Ser Gly Leu Thr Lys His Arg Ile Arg His Thr 
        755                 760                 765             


Gly Glu Ser Leu Thr Thr Lys Leu Asn Val Thr Arg Pro 
    770                 775                 780     


<210>  589
<211>  2940
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (267)..(2063)

<400>  589
atttggttga aagaaaaccc acaatccagt gtcaagaaag aagtcaactt ttcttcccct       60

acttccctgc atttctcctc tgtgctcact gccacacgca gctcaacctg gacggcacag      120

ccagaggcga gatgcttctc tgctgatctg agtctgcctg cagcatggac ctgggtcttc      180

cctgaagcat ctccagggct ggagggacga ctgccatgca ccgagggctc atccatccgc      240

agagcagggc agtgggagga gacgcc atg acc ccc atc gtc aca gtc ctg atc       293
                             Met Thr Pro Ile Val Thr Val Leu Ile          
                             1               5                            

tgt ctc ggg ctg agt ctg ggc ccc agg acc cac gtg cag aca ggg acc        341
Cys Leu Gly Leu Ser Leu Gly Pro Arg Thr His Val Gln Thr Gly Thr           
10                  15                  20                  25            

att ccc aag ccc acc ctg tgg gct gag cca gac tct gtg atc acc cag        389
Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser Val Ile Thr Gln           
                30                  35                  40                

ggg agt ccc gtc acc ctc agt tgt cag ggg agc ctt gaa gcc cag gag        437
Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu Glu Ala Gln Glu           
            45                  50                  55                    

tac cgt cta tat agg gag aaa aaa tca gca tct tgg att aca cgg ata        485
Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp Ile Thr Arg Ile           
        60                  65                  70                        

cga cca gag ctt gtg aag aac ggc cag ttc cac atc cca tcc atc acc        533
Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile Pro Ser Ile Thr           
    75                  80                  85                            

tgg gaa cac aca ggg cga tat ggc tgt cag tat tac agc cgc gct cgg        581
Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr Ser Arg Ala Arg           
90                  95                  100                 105           

tgg tct gag ctc agt gac ccc ctg gtg ctg gtg atg aca gga gcc tac        629
Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met Thr Gly Ala Tyr           
                110                 115                 120               

cca aaa ccc acc ctc tca gcc cag ccc agc cct gtg gtg acc tca gga        677
Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val Thr Ser Gly           
            125                 130                 135                   

gga agg gtg acc ctc cag tgt gag tca cag gtg gca ttt ggc ggc ttc        725
Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala Phe Gly Gly Phe           
        140                 145                 150                       

att ctg tgt aag gaa gga gaa gaa gaa cac cca caa tgc ctg aac tcc        773
Ile Leu Cys Lys Glu Gly Glu Glu Glu His Pro Gln Cys Leu Asn Ser           
    155                 160                 165                           

cag ccc cat gcc cgt ggg tcg tcc cgc gcc atc ttc tcc gtg ggc ccc        821
Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser Val Gly Pro           
170                 175                 180                 185           

gtg agc ccg aat cgc agg tgg tcg cac agg tgc tat ggt tat gac ttg        869
Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr Gly Tyr Asp Leu           
                190                 195                 200               

aac tct ccc tat gtg tgg tct tca ccc agt gat ctc ctg gag ctc ctg        917
Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu Leu Glu Leu Leu           
            205                 210                 215                   

gtc cca ggt gtt tct aag aag cca tca ctc tca gtg cag ccg ggt cct        965
Val Pro Gly Val Ser Lys Lys Pro Ser Leu Ser Val Gln Pro Gly Pro           
        220                 225                 230                       

gtc gtg gcc cct ggg gaa agc ctg acc ctc cag tgt gtc tct gat gtc       1013
Val Val Ala Pro Gly Glu Ser Leu Thr Leu Gln Cys Val Ser Asp Val           
    235                 240                 245                           

ggc tat gac aga ttt gtt ctg tac aag gag ggg gaa cgt gac ctt cgc       1061
Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Gly Glu Arg Asp Leu Arg           
250                 255                 260                 265           

cag ctc cct ggc cgg cag ccc cag gct ggg ctc tcc cag gcc aac ttc       1109
Gln Leu Pro Gly Arg Gln Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe           
                270                 275                 280               

acc ctg ggc cct gtg agc cgc tcc tac ggg ggc cag tac aga tgc tac       1157
Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr           
            285                 290                 295                   

ggt gca cac aac ctc tcc tct gag tgc tcg gcc ccc agc gac ccc ctg       1205
Gly Ala His Asn Leu Ser Ser Glu Cys Ser Ala Pro Ser Asp Pro Leu           
        300                 305                 310                       

gac atc ctg atc aca gga cag atc cgt ggc aca ccc ttc atc tca gtg       1253
Asp Ile Leu Ile Thr Gly Gln Ile Arg Gly Thr Pro Phe Ile Ser Val           
    315                 320                 325                           

cag cca ggc ccc aca gtg gcc tca gga gag aac gtg acc ctg ctg tgt       1301
Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val Thr Leu Leu Cys           
330                 335                 340                 345           

cag tca tgg cgg cag ttc cac act ttc ctt ctg acc aag gcg gga gca       1349
Gln Ser Trp Arg Gln Phe His Thr Phe Leu Leu Thr Lys Ala Gly Ala           
                350                 355                 360               

gct gat gcc cca ctc cgt cta aga tca ata cac gaa tat cct aag tac       1397
Ala Asp Ala Pro Leu Arg Leu Arg Ser Ile His Glu Tyr Pro Lys Tyr           
            365                 370                 375                   

cag gct gaa ttc ccc atg agt cct gtg acc tca gcc cac gcg ggg acc       1445
Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Ala His Ala Gly Thr           
        380                 385                 390                       

tac agg tgc tac ggc tca ctc aac tcc gac ccc tac ctg ctg tct cac       1493
Tyr Arg Cys Tyr Gly Ser Leu Asn Ser Asp Pro Tyr Leu Leu Ser His           
    395                 400                 405                           

ccc agt gag ccc ctg gag ctc gtg gtc tca gga ccc tcc atg ggt tcc       1541
Pro Ser Glu Pro Leu Glu Leu Val Val Ser Gly Pro Ser Met Gly Ser           
410                 415                 420                 425           

agc ccc cca ccc acc ggt ccc atc tcc aca cct gca ggc cct gag gac       1589
Ser Pro Pro Pro Thr Gly Pro Ile Ser Thr Pro Ala Gly Pro Glu Asp           
                430                 435                 440               

cag ccc ctc acc ccc act ggg tcg gat ccc caa agt ggt ctg gga agg       1637
Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg           
            445                 450                 455                   

cac ctg ggg gtt gtg atc ggc atc ttg gtg gcc gtc gtc cta ctg ctc       1685
His Leu Gly Val Val Ile Gly Ile Leu Val Ala Val Val Leu Leu Leu           
        460                 465                 470                       

ctc ctc ctc ctc ctc ctc ttc ctc atc ctc cga cat cga cgt cag ggc       1733
Leu Leu Leu Leu Leu Leu Phe Leu Ile Leu Arg His Arg Arg Gln Gly           
    475                 480                 485                           

aaa cac tgg aca tcg acc cag aga aag gct gat ttc caa cat cct gca       1781
Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala           
490                 495                 500                 505           

ggg gct gtg ggg cca gag ccc aca gac aga ggc ctg cag tgg agg tcc       1829
Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser           
                510                 515                 520               

agc cca gct gcc gac gcc cag gaa gaa aac ctc tat gct gcc gtg aag       1877
Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys           
            525                 530                 535                   

gac aca cag cct gaa gat ggg gtg gag atg gac act cgg gct gct gca       1925
Asp Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ala Ala Ala           
        540                 545                 550                       

tct gaa gcc ccc cag gat gtg acc tac gcc cag ctg cac agc ttg acc       1973
Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr           
    555                 560                 565                           

ctc aga cgg aag gca act gag cct cct cca tcc cag gaa agg gaa cct       2021
Leu Arg Arg Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu Arg Glu Pro           
570                 575                 580                 585           

cca gct gag ccc agc atc tac gcc acc ctg gcc atc cac tag               2063
Pro Ala Glu Pro Ser Ile Tyr Ala Thr Leu Ala Ile His                       
                590                 595                                   

cccggagggt acgcagactc cacactcagt agaaggagac tcaggactgc tgaaggcacg     2123

ggagctgccc ccagtggaca ccaatgaacc ccagtcagcc tggaccccta acaaagacca     2183

tgaggagatg ctgggaactt tgggactcac ttgattctgc agtcgaaata actaatatcc     2243

ctacattttt taattaaagc aacagacttc tcaataatca atgagttaac cgagaaaact     2303

aaaatcagaa gtaagaatgt gctttaaact gaatcacaat ataaatatta cacatcacac     2363

aatgaaattg aaaaagtaca aaccacaaat gaaaaaagta gaaacgaaaa aaaaaaacta     2423

ggaaatgaat gacgttggct ttcgtataag gaatttagaa aaagaataac caattattcc     2483

aaatgaaggt gtaagaaagg gaataagaag aagaagagtt gctcatgagg aaaaaccaaa     2543

acttgaaaat tcaacaaagc caatgaagct cattcttgaa aatattaatt acagtcataa     2603

atcctaacta cattgagcaa gagaaagaaa gagcaggcac gcatttccat atgggagtga     2663

gccagcagac agcccagcag atcctacaca cattttcaca aactaacccc agaacaggct     2723

gcaaacctat accaatatac tagaaaatgc agattaaatg gatgaaatat tcaaaactgg     2783

agtttacata atgaacgtaa gagtaatcag agaatctgac tcattttaaa tgtgtgtgta     2843

tgtgtgtgta tatatatgtg tgtgtgtgtg tgtgtgtgtg tgtgtgaaaa acattgactg     2903

taataaaaat gttcccatcg taaaaaaaaa aaaaaaa                              2940


<210>  590
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  590

Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn 
65                  70                  75                  80  


Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro 
            100                 105                 110         


Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys 
    130                 135                 140                 


Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu 
145                 150                 155                 160 


Glu Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser 
                165                 170                 175     


Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp 
            180                 185                 190         


Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser 
        195                 200                 205             


Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys 
    210                 215                 220                 


Pro Ser Leu Ser Val Gln Pro Gly Pro Val Val Ala Pro Gly Glu Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Cys Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Arg Gly Thr Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu 
385                 390                 395                 400 


Asn Ser Asp Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Val Val Ser Gly Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro 
            420                 425                 430         


Ile Ser Thr Pro Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val 
545                 550                 555                 560 


Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu 
                565                 570                 575     


Pro Pro Pro Ser Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr 
            580                 585                 590         


Ala Thr Leu Ala Ile His 
        595             


<210>  591
<211>  1834
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (116)..(1600)

<400>  591
gccgagccca gctccccgcg gcggccgcta gcccccggcc ccgagccacc actccgacct       60

agcggccgcc gcccccggtg cgggatgagg agatccgcgg ccgccactgg gcccc atg       118
                                                             Met          
                                                             1            

gag gag ccg cag ccg ccc cgc cca cca gcg agc atg gcc tta ctg ggc        166
Glu Glu Pro Gln Pro Pro Arg Pro Pro Ala Ser Met Ala Leu Leu Gly           
            5                   10                  15                    

agc cag cac tcc ggc gcc ccc tcc gcg gcc ggc cca cct ggc ggg act        214
Ser Gln His Ser Gly Ala Pro Ser Ala Ala Gly Pro Pro Gly Gly Thr           
        20                  25                  30                        

tcc tcc gcg gcc acg gcg gcc gtg ctc tcc ttc agc acc gtg gcg acc        262
Ser Ser Ala Ala Thr Ala Ala Val Leu Ser Phe Ser Thr Val Ala Thr           
    35                  40                  45                            

gcg gcg ctg ggg aac ctg agc gac gca agc gga ggc ggc aca gct gcc        310
Ala Ala Leu Gly Asn Leu Ser Asp Ala Ser Gly Gly Gly Thr Ala Ala           
50                  55                  60                  65            

gct ccc ggt ggc ggc ggc ctt ggc ggg tcc ggg gca gcg cgg gag gcg        358
Ala Pro Gly Gly Gly Gly Leu Gly Gly Ser Gly Ala Ala Arg Glu Ala           
                70                  75                  80                

ggg gcg gcg gtg agg cgg ccg cta ggc ccg gag gcg gcg ccg ctg ctg        406
Gly Ala Ala Val Arg Arg Pro Leu Gly Pro Glu Ala Ala Pro Leu Leu           
            85                  90                  95                    

tcg cac gga gct gca gtg gcg gcc cag gcg ctc gtc ctc ctg ctc atc        454
Ser His Gly Ala Ala Val Ala Ala Gln Ala Leu Val Leu Leu Leu Ile           
        100                 105                 110                       

ttc ctg ctg tct agc ctt ggc aac tgc gcg gtg atg ggg gtg att gtg        502
Phe Leu Leu Ser Ser Leu Gly Asn Cys Ala Val Met Gly Val Ile Val           
    115                 120                 125                           

aag cac cgg cag ctc cgc acc gtc acc aac gcc ttc atc ctg tcg ctg        550
Lys His Arg Gln Leu Arg Thr Val Thr Asn Ala Phe Ile Leu Ser Leu           
130                 135                 140                 145           

tcc cta tcg gat ctg ctc acg gcg ctg ctc tgc ctg ccc gcc gcc ttc        598
Ser Leu Ser Asp Leu Leu Thr Ala Leu Leu Cys Leu Pro Ala Ala Phe           
                150                 155                 160               

ctg gac ctc ttc act ccg ccc ggg ggt tcg gcg cct gcc gcc gcc gcg        646
Leu Asp Leu Phe Thr Pro Pro Gly Gly Ser Ala Pro Ala Ala Ala Ala           
            165                 170                 175                   

ggg ccc tgg cgc ggc ttc tgc gcc gcc agc cgc ttc ttc agc tcg tgc        694
Gly Pro Trp Arg Gly Phe Cys Ala Ala Ser Arg Phe Phe Ser Ser Cys           
        180                 185                 190                       

ttc ggc atc gtg tcc acg ctc agc gtg gcg ctc atc tcg ttg gac cgt        742
Phe Gly Ile Val Ser Thr Leu Ser Val Ala Leu Ile Ser Leu Asp Arg           
    195                 200                 205                           

tac tgc gct atc gtg cgg ccg ccg cgg gag aag atc ggc cgc cgc cgc        790
Tyr Cys Ala Ile Val Arg Pro Pro Arg Glu Lys Ile Gly Arg Arg Arg           
210                 215                 220                 225           

gcg ctg cag ctg ctg gcg ggc gcc tgg ctg acg gcc ctg ggc ttc tcc        838
Ala Leu Gln Leu Leu Ala Gly Ala Trp Leu Thr Ala Leu Gly Phe Ser           
                230                 235                 240               

ttg ccc tgg gag ctg ctc ggg gcg ccc cgg gaa ctc gcg gcg gcg cag        886
Leu Pro Trp Glu Leu Leu Gly Ala Pro Arg Glu Leu Ala Ala Ala Gln           
            245                 250                 255                   

agc ttc cac ggc tgc ctc tac cgg acc tcc ccg gac ccc gcg cag ctg        934
Ser Phe His Gly Cys Leu Tyr Arg Thr Ser Pro Asp Pro Ala Gln Leu           
        260                 265                 270                       

ggc gcg gcc ttc agc gtg ggg ctg gtg gtg gcc tgc tac ctg ctg ccc        982
Gly Ala Ala Phe Ser Val Gly Leu Val Val Ala Cys Tyr Leu Leu Pro           
    275                 280                 285                           

ttc ctg ctc atg tgc ttc tgc cac tac cac atc tgc aag acg gtg cgc       1030
Phe Leu Leu Met Cys Phe Cys His Tyr His Ile Cys Lys Thr Val Arg           
290                 295                 300                 305           

ctg tcg gac gtg cgc gtg cgg ccg gtg aac acc tac gcg cgc gtg ctg       1078
Leu Ser Asp Val Arg Val Arg Pro Val Asn Thr Tyr Ala Arg Val Leu           
                310                 315                 320               

cgc ttc ttc agc gag gtg cgc acg gcc acc acc gtc ctc atc atg atc       1126
Arg Phe Phe Ser Glu Val Arg Thr Ala Thr Thr Val Leu Ile Met Ile           
            325                 330                 335                   

gtc ttc gtc atc tgc tgc tgg ggg ccc tac tgc ttc ctg gtg ctg ctg       1174
Val Phe Val Ile Cys Cys Trp Gly Pro Tyr Cys Phe Leu Val Leu Leu           
        340                 345                 350                       

gcc gcc gcc cgg cag gcc cag acc atg cag gcc ccc tcg ctc ctc agc       1222
Ala Ala Ala Arg Gln Ala Gln Thr Met Gln Ala Pro Ser Leu Leu Ser           
    355                 360                 365                           

gtg gtg gcc gtc tgg ctg acc tgg gcc aat ggg gcc atc aac cct gtc       1270
Val Val Ala Val Trp Leu Thr Trp Ala Asn Gly Ala Ile Asn Pro Val           
370                 375                 380                 385           

atc tac gcc atc cgc aat ccc aac att tcg atg ctc cta ggg cgc aac       1318
Ile Tyr Ala Ile Arg Asn Pro Asn Ile Ser Met Leu Leu Gly Arg Asn           
                390                 395                 400               

cgc gag gag ggc tac cgg act agg aat gtg gac gct ttc ctg ccc agc       1366
Arg Glu Glu Gly Tyr Arg Thr Arg Asn Val Asp Ala Phe Leu Pro Ser           
            405                 410                 415                   

cag ggc ccg ggt ctg caa gcc aga agc cgc agt cgc ctt cga aac cgc       1414
Gln Gly Pro Gly Leu Gln Ala Arg Ser Arg Ser Arg Leu Arg Asn Arg           
        420                 425                 430                       

tat gcc aac cgg ctg ggg gcc tgc aac agg atg tcc tct tcc aac ccg       1462
Tyr Ala Asn Arg Leu Gly Ala Cys Asn Arg Met Ser Ser Ser Asn Pro           
    435                 440                 445                           

gcc agc gga gtg gca ggg gac gtg gcc atg tgg gcc cgc aaa aat cca       1510
Ala Ser Gly Val Ala Gly Asp Val Ala Met Trp Ala Arg Lys Asn Pro           
450                 455                 460                 465           

gtt gta ctt ttc tgc cga gag gga cca cca gag ccg gtg acg gca gtg       1558
Val Val Leu Phe Cys Arg Glu Gly Pro Pro Glu Pro Val Thr Ala Val           
                470                 475                 480               

acc aaa cag cct aaa tcc gaa gct ggg gat acc agc ctc taa               1600
Thr Lys Gln Pro Lys Ser Glu Ala Gly Asp Thr Ser Leu                       
            485                 490                                       

gacggttgga atggccagct tatgaaggca aatttccact cgcattattt aatgatggaa     1660

gattctgggg gagagttgtg gatttcataa agccaaacat ttaaagctag agacggggga     1720

ggcttaccac tttccccaaa caacataaaa gacaatgtcc cttcttcaaa agtgccaaaa     1780

ggaatgtaaa atgcaaaaat taaaacaatc ttaaaccaca aaaaaaaaaa aaaa           1834


<210>  592
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  592

Met Glu Glu Pro Gln Pro Pro Arg Pro Pro Ala Ser Met Ala Leu Leu 
1               5                   10                  15      


Gly Ser Gln His Ser Gly Ala Pro Ser Ala Ala Gly Pro Pro Gly Gly 
            20                  25                  30          


Thr Ser Ser Ala Ala Thr Ala Ala Val Leu Ser Phe Ser Thr Val Ala 
        35                  40                  45              


Thr Ala Ala Leu Gly Asn Leu Ser Asp Ala Ser Gly Gly Gly Thr Ala 
    50                  55                  60                  


Ala Ala Pro Gly Gly Gly Gly Leu Gly Gly Ser Gly Ala Ala Arg Glu 
65                  70                  75                  80  


Ala Gly Ala Ala Val Arg Arg Pro Leu Gly Pro Glu Ala Ala Pro Leu 
                85                  90                  95      


Leu Ser His Gly Ala Ala Val Ala Ala Gln Ala Leu Val Leu Leu Leu 
            100                 105                 110         


Ile Phe Leu Leu Ser Ser Leu Gly Asn Cys Ala Val Met Gly Val Ile 
        115                 120                 125             


Val Lys His Arg Gln Leu Arg Thr Val Thr Asn Ala Phe Ile Leu Ser 
    130                 135                 140                 


Leu Ser Leu Ser Asp Leu Leu Thr Ala Leu Leu Cys Leu Pro Ala Ala 
145                 150                 155                 160 


Phe Leu Asp Leu Phe Thr Pro Pro Gly Gly Ser Ala Pro Ala Ala Ala 
                165                 170                 175     


Ala Gly Pro Trp Arg Gly Phe Cys Ala Ala Ser Arg Phe Phe Ser Ser 
            180                 185                 190         


Cys Phe Gly Ile Val Ser Thr Leu Ser Val Ala Leu Ile Ser Leu Asp 
        195                 200                 205             


Arg Tyr Cys Ala Ile Val Arg Pro Pro Arg Glu Lys Ile Gly Arg Arg 
    210                 215                 220                 


Arg Ala Leu Gln Leu Leu Ala Gly Ala Trp Leu Thr Ala Leu Gly Phe 
225                 230                 235                 240 


Ser Leu Pro Trp Glu Leu Leu Gly Ala Pro Arg Glu Leu Ala Ala Ala 
                245                 250                 255     


Gln Ser Phe His Gly Cys Leu Tyr Arg Thr Ser Pro Asp Pro Ala Gln 
            260                 265                 270         


Leu Gly Ala Ala Phe Ser Val Gly Leu Val Val Ala Cys Tyr Leu Leu 
        275                 280                 285             


Pro Phe Leu Leu Met Cys Phe Cys His Tyr His Ile Cys Lys Thr Val 
    290                 295                 300                 


Arg Leu Ser Asp Val Arg Val Arg Pro Val Asn Thr Tyr Ala Arg Val 
305                 310                 315                 320 


Leu Arg Phe Phe Ser Glu Val Arg Thr Ala Thr Thr Val Leu Ile Met 
                325                 330                 335     


Ile Val Phe Val Ile Cys Cys Trp Gly Pro Tyr Cys Phe Leu Val Leu 
            340                 345                 350         


Leu Ala Ala Ala Arg Gln Ala Gln Thr Met Gln Ala Pro Ser Leu Leu 
        355                 360                 365             


Ser Val Val Ala Val Trp Leu Thr Trp Ala Asn Gly Ala Ile Asn Pro 
    370                 375                 380                 


Val Ile Tyr Ala Ile Arg Asn Pro Asn Ile Ser Met Leu Leu Gly Arg 
385                 390                 395                 400 


Asn Arg Glu Glu Gly Tyr Arg Thr Arg Asn Val Asp Ala Phe Leu Pro 
                405                 410                 415     


Ser Gln Gly Pro Gly Leu Gln Ala Arg Ser Arg Ser Arg Leu Arg Asn 
            420                 425                 430         


Arg Tyr Ala Asn Arg Leu Gly Ala Cys Asn Arg Met Ser Ser Ser Asn 
        435                 440                 445             


Pro Ala Ser Gly Val Ala Gly Asp Val Ala Met Trp Ala Arg Lys Asn 
    450                 455                 460                 


Pro Val Val Leu Phe Cys Arg Glu Gly Pro Pro Glu Pro Val Thr Ala 
465                 470                 475                 480 


Val Thr Lys Gln Pro Lys Ser Glu Ala Gly Asp Thr Ser Leu 
                485                 490                 


<210>  593
<211>  7165
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (476)..(5722)

<400>  593
cgggcatgct cagtgggccg ggccggcagg tttgcgtggc cgctgagttg ccggcgccgg       60

ctgagccagc ggacgccgcg ttccttggcg gccgccggtt cccgggaagt tacgtggcga      120

agccggcttc cgaggagacg ccgggaggcc acgggtgctg ctgacgggcg ggcgaccggg      180

cgaggccgac gtggccgggc tgcgaaagct gcgggaggcc gagtgggtgg ccgcgctcgg      240

agggaggtgc cggtcgggcg cgccccgtgg agaagacccg ggcggggcgg gcgcttcccg      300

gacttttgtc cgagttgaat tccctccccc tgggccgggc ccttccggcc gcccccgccc      360

gtgccccgct cgctctcggg agatgtttat ttgggctgtg gcgtgaggag cgggcgggcc      420

agcgccgcgg agtttcgggt ccgaggagcc tcgcgcggcg ctggagagag acaag atg       478
                                                             Met          
                                                             1            

tcc gcc aga gct gcg gcc gcc aag agc aca gca atg gag gaa aca gct        526
Ser Ala Arg Ala Ala Ala Ala Lys Ser Thr Ala Met Glu Glu Thr Ala           
            5                   10                  15                    

ata tgg gaa caa cat aca gtg acg ctt cac agg gct cct gga ttt gga        574
Ile Trp Glu Gln His Thr Val Thr Leu His Arg Ala Pro Gly Phe Gly           
        20                  25                  30                        

ttt gga att gca ata tct ggt gga cga gat aat cct cat ttt cag agt        622
Phe Gly Ile Ala Ile Ser Gly Gly Arg Asp Asn Pro His Phe Gln Ser           
    35                  40                  45                            

ggg gaa acg tca ata gtg att tca gat gtg ctg aaa gga gga cca gct        670
Gly Glu Thr Ser Ile Val Ile Ser Asp Val Leu Lys Gly Gly Pro Ala           
50                  55                  60                  65            

gaa gga cag cta cag gaa aat gac cga gtt gca atg gtt aac gga gtt        718
Glu Gly Gln Leu Gln Glu Asn Asp Arg Val Ala Met Val Asn Gly Val           
                70                  75                  80                

tca atg gat aat gtt gaa cat gct ttt gct gtt cag caa cta agg aaa        766
Ser Met Asp Asn Val Glu His Ala Phe Ala Val Gln Gln Leu Arg Lys           
            85                  90                  95                    

agt ggg aaa aat gca aaa att aca att aga agg aag aag aaa gtt caa        814
Ser Gly Lys Asn Ala Lys Ile Thr Ile Arg Arg Lys Lys Lys Val Gln           
        100                 105                 110                       

ata cca gta agt cgt cct gat cct gaa cca gta tct gat aat gaa gaa        862
Ile Pro Val Ser Arg Pro Asp Pro Glu Pro Val Ser Asp Asn Glu Glu           
    115                 120                 125                           

gat agt tat gat gag gaa ata cat gat cca aga agt ggc cgg agt ggt        910
Asp Ser Tyr Asp Glu Glu Ile His Asp Pro Arg Ser Gly Arg Ser Gly           
130                 135                 140                 145           

gtg gtt aac aga agg agt gag aag att tgg ccg agg gat aga agt gca        958
Val Val Asn Arg Arg Ser Glu Lys Ile Trp Pro Arg Asp Arg Ser Ala           
                150                 155                 160               

agt aga gag agg agc ttg tcc ccg cgg tca gac agg cgg tca gtg gct       1006
Ser Arg Glu Arg Ser Leu Ser Pro Arg Ser Asp Arg Arg Ser Val Ala           
            165                 170                 175                   

tcc agc cag cct gct aaa cct act aaa gtc aca ctg gtg aaa tcc cgg       1054
Ser Ser Gln Pro Ala Lys Pro Thr Lys Val Thr Leu Val Lys Ser Arg           
        180                 185                 190                       

aaa aat gaa gaa tat ggt ctt cga ttg gca agc cat ata ttt gtt aag       1102
Lys Asn Glu Glu Tyr Gly Leu Arg Leu Ala Ser His Ile Phe Val Lys           
    195                 200                 205                           

gaa att tca caa gat agt ttg gca gca aga gat ggc aat att caa gaa       1150
Glu Ile Ser Gln Asp Ser Leu Ala Ala Arg Asp Gly Asn Ile Gln Glu           
210                 215                 220                 225           

ggt gat gtt gta ttg aag ata aat ggt act gtg aca gaa aat atg tca       1198
Gly Asp Val Val Leu Lys Ile Asn Gly Thr Val Thr Glu Asn Met Ser           
                230                 235                 240               

ttg aca gat gca aag aca ttg ata gaa agg tct aaa ggc aaa tta aaa       1246
Leu Thr Asp Ala Lys Thr Leu Ile Glu Arg Ser Lys Gly Lys Leu Lys           
            245                 250                 255                   

atg gta gtt caa aga gat gaa cgg gct acg cta ttg aat gtc cct gat       1294
Met Val Val Gln Arg Asp Glu Arg Ala Thr Leu Leu Asn Val Pro Asp           
        260                 265                 270                       

ctt tct gac agc atc cac tct gct aat gcc tct gag aga gac gac att       1342
Leu Ser Asp Ser Ile His Ser Ala Asn Ala Ser Glu Arg Asp Asp Ile           
    275                 280                 285                           

tca gaa att cag tca ctg gca tca gat cat tct ggt cga tca cac gat       1390
Ser Glu Ile Gln Ser Leu Ala Ser Asp His Ser Gly Arg Ser His Asp           
290                 295                 300                 305           

agg cct ccc cgc cgc agc cgg tca cga tct cct gac cag cgg tca gag       1438
Arg Pro Pro Arg Arg Ser Arg Ser Arg Ser Pro Asp Gln Arg Ser Glu           
                310                 315                 320               

cct tct gat cat tcc agg cac tcg ccg cag cag cca agc aat ggc agt       1486
Pro Ser Asp His Ser Arg His Ser Pro Gln Gln Pro Ser Asn Gly Ser           
            325                 330                 335                   

ctc cgg agt aga gat gaa gag aga att tct aaa cct ggg gct gtc tca       1534
Leu Arg Ser Arg Asp Glu Glu Arg Ile Ser Lys Pro Gly Ala Val Ser           
        340                 345                 350                       

act cct gta aag cat gct gat gat cac aca cct aaa aca gtg gaa gaa       1582
Thr Pro Val Lys His Ala Asp Asp His Thr Pro Lys Thr Val Glu Glu           
    355                 360                 365                           

gtt aca gtt gaa aga aat gag aaa caa aca cct tct ctt cca gaa cca       1630
Val Thr Val Glu Arg Asn Glu Lys Gln Thr Pro Ser Leu Pro Glu Pro           
370                 375                 380                 385           

aag cct gtg tat gcc caa gtt ggg caa cca gat gtg gat tta cct gtc       1678
Lys Pro Val Tyr Ala Gln Val Gly Gln Pro Asp Val Asp Leu Pro Val           
                390                 395                 400               

agt cca tct gat ggt gtc cta cct aat tca act cat gaa gat ggg att       1726
Ser Pro Ser Asp Gly Val Leu Pro Asn Ser Thr His Glu Asp Gly Ile           
            405                 410                 415                   

ctt cgg ccc agc atg aaa ttg gta aaa ttc aga aaa gga gat agt gtg       1774
Leu Arg Pro Ser Met Lys Leu Val Lys Phe Arg Lys Gly Asp Ser Val           
        420                 425                 430                       

ggt ttg cgg ctg gct ggt gga aat gat gtt gga ata ttt gta gct ggc       1822
Gly Leu Arg Leu Ala Gly Gly Asn Asp Val Gly Ile Phe Val Ala Gly           
    435                 440                 445                           

gtt cta gaa gat agc cct gca gcc aag gaa ggc tta gag gaa ggt gat       1870
Val Leu Glu Asp Ser Pro Ala Ala Lys Glu Gly Leu Glu Glu Gly Asp           
450                 455                 460                 465           

caa att ctc agg gta aac aac gta gat ttt aca aat atc ata aga gaa       1918
Gln Ile Leu Arg Val Asn Asn Val Asp Phe Thr Asn Ile Ile Arg Glu           
                470                 475                 480               

gaa gcc gtc ctt ttc ctg ctt gac ctc cct aaa gga gaa gaa gtg acc       1966
Glu Ala Val Leu Phe Leu Leu Asp Leu Pro Lys Gly Glu Glu Val Thr           
            485                 490                 495                   

ata ttg gct cag aag aag aag gat gtt tat cgt cgc att gta gaa tca       2014
Ile Leu Ala Gln Lys Lys Lys Asp Val Tyr Arg Arg Ile Val Glu Ser           
        500                 505                 510                       

gat gta gga gat tct ttc tat att aga acc cat ttt gaa tat gaa aag       2062
Asp Val Gly Asp Ser Phe Tyr Ile Arg Thr His Phe Glu Tyr Glu Lys           
    515                 520                 525                           

gaa tct ccc tat gga ctt agt ttt aac aaa gga gag gtg ttc cgt gtt       2110
Glu Ser Pro Tyr Gly Leu Ser Phe Asn Lys Gly Glu Val Phe Arg Val           
530                 535                 540                 545           

gtg gat acc ttg tac aat gga aaa ctg ggc tct tgg ctt gct att cga       2158
Val Asp Thr Leu Tyr Asn Gly Lys Leu Gly Ser Trp Leu Ala Ile Arg           
                550                 555                 560               

att ggt aaa aat cat aag gag gta gaa cga ggc atc atc cct aat aag       2206
Ile Gly Lys Asn His Lys Glu Val Glu Arg Gly Ile Ile Pro Asn Lys           
            565                 570                 575                   

aac aga gct gag cag cta gcc agt gta cag tat aca ctt cca aaa aca       2254
Asn Arg Ala Glu Gln Leu Ala Ser Val Gln Tyr Thr Leu Pro Lys Thr           
        580                 585                 590                       

gca ggc gga gac cgt gct gac ttc tgg aga ttc aga ggt ctt cgc agc       2302
Ala Gly Gly Asp Arg Ala Asp Phe Trp Arg Phe Arg Gly Leu Arg Ser           
    595                 600                 605                           

tcc aag aga aat ctt cga aaa agc aga gag gat ttg tcc gct cag cct       2350
Ser Lys Arg Asn Leu Arg Lys Ser Arg Glu Asp Leu Ser Ala Gln Pro           
610                 615                 620                 625           

gtt caa aca aag ttt cca gct tat gaa aga gtg gtt ctt cga gaa gct       2398
Val Gln Thr Lys Phe Pro Ala Tyr Glu Arg Val Val Leu Arg Glu Ala           
                630                 635                 640               

gga ttt ctg agg cct gta acc att ttt gga cca ata gct gat gtt gcc       2446
Gly Phe Leu Arg Pro Val Thr Ile Phe Gly Pro Ile Ala Asp Val Ala           
            645                 650                 655                   

aga gaa aag ctg gca aga gaa gaa cca gat att tat caa att gca aag       2494
Arg Glu Lys Leu Ala Arg Glu Glu Pro Asp Ile Tyr Gln Ile Ala Lys           
        660                 665                 670                       

agt gaa cca cga gac gct gga act gac caa cgt agc tct ggc att att       2542
Ser Glu Pro Arg Asp Ala Gly Thr Asp Gln Arg Ser Ser Gly Ile Ile           
    675                 680                 685                           

cgc ctg cat aca ata aag caa atc ata gat caa gac aaa cat gct tta       2590
Arg Leu His Thr Ile Lys Gln Ile Ile Asp Gln Asp Lys His Ala Leu           
690                 695                 700                 705           

tta gat gta aca cca aat gca gtt gat cgt ctt aac tat gcc cag tgg       2638
Leu Asp Val Thr Pro Asn Ala Val Asp Arg Leu Asn Tyr Ala Gln Trp           
                710                 715                 720               

tat cca att gtt gta ttt ctt aac cct gat tct aag caa gga gta aaa       2686
Tyr Pro Ile Val Val Phe Leu Asn Pro Asp Ser Lys Gln Gly Val Lys           
            725                 730                 735                   

aca atg aga atg agg tta tgt cca gaa tct cgg aaa agt gcc agg aag       2734
Thr Met Arg Met Arg Leu Cys Pro Glu Ser Arg Lys Ser Ala Arg Lys           
        740                 745                 750                       

tta tac gag cga tct cat aaa ctt cgt aaa aat aat cac cat ctt ttt       2782
Leu Tyr Glu Arg Ser His Lys Leu Arg Lys Asn Asn His His Leu Phe           
    755                 760                 765                           

aca act aca att aac tta aat tca atg aat gat ggt tgg tat ggt gcg       2830
Thr Thr Thr Ile Asn Leu Asn Ser Met Asn Asp Gly Trp Tyr Gly Ala           
770                 775                 780                 785           

ctg aaa gaa gca att caa caa cag caa aac cag ctg gta tgg gtt tcc       2878
Leu Lys Glu Ala Ile Gln Gln Gln Gln Asn Gln Leu Val Trp Val Ser           
                790                 795                 800               

gag gga aag gcg gat ggt gct aca agt gat gac ctt gat ttg cat gat       2926
Glu Gly Lys Ala Asp Gly Ala Thr Ser Asp Asp Leu Asp Leu His Asp           
            805                 810                 815                   

gat cgt ctg tcc tac ctg tca gct cca ggt agt gaa tac tca atg tat       2974
Asp Arg Leu Ser Tyr Leu Ser Ala Pro Gly Ser Glu Tyr Ser Met Tyr           
        820                 825                 830                       

agc acg gac agt aga cac act tct gac tat gaa gac aca gac aca gaa       3022
Ser Thr Asp Ser Arg His Thr Ser Asp Tyr Glu Asp Thr Asp Thr Glu           
    835                 840                 845                           

ggc ggg gcc tac act gat caa gaa cta gat gaa act ctt aat gat gag       3070
Gly Gly Ala Tyr Thr Asp Gln Glu Leu Asp Glu Thr Leu Asn Asp Glu           
850                 855                 860                 865           

gtt ggg act cca ccg gag tct gcc att aca cgg tcc tct gag cct gta       3118
Val Gly Thr Pro Pro Glu Ser Ala Ile Thr Arg Ser Ser Glu Pro Val           
                870                 875                 880               

aga gag gac tcc tct gga atg cat cat gaa aac caa aca tat cct cct       3166
Arg Glu Asp Ser Ser Gly Met His His Glu Asn Gln Thr Tyr Pro Pro           
            885                 890                 895                   

tac tca cca caa gcg cag cca caa cca att cat aga ata gac tcc cct       3214
Tyr Ser Pro Gln Ala Gln Pro Gln Pro Ile His Arg Ile Asp Ser Pro           
        900                 905                 910                       

gga ttt aag cca gcc tct caa cag aaa gca gaa gct tca tct cca gtc       3262
Gly Phe Lys Pro Ala Ser Gln Gln Lys Ala Glu Ala Ser Ser Pro Val           
    915                 920                 925                           

cct tac ctt tcg cct gaa aca aac cca gca tca tca acc tct gct gtt       3310
Pro Tyr Leu Ser Pro Glu Thr Asn Pro Ala Ser Ser Thr Ser Ala Val           
930                 935                 940                 945           

aat cat aat gta aat tta act aat gtc aga ctg gag gag ccc acc cca       3358
Asn His Asn Val Asn Leu Thr Asn Val Arg Leu Glu Glu Pro Thr Pro           
                950                 955                 960               

gct cct tcc acc tct tac tca cca caa gct gat tct tta aga aca cca       3406
Ala Pro Ser Thr Ser Tyr Ser Pro Gln Ala Asp Ser Leu Arg Thr Pro           
            965                 970                 975                   

agt act gag gca gct cac ata atg cta aga gat caa gaa cca tca ttg       3454
Ser Thr Glu Ala Ala His Ile Met Leu Arg Asp Gln Glu Pro Ser Leu           
        980                 985                 990                       

tcg tcg cat gta gat cca aca  aag gtg tat aga aag  gat cca tat ccc     3502
Ser Ser His Val Asp Pro Thr  Lys Val Tyr Arg Lys  Asp Pro Tyr Pro         
    995                 1000                 1005                         

gag  gaa atg atg agg cag  aac cat gtt ttg aaa  cag cca gcc gtt        3547
Glu  Glu Met Met Arg Gln  Asn His Val Leu Lys  Gln Pro Ala Val            
1010                 1015                 1020                            

agt  cac cca ggg cac agg  cca gac aaa gag cct  aat ctg acc tat        3592
Ser  His Pro Gly His Arg  Pro Asp Lys Glu Pro  Asn Leu Thr Tyr            
1025                 1030                 1035                            

gaa  ccc caa ctc cca tac  gta gag aaa caa gcc  agc aga gac ctc        3637
Glu  Pro Gln Leu Pro Tyr  Val Glu Lys Gln Ala  Ser Arg Asp Leu            
1040                 1045                 1050                            

gag  cag ccc aca tac aga  tac gag tcc tca agc  tat acg gac cag        3682
Glu  Gln Pro Thr Tyr Arg  Tyr Glu Ser Ser Ser  Tyr Thr Asp Gln            
1055                 1060                 1065                            

ttt  tct cga aac tat gaa  cat cgt ctg cga tac  gaa gat cgc gtc        3727
Phe  Ser Arg Asn Tyr Glu  His Arg Leu Arg Tyr  Glu Asp Arg Val            
1070                 1075                 1080                            

ccc  atg tat gaa gaa cag  tgg tca tat tat gat  gac aaa cag ccc        3772
Pro  Met Tyr Glu Glu Gln  Trp Ser Tyr Tyr Asp  Asp Lys Gln Pro            
1085                 1090                 1095                            

tac  cca tct cgg cca cct  ttt gat aat cag cac  tct caa gac ctt        3817
Tyr  Pro Ser Arg Pro Pro  Phe Asp Asn Gln His  Ser Gln Asp Leu            
1100                 1105                 1110                            

gac  tcc aga cag cat ccc  gaa gag tcc tca gaa  cga ggg tac ttt        3862
Asp  Ser Arg Gln His Pro  Glu Glu Ser Ser Glu  Arg Gly Tyr Phe            
1115                 1120                 1125                            

cca  cgt ttt gaa gag cca  gcc cct ctg tct tac  gac agc aga cca        3907
Pro  Arg Phe Glu Glu Pro  Ala Pro Leu Ser Tyr  Asp Ser Arg Pro            
1130                 1135                 1140                            

cgt  tac gaa cag gca cct  aga gca tcc gcc ctg  cgg cac gaa gag        3952
Arg  Tyr Glu Gln Ala Pro  Arg Ala Ser Ala Leu  Arg His Glu Glu            
1145                 1150                 1155                            

cag  cca gct cct ggg tat  gac aca cat ggt aga  ctc aga ccg gaa        3997
Gln  Pro Ala Pro Gly Tyr  Asp Thr His Gly Arg  Leu Arg Pro Glu            
1160                 1165                 1170                            

gcc  cag ccc cac cct tca  gca ggg ccc aag cct  gca gag tcc aag        4042
Ala  Gln Pro His Pro Ser  Ala Gly Pro Lys Pro  Ala Glu Ser Lys            
1175                 1180                 1185                            

cag  tat ttt gag caa tat  tca cgc agt tac gag  caa gta cca ccc        4087
Gln  Tyr Phe Glu Gln Tyr  Ser Arg Ser Tyr Glu  Gln Val Pro Pro            
1190                 1195                 1200                            

caa  gga ttt acc tct aga  gca ggt cat ttt gag  cct ctc cat ggt        4132
Gln  Gly Phe Thr Ser Arg  Ala Gly His Phe Glu  Pro Leu His Gly            
1205                 1210                 1215                            

gct  gca gct gtc cct ccg  ctg ata cct tca tct  cag cat aag cca        4177
Ala  Ala Ala Val Pro Pro  Leu Ile Pro Ser Ser  Gln His Lys Pro            
1220                 1225                 1230                            

gaa  gct ctg cct tca aac  acc aaa cca ctg cct  cca ccc cca act        4222
Glu  Ala Leu Pro Ser Asn  Thr Lys Pro Leu Pro  Pro Pro Pro Thr            
1235                 1240                 1245                            

caa  acc gaa gaa gag gaa  gat cca gca atg aag  cca cag tct gta        4267
Gln  Thr Glu Glu Glu Glu  Asp Pro Ala Met Lys  Pro Gln Ser Val            
1250                 1255                 1260                            

ctc  acc aga gtt aag atg  ttt gaa aac aaa aga  tct gca tcc tta        4312
Leu  Thr Arg Val Lys Met  Phe Glu Asn Lys Arg  Ser Ala Ser Leu            
1265                 1270                 1275                            

gag  acc aag aag gat gta  aat gac act ggc agt  ttt aag cct cca        4357
Glu  Thr Lys Lys Asp Val  Asn Asp Thr Gly Ser  Phe Lys Pro Pro            
1280                 1285                 1290                            

gaa  gta gca tct aaa cct  tca ggt gct ccc atc  att ggt ccc aaa        4402
Glu  Val Ala Ser Lys Pro  Ser Gly Ala Pro Ile  Ile Gly Pro Lys            
1295                 1300                 1305                            

ccc  act tct cag aat caa  ttc agt gaa cat gac  aaa act ctg tac        4447
Pro  Thr Ser Gln Asn Gln  Phe Ser Glu His Asp  Lys Thr Leu Tyr            
1310                 1315                 1320                            

agg  atc cca gaa cct caa  aaa cct caa ctg aag  cca cct gaa gat        4492
Arg  Ile Pro Glu Pro Gln  Lys Pro Gln Leu Lys  Pro Pro Glu Asp            
1325                 1330                 1335                            

att  gtt cgg tcc aat cat  tat gac cct gaa gaa  gat gaa gaa tat        4537
Ile  Val Arg Ser Asn His  Tyr Asp Pro Glu Glu  Asp Glu Glu Tyr            
1340                 1345                 1350                            

tat  cga aaa cag ctg tca  tac ttt gac cga aga  agt ttt gag aat        4582
Tyr  Arg Lys Gln Leu Ser  Tyr Phe Asp Arg Arg  Ser Phe Glu Asn            
1355                 1360                 1365                            

aag  cct cct gca cac att  gcc gcc agc cat ctc  tcc gag cct gca        4627
Lys  Pro Pro Ala His Ile  Ala Ala Ser His Leu  Ser Glu Pro Ala            
1370                 1375                 1380                            

aag  cca gcg cat tct cag  aat caa tca aat ttt  tct agt tat tct        4672
Lys  Pro Ala His Ser Gln  Asn Gln Ser Asn Phe  Ser Ser Tyr Ser            
1385                 1390                 1395                            

tca  aag gga aag cct cct  gaa gct gat ggt gtg  gat aga tca ttt        4717
Ser  Lys Gly Lys Pro Pro  Glu Ala Asp Gly Val  Asp Arg Ser Phe            
1400                 1405                 1410                            

ggc  gag aaa cgc tat gaa  ccc atc cag gcc act  ccc cct cct cct        4762
Gly  Glu Lys Arg Tyr Glu  Pro Ile Gln Ala Thr  Pro Pro Pro Pro            
1415                 1420                 1425                            

cca  ttg ccc tcg cag tat  gcc cag cca tct cag  cct gtc acc agc        4807
Pro  Leu Pro Ser Gln Tyr  Ala Gln Pro Ser Gln  Pro Val Thr Ser            
1430                 1435                 1440                            

gcg  tct ctc cac ata cat  tct aag gga gca cat  ggt gaa ggt aat        4852
Ala  Ser Leu His Ile His  Ser Lys Gly Ala His  Gly Glu Gly Asn            
1445                 1450                 1455                            

tca  gtg tca ttg gat ttt  cag aat tcc tta gtg  tcc aaa cca gac        4897
Ser  Val Ser Leu Asp Phe  Gln Asn Ser Leu Val  Ser Lys Pro Asp            
1460                 1465                 1470                            

cca  cct cca tct cag aat  aag cca gca act ttc  aga cca cca aac        4942
Pro  Pro Pro Ser Gln Asn  Lys Pro Ala Thr Phe  Arg Pro Pro Asn            
1475                 1480                 1485                            

cga  gaa gat act gct cag  gca gct ttc tat ccc  cag aaa agt ttt        4987
Arg  Glu Asp Thr Ala Gln  Ala Ala Phe Tyr Pro  Gln Lys Ser Phe            
1490                 1495                 1500                            

cca  gat aaa gcc cca gtt  aat gga act gaa cag  act cag aaa aca        5032
Pro  Asp Lys Ala Pro Val  Asn Gly Thr Glu Gln  Thr Gln Lys Thr            
1505                 1510                 1515                            

gtc  act cca gca tac aat  cga ttc aca cca aaa  cca tat aca agt        5077
Val  Thr Pro Ala Tyr Asn  Arg Phe Thr Pro Lys  Pro Tyr Thr Ser            
1520                 1525                 1530                            

tct  gcc cga cca ttt gaa  cgc aag ttt gaa agt  cct aaa ttc aat        5122
Ser  Ala Arg Pro Phe Glu  Arg Lys Phe Glu Ser  Pro Lys Phe Asn            
1535                 1540                 1545                            

cac  aat ctt ctg cca agt  gaa act gca cat aaa  cct gac ttg tct        5167
His  Asn Leu Leu Pro Ser  Glu Thr Ala His Lys  Pro Asp Leu Ser            
1550                 1555                 1560                            

tca  aaa act ccc act tct  cca aaa act ctt gtg  aaa tcg cac agt        5212
Ser  Lys Thr Pro Thr Ser  Pro Lys Thr Leu Val  Lys Ser His Ser            
1565                 1570                 1575                            

ttg  gca cag cct cct gag  ttt gac agt gga gtt  gaa act ttc tct        5257
Leu  Ala Gln Pro Pro Glu  Phe Asp Ser Gly Val  Glu Thr Phe Ser            
1580                 1585                 1590                            

atc  cat gca gag aag cct  aaa tat caa ata aat  aat atc agc aca        5302
Ile  His Ala Glu Lys Pro  Lys Tyr Gln Ile Asn  Asn Ile Ser Thr            
1595                 1600                 1605                            

gtg  cct aaa gct att cct  gtg agt cct tca gct  gtg gaa gag gat        5347
Val  Pro Lys Ala Ile Pro  Val Ser Pro Ser Ala  Val Glu Glu Asp            
1610                 1615                 1620                            

gaa  gat gaa gat ggt cat  act gtg gtg gcc aca  gcc cga ggc ata        5392
Glu  Asp Glu Asp Gly His  Thr Val Val Ala Thr  Ala Arg Gly Ile            
1625                 1630                 1635                            

ttt  aac agc aat ggg ggc  gtg ctg agt tcc ata  gaa act ggt gtt        5437
Phe  Asn Ser Asn Gly Gly  Val Leu Ser Ser Ile  Glu Thr Gly Val            
1640                 1645                 1650                            

agt  ata att atc cct caa  gga gcc att ccc gaa  gga gtt gag cag        5482
Ser  Ile Ile Ile Pro Gln  Gly Ala Ile Pro Glu  Gly Val Glu Gln            
1655                 1660                 1665                            

gaa  atc tat ttc aag gtc  tgc cgg gac aac agc  atc ctt cca cct        5527
Glu  Ile Tyr Phe Lys Val  Cys Arg Asp Asn Ser  Ile Leu Pro Pro            
1670                 1675                 1680                            

tta  gat aaa gag aaa ggt  gaa aca ctg ctg agt  cct ttg gtg atg        5572
Leu  Asp Lys Glu Lys Gly  Glu Thr Leu Leu Ser  Pro Leu Val Met            
1685                 1690                 1695                            

tgt  ggt ccc cat ggc ctc  aag ttc ctg aag cct  gtg gag ctg cgc        5617
Cys  Gly Pro His Gly Leu  Lys Phe Leu Lys Pro  Val Glu Leu Arg            
1700                 1705                 1710                            

tta  cca cac tgt gat cct  aaa acc tgg caa aac  aag tgt ctt ccc        5662
Leu  Pro His Cys Asp Pro  Lys Thr Trp Gln Asn  Lys Cys Leu Pro            
1715                 1720                 1725                            

gga  gat cca aat tat ctc  gtt gga gca aac tgt  gtt tct gtc ctt        5707
Gly  Asp Pro Asn Tyr Leu  Val Gly Ala Asn Cys  Val Ser Val Leu            
1730                 1735                 1740                            

att  gac cac ttt taa ctcttgaaat ataggaactt aaataatgtg aaactggatt      5762
Ile  Asp His Phe                                                          
1745                                                                      

aaacttaatc taaatggaac cactctatca agtattatac cttttttaga gttgatacta     5822

cagtttgtta gtatgaggca tttgtttgaa ctgataaaga tgagtgagca tgcccctgaa     5882

ccatggtcgg aaaacatgct acacactgca tgtttgtgat tgacgggact gttggtattg     5942

gctagaggtt caaagatatt ttgctttgtg atttttgtaa tttttttatc gtcactgctt     6002

aacttcacat attgatttcc gttaaaatac cagccagtaa atgggggtgc atttgaggtc     6062

tgttctttcc aaagtacact gtttcaaact ttactatggc cctggcctag catacgtaca     6122

cattttattt tattatgcat gaagtaatat gcacacattt tttaaatgca cctggaatat     6182

ataaccagtg ttgtggattt aacagaaatg tacagcaagg agatttacaa ctgggggagg     6242

gtgaagtgaa gacaatgact tactgtacat gaaaacacat ttttcttagg gaaggataca     6302

aaagcatgtg agactggttc catggcctct tcagatctct aacttcacca tattaccaca     6362

gacatactaa ccagcagaaa tgccttaccc tcatgttctt aattcttagc tcattctcct     6422

tgtgttacta agtttttatg gcttttgtgc attatctaga tactgtatca tgacaaagac     6482

tgagtacgtt gtgcatttgg tggtttcaga aatgtgttat cacccagaag aaaatagtgg     6542

tgtgatttgg ggatattttt ttcttttctt ttcttttctt tttttttttt tttgacaagg     6602

ggcagtggtg gttttctgtt ctttctggct atgcatttga aaattttgat gttttaagga     6662

tgcttgtaca taatgcgtgc ataccacttt tgttcttggt ttgtaaatta acttttataa     6722

actttacctt ttttatacat aaacaagacc acgtttctaa aggctacctt tgtattctct     6782

cctgtacctc ttgagccttg aactttgacc tctgcagcaa taaagcagcg tttctatgac     6842

acatgcaagg tcattttttt taagaaaaag gatgcacaga gttgttacat ttttaagtgc     6902

tgcatttaaa agatacagtt actcagaatt ctctagtttg attaaattct tgcaaagtat     6962

ccctactgta atttgtgata caatgctgtg ccctaaagtg tattttttta ctaatagaca     7022

atttattatg gcacatcagc acgatttctg tttagataat acaccactac attctgttaa     7082

tcattaggtg tgactgaatt tcttttgccg ttattaaaaa tctcaaattt ctaaatctcc     7142

aaaataaaac tttttaaaat aaa                                             7165


<210>  594
<211>  1748
<212>  PRT
<213>  Homo sapiens

<400>  594

Met Ser Ala Arg Ala Ala Ala Ala Lys Ser Thr Ala Met Glu Glu Thr 
1               5                   10                  15      


Ala Ile Trp Glu Gln His Thr Val Thr Leu His Arg Ala Pro Gly Phe 
            20                  25                  30          


Gly Phe Gly Ile Ala Ile Ser Gly Gly Arg Asp Asn Pro His Phe Gln 
        35                  40                  45              


Ser Gly Glu Thr Ser Ile Val Ile Ser Asp Val Leu Lys Gly Gly Pro 
    50                  55                  60                  


Ala Glu Gly Gln Leu Gln Glu Asn Asp Arg Val Ala Met Val Asn Gly 
65                  70                  75                  80  


Val Ser Met Asp Asn Val Glu His Ala Phe Ala Val Gln Gln Leu Arg 
                85                  90                  95      


Lys Ser Gly Lys Asn Ala Lys Ile Thr Ile Arg Arg Lys Lys Lys Val 
            100                 105                 110         


Gln Ile Pro Val Ser Arg Pro Asp Pro Glu Pro Val Ser Asp Asn Glu 
        115                 120                 125             


Glu Asp Ser Tyr Asp Glu Glu Ile His Asp Pro Arg Ser Gly Arg Ser 
    130                 135                 140                 


Gly Val Val Asn Arg Arg Ser Glu Lys Ile Trp Pro Arg Asp Arg Ser 
145                 150                 155                 160 


Ala Ser Arg Glu Arg Ser Leu Ser Pro Arg Ser Asp Arg Arg Ser Val 
                165                 170                 175     


Ala Ser Ser Gln Pro Ala Lys Pro Thr Lys Val Thr Leu Val Lys Ser 
            180                 185                 190         


Arg Lys Asn Glu Glu Tyr Gly Leu Arg Leu Ala Ser His Ile Phe Val 
        195                 200                 205             


Lys Glu Ile Ser Gln Asp Ser Leu Ala Ala Arg Asp Gly Asn Ile Gln 
    210                 215                 220                 


Glu Gly Asp Val Val Leu Lys Ile Asn Gly Thr Val Thr Glu Asn Met 
225                 230                 235                 240 


Ser Leu Thr Asp Ala Lys Thr Leu Ile Glu Arg Ser Lys Gly Lys Leu 
                245                 250                 255     


Lys Met Val Val Gln Arg Asp Glu Arg Ala Thr Leu Leu Asn Val Pro 
            260                 265                 270         


Asp Leu Ser Asp Ser Ile His Ser Ala Asn Ala Ser Glu Arg Asp Asp 
        275                 280                 285             


Ile Ser Glu Ile Gln Ser Leu Ala Ser Asp His Ser Gly Arg Ser His 
    290                 295                 300                 


Asp Arg Pro Pro Arg Arg Ser Arg Ser Arg Ser Pro Asp Gln Arg Ser 
305                 310                 315                 320 


Glu Pro Ser Asp His Ser Arg His Ser Pro Gln Gln Pro Ser Asn Gly 
                325                 330                 335     


Ser Leu Arg Ser Arg Asp Glu Glu Arg Ile Ser Lys Pro Gly Ala Val 
            340                 345                 350         


Ser Thr Pro Val Lys His Ala Asp Asp His Thr Pro Lys Thr Val Glu 
        355                 360                 365             


Glu Val Thr Val Glu Arg Asn Glu Lys Gln Thr Pro Ser Leu Pro Glu 
    370                 375                 380                 


Pro Lys Pro Val Tyr Ala Gln Val Gly Gln Pro Asp Val Asp Leu Pro 
385                 390                 395                 400 


Val Ser Pro Ser Asp Gly Val Leu Pro Asn Ser Thr His Glu Asp Gly 
                405                 410                 415     


Ile Leu Arg Pro Ser Met Lys Leu Val Lys Phe Arg Lys Gly Asp Ser 
            420                 425                 430         


Val Gly Leu Arg Leu Ala Gly Gly Asn Asp Val Gly Ile Phe Val Ala 
        435                 440                 445             


Gly Val Leu Glu Asp Ser Pro Ala Ala Lys Glu Gly Leu Glu Glu Gly 
    450                 455                 460                 


Asp Gln Ile Leu Arg Val Asn Asn Val Asp Phe Thr Asn Ile Ile Arg 
465                 470                 475                 480 


Glu Glu Ala Val Leu Phe Leu Leu Asp Leu Pro Lys Gly Glu Glu Val 
                485                 490                 495     


Thr Ile Leu Ala Gln Lys Lys Lys Asp Val Tyr Arg Arg Ile Val Glu 
            500                 505                 510         


Ser Asp Val Gly Asp Ser Phe Tyr Ile Arg Thr His Phe Glu Tyr Glu 
        515                 520                 525             


Lys Glu Ser Pro Tyr Gly Leu Ser Phe Asn Lys Gly Glu Val Phe Arg 
    530                 535                 540                 


Val Val Asp Thr Leu Tyr Asn Gly Lys Leu Gly Ser Trp Leu Ala Ile 
545                 550                 555                 560 


Arg Ile Gly Lys Asn His Lys Glu Val Glu Arg Gly Ile Ile Pro Asn 
                565                 570                 575     


Lys Asn Arg Ala Glu Gln Leu Ala Ser Val Gln Tyr Thr Leu Pro Lys 
            580                 585                 590         


Thr Ala Gly Gly Asp Arg Ala Asp Phe Trp Arg Phe Arg Gly Leu Arg 
        595                 600                 605             


Ser Ser Lys Arg Asn Leu Arg Lys Ser Arg Glu Asp Leu Ser Ala Gln 
    610                 615                 620                 


Pro Val Gln Thr Lys Phe Pro Ala Tyr Glu Arg Val Val Leu Arg Glu 
625                 630                 635                 640 


Ala Gly Phe Leu Arg Pro Val Thr Ile Phe Gly Pro Ile Ala Asp Val 
                645                 650                 655     


Ala Arg Glu Lys Leu Ala Arg Glu Glu Pro Asp Ile Tyr Gln Ile Ala 
            660                 665                 670         


Lys Ser Glu Pro Arg Asp Ala Gly Thr Asp Gln Arg Ser Ser Gly Ile 
        675                 680                 685             


Ile Arg Leu His Thr Ile Lys Gln Ile Ile Asp Gln Asp Lys His Ala 
    690                 695                 700                 


Leu Leu Asp Val Thr Pro Asn Ala Val Asp Arg Leu Asn Tyr Ala Gln 
705                 710                 715                 720 


Trp Tyr Pro Ile Val Val Phe Leu Asn Pro Asp Ser Lys Gln Gly Val 
                725                 730                 735     


Lys Thr Met Arg Met Arg Leu Cys Pro Glu Ser Arg Lys Ser Ala Arg 
            740                 745                 750         


Lys Leu Tyr Glu Arg Ser His Lys Leu Arg Lys Asn Asn His His Leu 
        755                 760                 765             


Phe Thr Thr Thr Ile Asn Leu Asn Ser Met Asn Asp Gly Trp Tyr Gly 
    770                 775                 780                 


Ala Leu Lys Glu Ala Ile Gln Gln Gln Gln Asn Gln Leu Val Trp Val 
785                 790                 795                 800 


Ser Glu Gly Lys Ala Asp Gly Ala Thr Ser Asp Asp Leu Asp Leu His 
                805                 810                 815     


Asp Asp Arg Leu Ser Tyr Leu Ser Ala Pro Gly Ser Glu Tyr Ser Met 
            820                 825                 830         


Tyr Ser Thr Asp Ser Arg His Thr Ser Asp Tyr Glu Asp Thr Asp Thr 
        835                 840                 845             


Glu Gly Gly Ala Tyr Thr Asp Gln Glu Leu Asp Glu Thr Leu Asn Asp 
    850                 855                 860                 


Glu Val Gly Thr Pro Pro Glu Ser Ala Ile Thr Arg Ser Ser Glu Pro 
865                 870                 875                 880 


Val Arg Glu Asp Ser Ser Gly Met His His Glu Asn Gln Thr Tyr Pro 
                885                 890                 895     


Pro Tyr Ser Pro Gln Ala Gln Pro Gln Pro Ile His Arg Ile Asp Ser 
            900                 905                 910         


Pro Gly Phe Lys Pro Ala Ser Gln Gln Lys Ala Glu Ala Ser Ser Pro 
        915                 920                 925             


Val Pro Tyr Leu Ser Pro Glu Thr Asn Pro Ala Ser Ser Thr Ser Ala 
    930                 935                 940                 


Val Asn His Asn Val Asn Leu Thr Asn Val Arg Leu Glu Glu Pro Thr 
945                 950                 955                 960 


Pro Ala Pro Ser Thr Ser Tyr Ser Pro Gln Ala Asp Ser Leu Arg Thr 
                965                 970                 975     


Pro Ser Thr Glu Ala Ala His Ile Met Leu Arg Asp Gln Glu Pro Ser 
            980                 985                 990         


Leu Ser Ser His Val Asp Pro Thr  Lys Val Tyr Arg Lys  Asp Pro Tyr 
        995                 1000                 1005             


Pro Glu  Glu Met Met Arg Gln  Asn His Val Leu Lys  Gln Pro Ala 
    1010                 1015                 1020             


Val Ser  His Pro Gly His Arg  Pro Asp Lys Glu Pro  Asn Leu Thr 
    1025                 1030                 1035             


Tyr Glu  Pro Gln Leu Pro Tyr  Val Glu Lys Gln Ala  Ser Arg Asp 
    1040                 1045                 1050             


Leu Glu  Gln Pro Thr Tyr Arg  Tyr Glu Ser Ser Ser  Tyr Thr Asp 
    1055                 1060                 1065             


Gln Phe  Ser Arg Asn Tyr Glu  His Arg Leu Arg Tyr  Glu Asp Arg 
    1070                 1075                 1080             


Val Pro  Met Tyr Glu Glu Gln  Trp Ser Tyr Tyr Asp  Asp Lys Gln 
    1085                 1090                 1095             


Pro Tyr  Pro Ser Arg Pro Pro  Phe Asp Asn Gln His  Ser Gln Asp 
    1100                 1105                 1110             


Leu Asp  Ser Arg Gln His Pro  Glu Glu Ser Ser Glu  Arg Gly Tyr 
    1115                 1120                 1125             


Phe Pro  Arg Phe Glu Glu Pro  Ala Pro Leu Ser Tyr  Asp Ser Arg 
    1130                 1135                 1140             


Pro Arg  Tyr Glu Gln Ala Pro  Arg Ala Ser Ala Leu  Arg His Glu 
    1145                 1150                 1155             


Glu Gln  Pro Ala Pro Gly Tyr  Asp Thr His Gly Arg  Leu Arg Pro 
    1160                 1165                 1170             


Glu Ala  Gln Pro His Pro Ser  Ala Gly Pro Lys Pro  Ala Glu Ser 
    1175                 1180                 1185             


Lys Gln  Tyr Phe Glu Gln Tyr  Ser Arg Ser Tyr Glu  Gln Val Pro 
    1190                 1195                 1200             


Pro Gln  Gly Phe Thr Ser Arg  Ala Gly His Phe Glu  Pro Leu His 
    1205                 1210                 1215             


Gly Ala  Ala Ala Val Pro Pro  Leu Ile Pro Ser Ser  Gln His Lys 
    1220                 1225                 1230             


Pro Glu  Ala Leu Pro Ser Asn  Thr Lys Pro Leu Pro  Pro Pro Pro 
    1235                 1240                 1245             


Thr Gln  Thr Glu Glu Glu Glu  Asp Pro Ala Met Lys  Pro Gln Ser 
    1250                 1255                 1260             


Val Leu  Thr Arg Val Lys Met  Phe Glu Asn Lys Arg  Ser Ala Ser 
    1265                 1270                 1275             


Leu Glu  Thr Lys Lys Asp Val  Asn Asp Thr Gly Ser  Phe Lys Pro 
    1280                 1285                 1290             


Pro Glu  Val Ala Ser Lys Pro  Ser Gly Ala Pro Ile  Ile Gly Pro 
    1295                 1300                 1305             


Lys Pro  Thr Ser Gln Asn Gln  Phe Ser Glu His Asp  Lys Thr Leu 
    1310                 1315                 1320             


Tyr Arg  Ile Pro Glu Pro Gln  Lys Pro Gln Leu Lys  Pro Pro Glu 
    1325                 1330                 1335             


Asp Ile  Val Arg Ser Asn His  Tyr Asp Pro Glu Glu  Asp Glu Glu 
    1340                 1345                 1350             


Tyr Tyr  Arg Lys Gln Leu Ser  Tyr Phe Asp Arg Arg  Ser Phe Glu 
    1355                 1360                 1365             


Asn Lys  Pro Pro Ala His Ile  Ala Ala Ser His Leu  Ser Glu Pro 
    1370                 1375                 1380             


Ala Lys  Pro Ala His Ser Gln  Asn Gln Ser Asn Phe  Ser Ser Tyr 
    1385                 1390                 1395             


Ser Ser  Lys Gly Lys Pro Pro  Glu Ala Asp Gly Val  Asp Arg Ser 
    1400                 1405                 1410             


Phe Gly  Glu Lys Arg Tyr Glu  Pro Ile Gln Ala Thr  Pro Pro Pro 
    1415                 1420                 1425             


Pro Pro  Leu Pro Ser Gln Tyr  Ala Gln Pro Ser Gln  Pro Val Thr 
    1430                 1435                 1440             


Ser Ala  Ser Leu His Ile His  Ser Lys Gly Ala His  Gly Glu Gly 
    1445                 1450                 1455             


Asn Ser  Val Ser Leu Asp Phe  Gln Asn Ser Leu Val  Ser Lys Pro 
    1460                 1465                 1470             


Asp Pro  Pro Pro Ser Gln Asn  Lys Pro Ala Thr Phe  Arg Pro Pro 
    1475                 1480                 1485             


Asn Arg  Glu Asp Thr Ala Gln  Ala Ala Phe Tyr Pro  Gln Lys Ser 
    1490                 1495                 1500             


Phe Pro  Asp Lys Ala Pro Val  Asn Gly Thr Glu Gln  Thr Gln Lys 
    1505                 1510                 1515             


Thr Val  Thr Pro Ala Tyr Asn  Arg Phe Thr Pro Lys  Pro Tyr Thr 
    1520                 1525                 1530             


Ser Ser  Ala Arg Pro Phe Glu  Arg Lys Phe Glu Ser  Pro Lys Phe 
    1535                 1540                 1545             


Asn His  Asn Leu Leu Pro Ser  Glu Thr Ala His Lys  Pro Asp Leu 
    1550                 1555                 1560             


Ser Ser  Lys Thr Pro Thr Ser  Pro Lys Thr Leu Val  Lys Ser His 
    1565                 1570                 1575             


Ser Leu  Ala Gln Pro Pro Glu  Phe Asp Ser Gly Val  Glu Thr Phe 
    1580                 1585                 1590             


Ser Ile  His Ala Glu Lys Pro  Lys Tyr Gln Ile Asn  Asn Ile Ser 
    1595                 1600                 1605             


Thr Val  Pro Lys Ala Ile Pro  Val Ser Pro Ser Ala  Val Glu Glu 
    1610                 1615                 1620             


Asp Glu  Asp Glu Asp Gly His  Thr Val Val Ala Thr  Ala Arg Gly 
    1625                 1630                 1635             


Ile Phe  Asn Ser Asn Gly Gly  Val Leu Ser Ser Ile  Glu Thr Gly 
    1640                 1645                 1650             


Val Ser  Ile Ile Ile Pro Gln  Gly Ala Ile Pro Glu  Gly Val Glu 
    1655                 1660                 1665             


Gln Glu  Ile Tyr Phe Lys Val  Cys Arg Asp Asn Ser  Ile Leu Pro 
    1670                 1675                 1680             


Pro Leu  Asp Lys Glu Lys Gly  Glu Thr Leu Leu Ser  Pro Leu Val 
    1685                 1690                 1695             


Met Cys  Gly Pro His Gly Leu  Lys Phe Leu Lys Pro  Val Glu Leu 
    1700                 1705                 1710             


Arg Leu  Pro His Cys Asp Pro  Lys Thr Trp Gln Asn  Lys Cys Leu 
    1715                 1720                 1725             


Pro Gly  Asp Pro Asn Tyr Leu  Val Gly Ala Asn Cys  Val Ser Val 
    1730                 1735                 1740             


Leu Ile  Asp His Phe 
    1745             


<210>  595
<211>  781
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(627)

<400>  595
atg ctt tct gtg gac acc act gag ctc tgc ctc aac tcc acc ctc tgc         48
Met Leu Ser Val Asp Thr Thr Glu Leu Cys Leu Asn Ser Thr Leu Cys           
1               5                   10                  15                

gac cgg agg act atg ccc cta ctc ccg gaa gcc ctc gga caa gga act         96
Asp Arg Arg Thr Met Pro Leu Leu Pro Glu Ala Leu Gly Gln Gly Thr           
            20                  25                  30                    

gta gcc cat gta ccg cgt gac gtg aga gcg gag ccc ggg tct gcc cgg        144
Val Ala His Val Pro Arg Asp Val Arg Ala Glu Pro Gly Ser Ala Arg           
        35                  40                  45                        

gcg cgg gcc cgc ggc cac ggc gtt tgg atc cca gat ccc agc ccc cgc        192
Ala Arg Ala Arg Gly His Gly Val Trp Ile Pro Asp Pro Ser Pro Arg           
    50                  55                  60                            

gct cag tcc ggg ctt cct gac cgg cgc tct ccg cgt ccc ttc tcg cgc        240
Ala Gln Ser Gly Leu Pro Asp Arg Arg Ser Pro Arg Pro Phe Ser Arg           
65                  70                  75                  80            

gcc ctt acc tgg ggc tgg gga ggt ggg gac aga gcc ggg cgc agt cgg        288
Ala Leu Thr Trp Gly Trp Gly Gly Gly Asp Arg Ala Gly Arg Ser Arg           
                85                  90                  95                

ggg cac agc cct gag gcg ggg ctg agg gcc agg ccg cca cgt ccc tgg        336
Gly His Ser Pro Glu Ala Gly Leu Arg Ala Arg Pro Pro Arg Pro Trp           
            100                 105                 110                   

acc ctg aaa acg ggc tcg gac ccc cgc tgc agc gtg gac tcc ggt gtg        384
Thr Leu Lys Thr Gly Ser Asp Pro Arg Cys Ser Val Asp Ser Gly Val           
        115                 120                 125                       

gcc gcg ggg cgt gca acc cgg acc ctg gcc agc tcc gtg tcc tcc aga        432
Ala Ala Gly Arg Ala Thr Arg Thr Leu Ala Ser Ser Val Ser Ser Arg           
    130                 135                 140                           

cct tta ctc atg tcc ccg cat cgc cag gcc gag ctg cac ctt cgg tcc        480
Pro Leu Leu Met Ser Pro His Arg Gln Ala Glu Leu His Leu Arg Ser           
145                 150                 155                 160           

ccg ccc gcg gca gcc gag gag agg aga gca agg ccc aga ccg ggg agg        528
Pro Pro Ala Ala Ala Glu Glu Arg Arg Ala Arg Pro Arg Pro Gly Arg           
                165                 170                 175               

aac cca cac agc ctc tgt gct cca gcc tgc ttg aaa gac aag gtc tac        576
Asn Pro His Ser Leu Cys Ala Pro Ala Cys Leu Lys Asp Lys Val Tyr           
            180                 185                 190                   

cta caa cgc aga gat gca cac att aag gac aat gaa aca ccc aag tgt        624
Leu Gln Arg Arg Asp Ala His Ile Lys Asp Asn Glu Thr Pro Lys Cys           
        195                 200                 205                       

tag gaaccagaat aatcagccct aatagagggg aggctgatca gggagggcct             677

cctggaggag gaggcacaac atcagggtgc actgtgattt ctggagaccc aaggagttct      737

ggtaaatgac aggtgagaaa aagaaaatgt aataaaatat aatt                       781


<210>  596
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  596

Met Leu Ser Val Asp Thr Thr Glu Leu Cys Leu Asn Ser Thr Leu Cys 
1               5                   10                  15      


Asp Arg Arg Thr Met Pro Leu Leu Pro Glu Ala Leu Gly Gln Gly Thr 
            20                  25                  30          


Val Ala His Val Pro Arg Asp Val Arg Ala Glu Pro Gly Ser Ala Arg 
        35                  40                  45              


Ala Arg Ala Arg Gly His Gly Val Trp Ile Pro Asp Pro Ser Pro Arg 
    50                  55                  60                  


Ala Gln Ser Gly Leu Pro Asp Arg Arg Ser Pro Arg Pro Phe Ser Arg 
65                  70                  75                  80  


Ala Leu Thr Trp Gly Trp Gly Gly Gly Asp Arg Ala Gly Arg Ser Arg 
                85                  90                  95      


Gly His Ser Pro Glu Ala Gly Leu Arg Ala Arg Pro Pro Arg Pro Trp 
            100                 105                 110         


Thr Leu Lys Thr Gly Ser Asp Pro Arg Cys Ser Val Asp Ser Gly Val 
        115                 120                 125             


Ala Ala Gly Arg Ala Thr Arg Thr Leu Ala Ser Ser Val Ser Ser Arg 
    130                 135                 140                 


Pro Leu Leu Met Ser Pro His Arg Gln Ala Glu Leu His Leu Arg Ser 
145                 150                 155                 160 


Pro Pro Ala Ala Ala Glu Glu Arg Arg Ala Arg Pro Arg Pro Gly Arg 
                165                 170                 175     


Asn Pro His Ser Leu Cys Ala Pro Ala Cys Leu Lys Asp Lys Val Tyr 
            180                 185                 190         


Leu Gln Arg Arg Asp Ala His Ile Lys Asp Asn Glu Thr Pro Lys Cys 
        195                 200                 205             


<210>  597
<211>  2489
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (239)..(955)

<400>  597
agtctcttca gttccttccg cgtcgtttct tggctgtttc cgcccagctc ctttgtgccg       60

cgcagaacaa cgagatgacg catgcgcaaa gcgcagcggc cgcatatata aacgcgaacc      120

cgggctcttc ctcgtagtgc cgccgggact cttggcgggt gaaggtgtgt gtcagctttt      180

gcgtcactcg agccctgggc gctgcttgct aaagagccga gcacgcgggt ctgtcatc        238

atg tcg cgt tac ggg cgg tac gga gga gaa acc aag gtg tat gtt ggt        286
Met Ser Arg Tyr Gly Arg Tyr Gly Gly Glu Thr Lys Val Tyr Val Gly           
1               5                   10                  15                

aac ctg gga act ggc gct ggc aaa gga gag tta gaa agg gct ttc agt        334
Asn Leu Gly Thr Gly Ala Gly Lys Gly Glu Leu Glu Arg Ala Phe Ser           
            20                  25                  30                    

tat tat ggt cct tta aga act gta tgg att gcg aga aat cct cca gga        382
Tyr Tyr Gly Pro Leu Arg Thr Val Trp Ile Ala Arg Asn Pro Pro Gly           
        35                  40                  45                        

ttt gcc ttt gtg gaa ttc gaa gat cct aga gat gca gaa gat gca gta        430
Phe Ala Phe Val Glu Phe Glu Asp Pro Arg Asp Ala Glu Asp Ala Val           
    50                  55                  60                            

cga gga ctg gat gga aag gtg att tgt ggc tcc cga gtg agg gtt gaa        478
Arg Gly Leu Asp Gly Lys Val Ile Cys Gly Ser Arg Val Arg Val Glu           
65                  70                  75                  80            

cta tcg aca ggc atg cct cgg aga tca cgt ttt gat aga cca cct gcc        526
Leu Ser Thr Gly Met Pro Arg Arg Ser Arg Phe Asp Arg Pro Pro Ala           
                85                  90                  95                

cga cgt ccc ttt gat cca aat gat aga tgc tat gag tgt ggc gaa aag        574
Arg Arg Pro Phe Asp Pro Asn Asp Arg Cys Tyr Glu Cys Gly Glu Lys           
            100                 105                 110                   

gga cat tat gct tat gat tgt cat cgt tac agc cgg cga aga aga agc        622
Gly His Tyr Ala Tyr Asp Cys His Arg Tyr Ser Arg Arg Arg Arg Ser           
        115                 120                 125                       

agg tca cgg tct aga tca cat tct cga tcc aga gga agg cga tac tct        670
Arg Ser Arg Ser Arg Ser His Ser Arg Ser Arg Gly Arg Arg Tyr Ser           
    130                 135                 140                           

cgc tca cgc agc agg agc agg gga cga agg tca agg tca gca tct cct        718
Arg Ser Arg Ser Arg Ser Arg Gly Arg Arg Ser Arg Ser Ala Ser Pro           
145                 150                 155                 160           

cga cga tca aga tct atc tct ctt cgt aga tca aga tca gct tca ctc        766
Arg Arg Ser Arg Ser Ile Ser Leu Arg Arg Ser Arg Ser Ala Ser Leu           
                165                 170                 175               

aga aga tct agg tct ggt tct ata aaa gga tcg agg tat ttc caa tcc        814
Arg Arg Ser Arg Ser Gly Ser Ile Lys Gly Ser Arg Tyr Phe Gln Ser           
            180                 185                 190                   

ccg tcg agg tca aga tca aga tcc agg tct att tca cga cca aga agc        862
Pro Ser Arg Ser Arg Ser Arg Ser Arg Ser Ile Ser Arg Pro Arg Ser           
        195                 200                 205                       

agc cga tca aag tcc aga tct cca tct cca aaa aga agt cgt tcc cca        910
Ser Arg Ser Lys Ser Arg Ser Pro Ser Pro Lys Arg Ser Arg Ser Pro           
    210                 215                 220                           

tca gga agt cct cgc aga agt gca agt cct gaa aga atg gac tga            955
Ser Gly Ser Pro Arg Arg Ser Ala Ser Pro Glu Arg Met Asp                   
225                 230                 235                               

agctctcaag ttcacccttt agggaaaagt tattttgttt acattattat aagggatttg     1015

tgatgtctgt aaagtgtaac ctaggaaaga taattcaacc atctaatcaa aatggatctg     1075

gattactatg taaattcaca gcagtaagat aatataaatt ttgttgaatg tattaacatc     1135

atatggtctg aaaatgtggg tttttatttg gcacatttaa ataaaatgtt tctaactaga     1195

tttttgattt gtgttcaata ttaacacttc ttaatttgat atatttgaga gtcagacatt     1255

ataattgtta accttattca tacataccta cattcagaat tgaaaggtgt tggttaagtc     1315

ttgaacatca ctattctatg cataaaactt ggccaggatc ttaagggact ttgaaaattc     1375

catcttaccc ttgtagctct gggtaagatg acctgagtcc cttatgatac agcctgaatg     1435

catcatgaca gatccttaag ttagctaatc cgtttgaagt tggtgttagt aggtattgta     1495

tgatcagtgg tgaagcaagt aggaccactg atgtgtctaa atgagcatga caggaactaa     1555

acgaaactga ttaaatgtat gagaaataga aacatttctg gatgatcttt atactaattg     1615

cagctttcag gctactaggt ggcatagtgt taattaggac tccccaagat atggggagtt     1675

ctactctcaa tggtcttgtt tctttgcttt ctacattagt taaccagttt tataccaaaa     1735

aatgcatgtt tgaggaattg tctgaaattg ggacaaaaca ccttcatgta aaccagcttt     1795

gcaaaatttt ccagcccaga tactcttcat ctattcaaat ggattgtctt attctgagca     1855

aagacctgtt gttaatcttc aagctaggtt ttgcagttcc caaccacaac attcttctat     1915

tttgccaggc tggtgcaaag taattaaaga tgtcaatcag aaatgtcaat gagactaaag     1975

tggttttgta aatctcagct atatttagca acactccatg tagctaatat tttttggtag     2035

catctggtag accttagaat gttacatagc cagtaggttc tttattcaaa ttttaagtat     2095

cttaagaata gtagggcagt aacagttact tttgagagtt ttctggtcaa gcttttacca     2155

ggcattctct agccttggta caaaaaaaaa aaaacctgct ggttgcgcag atacctaggc     2215

ttgtccattt tatgcatttc agcaaagtca ttggatacta ttgcaacttg ggaatactgg     2275

tctgcatcaa gtttattcgg tagtttgacc gctagtatgt tggaagttat ttggattgtt     2335

tttggaattt tgactggctg aattatggtt ggtataaagt tatgtgtata actggcaggc     2395

ttatttatct gttgcacttg gttagcttta attgttctgt attatttaaa gataagttta     2455

ctcaacaata aatctgcaga gattgaacaa ataa                                 2489


<210>  598
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  598

Met Ser Arg Tyr Gly Arg Tyr Gly Gly Glu Thr Lys Val Tyr Val Gly 
1               5                   10                  15      


Asn Leu Gly Thr Gly Ala Gly Lys Gly Glu Leu Glu Arg Ala Phe Ser 
            20                  25                  30          


Tyr Tyr Gly Pro Leu Arg Thr Val Trp Ile Ala Arg Asn Pro Pro Gly 
        35                  40                  45              


Phe Ala Phe Val Glu Phe Glu Asp Pro Arg Asp Ala Glu Asp Ala Val 
    50                  55                  60                  


Arg Gly Leu Asp Gly Lys Val Ile Cys Gly Ser Arg Val Arg Val Glu 
65                  70                  75                  80  


Leu Ser Thr Gly Met Pro Arg Arg Ser Arg Phe Asp Arg Pro Pro Ala 
                85                  90                  95      


Arg Arg Pro Phe Asp Pro Asn Asp Arg Cys Tyr Glu Cys Gly Glu Lys 
            100                 105                 110         


Gly His Tyr Ala Tyr Asp Cys His Arg Tyr Ser Arg Arg Arg Arg Ser 
        115                 120                 125             


Arg Ser Arg Ser Arg Ser His Ser Arg Ser Arg Gly Arg Arg Tyr Ser 
    130                 135                 140                 


Arg Ser Arg Ser Arg Ser Arg Gly Arg Arg Ser Arg Ser Ala Ser Pro 
145                 150                 155                 160 


Arg Arg Ser Arg Ser Ile Ser Leu Arg Arg Ser Arg Ser Ala Ser Leu 
                165                 170                 175     


Arg Arg Ser Arg Ser Gly Ser Ile Lys Gly Ser Arg Tyr Phe Gln Ser 
            180                 185                 190         


Pro Ser Arg Ser Arg Ser Arg Ser Arg Ser Ile Ser Arg Pro Arg Ser 
        195                 200                 205             


Ser Arg Ser Lys Ser Arg Ser Pro Ser Pro Lys Arg Ser Arg Ser Pro 
    210                 215                 220                 


Ser Gly Ser Pro Arg Arg Ser Ala Ser Pro Glu Arg Met Asp 
225                 230                 235             


<210>  599
<211>  1784
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (112)..(1500)

<400>  599
cgggattacc gagggggtgc gggatgctga tgctgaactg gccaagctgg gagggaagaa       60

gaaagggagg ggaggggaga atcgaggacg gacggcctag ccaggccaag a atg caa       117
                                                         Met Gln          
                                                         1                

ttg ccc cgg tgg tgg gag ctg gga gac ccc tgt gct tgg acg gga cag        165
Leu Pro Arg Trp Trp Glu Leu Gly Asp Pro Cys Ala Trp Thr Gly Gln           
        5                   10                  15                        

ggt cgg ggg aca cgc agg atg agc ccc gcg acc act ggc aca ttc ttg        213
Gly Arg Gly Thr Arg Arg Met Ser Pro Ala Thr Thr Gly Thr Phe Leu           
    20                  25                  30                            

ctg aca gtg tac agt att ttc tcc aag gta cac tcc gat cgg aat gta        261
Leu Thr Val Tyr Ser Ile Phe Ser Lys Val His Ser Asp Arg Asn Val           
35                  40                  45                  50            

tac cca tca gca ggt gtc ctc ttt gtt cat gtt ttg gaa aga gaa tat        309
Tyr Pro Ser Ala Gly Val Leu Phe Val His Val Leu Glu Arg Glu Tyr           
                55                  60                  65                

ttt aag ggg gaa ttt cca cct tac cca aaa cct ggc gag att agt aat        357
Phe Lys Gly Glu Phe Pro Pro Tyr Pro Lys Pro Gly Glu Ile Ser Asn           
            70                  75                  80                    

gat ccc ata aca ttt aat aca aat tta atg ggt tac cca gac cga cct        405
Asp Pro Ile Thr Phe Asn Thr Asn Leu Met Gly Tyr Pro Asp Arg Pro           
        85                  90                  95                        

gga tgg ctt cga tat atc caa agg aca cca tat agt gat gga gtc cta        453
Gly Trp Leu Arg Tyr Ile Gln Arg Thr Pro Tyr Ser Asp Gly Val Leu           
    100                 105                 110                           

tat ggg tcc cca aca gct gaa aat gtg ggg aag cca aca atc att gag        501
Tyr Gly Ser Pro Thr Ala Glu Asn Val Gly Lys Pro Thr Ile Ile Glu           
115                 120                 125                 130           

ata act gcc tac aac agg cgc acc ttt gag act gca agg cat aat ttg        549
Ile Thr Ala Tyr Asn Arg Arg Thr Phe Glu Thr Ala Arg His Asn Leu           
                135                 140                 145               

ata att aat ata atg tct gca gaa gac ttc ccg ttg cca tat caa gca        597
Ile Ile Asn Ile Met Ser Ala Glu Asp Phe Pro Leu Pro Tyr Gln Ala           
            150                 155                 160                   

gaa ttc ttc att aag aat atg aat gta gaa gaa atg ttg gcc agt gag        645
Glu Phe Phe Ile Lys Asn Met Asn Val Glu Glu Met Leu Ala Ser Glu           
        165                 170                 175                       

gtt ctt gga gac ttt ctt ggc gca gtg aaa aat gtg tgg cag cca gag        693
Val Leu Gly Asp Phe Leu Gly Ala Val Lys Asn Val Trp Gln Pro Glu           
    180                 185                 190                           

cgc ctg aac gcc ata aac atc aca tcg gcc cta gac agg ggt ggc agg        741
Arg Leu Asn Ala Ile Asn Ile Thr Ser Ala Leu Asp Arg Gly Gly Arg           
195                 200                 205                 210           

gtg cca ctt ccc att aat gac ctg aag gag ggc gtt tat gtc atg gtt        789
Val Pro Leu Pro Ile Asn Asp Leu Lys Glu Gly Val Tyr Val Met Val           
                215                 220                 225               

ggt gca gat gtc ccg ttt tct tct tgt tta cga gaa gtt gaa aat cca        837
Gly Ala Asp Val Pro Phe Ser Ser Cys Leu Arg Glu Val Glu Asn Pro           
            230                 235                 240                   

cag aat caa ttg aga tgt agt caa gaa atg gag cct gta ata aca tgt        885
Gln Asn Gln Leu Arg Cys Ser Gln Glu Met Glu Pro Val Ile Thr Cys           
        245                 250                 255                       

gat aaa aaa ttt cgt act caa ttt tac att gac tgg tgc aaa att tca        933
Asp Lys Lys Phe Arg Thr Gln Phe Tyr Ile Asp Trp Cys Lys Ile Ser           
    260                 265                 270                           

ttg gtt gat aaa aca aag caa gtg tcc acc tat cag gaa gtg att cgt        981
Leu Val Asp Lys Thr Lys Gln Val Ser Thr Tyr Gln Glu Val Ile Arg           
275                 280                 285                 290           

gga gag ggg att tta cct gat ggt gga gaa tac aaa ccc cct tct gat       1029
Gly Glu Gly Ile Leu Pro Asp Gly Gly Glu Tyr Lys Pro Pro Ser Asp           
                295                 300                 305               

tct ttg aaa agc aga gac tat tac acg gat ttc cta att aca ctg gct       1077
Ser Leu Lys Ser Arg Asp Tyr Tyr Thr Asp Phe Leu Ile Thr Leu Ala           
            310                 315                 320                   

gtg ccc tcg gca gtg gca ctg gtc ctt ttt cta ata ctt gct tat atc       1125
Val Pro Ser Ala Val Ala Leu Val Leu Phe Leu Ile Leu Ala Tyr Ile           
        325                 330                 335                       

atg tgc tgc cga cgg gaa ggc gtg gaa aag aga aac atg caa aca cca       1173
Met Cys Cys Arg Arg Glu Gly Val Glu Lys Arg Asn Met Gln Thr Pro           
    340                 345                 350                           

gac atc caa ctg gtc cat cac agt gct att cag aaa tct acc aag gag       1221
Asp Ile Gln Leu Val His His Ser Ala Ile Gln Lys Ser Thr Lys Glu           
355                 360                 365                 370           

ctt cga gac atg tcc aag aat aga gag ata gca tgg ccc ctg tca acg       1269
Leu Arg Asp Met Ser Lys Asn Arg Glu Ile Ala Trp Pro Leu Ser Thr           
                375                 380                 385               

ctt cct gtg ttc cac cct gtg act ggg gaa atc ata cct cct tta cac       1317
Leu Pro Val Phe His Pro Val Thr Gly Glu Ile Ile Pro Pro Leu His           
            390                 395                 400                   

aca gac aac tat gat agc aca aac atg cca ttg atg caa acg cag caa       1365
Thr Asp Asn Tyr Asp Ser Thr Asn Met Pro Leu Met Gln Thr Gln Gln           
        405                 410                 415                       

tgg agt ttc gct cct gtt gcc cag gct gga gtg caa tgg agc gat ctt       1413
Trp Ser Phe Ala Pro Val Ala Gln Ala Gly Val Gln Trp Ser Asp Leu           
    420                 425                 430                           

ggc tca ctg cag cct ccg cct ccc agg aac ttg cca cat cag act cag       1461
Gly Ser Leu Gln Pro Pro Pro Pro Arg Asn Leu Pro His Gln Thr Gln           
435                 440                 445                 450           

att ccc caa cag cag act aca ggt aaa tgg tat ccc tga agaaagaaaa        1510
Ile Pro Gln Gln Gln Thr Thr Gly Lys Trp Tyr Pro                           
                455                 460                                   

ctgactgaag caatgaattt ataatcagac aatatagcag ttacatcaca tttcttttct     1570

cttccaataa tgcatgagct tttctggcat atgttatgca tgttggcagt attaagtgta     1630

taccaaataa tacaacataa ctttcatttt actaatgtat ttttttgtac ttaaagcatt     1690

tttgacaatt tgtaaaacat tgatgacttt atatttgtta caataaaagt tgatctttaa     1750

aataaatatt attaatgaag cctaaaaaaa aaaa                                 1784


<210>  600
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  600

Met Gln Leu Pro Arg Trp Trp Glu Leu Gly Asp Pro Cys Ala Trp Thr 
1               5                   10                  15      


Gly Gln Gly Arg Gly Thr Arg Arg Met Ser Pro Ala Thr Thr Gly Thr 
            20                  25                  30          


Phe Leu Leu Thr Val Tyr Ser Ile Phe Ser Lys Val His Ser Asp Arg 
        35                  40                  45              


Asn Val Tyr Pro Ser Ala Gly Val Leu Phe Val His Val Leu Glu Arg 
    50                  55                  60                  


Glu Tyr Phe Lys Gly Glu Phe Pro Pro Tyr Pro Lys Pro Gly Glu Ile 
65                  70                  75                  80  


Ser Asn Asp Pro Ile Thr Phe Asn Thr Asn Leu Met Gly Tyr Pro Asp 
                85                  90                  95      


Arg Pro Gly Trp Leu Arg Tyr Ile Gln Arg Thr Pro Tyr Ser Asp Gly 
            100                 105                 110         


Val Leu Tyr Gly Ser Pro Thr Ala Glu Asn Val Gly Lys Pro Thr Ile 
        115                 120                 125             


Ile Glu Ile Thr Ala Tyr Asn Arg Arg Thr Phe Glu Thr Ala Arg His 
    130                 135                 140                 


Asn Leu Ile Ile Asn Ile Met Ser Ala Glu Asp Phe Pro Leu Pro Tyr 
145                 150                 155                 160 


Gln Ala Glu Phe Phe Ile Lys Asn Met Asn Val Glu Glu Met Leu Ala 
                165                 170                 175     


Ser Glu Val Leu Gly Asp Phe Leu Gly Ala Val Lys Asn Val Trp Gln 
            180                 185                 190         


Pro Glu Arg Leu Asn Ala Ile Asn Ile Thr Ser Ala Leu Asp Arg Gly 
        195                 200                 205             


Gly Arg Val Pro Leu Pro Ile Asn Asp Leu Lys Glu Gly Val Tyr Val 
    210                 215                 220                 


Met Val Gly Ala Asp Val Pro Phe Ser Ser Cys Leu Arg Glu Val Glu 
225                 230                 235                 240 


Asn Pro Gln Asn Gln Leu Arg Cys Ser Gln Glu Met Glu Pro Val Ile 
                245                 250                 255     


Thr Cys Asp Lys Lys Phe Arg Thr Gln Phe Tyr Ile Asp Trp Cys Lys 
            260                 265                 270         


Ile Ser Leu Val Asp Lys Thr Lys Gln Val Ser Thr Tyr Gln Glu Val 
        275                 280                 285             


Ile Arg Gly Glu Gly Ile Leu Pro Asp Gly Gly Glu Tyr Lys Pro Pro 
    290                 295                 300                 


Ser Asp Ser Leu Lys Ser Arg Asp Tyr Tyr Thr Asp Phe Leu Ile Thr 
305                 310                 315                 320 


Leu Ala Val Pro Ser Ala Val Ala Leu Val Leu Phe Leu Ile Leu Ala 
                325                 330                 335     


Tyr Ile Met Cys Cys Arg Arg Glu Gly Val Glu Lys Arg Asn Met Gln 
            340                 345                 350         


Thr Pro Asp Ile Gln Leu Val His His Ser Ala Ile Gln Lys Ser Thr 
        355                 360                 365             


Lys Glu Leu Arg Asp Met Ser Lys Asn Arg Glu Ile Ala Trp Pro Leu 
    370                 375                 380                 


Ser Thr Leu Pro Val Phe His Pro Val Thr Gly Glu Ile Ile Pro Pro 
385                 390                 395                 400 


Leu His Thr Asp Asn Tyr Asp Ser Thr Asn Met Pro Leu Met Gln Thr 
                405                 410                 415     


Gln Gln Trp Ser Phe Ala Pro Val Ala Gln Ala Gly Val Gln Trp Ser 
            420                 425                 430         


Asp Leu Gly Ser Leu Gln Pro Pro Pro Pro Arg Asn Leu Pro His Gln 
        435                 440                 445             


Thr Gln Ile Pro Gln Gln Gln Thr Thr Gly Lys Trp Tyr Pro 
    450                 455                 460         


<210>  601
<211>  2126
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (189)..(863)

<400>  601
aatgatgctg atctgaagaa atgaataatg tgagcattag gggcggcagt gggattactc       60

agtgttgaga gaaacaacac ggaaagccca gagcagagga gggagaaggc cccattctct      120

cagctttaat ctactgcacc tcggagggca gagctctaac cagacacgct gcaagcatca      180

gaatcggg atg aac atc gag gtg ggg aac att tct tat aca gga gcc atc       230
         Met Asn Ile Glu Val Gly Asn Ile Ser Tyr Thr Gly Ala Ile          
         1               5                   10                           

atc tcc tgg tcg tcc tcg gag ccc tgc ctg gag gac tat tac cat att        278
Ile Ser Trp Ser Ser Ser Glu Pro Cys Leu Glu Asp Tyr Tyr His Ile           
15                  20                  25                  30            

atg tac agg ccc aac tgg aac agc atc ttc tct ggc tat ctt cgc tac        326
Met Tyr Arg Pro Asn Trp Asn Ser Ile Phe Ser Gly Tyr Leu Arg Tyr           
                35                  40                  45                

agc ttc cac cac gag gag aag gtg cct cga acg atc agc tcc gtg gtg        374
Ser Phe His His Glu Glu Lys Val Pro Arg Thr Ile Ser Ser Val Val           
            50                  55                  60                    

ctg gaa cat ctt gcc cct tcc act ctc tac ttc ctg tgc atc agc tgt        422
Leu Glu His Leu Ala Pro Ser Thr Leu Tyr Phe Leu Cys Ile Ser Cys           
        65                  70                  75                        

aag aag gct gcc ttc cct tac agg cac tac tgc acc atg ttc cac acc        470
Lys Lys Ala Ala Phe Pro Tyr Arg His Tyr Cys Thr Met Phe His Thr           
    80                  85                  90                            

ctg gat aag agt ccg ctg gct cct gga agc tcc ctg gta gac ccc cag        518
Leu Asp Lys Ser Pro Leu Ala Pro Gly Ser Ser Leu Val Asp Pro Gln           
95                  100                 105                 110           

atc tcc ctt tgg gtg ctg atg gcc att ctg ctg gcc tgc ttc aca gcc        566
Ile Ser Leu Trp Val Leu Met Ala Ile Leu Leu Ala Cys Phe Thr Ala           
                115                 120                 125               

gtc ttg gcc ttc atc tgc ctc cag ttc tgg tgt gtc cgt tgc cat gag        614
Val Leu Ala Phe Ile Cys Leu Gln Phe Trp Cys Val Arg Cys His Glu           
            130                 135                 140                   

ccg cga tgg tct tac agg gct ggc cac atg gag gag gcc aat ggg ttg        662
Pro Arg Trp Ser Tyr Arg Ala Gly His Met Glu Glu Ala Asn Gly Leu           
        145                 150                 155                       

gtg aga tgg cca gag gag gcc ccg gat ctt ggt cag agg gag gaa gac        710
Val Arg Trp Pro Glu Glu Ala Pro Asp Leu Gly Gln Arg Glu Glu Asp           
    160                 165                 170                           

ctg cag ggg ctc ccc ctg gtg gaa atg cca cgc aag aac tcc aga gat        758
Leu Gln Gly Leu Pro Leu Val Glu Met Pro Arg Lys Asn Ser Arg Asp           
175                 180                 185                 190           

gga gct gaa ctg gat ccc gaa gcc aac cag gat gcc cct gat gcg ggt        806
Gly Ala Glu Leu Asp Pro Glu Ala Asn Gln Asp Ala Pro Asp Ala Gly           
                195                 200                 205               

gcc tta cag agg ggg ggt ggt gac cca ccc gct ata ctg cct cat tgt        854
Ala Leu Gln Arg Gly Gly Gly Asp Pro Pro Ala Ile Leu Pro His Cys           
            210                 215                 220                   

ggg gaa tga gagtggggag gagagcgccc gcatcatgta gcctaaagct                903
Gly Glu                                                                   
                                                                          

ttccacacag taggtcgttt gtacaaatgt gtctatagac tacccatttc tctcccatca      963

aacgtcactg ctattgtagg tcacctgggt tggatgaatg ccccatgaca aagcttctca     1023

agctggaaaa tgtatccccc agggtatgcc aaggcacaaa cgaggcatct cagcagcagc     1083

gtccactcgg aggacacagt taagaattga aagcattgtt ttaacattaa aacaaacatg     1143

gatatgttat aaagtagaaa gcaaaaattt gcatgacaaa taaaacacag cacttgaagg     1203

aaacacttga gttacaagta ggctctcaga ggtacacttt tgggcaaagg tagatgtcca     1263

gtttcctctg cccttgaggg gattatttgg aaataatttg ggattatttg gaaataattt     1323

gtgagaaccc ttgctctgga gtgttttcca acttttaggc aatcacatac caccgctctc     1383

tattttttaa aaccatggat tatcttcact attattaata atactttcct ttaaattgac     1443

tcatttttta agcgtaaact tattttcaaa gacagcctta tattactcca taagtgaaaa     1503

accagcaccc tcctgctgca aacagaaggg aagagacata agaataaaca tcatgaaaac     1563

aagataatat taaataatct gacttagctt ctattgcctg ccagtgattc tgagcttaat     1623

gcctgcttgc ttgtctttga taaaaaggga gatccagtgt tggagaggta ataaagacat     1683

attagcacca atatttgtct ttctccttga tatagcataa ggtttgaaag agaatcgaaa     1743

agggaagtgc tgtttttact ttgcgagtca gtgttagtta aatgccatgt ctgtgaacca     1803

cctcaaatgc tgtcagtcag cttcccttga tttgagaaaa ttgtcttgac cagactaggc     1863

aggctgttct ggagaagacg cctgtactct ccaagcatca tccaagacct tcccagtacc     1923

ctcttatatc tatagagcac aaaatcccag aatcacagga cgacactgca gtgaatcaac     1983

taagaaacag caggagctga gaagccaaga cgagaagccc cacatcccta ttcccttgcc     2043

tacctcatgc attccctgct cggcacccag acttttgccc ccattcctgc tacttgtgaa     2103

caaataaaga ttcatatact cac                                             2126


<210>  602
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  602

Met Asn Ile Glu Val Gly Asn Ile Ser Tyr Thr Gly Ala Ile Ile Ser 
1               5                   10                  15      


Trp Ser Ser Ser Glu Pro Cys Leu Glu Asp Tyr Tyr His Ile Met Tyr 
            20                  25                  30          


Arg Pro Asn Trp Asn Ser Ile Phe Ser Gly Tyr Leu Arg Tyr Ser Phe 
        35                  40                  45              


His His Glu Glu Lys Val Pro Arg Thr Ile Ser Ser Val Val Leu Glu 
    50                  55                  60                  


His Leu Ala Pro Ser Thr Leu Tyr Phe Leu Cys Ile Ser Cys Lys Lys 
65                  70                  75                  80  


Ala Ala Phe Pro Tyr Arg His Tyr Cys Thr Met Phe His Thr Leu Asp 
                85                  90                  95      


Lys Ser Pro Leu Ala Pro Gly Ser Ser Leu Val Asp Pro Gln Ile Ser 
            100                 105                 110         


Leu Trp Val Leu Met Ala Ile Leu Leu Ala Cys Phe Thr Ala Val Leu 
        115                 120                 125             


Ala Phe Ile Cys Leu Gln Phe Trp Cys Val Arg Cys His Glu Pro Arg 
    130                 135                 140                 


Trp Ser Tyr Arg Ala Gly His Met Glu Glu Ala Asn Gly Leu Val Arg 
145                 150                 155                 160 


Trp Pro Glu Glu Ala Pro Asp Leu Gly Gln Arg Glu Glu Asp Leu Gln 
                165                 170                 175     


Gly Leu Pro Leu Val Glu Met Pro Arg Lys Asn Ser Arg Asp Gly Ala 
            180                 185                 190         


Glu Leu Asp Pro Glu Ala Asn Gln Asp Ala Pro Asp Ala Gly Ala Leu 
        195                 200                 205             


Gln Arg Gly Gly Gly Asp Pro Pro Ala Ile Leu Pro His Cys Gly Glu 
    210                 215                 220                 


<210>  603
<211>  4698
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (252)..(1184)

<400>  603
gttggtgaag agatcaggaa gagatttctt cgagactaag gatggatgac ccttagcaac       60

agtgaccgtc tcctcccggc atagcaagat ggcctgccct caggtacagg aagaaggaat      120

ggaatcggaa ggaagaaaat tcattccaga gacaaaatag ctcccctcct ctgttgtagc      180

tgttcctctg gcaatacaaa ctttctgctt tcaggttctg cagcattcca gaccttgagc      240

actgaatcag g atg gga aaa aga cgt tgt gtt cct cca ctc gag ccc aag       290
             Met Gly Lys Arg Arg Cys Val Pro Pro Leu Glu Pro Lys          
             1               5                   10                       

ttg gca gca ggc tgt tgt ggg gtc aag aag ccc aaa tta tct gga agt        338
Leu Ala Ala Gly Cys Cys Gly Val Lys Lys Pro Lys Leu Ser Gly Ser           
    15                  20                  25                            

gga acg cac agt cac ggg aat cag tcc aca act gtc ccc ggc tct agt        386
Gly Thr His Ser His Gly Asn Gln Ser Thr Thr Val Pro Gly Ser Ser           
30                  35                  40                  45            

tca gga cct ctt caa aac cac cag cat gtg gac agc agc agt gga cgg        434
Ser Gly Pro Leu Gln Asn His Gln His Val Asp Ser Ser Ser Gly Arg           
                50                  55                  60                

gag aat gtg tca gac tta act ctg gga cct gga aac tct ccc atc aca        482
Glu Asn Val Ser Asp Leu Thr Leu Gly Pro Gly Asn Ser Pro Ile Thr           
            65                  70                  75                    

cga atg aat ccc gca tcg gga gcg ctg agc cct ctt ccc cgg cct aat        530
Arg Met Asn Pro Ala Ser Gly Ala Leu Ser Pro Leu Pro Arg Pro Asn           
        80                  85                  90                        

gga act gcc aac acc act aag aat ctg gtg gtg act gca gag atg tgc        578
Gly Thr Ala Asn Thr Thr Lys Asn Leu Val Val Thr Ala Glu Met Cys           
    95                  100                 105                           

tgc tac tgc ttc gac gta ctc tac tgt cac ctc tat ggc ttc cca cag        626
Cys Tyr Cys Phe Asp Val Leu Tyr Cys His Leu Tyr Gly Phe Pro Gln           
110                 115                 120                 125           

cca cga ctt cct aga ttc acc aat gac ccc tat ccg ctc ttt gtg acg        674
Pro Arg Leu Pro Arg Phe Thr Asn Asp Pro Tyr Pro Leu Phe Val Thr           
                130                 135                 140               

tgg aag aca ggg cgg gac aag cgg ctt cgt ggc tgc att ggg acc ttc        722
Trp Lys Thr Gly Arg Asp Lys Arg Leu Arg Gly Cys Ile Gly Thr Phe           
            145                 150                 155                   

tca gcc atg aat ctt cat tca gga ctc agg gaa tac acg tta acc agt        770
Ser Ala Met Asn Leu His Ser Gly Leu Arg Glu Tyr Thr Leu Thr Ser           
        160                 165                 170                       

gca ctt aag gac agc cga ttt ccc ccc ctg acc cga gag gag ctg cct        818
Ala Leu Lys Asp Ser Arg Phe Pro Pro Leu Thr Arg Glu Glu Leu Pro           
    175                 180                 185                           

aaa ctt ttc tgc tct gtc tcc ctc ctt act aac ttt gag gat gcc agt        866
Lys Leu Phe Cys Ser Val Ser Leu Leu Thr Asn Phe Glu Asp Ala Ser           
190                 195                 200                 205           

gat tac ctg gac tgg gag gta ggg gtc cat ggg att cga att gaa ttc        914
Asp Tyr Leu Asp Trp Glu Val Gly Val His Gly Ile Arg Ile Glu Phe           
                210                 215                 220               

att aat gaa aaa ggt gtc aaa cgc aca gcc aca tat tta cct gag gtt        962
Ile Asn Glu Lys Gly Val Lys Arg Thr Ala Thr Tyr Leu Pro Glu Val           
            225                 230                 235                   

gct aag gaa caa gac tgg gat cag atc cag aca ata gac tcc ttg ctc       1010
Ala Lys Glu Gln Asp Trp Asp Gln Ile Gln Thr Ile Asp Ser Leu Leu           
        240                 245                 250                       

agg aaa ggt ggc ttt aaa gct cca att acc agt gaa ttc aga aaa acg       1058
Arg Lys Gly Gly Phe Lys Ala Pro Ile Thr Ser Glu Phe Arg Lys Thr           
    255                 260                 265                           

atc aaa ctc acc agg tac cga agt gag aag gtg aca atc agt tac gca       1106
Ile Lys Leu Thr Arg Tyr Arg Ser Glu Lys Val Thr Ile Ser Tyr Ala           
270                 275                 280                 285           

gag tat att gct tcc cga cag cac tgt ttc cag aac ggc act ctt cat       1154
Glu Tyr Ile Ala Ser Arg Gln His Cys Phe Gln Asn Gly Thr Leu His           
                290                 295                 300               

gcc ccg ccc ctc tac aat cat tac tcc tga cacacggctg catgaccagt         1204
Ala Pro Pro Leu Tyr Asn His Tyr Ser                                       
            305                 310                                       

cccacccccc cgtggccacc aatggctatg acatcattgg agcagatgcc tcctcttcct     1264

ggtccagtta cttctattac tgcaccattt tatgatgcta gcttccgttg ccaagtctgc     1324

ctcccgctga ctgagggagg gtagggttac cttgaacgaa acagaacttg aggggcccaa     1384

gccttatctc agcctttcct caatatgggg ttccgttgga ttggggctcc tccatgacta     1444

gtgggaatta ctgtgggttc agaagaccct tgtctggtat ttgccacatg gggtattggc     1504

cacacgctgg aagctgaaat tgatgatccc tgaaggttga acccacacac acccctgcag     1564

cctccccaga tgaagtaggt gtattcccct ggcagtctgg gcaacggaga ccaagaaaca     1624

tttttaggtt gttttaaatt ccttttttta aacttccagt ttattgcgta ccaagagttg     1684

attacaacct ccatgcttca taagcggacg ccacgttagg gttggacgtg ggcaccacga     1744

gtcctttgag gctcctggac agagacccac atcaagatcg gaagcccttt gggtggcgtt     1804

gcagatctca ttgctcagta ggccgtgaag attttcatcc tcatcccact ctcagttgga     1864

ttttctggca ctcttcctgc attgagtctc ctgattactg aacagagctc cgtcatgtag     1924

cctgctgagg aatggaatgg aatggagatg cccacaggag gtcctgatgt catcactgca     1984

cgcaggtgtg agaggagaga cctcttctgc accgcctggc tacctcactc ctctgctggt     2044

agcagtgcct atagctggac ctaagttctc agaagcgtag atgtgcaaac aagcgattga     2104

gttgggcttt aggaggacac atcataggag agaatccagg gtctgtaagc tggttttctt     2164

ttcaggtgac atcctgaggg gcctgtaagc aggggagctc ctttttctag tttgcctgta     2224

gaggtgggaa gactgttggt gtttctgtcc tttacaggac attaggaaac agttgtgtaa     2284

ttacacaagg tggaccttta tcttgcctga catgctggga atcttcaccc caccagggca     2344

aatttccaaa tagctcattt tattctaggt ctttcaaact ttcatgtgac atatttccct     2404

ttcccattgt tgctgatttc caaatcgctg tcagcaattt tttcctctct ccttgcctat     2464

tcttcactca tttggtggca aagttcatag aactagggga cttggaagat gctttgaaaa     2524

tattgttaca aaggcactgc taaaatgatt cacagggaga gtggccagtt ggaagaagga     2584

tcctaaggat gtgacactgg ttttcaacaa catgcttaga gaactcatga agtggattgg     2644

gtgtcaaccc agtgaacatg tttttattta atttattttt tgaagtttat gtggtgatgg     2704

tgtggctttc cgaaatgggc aaatattcag aagatctttt gcattttctt ctgtcaggaa     2764

tggggaaggg gagtgggggc acaatctgag aaaggacacc tgtgctgttc taggcatcgc     2824

tggcaagttt gtgggaaggg atgggcaagg gtgagtgggt ttgctccaca ccgtcctgtg     2884

ctgctcgaga ggacctggga cgtgcgaggg aaacgtgggt gacggtgcct aggctgcggc     2944

ccttcactgc tgtgctgggt tcctgcagcc tgctacgttt cccttggcaa tgtaaatgaa     3004

gatggagggg tcgtttcgtg atttcctgct gctgagaata aatgtcttgt taaaaacgtg     3064

gcaacggtta ctcttaggtg ccatggatcg atgtcagggt ggtcagctct ggactaagcc     3124

acccacctcc aatttgtaca acagtattga tacatagggc tacactcatt actgttcaag     3184

tgttctatgt taagagttgt gtttaatttc taaagattaa aaaaagcaaa aaaattggtg     3244

ctaaaccttc acccctgagc acgctcagtg agactggtca tgcaagcatt tacagtgcca     3304

tgctcctcaa gccgattttt tcttgtagaa atgttgccct atttgtcttc tccaatgtat     3364

ggtatgttat tttattttat tattttattt tattttattt tattttatcg agggggggta     3424

cgatacctgc catttaagaa aatgaataga aaattttaaa acccgagaaa tggggaaaaa     3484

aaaatcagtg cacaagaatt gggctggtta ggcccagcac cacactgaag tgggctcagt     3544

ggtttttgga gtgaagaagc cttactccct gcacattccc tcatgctccc acacaagtcc     3604

agcaatggaa atgcttgggt tcctcttgct ttgtcagggg actcaggagt cgaccaaggg     3664

aaaccatttg gccccgtgag gaatgggcat tgtcagtatc cgtcctgaac ggggcctagt     3724

caggaagcgg tctagaagtg tacggtcacg gtcgcctcat gaaagtgtgt agcaggtggc     3784

tctcaggaaa aataccaagt ctggatcatc catgtggcag ctttgcatag ggagaggata     3844

gctccgaact ggaactgaac tgccttctct gcacgcttga ccaaagcagt gatgagggcg     3904

gccagtacct gcggtgtgcg tggtaggttt aaagaaaagg gaatgttttc tgctgagtgt     3964

ttcctttgtc cttgggctgc tcgagctgga cagtaggtaa ccactgtttt caaggaccag     4024

cccaatttct ctggcttggt tcggagttcg tttcatccct agctgtgagt gccttttggt     4084

ctggaaagtt ggcttgtctc ataataccca cagctaggac attctctctg taattatgaa     4144

ttgtccttgt tttacattaa aagagaatgt ctttgatcac tagagtctgt cggtgttgga     4204

ttatttccac tgtgagattc ttaaaacttt tttgcttcat aataataaaa caactcatgt     4264

tagagaccct ttcaacatga aaggtttgta gttgagacat tacatatatt ttattgttta     4324

taataaaaat catctataca aaagaagtcc tgggtgttaa tattttgcac aagatctgtt     4384

ttccatgatg tgttgacatc tacaatttca ctaactgttg acgttatttt ctattgagat     4444

tctggagcct agggagctat gtgttctttt tgttcatttc gttcttactt ccctgaagca     4504

agagactata tggccttcag tgcaaagact tcagaccaat tctttgtatt acacttggtt     4564

gcctcttggc tatataactt ctgagtgcaa atcattgaac actttaacga agtattgtag     4624

agaataaatc ataatggata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4684

aaaaaaaaaa aaaa                                                       4698


<210>  604
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  604

Met Gly Lys Arg Arg Cys Val Pro Pro Leu Glu Pro Lys Leu Ala Ala 
1               5                   10                  15      


Gly Cys Cys Gly Val Lys Lys Pro Lys Leu Ser Gly Ser Gly Thr His 
            20                  25                  30          


Ser His Gly Asn Gln Ser Thr Thr Val Pro Gly Ser Ser Ser Gly Pro 
        35                  40                  45              


Leu Gln Asn His Gln His Val Asp Ser Ser Ser Gly Arg Glu Asn Val 
    50                  55                  60                  


Ser Asp Leu Thr Leu Gly Pro Gly Asn Ser Pro Ile Thr Arg Met Asn 
65                  70                  75                  80  


Pro Ala Ser Gly Ala Leu Ser Pro Leu Pro Arg Pro Asn Gly Thr Ala 
                85                  90                  95      


Asn Thr Thr Lys Asn Leu Val Val Thr Ala Glu Met Cys Cys Tyr Cys 
            100                 105                 110         


Phe Asp Val Leu Tyr Cys His Leu Tyr Gly Phe Pro Gln Pro Arg Leu 
        115                 120                 125             


Pro Arg Phe Thr Asn Asp Pro Tyr Pro Leu Phe Val Thr Trp Lys Thr 
    130                 135                 140                 


Gly Arg Asp Lys Arg Leu Arg Gly Cys Ile Gly Thr Phe Ser Ala Met 
145                 150                 155                 160 


Asn Leu His Ser Gly Leu Arg Glu Tyr Thr Leu Thr Ser Ala Leu Lys 
                165                 170                 175     


Asp Ser Arg Phe Pro Pro Leu Thr Arg Glu Glu Leu Pro Lys Leu Phe 
            180                 185                 190         


Cys Ser Val Ser Leu Leu Thr Asn Phe Glu Asp Ala Ser Asp Tyr Leu 
        195                 200                 205             


Asp Trp Glu Val Gly Val His Gly Ile Arg Ile Glu Phe Ile Asn Glu 
    210                 215                 220                 


Lys Gly Val Lys Arg Thr Ala Thr Tyr Leu Pro Glu Val Ala Lys Glu 
225                 230                 235                 240 


Gln Asp Trp Asp Gln Ile Gln Thr Ile Asp Ser Leu Leu Arg Lys Gly 
                245                 250                 255     


Gly Phe Lys Ala Pro Ile Thr Ser Glu Phe Arg Lys Thr Ile Lys Leu 
            260                 265                 270         


Thr Arg Tyr Arg Ser Glu Lys Val Thr Ile Ser Tyr Ala Glu Tyr Ile 
        275                 280                 285             


Ala Ser Arg Gln His Cys Phe Gln Asn Gly Thr Leu His Ala Pro Pro 
    290                 295                 300                 


Leu Tyr Asn His Tyr Ser 
305                 310 


<210>  605
<211>  4072
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (267)..(1829)

<400>  605
tttccgggcc gagtgtttcc gggtcgctgc tggcccccgg gtactggtct cagtacccct       60

gcagccggcc ggagaggcta gagcccgacg gggcccggct ccggcggcag ccgcgcctct      120

cgcttgcttc cctcggccgg gccgtcctcg gcggcagtgt caggagcact ccgctggtcc      180

aggcggcaac atgtccatgc ttttagtgat gtccctgcct ctaatccaga agccatggag      240

gagataaggt agcccccctc gatcgg atg ggg aag ccc agt tca atg gat act       293
                             Met Gly Lys Pro Ser Ser Met Asp Thr          
                             1               5                            

aaa ttc aag gat gac tta ttt cgg aag tac gtg cag ttc cat gag agc        341
Lys Phe Lys Asp Asp Leu Phe Arg Lys Tyr Val Gln Phe His Glu Ser           
10                  15                  20                  25            

aaa gtg gat acc acc acc agc agg cag cgg cct ggc agc gat gag tgc        389
Lys Val Asp Thr Thr Thr Ser Arg Gln Arg Pro Gly Ser Asp Glu Cys           
                30                  35                  40                

ctg cgg gtg gca gcc tca acc ctg ctc agc ctg cac aag gtg gat ccc        437
Leu Arg Val Ala Ala Ser Thr Leu Leu Ser Leu His Lys Val Asp Pro           
            45                  50                  55                    

ttt tat cga ttc cgg ctg atc cag ttc tat gag gtg gtg gag agc tcc        485
Phe Tyr Arg Phe Arg Leu Ile Gln Phe Tyr Glu Val Val Glu Ser Ser           
        60                  65                  70                        

ttg cgc tcg ctc agc tcc tct agc ctg cgg gct ctg cac ggc gcc ttc        533
Leu Arg Ser Leu Ser Ser Ser Ser Leu Arg Ala Leu His Gly Ala Phe           
    75                  80                  85                            

agc atg ctg gag acg gtg ggc atc aac ctc ttc ctc tac ccg tgg aag        581
Ser Met Leu Glu Thr Val Gly Ile Asn Leu Phe Leu Tyr Pro Trp Lys           
90                  95                  100                 105           

aag gaa ttc aga agc atc aag acc tac acg ggc cct ttt gtt tat tat        629
Lys Glu Phe Arg Ser Ile Lys Thr Tyr Thr Gly Pro Phe Val Tyr Tyr           
                110                 115                 120               

gtc aag tcg aca tta ctg gaa gag gac atc cga gcc atc ctg agc tgc        677
Val Lys Ser Thr Leu Leu Glu Glu Asp Ile Arg Ala Ile Leu Ser Cys           
            125                 130                 135                   

atg ggc tac aca cct gag ctg ggc act gca tac aag ctc aga gag ctc        725
Met Gly Tyr Thr Pro Glu Leu Gly Thr Ala Tyr Lys Leu Arg Glu Leu           
        140                 145                 150                       

gtg gag acc ctc cag gtg aag atg gtc tcc ttt gag ctc ttt ctg gcc        773
Val Glu Thr Leu Gln Val Lys Met Val Ser Phe Glu Leu Phe Leu Ala           
    155                 160                 165                           

aaa gtc gag tgt gag cag atg cta gaa atc cac tca caa gtg aag gac        821
Lys Val Glu Cys Glu Gln Met Leu Glu Ile His Ser Gln Val Lys Asp           
170                 175                 180                 185           

aag ggc tac tcc gag ctg gac att gtg agc gag cgc aag agc agt gca        869
Lys Gly Tyr Ser Glu Leu Asp Ile Val Ser Glu Arg Lys Ser Ser Ala           
                190                 195                 200               

gag gat gtg cgc ggc tgc tcg gac gcc ctg cgg cgg cgg gca gag ggc        917
Glu Asp Val Arg Gly Cys Ser Asp Ala Leu Arg Arg Arg Ala Glu Gly           
            205                 210                 215                   

cgg gag cac ctg acg gcc tcc atg tca cga gtg gca ctc cag aag tcg        965
Arg Glu His Leu Thr Ala Ser Met Ser Arg Val Ala Leu Gln Lys Ser           
        220                 225                 230                       

gcc agc gag cgg gcg gcc aag gac tac tac aag ccc cgc gtg acc aag       1013
Ala Ser Glu Arg Ala Ala Lys Asp Tyr Tyr Lys Pro Arg Val Thr Lys           
    235                 240                 245                           

ccc tcg agg tca gtg gat gcc tat gac agc tac tgg gag agc cgg aag       1061
Pro Ser Arg Ser Val Asp Ala Tyr Asp Ser Tyr Trp Glu Ser Arg Lys           
250                 255                 260                 265           

cca ccc ctg aag gcc tca ttg agt ctt cgg aag gag cct gtg gca acg       1109
Pro Pro Leu Lys Ala Ser Leu Ser Leu Arg Lys Glu Pro Val Ala Thr           
                270                 275                 280               

gat gtg ggg gac gac ctc aag gat gag atc atc cgc cca tcc cct tcg       1157
Asp Val Gly Asp Asp Leu Lys Asp Glu Ile Ile Arg Pro Ser Pro Ser           
            285                 290                 295                   

ctg ctg acc atg gcc agc tcc ccc cac ggc agc ccg gat gtg ctt cca       1205
Leu Leu Thr Met Ala Ser Ser Pro His Gly Ser Pro Asp Val Leu Pro           
        300                 305                 310                       

ccc gcc tcc ccc agc aac ggc ccg gcc ctg ctg cgc ggt acc tac ttc       1253
Pro Ala Ser Pro Ser Asn Gly Pro Ala Leu Leu Arg Gly Thr Tyr Phe           
    315                 320                 325                           

tcc act cag gat gac gtg gat ctg tac aca gac tct gaa ccc agg gcc       1301
Ser Thr Gln Asp Asp Val Asp Leu Tyr Thr Asp Ser Glu Pro Arg Ala           
330                 335                 340                 345           

acc tac cgt cgg cag gat gct ctg cgg ccg gat gtg tgg ctg ctc aga       1349
Thr Tyr Arg Arg Gln Asp Ala Leu Arg Pro Asp Val Trp Leu Leu Arg           
                350                 355                 360               

aac gat gcc cac tcc ctc tac cac aag cgc tcg ccc cct gcc aaa gag       1397
Asn Asp Ala His Ser Leu Tyr His Lys Arg Ser Pro Pro Ala Lys Glu           
            365                 370                 375                   

tcc gcc ctc tcc aag tgc caa agc tgc ggg ctg tcc tgc agc tcc tcc       1445
Ser Ala Leu Ser Lys Cys Gln Ser Cys Gly Leu Ser Cys Ser Ser Ser           
        380                 385                 390                       

ctc tgc cag cgc tgt gac agc ctg ctc acc tgt cct cca gct tcc aag       1493
Leu Cys Gln Arg Cys Asp Ser Leu Leu Thr Cys Pro Pro Ala Ser Lys           
    395                 400                 405                           

ccc agc gcc ttc ccc agc aag gcc tcg act cat gac agc ctg gcc cac       1541
Pro Ser Ala Phe Pro Ser Lys Ala Ser Thr His Asp Ser Leu Ala His           
410                 415                 420                 425           

ggg gca tct ctg cgg gag aag tac cca ggc cag act cag ggc ctc gac       1589
Gly Ala Ser Leu Arg Glu Lys Tyr Pro Gly Gln Thr Gln Gly Leu Asp           
                430                 435                 440               

cgc ctc ccg cac ctt cac tcc aaa tcc aag ccc tcc acc acg ccc act       1637
Arg Leu Pro His Leu His Ser Lys Ser Lys Pro Ser Thr Thr Pro Thr           
            445                 450                 455                   

tcc cgc tgt ggc ttc tgc aac cgc cca ggc gcc acc aac acc tgc acc       1685
Ser Arg Cys Gly Phe Cys Asn Arg Pro Gly Ala Thr Asn Thr Cys Thr           
        460                 465                 470                       

cag tgt tca aaa gtc tca tgt gac gcc tgc ctc agc gct tac cat tat       1733
Gln Cys Ser Lys Val Ser Cys Asp Ala Cys Leu Ser Ala Tyr His Tyr           
    475                 480                 485                           

gac ccc tgc tac aaa aag agt gag ctg cac aag ttc atg ccc aac aac       1781
Asp Pro Cys Tyr Lys Lys Ser Glu Leu His Lys Phe Met Pro Asn Asn           
490                 495                 500                 505           

cag ctg aac tac aag tcc acc cag ctc tcc cat ctc gtg tac aga tag       1829
Gln Leu Asn Tyr Lys Ser Thr Gln Leu Ser His Leu Val Tyr Arg               
                510                 515                 520               

accggcctcg ccccttccag ctccaagggc tacatcaacc gacctttcgg gtttcacggt     1889

gaagaagtac taacgcattg atctcagagg cggaggcctg cacttgacca tgtaggtggc     1949

agagatcgtg ggctggctgt gtccacgtgg gagttcactt agcgactcag atatctcaac     2009

caatggctgc tttgttgtct gacaagggag aaggtggcac ttccgttcag attcattttg     2069

ctaatctctc cactccctgt tcagttggtt ctttttttgg ggttttgttt tgttttgttt     2129

tgttgttttg ttttttcctt taaagaggat ttctgtctct gggaccctcg ctgcacctac     2189

ccctcccatt gcaaagccaa cttggactgg gaagggccct tcaggtcacc aaacatccac     2249

ctggagcggc gagctagagg cctgttggct tgtgaaatga gccctcctgc cacacggggc     2309

ctctcccaaa ggctcatccc ttggccgccc ccttcctaaa cacaaggatc cccagctgga     2369

ctccccaccc cctggcttcc ccacctctcc aggtgtcaaa ggtgaaccga gtccagtatt     2429

agctgaatgt catttcgtac accacagctc agtcagccca tggccttcgt gaactttgct     2489

ccaacacact gatgtgtggg cttcccacag caggactgac ttcccccttt ctgttgtttg     2549

cacatgcccc tcttactgta ctgtcaatag atatttttga gatttatttt taaataaata     2609

ttcaacttgc tgtgtgtttc aacgtggtta aaaaaatgaa ttatgtagct atttattaaa     2669

tgccctgggt tctttagtct tccaagggag ggcctcgcgc ccattcgtgt tgtatcctcc     2729

actcactatg gcccgagggg agaggagagt ttggggcagg gaggaacaga catgaagcct     2789

ccttttcttg agctggtgga gagccactgt cttccctgca gtaactatct atacacctac     2849

ctccagtgtg cacttagggg gtgagcgcgg gtgtcgaggt ctgtgtgtct gcagactgct     2909

aacctatgac aattcaggga cctcacctgt cggacctata gcttgctgag caggaacctt     2969

gcacttcaca cttcttgagt ctcgtttcag aaggaaaatc atttgggatt cctactgccc     3029

ctccatctca atcctcttct cttcaccagt ttccaggact catctgcaac atttgcaatc     3089

tttttgcact aaaagtgggc aggagtcggc atgtgcccat cagagagacg gctcctcaga     3149

tgctcagcta agcctaagcg cttccaagcc tgaaggcccc ttcagcttct catgtgaatt     3209

accaacccct ggattttcct tgtgggggta caagagcagg agtggggcaa gagtttgaaa     3269

ataaagccgc ttccttgtga actaactata ttttagccat aactgtttgt gatgtacaca     3329

atgttaaggg atttatatgc agtgggcttt tctgggagaa agttattcag ctcttgagca     3389

agtttaagtc tggctgaatc ctgaggccac tgtgaatttg ctgatgttct tccaactcag     3449

ttgagtgatt ttaaggtttt ccaaatcttc tatggctctc tttttaatat atatatatat     3509

atatatatat atatatatat atatatatat atatatctat ctggtagatc acatgtagat     3569

gtacagtgtg tatattaagc tgaatttcaa ccaactttat tactaagacc agcctagcag     3629

ggcattcatc tttgatgttc ttccttttca catttcagaa tcggcaatgc ctggcccact     3689

cctgagagct ctagttttct agttttccat ttccagattg cgccagcatt acagtaacta     3749

actctttcta accaaccgtg atgccacgta acttacccta tggacaaaag caggaatgac     3809

taacacatcc taggagggaa agtccagtgt acctgtcatc acggacgcac tgtggtcaca     3869

gactggaata cgaaatacta cagccctgct cccaggtgtg catcttactg gatgaggttg     3929

ctgtgattga gatagttaaa tacatgctaa tttaaaaatg cagatgtttt acatttgatt     3989

tctaccaaga gttgaaatgt tgagagatga ttaaaaataa taataataaa gtgtcttcca     4049

ttgttaaaaa aaaaaaaaaa aaa                                             4072


<210>  606
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  606

Met Gly Lys Pro Ser Ser Met Asp Thr Lys Phe Lys Asp Asp Leu Phe 
1               5                   10                  15      


Arg Lys Tyr Val Gln Phe His Glu Ser Lys Val Asp Thr Thr Thr Ser 
            20                  25                  30          


Arg Gln Arg Pro Gly Ser Asp Glu Cys Leu Arg Val Ala Ala Ser Thr 
        35                  40                  45              


Leu Leu Ser Leu His Lys Val Asp Pro Phe Tyr Arg Phe Arg Leu Ile 
    50                  55                  60                  


Gln Phe Tyr Glu Val Val Glu Ser Ser Leu Arg Ser Leu Ser Ser Ser 
65                  70                  75                  80  


Ser Leu Arg Ala Leu His Gly Ala Phe Ser Met Leu Glu Thr Val Gly 
                85                  90                  95      


Ile Asn Leu Phe Leu Tyr Pro Trp Lys Lys Glu Phe Arg Ser Ile Lys 
            100                 105                 110         


Thr Tyr Thr Gly Pro Phe Val Tyr Tyr Val Lys Ser Thr Leu Leu Glu 
        115                 120                 125             


Glu Asp Ile Arg Ala Ile Leu Ser Cys Met Gly Tyr Thr Pro Glu Leu 
    130                 135                 140                 


Gly Thr Ala Tyr Lys Leu Arg Glu Leu Val Glu Thr Leu Gln Val Lys 
145                 150                 155                 160 


Met Val Ser Phe Glu Leu Phe Leu Ala Lys Val Glu Cys Glu Gln Met 
                165                 170                 175     


Leu Glu Ile His Ser Gln Val Lys Asp Lys Gly Tyr Ser Glu Leu Asp 
            180                 185                 190         


Ile Val Ser Glu Arg Lys Ser Ser Ala Glu Asp Val Arg Gly Cys Ser 
        195                 200                 205             


Asp Ala Leu Arg Arg Arg Ala Glu Gly Arg Glu His Leu Thr Ala Ser 
    210                 215                 220                 


Met Ser Arg Val Ala Leu Gln Lys Ser Ala Ser Glu Arg Ala Ala Lys 
225                 230                 235                 240 


Asp Tyr Tyr Lys Pro Arg Val Thr Lys Pro Ser Arg Ser Val Asp Ala 
                245                 250                 255     


Tyr Asp Ser Tyr Trp Glu Ser Arg Lys Pro Pro Leu Lys Ala Ser Leu 
            260                 265                 270         


Ser Leu Arg Lys Glu Pro Val Ala Thr Asp Val Gly Asp Asp Leu Lys 
        275                 280                 285             


Asp Glu Ile Ile Arg Pro Ser Pro Ser Leu Leu Thr Met Ala Ser Ser 
    290                 295                 300                 


Pro His Gly Ser Pro Asp Val Leu Pro Pro Ala Ser Pro Ser Asn Gly 
305                 310                 315                 320 


Pro Ala Leu Leu Arg Gly Thr Tyr Phe Ser Thr Gln Asp Asp Val Asp 
                325                 330                 335     


Leu Tyr Thr Asp Ser Glu Pro Arg Ala Thr Tyr Arg Arg Gln Asp Ala 
            340                 345                 350         


Leu Arg Pro Asp Val Trp Leu Leu Arg Asn Asp Ala His Ser Leu Tyr 
        355                 360                 365             


His Lys Arg Ser Pro Pro Ala Lys Glu Ser Ala Leu Ser Lys Cys Gln 
    370                 375                 380                 


Ser Cys Gly Leu Ser Cys Ser Ser Ser Leu Cys Gln Arg Cys Asp Ser 
385                 390                 395                 400 


Leu Leu Thr Cys Pro Pro Ala Ser Lys Pro Ser Ala Phe Pro Ser Lys 
                405                 410                 415     


Ala Ser Thr His Asp Ser Leu Ala His Gly Ala Ser Leu Arg Glu Lys 
            420                 425                 430         


Tyr Pro Gly Gln Thr Gln Gly Leu Asp Arg Leu Pro His Leu His Ser 
        435                 440                 445             


Lys Ser Lys Pro Ser Thr Thr Pro Thr Ser Arg Cys Gly Phe Cys Asn 
    450                 455                 460                 


Arg Pro Gly Ala Thr Asn Thr Cys Thr Gln Cys Ser Lys Val Ser Cys 
465                 470                 475                 480 


Asp Ala Cys Leu Ser Ala Tyr His Tyr Asp Pro Cys Tyr Lys Lys Ser 
                485                 490                 495     


Glu Leu His Lys Phe Met Pro Asn Asn Gln Leu Asn Tyr Lys Ser Thr 
            500                 505                 510         


Gln Leu Ser His Leu Val Tyr Arg 
        515                 520 


<210>  607
<211>  3754
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (214)..(2430)

<400>  607
ccaggcccca ttgttcccgg tttccagcca tggctgccat tacctgacca gcgccacagc       60

cggtctctct gcaggcgccg ggagaagtga ccagagcaat ttctgctttt cacagggcgg      120

gtttctcaac ggtgacttgt gggcagtgcc ttctgctgag cgagtcatgg cccgaaggca      180

gaactaactg tgcctgcagt cttcactctc agg atg cag ccg agg tgg gcc caa       234
                                     Met Gln Pro Arg Trp Ala Gln          
                                     1               5                    

ggg gcc acg atg tgg ctt gga gtc ctg ctg acc ctt ctg ctc tgt tca        282
Gly Ala Thr Met Trp Leu Gly Val Leu Leu Thr Leu Leu Leu Cys Ser           
        10                  15                  20                        

agc ctt gag ggt caa gaa aac tct ttc aca atc aac agt gtt gac atg        330
Ser Leu Glu Gly Gln Glu Asn Ser Phe Thr Ile Asn Ser Val Asp Met           
    25                  30                  35                            

aag agc ctg ccg gac tgg acg gtg caa aat ggg aag aac ctg acc ctg        378
Lys Ser Leu Pro Asp Trp Thr Val Gln Asn Gly Lys Asn Leu Thr Leu           
40                  45                  50                  55            

cag tgc ttc gcg gat gtc agc acc acc tct cac gtc aag cct cag cac        426
Gln Cys Phe Ala Asp Val Ser Thr Thr Ser His Val Lys Pro Gln His           
                60                  65                  70                

cag atg ctg ttc tat aag gat gac gtg ctg ttt tac aac atc tcc tcc        474
Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser           
            75                  80                  85                    

atg aag agc aca gag agt tat ttt att cct gaa gtc cgg atc tat gac        522
Met Lys Ser Thr Glu Ser Tyr Phe Ile Pro Glu Val Arg Ile Tyr Asp           
        90                  95                  100                       

tca ggg aca tat aaa tgt act gtg att gtg aac aac aaa gag aaa acc        570
Ser Gly Thr Tyr Lys Cys Thr Val Ile Val Asn Asn Lys Glu Lys Thr           
    105                 110                 115                           

act gca gag tac cag ctg ttg gtg gaa gga gtg ccc agt ccc agg gtg        618
Thr Ala Glu Tyr Gln Leu Leu Val Glu Gly Val Pro Ser Pro Arg Val           
120                 125                 130                 135           

aca ctg gac aag aaa gag gcc atc caa ggt ggg atc gtg agg gtc aac        666
Thr Leu Asp Lys Lys Glu Ala Ile Gln Gly Gly Ile Val Arg Val Asn           
                140                 145                 150               

tgt tct gtc cca gag gaa aag gcc cca ata cac ttc aca att gaa aaa        714
Cys Ser Val Pro Glu Glu Lys Ala Pro Ile His Phe Thr Ile Glu Lys           
            155                 160                 165                   

ctt gaa cta aat gaa aaa atg gtc aag ctg aaa aga gag aag aat tct        762
Leu Glu Leu Asn Glu Lys Met Val Lys Leu Lys Arg Glu Lys Asn Ser           
        170                 175                 180                       

cga gac cag aat ttt gtg ata ctg gaa ttc ccc gtt gag gaa cag gac        810
Arg Asp Gln Asn Phe Val Ile Leu Glu Phe Pro Val Glu Glu Gln Asp           
    185                 190                 195                           

cgc gtt tta tcc ttc cga tgt caa gct agg atc att tct ggg atc cat        858
Arg Val Leu Ser Phe Arg Cys Gln Ala Arg Ile Ile Ser Gly Ile His           
200                 205                 210                 215           

atg cag acc tca gaa tct acc aag agt gaa ctg gtc acc gtg acg gaa        906
Met Gln Thr Ser Glu Ser Thr Lys Ser Glu Leu Val Thr Val Thr Glu           
                220                 225                 230               

tcc ttc tct aca ccc aag ttc cac atc agc ccc acc gga atg atc atg        954
Ser Phe Ser Thr Pro Lys Phe His Ile Ser Pro Thr Gly Met Ile Met           
            235                 240                 245                   

gaa gga gct cag ctc cac att aag tgc acc att caa gtg act cac ctg       1002
Glu Gly Ala Gln Leu His Ile Lys Cys Thr Ile Gln Val Thr His Leu           
        250                 255                 260                       

gcc cag gag ttt cca gaa atc ata att cag aag gac aag gcg att gtg       1050
Ala Gln Glu Phe Pro Glu Ile Ile Ile Gln Lys Asp Lys Ala Ile Val           
    265                 270                 275                           

gcc cac aac aga cat ggc aac aag gct gtg tac tca gtc atg gcc atg       1098
Ala His Asn Arg His Gly Asn Lys Ala Val Tyr Ser Val Met Ala Met           
280                 285                 290                 295           

gtg gag cac agt ggc aac tac acg tgc aaa gtg gag tcc agc cgc ata       1146
Val Glu His Ser Gly Asn Tyr Thr Cys Lys Val Glu Ser Ser Arg Ile           
                300                 305                 310               

tcc aag gtc agc agc atc gtg gtc aac ata aca gaa cta ttt tcc aag       1194
Ser Lys Val Ser Ser Ile Val Val Asn Ile Thr Glu Leu Phe Ser Lys           
            315                 320                 325                   

ccc gaa ctg gaa tct tcc ttc aca cat ctg gac caa ggt gaa aga ctg       1242
Pro Glu Leu Glu Ser Ser Phe Thr His Leu Asp Gln Gly Glu Arg Leu           
        330                 335                 340                       

aac ctg tcc tgc tcc atc cca gga gca cct cca gcc aac ttc acc atc       1290
Asn Leu Ser Cys Ser Ile Pro Gly Ala Pro Pro Ala Asn Phe Thr Ile           
    345                 350                 355                           

cag aag gaa gat acg att gtg tca cag act caa gat ttc acc aag ata       1338
Gln Lys Glu Asp Thr Ile Val Ser Gln Thr Gln Asp Phe Thr Lys Ile           
360                 365                 370                 375           

gcc tca aag tcg gac agt ggg acg tat atc tgc act gca ggt att gac       1386
Ala Ser Lys Ser Asp Ser Gly Thr Tyr Ile Cys Thr Ala Gly Ile Asp           
                380                 385                 390               

aaa gtg gtc aag aaa agc aac aca gtc cag ata gtc gta tgt gaa atg       1434
Lys Val Val Lys Lys Ser Asn Thr Val Gln Ile Val Val Cys Glu Met           
            395                 400                 405                   

ctc tcc cag ccc agg att tct tat gat gcc cag ttt gag gtc ata aaa       1482
Leu Ser Gln Pro Arg Ile Ser Tyr Asp Ala Gln Phe Glu Val Ile Lys           
        410                 415                 420                       

gga cag acc atc gaa gtc cgt tgc gaa tcg atc agt gga act ttg cct       1530
Gly Gln Thr Ile Glu Val Arg Cys Glu Ser Ile Ser Gly Thr Leu Pro           
    425                 430                 435                           

att tct tac caa ctt tta aaa aca agt aaa gtt ttg gag aat agt acc       1578
Ile Ser Tyr Gln Leu Leu Lys Thr Ser Lys Val Leu Glu Asn Ser Thr           
440                 445                 450                 455           

aag aac tca aat gat cct gcg gta ttc aaa gac aac ccc act gaa gac       1626
Lys Asn Ser Asn Asp Pro Ala Val Phe Lys Asp Asn Pro Thr Glu Asp           
                460                 465                 470               

gtc gaa tac cag tgt gtt gca gat aat tgc cat tcc cac gcc aaa atg       1674
Val Glu Tyr Gln Cys Val Ala Asp Asn Cys His Ser His Ala Lys Met           
            475                 480                 485                   

tta agt gag gtt ctg agg gtg aag gtg ata gcc ccg gtg gat gag gtc       1722
Leu Ser Glu Val Leu Arg Val Lys Val Ile Ala Pro Val Asp Glu Val           
        490                 495                 500                       

cag att tct atc ctg tca agt aag gtg gtg gag tct gga gag gac att       1770
Gln Ile Ser Ile Leu Ser Ser Lys Val Val Glu Ser Gly Glu Asp Ile           
    505                 510                 515                           

gtg ctg caa tgt gct gtg aat gaa gga tct ggt ccc atc acc tat aag       1818
Val Leu Gln Cys Ala Val Asn Glu Gly Ser Gly Pro Ile Thr Tyr Lys           
520                 525                 530                 535           

ttt tac aga gaa aaa gag ggc aaa ccc ttc tat caa atg acc tca aat       1866
Phe Tyr Arg Glu Lys Glu Gly Lys Pro Phe Tyr Gln Met Thr Ser Asn           
                540                 545                 550               

gcc acc cag gca ttt tgg acc aag cag aag gct agc aag gaa cag gag       1914
Ala Thr Gln Ala Phe Trp Thr Lys Gln Lys Ala Ser Lys Glu Gln Glu           
            555                 560                 565                   

gga gag tat tac tgc aca gcc ttc aac aga gcc aac cac gcc tcc agt       1962
Gly Glu Tyr Tyr Cys Thr Ala Phe Asn Arg Ala Asn His Ala Ser Ser           
        570                 575                 580                       

gtc ccc aga agc aaa ata ctg aca gtc aga gtc att ctt gcc cca tgg       2010
Val Pro Arg Ser Lys Ile Leu Thr Val Arg Val Ile Leu Ala Pro Trp           
    585                 590                 595                           

aag aaa gga ctt att gca gtg gtt atc atc gga gtg atc att gct ctc       2058
Lys Lys Gly Leu Ile Ala Val Val Ile Ile Gly Val Ile Ile Ala Leu           
600                 605                 610                 615           

ttg atc att gcg gcc aaa tgt tat ttt ctg agg aaa gcc aag gcc aag       2106
Leu Ile Ile Ala Ala Lys Cys Tyr Phe Leu Arg Lys Ala Lys Ala Lys           
                620                 625                 630               

cag atg cca gtg gaa atg tcc agg cca gca gta cca ctt ctg aac tcc       2154
Gln Met Pro Val Glu Met Ser Arg Pro Ala Val Pro Leu Leu Asn Ser           
            635                 640                 645                   

aac aac gag aaa atg tca gat ccc aat atg gaa gct aac agt cat tac       2202
Asn Asn Glu Lys Met Ser Asp Pro Asn Met Glu Ala Asn Ser His Tyr           
        650                 655                 660                       

ggt cac aat gac gat gtc aga aac cat gca atg aaa cca ata aat gat       2250
Gly His Asn Asp Asp Val Arg Asn His Ala Met Lys Pro Ile Asn Asp           
    665                 670                 675                           

aat aaa gag cct ctg aac tca gac gtg cag tac acg gaa gtt caa gtg       2298
Asn Lys Glu Pro Leu Asn Ser Asp Val Gln Tyr Thr Glu Val Gln Val           
680                 685                 690                 695           

tcc tca gct gag tct cac aaa gat cta gga aag aag gac aca gag aca       2346
Ser Ser Ala Glu Ser His Lys Asp Leu Gly Lys Lys Asp Thr Glu Thr           
                700                 705                 710               

gtg tac agt gaa gtc cgg aaa gct gtc cct gat gcc gtg gaa agc aga       2394
Val Tyr Ser Glu Val Arg Lys Ala Val Pro Asp Ala Val Glu Ser Arg           
            715                 720                 725                   

tac tct aga acg gaa ggc tcc ctt gat gga act tag acagcaaggc            2440
Tyr Ser Arg Thr Glu Gly Ser Leu Asp Gly Thr                               
        730                 735                                           

cagatgcaca tccctggaag gacatccatg ttccgagaag aacagataat ccctgtattt     2500

caagacctct gtgcacttat ttatgaacct gccctgctcc cacagaacac agcaattcct     2560

caggctaagc tgccggttct taaatccatc ctgctaagtt aatgttgggt agaaagagat     2620

acagaggggc tgttgaattt cccacatacc ctccttccac caagttggaa catccttgga     2680

aattggaaga gcacaagagg agatccaggg caaggccatt gggatattct gaaacttgaa     2740

tattttgttt tgtgcagaga taaagacctt ttccatgcac cctcatacac agaaaccaat     2800

tttctttttt atactcaatc atttctagcg catggcctgg ttagaggctg gttttttctc     2860

ttttcctttg gtccttcaaa ggcttgtagt tttggctagt ccttgttctt tggaaataca     2920

cagtgctgac cagacagcct ccccctgtcc cctctatgac ctcgccctcc acaaatggga     2980

aaaccagact acttgggagc accgcctgtg aaataccaac ctgaagacac cgttcattca     3040

ggcaacgcac aaaacagaaa atgaaggtgg aacaagcaca gatgttcttc aactgttttt     3100

gtctacactc tttctctttt cctctaccat gctgaaggct gaaagacagg aagatggtgc     3160

catcagcaaa tattattctt aattgaaaac ttgaaatgtg tatgtttctt actaattttt     3220

aaaaatgtat tccttgccag ggcaggcaag gtggctcacg cctgtaatcc cagcacttca     3280

ggaggctgag gtgggcggat cacctgaggt caggagtttg agaccagcct gatgaaaccc     3340

tgtctctact aaaaatacaa gaattagccg ggcgtggtgg cgcatgcctg tagtatcagc     3400

tactcaagag gctgaggtga gattatcgct tgaacccagg aaacggaggt tgtagtgagc     3460

ggagatcgcg ccactgcact ccagcctgag tgacagagtg agaatccatc tcaaaaaaaa     3520

caaaaaacaa aattgcttgc taaagaagtg gtctcctgag gtcttaagac attcctgaca     3580

gtgtcttgag tgggtgggag agaggctgct gtcattgcgc tgtggaattt cacagatgag     3640

aaccacgcct agccaaaatc acttttcctg tttgcctcag tgacacagct gcagggaccc     3700

tcgtggatgt tgtattaaat aaatttgacc tttgctcttt gcaaaaaaaa aaaa           3754


<210>  608
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  608

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Leu Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu 
    690                 695                 700                 


Gly Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val 
705                 710                 715                 720 


Pro Asp Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp 
                725                 730                 735     


Gly Thr 
        


<210>  609
<211>  4752
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (85)..(924)

<400>  609
agtgtgcagg caggcggggg tgcgcggggc ggtcagcgat ctgcagcttc gcggggacag       60

agatgtaacc caactcgttc acgg atg ttc cgc gcg ccg tgt cac cgg ctg         111
                           Met Phe Arg Ala Pro Cys His Arg Leu            
                           1               5                              

cgg gcc agg ggt act cgg aag gcg cgg gca gga gcc tgg cga gga tgc        159
Arg Ala Arg Gly Thr Arg Lys Ala Arg Ala Gly Ala Trp Arg Gly Cys           
10                  15                  20                  25            

acc ttc ccc tgc ctt gga aag gga atg gag agg ccg gcg gcc cgg gag        207
Thr Phe Pro Cys Leu Gly Lys Gly Met Glu Arg Pro Ala Ala Arg Glu           
                30                  35                  40                

ccg cat ggg ccc gac gcg ctg cgg cgc ttc cag gga ctg ctg ctg gac        255
Pro His Gly Pro Asp Ala Leu Arg Arg Phe Gln Gly Leu Leu Leu Asp           
            45                  50                  55                    

cgc cga ggc cgg ctg cac ggc cag gtg ctg cgc ctg cgc gag gtg gcc        303
Arg Arg Gly Arg Leu His Gly Gln Val Leu Arg Leu Arg Glu Val Ala           
        60                  65                  70                        

cgg cgc ctg gag cgc ctg cgc agg cgc tcc ctc gta gcc aac gtg gcc        351
Arg Arg Leu Glu Arg Leu Arg Arg Arg Ser Leu Val Ala Asn Val Ala           
    75                  80                  85                            

ggc agc tcg ctg agc gca acg ggc gcc ctc gcc gcc atc gtg ggg ctc        399
Gly Ser Ser Leu Ser Ala Thr Gly Ala Leu Ala Ala Ile Val Gly Leu           
90                  95                  100                 105           

tcg ctc agc ccg gtc acc ctg ggg acc tcg ctg ctg gtg tcg gcc gtg        447
Ser Leu Ser Pro Val Thr Leu Gly Thr Ser Leu Leu Val Ser Ala Val           
                110                 115                 120               

ggg ctg ggg gtg gcc aca gcc gga ggg gcc gtc acc atc acg tcc gat        495
Gly Leu Gly Val Ala Thr Ala Gly Gly Ala Val Thr Ile Thr Ser Asp           
            125                 130                 135                   

ctc tcg ctg atc ttc tgc aac tcc cgg gag ctg cgg agg gtg cag gag        543
Leu Ser Leu Ile Phe Cys Asn Ser Arg Glu Leu Arg Arg Val Gln Glu           
        140                 145                 150                       

atc gcg gcc acc tgc cag gac cag atg cga gag atc ctg agc tgc ctc        591
Ile Ala Ala Thr Cys Gln Asp Gln Met Arg Glu Ile Leu Ser Cys Leu           
    155                 160                 165                           

gag ttt ttc tgc cgc tgg cag ggc tgc ggg gac cgc cag ctg ctg cag        639
Glu Phe Phe Cys Arg Trp Gln Gly Cys Gly Asp Arg Gln Leu Leu Gln           
170                 175                 180                 185           

tgc ggg agg aac gcc tcc atc gcc ctg tac aat tct gtc tac ttc atc        687
Cys Gly Arg Asn Ala Ser Ile Ala Leu Tyr Asn Ser Val Tyr Phe Ile           
                190                 195                 200               

gtc ttc ttt ggc tca cgt ggc ttc ctc atc ccc agg cgg gcg gag ggg        735
Val Phe Phe Gly Ser Arg Gly Phe Leu Ile Pro Arg Arg Ala Glu Gly           
            205                 210                 215                   

gac acc aag gtt agc cag gcc gtg ctg aag gcc aag att cag aaa ctg        783
Asp Thr Lys Val Ser Gln Ala Val Leu Lys Ala Lys Ile Gln Lys Leu           
        220                 225                 230                       

gcc gag agc ctg gag tcc tgc acc ggg gct ctg gac gaa ctc agc gag        831
Ala Glu Ser Leu Glu Ser Cys Thr Gly Ala Leu Asp Glu Leu Ser Glu           
    235                 240                 245                           

cag ctg gag tct cgg gtt cag ctc tgc acc aag tcc agt cgt ggc cac        879
Gln Leu Glu Ser Arg Val Gln Leu Cys Thr Lys Ser Ser Arg Gly His           
250                 255                 260                 265           

gac ctc aag atc tct gct gac cag cgt gca ggg ctg ttt ttc tga            924
Asp Leu Lys Ile Ser Ala Asp Gln Arg Ala Gly Leu Phe Phe                   
                270                 275                                   

gaacatcctt tccccctaat gaccgaggcc agcaaatcat cctcatggga tgctccagaa      984

tttgtagctc ccttaggaaa acaccaagct gggttaggag ccgaaggcaa aggatgagaa     1044

aaactgtttt tgaagtgggc aggtccccaa agcccttctt ttcccatcac tgtgacatct     1104

gcctgggctt gagtgctacg gacttttcag tcttcctagt ggaaaaatgt gacccaaaaa     1164

ctctttttcc tttatcaaaa actttctgtc taaacacagc tgggcaggca ctcctgtttt     1224

aaagttattt cggggtccct gaccctgccc tggtggcttg gcctgagact ggagagagtg     1284

ccatcctctg ggtcctctcc aagtcctact agtctttgaa gtcctcaaaa tgtgcgtgag     1344

gaaggcgttt gcctctattc cagaatttct gatacaaaga actccagaat ccagagcaaa     1404

tcagcccttc tctgaacgtt gtaggatggt tcagaaccca gagaggaccc tggtgctgat     1464

atctcctcct cttccctttc ccctcagctt acttactccc agatgcggcc tgggtatgaa     1524

gtaggccttt cctgagtggc tcccaatcca gtcctccaag tactcagagg ggaagcccgt     1584

gaagccgtca tctaagtcct gctccctcac atgaagctga gggccagata gatggagcga     1644

ctgccaactt catttcccga catcattgtg ttcagaagag agtgatgggt tttgagttag     1704

acagtcctgg gcttgagaca ggctttgtca ctactgtgtg agtgtagcca cctaatctct     1764

ctgagactgt gtaaaacaaa gatgataaaa tctcaccctg ttgtgagata ttaaatgagc     1824

caaagtgcct agcatgatgg tgctggctca tatagtgtag tccctggaat ggcaaattaa     1884

catcacccag gaacttgtta gaaaggcaaa ttcttggaca caaccctcct gatttatgga     1944

atcagaaact ctggctgtgg ggcccagcaa cctgagttta aacaatttct ctgggtggtt     2004

ctgcggcaca ctaaggtttg aaaatcactg caacaaatgc taacttctaa tccccttgat     2064

gagctttcac gaagtctcac ggcttctcta gggactccat ggtcttcaga gtcgttcaca     2124

gatgaccaag gacagactgt gtcccagaag ccaaaatgag agagagagag agagagcacg     2184

cgtacgtgca ccctggggca gtgtctcacc gtatgaacaa gggatgtaac actaaaagcc     2244

cattaggggg cagtgtttcc cgcctgttgt agaaactggt acagaaagga atatgaagtt     2304

cctgaaactg acctttgtct attattacct tctctgaaaa gtgccagtcc atgtattttt     2364

tatttatttt aagtttgtaa tttaattttt aattattgtt tagtgtttgc atttaatttt     2424

atttaatcac cacatttaga aaataataag agcaagtttc taaatgggag actgctgagg     2484

ctctttgcaa gagatgagat taagtttgag tttctaaggc agggcatgag ctggaaatag     2544

cattgctttc cttgattgtc tctctccttc agggagattc tttttctcta gtgttttaag     2604

tgatcctttg aagtaagtgt ggagagtctt gaatggcaag accaggagct gagtttaagc     2664

ttgtaatgga agcttgcatt gtgggatata taactgagga agcatattta tcctgaaggt     2724

attttgccag aaggtatcac ttgacctgga aaaggaatct atttagttca ggaaagataa     2784

aaagtttaga ggtatgtgaa ggaagcactt agaacttgca agcctgatgt cctatcaagt     2844

tatgtcttct gggtgacaga caaaatcgct tgtcttatgg tggtgatgtg ttgcattttc     2904

actttggggt ctgtaagaaa ctgtcagtga aaatatgtac aattccttca atttccattc     2964

ttaacaactg taatgttgaa aaataagttg aaaagtcttt gggaccatac atgcaaaaac     3024

ggtgcctctg ttacttaatt atttaatatt ctataaatgt acccaatctg tccgcaccct     3084

tcccagtgat ggggcagtat gtctgaggaa gtataatttc agtactgggg tcggggagag     3144

gaggtgatgt ttctacattt ttattttttc tataaattgc aattggtctg tatgctggtt     3204

tattttgaaa tttatattgg tttcttttca agctggtgtc atctcctaga ctgtttcacc     3264

cagatgctag catttttttt ttttttttga gacagagtct cactctgtca cctaggctgg     3324

agttgcagtg gtttgatctc ggctcactgc aacctccgac tcctgggttc aagcaattct     3384

tctgcctcag cctcctgagt agctgggatt acagatgtgc accagcacac ccggctaatt     3444

ttttgtattt ttagtagaga cagggtttcg ccatgttggc caggctggtc ttgaactcct     3504

ggccttatgt gatccgccca ccttggcttc ccaaagtgct gggattacag gcatgagcca     3564

cctcgcctgg ccagatgcta gcattttaga tcaaacaatt cattttagat gaattgtttt     3624

gtttcacaat cattttaaat cattttagaa tgtacttcac attattagtt gtgttatggc     3684

ataaaggtac aaccattccc taactccatc ttttattaat gcttaagttt aaattatatt     3744

cttccaatgc ctaagctatt ccctagaatt aaactgggca cttttggaag cagcaacagt     3804

aacagcagca gcaaactttt cctctcatat tttgggtgta tcaaaagttc tagacttttg     3864

aagttatgat ttcagtggcc cactttattt ctaaggaaga gtgtctactt tggaacgata     3924

ctttgcacat agtaggaact caagaaatac atttgaataa ttataattaa ctgtttagct     3984

atcttaatga gaatttgttg acaacaaaag atcatccatc gccttatgtg tgagtaagat     4044

tggagcctct atcaagattt agtcaagttc agttagattg attctagaaa caaatattta     4104

tttctttctt ttacggggat gtgaataagg cttttcctta aggccttcat tctttaaaca     4164

aacaggttga aatggtatgt tgtaaaagag aagacgggag agaggtattt agatgataag     4224

tgtacttcac aaaaatgcca aagtttgaaa aataggtatg tttgttctaa atgtttaagt     4284

gcttctctgt taggttctgg ggcttgcaat catttgaatt gttctgtttc acaataaagg     4344

agattcactg ggttctgcat tttcaggatt caatagaact gctccattaa aaaaataatc     4404

cttagcaagc attcgaatcc taactgcttt gatgcacttg ccctcgggca cctgtcattt     4464

ccaatatggt aggtgtcaaa gtcaaaagta tttactggga gaaaaaagag aggagtggtt     4524

gtagaagtct ccctaaatca gacatgtcaa gcaatcagcc aacgtggtgt atttctcatt     4584

caatatttta gtgtgaattg agacactgag ataaagacat cgtgcagaga taaatgggga     4644

tacagttaaa tgtagcaact cttgagttca ttttttccca ctgtagcaaa attaatgctt     4704

tctctttatt gaaataaatt gctcattcct caaaaaaaaa aaaaaaaa                  4752


<210>  610
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  610

Met Phe Arg Ala Pro Cys His Arg Leu Arg Ala Arg Gly Thr Arg Lys 
1               5                   10                  15      


Ala Arg Ala Gly Ala Trp Arg Gly Cys Thr Phe Pro Cys Leu Gly Lys 
            20                  25                  30          


Gly Met Glu Arg Pro Ala Ala Arg Glu Pro His Gly Pro Asp Ala Leu 
        35                  40                  45              


Arg Arg Phe Gln Gly Leu Leu Leu Asp Arg Arg Gly Arg Leu His Gly 
    50                  55                  60                  


Gln Val Leu Arg Leu Arg Glu Val Ala Arg Arg Leu Glu Arg Leu Arg 
65                  70                  75                  80  


Arg Arg Ser Leu Val Ala Asn Val Ala Gly Ser Ser Leu Ser Ala Thr 
                85                  90                  95      


Gly Ala Leu Ala Ala Ile Val Gly Leu Ser Leu Ser Pro Val Thr Leu 
            100                 105                 110         


Gly Thr Ser Leu Leu Val Ser Ala Val Gly Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Gly Gly Ala Val Thr Ile Thr Ser Asp Leu Ser Leu Ile Phe Cys Asn 
    130                 135                 140                 


Ser Arg Glu Leu Arg Arg Val Gln Glu Ile Ala Ala Thr Cys Gln Asp 
145                 150                 155                 160 


Gln Met Arg Glu Ile Leu Ser Cys Leu Glu Phe Phe Cys Arg Trp Gln 
                165                 170                 175     


Gly Cys Gly Asp Arg Gln Leu Leu Gln Cys Gly Arg Asn Ala Ser Ile 
            180                 185                 190         


Ala Leu Tyr Asn Ser Val Tyr Phe Ile Val Phe Phe Gly Ser Arg Gly 
        195                 200                 205             


Phe Leu Ile Pro Arg Arg Ala Glu Gly Asp Thr Lys Val Ser Gln Ala 
    210                 215                 220                 


Val Leu Lys Ala Lys Ile Gln Lys Leu Ala Glu Ser Leu Glu Ser Cys 
225                 230                 235                 240 


Thr Gly Ala Leu Asp Glu Leu Ser Glu Gln Leu Glu Ser Arg Val Gln 
                245                 250                 255     


Leu Cys Thr Lys Ser Ser Arg Gly His Asp Leu Lys Ile Ser Ala Asp 
            260                 265                 270         


Gln Arg Ala Gly Leu Phe Phe 
        275                 


<210>  611
<211>  585
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(585)

<400>  611
atg ctc tcc tcc aca ctc agg gtg gct gtg gtg tgc gtg agc aat gtc         48
Met Leu Ser Ser Thr Leu Arg Val Ala Val Val Cys Val Ser Asn Val           
1               5                   10                  15                

aac agg agc atg gag gcc cac agc atc ctc agg aga aaa ggg cta agt         96
Asn Arg Ser Met Glu Ala His Ser Ile Leu Arg Arg Lys Gly Leu Ser           
            20                  25                  30                    

gtc cgg tct ttt gga act gaa tct cat gtg agg cta cca gga cca aga        144
Val Arg Ser Phe Gly Thr Glu Ser His Val Arg Leu Pro Gly Pro Arg           
        35                  40                  45                        

ccc aat cgt cct gta gtt tac gat ttt gca aca aca tat aag gag atg        192
Pro Asn Arg Pro Val Val Tyr Asp Phe Ala Thr Thr Tyr Lys Glu Met           
    50                  55                  60                            

tac aat gac ctc ctc agg aaa gat aga gaa cgc tac acc cgc aac gga        240
Tyr Asn Asp Leu Leu Arg Lys Asp Arg Glu Arg Tyr Thr Arg Asn Gly           
65                  70                  75                  80            

atc cta cac atc ttg gga aga aat gag aga atc aag ccc ggt cca gaa        288
Ile Leu His Ile Leu Gly Arg Asn Glu Arg Ile Lys Pro Gly Pro Glu           
                85                  90                  95                

aga ttt cag gag tgc act gat ttc ttt gat gtc atc ttc acc tgt gag        336
Arg Phe Gln Glu Cys Thr Asp Phe Phe Asp Val Ile Phe Thr Cys Glu           
            100                 105                 110                   

gag agt gtc tat gac aca gtg gtg gaa gat ctg tgt tcc aga gaa cag        384
Glu Ser Val Tyr Asp Thr Val Val Glu Asp Leu Cys Ser Arg Glu Gln           
        115                 120                 125                       

cag acc ttt cag cct gtg cac gtg atc aac atg gaa atc caa gat acc        432
Gln Thr Phe Gln Pro Val His Val Ile Asn Met Glu Ile Gln Asp Thr           
    130                 135                 140                           

ctg gaa gat gcc acc ctg gga gct ttc ctc atc tgt gag att tgc cag        480
Leu Glu Asp Ala Thr Leu Gly Ala Phe Leu Ile Cys Glu Ile Cys Gln           
145                 150                 155                 160           

tgc ctg cag cag tca gac gac atg gaa gac aat ctg gaa gag ctg ctg        528
Cys Leu Gln Gln Ser Asp Asp Met Glu Asp Asn Leu Glu Glu Leu Leu           
                165                 170                 175               

ttg caa atg gag gag aag gca gga aaa agc ttt ctt cac acc gtc tgc        576
Leu Gln Met Glu Glu Lys Ala Gly Lys Ser Phe Leu His Thr Val Cys           
            180                 185                 190                   

ttc tac tga                                                            585
Phe Tyr                                                                   
                                                                          


<210>  612
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  612

Met Leu Ser Ser Thr Leu Arg Val Ala Val Val Cys Val Ser Asn Val 
1               5                   10                  15      


Asn Arg Ser Met Glu Ala His Ser Ile Leu Arg Arg Lys Gly Leu Ser 
            20                  25                  30          


Val Arg Ser Phe Gly Thr Glu Ser His Val Arg Leu Pro Gly Pro Arg 
        35                  40                  45              


Pro Asn Arg Pro Val Val Tyr Asp Phe Ala Thr Thr Tyr Lys Glu Met 
    50                  55                  60                  


Tyr Asn Asp Leu Leu Arg Lys Asp Arg Glu Arg Tyr Thr Arg Asn Gly 
65                  70                  75                  80  


Ile Leu His Ile Leu Gly Arg Asn Glu Arg Ile Lys Pro Gly Pro Glu 
                85                  90                  95      


Arg Phe Gln Glu Cys Thr Asp Phe Phe Asp Val Ile Phe Thr Cys Glu 
            100                 105                 110         


Glu Ser Val Tyr Asp Thr Val Val Glu Asp Leu Cys Ser Arg Glu Gln 
        115                 120                 125             


Gln Thr Phe Gln Pro Val His Val Ile Asn Met Glu Ile Gln Asp Thr 
    130                 135                 140                 


Leu Glu Asp Ala Thr Leu Gly Ala Phe Leu Ile Cys Glu Ile Cys Gln 
145                 150                 155                 160 


Cys Leu Gln Gln Ser Asp Asp Met Glu Asp Asn Leu Glu Glu Leu Leu 
                165                 170                 175     


Leu Gln Met Glu Glu Lys Ala Gly Lys Ser Phe Leu His Thr Val Cys 
            180                 185                 190         


Phe Tyr 
        


<210>  613
<211>  5425
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (457)..(2376)

<400>  613
ctctgtctgg gtccccacct tagtctacgg tgtcgccttt tctaactgcg agtgctaagg       60

aagaggcgag gggcgggctc cgaggctagg cgggcgctcg gggttggagc cgagggtctg      120

ggcaaaccgg tgggtccctc cccactgcgg gagcggccag ggtgggaaaa ccgcggtcgg      180

gcgggcgggg tagggccctc ccgccgccgt ggctcctggg gaggccaggg gtgaggagct      240

gtcgccgcct ttgcctctgc ctcgagggcc gcgctgaaga gactggtagg agagcgccgc      300

gggcggatgg aggcgactct tcgccccgcc tgagctcagg aggggctagc gcggagcgcg      360

ggtcccgcct ccagccgcgg gagcggccgc gcgagccacc actggaggag gaggaggagg      420

agcggacgtc ggcttctccc cgcgggagcc cccagc atg gtt gac tat att gtg        474
                                        Met Val Asp Tyr Ile Val           
                                        1               5                 

gag tat gac tat gat gct gta cat gat gat gaa tta act att cga gtt        522
Glu Tyr Asp Tyr Asp Ala Val His Asp Asp Glu Leu Thr Ile Arg Val           
            10                  15                  20                    

gga gaa atc atc agg aat gtg aaa aag cta cag gag gaa ggg tgg ctg        570
Gly Glu Ile Ile Arg Asn Val Lys Lys Leu Gln Glu Glu Gly Trp Leu           
        25                  30                  35                        

gaa gga gaa cta aat ggg aga aga gga atg ttc cct gac aat ttc gtt        618
Glu Gly Glu Leu Asn Gly Arg Arg Gly Met Phe Pro Asp Asn Phe Val           
    40                  45                  50                            

aag gaa att aaa aga gag acg gaa ttc aag gat gac agt ttg ccc atc        666
Lys Glu Ile Lys Arg Glu Thr Glu Phe Lys Asp Asp Ser Leu Pro Ile           
55                  60                  65                  70            

aaa cgg gaa agg cat ggg aat gta gca agt ctt gta caa cga ata agc        714
Lys Arg Glu Arg His Gly Asn Val Ala Ser Leu Val Gln Arg Ile Ser           
                75                  80                  85                

acc tat gga ctt cca gct gga gga att cag cca cat cca caa acc aaa        762
Thr Tyr Gly Leu Pro Ala Gly Gly Ile Gln Pro His Pro Gln Thr Lys           
            90                  95                  100                   

aac att aag aag aag acc aag aag cgt cag tgt aaa gtt ctt ttt gag        810
Asn Ile Lys Lys Lys Thr Lys Lys Arg Gln Cys Lys Val Leu Phe Glu           
        105                 110                 115                       

tac att cca caa aat gag gat gaa ctg gag ctg aaa gtg gga gat att        858
Tyr Ile Pro Gln Asn Glu Asp Glu Leu Glu Leu Lys Val Gly Asp Ile           
    120                 125                 130                           

att gat att aat gaa gag gta gaa gaa ggc tgg tgg agt gga acc ctg        906
Ile Asp Ile Asn Glu Glu Val Glu Glu Gly Trp Trp Ser Gly Thr Leu           
135                 140                 145                 150           

aat aac aag ttg gga ctg ttt ccc tca aat ttt gtg aaa gaa tta gag        954
Asn Asn Lys Leu Gly Leu Phe Pro Ser Asn Phe Val Lys Glu Leu Glu           
                155                 160                 165               

gta aca gat gat ggt gaa act cat gaa gcc cag gac gat tca gaa act       1002
Val Thr Asp Asp Gly Glu Thr His Glu Ala Gln Asp Asp Ser Glu Thr           
            170                 175                 180                   

gtt ttg gct ggg cct act tca cct ata cct tct ctg gga aat gtg agt       1050
Val Leu Ala Gly Pro Thr Ser Pro Ile Pro Ser Leu Gly Asn Val Ser           
        185                 190                 195                       

gaa act gca tct gga tca gtt aca cag cca aag aaa att cga gga att       1098
Glu Thr Ala Ser Gly Ser Val Thr Gln Pro Lys Lys Ile Arg Gly Ile           
    200                 205                 210                           

gga ttt gga gac att ttt aaa gaa ggc tct gtg aaa ctt cgg aca aga       1146
Gly Phe Gly Asp Ile Phe Lys Glu Gly Ser Val Lys Leu Arg Thr Arg           
215                 220                 225                 230           

aca tcc agt agt gaa aca gaa gag aaa aaa cca gaa aag ccc tta atc       1194
Thr Ser Ser Ser Glu Thr Glu Glu Lys Lys Pro Glu Lys Pro Leu Ile           
                235                 240                 245               

cta cag tca ctg gga ccc aaa act cag agt gtg gag ata aca aaa aca       1242
Leu Gln Ser Leu Gly Pro Lys Thr Gln Ser Val Glu Ile Thr Lys Thr           
            250                 255                 260                   

gat acc gaa ggt aaa att aaa gct aaa gaa tat tgt aga aca tta ttt       1290
Asp Thr Glu Gly Lys Ile Lys Ala Lys Glu Tyr Cys Arg Thr Leu Phe           
        265                 270                 275                       

gcc tat gaa ggt act aat gaa gat gaa ctt act ttt aaa gag ggg gag       1338
Ala Tyr Glu Gly Thr Asn Glu Asp Glu Leu Thr Phe Lys Glu Gly Glu           
    280                 285                 290                           

ata atc cat ttg ata agt aag gag act gga gaa gct ggc tgg tgg agg       1386
Ile Ile His Leu Ile Ser Lys Glu Thr Gly Glu Ala Gly Trp Trp Arg           
295                 300                 305                 310           

ggc gaa ctt aat ggt aaa gaa gga gta ttt cca gac aat ttt gct gtc       1434
Gly Glu Leu Asn Gly Lys Glu Gly Val Phe Pro Asp Asn Phe Ala Val           
                315                 320                 325               

cag ata aat gaa ctt gat aaa gac ttt cca aaa cca aag aaa cca cca       1482
Gln Ile Asn Glu Leu Asp Lys Asp Phe Pro Lys Pro Lys Lys Pro Pro           
            330                 335                 340                   

cct cct gct aag gct cca gct cca aag cct gaa ctg ata gct gca gag       1530
Pro Pro Ala Lys Ala Pro Ala Pro Lys Pro Glu Leu Ile Ala Ala Glu           
        345                 350                 355                       

aag aaa tat ttt tct tta aag cct gaa gaa aag gat gaa aaa tca aca       1578
Lys Lys Tyr Phe Ser Leu Lys Pro Glu Glu Lys Asp Glu Lys Ser Thr           
    360                 365                 370                           

ctg gaa cag aaa cct tct aaa cca gca gct cca caa gtc cca ccc aag       1626
Leu Glu Gln Lys Pro Ser Lys Pro Ala Ala Pro Gln Val Pro Pro Lys           
375                 380                 385                 390           

aaa cct act cca cct acc aaa gcc agt aat tta ctg aga tct tct gga       1674
Lys Pro Thr Pro Pro Thr Lys Ala Ser Asn Leu Leu Arg Ser Ser Gly           
                395                 400                 405               

aca gtg tac cca aag cga cct gaa aaa cca gtt cct cca cca cct cct       1722
Thr Val Tyr Pro Lys Arg Pro Glu Lys Pro Val Pro Pro Pro Pro Pro           
            410                 415                 420                   

ata gcc aag att aat ggg gaa gtt tct agc att tca tca aaa ttt gaa       1770
Ile Ala Lys Ile Asn Gly Glu Val Ser Ser Ile Ser Ser Lys Phe Glu           
        425                 430                 435                       

act gag cca gta tca aaa cta aag cta gat tct gaa cag ctg ccc ctt       1818
Thr Glu Pro Val Ser Lys Leu Lys Leu Asp Ser Glu Gln Leu Pro Leu           
    440                 445                 450                           

aga cca aaa tca gta gac ttt gat tca ctt aca gta agg acc tcc aaa       1866
Arg Pro Lys Ser Val Asp Phe Asp Ser Leu Thr Val Arg Thr Ser Lys           
455                 460                 465                 470           

gaa aca gat gtt gta aat ttt gat gac ata gct tcc tca gaa aac ttg       1914
Glu Thr Asp Val Val Asn Phe Asp Asp Ile Ala Ser Ser Glu Asn Leu           
                475                 480                 485               

ctt cat ctc act gca aat aga cca aag atg cct gga aga agg ttg ccg       1962
Leu His Leu Thr Ala Asn Arg Pro Lys Met Pro Gly Arg Arg Leu Pro           
            490                 495                 500                   

ggc cgt ttc aat ggt gga cat tct cca act cac agc ccc gaa aaa atc       2010
Gly Arg Phe Asn Gly Gly His Ser Pro Thr His Ser Pro Glu Lys Ile           
        505                 510                 515                       

ttg aag tta cca aaa gaa gaa gac agt gcc aac ctg aag cca tct gaa       2058
Leu Lys Leu Pro Lys Glu Glu Asp Ser Ala Asn Leu Lys Pro Ser Glu           
    520                 525                 530                           

tta aaa aaa gat aca tgc tac tct cca aag cca tct gtg tac ctt tca       2106
Leu Lys Lys Asp Thr Cys Tyr Ser Pro Lys Pro Ser Val Tyr Leu Ser           
535                 540                 545                 550           

aca cct tcc agt gct tct aaa gca aat aca act gct ttc ctg act cca       2154
Thr Pro Ser Ser Ala Ser Lys Ala Asn Thr Thr Ala Phe Leu Thr Pro           
                555                 560                 565               

tta gaa atc aaa gct aaa gtg gaa aca gat gat gtg aaa aaa aat tcc       2202
Leu Glu Ile Lys Ala Lys Val Glu Thr Asp Asp Val Lys Lys Asn Ser           
            570                 575                 580                   

ctg gat gaa ctt aga gcc cag att att gaa ttg ttg tgc att gta gaa       2250
Leu Asp Glu Leu Arg Ala Gln Ile Ile Glu Leu Leu Cys Ile Val Glu           
        585                 590                 595                       

gca ctg aaa aag gat cac ggg aaa gaa ctg gaa aaa ctg cga aaa gat       2298
Ala Leu Lys Lys Asp His Gly Lys Glu Leu Glu Lys Leu Arg Lys Asp           
    600                 605                 610                           

ttg gaa gaa gag aag aca atg aga agt aat cta gag atg gaa ata gag       2346
Leu Glu Glu Glu Lys Thr Met Arg Ser Asn Leu Glu Met Glu Ile Glu           
615                 620                 625                 630           

aag ctg aaa aaa gct gtc ctg tct tct tga gtggtgtgga cctggtgttc         2396
Lys Leu Lys Lys Ala Val Leu Ser Ser                                       
                635                                                       

ataatgttcc agggattcag aagcaacgct atgaacttca gctgacttgt tacttaaaaa     2456

ttgtgaattc tgttgttgtg ataaatatga gcaaatgaag tgtaatatct atagaaaagt     2516

agagtgaggg tgaatttata tatatatttt gttttgccaa tatgaagaaa aagaggcctt     2576

atttcttaac tgtgctggga ttgcaaacac tttttaaaaa attgtttgct tgaaaatact     2636

actgaatata aataagaatg tgcacagtag tttttttatt gaaacttgta ttatttttaa     2696

agagatctat actataaata tggtgatata tttacaagta atctgttaag atatactatt     2756

tgagagggac agattagcct tttagtaact atagtcacta ctttttccat aatgcataag     2816

ggatataaac tctgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtatata     2876

tatatatata tttttacttt tatcctctta ccgaaggtta cactgttgtg cctgtttgtc     2936

tgcaatgctg tttatatttt gggtgatgaa ataggagttt cctagctata taaaccagat     2996

tactcaccca tgcatatagt aagaactaat gaataatcaa aataatttca tcaactttta     3056

gaatatttta tgttgcttgc actataggag tcataaaagg aacttagtta aaatatgttg     3116

gattgttaaa catttgggga aatatgaact gtattttaaa tttgttaggt ctgaagaatc     3176

taaaactgtt aatttaaccc ttaacttgtg cctagaaact acagcacata taaaatatgt     3236

aaacaccagc ctgttgctgt acttttctgc ttattttaca gcctcaaata tttctcatta     3296

tcttgtcact tagttcttca tgtttctcct tctgactttt aataatggta ataggaaaac     3356

aaaacccaaa gcttttcaga acttcagtgt gaggtttcct attttgacaa gttaacttgt     3416

aaatactcag gttttacgat gtataattta cctaatagac caaactaact catggagata     3476

ttttgaacta ttatttaggt acaaacttta taaagaatgt tagtatgtca taaaatataa     3536

cattacagct tatttaaaac caaatatagt tgaacatatt taaaatacat tttcacagaa     3596

tggatgaatt agttgtttct tcagagttac ttatgaacag ttgaatgctt taaaatgttc     3656

tgtctgtagg taacatctaa aacacaagtg ggtttattta aatttttaaa atttgaaatt     3716

ttttatttgc aaaaaattgt tttatgcttt attatatcgc aaatgagtgt cagatttttg     3776

agtaccaatg atcatgcttc catttttttt agttttaaac caccaaacca atatttttcc     3836

tttaaatttt aatcttataa tatagaaatc ttatgtaaat gaaattttgt catgtttcaa     3896

ataaagagaa ctgaagtaga aaatagaaat gccagtaaac aacataatgt ttaatttaca     3956

acttacatta ggggtttggg ggaatgctaa ttatatattg agaatataca ttagaactct     4016

tcaaaatggg ctcttctaat gaggtcacta ctgaacaaaa ttgttccctc ttctgttaaa     4076

tagaataggt ttaaatgact agtcaaatga attattttct tcttgttaaa taaattaaat     4136

cttactttct tttaatgacc aaccttaggt aaaacaaaaa tattgtaatc ctagaaatta     4196

tcctccagct ttctcacctg aaaatctatt gaagtgatcc ctggtcatcc taataatggg     4256

atgagggaag tttccagcag atttcaggct gttcttaaag tttttgttgg tcattttctc     4316

aatagtacat gaaatcaaga tgcttatgag catggaaatg tatttaaagt ttttgcttgt     4376

gtcctcctca gtcagaatag aaaagtaact gaaatacttt tacctttctg tccttgataa     4436

aatagtaaag aaaaccaaac aaacccaggc ctgatgggaa aaatgattcc tttattctag     4496

caacttactt tctgttggta tgggaaatgt tattaatttc tattactaaa gttcatatca     4556

caaaatgata tttaataata accttggggt aaatcatgaa ttttttttct acgtgtgagt     4616

ataaaagaca aaagttgaac agcatggaat ctcattgcca aattattagt gaatgtatag     4676

ttcaggtatt ctttgagaca cacagtatca ttaatttctg aattgtattt cagtgttatt     4736

ttttgtttgt gaccactaag cttctgtctt aatacaaagc tgttaccttc tacagaattt     4796

aagtctgaag atgtaaagag agaacaggcc ttgtgtaaca gaagatactc ttttttatgc     4856

tccttactgt gatcacagaa aaattaaaaa tccaagtgct ctctagattt gttgataaac     4916

attttatgct tgcatttaaa cttgaaatgt atgagcagaa tgagacaatc agttaaatca     4976

gaaatgagaa gtattataat gtaaaggcct tgttttgctg tagcaataaa atgaccaagt     5036

gcaatgactt gatttaataa aatcatattt taaaagttgc tgctatgaat atttttggct     5096

ataaaatttt accctgactt gctttcaata actgttacgt aatgcagttg atgttgtaac     5156

ctaacattcc aaaaaaaaaa ttgagagggg gaatctcaaa atagtatata cttcactaac     5216

ttgtttacag gtgctgtatt taaaagcatg cttctctctc aaaaagaaaa attaaaggat     5276

tttattgcca gtcgtgtcag tctttattgg ttattttttg ttaactttag catttgtgta     5336

tttcagagta tgatgaaaat tatattactt caatttccaa atacaagaat aaatagtaaa     5396

ccaaaaacat taaaaaaaaa aaaaaaaaa                                       5425


<210>  614
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  614

Met Val Asp Tyr Ile Val Glu Tyr Asp Tyr Asp Ala Val His Asp Asp 
1               5                   10                  15      


Glu Leu Thr Ile Arg Val Gly Glu Ile Ile Arg Asn Val Lys Lys Leu 
            20                  25                  30          


Gln Glu Glu Gly Trp Leu Glu Gly Glu Leu Asn Gly Arg Arg Gly Met 
        35                  40                  45              


Phe Pro Asp Asn Phe Val Lys Glu Ile Lys Arg Glu Thr Glu Phe Lys 
    50                  55                  60                  


Asp Asp Ser Leu Pro Ile Lys Arg Glu Arg His Gly Asn Val Ala Ser 
65                  70                  75                  80  


Leu Val Gln Arg Ile Ser Thr Tyr Gly Leu Pro Ala Gly Gly Ile Gln 
                85                  90                  95      


Pro His Pro Gln Thr Lys Asn Ile Lys Lys Lys Thr Lys Lys Arg Gln 
            100                 105                 110         


Cys Lys Val Leu Phe Glu Tyr Ile Pro Gln Asn Glu Asp Glu Leu Glu 
        115                 120                 125             


Leu Lys Val Gly Asp Ile Ile Asp Ile Asn Glu Glu Val Glu Glu Gly 
    130                 135                 140                 


Trp Trp Ser Gly Thr Leu Asn Asn Lys Leu Gly Leu Phe Pro Ser Asn 
145                 150                 155                 160 


Phe Val Lys Glu Leu Glu Val Thr Asp Asp Gly Glu Thr His Glu Ala 
                165                 170                 175     


Gln Asp Asp Ser Glu Thr Val Leu Ala Gly Pro Thr Ser Pro Ile Pro 
            180                 185                 190         


Ser Leu Gly Asn Val Ser Glu Thr Ala Ser Gly Ser Val Thr Gln Pro 
        195                 200                 205             


Lys Lys Ile Arg Gly Ile Gly Phe Gly Asp Ile Phe Lys Glu Gly Ser 
    210                 215                 220                 


Val Lys Leu Arg Thr Arg Thr Ser Ser Ser Glu Thr Glu Glu Lys Lys 
225                 230                 235                 240 


Pro Glu Lys Pro Leu Ile Leu Gln Ser Leu Gly Pro Lys Thr Gln Ser 
                245                 250                 255     


Val Glu Ile Thr Lys Thr Asp Thr Glu Gly Lys Ile Lys Ala Lys Glu 
            260                 265                 270         


Tyr Cys Arg Thr Leu Phe Ala Tyr Glu Gly Thr Asn Glu Asp Glu Leu 
        275                 280                 285             


Thr Phe Lys Glu Gly Glu Ile Ile His Leu Ile Ser Lys Glu Thr Gly 
    290                 295                 300                 


Glu Ala Gly Trp Trp Arg Gly Glu Leu Asn Gly Lys Glu Gly Val Phe 
305                 310                 315                 320 


Pro Asp Asn Phe Ala Val Gln Ile Asn Glu Leu Asp Lys Asp Phe Pro 
                325                 330                 335     


Lys Pro Lys Lys Pro Pro Pro Pro Ala Lys Ala Pro Ala Pro Lys Pro 
            340                 345                 350         


Glu Leu Ile Ala Ala Glu Lys Lys Tyr Phe Ser Leu Lys Pro Glu Glu 
        355                 360                 365             


Lys Asp Glu Lys Ser Thr Leu Glu Gln Lys Pro Ser Lys Pro Ala Ala 
    370                 375                 380                 


Pro Gln Val Pro Pro Lys Lys Pro Thr Pro Pro Thr Lys Ala Ser Asn 
385                 390                 395                 400 


Leu Leu Arg Ser Ser Gly Thr Val Tyr Pro Lys Arg Pro Glu Lys Pro 
                405                 410                 415     


Val Pro Pro Pro Pro Pro Ile Ala Lys Ile Asn Gly Glu Val Ser Ser 
            420                 425                 430         


Ile Ser Ser Lys Phe Glu Thr Glu Pro Val Ser Lys Leu Lys Leu Asp 
        435                 440                 445             


Ser Glu Gln Leu Pro Leu Arg Pro Lys Ser Val Asp Phe Asp Ser Leu 
    450                 455                 460                 


Thr Val Arg Thr Ser Lys Glu Thr Asp Val Val Asn Phe Asp Asp Ile 
465                 470                 475                 480 


Ala Ser Ser Glu Asn Leu Leu His Leu Thr Ala Asn Arg Pro Lys Met 
                485                 490                 495     


Pro Gly Arg Arg Leu Pro Gly Arg Phe Asn Gly Gly His Ser Pro Thr 
            500                 505                 510         


His Ser Pro Glu Lys Ile Leu Lys Leu Pro Lys Glu Glu Asp Ser Ala 
        515                 520                 525             


Asn Leu Lys Pro Ser Glu Leu Lys Lys Asp Thr Cys Tyr Ser Pro Lys 
    530                 535                 540                 


Pro Ser Val Tyr Leu Ser Thr Pro Ser Ser Ala Ser Lys Ala Asn Thr 
545                 550                 555                 560 


Thr Ala Phe Leu Thr Pro Leu Glu Ile Lys Ala Lys Val Glu Thr Asp 
                565                 570                 575     


Asp Val Lys Lys Asn Ser Leu Asp Glu Leu Arg Ala Gln Ile Ile Glu 
            580                 585                 590         


Leu Leu Cys Ile Val Glu Ala Leu Lys Lys Asp His Gly Lys Glu Leu 
        595                 600                 605             


Glu Lys Leu Arg Lys Asp Leu Glu Glu Glu Lys Thr Met Arg Ser Asn 
    610                 615                 620                 


Leu Glu Met Glu Ile Glu Lys Leu Lys Lys Ala Val Leu Ser Ser 
625                 630                 635                 


<210>  615
<211>  4814
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (190)..(849)

<400>  615
ctgttaaggt atacagacag tagttaaata gcagggccaa ctattctgtt aagggtcttc       60

ctagacagac taaaaaagcc atgtattctt tcgtttctct ctaaaagaag aaaaatataa      120

tttaaaaata cattgcgtat tttctaaaac aataaattta tagtgttaat attcataggg      180

tcaatcaaa atg aag ctt ctc ctt tgg gcc tgc att gta tgt gtt gct ttt      231
          Met Lys Leu Leu Leu Trp Ala Cys Ile Val Cys Val Ala Phe         
          1               5                   10                          

gca agg aag aga cgg ttc ccc ttc att ggt gag gat gac aat gac gat        279
Ala Arg Lys Arg Arg Phe Pro Phe Ile Gly Glu Asp Asp Asn Asp Asp           
15                  20                  25                  30            

ggt cac cca ctt cat cca tct ctg aat att cct tat ggc ata cgg aat        327
Gly His Pro Leu His Pro Ser Leu Asn Ile Pro Tyr Gly Ile Arg Asn           
                35                  40                  45                

tta cca cct cct ctt tat tat cgc cca gtg aat aca gtc ccc agt tac        375
Leu Pro Pro Pro Leu Tyr Tyr Arg Pro Val Asn Thr Val Pro Ser Tyr           
            50                  55                  60                    

cct ggg aat act tac act gac aca ggg tta cct tcg tat ccc tgg att        423
Pro Gly Asn Thr Tyr Thr Asp Thr Gly Leu Pro Ser Tyr Pro Trp Ile           
        65                  70                  75                        

cta act tct cct gga ttc ccc tat gtc tat cac atc cgt ggt ttt ccc        471
Leu Thr Ser Pro Gly Phe Pro Tyr Val Tyr His Ile Arg Gly Phe Pro           
    80                  85                  90                            

tta gct act cag ttg aat gtt cct cct ctc cct cct agg ggt ttc ccg        519
Leu Ala Thr Gln Leu Asn Val Pro Pro Leu Pro Pro Arg Gly Phe Pro           
95                  100                 105                 110           

ttt gtc cct cct tca agg ttt ttt tca gca gct gca gca ccc gct gcc        567
Phe Val Pro Pro Ser Arg Phe Phe Ser Ala Ala Ala Ala Pro Ala Ala           
                115                 120                 125               

cca cct att gca gct gag cct gct gca gct gca cct ctt aca gcc aca        615
Pro Pro Ile Ala Ala Glu Pro Ala Ala Ala Ala Pro Leu Thr Ala Thr           
            130                 135                 140                   

cct gta gca gct gag cct gct gca ggg gcc cct gtt gca gct gag cct        663
Pro Val Ala Ala Glu Pro Ala Ala Gly Ala Pro Val Ala Ala Glu Pro           
        145                 150                 155                       

gct gca gag gca cct gtt gga gct gag cct gct gca gag gca cct gtt        711
Ala Ala Glu Ala Pro Val Gly Ala Glu Pro Ala Ala Glu Ala Pro Val           
    160                 165                 170                           

gca gct gag cct gct gca gag gca cct gtt gga gtg gag cca gct gca        759
Ala Ala Glu Pro Ala Ala Glu Ala Pro Val Gly Val Glu Pro Ala Ala           
175                 180                 185                 190           

gag gaa cct tca cca gct gag cct gct aca gcc aag cct gct gcc cca        807
Glu Glu Pro Ser Pro Ala Glu Pro Ala Thr Ala Lys Pro Ala Ala Pro           
                195                 200                 205               

gaa cct cac cct tct ccc tct ctt gaa cag gca aat cag tga                849
Glu Pro His Pro Ser Pro Ser Leu Glu Gln Ala Asn Gln                       
            210                 215                                       

aattctctag aagagtacca tgggttcatt tctatactga tgcagaaata agtgaaatct      909

acaaaagttt tctttctttt ccaaagacta tttcattctg ttgtattcag agtattcatc      969

tcactacatt gatttgtttg tggtagtttt tccttggact taatttatat tgaaaaaaca     1029

ttgataatta aataaataaa atagataatt tagaccaatg gtgataaggt ctggatgaaa     1089

actacgctat ggaggactga aatggcaatc attcagccta gcctggagtc tgattataca     1149

gctactatag gatgatgtta gtattggttt tgagtgcaat aggttttttc ctaaacaaac     1209

atattttgta gtcaatgaac tttttgtcac aaaacagtaa aacatctgtg tttaacctat     1269

ggtaaacaac atgttaatga actatgctat ccatgactta atggacagtt caaatgtgac     1329

atctacagtt tttcatttct cttttatgcc agcacacaat caattcatca ccaattgtca     1389

tttgatttac ttcaaaaaat atacccccaa atcctaatac ttctaacctt ctccactgca     1449

tctagccaac tctagctatt gtcatcccta acagaaatgg aggaatagcc tctttttttt     1509

tttttttttt tgagacgaag tctcacactg ttgcacggct gtagtgcaat ggtgccaact     1569

cagctcactg caacttccac ctcccgggtt caagtgattc tcctgcctca gcctcctgag     1629

tagccgggat tacaggtgtg tgccaccacg cctggctaat tttttgtaat ttagtacaga     1689

caggggttcc ctatgttggc caggatggtc ttgatctcct gacctcatga tctgtccgcc     1749

tcggcctccc aaagtgctgg gaatacaggc gtgagccacc gtgccctgcc agaatagcct     1809

attaaccagt ctacctgctt ccacttttcc tccaccctga tcacatacac acatgcatta     1869

tccactgagc agtcacaatc agatgttaaa ccaaacatta ttcagataag atctctgaaa     1929

agcctctgat actttctctt ttaaaatgga atatattcta aacacctctc caaggacaca     1989

agacttacct tgtctaacta atgacttttc taacttcatt ccctatcatt ctccatcttg     2049

ccccatgctc ctcatgcagc agcttttttt tttttttcct ttttcaaata tgttggtttt     2109

gatcttatcc aagaaccttt gccctgatgt atgaatgact aactgctttt ctacttcggg     2169

ggtctcatat agaaatcctg cttcagaata ctcttccctg agcactctat ctaaataaat     2229

ccctcttctg caacccagtg ctttttgttc tattactgac ttcttttcct tgtagaagtt     2289

actattactg ctttttacct ttttatttat ttgtgtattg tctttgttgt tgccctcatc     2349

ttatctccac aaaaatatat gctccataaa aacaggcatt tctgtgtctt attcagcact     2409

ttatcagggc ctataacaat gcctgggaca tattcagtga ccagtgaata tttttggaag     2469

gaaagaaaag aagaaagaat gaagtaacaa acaaagaatg aaggaagaaa aaatttttac     2529

aaacattcaa catattttta ttttgaaata attttgtatt tttccctata tcctacattg     2589

gatcagaata ttactgttat gtatagccat gaggacatgg tctcaaaaaa tgagaaactt     2649

tcttagacag taaaattgtt aacttgagat gtttgcttcc atcttctaga gccaagtagg     2709

atctaacttt aatttgactt agccaataat ctgaaactat tatagtatct gtctttcaca     2769

gatacatgca atattcactt ctaaatattt aatgataaat ttgtaatcat acatgatagt     2829

caattttaat gattatgttg tcaaaattca ggctttttgt gtgaattgaa gacttaaaga     2889

agaatttgta aatatgactg tataagaaac aacagaaaga tgaagatgaa ccgaaataga     2949

aatatcaaga ggctacaaag tcttagcaaa ttataattgc taatggtaca ttatgtggtg     3009

tttagtatca catttagaat gtagtcattt gttaagtttt tcatggggta aaagaaagaa     3069

tttattccaa gaaaattttg gaattttaaa aataaacatg acatcttatc atgagaaaca     3129

tttacagttt ttgcttttac tacaagatac tgtgaaatgt tctgctctgt cagttgtgaa     3189

agtatgaaat ttaagtctat cactacaata atattttgtt tttagtgttc atttttttcc     3249

tcctgactac attgagatga gttagattga gtgaaaggta aacactaaca tttgaattga     3309

ggtaatttcc actgtggaaa acaaactgtt gttagtaaac aggcatcagc tttgagacac     3369

agaaaagtca tccaaaccag aagattggga acttcctcaa ttactttgtc ttccatttat     3429

tgcattcaat tagtcaaaaa tgttgttaat tatacatttt aaagactatt tttggtaagg     3489

tctatgacac attcaaaata ctacatacaa gtttgtatta tcataaataa tccaaaagaa     3549

aacatacatg taaccaccac catctggaaa tttcacacta aattataaaa catttccatc     3609

actgcatgta ttgtttaatg tcgctttatg aatccacctt cttccttatc tgtagagtta     3669

aaaactactt agtggattag ggtaattcat tctactttta aaaatgattt ttccacctct     3729

aatgtattct ataaaataat attgttcact tttgcctatt tttgagcttt ttatagaaaa     3789

atgctactgc gaaattattt tgagtcatat cttttgatcg atattaagat acatttgcag     3849

agttttgtat gtgtgtttat atccatctta cataattctt tactgtatag cgttcccttt     3909

agccactgga aaatgatata atgtcattgc ttacagaagg tgactgattc ttattcagtg     3969

ctactttcta cagacaggta actattcgca tttacgatta agaaatgttc acaccttcac     4029

actggtatca actgcaacaa ccactatact tctccagtga ttgccagatg gcccactata     4089

catcctttct tctatttctt tcttttgtgg ccagaaagtc aggacctcaa agaggtataa     4149

gtttgtgtgt ataattccct ggcttttttc taaaatttta gtatgcattt atgtggcact     4209

taatatataa aagagtttta tgagttttaa aaatgtatat aaacaagaca tataataaat     4269

ggtatgtcat ttcacaattt actattttta ctcaacattt atatttctga gacttttcac     4329

atttttgaat gtattcatag tttcacttta attgatgttt gccatgaaag atcaaatata     4389

tcacatttta tttgactaaa aagtaaacta tatttcctac attatgctat agaacttata     4449

gactaattta agttaattat aggccttatc tcagaccttt gcaagtagcc tgaataaaac     4509

ttttcattat ttatattatc acatgcatat atgtgtgtat gtatatatgt gtgcatgtgc     4569

atgcatagta aaaatcttaa cccaaaactg aaataaaaaa ttataagaga aaatactatt     4629

ttccaccaat atcacaatgg ataatctttt ttaaatgact acatatgtcg ataagttaca     4689

aaatccatat atgagtatga caccaataag aacattttct ctaaccattt tgaatacgaa     4749

taaccatgga ttctaatagc aaacattatt aaaatattat tgaaataaaa aaaaaaaaaa     4809

aaaaa                                                                 4814


<210>  616
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  616

Met Lys Leu Leu Leu Trp Ala Cys Ile Val Cys Val Ala Phe Ala Arg 
1               5                   10                  15      


Lys Arg Arg Phe Pro Phe Ile Gly Glu Asp Asp Asn Asp Asp Gly His 
            20                  25                  30          


Pro Leu His Pro Ser Leu Asn Ile Pro Tyr Gly Ile Arg Asn Leu Pro 
        35                  40                  45              


Pro Pro Leu Tyr Tyr Arg Pro Val Asn Thr Val Pro Ser Tyr Pro Gly 
    50                  55                  60                  


Asn Thr Tyr Thr Asp Thr Gly Leu Pro Ser Tyr Pro Trp Ile Leu Thr 
65                  70                  75                  80  


Ser Pro Gly Phe Pro Tyr Val Tyr His Ile Arg Gly Phe Pro Leu Ala 
                85                  90                  95      


Thr Gln Leu Asn Val Pro Pro Leu Pro Pro Arg Gly Phe Pro Phe Val 
            100                 105                 110         


Pro Pro Ser Arg Phe Phe Ser Ala Ala Ala Ala Pro Ala Ala Pro Pro 
        115                 120                 125             


Ile Ala Ala Glu Pro Ala Ala Ala Ala Pro Leu Thr Ala Thr Pro Val 
    130                 135                 140                 


Ala Ala Glu Pro Ala Ala Gly Ala Pro Val Ala Ala Glu Pro Ala Ala 
145                 150                 155                 160 


Glu Ala Pro Val Gly Ala Glu Pro Ala Ala Glu Ala Pro Val Ala Ala 
                165                 170                 175     


Glu Pro Ala Ala Glu Ala Pro Val Gly Val Glu Pro Ala Ala Glu Glu 
            180                 185                 190         


Pro Ser Pro Ala Glu Pro Ala Thr Ala Lys Pro Ala Ala Pro Glu Pro 
        195                 200                 205             


His Pro Ser Pro Ser Leu Glu Gln Ala Asn Gln 
    210                 215                 


<210>  617
<211>  2421
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2421)

<400>  617
agc ggc ccc cga gtc agc ccc gcg cca gga gcc gga gag acg cgc cct         48
Ser Gly Pro Arg Val Ser Pro Ala Pro Gly Ala Gly Glu Thr Arg Pro           
1               5                   10                  15                

ccg cct cct ccc acc caa gcc tcg cgc agt ccc ggg ggc ggg gcg ggg         96
Pro Pro Pro Pro Thr Gln Ala Ser Arg Ser Pro Gly Gly Gly Ala Gly           
            20                  25                  30                    

cca gct gag gga gga agg ggc ggg gac ccg ggg cct cta ccc gtt agg        144
Pro Ala Glu Gly Gly Arg Gly Gly Asp Pro Gly Pro Leu Pro Val Arg           
        35                  40                  45                        

ctg ccg ttg gtc ccg aga ctc ccc cat ctg cgc ccc cgc cct gcc ctg        192
Leu Pro Leu Val Pro Arg Leu Pro His Leu Arg Pro Arg Pro Ala Leu           
    50                  55                  60                            

cga ggc cgc cgc cgc gcg ccc cac cgt ctg ttg cag tgg agc gtg agc        240
Arg Gly Arg Arg Arg Ala Pro His Arg Leu Leu Gln Trp Ser Val Ser           
65                  70                  75                  80            

cgc ggc tgc ggc tcc tgg ttc ttg tgg aag gac agc aag gct gag gag        288
Arg Gly Cys Gly Ser Trp Phe Leu Trp Lys Asp Ser Lys Ala Glu Glu           
                85                  90                  95                

aat ggc tcc cac agc ttc atg cac tcc atg gac cca cag ctg gag cgg        336
Asn Gly Ser His Ser Phe Met His Ser Met Asp Pro Gln Leu Glu Arg           
            100                 105                 110                   

caa atg gaa acc acc cag aac ctg gtg gac tcc tac atg gcc att gtc        384
Gln Met Glu Thr Thr Gln Asn Leu Val Asp Ser Tyr Met Ala Ile Val           
        115                 120                 125                       

aac aag acc gtg tgg aac ctc atg gtt ggt gcg aag ccc aag acc atc        432
Asn Lys Thr Val Trp Asn Leu Met Val Gly Ala Lys Pro Lys Thr Ile           
    130                 135                 140                           

atg cac atc atg atc tac aat gtg cat gca ccg cct cat ggg gac caa        480
Met His Ile Met Ile Tyr Asn Val His Ala Pro Pro His Gly Asp Gln           
145                 150                 155                 160           

gga gtt cat ctt ctc aga gct gct gtc caa cct gta ctc gcg tgg gaa        528
Gly Val His Leu Leu Arg Ala Ala Val Gln Pro Val Leu Ala Trp Glu           
                165                 170                 175               

caa gga gac act cct gga gga gtc ggc aga gca ggc aca gcg gcg cga        576
Gln Gly Asp Thr Pro Gly Gly Val Gly Arg Ala Gly Thr Ala Ala Arg           
            180                 185                 190                   

cga gat gct gct tct cag agc tgc tgt cca acc tgc act cgc gtg gga        624
Arg Asp Ala Ala Ser Gln Ser Cys Cys Pro Thr Cys Thr Arg Val Gly           
        195                 200                 205                       

acg aga aga cac tcg tgg agg cgt cgg cag agc agg cac caa act gca        672
Thr Arg Arg His Ser Trp Arg Arg Arg Gln Ser Arg His Gln Thr Ala           
    210                 215                 220                           

ctt gcg tgg gaa cga gaa gac act cat gga gga gtc ggc aga gca ggc        720
Leu Ala Trp Glu Arg Glu Asp Thr His Gly Gly Val Gly Arg Ala Gly           
225                 230                 235                 240           

aca gcg gtg cga cga gac tcg cgt ggg aac gag aag aca ctc gtg gag        768
Thr Ala Val Arg Arg Asp Ser Arg Gly Asn Glu Lys Thr Leu Val Glu           
                245                 250                 255               

gcg tcg gca gag cag gca gac caa gga gtt cat ctt ctc aga gct gct        816
Ala Ser Ala Glu Gln Ala Asp Gln Gly Val His Leu Leu Arg Ala Ala           
            260                 265                 270                   

gtc caa cct gca ctc gcg tgg gaa cga gaa gac act cgt gga ggc gtc        864
Val Gln Pro Ala Leu Ala Trp Glu Arg Glu Asp Thr Arg Gly Gly Val           
        275                 280                 285                       

ggc aga gca ggc aga cca agg agt tca tct tct cag agc ttc tgt cca        912
Gly Arg Ala Gly Arg Pro Arg Ser Ser Ser Ser Gln Ser Phe Cys Pro           
    290                 295                 300                           

acc tgt act cgc gtg gga acg aga aga cac tcg tgg agg cgt cgg cag        960
Thr Cys Thr Arg Val Gly Thr Arg Arg His Ser Trp Arg Arg Arg Gln           
305                 310                 315                 320           

agc agg cag acc aag gag ttc atc ttc tca gag ctg ctg tcc aac ctg       1008
Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu Ser Asn Leu           
                325                 330                 335               

tac tcg cgt ggg aac gag aag aca ctc gtg gag gca cac tcg tgg agg       1056
Tyr Ser Arg Gly Asn Glu Lys Thr Leu Val Glu Ala His Ser Trp Arg           
            340                 345                 350                   

cgt cgg cag agc agg cag acc aag gag ttc atc ttc tca gag ctg ctg       1104
Arg Arg Gln Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu           
        355                 360                 365                       

tcc aac ctg cac tcg cgt ggg aac gag aag aca ctc atg gag gag tcg       1152
Ser Asn Leu His Ser Arg Gly Asn Glu Lys Thr Leu Met Glu Glu Ser           
    370                 375                 380                           

gcc gag cag gca cag cgg cgt gac gag act cgc gtg gga aga aga aga       1200
Ala Glu Gln Ala Gln Arg Arg Asp Glu Thr Arg Val Gly Arg Arg Arg           
385                 390                 395                 400           

cac tcc tgg agg agt cgg cag agc agg cag acc aag gag ttc atc ttc       1248
His Ser Trp Arg Ser Arg Gln Ser Arg Gln Thr Lys Glu Phe Ile Phe           
                405                 410                 415               

tcg gag ctg ctg tcc aac ctg tac tcg cgt cgg aac ctg cag aca ctt       1296
Ser Glu Leu Leu Ser Asn Leu Tyr Ser Arg Arg Asn Leu Gln Thr Leu           
            420                 425                 430                   

gtg gag gag tcg gca gag cag gca cag cgg tgc gac gag atg ctg ctt       1344
Val Glu Glu Ser Ala Glu Gln Ala Gln Arg Cys Asp Glu Met Leu Leu           
        435                 440                 445                       

ctc aga gct gct gtc caa cct gca ctg gcg tgg gaa cga gaa gac act       1392
Leu Arg Ala Ala Val Gln Pro Ala Leu Ala Trp Glu Arg Glu Asp Thr           
    450                 455                 460                           

cgt gga ggc gtc ggc aga gca ggc aga cca agg agt tca tct tct cag       1440
Arg Gly Gly Val Gly Arg Ala Gly Arg Pro Arg Ser Ser Ser Ser Gln           
465                 470                 475                 480           

agc tgc tgt cca acc tgc act cgc gtg gga acg aga aga cac tca tgg       1488
Ser Cys Cys Pro Thr Cys Thr Arg Val Gly Thr Arg Arg His Ser Trp           
                485                 490                 495               

agg agt cgg ccg agc agg cac agc ggc gtg acg aga ctc gcg tgg gaa       1536
Arg Ser Arg Pro Ser Arg His Ser Gly Val Thr Arg Leu Ala Trp Glu           
            500                 505                 510                   

gaa gaa gac act cct gga gga gtc ggc aga gca ggc aga cca agg agt       1584
Glu Glu Asp Thr Pro Gly Gly Val Gly Arg Ala Gly Arg Pro Arg Ser           
        515                 520                 525                       

tca tct tct cgg agc tgc tgt cca acc tgt act cgc gtc gga acc tgc       1632
Ser Ser Ser Arg Ser Cys Cys Pro Thr Cys Thr Arg Val Gly Thr Cys           
    530                 535                 540                           

aga cac ttg tgg agg agt cgg cag agc agg cac agc ggt gcg aca aga       1680
Arg His Leu Trp Arg Ser Arg Gln Ser Arg His Ser Gly Ala Thr Arg           
545                 550                 555                 560           

tgc tgc ttc tca gag ctg ctg tcc aac ctg cac tgg cgt ggg aac gag       1728
Cys Cys Phe Ser Glu Leu Leu Ser Asn Leu His Trp Arg Gly Asn Glu           
                565                 570                 575               

aag aca ctc gtg gag gcg tcg gca gag cag gca gac caa gga gtt cat       1776
Lys Thr Leu Val Glu Ala Ser Ala Glu Gln Ala Asp Gln Gly Val His           
            580                 585                 590                   

ctt ctc aga gct gcc gtc caa cct gtc ctc gcg tgg gaa cga gaa gac       1824
Leu Leu Arg Ala Ala Val Gln Pro Val Leu Ala Trp Glu Arg Glu Asp           
        595                 600                 605                       

act cgt gga ggc gtc ggc aga gca ggc aga cca agg agt tca tct tct       1872
Thr Arg Gly Gly Val Gly Arg Ala Gly Arg Pro Arg Ser Ser Ser Ser           
    610                 615                 620                           

cag agc tgc tgt cca acc tgc act cgc gtg gga acg aga aga cac tcg       1920
Gln Ser Cys Cys Pro Thr Cys Thr Arg Val Gly Thr Arg Arg His Ser           
625                 630                 635                 640           

tgg agg cgt cgg cag agc agg cag acc aag gag ttc atc ttc tca gag       1968
Trp Arg Arg Arg Gln Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser Glu           
                645                 650                 655               

ctg ctg tcc aaa ctg cac tcg cgt ggg aac gag aag aca ctc atg gag       2016
Leu Leu Ser Lys Leu His Ser Arg Gly Asn Glu Lys Thr Leu Met Glu           
            660                 665                 670                   

gag tcg gca gag cag gca cag cgg tgt gac gag act cgc gtg gga aga       2064
Glu Ser Ala Glu Gln Ala Gln Arg Cys Asp Glu Thr Arg Val Gly Arg           
        675                 680                 685                       

aga aga cac tcc tgg agg agt cgg cag agc agg cag acc aag gag ttc       2112
Arg Arg His Ser Trp Arg Ser Arg Gln Ser Arg Gln Thr Lys Glu Phe           
    690                 695                 700                           

atc ttc tcg gag ctg ctg tcc aac ctg tac tcg cgt cgg aac ctg cag       2160
Ile Phe Ser Glu Leu Leu Ser Asn Leu Tyr Ser Arg Arg Asn Leu Gln           
705                 710                 715                 720           

aca ctt gtg gag gag tcg gca gag cag gca cag cga aga cac tcg tgg       2208
Thr Leu Val Glu Glu Ser Ala Glu Gln Ala Gln Arg Arg His Ser Trp           
                725                 730                 735               

agg cgt cgg cag agc agg cag acc aag gag ttc atc ttc tca gag ctg       2256
Arg Arg Arg Gln Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser Glu Leu           
            740                 745                 750                   

ctg tcc aac ctg tac tcg cgt ggg aac gag aag aca ctc gtg gag gcg       2304
Leu Ser Asn Leu Tyr Ser Arg Gly Asn Glu Lys Thr Leu Val Glu Ala           
        755                 760                 765                       

tcg gca gag cag gca gac caa gga gtt cat ctt ctc aga cct gct gtc       2352
Ser Ala Glu Gln Ala Asp Gln Gly Val His Leu Leu Arg Pro Ala Val           
    770                 775                 780                           

caa cct gca ctc gcg tgg gaa cga gaa gac act cat gga gga gtc ggc       2400
Gln Pro Ala Leu Ala Trp Glu Arg Glu Asp Thr His Gly Gly Val Gly           
785                 790                 795                 800           

cga gca ggc aca gcg gcg tga                                           2421
Arg Ala Gly Thr Ala Ala                                                   
                805                                                       


<210>  618
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  618

Ser Gly Pro Arg Val Ser Pro Ala Pro Gly Ala Gly Glu Thr Arg Pro 
1               5                   10                  15      


Pro Pro Pro Pro Thr Gln Ala Ser Arg Ser Pro Gly Gly Gly Ala Gly 
            20                  25                  30          


Pro Ala Glu Gly Gly Arg Gly Gly Asp Pro Gly Pro Leu Pro Val Arg 
        35                  40                  45              


Leu Pro Leu Val Pro Arg Leu Pro His Leu Arg Pro Arg Pro Ala Leu 
    50                  55                  60                  


Arg Gly Arg Arg Arg Ala Pro His Arg Leu Leu Gln Trp Ser Val Ser 
65                  70                  75                  80  


Arg Gly Cys Gly Ser Trp Phe Leu Trp Lys Asp Ser Lys Ala Glu Glu 
                85                  90                  95      


Asn Gly Ser His Ser Phe Met His Ser Met Asp Pro Gln Leu Glu Arg 
            100                 105                 110         


Gln Met Glu Thr Thr Gln Asn Leu Val Asp Ser Tyr Met Ala Ile Val 
        115                 120                 125             


Asn Lys Thr Val Trp Asn Leu Met Val Gly Ala Lys Pro Lys Thr Ile 
    130                 135                 140                 


Met His Ile Met Ile Tyr Asn Val His Ala Pro Pro His Gly Asp Gln 
145                 150                 155                 160 


Gly Val His Leu Leu Arg Ala Ala Val Gln Pro Val Leu Ala Trp Glu 
                165                 170                 175     


Gln Gly Asp Thr Pro Gly Gly Val Gly Arg Ala Gly Thr Ala Ala Arg 
            180                 185                 190         


Arg Asp Ala Ala Ser Gln Ser Cys Cys Pro Thr Cys Thr Arg Val Gly 
        195                 200                 205             


Thr Arg Arg His Ser Trp Arg Arg Arg Gln Ser Arg His Gln Thr Ala 
    210                 215                 220                 


Leu Ala Trp Glu Arg Glu Asp Thr His Gly Gly Val Gly Arg Ala Gly 
225                 230                 235                 240 


Thr Ala Val Arg Arg Asp Ser Arg Gly Asn Glu Lys Thr Leu Val Glu 
                245                 250                 255     


Ala Ser Ala Glu Gln Ala Asp Gln Gly Val His Leu Leu Arg Ala Ala 
            260                 265                 270         


Val Gln Pro Ala Leu Ala Trp Glu Arg Glu Asp Thr Arg Gly Gly Val 
        275                 280                 285             


Gly Arg Ala Gly Arg Pro Arg Ser Ser Ser Ser Gln Ser Phe Cys Pro 
    290                 295                 300                 


Thr Cys Thr Arg Val Gly Thr Arg Arg His Ser Trp Arg Arg Arg Gln 
305                 310                 315                 320 


Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu Ser Asn Leu 
                325                 330                 335     


Tyr Ser Arg Gly Asn Glu Lys Thr Leu Val Glu Ala His Ser Trp Arg 
            340                 345                 350         


Arg Arg Gln Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu 
        355                 360                 365             


Ser Asn Leu His Ser Arg Gly Asn Glu Lys Thr Leu Met Glu Glu Ser 
    370                 375                 380                 


Ala Glu Gln Ala Gln Arg Arg Asp Glu Thr Arg Val Gly Arg Arg Arg 
385                 390                 395                 400 


His Ser Trp Arg Ser Arg Gln Ser Arg Gln Thr Lys Glu Phe Ile Phe 
                405                 410                 415     


Ser Glu Leu Leu Ser Asn Leu Tyr Ser Arg Arg Asn Leu Gln Thr Leu 
            420                 425                 430         


Val Glu Glu Ser Ala Glu Gln Ala Gln Arg Cys Asp Glu Met Leu Leu 
        435                 440                 445             


Leu Arg Ala Ala Val Gln Pro Ala Leu Ala Trp Glu Arg Glu Asp Thr 
    450                 455                 460                 


Arg Gly Gly Val Gly Arg Ala Gly Arg Pro Arg Ser Ser Ser Ser Gln 
465                 470                 475                 480 


Ser Cys Cys Pro Thr Cys Thr Arg Val Gly Thr Arg Arg His Ser Trp 
                485                 490                 495     


Arg Ser Arg Pro Ser Arg His Ser Gly Val Thr Arg Leu Ala Trp Glu 
            500                 505                 510         


Glu Glu Asp Thr Pro Gly Gly Val Gly Arg Ala Gly Arg Pro Arg Ser 
        515                 520                 525             


Ser Ser Ser Arg Ser Cys Cys Pro Thr Cys Thr Arg Val Gly Thr Cys 
    530                 535                 540                 


Arg His Leu Trp Arg Ser Arg Gln Ser Arg His Ser Gly Ala Thr Arg 
545                 550                 555                 560 


Cys Cys Phe Ser Glu Leu Leu Ser Asn Leu His Trp Arg Gly Asn Glu 
                565                 570                 575     


Lys Thr Leu Val Glu Ala Ser Ala Glu Gln Ala Asp Gln Gly Val His 
            580                 585                 590         


Leu Leu Arg Ala Ala Val Gln Pro Val Leu Ala Trp Glu Arg Glu Asp 
        595                 600                 605             


Thr Arg Gly Gly Val Gly Arg Ala Gly Arg Pro Arg Ser Ser Ser Ser 
    610                 615                 620                 


Gln Ser Cys Cys Pro Thr Cys Thr Arg Val Gly Thr Arg Arg His Ser 
625                 630                 635                 640 


Trp Arg Arg Arg Gln Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser Glu 
                645                 650                 655     


Leu Leu Ser Lys Leu His Ser Arg Gly Asn Glu Lys Thr Leu Met Glu 
            660                 665                 670         


Glu Ser Ala Glu Gln Ala Gln Arg Cys Asp Glu Thr Arg Val Gly Arg 
        675                 680                 685             


Arg Arg His Ser Trp Arg Ser Arg Gln Ser Arg Gln Thr Lys Glu Phe 
    690                 695                 700                 


Ile Phe Ser Glu Leu Leu Ser Asn Leu Tyr Ser Arg Arg Asn Leu Gln 
705                 710                 715                 720 


Thr Leu Val Glu Glu Ser Ala Glu Gln Ala Gln Arg Arg His Ser Trp 
                725                 730                 735     


Arg Arg Arg Gln Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser Glu Leu 
            740                 745                 750         


Leu Ser Asn Leu Tyr Ser Arg Gly Asn Glu Lys Thr Leu Val Glu Ala 
        755                 760                 765             


Ser Ala Glu Gln Ala Asp Gln Gly Val His Leu Leu Arg Pro Ala Val 
    770                 775                 780                 


Gln Pro Ala Leu Ala Trp Glu Arg Glu Asp Thr His Gly Gly Val Gly 
785                 790                 795                 800 


Arg Ala Gly Thr Ala Ala 
                805     


<210>  619
<211>  1484
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (230)..(1426)

<400>  619
cccgtgagga ggaaaaggtg tgtccgctgc cacccagtgt gagcgggtga caccacccgg       60

ttaggaaatc ccagctccca agagggtata aatccctgct ttactgctga gctcctgctg      120

gaggtgaaag tctggcctgg cagccttccc caggtgagca gcaacaaggc cacgtgctgc      180

tgggtctcag tcctccactt cccgtgtcct ctggaagttg tcaggagca atg ttg cgc      238
                                                      Met Leu Arg         
                                                      1                   

ttg tac gtg ttg gta atg gga gtt tct gcc ttc acc ctt cag cct gcg        286
Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu Gln Pro Ala           
    5                   10                  15                            

gca cac aca ggg gct gcc aga agc tgc cgg ttt cgt ggg agg cat tac        334
Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly Arg His Tyr           
20                  25                  30                  35            

aag cgg gag ttc agg ctg gaa ggg gag cct gta gcc ctg agg tgc ccc        382
Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu Arg Cys Pro           
                40                  45                  50                

cag gtg ccc tac tgg ttg tgg gcc tct gtc agc ccc cgc atc aac ctg        430
Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg Ile Asn Leu           
            55                  60                  65                    

aca tgg cat aaa aat gac tct gct agg acg gtc cca gga gaa gaa gag        478
Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly Glu Glu Glu           
        70                  75                  80                        

aca cgg atg tgg gcc cag gac ggt gct ctg tgg ctt ctg cca gcc ttg        526
Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu Pro Ala Leu           
    85                  90                  95                            

cag gag gac tct ggc acc tac gtc tgc act act aga aat gct tct tac        574
Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn Ala Ser Tyr           
100                 105                 110                 115           

tgt gac aaa atg tcc att gag ctc aga gtt ttt gag aat aca gat gct        622
Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn Thr Asp Ala           
                120                 125                 130               

ttc ctg ccg ttc atc tca tac ccg caa att tta acc ttg tca acc tct        670
Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu Ser Thr Ser           
            135                 140                 145                   

ggg gta tta gta tgc cct gac ctg agt gaa ttc acc cgt gac aaa act        718
Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg Asp Lys Thr           
        150                 155                 160                       

gac gtg aag att caa tgg tac aag gat tct ctt ctt ttg gat aaa gac        766
Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu Asp Lys Asp           
    165                 170                 175                           

aat gag aaa ttt cta agt gtg agg ggg acc act cac tta ctc gta cac        814
Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu Leu Val His           
180                 185                 190                 195           

gat gtg gcc ctg gaa gat gct ggc tat tac cgc tgt gtc ctg aca ttt        862
Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val Leu Thr Phe           
                200                 205                 210               

gcc cat gaa ggc cag caa tac aac atc act agg agt att gag cta cgc        910
Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile Glu Leu Arg           
            215                 220                 225                   

atc aag aaa aaa aaa gaa gag acc att cct gtg atc att tcc ccc ctc        958
Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile Ser Pro Leu           
        230                 235                 240                       

aag acc ata tca gct tct ctg ggg tca aga ctg aca atc ccg tgt aag       1006
Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile Pro Cys Lys           
    245                 250                 255                           

gtg ttt ctg gga acc ggc aca ccc tta acc acc atg ctg tgg tgg acg       1054
Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu Trp Trp Thr           
260                 265                 270                 275           

gcc aat gac acc cac ata gag agc gcc tac ccg gga ggc cgc gtg acc       1102
Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly Arg Val Thr           
                280                 285                 290               

gag ggg cca cgc cag gaa tat tca gaa aat aat gag aac tac att gaa       1150
Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn Tyr Ile Glu           
            295                 300                 305                   

gtg cca ttg att ttt gat cct gtc aca aga gag gat ttg cac atg gat       1198
Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu His Met Asp           
        310                 315                 320                       

ttt aaa tgt gtt gtc cat aat acc ctg agt ttt cag aca cta cgc acc       1246
Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr Leu Arg Thr           
    325                 330                 335                           

aca gtc aag gaa gcc tcc tcc acg ttc tcc tgg ggc att gtg ctg gcc       1294
Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile Val Leu Ala           
340                 345                 350                 355           

cca ctt tca ctg gcc ttc ttg gtt ttg ggg gga ata tgg atg cac aga       1342
Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp Met His Arg           
                360                 365                 370               

cgg tgc aaa cac aga act gga aaa gca gat ggt ctg act gtg cta tgg       1390
Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr Val Leu Trp           
            375                 380                 385                   

cct cat cat caa gac ttt caa tcc tat ccc aag tga aataaatgga            1436
Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys                               
        390                 395                                           

atgaaataat tcaaacacaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                  1484


<210>  620
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  620

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  621
<211>  3637
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (58)..(1314)

<400>  621
cgggagtagc gcagtcgcca aagccgccgc tgccaaagct gccgccacta gccgggc          57

atg gcc atg gcg tcc ccg gcc atc ggg cag cgc ccg tac ccg cta cta        105
Met Ala Met Ala Ser Pro Ala Ile Gly Gln Arg Pro Tyr Pro Leu Leu           
1               5                   10                  15                

ttg gac ccc gag ccg ccg cgc tat cta cag agc ctg agc ggc ccc gag        153
Leu Asp Pro Glu Pro Pro Arg Tyr Leu Gln Ser Leu Ser Gly Pro Glu           
            20                  25                  30                    

cta ccg ccg ccg ccc ccc gac cgg tcc tcg cgc ctc tgt gtc ccg gcg        201
Leu Pro Pro Pro Pro Pro Asp Arg Ser Ser Arg Leu Cys Val Pro Ala           
        35                  40                  45                        

ccc ctc tcc act gcg ccc ggg gcg cgc gag ggg cgc agc gcc cgg agg        249
Pro Leu Ser Thr Ala Pro Gly Ala Arg Glu Gly Arg Ser Ala Arg Arg           
    50                  55                  60                            

gct gcc cgg ggg aac ctg gag ccc ccg ccc cgg gcc tcc cga ccc gct        297
Ala Ala Arg Gly Asn Leu Glu Pro Pro Pro Arg Ala Ser Arg Pro Ala           
65                  70                  75                  80            

cgc ccg ctc cgg cct ggt ctg cag cag aga ctg cgg cgg cgg cct gga        345
Arg Pro Leu Arg Pro Gly Leu Gln Gln Arg Leu Arg Arg Arg Pro Gly           
                85                  90                  95                

gcg ccc cga ccc cgc gac gtg cgg agc atc ttc gag cag ccg cag gat        393
Ala Pro Arg Pro Arg Asp Val Arg Ser Ile Phe Glu Gln Pro Gln Asp           
            100                 105                 110                   

ccc aga gtc ccg gcg gag cga ggc gag ggg cac tgc ttc gcc gag ttg        441
Pro Arg Val Pro Ala Glu Arg Gly Glu Gly His Cys Phe Ala Glu Leu           
        115                 120                 125                       

gtg ctg ccg ggc ggc ccc ggc tgg tgt gac ctg tgc gga cga gag gtg        489
Val Leu Pro Gly Gly Pro Gly Trp Cys Asp Leu Cys Gly Arg Glu Val           
    130                 135                 140                           

ctg cgg cag gcg ctg cgc tgc act aac tgt aaa ttc acc tgt cac cca        537
Leu Arg Gln Ala Leu Arg Cys Thr Asn Cys Lys Phe Thr Cys His Pro           
145                 150                 155                 160           

gaa tgc cgc agc ctg atc cag ttg gac tgc agt cag cag gag ggt tta        585
Glu Cys Arg Ser Leu Ile Gln Leu Asp Cys Ser Gln Gln Glu Gly Leu           
                165                 170                 175               

tcc cgg gac aga ccc tct cca gaa agc acc ctc acc gtg acc ttc agc        633
Ser Arg Asp Arg Pro Ser Pro Glu Ser Thr Leu Thr Val Thr Phe Ser           
            180                 185                 190                   

cag aat gtc tgt aaa cct gtg gag gag aca cag cgc ccg ccc aca ctg        681
Gln Asn Val Cys Lys Pro Val Glu Glu Thr Gln Arg Pro Pro Thr Leu           
        195                 200                 205                       

cag gag atc aag cag aag atc gac agc tac aac acg cga gag aag aac        729
Gln Glu Ile Lys Gln Lys Ile Asp Ser Tyr Asn Thr Arg Glu Lys Asn           
    210                 215                 220                           

tgc ctg ggc atg aaa ctg agt gaa gac ggc acc tac acg ggt ttc atc        777
Cys Leu Gly Met Lys Leu Ser Glu Asp Gly Thr Tyr Thr Gly Phe Ile           
225                 230                 235                 240           

aaa gtg cat ctg aaa ctc cgg cgg cct gtg acg gtg cct gct ggg atc        825
Lys Val His Leu Lys Leu Arg Arg Pro Val Thr Val Pro Ala Gly Ile           
                245                 250                 255               

cgg ccc cag tcc atc tat gat gcc atc aag gag gtg aac ctg gcg gct        873
Arg Pro Gln Ser Ile Tyr Asp Ala Ile Lys Glu Val Asn Leu Ala Ala           
            260                 265                 270                   

acc acg gac aag cgg aca tcc ttc tac ctg ccc cta gat gcc atc aag        921
Thr Thr Asp Lys Arg Thr Ser Phe Tyr Leu Pro Leu Asp Ala Ile Lys           
        275                 280                 285                       

cag ctg cac atc agc agc acc acc acc gtc agt gag gtc atc cag ggg        969
Gln Leu His Ile Ser Ser Thr Thr Thr Val Ser Glu Val Ile Gln Gly           
    290                 295                 300                           

ctg ctc aag aag ttc atg gtt gtg gac aat ccc cag aag ttt gca ctt       1017
Leu Leu Lys Lys Phe Met Val Val Asp Asn Pro Gln Lys Phe Ala Leu           
305                 310                 315                 320           

ttt aag cgg ata cac aag gac gga caa gtg ctc ttc cag aaa ctc tcc       1065
Phe Lys Arg Ile His Lys Asp Gly Gln Val Leu Phe Gln Lys Leu Ser           
                325                 330                 335               

att gct gac cgc ccc ctc tac ctg cgc ctg ctt gct ggg cct gac acg       1113
Ile Ala Asp Arg Pro Leu Tyr Leu Arg Leu Leu Ala Gly Pro Asp Thr           
            340                 345                 350                   

gag gtc ctc agc ttt gtg cta aag gag aat gaa act gga gag gta gag       1161
Glu Val Leu Ser Phe Val Leu Lys Glu Asn Glu Thr Gly Glu Val Glu           
        355                 360                 365                       

tgg gat gcc ttc tcc atc cct gaa ctt cag aac ttc cta aca atc ctg       1209
Trp Asp Ala Phe Ser Ile Pro Glu Leu Gln Asn Phe Leu Thr Ile Leu           
    370                 375                 380                           

gaa aaa gag gag cag gac aaa atc caa caa gtg caa aag aag tat gac       1257
Glu Lys Glu Glu Gln Asp Lys Ile Gln Gln Val Gln Lys Lys Tyr Asp           
385                 390                 395                 400           

aag ttt agg cag aaa ctg gag gag gcc tta aga gaa tcc cag ggc aaa       1305
Lys Phe Arg Gln Lys Leu Glu Glu Ala Leu Arg Glu Ser Gln Gly Lys           
                405                 410                 415               

cct ggg taa ccggtcctgc ttcctctcct cctggtgcat tcagatttat               1354
Pro Gly                                                                   
                                                                          

ttgtattatt aattattatt ttgcaacaga cactttttct caggacatct ctggcaggtg     1414

catttgtgcc tgcccagcag ttccagctgt ggcaaaagtc tcttccatgg acaagtgttt     1474

gcatgggggt tcagctgtgc ccgcccccag gctgtgcccc accacagatt ctgccaagga     1534

tcagaactca tgtgaaacaa acagctgacg tcctctctcg atctgcaagc ctttcaccaa     1594

ccaaatagtt gcctctctcg tcaccaaact ggaacctcac accagccggc aaaggaagga     1654

agaaaggttt tagagctgtg tgttctttct ctggctttga ttcttctttg agttctctta     1714

cttgccacgt acaggaccat tatttatgag tgaaaagttg tagcacattc cttttgcagg     1774

tctgagctaa gcccctgaaa gcagggtaat gctcataaaa ggactgttcc cgcggcccca     1834

aggtgcctgt tgttcacact taagggaagt ttataaagct actggcccca gatgctcagg     1894

gtaaggagca ccaaagctga ggctggctca gagatctcca gagaagctgc agcctgccct     1954

ggccctggct ctggccctgg cccacattgc acatggaaac ccaaaggcat atatctgcgt     2014

atgtgtggta cttagtcaca tctttgtcaa caaactgttc gtttttaagt tacaaatttg     2074

aatttaatgt tgtcatcatc gtcatgtgtt tccccaaagg gaagccagtc attgaccatt     2134

taaaaagtct cctgctaagt atggaaatca gacagtaaga gaaagccaaa aagcaatgca     2194

gagaaaggtg tccaagctgt cttcagcctt ccccagctaa agagcagagg agggcctggg     2254

ctacttgggt tccccatcgg cctccagcac tgcctccctc ctcccactgc gactctggga     2314

tctccaggtg ctgcccaagg agttgccttg attacagaga ggggagcctc caattcggcc     2374

aacttggagt cctttctgtt ttgaagcatg ggccagaccc ggcactgcgc tcggagagcc     2434

ggtgggcctg gcctccccgt cgacctcagt gcctttttgt tttcagagag aaataggagt     2494

agggcgagtt tgcctgaagc tctgctgctg gcttctcctg ccaggaagtg aacaatggcg     2554

gcggtgtggg agacaaggcc aggagagccc gcgttcagta tgggttgagg gtcacagacc     2614

tccctcccat ctgggtgcct gagttttgac tccaatcagt gataccagac cacattgaca     2674

gggaggatca aattcctgac ttacatttgc actggcttct tgtttaggct gaatcctaaa     2734

ataaattagt caaaaaattc caacaagtag ccaggactgc agagacactc cagtgcagag     2794

ggagaaggac ttgtaatttt caaagcaggg ctggttttcc aacccagcct ctgagaaacc     2854

atttctttgc tatcctctgc cttcccaagt ccctcttggg tcggttcaag cccaagcttg     2914

ttcgtgtagc ttcagaagtt ccctctctga cccaggctga gtccatactg cccctgatcc     2974

cagaaggaat gctgacccct cgtcgtatga actgtgcata gtctccagag cttcaaaggc     3034

aacacaagct cgcaactcta agattttttt aaaccacaaa aaccctggtt agccatctca     3094

tgctcagcct tatcacttcc ctccctttag aaactctctc cctgctgtat attaaaggga     3154

gcaggtggag agtcattttc cttcgtcctg catgtctcta acattaatag aaggcatggc     3214

tcctgctgca accgctgtga atgctgctga gaacctccct ctatggggat ggctatttta     3274

tttttgagaa ggaaaaaaaa agtcatgtat atatacacat aaaggcatat agctatatat     3334

aaagagataa gggtgtttat gaaatgagaa aattattgga caattcagac tttactaaag     3394

cacagttaga cccaaggcct atgctgaggt ctaaacctct gaaaaaagta tagtatcgag     3454

tacccgttcc ctcccagagg tgggagtaac tgctggtagt gccttctttg gttgtgttgc     3514

tcagtgtgta agtgtttgtt tccaggatat tttcttttta aatgtctttc ttatatgggt     3574

tttaaaaaaa agtaataaaa gcctgttgca aaaatgactc atgttaaaaa aaaaaaaaaa     3634

aaa                                                                   3637


<210>  622
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  622

Met Ala Met Ala Ser Pro Ala Ile Gly Gln Arg Pro Tyr Pro Leu Leu 
1               5                   10                  15      


Leu Asp Pro Glu Pro Pro Arg Tyr Leu Gln Ser Leu Ser Gly Pro Glu 
            20                  25                  30          


Leu Pro Pro Pro Pro Pro Asp Arg Ser Ser Arg Leu Cys Val Pro Ala 
        35                  40                  45              


Pro Leu Ser Thr Ala Pro Gly Ala Arg Glu Gly Arg Ser Ala Arg Arg 
    50                  55                  60                  


Ala Ala Arg Gly Asn Leu Glu Pro Pro Pro Arg Ala Ser Arg Pro Ala 
65                  70                  75                  80  


Arg Pro Leu Arg Pro Gly Leu Gln Gln Arg Leu Arg Arg Arg Pro Gly 
                85                  90                  95      


Ala Pro Arg Pro Arg Asp Val Arg Ser Ile Phe Glu Gln Pro Gln Asp 
            100                 105                 110         


Pro Arg Val Pro Ala Glu Arg Gly Glu Gly His Cys Phe Ala Glu Leu 
        115                 120                 125             


Val Leu Pro Gly Gly Pro Gly Trp Cys Asp Leu Cys Gly Arg Glu Val 
    130                 135                 140                 


Leu Arg Gln Ala Leu Arg Cys Thr Asn Cys Lys Phe Thr Cys His Pro 
145                 150                 155                 160 


Glu Cys Arg Ser Leu Ile Gln Leu Asp Cys Ser Gln Gln Glu Gly Leu 
                165                 170                 175     


Ser Arg Asp Arg Pro Ser Pro Glu Ser Thr Leu Thr Val Thr Phe Ser 
            180                 185                 190         


Gln Asn Val Cys Lys Pro Val Glu Glu Thr Gln Arg Pro Pro Thr Leu 
        195                 200                 205             


Gln Glu Ile Lys Gln Lys Ile Asp Ser Tyr Asn Thr Arg Glu Lys Asn 
    210                 215                 220                 


Cys Leu Gly Met Lys Leu Ser Glu Asp Gly Thr Tyr Thr Gly Phe Ile 
225                 230                 235                 240 


Lys Val His Leu Lys Leu Arg Arg Pro Val Thr Val Pro Ala Gly Ile 
                245                 250                 255     


Arg Pro Gln Ser Ile Tyr Asp Ala Ile Lys Glu Val Asn Leu Ala Ala 
            260                 265                 270         


Thr Thr Asp Lys Arg Thr Ser Phe Tyr Leu Pro Leu Asp Ala Ile Lys 
        275                 280                 285             


Gln Leu His Ile Ser Ser Thr Thr Thr Val Ser Glu Val Ile Gln Gly 
    290                 295                 300                 


Leu Leu Lys Lys Phe Met Val Val Asp Asn Pro Gln Lys Phe Ala Leu 
305                 310                 315                 320 


Phe Lys Arg Ile His Lys Asp Gly Gln Val Leu Phe Gln Lys Leu Ser 
                325                 330                 335     


Ile Ala Asp Arg Pro Leu Tyr Leu Arg Leu Leu Ala Gly Pro Asp Thr 
            340                 345                 350         


Glu Val Leu Ser Phe Val Leu Lys Glu Asn Glu Thr Gly Glu Val Glu 
        355                 360                 365             


Trp Asp Ala Phe Ser Ile Pro Glu Leu Gln Asn Phe Leu Thr Ile Leu 
    370                 375                 380                 


Glu Lys Glu Glu Gln Asp Lys Ile Gln Gln Val Gln Lys Lys Tyr Asp 
385                 390                 395                 400 


Lys Phe Arg Gln Lys Leu Glu Glu Ala Leu Arg Glu Ser Gln Gly Lys 
                405                 410                 415     


Pro Gly 
        


<210>  623
<211>  645
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (149)..(499)

<400>  623
gcttggcgcg tctccgtttc tcttctgagg ggctgagagt cgcggagttt cctagttgga       60

ggctgtggcg gacgcgattt gcttcctcat atagggttcc ggaggcggcg aaaagtccag      120

cgggtctccg aagccggtag acggagcc atg aag aag acg tcg ggc ttc agg         172
                               Met Lys Lys Thr Ser Gly Phe Arg            
                               1               5                          

agg ggg aag ggc ggg ctg ccc tgg ggc tcg gtc agc agc ccc ggg aag        220
Arg Gly Lys Gly Gly Leu Pro Trp Gly Ser Val Ser Ser Pro Gly Lys           
    10                  15                  20                            

gtg ggc gcg ggc gcc ggg agt gag agt gcg gac cac gcc tcc tcc cag        268
Val Gly Ala Gly Ala Gly Ser Glu Ser Ala Asp His Ala Ser Ser Gln           
25                  30                  35                  40            

ccc agg cgc cac gac ccg gac aag ggg ttc gac agg ctc cgc aga gct        316
Pro Arg Arg His Asp Pro Asp Lys Gly Phe Asp Arg Leu Arg Arg Ala           
                45                  50                  55                

gcc ggc cga cac cgg aca gag acg atg cgg cgg atc ctt tct ctg ccg        364
Ala Gly Arg His Arg Thr Glu Thr Met Arg Arg Ile Leu Ser Leu Pro           
            60                  65                  70                    

aag agt ggc gtg gat gac aga gac gag aag aac agg ctg tcc aac gaa        412
Lys Ser Gly Val Asp Asp Arg Asp Glu Lys Asn Arg Leu Ser Asn Glu           
        75                  80                  85                        

cag agt tct ggt gac tca tgg ctt tca ata gat gat gaa ctc ttt gat        460
Gln Ser Ser Gly Asp Ser Trp Leu Ser Ile Asp Asp Glu Leu Phe Asp           
    90                  95                  100                           

tct ggt acc aag att ctc ttc agc aat atc atc act tga agcctaaggt         509
Ser Gly Thr Lys Ile Leu Phe Ser Asn Ile Ile Thr                           
105                 110                 115                               

tgaaatgaaa gagtgtgttt cgaaccaggc agtcggaatg aaagatgtac aagcatgcac      569

atcagctttt tcagctttgg attttaatag tttgaccttc agtaatgagc ttcatgaaag      629

atctgagaat ttgaaa                                                      645


<210>  624
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  624

Met Lys Lys Thr Ser Gly Phe Arg Arg Gly Lys Gly Gly Leu Pro Trp 
1               5                   10                  15      


Gly Ser Val Ser Ser Pro Gly Lys Val Gly Ala Gly Ala Gly Ser Glu 
            20                  25                  30          


Ser Ala Asp His Ala Ser Ser Gln Pro Arg Arg His Asp Pro Asp Lys 
        35                  40                  45              


Gly Phe Asp Arg Leu Arg Arg Ala Ala Gly Arg His Arg Thr Glu Thr 
    50                  55                  60                  


Met Arg Arg Ile Leu Ser Leu Pro Lys Ser Gly Val Asp Asp Arg Asp 
65                  70                  75                  80  


Glu Lys Asn Arg Leu Ser Asn Glu Gln Ser Ser Gly Asp Ser Trp Leu 
                85                  90                  95      


Ser Ile Asp Asp Glu Leu Phe Asp Ser Gly Thr Lys Ile Leu Phe Ser 
            100                 105                 110         


Asn Ile Ile Thr 
        115     


<210>  625
<211>  723
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (149)..(400)

<400>  625
ccggcctctg ggcggagatc tgctgccgcg ttctaccctt ccggcccgtg ttctatccgc       60

cgcctccacc ttccatccgg cgccggcttt cggcgcgacg gtcgccgcgt tccatcgtcg      120

cgcggccctt cgggcgcccg agcccgca atg tcg ggc ccc aac gga gac ctg         172
                               Met Ser Gly Pro Asn Gly Asp Leu            
                               1               5                          

ggg atg ccg gtg gag gcg gga gcg gaa ggc gag gag gac ggc ttc ggg        220
Gly Met Pro Val Glu Ala Gly Ala Glu Gly Glu Glu Asp Gly Phe Gly           
    10                  15                  20                            

gaa gca gaa tac gct gcc atc aac tcc atg ctg gac cag atc aac tcc        268
Glu Ala Glu Tyr Ala Ala Ile Asn Ser Met Leu Asp Gln Ile Asn Ser           
25                  30                  35                  40            

tgt ctg gac cac ctg gag gag aag aat gac cac ctc cac gcc cgc ctc        316
Cys Leu Asp His Leu Glu Glu Lys Asn Asp His Leu His Ala Arg Leu           
                45                  50                  55                

cag gag ctg ctg gag tcc aac cgg cag aca cgc ctg gag ttc cag cag        364
Gln Glu Leu Leu Glu Ser Asn Arg Gln Thr Arg Leu Glu Phe Gln Gln           
            60                  65                  70                    

cag ctc ggg gag gcc ccc agt gat gcc agc ccc tag gctccaagag             410
Gln Leu Gly Glu Ala Pro Ser Asp Ala Ser Pro                               
        75                  80                                            

cccccaaccg ggacccaacc ctgcctccct gggctaggct ctggcctggg cactcacccc      470

ctggcttaga caccttctca agggctggcc ttcagggacc cctggtgggt ctgcctgcct      530

gggccaccct tcctgcctgg gcctcccctt ggcctacctg ggccagcccc caccacctgg      590

catgccctcc tggggccaag agtgggcctg caacccaccc acttgcctgc ccacccaact      650

cctgggcgct ccccactctg cccaggcctt gagtgtccac attaaatggg tctcccacac      710

cgcaaaaaaa aaa                                                         723


<210>  626
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  626

Met Ser Gly Pro Asn Gly Asp Leu Gly Met Pro Val Glu Ala Gly Ala 
1               5                   10                  15      


Glu Gly Glu Glu Asp Gly Phe Gly Glu Ala Glu Tyr Ala Ala Ile Asn 
            20                  25                  30          


Ser Met Leu Asp Gln Ile Asn Ser Cys Leu Asp His Leu Glu Glu Lys 
        35                  40                  45              


Asn Asp His Leu His Ala Arg Leu Gln Glu Leu Leu Glu Ser Asn Arg 
    50                  55                  60                  


Gln Thr Arg Leu Glu Phe Gln Gln Gln Leu Gly Glu Ala Pro Ser Asp 
65                  70                  75                  80  


Ala Ser Pro 
            


<210>  627
<211>  1519
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (345)..(629)

<400>  627
acgcgggtta atgaaataaa ttgtctacta tatataggtt ttgtgtgaac atacaaatga       60

aatgtactgt ctcagaataa tgtggttggg gaaatatctg gagacaaata caatgcaatt      120

gcaacataac agttacacac cagactctta acaggaataa tgtagtgtga tacttgaaag      180

cctaaactct gaaatgagat tgcctgagct gagatctcaa ttcctctaac tatgtaaccc      240

tgggcgagtt acttcaaagt gcctccgttt tcttctctgc aaaataacca ttgatttgaa      300

atgtggagga ttttgaaacc taagctaaga aatgtgggtt tgat atg ctg aaa aat       356
                                                 Met Leu Lys Asn          
                                                 1                        

agg gag cta ctt aaa att ttt gaa caa gca agt cac atg atg aaa tta        404
Arg Glu Leu Leu Lys Ile Phe Glu Gln Ala Ser His Met Met Lys Leu           
5                   10                  15                  20            

att gag gaa cat tgt att tgt gat tgc ata tgg atg gag tgg gag gac        452
Ile Glu Glu His Cys Ile Cys Asp Cys Ile Trp Met Glu Trp Glu Asp           
                25                  30                  35                

cta gag gca aag aca tta gat agg aga cca cca gaa caa act aga cgt        500
Leu Glu Ala Lys Thr Leu Asp Arg Arg Pro Pro Glu Gln Thr Arg Arg           
            40                  45                  50                    

gaa agg tgc agc tgt gga aat gga aag aga tgg gca aaa cca aaa atc        548
Glu Arg Cys Ser Cys Gly Asn Gly Lys Arg Trp Ala Lys Pro Lys Ile           
        55                  60                  65                        

acc aca gag aaa aaa aat cat cca gat ttc atg ata gat tgg atg tat        596
Thr Thr Glu Lys Lys Asn His Pro Asp Phe Met Ile Asp Trp Met Tyr           
    70                  75                  80                            

ttt gaa aca cct ctc tcc ata caa atg aaa taa ttcagcaaaa ttctagaaaa      649
Phe Glu Thr Pro Leu Ser Ile Gln Met Lys                                   
85                  90                                                    

tgctggtgta ggagctcagt ggaaatctcc cgtaagtgct gtgagaaatt ataaattctg      709

gggactccag ctgatacagt gtgcattcac ttacagcttc ctttgcccct ttgtacacta      769

gagcacaaca ggaaatattg gcttatctct gtaggaagtg tctctatagg agttgcttac      829

tgaactgaat atctttgttt agaactaatt gacctttcta aaacagcatt tttaaagagc      889

ttactcaaat aaggcagact ttaaccatct gataagtcag agacaaatca gtcctcttct      949

aagcaaggtt gacagtcagt gcaagagaaa agaaagcaca gaaagaaagg caccatcaga     1009

caaaagaaca gtgtattagt aaaaaccaga taattaagaa aattttattt aatgtgaaca     1069

ttgaattcta acacaaatcc ttttcctgca ttatgatagt atctgtgtga accaaccttt     1129

tttcagccct ttttgttatg gaatgttaag aatgttagtt tacaaggtta taaagtagaa     1189

gagtctaatt agaaaccaga aaatatctca gtcttttggt ctgaatttgt tttcctttgg     1249

ttagattctt aaagtagaaa aaaaaaaaac tactacttat tttgtaaaca ttttgaggat     1309

tttgattcag atattttaaa ttattatgag agataaagaa taaccctgtc caaaaaagta     1369

agaaaatgaa taaaatttgt ttaaaagagg attctcttaa aatataacca aagggacaga     1429

ttttgacagc agtcttcatt gttgttccat atgagtgttt tctaaaccta acagatgtaa     1489

gcaataaata agtaaaaaaa aaaaaaaaaa                                      1519


<210>  628
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  628

Met Leu Lys Asn Arg Glu Leu Leu Lys Ile Phe Glu Gln Ala Ser His 
1               5                   10                  15      


Met Met Lys Leu Ile Glu Glu His Cys Ile Cys Asp Cys Ile Trp Met 
            20                  25                  30          


Glu Trp Glu Asp Leu Glu Ala Lys Thr Leu Asp Arg Arg Pro Pro Glu 
        35                  40                  45              


Gln Thr Arg Arg Glu Arg Cys Ser Cys Gly Asn Gly Lys Arg Trp Ala 
    50                  55                  60                  


Lys Pro Lys Ile Thr Thr Glu Lys Lys Asn His Pro Asp Phe Met Ile 
65                  70                  75                  80  


Asp Trp Met Tyr Phe Glu Thr Pro Leu Ser Ile Gln Met Lys 
                85                  90                  


<210>  629
<211>  2323
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (36)..(1658)

<400>  629
tcagcatctt atccccactt tctggcctcc ccacc atg agc cgc caa ttc acc          53
                                       Met Ser Arg Gln Phe Thr            
                                       1               5                  

tac aag tcg gga gct gct gcc aag ggg ggc ttc agc ggc tgc tcc gct        101
Tyr Lys Ser Gly Ala Ala Ala Lys Gly Gly Phe Ser Gly Cys Ser Ala           
            10                  15                  20                    

gtg ctc tca ggg ggc agc tca tcc tcc tac cga gca ggg ggc aaa ggg        149
Val Leu Ser Gly Gly Ser Ser Ser Ser Tyr Arg Ala Gly Gly Lys Gly           
        25                  30                  35                        

ctc agt gga ggc ttc agc agt cgg agc ctt tac agc ctg ggg ggt gcc        197
Leu Ser Gly Gly Phe Ser Ser Arg Ser Leu Tyr Ser Leu Gly Gly Ala           
    40                  45                  50                            

cgg agc atc tct ttc aat gtg gcc agt ggc agt ggg tgg gca gga ggc        245
Arg Ser Ile Ser Phe Asn Val Ala Ser Gly Ser Gly Trp Ala Gly Gly           
55                  60                  65                  70            

tat gga ttt ggc cgg ggc cgg gcc agt ggc ttt gct ggc agc atg ttt        293
Tyr Gly Phe Gly Arg Gly Arg Ala Ser Gly Phe Ala Gly Ser Met Phe           
                75                  80                  85                

ggc agt gtg gcc ttg ggg tcc gtg tgt ccg tcg ttg tgc ccg ccc ggg        341
Gly Ser Val Ala Leu Gly Ser Val Cys Pro Ser Leu Cys Pro Pro Gly           
            90                  95                  100                   

ggt atc cat cag gtc acc atc aac aag agc ctc ctg gca ccc ctg aac        389
Gly Ile His Gln Val Thr Ile Asn Lys Ser Leu Leu Ala Pro Leu Asn           
        105                 110                 115                       

gtg gag ctg gac cct gaa atc cag aaa gtg cgt gcc cag gag cgg gag        437
Val Glu Leu Asp Pro Glu Ile Gln Lys Val Arg Ala Gln Glu Arg Glu           
    120                 125                 130                           

cag atc aag gtg ctg aac aac aag ttc gcc tcc ttc att gac aag gtg        485
Gln Ile Lys Val Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val           
135                 140                 145                 150           

cgg ttc ctg gag cag cag aac cag gtg ctg gag acc aag tgg gag ctg        533
Arg Phe Leu Glu Gln Gln Asn Gln Val Leu Glu Thr Lys Trp Glu Leu           
                155                 160                 165               

cta cag cag ctg gac ctg aac aac tgc aag aat aac ctg gag ccc atc        581
Leu Gln Gln Leu Asp Leu Asn Asn Cys Lys Asn Asn Leu Glu Pro Ile           
            170                 175                 180                   

ctt gag ggc tac atc agc aac ctg cgg aag cag ctg gag acg ctg tct        629
Leu Glu Gly Tyr Ile Ser Asn Leu Arg Lys Gln Leu Glu Thr Leu Ser           
        185                 190                 195                       

ggg gac agg gtg agg ctg gac tcg gag ctg agg agc gtg cgc gaa gtg        677
Gly Asp Arg Val Arg Leu Asp Ser Glu Leu Arg Ser Val Arg Glu Val           
    200                 205                 210                           

gtg gag gac tac aag aag agg tat gaa gaa gaa ata aac aag cgc aca        725
Val Glu Asp Tyr Lys Lys Arg Tyr Glu Glu Glu Ile Asn Lys Arg Thr           
215                 220                 225                 230           

act gct gag aat gaa ttt gtg gtg ctt aag aag gac gtg gac gca gct        773
Thr Ala Glu Asn Glu Phe Val Val Leu Lys Lys Asp Val Asp Ala Ala           
                235                 240                 245               

tac acg agc aaa gtg gag ctg cag gcc aag gtg gat gcc ctg gat gga        821
Tyr Thr Ser Lys Val Glu Leu Gln Ala Lys Val Asp Ala Leu Asp Gly           
            250                 255                 260                   

gaa atc aag ttc ttc aag tgt ctg tac gag ggg gag act gct cag atc        869
Glu Ile Lys Phe Phe Lys Cys Leu Tyr Glu Gly Glu Thr Ala Gln Ile           
        265                 270                 275                       

cag tcc cac atc agc gac acg tcc atc atc ctg tcc atg gac aac aac        917
Gln Ser His Ile Ser Asp Thr Ser Ile Ile Leu Ser Met Asp Asn Asn           
    280                 285                 290                           

cgg aac ctg gac ctg gac agc atc att gct gag gtc cgt gcc cag tat        965
Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu Val Arg Ala Gln Tyr           
295                 300                 305                 310           

gag gag atc gcc cgg aag agc aag gcc gag gcc gag gcc ctg tac cag       1013
Glu Glu Ile Ala Arg Lys Ser Lys Ala Glu Ala Glu Ala Leu Tyr Gln           
                315                 320                 325               

acc aag ttc cag gag ctg cag cta gca gcc ggc cgg cat ggg gat gac       1061
Thr Lys Phe Gln Glu Leu Gln Leu Ala Ala Gly Arg His Gly Asp Asp           
            330                 335                 340                   

ctg aaa cac acc aaa aat gag atc tca gag ctg acc cgt ctc atc caa       1109
Leu Lys His Thr Lys Asn Glu Ile Ser Glu Leu Thr Arg Leu Ile Gln           
        345                 350                 355                       

aga ctg cgc tcg gag att gag agt gtg aag aag cag tgt gcc aac ctg       1157
Arg Leu Arg Ser Glu Ile Glu Ser Val Lys Lys Gln Cys Ala Asn Leu           
    360                 365                 370                           

gag acg gcc atc gct gac gcc gag cag cgg ggg gac tgt gcc ctc aag       1205
Glu Thr Ala Ile Ala Asp Ala Glu Gln Arg Gly Asp Cys Ala Leu Lys           
375                 380                 385                 390           

gat gcc agg gcc aag ctg gat gag ctg gag ggc gcc ctg cag cag gcc       1253
Asp Ala Arg Ala Lys Leu Asp Glu Leu Glu Gly Ala Leu Gln Gln Ala           
                395                 400                 405               

aag gag gag ctg gca cgg atg ctg cgc gag tac caa gag ctt ttg agc       1301
Lys Glu Glu Leu Ala Arg Met Leu Arg Glu Tyr Gln Glu Leu Leu Ser           
            410                 415                 420                   

gtg aag ctg tcc ctg gat att gag atc gcc acc tac cgc aag ctg ctg       1349
Val Lys Leu Ser Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu           
        425                 430                 435                       

gag ggc gag gag tgc agg atg tcc gga gaa tat acc aac tcc gtg agc       1397
Glu Gly Glu Glu Cys Arg Met Ser Gly Glu Tyr Thr Asn Ser Val Ser           
    440                 445                 450                           

att tcg gtc atc aac agc tcc atg gcc ggg atg gca ggc aca ggg gct       1445
Ile Ser Val Ile Asn Ser Ser Met Ala Gly Met Ala Gly Thr Gly Ala           
455                 460                 465                 470           

ggc ttt gga ttc agc aat gct ggc acc tac ggc tac tgg ccc agc tct       1493
Gly Phe Gly Phe Ser Asn Ala Gly Thr Tyr Gly Tyr Trp Pro Ser Ser           
                475                 480                 485               

gtc agc ggg ggc tac agc atg ctg cct ggg ggc tgt gtc act ggc agt       1541
Val Ser Gly Gly Tyr Ser Met Leu Pro Gly Gly Cys Val Thr Gly Ser           
            490                 495                 500                   

ggg aac tgt agc ccc cgt ggg gaa gcc agg acc agg ctg ggg agt gca       1589
Gly Asn Cys Ser Pro Arg Gly Glu Ala Arg Thr Arg Leu Gly Ser Ala           
        505                 510                 515                       

agt gaa ttc agg gac tcc cag gga aag acc tta gct cta agc tca ccc       1637
Ser Glu Phe Arg Asp Ser Gln Gly Lys Thr Leu Ala Leu Ser Ser Pro           
    520                 525                 530                           

acc aaa aaa acc atg aga taa aagtgcaaca cagcccattt cccagtagtc          1688
Thr Lys Lys Thr Met Arg                                                   
535                 540                                                   

tgccttgccc tggcagactg ctccggactc ttctaggaaa ttcctctgtc tcatttgtcc     1748

tcatctcctt cttgctttgc tttgctgtgg acctctcctc cttctccttg acctctctgc     1808

ctcagtcttt gttaatgttg aatcaggatt tgagagctgg agcccatctt tctgcctcca     1868

tccaaagagg ccttttaact cagcctcccc ttctggaaga agacttggcc ttttctctgc     1928

ctgcatgtcc ctgtgcagag gaaggctgtc tctcaagggt aaccccaatc tgcctgtgct     1988

gctctttcat accctgtctc agtaactatt tggccatgtg ctccctgggt acacaagttt     2048

tcagatctac tgatagacct gcaggaactc tctcatgtta gagcaatact ggctcaggca     2108

aaacacctgg tgggaagttg tatcttgtat agccactgca tattacatag ccaggagtac     2168

cccttgaggc taattctacc aaccaaggga tttgtgctct tcatctgtgg gtacttgtcc     2228

ttgtttaggc ctcacctccc tgctcctgtg tcttaccaat aaacttataa agcccaaaaa     2288

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                2323


<210>  630
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  630

Met Ser Arg Gln Phe Thr Tyr Lys Ser Gly Ala Ala Ala Lys Gly Gly 
1               5                   10                  15      


Phe Ser Gly Cys Ser Ala Val Leu Ser Gly Gly Ser Ser Ser Ser Tyr 
            20                  25                  30          


Arg Ala Gly Gly Lys Gly Leu Ser Gly Gly Phe Ser Ser Arg Ser Leu 
        35                  40                  45              


Tyr Ser Leu Gly Gly Ala Arg Ser Ile Ser Phe Asn Val Ala Ser Gly 
    50                  55                  60                  


Ser Gly Trp Ala Gly Gly Tyr Gly Phe Gly Arg Gly Arg Ala Ser Gly 
65                  70                  75                  80  


Phe Ala Gly Ser Met Phe Gly Ser Val Ala Leu Gly Ser Val Cys Pro 
                85                  90                  95      


Ser Leu Cys Pro Pro Gly Gly Ile His Gln Val Thr Ile Asn Lys Ser 
            100                 105                 110         


Leu Leu Ala Pro Leu Asn Val Glu Leu Asp Pro Glu Ile Gln Lys Val 
        115                 120                 125             


Arg Ala Gln Glu Arg Glu Gln Ile Lys Val Leu Asn Asn Lys Phe Ala 
    130                 135                 140                 


Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Gln Val Leu 
145                 150                 155                 160 


Glu Thr Lys Trp Glu Leu Leu Gln Gln Leu Asp Leu Asn Asn Cys Lys 
                165                 170                 175     


Asn Asn Leu Glu Pro Ile Leu Glu Gly Tyr Ile Ser Asn Leu Arg Lys 
            180                 185                 190         


Gln Leu Glu Thr Leu Ser Gly Asp Arg Val Arg Leu Asp Ser Glu Leu 
        195                 200                 205             


Arg Ser Val Arg Glu Val Val Glu Asp Tyr Lys Lys Arg Tyr Glu Glu 
    210                 215                 220                 


Glu Ile Asn Lys Arg Thr Thr Ala Glu Asn Glu Phe Val Val Leu Lys 
225                 230                 235                 240 


Lys Asp Val Asp Ala Ala Tyr Thr Ser Lys Val Glu Leu Gln Ala Lys 
                245                 250                 255     


Val Asp Ala Leu Asp Gly Glu Ile Lys Phe Phe Lys Cys Leu Tyr Glu 
            260                 265                 270         


Gly Glu Thr Ala Gln Ile Gln Ser His Ile Ser Asp Thr Ser Ile Ile 
        275                 280                 285             


Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala 
    290                 295                 300                 


Glu Val Arg Ala Gln Tyr Glu Glu Ile Ala Arg Lys Ser Lys Ala Glu 
305                 310                 315                 320 


Ala Glu Ala Leu Tyr Gln Thr Lys Phe Gln Glu Leu Gln Leu Ala Ala 
                325                 330                 335     


Gly Arg His Gly Asp Asp Leu Lys His Thr Lys Asn Glu Ile Ser Glu 
            340                 345                 350         


Leu Thr Arg Leu Ile Gln Arg Leu Arg Ser Glu Ile Glu Ser Val Lys 
        355                 360                 365             


Lys Gln Cys Ala Asn Leu Glu Thr Ala Ile Ala Asp Ala Glu Gln Arg 
    370                 375                 380                 


Gly Asp Cys Ala Leu Lys Asp Ala Arg Ala Lys Leu Asp Glu Leu Glu 
385                 390                 395                 400 


Gly Ala Leu Gln Gln Ala Lys Glu Glu Leu Ala Arg Met Leu Arg Glu 
                405                 410                 415     


Tyr Gln Glu Leu Leu Ser Val Lys Leu Ser Leu Asp Ile Glu Ile Ala 
            420                 425                 430         


Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Met Ser Gly Glu 
        435                 440                 445             


Tyr Thr Asn Ser Val Ser Ile Ser Val Ile Asn Ser Ser Met Ala Gly 
    450                 455                 460                 


Met Ala Gly Thr Gly Ala Gly Phe Gly Phe Ser Asn Ala Gly Thr Tyr 
465                 470                 475                 480 


Gly Tyr Trp Pro Ser Ser Val Ser Gly Gly Tyr Ser Met Leu Pro Gly 
                485                 490                 495     


Gly Cys Val Thr Gly Ser Gly Asn Cys Ser Pro Arg Gly Glu Ala Arg 
            500                 505                 510         


Thr Arg Leu Gly Ser Ala Ser Glu Phe Arg Asp Ser Gln Gly Lys Thr 
        515                 520                 525             


Leu Ala Leu Ser Ser Pro Thr Lys Lys Thr Met Arg 
    530                 535                 540 


<210>  631
<211>  1726
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (350)..(1486)

<400>  631
gtcaggttca tggttacgaa gctgctgacc ccaggatccc agcccgtggg agagaagggg       60

gtctctgaca gcccccaccc ctccccactg ccagatcctt attgggtctg agtttcaggg      120

gtggggcccc agctggaggt tataaaacag ctcaatcggg gagtacaacc ttcggtttct      180

cttcggggaa agctgctttc agcgcacacg ggaagatatc agaaacatcc taggatcagg      240

acaccccaga tcttctcaac tggaaccacg aaggctgttt cttccacaca gcactttgat      300

ctccatttaa gcaggcacct ctgtcctgcg ttccggagct gcgttcccg atg gtc ctc      358
                                                      Met Val Leu         
                                                      1                   

ctt tgg ctc acg ctg ctc ctg atc gcc ctg ccc tgt ctc ctg caa acg        406
Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu Leu Gln Thr           
    5                   10                  15                            

aag gaa gat cca aac cca cca atc acg aac cta agg atg aaa gca aag        454
Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met Lys Ala Lys           
20                  25                  30                  35            

gct cag cag ttg acc tgg gac ctt aac aga aat gtg acc gat atc gag        502
Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr Asp Ile Glu           
                40                  45                  50                

tgt gtt aaa gac gcc gac tat tct atg ccg gca gtg aac aat agc tat        550
Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn Asn Ser Tyr           
            55                  60                  65                    

tgc cag ttt gga gca att tcc tta tgt gaa gtg acc aac tac acc gtc        598
Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn Tyr Thr Val           
        70                  75                  80                        

cga gtg gcc aac cca cca ttc tcc acg tgg atc ctc ttc cct gag aac        646
Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe Pro Glu Asn           
    85                  90                  95                            

agt ggg aag cct tgg gca ggt gcg gag aat ctg acc tgc tgg att cat        694
Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys Trp Ile His           
100                 105                 110                 115           

gac gtg gat ttc ttg agc tgc agc tgg gcg gta ggc ccg ggg gcc ccc        742
Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro Gly Ala Pro           
                120                 125                 130               

gcg gac gtc cag tac gac ctg tac ttg aac gtt gcc aac agg cgt caa        790
Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn Arg Arg Gln           
            135                 140                 145                   

cag tac gag tgt ctt cac tac aaa acg gat gct cag gga aca cgt atc        838
Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly Thr Arg Ile           
        150                 155                 160                       

ggg tgt cgt ttc gat gac atc tct cga ctc tcc agc ggt tct caa agt        886
Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly Ser Gln Ser           
    165                 170                 175                           

tcc cac atc ctg gtg cgg ggc agg agc gca gcc ttc ggt atc ccc tgc        934
Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly Ile Pro Cys           
180                 185                 190                 195           

aca gat aag ttt gtc gtc ttt tca cag att gag ata tta act cca ccc        982
Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu Thr Pro Pro           
                200                 205                 210               

aac atg act gca aag tgt aat aag aca cat tcc ttt atg cac tgg aaa       1030
Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met His Trp Lys           
            215                 220                 225                   

atg aga agt cat ttc aat cgc aaa ttt cgc tat gag ctt cag ata caa       1078
Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu Gln Ile Gln           
        230                 235                 240                       

aag aga atg cag cct gta atc aca gaa cag gtc aga gac aga acc tcc       1126
Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp Arg Thr Ser           
    245                 250                 255                           

ttc cag cta ctc aat cct gga acg tac aca gta caa ata aga gcc cgg       1174
Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile Arg Ala Arg           
260                 265                 270                 275           

gaa aga gtg tat gaa ttc ttg agc gcc tgg agc acc ccc cag cgc ttc       1222
Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro Gln Arg Phe           
                280                 285                 290               

gag tgc gac cag gag gag ggc gca aac aca cgt gcc tgg cgg acg tcg       1270
Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp Arg Thr Ser           
            295                 300                 305                   

ctg ctg atc gcg ctg ggg acg ctg ctg gcc ctg gtc tgt gtc ttc gtg       1318
Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys Val Phe Val           
        310                 315                 320                       

atc tgc aga agg tat ctg gtg atg cag aga ctc ttt ccc cgc atc cct       1366
Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro Arg Ile Pro           
    325                 330                 335                           

cac atg aaa gac ccc atc ggt gac agc ttc caa aac gac aag ctg gtg       1414
His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp Lys Leu Val           
340                 345                 350                 355           

gtc tgg gag gcg ggc aaa gcc ggc ctg gag gag tgt ctg gtg act gaa       1462
Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu Val Thr Glu           
                360                 365                 370               

gta cag gtc gtg cag aaa act tga gactggggtt cagggcttgt gggggtctgc      1516
Val Gln Val Val Gln Lys Thr                                               
            375                                                           

ctcaatctcc ctggccgggc caggcgcctg cacagactgg ctgctggacc tgcgcacgca     1576

gcccaggaat ggacattcct aacgggtggt gggcatggga gatgcctgtg taatttcgtc     1636

cgaagctgcc aggaagaaga acagaacttt gtgtgtttat ttcatgataa agtgattttt     1696

ttttttttaa cccaaaaaaa aaaaaaaaaa                                      1726


<210>  632
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  632

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met 
            20                  25                  30          


Lys Ala Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr 
        35                  40                  45              


Asp Ile Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn 
    50                  55                  60                  


Asn Ser Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn 
65                  70                  75                  80  


Tyr Thr Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe 
                85                  90                  95      


Pro Glu Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys 
            100                 105                 110         


Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro 
        115                 120                 125             


Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn 
    130                 135                 140                 


Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly 
145                 150                 155                 160 


Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly 
                165                 170                 175     


Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly 
            180                 185                 190         


Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu 
        195                 200                 205             


Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met 
    210                 215                 220                 


His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu 
225                 230                 235                 240 


Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp 
                245                 250                 255     


Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile 
            260                 265                 270         


Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro 
        275                 280                 285             


Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp 
    290                 295                 300                 


Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys 
305                 310                 315                 320 


Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro 
                325                 330                 335     


Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp 
            340                 345                 350         


Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu 
        355                 360                 365             


Val Thr Glu Val Gln Val Val Gln Lys Thr 
    370                 375             


<210>  633
<211>  966
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(966)

<400>  633
atg gtc aat ttg act tca atg agt gga ttc ctt ctt atg ggg ttt tct         48
Met Val Asn Leu Thr Ser Met Ser Gly Phe Leu Leu Met Gly Phe Ser           
1               5                   10                  15                

gat gag cgt aag ctt cag att tta cat gca ttg gta ttt ctg gtg aca         96
Asp Glu Arg Lys Leu Gln Ile Leu His Ala Leu Val Phe Leu Val Thr           
            20                  25                  30                    

tac ctg ctg gcc ttg aca ggc aac ctc ctc att atc acc atc att acc        144
Tyr Leu Leu Ala Leu Thr Gly Asn Leu Leu Ile Ile Thr Ile Ile Thr           
        35                  40                  45                        

gtg gac cgt cgt ctc cat tcc ccc atg tat tac ttt tta aag cac ctc        192
Val Asp Arg Arg Leu His Ser Pro Met Tyr Tyr Phe Leu Lys His Leu           
    50                  55                  60                            

tct ctt ctg gac ctc tgc ttc atc tct gtc aca gtc ccc cag tcc att        240
Ser Leu Leu Asp Leu Cys Phe Ile Ser Val Thr Val Pro Gln Ser Ile           
65                  70                  75                  80            

gca aat tca ctt atg ggc aac ggt tac att tct ctt gtt cag tgc att        288
Ala Asn Ser Leu Met Gly Asn Gly Tyr Ile Ser Leu Val Gln Cys Ile           
                85                  90                  95                

ctt cag gtt ttc ttc ttc ata gct ctg gcc tca tca gaa gtg gcc att        336
Leu Gln Val Phe Phe Phe Ile Ala Leu Ala Ser Ser Glu Val Ala Ile           
            100                 105                 110                   

ctc aca gtg atg tct tat gac agg tac gca gca atc tgt caa cca ctt        384
Leu Thr Val Met Ser Tyr Asp Arg Tyr Ala Ala Ile Cys Gln Pro Leu           
        115                 120                 125                       

cat tat gag act att atg gat ccc cgt gcc tgt agg cat gca gtg ata        432
His Tyr Glu Thr Ile Met Asp Pro Arg Ala Cys Arg His Ala Val Ile           
    130                 135                 140                           

gct gtg tgg att gct ggg ggc ctc tct ggg ctc atg cat gct gcc att        480
Ala Val Trp Ile Ala Gly Gly Leu Ser Gly Leu Met His Ala Ala Ile           
145                 150                 155                 160           

aac ttc tcc ata cct ctc tgt ggg aag aga gtc att cac caa ttc ttc        528
Asn Phe Ser Ile Pro Leu Cys Gly Lys Arg Val Ile His Gln Phe Phe           
                165                 170                 175               

tgt gat gtt cct cag atg ctg aaa cta gcc tgt tct tat gaa ttc att        576
Cys Asp Val Pro Gln Met Leu Lys Leu Ala Cys Ser Tyr Glu Phe Ile           
            180                 185                 190                   

aat gag att gca ctg gct gca ttc aca acg tct gca gca ttt atc tgt        624
Asn Glu Ile Ala Leu Ala Ala Phe Thr Thr Ser Ala Ala Phe Ile Cys           
        195                 200                 205                       

ttg atc tcc att gtg ctc tcc tac att cgc atc ttc tct aca gtg ctg        672
Leu Ile Ser Ile Val Leu Ser Tyr Ile Arg Ile Phe Ser Thr Val Leu           
    210                 215                 220                           

aga atc cca tca gct gag ggc cgg acc aag gtc ttc tcc acc tgc cta        720
Arg Ile Pro Ser Ala Glu Gly Arg Thr Lys Val Phe Ser Thr Cys Leu           
225                 230                 235                 240           

cca cac cta ttt gta gcc acc ttc ttt ctt tca gct gca ggc ttt gag        768
Pro His Leu Phe Val Ala Thr Phe Phe Leu Ser Ala Ala Gly Phe Glu           
                245                 250                 255               

ttt ctc aga ctg cct tct gat tcc tca tcg act gtg gac ctt gta ttc        816
Phe Leu Arg Leu Pro Ser Asp Ser Ser Ser Thr Val Asp Leu Val Phe           
            260                 265                 270                   

tcc gta ttc tat act gtg ata cct cca aca ctc aat cca gtc att tat        864
Ser Val Phe Tyr Thr Val Ile Pro Pro Thr Leu Asn Pro Val Ile Tyr           
        275                 280                 285                       

agc tta cgg aat gat tcc atg aag gca gca ctg agg aag atg ctg tca        912
Ser Leu Arg Asn Asp Ser Met Lys Ala Ala Leu Arg Lys Met Leu Ser           
    290                 295                 300                           

aag gaa gag ctt cct cag aga aaa atg tgc tta aaa gcc atg ttt aaa        960
Lys Glu Glu Leu Pro Gln Arg Lys Met Cys Leu Lys Ala Met Phe Lys           
305                 310                 315                 320           

ctc tga                                                                966
Leu                                                                       
                                                                          


<210>  634
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  634

Met Val Asn Leu Thr Ser Met Ser Gly Phe Leu Leu Met Gly Phe Ser 
1               5                   10                  15      


Asp Glu Arg Lys Leu Gln Ile Leu His Ala Leu Val Phe Leu Val Thr 
            20                  25                  30          


Tyr Leu Leu Ala Leu Thr Gly Asn Leu Leu Ile Ile Thr Ile Ile Thr 
        35                  40                  45              


Val Asp Arg Arg Leu His Ser Pro Met Tyr Tyr Phe Leu Lys His Leu 
    50                  55                  60                  


Ser Leu Leu Asp Leu Cys Phe Ile Ser Val Thr Val Pro Gln Ser Ile 
65                  70                  75                  80  


Ala Asn Ser Leu Met Gly Asn Gly Tyr Ile Ser Leu Val Gln Cys Ile 
                85                  90                  95      


Leu Gln Val Phe Phe Phe Ile Ala Leu Ala Ser Ser Glu Val Ala Ile 
            100                 105                 110         


Leu Thr Val Met Ser Tyr Asp Arg Tyr Ala Ala Ile Cys Gln Pro Leu 
        115                 120                 125             


His Tyr Glu Thr Ile Met Asp Pro Arg Ala Cys Arg His Ala Val Ile 
    130                 135                 140                 


Ala Val Trp Ile Ala Gly Gly Leu Ser Gly Leu Met His Ala Ala Ile 
145                 150                 155                 160 


Asn Phe Ser Ile Pro Leu Cys Gly Lys Arg Val Ile His Gln Phe Phe 
                165                 170                 175     


Cys Asp Val Pro Gln Met Leu Lys Leu Ala Cys Ser Tyr Glu Phe Ile 
            180                 185                 190         


Asn Glu Ile Ala Leu Ala Ala Phe Thr Thr Ser Ala Ala Phe Ile Cys 
        195                 200                 205             


Leu Ile Ser Ile Val Leu Ser Tyr Ile Arg Ile Phe Ser Thr Val Leu 
    210                 215                 220                 


Arg Ile Pro Ser Ala Glu Gly Arg Thr Lys Val Phe Ser Thr Cys Leu 
225                 230                 235                 240 


Pro His Leu Phe Val Ala Thr Phe Phe Leu Ser Ala Ala Gly Phe Glu 
                245                 250                 255     


Phe Leu Arg Leu Pro Ser Asp Ser Ser Ser Thr Val Asp Leu Val Phe 
            260                 265                 270         


Ser Val Phe Tyr Thr Val Ile Pro Pro Thr Leu Asn Pro Val Ile Tyr 
        275                 280                 285             


Ser Leu Arg Asn Asp Ser Met Lys Ala Ala Leu Arg Lys Met Leu Ser 
    290                 295                 300                 


Lys Glu Glu Leu Pro Gln Arg Lys Met Cys Leu Lys Ala Met Phe Lys 
305                 310                 315                 320 


Leu 
    


<210>  635
<211>  1913
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (224)..(1396)

<400>  635
ccggagagcg agatcaaagg gactggaaac agactgggga ctggcggggg gagggggccg       60

gccagcctgt ggagtcctcc ctgagaagcg gagggcccgg cttccaccgt gactccagcg      120

gcctgcttgg ggttttaatt attattttga aatttctgaa tcgagctaga gcgagagagc      180

gagagatctc cgtagactgc gactcgctgg ctttcgctcc gag atg atg cag agt        235
                                                Met Met Gln Ser           
                                                1                         

gcg act gtc ccc gcg gaa ggg gct gtc aag ggg ctc ccg gag atg cta        283
Ala Thr Val Pro Ala Glu Gly Ala Val Lys Gly Leu Pro Glu Met Leu           
5                   10                  15                  20            

ggt gtg ccg atg caa cag att ccc cag tgc gct ggc tgc aac cag cac        331
Gly Val Pro Met Gln Gln Ile Pro Gln Cys Ala Gly Cys Asn Gln His           
                25                  30                  35                

atc ctg gac aag ttc atc ctg aag gtc ctg gac aga cac tgg cac agc        379
Ile Leu Asp Lys Phe Ile Leu Lys Val Leu Asp Arg His Trp His Ser           
            40                  45                  50                    

tcc tgc ctc aag tgt gca gac tgc cag atg cag ctg gcg gac agg tgc        427
Ser Cys Leu Lys Cys Ala Asp Cys Gln Met Gln Leu Ala Asp Arg Cys           
        55                  60                  65                        

ttc tcc agg gct ggg agc gtc tac tgc aag gag gac ttc ttc aag cgc        475
Phe Ser Arg Ala Gly Ser Val Tyr Cys Lys Glu Asp Phe Phe Lys Arg           
    70                  75                  80                            

ttc ggc aca aaa tgc acg gcc tgc cag cag ggt atc ccc cca acc cag        523
Phe Gly Thr Lys Cys Thr Ala Cys Gln Gln Gly Ile Pro Pro Thr Gln           
85                  90                  95                  100           

gtg gtc cgc aag gcc cag gac ttt gtc tac cac ctg cac tgc ttt gct        571
Val Val Arg Lys Ala Gln Asp Phe Val Tyr His Leu His Cys Phe Ala           
                105                 110                 115               

tgc atc atc tgc aac cgg cag ctg gcc acg ggg gac gaa ttc tac ctc        619
Cys Ile Ile Cys Asn Arg Gln Leu Ala Thr Gly Asp Glu Phe Tyr Leu           
            120                 125                 130                   

atg gag gac ggg cgg ctg gtg tgc aag gaa gac tac gag aca gcc aag        667
Met Glu Asp Gly Arg Leu Val Cys Lys Glu Asp Tyr Glu Thr Ala Lys           
        135                 140                 145                       

cag aac gat gac tca gag gct gga gct aag cgg ccc cgg acc acc atc        715
Gln Asn Asp Asp Ser Glu Ala Gly Ala Lys Arg Pro Arg Thr Thr Ile           
    150                 155                 160                           

aca gcc aag cag ctg gag aca tta aag aat gca tac aag aac tcc ccc        763
Thr Ala Lys Gln Leu Glu Thr Leu Lys Asn Ala Tyr Lys Asn Ser Pro           
165                 170                 175                 180           

aag cct gcc cgg cac gtg agg gag cag ctg tcc tca gag aca ggc ctg        811
Lys Pro Ala Arg His Val Arg Glu Gln Leu Ser Ser Glu Thr Gly Leu           
                185                 190                 195               

gac atg agg gtc gta cag gtt tgg ttt cag aac aga agg gcc aaa gag        859
Asp Met Arg Val Val Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Glu           
            200                 205                 210                   

aaa cgc ctg aag aag gat gca ggg cgg cac cgc tgg ggg cag ttc tat        907
Lys Arg Leu Lys Lys Asp Ala Gly Arg His Arg Trp Gly Gln Phe Tyr           
        215                 220                 225                       

aag agc gtc aag agg agc cgg ggc agc agc aag cag gag aag gag agc        955
Lys Ser Val Lys Arg Ser Arg Gly Ser Ser Lys Gln Glu Lys Glu Ser           
    230                 235                 240                           

tct gca gag gac tgt ggg gtt agt gac agt gag ctg agc ttc cga gag       1003
Ser Ala Glu Asp Cys Gly Val Ser Asp Ser Glu Leu Ser Phe Arg Glu           
245                 250                 255                 260           

gat caa att ctc tca gaa ctt ggc cac acc aat agg att tat ggc aac       1051
Asp Gln Ile Leu Ser Glu Leu Gly His Thr Asn Arg Ile Tyr Gly Asn           
                265                 270                 275               

gtg ggg gac gtt aca ggc gga cag tta atg aat ggg agc ttc tcc atg       1099
Val Gly Asp Val Thr Gly Gly Gln Leu Met Asn Gly Ser Phe Ser Met           
            280                 285                 290                   

gac ggg aca gga caa tcc tat cag gac ttg agg gat ggg agc ccc tat       1147
Asp Gly Thr Gly Gln Ser Tyr Gln Asp Leu Arg Asp Gly Ser Pro Tyr           
        295                 300                 305                       

gga atc ccc cag tct cca tcc tcc ata tcg tcc ctg cca tcc cac gct       1195
Gly Ile Pro Gln Ser Pro Ser Ser Ile Ser Ser Leu Pro Ser His Ala           
    310                 315                 320                           

cct ttg ctc aat ggg ctg gat tac acg gtg gac agt aat ttg ggc atc       1243
Pro Leu Leu Asn Gly Leu Asp Tyr Thr Val Asp Ser Asn Leu Gly Ile           
325                 330                 335                 340           

att gcg cat gca ggg cag gga gta agc cag acg ctg aga gcc atg gct       1291
Ile Ala His Ala Gly Gln Gly Val Ser Gln Thr Leu Arg Ala Met Ala           
                345                 350                 355               

ggg gga ccc acc tct gac atc tcc aca gga agc agt gta ggc tat ccc       1339
Gly Gly Pro Thr Ser Asp Ile Ser Thr Gly Ser Ser Val Gly Tyr Pro           
            360                 365                 370                   

gac ttt cca act agc cca ggc tct tgg ctc gat gaa atg gat cat cct       1387
Asp Phe Pro Thr Ser Pro Gly Ser Trp Leu Asp Glu Met Asp His Pro           
        375                 380                 385                       

cct ttt taa acttctctcc tccccaccct acctgccccc ctggcttgag               1436
Pro Phe                                                                   
    390                                                                   

agaatatctt caaggatcaa aagagacttg ccttttaagg atcgaaagta cgccaatgtg     1496

aatttccatt attttcaatg gaagtcctcc gctgattcct agaaggctgt gagaccacac     1556

tagggcattg tttccctggg gaagcagtgg gagagcagac tcatctcaga acacagcaca     1616

gggggtaatg gcctagagct ctagggacac tggcttgttg ggtctctccc ctgctgttct     1676

gcttaggggc ttggctgctc agtgctttgg tagcacaagg tgactgtgat aggccccctt     1736

ggcctttggg aactttgctc caactggtgt gtctcacaca atgcctccca aaacactgct     1796

ctcaccagaa ctgagactcc taaggtagag gcctcacagc ccttgagtaa aataaaagtg     1856

atttctggac catcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa        1913


<210>  636
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  636

Met Met Gln Ser Ala Thr Val Pro Ala Glu Gly Ala Val Lys Gly Leu 
1               5                   10                  15      


Pro Glu Met Leu Gly Val Pro Met Gln Gln Ile Pro Gln Cys Ala Gly 
            20                  25                  30          


Cys Asn Gln His Ile Leu Asp Lys Phe Ile Leu Lys Val Leu Asp Arg 
        35                  40                  45              


His Trp His Ser Ser Cys Leu Lys Cys Ala Asp Cys Gln Met Gln Leu 
    50                  55                  60                  


Ala Asp Arg Cys Phe Ser Arg Ala Gly Ser Val Tyr Cys Lys Glu Asp 
65                  70                  75                  80  


Phe Phe Lys Arg Phe Gly Thr Lys Cys Thr Ala Cys Gln Gln Gly Ile 
                85                  90                  95      


Pro Pro Thr Gln Val Val Arg Lys Ala Gln Asp Phe Val Tyr His Leu 
            100                 105                 110         


His Cys Phe Ala Cys Ile Ile Cys Asn Arg Gln Leu Ala Thr Gly Asp 
        115                 120                 125             


Glu Phe Tyr Leu Met Glu Asp Gly Arg Leu Val Cys Lys Glu Asp Tyr 
    130                 135                 140                 


Glu Thr Ala Lys Gln Asn Asp Asp Ser Glu Ala Gly Ala Lys Arg Pro 
145                 150                 155                 160 


Arg Thr Thr Ile Thr Ala Lys Gln Leu Glu Thr Leu Lys Asn Ala Tyr 
                165                 170                 175     


Lys Asn Ser Pro Lys Pro Ala Arg His Val Arg Glu Gln Leu Ser Ser 
            180                 185                 190         


Glu Thr Gly Leu Asp Met Arg Val Val Gln Val Trp Phe Gln Asn Arg 
        195                 200                 205             


Arg Ala Lys Glu Lys Arg Leu Lys Lys Asp Ala Gly Arg His Arg Trp 
    210                 215                 220                 


Gly Gln Phe Tyr Lys Ser Val Lys Arg Ser Arg Gly Ser Ser Lys Gln 
225                 230                 235                 240 


Glu Lys Glu Ser Ser Ala Glu Asp Cys Gly Val Ser Asp Ser Glu Leu 
                245                 250                 255     


Ser Phe Arg Glu Asp Gln Ile Leu Ser Glu Leu Gly His Thr Asn Arg 
            260                 265                 270         


Ile Tyr Gly Asn Val Gly Asp Val Thr Gly Gly Gln Leu Met Asn Gly 
        275                 280                 285             


Ser Phe Ser Met Asp Gly Thr Gly Gln Ser Tyr Gln Asp Leu Arg Asp 
    290                 295                 300                 


Gly Ser Pro Tyr Gly Ile Pro Gln Ser Pro Ser Ser Ile Ser Ser Leu 
305                 310                 315                 320 


Pro Ser His Ala Pro Leu Leu Asn Gly Leu Asp Tyr Thr Val Asp Ser 
                325                 330                 335     


Asn Leu Gly Ile Ile Ala His Ala Gly Gln Gly Val Ser Gln Thr Leu 
            340                 345                 350         


Arg Ala Met Ala Gly Gly Pro Thr Ser Asp Ile Ser Thr Gly Ser Ser 
        355                 360                 365             


Val Gly Tyr Pro Asp Phe Pro Thr Ser Pro Gly Ser Trp Leu Asp Glu 
    370                 375                 380                 


Met Asp His Pro Pro Phe 
385                 390 


<210>  637
<211>  4199
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (460)..(2985)

<400>  637
agaaaaggag gaaggagaac attgctgtag cttggatcta caacctaaga aagcaagagt       60

gatcaatctc agctctgtta aacatcttgt ttacttactg cattcagcag cttgcaaatg      120

gttaactata tgcaaaaaag tcagcatagc tgtgaagtat gccgtgaatt ttaattgagg      180

gaaaaaggga caattgcttc aggatgctct agtatgcact ctgcttgaaa tattttcaat      240

gaaatgctca gtattctatc tttgaccaga ggttttaact ttatgaagct atgggacttg      300

acaaaaagtg atatttgaga agaaagtacg cagtggttgg tgttttcttt tttttaataa      360

aggaattgaa ttactttgaa cacctcttcc agctgtgcat tacagataac gtcaggaaga      420

gtctctgctt tacagaatcg gatttcatca catgacaac atg aag ctg tgg att         474
                                           Met Lys Leu Trp Ile            
                                           1               5              

cat ctc ttt tat tca tct ctc ctt gcc tgt ata tct tta cac tcc caa        522
His Leu Phe Tyr Ser Ser Leu Leu Ala Cys Ile Ser Leu His Ser Gln           
                10                  15                  20                

act cca gtg ctc tca tcc aga ggc tct tgt gat tct ctt tgc aat tgt        570
Thr Pro Val Leu Ser Ser Arg Gly Ser Cys Asp Ser Leu Cys Asn Cys           
            25                  30                  35                    

gag gaa aaa gat ggc aca atg cta ata aat tgt gaa gca aaa ggt atc        618
Glu Glu Lys Asp Gly Thr Met Leu Ile Asn Cys Glu Ala Lys Gly Ile           
        40                  45                  50                        

aag atg gta tct gaa ata agt gtg cca cca tca cga cct ttc caa cta        666
Lys Met Val Ser Glu Ile Ser Val Pro Pro Ser Arg Pro Phe Gln Leu           
    55                  60                  65                            

agc tta tta aat aac ggc ttg acg atg ctt cac aca aat gac ttt tct        714
Ser Leu Leu Asn Asn Gly Leu Thr Met Leu His Thr Asn Asp Phe Ser           
70                  75                  80                  85            

ggg ctt acc aat gct att tca ata cac ctt gga ttt aac aat att gca        762
Gly Leu Thr Asn Ala Ile Ser Ile His Leu Gly Phe Asn Asn Ile Ala           
                90                  95                  100               

gat att gag ata ggt gca ttt aat ggc ctt ggc ctc ctg aaa caa ctt        810
Asp Ile Glu Ile Gly Ala Phe Asn Gly Leu Gly Leu Leu Lys Gln Leu           
            105                 110                 115                   

cat atc aat cac aat tct tta gaa att ctt aaa gag gat act ttc cat        858
His Ile Asn His Asn Ser Leu Glu Ile Leu Lys Glu Asp Thr Phe His           
        120                 125                 130                       

gga ctg gaa aac ctg gaa ttc ctg caa gca gat aac aat ttt atc aca        906
Gly Leu Glu Asn Leu Glu Phe Leu Gln Ala Asp Asn Asn Phe Ile Thr           
    135                 140                 145                           

gtg att gaa cca agt gcc ttt agc aag ctc aac aga ctc aaa gtg tta        954
Val Ile Glu Pro Ser Ala Phe Ser Lys Leu Asn Arg Leu Lys Val Leu           
150                 155                 160                 165           

att tta aat gac aat gct att gag agt ctt cct cca aac atc ttc cga       1002
Ile Leu Asn Asp Asn Ala Ile Glu Ser Leu Pro Pro Asn Ile Phe Arg           
                170                 175                 180               

ttt gtt cct tta acc cat cta gat ctt cgt gga aat caa tta caa aca       1050
Phe Val Pro Leu Thr His Leu Asp Leu Arg Gly Asn Gln Leu Gln Thr           
            185                 190                 195                   

ttg cct tat gtt ggt ttt ctc gaa cac att ggc cga ata ttg gat ctt       1098
Leu Pro Tyr Val Gly Phe Leu Glu His Ile Gly Arg Ile Leu Asp Leu           
        200                 205                 210                       

cag ttg gag gac aac aaa tgg gcc tgc aat tgt gac tta ttg cag tta       1146
Gln Leu Glu Asp Asn Lys Trp Ala Cys Asn Cys Asp Leu Leu Gln Leu           
    215                 220                 225                           

aaa act tgg ttg gag aac atg cct cca cag tct ata att ggt gat gtt       1194
Lys Thr Trp Leu Glu Asn Met Pro Pro Gln Ser Ile Ile Gly Asp Val           
230                 235                 240                 245           

gtc tgc aac agc cct cca ttt ttt aaa gga agt ata ctc agt aga cta       1242
Val Cys Asn Ser Pro Pro Phe Phe Lys Gly Ser Ile Leu Ser Arg Leu           
                250                 255                 260               

aag aag gaa tct att tgc cct act cca cca gtg tat gaa gaa cat gag       1290
Lys Lys Glu Ser Ile Cys Pro Thr Pro Pro Val Tyr Glu Glu His Glu           
            265                 270                 275                   

gat cct tca gga tca tta cat ctg gca gca aca tct tca ata aat gat       1338
Asp Pro Ser Gly Ser Leu His Leu Ala Ala Thr Ser Ser Ile Asn Asp           
        280                 285                 290                       

agt cgc atg tca act aag acc acg tcc att cta aaa cta ccc acc aaa       1386
Ser Arg Met Ser Thr Lys Thr Thr Ser Ile Leu Lys Leu Pro Thr Lys           
    295                 300                 305                           

gca cca ggt ttg ata cct tat att aca aag cca tcc act caa ctt cca       1434
Ala Pro Gly Leu Ile Pro Tyr Ile Thr Lys Pro Ser Thr Gln Leu Pro           
310                 315                 320                 325           

gga cct tac tgc cct att cct tgt aac tgc aaa gtc cta tcc cca tca       1482
Gly Pro Tyr Cys Pro Ile Pro Cys Asn Cys Lys Val Leu Ser Pro Ser           
                330                 335                 340               

gga ctt cta ata cat tgt cag gag cgc aac att gaa agc tta tca gat       1530
Gly Leu Leu Ile His Cys Gln Glu Arg Asn Ile Glu Ser Leu Ser Asp           
            345                 350                 355                   

ctg aga cct cct ccg caa aat cct aga aag ctc att cta gcg gga aat       1578
Leu Arg Pro Pro Pro Gln Asn Pro Arg Lys Leu Ile Leu Ala Gly Asn           
        360                 365                 370                       

att att cac agt tta atg aag tct gat cta gtg gaa tat ttc act ttg       1626
Ile Ile His Ser Leu Met Lys Ser Asp Leu Val Glu Tyr Phe Thr Leu           
    375                 380                 385                           

gaa atg ctt cac ttg gga aac aat cgt att gaa gtt ctt gaa gaa gga       1674
Glu Met Leu His Leu Gly Asn Asn Arg Ile Glu Val Leu Glu Glu Gly           
390                 395                 400                 405           

tcg ttt atg aac cta acg aga tta caa aaa ctc tat cta aat ggt aac       1722
Ser Phe Met Asn Leu Thr Arg Leu Gln Lys Leu Tyr Leu Asn Gly Asn           
                410                 415                 420               

cac ctg acc aaa tta agt aaa ggc atg ttc ctt ggt ctc cat aat ctt       1770
His Leu Thr Lys Leu Ser Lys Gly Met Phe Leu Gly Leu His Asn Leu           
            425                 430                 435                   

gaa tac tta tat ctt gaa tac aat gcc att aag gaa ata ctg cca gga       1818
Glu Tyr Leu Tyr Leu Glu Tyr Asn Ala Ile Lys Glu Ile Leu Pro Gly           
        440                 445                 450                       

acc ttt aat cca atg cct aaa ctt aaa gtc ctg tat tta aat aac aac       1866
Thr Phe Asn Pro Met Pro Lys Leu Lys Val Leu Tyr Leu Asn Asn Asn           
    455                 460                 465                           

ctc ctc caa gtt tta cca cca cat att ttt tca ggg gtt cct cta act       1914
Leu Leu Gln Val Leu Pro Pro His Ile Phe Ser Gly Val Pro Leu Thr           
470                 475                 480                 485           

aag gta aat ctt aaa aca aac cag ttt acc cat cta cct gta agt aat       1962
Lys Val Asn Leu Lys Thr Asn Gln Phe Thr His Leu Pro Val Ser Asn           
                490                 495                 500               

att ttg gat gat ctt gat ttg cta acc cag att gac ctt gag gat aac       2010
Ile Leu Asp Asp Leu Asp Leu Leu Thr Gln Ile Asp Leu Glu Asp Asn           
            505                 510                 515                   

ccc tgg gac tgc tcc tgt gac ctg gtt gga ctg cag caa tgg ata caa       2058
Pro Trp Asp Cys Ser Cys Asp Leu Val Gly Leu Gln Gln Trp Ile Gln           
        520                 525                 530                       

aag tta agc aag aac aca gtg aca gat gac atc ctc tgc act tcc ccc       2106
Lys Leu Ser Lys Asn Thr Val Thr Asp Asp Ile Leu Cys Thr Ser Pro           
    535                 540                 545                           

ggg cat ctc gac aaa aag gaa ttg aaa gcc cta aat agt gaa att ctc       2154
Gly His Leu Asp Lys Lys Glu Leu Lys Ala Leu Asn Ser Glu Ile Leu           
550                 555                 560                 565           

tgt cca ggt tta gta aat aac cca tcc atg cca aca cag act agt tac       2202
Cys Pro Gly Leu Val Asn Asn Pro Ser Met Pro Thr Gln Thr Ser Tyr           
                570                 575                 580               

ctt atg gtc acc act cct gca aca aca aca aat acg gct gat act att       2250
Leu Met Val Thr Thr Pro Ala Thr Thr Thr Asn Thr Ala Asp Thr Ile           
            585                 590                 595                   

tta cga tct ctt acg gac gct gtg cca ctg tct gtt cta ata ttg gga       2298
Leu Arg Ser Leu Thr Asp Ala Val Pro Leu Ser Val Leu Ile Leu Gly           
        600                 605                 610                       

ctt ctg att atg ttc atc act att gtt ttc tgt gct gca ggg ata gtg       2346
Leu Leu Ile Met Phe Ile Thr Ile Val Phe Cys Ala Ala Gly Ile Val           
    615                 620                 625                           

gtt ctt gtt ctt cac cgc agg aga aga tac aaa aag aaa caa gta gat       2394
Val Leu Val Leu His Arg Arg Arg Arg Tyr Lys Lys Lys Gln Val Asp           
630                 635                 640                 645           

gag caa atg aga gac aac agt cct gtg cat ctt cag tac agc atg tat       2442
Glu Gln Met Arg Asp Asn Ser Pro Val His Leu Gln Tyr Ser Met Tyr           
                650                 655                 660               

ggc cat aaa acc act cat cac act act gaa aga ccc tct gcc tca ctc       2490
Gly His Lys Thr Thr His His Thr Thr Glu Arg Pro Ser Ala Ser Leu           
            665                 670                 675                   

tat gaa cag cac atg gtg agc ccc atg gtt cat gtc tat aga agt cca       2538
Tyr Glu Gln His Met Val Ser Pro Met Val His Val Tyr Arg Ser Pro           
        680                 685                 690                       

tcc ttt ggt cca aag cat ctg gaa gag gaa gaa gag agg aat gag aaa       2586
Ser Phe Gly Pro Lys His Leu Glu Glu Glu Glu Glu Arg Asn Glu Lys           
    695                 700                 705                           

gaa gga agt gat gca aaa cat ctc caa aga agt ctt ttg gaa cag gaa       2634
Glu Gly Ser Asp Ala Lys His Leu Gln Arg Ser Leu Leu Glu Gln Glu           
710                 715                 720                 725           

aat cat tca cca ctc aca ggg tca aat atg aaa tac aaa acc acg aac       2682
Asn His Ser Pro Leu Thr Gly Ser Asn Met Lys Tyr Lys Thr Thr Asn           
                730                 735                 740               

caa tca aca gaa ttt tta tcc ttc caa gat gcc agc tca ttg tac aga       2730
Gln Ser Thr Glu Phe Leu Ser Phe Gln Asp Ala Ser Ser Leu Tyr Arg           
            745                 750                 755                   

aac att tta gaa aaa gaa agg gaa ctt cag caa ctg gga atc aca gaa       2778
Asn Ile Leu Glu Lys Glu Arg Glu Leu Gln Gln Leu Gly Ile Thr Glu           
        760                 765                 770                       

tac cta agg aaa aac att gct cag ctc cag cct gat atg gag gca cat       2826
Tyr Leu Arg Lys Asn Ile Ala Gln Leu Gln Pro Asp Met Glu Ala His           
    775                 780                 785                           

tat cct gga gcc cac gaa gag ctg aag tta atg gaa aca tta atg tac       2874
Tyr Pro Gly Ala His Glu Glu Leu Lys Leu Met Glu Thr Leu Met Tyr           
790                 795                 800                 805           

tca cgt cca agg aag gta tta gtg gaa cag aca aaa aat gag tat ttt       2922
Ser Arg Pro Arg Lys Val Leu Val Glu Gln Thr Lys Asn Glu Tyr Phe           
                810                 815                 820               

gaa ctt aaa gct aat tta cat gct gaa cct gac tat tta gaa gtc ctg       2970
Glu Leu Lys Ala Asn Leu His Ala Glu Pro Asp Tyr Leu Glu Val Leu           
            825                 830                 835                   

gag cag caa aca tag atggagagtt tgagggcttt cgcagaaatg ctgtgattct       3025
Glu Gln Gln Thr                                                           
        840                                                               

gttttaagtc cataccttgt aaataagtgc cttacgtgag tgtgtcatca atcagaacct     3085

aagcacagca gtaaactatg gggaaaaaaa aagaagaaga aaaagaaact cagggatcac     3145

tgggagaagc catggcatta tcttcaggca atttagtctg tcccaaataa aataaatcct     3205

tgcatgtaaa tcattcaagg attatagtaa tatttcatat actgaaaagt gtctcatagg     3265

agtcctcttg cacatctaaa aaggctgaac atttaagtat cccgaatttt cttgaattgc     3325

tttccctata gattaattac aattggattt catcatttaa aaaccatact tgtatatgta     3385

gttataatat gtaaggaata cattgtttat aaccagtatg tacttcaaaa atgtgtattg     3445

tcaaacatac ctaactttct tgcaataaat gcaaaagaaa ctggaacttg acaattataa     3505

atagtaatag tgaagaaaaa atagaaaggt tgcaattata taggccatgg gtggctcaaa     3565

actttgaaca tttgagctta aacaaatgcc actctcatgc attctaaatt aaaaagttaa     3625

aatgattaat agttcaggtg gaagaaataa gcatactttt tgggttttct acacattttg     3685

tgtagacaat tttaatgtca gtgctgctgt gaactaaagt atgtcattta tgctcaaagt     3745

ttaattcttc ttcttgggat attttaaaaa tgctactgag attctgctgt aaatatgact     3805

agagaatata ttgggtttgc tttatttcat aggcttaatt ctttgtaaat ctgaatgacc     3865

ataatagaaa tacatttctt gtggcaagta attcacagtt gtaaagtaaa taggaaaaat     3925

tattttattt ttattgatgt acattgatag atgccataaa tcagtagcaa aaggcacttc     3985

taaaggtaag tggtttaagt tgcctcaaga gagggacaat gtagctttat tttacaagaa     4045

ggcatagtta gatttctatg aaatatttat tctgtacagt tttatatagt tttggttcac     4105

aaaagtaatt attcttgggt gcctttcaag aaaattaaaa atactactca ctacaataaa     4165

actaaaatga aaactcaaaa aaaaaaaaaa aaaa                                 4199


<210>  638
<211>  841
<212>  PRT
<213>  Homo sapiens

<400>  638

Met Lys Leu Trp Ile His Leu Phe Tyr Ser Ser Leu Leu Ala Cys Ile 
1               5                   10                  15      


Ser Leu His Ser Gln Thr Pro Val Leu Ser Ser Arg Gly Ser Cys Asp 
            20                  25                  30          


Ser Leu Cys Asn Cys Glu Glu Lys Asp Gly Thr Met Leu Ile Asn Cys 
        35                  40                  45              


Glu Ala Lys Gly Ile Lys Met Val Ser Glu Ile Ser Val Pro Pro Ser 
    50                  55                  60                  


Arg Pro Phe Gln Leu Ser Leu Leu Asn Asn Gly Leu Thr Met Leu His 
65                  70                  75                  80  


Thr Asn Asp Phe Ser Gly Leu Thr Asn Ala Ile Ser Ile His Leu Gly 
                85                  90                  95      


Phe Asn Asn Ile Ala Asp Ile Glu Ile Gly Ala Phe Asn Gly Leu Gly 
            100                 105                 110         


Leu Leu Lys Gln Leu His Ile Asn His Asn Ser Leu Glu Ile Leu Lys 
        115                 120                 125             


Glu Asp Thr Phe His Gly Leu Glu Asn Leu Glu Phe Leu Gln Ala Asp 
    130                 135                 140                 


Asn Asn Phe Ile Thr Val Ile Glu Pro Ser Ala Phe Ser Lys Leu Asn 
145                 150                 155                 160 


Arg Leu Lys Val Leu Ile Leu Asn Asp Asn Ala Ile Glu Ser Leu Pro 
                165                 170                 175     


Pro Asn Ile Phe Arg Phe Val Pro Leu Thr His Leu Asp Leu Arg Gly 
            180                 185                 190         


Asn Gln Leu Gln Thr Leu Pro Tyr Val Gly Phe Leu Glu His Ile Gly 
        195                 200                 205             


Arg Ile Leu Asp Leu Gln Leu Glu Asp Asn Lys Trp Ala Cys Asn Cys 
    210                 215                 220                 


Asp Leu Leu Gln Leu Lys Thr Trp Leu Glu Asn Met Pro Pro Gln Ser 
225                 230                 235                 240 


Ile Ile Gly Asp Val Val Cys Asn Ser Pro Pro Phe Phe Lys Gly Ser 
                245                 250                 255     


Ile Leu Ser Arg Leu Lys Lys Glu Ser Ile Cys Pro Thr Pro Pro Val 
            260                 265                 270         


Tyr Glu Glu His Glu Asp Pro Ser Gly Ser Leu His Leu Ala Ala Thr 
        275                 280                 285             


Ser Ser Ile Asn Asp Ser Arg Met Ser Thr Lys Thr Thr Ser Ile Leu 
    290                 295                 300                 


Lys Leu Pro Thr Lys Ala Pro Gly Leu Ile Pro Tyr Ile Thr Lys Pro 
305                 310                 315                 320 


Ser Thr Gln Leu Pro Gly Pro Tyr Cys Pro Ile Pro Cys Asn Cys Lys 
                325                 330                 335     


Val Leu Ser Pro Ser Gly Leu Leu Ile His Cys Gln Glu Arg Asn Ile 
            340                 345                 350         


Glu Ser Leu Ser Asp Leu Arg Pro Pro Pro Gln Asn Pro Arg Lys Leu 
        355                 360                 365             


Ile Leu Ala Gly Asn Ile Ile His Ser Leu Met Lys Ser Asp Leu Val 
    370                 375                 380                 


Glu Tyr Phe Thr Leu Glu Met Leu His Leu Gly Asn Asn Arg Ile Glu 
385                 390                 395                 400 


Val Leu Glu Glu Gly Ser Phe Met Asn Leu Thr Arg Leu Gln Lys Leu 
                405                 410                 415     


Tyr Leu Asn Gly Asn His Leu Thr Lys Leu Ser Lys Gly Met Phe Leu 
            420                 425                 430         


Gly Leu His Asn Leu Glu Tyr Leu Tyr Leu Glu Tyr Asn Ala Ile Lys 
        435                 440                 445             


Glu Ile Leu Pro Gly Thr Phe Asn Pro Met Pro Lys Leu Lys Val Leu 
    450                 455                 460                 


Tyr Leu Asn Asn Asn Leu Leu Gln Val Leu Pro Pro His Ile Phe Ser 
465                 470                 475                 480 


Gly Val Pro Leu Thr Lys Val Asn Leu Lys Thr Asn Gln Phe Thr His 
                485                 490                 495     


Leu Pro Val Ser Asn Ile Leu Asp Asp Leu Asp Leu Leu Thr Gln Ile 
            500                 505                 510         


Asp Leu Glu Asp Asn Pro Trp Asp Cys Ser Cys Asp Leu Val Gly Leu 
        515                 520                 525             


Gln Gln Trp Ile Gln Lys Leu Ser Lys Asn Thr Val Thr Asp Asp Ile 
    530                 535                 540                 


Leu Cys Thr Ser Pro Gly His Leu Asp Lys Lys Glu Leu Lys Ala Leu 
545                 550                 555                 560 


Asn Ser Glu Ile Leu Cys Pro Gly Leu Val Asn Asn Pro Ser Met Pro 
                565                 570                 575     


Thr Gln Thr Ser Tyr Leu Met Val Thr Thr Pro Ala Thr Thr Thr Asn 
            580                 585                 590         


Thr Ala Asp Thr Ile Leu Arg Ser Leu Thr Asp Ala Val Pro Leu Ser 
        595                 600                 605             


Val Leu Ile Leu Gly Leu Leu Ile Met Phe Ile Thr Ile Val Phe Cys 
    610                 615                 620                 


Ala Ala Gly Ile Val Val Leu Val Leu His Arg Arg Arg Arg Tyr Lys 
625                 630                 635                 640 


Lys Lys Gln Val Asp Glu Gln Met Arg Asp Asn Ser Pro Val His Leu 
                645                 650                 655     


Gln Tyr Ser Met Tyr Gly His Lys Thr Thr His His Thr Thr Glu Arg 
            660                 665                 670         


Pro Ser Ala Ser Leu Tyr Glu Gln His Met Val Ser Pro Met Val His 
        675                 680                 685             


Val Tyr Arg Ser Pro Ser Phe Gly Pro Lys His Leu Glu Glu Glu Glu 
    690                 695                 700                 


Glu Arg Asn Glu Lys Glu Gly Ser Asp Ala Lys His Leu Gln Arg Ser 
705                 710                 715                 720 


Leu Leu Glu Gln Glu Asn His Ser Pro Leu Thr Gly Ser Asn Met Lys 
                725                 730                 735     


Tyr Lys Thr Thr Asn Gln Ser Thr Glu Phe Leu Ser Phe Gln Asp Ala 
            740                 745                 750         


Ser Ser Leu Tyr Arg Asn Ile Leu Glu Lys Glu Arg Glu Leu Gln Gln 
        755                 760                 765             


Leu Gly Ile Thr Glu Tyr Leu Arg Lys Asn Ile Ala Gln Leu Gln Pro 
    770                 775                 780                 


Asp Met Glu Ala His Tyr Pro Gly Ala His Glu Glu Leu Lys Leu Met 
785                 790                 795                 800 


Glu Thr Leu Met Tyr Ser Arg Pro Arg Lys Val Leu Val Glu Gln Thr 
                805                 810                 815     


Lys Asn Glu Tyr Phe Glu Leu Lys Ala Asn Leu His Ala Glu Pro Asp 
            820                 825                 830         


Tyr Leu Glu Val Leu Glu Gln Gln Thr 
        835                 840     


<210>  639
<211>  437
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(384)

<400>  639
atg ccg gag gtg tca tct aaa ggt gct acc att tcc aag aag ggc ttt         48
Met Pro Glu Val Ser Ser Lys Gly Ala Thr Ile Ser Lys Lys Gly Phe           
1               5                   10                  15                

aag aaa gct gtc gtt aag acc cag aaa aag gaa ggc aaa aag cgc aag         96
Lys Lys Ala Val Val Lys Thr Gln Lys Lys Glu Gly Lys Lys Arg Lys           
            20                  25                  30                    

agg acc cgt aag gag agt tat tct att tac atc tac aaa gtg cta aag        144
Arg Thr Arg Lys Glu Ser Tyr Ser Ile Tyr Ile Tyr Lys Val Leu Lys           
        35                  40                  45                        

cag gtc cat ccg gac act ggc atc tct tcg aaa gct atg agc att atg        192
Gln Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Ser Ile Met           
    50                  55                  60                            

aat tcc ttc gtc act gat atc ttt gag cgt ata gcg agc gag gca tca        240
Asn Ser Phe Val Thr Asp Ile Phe Glu Arg Ile Ala Ser Glu Ala Ser           
65                  70                  75                  80            

cgt ttg gct cac tac agc aag cgc tcc acc att tct tcc aga gag att        288
Arg Leu Ala His Tyr Ser Lys Arg Ser Thr Ile Ser Ser Arg Glu Ile           
                85                  90                  95                

cag aca gca gtg cgc ttg cta ctg ccg gga gag ctg gct aaa cat gct        336
Gln Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala           
            100                 105                 110                   

gtg tct gag ggc acc aag gct gtc act aag tac acc agc tcc aag taa        384
Val Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys               
        115                 120                 125                       

gcctgctaag taaacgtcat ttctaaccca aaggctcttt tcagagccac tta             437


<210>  640
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  640

Met Pro Glu Val Ser Ser Lys Gly Ala Thr Ile Ser Lys Lys Gly Phe 
1               5                   10                  15      


Lys Lys Ala Val Val Lys Thr Gln Lys Lys Glu Gly Lys Lys Arg Lys 
            20                  25                  30          


Arg Thr Arg Lys Glu Ser Tyr Ser Ile Tyr Ile Tyr Lys Val Leu Lys 
        35                  40                  45              


Gln Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Ser Ile Met 
    50                  55                  60                  


Asn Ser Phe Val Thr Asp Ile Phe Glu Arg Ile Ala Ser Glu Ala Ser 
65                  70                  75                  80  


Arg Leu Ala His Tyr Ser Lys Arg Ser Thr Ile Ser Ser Arg Glu Ile 
                85                  90                  95      


Gln Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala 
            100                 105                 110         


Val Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
        115                 120                 125         


<210>  641
<211>  4544
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (149)..(1942)

<400>  641
agcacaggca cgtcccgggg gctccagctt ctgctcagag cgcggagagc cgggccgggc       60

gggcgcgcgc gcaggactcg ggccgctcga ggggtccggc cggacggtgt cgggagccgg      120

acccgtcggc agaggagcgg gcgccgcg atg gct gag ggc agt gcc gtg tct         172
                               Met Ala Glu Gly Ser Ala Val Ser            
                               1               5                          

gac cct cag cac gcc gcg cgt ctg ctg cga gcg ctc agc tct ttc cgc        220
Asp Pro Gln His Ala Ala Arg Leu Leu Arg Ala Leu Ser Ser Phe Arg           
    10                  15                  20                            

gag gag tct cgc ttc tgc gac gcg cac ctg gtc ctc gac ggg gag gag        268
Glu Glu Ser Arg Phe Cys Asp Ala His Leu Val Leu Asp Gly Glu Glu           
25                  30                  35                  40            

atc ccg gtg cag aag aac atc ctg gcg gcg gcc agc ccg tac atc agg        316
Ile Pro Val Gln Lys Asn Ile Leu Ala Ala Ala Ser Pro Tyr Ile Arg           
                45                  50                  55                

aca aag tta aac tat aat cct cca aaa gat gat gga tca act tat aag        364
Thr Lys Leu Asn Tyr Asn Pro Pro Lys Asp Asp Gly Ser Thr Tyr Lys           
            60                  65                  70                    

att gaa ctt gaa ggg ata tcg gta atg gtt atg aga gag atc ctg gat        412
Ile Glu Leu Glu Gly Ile Ser Val Met Val Met Arg Glu Ile Leu Asp           
        75                  80                  85                        

tac atc ttc agt ggg cag atc agg cta aat gaa gat aca atc caa gat        460
Tyr Ile Phe Ser Gly Gln Ile Arg Leu Asn Glu Asp Thr Ile Gln Asp           
    90                  95                  100                           

gtt gtt cag gca gct gac ctg ctg cta ctg acg gac ctt aaa acc ctg        508
Val Val Gln Ala Ala Asp Leu Leu Leu Leu Thr Asp Leu Lys Thr Leu           
105                 110                 115                 120           

tgc tgt gag ttt ttg gaa ggc tgc att gct gct gag aac tgt att ggt        556
Cys Cys Glu Phe Leu Glu Gly Cys Ile Ala Ala Glu Asn Cys Ile Gly           
                125                 130                 135               

atc cgt gac ttt gca cta cat tac tgc ctc cat cac gtt cat tac ctt        604
Ile Arg Asp Phe Ala Leu His Tyr Cys Leu His His Val His Tyr Leu           
            140                 145                 150                   

gcc aca gaa tac ctg gag act cat ttc cga gac gtc agc agc acg gaa        652
Ala Thr Glu Tyr Leu Glu Thr His Phe Arg Asp Val Ser Ser Thr Glu           
        155                 160                 165                       

gaa ttc tta gag ctg agt cct caa aag ctt aaa gaa gtg att tct ctt        700
Glu Phe Leu Glu Leu Ser Pro Gln Lys Leu Lys Glu Val Ile Ser Leu           
    170                 175                 180                           

gag aag tta aac gtt ggc aat gaa aga tat gtc ttt gaa gca gta att        748
Glu Lys Leu Asn Val Gly Asn Glu Arg Tyr Val Phe Glu Ala Val Ile           
185                 190                 195                 200           

cga tgg ata gca cat gat aca gaa ata aga aag gtc cac atg aag gat        796
Arg Trp Ile Ala His Asp Thr Glu Ile Arg Lys Val His Met Lys Asp           
                205                 210                 215               

gtt atg tca gct ctg tgg gtt tca ggg ttg gac tcc agt tat tta cgg        844
Val Met Ser Ala Leu Trp Val Ser Gly Leu Asp Ser Ser Tyr Leu Arg           
            220                 225                 230                   

gaa cag atg ctg aat gaa cca tta gta cga gaa att gtc aaa gag tgt        892
Glu Gln Met Leu Asn Glu Pro Leu Val Arg Glu Ile Val Lys Glu Cys           
        235                 240                 245                       

agc aat ata ccg ctc agc cag ccg cag caa ggg gag gcg atg ctg gcc        940
Ser Asn Ile Pro Leu Ser Gln Pro Gln Gln Gly Glu Ala Met Leu Ala           
    250                 255                 260                           

aac ttc aaa ccc cgg ggc tac tct gag tgc atc gtg act gtt ggt gga        988
Asn Phe Lys Pro Arg Gly Tyr Ser Glu Cys Ile Val Thr Val Gly Gly           
265                 270                 275                 280           

gaa gag aga gtt tca cgg aaa ccc aca gca gcg atg cga tgc atg tgc       1036
Glu Glu Arg Val Ser Arg Lys Pro Thr Ala Ala Met Arg Cys Met Cys           
                285                 290                 295               

cct ctc tat gac cct aac agg cag ctt tgg atc gaa ctg gcc cct tta       1084
Pro Leu Tyr Asp Pro Asn Arg Gln Leu Trp Ile Glu Leu Ala Pro Leu           
            300                 305                 310                   

agc atg ccg aga att aac cat gga gtt ctc tca gca gaa gga ttt ttg       1132
Ser Met Pro Arg Ile Asn His Gly Val Leu Ser Ala Glu Gly Phe Leu           
        315                 320                 325                       

ttt gta ttc ggg ggc caa gat gaa aat aag cag act ctt agc tca gga       1180
Phe Val Phe Gly Gly Gln Asp Glu Asn Lys Gln Thr Leu Ser Ser Gly           
    330                 335                 340                           

gaa aag tat gat cca gat gca aat aca tgg aca gca ttg cca cct atg       1228
Glu Lys Tyr Asp Pro Asp Ala Asn Thr Trp Thr Ala Leu Pro Pro Met           
345                 350                 355                 360           

aac gag gca aga cat aac ttc gga att gtg gag ata gat ggg atg ctg       1276
Asn Glu Ala Arg His Asn Phe Gly Ile Val Glu Ile Asp Gly Met Leu           
                365                 370                 375               

tac att ttg gga gga gag gat ggt gaa aag gag ctg att tcc atg gag       1324
Tyr Ile Leu Gly Gly Glu Asp Gly Glu Lys Glu Leu Ile Ser Met Glu           
            380                 385                 390                   

tgt tac gat att tat tct aaa acc tgg aca aag caa cct gat ttg acc       1372
Cys Tyr Asp Ile Tyr Ser Lys Thr Trp Thr Lys Gln Pro Asp Leu Thr           
        395                 400                 405                       

atg gtc aga aag atc ggc tgc tat gca gct atg aaa aag aaa atc tac       1420
Met Val Arg Lys Ile Gly Cys Tyr Ala Ala Met Lys Lys Lys Ile Tyr           
    410                 415                 420                           

gcc atg ggt gga ggc tcc tac gga aag ctt ttt gag tct gta gag tgt       1468
Ala Met Gly Gly Gly Ser Tyr Gly Lys Leu Phe Glu Ser Val Glu Cys           
425                 430                 435                 440           

tat gat ccc agg acc cag cag tgg act gcc ata tgt cca cta aaa gag       1516
Tyr Asp Pro Arg Thr Gln Gln Trp Thr Ala Ile Cys Pro Leu Lys Glu           
                445                 450                 455               

agg agg ttt gga gcg gtg gcc tgt gga gtt gct atg gag ctg tat gtg       1564
Arg Arg Phe Gly Ala Val Ala Cys Gly Val Ala Met Glu Leu Tyr Val           
            460                 465                 470                   

ttt ggg gga gtc cga agt cgt gag gac gcc cag ggt agc gag atg gta       1612
Phe Gly Gly Val Arg Ser Arg Glu Asp Ala Gln Gly Ser Glu Met Val           
        475                 480                 485                       

act tgc aag tcc gag ttc tac cat gat gag ttt aaa agg tgg atc tat       1660
Thr Cys Lys Ser Glu Phe Tyr His Asp Glu Phe Lys Arg Trp Ile Tyr           
    490                 495                 500                           

ctt aac gac cag aat tta tgc atc ccc gcc agt tcc tct ttt gtt tat       1708
Leu Asn Asp Gln Asn Leu Cys Ile Pro Ala Ser Ser Ser Phe Val Tyr           
505                 510                 515                 520           

gga gct gta cct ata gga gcc agt att tat gtt att gga gat ctt gat       1756
Gly Ala Val Pro Ile Gly Ala Ser Ile Tyr Val Ile Gly Asp Leu Asp           
                525                 530                 535               

aca ggt acc aat tac gac tac gtg cgt gag ttt aaa aga agc aca gga       1804
Thr Gly Thr Asn Tyr Asp Tyr Val Arg Glu Phe Lys Arg Ser Thr Gly           
            540                 545                 550                   

acc tgg cac cac act aaa cca ctc ctt cca tcc gac ctt cgc cgt aca       1852
Thr Trp His His Thr Lys Pro Leu Leu Pro Ser Asp Leu Arg Arg Thr           
        555                 560                 565                       

gga tgt gca gcc tta cgc att gcg aat tgc aag ctt ttc cgc ctg cag       1900
Gly Cys Ala Ala Leu Arg Ile Ala Asn Cys Lys Leu Phe Arg Leu Gln           
    570                 575                 580                           

ctt cag caa ggc tta ttc cgt att cgt gtt cat tcc cct tga               1942
Leu Gln Gln Gly Leu Phe Arg Ile Arg Val His Ser Pro                       
585                 590                 595                               

ggaggaagca gagcagagtg cgagatcctg acccaagagc accataacat agctccgaaa     2002

gggagagcag agatggcagc tgaaactcac tctgtgctgg gctttggtat ggtaactctt     2062

tggtggtttt atgatgctta caaacttgag ctttagctct tgtttgggag aacacgtaac     2122

tgttgaaaaa ctacctggga ggagtgagtt cctccagtta aatgtggctg tagatgttgg     2182

aggctaggga ggctagtaaa tatcaaaagg aaaagggagt gggaattgct atcatgtaaa     2242

atatcaaagt taaaatacta aggtgcattt tccctgaagg gaactcatgt ctgactgctg     2302

tattcaaata cgtagctttg gtaacaaaca aaatccgtat atgcaaatca acatatccaa     2362

acatgccaag actgcttttc cactgcactt ggaaggatat attatgccta accctgccca     2422

acaaattaag gtttgtgcct aaaatgttag attggactgt atgccagtta gtctccattt     2482

attcctagta ctctgtccta agaatctttt taaaactata tcatgatgaa ttgaaatgaa     2542

gataaaattg ctcttttgta actttatctt agtaatgtaa agattcagta aattgatgag     2602

tcaggttgca gccctcatgt gaactgaaag aagttgctcg cttctgtgtt gacttagatc     2662

aagacacgtc acgcatcctt tctggggtag tacctgtgga gccgggaagg gtctcctgca     2722

gtgccattct gccttctcaa tgagcaaaac cattttctaa gtatgaggat attagtgagt     2782

aggagatttt ataaaagaaa gacctgagtc agacaaataa taaaggtctg ctgtggctaa     2842

aaaagcaaaa acaaaaaagc tatccagaca aaatacatag ggatcagaaa ctttttcata     2902

taacctgtct gaaagcacac aaagtcttgt ttactactgt ttagggtttg aaaacttgtc     2962

ttagaatgcg aatctgtgtt aagaatctag tctttgtaat agaagtttcc cagtggcatt     3022

cactagtgag agttttagac aaattatgtt acgagtaaag tttggctggt agaataaact     3082

acctcaactt aatttcattc tgttcatagt agagcaaatt aatcttttcc tccttccctc     3142

ctttcctatc tctcattctc acctcaaccc actttacccc acttctcatt gggggaaaaa     3202

tgtctttcgt tcgtggaacg tatcttgtaa gatattttgt tttccacttg aattacacca     3262

ccctagtgtg aaatcgggga cttcaaagtg cttgattcct tcctaaattg aattttatgc     3322

aatgtcaaat ttctaatcaa tttaatatac agtacttcat ttttaattgt tttctaaaaa     3382

aaaggttttt tttttccttt tggaatatgg ctgtaagaag cagcattttg tcttattaac     3442

acatgtataa aggtatcctt tggttttaag tcgagaacag gaatttcttc tagaaacttc     3502

ctgtatggaa cgtttatatg caattaacat gcatatgaaa aacatcactt acgttctccc     3562

acccatagac ataaaaaagg gtgacctgtg attttttttc ttatacctgc tggaagtcag     3622

tacaatgcgt caaaagttgc tgaaagatgc tgtgcctatg gggttctaga gagtgttgag     3682

tgtggtacat taactctcca ttttagccag aagatacctg ataagagaag gtgtaaggtt     3742

tttatcttat atgccagagg caccaggcca gatgtgccgc acagtcatgt aattcaatca     3802

tgtttaatat gtcagtcaaa accaaattca gaattgtttt gtgtaccagt cagctgttgt     3862

ctgcacattt tcgtagtgac agtgtggaga tctttttaat gaaagcaaac tatgtggcct     3922

ctgcaaagaa aggaagattt ttctttttac aactagatat tagttttaga ggaaggaaat     3982

agctgaaaaa ctaaatttgc tttggtgaaa tgtcctgtac agaacagtac cttggcattc     4042

agcagctgta attggggaac attaaaacag taactgacat ccagttaaag ccacgatcgt     4102

cagcaattct ccttttttaa tttctgatat ttaaagtttt ttttccagtc tacaccaggc     4162

ctctccaagg agacagttca ttatttagga gtgaatgtgt tcctcttgca atattatcag     4222

tacctgcatg acttggtaaa ttcattttat aaaaatagtg tttttttttt ttaatttcag     4282

ttcattgact ctataactgc agaaattaga taatgtttta taaaataaat ttgccacata     4342

atatgggatg caataaccaa caaagctgct aagtgccaaa ctgttatttt actatatata     4402

aatattaaaa tattgtgttg aagtataggg atgtatttaa ttttactatg ctccaacatt     4462

aatcatgact cttttgtaaa ttacagttat ttcagtattg taaaataaat gttgactcat     4522

ttcatgcagg tttgtgtttt aa                                              4544


<210>  642
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  642

Met Ala Glu Gly Ser Ala Val Ser Asp Pro Gln His Ala Ala Arg Leu 
1               5                   10                  15      


Leu Arg Ala Leu Ser Ser Phe Arg Glu Glu Ser Arg Phe Cys Asp Ala 
            20                  25                  30          


His Leu Val Leu Asp Gly Glu Glu Ile Pro Val Gln Lys Asn Ile Leu 
        35                  40                  45              


Ala Ala Ala Ser Pro Tyr Ile Arg Thr Lys Leu Asn Tyr Asn Pro Pro 
    50                  55                  60                  


Lys Asp Asp Gly Ser Thr Tyr Lys Ile Glu Leu Glu Gly Ile Ser Val 
65                  70                  75                  80  


Met Val Met Arg Glu Ile Leu Asp Tyr Ile Phe Ser Gly Gln Ile Arg 
                85                  90                  95      


Leu Asn Glu Asp Thr Ile Gln Asp Val Val Gln Ala Ala Asp Leu Leu 
            100                 105                 110         


Leu Leu Thr Asp Leu Lys Thr Leu Cys Cys Glu Phe Leu Glu Gly Cys 
        115                 120                 125             


Ile Ala Ala Glu Asn Cys Ile Gly Ile Arg Asp Phe Ala Leu His Tyr 
    130                 135                 140                 


Cys Leu His His Val His Tyr Leu Ala Thr Glu Tyr Leu Glu Thr His 
145                 150                 155                 160 


Phe Arg Asp Val Ser Ser Thr Glu Glu Phe Leu Glu Leu Ser Pro Gln 
                165                 170                 175     


Lys Leu Lys Glu Val Ile Ser Leu Glu Lys Leu Asn Val Gly Asn Glu 
            180                 185                 190         


Arg Tyr Val Phe Glu Ala Val Ile Arg Trp Ile Ala His Asp Thr Glu 
        195                 200                 205             


Ile Arg Lys Val His Met Lys Asp Val Met Ser Ala Leu Trp Val Ser 
    210                 215                 220                 


Gly Leu Asp Ser Ser Tyr Leu Arg Glu Gln Met Leu Asn Glu Pro Leu 
225                 230                 235                 240 


Val Arg Glu Ile Val Lys Glu Cys Ser Asn Ile Pro Leu Ser Gln Pro 
                245                 250                 255     


Gln Gln Gly Glu Ala Met Leu Ala Asn Phe Lys Pro Arg Gly Tyr Ser 
            260                 265                 270         


Glu Cys Ile Val Thr Val Gly Gly Glu Glu Arg Val Ser Arg Lys Pro 
        275                 280                 285             


Thr Ala Ala Met Arg Cys Met Cys Pro Leu Tyr Asp Pro Asn Arg Gln 
    290                 295                 300                 


Leu Trp Ile Glu Leu Ala Pro Leu Ser Met Pro Arg Ile Asn His Gly 
305                 310                 315                 320 


Val Leu Ser Ala Glu Gly Phe Leu Phe Val Phe Gly Gly Gln Asp Glu 
                325                 330                 335     


Asn Lys Gln Thr Leu Ser Ser Gly Glu Lys Tyr Asp Pro Asp Ala Asn 
            340                 345                 350         


Thr Trp Thr Ala Leu Pro Pro Met Asn Glu Ala Arg His Asn Phe Gly 
        355                 360                 365             


Ile Val Glu Ile Asp Gly Met Leu Tyr Ile Leu Gly Gly Glu Asp Gly 
    370                 375                 380                 


Glu Lys Glu Leu Ile Ser Met Glu Cys Tyr Asp Ile Tyr Ser Lys Thr 
385                 390                 395                 400 


Trp Thr Lys Gln Pro Asp Leu Thr Met Val Arg Lys Ile Gly Cys Tyr 
                405                 410                 415     


Ala Ala Met Lys Lys Lys Ile Tyr Ala Met Gly Gly Gly Ser Tyr Gly 
            420                 425                 430         


Lys Leu Phe Glu Ser Val Glu Cys Tyr Asp Pro Arg Thr Gln Gln Trp 
        435                 440                 445             


Thr Ala Ile Cys Pro Leu Lys Glu Arg Arg Phe Gly Ala Val Ala Cys 
    450                 455                 460                 


Gly Val Ala Met Glu Leu Tyr Val Phe Gly Gly Val Arg Ser Arg Glu 
465                 470                 475                 480 


Asp Ala Gln Gly Ser Glu Met Val Thr Cys Lys Ser Glu Phe Tyr His 
                485                 490                 495     


Asp Glu Phe Lys Arg Trp Ile Tyr Leu Asn Asp Gln Asn Leu Cys Ile 
            500                 505                 510         


Pro Ala Ser Ser Ser Phe Val Tyr Gly Ala Val Pro Ile Gly Ala Ser 
        515                 520                 525             


Ile Tyr Val Ile Gly Asp Leu Asp Thr Gly Thr Asn Tyr Asp Tyr Val 
    530                 535                 540                 


Arg Glu Phe Lys Arg Ser Thr Gly Thr Trp His His Thr Lys Pro Leu 
545                 550                 555                 560 


Leu Pro Ser Asp Leu Arg Arg Thr Gly Cys Ala Ala Leu Arg Ile Ala 
                565                 570                 575     


Asn Cys Lys Leu Phe Arg Leu Gln Leu Gln Gln Gly Leu Phe Arg Ile 
            580                 585                 590         


Arg Val His Ser Pro 
        595         


<210>  643
<211>  1999
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (725)..(1300)

<400>  643
tattctaatg gagagaaacg cacgtgcaca cacacccccc taaacccaca caaatgaaac       60

cccctctgcg gagaagccgg ctacaggaaa ttgacttagg cacaggaact tgctaatctc      120

ttttgtcaca ttcggattgc tcctgctgcc ccacacacac taacccaacc atcttggggt      180

ggactccctg ccagcccaac tgttgtattt tcagttcttc cagtgtgaat cagttaatat      240

tctcgggaac gagggagagg ttgatcctat gaggaaatca accacagtga aaaggcttgg      300

gccgcttttg ttttcacctg cttttgttga acaaatttga tttccggagt cagtcatttt      360

actgtcaaga catttcttcg gcattctgca acagtttcca acatggctag atccatcaga      420

aactgaagcc gtggagaacg ctctcggggc ctttgccact tcttggagta gaagccgaca      480

gagagctgtt tggaaacttc tccttcacac accagttgaa gactaggctt tggaggtttt      540

caaagcagac ggtgcttgga tgggcaggga gaagtaacat tctgcaaatc gccgtcagag      600

gtcctgagga cacagaccta cctggcttgc attccccttg ctgaatggcg tgtgctgcag      660

ctgcccactg agggctcttt tccctgggat tctggacttc agagtaggac agcaggctgg      720

gaag atg ctg agt tcc atc aag tgc gtg ttg gtg ggc gac tct gct gtg       769
     Met Leu Ser Ser Ile Lys Cys Val Leu Val Gly Asp Ser Ala Val          
     1               5                   10                  15           

ggg aaa acc tct ctg ttg gtg cgc ttc acc tcc gag acc ttc ccg gag        817
Gly Lys Thr Ser Leu Leu Val Arg Phe Thr Ser Glu Thr Phe Pro Glu           
                20                  25                  30                

gcc tac aag ccc aca gtg tac gag aac aca ggg gtg gac gtc ttc atg        865
Ala Tyr Lys Pro Thr Val Tyr Glu Asn Thr Gly Val Asp Val Phe Met           
            35                  40                  45                    

gat ggc atc cag atc agc ctg ggc ctc tgg gac aca gcc ggc aat gac        913
Asp Gly Ile Gln Ile Ser Leu Gly Leu Trp Asp Thr Ala Gly Asn Asp           
        50                  55                  60                        

gcc ttc aga agc atc cgg ccc ctg tcc tac cag cag gca gac gtg gtg        961
Ala Phe Arg Ser Ile Arg Pro Leu Ser Tyr Gln Gln Ala Asp Val Val           
    65                  70                  75                            

ctg atg tgc tac tct gtg gcc aac cat aac tca ttc ctg aac ttg aag       1009
Leu Met Cys Tyr Ser Val Ala Asn His Asn Ser Phe Leu Asn Leu Lys           
80                  85                  90                  95            

aac aag tgg att ggt gaa att agg agc aac ttg ccc tgt acc cct gtg       1057
Asn Lys Trp Ile Gly Glu Ile Arg Ser Asn Leu Pro Cys Thr Pro Val           
                100                 105                 110               

ctg gtg gtg gcc acc cag act gac cag cgg gag atg ggg ccc cac agg       1105
Leu Val Val Ala Thr Gln Thr Asp Gln Arg Glu Met Gly Pro His Arg           
            115                 120                 125                   

gcc tcc tgc gtc aat gcc atg gaa ggg aag aaa ctg gcc cag gat gtc       1153
Ala Ser Cys Val Asn Ala Met Glu Gly Lys Lys Leu Ala Gln Asp Val           
        130                 135                 140                       

aga gcc aag ggc tac ctg gag tgc tca gcc ctt agc aat cgg gga gta       1201
Arg Ala Lys Gly Tyr Leu Glu Cys Ser Ala Leu Ser Asn Arg Gly Val           
    145                 150                 155                           

cag cag gtg ttt gag tgc gcc gtc cga act gcc gtc aac cag gcc agg       1249
Gln Gln Val Phe Glu Cys Ala Val Arg Thr Ala Val Asn Gln Ala Arg           
160                 165                 170                 175           

aga cga aac aga agg agg ctc ttc tcc atc aat gag tgc aag atc ttc       1297
Arg Arg Asn Arg Arg Arg Leu Phe Ser Ile Asn Glu Cys Lys Ile Phe           
                180                 185                 190               

taa accccaagag acttcacaca acacttatgt atgcacccca aagactaatg            1350

gggagaggga gggccgggaa gccaggaaag cttggtgttt tctctgggta caccccaagc     1410

agcgtctcct tttggataca gttattgatg aggcttggcc actggatgtt ttcactaact     1470

acactctaca agtgaactcc ttgcccaggc cagttagaaa atcccttggg gaactgtgat     1530

gaatattcca tctttgatta aaaaagtgaa atagtctcca taattttgga cgatgaagtg     1590

agtttttcaa agaattccat atttaaagac acattttatt taactaataa caaaatgtat     1650

tgcttttgta tatatttagt tttcacactt ggaaaatctt ttcctacatc ctcgaaaaca     1710

taaactcctc tgtgagtgaa atgcttgtac gaagctctgc catatgtttg tagtgttatt     1770

attttcacct caagtagaaa gtctgttgaa accacttggc tgctggattt aaatgggtaa     1830

tcaaatttaa aaatgaccat aaatgaatct ttgcaatttg ttttctactt acctgttatt     1890

cacagttgga tataaaatac agttccataa gatatcctaa tactgcctaa tgattttaaa     1950

gttatcacta tatttttctg aaatgataaa acatcattca tttatttac                 1999


<210>  644
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  644

Met Leu Ser Ser Ile Lys Cys Val Leu Val Gly Asp Ser Ala Val Gly 
1               5                   10                  15      


Lys Thr Ser Leu Leu Val Arg Phe Thr Ser Glu Thr Phe Pro Glu Ala 
            20                  25                  30          


Tyr Lys Pro Thr Val Tyr Glu Asn Thr Gly Val Asp Val Phe Met Asp 
        35                  40                  45              


Gly Ile Gln Ile Ser Leu Gly Leu Trp Asp Thr Ala Gly Asn Asp Ala 
    50                  55                  60                  


Phe Arg Ser Ile Arg Pro Leu Ser Tyr Gln Gln Ala Asp Val Val Leu 
65                  70                  75                  80  


Met Cys Tyr Ser Val Ala Asn His Asn Ser Phe Leu Asn Leu Lys Asn 
                85                  90                  95      


Lys Trp Ile Gly Glu Ile Arg Ser Asn Leu Pro Cys Thr Pro Val Leu 
            100                 105                 110         


Val Val Ala Thr Gln Thr Asp Gln Arg Glu Met Gly Pro His Arg Ala 
        115                 120                 125             


Ser Cys Val Asn Ala Met Glu Gly Lys Lys Leu Ala Gln Asp Val Arg 
    130                 135                 140                 


Ala Lys Gly Tyr Leu Glu Cys Ser Ala Leu Ser Asn Arg Gly Val Gln 
145                 150                 155                 160 


Gln Val Phe Glu Cys Ala Val Arg Thr Ala Val Asn Gln Ala Arg Arg 
                165                 170                 175     


Arg Asn Arg Arg Arg Leu Phe Ser Ile Asn Glu Cys Lys Ile Phe 
            180                 185                 190     


<210>  645
<211>  1609
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1215)

<400>  645
atg gaa aga ggc tgg ttc cat ggg aaa gga ttc ctc ctt ggc ttc atc         48
Met Glu Arg Gly Trp Phe His Gly Lys Gly Phe Leu Leu Gly Phe Ile           
1               5                   10                  15                

ctc cac ctg ctg ctg caa gat tca cac ctt caa ctg gtg aca tcg ttc         96
Leu His Leu Leu Leu Gln Asp Ser His Leu Gln Leu Val Thr Ser Phe           
            20                  25                  30                    

ctg tgg cta aat atg tgg aac cca gat gaa tgc gga ggc atc aag aag        144
Leu Trp Leu Asn Met Trp Asn Pro Asp Glu Cys Gly Gly Ile Lys Lys           
        35                  40                  45                        

tcc ggc atg gca act gag aac cta tgg ctt tca gat gtc ttc atc gag        192
Ser Gly Met Ala Thr Glu Asn Leu Trp Leu Ser Asp Val Phe Ile Glu           
    50                  55                  60                            

gag tct gtg gat cag aca cct gca ggt ctc atg gct agt atg tca ata        240
Glu Ser Val Asp Gln Thr Pro Ala Gly Leu Met Ala Ser Met Ser Ile           
65                  70                  75                  80            

gtg aag gcc aca tca aac aca ata agc caa tgt ggg tgg tca gca tct        288
Val Lys Ala Thr Ser Asn Thr Ile Ser Gln Cys Gly Trp Ser Ala Ser           
                85                  90                  95                

gca aac tgg aca cct tct att tcc cct tcc atg gac aga ggt gaa cgc        336
Ala Asn Trp Thr Pro Ser Ile Ser Pro Ser Met Asp Arg Gly Glu Arg           
            100                 105                 110                   

tct cct tca gcc ctt tca cct aca cag gta acc cgg gca tgg aga agg        384
Ser Pro Ser Ala Leu Ser Pro Thr Gln Val Thr Arg Ala Trp Arg Arg           
        115                 120                 125                       

atg tcc agg agc ttt caa ata cat cac aga acc tca ttc aga aca agg        432
Met Ser Arg Ser Phe Gln Ile His His Arg Thr Ser Phe Arg Thr Arg           
    130                 135                 140                           

agg gag tgg gta ctg ctg ggt atc caa aaa aga aca ata aag gtg acc        480
Arg Glu Trp Val Leu Leu Gly Ile Gln Lys Arg Thr Ile Lys Val Thr           
145                 150                 155                 160           

gtg gcc act aac cag tat gaa caa gcc atc ttc cat gtg gcc atc agg        528
Val Ala Thr Asn Gln Tyr Glu Gln Ala Ile Phe His Val Ala Ile Arg           
                165                 170                 175               

cgc agg tgc agg ccc agc ccc tac gtg gta aac ttt ctg gtg ccc agt        576
Arg Arg Cys Arg Pro Ser Pro Tyr Val Val Asn Phe Leu Val Pro Ser           
            180                 185                 190                   

ggc att ctg att gcc atc gat gcc ctc agt ttc tac ctg cca ctg gaa        624
Gly Ile Leu Ile Ala Ile Asp Ala Leu Ser Phe Tyr Leu Pro Leu Glu           
        195                 200                 205                       

agt ggg aat tgt gcc cca ttc aag atg act gtt ctg ctg ggc tac agc        672
Ser Gly Asn Cys Ala Pro Phe Lys Met Thr Val Leu Leu Gly Tyr Ser           
    210                 215                 220                           

gtc ttc ctg ctc atg atg aat gac ttg ctc cca gcc act agc act tca        720
Val Phe Leu Leu Met Met Asn Asp Leu Leu Pro Ala Thr Ser Thr Ser           
225                 230                 235                 240           

tca cat gct tca cta gta cgt cct cat cca tca aga gac caa aag cga        768
Ser His Ala Ser Leu Val Arg Pro His Pro Ser Arg Asp Gln Lys Arg           
                245                 250                 255               

ggt gtc tac ttc gcc ctg tgc ctg tcc ctg atg gtg ggc agc ctg ctg        816
Gly Val Tyr Phe Ala Leu Cys Leu Ser Leu Met Val Gly Ser Leu Leu           
            260                 265                 270                   

gag acc atc ttc atc acc cac ctg ctg cac gtg gcc acc acc cag ccc        864
Glu Thr Ile Phe Ile Thr His Leu Leu His Val Ala Thr Thr Gln Pro           
        275                 280                 285                       

cta cct ctg cct cgg tgg ctc cac tcc ctg ctg ctg cac tgc acc ggc        912
Leu Pro Leu Pro Arg Trp Leu His Ser Leu Leu Leu His Cys Thr Gly           
    290                 295                 300                           

caa ggg aga tgc tgt ccc act gcg ccc cag aag gga aat aag ggc ccg        960
Gln Gly Arg Cys Cys Pro Thr Ala Pro Gln Lys Gly Asn Lys Gly Pro           
305                 310                 315                 320           

ggt ctc acc ccc acc cac ctg ccc ggt gtg aag gag cca gag gta tca       1008
Gly Leu Thr Pro Thr His Leu Pro Gly Val Lys Glu Pro Glu Val Ser           
                325                 330                 335               

gca ggg cag atg cca ggc cct ggg gag gca gag ctg aca ggg ggc tca       1056
Ala Gly Gln Met Pro Gly Pro Gly Glu Ala Glu Leu Thr Gly Gly Ser           
            340                 345                 350                   

gaa tgg aca agg gcc cag cgg gaa cac gag gcc cag aag cag cac tcg       1104
Glu Trp Thr Arg Ala Gln Arg Glu His Glu Ala Gln Lys Gln His Ser           
        355                 360                 365                       

gtg gag ctg tgg gtg cag ttc agc cac gcg atg gac gcc ctg ctc ttc       1152
Val Glu Leu Trp Val Gln Phe Ser His Ala Met Asp Ala Leu Leu Phe           
    370                 375                 380                           

cgc ctc tac ctg ctc ttc atg gcc tcc tcc atc atc acc gtc ata tgc       1200
Arg Leu Tyr Leu Leu Phe Met Ala Ser Ser Ile Ile Thr Val Ile Cys           
385                 390                 395                 400           

ctc tgg aac acc tag gcaggtgctc acctgcaaac ttcagtctgg acttcttttt       1255
Leu Trp Asn Thr                                                           
                                                                          

gccagagaac tccagaaacc agtcaggctc tcagtcagcc ttgtggccct gtcaaccgcc     1315

tcatttttaa cccagtcctc tgtgtagttt cagaccagac ctgaatagtc tcctatgccc     1375

tccaaaagtc gggtccttgc tcctgcatgc catcagcccc actcagccct cccatacctc     1435

cctggctcct caggattcag gttcctaggg tacgtccttg attaaatcac cccaatatgc     1495

ccctttgcag aaagtattgg cttttccctg aattctgtta tggtaaaaaa aatcttggga     1555

ttgagagtct tcttgcagaa acttctcagc caaagtaaaa aggattttct ctta           1609


<210>  646
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  646

Met Glu Arg Gly Trp Phe His Gly Lys Gly Phe Leu Leu Gly Phe Ile 
1               5                   10                  15      


Leu His Leu Leu Leu Gln Asp Ser His Leu Gln Leu Val Thr Ser Phe 
            20                  25                  30          


Leu Trp Leu Asn Met Trp Asn Pro Asp Glu Cys Gly Gly Ile Lys Lys 
        35                  40                  45              


Ser Gly Met Ala Thr Glu Asn Leu Trp Leu Ser Asp Val Phe Ile Glu 
    50                  55                  60                  


Glu Ser Val Asp Gln Thr Pro Ala Gly Leu Met Ala Ser Met Ser Ile 
65                  70                  75                  80  


Val Lys Ala Thr Ser Asn Thr Ile Ser Gln Cys Gly Trp Ser Ala Ser 
                85                  90                  95      


Ala Asn Trp Thr Pro Ser Ile Ser Pro Ser Met Asp Arg Gly Glu Arg 
            100                 105                 110         


Ser Pro Ser Ala Leu Ser Pro Thr Gln Val Thr Arg Ala Trp Arg Arg 
        115                 120                 125             


Met Ser Arg Ser Phe Gln Ile His His Arg Thr Ser Phe Arg Thr Arg 
    130                 135                 140                 


Arg Glu Trp Val Leu Leu Gly Ile Gln Lys Arg Thr Ile Lys Val Thr 
145                 150                 155                 160 


Val Ala Thr Asn Gln Tyr Glu Gln Ala Ile Phe His Val Ala Ile Arg 
                165                 170                 175     


Arg Arg Cys Arg Pro Ser Pro Tyr Val Val Asn Phe Leu Val Pro Ser 
            180                 185                 190         


Gly Ile Leu Ile Ala Ile Asp Ala Leu Ser Phe Tyr Leu Pro Leu Glu 
        195                 200                 205             


Ser Gly Asn Cys Ala Pro Phe Lys Met Thr Val Leu Leu Gly Tyr Ser 
    210                 215                 220                 


Val Phe Leu Leu Met Met Asn Asp Leu Leu Pro Ala Thr Ser Thr Ser 
225                 230                 235                 240 


Ser His Ala Ser Leu Val Arg Pro His Pro Ser Arg Asp Gln Lys Arg 
                245                 250                 255     


Gly Val Tyr Phe Ala Leu Cys Leu Ser Leu Met Val Gly Ser Leu Leu 
            260                 265                 270         


Glu Thr Ile Phe Ile Thr His Leu Leu His Val Ala Thr Thr Gln Pro 
        275                 280                 285             


Leu Pro Leu Pro Arg Trp Leu His Ser Leu Leu Leu His Cys Thr Gly 
    290                 295                 300                 


Gln Gly Arg Cys Cys Pro Thr Ala Pro Gln Lys Gly Asn Lys Gly Pro 
305                 310                 315                 320 


Gly Leu Thr Pro Thr His Leu Pro Gly Val Lys Glu Pro Glu Val Ser 
                325                 330                 335     


Ala Gly Gln Met Pro Gly Pro Gly Glu Ala Glu Leu Thr Gly Gly Ser 
            340                 345                 350         


Glu Trp Thr Arg Ala Gln Arg Glu His Glu Ala Gln Lys Gln His Ser 
        355                 360                 365             


Val Glu Leu Trp Val Gln Phe Ser His Ala Met Asp Ala Leu Leu Phe 
    370                 375                 380                 


Arg Leu Tyr Leu Leu Phe Met Ala Ser Ser Ile Ile Thr Val Ile Cys 
385                 390                 395                 400 


Leu Trp Asn Thr 
                


<210>  647
<211>  2144
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (34)..(1641)

<400>  647
cctctcatcc tgccctccgg cccctctgca gct atg agg tcc tcc gtc tct cgg        54
                                     Met Arg Ser Ser Val Ser Arg          
                                     1               5                    

caa aca tac tcc aca aaa ggg ggc ttc agc tcc aac tct gcc agc gga        102
Gln Thr Tyr Ser Thr Lys Gly Gly Phe Ser Ser Asn Ser Ala Ser Gly           
        10                  15                  20                        

ggg agt ggg tcc cag gcc cgc acc agc ttc agc tca gtg acg gtg tct        150
Gly Ser Gly Ser Gln Ala Arg Thr Ser Phe Ser Ser Val Thr Val Ser           
    25                  30                  35                            

cgg agc agt ggc agt ggt ggc ggg gcc cac tgt ggc ccc ggc aca ggt        198
Arg Ser Ser Gly Ser Gly Gly Gly Ala His Cys Gly Pro Gly Thr Gly           
40                  45                  50                  55            

ggc ttt ggc agc cga agc ctc tat aac ttg ggg ggc cac aag agt atc        246
Gly Phe Gly Ser Arg Ser Leu Tyr Asn Leu Gly Gly His Lys Ser Ile           
                60                  65                  70                

tct gtc agt gtg gcc gga ggg gcc ttg ttg ggg cgg gct ctg ggg ggc        294
Ser Val Ser Val Ala Gly Gly Ala Leu Leu Gly Arg Ala Leu Gly Gly           
            75                  80                  85                    

ttt ggc ttt ggc agc agg gca ttt atg gga cag ggg gct ggc agg cag        342
Phe Gly Phe Gly Ser Arg Ala Phe Met Gly Gln Gly Ala Gly Arg Gln           
        90                  95                  100                       

acg ttt ggg cct gct tgt cct cct ggg ggg atc cag gag gtc act gtc        390
Thr Phe Gly Pro Ala Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val           
    105                 110                 115                           

aac cag agc ctg ctg acc ccc ctc cat gtg gag att gac ccc gag atc        438
Asn Gln Ser Leu Leu Thr Pro Leu His Val Glu Ile Asp Pro Glu Ile           
120                 125                 130                 135           

cag cga gtg cgc act cag gag cgg gag cag atc aag acc ctc aac aac        486
Gln Arg Val Arg Thr Gln Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn           
                140                 145                 150               

aag ttc gcc tcc ttc atc gac aag gtg cgg ttc ctg gag caa cag aat        534
Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn           
            155                 160                 165                   

aag gtg ctg gag acc aag tgg gca ctg ctg cag gag cag ggc cag aac        582
Lys Val Leu Glu Thr Lys Trp Ala Leu Leu Gln Glu Gln Gly Gln Asn           
        170                 175                 180                       

ttg ggt gtc acc agg aac aac ctg gag ccc ctc ttt gag gcc tac ctg        630
Leu Gly Val Thr Arg Asn Asn Leu Glu Pro Leu Phe Glu Ala Tyr Leu           
    185                 190                 195                           

ggt agc atg cgg agc acg ctg gac aga ctt cag agc gag cgg ggg agg        678
Gly Ser Met Arg Ser Thr Leu Asp Arg Leu Gln Ser Glu Arg Gly Arg           
200                 205                 210                 215           

ctg gac tca gag ctc agg aac gtg cag gac ctt gtg gag gac ttc aag        726
Leu Asp Ser Glu Leu Arg Asn Val Gln Asp Leu Val Glu Asp Phe Lys           
                220                 225                 230               

aac aag tac gag gat gaa atc aac aag cac act gct gca gag aac gag        774
Asn Lys Tyr Glu Asp Glu Ile Asn Lys His Thr Ala Ala Glu Asn Glu           
            235                 240                 245                   

ttt gtg gtg ctc aag aag gat gtg gat gca gca tac atg ggc cgg atg        822
Phe Val Val Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Gly Arg Met           
        250                 255                 260                       

gat ctg cat ggc aaa gtg ggc acc ttg acc cag gag att gac ttc ctg        870
Asp Leu His Gly Lys Val Gly Thr Leu Thr Gln Glu Ile Asp Phe Leu           
    265                 270                 275                           

cag caa ctc tat gaa atg gag ctg agc caa gtg cag acc cac gtg tct        918
Gln Gln Leu Tyr Glu Met Glu Leu Ser Gln Val Gln Thr His Val Ser           
280                 285                 290                 295           

aac acc aat gtg gtg ctg tcc atg gac aac aac cgc aac ctg gac ctg        966
Asn Thr Asn Val Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu           
                300                 305                 310               

gac agc atc atc gcc gag gtc aag gcc cag tat gag ctg att gcc cag       1014
Asp Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Leu Ile Ala Gln           
            315                 320                 325                   

agg agc cgg gct gag gcc gag gcc tgg tac cag acc aag tat gag gag       1062
Arg Ser Arg Ala Glu Ala Glu Ala Trp Tyr Gln Thr Lys Tyr Glu Glu           
        330                 335                 340                       

ctg cag gtg act gct ggg aag cat ggg gac aac ctg cgg gac acc aag       1110
Leu Gln Val Thr Ala Gly Lys His Gly Asp Asn Leu Arg Asp Thr Lys           
    345                 350                 355                           

aac gag att gct gag ctc acc cgc act atc cag agg ctg cag ggg gag       1158
Asn Glu Ile Ala Glu Leu Thr Arg Thr Ile Gln Arg Leu Gln Gly Glu           
360                 365                 370                 375           

gct gat gca gcc aag aag cag tgt cag cag ctg cag acg gcc att gcg       1206
Ala Asp Ala Ala Lys Lys Gln Cys Gln Gln Leu Gln Thr Ala Ile Ala           
                380                 385                 390               

gaa gcg gag cag cgt ggg gag ctg gca ctc aag gat gct cag aag aag       1254
Glu Ala Glu Gln Arg Gly Glu Leu Ala Leu Lys Asp Ala Gln Lys Lys           
            395                 400                 405                   

ctt ggg gat ctg gat gtg gcc ctg cac cag gcc aag gag gac ctg aca       1302
Leu Gly Asp Leu Asp Val Ala Leu His Gln Ala Lys Glu Asp Leu Thr           
        410                 415                 420                       

cgg ctg ctg cgt gac tac cag gag ctg atg aat gtc aag ctg gcc ctg       1350
Arg Leu Leu Arg Asp Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu           
    425                 430                 435                           

gac gtg gag att gcc acc tac cgc aag ctt ctg gag agc gag gag agc       1398
Asp Val Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Ser Glu Glu Ser           
440                 445                 450                 455           

agg atg tct gga gaa tgt ccc agt gca gtc agc att tct gtg act ggc       1446
Arg Met Ser Gly Glu Cys Pro Ser Ala Val Ser Ile Ser Val Thr Gly           
                460                 465                 470               

aac tcc acc act gtg tgc gga ggt ggc gca gcc agc ttt gga ggt ggc       1494
Asn Ser Thr Thr Val Cys Gly Gly Gly Ala Ala Ser Phe Gly Gly Gly           
            475                 480                 485                   

atc tcc ctg ggt ggg agt ggg ggg gcc acc aag ggt gga ttc agc aca       1542
Ile Ser Leu Gly Gly Ser Gly Gly Ala Thr Lys Gly Gly Phe Ser Thr           
        490                 495                 500                       

aat gtg ggc tat agc acc gtc aag gga ggg cca gtc tct gcg ggc acc       1590
Asn Val Gly Tyr Ser Thr Val Lys Gly Gly Pro Val Ser Ala Gly Thr           
    505                 510                 515                           

tcc atc ctg cgg aag acc act acg gtc aag acg tcc agc cag agg tat       1638
Ser Ile Leu Arg Lys Thr Thr Thr Val Lys Thr Ser Ser Gln Arg Tyr           
520                 525                 530                 535           

tag ctgctgagcc ctgcaagggc ccctgcaatc ctgtccctgc cctcctcacc            1691

ccacctctgc tgtcctttcc agtcacttct caggagcagg aacagccagg ggacctcaga     1751

cccagggtat tttcatacca gactatttgc atcttgggaa gcgctcaaat ctactcaggt     1811

tttctccttg gtcctgcagt aggatgggag ggaaggttaa agttgccagc ttgagtgatg     1871

tgcttgggtg acttgggggt gaccttttga ccaccgagag gaggctgaat ttctcaagcc     1931

attaggagag agagaaattg ggagtggtcc ccaaagaccc ttcaacctcc ccagtccccc     1991

accagaccca ccctctccct gaatctaccc acatccccct tccctgtctg tgtctcaata     2051

aatggtgcaa ctgcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2111

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                  2144


<210>  648
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  648

Met Arg Ser Ser Val Ser Arg Gln Thr Tyr Ser Thr Lys Gly Gly Phe 
1               5                   10                  15      


Ser Ser Asn Ser Ala Ser Gly Gly Ser Gly Ser Gln Ala Arg Thr Ser 
            20                  25                  30          


Phe Ser Ser Val Thr Val Ser Arg Ser Ser Gly Ser Gly Gly Gly Ala 
        35                  40                  45              


His Cys Gly Pro Gly Thr Gly Gly Phe Gly Ser Arg Ser Leu Tyr Asn 
    50                  55                  60                  


Leu Gly Gly His Lys Ser Ile Ser Val Ser Val Ala Gly Gly Ala Leu 
65                  70                  75                  80  


Leu Gly Arg Ala Leu Gly Gly Phe Gly Phe Gly Ser Arg Ala Phe Met 
                85                  90                  95      


Gly Gln Gly Ala Gly Arg Gln Thr Phe Gly Pro Ala Cys Pro Pro Gly 
            100                 105                 110         


Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu Leu Thr Pro Leu His 
        115                 120                 125             


Val Glu Ile Asp Pro Glu Ile Gln Arg Val Arg Thr Gln Glu Arg Glu 
    130                 135                 140                 


Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val 
145                 150                 155                 160 


Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Glu Thr Lys Trp Ala Leu 
                165                 170                 175     


Leu Gln Glu Gln Gly Gln Asn Leu Gly Val Thr Arg Asn Asn Leu Glu 
            180                 185                 190         


Pro Leu Phe Glu Ala Tyr Leu Gly Ser Met Arg Ser Thr Leu Asp Arg 
        195                 200                 205             


Leu Gln Ser Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg Asn Val Gln 
    210                 215                 220                 


Asp Leu Val Glu Asp Phe Lys Asn Lys Tyr Glu Asp Glu Ile Asn Lys 
225                 230                 235                 240 


His Thr Ala Ala Glu Asn Glu Phe Val Val Leu Lys Lys Asp Val Asp 
                245                 250                 255     


Ala Ala Tyr Met Gly Arg Met Asp Leu His Gly Lys Val Gly Thr Leu 
            260                 265                 270         


Thr Gln Glu Ile Asp Phe Leu Gln Gln Leu Tyr Glu Met Glu Leu Ser 
        275                 280                 285             


Gln Val Gln Thr His Val Ser Asn Thr Asn Val Val Leu Ser Met Asp 
    290                 295                 300                 


Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu Val Lys Ala 
305                 310                 315                 320 


Gln Tyr Glu Leu Ile Ala Gln Arg Ser Arg Ala Glu Ala Glu Ala Trp 
                325                 330                 335     


Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Val Thr Ala Gly Lys His Gly 
            340                 345                 350         


Asp Asn Leu Arg Asp Thr Lys Asn Glu Ile Ala Glu Leu Thr Arg Thr 
        355                 360                 365             


Ile Gln Arg Leu Gln Gly Glu Ala Asp Ala Ala Lys Lys Gln Cys Gln 
    370                 375                 380                 


Gln Leu Gln Thr Ala Ile Ala Glu Ala Glu Gln Arg Gly Glu Leu Ala 
385                 390                 395                 400 


Leu Lys Asp Ala Gln Lys Lys Leu Gly Asp Leu Asp Val Ala Leu His 
                405                 410                 415     


Gln Ala Lys Glu Asp Leu Thr Arg Leu Leu Arg Asp Tyr Gln Glu Leu 
            420                 425                 430         


Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr Tyr Arg Lys 
        435                 440                 445             


Leu Leu Glu Ser Glu Glu Ser Arg Met Ser Gly Glu Cys Pro Ser Ala 
    450                 455                 460                 


Val Ser Ile Ser Val Thr Gly Asn Ser Thr Thr Val Cys Gly Gly Gly 
465                 470                 475                 480 


Ala Ala Ser Phe Gly Gly Gly Ile Ser Leu Gly Gly Ser Gly Gly Ala 
                485                 490                 495     


Thr Lys Gly Gly Phe Ser Thr Asn Val Gly Tyr Ser Thr Val Lys Gly 
            500                 505                 510         


Gly Pro Val Ser Ala Gly Thr Ser Ile Leu Arg Lys Thr Thr Thr Val 
        515                 520                 525             


Lys Thr Ser Ser Gln Arg Tyr 
    530                 535 


<210>  649
<211>  3615
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (149)..(2077)

<400>  649
acttccggtc tccggggtcg acgacatagc gggtcgtatt tttatccaaa agaaggacct       60

ggaggaggat gagagcgtta ctgctgcaca cctaaagtca agggggagaa gcccgaggaa      120

gattgaccag ttttgtaatt ctagcaac atg gtc cat gga tca gtg aca ttc         172
                               Met Val His Gly Ser Val Thr Phe            
                               1               5                          

agg gat gtg gcc att gac ttc tct cag gag gag tgg gag tgc ctg cag        220
Arg Asp Val Ala Ile Asp Phe Ser Gln Glu Glu Trp Glu Cys Leu Gln           
    10                  15                  20                            

cct gat cag agg acc ttg tac agg gat gtg atg ttg gag aac tac agc        268
Pro Asp Gln Arg Thr Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser           
25                  30                  35                  40            

cac ctg atc tca ctg gca gga agt tcc att tct aaa cca gat gta att        316
His Leu Ile Ser Leu Ala Gly Ser Ser Ile Ser Lys Pro Asp Val Ile           
                45                  50                  55                

acg tta cta gag caa gag aaa gag ccc tgg atg gtt gta agg aaa gaa        364
Thr Leu Leu Glu Gln Glu Lys Glu Pro Trp Met Val Val Arg Lys Glu           
            60                  65                  70                    

aca agc aga cgg tat cca gat ttg gag tta aaa tat gga cct gag aaa        412
Thr Ser Arg Arg Tyr Pro Asp Leu Glu Leu Lys Tyr Gly Pro Glu Lys           
        75                  80                  85                        

gta tct cca gaa aat gat acc tct gaa gta aat tta ccc aaa cag gtt        460
Val Ser Pro Glu Asn Asp Thr Ser Glu Val Asn Leu Pro Lys Gln Val           
    90                  95                  100                           

ata aag caa ata agt aca act ctt ggc att gag gcc ttt tat ttt aga        508
Ile Lys Gln Ile Ser Thr Thr Leu Gly Ile Glu Ala Phe Tyr Phe Arg           
105                 110                 115                 120           

aat gac tca gaa tat aga caa ttt gag gga cta cag gga tat caa gaa        556
Asn Asp Ser Glu Tyr Arg Gln Phe Glu Gly Leu Gln Gly Tyr Gln Glu           
                125                 130                 135               

gga aat atc aat caa aag atg atc agc tat gaa aaa ctg cct act cat        604
Gly Asn Ile Asn Gln Lys Met Ile Ser Tyr Glu Lys Leu Pro Thr His           
            140                 145                 150                   

act cct cat gct tct ctt att tgc aat aca cat aaa ccg tat gaa tgt        652
Thr Pro His Ala Ser Leu Ile Cys Asn Thr His Lys Pro Tyr Glu Cys           
        155                 160                 165                       

aag gaa tgt ggg aaa tac ttt agt cgt agt gca aat ctt att cag cat        700
Lys Glu Cys Gly Lys Tyr Phe Ser Arg Ser Ala Asn Leu Ile Gln His           
    170                 175                 180                           

cag agt att cat act gga gag aaa ccc ttt gaa tgt aag gag tgt ggg        748
Gln Ser Ile His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly           
185                 190                 195                 200           

aaa gcc ttt cga ctt cac ata caa ttt act cga cat cag aaa ttt cat        796
Lys Ala Phe Arg Leu His Ile Gln Phe Thr Arg His Gln Lys Phe His           
                205                 210                 215               

act ggt gag aaa cct ttt gaa tgt aac gaa tgt gga aag gcc ttt agt        844
Thr Gly Glu Lys Pro Phe Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser           
            220                 225                 230                   

ctt ctt acc ctg ctt aat cgc cat aag aac att cac aca ggt gag aaa        892
Leu Leu Thr Leu Leu Asn Arg His Lys Asn Ile His Thr Gly Glu Lys           
        235                 240                 245                       

ctg ttt gaa tgt aag gaa tgt ggg aag tcc ttt aat cgt agc tca aac        940
Leu Phe Glu Cys Lys Glu Cys Gly Lys Ser Phe Asn Arg Ser Ser Asn           
    250                 255                 260                           

ctt gtt caa cat cag agt att cat tct ggt gta aaa cca tat gaa tgt        988
Leu Val Gln His Gln Ser Ile His Ser Gly Val Lys Pro Tyr Glu Cys           
265                 270                 275                 280           

aag gag tgt ggg aaa ggc ttt aat cgt ggt gca cac ctt att cag cat       1036
Lys Glu Cys Gly Lys Gly Phe Asn Arg Gly Ala His Leu Ile Gln His           
                285                 290                 295               

cag aaa att cat tcc aat gag aaa ccc ttt gta tgt aag gaa tgt ggg       1084
Gln Lys Ile His Ser Asn Glu Lys Pro Phe Val Cys Lys Glu Cys Gly           
            300                 305                 310                   

atg gcc ttt cga tat cat tac caa ctt att gaa cat tgc caa att cat       1132
Met Ala Phe Arg Tyr His Tyr Gln Leu Ile Glu His Cys Gln Ile His           
        315                 320                 325                       

act ggt gag aaa ccc ttt gaa tgt aaa gaa tgt gga aag gcg ttt act       1180
Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Ala Phe Thr           
    330                 335                 340                           

ctt ctg aca aag ctt gtt cga cat cag aag att cat act ggt gag aaa       1228
Leu Leu Thr Lys Leu Val Arg His Gln Lys Ile His Thr Gly Glu Lys           
345                 350                 355                 360           

ccc ttt gaa tgc agg gaa tgt ggg aag gcc ttt agt ctt ctc aac cag       1276
Pro Phe Glu Cys Arg Glu Cys Gly Lys Ala Phe Ser Leu Leu Asn Gln           
                365                 370                 375               

ctt aat cgc cat aag aac att cac aca ggt gaa aaa ccg ttt gaa tgt       1324
Leu Asn Arg His Lys Asn Ile His Thr Gly Glu Lys Pro Phe Glu Cys           
            380                 385                 390                   

aag gaa tgt ggg aag tcc ttt aat cgt agc tca aac ctt gtt caa cat       1372
Lys Glu Cys Gly Lys Ser Phe Asn Arg Ser Ser Asn Leu Val Gln His           
        395                 400                 405                       

cag agt att cat gct ggt ata aaa cca tat gaa tgt aag gag tgt ggg       1420
Gln Ser Ile His Ala Gly Ile Lys Pro Tyr Glu Cys Lys Glu Cys Gly           
    410                 415                 420                           

aaa ggc ttt aat cgt ggt gca cac ctt att cag cat cag aaa att cat       1468
Lys Gly Phe Asn Arg Gly Ala His Leu Ile Gln His Gln Lys Ile His           
425                 430                 435                 440           

tcc aat gag aaa cct ttt gta tgt agg gaa tgt gag atg gcc ttt aga       1516
Ser Asn Glu Lys Pro Phe Val Cys Arg Glu Cys Glu Met Ala Phe Arg           
                445                 450                 455               

tat cat tgc caa ctt att gaa cat tct cga att cat act ggt gac aag       1564
Tyr His Cys Gln Leu Ile Glu His Ser Arg Ile His Thr Gly Asp Lys           
            460                 465                 470                   

cca ttt gaa tgt caa gac tgt ggg aag gcc ttc aat cgt ggc tca agc       1612
Pro Phe Glu Cys Gln Asp Cys Gly Lys Ala Phe Asn Arg Gly Ser Ser           
        475                 480                 485                       

ctt gtt caa cat cag agt att cac act ggt gag aag ccc tat gaa tgt       1660
Leu Val Gln His Gln Ser Ile His Thr Gly Glu Lys Pro Tyr Glu Cys           
    490                 495                 500                           

aag gag tgt ggg aag gct ttt aga ctt tac cta caa ctt tcc caa cat       1708
Lys Glu Cys Gly Lys Ala Phe Arg Leu Tyr Leu Gln Leu Ser Gln His           
505                 510                 515                 520           

cag aaa act cac aca ggt gaa aaa cca ttt gaa tgt aag gaa tgt ggg       1756
Gln Lys Thr His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly           
                525                 530                 535               

aaa ttc ttt cgt cgt ggt tca aat ctt aat caa cat cga agt att cat       1804
Lys Phe Phe Arg Arg Gly Ser Asn Leu Asn Gln His Arg Ser Ile His           
            540                 545                 550                   

act gga aag aaa ccc ttt gaa tgt aag gaa tgt ggg aaa gcc ttt cga       1852
Thr Gly Lys Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Ala Phe Arg           
        555                 560                 565                       

ctt cat atg cac ctt att cga cat cag aaa ttg cat act ggt gag aaa       1900
Leu His Met His Leu Ile Arg His Gln Lys Leu His Thr Gly Glu Lys           
    570                 575                 580                           

ccc ttt gaa tgt aag gag tgt ggg aaa gcc ttt cga ctt cat atg caa       1948
Pro Phe Glu Cys Lys Glu Cys Gly Lys Ala Phe Arg Leu His Met Gln           
585                 590                 595                 600           

ctt att cga cat cag aaa ttg cat act ggt gag aaa ccc ttt gaa tgt       1996
Leu Ile Arg His Gln Lys Leu His Thr Gly Glu Lys Pro Phe Glu Cys           
                605                 610                 615               

aag gaa tgt gga aag gtt ttt agt ctt ccc acc cag ctt aat cgc cat       2044
Lys Glu Cys Gly Lys Val Phe Ser Leu Pro Thr Gln Leu Asn Arg His           
            620                 625                 630                   

aag aac att cac aca ggt gag aag gca tct tga atgtaaggaa tgtggaaagt     2097
Lys Asn Ile His Thr Gly Glu Lys Ala Ser                                   
        635                 640                                           

cctttaatcg tgtctcaaac catgttcaac atcagagtat tcgtgctggt gtaaaaccat     2157

gtgaatgtaa ggggtgtggg aaaggcttca tttgtggttc aaacgttatt cagcatcaga     2217

aaattcattc cagtgagaaa ctctttgtat gcaaggagtg gaggacgacc tttagatatc     2277

attaccactt atttaacatt accaaattca cactggtaaa aaaccctttg aatgtaaaga     2337

atgtggaaag gccttcagtt ttctgacaca gcttgctgga cttcaggtca ttcatactgg     2397

cgagaagcca tttgaatttg agaaatgtgg gaaggccttc aatagtggct caaaccttgt     2457

tcaacatcag agtattcata ctggtgagaa actctatgaa tgtaaggagt gtgggaaaac     2517

tttcagattt agtttggtcc tgactgcaca tcaaagaatt catactggta tgaaaccctg     2577

tgaatgtaca gaatgtggga agacctttag ttgtagctca aacattgttc aacatgttaa     2637

aattcatact ggtgagaaac gctataatgt aaggaatatg ggaaagcatt tgctgtggat     2697

gatcagctgt ctcaacatca gaaaattcag aatagttaga aattttgtga caataaggag     2757

tgtggacaag ccttcactgt gtacgaaaaa tttactcaac accagagagc tcatattgat     2817

gagaaatctt gtgaacataa aagaatgtgt gaagaacttt catcatggcc tgggatttgc     2877

tcaacttctg agtattcata cttctgagaa atctttgagt gtaaggaatg tggggcgttt     2937

tatagccaca ctaaatacct tagagttcgg agaagataat tcttgtgaga aagtctttga     2997

atgaggaata tagggtagtt gtcatgttca caatgtactc cctatgaaat aatttaccag     3057

atacaggcat acctcgctga attgtgcatt gcagttattg tgttttatac aaactgaagg     3117

tttgtggcaa ccctgtggtg agcaagacga tcaggtccat tttcccaacg tcaggtgtgc     3177

atttcatgtc tttatgtcac attttggtaa ttctcagaat atttcaaact atttcattgt     3237

tatatatcta tcatggtgat caatgaccag tgatttttga tgttgctatt gtaattgctt     3297

tgggatacca caaattctgc ccataaaaga tggtaaacct agttgatact tgttgtgggt     3357

tttgaaagaa tagtcaaata tacaatcata taccccaacc tagattcaaa attgttaaca     3417

atttgcacgt ttattttttg tatatttgtt gtaccattga gaataagttt tagacatcat     3477

gacactttac cctttattta atcaacgtgt gtatcaacca aacatgaaga caatatagac     3537

aatatcatat agccattgta ccataattac cgttaaggaa agtattcata attctgtaat     3597

atcaaaaaaa aaaaaaaa                                                   3615


<210>  650
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  650

Met Val His Gly Ser Val Thr Phe Arg Asp Val Ala Ile Asp Phe Ser 
1               5                   10                  15      


Gln Glu Glu Trp Glu Cys Leu Gln Pro Asp Gln Arg Thr Leu Tyr Arg 
            20                  25                  30          


Asp Val Met Leu Glu Asn Tyr Ser His Leu Ile Ser Leu Ala Gly Ser 
        35                  40                  45              


Ser Ile Ser Lys Pro Asp Val Ile Thr Leu Leu Glu Gln Glu Lys Glu 
    50                  55                  60                  


Pro Trp Met Val Val Arg Lys Glu Thr Ser Arg Arg Tyr Pro Asp Leu 
65                  70                  75                  80  


Glu Leu Lys Tyr Gly Pro Glu Lys Val Ser Pro Glu Asn Asp Thr Ser 
                85                  90                  95      


Glu Val Asn Leu Pro Lys Gln Val Ile Lys Gln Ile Ser Thr Thr Leu 
            100                 105                 110         


Gly Ile Glu Ala Phe Tyr Phe Arg Asn Asp Ser Glu Tyr Arg Gln Phe 
        115                 120                 125             


Glu Gly Leu Gln Gly Tyr Gln Glu Gly Asn Ile Asn Gln Lys Met Ile 
    130                 135                 140                 


Ser Tyr Glu Lys Leu Pro Thr His Thr Pro His Ala Ser Leu Ile Cys 
145                 150                 155                 160 


Asn Thr His Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Tyr Phe Ser 
                165                 170                 175     


Arg Ser Ala Asn Leu Ile Gln His Gln Ser Ile His Thr Gly Glu Lys 
            180                 185                 190         


Pro Phe Glu Cys Lys Glu Cys Gly Lys Ala Phe Arg Leu His Ile Gln 
        195                 200                 205             


Phe Thr Arg His Gln Lys Phe His Thr Gly Glu Lys Pro Phe Glu Cys 
    210                 215                 220                 


Asn Glu Cys Gly Lys Ala Phe Ser Leu Leu Thr Leu Leu Asn Arg His 
225                 230                 235                 240 


Lys Asn Ile His Thr Gly Glu Lys Leu Phe Glu Cys Lys Glu Cys Gly 
                245                 250                 255     


Lys Ser Phe Asn Arg Ser Ser Asn Leu Val Gln His Gln Ser Ile His 
            260                 265                 270         


Ser Gly Val Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Gly Phe Asn 
        275                 280                 285             


Arg Gly Ala His Leu Ile Gln His Gln Lys Ile His Ser Asn Glu Lys 
    290                 295                 300                 


Pro Phe Val Cys Lys Glu Cys Gly Met Ala Phe Arg Tyr His Tyr Gln 
305                 310                 315                 320 


Leu Ile Glu His Cys Gln Ile His Thr Gly Glu Lys Pro Phe Glu Cys 
                325                 330                 335     


Lys Glu Cys Gly Lys Ala Phe Thr Leu Leu Thr Lys Leu Val Arg His 
            340                 345                 350         


Gln Lys Ile His Thr Gly Glu Lys Pro Phe Glu Cys Arg Glu Cys Gly 
        355                 360                 365             


Lys Ala Phe Ser Leu Leu Asn Gln Leu Asn Arg His Lys Asn Ile His 
    370                 375                 380                 


Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Ser Phe Asn 
385                 390                 395                 400 


Arg Ser Ser Asn Leu Val Gln His Gln Ser Ile His Ala Gly Ile Lys 
                405                 410                 415     


Pro Tyr Glu Cys Lys Glu Cys Gly Lys Gly Phe Asn Arg Gly Ala His 
            420                 425                 430         


Leu Ile Gln His Gln Lys Ile His Ser Asn Glu Lys Pro Phe Val Cys 
        435                 440                 445             


Arg Glu Cys Glu Met Ala Phe Arg Tyr His Cys Gln Leu Ile Glu His 
    450                 455                 460                 


Ser Arg Ile His Thr Gly Asp Lys Pro Phe Glu Cys Gln Asp Cys Gly 
465                 470                 475                 480 


Lys Ala Phe Asn Arg Gly Ser Ser Leu Val Gln His Gln Ser Ile His 
                485                 490                 495     


Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Arg 
            500                 505                 510         


Leu Tyr Leu Gln Leu Ser Gln His Gln Lys Thr His Thr Gly Glu Lys 
        515                 520                 525             


Pro Phe Glu Cys Lys Glu Cys Gly Lys Phe Phe Arg Arg Gly Ser Asn 
    530                 535                 540                 


Leu Asn Gln His Arg Ser Ile His Thr Gly Lys Lys Pro Phe Glu Cys 
545                 550                 555                 560 


Lys Glu Cys Gly Lys Ala Phe Arg Leu His Met His Leu Ile Arg His 
                565                 570                 575     


Gln Lys Leu His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly 
            580                 585                 590         


Lys Ala Phe Arg Leu His Met Gln Leu Ile Arg His Gln Lys Leu His 
        595                 600                 605             


Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Val Phe Ser 
    610                 615                 620                 


Leu Pro Thr Gln Leu Asn Arg His Lys Asn Ile His Thr Gly Glu Lys 
625                 630                 635                 640 


Ala Ser 
        


<210>  651
<211>  2121
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (542)..(1321)

<400>  651
ccaataggca gagccctagg acctgcccac gtctggttca ggggctagaa aagagcgtcg       60

atgccggcgg cagtgatgag tcctaggagg cgctggctct ttggcggctc ggaggagcgg      120

ctgctgctgc tgctgctgct gctggtggcc cctttgcaga aaagttctaa gaacagtgct      180

gttggctcag tgagatgagg ttatcggaaa actttctgtt tacacaagag ttgcctcctt      240

caaagaagca tgcatggtcc ttgcaggtca ctgtgcccat cactctgcat agtccagctg      300

cactctgctt cacacagctg cctgcccatt gcaggcattt gagtttgcaa tccatgcctt      360

aaactttaaa tcacactggc tacagcgttg tgtgtttctt ggtaaacact gggtaaatca      420

gctcctgtgg atgttgactg aagtttctat gtttgcaagc taatcctcag cagtttcttt      480

atgtattgct gtccttgaat attagcccat ttgaaaacgc ctgggaagtt cagccatcag      540

t atg tcc aag tac aaa ctt att atg tta aga cat gga gag ggt gct tgg      589
  Met Ser Lys Tyr Lys Leu Ile Met Leu Arg His Gly Glu Gly Ala Trp         
  1               5                   10                  15              

aat aag gag aac cgt ttt tgt agc tgg gtg gat cag aaa ctc aac agc        637
Asn Lys Glu Asn Arg Phe Cys Ser Trp Val Asp Gln Lys Leu Asn Ser           
            20                  25                  30                    

gaa gga atg gag gaa gct cgg aac tgt ggg aag caa ctc aaa gcg tta        685
Glu Gly Met Glu Glu Ala Arg Asn Cys Gly Lys Gln Leu Lys Ala Leu           
        35                  40                  45                        

aac ttt gag ttt gat ctt gta ttc aca tct gtc ctt aat cgg tcc att        733
Asn Phe Glu Phe Asp Leu Val Phe Thr Ser Val Leu Asn Arg Ser Ile           
    50                  55                  60                            

cac aca gcc tgg ctg atc ctg gaa gag cta ggc cag gaa tgg gtg cct        781
His Thr Ala Trp Leu Ile Leu Glu Glu Leu Gly Gln Glu Trp Val Pro           
65                  70                  75                  80            

gtg gaa agc tcc tgg cgt cta aat gag cgt cac tat ggg gcc ttg atc        829
Val Glu Ser Ser Trp Arg Leu Asn Glu Arg His Tyr Gly Ala Leu Ile           
                85                  90                  95                

ggt ctc aac agg gag cag atg gct ttg aat cat ggt gaa gaa caa gtg        877
Gly Leu Asn Arg Glu Gln Met Ala Leu Asn His Gly Glu Glu Gln Val           
            100                 105                 110                   

agg ctc tgg aga aga agc tac aat gta acc ccg cct ccc att gag gag        925
Arg Leu Trp Arg Arg Ser Tyr Asn Val Thr Pro Pro Pro Ile Glu Glu           
        115                 120                 125                       

tct cat cct tac tac caa gaa atc tac aac gac cgg agg tat aaa gta        973
Ser His Pro Tyr Tyr Gln Glu Ile Tyr Asn Asp Arg Arg Tyr Lys Val           
    130                 135                 140                           

tgc gat gtg ccc ttg gat caa ctg cca cgg tcg gaa agc tta aag gat       1021
Cys Asp Val Pro Leu Asp Gln Leu Pro Arg Ser Glu Ser Leu Lys Asp           
145                 150                 155                 160           

gtt ctg gag aga ctc ctt ccc tat tgg aat gaa agg att gct ccc gaa       1069
Val Leu Glu Arg Leu Leu Pro Tyr Trp Asn Glu Arg Ile Ala Pro Glu           
                165                 170                 175               

gta tta cgt ggc aaa acc att ctg ata tct gct cat gga aat agc agt       1117
Val Leu Arg Gly Lys Thr Ile Leu Ile Ser Ala His Gly Asn Ser Ser           
            180                 185                 190                   

agg gca ctc cta aaa cac ctg gaa ggt atc tca gat gaa gac atc atc       1165
Arg Ala Leu Leu Lys His Leu Glu Gly Ile Ser Asp Glu Asp Ile Ile           
        195                 200                 205                       

aac att act ctt cct act gga gtc ccc att ctt ctg gaa ttg gat gaa       1213
Asn Ile Thr Leu Pro Thr Gly Val Pro Ile Leu Leu Glu Leu Asp Glu           
    210                 215                 220                           

aac ctg cgt gct gtt ggg cct cat cag ttc ctg ggt gac caa gag gcg       1261
Asn Leu Arg Ala Val Gly Pro His Gln Phe Leu Gly Asp Gln Glu Ala           
225                 230                 235                 240           

atc caa gca gcc att aag aaa gta gaa gat caa gga aaa gtg aaa caa       1309
Ile Gln Ala Ala Ile Lys Lys Val Glu Asp Gln Gly Lys Val Lys Gln           
                245                 250                 255               

gct aaa aaa tag tctttctcaa ctgttggcta agaagaaatg caaaagaagt           1361
Ala Lys Lys                                                               
                                                                          

ggcataggag tgtgttatgg gtgctgaact ctctctcttt ttccccgatt ttccagagct     1421

aggctgtgga gtagagtttg tataggtaac taggtaactt attgtggccc agataaggct     1481

ttaggatgcc tcagtgctta tgtcatagcc ttatgagtta gctttcttgc tagcccccta     1541

gtcggtcacc aaactagtaa ctagtggggc ttaatgaagg tcataagttt ctgagatggg     1601

agagcaacaa gtagagatga agttaaaggt atttatcatt caagaaatca ttattgagtc     1661

accattgaca ggcactattc taatcagtag ttcactttaa tatttaataa gattttctgg     1721

gataacagta agggatatta gataatatac cgtatgtatt tattactagt cttttcctct     1781

aggaaaaggg atactttgat aattaaggcc agaggcccat tagttgagaa agtcacagat     1841

atatttctcc aagaaagcca acaaccacca ccacaatgac agaaatgaca acaaggccct     1901

ttaacttgtc ttctagttta gagacatcct tcatttgaca tttagtagaa ttcctctttg     1961

gccacaagaa taagcagcaa ataaacaact atggctgttg aggttctcat tttggtttgt     2021

tttaattttt tgaactttgg gtacctgtaa ttagtttaaa aataaagttc ctgataataa     2081

agtgactgaa aatggcatcc ccaaaaaaaa aaaaaaaaaa                           2121


<210>  652
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  652

Met Ser Lys Tyr Lys Leu Ile Met Leu Arg His Gly Glu Gly Ala Trp 
1               5                   10                  15      


Asn Lys Glu Asn Arg Phe Cys Ser Trp Val Asp Gln Lys Leu Asn Ser 
            20                  25                  30          


Glu Gly Met Glu Glu Ala Arg Asn Cys Gly Lys Gln Leu Lys Ala Leu 
        35                  40                  45              


Asn Phe Glu Phe Asp Leu Val Phe Thr Ser Val Leu Asn Arg Ser Ile 
    50                  55                  60                  


His Thr Ala Trp Leu Ile Leu Glu Glu Leu Gly Gln Glu Trp Val Pro 
65                  70                  75                  80  


Val Glu Ser Ser Trp Arg Leu Asn Glu Arg His Tyr Gly Ala Leu Ile 
                85                  90                  95      


Gly Leu Asn Arg Glu Gln Met Ala Leu Asn His Gly Glu Glu Gln Val 
            100                 105                 110         


Arg Leu Trp Arg Arg Ser Tyr Asn Val Thr Pro Pro Pro Ile Glu Glu 
        115                 120                 125             


Ser His Pro Tyr Tyr Gln Glu Ile Tyr Asn Asp Arg Arg Tyr Lys Val 
    130                 135                 140                 


Cys Asp Val Pro Leu Asp Gln Leu Pro Arg Ser Glu Ser Leu Lys Asp 
145                 150                 155                 160 


Val Leu Glu Arg Leu Leu Pro Tyr Trp Asn Glu Arg Ile Ala Pro Glu 
                165                 170                 175     


Val Leu Arg Gly Lys Thr Ile Leu Ile Ser Ala His Gly Asn Ser Ser 
            180                 185                 190         


Arg Ala Leu Leu Lys His Leu Glu Gly Ile Ser Asp Glu Asp Ile Ile 
        195                 200                 205             


Asn Ile Thr Leu Pro Thr Gly Val Pro Ile Leu Leu Glu Leu Asp Glu 
    210                 215                 220                 


Asn Leu Arg Ala Val Gly Pro His Gln Phe Leu Gly Asp Gln Glu Ala 
225                 230                 235                 240 


Ile Gln Ala Ala Ile Lys Lys Val Glu Asp Gln Gly Lys Val Lys Gln 
                245                 250                 255     


Ala Lys Lys 
            


<210>  653
<211>  4490
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (375)..(989)

<400>  653
cccgcagtcg cgcaagcgcg agcggctgtg cgcggtgcgt ggtgcgtggt gcgtgatacg       60

agcggcggca cgtggcgcgg gtgcggggcg tggagtggcg tggcgtggag tggcgtggcg      120

tggcggggtc tcgcggcgcg ggcgcgcacc cggagctgtg gacggagagt gcctccctct      180

ggcctcagtt tcctcatgtt gtagtagcgg agcatggccc ggaccgggcc cccgagaccg      240

ccccgtgcaa cctcaccgcc agcctggggg cctcagcgac tgggacggga ccaaggggct      300

cggggattct ccctgccccc ggccctggtg cgtgactgac cctcctgttc ccagagcccc      360

cagcgcaggc cggg atg ttc gtc ctg gtg gaa atg gtg gac acc gtc cgg        410
                Met Phe Val Leu Val Glu Met Val Asp Thr Val Arg           
                1               5                   10                    

atc ccc cct tgg cag ttt gag agg aag ctc aac gac tcc att gcc gag        458
Ile Pro Pro Trp Gln Phe Glu Arg Lys Leu Asn Asp Ser Ile Ala Glu           
        15                  20                  25                        

gag ctg aac aag aag ttg gcc aac aag gtc gtg tac aac gtg gga ctc        506
Glu Leu Asn Lys Lys Leu Ala Asn Lys Val Val Tyr Asn Val Gly Leu           
    30                  35                  40                            

tgc att tgt ctg ttt gat atc acc aaa ctg gag gat gcc tat gta ttc        554
Cys Ile Cys Leu Phe Asp Ile Thr Lys Leu Glu Asp Ala Tyr Val Phe           
45                  50                  55                  60            

cct ggg gat ggc gca tca cac acc aaa gtc cat ttt cgc tgc gtg gtg        602
Pro Gly Asp Gly Ala Ser His Thr Lys Val His Phe Arg Cys Val Val           
                65                  70                  75                

ttt cat cca ttc cta gat gag att ctc att ggg aag atc aaa ggc tgc        650
Phe His Pro Phe Leu Asp Glu Ile Leu Ile Gly Lys Ile Lys Gly Cys           
            80                  85                  90                    

agc cca gaa gga gtg cac gtc tct cta ggc ttc ttc gat gac att ctc        698
Ser Pro Glu Gly Val His Val Ser Leu Gly Phe Phe Asp Asp Ile Leu           
        95                  100                 105                       

atc ccc cca gag tca ctg cag cag cca gcc aag ttc gac gaa gcg gag        746
Ile Pro Pro Glu Ser Leu Gln Gln Pro Ala Lys Phe Asp Glu Ala Glu           
    110                 115                 120                           

cag gtg tgg gtg tgg gag tac gag acg gag gaa gga gca cac gac ctc        794
Gln Val Trp Val Trp Glu Tyr Glu Thr Glu Glu Gly Ala His Asp Leu           
125                 130                 135                 140           

tac atg gac acc ggc gag gag atc cgc ttc cgg gtg gtg gac gag agc        842
Tyr Met Asp Thr Gly Glu Glu Ile Arg Phe Arg Val Val Asp Glu Ser           
                145                 150                 155               

ttt gtt gac acg tcc ccc aca ggg ccc agc tca gca gat gcc acc act        890
Phe Val Asp Thr Ser Pro Thr Gly Pro Ser Ser Ala Asp Ala Thr Thr           
            160                 165                 170                   

tcc agt gag gag ctg cca aag aag gag gct ccg tac acg ctt gtg gga        938
Ser Ser Glu Glu Leu Pro Lys Lys Glu Ala Pro Tyr Thr Leu Val Gly           
        175                 180                 185                       

tcc atc agt gag cca ggc ctg ggc ctt ctc tcc tgg tgg acc agc aac        986
Ser Ile Ser Glu Pro Gly Leu Gly Leu Leu Ser Trp Trp Thr Ser Asn           
    190                 195                 200                           

tag ccctggggct ggacagtgga ccctaccagc ctgcgggaag gtggtatggc            1039

cggctgtgaa gacaacagca gctgaggccg atgctaagga gatagtgtct cgagctggac     1099

agtgaggcaa ggccaggagt gcccaccagc ttgccccgct cctccaccat ctaggccctg     1159

ctcctccttc actgcagtga tggatccatc tgtggctgtg gctgttgggc ctccactgac     1219

cttgactgaa aagacccttc ctggaccctg gacttgacaa caaacggcac agacaccaat     1279

cactcacaga acagtcactg gttttggatt cttgttttcc ttgcaagaac aaaaggttct     1339

ctagaatcct tcagccacca atgaaatgat caggcaggag aaaaacttta gatgggagtc     1399

ttgtcatcaa aaataaatac agttgcatgg agctgcttaa gatctgaacc aaactcaaaa     1459

taggaagacg ggggctaaaa agttatttta agaacccccc caccacaacc acagtcactc     1519

cgtgggctaa gcggggagca ggaagcatgt ctggtcacac catcttggaa taggaagcca     1579

tggctggacg gatcggatcc actgatggca cacgtggagc tgaacttgac gccagcggcg     1639

gggcggggag gcactgccct cactgttgca gttccttcat tctgttgagg gcactgccag     1699

cgcggaacca ctcaatctgc gtctcgttga aggtgtggtt caggaggatg gtctcctggg     1759

tcccgttggg gtgcttgatg atgcacttca ggggctgcaa ggagaaggtg ggtgtgggtg     1819

gaagtggtgg gtactgtgtg cccttggccc cgcagggggg tcagggagac agggcactgc     1879

ctggggacct aagaggtcag caggcaaacc aaatcctagg ccagtctgtg cctgatggcc     1939

caggtcagac ccaggtggca cctacagggg attcctgggg cccagagggt cctgcagtgg     1999

gtgggctgtc ccctgagtgc caggtcctgg tgagtaaagg gaggttgggg aggtgtgagg     2059

gccccgggtt gactccaacc cccaactctg agaagccact ttgctttctc tgtggggcca     2119

cctggagaac tgggggcctt tccagctgga atgaagcctc ctgggagaag ctaccctggg     2179

gccagtgcag gaggggaaac aaggtggctg cccctcaccc caccacctca gggggacccg     2239

ggcccctaac cttgccaggg gtgaagtcct tcaggccctg aatggtcagc ttgtccacag     2299

ggtgaatctt gttgtagtca gccgggtcag cgaaggtcag aggcagcagg ccctgtttct     2359

tcaggttggt ctctggaaag caggcggcat tcggtcatcg ggggcctgac tagcctggag     2419

agcttcattt tctgaaccca tctggggctc tgggagatgc ccctaatcct gctgcctggg     2479

acaatgcccg ggcagtgact atggggccct ggtctgctcc ctttcactag gggtgcccct     2539

agcaagtgtg cgctggtgct gaggtctgcg aggccttcct gctgcacatt catgatcaga     2599

aagaaccccc tggcacatgt cctagatctc agcggctcag atctacaagc ctggaagcag     2659

ggcctgcggg aagccgggaa gctgagcgtc ggatgtgcac tgtgtgagcc taagaagggg     2719

caagaggctg acgggcctgt gggctgcagt ggacacagcc tagaaccagg cccaactcag     2779

ccacgggcag ggagagtgac cttgatcact agggatggga tgaggatggc ctgggtacag     2839

actccagctc accgtggatc ctggcaaagc tcttggtgat gatggcccgg cccccaaggt     2899

ggcgaggctc cagagctgca tgctcccggc tcgagccctc gccgtagttc tcgtctccga     2959

tcaccaccca cctgatgcca tgtttctgtc aggcaagcgg gggtaaggtt ataaggcaga     3019

ggagggcacc gtcctcacct gtctggccct acctgcctgg cctcacccac ctggcgcctg     3079

ggcatcctga ggctcccggt aaaggggctg gaggggccct tcctcgcctg ctgcctaagg     3139

gcaagtgaag cctgcgtgaa tgagacccaa acgaggcccc gaggggacag aggcacgtgg     3199

ttgtttgcag tggcaaagaa gacagaagcc acccattggt gcttggcaga ggcaggtgtg     3259

tgtggaggga ggttgggtga gacagggacg gcctccgggc cccacacaag atgcatctgt     3319

gaagctcaag gcgccccctt cctgggagca ccctctgccc cacccagcca ccagggggtg     3379

ccagagtcct ttcacccggc tgggccagga cttgggttca gccctggttc tgtttgtttc     3439

tcaaagcaga aaaagtccaa tcacctcaga ccctctctgc ctgctcactg tgaggccccg     3499

tgtagccccc tctctgagct tttggcctct gacttcctga gtcggccccc ttccttgtct     3559

ttgtctaggg ccagatatcc taagatatct ctcactaact cctcctggtg cagggacccg     3619

gctgtaccac cggacctggg cctcatgcct tctcagccac agggaggggc tgcaggcctc     3679

tcctcccttc cacagcagtc ccctttgggc ttggtcggcc tccttcccag tttccactcc     3739

cctaatgtcc tccctgcacc tgccttgcag gccccttcag gagtgaccac tggcattgcc     3799

cctatcaact ctgacccacc ttgtagtagc gggcagtgtc agggacgggg ccaaactcct     3859

gagtgacggc attgcgcacg gagttggcct tgccgttttc aatgttgatg gcaccaatga     3919

gcaggttgtt ggagatgtta tccaagtgcc cacggaactt gagccagggg ccagcagctg     3979

agatgtggtc agtggtacac ttccctttga ccttgggtgg taagtagaga ggacagaggt     4039

cagggcatgg ccctggaggg gtggatgaca agccctccag aggcaggcag caggccccgg     4099

ggcccaggag gggtgacaga ggggtgagag gcaggcaagt cttcagacac gtgttctgtg     4159

gtcctggtgc ttccacccta aggccacatg ggctcaggcc aggccttcat cccctcaaag     4219

gcctctggct gctcagtctc ccttatgggg cagaggccgc ccaaagttgg gacaggtcaa     4279

tgttcgctca cccttcaggc ctcagctgca agatcagcca cagacctcat gctggacaca     4339

ggagcccagg acatgcctgg gtcctggctg atgactgatt agtctcttct gtcacagggg     4399

tgcctggaga ccccttaata agcagcataa ataaatatct gacacagatt ggaggcctct     4459

ggccacacca aaaaaaaaaa aaaaaaaaaa a                                    4490


<210>  654
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  654

Met Phe Val Leu Val Glu Met Val Asp Thr Val Arg Ile Pro Pro Trp 
1               5                   10                  15      


Gln Phe Glu Arg Lys Leu Asn Asp Ser Ile Ala Glu Glu Leu Asn Lys 
            20                  25                  30          


Lys Leu Ala Asn Lys Val Val Tyr Asn Val Gly Leu Cys Ile Cys Leu 
        35                  40                  45              


Phe Asp Ile Thr Lys Leu Glu Asp Ala Tyr Val Phe Pro Gly Asp Gly 
    50                  55                  60                  


Ala Ser His Thr Lys Val His Phe Arg Cys Val Val Phe His Pro Phe 
65                  70                  75                  80  


Leu Asp Glu Ile Leu Ile Gly Lys Ile Lys Gly Cys Ser Pro Glu Gly 
                85                  90                  95      


Val His Val Ser Leu Gly Phe Phe Asp Asp Ile Leu Ile Pro Pro Glu 
            100                 105                 110         


Ser Leu Gln Gln Pro Ala Lys Phe Asp Glu Ala Glu Gln Val Trp Val 
        115                 120                 125             


Trp Glu Tyr Glu Thr Glu Glu Gly Ala His Asp Leu Tyr Met Asp Thr 
    130                 135                 140                 


Gly Glu Glu Ile Arg Phe Arg Val Val Asp Glu Ser Phe Val Asp Thr 
145                 150                 155                 160 


Ser Pro Thr Gly Pro Ser Ser Ala Asp Ala Thr Thr Ser Ser Glu Glu 
                165                 170                 175     


Leu Pro Lys Lys Glu Ala Pro Tyr Thr Leu Val Gly Ser Ile Ser Glu 
            180                 185                 190         


Pro Gly Leu Gly Leu Leu Ser Trp Trp Thr Ser Asn 
        195                 200                 


<210>  655
<211>  960
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (631)..(960)

<400>  655
ggctgctcct ccatgttccg ccaccagggt gccatttccc tgatgatgag ccaagaggga       60

catgtgagga ggagggggcc gggaccatct gccttgccgc cccacccctt ctctgtggcc      120

atacccaggg gcttctcaaa acggtcacag cagcctccct taaagctggg catggggcgt      180

atggtgacct acacctgcaa gagcaagaag gcctggcgga gaggtgaagt cagttctgcc      240

catagcaagc caggaggtgt tgggcaacct gcctgagaag gaggggaagg agccagcagg      300

ggacgcctct gggaaaacag gggcctcaga cagcagccac tttatccaga tcctgcagtt      360

gaaggaagaa tacctgcaga gagccacagg gccccgtgag gtcagccctg agccctccac      420

cagggagaag gagtgtctgc ttgaaggcct ggaccacccc acttgctgcc agcctgtcag      480

tgaccaccac ccattcacag gagactgcgt gttggcctct tccagggtgg aggcaactcc      540

ttggaaccac ttccacagtt tggacaagga gcttcaaaac tcggccatgg ccaaggtttg      600

cccagcgagg agaaaagtga ggaagagaaa atg aag gaa gag gac agc tca ttc       654
                                 Met Lys Glu Glu Asp Ser Ser Phe          
                                 1               5                        

aag ctc tgt gtc cca ggc att gtt gcc ctc cag tcg cca ccg aac aag        702
Lys Leu Cys Val Pro Gly Ile Val Ala Leu Gln Ser Pro Pro Asn Lys           
    10                  15                  20                            

gct ttc aga tcc aca gac aca gtg ggt ttc ctg gag tcg gag ttg aag        750
Ala Phe Arg Ser Thr Asp Thr Val Gly Phe Leu Glu Ser Glu Leu Lys           
25                  30                  35                  40            

aag ctt ctg gga atg cag caa gag tcc cgc ctc tgg aag cta ggc agc        798
Lys Leu Leu Gly Met Gln Gln Glu Ser Arg Leu Trp Lys Leu Gly Ser           
                45                  50                  55                

caa gag ggc cga gag ctg ctt acc cgg cca gag atc acc gtg gtg gag        846
Gln Glu Gly Arg Glu Leu Leu Thr Arg Pro Glu Ile Thr Val Val Glu           
            60                  65                  70                    

gga gaa ggt tat gag gtg cag aga aga ctg agg cat ctt cct tca ccc        894
Gly Glu Gly Tyr Glu Val Gln Arg Arg Leu Arg His Leu Pro Ser Pro           
        75                  80                  85                        

att tct gtc gcc cag tgc ctg ctt ctt gag gag aaa ggt gag atg gga        942
Ile Ser Val Ala Gln Cys Leu Leu Leu Glu Glu Lys Gly Glu Met Gly           
    90                  95                  100                           

aac tgg cct cca gag tga                                                960
Asn Trp Pro Pro Glu                                                       
105                                                                       


<210>  656
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  656

Met Lys Glu Glu Asp Ser Ser Phe Lys Leu Cys Val Pro Gly Ile Val 
1               5                   10                  15      


Ala Leu Gln Ser Pro Pro Asn Lys Ala Phe Arg Ser Thr Asp Thr Val 
            20                  25                  30          


Gly Phe Leu Glu Ser Glu Leu Lys Lys Leu Leu Gly Met Gln Gln Glu 
        35                  40                  45              


Ser Arg Leu Trp Lys Leu Gly Ser Gln Glu Gly Arg Glu Leu Leu Thr 
    50                  55                  60                  


Arg Pro Glu Ile Thr Val Val Glu Gly Glu Gly Tyr Glu Val Gln Arg 
65                  70                  75                  80  


Arg Leu Arg His Leu Pro Ser Pro Ile Ser Val Ala Gln Cys Leu Leu 
                85                  90                  95      


Leu Glu Glu Lys Gly Glu Met Gly Asn Trp Pro Pro Glu 
            100                 105                 


<210>  657
<211>  3639
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (134)..(3505)

<400>  657
gcggcgctgg gtcggtggcg gaggctgagg agaaggagga gcgggccgtg gaggcttcgc       60

cgcctaggta ctgctataac cagaatttgg tagaaaaagg atttacttgt tggggccctc      120

ttgataaaaa gag atg tgg ggg gat tct cga cct gct aac aga act gga         169
               Met Trp Gly Asp Ser Arg Pro Ala Asn Arg Thr Gly            
               1               5                   10                     

cct ttt cgt ggg agc caa gaa gaa agg ttt gct ccc ggg tgg aac agg        217
Pro Phe Arg Gly Ser Gln Glu Glu Arg Phe Ala Pro Gly Trp Asn Arg           
        15                  20                  25                        

gat tat cct cct cct ccc ctt aag agt cat gct caa gag aga cac tct        265
Asp Tyr Pro Pro Pro Pro Leu Lys Ser His Ala Gln Glu Arg His Ser           
    30                  35                  40                            

ggc aac ttt cct ggc aga gat tca ctt ccc ttt gat ttc cag ggg cat        313
Gly Asn Phe Pro Gly Arg Asp Ser Leu Pro Phe Asp Phe Gln Gly His           
45                  50                  55                  60            

tcg ggg cct cct ttt gca aat gta gag gag cat tct ttc agc tat gga        361
Ser Gly Pro Pro Phe Ala Asn Val Glu Glu His Ser Phe Ser Tyr Gly           
                65                  70                  75                

gct aga gac gga ccg cat ggt gac tat cga gga ggg gag gga cct gga        409
Ala Arg Asp Gly Pro His Gly Asp Tyr Arg Gly Gly Glu Gly Pro Gly           
            80                  85                  90                    

cat gat ttc agg ggg gga gat ttt tcg tct tct gat ttc cag agc aga        457
His Asp Phe Arg Gly Gly Asp Phe Ser Ser Ser Asp Phe Gln Ser Arg           
        95                  100                 105                       

gat tca tca cag ttg gac ttc agg ggt agg gac ata cat tct ggg gat        505
Asp Ser Ser Gln Leu Asp Phe Arg Gly Arg Asp Ile His Ser Gly Asp           
    110                 115                 120                           

ttt cgg gat aga gaa gga cca cct atg gac tat agg ggt gga gat ggt        553
Phe Arg Asp Arg Glu Gly Pro Pro Met Asp Tyr Arg Gly Gly Asp Gly           
125                 130                 135                 140           

act tct atg gat tat aga ggt agg gag gca cct cat atg aac tac aga        601
Thr Ser Met Asp Tyr Arg Gly Arg Glu Ala Pro His Met Asn Tyr Arg           
                145                 150                 155               

gac agg gat gct cac gct gtt gac ttc aga ggt agg gat gct cct cca        649
Asp Arg Asp Ala His Ala Val Asp Phe Arg Gly Arg Asp Ala Pro Pro           
            160                 165                 170                   

tct gac ttc agg ggc cgg ggc act tat gat tta gat ttt aga ggc cgg        697
Ser Asp Phe Arg Gly Arg Gly Thr Tyr Asp Leu Asp Phe Arg Gly Arg           
        175                 180                 185                       

gat gga tcc cat gca gat ttt agg gga agg gat tta tca gat ttg gat        745
Asp Gly Ser His Ala Asp Phe Arg Gly Arg Asp Leu Ser Asp Leu Asp           
    190                 195                 200                           

ttt agg gcc aga gaa cag tcc cgt tct gat ttt agg aat aga gat gta        793
Phe Arg Ala Arg Glu Gln Ser Arg Ser Asp Phe Arg Asn Arg Asp Val           
205                 210                 215                 220           

tct gat ttg gac ttt aga gac aaa gac gga aca caa gta gac ttt aga        841
Ser Asp Leu Asp Phe Arg Asp Lys Asp Gly Thr Gln Val Asp Phe Arg           
                225                 230                 235               

ggc cga ggt tca ggt act act gat cta gac ttt agg gac agg gat acg        889
Gly Arg Gly Ser Gly Thr Thr Asp Leu Asp Phe Arg Asp Arg Asp Thr           
            240                 245                 250                   

cca cat tca gat ttc aga ggt aga cac cga tct agg act gat cag gat        937
Pro His Ser Asp Phe Arg Gly Arg His Arg Ser Arg Thr Asp Gln Asp           
        255                 260                 265                       

ttt agg ggc aga gag atg gga tct tgt atg gaa ttt aaa gat agg gag        985
Phe Arg Gly Arg Glu Met Gly Ser Cys Met Glu Phe Lys Asp Arg Glu           
    270                 275                 280                           

atg ccc cct gtg gat cca aat att ttg gat tac att cag ccc tct aca       1033
Met Pro Pro Val Asp Pro Asn Ile Leu Asp Tyr Ile Gln Pro Ser Thr           
285                 290                 295                 300           

caa gat aga gaa cat tct ggt atg aat gtg aac agg aga gaa gaa tcc       1081
Gln Asp Arg Glu His Ser Gly Met Asn Val Asn Arg Arg Glu Glu Ser           
                305                 310                 315               

aca cat gac cat acg ata gaa agg cct gct ttt ggc att cag aag gga       1129
Thr His Asp His Thr Ile Glu Arg Pro Ala Phe Gly Ile Gln Lys Gly           
            320                 325                 330                   

gaa ttt gag cat tca gaa aca aga gaa gga gaa aca caa ggt gta gcc       1177
Glu Phe Glu His Ser Glu Thr Arg Glu Gly Glu Thr Gln Gly Val Ala           
        335                 340                 345                       

ttt gaa cat gag tct cca gca gac ttt cag aac agc caa agt cca gtt       1225
Phe Glu His Glu Ser Pro Ala Asp Phe Gln Asn Ser Gln Ser Pro Val           
    350                 355                 360                           

caa gac caa gat aag tca cag ctt tct gga cgt gaa gag cag agt tca       1273
Gln Asp Gln Asp Lys Ser Gln Leu Ser Gly Arg Glu Glu Gln Ser Ser           
365                 370                 375                 380           

gat gct ggt ctg ttt aaa gaa gaa ggc ggt ctg gac ttt ctt ggg cgg       1321
Asp Ala Gly Leu Phe Lys Glu Glu Gly Gly Leu Asp Phe Leu Gly Arg           
                385                 390                 395               

caa gac acc gat tac aga agc atg gag tac cgt gat gtg gat cat agg       1369
Gln Asp Thr Asp Tyr Arg Ser Met Glu Tyr Arg Asp Val Asp His Arg           
            400                 405                 410                   

ctg cca gga agc cag atg ttt ggc tat ggc cag agc aag tct ttt cca       1417
Leu Pro Gly Ser Gln Met Phe Gly Tyr Gly Gln Ser Lys Ser Phe Pro           
        415                 420                 425                       

gag ggc aaa act gcc cga gat gcc caa cgg gac ctt cag gat caa gat       1465
Glu Gly Lys Thr Ala Arg Asp Ala Gln Arg Asp Leu Gln Asp Gln Asp           
    430                 435                 440                           

tat agg acc ggc cca agt gag gag aaa ccc agc agg ctt att cga tta       1513
Tyr Arg Thr Gly Pro Ser Glu Glu Lys Pro Ser Arg Leu Ile Arg Leu           
445                 450                 455                 460           

agt ggg gta cct gaa gat gcc aca aaa gaa gag att ctt aat gct ttt       1561
Ser Gly Val Pro Glu Asp Ala Thr Lys Glu Glu Ile Leu Asn Ala Phe           
                465                 470                 475               

cgg act cct gat ggc atg cct gta aag aac ttg cag ttg aag gag tat       1609
Arg Thr Pro Asp Gly Met Pro Val Lys Asn Leu Gln Leu Lys Glu Tyr           
            480                 485                 490                   

aac aca ggt tac gac tat ggc tat gtc tgc gtg gag ttt tca ctc ttg       1657
Asn Thr Gly Tyr Asp Tyr Gly Tyr Val Cys Val Glu Phe Ser Leu Leu           
        495                 500                 505                       

gaa gat gcc atc gga tgc atg gag gcc aac cag gga act cta atg atc       1705
Glu Asp Ala Ile Gly Cys Met Glu Ala Asn Gln Gly Thr Leu Met Ile           
    510                 515                 520                           

cag gac aaa gaa gtt acc ctg gag tat gta tca agc ctg gat ttt tgg       1753
Gln Asp Lys Glu Val Thr Leu Glu Tyr Val Ser Ser Leu Asp Phe Trp           
525                 530                 535                 540           

tac tgc aaa cga tgt aag gca aac att ggt ggg cac cga tct tcc tgt       1801
Tyr Cys Lys Arg Cys Lys Ala Asn Ile Gly Gly His Arg Ser Ser Cys           
                545                 550                 555               

tca ttc tgc aag aac cca aga gaa gtg aca gag gcc aag caa gaa tta       1849
Ser Phe Cys Lys Asn Pro Arg Glu Val Thr Glu Ala Lys Gln Glu Leu           
            560                 565                 570                   

ata acc tac cct cag cct cag aaa aca tcc ata cca gca cca ttg gaa       1897
Ile Thr Tyr Pro Gln Pro Gln Lys Thr Ser Ile Pro Ala Pro Leu Glu           
        575                 580                 585                       

aaa cag ccc aac cag ccc cta aga cca gct gat aag gaa cct gaa ccc       1945
Lys Gln Pro Asn Gln Pro Leu Arg Pro Ala Asp Lys Glu Pro Glu Pro           
    590                 595                 600                           

agg aag agg gaa gaa ggc caa gag tca cgc tta gga cat caa aag aga       1993
Arg Lys Arg Glu Glu Gly Gln Glu Ser Arg Leu Gly His Gln Lys Arg           
605                 610                 615                 620           

gaa gca gaa agg tat ctg cct cct tct cga agg gaa ggg cca act ttc       2041
Glu Ala Glu Arg Tyr Leu Pro Pro Ser Arg Arg Glu Gly Pro Thr Phe           
                625                 630                 635               

cga aga gac cga gag agg gag tca tgg tct gga gag aca cgc cag gat       2089
Arg Arg Asp Arg Glu Arg Glu Ser Trp Ser Gly Glu Thr Arg Gln Asp           
            640                 645                 650                   

gga gag agc aaa act atc atg cta aag cgt atc tat cgt tcc aca cca       2137
Gly Glu Ser Lys Thr Ile Met Leu Lys Arg Ile Tyr Arg Ser Thr Pro           
        655                 660                 665                       

cct gag gtg ata gtg gaa gtg ctg gag ccc tat gtc cgc ctt act act       2185
Pro Glu Val Ile Val Glu Val Leu Glu Pro Tyr Val Arg Leu Thr Thr           
    670                 675                 680                           

gcc aac gtc cgt atc atc aag aac aga aca ggc cct atg ggg cat acc       2233
Ala Asn Val Arg Ile Ile Lys Asn Arg Thr Gly Pro Met Gly His Thr           
685                 690                 695                 700           

tat ggc ttt att gac ctc gac tcc cat gcg gaa gct ctt cgt gtg gtg       2281
Tyr Gly Phe Ile Asp Leu Asp Ser His Ala Glu Ala Leu Arg Val Val           
                705                 710                 715               

aag atc tta cag aac ctt gat ccg cca ttt agc att gat ggg aag atg       2329
Lys Ile Leu Gln Asn Leu Asp Pro Pro Phe Ser Ile Asp Gly Lys Met           
            720                 725                 730                   

gta gct gta aac ctg gcc act gga aaa cga aga aat gat tct ggg gac       2377
Val Ala Val Asn Leu Ala Thr Gly Lys Arg Arg Asn Asp Ser Gly Asp           
        735                 740                 745                       

cat tct gac cac atg cat tac tat cag ggt aaa aaa tat ttc cga gat       2425
His Ser Asp His Met His Tyr Tyr Gln Gly Lys Lys Tyr Phe Arg Asp           
    750                 755                 760                           

agg agg gga ggt ggc aga aat tca gac tgg tct tca gat aca aat cga       2473
Arg Arg Gly Gly Gly Arg Asn Ser Asp Trp Ser Ser Asp Thr Asn Arg           
765                 770                 775                 780           

caa gga caa cag tca tca tct gac tgc tac ata tat gat tct gct act       2521
Gln Gly Gln Gln Ser Ser Ser Asp Cys Tyr Ile Tyr Asp Ser Ala Thr           
                785                 790                 795               

ggc tac tat tat gac ccc ttg gca gga act tat tat gac ccc aat acc       2569
Gly Tyr Tyr Tyr Asp Pro Leu Ala Gly Thr Tyr Tyr Asp Pro Asn Thr           
            800                 805                 810                   

cag caa gaa gtc tat gtg ccc cag gat cct gga tta cct gag gaa gaa       2617
Gln Gln Glu Val Tyr Val Pro Gln Asp Pro Gly Leu Pro Glu Glu Glu           
        815                 820                 825                       

gag atc aag gaa aaa aaa ccc acc agt caa gga aag tca agt agc aag       2665
Glu Ile Lys Glu Lys Lys Pro Thr Ser Gln Gly Lys Ser Ser Ser Lys           
    830                 835                 840                           

aag gaa atg tct aaa aga gat ggc aag gag aaa aaa gac aga gga gtg       2713
Lys Glu Met Ser Lys Arg Asp Gly Lys Glu Lys Lys Asp Arg Gly Val           
845                 850                 855                 860           

acg agg ttt cag gaa aat gcc agt gaa ggg aag gcc cct gca gaa gac       2761
Thr Arg Phe Gln Glu Asn Ala Ser Glu Gly Lys Ala Pro Ala Glu Asp           
                865                 870                 875               

gtc ttt aag aag ccc ctg cct cct act gtg aag aag gaa gag agt ccc       2809
Val Phe Lys Lys Pro Leu Pro Pro Thr Val Lys Lys Glu Glu Ser Pro           
            880                 885                 890                   

cct cca cct aaa gtg gta aac cca ctg atc ggc ctc ttg ggt gaa tat       2857
Pro Pro Pro Lys Val Val Asn Pro Leu Ile Gly Leu Leu Gly Glu Tyr           
        895                 900                 905                       

gga gga gac agt gac tat gag gag gaa gaa gag gag gaa cag acc cct       2905
Gly Gly Asp Ser Asp Tyr Glu Glu Glu Glu Glu Glu Glu Gln Thr Pro           
    910                 915                 920                           

ccc cca cag ccc cgc aca gca cag ccc cag aag cga gag gag caa acc       2953
Pro Pro Gln Pro Arg Thr Ala Gln Pro Gln Lys Arg Glu Glu Gln Thr           
925                 930                 935                 940           

aag aag gag aat gaa gaa gac aaa ctc act gac tgg aat aaa ctg gct       3001
Lys Lys Glu Asn Glu Glu Asp Lys Leu Thr Asp Trp Asn Lys Leu Ala           
                945                 950                 955               

tgt ctg ctt tgc aga agg cag ttt ccc aat aaa gaa gtt ctg atc aaa       3049
Cys Leu Leu Cys Arg Arg Gln Phe Pro Asn Lys Glu Val Leu Ile Lys           
            960                 965                 970                   

cac cag cag ctg tca gac ctg cac aag caa aac ctg gaa atc cac cgg       3097
His Gln Gln Leu Ser Asp Leu His Lys Gln Asn Leu Glu Ile His Arg           
        975                 980                 985                       

aag ata aaa cag tct gag cag gag cta gcc tat ctg  gaa agg aga gaa      3145
Lys Ile Lys Gln Ser Glu Gln Glu Leu Ala Tyr Leu  Glu Arg Arg Glu          
    990                 995                 1000                          

cga  gag gga aag ttt aaa  gga aga gga aat gat  cgc agg gaa aag        3190
Arg  Glu Gly Lys Phe Lys  Gly Arg Gly Asn Asp  Arg Arg Glu Lys            
1005                 1010                 1015                            

ctc  cag tct ttt gac tct  cca gaa agg aaa cgg  att aag tac tcc        3235
Leu  Gln Ser Phe Asp Ser  Pro Glu Arg Lys Arg  Ile Lys Tyr Ser            
1020                 1025                 1030                            

agg  gaa act gac agt gat  cgt aaa ctt gtt gat  aaa gaa gat atc        3280
Arg  Glu Thr Asp Ser Asp  Arg Lys Leu Val Asp  Lys Glu Asp Ile            
1035                 1040                 1045                            

gac  act agc agc aaa gga  ggc tgt gtc caa cag  gct act ggc tgg        3325
Asp  Thr Ser Ser Lys Gly  Gly Cys Val Gln Gln  Ala Thr Gly Trp            
1050                 1055                 1060                            

agg  aaa ggg aca ggc ctg  gga tat ggc cat cct  gga ttg gct tca        3370
Arg  Lys Gly Thr Gly Leu  Gly Tyr Gly His Pro  Gly Leu Ala Ser            
1065                 1070                 1075                            

tca  gag gag gct gaa ggc  cgg atg agg ggc ccc  agt gtt gga gcc        3415
Ser  Glu Glu Ala Glu Gly  Arg Met Arg Gly Pro  Ser Val Gly Ala            
1080                 1085                 1090                            

tca  gga aga acc agc aaa  aga cag tcc aac gag  act tat cga gat        3460
Ser  Gly Arg Thr Ser Lys  Arg Gln Ser Asn Glu  Thr Tyr Arg Asp            
1095                 1100                 1105                            

gct  gtt cga aga gtc atg  ttt gct cga tat aaa  gaa ctc gat taa        3505
Ala  Val Arg Arg Val Met  Phe Ala Arg Tyr Lys  Glu Leu Asp                
1110                 1115                 1120                            

gaaaggagac aagttccatg ggatacaacc tccctcttgt tttgtttgtc tctccttttc     3565

ttttgttact gttcttgctg ctagaacttt tttaaataaa ctttttttca atgtgaaaaa     3625

aaaaaaaaaa aaaa                                                       3639


<210>  658
<211>  1123
<212>  PRT
<213>  Homo sapiens

<400>  658

Met Trp Gly Asp Ser Arg Pro Ala Asn Arg Thr Gly Pro Phe Arg Gly 
1               5                   10                  15      


Ser Gln Glu Glu Arg Phe Ala Pro Gly Trp Asn Arg Asp Tyr Pro Pro 
            20                  25                  30          


Pro Pro Leu Lys Ser His Ala Gln Glu Arg His Ser Gly Asn Phe Pro 
        35                  40                  45              


Gly Arg Asp Ser Leu Pro Phe Asp Phe Gln Gly His Ser Gly Pro Pro 
    50                  55                  60                  


Phe Ala Asn Val Glu Glu His Ser Phe Ser Tyr Gly Ala Arg Asp Gly 
65                  70                  75                  80  


Pro His Gly Asp Tyr Arg Gly Gly Glu Gly Pro Gly His Asp Phe Arg 
                85                  90                  95      


Gly Gly Asp Phe Ser Ser Ser Asp Phe Gln Ser Arg Asp Ser Ser Gln 
            100                 105                 110         


Leu Asp Phe Arg Gly Arg Asp Ile His Ser Gly Asp Phe Arg Asp Arg 
        115                 120                 125             


Glu Gly Pro Pro Met Asp Tyr Arg Gly Gly Asp Gly Thr Ser Met Asp 
    130                 135                 140                 


Tyr Arg Gly Arg Glu Ala Pro His Met Asn Tyr Arg Asp Arg Asp Ala 
145                 150                 155                 160 


His Ala Val Asp Phe Arg Gly Arg Asp Ala Pro Pro Ser Asp Phe Arg 
                165                 170                 175     


Gly Arg Gly Thr Tyr Asp Leu Asp Phe Arg Gly Arg Asp Gly Ser His 
            180                 185                 190         


Ala Asp Phe Arg Gly Arg Asp Leu Ser Asp Leu Asp Phe Arg Ala Arg 
        195                 200                 205             


Glu Gln Ser Arg Ser Asp Phe Arg Asn Arg Asp Val Ser Asp Leu Asp 
    210                 215                 220                 


Phe Arg Asp Lys Asp Gly Thr Gln Val Asp Phe Arg Gly Arg Gly Ser 
225                 230                 235                 240 


Gly Thr Thr Asp Leu Asp Phe Arg Asp Arg Asp Thr Pro His Ser Asp 
                245                 250                 255     


Phe Arg Gly Arg His Arg Ser Arg Thr Asp Gln Asp Phe Arg Gly Arg 
            260                 265                 270         


Glu Met Gly Ser Cys Met Glu Phe Lys Asp Arg Glu Met Pro Pro Val 
        275                 280                 285             


Asp Pro Asn Ile Leu Asp Tyr Ile Gln Pro Ser Thr Gln Asp Arg Glu 
    290                 295                 300                 


His Ser Gly Met Asn Val Asn Arg Arg Glu Glu Ser Thr His Asp His 
305                 310                 315                 320 


Thr Ile Glu Arg Pro Ala Phe Gly Ile Gln Lys Gly Glu Phe Glu His 
                325                 330                 335     


Ser Glu Thr Arg Glu Gly Glu Thr Gln Gly Val Ala Phe Glu His Glu 
            340                 345                 350         


Ser Pro Ala Asp Phe Gln Asn Ser Gln Ser Pro Val Gln Asp Gln Asp 
        355                 360                 365             


Lys Ser Gln Leu Ser Gly Arg Glu Glu Gln Ser Ser Asp Ala Gly Leu 
    370                 375                 380                 


Phe Lys Glu Glu Gly Gly Leu Asp Phe Leu Gly Arg Gln Asp Thr Asp 
385                 390                 395                 400 


Tyr Arg Ser Met Glu Tyr Arg Asp Val Asp His Arg Leu Pro Gly Ser 
                405                 410                 415     


Gln Met Phe Gly Tyr Gly Gln Ser Lys Ser Phe Pro Glu Gly Lys Thr 
            420                 425                 430         


Ala Arg Asp Ala Gln Arg Asp Leu Gln Asp Gln Asp Tyr Arg Thr Gly 
        435                 440                 445             


Pro Ser Glu Glu Lys Pro Ser Arg Leu Ile Arg Leu Ser Gly Val Pro 
    450                 455                 460                 


Glu Asp Ala Thr Lys Glu Glu Ile Leu Asn Ala Phe Arg Thr Pro Asp 
465                 470                 475                 480 


Gly Met Pro Val Lys Asn Leu Gln Leu Lys Glu Tyr Asn Thr Gly Tyr 
                485                 490                 495     


Asp Tyr Gly Tyr Val Cys Val Glu Phe Ser Leu Leu Glu Asp Ala Ile 
            500                 505                 510         


Gly Cys Met Glu Ala Asn Gln Gly Thr Leu Met Ile Gln Asp Lys Glu 
        515                 520                 525             


Val Thr Leu Glu Tyr Val Ser Ser Leu Asp Phe Trp Tyr Cys Lys Arg 
    530                 535                 540                 


Cys Lys Ala Asn Ile Gly Gly His Arg Ser Ser Cys Ser Phe Cys Lys 
545                 550                 555                 560 


Asn Pro Arg Glu Val Thr Glu Ala Lys Gln Glu Leu Ile Thr Tyr Pro 
                565                 570                 575     


Gln Pro Gln Lys Thr Ser Ile Pro Ala Pro Leu Glu Lys Gln Pro Asn 
            580                 585                 590         


Gln Pro Leu Arg Pro Ala Asp Lys Glu Pro Glu Pro Arg Lys Arg Glu 
        595                 600                 605             


Glu Gly Gln Glu Ser Arg Leu Gly His Gln Lys Arg Glu Ala Glu Arg 
    610                 615                 620                 


Tyr Leu Pro Pro Ser Arg Arg Glu Gly Pro Thr Phe Arg Arg Asp Arg 
625                 630                 635                 640 


Glu Arg Glu Ser Trp Ser Gly Glu Thr Arg Gln Asp Gly Glu Ser Lys 
                645                 650                 655     


Thr Ile Met Leu Lys Arg Ile Tyr Arg Ser Thr Pro Pro Glu Val Ile 
            660                 665                 670         


Val Glu Val Leu Glu Pro Tyr Val Arg Leu Thr Thr Ala Asn Val Arg 
        675                 680                 685             


Ile Ile Lys Asn Arg Thr Gly Pro Met Gly His Thr Tyr Gly Phe Ile 
    690                 695                 700                 


Asp Leu Asp Ser His Ala Glu Ala Leu Arg Val Val Lys Ile Leu Gln 
705                 710                 715                 720 


Asn Leu Asp Pro Pro Phe Ser Ile Asp Gly Lys Met Val Ala Val Asn 
                725                 730                 735     


Leu Ala Thr Gly Lys Arg Arg Asn Asp Ser Gly Asp His Ser Asp His 
            740                 745                 750         


Met His Tyr Tyr Gln Gly Lys Lys Tyr Phe Arg Asp Arg Arg Gly Gly 
        755                 760                 765             


Gly Arg Asn Ser Asp Trp Ser Ser Asp Thr Asn Arg Gln Gly Gln Gln 
    770                 775                 780                 


Ser Ser Ser Asp Cys Tyr Ile Tyr Asp Ser Ala Thr Gly Tyr Tyr Tyr 
785                 790                 795                 800 


Asp Pro Leu Ala Gly Thr Tyr Tyr Asp Pro Asn Thr Gln Gln Glu Val 
                805                 810                 815     


Tyr Val Pro Gln Asp Pro Gly Leu Pro Glu Glu Glu Glu Ile Lys Glu 
            820                 825                 830         


Lys Lys Pro Thr Ser Gln Gly Lys Ser Ser Ser Lys Lys Glu Met Ser 
        835                 840                 845             


Lys Arg Asp Gly Lys Glu Lys Lys Asp Arg Gly Val Thr Arg Phe Gln 
    850                 855                 860                 


Glu Asn Ala Ser Glu Gly Lys Ala Pro Ala Glu Asp Val Phe Lys Lys 
865                 870                 875                 880 


Pro Leu Pro Pro Thr Val Lys Lys Glu Glu Ser Pro Pro Pro Pro Lys 
                885                 890                 895     


Val Val Asn Pro Leu Ile Gly Leu Leu Gly Glu Tyr Gly Gly Asp Ser 
            900                 905                 910         


Asp Tyr Glu Glu Glu Glu Glu Glu Glu Gln Thr Pro Pro Pro Gln Pro 
        915                 920                 925             


Arg Thr Ala Gln Pro Gln Lys Arg Glu Glu Gln Thr Lys Lys Glu Asn 
    930                 935                 940                 


Glu Glu Asp Lys Leu Thr Asp Trp Asn Lys Leu Ala Cys Leu Leu Cys 
945                 950                 955                 960 


Arg Arg Gln Phe Pro Asn Lys Glu Val Leu Ile Lys His Gln Gln Leu 
                965                 970                 975     


Ser Asp Leu His Lys Gln Asn Leu Glu Ile His Arg Lys Ile Lys Gln 
            980                 985                 990         


Ser Glu Gln Glu Leu Ala Tyr Leu  Glu Arg Arg Glu Arg  Glu Gly Lys 
        995                 1000                 1005             


Phe Lys  Gly Arg Gly Asn Asp  Arg Arg Glu Lys Leu  Gln Ser Phe 
    1010                 1015                 1020             


Asp Ser  Pro Glu Arg Lys Arg  Ile Lys Tyr Ser Arg  Glu Thr Asp 
    1025                 1030                 1035             


Ser Asp  Arg Lys Leu Val Asp  Lys Glu Asp Ile Asp  Thr Ser Ser 
    1040                 1045                 1050             


Lys Gly  Gly Cys Val Gln Gln  Ala Thr Gly Trp Arg  Lys Gly Thr 
    1055                 1060                 1065             


Gly Leu  Gly Tyr Gly His Pro  Gly Leu Ala Ser Ser  Glu Glu Ala 
    1070                 1075                 1080             


Glu Gly  Arg Met Arg Gly Pro  Ser Val Gly Ala Ser  Gly Arg Thr 
    1085                 1090                 1095             


Ser Lys  Arg Gln Ser Asn Glu  Thr Tyr Arg Asp Ala  Val Arg Arg 
    1100                 1105                 1110             


Val Met  Phe Ala Arg Tyr Lys  Glu Leu Asp 
    1115                 1120             


<210>  659
<211>  826
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (172)..(669)

<400>  659
tcatgtgaca aagcgcagga cccctcactg ccccaactgc ttgctgttct ctctttcttg       60

ggctctaagg acccaggagt ctgggtgcac agcctccttc tctctgagat tcaagagtct      120

gatcagcagc ctcttcctcc tccaggaccc agaagccctg agcttatccc c atg gag       177
                                                         Met Glu          
                                                         1                

ctc tgc cgg tcc ctg gcc ctg ctg ggg ggc tcc ctg ggc ctg atg ttc        225
Leu Cys Arg Ser Leu Ala Leu Leu Gly Gly Ser Leu Gly Leu Met Phe           
        5                   10                  15                        

tgc ctg att gct ttg agc acc gat ttc tgg ttt gag gct gtg ggt ccc        273
Cys Leu Ile Ala Leu Ser Thr Asp Phe Trp Phe Glu Ala Val Gly Pro           
    20                  25                  30                            

acc cac tca gct cac tcg ggc ctc tgg cca aca ggg cat ggg gac atc        321
Thr His Ser Ala His Ser Gly Leu Trp Pro Thr Gly His Gly Asp Ile           
35                  40                  45                  50            

ata tca ggc tac atc cac gtg acg cag acc ttc agc att atg gct gtt        369
Ile Ser Gly Tyr Ile His Val Thr Gln Thr Phe Ser Ile Met Ala Val           
                55                  60                  65                

ctg tgg gcc ctg gtg tcc gtg agc ttc ctg gtc ctg tcc tgc ttc ccc        417
Leu Trp Ala Leu Val Ser Val Ser Phe Leu Val Leu Ser Cys Phe Pro           
            70                  75                  80                    

tca ctg ttc ccc cca ggc cac ggc ccg ctt gtc tca acc acc gca gcc        465
Ser Leu Phe Pro Pro Gly His Gly Pro Leu Val Ser Thr Thr Ala Ala           
        85                  90                  95                        

ttt gct gca gcc atc tcc atg gtg gtg gcc atg gcg gtg tac acc agc        513
Phe Ala Ala Ala Ile Ser Met Val Val Ala Met Ala Val Tyr Thr Ser           
    100                 105                 110                           

gag cgg tgg gac cag cct cca cac ccc cag atc cag acc ttc ttc tcc        561
Glu Arg Trp Asp Gln Pro Pro His Pro Gln Ile Gln Thr Phe Phe Ser           
115                 120                 125                 130           

tgg tcc ttc tac ctg ggc tgg gtc tca gct atc ctc ttg ctc tgt aca        609
Trp Ser Phe Tyr Leu Gly Trp Val Ser Ala Ile Leu Leu Leu Cys Thr           
                135                 140                 145               

ggt gcc ctg agc ctg ggt gct cac tgt ggc ggt ccc cgt cct ggc tat        657
Gly Ala Leu Ser Leu Gly Ala His Cys Gly Gly Pro Arg Pro Gly Tyr           
            150                 155                 160                   

gaa acc ttg tga gcagaaggca agagcggcaa gatgagtttt gagcgttgta            709
Glu Thr Leu                                                               
        165                                                               

ttccaaaggc ctcatctgga gcctcgggaa agtctggtcc cacatctgcc cgcccttcca      769

gcccttcccc agcccctcct cttgtttctt cattcattca acaaaatttg gctggaa         826


<210>  660
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  660

Met Glu Leu Cys Arg Ser Leu Ala Leu Leu Gly Gly Ser Leu Gly Leu 
1               5                   10                  15      


Met Phe Cys Leu Ile Ala Leu Ser Thr Asp Phe Trp Phe Glu Ala Val 
            20                  25                  30          


Gly Pro Thr His Ser Ala His Ser Gly Leu Trp Pro Thr Gly His Gly 
        35                  40                  45              


Asp Ile Ile Ser Gly Tyr Ile His Val Thr Gln Thr Phe Ser Ile Met 
    50                  55                  60                  


Ala Val Leu Trp Ala Leu Val Ser Val Ser Phe Leu Val Leu Ser Cys 
65                  70                  75                  80  


Phe Pro Ser Leu Phe Pro Pro Gly His Gly Pro Leu Val Ser Thr Thr 
                85                  90                  95      


Ala Ala Phe Ala Ala Ala Ile Ser Met Val Val Ala Met Ala Val Tyr 
            100                 105                 110         


Thr Ser Glu Arg Trp Asp Gln Pro Pro His Pro Gln Ile Gln Thr Phe 
        115                 120                 125             


Phe Ser Trp Ser Phe Tyr Leu Gly Trp Val Ser Ala Ile Leu Leu Leu 
    130                 135                 140                 


Cys Thr Gly Ala Leu Ser Leu Gly Ala His Cys Gly Gly Pro Arg Pro 
145                 150                 155                 160 


Gly Tyr Glu Thr Leu 
                165 


<210>  661
<211>  745
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (74)..(580)

<400>  661
gtcgggtacg ggaaggtcca agccgctgcc gggtgcccga gggccgtcgt ggccgccgtc       60

gccacgggtc cca atg gag ccg ccg aat ctc tat ccg gtg aag ctc tac         109
               Met Glu Pro Pro Asn Leu Tyr Pro Val Lys Leu Tyr            
               1               5                   10                     

gtg tac gac ctg tcc aaa ggc ctg gcc cgg cgg ctc agc ccc atc atg        157
Val Tyr Asp Leu Ser Lys Gly Leu Ala Arg Arg Leu Ser Pro Ile Met           
        15                  20                  25                        

ctg ggg aaa caa ctg gaa ggc atc tgg cac aca tcc ata gtt gtg cac        205
Leu Gly Lys Gln Leu Glu Gly Ile Trp His Thr Ser Ile Val Val His           
    30                  35                  40                            

aag gat gag ttc ttc ttc ggc agt ggt ggt atc tcc agc tgc ccc ccg        253
Lys Asp Glu Phe Phe Phe Gly Ser Gly Gly Ile Ser Ser Cys Pro Pro           
45                  50                  55                  60            

gga ggg aca ttg ctt ggg cct cca gac tct gtg gtt gat gtg ggg agt        301
Gly Gly Thr Leu Leu Gly Pro Pro Asp Ser Val Val Asp Val Gly Ser           
                65                  70                  75                

aca gaa gtc aca gaa gaa atc ttt ctg gag tac ctc tcc tcc ctg ggg        349
Thr Glu Val Thr Glu Glu Ile Phe Leu Glu Tyr Leu Ser Ser Leu Gly           
            80                  85                  90                    

gag tcc ctg ttc cga ggt gag gcc tac aac ctc ttt gaa cac aat tgt        397
Glu Ser Leu Phe Arg Gly Glu Ala Tyr Asn Leu Phe Glu His Asn Cys           
        95                  100                 105                       

aac acc ttc agc aac gaa gtg gca cag ttc ctg act ggg cgg aag att        445
Asn Thr Phe Ser Asn Glu Val Ala Gln Phe Leu Thr Gly Arg Lys Ile           
    110                 115                 120                           

cct tct tac atc aca gac ctg ccc tct gaa gtt ctc tcc acg ccc ttt        493
Pro Ser Tyr Ile Thr Asp Leu Pro Ser Glu Val Leu Ser Thr Pro Phe           
125                 130                 135                 140           

gga cag gca ctt cgg ccc ctc ctg gac tcc att cag atc cag cct cca        541
Gly Gln Ala Leu Arg Pro Leu Leu Asp Ser Ile Gln Ile Gln Pro Pro           
                145                 150                 155               

gga ggg agc tcc gtg ggc aga ccc aac ggc cag agc taa caggactgcc         590
Gly Gly Ser Ser Val Gly Arg Pro Asn Gly Gln Ser                           
            160                 165                                       

tgggaccgcc ctgcctcacc agggcttttc ctttttaaac aaaacaaacc ctaccagatt      650

tctattttat aattttacat cagagctaac aaccagggga cggcttttta aatttcccag      710

ggaaggagac cgtcaggccg catgtagaca atgct                                 745


<210>  662
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  662

Met Glu Pro Pro Asn Leu Tyr Pro Val Lys Leu Tyr Val Tyr Asp Leu 
1               5                   10                  15      


Ser Lys Gly Leu Ala Arg Arg Leu Ser Pro Ile Met Leu Gly Lys Gln 
            20                  25                  30          


Leu Glu Gly Ile Trp His Thr Ser Ile Val Val His Lys Asp Glu Phe 
        35                  40                  45              


Phe Phe Gly Ser Gly Gly Ile Ser Ser Cys Pro Pro Gly Gly Thr Leu 
    50                  55                  60                  


Leu Gly Pro Pro Asp Ser Val Val Asp Val Gly Ser Thr Glu Val Thr 
65                  70                  75                  80  


Glu Glu Ile Phe Leu Glu Tyr Leu Ser Ser Leu Gly Glu Ser Leu Phe 
                85                  90                  95      


Arg Gly Glu Ala Tyr Asn Leu Phe Glu His Asn Cys Asn Thr Phe Ser 
            100                 105                 110         


Asn Glu Val Ala Gln Phe Leu Thr Gly Arg Lys Ile Pro Ser Tyr Ile 
        115                 120                 125             


Thr Asp Leu Pro Ser Glu Val Leu Ser Thr Pro Phe Gly Gln Ala Leu 
    130                 135                 140                 


Arg Pro Leu Leu Asp Ser Ile Gln Ile Gln Pro Pro Gly Gly Ser Ser 
145                 150                 155                 160 


Val Gly Arg Pro Asn Gly Gln Ser 
                165             


<210>  663
<211>  526
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (55)..(408)

<400>  663
tggttcctgc cgtccggact ctttttcctc tactgagatt catctgtgtg aaat atg         57
                                                            Met           
                                                            1             

agt tgg cga gga aga tcg acc tat tat tgg cct aga cca agg cgc tat        105
Ser Trp Arg Gly Arg Ser Thr Tyr Tyr Trp Pro Arg Pro Arg Arg Tyr           
            5                   10                  15                    

gta cag cct cct gaa atg att ggg cct atg cgg ccc gag cag ttc agt        153
Val Gln Pro Pro Glu Met Ile Gly Pro Met Arg Pro Glu Gln Phe Ser           
        20                  25                  30                        

gat gaa gtg gaa cca gca aca cct gaa gaa ggg gaa cca gca act caa        201
Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr Gln           
    35                  40                  45                            

cgt cag gat cct gca gct gct cag gag gga gag gat gag gga gca tct        249
Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala Ser           
50                  55                  60                  65            

gca ggt caa ggg ccg aag cct gaa gct cat agc cag gaa cag ggt cac        297
Ala Gly Gln Gly Pro Lys Pro Glu Ala His Ser Gln Glu Gln Gly His           
                70                  75                  80                

cca cag act ggg tgt gag tgt gaa gat ggt cct gat ggg cag gag atg        345
Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu Met           
            85                  90                  95                    

gac ccg cca aat cca gag gag gtg aaa acg cct gaa gaa ggt gaa aag        393
Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Gly Glu Lys           
        100                 105                 110                       

caa tca cag tgt taa aagaaggcac gttgaaatga tgcaggctgc tcctatgttg        448
Gln Ser Gln Cys                                                           
    115                                                                   

gaaatttgtt cattaaaatt ctcccaataa agctttacag ccttctgcaa agaaaaaaaa      508

aaaaaaaaaa aaaaaaaa                                                    526


<210>  664
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  664

Met Ser Trp Arg Gly Arg Ser Thr Tyr Tyr Trp Pro Arg Pro Arg Arg 
1               5                   10                  15      


Tyr Val Gln Pro Pro Glu Met Ile Gly Pro Met Arg Pro Glu Gln Phe 
            20                  25                  30          


Ser Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr 
        35                  40                  45              


Gln Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala 
    50                  55                  60                  


Ser Ala Gly Gln Gly Pro Lys Pro Glu Ala His Ser Gln Glu Gln Gly 
65                  70                  75                  80  


His Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu 
                85                  90                  95      


Met Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Gly Glu 
            100                 105                 110         


Lys Gln Ser Gln Cys 
        115         


<210>  665
<211>  2622
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (34)..(2145)

<400>  665
aaccgtctcc tggttggggg gtggggggga aag atg gcg gag ctg atg ctg ctc        54
                                     Met Ala Glu Leu Met Leu Leu          
                                     1               5                    

agc gag att gct gac ccg acg cgt ttc ttc acc gac aac ctg ctt agc        102
Ser Glu Ile Ala Asp Pro Thr Arg Phe Phe Thr Asp Asn Leu Leu Ser           
        10                  15                  20                        

ccg gag gac tgg ggt ctg cag aac agc acc ttg tat tct ggc cta gat        150
Pro Glu Asp Trp Gly Leu Gln Asn Ser Thr Leu Tyr Ser Gly Leu Asp           
    25                  30                  35                            

gaa gtg gcc gag gag cag acg cag ctc ttc cgt tgc ccg gag cag gat        198
Glu Val Ala Glu Glu Gln Thr Gln Leu Phe Arg Cys Pro Glu Gln Asp           
40                  45                  50                  55            

gtc ccg ttt gac ggc agc tcc ctg gac gtg ggg atg gat gtc agc ccc        246
Val Pro Phe Asp Gly Ser Ser Leu Asp Val Gly Met Asp Val Ser Pro           
                60                  65                  70                

tct gag ccc cca tgg gaa ctc ctg ccg atc ttc cca gat ctt cag gtg        294
Ser Glu Pro Pro Trp Glu Leu Leu Pro Ile Phe Pro Asp Leu Gln Val           
            75                  80                  85                    

aag tct gag cca tct tcc ccc tgc tct tcc tcc tcc ctc agc tcc gag        342
Lys Ser Glu Pro Ser Ser Pro Cys Ser Ser Ser Ser Leu Ser Ser Glu           
        90                  95                  100                       

tca tcg cgt ctc tcc aca gag cca tcc agc gag gct ctt ggg gta ggg        390
Ser Ser Arg Leu Ser Thr Glu Pro Ser Ser Glu Ala Leu Gly Val Gly           
    105                 110                 115                           

gag gtg ctc cat gtg aag aca gag tcc ttg gca ccc cca ctg tgt ctc        438
Glu Val Leu His Val Lys Thr Glu Ser Leu Ala Pro Pro Leu Cys Leu           
120                 125                 130                 135           

ctg gga gat gac cca aca tcc tca ttt gaa acc gtc cag atc aac gtt        486
Leu Gly Asp Asp Pro Thr Ser Ser Phe Glu Thr Val Gln Ile Asn Val           
                140                 145                 150               

atc ccc acc tct gat gat tcc tca gat gtc cag acc aag ata gaa cct        534
Ile Pro Thr Ser Asp Asp Ser Ser Asp Val Gln Thr Lys Ile Glu Pro           
            155                 160                 165                   

gtc tct cca tgt tct tcc gtc aac tct gag gcc tcc ctg ctc tca gcc        582
Val Ser Pro Cys Ser Ser Val Asn Ser Glu Ala Ser Leu Leu Ser Ala           
        170                 175                 180                       

gac tcc tcc agc cag gct ttt ata gga gag gag gtc ctg gaa gtg aag        630
Asp Ser Ser Ser Gln Ala Phe Ile Gly Glu Glu Val Leu Glu Val Lys           
    185                 190                 195                           

aca gag tcc ctg tcc cct tca gga tgc ctc ctg tgg gat gtc cca gcc        678
Thr Glu Ser Leu Ser Pro Ser Gly Cys Leu Leu Trp Asp Val Pro Ala           
200                 205                 210                 215           

ccc tca ctt gga gct gtc cag atc agc atg ggc cca tcc ctt gat ggc        726
Pro Ser Leu Gly Ala Val Gln Ile Ser Met Gly Pro Ser Leu Asp Gly           
                220                 225                 230               

tcc tca ggc aaa gcc ctg ccc acc cgg aag ccg cca ctg cag ccc aaa        774
Ser Ser Gly Lys Ala Leu Pro Thr Arg Lys Pro Pro Leu Gln Pro Lys           
            235                 240                 245                   

cct gta gtg cta acc act gtc cca atg cca tcc aga gct gtg cct ccc        822
Pro Val Val Leu Thr Thr Val Pro Met Pro Ser Arg Ala Val Pro Pro           
        250                 255                 260                       

agc acc aca gtc ctt ctg cag tcc ctc gtc cag cca ccc cca gtg tcc        870
Ser Thr Thr Val Leu Leu Gln Ser Leu Val Gln Pro Pro Pro Val Ser           
    265                 270                 275                           

cca gtt gtc ctc atc cag ggt gct att cga gtc cag cct gaa ggg ccg        918
Pro Val Val Leu Ile Gln Gly Ala Ile Arg Val Gln Pro Glu Gly Pro           
280                 285                 290                 295           

gct ccc tct cta cca cgg cct gag agg aag agc atc gtt ccc gct cct        966
Ala Pro Ser Leu Pro Arg Pro Glu Arg Lys Ser Ile Val Pro Ala Pro           
                300                 305                 310               

atg cct gga aac tcc tgc ccg cct gaa gtg gat gca aag ctg ctg aag       1014
Met Pro Gly Asn Ser Cys Pro Pro Glu Val Asp Ala Lys Leu Leu Lys           
            315                 320                 325                   

cgg cag cag cga atg atc aag aac cgg gag tca gcc tgc cag tcc cgg       1062
Arg Gln Gln Arg Met Ile Lys Asn Arg Glu Ser Ala Cys Gln Ser Arg           
        330                 335                 340                       

aga aag aag aaa gag tat ctg cag gga ctg gag gct cgg ctg caa gca       1110
Arg Lys Lys Lys Glu Tyr Leu Gln Gly Leu Glu Ala Arg Leu Gln Ala           
    345                 350                 355                           

gta ctg gct gac aac cag cag ctc cgc cga gag aat gct gcc ctc cgg       1158
Val Leu Ala Asp Asn Gln Gln Leu Arg Arg Glu Asn Ala Ala Leu Arg           
360                 365                 370                 375           

cgg cgg ctg gag gcc ctg ctg gct gaa aac agc gag ctc aag tta ggg       1206
Arg Arg Leu Glu Ala Leu Leu Ala Glu Asn Ser Glu Leu Lys Leu Gly           
                380                 385                 390               

tct gga aac agg aag gtg gtc tgc atc atg gtc ttc ctt ctc ttc att       1254
Ser Gly Asn Arg Lys Val Val Cys Ile Met Val Phe Leu Leu Phe Ile           
            395                 400                 405                   

gcc ttc aac ttt gga cct gtc agc atc agt gag cct cct tca gct ccc       1302
Ala Phe Asn Phe Gly Pro Val Ser Ile Ser Glu Pro Pro Ser Ala Pro           
        410                 415                 420                       

atc tct cct cgg atg aac aag ggg gag cct caa ccc cgg aga cac ttg       1350
Ile Ser Pro Arg Met Asn Lys Gly Glu Pro Gln Pro Arg Arg His Leu           
    425                 430                 435                           

ctg ggg ttc tca gag caa gag cca gtt cag gga gtt gaa cct ctc cag       1398
Leu Gly Phe Ser Glu Gln Glu Pro Val Gln Gly Val Glu Pro Leu Gln           
440                 445                 450                 455           

ggg tcc tcc cag ggc cct aag gag ccc cag ccc agc ccc aca gac cag       1446
Gly Ser Ser Gln Gly Pro Lys Glu Pro Gln Pro Ser Pro Thr Asp Gln           
                460                 465                 470               

ccc agt ttc agc aac ctg aca gcc ttc cct ggg ggc gcc aag gag cta       1494
Pro Ser Phe Ser Asn Leu Thr Ala Phe Pro Gly Gly Ala Lys Glu Leu           
            475                 480                 485                   

cta cta aga gac cta gac cag ctc ttc ctc tcc tct gat tgc cgg cac       1542
Leu Leu Arg Asp Leu Asp Gln Leu Phe Leu Ser Ser Asp Cys Arg His           
        490                 495                 500                       

ttc aac cgc act gag tcc ctg agg ctt gct gac gag ttg agt ggc tgg       1590
Phe Asn Arg Thr Glu Ser Leu Arg Leu Ala Asp Glu Leu Ser Gly Trp           
    505                 510                 515                           

gtc cag cgc cac cag aga ggc cgg agg aag atc cct cag agg gcc cag       1638
Val Gln Arg His Gln Arg Gly Arg Arg Lys Ile Pro Gln Arg Ala Gln           
520                 525                 530                 535           

gag aga cag aag tct cag cca cgg aag aag tca cct cca gtt aag gca       1686
Glu Arg Gln Lys Ser Gln Pro Arg Lys Lys Ser Pro Pro Val Lys Ala           
                540                 545                 550               

gtc ccc atc caa ccc cct gga ccc cca gaa agg gat tct gtg ggc cag       1734
Val Pro Ile Gln Pro Pro Gly Pro Pro Glu Arg Asp Ser Val Gly Gln           
            555                 560                 565                   

ctg caa cta tat cgc cac cca gac cgt tcg cag cca gca ttc ttg gat       1782
Leu Gln Leu Tyr Arg His Pro Asp Arg Ser Gln Pro Ala Phe Leu Asp           
        570                 575                 580                       

gca att gac cga cgg gaa gac aca ttt tat gtt gtc tct ttc cga agg       1830
Ala Ile Asp Arg Arg Glu Asp Thr Phe Tyr Val Val Ser Phe Arg Arg           
    585                 590                 595                           

gac cac ctg ctg ctc cca gcc atc agc cac aac aag acc tcc cgg ccc       1878
Asp His Leu Leu Leu Pro Ala Ile Ser His Asn Lys Thr Ser Arg Pro           
600                 605                 610                 615           

aag atg tcc ctg gtg atg cct gcc atg gcc ccc aat gag acc ctg tca       1926
Lys Met Ser Leu Val Met Pro Ala Met Ala Pro Asn Glu Thr Leu Ser           
                620                 625                 630               

ggc cgt ggg gcc ccg ggg gac tat gag gag atg atg cag atc gag tgt       1974
Gly Arg Gly Ala Pro Gly Asp Tyr Glu Glu Met Met Gln Ile Glu Cys           
            635                 640                 645                   

gag gtc atg gac acc agg gtg att cac atc aag acc tcc aca gtg ccc       2022
Glu Val Met Asp Thr Arg Val Ile His Ile Lys Thr Ser Thr Val Pro           
        650                 655                 660                       

ccc tcg ctc cga aaa cag cca tcc cca acc cca ggc aat gcc aca ggt       2070
Pro Ser Leu Arg Lys Gln Pro Ser Pro Thr Pro Gly Asn Ala Thr Gly           
    665                 670                 675                           

ggc ccc ttg cca gtc tct gca gcc agc cag gcc cac cag gcc tcc cac       2118
Gly Pro Leu Pro Val Ser Ala Ala Ser Gln Ala His Gln Ala Ser His           
680                 685                 690                 695           

cag ccc ctc tac ctc aat cat ccc tga cctctgccat tcacactgac             2165
Gln Pro Leu Tyr Leu Asn His Pro                                           
                700                                                       

ttagaacggg gggagggggt accaggtggc caggtgggac tgtttcaaat ttccctgatc     2225

cccaggcttg gggcaattgg taaaggaaag agcaggtgtg ggggttaagc acttatttga     2285

ggtgggggtg ttcacctctc ttctcatccc ttttcagaat atagggctcc tctcattcct     2345

gtgaaccccc agtcctggct tctttgtttg aggggattgt gtgaggttca gttgtggggt     2405

gggtggtgag ctgctgcata ttttttattt tgtttctcta gtgttatggc agtggaggtg     2465

ggaatttagt ccccaggtgg gacaagggaa gttttttcat tttggagcta gttactggga     2525

gtaagggagg gtggggtggg ggggagttca ggtttatgtg tgtgcatttc ttttttatta     2585

ttattaaata aacaacttgg agggagttga aaaaaaa                              2622


<210>  666
<211>  703
<212>  PRT
<213>  Homo sapiens

<400>  666

Met Ala Glu Leu Met Leu Leu Ser Glu Ile Ala Asp Pro Thr Arg Phe 
1               5                   10                  15      


Phe Thr Asp Asn Leu Leu Ser Pro Glu Asp Trp Gly Leu Gln Asn Ser 
            20                  25                  30          


Thr Leu Tyr Ser Gly Leu Asp Glu Val Ala Glu Glu Gln Thr Gln Leu 
        35                  40                  45              


Phe Arg Cys Pro Glu Gln Asp Val Pro Phe Asp Gly Ser Ser Leu Asp 
    50                  55                  60                  


Val Gly Met Asp Val Ser Pro Ser Glu Pro Pro Trp Glu Leu Leu Pro 
65                  70                  75                  80  


Ile Phe Pro Asp Leu Gln Val Lys Ser Glu Pro Ser Ser Pro Cys Ser 
                85                  90                  95      


Ser Ser Ser Leu Ser Ser Glu Ser Ser Arg Leu Ser Thr Glu Pro Ser 
            100                 105                 110         


Ser Glu Ala Leu Gly Val Gly Glu Val Leu His Val Lys Thr Glu Ser 
        115                 120                 125             


Leu Ala Pro Pro Leu Cys Leu Leu Gly Asp Asp Pro Thr Ser Ser Phe 
    130                 135                 140                 


Glu Thr Val Gln Ile Asn Val Ile Pro Thr Ser Asp Asp Ser Ser Asp 
145                 150                 155                 160 


Val Gln Thr Lys Ile Glu Pro Val Ser Pro Cys Ser Ser Val Asn Ser 
                165                 170                 175     


Glu Ala Ser Leu Leu Ser Ala Asp Ser Ser Ser Gln Ala Phe Ile Gly 
            180                 185                 190         


Glu Glu Val Leu Glu Val Lys Thr Glu Ser Leu Ser Pro Ser Gly Cys 
        195                 200                 205             


Leu Leu Trp Asp Val Pro Ala Pro Ser Leu Gly Ala Val Gln Ile Ser 
    210                 215                 220                 


Met Gly Pro Ser Leu Asp Gly Ser Ser Gly Lys Ala Leu Pro Thr Arg 
225                 230                 235                 240 


Lys Pro Pro Leu Gln Pro Lys Pro Val Val Leu Thr Thr Val Pro Met 
                245                 250                 255     


Pro Ser Arg Ala Val Pro Pro Ser Thr Thr Val Leu Leu Gln Ser Leu 
            260                 265                 270         


Val Gln Pro Pro Pro Val Ser Pro Val Val Leu Ile Gln Gly Ala Ile 
        275                 280                 285             


Arg Val Gln Pro Glu Gly Pro Ala Pro Ser Leu Pro Arg Pro Glu Arg 
    290                 295                 300                 


Lys Ser Ile Val Pro Ala Pro Met Pro Gly Asn Ser Cys Pro Pro Glu 
305                 310                 315                 320 


Val Asp Ala Lys Leu Leu Lys Arg Gln Gln Arg Met Ile Lys Asn Arg 
                325                 330                 335     


Glu Ser Ala Cys Gln Ser Arg Arg Lys Lys Lys Glu Tyr Leu Gln Gly 
            340                 345                 350         


Leu Glu Ala Arg Leu Gln Ala Val Leu Ala Asp Asn Gln Gln Leu Arg 
        355                 360                 365             


Arg Glu Asn Ala Ala Leu Arg Arg Arg Leu Glu Ala Leu Leu Ala Glu 
    370                 375                 380                 


Asn Ser Glu Leu Lys Leu Gly Ser Gly Asn Arg Lys Val Val Cys Ile 
385                 390                 395                 400 


Met Val Phe Leu Leu Phe Ile Ala Phe Asn Phe Gly Pro Val Ser Ile 
                405                 410                 415     


Ser Glu Pro Pro Ser Ala Pro Ile Ser Pro Arg Met Asn Lys Gly Glu 
            420                 425                 430         


Pro Gln Pro Arg Arg His Leu Leu Gly Phe Ser Glu Gln Glu Pro Val 
        435                 440                 445             


Gln Gly Val Glu Pro Leu Gln Gly Ser Ser Gln Gly Pro Lys Glu Pro 
    450                 455                 460                 


Gln Pro Ser Pro Thr Asp Gln Pro Ser Phe Ser Asn Leu Thr Ala Phe 
465                 470                 475                 480 


Pro Gly Gly Ala Lys Glu Leu Leu Leu Arg Asp Leu Asp Gln Leu Phe 
                485                 490                 495     


Leu Ser Ser Asp Cys Arg His Phe Asn Arg Thr Glu Ser Leu Arg Leu 
            500                 505                 510         


Ala Asp Glu Leu Ser Gly Trp Val Gln Arg His Gln Arg Gly Arg Arg 
        515                 520                 525             


Lys Ile Pro Gln Arg Ala Gln Glu Arg Gln Lys Ser Gln Pro Arg Lys 
    530                 535                 540                 


Lys Ser Pro Pro Val Lys Ala Val Pro Ile Gln Pro Pro Gly Pro Pro 
545                 550                 555                 560 


Glu Arg Asp Ser Val Gly Gln Leu Gln Leu Tyr Arg His Pro Asp Arg 
                565                 570                 575     


Ser Gln Pro Ala Phe Leu Asp Ala Ile Asp Arg Arg Glu Asp Thr Phe 
            580                 585                 590         


Tyr Val Val Ser Phe Arg Arg Asp His Leu Leu Leu Pro Ala Ile Ser 
        595                 600                 605             


His Asn Lys Thr Ser Arg Pro Lys Met Ser Leu Val Met Pro Ala Met 
    610                 615                 620                 


Ala Pro Asn Glu Thr Leu Ser Gly Arg Gly Ala Pro Gly Asp Tyr Glu 
625                 630                 635                 640 


Glu Met Met Gln Ile Glu Cys Glu Val Met Asp Thr Arg Val Ile His 
                645                 650                 655     


Ile Lys Thr Ser Thr Val Pro Pro Ser Leu Arg Lys Gln Pro Ser Pro 
            660                 665                 670         


Thr Pro Gly Asn Ala Thr Gly Gly Pro Leu Pro Val Ser Ala Ala Ser 
        675                 680                 685             


Gln Ala His Gln Ala Ser His Gln Pro Leu Tyr Leu Asn His Pro 
    690                 695                 700             


<210>  667
<211>  6358
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (2)..(2233)

<400>  667
a atg att gaa gat agt ggg aaa aga gga aat acc atg gca gaa aga aga       49
  Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg         
  1               5                   10                  15              

cag ctg ttt gca gag atg agg gct caa gat ctg gat cgc atc cga ctc         97
Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu           
            20                  25                  30                    

tcc acc tac aga aca gca tgc aag ctt agg ttt gtt cag aag aaa tgc        145
Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val Gln Lys Lys Cys           
        35                  40                  45                        

aat ttg cac ctg gtg gac ata tgg aat gtc ata gaa gca ttg cgg gaa        193
Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu           
    50                  55                  60                            

aat gct ctg aac aac ctg gac cca aac act gaa ctc aac gtg tcc cgc        241
Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg           
65                  70                  75                  80            

tta gag gct gtg ctc tcc act att ttt tac cag ctc aac aaa cgg atg        289
Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met           
                85                  90                  95                

cca acc act cac caa atc cat gtg gag cag tcc atc agc ctc ctc ctt        337
Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu           
            100                 105                 110                   

aac ttc ctg ctt gca gcg ttt gat ccg gaa ggc cat ggt aaa att tca        385
Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser           
        115                 120                 125                       

gta ttt gct gtc aaa atg gct tta gcc aca ttg tgt gga ggg aag atc        433
Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile           
    130                 135                 140                           

atg gac aaa tta aga tat att ttc tca atg att tct gac tcc agt ggg        481
Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly           
145                 150                 155                 160           

gtg atg gtt tat gga cga tat gac caa ttc ctt cgg gaa gtt ctc aaa        529
Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys           
                165                 170                 175               

cta ccc acg gca gtt ttt gaa ggt cct tca ttt ggt tac aca gaa cag        577
Leu Pro Thr Ala Val Phe Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln           
            180                 185                 190                   

tca gcc aga tcc tgt ttc tcc caa cag aaa aaa gtc acg tta aat ggt        625
Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly           
        195                 200                 205                       

ttc ttg gac acg ctt atg tca gat cct ccc ccg cag tgt ctg gtc tgg        673
Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp           
    210                 215                 220                           

ttg cct ctt ctg cat cga cta gca aat gtg gaa aat gtc ttc cat ccg        721
Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro           
225                 230                 235                 240           

gtt gag tgt tcc tac tgc cac agt gag agt atg atg gga ttt cgc tac        769
Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr           
                245                 250                 255               

cga tgc caa cag tgt cac aat tac cag ctc tgt cag gac tgc ttc tgg        817
Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp           
            260                 265                 270                   

agg gga cat gcc ggt ggt tct cat agc aac cag cac caa atg aaa gag        865
Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu           
        275                 280                 285                       

tac acg tca tgg aaa tca cct gct aag aag ctg act aat gca tta agc        913
Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser           
    290                 295                 300                           

aag tcc ctg agc tgt gct tcc agc cgt gaa cct ttg cac ccc atg ttc        961
Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe           
305                 310                 315                 320           

cca gat cag cct gag aag cca ctc aac ttg gct cac atc gtt gat act       1009
Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Asp Thr           
                325                 330                 335               

tgg cct ccc aga cct gta acc agc atg aac gac acc ctg ttc tcc cac       1057
Trp Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His           
            340                 345                 350                   

tct gtt ccc tcc tca gga agt cct ttt att acc agg agc tct cct ccc       1105
Ser Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Ser Pro Pro           
        355                 360                 365                       

aag gac agt gaa gta gag cag aac aaa ctg ctg gct agg gct gct cca       1153
Lys Asp Ser Glu Val Glu Gln Asn Lys Leu Leu Ala Arg Ala Ala Pro           
    370                 375                 380                           

gct ttt ctg aag ggc aaa ggg ata cag tac agc ctg aat gtg gca gac       1201
Ala Phe Leu Lys Gly Lys Gly Ile Gln Tyr Ser Leu Asn Val Ala Asp           
385                 390                 395                 400           

agg cta gct gat gaa cat gtt ctc atc ggg ttg tat gtc aac atg ctc       1249
Arg Leu Ala Asp Glu His Val Leu Ile Gly Leu Tyr Val Asn Met Leu           
                405                 410                 415               

cgg aac aac ccc tca tgc atg ctt gag agt tca aac cgg ctt gat gaa       1297
Arg Asn Asn Pro Ser Cys Met Leu Glu Ser Ser Asn Arg Leu Asp Glu           
            420                 425                 430                   

gaa cac agg cta att gcc agg tat gcg gca agg ctg gca gca gag tcc       1345
Glu His Arg Leu Ile Ala Arg Tyr Ala Ala Arg Leu Ala Ala Glu Ser           
        435                 440                 445                       

tct tcg tct cag cca cct cag cag aga agt gct cct gac atc tct ttc       1393
Ser Ser Ser Gln Pro Pro Gln Gln Arg Ser Ala Pro Asp Ile Ser Phe           
    450                 455                 460                           

acc atc gat gcg aat aag cag caa agg cag ctg att gct gag cta gaa       1441
Thr Ile Asp Ala Asn Lys Gln Gln Arg Gln Leu Ile Ala Glu Leu Glu           
465                 470                 475                 480           

aac aag aac aga gaa atc tta cag gag atc cag aga ctt cgg cta gag       1489
Asn Lys Asn Arg Glu Ile Leu Gln Glu Ile Gln Arg Leu Arg Leu Glu           
                485                 490                 495               

cat gaa caa gct tct cag ccc acg cca gag aag gca cag caa aac ccc       1537
His Glu Gln Ala Ser Gln Pro Thr Pro Glu Lys Ala Gln Gln Asn Pro           
            500                 505                 510                   

acc ctg ctg gca gaa ctc cgg ctc ctc aga cag cgc aaa gat gag ctg       1585
Thr Leu Leu Ala Glu Leu Arg Leu Leu Arg Gln Arg Lys Asp Glu Leu           
        515                 520                 525                       

gaa cag aga atg tct gct ctc cag gag agc cgg aga gag cta atg gtc       1633
Glu Gln Arg Met Ser Ala Leu Gln Glu Ser Arg Arg Glu Leu Met Val           
    530                 535                 540                           

cag ttg gag ggt ctc atg aag cta cta aag act cag ggg gca ggc tct       1681
Gln Leu Glu Gly Leu Met Lys Leu Leu Lys Thr Gln Gly Ala Gly Ser           
545                 550                 555                 560           

ccc cgc tcc tcc ccc agc cac acc atc agc agg cca att ccc atg ccc       1729
Pro Arg Ser Ser Pro Ser His Thr Ile Ser Arg Pro Ile Pro Met Pro           
                565                 570                 575               

atc cgg tca gcg tca gcc tgc tcc acc ccg acg cac acg ccg cag gac       1777
Ile Arg Ser Ala Ser Ala Cys Ser Thr Pro Thr His Thr Pro Gln Asp           
            580                 585                 590                   

tcc ctc aca gga gta ggg gga gat gta caa gag gca ttt gca caa agt       1825
Ser Leu Thr Gly Val Gly Gly Asp Val Gln Glu Ala Phe Ala Gln Ser           
        595                 600                 605                       

tca aga aga aac tta agg aat gac ttg cta gtg gct gca gat tcc atc       1873
Ser Arg Arg Asn Leu Arg Asn Asp Leu Leu Val Ala Ala Asp Ser Ile           
    610                 615                 620                           

act aac act atg tcc tct ctt gtg aaa gag ctg aat tct gag gtt ggg       1921
Thr Asn Thr Met Ser Ser Leu Val Lys Glu Leu Asn Ser Glu Val Gly           
625                 630                 635                 640           

agt gaa aca gag agt aat gtg gat tct gaa ttt gca cgg act cag ttt       1969
Ser Glu Thr Glu Ser Asn Val Asp Ser Glu Phe Ala Arg Thr Gln Phe           
                645                 650                 655               

gag gat ctt gtt ccc tca cca acc tct gaa aag gct ttt cta gcg caa       2017
Glu Asp Leu Val Pro Ser Pro Thr Ser Glu Lys Ala Phe Leu Ala Gln           
            660                 665                 670                   

atc cat gcc cga aaa cct ggg tac att cac agt gga gct acc aca agt       2065
Ile His Ala Arg Lys Pro Gly Tyr Ile His Ser Gly Ala Thr Thr Ser           
        675                 680                 685                       

acc atg cgt ggc gac atg gtt acg gag gat gca gat ccc tat gtg cag       2113
Thr Met Arg Gly Asp Met Val Thr Glu Asp Ala Asp Pro Tyr Val Gln           
    690                 695                 700                           

cct gaa gat gaa aac tat gaa aat gac tct gtc cgg cag ctg gag aat       2161
Pro Glu Asp Glu Asn Tyr Glu Asn Asp Ser Val Arg Gln Leu Glu Asn           
705                 710                 715                 720           

gag ctc cag atg gag gaa tac ctg aaa cag aag ctg caa gat gaa gct       2209
Glu Leu Gln Met Glu Glu Tyr Leu Lys Gln Lys Leu Gln Asp Glu Ala           
                725                 730                 735               

tat cag gtc agc ttg caa ggt tga atgcaatatc cttttatcac actcctctca      2263
Tyr Gln Val Ser Leu Gln Gly                                               
            740                                                           

agcaagctat agtcagacag atgatgaaag taacatgaaa actggtgatg atggagagcc     2323

ctgtggccac acagaggagg aagacagcag cctggcagca gcctcaccga agagaggaac     2383

caccacaccc agcagctcct gacagacccc cacccctaaa gatgtgtcct gatgactata     2443

gtgcagctaa ctttttgttc tcagatttgt agtgcatagg tgtgtgtttc aagaaggaaa     2503

aaaaaagact tctgttcaaa gttaacttat cagctacatc ctctgtaacg tggttcatcc     2563

ctggttaaaa agcaaacaaa cacaggctga aaacccatgc tgctgttata cacaatggca     2623

gtattaacaa gcattttaaa cctttgcaca tgatattgaa cctgttcagt ttacaatgac     2683

aatattaata ctgtttatag ctagaagttt gatttctgaa ttctttgaga ttttagcaaa     2743

acagtttatt atacactgta catttttttc acagcaattg gaaaaaaaca accacttgca     2803

atcattcaat aaccctgaag aatttggttc ctgagtgtac aaactcagag cccggaagcc     2863

aagaagggtc cttggcctgc acggtctgta gttgactcca agtctctgtg agcagtgact     2923

tgaaccaaac acaccaggaa taatccattc tttggggcct ctttccaact cgaggttgtt     2983

ttctttcaag atactctaat cagccataga atttagtgta aatatttttt tttccaaata     3043

gatatcatat tcaaaaaagg cagcattcaa attatataga atctagtttt taaaatcagc     3103

acagatcttc ttaaaaactg tgaactatgt tttgaaatac tcgttactaa agctgtttat     3163

aaaccacagg tgccataaga tccccaaacg gactaaagtt atctctgctc ttccatggtc     3223

ttgttcctct cgttttggct ttaggaagca tgtctttaac agcaccgctc gttcacaagt     3283

tcccccatca agttgtttgg aggccttcag ctttaaatgt acaggcttaa agtgcgcttg     3343

caaacgtttg ctctcctttt tttctgaatg ttgattgcct tagctggcca cctggtgttc     3403

tgcatgtagc cttctgtggt catgtgaaag gagacaggct cttctaagtt gagttgggat     3463

ttttgcactc agtgaaaagc tgaagtgcaa aagagctatc aaagacaaga ggataaaaga     3523

ctgggatagt cttttccaag gaccctcttt agagggccct aaagacctcc tttgggaatt     3583

ctggggaaaa agaaaaagta atcttctact tgcttcaaga tttgattttt ttaaaaaagc     3643

ctgcgaccta ttcaatacat tatgcttaaa ttagcagttt ctctggaatt cctgtctctc     3703

ctttaaaaga aaggagagaa cattttagaa caatagttct caaagtgtgt tccccggaca     3763

agcagcatct gcaacactta ggaaggtctt cgaaatacta atttgtaagc cccacctcag     3823

gcctactgaa tcagaagctc tgggggttgg gtccagaagt ctgttttagt caaccctcta     3883

ggtgattctg atgctcgcta aaggttgaga actactgctt tagaatgaag tcgtataata     3943

aagtctctga aaaggcctta ttcagaataa gcaagaaagg ttctgtgatt cacttttgct     4003

tctggggctg gcaaaaacct tctctgaacc cacacaccaa gttcgtagtt ggtaggtgcc     4063

cagccaagtc ctgacatctt catgccccct ctgcagaggg cggctgtacg atgttcacat     4123

gtctgcgttt ggtcagacat catctccttg gctgcccttt gaaaccaaat cacttgcctt     4183

ggggataaag tgctcaattg gcattagtga gaagcccatc ctatcccttg acatacttaa     4243

tcatatatct ctccagagaa ctcacctgac aaatgtctct gagcacaggc tgacaccaaa     4303

gtggcacaac tgcacagttc tcagatttct ttgcacagat tgatttttat tgcgggtttt     4363

gttggggtgt cttaatgttc atctcttttc cactgcccat cctctgtgaa cccatacctc     4423

tctagatgga gcaggtggcc actggtgcct catactcagt attgaaaacc actacatccc     4483

agctacctat aatgctgtca gctcaaaatc atagccaggt agttcttgaa ctcagaactt     4543

aaatcctgca cgtggcactc caccactgac tggaccgagc tggcatatgt tgtttctttg     4603

tgtttctaca tcaaaatgtt cgtctaagat ttgaactgtt ctgctgataa ccttccccgt     4663

tgtcatagct atttcattgc caaccaactc catcacatgg ttgttgatat cgtcatataa     4723

agccattgca aggactctgg aaactgccgc caatgaccaa tttctgacta accagccacc     4783

ttttctctct cttagctcca cgtcagcact gagaccagac tcgagcaccc ctgtcctgta     4843

agcgagacaa aatggcgtgt gttattttgg ggttttgtgt tttttggtgg gtttctttcc     4903

ttggctctcc agatttactt ttggggcctg ttctaagtgc aaacccagca agtttcactt     4963

gtcctgtcca ttagatacaa ctacatcttg cgggggttgt ttctttcttg ttccacaatg     5023

aattgcacat ccatctccat cagagctgat agcctgttaa taagcactgg tctaacacag     5083

ccaaccctcc tccacagcgc catattaatg gaggagggga ggaaggtgaa atctactgca     5143

tgggattcag gaaacagttg tggttggtca ggacggaagt tggggtaagt ttggttggtc     5203

agagggagtt gtgctggaga ttgtgaaaaa tgggttcttg aatgatctac tataaggcag     5263

ggaaggttca tttgtaagta gtaatgtgaa ctgaattgca ttaagagtgt gtggcctttg     5323

ttgtgatata ctatgtattt tcttatatgc atgagccaaa ctgttgcatc ataatttagc     5383

actgatgtct gcttttattt tgatcatctt tgtccaccct tattagttct tggctgttaa     5443

ccgtagatag atcttgtaaa tccagcaacc tttggttgct gcattcccct tggttcgatt     5503

ccacgcaagg agccacaagt gagaactcca ctgtccttag aagaaagggc atttttactt     5563

ttgaaccaaa aagagaaaaa aaaatcagaa gtgttgcatc ttgaggcgaa ttaactgtaa     5623

gacattttta attatgacta ctgcaatttg acaccatttg aaataatcaa ttcagagaca     5683

ctaaagattt cacaatattc attggtattg taaaaaaaaa atactattgt atggattttt     5743

gtattgctgt taagtattgt tttgtgtgtg tgtgtgtgtg tgtgtgttgg aacctcctgg     5803

ggacatgtta tattttgaag tgattaaact atttaattgt gtgtctatat tttggagtgg     5863

aataatttct tcattaaaaa atgtttttaa aaacactata tcttgggtgg tttattcctt     5923

tgtttcagtg aatctttcct aaagcaacgt ggagtcagtc tgttgaaaga aggaaggcag     5983

gtacttgcag tttaaagcag gacccattga tggaatattg agccaccgag gcaaaatagc     6043

tcaccttctc ttgccttggg ggatgcatgg tttttaccat tctactgttt tattagcatc     6103

tgtgagcatc taatagaaat actattctgc tatttatgga aatccttatt ataattgata     6163

tggaagtgag tttgaaattc taacagctaa catatttcat gtttgtatca cacactgttc     6223

ttaacacttt atgtgacttc actcaattct ttgaatcctc tgcatctagc catgtattct     6283

gcaaatatta agtgctcaat ggtttttttg ttgaattact gaataaatga attagtggtg     6343

aaaaaaaaaa aaaaa                                                      6358


<210>  668
<211>  743
<212>  PRT
<213>  Homo sapiens

<400>  668

Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg 
1               5                   10                  15      


Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu 
            20                  25                  30          


Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val Gln Lys Lys Cys 
        35                  40                  45              


Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu 
    50                  55                  60                  


Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg 
65                  70                  75                  80  


Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met 
                85                  90                  95      


Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu 
            100                 105                 110         


Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser 
        115                 120                 125             


Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile 
    130                 135                 140                 


Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly 
145                 150                 155                 160 


Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys 
                165                 170                 175     


Leu Pro Thr Ala Val Phe Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln 
            180                 185                 190         


Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly 
        195                 200                 205             


Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp 
    210                 215                 220                 


Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro 
225                 230                 235                 240 


Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr 
                245                 250                 255     


Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp 
            260                 265                 270         


Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu 
        275                 280                 285             


Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser 
    290                 295                 300                 


Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe 
305                 310                 315                 320 


Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Asp Thr 
                325                 330                 335     


Trp Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His 
            340                 345                 350         


Ser Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Ser Pro Pro 
        355                 360                 365             


Lys Asp Ser Glu Val Glu Gln Asn Lys Leu Leu Ala Arg Ala Ala Pro 
    370                 375                 380                 


Ala Phe Leu Lys Gly Lys Gly Ile Gln Tyr Ser Leu Asn Val Ala Asp 
385                 390                 395                 400 


Arg Leu Ala Asp Glu His Val Leu Ile Gly Leu Tyr Val Asn Met Leu 
                405                 410                 415     


Arg Asn Asn Pro Ser Cys Met Leu Glu Ser Ser Asn Arg Leu Asp Glu 
            420                 425                 430         


Glu His Arg Leu Ile Ala Arg Tyr Ala Ala Arg Leu Ala Ala Glu Ser 
        435                 440                 445             


Ser Ser Ser Gln Pro Pro Gln Gln Arg Ser Ala Pro Asp Ile Ser Phe 
    450                 455                 460                 


Thr Ile Asp Ala Asn Lys Gln Gln Arg Gln Leu Ile Ala Glu Leu Glu 
465                 470                 475                 480 


Asn Lys Asn Arg Glu Ile Leu Gln Glu Ile Gln Arg Leu Arg Leu Glu 
                485                 490                 495     


His Glu Gln Ala Ser Gln Pro Thr Pro Glu Lys Ala Gln Gln Asn Pro 
            500                 505                 510         


Thr Leu Leu Ala Glu Leu Arg Leu Leu Arg Gln Arg Lys Asp Glu Leu 
        515                 520                 525             


Glu Gln Arg Met Ser Ala Leu Gln Glu Ser Arg Arg Glu Leu Met Val 
    530                 535                 540                 


Gln Leu Glu Gly Leu Met Lys Leu Leu Lys Thr Gln Gly Ala Gly Ser 
545                 550                 555                 560 


Pro Arg Ser Ser Pro Ser His Thr Ile Ser Arg Pro Ile Pro Met Pro 
                565                 570                 575     


Ile Arg Ser Ala Ser Ala Cys Ser Thr Pro Thr His Thr Pro Gln Asp 
            580                 585                 590         


Ser Leu Thr Gly Val Gly Gly Asp Val Gln Glu Ala Phe Ala Gln Ser 
        595                 600                 605             


Ser Arg Arg Asn Leu Arg Asn Asp Leu Leu Val Ala Ala Asp Ser Ile 
    610                 615                 620                 


Thr Asn Thr Met Ser Ser Leu Val Lys Glu Leu Asn Ser Glu Val Gly 
625                 630                 635                 640 


Ser Glu Thr Glu Ser Asn Val Asp Ser Glu Phe Ala Arg Thr Gln Phe 
                645                 650                 655     


Glu Asp Leu Val Pro Ser Pro Thr Ser Glu Lys Ala Phe Leu Ala Gln 
            660                 665                 670         


Ile His Ala Arg Lys Pro Gly Tyr Ile His Ser Gly Ala Thr Thr Ser 
        675                 680                 685             


Thr Met Arg Gly Asp Met Val Thr Glu Asp Ala Asp Pro Tyr Val Gln 
    690                 695                 700                 


Pro Glu Asp Glu Asn Tyr Glu Asn Asp Ser Val Arg Gln Leu Glu Asn 
705                 710                 715                 720 


Glu Leu Gln Met Glu Glu Tyr Leu Lys Gln Lys Leu Gln Asp Glu Ala 
                725                 730                 735     


Tyr Gln Val Ser Leu Gln Gly 
            740             


<210>  669
<211>  1844
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (187)..(1389)

<400>  669
ggagctactc agaagcggga gtctccgaga gaagaaaagc aggtggaagg agaggaagcg       60

gatgccgtgg ggtttacagc aggaaaatcc gtggagacag cagatccgag aagcggcgat      120

gtttgcgtag aaccctgtac gtgcttcctt cggcctgtcg ctcttccctt ctctctgacc      180

agcacc atg ctt ctc ctg gtg aca agc ctt ctg ctc tgt gag tta cca         228
       Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro            
       1               5                   10                             

cac cca gca ttc ctc ctg atc cca gag aaa tcg gat ctg cga aca gtg        276
His Pro Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val           
15                  20                  25                  30            

gca cca gcc tct agt ctc aat gtg agg ttt gac tcc agg acg atg aat        324
Ala Pro Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn           
                35                  40                  45                

tta agc tgg gac tgc caa gaa aac aca acc ttc agc aag tgt ttc tta        372
Leu Ser Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu           
            50                  55                  60                    

act gac aag aag aac aga gtc gtg gaa ccc agg ctc agt aac aac gaa        420
Thr Asp Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu           
        65                  70                  75                        

tgt tcg tgc aca ttt cgt gaa att tgt ctg cat gaa gga gtc aca ttt        468
Cys Ser Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe           
    80                  85                  90                            

gag gtt cac gtg aat act agt caa aga gga ttt caa cag aaa ctg ctt        516
Glu Val His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu           
95                  100                 105                 110           

tat cca aat tca gga agg gag ggt acc gct gct cag aat ttc tcc tgt        564
Tyr Pro Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys           
                115                 120                 125               

ttc atc tac aat gcg gat tta atg aac tgt acc tgg gcg agg ggt ccg        612
Phe Ile Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro           
            130                 135                 140                   

acg gcc ccc cgt gac gtc cag tat ttt ttg tac ata cga aac tca aag        660
Thr Ala Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys           
        145                 150                 155                       

aga agg agg gag atc cgg tgt cct tat tac ata caa gac tca gga acc        708
Arg Arg Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr           
    160                 165                 170                           

cat gtg gga tgt cac ctg gat aac ctg tca gga tta acg tct cgc aat        756
His Val Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn           
175                 180                 185                 190           

tac ttt ctg gtt aac gga acc agc cga gaa att ggc atc caa ttc ttt        804
Tyr Phe Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe           
                195                 200                 205               

gat tca ctt ttg gac aca aag aaa ata gaa cga ttc aac cct ccc agc        852
Asp Ser Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser           
            210                 215                 220                   

aat gtc acc gta cgt tgc aac acg acg cac tgc ctc gta cgg tgg aaa        900
Asn Val Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys           
        225                 230                 235                       

cag ccc agg acc tat cag aag ctg tcg tac ctg gac ttt cag tac cag        948
Gln Pro Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln           
    240                 245                 250                           

ctg gac gtc cac aga aag aat acc cag cct ggc acg gaa aac cta ctg        996
Leu Asp Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu           
255                 260                 265                 270           

att aat gtt tct ggt gat ttg gaa aat aga tac aac ttt cca agc tct       1044
Ile Asn Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser           
                275                 280                 285               

gag ccc aga gca aaa cac agt gtg aag atc aga gct gca gac gtc cgc       1092
Glu Pro Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg           
            290                 295                 300                   

atc ttg aat tgg agc tcc tgg agt gaa gcc att gaa ttt ggt tct gac       1140
Ile Leu Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp           
        305                 310                 315                       

gac ggg aac ctc ggc tct gtg tac att tat gtg ctc cta atc gtg gga       1188
Asp Gly Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly           
    320                 325                 330                           

acc ctt gtc tgt ggc atc gtc ctc ggc ttc ctc ttt aaa agg ttc ctt       1236
Thr Leu Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu           
335                 340                 345                 350           

agg ata cag cgg ctg ttc ccg cca gtt cca cag atc aaa gac aaa ctg       1284
Arg Ile Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu           
                355                 360                 365               

aat gat aac cat gag gtg gaa gac gag atc atc tgg gag gaa ttc acc       1332
Asn Asp Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Thr           
            370                 375                 380                   

cca gag gaa ggg aaa ggc tac cgc gaa gag gtc ttg acc gtg aag gaa       1380
Pro Glu Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Thr Val Lys Glu           
        385                 390                 395                       

att acc tga gacccagagg gtgtaggaat ggcatggaca tctccgcctc               1429
Ile Thr                                                                   
    400                                                                   

cgcgacacgg gggaactgtt ttcttgatga tgctgtgaac ctttatatca ttttctatgt     1489

ttttatttaa aaacatgaca tttggggcca ggcgcggtgg ctcacgcctg taatcccagc     1549

actttgggag gccaaggcag gcggatcacc tgaggtcagg agttcaagac cagcctgccc     1609

aacatggtga aaccccatct ggactaaaaa tgcagaaatt tacccaggca cggcggcgga     1669

cgcccatcat cccagctact tgggaggctg aggcaggaga attgcttgaa cccgtgaggc     1729

ggaggttgta gtgagccaag atcgcaccat tgcacaccaa cctgggtgac agagcaagat     1789

tgcatctcaa aacaaacaat aataataaat aataaaaacc tgatatttgg ctggg          1844


<210>  670
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  670

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly 
305                 310                 315                 320 


Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu 
                325                 330                 335     


Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile 
            340                 345                 350         


Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp 
        355                 360                 365             


Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Thr Pro Glu 
    370                 375                 380                 


Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Thr Val Lys Glu Ile Thr 
385                 390                 395                 400 


<210>  671
<211>  7544
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (56)..(6265)

<400>  671
gcggccgggc cgggccgcgg gagcaggcgg aggcggaggc ggcgggggca ggagg atg        58
                                                             Met          
                                                             1            

tcg cag ccg ccg ctg ctc ccc gcc tcg gcg gag act cgg aag ttc acc        106
Ser Gln Pro Pro Leu Leu Pro Ala Ser Ala Glu Thr Arg Lys Phe Thr           
            5                   10                  15                    

cgg gcg ctg agt aag ccg ggc acg gcg gcc gag ctg cgg cag agc gtg        154
Arg Ala Leu Ser Lys Pro Gly Thr Ala Ala Glu Leu Arg Gln Ser Val           
        20                  25                  30                        

tct gag gtg gtg cgc ggc tcc gtg ctc ctg gca aag cca aag cta att        202
Ser Glu Val Val Arg Gly Ser Val Leu Leu Ala Lys Pro Lys Leu Ile           
    35                  40                  45                            

gag cca ctc gac tat gaa aat gtc atc gtc cag aag aag act cag atc        250
Glu Pro Leu Asp Tyr Glu Asn Val Ile Val Gln Lys Lys Thr Gln Ile           
50                  55                  60                  65            

ctg aac gac tgt tta cgg gag atg ctg ctc ttc cct tac gat gac ttt        298
Leu Asn Asp Cys Leu Arg Glu Met Leu Leu Phe Pro Tyr Asp Asp Phe           
                70                  75                  80                

cag acg gcc atc ctg aga cga cag ggt cga tac ata tgc tca aca gtg        346
Gln Thr Ala Ile Leu Arg Arg Gln Gly Arg Tyr Ile Cys Ser Thr Val           
            85                  90                  95                    

cct gcg aag gcg gaa gag gaa gca cag agc ttg ttt gtt aca gag tgc        394
Pro Ala Lys Ala Glu Glu Glu Ala Gln Ser Leu Phe Val Thr Glu Cys           
        100                 105                 110                       

atc aaa acc tat aac tct gac tgg cat ctt gtg aac tat aaa tat gaa        442
Ile Lys Thr Tyr Asn Ser Asp Trp His Leu Val Asn Tyr Lys Tyr Glu           
    115                 120                 125                           

gat tac tca gga gag ttt cga cag ctt ccg aac aaa gtg gtc aag ttg        490
Asp Tyr Ser Gly Glu Phe Arg Gln Leu Pro Asn Lys Val Val Lys Leu           
130                 135                 140                 145           

gat aaa ctt cca gtt cat gtc tat gaa gtt gac gag gag gtc gac aaa        538
Asp Lys Leu Pro Val His Val Tyr Glu Val Asp Glu Glu Val Asp Lys           
                150                 155                 160               

gat gag gat gct gcc tcc ctt ggt tcc cag aag ggt ggg atc acc aag        586
Asp Glu Asp Ala Ala Ser Leu Gly Ser Gln Lys Gly Gly Ile Thr Lys           
            165                 170                 175                   

cat ggc tgg ctg tac aaa ggc aac atg aac agt gcc atc agc gtg acc        634
His Gly Trp Leu Tyr Lys Gly Asn Met Asn Ser Ala Ile Ser Val Thr           
        180                 185                 190                       

atg agg tca ttt aag aga cga ttt ttc cac ctg att caa ctt ggc gat        682
Met Arg Ser Phe Lys Arg Arg Phe Phe His Leu Ile Gln Leu Gly Asp           
    195                 200                 205                           

gga tcc tat aat ttg aat ttt tat aaa gat gaa aag atc tcc aaa gaa        730
Gly Ser Tyr Asn Leu Asn Phe Tyr Lys Asp Glu Lys Ile Ser Lys Glu           
210                 215                 220                 225           

cca aaa gga tca ata ttt ctg gat tcc tgt atg ggt gtc gtt cag aac        778
Pro Lys Gly Ser Ile Phe Leu Asp Ser Cys Met Gly Val Val Gln Asn           
                230                 235                 240               

aac aaa gtc agg cgt ttt gct ttt gag ctc aag atg cag gac aaa agt        826
Asn Lys Val Arg Arg Phe Ala Phe Glu Leu Lys Met Gln Asp Lys Ser           
            245                 250                 255                   

agt tat ctc ttg gca gca gac agt gaa gtg gaa atg gaa gaa tgg atc        874
Ser Tyr Leu Leu Ala Ala Asp Ser Glu Val Glu Met Glu Glu Trp Ile           
        260                 265                 270                       

aca att cta aat aag atc ctc cag ctc aac ttt gaa gct gca atg caa        922
Thr Ile Leu Asn Lys Ile Leu Gln Leu Asn Phe Glu Ala Ala Met Gln           
    275                 280                 285                           

gaa aag cga aat ggc gac tct cac gaa gat gat gaa caa agc aaa ttg        970
Glu Lys Arg Asn Gly Asp Ser His Glu Asp Asp Glu Gln Ser Lys Leu           
290                 295                 300                 305           

gaa ggt tct ggt tcc ggt tta gat agc tac ctg ccg gaa ctt gcc aag       1018
Glu Gly Ser Gly Ser Gly Leu Asp Ser Tyr Leu Pro Glu Leu Ala Lys           
                310                 315                 320               

agt gca aga gaa gca gaa atc aaa ctg aaa agt gaa agc aga gtc aaa       1066
Ser Ala Arg Glu Ala Glu Ile Lys Leu Lys Ser Glu Ser Arg Val Lys           
            325                 330                 335                   

ctt ttt tat ttg gac cca gat gcc cag aag ctt gac ttc tca tca gct       1114
Leu Phe Tyr Leu Asp Pro Asp Ala Gln Lys Leu Asp Phe Ser Ser Ala           
        340                 345                 350                       

gag cca gaa gtg aag tca ttt gaa gag aag ttt gga aaa agg atc ctt       1162
Glu Pro Glu Val Lys Ser Phe Glu Glu Lys Phe Gly Lys Arg Ile Leu           
    355                 360                 365                           

gtc aag tgc aat gat tta tct ttc aat ttg caa tgc tgt gtt gcc gaa       1210
Val Lys Cys Asn Asp Leu Ser Phe Asn Leu Gln Cys Cys Val Ala Glu           
370                 375                 380                 385           

aat gaa gaa gga ccc act aca aat gtt gaa cct ttc ttt gtt act cta       1258
Asn Glu Glu Gly Pro Thr Thr Asn Val Glu Pro Phe Phe Val Thr Leu           
                390                 395                 400               

tcc ctg ttt gac ata aaa tac aac cgg aag att tct gcc gat ttc cac       1306
Ser Leu Phe Asp Ile Lys Tyr Asn Arg Lys Ile Ser Ala Asp Phe His           
            405                 410                 415                   

gta gac ctg aac cat ttc tca gtg agg caa atg ctc gcc acc acg tcc       1354
Val Asp Leu Asn His Phe Ser Val Arg Gln Met Leu Ala Thr Thr Ser           
        420                 425                 430                       

ccg gcg ctg atg aat ggc agt ggg cag agc cca tct gtc ctc aag ggc       1402
Pro Ala Leu Met Asn Gly Ser Gly Gln Ser Pro Ser Val Leu Lys Gly           
    435                 440                 445                           

atc ctt cat gaa gcc gcc atg cag tat ccg aag cag gga ata ttt tca       1450
Ile Leu His Glu Ala Ala Met Gln Tyr Pro Lys Gln Gly Ile Phe Ser           
450                 455                 460                 465           

gtc act tgt cct cat cca gat ata ttt ctt gtg gcc aga att gaa aaa       1498
Val Thr Cys Pro His Pro Asp Ile Phe Leu Val Ala Arg Ile Glu Lys           
                470                 475                 480               

gtc ctt cag ggg agc atc aca cat tgc gct gag cca tat atg aaa agt       1546
Val Leu Gln Gly Ser Ile Thr His Cys Ala Glu Pro Tyr Met Lys Ser           
            485                 490                 495                   

tca gac tct tct aag gtg gcc cag aag gtg ctg aag aat gcc aag cag       1594
Ser Asp Ser Ser Lys Val Ala Gln Lys Val Leu Lys Asn Ala Lys Gln           
        500                 505                 510                       

gca tgc caa aga cta gga cag tat aga atg cca ttt gct tgg gca gca       1642
Ala Cys Gln Arg Leu Gly Gln Tyr Arg Met Pro Phe Ala Trp Ala Ala           
    515                 520                 525                           

agg aca ttg ttt aag gat gca tct gga aat ctt gac aaa aat gcc aga       1690
Arg Thr Leu Phe Lys Asp Ala Ser Gly Asn Leu Asp Lys Asn Ala Arg           
530                 535                 540                 545           

ttt tct gcc atc tac agg caa gac agc aat aag cta tcc aat gat gac       1738
Phe Ser Ala Ile Tyr Arg Gln Asp Ser Asn Lys Leu Ser Asn Asp Asp           
                550                 555                 560               

atg ctc aag tta ctt gca gac ttt cgg aaa cct gag aag atg gct aag       1786
Met Leu Lys Leu Leu Ala Asp Phe Arg Lys Pro Glu Lys Met Ala Lys           
            565                 570                 575                   

ctc cca gtg att tta ggc aat cta gac att aca att gat aat gtt tcc       1834
Leu Pro Val Ile Leu Gly Asn Leu Asp Ile Thr Ile Asp Asn Val Ser           
        580                 585                 590                       

tca gac ttc cct aat tat gtt aat tca tca tac att ccc aca aaa caa       1882
Ser Asp Phe Pro Asn Tyr Val Asn Ser Ser Tyr Ile Pro Thr Lys Gln           
    595                 600                 605                           

ttt gaa acc tgc agt aaa act ccc atc acg ttt gaa gtg gag gaa ttt       1930
Phe Glu Thr Cys Ser Lys Thr Pro Ile Thr Phe Glu Val Glu Glu Phe           
610                 615                 620                 625           

gtg ccc tgc ata cca aaa cac act cag cct tac acc atc tac acc aat       1978
Val Pro Cys Ile Pro Lys His Thr Gln Pro Tyr Thr Ile Tyr Thr Asn           
                630                 635                 640               

cac ctt tac gtt tat cct aag tac ttg aaa tac gac agt cag aag tct       2026
His Leu Tyr Val Tyr Pro Lys Tyr Leu Lys Tyr Asp Ser Gln Lys Ser           
            645                 650                 655                   

ttt gcc aag gct aga aat att gcg att tgc att gaa ttc aaa gat tca       2074
Phe Ala Lys Ala Arg Asn Ile Ala Ile Cys Ile Glu Phe Lys Asp Ser           
        660                 665                 670                       

gat gag gaa gac tct cag ccc ctt aag tgc att tat ggc aga cct ggt       2122
Asp Glu Glu Asp Ser Gln Pro Leu Lys Cys Ile Tyr Gly Arg Pro Gly           
    675                 680                 685                           

ggg cca gtt ttc aca aga agc gcc ttt gct gca gtt tta cac cat cac       2170
Gly Pro Val Phe Thr Arg Ser Ala Phe Ala Ala Val Leu His His His           
690                 695                 700                 705           

caa aac cca gaa ttt tat gat gag att aaa ata gag ttg ccc act cag       2218
Gln Asn Pro Glu Phe Tyr Asp Glu Ile Lys Ile Glu Leu Pro Thr Gln           
                710                 715                 720               

ctg cat gaa aag cac cac ctg ttg ctc aca ttc ttc cat gtc agc tgt       2266
Leu His Glu Lys His His Leu Leu Leu Thr Phe Phe His Val Ser Cys           
            725                 730                 735                   

gac aac tca agt aaa gga agc acg aag aag agg gat gtc gtt gaa acc       2314
Asp Asn Ser Ser Lys Gly Ser Thr Lys Lys Arg Asp Val Val Glu Thr           
        740                 745                 750                       

caa gtt ggc tac tcc tgg ctt ccc ctc ctg aaa gac gga agg gtg gtg       2362
Gln Val Gly Tyr Ser Trp Leu Pro Leu Leu Lys Asp Gly Arg Val Val           
    755                 760                 765                           

aca agc gag cag cac atc ccg gtc tcg gcg aac ctt cct tcg ggc tat       2410
Thr Ser Glu Gln His Ile Pro Val Ser Ala Asn Leu Pro Ser Gly Tyr           
770                 775                 780                 785           

ctt ggc tac cag gag ctt ggg atg ggc agg cat tat ggt ccg gaa att       2458
Leu Gly Tyr Gln Glu Leu Gly Met Gly Arg His Tyr Gly Pro Glu Ile           
                790                 795                 800               

aaa tgg gta gat gga ggc aag cca ctg ctg aaa att tcc act cat ctg       2506
Lys Trp Val Asp Gly Gly Lys Pro Leu Leu Lys Ile Ser Thr His Leu           
            805                 810                 815                   

gtt tct aca gtg tat act cag gat cag cat tta cat aat ttt ttc cag       2554
Val Ser Thr Val Tyr Thr Gln Asp Gln His Leu His Asn Phe Phe Gln           
        820                 825                 830                       

tac tgt cag aaa acc gaa tct gga gcc caa gcc tta gga aac gaa ctt       2602
Tyr Cys Gln Lys Thr Glu Ser Gly Ala Gln Ala Leu Gly Asn Glu Leu           
    835                 840                 845                           

gta aag tac ctt aag agt ctg cat gcg atg gaa ggc cac gtg atg atc       2650
Val Lys Tyr Leu Lys Ser Leu His Ala Met Glu Gly His Val Met Ile           
850                 855                 860                 865           

gcc ttc ttg ccc act atc cta aac cag ctg ttc cga gtc ctc acc aga       2698
Ala Phe Leu Pro Thr Ile Leu Asn Gln Leu Phe Arg Val Leu Thr Arg           
                870                 875                 880               

gcc aca cag gaa gaa gtc gcg gtt aac gtg act cgg gtc att att cat       2746
Ala Thr Gln Glu Glu Val Ala Val Asn Val Thr Arg Val Ile Ile His           
            885                 890                 895                   

gtg gtt gcc cag tgc cat gag gaa gga ttg gag agc cac ttg agg tca       2794
Val Val Ala Gln Cys His Glu Glu Gly Leu Glu Ser His Leu Arg Ser           
        900                 905                 910                       

tat gtt aag tac gcg tat aag gct gag cca tat gtt gcc tct gaa tac       2842
Tyr Val Lys Tyr Ala Tyr Lys Ala Glu Pro Tyr Val Ala Ser Glu Tyr           
    915                 920                 925                           

aag aca gtg cat gaa gaa ctg acc aaa tcc atg acc acg att ctc aag       2890
Lys Thr Val His Glu Glu Leu Thr Lys Ser Met Thr Thr Ile Leu Lys           
930                 935                 940                 945           

cct tct gcc gat ttc ctc acc agc aac aaa cta ctg aag tac tca tgg       2938
Pro Ser Ala Asp Phe Leu Thr Ser Asn Lys Leu Leu Lys Tyr Ser Trp           
                950                 955                 960               

ttt ttc ttt gat gta ctg atc aaa tct atg gct cag cat ttg ata gag       2986
Phe Phe Phe Asp Val Leu Ile Lys Ser Met Ala Gln His Leu Ile Glu           
            965                 970                 975                   

aac tcc aaa gtt aag ttg ctg cga aac cag aga ttt cct gca tcc tat       3034
Asn Ser Lys Val Lys Leu Leu Arg Asn Gln Arg Phe Pro Ala Ser Tyr           
        980                 985                 990                       

cat cat gca gtg gaa acc gtt  gta aat atg ctg atg  cca cac atc act     3082
His His Ala Val Glu Thr Val  Val Asn Met Leu Met  Pro His Ile Thr         
    995                 1000                 1005                         

cag  aag ttt cga gat aat  cca gag gca tct aag  aac gcg aat cat        3127
Gln  Lys Phe Arg Asp Asn  Pro Glu Ala Ser Lys  Asn Ala Asn His            
1010                 1015                 1020                            

agc  ctt gct gtc ttc atc  aag aga tgt ttc acc  ttc atg gac agg        3172
Ser  Leu Ala Val Phe Ile  Lys Arg Cys Phe Thr  Phe Met Asp Arg            
1025                 1030                 1035                            

ggc  ttt gtc ttc aag cag  atc aac aac tac att  agc tgt ttt gct        3217
Gly  Phe Val Phe Lys Gln  Ile Asn Asn Tyr Ile  Ser Cys Phe Ala            
1040                 1045                 1050                            

cct  gga gac cca aag acc  ctc ttt gaa tac aag  ttt gaa ttt ctc        3262
Pro  Gly Asp Pro Lys Thr  Leu Phe Glu Tyr Lys  Phe Glu Phe Leu            
1055                 1060                 1065                            

cgt  gta gtg tgc aac cat  gaa cat tat att ccg  ttg aac tta cca        3307
Arg  Val Val Cys Asn His  Glu His Tyr Ile Pro  Leu Asn Leu Pro            
1070                 1075                 1080                            

atg  cca ttt gga aaa ggc  agg att caa aga tac  caa gac ctc cag        3352
Met  Pro Phe Gly Lys Gly  Arg Ile Gln Arg Tyr  Gln Asp Leu Gln            
1085                 1090                 1095                            

ctt  gac tac tca tta aca  gat gag ttc tgc aga  aac cac ttc ttg        3397
Leu  Asp Tyr Ser Leu Thr  Asp Glu Phe Cys Arg  Asn His Phe Leu            
1100                 1105                 1110                            

gtg  gga ctg tta ctg agg  gag gtg ggg aca gcc  ctc cag gag ttc        3442
Val  Gly Leu Leu Leu Arg  Glu Val Gly Thr Ala  Leu Gln Glu Phe            
1115                 1120                 1125                            

cgg  gag gtc cgt ctg atc  gcc atc agt gtg ctc  aag aac ctg ctg        3487
Arg  Glu Val Arg Leu Ile  Ala Ile Ser Val Leu  Lys Asn Leu Leu            
1130                 1135                 1140                            

ata  aag cat tct ttt gat  gac aga tat gct tca  agg agc cat cag        3532
Ile  Lys His Ser Phe Asp  Asp Arg Tyr Ala Ser  Arg Ser His Gln            
1145                 1150                 1155                            

gca  agg ata gcc acc ctc  tac ctg cct ctg ttt  ggt ctg ctg att        3577
Ala  Arg Ile Ala Thr Leu  Tyr Leu Pro Leu Phe  Gly Leu Leu Ile            
1160                 1165                 1170                            

gaa  aac gtc cag cgg atc  aat gtg agg gat gtg  tca ccc ttc cct        3622
Glu  Asn Val Gln Arg Ile  Asn Val Arg Asp Val  Ser Pro Phe Pro            
1175                 1180                 1185                            

gtg  aac gcg ggc atg act  gtg aag gat gaa tcc  ctg gct cta cca        3667
Val  Asn Ala Gly Met Thr  Val Lys Asp Glu Ser  Leu Ala Leu Pro            
1190                 1195                 1200                            

gct  gtg aat ccg ctg gtg  acg ccg cag aag gga  agc acc ctg gac        3712
Ala  Val Asn Pro Leu Val  Thr Pro Gln Lys Gly  Ser Thr Leu Asp            
1205                 1210                 1215                            

aac  agc ctg cac aag gac  ctg ctg ggc gcc atc  tcc ggc att gct        3757
Asn  Ser Leu His Lys Asp  Leu Leu Gly Ala Ile  Ser Gly Ile Ala            
1220                 1225                 1230                            

tct  cca tat aca acc tca  act cca aac atc aac  agt gtg aga aat        3802
Ser  Pro Tyr Thr Thr Ser  Thr Pro Asn Ile Asn  Ser Val Arg Asn            
1235                 1240                 1245                            

gct  gat tcg aga gga tct  ctc ata agc aca gat  tcg ggt aac agc        3847
Ala  Asp Ser Arg Gly Ser  Leu Ile Ser Thr Asp  Ser Gly Asn Ser            
1250                 1255                 1260                            

ctt  cca gaa agg aat agt  gag aag agc aat tcc  ctg gat aag cac        3892
Leu  Pro Glu Arg Asn Ser  Glu Lys Ser Asn Ser  Leu Asp Lys His            
1265                 1270                 1275                            

caa  caa agt agc aca ttg  gga aat tcc gtg gtt  cgc tgt gat aaa        3937
Gln  Gln Ser Ser Thr Leu  Gly Asn Ser Val Val  Arg Cys Asp Lys            
1280                 1285                 1290                            

ctt  gac cag tct gag att  aag agc cta ctg atg  tgt ttc ctc tac        3982
Leu  Asp Gln Ser Glu Ile  Lys Ser Leu Leu Met  Cys Phe Leu Tyr            
1295                 1300                 1305                            

atc  tta aag agc atg tct  gat gat gct ttg ttt  aca tat tgg aac        4027
Ile  Leu Lys Ser Met Ser  Asp Asp Ala Leu Phe  Thr Tyr Trp Asn            
1310                 1315                 1320                            

aag  gct tca aca tct gaa  ctt atg gat ttt ttt  aca ata tct gaa        4072
Lys  Ala Ser Thr Ser Glu  Leu Met Asp Phe Phe  Thr Ile Ser Glu            
1325                 1330                 1335                            

gtc  tgc ctg cac cag ttc  cag tac atg ggg aag  cga tac ata gcc        4117
Val  Cys Leu His Gln Phe  Gln Tyr Met Gly Lys  Arg Tyr Ile Ala            
1340                 1345                 1350                            

aga  aca gga atg atg cat  gcc aga ttg cag cag  ctg ggc agc ctg        4162
Arg  Thr Gly Met Met His  Ala Arg Leu Gln Gln  Leu Gly Ser Leu            
1355                 1360                 1365                            

gat  aac tct ctc act ttt  aac cac agc tat ggc  cac tcg gac gca        4207
Asp  Asn Ser Leu Thr Phe  Asn His Ser Tyr Gly  His Ser Asp Ala            
1370                 1375                 1380                            

gat  gtt ctg cac cag tca  tta ctt gaa gcc aac  att gct act gag        4252
Asp  Val Leu His Gln Ser  Leu Leu Glu Ala Asn  Ile Ala Thr Glu            
1385                 1390                 1395                            

gtt  tgc ctg aca gct ctg  gac acg ctt tct cta  ttt aca ttg gcg        4297
Val  Cys Leu Thr Ala Leu  Asp Thr Leu Ser Leu  Phe Thr Leu Ala            
1400                 1405                 1410                            

ttt  aag aac cag ctc ctg  gcc gac cat gga cat  aat cct ctc atg        4342
Phe  Lys Asn Gln Leu Leu  Ala Asp His Gly His  Asn Pro Leu Met            
1415                 1420                 1425                            

aaa  aaa gtt ttt gat gtc  tac ctg tgt ttt ctt  caa aaa cat cag        4387
Lys  Lys Val Phe Asp Val  Tyr Leu Cys Phe Leu  Gln Lys His Gln            
1430                 1435                 1440                            

tct  gaa acg gct tta aaa  aat gtc ttc act gcc  tta agg tcc tta        4432
Ser  Glu Thr Ala Leu Lys  Asn Val Phe Thr Ala  Leu Arg Ser Leu            
1445                 1450                 1455                            

att  tat aag ttt ccc tca  aca ttc tat gaa ggg  aga gcg gac atg        4477
Ile  Tyr Lys Phe Pro Ser  Thr Phe Tyr Glu Gly  Arg Ala Asp Met            
1460                 1465                 1470                            

tgt  gcg gct ctg tgt tac  gag att ctc aag tgc  tgt aac tcc aag        4522
Cys  Ala Ala Leu Cys Tyr  Glu Ile Leu Lys Cys  Cys Asn Ser Lys            
1475                 1480                 1485                            

ctg  agc tcc atc agg acg  gag gcc tcc cag ctg  ctc tac ttc ctg        4567
Leu  Ser Ser Ile Arg Thr  Glu Ala Ser Gln Leu  Leu Tyr Phe Leu            
1490                 1495                 1500                            

atg  agg aac aac ttt gat  tac act gga aag aag  tcc ttt gtc cgg        4612
Met  Arg Asn Asn Phe Asp  Tyr Thr Gly Lys Lys  Ser Phe Val Arg            
1505                 1510                 1515                            

aca  cat ttg caa gtc atc  ata tct gtc agc cag  ctg ata gca gac        4657
Thr  His Leu Gln Val Ile  Ile Ser Val Ser Gln  Leu Ile Ala Asp            
1520                 1525                 1530                            

gtt  gtt ggc att ggg gga  acc aga ttc cag cag  tcc ctg tcc atc        4702
Val  Val Gly Ile Gly Gly  Thr Arg Phe Gln Gln  Ser Leu Ser Ile            
1535                 1540                 1545                            

atc  aac aac tgt gcc aac  agt gac cgg ctt att  aag cac acc agc        4747
Ile  Asn Asn Cys Ala Asn  Ser Asp Arg Leu Ile  Lys His Thr Ser            
1550                 1555                 1560                            

ttc  tcc tct gat gtg aag  gac tta acc aaa agg  ata cgc acg gtg        4792
Phe  Ser Ser Asp Val Lys  Asp Leu Thr Lys Arg  Ile Arg Thr Val            
1565                 1570                 1575                            

cta  atg gcc acc gcc cag  atg aag gag cat gag  aac gac cca gag        4837
Leu  Met Ala Thr Ala Gln  Met Lys Glu His Glu  Asn Asp Pro Glu            
1580                 1585                 1590                            

atg  ctg gtg gac ctc cag  tac agc ctg gcc aaa  tcc tat gcc agc        4882
Met  Leu Val Asp Leu Gln  Tyr Ser Leu Ala Lys  Ser Tyr Ala Ser            
1595                 1600                 1605                            

acg  ccc gag ctc agg aag  acg tgg ctc gac agc  atg gcc agg atc        4927
Thr  Pro Glu Leu Arg Lys  Thr Trp Leu Asp Ser  Met Ala Arg Ile            
1610                 1615                 1620                            

cat  gtc aaa aat ggc gat  ctc tca gag gca gca  atg tgc tat gtc        4972
His  Val Lys Asn Gly Asp  Leu Ser Glu Ala Ala  Met Cys Tyr Val            
1625                 1630                 1635                            

cac  gta aca gcc cta gtg  gca gaa tat ctc aca  cgg aaa gaa gca        5017
His  Val Thr Ala Leu Val  Ala Glu Tyr Leu Thr  Arg Lys Glu Ala            
1640                 1645                 1650                            

gtc  cag tgg gag ccg ccc  ctt ctc ccc cac agc  cat agc gcc tgc        5062
Val  Gln Trp Glu Pro Pro  Leu Leu Pro His Ser  His Ser Ala Cys            
1655                 1660                 1665                            

ctg  agg agg agc cgg gga  ggc gtg ttt aga caa  gga tgc acc gcc        5107
Leu  Arg Arg Ser Arg Gly  Gly Val Phe Arg Gln  Gly Cys Thr Ala            
1670                 1675                 1680                            

ttc  agg gtc att acc cca  aac atc gac gag gag  gcc tcc atg atg        5152
Phe  Arg Val Ile Thr Pro  Asn Ile Asp Glu Glu  Ala Ser Met Met            
1685                 1690                 1695                            

gaa  gac gtg ggg atg cag  gat gtc cat ttc aac  gag gat gtg ctg        5197
Glu  Asp Val Gly Met Gln  Asp Val His Phe Asn  Glu Asp Val Leu            
1700                 1705                 1710                            

atg  gag ctc ctt gag cag  tgc gca gat gga ctc  tgg aaa gcc gag        5242
Met  Glu Leu Leu Glu Gln  Cys Ala Asp Gly Leu  Trp Lys Ala Glu            
1715                 1720                 1725                            

cgc  tac gag ctc atc gcc  gac atc tac aaa ctt  atc atc ccc att        5287
Arg  Tyr Glu Leu Ile Ala  Asp Ile Tyr Lys Leu  Ile Ile Pro Ile            
1730                 1735                 1740                            

tat  gag aag cgg agg gat  ttt gag agg ctg gcc  cat ctg tat gac        5332
Tyr  Glu Lys Arg Arg Asp  Phe Glu Arg Leu Ala  His Leu Tyr Asp            
1745                 1750                 1755                            

acg  ctg cac cgg gcc tac  agc aaa gtg acc gag  gtc atg cac tcg        5377
Thr  Leu His Arg Ala Tyr  Ser Lys Val Thr Glu  Val Met His Ser            
1760                 1765                 1770                            

ggc  cgc agg ctt ctg ggg  acc tac ttc cgg gta  gcc ttc ttc ggg        5422
Gly  Arg Arg Leu Leu Gly  Thr Tyr Phe Arg Val  Ala Phe Phe Gly            
1775                 1780                 1785                            

cag  gca gcg caa tac cag  ttt aca gac agt gaa  aca gat gtg gag        5467
Gln  Ala Ala Gln Tyr Gln  Phe Thr Asp Ser Glu  Thr Asp Val Glu            
1790                 1795                 1800                            

gga  ttc ttt gaa gat gaa  gat gga aag gag tat  att tac aag gaa        5512
Gly  Phe Phe Glu Asp Glu  Asp Gly Lys Glu Tyr  Ile Tyr Lys Glu            
1805                 1810                 1815                            

ccc  aaa ctc aca ccg ctg  tcg gaa att tct cag  aga ctc ctt aaa        5557
Pro  Lys Leu Thr Pro Leu  Ser Glu Ile Ser Gln  Arg Leu Leu Lys            
1820                 1825                 1830                            

ctg  tac tcg gat aaa ttt  ggt tct gaa aat gtc  aaa atg ata cag        5602
Leu  Tyr Ser Asp Lys Phe  Gly Ser Glu Asn Val  Lys Met Ile Gln            
1835                 1840                 1845                            

gat  tct ggc aag gtc aac  cct aag gat ctg gat  tct aag tat gca        5647
Asp  Ser Gly Lys Val Asn  Pro Lys Asp Leu Asp  Ser Lys Tyr Ala            
1850                 1855                 1860                            

tac  atc cag gtg act cac  gtc atc ccc ttc ttt  gac gaa aaa gag        5692
Tyr  Ile Gln Val Thr His  Val Ile Pro Phe Phe  Asp Glu Lys Glu            
1865                 1870                 1875                            

ttg  caa gaa agg aaa aca  gag ttt gag aga tcc  cac aac atc cgc        5737
Leu  Gln Glu Arg Lys Thr  Glu Phe Glu Arg Ser  His Asn Ile Arg            
1880                 1885                 1890                            

cgc  ttc atg ttt gag atg  cca ttt acg cag acc  ggg aag agg cag        5782
Arg  Phe Met Phe Glu Met  Pro Phe Thr Gln Thr  Gly Lys Arg Gln            
1895                 1900                 1905                            

ggc  ggg gtg gaa gag cag  tgc aaa cgg cgc acc  atc ctg aca gcc        5827
Gly  Gly Val Glu Glu Gln  Cys Lys Arg Arg Thr  Ile Leu Thr Ala            
1910                 1915                 1920                            

ata  cac tgc ttc cct tat  gtg aag aag cgc atc  cct gtc atg tac        5872
Ile  His Cys Phe Pro Tyr  Val Lys Lys Arg Ile  Pro Val Met Tyr            
1925                 1930                 1935                            

cag  cac cac act gac ctg  aac ccc atc gag gtg  gcc att gac gag        5917
Gln  His His Thr Asp Leu  Asn Pro Ile Glu Val  Ala Ile Asp Glu            
1940                 1945                 1950                            

atg  agt aag aag gtg gcg  gag ctc cgg cag ctg  tgc tcc tcg gcc        5962
Met  Ser Lys Lys Val Ala  Glu Leu Arg Gln Leu  Cys Ser Ser Ala            
1955                 1960                 1965                            

gag  gtg gac atg atc aaa  ctg cag ctc aaa ctc  cag ggc agc gtg        6007
Glu  Val Asp Met Ile Lys  Leu Gln Leu Lys Leu  Gln Gly Ser Val            
1970                 1975                 1980                            

agt  gtt cag gtc aat gct  ggc cca cta gca tat  gcg cga gct ttc        6052
Ser  Val Gln Val Asn Ala  Gly Pro Leu Ala Tyr  Ala Arg Ala Phe            
1985                 1990                 1995                            

tta  gat gat aca aac aca  aag cga tat cct gac  aat aaa gtg aag        6097
Leu  Asp Asp Thr Asn Thr  Lys Arg Tyr Pro Asp  Asn Lys Val Lys            
2000                 2005                 2010                            

ctg  ctt aag gaa gtt ttc  agg caa ttt gtg gaa  gct tgc ggt caa        6142
Leu  Leu Lys Glu Val Phe  Arg Gln Phe Val Glu  Ala Cys Gly Gln            
2015                 2020                 2025                            

gcc  tta gcg gta aac gaa  cgt ctg att aaa gaa  gac cag ctc gag        6187
Ala  Leu Ala Val Asn Glu  Arg Leu Ile Lys Glu  Asp Gln Leu Glu            
2030                 2035                 2040                            

tat  cag gaa gaa atg aaa  gcc aac tac agg gaa  atg gcg aag gag        6232
Tyr  Gln Glu Glu Met Lys  Ala Asn Tyr Arg Glu  Met Ala Lys Glu            
2045                 2050                 2055                            

ctt  tct gaa atc atg cat  gag cag ctg gga tga tctgccccct              6275
Leu  Ser Glu Ile Met His  Glu Gln Leu Gly                                 
2060                 2065                                                 

ggaggagaag acgagcgtct taccgaattc ccttcacatc ttcaacgcca tcagtgggac     6335

tccaacaagc acaatggttc acgggatgac cagctcgtct tcggtcgtgt gattacatct     6395

catggcccgt gtgtggggac ttgctttgtc atttgcaaac tcaggatgct ttccaaagcc     6455

aatcactggg gagaccgagc acagggagga ccaaggggaa ggggagagaa aggaaataaa     6515

gaacaacgtt atttcttaac agactttcta taggagttgt aagaaggtgc acatattttt     6575

ttaaatctca ctggcaatat tcaaagtttt cattgtgtct taacaaaggt gtggtagaca     6635

ctcttgagct ggacttagat tttattcttc cttgcagagt agtgttagaa tagatggcct     6695

acagaaaaaa aaggttctgg gatctacatg gcagggaggg ctgcactgac attgatgcct     6755

gggggacctt ttgcctcgag gctgagctgg aaaatcttga aaatattttt tttttcctgt     6815

ggcacattca ggttgaatac aagaactatt tttgtgacta gtttttgatg acctaaggga     6875

actgaccatt gtaatttttg taccagtgaa ccaggagatt tagtgctttt atattcattt     6935

ccttgcattt aagaaaatat gaaagcttaa ggaattatgt gagcttaaaa ctagtcaagc     6995

agtttagaac caaaggccta tattaataac cgcaactatg ctgaaaagta caaagtagta     7055

cagtatattg ttatgtacat atcattgtta atacagtcct ggcattctgt acatatatgt     7115

attacatttc tacattttta atactcacat gggcttatgc attaagttta attgtgataa     7175

atttgtgctg ttccagtata tgcaatacac tttaatgttt tattcttgta cataaaaatg     7235

tgcaatatgg agatgtatac agtctttact atattaggtt tataaacagt tttaagaatt     7295

tcatcctttt gccaaaatgg tggagtatgt aattggtaaa tcataaatcc tgtggtgaat     7355

ggtggtgtac tttaaagctg tcaccatgtt atattttctt ttaagacttt aatttagtaa     7415

ttttatattt gggaaaataa aggtttttaa ttttatttaa ctggaatcac tgccctgctg     7475

taattaaaca ttctgtacca catctgtatt aaaaagacat tgctgaccat taaaaaaaaa     7535

aaaaaaaaa                                                             7544


<210>  672
<211>  2069
<212>  PRT
<213>  Homo sapiens

<400>  672

Met Ser Gln Pro Pro Leu Leu Pro Ala Ser Ala Glu Thr Arg Lys Phe 
1               5                   10                  15      


Thr Arg Ala Leu Ser Lys Pro Gly Thr Ala Ala Glu Leu Arg Gln Ser 
            20                  25                  30          


Val Ser Glu Val Val Arg Gly Ser Val Leu Leu Ala Lys Pro Lys Leu 
        35                  40                  45              


Ile Glu Pro Leu Asp Tyr Glu Asn Val Ile Val Gln Lys Lys Thr Gln 
    50                  55                  60                  


Ile Leu Asn Asp Cys Leu Arg Glu Met Leu Leu Phe Pro Tyr Asp Asp 
65                  70                  75                  80  


Phe Gln Thr Ala Ile Leu Arg Arg Gln Gly Arg Tyr Ile Cys Ser Thr 
                85                  90                  95      


Val Pro Ala Lys Ala Glu Glu Glu Ala Gln Ser Leu Phe Val Thr Glu 
            100                 105                 110         


Cys Ile Lys Thr Tyr Asn Ser Asp Trp His Leu Val Asn Tyr Lys Tyr 
        115                 120                 125             


Glu Asp Tyr Ser Gly Glu Phe Arg Gln Leu Pro Asn Lys Val Val Lys 
    130                 135                 140                 


Leu Asp Lys Leu Pro Val His Val Tyr Glu Val Asp Glu Glu Val Asp 
145                 150                 155                 160 


Lys Asp Glu Asp Ala Ala Ser Leu Gly Ser Gln Lys Gly Gly Ile Thr 
                165                 170                 175     


Lys His Gly Trp Leu Tyr Lys Gly Asn Met Asn Ser Ala Ile Ser Val 
            180                 185                 190         


Thr Met Arg Ser Phe Lys Arg Arg Phe Phe His Leu Ile Gln Leu Gly 
        195                 200                 205             


Asp Gly Ser Tyr Asn Leu Asn Phe Tyr Lys Asp Glu Lys Ile Ser Lys 
    210                 215                 220                 


Glu Pro Lys Gly Ser Ile Phe Leu Asp Ser Cys Met Gly Val Val Gln 
225                 230                 235                 240 


Asn Asn Lys Val Arg Arg Phe Ala Phe Glu Leu Lys Met Gln Asp Lys 
                245                 250                 255     


Ser Ser Tyr Leu Leu Ala Ala Asp Ser Glu Val Glu Met Glu Glu Trp 
            260                 265                 270         


Ile Thr Ile Leu Asn Lys Ile Leu Gln Leu Asn Phe Glu Ala Ala Met 
        275                 280                 285             


Gln Glu Lys Arg Asn Gly Asp Ser His Glu Asp Asp Glu Gln Ser Lys 
    290                 295                 300                 


Leu Glu Gly Ser Gly Ser Gly Leu Asp Ser Tyr Leu Pro Glu Leu Ala 
305                 310                 315                 320 


Lys Ser Ala Arg Glu Ala Glu Ile Lys Leu Lys Ser Glu Ser Arg Val 
                325                 330                 335     


Lys Leu Phe Tyr Leu Asp Pro Asp Ala Gln Lys Leu Asp Phe Ser Ser 
            340                 345                 350         


Ala Glu Pro Glu Val Lys Ser Phe Glu Glu Lys Phe Gly Lys Arg Ile 
        355                 360                 365             


Leu Val Lys Cys Asn Asp Leu Ser Phe Asn Leu Gln Cys Cys Val Ala 
    370                 375                 380                 


Glu Asn Glu Glu Gly Pro Thr Thr Asn Val Glu Pro Phe Phe Val Thr 
385                 390                 395                 400 


Leu Ser Leu Phe Asp Ile Lys Tyr Asn Arg Lys Ile Ser Ala Asp Phe 
                405                 410                 415     


His Val Asp Leu Asn His Phe Ser Val Arg Gln Met Leu Ala Thr Thr 
            420                 425                 430         


Ser Pro Ala Leu Met Asn Gly Ser Gly Gln Ser Pro Ser Val Leu Lys 
        435                 440                 445             


Gly Ile Leu His Glu Ala Ala Met Gln Tyr Pro Lys Gln Gly Ile Phe 
    450                 455                 460                 


Ser Val Thr Cys Pro His Pro Asp Ile Phe Leu Val Ala Arg Ile Glu 
465                 470                 475                 480 


Lys Val Leu Gln Gly Ser Ile Thr His Cys Ala Glu Pro Tyr Met Lys 
                485                 490                 495     


Ser Ser Asp Ser Ser Lys Val Ala Gln Lys Val Leu Lys Asn Ala Lys 
            500                 505                 510         


Gln Ala Cys Gln Arg Leu Gly Gln Tyr Arg Met Pro Phe Ala Trp Ala 
        515                 520                 525             


Ala Arg Thr Leu Phe Lys Asp Ala Ser Gly Asn Leu Asp Lys Asn Ala 
    530                 535                 540                 


Arg Phe Ser Ala Ile Tyr Arg Gln Asp Ser Asn Lys Leu Ser Asn Asp 
545                 550                 555                 560 


Asp Met Leu Lys Leu Leu Ala Asp Phe Arg Lys Pro Glu Lys Met Ala 
                565                 570                 575     


Lys Leu Pro Val Ile Leu Gly Asn Leu Asp Ile Thr Ile Asp Asn Val 
            580                 585                 590         


Ser Ser Asp Phe Pro Asn Tyr Val Asn Ser Ser Tyr Ile Pro Thr Lys 
        595                 600                 605             


Gln Phe Glu Thr Cys Ser Lys Thr Pro Ile Thr Phe Glu Val Glu Glu 
    610                 615                 620                 


Phe Val Pro Cys Ile Pro Lys His Thr Gln Pro Tyr Thr Ile Tyr Thr 
625                 630                 635                 640 


Asn His Leu Tyr Val Tyr Pro Lys Tyr Leu Lys Tyr Asp Ser Gln Lys 
                645                 650                 655     


Ser Phe Ala Lys Ala Arg Asn Ile Ala Ile Cys Ile Glu Phe Lys Asp 
            660                 665                 670         


Ser Asp Glu Glu Asp Ser Gln Pro Leu Lys Cys Ile Tyr Gly Arg Pro 
        675                 680                 685             


Gly Gly Pro Val Phe Thr Arg Ser Ala Phe Ala Ala Val Leu His His 
    690                 695                 700                 


His Gln Asn Pro Glu Phe Tyr Asp Glu Ile Lys Ile Glu Leu Pro Thr 
705                 710                 715                 720 


Gln Leu His Glu Lys His His Leu Leu Leu Thr Phe Phe His Val Ser 
                725                 730                 735     


Cys Asp Asn Ser Ser Lys Gly Ser Thr Lys Lys Arg Asp Val Val Glu 
            740                 745                 750         


Thr Gln Val Gly Tyr Ser Trp Leu Pro Leu Leu Lys Asp Gly Arg Val 
        755                 760                 765             


Val Thr Ser Glu Gln His Ile Pro Val Ser Ala Asn Leu Pro Ser Gly 
    770                 775                 780                 


Tyr Leu Gly Tyr Gln Glu Leu Gly Met Gly Arg His Tyr Gly Pro Glu 
785                 790                 795                 800 


Ile Lys Trp Val Asp Gly Gly Lys Pro Leu Leu Lys Ile Ser Thr His 
                805                 810                 815     


Leu Val Ser Thr Val Tyr Thr Gln Asp Gln His Leu His Asn Phe Phe 
            820                 825                 830         


Gln Tyr Cys Gln Lys Thr Glu Ser Gly Ala Gln Ala Leu Gly Asn Glu 
        835                 840                 845             


Leu Val Lys Tyr Leu Lys Ser Leu His Ala Met Glu Gly His Val Met 
    850                 855                 860                 


Ile Ala Phe Leu Pro Thr Ile Leu Asn Gln Leu Phe Arg Val Leu Thr 
865                 870                 875                 880 


Arg Ala Thr Gln Glu Glu Val Ala Val Asn Val Thr Arg Val Ile Ile 
                885                 890                 895     


His Val Val Ala Gln Cys His Glu Glu Gly Leu Glu Ser His Leu Arg 
            900                 905                 910         


Ser Tyr Val Lys Tyr Ala Tyr Lys Ala Glu Pro Tyr Val Ala Ser Glu 
        915                 920                 925             


Tyr Lys Thr Val His Glu Glu Leu Thr Lys Ser Met Thr Thr Ile Leu 
    930                 935                 940                 


Lys Pro Ser Ala Asp Phe Leu Thr Ser Asn Lys Leu Leu Lys Tyr Ser 
945                 950                 955                 960 


Trp Phe Phe Phe Asp Val Leu Ile Lys Ser Met Ala Gln His Leu Ile 
                965                 970                 975     


Glu Asn Ser Lys Val Lys Leu Leu Arg Asn Gln Arg Phe Pro Ala Ser 
            980                 985                 990         


Tyr His His Ala Val Glu Thr Val  Val Asn Met Leu Met  Pro His Ile 
        995                 1000                 1005             


Thr Gln  Lys Phe Arg Asp Asn  Pro Glu Ala Ser Lys  Asn Ala Asn 
    1010                 1015                 1020             


His Ser  Leu Ala Val Phe Ile  Lys Arg Cys Phe Thr  Phe Met Asp 
    1025                 1030                 1035             


Arg Gly  Phe Val Phe Lys Gln  Ile Asn Asn Tyr Ile  Ser Cys Phe 
    1040                 1045                 1050             


Ala Pro  Gly Asp Pro Lys Thr  Leu Phe Glu Tyr Lys  Phe Glu Phe 
    1055                 1060                 1065             


Leu Arg  Val Val Cys Asn His  Glu His Tyr Ile Pro  Leu Asn Leu 
    1070                 1075                 1080             


Pro Met  Pro Phe Gly Lys Gly  Arg Ile Gln Arg Tyr  Gln Asp Leu 
    1085                 1090                 1095             


Gln Leu  Asp Tyr Ser Leu Thr  Asp Glu Phe Cys Arg  Asn His Phe 
    1100                 1105                 1110             


Leu Val  Gly Leu Leu Leu Arg  Glu Val Gly Thr Ala  Leu Gln Glu 
    1115                 1120                 1125             


Phe Arg  Glu Val Arg Leu Ile  Ala Ile Ser Val Leu  Lys Asn Leu 
    1130                 1135                 1140             


Leu Ile  Lys His Ser Phe Asp  Asp Arg Tyr Ala Ser  Arg Ser His 
    1145                 1150                 1155             


Gln Ala  Arg Ile Ala Thr Leu  Tyr Leu Pro Leu Phe  Gly Leu Leu 
    1160                 1165                 1170             


Ile Glu  Asn Val Gln Arg Ile  Asn Val Arg Asp Val  Ser Pro Phe 
    1175                 1180                 1185             


Pro Val  Asn Ala Gly Met Thr  Val Lys Asp Glu Ser  Leu Ala Leu 
    1190                 1195                 1200             


Pro Ala  Val Asn Pro Leu Val  Thr Pro Gln Lys Gly  Ser Thr Leu 
    1205                 1210                 1215             


Asp Asn  Ser Leu His Lys Asp  Leu Leu Gly Ala Ile  Ser Gly Ile 
    1220                 1225                 1230             


Ala Ser  Pro Tyr Thr Thr Ser  Thr Pro Asn Ile Asn  Ser Val Arg 
    1235                 1240                 1245             


Asn Ala  Asp Ser Arg Gly Ser  Leu Ile Ser Thr Asp  Ser Gly Asn 
    1250                 1255                 1260             


Ser Leu  Pro Glu Arg Asn Ser  Glu Lys Ser Asn Ser  Leu Asp Lys 
    1265                 1270                 1275             


His Gln  Gln Ser Ser Thr Leu  Gly Asn Ser Val Val  Arg Cys Asp 
    1280                 1285                 1290             


Lys Leu  Asp Gln Ser Glu Ile  Lys Ser Leu Leu Met  Cys Phe Leu 
    1295                 1300                 1305             


Tyr Ile  Leu Lys Ser Met Ser  Asp Asp Ala Leu Phe  Thr Tyr Trp 
    1310                 1315                 1320             


Asn Lys  Ala Ser Thr Ser Glu  Leu Met Asp Phe Phe  Thr Ile Ser 
    1325                 1330                 1335             


Glu Val  Cys Leu His Gln Phe  Gln Tyr Met Gly Lys  Arg Tyr Ile 
    1340                 1345                 1350             


Ala Arg  Thr Gly Met Met His  Ala Arg Leu Gln Gln  Leu Gly Ser 
    1355                 1360                 1365             


Leu Asp  Asn Ser Leu Thr Phe  Asn His Ser Tyr Gly  His Ser Asp 
    1370                 1375                 1380             


Ala Asp  Val Leu His Gln Ser  Leu Leu Glu Ala Asn  Ile Ala Thr 
    1385                 1390                 1395             


Glu Val  Cys Leu Thr Ala Leu  Asp Thr Leu Ser Leu  Phe Thr Leu 
    1400                 1405                 1410             


Ala Phe  Lys Asn Gln Leu Leu  Ala Asp His Gly His  Asn Pro Leu 
    1415                 1420                 1425             


Met Lys  Lys Val Phe Asp Val  Tyr Leu Cys Phe Leu  Gln Lys His 
    1430                 1435                 1440             


Gln Ser  Glu Thr Ala Leu Lys  Asn Val Phe Thr Ala  Leu Arg Ser 
    1445                 1450                 1455             


Leu Ile  Tyr Lys Phe Pro Ser  Thr Phe Tyr Glu Gly  Arg Ala Asp 
    1460                 1465                 1470             


Met Cys  Ala Ala Leu Cys Tyr  Glu Ile Leu Lys Cys  Cys Asn Ser 
    1475                 1480                 1485             


Lys Leu  Ser Ser Ile Arg Thr  Glu Ala Ser Gln Leu  Leu Tyr Phe 
    1490                 1495                 1500             


Leu Met  Arg Asn Asn Phe Asp  Tyr Thr Gly Lys Lys  Ser Phe Val 
    1505                 1510                 1515             


Arg Thr  His Leu Gln Val Ile  Ile Ser Val Ser Gln  Leu Ile Ala 
    1520                 1525                 1530             


Asp Val  Val Gly Ile Gly Gly  Thr Arg Phe Gln Gln  Ser Leu Ser 
    1535                 1540                 1545             


Ile Ile  Asn Asn Cys Ala Asn  Ser Asp Arg Leu Ile  Lys His Thr 
    1550                 1555                 1560             


Ser Phe  Ser Ser Asp Val Lys  Asp Leu Thr Lys Arg  Ile Arg Thr 
    1565                 1570                 1575             


Val Leu  Met Ala Thr Ala Gln  Met Lys Glu His Glu  Asn Asp Pro 
    1580                 1585                 1590             


Glu Met  Leu Val Asp Leu Gln  Tyr Ser Leu Ala Lys  Ser Tyr Ala 
    1595                 1600                 1605             


Ser Thr  Pro Glu Leu Arg Lys  Thr Trp Leu Asp Ser  Met Ala Arg 
    1610                 1615                 1620             


Ile His  Val Lys Asn Gly Asp  Leu Ser Glu Ala Ala  Met Cys Tyr 
    1625                 1630                 1635             


Val His  Val Thr Ala Leu Val  Ala Glu Tyr Leu Thr  Arg Lys Glu 
    1640                 1645                 1650             


Ala Val  Gln Trp Glu Pro Pro  Leu Leu Pro His Ser  His Ser Ala 
    1655                 1660                 1665             


Cys Leu  Arg Arg Ser Arg Gly  Gly Val Phe Arg Gln  Gly Cys Thr 
    1670                 1675                 1680             


Ala Phe  Arg Val Ile Thr Pro  Asn Ile Asp Glu Glu  Ala Ser Met 
    1685                 1690                 1695             


Met Glu  Asp Val Gly Met Gln  Asp Val His Phe Asn  Glu Asp Val 
    1700                 1705                 1710             


Leu Met  Glu Leu Leu Glu Gln  Cys Ala Asp Gly Leu  Trp Lys Ala 
    1715                 1720                 1725             


Glu Arg  Tyr Glu Leu Ile Ala  Asp Ile Tyr Lys Leu  Ile Ile Pro 
    1730                 1735                 1740             


Ile Tyr  Glu Lys Arg Arg Asp  Phe Glu Arg Leu Ala  His Leu Tyr 
    1745                 1750                 1755             


Asp Thr  Leu His Arg Ala Tyr  Ser Lys Val Thr Glu  Val Met His 
    1760                 1765                 1770             


Ser Gly  Arg Arg Leu Leu Gly  Thr Tyr Phe Arg Val  Ala Phe Phe 
    1775                 1780                 1785             


Gly Gln  Ala Ala Gln Tyr Gln  Phe Thr Asp Ser Glu  Thr Asp Val 
    1790                 1795                 1800             


Glu Gly  Phe Phe Glu Asp Glu  Asp Gly Lys Glu Tyr  Ile Tyr Lys 
    1805                 1810                 1815             


Glu Pro  Lys Leu Thr Pro Leu  Ser Glu Ile Ser Gln  Arg Leu Leu 
    1820                 1825                 1830             


Lys Leu  Tyr Ser Asp Lys Phe  Gly Ser Glu Asn Val  Lys Met Ile 
    1835                 1840                 1845             


Gln Asp  Ser Gly Lys Val Asn  Pro Lys Asp Leu Asp  Ser Lys Tyr 
    1850                 1855                 1860             


Ala Tyr  Ile Gln Val Thr His  Val Ile Pro Phe Phe  Asp Glu Lys 
    1865                 1870                 1875             


Glu Leu  Gln Glu Arg Lys Thr  Glu Phe Glu Arg Ser  His Asn Ile 
    1880                 1885                 1890             


Arg Arg  Phe Met Phe Glu Met  Pro Phe Thr Gln Thr  Gly Lys Arg 
    1895                 1900                 1905             


Gln Gly  Gly Val Glu Glu Gln  Cys Lys Arg Arg Thr  Ile Leu Thr 
    1910                 1915                 1920             


Ala Ile  His Cys Phe Pro Tyr  Val Lys Lys Arg Ile  Pro Val Met 
    1925                 1930                 1935             


Tyr Gln  His His Thr Asp Leu  Asn Pro Ile Glu Val  Ala Ile Asp 
    1940                 1945                 1950             


Glu Met  Ser Lys Lys Val Ala  Glu Leu Arg Gln Leu  Cys Ser Ser 
    1955                 1960                 1965             


Ala Glu  Val Asp Met Ile Lys  Leu Gln Leu Lys Leu  Gln Gly Ser 
    1970                 1975                 1980             


Val Ser  Val Gln Val Asn Ala  Gly Pro Leu Ala Tyr  Ala Arg Ala 
    1985                 1990                 1995             


Phe Leu  Asp Asp Thr Asn Thr  Lys Arg Tyr Pro Asp  Asn Lys Val 
    2000                 2005                 2010             


Lys Leu  Leu Lys Glu Val Phe  Arg Gln Phe Val Glu  Ala Cys Gly 
    2015                 2020                 2025             


Gln Ala  Leu Ala Val Asn Glu  Arg Leu Ile Lys Glu  Asp Gln Leu 
    2030                 2035                 2040             


Glu Tyr  Gln Glu Glu Met Lys  Ala Asn Tyr Arg Glu  Met Ala Lys 
    2045                 2050                 2055             


Glu Leu  Ser Glu Ile Met His  Glu Gln Leu Gly 
    2060                 2065                 


<210>  673
<211>  655
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (104)..(472)

<400>  673
acttggtggg agacgctcaa gagagcaaga tgttctcgtg ttgcttctcc actttgagag       60

gttgctgctt caggaacgga gggagtgaga gccttttctg acg atg ccg aag aag        115
                                                Met Pro Lys Lys           
                                                1                         

gct cat ccc tca ccc cag acg cct gtc gcc cgt tgt aat aag gcg cat        163
Ala His Pro Ser Pro Gln Thr Pro Val Ala Arg Cys Asn Lys Ala His           
5                   10                  15                  20            

cca gct cct ggt cca tgt gca gaa gta aga gca ctg cca gca cca gcg        211
Pro Ala Pro Gly Pro Cys Ala Glu Val Arg Ala Leu Pro Ala Pro Ala           
                25                  30                  35                

gcg gag cca gag cca gca tgg gaa gag gcc cct cca gag aga gca ctg        259
Ala Glu Pro Glu Pro Ala Trp Glu Glu Ala Pro Pro Glu Arg Ala Leu           
            40                  45                  50                    

gag ctg gag gga gct cca gcc aag gac cag acc aat gag gag ctg cct        307
Glu Leu Glu Gly Ala Pro Ala Lys Asp Gln Thr Asn Glu Glu Leu Pro           
        55                  60                  65                        

gaa atc acg gag gtg ccg gag agc att aaa aga agg ctg gga gga aga        355
Glu Ile Thr Glu Val Pro Glu Ser Ile Lys Arg Arg Leu Gly Gly Arg           
    70                  75                  80                            

gtt cca gca gct acg cct gct ccc aga ggc aac ctc ctc ctc cag gca        403
Val Pro Ala Ala Thr Pro Ala Pro Arg Gly Asn Leu Leu Leu Gln Ala           
85                  90                  95                  100           

tgg atg cgg gtc cac agc tgg gca tcc agg ctg ttt gcc cct aat gtg        451
Trp Met Arg Val His Ser Trp Ala Ser Arg Leu Phe Ala Pro Asn Val           
                105                 110                 115               

ctg ccc ggg aca ggc cct taa caggcgggca gtgggtgagg ggaccaggag           502
Leu Pro Gly Thr Gly Pro                                                   
            120                                                           

gtggctccaa agggtaaagc aaacaaagct tttaacgaca gccgttgtgc cccaggctct      562

ccatgccacc acctgcccta ccatttatta atagtgttag aattacaagt tgatgaaacg      622

agattacaat aaagtttgat ttctgaaact tca                                   655


<210>  674
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  674

Met Pro Lys Lys Ala His Pro Ser Pro Gln Thr Pro Val Ala Arg Cys 
1               5                   10                  15      


Asn Lys Ala His Pro Ala Pro Gly Pro Cys Ala Glu Val Arg Ala Leu 
            20                  25                  30          


Pro Ala Pro Ala Ala Glu Pro Glu Pro Ala Trp Glu Glu Ala Pro Pro 
        35                  40                  45              


Glu Arg Ala Leu Glu Leu Glu Gly Ala Pro Ala Lys Asp Gln Thr Asn 
    50                  55                  60                  


Glu Glu Leu Pro Glu Ile Thr Glu Val Pro Glu Ser Ile Lys Arg Arg 
65                  70                  75                  80  


Leu Gly Gly Arg Val Pro Ala Ala Thr Pro Ala Pro Arg Gly Asn Leu 
                85                  90                  95      


Leu Leu Gln Ala Trp Met Arg Val His Ser Trp Ala Ser Arg Leu Phe 
            100                 105                 110         


Ala Pro Asn Val Leu Pro Gly Thr Gly Pro 
        115                 120         


<210>  675
<211>  1815
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (12)..(581)

<400>  675
cttagctgaa g atg act gac agt gtt att tat tcc atg tta gag ttg cct        50
             Met Thr Asp Ser Val Ile Tyr Ser Met Leu Glu Leu Pro          
             1               5                   10                       

acg gca acc caa gcc cag aat gac tat gga cca cag caa aaa tct tcc         98
Thr Ala Thr Gln Ala Gln Asn Asp Tyr Gly Pro Gln Gln Lys Ser Ser           
    15                  20                  25                            

tct tcc agg cct tct tgt tct tgc ctt gtg gca ata gct ttg ggg ctt        146
Ser Ser Arg Pro Ser Cys Ser Cys Leu Val Ala Ile Ala Leu Gly Leu           
30                  35                  40                  45            

ctg act gca gtt ctt ctg agt gtg ctg cta tac cag tgg atc ctg tgc        194
Leu Thr Ala Val Leu Leu Ser Val Leu Leu Tyr Gln Trp Ile Leu Cys           
                50                  55                  60                

cag ggc tcc aac tac tcc act tgt gcc agc tgt cct agc tgc cca gac        242
Gln Gly Ser Asn Tyr Ser Thr Cys Ala Ser Cys Pro Ser Cys Pro Asp           
            65                  70                  75                    

cgc tgg atg aaa tat ggt aac cat tgt tat tat ttc tca gtg gag gaa        290
Arg Trp Met Lys Tyr Gly Asn His Cys Tyr Tyr Phe Ser Val Glu Glu           
        80                  85                  90                        

aag gac tgg aat tct agt ctg gaa ttc tgc cta gcc aga gac tca cac        338
Lys Asp Trp Asn Ser Ser Leu Glu Phe Cys Leu Ala Arg Asp Ser His           
    95                  100                 105                           

ctc ctt gtg ata acg gac aat cag gaa atg agc ctg ctc caa gtt ttc        386
Leu Leu Val Ile Thr Asp Asn Gln Glu Met Ser Leu Leu Gln Val Phe           
110                 115                 120                 125           

ctc agt gag gcc ttt tgc tgg att ggt ctg agg aac aat tct ggc tgg        434
Leu Ser Glu Ala Phe Cys Trp Ile Gly Leu Arg Asn Asn Ser Gly Trp           
                130                 135                 140               

agg tgg gaa gat gga tca cct cta aac ttc tca agg att tct tct aat        482
Arg Trp Glu Asp Gly Ser Pro Leu Asn Phe Ser Arg Ile Ser Ser Asn           
            145                 150                 155                   

agc ttt gtg cag aca tgc ggt gcc atc aac aaa aat ggt ctt caa gcc        530
Ser Phe Val Gln Thr Cys Gly Ala Ile Asn Lys Asn Gly Leu Gln Ala           
        160                 165                 170                       

tca agc tgt gaa gtt cct tta cac tgg gtg tgt aag aag gtc aga ctt        578
Ser Ser Cys Glu Val Pro Leu His Trp Val Cys Lys Lys Val Arg Leu           
    175                 180                 185                           

tga tagatgacca ctctgtcctg accctcagat ctgtcatgta tccctaaaag             631

gagggagctg gccactggct gttgggaaag ccatgagtat atagttagca aatactgaac      691

tttctcagat atggcattag atgcaagaca acctcctagg gattgatgcc taactgatgg      751

attctctttg agactattta gatattatgt gagcaattta aagaccagat ctaagcaaat      811

tttgaaatag atgtttgttt tttgtatttc tcagtatgga aactaatgct gccactctca      871

tccccgtccc aaccatctct gtcaaaaata tacctttttc atatgatatt ctgagctaat      931

ctgataaaat ctatgccaat atatactatt gcttgtgtac tagagaagta cattattgct      991

gtactcctct gtacattact gatccctgat ggtatatttc tatcctaaca gtgtcccttt     1051

gcagatcaag ctttattctg aagaataaac ctagctggca tgctggtgtg tacctgtagt     1111

cctagctatt tgggaagctg aggtgggagg gtcgcttgag cccaggagtt tgaggctgca     1171

gtgagctatg attgtgccac tgtactccag cctgggagat agagcaagac tccatctcta     1231

aaaaaaaaaa aaaatgctaa tgtgagaata taaattgtgg gaaatgagtg agggcaaggt     1291

ggtacttcct ccttctgagc tcttcacacg taatgcaaaa acccggtctt aactgatttt     1351

gttttttttc tgagtatgca tatatgtggt tgaatgaacc aatgtgtgat tgtatctttt     1411

ccattatgtg actgtttgac ctgcatatta atttcaagat agcagtcaat tcgataaggc     1471

attttcatag aggaaagttt acagaaacag tttatgtggt tggatcacca aattatctta     1531

ggtactaagg cctcaaaaat aagaaaaact ttattatttc tcctcagtag agtttggaca     1591

tacataagga gagaaggtac agtgatgaag gagaccataa ttctgtagtg ttgatgatcc     1651

tggattataa tctttttctc tttatctttc atagtttttt taaaaacatg gactgtatct     1711

tatctaccac tatatcccaa atacctaaga tagtgcttac gttcagtgac tattaaataa     1771

ataaatggat gaattaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      1815


<210>  676
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  676

Met Thr Asp Ser Val Ile Tyr Ser Met Leu Glu Leu Pro Thr Ala Thr 
1               5                   10                  15      


Gln Ala Gln Asn Asp Tyr Gly Pro Gln Gln Lys Ser Ser Ser Ser Arg 
            20                  25                  30          


Pro Ser Cys Ser Cys Leu Val Ala Ile Ala Leu Gly Leu Leu Thr Ala 
        35                  40                  45              


Val Leu Leu Ser Val Leu Leu Tyr Gln Trp Ile Leu Cys Gln Gly Ser 
    50                  55                  60                  


Asn Tyr Ser Thr Cys Ala Ser Cys Pro Ser Cys Pro Asp Arg Trp Met 
65                  70                  75                  80  


Lys Tyr Gly Asn His Cys Tyr Tyr Phe Ser Val Glu Glu Lys Asp Trp 
                85                  90                  95      


Asn Ser Ser Leu Glu Phe Cys Leu Ala Arg Asp Ser His Leu Leu Val 
            100                 105                 110         


Ile Thr Asp Asn Gln Glu Met Ser Leu Leu Gln Val Phe Leu Ser Glu 
        115                 120                 125             


Ala Phe Cys Trp Ile Gly Leu Arg Asn Asn Ser Gly Trp Arg Trp Glu 
    130                 135                 140                 


Asp Gly Ser Pro Leu Asn Phe Ser Arg Ile Ser Ser Asn Ser Phe Val 
145                 150                 155                 160 


Gln Thr Cys Gly Ala Ile Asn Lys Asn Gly Leu Gln Ala Ser Ser Cys 
                165                 170                 175     


Glu Val Pro Leu His Trp Val Cys Lys Lys Val Arg Leu 
            180                 185                 


<210>  677
<211>  3041
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (135)..(1478)

<400>  677
gcgctctaac ggccaggccc agccgcttga ggctccccaa cggccaggcc gcgcccccgc       60

gtgcgtgcgc ggcccggcag agccgtgcgg gcgcccgcgt actcactagc tgaggtggca      120

gtggttccac caac atg gag ctc tcg cag atg tcg gag ctc atg ggg ctg        170
                Met Glu Leu Ser Gln Met Ser Glu Leu Met Gly Leu           
                1               5                   10                    

tcg gtg ttg ctt ggg ctg ctg gcc ctg atg gcg acg gcg gcg gta gcg        218
Ser Val Leu Leu Gly Leu Leu Ala Leu Met Ala Thr Ala Ala Val Ala           
        15                  20                  25                        

cgg ggg tgg ctg cgc gcg ggg gag gag agg agc ggc cgg ccc gcc tgc        266
Arg Gly Trp Leu Arg Ala Gly Glu Glu Arg Ser Gly Arg Pro Ala Cys           
    30                  35                  40                            

caa aaa gca aat gga ttt cca cct gac aaa tct tcg gga tcc aag aag        314
Gln Lys Ala Asn Gly Phe Pro Pro Asp Lys Ser Ser Gly Ser Lys Lys           
45                  50                  55                  60            

cag aaa caa tat cag cgg att cgg aag gag aag cct caa caa cac aac        362
Gln Lys Gln Tyr Gln Arg Ile Arg Lys Glu Lys Pro Gln Gln His Asn           
                65                  70                  75                

ttc acc cac cgc ctc ctg gct gca gct ctg aag agc cac agc ggg aac        410
Phe Thr His Arg Leu Leu Ala Ala Ala Leu Lys Ser His Ser Gly Asn           
            80                  85                  90                    

ata tct tgc atg gac ttt agc agc aat ggc aaa tac ctg gct acc tgt        458
Ile Ser Cys Met Asp Phe Ser Ser Asn Gly Lys Tyr Leu Ala Thr Cys           
        95                  100                 105                       

gca gat gat cgc acc atc cgc atc tgg agc acc aag gac ttc ctg cag        506
Ala Asp Asp Arg Thr Ile Arg Ile Trp Ser Thr Lys Asp Phe Leu Gln           
    110                 115                 120                           

cga gag cac cgc agc atg aga gcc aac gtg gag ctg gac cac gcc acc        554
Arg Glu His Arg Ser Met Arg Ala Asn Val Glu Leu Asp His Ala Thr           
125                 130                 135                 140           

ctg gtg cgc ttc agc cct gac tgc aga gcc ttc atc gtc tgg ctg gcc        602
Leu Val Arg Phe Ser Pro Asp Cys Arg Ala Phe Ile Val Trp Leu Ala           
                145                 150                 155               

aac ggg gac acc ctc cgt gtc ttc aag atg acc aag cgg gag gat ggg        650
Asn Gly Asp Thr Leu Arg Val Phe Lys Met Thr Lys Arg Glu Asp Gly           
            160                 165                 170                   

ggc tac acc ttc aca gcc acc cca gag gac ttc cct aaa aag cac aag        698
Gly Tyr Thr Phe Thr Ala Thr Pro Glu Asp Phe Pro Lys Lys His Lys           
        175                 180                 185                       

gcg cct gtc atc gac att ggc att gct aac aca ggg aag ttt atc atg        746
Ala Pro Val Ile Asp Ile Gly Ile Ala Asn Thr Gly Lys Phe Ile Met           
    190                 195                 200                           

act gcc tcc agt gac acc act gtc ctc atc tgg agc ctg aag ggt caa        794
Thr Ala Ser Ser Asp Thr Thr Val Leu Ile Trp Ser Leu Lys Gly Gln           
205                 210                 215                 220           

gtg ctg tct acc atc aac acc aac cag atg aac aac aca cac gct gct        842
Val Leu Ser Thr Ile Asn Thr Asn Gln Met Asn Asn Thr His Ala Ala           
                225                 230                 235               

gta tct ccc tgt ggc aga ttt gta gcc tcg tgt ggc ttc acc cca gat        890
Val Ser Pro Cys Gly Arg Phe Val Ala Ser Cys Gly Phe Thr Pro Asp           
            240                 245                 250                   

gtg aag gtt tgg gaa gtc tgc ttt gga aag aag ggg gag ttc cag gag        938
Val Lys Val Trp Glu Val Cys Phe Gly Lys Lys Gly Glu Phe Gln Glu           
        255                 260                 265                       

gtg gtg cga gcc ttc gaa cta aag ggc cac tcc gcg gct gtg cac tcg        986
Val Val Arg Ala Phe Glu Leu Lys Gly His Ser Ala Ala Val His Ser           
    270                 275                 280                           

ttt gct ttc tcc aac gac tca cgg agg atg gct tct gtc tcc aag gat       1034
Phe Ala Phe Ser Asn Asp Ser Arg Arg Met Ala Ser Val Ser Lys Asp           
285                 290                 295                 300           

ggt aca tgg aaa ctg tgg gac aca gat gtg gaa tac aag aag aag cag       1082
Gly Thr Trp Lys Leu Trp Asp Thr Asp Val Glu Tyr Lys Lys Lys Gln           
                305                 310                 315               

gac ccc tac ttg ctg aag aca ggc cgc ttt gaa gag gcg gcg ggt gcc       1130
Asp Pro Tyr Leu Leu Lys Thr Gly Arg Phe Glu Glu Ala Ala Gly Ala           
            320                 325                 330                   

gcg ccg tgc cgc ctg gcc ctc tcc ccc aac gcc cag gtc ttg gcc ttg       1178
Ala Pro Cys Arg Leu Ala Leu Ser Pro Asn Ala Gln Val Leu Ala Leu           
        335                 340                 345                       

gcc agt ggc agt agt att cat ctc tac aat acc cgg cgg ggc gag aag       1226
Ala Ser Gly Ser Ser Ile His Leu Tyr Asn Thr Arg Arg Gly Glu Lys           
    350                 355                 360                           

gag gag tgc ttt gag cgg gtc cat ggc gag tgt atc gcc aac ttg tcc       1274
Glu Glu Cys Phe Glu Arg Val His Gly Glu Cys Ile Ala Asn Leu Ser           
365                 370                 375                 380           

ttt gac atc act ggc cgc ttt ctg gcc tcc tgt ggg gac cgg gcg gtg       1322
Phe Asp Ile Thr Gly Arg Phe Leu Ala Ser Cys Gly Asp Arg Ala Val           
                385                 390                 395               

cgg ctg ttt cac aac act cct ggc cac cga gcc atg gtg gag gag atg       1370
Arg Leu Phe His Asn Thr Pro Gly His Arg Ala Met Val Glu Glu Met           
            400                 405                 410                   

cag ggc cac ctg aag cgg gcc tcc aac gag agc acc cgc cag agg ctg       1418
Gln Gly His Leu Lys Arg Ala Ser Asn Glu Ser Thr Arg Gln Arg Leu           
        415                 420                 425                       

cag cag cag ctg acc cag gcc caa gag acc ctg aag agc ctg ggt gcc       1466
Gln Gln Gln Leu Thr Gln Ala Gln Glu Thr Leu Lys Ser Leu Gly Ala           
    430                 435                 440                           

ctg aag aag tga ctctgggagg gcccggcgca gaggattgag gaggagggat           1518
Leu Lys Lys                                                               
445                                                                       

ctggcctcct catggcactg ctgccatctt tcctcccagg tggaagcctt tcagaaggag     1578

tctcctggtt ttcttactgg tggccctgct tcttcccatt gaaactactc ttgtctactt     1638

aggtctctct cttcttgctg gctgtgactc ctccctgact agtggccaag gtgcttttct     1698

tcctcccagg cccagtgggt ggaatctgtc cccacctggc actgaggaga atggtagaga     1758

ggagaggaga gagagagaga atgtgatttt tggccttgtg gcagcacatc ctcacaccca     1818

aagaagtttg taaatgttcc agaacaacct agagaacacc tgagtactaa gcagcagttt     1878

tgcaaggatg ggagactggg atagcttccc atcacagaac tgtgttccat caaaaagaca     1938

ctaagggatt tccttctggg cctcagttct atttgtaaga tggagaataa tcctctctgt     1998

gaactccttg caaagatgat atgaggctaa gagaatatca agtccccagg tctggaagaa     2058

aagtagaaaa gagtagtact attgtccaat gtcatgaaag tggtaaaagt gggaaccagt     2118

gtgctttgaa accaaattag aaacacattc cttgggaagg caaagttttc tgggacttga     2178

tcatacattt tatatggttg ggacttctct cttcgggaga tgatatcttg tttaaggaga     2238

cctcttttca gttcatcaag ttcatcagat atttgagtgc ccactctgtg cccaaataaa     2298

tatgagctgg ggattaaata cgaataagac atggtttctg ccatcaaaga tggctggtgg     2358

gagagagaga tacaccctta ttaagtgctt tgtgttagtt tattcatagc tattgttata     2418

tatgtcaagg caagagagga ccagagcagg acagaggcaa tgggtattga agttgaaggg     2478

gtacatttga taagagagtc ggtattgaga agtttaaatt tgtgaatttg aaggctgcgt     2538

gggtgtggca ggtaagggaa atgaggtatc tgggaaggct tgagtgtagg caaatttatt     2598

catcccaagt caaactcttg atctctctca cgaaaactat gaccccccct ggttgcccct     2658

gacctctcaa tgttggaaca agccacaacc gtggagttat ccttgatgac tccccattca     2718

ttatcccttc tgtcccacca ccacagctgt catctgttca ccagaacgtt cttttggtta     2778

cactccatgt gacatcctga ggctgttgct tctctccagc ttttctgtta ccatcctggt     2838

cctggctact gtcacctagt gggccactat aatatggctt cctaatggat cttcctgctt     2898

cctctgttgc ctcattactt ttctatatag cagaatgatc ttttgaaaat gtgaaccaga     2958

tcacattatt ccctagttaa aaccccccaa ggcttcccat cacacttgga ataaaatcca     3018

aaagaatttt tctaaaccaa aaa                                             3041


<210>  678
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  678

Met Glu Leu Ser Gln Met Ser Glu Leu Met Gly Leu Ser Val Leu Leu 
1               5                   10                  15      


Gly Leu Leu Ala Leu Met Ala Thr Ala Ala Val Ala Arg Gly Trp Leu 
            20                  25                  30          


Arg Ala Gly Glu Glu Arg Ser Gly Arg Pro Ala Cys Gln Lys Ala Asn 
        35                  40                  45              


Gly Phe Pro Pro Asp Lys Ser Ser Gly Ser Lys Lys Gln Lys Gln Tyr 
    50                  55                  60                  


Gln Arg Ile Arg Lys Glu Lys Pro Gln Gln His Asn Phe Thr His Arg 
65                  70                  75                  80  


Leu Leu Ala Ala Ala Leu Lys Ser His Ser Gly Asn Ile Ser Cys Met 
                85                  90                  95      


Asp Phe Ser Ser Asn Gly Lys Tyr Leu Ala Thr Cys Ala Asp Asp Arg 
            100                 105                 110         


Thr Ile Arg Ile Trp Ser Thr Lys Asp Phe Leu Gln Arg Glu His Arg 
        115                 120                 125             


Ser Met Arg Ala Asn Val Glu Leu Asp His Ala Thr Leu Val Arg Phe 
    130                 135                 140                 


Ser Pro Asp Cys Arg Ala Phe Ile Val Trp Leu Ala Asn Gly Asp Thr 
145                 150                 155                 160 


Leu Arg Val Phe Lys Met Thr Lys Arg Glu Asp Gly Gly Tyr Thr Phe 
                165                 170                 175     


Thr Ala Thr Pro Glu Asp Phe Pro Lys Lys His Lys Ala Pro Val Ile 
            180                 185                 190         


Asp Ile Gly Ile Ala Asn Thr Gly Lys Phe Ile Met Thr Ala Ser Ser 
        195                 200                 205             


Asp Thr Thr Val Leu Ile Trp Ser Leu Lys Gly Gln Val Leu Ser Thr 
    210                 215                 220                 


Ile Asn Thr Asn Gln Met Asn Asn Thr His Ala Ala Val Ser Pro Cys 
225                 230                 235                 240 


Gly Arg Phe Val Ala Ser Cys Gly Phe Thr Pro Asp Val Lys Val Trp 
                245                 250                 255     


Glu Val Cys Phe Gly Lys Lys Gly Glu Phe Gln Glu Val Val Arg Ala 
            260                 265                 270         


Phe Glu Leu Lys Gly His Ser Ala Ala Val His Ser Phe Ala Phe Ser 
        275                 280                 285             


Asn Asp Ser Arg Arg Met Ala Ser Val Ser Lys Asp Gly Thr Trp Lys 
    290                 295                 300                 


Leu Trp Asp Thr Asp Val Glu Tyr Lys Lys Lys Gln Asp Pro Tyr Leu 
305                 310                 315                 320 


Leu Lys Thr Gly Arg Phe Glu Glu Ala Ala Gly Ala Ala Pro Cys Arg 
                325                 330                 335     


Leu Ala Leu Ser Pro Asn Ala Gln Val Leu Ala Leu Ala Ser Gly Ser 
            340                 345                 350         


Ser Ile His Leu Tyr Asn Thr Arg Arg Gly Glu Lys Glu Glu Cys Phe 
        355                 360                 365             


Glu Arg Val His Gly Glu Cys Ile Ala Asn Leu Ser Phe Asp Ile Thr 
    370                 375                 380                 


Gly Arg Phe Leu Ala Ser Cys Gly Asp Arg Ala Val Arg Leu Phe His 
385                 390                 395                 400 


Asn Thr Pro Gly His Arg Ala Met Val Glu Glu Met Gln Gly His Leu 
                405                 410                 415     


Lys Arg Ala Ser Asn Glu Ser Thr Arg Gln Arg Leu Gln Gln Gln Leu 
            420                 425                 430         


Thr Gln Ala Gln Glu Thr Leu Lys Ser Leu Gly Ala Leu Lys Lys 
        435                 440                 445         


<210>  679
<211>  1128
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (229)..(1062)

<400>  679
gcgtgggcag ggggcgggcc cgggagttgg aacagagggc acagacggcc cctcctcgga       60

ggggagggac cggagccggg gcctttttct ttaagactcg cagcactgga tcccagaact      120

tagtctgcgc ggcggcattg acactagctg ggctcctcgg ggcgcgcccc aggtggtccg      180

aagcccggtc cgccctccac gcaggtgccc cgcgctcccc gctcagcc atg tcg tcc       237
                                                     Met Ser Ser          
                                                     1                    

tgc agc cgc gtg gcg ctg gtg acc ggg gcc aac agg ggc atc ggc ttg        285
Cys Ser Arg Val Ala Leu Val Thr Gly Ala Asn Arg Gly Ile Gly Leu           
    5                   10                  15                            

gcc atc gcg cgc gaa ctg tgc cga cag ttc tct ggg gat gtg gtg ctc        333
Ala Ile Ala Arg Glu Leu Cys Arg Gln Phe Ser Gly Asp Val Val Leu           
20                  25                  30                  35            

acc gcg cgg gac gtg gcg cgg ggc cag gcg gcc gtg cag cag ctg cag        381
Thr Ala Arg Asp Val Ala Arg Gly Gln Ala Ala Val Gln Gln Leu Gln           
                40                  45                  50                

gcg gag ggc ctg agc ccg cgc ttc cac caa ctg gac atc gac gac ttg        429
Ala Glu Gly Leu Ser Pro Arg Phe His Gln Leu Asp Ile Asp Asp Leu           
            55                  60                  65                    

cag agc atc cgc gcc ctg cgc gac ttc ctg cgc aag gag tac ggg ggg        477
Gln Ser Ile Arg Ala Leu Arg Asp Phe Leu Arg Lys Glu Tyr Gly Gly           
        70                  75                  80                        

ctc aac gta ctg gtc aac aac gcg gcc gtc gcc ttc aag agt gat gat        525
Leu Asn Val Leu Val Asn Asn Ala Ala Val Ala Phe Lys Ser Asp Asp           
    85                  90                  95                            

cca atg ccc ttt gac att aaa gct gag atg aca ctg aag aca aat ttt        573
Pro Met Pro Phe Asp Ile Lys Ala Glu Met Thr Leu Lys Thr Asn Phe           
100                 105                 110                 115           

ttt gcc act aga aac atg tgc aac gag tta ctg ccg ata atg aaa cct        621
Phe Ala Thr Arg Asn Met Cys Asn Glu Leu Leu Pro Ile Met Lys Pro           
                120                 125                 130               

cat ggg aga gtg gtg aat atc agt agt ttg cag tgt tta agg gct ttt        669
His Gly Arg Val Val Asn Ile Ser Ser Leu Gln Cys Leu Arg Ala Phe           
            135                 140                 145                   

gaa aac tgc agt gaa gat ctg cag gaa agg ttc cac agt gag aca ctc        717
Glu Asn Cys Ser Glu Asp Leu Gln Glu Arg Phe His Ser Glu Thr Leu           
        150                 155                 160                       

aca gaa gga gac ctg gtg gat ctc atg aaa aag ttt gtg gag gac aca        765
Thr Glu Gly Asp Leu Val Asp Leu Met Lys Lys Phe Val Glu Asp Thr           
    165                 170                 175                           

aaa aat gag gtg cat gag agg gaa ggc tgg ccc aac tca cct tat ggg        813
Lys Asn Glu Val His Glu Arg Glu Gly Trp Pro Asn Ser Pro Tyr Gly           
180                 185                 190                 195           

gtg tcc aag ttg ggg gtc acg gtc tta tcg agg atc ctg gcc agg cgt        861
Val Ser Lys Leu Gly Val Thr Val Leu Ser Arg Ile Leu Ala Arg Arg           
                200                 205                 210               

ctg gat gag aag agg aaa gct gac agg att ctg gtg aat gcg tgc tgc        909
Leu Asp Glu Lys Arg Lys Ala Asp Arg Ile Leu Val Asn Ala Cys Cys           
            215                 220                 225                   

cca gga cca gtg aag aca gac atg gat ggg aaa gac agc atc agg act        957
Pro Gly Pro Val Lys Thr Asp Met Asp Gly Lys Asp Ser Ile Arg Thr           
        230                 235                 240                       

gtg gag gag ggg gct gag acc cct gtc tac ttg gcc ctc ttg cct cca       1005
Val Glu Glu Gly Ala Glu Thr Pro Val Tyr Leu Ala Leu Leu Pro Pro           
    245                 250                 255                           

gat gcc act gag cca caa ggc cag ttg gtc cat gac aaa gtt gtg caa       1053
Asp Ala Thr Glu Pro Gln Gly Gln Leu Val His Asp Lys Val Val Gln           
260                 265                 270                 275           

aac tgg taa acgtctgctt cggagcttgc tgcttaataa atgttggtgg               1102
Asn Trp                                                                   
                                                                          

aatgaatgaa aaaaaaaaaa aaaaaa                                          1128


<210>  680
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  680

Met Ser Ser Cys Ser Arg Val Ala Leu Val Thr Gly Ala Asn Arg Gly 
1               5                   10                  15      


Ile Gly Leu Ala Ile Ala Arg Glu Leu Cys Arg Gln Phe Ser Gly Asp 
            20                  25                  30          


Val Val Leu Thr Ala Arg Asp Val Ala Arg Gly Gln Ala Ala Val Gln 
        35                  40                  45              


Gln Leu Gln Ala Glu Gly Leu Ser Pro Arg Phe His Gln Leu Asp Ile 
    50                  55                  60                  


Asp Asp Leu Gln Ser Ile Arg Ala Leu Arg Asp Phe Leu Arg Lys Glu 
65                  70                  75                  80  


Tyr Gly Gly Leu Asn Val Leu Val Asn Asn Ala Ala Val Ala Phe Lys 
                85                  90                  95      


Ser Asp Asp Pro Met Pro Phe Asp Ile Lys Ala Glu Met Thr Leu Lys 
            100                 105                 110         


Thr Asn Phe Phe Ala Thr Arg Asn Met Cys Asn Glu Leu Leu Pro Ile 
        115                 120                 125             


Met Lys Pro His Gly Arg Val Val Asn Ile Ser Ser Leu Gln Cys Leu 
    130                 135                 140                 


Arg Ala Phe Glu Asn Cys Ser Glu Asp Leu Gln Glu Arg Phe His Ser 
145                 150                 155                 160 


Glu Thr Leu Thr Glu Gly Asp Leu Val Asp Leu Met Lys Lys Phe Val 
                165                 170                 175     


Glu Asp Thr Lys Asn Glu Val His Glu Arg Glu Gly Trp Pro Asn Ser 
            180                 185                 190         


Pro Tyr Gly Val Ser Lys Leu Gly Val Thr Val Leu Ser Arg Ile Leu 
        195                 200                 205             


Ala Arg Arg Leu Asp Glu Lys Arg Lys Ala Asp Arg Ile Leu Val Asn 
    210                 215                 220                 


Ala Cys Cys Pro Gly Pro Val Lys Thr Asp Met Asp Gly Lys Asp Ser 
225                 230                 235                 240 


Ile Arg Thr Val Glu Glu Gly Ala Glu Thr Pro Val Tyr Leu Ala Leu 
                245                 250                 255     


Leu Pro Pro Asp Ala Thr Glu Pro Gln Gly Gln Leu Val His Asp Lys 
            260                 265                 270         


Val Val Gln Asn Trp 
        275         


<210>  681
<211>  1408
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (66)..(1313)

<400>  681
ggggatctca tttctcccca gggggctcta ggctgtggat gtgagaaggg gagcaaggga       60

ggcag atg gcg aca agg aac agc ccc atg ccc ctg ggc acg gct cag ggt      110
      Met Ala Thr Arg Asn Ser Pro Met Pro Leu Gly Thr Ala Gln Gly         
      1               5                   10                  15          

gac cct gga gag gca gga aca cgg ccc ggc cct gac gcc agc ctc cgg        158
Asp Pro Gly Glu Ala Gly Thr Arg Pro Gly Pro Asp Ala Ser Leu Arg           
                20                  25                  30                

gac aca ggt gcg gcc act cag ctc aag atg aag ccc agg aag gtg cac        206
Asp Thr Gly Ala Ala Thr Gln Leu Lys Met Lys Pro Arg Lys Val His           
            35                  40                  45                    

aag atc aag gcg gtc atc atc gac ctg ggc tcc cag tac tgc aag tgc        254
Lys Ile Lys Ala Val Ile Ile Asp Leu Gly Ser Gln Tyr Cys Lys Cys           
        50                  55                  60                        

ggc tac gcg gga gag ccg agg ccc acc tac ttc atc tcc tcc acc gtg        302
Gly Tyr Ala Gly Glu Pro Arg Pro Thr Tyr Phe Ile Ser Ser Thr Val           
    65                  70                  75                            

ggc aaa cgc tgc ccc gag gcg gcc gac gct ggc gac acc cgc aag tgg        350
Gly Lys Arg Cys Pro Glu Ala Ala Asp Ala Gly Asp Thr Arg Lys Trp           
80                  85                  90                  95            

act tta gtg ggc cat gag ctg ctc aac acg gag gcg cct ctc aag ctg        398
Thr Leu Val Gly His Glu Leu Leu Asn Thr Glu Ala Pro Leu Lys Leu           
                100                 105                 110               

gtg aac ccg ctg aag cac ggc atc gtg gtg gac tgg gac tgc gtg cag        446
Val Asn Pro Leu Lys His Gly Ile Val Val Asp Trp Asp Cys Val Gln           
            115                 120                 125                   

gac atc tgg gag tac atc ttc cgc acc gcc atg aag atc ctc ccc gag        494
Asp Ile Trp Glu Tyr Ile Phe Arg Thr Ala Met Lys Ile Leu Pro Glu           
        130                 135                 140                       

gag cac gct gtg ctg gtc tcc gac cct ccg ctc agc ccc agc agc aac        542
Glu His Ala Val Leu Val Ser Asp Pro Pro Leu Ser Pro Ser Ser Asn           
    145                 150                 155                           

cgg gag aag tac gcg gag ctc atg ttt gag acc ttc ggc atc cca gcc        590
Arg Glu Lys Tyr Ala Glu Leu Met Phe Glu Thr Phe Gly Ile Pro Ala           
160                 165                 170                 175           

atg cac gtg acg tcc cag tcg ttg ctg tcc atc tac tcc tac ggc aag        638
Met His Val Thr Ser Gln Ser Leu Leu Ser Ile Tyr Ser Tyr Gly Lys           
                180                 185                 190               

acc tcg ggg ctg gtg gtg gag agc ggg cac ggc gtc tcg cac gtg gtg        686
Thr Ser Gly Leu Val Val Glu Ser Gly His Gly Val Ser His Val Val           
            195                 200                 205                   

ccc ata tcc gag ggc gac gtg ctg ccg ggc ctg acc agc cgc gcc gac        734
Pro Ile Ser Glu Gly Asp Val Leu Pro Gly Leu Thr Ser Arg Ala Asp           
        210                 215                 220                       

tac gct ggg ggt gac ctc acc aac tac ctg atg cag ctg ctc aat gag        782
Tyr Ala Gly Gly Asp Leu Thr Asn Tyr Leu Met Gln Leu Leu Asn Glu           
    225                 230                 235                           

gcg ggc cac gca ttc acg gac gac cac ctg cac atc ata gag cac atc        830
Ala Gly His Ala Phe Thr Asp Asp His Leu His Ile Ile Glu His Ile           
240                 245                 250                 255           

aag aag aag tgc tgc tat gcg gcc ttc ctg ccc gag gag gag ctg ggc        878
Lys Lys Lys Cys Cys Tyr Ala Ala Phe Leu Pro Glu Glu Glu Leu Gly           
                260                 265                 270               

ctg gtc ccg gag gag ctg cgc gtg gac tac gag ctc ccg gac ggc aaa        926
Leu Val Pro Glu Glu Leu Arg Val Asp Tyr Glu Leu Pro Asp Gly Lys           
            275                 280                 285                   

ctc atc act att ggc cag gag cgc ttc cgt tgc tct gag atg ctc ttc        974
Leu Ile Thr Ile Gly Gln Glu Arg Phe Arg Cys Ser Glu Met Leu Phe           
        290                 295                 300                       

cag ccc tcc ctg gca ggc agc acc cag ccg ggc ctc ccg gag ctc aca       1022
Gln Pro Ser Leu Ala Gly Ser Thr Gln Pro Gly Leu Pro Glu Leu Thr           
    305                 310                 315                           

gct gcc tgc ctg ggc cgc tgc cag gac acg ggc ttc aag gag gag atg       1070
Ala Ala Cys Leu Gly Arg Cys Gln Asp Thr Gly Phe Lys Glu Glu Met           
320                 325                 330                 335           

gcc gcc aac gtg cta ctg tgt ggc ggc tgc act atg ctg gat ggc ttc       1118
Ala Ala Asn Val Leu Leu Cys Gly Gly Cys Thr Met Leu Asp Gly Phe           
                340                 345                 350               

ccc gag cgc ttc cag agg gag ctg agc ctc ctc tgc ccc ggg gac agc       1166
Pro Glu Arg Phe Gln Arg Glu Leu Ser Leu Leu Cys Pro Gly Asp Ser           
            355                 360                 365                   

cct gca gtg gct gcc gct cct gag agg aag acc tcc gtg tgg acc ggc       1214
Pro Ala Val Ala Ala Ala Pro Glu Arg Lys Thr Ser Val Trp Thr Gly           
        370                 375                 380                       

ggt tcc atc ctg gcc tcc ctg cag gcc ttc caa cag ctc tgg gtc agc       1262
Gly Ser Ile Leu Ala Ser Leu Gln Ala Phe Gln Gln Leu Trp Val Ser           
    385                 390                 395                           

aag gaa gag ttt gag gag cgg ggc agc gtg gcc atc tac agc aag tgc       1310
Lys Glu Glu Phe Glu Glu Arg Gly Ser Val Ala Ile Tyr Ser Lys Cys           
400                 405                 410                 415           

tga gcctcggcat ttccacagac aaggcctcca gcacagatgg ccacaggcct            1363

ctctatacac atttacagaa tttcacataa aggtttactc tgaaa                     1408


<210>  682
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  682

Met Ala Thr Arg Asn Ser Pro Met Pro Leu Gly Thr Ala Gln Gly Asp 
1               5                   10                  15      


Pro Gly Glu Ala Gly Thr Arg Pro Gly Pro Asp Ala Ser Leu Arg Asp 
            20                  25                  30          


Thr Gly Ala Ala Thr Gln Leu Lys Met Lys Pro Arg Lys Val His Lys 
        35                  40                  45              


Ile Lys Ala Val Ile Ile Asp Leu Gly Ser Gln Tyr Cys Lys Cys Gly 
    50                  55                  60                  


Tyr Ala Gly Glu Pro Arg Pro Thr Tyr Phe Ile Ser Ser Thr Val Gly 
65                  70                  75                  80  


Lys Arg Cys Pro Glu Ala Ala Asp Ala Gly Asp Thr Arg Lys Trp Thr 
                85                  90                  95      


Leu Val Gly His Glu Leu Leu Asn Thr Glu Ala Pro Leu Lys Leu Val 
            100                 105                 110         


Asn Pro Leu Lys His Gly Ile Val Val Asp Trp Asp Cys Val Gln Asp 
        115                 120                 125             


Ile Trp Glu Tyr Ile Phe Arg Thr Ala Met Lys Ile Leu Pro Glu Glu 
    130                 135                 140                 


His Ala Val Leu Val Ser Asp Pro Pro Leu Ser Pro Ser Ser Asn Arg 
145                 150                 155                 160 


Glu Lys Tyr Ala Glu Leu Met Phe Glu Thr Phe Gly Ile Pro Ala Met 
                165                 170                 175     


His Val Thr Ser Gln Ser Leu Leu Ser Ile Tyr Ser Tyr Gly Lys Thr 
            180                 185                 190         


Ser Gly Leu Val Val Glu Ser Gly His Gly Val Ser His Val Val Pro 
        195                 200                 205             


Ile Ser Glu Gly Asp Val Leu Pro Gly Leu Thr Ser Arg Ala Asp Tyr 
    210                 215                 220                 


Ala Gly Gly Asp Leu Thr Asn Tyr Leu Met Gln Leu Leu Asn Glu Ala 
225                 230                 235                 240 


Gly His Ala Phe Thr Asp Asp His Leu His Ile Ile Glu His Ile Lys 
                245                 250                 255     


Lys Lys Cys Cys Tyr Ala Ala Phe Leu Pro Glu Glu Glu Leu Gly Leu 
            260                 265                 270         


Val Pro Glu Glu Leu Arg Val Asp Tyr Glu Leu Pro Asp Gly Lys Leu 
        275                 280                 285             


Ile Thr Ile Gly Gln Glu Arg Phe Arg Cys Ser Glu Met Leu Phe Gln 
    290                 295                 300                 


Pro Ser Leu Ala Gly Ser Thr Gln Pro Gly Leu Pro Glu Leu Thr Ala 
305                 310                 315                 320 


Ala Cys Leu Gly Arg Cys Gln Asp Thr Gly Phe Lys Glu Glu Met Ala 
                325                 330                 335     


Ala Asn Val Leu Leu Cys Gly Gly Cys Thr Met Leu Asp Gly Phe Pro 
            340                 345                 350         


Glu Arg Phe Gln Arg Glu Leu Ser Leu Leu Cys Pro Gly Asp Ser Pro 
        355                 360                 365             


Ala Val Ala Ala Ala Pro Glu Arg Lys Thr Ser Val Trp Thr Gly Gly 
    370                 375                 380                 


Ser Ile Leu Ala Ser Leu Gln Ala Phe Gln Gln Leu Trp Val Ser Lys 
385                 390                 395                 400 


Glu Glu Phe Glu Glu Arg Gly Ser Val Ala Ile Tyr Ser Lys Cys 
                405                 410                 415 


<210>  683
<211>  2377
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (525)..(1889)

<400>  683
acccccgagc tgtgctgctc gcggccgcca ccgccgggcc ccggccgtcc ctggctcccc       60

tcctgcctcg agaagggcag ggcttctcag aggcttggcg ggaaaaagaa cggagggagg      120

gatcgcgctg agtataaaag ccggttttcg gggctttatc taactcgctg tagtaattcc      180

agcgagaggc agagggagcg agcgggcggc cggctagggt ggaagagccg ggcgagcaga      240

gctgcgctgc gggcgtcctg ggaagggaga tccggagcga atagggggct tcgcctctgg      300

cccagccctc ccgctgatcc cccagccagc ggtccgcaac ccttgccgca tccacgaaac      360

tttgcccata gcagcgggcg ggcactttgc actggaactt acaacacccg agcaaggacg      420

cgactctccc gacgcgggga ggctattctg cccatttggg gacacttccc cgccgctgcc      480

aggacccgct tctctgaaag gctctccttg cagctgctta gacg ctg gat ttt ttt       536
                                                 Leu Asp Phe Phe          
                                                 1                        

cgg gta gtg gaa aac cag cag cct ccc gcg acg atg ccc ctc aac gtt        584
Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met Pro Leu Asn Val           
5                   10                  15                  20            

agc ttc acc aac agg aac tat gac ctc gac tac gac tcg gtg cag ccg        632
Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp Ser Val Gln Pro           
                25                  30                  35                

tat ttc tac tgc gac gag gag gag aac ttc tac cag cag cag cag cag        680
Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln Gln Gln Gln Gln           
            40                  45                  50                    

agc gag ctg cag ccc ccg gcg ccc agc gag gat atc tgg aag aaa ttc        728
Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile Trp Lys Lys Phe           
        55                  60                  65                        

gag ctg ctg ccc acc ccg ccc ctg tcc cct agc cgc cgc tcc ggg ctc        776
Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg Arg Ser Gly Leu           
    70                  75                  80                            

tgc tcg ccc tcc tac gtt gcg gtc aca ccc ttc tcc ctt cgg gga gac        824
Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser Leu Arg Gly Asp           
85                  90                  95                  100           

aac gac ggc ggt ggc ggg agc ttc tcc acg gcc gac cag ctg gag atg        872
Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp Gln Leu Glu Met           
                105                 110                 115               

gtg acc gag ctg ctg gga gga gac atg gtg aac cag agt ttc atc tgc        920
Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln Ser Phe Ile Cys           
            120                 125                 130                   

gac ccg gac gac gag acc ttc atc aaa aac atc atc atc cag gac tgt        968
Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile Ile Gln Asp Cys           
        135                 140                 145                       

atg tgg agc ggc ttc tcg gcc gcc gcc aag ctc gtc tca gag aag ctg       1016
Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val Ser Glu Lys Leu           
    150                 155                 160                           

gcc tcc tac cag gct gcg cgc aaa gac agc ggc agc ccg aac ccc gcc       1064
Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser Pro Asn Pro Ala           
165                 170                 175                 180           

cgc ggc cac agc gtc tgc tcc acc tcc agc ttg tac ctg cag gat ctg       1112
Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr Leu Gln Asp Leu           
                185                 190                 195               

agc gcc gcc gcc tca gag tgc atc gac ccc tcg gtg gtc ttc ccc tac       1160
Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val Val Phe Pro Tyr           
            200                 205                 210                   

cct ctc aac gac agc agc tcg ccc aag tcc tgc gcc tcg caa gac tcc       1208
Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala Ser Gln Asp Ser           
        215                 220                 225                       

agc gcc ttc tct ccg tcc tcg gat tct ctg ctc tcc tcg acg gag tcc       1256
Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser Ser Thr Glu Ser           
    230                 235                 240                           

tcc ccg cag ggc agc ccc gag ccc ctg gtg ctc cat gag gag aca ccg       1304
Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His Glu Glu Thr Pro           
245                 250                 255                 260           

ccc acc acc agc agc gac tct gag gag gaa caa gaa gat gag gaa gaa       1352
Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu Asp Glu Glu Glu           
                265                 270                 275               

atc gat gtt gtt tct gtg gaa aag agg cag gct cct ggc aaa agg tca       1400
Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro Gly Lys Arg Ser           
            280                 285                 290                   

gag tct gga tca cct tct gct gga ggc cac agc aaa cct cct cac agc       1448
Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys Pro Pro His Ser           
        295                 300                 305                       

cca ctg gtc ctc aag agg tgc cac gtc tcc aca cat cag cac aac tac       1496
Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His Gln His Asn Tyr           
    310                 315                 320                           

gca gcg cct ccc tcc act cgg aag gac tat cct gct gcc aag agg gtc       1544
Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala Ala Lys Arg Val           
325                 330                 335                 340           

aag ttg gac agt gtc aga gtc ctg aga cag atc agc aac aac cga aaa       1592
Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser Asn Asn Arg Lys           
                345                 350                 355               

tgc acc agc ccc agg tcc tcg gac acc gag gag aat gtc aag agg cga       1640
Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn Val Lys Arg Arg           
            360                 365                 370                   

aca cac aac gtc ttg gag cgc cag agg agg aac gag cta aaa cgg agc       1688
Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser           
        375                 380                 385                       

ttt ttt gcc ctg cgt gac cag atc ccg gag ttg gaa aac aat gaa aag       1736
Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu Asn Asn Glu Lys           
    390                 395                 400                           

gcc ccc aag gta gtt atc ctt aaa aaa gcc aca gca tac atc ctg tcc       1784
Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala Tyr Ile Leu Ser           
405                 410                 415                 420           

gtc caa gca gag gag caa aag ctc att tct gaa gag gac ttg ttg cgg       1832
Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Arg           
                425                 430                 435               

aaa cga cga gaa cag ttg aaa cac aaa ctt gaa cag cta cgg aac tct       1880
Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln Leu Arg Asn Ser           
            440                 445                 450                   

tgt gcg taa ggaaaagtaa ggaaaacgat tccttctaac agaaatgtcc               1929
Cys Ala                                                                   
                                                                          

tgagcaatca cctatgaact tgtttcaaat gcatgatcaa atgcaacctc acaaccttgg     1989

ctgagtcttg agactgaaag atttagccat aatgtaaact gcctcaaatt ggactttggg     2049

cataaaagaa cttttttatg cttaccatct tttttttttc tttaacagat ttgtatttaa     2109

gaattgtttt taaaaaattt taagatttac acaatgtttc tctgtaaata ttgccattaa     2169

atgtaaataa ctttaataaa acgtttatag cagttacaca gaatttcaat cctagtatat     2229

agtacctagt attataggta ctataaaccc taattttttt tatttaagta cattttgctt     2289

tttaaagttg atttttttct attgttttta gaaaaaataa aataactggc aaatatatca     2349

ttgagccaaa aaaaaaaaaa aaaaaaaa                                        2377


<210>  684
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  684

Leu Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


<210>  685
<211>  3230
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (838)..(2517)

<400>  685
agcagtgttc tcttcgtccc cctcccccaa actgaggatt gggcaatacc acagaacctc       60

aggaaagggg ggaagagcga gcttcggccc cactaatggg ggagtgggcg gaggctggat      120

ttcccacctc ggctgcacct gggcactgga ggctgaagag gaaagtgaga atctgaagtt      180

ttgagacctc tgactggcca ggaatagctc ctggggcggg gggcaaggat gggaccatag      240

gcggaaagag tctcgcggtc ccccctgctt ctggcgcggg tccctgcgcc cggttgtgga      300

gcgtctcgcg cggggagggg gcggggggaa cggcagctcg cggtgttgtt cactcgcgcg      360

tcgagcacac ggtgggtccg gcggcgggtt ggcgccccag gcggcgttcc ctgtggcctg      420

gcgcctgggc cgctgccctg agcgggttcc gccccagagc ccgaccctcc tgggggctct      480

aggcggagtc ccgcgagccg agggggaccg gcgaccgctg ccgaagcatg aagaaggggt      540

aaggcgtgag cccccaagat ttcacgcatg ccccctagct tcggtactct gacaccttct      600

cttgcacttg cggatgatga actggaataa cgatgaaaga aagcacatcc gatctcaaca      660

ttcacgtcct gccctataac cgattaatta attgatcccc agctagacta gtgttggaga      720

aatcagcatg ttaaaacaac tgttgatgat agctgttgga gtaaagttgc agtggaagct      780

atggctgcaa aatcgttaaa atcttcaagg tgaactggca caaaggttaa tctcaag         837

atg ccg cta gtg aaa aga aac atc gat cct agg cac ttg tgc cac aca        885
Met Pro Leu Val Lys Arg Asn Ile Asp Pro Arg His Leu Cys His Thr           
1               5                   10                  15                

gca ctg cct aga ggc att aag aat gaa ctg gaa tgt gta acc aat att        933
Ala Leu Pro Arg Gly Ile Lys Asn Glu Leu Glu Cys Val Thr Asn Ile           
            20                  25                  30                    

tcc ttg gca aat ata att aga caa cta agt agc cta agt aaa tat gct        981
Ser Leu Ala Asn Ile Ile Arg Gln Leu Ser Ser Leu Ser Lys Tyr Ala           
        35                  40                  45                        

gaa gat ata ttt gga gaa tta ttc aat gaa gca cat agt ttt tcc ttc       1029
Glu Asp Ile Phe Gly Glu Leu Phe Asn Glu Ala His Ser Phe Ser Phe           
    50                  55                  60                            

aga gtc aac tca ttg caa gaa cgt gtg gac cgt tta tct gtt agt gtt       1077
Arg Val Asn Ser Leu Gln Glu Arg Val Asp Arg Leu Ser Val Ser Val           
65                  70                  75                  80            

aca cag ctt gat cca aag gaa gaa gaa ttg tct ttg caa gat ata aca       1125
Thr Gln Leu Asp Pro Lys Glu Glu Glu Leu Ser Leu Gln Asp Ile Thr           
                85                  90                  95                

atg agg aaa gct ttc cga agt tct aca att caa gac cag cag ctt ttc       1173
Met Arg Lys Ala Phe Arg Ser Ser Thr Ile Gln Asp Gln Gln Leu Phe           
            100                 105                 110                   

gat cgc aag act ttg cct att cca tta cag gag acg tac gat gtt tgt       1221
Asp Arg Lys Thr Leu Pro Ile Pro Leu Gln Glu Thr Tyr Asp Val Cys           
        115                 120                 125                       

gaa cag cct cca cct ctc aat ata ctc act cct tat aga gat gat ggt       1269
Glu Gln Pro Pro Pro Leu Asn Ile Leu Thr Pro Tyr Arg Asp Asp Gly           
    130                 135                 140                           

aaa gaa ggt ctg aag ttt tat acc aat cct tcg tat ttc ttt gat cta       1317
Lys Glu Gly Leu Lys Phe Tyr Thr Asn Pro Ser Tyr Phe Phe Asp Leu           
145                 150                 155                 160           

tgg aaa gaa aaa atg ttg caa gat aca gag gat aag agg aag gaa aag       1365
Trp Lys Glu Lys Met Leu Gln Asp Thr Glu Asp Lys Arg Lys Glu Lys           
                165                 170                 175               

agg aag cag aag cag aaa aat cta gat cgt cct cat gaa cca gaa aaa       1413
Arg Lys Gln Lys Gln Lys Asn Leu Asp Arg Pro His Glu Pro Glu Lys           
            180                 185                 190                   

gtg cca aga gca cct cat gac agg cgg cga gaa tgg cag aag ctg gcc       1461
Val Pro Arg Ala Pro His Asp Arg Arg Arg Glu Trp Gln Lys Leu Ala           
        195                 200                 205                       

caa ggt cca gag ctg gct gaa gat gat gct aat ctc tta cat aag cat       1509
Gln Gly Pro Glu Leu Ala Glu Asp Asp Ala Asn Leu Leu His Lys His           
    210                 215                 220                           

att gaa gtt gct aat ggc cca gcc tct cat ttt gaa aca aga cct cag       1557
Ile Glu Val Ala Asn Gly Pro Ala Ser His Phe Glu Thr Arg Pro Gln           
225                 230                 235                 240           

aca tac gtg gat cat atg gat gga tct tac tca ctt tct gcc ttg cca       1605
Thr Tyr Val Asp His Met Asp Gly Ser Tyr Ser Leu Ser Ala Leu Pro           
                245                 250                 255               

ttt agt cag atg agt gag ctt ctg act aga gct gag gaa agg gta tta       1653
Phe Ser Gln Met Ser Glu Leu Leu Thr Arg Ala Glu Glu Arg Val Leu           
            260                 265                 270                   

gtc aga cca cat gaa cca cct cca cct cca cca atg cat gga gca gga       1701
Val Arg Pro His Glu Pro Pro Pro Pro Pro Pro Met His Gly Ala Gly           
        275                 280                 285                       

gat gca aaa ccg ata ccc acc tgt atc agt tct gct aca ggt ttg ata       1749
Asp Ala Lys Pro Ile Pro Thr Cys Ile Ser Ser Ala Thr Gly Leu Ile           
    290                 295                 300                           

gaa aat cgc cct cag tca cca gct aca ggc aga aca cct gtg ttt gtg       1797
Glu Asn Arg Pro Gln Ser Pro Ala Thr Gly Arg Thr Pro Val Phe Val           
305                 310                 315                 320           

agc ccc act ccc cca cct cct cca cca cct ctt cca tct gcc ttg tca       1845
Ser Pro Thr Pro Pro Pro Pro Pro Pro Pro Leu Pro Ser Ala Leu Ser           
                325                 330                 335               

act tcc tca tta aga gct tca atg act tca act cct ccc cct cca gta       1893
Thr Ser Ser Leu Arg Ala Ser Met Thr Ser Thr Pro Pro Pro Pro Val           
            340                 345                 350                   

cct ccc cca cct cca cct cca gcc act gct ttg caa gct cca gca gta       1941
Pro Pro Pro Pro Pro Pro Pro Ala Thr Ala Leu Gln Ala Pro Ala Val           
        355                 360                 365                       

cca cca cct cca gct cct ctt cag att gcc cct gga gtt ctt cac cca       1989
Pro Pro Pro Pro Ala Pro Leu Gln Ile Ala Pro Gly Val Leu His Pro           
    370                 375                 380                           

gct cct cct cca att gca cct cct cta gta cag ccc tct cca cca gta       2037
Ala Pro Pro Pro Ile Ala Pro Pro Leu Val Gln Pro Ser Pro Pro Val           
385                 390                 395                 400           

gct aga gct gcc cca gta tgt gag act gta cca gtt cat cca ctc cca       2085
Ala Arg Ala Ala Pro Val Cys Glu Thr Val Pro Val His Pro Leu Pro           
                405                 410                 415               

caa ggt gaa gtt cag ggg ctg cct cca ccc cca cca ccg cct cct ctg       2133
Gln Gly Glu Val Gln Gly Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu           
            420                 425                 430                   

cct cca cct ggc att cga cca tca tca cct gtc aca gtt aca gct ctt       2181
Pro Pro Pro Gly Ile Arg Pro Ser Ser Pro Val Thr Val Thr Ala Leu           
        435                 440                 445                       

gct cat cct ccc tct ggg cta cat cca act cca tct act gcc cca ggt       2229
Ala His Pro Pro Ser Gly Leu His Pro Thr Pro Ser Thr Ala Pro Gly           
    450                 455                 460                           

ccc cat gtt cca tta atg cct cca tct cct cca tca caa gtt ata cct       2277
Pro His Val Pro Leu Met Pro Pro Ser Pro Pro Ser Gln Val Ile Pro           
465                 470                 475                 480           

gct tct gag cca aag cgc cat cca tca acc cta cct gta atc agt gat       2325
Ala Ser Glu Pro Lys Arg His Pro Ser Thr Leu Pro Val Ile Ser Asp           
                485                 490                 495               

gcc agg agt gtg cta ctg gaa gca ata cga aaa ggt att cag cta cgc       2373
Ala Arg Ser Val Leu Leu Glu Ala Ile Arg Lys Gly Ile Gln Leu Arg           
            500                 505                 510                   

aaa gta gaa gag cag cgt gaa cag gaa gct aag cat gaa cgc att gaa       2421
Lys Val Glu Glu Gln Arg Glu Gln Glu Ala Lys His Glu Arg Ile Glu           
        515                 520                 525                       

aac gat gtt gcc acc atc ctg tct cgc cgt att gct gtt gaa tat agt       2469
Asn Asp Val Ala Thr Ile Leu Ser Arg Arg Ile Ala Val Glu Tyr Ser           
    530                 535                 540                           

gat tcg gaa gat gat tca gaa ttt gat gaa gta gat tgg ttg gag taa       2517
Asp Ser Glu Asp Asp Ser Glu Phe Asp Glu Val Asp Trp Leu Glu               
545                 550                 555                               

gaaaaatgca ttgataaata ttacaaaact gaatgcaaat gtcctttgtg gtgcttgttc     2577

cttgaaaatg tttggtcatt ctagtgtttt gctttctttt ccttataata aatgaccctt     2637

ttcctccata acttttgatt tctaaggaaa atattagcat acatttcaaa ctaaatgttt     2697

tacagtggct tatctttttt ttccccctga aaagactaat ttggtcaaat aaaccactaa     2757

gtattaagca tggacagctg ttgttagagt agcagattca gttttttgat atatcttaat     2817

tgtgtacttt gtgaatttta atttaaagaa agcaactgaa attgaaatct tgagggcagc     2877

tgtgtctact aatgagcctt attccatttc ctgatgtttt aaaagaagaa acactgcctt     2937

gattatacga atacactcag aaagtacatt tagcttgtag tgttgaattc tcttaaagga     2997

atgcttgaat tttttcatta ttgttttatt gtttttatat acttgcctta tttgaatgtt     3057

tagcagtatc cccttcccac ttatatattg tgtgatatga ttttgcttgc ctataggagt     3117

taaaaacttt tccatgtgaa atactctgac ttaaacatac atgtaactta cataactgtt     3177

aagaataaca gtctgattta ataaatggtt cattttaaaa gttaaaaaaa aaa            3230


<210>  686
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  686

Met Pro Leu Val Lys Arg Asn Ile Asp Pro Arg His Leu Cys His Thr 
1               5                   10                  15      


Ala Leu Pro Arg Gly Ile Lys Asn Glu Leu Glu Cys Val Thr Asn Ile 
            20                  25                  30          


Ser Leu Ala Asn Ile Ile Arg Gln Leu Ser Ser Leu Ser Lys Tyr Ala 
        35                  40                  45              


Glu Asp Ile Phe Gly Glu Leu Phe Asn Glu Ala His Ser Phe Ser Phe 
    50                  55                  60                  


Arg Val Asn Ser Leu Gln Glu Arg Val Asp Arg Leu Ser Val Ser Val 
65                  70                  75                  80  


Thr Gln Leu Asp Pro Lys Glu Glu Glu Leu Ser Leu Gln Asp Ile Thr 
                85                  90                  95      


Met Arg Lys Ala Phe Arg Ser Ser Thr Ile Gln Asp Gln Gln Leu Phe 
            100                 105                 110         


Asp Arg Lys Thr Leu Pro Ile Pro Leu Gln Glu Thr Tyr Asp Val Cys 
        115                 120                 125             


Glu Gln Pro Pro Pro Leu Asn Ile Leu Thr Pro Tyr Arg Asp Asp Gly 
    130                 135                 140                 


Lys Glu Gly Leu Lys Phe Tyr Thr Asn Pro Ser Tyr Phe Phe Asp Leu 
145                 150                 155                 160 


Trp Lys Glu Lys Met Leu Gln Asp Thr Glu Asp Lys Arg Lys Glu Lys 
                165                 170                 175     


Arg Lys Gln Lys Gln Lys Asn Leu Asp Arg Pro His Glu Pro Glu Lys 
            180                 185                 190         


Val Pro Arg Ala Pro His Asp Arg Arg Arg Glu Trp Gln Lys Leu Ala 
        195                 200                 205             


Gln Gly Pro Glu Leu Ala Glu Asp Asp Ala Asn Leu Leu His Lys His 
    210                 215                 220                 


Ile Glu Val Ala Asn Gly Pro Ala Ser His Phe Glu Thr Arg Pro Gln 
225                 230                 235                 240 


Thr Tyr Val Asp His Met Asp Gly Ser Tyr Ser Leu Ser Ala Leu Pro 
                245                 250                 255     


Phe Ser Gln Met Ser Glu Leu Leu Thr Arg Ala Glu Glu Arg Val Leu 
            260                 265                 270         


Val Arg Pro His Glu Pro Pro Pro Pro Pro Pro Met His Gly Ala Gly 
        275                 280                 285             


Asp Ala Lys Pro Ile Pro Thr Cys Ile Ser Ser Ala Thr Gly Leu Ile 
    290                 295                 300                 


Glu Asn Arg Pro Gln Ser Pro Ala Thr Gly Arg Thr Pro Val Phe Val 
305                 310                 315                 320 


Ser Pro Thr Pro Pro Pro Pro Pro Pro Pro Leu Pro Ser Ala Leu Ser 
                325                 330                 335     


Thr Ser Ser Leu Arg Ala Ser Met Thr Ser Thr Pro Pro Pro Pro Val 
            340                 345                 350         


Pro Pro Pro Pro Pro Pro Pro Ala Thr Ala Leu Gln Ala Pro Ala Val 
        355                 360                 365             


Pro Pro Pro Pro Ala Pro Leu Gln Ile Ala Pro Gly Val Leu His Pro 
    370                 375                 380                 


Ala Pro Pro Pro Ile Ala Pro Pro Leu Val Gln Pro Ser Pro Pro Val 
385                 390                 395                 400 


Ala Arg Ala Ala Pro Val Cys Glu Thr Val Pro Val His Pro Leu Pro 
                405                 410                 415     


Gln Gly Glu Val Gln Gly Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu 
            420                 425                 430         


Pro Pro Pro Gly Ile Arg Pro Ser Ser Pro Val Thr Val Thr Ala Leu 
        435                 440                 445             


Ala His Pro Pro Ser Gly Leu His Pro Thr Pro Ser Thr Ala Pro Gly 
    450                 455                 460                 


Pro His Val Pro Leu Met Pro Pro Ser Pro Pro Ser Gln Val Ile Pro 
465                 470                 475                 480 


Ala Ser Glu Pro Lys Arg His Pro Ser Thr Leu Pro Val Ile Ser Asp 
                485                 490                 495     


Ala Arg Ser Val Leu Leu Glu Ala Ile Arg Lys Gly Ile Gln Leu Arg 
            500                 505                 510         


Lys Val Glu Glu Gln Arg Glu Gln Glu Ala Lys His Glu Arg Ile Glu 
        515                 520                 525             


Asn Asp Val Ala Thr Ile Leu Ser Arg Arg Ile Ala Val Glu Tyr Ser 
    530                 535                 540                 


Asp Ser Glu Asp Asp Ser Glu Phe Asp Glu Val Asp Trp Leu Glu 
545                 550                 555                 


<210>  687
<211>  1516
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (56)..(502)

<400>  687
aaatactggg gccagctcac cctggtcagc ctagcactct gacctagcag tcaac atg        58
                                                             Met          
                                                             1            

aag gct ctc att gtt ctg ggg ctt gtc ctc ctt tct gtt acg gtc cag        106
Lys Ala Leu Ile Val Leu Gly Leu Val Leu Leu Ser Val Thr Val Gln           
            5                   10                  15                    

ggc aag gtc ttt gaa agg tgt gag ttg gcc aga act ctg aaa aga ttg        154
Gly Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg Leu           
        20                  25                  30                        

gga atg gat ggc tac agg gga atc agc cta gca aac tgg atg tgt ttg        202
Gly Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys Leu           
    35                  40                  45                            

gcc aaa tgg gag agt ggt tac aac aca cga gct aca aac tac aat gct        250
Ala Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn Ala           
50                  55                  60                  65            

gga gac aga agc act gat tat ggg ata ttt cag atc aat agc cgc tac        298
Gly Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg Tyr           
                70                  75                  80                

tgg tgt aat gat ggc aaa acc cca gga gca gtt aat gcc tgt cat tta        346
Trp Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys His Leu           
            85                  90                  95                    

tcc tgc agt gct ttg ctg caa gat aac atc gct gat gct gta gct tgt        394
Ser Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala Cys           
        100                 105                 110                       

gca aag agg gtt gtc cgt gat cca caa ggc att aga gca tgg gtg gca        442
Ala Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val Ala           
    115                 120                 125                           

tgg aga aat cgt tgt caa aac aga gat gtc cgt cag tat gtt caa ggt        490
Trp Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln Gly           
130                 135                 140                 145           

tgt gga gtg taa ctccagaatt ttccttcttc agctcatttt gtctctctca            542
Cys Gly Val                                                               
                                                                          

cattaaggga gtaggaatta agtgaaaggt cacactacca ttatttcccc ttcaaacaaa      602

taatattttt acagaagcag gagcaaaata tggcctttct tctaagagat ataatgttca      662

ctaatgtggt tattttacat taagcctaca acatttttca gtttgcaaat agaactaata      722

ctggtgaaaa tttacctaaa accttggtta tcaaatacat ctccagtaca ttccgttctt      782

tttttttttg agacagtctc gctctgtcgc ccaggctgga gtgcagtggc gcaatctcgg      842

ctcactgcaa cctccacctc ccgggttcac gccattctcc tgcctcagcc tcccgagtag      902

ctgggattac gggcgcccgc caccacgccc ggctaatttt ttgtattttt agtagagaca      962

gggtttcacc gtgttagcca ggatggtctc gatctcctga ccttgtgatc cacccacctc     1022

ggcctcccaa agtgctggga ttacaggcgt gagccactgc gcccggccac attcagttct     1082

tatcaaagaa ataacccaga cttaatcttg aatgatacga ttatgcccaa tattaagtaa     1142

aaaatataag aaaaggttat cttaaataga tcttaggcaa aataccagct gatgaaggca     1202

tctgatgcct tcatctgttc agtcatctcc aaaaacagta aaaataacca ctttttgttg     1262

ggcaatatga aatttttaaa ggagtagaat accaaatgat agaaacagac tgcctgaatt     1322

gagaattttg atttcttaaa gtgtgtttct ttctaaattg ctgttcctta atttgattaa     1382

tttaattcat gtattatgat taaatctgag gcagatgagc ttacaagtat tgaaataatt     1442

actaattaat cacaaatgtg aagttatgca tgatgtaaaa aatacaaaca ttctaattaa     1502

aggctttgca acac                                                       1516


<210>  688
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  688

Met Lys Ala Leu Ile Val Leu Gly Leu Val Leu Leu Ser Val Thr Val 
1               5                   10                  15      


Gln Gly Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg 
            20                  25                  30          


Leu Gly Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys 
        35                  40                  45              


Leu Ala Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn 
    50                  55                  60                  


Ala Gly Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg 
65                  70                  75                  80  


Tyr Trp Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys His 
                85                  90                  95      


Leu Ser Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala 
            100                 105                 110         


Cys Ala Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val 
        115                 120                 125             


Ala Trp Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln 
    130                 135                 140                 


Gly Cys Gly Val 
145             


<210>  689
<211>  2770
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (88)..(1596)

<400>  689
gaccggggtc ggggcagggg gcggggccga gcgggagacc agagagccgg agccggatcc       60

cgatcccgag tccgagccgc cgccgcc atg agc tgc ccc gtg ccc gcc tgc tgc      114
                              Met Ser Cys Pro Val Pro Ala Cys Cys         
                              1               5                           

gcg ctg ctg cta gtc ctg ggg ctc tgc cgg gcg cgt ccc cgg aac gca        162
Ala Leu Leu Leu Val Leu Gly Leu Cys Arg Ala Arg Pro Arg Asn Ala           
10                  15                  20                  25            

ctg ctg ctc ctc gcg gat gac gga ggc ttt gag agt ggc gcg tac aac        210
Leu Leu Leu Leu Ala Asp Asp Gly Gly Phe Glu Ser Gly Ala Tyr Asn           
                30                  35                  40                

aac agc gcc atc gcc acc ccg cac ctg gac gcc ttg gcc cgc cgc agc        258
Asn Ser Ala Ile Ala Thr Pro His Leu Asp Ala Leu Ala Arg Arg Ser           
            45                  50                  55                    

ctc ctc ttt cgc aat gcc ttc acc tcg gtc agc agc tgc tct ccc agc        306
Leu Leu Phe Arg Asn Ala Phe Thr Ser Val Ser Ser Cys Ser Pro Ser           
        60                  65                  70                        

cgc gcc agc ctc ctc act ggc ctg ccc cag cat cag aat ggg atg tac        354
Arg Ala Ser Leu Leu Thr Gly Leu Pro Gln His Gln Asn Gly Met Tyr           
    75                  80                  85                            

ggg ctg cac cag gac gtg cac cac ttc aac tcc ttc gac aag gtg cgg        402
Gly Leu His Gln Asp Val His His Phe Asn Ser Phe Asp Lys Val Arg           
90                  95                  100                 105           

agc ctg ccg ctg ctg ctc agc caa gct ggt gtg cgc aca ggc atc atc        450
Ser Leu Pro Leu Leu Leu Ser Gln Ala Gly Val Arg Thr Gly Ile Ile           
                110                 115                 120               

ggg aag aag cac gtg ggg ccg gag acc gtg tac ccg ttt gac ttt gcg        498
Gly Lys Lys His Val Gly Pro Glu Thr Val Tyr Pro Phe Asp Phe Ala           
            125                 130                 135                   

tac acg gag gag aat ggc tcc gtc ctc cag gtg ggg cgg aac atc act        546
Tyr Thr Glu Glu Asn Gly Ser Val Leu Gln Val Gly Arg Asn Ile Thr           
        140                 145                 150                       

aga att aag ctg ctc gtc cgg aaa ttc ctg cag act cag gat gac cgg        594
Arg Ile Lys Leu Leu Val Arg Lys Phe Leu Gln Thr Gln Asp Asp Arg           
    155                 160                 165                           

cct ttc ttc ctc tac gtc gcc ttc cac gac ccc cac cgc tgt ggg cac        642
Pro Phe Phe Leu Tyr Val Ala Phe His Asp Pro His Arg Cys Gly His           
170                 175                 180                 185           

tcc cag ccc cag tac gga acc ttc tgt gag aag ttt ggc aac gga gag        690
Ser Gln Pro Gln Tyr Gly Thr Phe Cys Glu Lys Phe Gly Asn Gly Glu           
                190                 195                 200               

agc ggc atg ggt cgt atc cca gac tgg acc ccc cag gcc tac gac cca        738
Ser Gly Met Gly Arg Ile Pro Asp Trp Thr Pro Gln Ala Tyr Asp Pro           
            205                 210                 215                   

ctg gac gtg ctg gtg cct tac ttc gtc ccc aac acc ccg gca gcc cga        786
Leu Asp Val Leu Val Pro Tyr Phe Val Pro Asn Thr Pro Ala Ala Arg           
        220                 225                 230                       

gcc gac ctg gcc gct cag tac acc acc gtc ggc cgc atg gac caa gga        834
Ala Asp Leu Ala Ala Gln Tyr Thr Thr Val Gly Arg Met Asp Gln Gly           
    235                 240                 245                           

gtt gga ctg gtg ctc cag gag ctg cgt gac gcc ggt gtc ctg aac gac        882
Val Gly Leu Val Leu Gln Glu Leu Arg Asp Ala Gly Val Leu Asn Asp           
250                 255                 260                 265           

aca ctg gtg atc ttc acg tcc gac aac ggg atc ccc ttc ccc agc ggc        930
Thr Leu Val Ile Phe Thr Ser Asp Asn Gly Ile Pro Phe Pro Ser Gly           
                270                 275                 280               

agg acc aac ctg tac tgg ccg ggc act gct gaa ccc tta ctg gtg tca        978
Arg Thr Asn Leu Tyr Trp Pro Gly Thr Ala Glu Pro Leu Leu Val Ser           
            285                 290                 295                   

tcc ccg gag cac cca aaa cgc tgg ggc caa gtc agc gag gcc tac gtg       1026
Ser Pro Glu His Pro Lys Arg Trp Gly Gln Val Ser Glu Ala Tyr Val           
        300                 305                 310                       

agc ctc cta gac ctc acg ccc acc atc ttg gat tgg ttc tcg atc ccg       1074
Ser Leu Leu Asp Leu Thr Pro Thr Ile Leu Asp Trp Phe Ser Ile Pro           
    315                 320                 325                           

tac ccc agc tac gcc atc ttt ggc tcg aag acc atc cac ctc act ggc       1122
Tyr Pro Ser Tyr Ala Ile Phe Gly Ser Lys Thr Ile His Leu Thr Gly           
330                 335                 340                 345           

cgg tcc ctc ctg ccg gcg ctg gag gcc gag ccc ctc tgg gcc acc gtc       1170
Arg Ser Leu Leu Pro Ala Leu Glu Ala Glu Pro Leu Trp Ala Thr Val           
                350                 355                 360               

ttt ggc agc cag agc cac cac gag gtc acc atg tcc tac ccc atg cgc       1218
Phe Gly Ser Gln Ser His His Glu Val Thr Met Ser Tyr Pro Met Arg           
            365                 370                 375                   

tcc gtg cag cac cgg cac ttc cgc ctc gtg cac aac ctc aac ttc aag       1266
Ser Val Gln His Arg His Phe Arg Leu Val His Asn Leu Asn Phe Lys           
        380                 385                 390                       

atg ccc ttt ccc atc gac cag gac ttc tac gtc tca ccc acc ttc cag       1314
Met Pro Phe Pro Ile Asp Gln Asp Phe Tyr Val Ser Pro Thr Phe Gln           
    395                 400                 405                           

gac ctc ctg aac cgc acc aca gct ggt cag ccc acg ggc tgg tac aag       1362
Asp Leu Leu Asn Arg Thr Thr Ala Gly Gln Pro Thr Gly Trp Tyr Lys           
410                 415                 420                 425           

gac ctc cgt cat tac tac tac cgg gcg cgc tgg gag ctc tac gac cgg       1410
Asp Leu Arg His Tyr Tyr Tyr Arg Ala Arg Trp Glu Leu Tyr Asp Arg           
                430                 435                 440               

agc cgg gac ccc cac gag acc cag aac ctg gcc acc gac ccg cgc ttt       1458
Ser Arg Asp Pro His Glu Thr Gln Asn Leu Ala Thr Asp Pro Arg Phe           
            445                 450                 455                   

gct cag ctt ctg gag atg ctt cgg gac cag ctg gcc aag tgg cag tgg       1506
Ala Gln Leu Leu Glu Met Leu Arg Asp Gln Leu Ala Lys Trp Gln Trp           
        460                 465                 470                       

gag acc cac gac ccc tgg gtg tgc gcc ccc gac ggc gtc ctg gag gag       1554
Glu Thr His Asp Pro Trp Val Cys Ala Pro Asp Gly Val Leu Glu Glu           
    475                 480                 485                           

aag ctc tct ccc cag tgc cag ccc ctc cac aat gag ctg tga               1596
Lys Leu Ser Pro Gln Cys Gln Pro Leu His Asn Glu Leu                       
490                 495                 500                               

ccatcccagg aggcctgtgc acacatccca ggcatgtccc agacacatcc cacacgtgtc     1656

cgtgtggccg gccagcctgg ggagtagtgg caacagccct tccgtccaca ctcccatcca     1716

aggagggttc ttccttcctg tggggtcact cttgccattg cctggagggg gaccagagca     1776

tgtgaccaga gcatgtgccc agcccctcca ccaccagggg cactgccgtc atggcagggg     1836

acacagttgt ccttgtgtct gaaccatgtc ccagcacggg aattctagac atacgtggtc     1896

tgcggacagg gcagcgcccc cagcccatga caagggagtc ttgttttctg gcttggtttg     1956

gggacctgca aatgggaggc ctgaggccct cttcaggctt tggcagccac agatacttct     2016

gaacccttca cagagagcag gcaggggctt cggtgccgcg tgggcagtac gcaggtccca     2076

ccgacactca cctgggagca cggcgcctgg ctcttaccag cgtctggcct agaggaagcc     2136

tttgagcgac ctttgggcag gtttctgctt cttctgtttt gccccatggt caagtccctg     2196

ttccccaggc aggtttcagc tgattggcag caggctccct gagtgatgag cttgaacctg     2256

tggtgtttct gggcagaagc ttatcttttt tgagagtgtc cgaagatgaa ggcatggcga     2316

tgcccgtcct ctggcttggg ttaattcttc ggtgacactg gcattgctgg gtggtgatgc     2376

ccgtcctctg gcttgggtta attcttcggt gacactggcg ttgctgggtg gcaatgccca     2436

tcctctgcct tgggttaatt cttcggtgac actggcgttg ctgggtggcg atgcccgtcc     2496

tctggcttgg gttaattctt ggatgacgtc ggcgttgctg ggagaatgtg ccgttcctgc     2556

cctgcctcca cccacctcgg gagcagaagc ccggcctgga cacccctcgg cctggacacc     2616

cctcgaagga gagggcgctt ccttgagtag gtgggctccc cttgcccttc cctccctatc     2676

actccatact ggggtgggct ggaggaggcc acaggccagc tattgtaaaa gctttttatt     2736

ttagtaaaat atacagaagt tctttttctg aaaa                                 2770


<210>  690
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  690

Met Ser Cys Pro Val Pro Ala Cys Cys Ala Leu Leu Leu Val Leu Gly 
1               5                   10                  15      


Leu Cys Arg Ala Arg Pro Arg Asn Ala Leu Leu Leu Leu Ala Asp Asp 
            20                  25                  30          


Gly Gly Phe Glu Ser Gly Ala Tyr Asn Asn Ser Ala Ile Ala Thr Pro 
        35                  40                  45              


His Leu Asp Ala Leu Ala Arg Arg Ser Leu Leu Phe Arg Asn Ala Phe 
    50                  55                  60                  


Thr Ser Val Ser Ser Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly 
65                  70                  75                  80  


Leu Pro Gln His Gln Asn Gly Met Tyr Gly Leu His Gln Asp Val His 
                85                  90                  95      


His Phe Asn Ser Phe Asp Lys Val Arg Ser Leu Pro Leu Leu Leu Ser 
            100                 105                 110         


Gln Ala Gly Val Arg Thr Gly Ile Ile Gly Lys Lys His Val Gly Pro 
        115                 120                 125             


Glu Thr Val Tyr Pro Phe Asp Phe Ala Tyr Thr Glu Glu Asn Gly Ser 
    130                 135                 140                 


Val Leu Gln Val Gly Arg Asn Ile Thr Arg Ile Lys Leu Leu Val Arg 
145                 150                 155                 160 


Lys Phe Leu Gln Thr Gln Asp Asp Arg Pro Phe Phe Leu Tyr Val Ala 
                165                 170                 175     


Phe His Asp Pro His Arg Cys Gly His Ser Gln Pro Gln Tyr Gly Thr 
            180                 185                 190         


Phe Cys Glu Lys Phe Gly Asn Gly Glu Ser Gly Met Gly Arg Ile Pro 
        195                 200                 205             


Asp Trp Thr Pro Gln Ala Tyr Asp Pro Leu Asp Val Leu Val Pro Tyr 
    210                 215                 220                 


Phe Val Pro Asn Thr Pro Ala Ala Arg Ala Asp Leu Ala Ala Gln Tyr 
225                 230                 235                 240 


Thr Thr Val Gly Arg Met Asp Gln Gly Val Gly Leu Val Leu Gln Glu 
                245                 250                 255     


Leu Arg Asp Ala Gly Val Leu Asn Asp Thr Leu Val Ile Phe Thr Ser 
            260                 265                 270         


Asp Asn Gly Ile Pro Phe Pro Ser Gly Arg Thr Asn Leu Tyr Trp Pro 
        275                 280                 285             


Gly Thr Ala Glu Pro Leu Leu Val Ser Ser Pro Glu His Pro Lys Arg 
    290                 295                 300                 


Trp Gly Gln Val Ser Glu Ala Tyr Val Ser Leu Leu Asp Leu Thr Pro 
305                 310                 315                 320 


Thr Ile Leu Asp Trp Phe Ser Ile Pro Tyr Pro Ser Tyr Ala Ile Phe 
                325                 330                 335     


Gly Ser Lys Thr Ile His Leu Thr Gly Arg Ser Leu Leu Pro Ala Leu 
            340                 345                 350         


Glu Ala Glu Pro Leu Trp Ala Thr Val Phe Gly Ser Gln Ser His His 
        355                 360                 365             


Glu Val Thr Met Ser Tyr Pro Met Arg Ser Val Gln His Arg His Phe 
    370                 375                 380                 


Arg Leu Val His Asn Leu Asn Phe Lys Met Pro Phe Pro Ile Asp Gln 
385                 390                 395                 400 


Asp Phe Tyr Val Ser Pro Thr Phe Gln Asp Leu Leu Asn Arg Thr Thr 
                405                 410                 415     


Ala Gly Gln Pro Thr Gly Trp Tyr Lys Asp Leu Arg His Tyr Tyr Tyr 
            420                 425                 430         


Arg Ala Arg Trp Glu Leu Tyr Asp Arg Ser Arg Asp Pro His Glu Thr 
        435                 440                 445             


Gln Asn Leu Ala Thr Asp Pro Arg Phe Ala Gln Leu Leu Glu Met Leu 
    450                 455                 460                 


Arg Asp Gln Leu Ala Lys Trp Gln Trp Glu Thr His Asp Pro Trp Val 
465                 470                 475                 480 


Cys Ala Pro Asp Gly Val Leu Glu Glu Lys Leu Ser Pro Gln Cys Gln 
                485                 490                 495     


Pro Leu His Asn Glu Leu 
            500         


<210>  691
<211>  938
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (137)..(580)

<400>  691
gttgactaag tcaataatca gaatcagcag gtttgcagtc agattggcag ggataagcag       60

cctagctcag gagaagtgag tataaaagcc ccaggctggg agcagccatc acagaagtcc      120

actcattctt ggcagg atg gct tct cat cgt ctg ctc ctc ctc tgc ctt gct      172
                  Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala         
                  1               5                   10                  

gga ctg gta ttt gtg tct gag gct ggc cct acg ggc acc ggt gaa tcc        220
Gly Leu Val Phe Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser           
        15                  20                  25                        

aag tgt cct ctg atg gtc aaa gtt cta gat gct gtc cga ggc agt cct        268
Lys Cys Pro Leu Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro           
    30                  35                  40                            

gcc atc aat gtg gcc gtg cat gtg ttc aga aag gct gct gat gac acc        316
Ala Ile Asn Val Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr           
45                  50                  55                  60            

tgg gag cca ttt gcc tct ggg aaa acc agt gag tct gga gag ctg cat        364
Trp Glu Pro Phe Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His           
                65                  70                  75                

ggg ctc aca act gag gag gaa ttt gta gaa ggg ata tac aaa gtg gaa        412
Gly Leu Thr Thr Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu           
            80                  85                  90                    

ata gac acc aaa tct tac tgg aag gca ctt ggc atc tcc cca ttc cat        460
Ile Asp Thr Lys Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His           
        95                  100                 105                       

gag cat gca gag gtg gta ttc aca gcc aac gac tcc ggc ccc cgc cgc        508
Glu His Ala Glu Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg           
    110                 115                 120                           

tac acc att gcc gcc ctg ctg agc ccc tac tcc tat tcc acc acg gct        556
Tyr Thr Ile Ala Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala           
125                 130                 135                 140           

gtc gtc acc aat ccc aag gaa tga gggacttctc ctccagtgga cctgaaggac       610
Val Val Thr Asn Pro Lys Glu                                               
                145                                                       

gagggatggg atttcatgta accaagagta ttccattttt actaaagcag tgttttcacc      670

tcatatgcta tgttagaagt ccaggcagag acaataaaac attcctgtga aaggcacttt      730

tcattccact ttaacttgat tttttaaatt cccttattgt cccttccaaa aaaaagagaa      790

tcaaaatttt acaaagaatc aaaggaattc tagaaagtat ctgggcagaa cgctaggaga      850

gatccaaatt tccattgtct tgcaagcaaa gcacgtatta aatatgatct gcagccatta      910

aaaagacaca ttctgtaaaa aaaaaaaa                                         938


<210>  692
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  692

Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 
        35                  40                  45              


Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn 
    130                 135                 140                 


Pro Lys Glu 
145         


<210>  693
<211>  2053
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (530)..(1213)

<400>  693
caggcagcag gcagcaggcg ggcgcgctgt ggctccgcgc cgcgcggtcc gggctctgtt       60

cattcatgat tggtactcgg ccctccgaga cccagcccga gcgcagggag gggagccgag      120

tgtgcggcag gaggggcggg cggacggcgg ctcccgcacc gcacgcggcg ctggctcggc      180

agcctcggcc gggcggccgc tctggccccg tgtccagtgc caggcaggct tcagggcacc      240

gtcctcggcc ctgggcgagg gaaccgccgg gccgggtcct cgcgcgggga agcggttccg      300

aaggctcgcg gggagcggct agccctgagt ccctgcatgt gcggggctga agaaggaagc      360

cagaagcctc ctagcctcgc ctccacgctt gctgaatacc aagctgcagg cgagctgccg      420

ggcgcttttc tctcctccaa ttcagagtag acaaaccacg gggatttctt tccagggtag      480

gggaggggcc gggcccgggg tcccaactcg cactcaagtc ttcgctgcc atg ggg gcc      538
                                                      Met Gly Ala         
                                                      1                   

gtc atg ggc acc ttc tca tct ctg caa acc aaa caa agg cga ccc tcg        586
Val Met Gly Thr Phe Ser Ser Leu Gln Thr Lys Gln Arg Arg Pro Ser           
    5                   10                  15                            

aaa gac atc gcc tgg tgg tat tac cag tat cag aga gat aag att gaa        634
Lys Asp Ile Ala Trp Trp Tyr Tyr Gln Tyr Gln Arg Asp Lys Ile Glu           
20                  25                  30                  35            

gat gag ctg gag atg acc atg gtt tgc cat cgg ccc gag gga ctg gag        682
Asp Glu Leu Glu Met Thr Met Val Cys His Arg Pro Glu Gly Leu Glu           
                40                  45                  50                

cag ctc gag gcc cag acc aac ttc acc aag agg gag ctg cag gtc ctt        730
Gln Leu Glu Ala Gln Thr Asn Phe Thr Lys Arg Glu Leu Gln Val Leu           
            55                  60                  65                    

tat cga ggc ttc aaa aat gag tgc ccc agt ggt gtg gtc aac gaa gac        778
Tyr Arg Gly Phe Lys Asn Glu Cys Pro Ser Gly Val Val Asn Glu Asp           
        70                  75                  80                        

aca ttc aag cag atc tat gct cag ttt ttc cct cat gga gat gcc agc        826
Thr Phe Lys Gln Ile Tyr Ala Gln Phe Phe Pro His Gly Asp Ala Ser           
    85                  90                  95                            

acg tat gcc cat tac ctc ttc aat gcc ttc gac acc act cag aca ggc        874
Thr Tyr Ala His Tyr Leu Phe Asn Ala Phe Asp Thr Thr Gln Thr Gly           
100                 105                 110                 115           

tcc gtg aag ttc gag gac ttt gta acc gct ctg tcg att tta ttg aga        922
Ser Val Lys Phe Glu Asp Phe Val Thr Ala Leu Ser Ile Leu Leu Arg           
                120                 125                 130               

gga act gtc cac gag aaa cta agg tgg aca ttt aat ttg tat gac atc        970
Gly Thr Val His Glu Lys Leu Arg Trp Thr Phe Asn Leu Tyr Asp Ile           
            135                 140                 145                   

aac aag gac gga tac ata aac aaa gag gag atg atg gac att gtc aaa       1018
Asn Lys Asp Gly Tyr Ile Asn Lys Glu Glu Met Met Asp Ile Val Lys           
        150                 155                 160                       

gcc atc tat gac atg atg ggg aaa tac aca tat cct gtg ctc aaa gag       1066
Ala Ile Tyr Asp Met Met Gly Lys Tyr Thr Tyr Pro Val Leu Lys Glu           
    165                 170                 175                           

gac act cca agg cag cat gtg gac gtc ttc ttc cag aaa atg gac aaa       1114
Asp Thr Pro Arg Gln His Val Asp Val Phe Phe Gln Lys Met Asp Lys           
180                 185                 190                 195           

aat aaa gat ggc atc gta act tta gat gaa ttt ctt gaa tca tgt cag       1162
Asn Lys Asp Gly Ile Val Thr Leu Asp Glu Phe Leu Glu Ser Cys Gln           
                200                 205                 210               

gag gac gac aac atc atg agg tct ctc cag ctg ttt caa aat gtc atg       1210
Glu Asp Asp Asn Ile Met Arg Ser Leu Gln Leu Phe Gln Asn Val Met           
            215                 220                 225                   

taa ctggtgacac tcagccattc agctctcaga gacattgtac taaacaacca            1263

ccttaacacc ctgatctgcc cttgttctga ttttacacac caactcttgg gacagaaaca     1323

ccttttacac tttggaagaa ttctctgctg aagactttct atggaaccca gcatcatgtg     1383

gctcagtctc tgattgccaa ctcttcctct ttcttcttct tgagagagac aagatgaaat     1443

ttgagtttgt tttggaagca tgctcatctc ctcacactgc tgccctatgg aaggtccctc     1503

tgcttaagct taaacagtag tgcacaaaat atgctgctta cgtgccccca gcccactgcc     1563

tccaagtcag gcagaccttg gtgaatctgg aagcaagagg acctgagcca gatgcacacc     1623

atctctgatg gcctcccaaa ccaatgtgcc tgtttctctt cctttggtgg gaagaatgag     1683

agttatccag aacaattagg atctgtcatg accagattgg gagagccagc acctaacata     1743

tgtgggatag gactgaatta ttaagcatga tattgtctga tgacccaaac tgcccatgtc     1803

atttgtttcc agaaacgagg accaataatt ctctcacact ggcatttgtg ctggtagtac     1863

aagtccttta atatgtccag gaagggagcc attgcccagt ggtccatatc tccaccacat     1923

cccctgcttg agcccagcgc tgcatgtccc tcccaagaag tccagaatgc ctgcaaattg     1983

ctgtaatttt ataccatgtt ctaaccaata aacagaacta tttcttacac tctcaaaaaa     2043

aaaaaaaaaa                                                            2053


<210>  694
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  694

Met Gly Ala Val Met Gly Thr Phe Ser Ser Leu Gln Thr Lys Gln Arg 
1               5                   10                  15      


Arg Pro Ser Lys Asp Ile Ala Trp Trp Tyr Tyr Gln Tyr Gln Arg Asp 
            20                  25                  30          


Lys Ile Glu Asp Glu Leu Glu Met Thr Met Val Cys His Arg Pro Glu 
        35                  40                  45              


Gly Leu Glu Gln Leu Glu Ala Gln Thr Asn Phe Thr Lys Arg Glu Leu 
    50                  55                  60                  


Gln Val Leu Tyr Arg Gly Phe Lys Asn Glu Cys Pro Ser Gly Val Val 
65                  70                  75                  80  


Asn Glu Asp Thr Phe Lys Gln Ile Tyr Ala Gln Phe Phe Pro His Gly 
                85                  90                  95      


Asp Ala Ser Thr Tyr Ala His Tyr Leu Phe Asn Ala Phe Asp Thr Thr 
            100                 105                 110         


Gln Thr Gly Ser Val Lys Phe Glu Asp Phe Val Thr Ala Leu Ser Ile 
        115                 120                 125             


Leu Leu Arg Gly Thr Val His Glu Lys Leu Arg Trp Thr Phe Asn Leu 
    130                 135                 140                 


Tyr Asp Ile Asn Lys Asp Gly Tyr Ile Asn Lys Glu Glu Met Met Asp 
145                 150                 155                 160 


Ile Val Lys Ala Ile Tyr Asp Met Met Gly Lys Tyr Thr Tyr Pro Val 
                165                 170                 175     


Leu Lys Glu Asp Thr Pro Arg Gln His Val Asp Val Phe Phe Gln Lys 
            180                 185                 190         


Met Asp Lys Asn Lys Asp Gly Ile Val Thr Leu Asp Glu Phe Leu Glu 
        195                 200                 205             


Ser Cys Gln Glu Asp Asp Asn Ile Met Arg Ser Leu Gln Leu Phe Gln 
    210                 215                 220                 


Asn Val Met 
225         


<210>  695
<211>  1728
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (282)..(1154)

<400>  695
ggccttgtgg tctcatcgcg cgcaggatcc gggccgggcg ggggcggggg cggggcgcgt       60

ccgcggaggg gggcggttgg cggctcccga gcccagcgcc gcgctcagtc cggaccccgt      120

gaccggcggc cgaggccccg cctccgtcag tctgtccttc gggtcctcag cacagccgtg      180

ccgcccttcc tagggtgtgg agagcgggcc ccgccctgaa ggggcaccgt gggctggggg      240

gcctgttttg gagcaggcac cggtggccga gctccgtgac c atg aag gtc aag gtc      296
                                              Met Lys Val Lys Val         
                                              1               5           

atc ccc gtg ctc gag gac aac tac atg tac ctg gtc atc gag gag ctc        344
Ile Pro Val Leu Glu Asp Asn Tyr Met Tyr Leu Val Ile Glu Glu Leu           
                10                  15                  20                

acg cgc gag gcg gtg gcc gtg gac gtg gct gtg ccc aag agg ctg ctg        392
Thr Arg Glu Ala Val Ala Val Asp Val Ala Val Pro Lys Arg Leu Leu           
            25                  30                  35                    

gag atc gtg ggc cgg gag ggg gtg tct ctg acc gct gtg ctg acc acc        440
Glu Ile Val Gly Arg Glu Gly Val Ser Leu Thr Ala Val Leu Thr Thr           
        40                  45                  50                        

cac cat cac tgg gac cac gcg cgg gga aac ccg gag ctg gcg cgg ctt        488
His His His Trp Asp His Ala Arg Gly Asn Pro Glu Leu Ala Arg Leu           
    55                  60                  65                            

cgt ccc ggg ctg gcg gtg ctg ggc gcg gac gag cgc atc ttc tcg ctg        536
Arg Pro Gly Leu Ala Val Leu Gly Ala Asp Glu Arg Ile Phe Ser Leu           
70                  75                  80                  85            

acg cgc agg ctg gcg cac ggc gag gag ctg cgg ttc ggg gcc atc cac        584
Thr Arg Arg Leu Ala His Gly Glu Glu Leu Arg Phe Gly Ala Ile His           
                90                  95                  100               

gtg cgt tgc ctc ctg acg ccc ggc cac acc gcc ggc cac atg agc tac        632
Val Arg Cys Leu Leu Thr Pro Gly His Thr Ala Gly His Met Ser Tyr           
            105                 110                 115                   

ttc ctg tgg gag gac gat tgc ccg gac cca ccc gcc ctg ttc tcg ggc        680
Phe Leu Trp Glu Asp Asp Cys Pro Asp Pro Pro Ala Leu Phe Ser Gly           
        120                 125                 130                       

gac gcg ctg tcg gtg gcc ggc tgc ggc tcg tgc ctg gag ggc agc gcc        728
Asp Ala Leu Ser Val Ala Gly Cys Gly Ser Cys Leu Glu Gly Ser Ala           
    135                 140                 145                           

cag cag atg tac cag agc ctg gcc gag ctg ggt acc ctg ccc ccc gag        776
Gln Gln Met Tyr Gln Ser Leu Ala Glu Leu Gly Thr Leu Pro Pro Glu           
150                 155                 160                 165           

acg aag gtg ttc tgc ggc cac gag cac acg ctt agc aac ctg gag ttt        824
Thr Lys Val Phe Cys Gly His Glu His Thr Leu Ser Asn Leu Glu Phe           
                170                 175                 180               

gcc cag aaa gtg gag ccc tgc aac gac cac gtg aga gcc aag ctg tcc        872
Ala Gln Lys Val Glu Pro Cys Asn Asp His Val Arg Ala Lys Leu Ser           
            185                 190                 195                   

tgg gct aag gca cgg ccc ctt tcc cgc cgc ggc aag agg gtg ggg ggg        920
Trp Ala Lys Ala Arg Pro Leu Ser Arg Arg Gly Lys Arg Val Gly Gly           
        200                 205                 210                       

gag gga aca ggc ttc ggg gtg ggg ggg gct ctc aga caa ggc cta atg        968
Glu Gly Thr Gly Phe Gly Val Gly Gly Ala Leu Arg Gln Gly Leu Met           
    215                 220                 225                           

gtg acc ggg gcc tgt ggt cac tcc aga aga ggg atg agg atg acg tgc       1016
Val Thr Gly Ala Cys Gly His Ser Arg Arg Gly Met Arg Met Thr Cys           
230                 235                 240                 245           

cca ctg tgc cgt cga ctc tgg gcg agg agc gcc tct aca acc cct tcc       1064
Pro Leu Cys Arg Arg Leu Trp Ala Arg Ser Ala Ser Thr Thr Pro Ser           
                250                 255                 260               

tgc ggg tgg cgt gag tat ggc tgt tgt ccc ggg gcc tcc acc gtt acg       1112
Cys Gly Trp Arg Glu Tyr Gly Cys Cys Pro Gly Ala Ser Thr Val Thr           
            265                 270                 275                   

tgg acc ctt agg aag gca tct ggg gac tgc gtg ttg ggc tga               1154
Trp Thr Leu Arg Lys Ala Ser Gly Asp Cys Val Leu Gly                       
        280                 285                 290                       

gtgagcatct ctggcttggg ggaggctgct cattaagtgc ctgcctgccc gcccacccct     1214

cggcgccatg ctcccgcgtg ggcagcgggc cctgcgcctc actgcacccc tccctgcaga     1274

gaggagccgg tgcgcaagtt cacgggcaag gcggtccccg ccgacgtcct ggaggcgcta     1334

tgcaaggagc gggcgcgctt cgaacaggcg ggcgagccgc ggcagccaca ggcgcgggcc     1394

ctccttgcgc tgcagtgggg gctcctgagt gcagccccac acgactgagc cacccagacc     1454

ctcacagggc tggggcctgc gtccctcctc gtgacctcgg ccagctggac ccacatgagg     1514

gccacctctg gaaccttctt cgaggccctg gccagccatc tgcccagcct cggagggtgg     1574

gcaacctggt gcttcccggg tggacacaca ggaccactca gtggggcctg tgtgggcgcc     1634

gagacctggg tgtctgggaa gtggggcaca cggggcctcc gaactatgaa taaagctttg     1694

aaaggccaaa aaaaaaaaaa aaaaaaaaaa aaaa                                 1728


<210>  696
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  696

Met Lys Val Lys Val Ile Pro Val Leu Glu Asp Asn Tyr Met Tyr Leu 
1               5                   10                  15      


Val Ile Glu Glu Leu Thr Arg Glu Ala Val Ala Val Asp Val Ala Val 
            20                  25                  30          


Pro Lys Arg Leu Leu Glu Ile Val Gly Arg Glu Gly Val Ser Leu Thr 
        35                  40                  45              


Ala Val Leu Thr Thr His His His Trp Asp His Ala Arg Gly Asn Pro 
    50                  55                  60                  


Glu Leu Ala Arg Leu Arg Pro Gly Leu Ala Val Leu Gly Ala Asp Glu 
65                  70                  75                  80  


Arg Ile Phe Ser Leu Thr Arg Arg Leu Ala His Gly Glu Glu Leu Arg 
                85                  90                  95      


Phe Gly Ala Ile His Val Arg Cys Leu Leu Thr Pro Gly His Thr Ala 
            100                 105                 110         


Gly His Met Ser Tyr Phe Leu Trp Glu Asp Asp Cys Pro Asp Pro Pro 
        115                 120                 125             


Ala Leu Phe Ser Gly Asp Ala Leu Ser Val Ala Gly Cys Gly Ser Cys 
    130                 135                 140                 


Leu Glu Gly Ser Ala Gln Gln Met Tyr Gln Ser Leu Ala Glu Leu Gly 
145                 150                 155                 160 


Thr Leu Pro Pro Glu Thr Lys Val Phe Cys Gly His Glu His Thr Leu 
                165                 170                 175     


Ser Asn Leu Glu Phe Ala Gln Lys Val Glu Pro Cys Asn Asp His Val 
            180                 185                 190         


Arg Ala Lys Leu Ser Trp Ala Lys Ala Arg Pro Leu Ser Arg Arg Gly 
        195                 200                 205             


Lys Arg Val Gly Gly Glu Gly Thr Gly Phe Gly Val Gly Gly Ala Leu 
    210                 215                 220                 


Arg Gln Gly Leu Met Val Thr Gly Ala Cys Gly His Ser Arg Arg Gly 
225                 230                 235                 240 


Met Arg Met Thr Cys Pro Leu Cys Arg Arg Leu Trp Ala Arg Ser Ala 
                245                 250                 255     


Ser Thr Thr Pro Ser Cys Gly Trp Arg Glu Tyr Gly Cys Cys Pro Gly 
            260                 265                 270         


Ala Ser Thr Val Thr Trp Thr Leu Arg Lys Ala Ser Gly Asp Cys Val 
        275                 280                 285             


Leu Gly 
    290 


<210>  697
<211>  1941
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (105)..(1223)

<400>  697
gagagggcga aggtaggctg gcagatacgt tcgtcagctt gctcctttct gcccgtggac       60

gccgccgaag aagcatcgtt aaagtctctc ttcaccctgc cgtc atg tct aag tca       116
                                                 Met Ser Lys Ser          
                                                 1                        

gag tct cct aaa gag ccc gaa cag ctg agg aag ctc ttc att gga ggg        164
Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu Phe Ile Gly Gly           
5                   10                  15                  20            

ttg agc ttt gaa aca act gat gag agc ctg agg agc cat ttt gag caa        212
Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser His Phe Glu Gln           
                25                  30                  35                

tgg gga acg ctc acg gac tgt gtg gta atg aga gat cca aac acc aag        260
Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp Pro Asn Thr Lys           
            40                  45                  50                    

cgc tcc agg ggc ttt ggg ttt gtc aca tat gcc act gtg gag gag gtg        308
Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr Val Glu Glu Val           
        55                  60                  65                        

gat gca gct atg aat gca agg cca cac aag gtg gat gga aga gtt gtg        356
Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp Gly Arg Val Val           
    70                  75                  80                            

gaa cca aag aga gct gtc tcc aga gaa gat tct caa aga cca ggt gcc        404
Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln Arg Pro Gly Ala           
85                  90                  95                  100           

cac tta act gtg aaa aag ata ttt gtt ggt ggc att aaa gaa gac act        452
His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys Glu Asp Thr           
                105                 110                 115               

gaa gaa cat cac cta aga gat tat ttt gaa cag tat gga aaa att gaa        500
Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr Gly Lys Ile Glu           
            120                 125                 130                   

gtg att gaa atc atg act gac cga ggc agt ggc aag aaa agg ggc ttt        548
Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys Lys Arg Gly Phe           
        135                 140                 145                       

gcc ttt gta acc ttt gac gac cat gac tcc gtg gat aag att gtc att        596
Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp Lys Ile Val Ile           
    150                 155                 160                           

cag aaa tac cat act gtg aat ggc cac aac tgt gaa gtt aga aaa gcc        644
Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu Val Arg Lys Ala           
165                 170                 175                 180           

ctg tca aag caa gag atg gct agt gct tca tcc agc caa aga ggt cga        692
Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser Gln Arg Gly Arg           
                185                 190                 195               

agt ggt tct gga aac ttt ggt ggt ggt cgt gga ggt ggt ttc ggt ggg        740
Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly Phe Gly Gly           
            200                 205                 210                   

aat gac aac ttc ggt cgt gga gga aac ttc agt ggt cgt ggt ggc ttt        788
Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly Arg Gly Gly Phe           
        215                 220                 225                       

ggt ggc agc cgt ggt ggt ggt gga tat ggt ggc agt ggg gat ggc tat        836
Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Tyr           
    230                 235                 240                           

aat gga ttt ggt aat gat ggt ggt tat gga gga ggc ggc cct ggt tac        884
Asn Gly Phe Gly Asn Asp Gly Gly Tyr Gly Gly Gly Gly Pro Gly Tyr           
245                 250                 255                 260           

tct gga gga agc aga ggc tat gga agt ggt gga cag ggt tat gga aac        932
Ser Gly Gly Ser Arg Gly Tyr Gly Ser Gly Gly Gln Gly Tyr Gly Asn           
                265                 270                 275               

cag ggc agt ggc tat ggc ggg agt ggc agc tat gac agc tat aac aac        980
Gln Gly Ser Gly Tyr Gly Gly Ser Gly Ser Tyr Asp Ser Tyr Asn Asn           
            280                 285                 290                   

gga ggc gga ggc ggc ttt ggc ggt ggt agt gga agc aat ttt gga ggt       1028
Gly Gly Gly Gly Gly Phe Gly Gly Gly Ser Gly Ser Asn Phe Gly Gly           
        295                 300                 305                       

ggt gga agc tac aat gat ttt ggg aat tac aac aat cag tct tca aat       1076
Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn           
    310                 315                 320                           

ttt gga ccc atg aag gga gga aat ttt gga ggc aga agc tct ggc ccc       1124
Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro           
325                 330                 335                 340           

tat ggc ggt gga ggc caa tac ttt gca aaa cca cga aac caa ggt ggc       1172
Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly           
                345                 350                 355               

tat ggc ggt tcc agc agc agc agt agc tat ggc agt ggc aga aga ttt       1220
Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe           
            360                 365                 370                   

taa ttaggaaaca aagcttagca ggagaggaga gccagagaag tgacagggaa            1273

gctacaggtt acaacagatt tgtgaactca gccaagcaca gtggtggcag ggcctagctg     1333

ctacaaagaa gacatgtttt agacaaatac tcatgtgtat gggcaaaaaa ctcgaggact     1393

gtatttgtga ctaattgtat aacaggttat tttagtttct gttctgtgga aagtgtaaag     1453

cattccaaca aagggtttta atgtagattt ttttttttgc accccatgct gttgattgct     1513

aaatgtaaca gtctgatcgt gacgctgaat aaatgtcttt tttttaatgt gctgtgtaaa     1573

gttagtctac tcttaagcca tcttggtaaa tttccccaac agtgtgaagt tagaattcct     1633

tcagggtgat gccaggttct atttggaatt tatatacaac ctgcttgggt ggagaagcca     1693

ttgtcttcgg aaaccttggt gtagttgaac tgatagttac tgttgtgacc tgaagttcac     1753

cattaaaagg gattacccaa gcaaaatcat ggaatggtta taaaagtgat tgttggcaca     1813

tcctatgcaa tatatctaaa ttgaataatg gtaccagata aaattataga tgggaatgaa     1873

gcttgtgtat ccattatcat gtgtaatcaa taaacgattt aattctcttg aaaaaaaaaa     1933

aaaaaaaa                                                              1941


<210>  698
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  698

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Gly Tyr Gly Gly Gly 
                245                 250                 255     


Gly Pro Gly Tyr Ser Gly Gly Ser Arg Gly Tyr Gly Ser Gly Gly Gln 
            260                 265                 270         


Gly Tyr Gly Asn Gln Gly Ser Gly Tyr Gly Gly Ser Gly Ser Tyr Asp 
        275                 280                 285             


Ser Tyr Asn Asn Gly Gly Gly Gly Gly Phe Gly Gly Gly Ser Gly Ser 
    290                 295                 300                 


Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn 
305                 310                 315                 320 


Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg 
                325                 330                 335     


Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg 
            340                 345                 350         


Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser 
        355                 360                 365             


Gly Arg Arg Phe 
    370         


<210>  699
<211>  12057
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (320)..(10510)

<400>  699
acagtgatat aatgatgatg ggtgtcacaa cccgcatttg aacttgcagg cgagctgccc       60

cgagcctttc tggggaagaa ctccaggcgt gcggacgcaa cagccgagaa cattaggtgt      120

tgtggacagg agctgggacc aagatcttcg gccagccccg catcctcccg catcttccag      180

caccgtcccg caccctccgc atccttcccc gggccaccac gcttcctatg tgacccgcct      240

gggcaacgcc gaacccagtc gcgcagcgct gcagtgaatt ttccccccaa actgcaataa      300

gccgccttcc aaggccaag atg ttc ata aat ata aag agc atc tta tgg atg       352
                     Met Phe Ile Asn Ile Lys Ser Ile Leu Trp Met          
                     1               5                   10               

tgt tca acc tta ata gta acc cat gcg cta cat aaa gtc aaa gtg gga        400
Cys Ser Thr Leu Ile Val Thr His Ala Leu His Lys Val Lys Val Gly           
            15                  20                  25                    

aaa agc cca ccg gtg agg ggc tcc ctc tct gga aaa gtc agc cta cct        448
Lys Ser Pro Pro Val Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro           
        30                  35                  40                        

tgt cat ttt tca acg atg cct act ttg cca ccc agt tac aac acc agt        496
Cys His Phe Ser Thr Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser           
    45                  50                  55                            

gaa ttt ctc cgc atc aaa tgg tct aag att gaa gtg gac aaa aat gga        544
Glu Phe Leu Arg Ile Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly           
60                  65                  70                  75            

aaa gat ttg aaa gag act act gtc ctt gtg gcc caa aat gga aat atc        592
Lys Asp Leu Lys Glu Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile           
                80                  85                  90                

aag att ggt cag gac tac aaa ggg aga gtg tct gtg ccc aca cat ccc        640
Lys Ile Gly Gln Asp Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro           
            95                  100                 105                   

gag gct gtg ggc gat gcc tcc ctc act gtg gtc aag ctg ctg gca agt        688
Glu Ala Val Gly Asp Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser           
        110                 115                 120                       

gat gcg ggt ctt tac cgc tgt gac gtc atg tac ggg att gaa gac aca        736
Asp Ala Gly Leu Tyr Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr           
    125                 130                 135                           

caa gac acg gtg tca ctg act gtg gat ggg gtt gtg ttt cac tac agg        784
Gln Asp Thr Val Ser Leu Thr Val Asp Gly Val Val Phe His Tyr Arg           
140                 145                 150                 155           

gcg gca acc agc agg tac aca ctg aat ttt gag gct gct cag aag gct        832
Ala Ala Thr Ser Arg Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala           
                160                 165                 170               

tgt ttg gac gtt ggg gca gtc ata gca act cca gag cag ctc ttt gct        880
Cys Leu Asp Val Gly Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala           
            175                 180                 185                   

gcc tat gaa gat gga ttt gag cag tgt gac gca ggc tgg ctg gct gat        928
Ala Tyr Glu Asp Gly Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp           
        190                 195                 200                       

cag act gtc aga tat ccc atc cgg gct ccc aga gta ggc tgt tat gga        976
Gln Thr Val Arg Tyr Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly           
    205                 210                 215                           

gat aag atg gga aag gca gga gtc agg act tat gga ttc cgt tct ccc       1024
Asp Lys Met Gly Lys Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro           
220                 225                 230                 235           

cag gaa act tac gat gtg tat tgt tat gtg gat cat ctg gat ggt gat       1072
Gln Glu Thr Tyr Asp Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp           
                240                 245                 250               

gtg ttc cac ctc act gtc ccc agt aaa ttc acc ttc gag gag gct gca       1120
Val Phe His Leu Thr Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala           
            255                 260                 265                   

aaa gag tgt gaa aac cag gat gcc agg ctg gca aca gtg ggg gaa ctc       1168
Lys Glu Cys Glu Asn Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu           
        270                 275                 280                       

cag gcg gca tgg agg aac ggc ttt gac cag tgc gat tac ggg tgg ctg       1216
Gln Ala Ala Trp Arg Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu           
    285                 290                 295                           

tcg gat gcc agc gtg cgc cac cct gtg act gtg gcc agg gcc cag tgt       1264
Ser Asp Ala Ser Val Arg His Pro Val Thr Val Ala Arg Ala Gln Cys           
300                 305                 310                 315           

gga ggt ggt cta ctt ggg gtg aga acc ctg tat cgt ttt gag aac cag       1312
Gly Gly Gly Leu Leu Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln           
                320                 325                 330               

aca ggc ttc cct ccc cct gat agc aga ttt gat gcc tac tgc ttt aaa       1360
Thr Gly Phe Pro Pro Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys           
            335                 340                 345                   

cct aaa gag gct aca acc atc gat ttg agt atc ctc gca gaa act gca       1408
Pro Lys Glu Ala Thr Thr Ile Asp Leu Ser Ile Leu Ala Glu Thr Ala           
        350                 355                 360                       

tca ccc agt tta tcc aaa gaa cca caa atg gtt tct gat aga act aca       1456
Ser Pro Ser Leu Ser Lys Glu Pro Gln Met Val Ser Asp Arg Thr Thr           
    365                 370                 375                           

cca atc atc cct tta gtt gat gaa tta cct gtc att cca aca gag ttc       1504
Pro Ile Ile Pro Leu Val Asp Glu Leu Pro Val Ile Pro Thr Glu Phe           
380                 385                 390                 395           

cct ccc gtg gga aat att gtc agt ttt gaa cag aaa gcc aca gtc caa       1552
Pro Pro Val Gly Asn Ile Val Ser Phe Glu Gln Lys Ala Thr Val Gln           
                400                 405                 410               

cct cag gct atc aca gat agt tta gcc acc aaa tta ccc aca cct act       1600
Pro Gln Ala Ile Thr Asp Ser Leu Ala Thr Lys Leu Pro Thr Pro Thr           
            415                 420                 425                   

ggc agt acc aag aag ccc tgg gat atg gat gac tac tca cct tct gct       1648
Gly Ser Thr Lys Lys Pro Trp Asp Met Asp Asp Tyr Ser Pro Ser Ala           
        430                 435                 440                       

tca gga cct ctt gga aag cta gac ata tca gaa att aag gaa gaa gtg       1696
Ser Gly Pro Leu Gly Lys Leu Asp Ile Ser Glu Ile Lys Glu Glu Val           
    445                 450                 455                           

ctc cag agt aca act ggc gtc tct cat tat gct acg gat tca tgg gat       1744
Leu Gln Ser Thr Thr Gly Val Ser His Tyr Ala Thr Asp Ser Trp Asp           
460                 465                 470                 475           

ggt gtc gtg gaa gat aaa caa aca caa gaa tcg gtt aca cag att gaa       1792
Gly Val Val Glu Asp Lys Gln Thr Gln Glu Ser Val Thr Gln Ile Glu           
                480                 485                 490               

caa ata gaa gtg ggt cct ttg gta aca tct atg gaa atc tta aag cac       1840
Gln Ile Glu Val Gly Pro Leu Val Thr Ser Met Glu Ile Leu Lys His           
            495                 500                 505                   

att cct tcc aag gaa ttc cct gta act gaa aca cca ttg gta act gca       1888
Ile Pro Ser Lys Glu Phe Pro Val Thr Glu Thr Pro Leu Val Thr Ala           
        510                 515                 520                       

aga atg atc ctg gaa tcc aaa act gaa aag aaa atg gta agc act gtt       1936
Arg Met Ile Leu Glu Ser Lys Thr Glu Lys Lys Met Val Ser Thr Val           
    525                 530                 535                           

tct gaa ttg gta acc aca ggt cac tat gga ttc acc ttg gga gaa gag       1984
Ser Glu Leu Val Thr Thr Gly His Tyr Gly Phe Thr Leu Gly Glu Glu           
540                 545                 550                 555           

gat gat gaa gac aga aca ctt aca gtt gga tct gat gag agc acc ttg       2032
Asp Asp Glu Asp Arg Thr Leu Thr Val Gly Ser Asp Glu Ser Thr Leu           
                560                 565                 570               

atc ttt gac caa att cct gaa gtc att acg gtg tca aag act tca gaa       2080
Ile Phe Asp Gln Ile Pro Glu Val Ile Thr Val Ser Lys Thr Ser Glu           
            575                 580                 585                   

gac acc atc cac act cat tta gaa gac ttg gag tca gtc tca gca tcc       2128
Asp Thr Ile His Thr His Leu Glu Asp Leu Glu Ser Val Ser Ala Ser           
        590                 595                 600                       

aca act gtt tcc cct tta att atg cct gat aat aat gga tca tcc atg       2176
Thr Thr Val Ser Pro Leu Ile Met Pro Asp Asn Asn Gly Ser Ser Met           
    605                 610                 615                           

gat gac tgg gaa gag aga caa act agt ggt agg ata acg gaa gag ttt       2224
Asp Asp Trp Glu Glu Arg Gln Thr Ser Gly Arg Ile Thr Glu Glu Phe           
620                 625                 630                 635           

ctt ggc aaa tat ctg tct act aca cct ttt cca tca cag cat cgt aca       2272
Leu Gly Lys Tyr Leu Ser Thr Thr Pro Phe Pro Ser Gln His Arg Thr           
                640                 645                 650               

gaa ata gaa ttg ttt cct tat tct ggt gat aaa ata tta gta gag gga       2320
Glu Ile Glu Leu Phe Pro Tyr Ser Gly Asp Lys Ile Leu Val Glu Gly           
            655                 660                 665                   

att tcc aca gtt att tat cct tct cta caa aca gaa atg aca cat aga       2368
Ile Ser Thr Val Ile Tyr Pro Ser Leu Gln Thr Glu Met Thr His Arg           
        670                 675                 680                       

aga gaa aga aca gaa aca cta ata cca gag atg aga aca gat act tat       2416
Arg Glu Arg Thr Glu Thr Leu Ile Pro Glu Met Arg Thr Asp Thr Tyr           
    685                 690                 695                           

aca gat gaa ata caa gaa gag atc act aaa agt cca ttt atg gga aaa       2464
Thr Asp Glu Ile Gln Glu Glu Ile Thr Lys Ser Pro Phe Met Gly Lys           
700                 705                 710                 715           

aca gaa gaa gaa gtc ttc tct ggg atg aaa ctc tct aca tct ctc tca       2512
Thr Glu Glu Glu Val Phe Ser Gly Met Lys Leu Ser Thr Ser Leu Ser           
                720                 725                 730               

gag cca att cat gtt aca gag tct tct gtg gaa atg acc aag tct ttt       2560
Glu Pro Ile His Val Thr Glu Ser Ser Val Glu Met Thr Lys Ser Phe           
            735                 740                 745                   

gat ttc cca aca ttg ata aca aag tta agt gca gag cca aca gaa gta       2608
Asp Phe Pro Thr Leu Ile Thr Lys Leu Ser Ala Glu Pro Thr Glu Val           
        750                 755                 760                       

aga gat atg gag gaa gac ttt aca gca act cca ggt act aca aaa tat       2656
Arg Asp Met Glu Glu Asp Phe Thr Ala Thr Pro Gly Thr Thr Lys Tyr           
    765                 770                 775                           

gat gaa aat att aca aca gtg ctt ttg gcc cat ggt act tta agt gtt       2704
Asp Glu Asn Ile Thr Thr Val Leu Leu Ala His Gly Thr Leu Ser Val           
780                 785                 790                 795           

gaa gca gcc act gta tca aaa tgg tca tgg gat gaa gat aat aca aca       2752
Glu Ala Ala Thr Val Ser Lys Trp Ser Trp Asp Glu Asp Asn Thr Thr           
                800                 805                 810               

tcc aag cct tta gag tct aca gaa cct tca gcc tct tca aaa ttg ccc       2800
Ser Lys Pro Leu Glu Ser Thr Glu Pro Ser Ala Ser Ser Lys Leu Pro           
            815                 820                 825                   

cct gcc tta ctc aca act gtg ggg atg aat gga aag gat aaa gac atc       2848
Pro Ala Leu Leu Thr Thr Val Gly Met Asn Gly Lys Asp Lys Asp Ile           
        830                 835                 840                       

cca agt ttc act gaa gat gga gca gat gaa ttt act ctt att cca gat       2896
Pro Ser Phe Thr Glu Asp Gly Ala Asp Glu Phe Thr Leu Ile Pro Asp           
    845                 850                 855                           

agt act caa aag cag tta gag gag gtt act gat gaa gac ata gca gcc       2944
Ser Thr Gln Lys Gln Leu Glu Glu Val Thr Asp Glu Asp Ile Ala Ala           
860                 865                 870                 875           

cat gga aaa ttc aca att aga ttt cag cca act aca tca act ggt att       2992
His Gly Lys Phe Thr Ile Arg Phe Gln Pro Thr Thr Ser Thr Gly Ile           
                880                 885                 890               

gca gaa aag tca act ttg aga gat tct aca act gaa gaa aaa gtt cca       3040
Ala Glu Lys Ser Thr Leu Arg Asp Ser Thr Thr Glu Glu Lys Val Pro           
            895                 900                 905                   

cct atc aca agc act gaa ggc caa gtt tat gca acc atg gaa gga agt       3088
Pro Ile Thr Ser Thr Glu Gly Gln Val Tyr Ala Thr Met Glu Gly Ser           
        910                 915                 920                       

gct ttg ggt gaa gta gaa gat gtg gac ctc tct aag cca gta tct act       3136
Ala Leu Gly Glu Val Glu Asp Val Asp Leu Ser Lys Pro Val Ser Thr           
    925                 930                 935                           

gtt ccc caa ttt gca cac act tca gag gtg gaa gga tta gca ttt gtt       3184
Val Pro Gln Phe Ala His Thr Ser Glu Val Glu Gly Leu Ala Phe Val           
940                 945                 950                 955           

agt tat agt agc acc caa gag cct act act tat gta gac tct tcc cat       3232
Ser Tyr Ser Ser Thr Gln Glu Pro Thr Thr Tyr Val Asp Ser Ser His           
                960                 965                 970               

acc att cct ctt tct gta att ccc aag aca gac tgg gga gtg tta gta       3280
Thr Ile Pro Leu Ser Val Ile Pro Lys Thr Asp Trp Gly Val Leu Val           
            975                 980                 985                   

cct tct gtt cca tca gaa gat gaa gtt cta ggt gaa ccc  tct caa gac      3328
Pro Ser Val Pro Ser Glu Asp Glu Val Leu Gly Glu Pro  Ser Gln Asp          
        990                 995                 1000                      

ata ctt  gtc att gat cag act  cgc ctt gaa gcg act  att tct cca        3373
Ile Leu  Val Ile Asp Gln Thr  Arg Leu Glu Ala Thr  Ile Ser Pro            
    1005                 1010                 1015                        

gaa act  atg aga aca aca aaa  atc aca gag gga aca  act cag gaa        3418
Glu Thr  Met Arg Thr Thr Lys  Ile Thr Glu Gly Thr  Thr Gln Glu            
    1020                 1025                 1030                        

gaa ttc  cct tgg aaa gaa cag  act gca gag aaa cca  gtt cct gct        3463
Glu Phe  Pro Trp Lys Glu Gln  Thr Ala Glu Lys Pro  Val Pro Ala            
    1035                 1040                 1045                        

ctc agt  tct aca gct tgg act  ccc aag gag gca gta  aca cca ctg        3508
Leu Ser  Ser Thr Ala Trp Thr  Pro Lys Glu Ala Val  Thr Pro Leu            
    1050                 1055                 1060                        

gat gaa  caa gag ggc gat gga  tca gca tat aca gtc  tct gaa gat        3553
Asp Glu  Gln Glu Gly Asp Gly  Ser Ala Tyr Thr Val  Ser Glu Asp            
    1065                 1070                 1075                        

gaa ttg  ttg aca ggt tct gag  agg gtc cca gtt tta  gaa aca act        3598
Glu Leu  Leu Thr Gly Ser Glu  Arg Val Pro Val Leu  Glu Thr Thr            
    1080                 1085                 1090                        

cca gtt  gga aaa att gat cac  agt gtg tct tat cca  cca ggt gct        3643
Pro Val  Gly Lys Ile Asp His  Ser Val Ser Tyr Pro  Pro Gly Ala            
    1095                 1100                 1105                        

gta act  gag cac aaa gtg aaa  aca gat gaa gtg gta  aca cta aca        3688
Val Thr  Glu His Lys Val Lys  Thr Asp Glu Val Val  Thr Leu Thr            
    1110                 1115                 1120                        

cca cgc  att ggg cca aaa gta  tct tta agt cca ggg  cct gaa caa        3733
Pro Arg  Ile Gly Pro Lys Val  Ser Leu Ser Pro Gly  Pro Glu Gln            
    1125                 1130                 1135                        

aaa tat  gaa aca gaa ggt agt  agt aca aca gga ttt  aca tca tct        3778
Lys Tyr  Glu Thr Glu Gly Ser  Ser Thr Thr Gly Phe  Thr Ser Ser            
    1140                 1145                 1150                        

ttg agt  cct ttt agt acc cac  att acc cag ctt atg  gaa gaa acc        3823
Leu Ser  Pro Phe Ser Thr His  Ile Thr Gln Leu Met  Glu Glu Thr            
    1155                 1160                 1165                        

act act  gag aaa aca tcc cta  gag gat att gat tta  ggc tca gga        3868
Thr Thr  Glu Lys Thr Ser Leu  Glu Asp Ile Asp Leu  Gly Ser Gly            
    1170                 1175                 1180                        

tta ttt  gaa aag ccc aaa gcc  aca gaa ctc ata gaa  ttt tca aca        3913
Leu Phe  Glu Lys Pro Lys Ala  Thr Glu Leu Ile Glu  Phe Ser Thr            
    1185                 1190                 1195                        

atc aaa  gtc aca gtt cca agt  gat att acc act gcc  ttc agt tca        3958
Ile Lys  Val Thr Val Pro Ser  Asp Ile Thr Thr Ala  Phe Ser Ser            
    1200                 1205                 1210                        

gta gac  aga ctt cac aca act  tca gca ttc aag cca  tct tcc gcg        4003
Val Asp  Arg Leu His Thr Thr  Ser Ala Phe Lys Pro  Ser Ser Ala            
    1215                 1220                 1225                        

atc act  aag aaa cca cct ctc  atc gac agg gaa cct  ggt gaa gaa        4048
Ile Thr  Lys Lys Pro Pro Leu  Ile Asp Arg Glu Pro  Gly Glu Glu            
    1230                 1235                 1240                        

aca acc  agt gac atg gta atc  att gga gaa tca aca  tct cat gtt        4093
Thr Thr  Ser Asp Met Val Ile  Ile Gly Glu Ser Thr  Ser His Val            
    1245                 1250                 1255                        

cct ccc  act acc ctt gaa gat  att gta gcc aag gaa  aca gaa acc        4138
Pro Pro  Thr Thr Leu Glu Asp  Ile Val Ala Lys Glu  Thr Glu Thr            
    1260                 1265                 1270                        

gat att  gat aga gag tat ttc  acg act tca agt cct  cct gct aca        4183
Asp Ile  Asp Arg Glu Tyr Phe  Thr Thr Ser Ser Pro  Pro Ala Thr            
    1275                 1280                 1285                        

cag cca  aca aga cca ccc act  gtg gaa gac aaa gag  gcc ttt gga        4228
Gln Pro  Thr Arg Pro Pro Thr  Val Glu Asp Lys Glu  Ala Phe Gly            
    1290                 1295                 1300                        

cct cag  gcg ctt tct acg cca  cag ccc cca gca agc  aca aaa ttt        4273
Pro Gln  Ala Leu Ser Thr Pro  Gln Pro Pro Ala Ser  Thr Lys Phe            
    1305                 1310                 1315                        

cac cct  gac att aat gtt tat  att att gag gtc aga  gaa aat aag        4318
His Pro  Asp Ile Asn Val Tyr  Ile Ile Glu Val Arg  Glu Asn Lys            
    1320                 1325                 1330                        

aca ggt  cga atg agt gat ttg  agt gta att ggt cat  cca ata gat        4363
Thr Gly  Arg Met Ser Asp Leu  Ser Val Ile Gly His  Pro Ile Asp            
    1335                 1340                 1345                        

tca gaa  tct aaa gaa gat gaa  cct tgt agt gaa gaa  aca gat cca        4408
Ser Glu  Ser Lys Glu Asp Glu  Pro Cys Ser Glu Glu  Thr Asp Pro            
    1350                 1355                 1360                        

gtg cat  gat cta atg gct gaa  att tta cct gaa ttc  cct gac ata        4453
Val His  Asp Leu Met Ala Glu  Ile Leu Pro Glu Phe  Pro Asp Ile            
    1365                 1370                 1375                        

att gaa  ata gac cta tac cac  agt gaa gaa aat gaa  gaa gaa gaa        4498
Ile Glu  Ile Asp Leu Tyr His  Ser Glu Glu Asn Glu  Glu Glu Glu            
    1380                 1385                 1390                        

gaa gag  tgt gca aat gct act  gat gtg aca acc acc  cca tct gtg        4543
Glu Glu  Cys Ala Asn Ala Thr  Asp Val Thr Thr Thr  Pro Ser Val            
    1395                 1400                 1405                        

cag tac  ata aat ggg aag cat  ctc gtt acc act gtg  ccc aag gac        4588
Gln Tyr  Ile Asn Gly Lys His  Leu Val Thr Thr Val  Pro Lys Asp            
    1410                 1415                 1420                        

cca gaa  gct gca gaa gct agg  cgt ggc cag ttt gaa  agt gtt gca        4633
Pro Glu  Ala Ala Glu Ala Arg  Arg Gly Gln Phe Glu  Ser Val Ala            
    1425                 1430                 1435                        

cct tct  cag aat ttc tcg gac  agc tct gaa agt gat  act cat cca        4678
Pro Ser  Gln Asn Phe Ser Asp  Ser Ser Glu Ser Asp  Thr His Pro            
    1440                 1445                 1450                        

ttt gta  ata gcc aaa acg gaa  ttg tct act gct gtg  caa cct aat        4723
Phe Val  Ile Ala Lys Thr Glu  Leu Ser Thr Ala Val  Gln Pro Asn            
    1455                 1460                 1465                        

gaa tct  aca gaa aca act gag  tct ctt gaa gtt aca  tgg aag cct        4768
Glu Ser  Thr Glu Thr Thr Glu  Ser Leu Glu Val Thr  Trp Lys Pro            
    1470                 1475                 1480                        

gag act  tac cct gaa aca tca  gaa cat ttt tca ggt  ggt gag cct        4813
Glu Thr  Tyr Pro Glu Thr Ser  Glu His Phe Ser Gly  Gly Glu Pro            
    1485                 1490                 1495                        

gat gtt  ttc ccc aca gtc cca  ttc cat gag gaa ttt  gaa agt gga        4858
Asp Val  Phe Pro Thr Val Pro  Phe His Glu Glu Phe  Glu Ser Gly            
    1500                 1505                 1510                        

aca gcc  aaa aaa ggg gca gaa  tca gtc aca gag aga  gat act gaa        4903
Thr Ala  Lys Lys Gly Ala Glu  Ser Val Thr Glu Arg  Asp Thr Glu            
    1515                 1520                 1525                        

gtt ggt  cat cag gca cat gaa  cat act gaa cct gta  tct ctg ttt        4948
Val Gly  His Gln Ala His Glu  His Thr Glu Pro Val  Ser Leu Phe            
    1530                 1535                 1540                        

cct gaa  gag tct tca gga gag  att gcc att gac caa  gaa tct cag        4993
Pro Glu  Glu Ser Ser Gly Glu  Ile Ala Ile Asp Gln  Glu Ser Gln            
    1545                 1550                 1555                        

aaa ata  gcc ttt gca agg gct  aca gaa gta aca ttt  ggt gaa gag        5038
Lys Ile  Ala Phe Ala Arg Ala  Thr Glu Val Thr Phe  Gly Glu Glu            
    1560                 1565                 1570                        

gta gaa  aaa agt act tct gtc  aca tac act ccc act  ata gtt cca        5083
Val Glu  Lys Ser Thr Ser Val  Thr Tyr Thr Pro Thr  Ile Val Pro            
    1575                 1580                 1585                        

agt tct  gca tca gca tat gtt  tca gag gaa gaa gca  gtt acc cta        5128
Ser Ser  Ala Ser Ala Tyr Val  Ser Glu Glu Glu Ala  Val Thr Leu            
    1590                 1595                 1600                        

ata gga  aat cct tgg cca gat  gac ctg ttg tct acc  aaa gaa agc        5173
Ile Gly  Asn Pro Trp Pro Asp  Asp Leu Leu Ser Thr  Lys Glu Ser            
    1605                 1610                 1615                        

tgg gta  gaa gca act cct aga  caa gtt gta gag ctc  tca ggg agt        5218
Trp Val  Glu Ala Thr Pro Arg  Gln Val Val Glu Leu  Ser Gly Ser            
    1620                 1625                 1630                        

tct tcg  att cca att aca gaa  ggc tct gga gaa gca  gaa gaa gat        5263
Ser Ser  Ile Pro Ile Thr Glu  Gly Ser Gly Glu Ala  Glu Glu Asp            
    1635                 1640                 1645                        

gaa gat  aca atg ttc acc atg  gta act gat tta tca  cag aga aat        5308
Glu Asp  Thr Met Phe Thr Met  Val Thr Asp Leu Ser  Gln Arg Asn            
    1650                 1655                 1660                        

act act  gat aca ctc att act  tta gac act agc agg  ata atc aca        5353
Thr Thr  Asp Thr Leu Ile Thr  Leu Asp Thr Ser Arg  Ile Ile Thr            
    1665                 1670                 1675                        

gaa agc  ttt ttt gag gtt cct  gca acc acc att tat  cca gtt tct        5398
Glu Ser  Phe Phe Glu Val Pro  Ala Thr Thr Ile Tyr  Pro Val Ser            
    1680                 1685                 1690                        

gaa caa  cct tct gca aaa gtg  gtg cct acc aag ttt  gta agt gaa        5443
Glu Gln  Pro Ser Ala Lys Val  Val Pro Thr Lys Phe  Val Ser Glu            
    1695                 1700                 1705                        

aca gac  act tct gag tgg att  tcc agt acc act gtt  gag gaa aag        5488
Thr Asp  Thr Ser Glu Trp Ile  Ser Ser Thr Thr Val  Glu Glu Lys            
    1710                 1715                 1720                        

aaa agg  aag gag gag gag gga  act aca ggt acg gct  tct aca ttt        5533
Lys Arg  Lys Glu Glu Glu Gly  Thr Thr Gly Thr Ala  Ser Thr Phe            
    1725                 1730                 1735                        

gag gta  tat tca tct aca cag  aga tcg gat caa tta  att tta ccc        5578
Glu Val  Tyr Ser Ser Thr Gln  Arg Ser Asp Gln Leu  Ile Leu Pro            
    1740                 1745                 1750                        

ttt gaa  tta gaa agt cca aat  gta gct aca tct agt  gat tca ggt        5623
Phe Glu  Leu Glu Ser Pro Asn  Val Ala Thr Ser Ser  Asp Ser Gly            
    1755                 1760                 1765                        

acc agg  aaa agt ttt atg tcc  ttg aca aca cca aca  cag tct gaa        5668
Thr Arg  Lys Ser Phe Met Ser  Leu Thr Thr Pro Thr  Gln Ser Glu            
    1770                 1775                 1780                        

agg gaa  atg aca gat tct act  cct gtc ttt aca gaa  aca aat aca        5713
Arg Glu  Met Thr Asp Ser Thr  Pro Val Phe Thr Glu  Thr Asn Thr            
    1785                 1790                 1795                        

tta gaa  aat ttg ggg gca cag  acc act gag cac agc  agt atc cat        5758
Leu Glu  Asn Leu Gly Ala Gln  Thr Thr Glu His Ser  Ser Ile His            
    1800                 1805                 1810                        

caa cct  ggg gtt cag gaa ggg  ctg acc act ctc cca  cgt agt cct        5803
Gln Pro  Gly Val Gln Glu Gly  Leu Thr Thr Leu Pro  Arg Ser Pro            
    1815                 1820                 1825                        

gcc tct  gtc ttt atg gag cag  ggc tct gga gaa gct  gct gcc gac        5848
Ala Ser  Val Phe Met Glu Gln  Gly Ser Gly Glu Ala  Ala Ala Asp            
    1830                 1835                 1840                        

cca gaa  acc acc act gtt tct  tca ttt tca tta aac  gta gag tat        5893
Pro Glu  Thr Thr Thr Val Ser  Ser Phe Ser Leu Asn  Val Glu Tyr            
    1845                 1850                 1855                        

gca att  caa gcc gaa aag gaa  gta gct ggc act ttg  tct ccg cat        5938
Ala Ile  Gln Ala Glu Lys Glu  Val Ala Gly Thr Leu  Ser Pro His            
    1860                 1865                 1870                        

gtg gaa  act aca ttc tcc act  gag cca aca gga ctg  gtt ttg agt        5983
Val Glu  Thr Thr Phe Ser Thr  Glu Pro Thr Gly Leu  Val Leu Ser            
    1875                 1880                 1885                        

aca gta  atg gac aga gta gtt  gct gaa aat ata acc  caa aca tcc        6028
Thr Val  Met Asp Arg Val Val  Ala Glu Asn Ile Thr  Gln Thr Ser            
    1890                 1895                 1900                        

agg gaa  ata gtg att tca gag  cga tta gga gaa cca  aat tat ggg        6073
Arg Glu  Ile Val Ile Ser Glu  Arg Leu Gly Glu Pro  Asn Tyr Gly            
    1905                 1910                 1915                        

gca gaa  ata agg ggc ttt tcc  aca ggt ttt cct ttg  gag gaa gat        6118
Ala Glu  Ile Arg Gly Phe Ser  Thr Gly Phe Pro Leu  Glu Glu Asp            
    1920                 1925                 1930                        

ttc agt  ggt gac ttt aga gaa  tac tca aca gtg tct  cat ccc ata        6163
Phe Ser  Gly Asp Phe Arg Glu  Tyr Ser Thr Val Ser  His Pro Ile            
    1935                 1940                 1945                        

gca aaa  gaa gaa acg gta atg  atg gaa ggc tct gga  gat gca gca        6208
Ala Lys  Glu Glu Thr Val Met  Met Glu Gly Ser Gly  Asp Ala Ala            
    1950                 1955                 1960                        

ttt agg  gac acc cag act tca  cca tct aca gta cct  act tca gtt        6253
Phe Arg  Asp Thr Gln Thr Ser  Pro Ser Thr Val Pro  Thr Ser Val            
    1965                 1970                 1975                        

cac atc  agt cac ata tct gac  tca gaa gga ccc agt  agc acc atg        6298
His Ile  Ser His Ile Ser Asp  Ser Glu Gly Pro Ser  Ser Thr Met            
    1980                 1985                 1990                        

gtc agc  act tca gcc ttc ccc  tgg gaa gag ttt aca  tcc tca gct        6343
Val Ser  Thr Ser Ala Phe Pro  Trp Glu Glu Phe Thr  Ser Ser Ala            
    1995                 2000                 2005                        

gag ggc  tca ggt gag caa ctg  gtc aca gtc agc agc  tct gtt gtt        6388
Glu Gly  Ser Gly Glu Gln Leu  Val Thr Val Ser Ser  Ser Val Val            
    2010                 2015                 2020                        

cca gtg  ctt ccc agt gct gtg  caa aag ttt tct ggt  aca gct tcc        6433
Pro Val  Leu Pro Ser Ala Val  Gln Lys Phe Ser Gly  Thr Ala Ser            
    2025                 2030                 2035                        

tcc att  atc gac gaa gga ttg  gga gaa gtg ggt act  gtc aat gaa        6478
Ser Ile  Ile Asp Glu Gly Leu  Gly Glu Val Gly Thr  Val Asn Glu            
    2040                 2045                 2050                        

att gat  aga aga tcc acc att  tta cca aca gca gaa  gtg gaa ggt        6523
Ile Asp  Arg Arg Ser Thr Ile  Leu Pro Thr Ala Glu  Val Glu Gly            
    2055                 2060                 2065                        

acg aaa  gct cca gta gag aag  gag gaa gta aag gtc  agt ggc aca        6568
Thr Lys  Ala Pro Val Glu Lys  Glu Glu Val Lys Val  Ser Gly Thr            
    2070                 2075                 2080                        

gtt tca  aca aac ttt ccc caa  act ata gag cca gcc  aaa tta tgg        6613
Val Ser  Thr Asn Phe Pro Gln  Thr Ile Glu Pro Ala  Lys Leu Trp            
    2085                 2090                 2095                        

tct agg  caa gaa gtc aac cct  gta aga caa gaa att  gaa agt gaa        6658
Ser Arg  Gln Glu Val Asn Pro  Val Arg Gln Glu Ile  Glu Ser Glu            
    2100                 2105                 2110                        

aca aca  tca gag gaa caa att  caa gaa gaa aag tca  ttt gaa tcc        6703
Thr Thr  Ser Glu Glu Gln Ile  Gln Glu Glu Lys Ser  Phe Glu Ser            
    2115                 2120                 2125                        

cct caa  aac tct cct gca aca  gaa caa aca atc ttt  gat tca cag        6748
Pro Gln  Asn Ser Pro Ala Thr  Glu Gln Thr Ile Phe  Asp Ser Gln            
    2130                 2135                 2140                        

aca ttt  act gaa act gaa ctc  aaa acc aca gat tat  tct gta cta        6793
Thr Phe  Thr Glu Thr Glu Leu  Lys Thr Thr Asp Tyr  Ser Val Leu            
    2145                 2150                 2155                        

aca aca  aag aaa act tac agt  gat gat aaa gaa atg  aag gag gaa        6838
Thr Thr  Lys Lys Thr Tyr Ser  Asp Asp Lys Glu Met  Lys Glu Glu            
    2160                 2165                 2170                        

gac act  tct tta gtt aac atg  tct act cca gat cca  gat gca aat        6883
Asp Thr  Ser Leu Val Asn Met  Ser Thr Pro Asp Pro  Asp Ala Asn            
    2175                 2180                 2185                        

ggc ttg  gaa tct tac aca act  ctc cct gaa gct act  gaa aag tca        6928
Gly Leu  Glu Ser Tyr Thr Thr  Leu Pro Glu Ala Thr  Glu Lys Ser            
    2190                 2195                 2200                        

cat ttt  ttc tta gct act gca  tta gta act gaa tct  ata cca gct        6973
His Phe  Phe Leu Ala Thr Ala  Leu Val Thr Glu Ser  Ile Pro Ala            
    2205                 2210                 2215                        

gaa cat  gta gtc aca gat tca  cca atc aaa aag gaa  gaa agt aca        7018
Glu His  Val Val Thr Asp Ser  Pro Ile Lys Lys Glu  Glu Ser Thr            
    2220                 2225                 2230                        

aaa cat  ttt ccg aaa ggc atg  aga cca aca att caa  gag tca gat        7063
Lys His  Phe Pro Lys Gly Met  Arg Pro Thr Ile Gln  Glu Ser Asp            
    2235                 2240                 2245                        

act gag  ctc tta ttc tct gga  ctg gga tca gga gaa  gaa gtt tta        7108
Thr Glu  Leu Leu Phe Ser Gly  Leu Gly Ser Gly Glu  Glu Val Leu            
    2250                 2255                 2260                        

cct act  cta cca aca gag tca  gtg aat ttt act gaa  gtg gaa caa        7153
Pro Thr  Leu Pro Thr Glu Ser  Val Asn Phe Thr Glu  Val Glu Gln            
    2265                 2270                 2275                        

atc aat  aac aca tta tat ccc  cac act tct caa gtg  gaa agt acc        7198
Ile Asn  Asn Thr Leu Tyr Pro  His Thr Ser Gln Val  Glu Ser Thr            
    2280                 2285                 2290                        

tca agt  gac aaa att gaa gac  ttt aac aga atg gaa  aat gtg gca        7243
Ser Ser  Asp Lys Ile Glu Asp  Phe Asn Arg Met Glu  Asn Val Ala            
    2295                 2300                 2305                        

aaa gaa  gtt gga cca ctc gta  tct caa aca gac atc  ttt gaa ggt        7288
Lys Glu  Val Gly Pro Leu Val  Ser Gln Thr Asp Ile  Phe Glu Gly            
    2310                 2315                 2320                        

agt ggg  tca gta acc agc aca  aca tta ata gaa att  tta agt gac        7333
Ser Gly  Ser Val Thr Ser Thr  Thr Leu Ile Glu Ile  Leu Ser Asp            
    2325                 2330                 2335                        

act gga  gca gaa gga ccc acg  gtg gca cct ctc cct  ttc tcc acg        7378
Thr Gly  Ala Glu Gly Pro Thr  Val Ala Pro Leu Pro  Phe Ser Thr            
    2340                 2345                 2350                        

gac atc  gga cat cct caa aat  cag act gtc agg tgg  gca gaa gaa        7423
Asp Ile  Gly His Pro Gln Asn  Gln Thr Val Arg Trp  Ala Glu Glu            
    2355                 2360                 2365                        

atc cag  act agt aga cca caa  acc ata act gaa caa  gac tct aac        7468
Ile Gln  Thr Ser Arg Pro Gln  Thr Ile Thr Glu Gln  Asp Ser Asn            
    2370                 2375                 2380                        

aag aat  tct tca aca gca gaa  att aac gaa aca aca  acc tca tct        7513
Lys Asn  Ser Ser Thr Ala Glu  Ile Asn Glu Thr Thr  Thr Ser Ser            
    2385                 2390                 2395                        

act gat  ttt ctg gct aga gct  tat ggt ttt gaa atg  gcc aaa gaa        7558
Thr Asp  Phe Leu Ala Arg Ala  Tyr Gly Phe Glu Met  Ala Lys Glu            
    2400                 2405                 2410                        

ttt gtt  aca tca gca cca aaa  cca tct gac ttg tat  tat gaa cct        7603
Phe Val  Thr Ser Ala Pro Lys  Pro Ser Asp Leu Tyr  Tyr Glu Pro            
    2415                 2420                 2425                        

tct gga  gaa gga tct gga gaa  gtg gat att gtt gat  tca ttt cac        7648
Ser Gly  Glu Gly Ser Gly Glu  Val Asp Ile Val Asp  Ser Phe His            
    2430                 2435                 2440                        

act tct  gca act act cag gca  acc aga caa gaa agc  agc acc aca        7693
Thr Ser  Ala Thr Thr Gln Ala  Thr Arg Gln Glu Ser  Ser Thr Thr            
    2445                 2450                 2455                        

ttt gtt  tct gat ggg tcc ctg  gaa aaa cat cct gag  gtg cca agc        7738
Phe Val  Ser Asp Gly Ser Leu  Glu Lys His Pro Glu  Val Pro Ser            
    2460                 2465                 2470                        

gct aaa  gct gtt act gct gat  gga ttc cca aca gtt  tca gtg atg        7783
Ala Lys  Ala Val Thr Ala Asp  Gly Phe Pro Thr Val  Ser Val Met            
    2475                 2480                 2485                        

ctg cct  ctt cat tca gag cag  aac aaa agc tcc cct  gat cca act        7828
Leu Pro  Leu His Ser Glu Gln  Asn Lys Ser Ser Pro  Asp Pro Thr            
    2490                 2495                 2500                        

agc aca  ctg tca aat aca gtg  tca tat gag agg tcc  aca gac ggt        7873
Ser Thr  Leu Ser Asn Thr Val  Ser Tyr Glu Arg Ser  Thr Asp Gly            
    2505                 2510                 2515                        

agt ttc  caa gac cgt ttc agg  gaa ttc gag gat tcc  acc tta aaa        7918
Ser Phe  Gln Asp Arg Phe Arg  Glu Phe Glu Asp Ser  Thr Leu Lys            
    2520                 2525                 2530                        

cct aac  aga aaa aaa ccc act  gaa aat att atc ata  gac ctg gac        7963
Pro Asn  Arg Lys Lys Pro Thr  Glu Asn Ile Ile Ile  Asp Leu Asp            
    2535                 2540                 2545                        

aaa gag  gac aag gat tta ata  ttg aca att aca gag  agt acc atc        8008
Lys Glu  Asp Lys Asp Leu Ile  Leu Thr Ile Thr Glu  Ser Thr Ile            
    2550                 2555                 2560                        

ctt gaa  att cta cct gag ctg  aca tcg gat aaa aat  act atc ata        8053
Leu Glu  Ile Leu Pro Glu Leu  Thr Ser Asp Lys Asn  Thr Ile Ile            
    2565                 2570                 2575                        

gat att  gat cat act aaa cct  gtg tat gaa gac att  ctt gga atg        8098
Asp Ile  Asp His Thr Lys Pro  Val Tyr Glu Asp Ile  Leu Gly Met            
    2580                 2585                 2590                        

caa aca  gat ata gat aca gag  gta cca tca gaa cca  cat gac agt        8143
Gln Thr  Asp Ile Asp Thr Glu  Val Pro Ser Glu Pro  His Asp Ser            
    2595                 2600                 2605                        

aat gat  gaa agt aat gat gac  agc act caa gtt caa  gag atc tat        8188
Asn Asp  Glu Ser Asn Asp Asp  Ser Thr Gln Val Gln  Glu Ile Tyr            
    2610                 2615                 2620                        

gag gca  gct gtc aac ctt tct  tta act gag gaa aca  ttt gag ggc        8233
Glu Ala  Ala Val Asn Leu Ser  Leu Thr Glu Glu Thr  Phe Glu Gly            
    2625                 2630                 2635                        

tct gct  gat gtt ctg gct agc  tac act cag gca aca  cat gat gaa        8278
Ser Ala  Asp Val Leu Ala Ser  Tyr Thr Gln Ala Thr  His Asp Glu            
    2640                 2645                 2650                        

tca atg  act tat gaa gat aga  agc caa cta gat cac  atg ggc ttt        8323
Ser Met  Thr Tyr Glu Asp Arg  Ser Gln Leu Asp His  Met Gly Phe            
    2655                 2660                 2665                        

cac ttc  aca act ggg atc cct  gct cct agc aca gaa  aca gaa tta        8368
His Phe  Thr Thr Gly Ile Pro  Ala Pro Ser Thr Glu  Thr Glu Leu            
    2670                 2675                 2680                        

gac gtt  tta ctt ccc acg gca  aca tcc ctg cca att  cct cgt aag        8413
Asp Val  Leu Leu Pro Thr Ala  Thr Ser Leu Pro Ile  Pro Arg Lys            
    2685                 2690                 2695                        

tct gcc  aca gtt att cca gag  att gaa gga ata aaa  gct gaa gca        8458
Ser Ala  Thr Val Ile Pro Glu  Ile Glu Gly Ile Lys  Ala Glu Ala            
    2700                 2705                 2710                        

aaa gcc  ctg gat gac atg ttt  gaa tca agc act ttg  tct gat ggt        8503
Lys Ala  Leu Asp Asp Met Phe  Glu Ser Ser Thr Leu  Ser Asp Gly            
    2715                 2720                 2725                        

caa gct  att gca gac caa agt  gaa ata ata cca aca  ttg ggc caa        8548
Gln Ala  Ile Ala Asp Gln Ser  Glu Ile Ile Pro Thr  Leu Gly Gln            
    2730                 2735                 2740                        

ttt gaa  agg act cag gag gag  tat gaa gac aaa aaa  cat gct ggt        8593
Phe Glu  Arg Thr Gln Glu Glu  Tyr Glu Asp Lys Lys  His Ala Gly            
    2745                 2750                 2755                        

cct tct  ttt cag cca gaa ttc  tct tca gga gct gag  gag gca tta        8638
Pro Ser  Phe Gln Pro Glu Phe  Ser Ser Gly Ala Glu  Glu Ala Leu            
    2760                 2765                 2770                        

gta gac  cat act ccc tat cta  agt att gct act acc  cac ctt atg        8683
Val Asp  His Thr Pro Tyr Leu  Ser Ile Ala Thr Thr  His Leu Met            
    2775                 2780                 2785                        

gat cag  agt gta aca gag gtg  cct gat gtg atg gaa  gga tcc aat        8728
Asp Gln  Ser Val Thr Glu Val  Pro Asp Val Met Glu  Gly Ser Asn            
    2790                 2795                 2800                        

ccc cca  tat tac act gat aca  aca tta gca gtt tca  aca ttt gcg        8773
Pro Pro  Tyr Tyr Thr Asp Thr  Thr Leu Ala Val Ser  Thr Phe Ala            
    2805                 2810                 2815                        

aag ttg  tct tct cag aca cca  tca tct ccc ctc act  atc tac tca        8818
Lys Leu  Ser Ser Gln Thr Pro  Ser Ser Pro Leu Thr  Ile Tyr Ser            
    2820                 2825                 2830                        

ggc agt  gaa gcc tct gga cac  aca gag atc ccc cag  ccc agt gct        8863
Gly Ser  Glu Ala Ser Gly His  Thr Glu Ile Pro Gln  Pro Ser Ala            
    2835                 2840                 2845                        

ctg cca  gga ata gac gtc ggc  tca tct gta atg tcc  cca cag gat        8908
Leu Pro  Gly Ile Asp Val Gly  Ser Ser Val Met Ser  Pro Gln Asp            
    2850                 2855                 2860                        

tct ttt  aag gaa att cat gta  aat att gaa gcg act  ttc aaa cca        8953
Ser Phe  Lys Glu Ile His Val  Asn Ile Glu Ala Thr  Phe Lys Pro            
    2865                 2870                 2875                        

tca agt  gag gaa tac ctt cac  ata act gag cct ccc  tct tta tct        8998
Ser Ser  Glu Glu Tyr Leu His  Ile Thr Glu Pro Pro  Ser Leu Ser            
    2880                 2885                 2890                        

cct gac  aca aaa tta gaa cct  tca gaa gat gat ggt  aaa cct gag        9043
Pro Asp  Thr Lys Leu Glu Pro  Ser Glu Asp Asp Gly  Lys Pro Glu            
    2895                 2900                 2905                        

tta tta  gaa gaa atg gaa gct  tct ccc aca gaa ctt  att gct gtg        9088
Leu Leu  Glu Glu Met Glu Ala  Ser Pro Thr Glu Leu  Ile Ala Val            
    2910                 2915                 2920                        

gaa gga  act gag att ctc caa  gat ttc caa aac aaa  acc gat ggt        9133
Glu Gly  Thr Glu Ile Leu Gln  Asp Phe Gln Asn Lys  Thr Asp Gly            
    2925                 2930                 2935                        

caa gtt  tct gga gaa gca atc  aag atg ttt ccc acc  att aaa aca        9178
Gln Val  Ser Gly Glu Ala Ile  Lys Met Phe Pro Thr  Ile Lys Thr            
    2940                 2945                 2950                        

cct gag  gct gga act gtt att  aca act gcc gat gaa  att gaa tta        9223
Pro Glu  Ala Gly Thr Val Ile  Thr Thr Ala Asp Glu  Ile Glu Leu            
    2955                 2960                 2965                        

gaa ggt  gct aca cag tgg cca  cac tct act tct gct  tct gcc acc        9268
Glu Gly  Ala Thr Gln Trp Pro  His Ser Thr Ser Ala  Ser Ala Thr            
    2970                 2975                 2980                        

tat ggg  gtc gag gca ggt gtg  gtg cct tgg cta agt  cca cag act        9313
Tyr Gly  Val Glu Ala Gly Val  Val Pro Trp Leu Ser  Pro Gln Thr            
    2985                 2990                 2995                        

tct gag  agg ccc acg ctt tct  tct tct cca gaa ata  aac cct gaa        9358
Ser Glu  Arg Pro Thr Leu Ser  Ser Ser Pro Glu Ile  Asn Pro Glu            
    3000                 3005                 3010                        

act caa  gca gct tta atc aga  ggg cag gat tcc acg  ata gca gca        9403
Thr Gln  Ala Ala Leu Ile Arg  Gly Gln Asp Ser Thr  Ile Ala Ala            
    3015                 3020                 3025                        

tca gaa  cag caa gtg gca gcg  aga att ctt gat tcc  aat gat cag        9448
Ser Glu  Gln Gln Val Ala Ala  Arg Ile Leu Asp Ser  Asn Asp Gln            
    3030                 3035                 3040                        

gca aca  gta aac cct gtg gaa  ttt aat act gag gtt  gca aca cca        9493
Ala Thr  Val Asn Pro Val Glu  Phe Asn Thr Glu Val  Ala Thr Pro            
    3045                 3050                 3055                        

cca ttt  tcc ctt ctg gag act  tct aat gaa aca gat  ttc ctg att        9538
Pro Phe  Ser Leu Leu Glu Thr  Ser Asn Glu Thr Asp  Phe Leu Ile            
    3060                 3065                 3070                        

ggc att  aat gaa gag tca gtg  gaa ggc acg gca atc  tat tta cca        9583
Gly Ile  Asn Glu Glu Ser Val  Glu Gly Thr Ala Ile  Tyr Leu Pro            
    3075                 3080                 3085                        

gga cct  gat cgc tgc aaa atg  aac ccg tgc ctt aac  gga ggc acc        9628
Gly Pro  Asp Arg Cys Lys Met  Asn Pro Cys Leu Asn  Gly Gly Thr            
    3090                 3095                 3100                        

tgt tat  cct act gaa act tcc  tac gta tgc acc tgt  gtg cca gga        9673
Cys Tyr  Pro Thr Glu Thr Ser  Tyr Val Cys Thr Cys  Val Pro Gly            
    3105                 3110                 3115                        

tac agc  gga gac cag tgt gaa  ctt gat ttt gat gaa  tgt cac tct        9718
Tyr Ser  Gly Asp Gln Cys Glu  Leu Asp Phe Asp Glu  Cys His Ser            
    3120                 3125                 3130                        

aat ccc  tgt cgt aat gga gcc  act tgt gtt gat ggt  ttt aac aca        9763
Asn Pro  Cys Arg Asn Gly Ala  Thr Cys Val Asp Gly  Phe Asn Thr            
    3135                 3140                 3145                        

ttc agg  tgc ctc tgc ctt cca  agt tat gtt ggt gca  ctt tgt gag        9808
Phe Arg  Cys Leu Cys Leu Pro  Ser Tyr Val Gly Ala  Leu Cys Glu            
    3150                 3155                 3160                        

caa gat  acc gag aca tgt gac  tat ggc tgg cac aaa  ttc caa ggg        9853
Gln Asp  Thr Glu Thr Cys Asp  Tyr Gly Trp His Lys  Phe Gln Gly            
    3165                 3170                 3175                        

cag tgc  tac aaa tac ttt gcc  cat cga cgc aca tgg  gat gca gct        9898
Gln Cys  Tyr Lys Tyr Phe Ala  His Arg Arg Thr Trp  Asp Ala Ala            
    3180                 3185                 3190                        

gaa cgg  gaa tgc cgt ctg cag  ggt gcc cat ctc aca  agc atc ctg        9943
Glu Arg  Glu Cys Arg Leu Gln  Gly Ala His Leu Thr  Ser Ile Leu            
    3195                 3200                 3205                        

tct cac  gaa gaa caa atg ttt  gtt aat cgt gtg ggc  cat gat tat        9988
Ser His  Glu Glu Gln Met Phe  Val Asn Arg Val Gly  His Asp Tyr            
    3210                 3215                 3220                        

cag tgg  ata ggc ctc aat gac  aag atg ttt gag cat  gac ttc cgt       10033
Gln Trp  Ile Gly Leu Asn Asp  Lys Met Phe Glu His  Asp Phe Arg            
    3225                 3230                 3235                        

tgg act  gat ggc agc aca ctg  caa tac gag aat tgg  aga ccc aac       10078
Trp Thr  Asp Gly Ser Thr Leu  Gln Tyr Glu Asn Trp  Arg Pro Asn            
    3240                 3245                 3250                        

cag cca  gac agc ttc ttt tct  gct gga gaa gac tgt  gtt gta atc       10123
Gln Pro  Asp Ser Phe Phe Ser  Ala Gly Glu Asp Cys  Val Val Ile            
    3255                 3260                 3265                        

att tgg  cat gag aat ggc cag  tgg aat gat gtt ccc  tgc aat tac       10168
Ile Trp  His Glu Asn Gly Gln  Trp Asn Asp Val Pro  Cys Asn Tyr            
    3270                 3275                 3280                        

cat ctc  acc tat acg tgc aag  aaa gga aca gtc gct  tgc ggc cag       10213
His Leu  Thr Tyr Thr Cys Lys  Lys Gly Thr Val Ala  Cys Gly Gln            
    3285                 3290                 3295                        

ccc cct  gtt gta gaa aat gcc  aag acc ttt gga aag  atg aaa cct       10258
Pro Pro  Val Val Glu Asn Ala  Lys Thr Phe Gly Lys  Met Lys Pro            
    3300                 3305                 3310                        

cgt tat  gaa atc aac tcc ctg  att aga tac cac tgc  aaa gat ggt       10303
Arg Tyr  Glu Ile Asn Ser Leu  Ile Arg Tyr His Cys  Lys Asp Gly            
    3315                 3320                 3325                        

ttc att  caa cgt cac ctt cca  act atc cgg tgc tta  gga aat gga       10348
Phe Ile  Gln Arg His Leu Pro  Thr Ile Arg Cys Leu  Gly Asn Gly            
    3330                 3335                 3340                        

aga tgg  gct ata cct aaa att  acc tgc atg aac cca  tct gca tac       10393
Arg Trp  Ala Ile Pro Lys Ile  Thr Cys Met Asn Pro  Ser Ala Tyr            
    3345                 3350                 3355                        

caa agg  act tat tct atg aaa  tac ttt aaa aat tcc  tca tca gca       10438
Gln Arg  Thr Tyr Ser Met Lys  Tyr Phe Lys Asn Ser  Ser Ser Ala            
    3360                 3365                 3370                        

aag gac  aat tca ata aat aca  tcc aaa cat gat cat  cgt tgg agc       10483
Lys Asp  Asn Ser Ile Asn Thr  Ser Lys His Asp His  Arg Trp Ser            
    3375                 3380                 3385                        

cgg agg  tgg cag gag tcg agg  cgc tga tccctaaaat ggcgaacatg          10530
Arg Arg  Trp Gln Glu Ser Arg  Arg                                         
    3390                 3395                                             

tgttttcatc atttcagcca aagtcctaac ttcctgtgcc tttcctatca cctcgagaag    10590

taattatcag ttggtttgga tttttggacc accgttcagt cattttgggt tgccgtgctc    10650

ccaaaacatt ttaaatgaaa gtattggcat tcaaaaagac agcagacaaa atgaaagaaa    10710

atgagagcag aaagtaagca tttccagcct atctaatttc tttagttttc tatttgcctc    10770

cagtgcagtc catttcctaa tgtataccag cctactgtac tatttaaaat gctcaatttc    10830

agcaccgatg gccatgtaaa taagatgatt taatgttgat tttaatcctg tatataaaat    10890

aaaaagtcac aatgagtttg ggcatattta atgatgatta tggagcctta gaggtcttta    10950

atcattggtt cggctgcttt tatgtagttt aggctggaaa tggtttcact tgctctttga    11010

ctgtcagcaa gactgaagat ggcttttcct ggacagctag aaaacacaaa atcttgtagg    11070

tcattgcacc tatctcagcc ataggtgcag tttgcttcta catgatgcta aaggctgcga    11130

atgggatcct gatggaacta aggactccaa tgtcgaactc ttctttgctg cattcctttt    11190

tcttcactta caagaaaggc ctgaatggag gacttttctg taaccaggaa cattttttag    11250

gggtcaaagt gctaataatt aactcaacca ggtctacttt ttaatggctt tcataacact    11310

aactcataag gttaccgatc aatgcatttc atacggatat agacctaggg ctctggaggg    11370

tgggggattg ttaaaacaca tgcaaaaaaa aaaaaaaaaa aaaaaaaaga aattttgtat    11430

atataaccat tttaatcttt tataaagttt tgaatgttca tgtatgaatg ctgcagctgt    11490

gaagcataca taaataaatg aagtaagcca tactgattta atttattgga tgttattttc    11550

cctaagacct gaaaatgaac atagtatgct agttattttt cagtgttagc cttttacttt    11610

cctcacacaa tttggaatca tataatatag gtactttgtc cctgattaaa taatgtgacg    11670

gatagaatgc atcaagtgtt tattatgaaa agagtggaaa agtatatagc ttttagcaaa    11730

aggtgtttgc ccattctaag aaatgagcga atatatagaa atagtgtggg catttcttcc    11790

tgttaggtgg agtgtatgtg ttgacatttc tccccatctc ttcccactct gttttctccc    11850

cattatttga ataaagtgac tgctgaagat gactttgaat ccttatccac ttaatttaat    11910

gtttaaagaa aaacctgtaa tggaaagtaa gactccttcc ctaatttcag tttagagcaa    11970

cttgaagaag agtagacaaa aaataaaatg cacatagaaa aagagaaaaa gggcacaaag    12030

ggattggccc aatattgatt ctttttt                                        12057


<210>  700
<211>  3396
<212>  PRT
<213>  Homo sapiens

<400>  700

Met Phe Ile Asn Ile Lys Ser Ile Leu Trp Met Cys Ser Thr Leu Ile 
1               5                   10                  15      


Val Thr His Ala Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val 
            20                  25                  30          


Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr 
        35                  40                  45              


Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile 
    50                  55                  60                  


Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu 
65                  70                  75                  80  


Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp 
                85                  90                  95      


Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp 
            100                 105                 110         


Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr 
        115                 120                 125             


Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser 
    130                 135                 140                 


Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg 
145                 150                 155                 160 


Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly 
                165                 170                 175     


Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly 
            180                 185                 190         


Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr 
        195                 200                 205             


Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys 
    210                 215                 220                 


Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp 
225                 230                 235                 240 


Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr 
                245                 250                 255     


Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn 
            260                 265                 270         


Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg 
        275                 280                 285             


Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val 
    290                 295                 300                 


Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu 
305                 310                 315                 320 


Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro 
                325                 330                 335     


Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Ala Thr 
            340                 345                 350         


Thr Ile Asp Leu Ser Ile Leu Ala Glu Thr Ala Ser Pro Ser Leu Ser 
        355                 360                 365             


Lys Glu Pro Gln Met Val Ser Asp Arg Thr Thr Pro Ile Ile Pro Leu 
    370                 375                 380                 


Val Asp Glu Leu Pro Val Ile Pro Thr Glu Phe Pro Pro Val Gly Asn 
385                 390                 395                 400 


Ile Val Ser Phe Glu Gln Lys Ala Thr Val Gln Pro Gln Ala Ile Thr 
                405                 410                 415     


Asp Ser Leu Ala Thr Lys Leu Pro Thr Pro Thr Gly Ser Thr Lys Lys 
            420                 425                 430         


Pro Trp Asp Met Asp Asp Tyr Ser Pro Ser Ala Ser Gly Pro Leu Gly 
        435                 440                 445             


Lys Leu Asp Ile Ser Glu Ile Lys Glu Glu Val Leu Gln Ser Thr Thr 
    450                 455                 460                 


Gly Val Ser His Tyr Ala Thr Asp Ser Trp Asp Gly Val Val Glu Asp 
465                 470                 475                 480 


Lys Gln Thr Gln Glu Ser Val Thr Gln Ile Glu Gln Ile Glu Val Gly 
                485                 490                 495     


Pro Leu Val Thr Ser Met Glu Ile Leu Lys His Ile Pro Ser Lys Glu 
            500                 505                 510         


Phe Pro Val Thr Glu Thr Pro Leu Val Thr Ala Arg Met Ile Leu Glu 
        515                 520                 525             


Ser Lys Thr Glu Lys Lys Met Val Ser Thr Val Ser Glu Leu Val Thr 
    530                 535                 540                 


Thr Gly His Tyr Gly Phe Thr Leu Gly Glu Glu Asp Asp Glu Asp Arg 
545                 550                 555                 560 


Thr Leu Thr Val Gly Ser Asp Glu Ser Thr Leu Ile Phe Asp Gln Ile 
                565                 570                 575     


Pro Glu Val Ile Thr Val Ser Lys Thr Ser Glu Asp Thr Ile His Thr 
            580                 585                 590         


His Leu Glu Asp Leu Glu Ser Val Ser Ala Ser Thr Thr Val Ser Pro 
        595                 600                 605             


Leu Ile Met Pro Asp Asn Asn Gly Ser Ser Met Asp Asp Trp Glu Glu 
    610                 615                 620                 


Arg Gln Thr Ser Gly Arg Ile Thr Glu Glu Phe Leu Gly Lys Tyr Leu 
625                 630                 635                 640 


Ser Thr Thr Pro Phe Pro Ser Gln His Arg Thr Glu Ile Glu Leu Phe 
                645                 650                 655     


Pro Tyr Ser Gly Asp Lys Ile Leu Val Glu Gly Ile Ser Thr Val Ile 
            660                 665                 670         


Tyr Pro Ser Leu Gln Thr Glu Met Thr His Arg Arg Glu Arg Thr Glu 
        675                 680                 685             


Thr Leu Ile Pro Glu Met Arg Thr Asp Thr Tyr Thr Asp Glu Ile Gln 
    690                 695                 700                 


Glu Glu Ile Thr Lys Ser Pro Phe Met Gly Lys Thr Glu Glu Glu Val 
705                 710                 715                 720 


Phe Ser Gly Met Lys Leu Ser Thr Ser Leu Ser Glu Pro Ile His Val 
                725                 730                 735     


Thr Glu Ser Ser Val Glu Met Thr Lys Ser Phe Asp Phe Pro Thr Leu 
            740                 745                 750         


Ile Thr Lys Leu Ser Ala Glu Pro Thr Glu Val Arg Asp Met Glu Glu 
        755                 760                 765             


Asp Phe Thr Ala Thr Pro Gly Thr Thr Lys Tyr Asp Glu Asn Ile Thr 
    770                 775                 780                 


Thr Val Leu Leu Ala His Gly Thr Leu Ser Val Glu Ala Ala Thr Val 
785                 790                 795                 800 


Ser Lys Trp Ser Trp Asp Glu Asp Asn Thr Thr Ser Lys Pro Leu Glu 
                805                 810                 815     


Ser Thr Glu Pro Ser Ala Ser Ser Lys Leu Pro Pro Ala Leu Leu Thr 
            820                 825                 830         


Thr Val Gly Met Asn Gly Lys Asp Lys Asp Ile Pro Ser Phe Thr Glu 
        835                 840                 845             


Asp Gly Ala Asp Glu Phe Thr Leu Ile Pro Asp Ser Thr Gln Lys Gln 
    850                 855                 860                 


Leu Glu Glu Val Thr Asp Glu Asp Ile Ala Ala His Gly Lys Phe Thr 
865                 870                 875                 880 


Ile Arg Phe Gln Pro Thr Thr Ser Thr Gly Ile Ala Glu Lys Ser Thr 
                885                 890                 895     


Leu Arg Asp Ser Thr Thr Glu Glu Lys Val Pro Pro Ile Thr Ser Thr 
            900                 905                 910         


Glu Gly Gln Val Tyr Ala Thr Met Glu Gly Ser Ala Leu Gly Glu Val 
        915                 920                 925             


Glu Asp Val Asp Leu Ser Lys Pro Val Ser Thr Val Pro Gln Phe Ala 
    930                 935                 940                 


His Thr Ser Glu Val Glu Gly Leu Ala Phe Val Ser Tyr Ser Ser Thr 
945                 950                 955                 960 


Gln Glu Pro Thr Thr Tyr Val Asp Ser Ser His Thr Ile Pro Leu Ser 
                965                 970                 975     


Val Ile Pro Lys Thr Asp Trp Gly Val Leu Val Pro Ser Val Pro Ser 
            980                 985                 990         


Glu Asp Glu Val Leu Gly Glu Pro  Ser Gln Asp Ile Leu  Val Ile Asp 
        995                 1000                 1005             


Gln Thr  Arg Leu Glu Ala Thr  Ile Ser Pro Glu Thr  Met Arg Thr 
    1010                 1015                 1020             


Thr Lys  Ile Thr Glu Gly Thr  Thr Gln Glu Glu Phe  Pro Trp Lys 
    1025                 1030                 1035             


Glu Gln  Thr Ala Glu Lys Pro  Val Pro Ala Leu Ser  Ser Thr Ala 
    1040                 1045                 1050             


Trp Thr  Pro Lys Glu Ala Val  Thr Pro Leu Asp Glu  Gln Glu Gly 
    1055                 1060                 1065             


Asp Gly  Ser Ala Tyr Thr Val  Ser Glu Asp Glu Leu  Leu Thr Gly 
    1070                 1075                 1080             


Ser Glu  Arg Val Pro Val Leu  Glu Thr Thr Pro Val  Gly Lys Ile 
    1085                 1090                 1095             


Asp His  Ser Val Ser Tyr Pro  Pro Gly Ala Val Thr  Glu His Lys 
    1100                 1105                 1110             


Val Lys  Thr Asp Glu Val Val  Thr Leu Thr Pro Arg  Ile Gly Pro 
    1115                 1120                 1125             


Lys Val  Ser Leu Ser Pro Gly  Pro Glu Gln Lys Tyr  Glu Thr Glu 
    1130                 1135                 1140             


Gly Ser  Ser Thr Thr Gly Phe  Thr Ser Ser Leu Ser  Pro Phe Ser 
    1145                 1150                 1155             


Thr His  Ile Thr Gln Leu Met  Glu Glu Thr Thr Thr  Glu Lys Thr 
    1160                 1165                 1170             


Ser Leu  Glu Asp Ile Asp Leu  Gly Ser Gly Leu Phe  Glu Lys Pro 
    1175                 1180                 1185             


Lys Ala  Thr Glu Leu Ile Glu  Phe Ser Thr Ile Lys  Val Thr Val 
    1190                 1195                 1200             


Pro Ser  Asp Ile Thr Thr Ala  Phe Ser Ser Val Asp  Arg Leu His 
    1205                 1210                 1215             


Thr Thr  Ser Ala Phe Lys Pro  Ser Ser Ala Ile Thr  Lys Lys Pro 
    1220                 1225                 1230             


Pro Leu  Ile Asp Arg Glu Pro  Gly Glu Glu Thr Thr  Ser Asp Met 
    1235                 1240                 1245             


Val Ile  Ile Gly Glu Ser Thr  Ser His Val Pro Pro  Thr Thr Leu 
    1250                 1255                 1260             


Glu Asp  Ile Val Ala Lys Glu  Thr Glu Thr Asp Ile  Asp Arg Glu 
    1265                 1270                 1275             


Tyr Phe  Thr Thr Ser Ser Pro  Pro Ala Thr Gln Pro  Thr Arg Pro 
    1280                 1285                 1290             


Pro Thr  Val Glu Asp Lys Glu  Ala Phe Gly Pro Gln  Ala Leu Ser 
    1295                 1300                 1305             


Thr Pro  Gln Pro Pro Ala Ser  Thr Lys Phe His Pro  Asp Ile Asn 
    1310                 1315                 1320             


Val Tyr  Ile Ile Glu Val Arg  Glu Asn Lys Thr Gly  Arg Met Ser 
    1325                 1330                 1335             


Asp Leu  Ser Val Ile Gly His  Pro Ile Asp Ser Glu  Ser Lys Glu 
    1340                 1345                 1350             


Asp Glu  Pro Cys Ser Glu Glu  Thr Asp Pro Val His  Asp Leu Met 
    1355                 1360                 1365             


Ala Glu  Ile Leu Pro Glu Phe  Pro Asp Ile Ile Glu  Ile Asp Leu 
    1370                 1375                 1380             


Tyr His  Ser Glu Glu Asn Glu  Glu Glu Glu Glu Glu  Cys Ala Asn 
    1385                 1390                 1395             


Ala Thr  Asp Val Thr Thr Thr  Pro Ser Val Gln Tyr  Ile Asn Gly 
    1400                 1405                 1410             


Lys His  Leu Val Thr Thr Val  Pro Lys Asp Pro Glu  Ala Ala Glu 
    1415                 1420                 1425             


Ala Arg  Arg Gly Gln Phe Glu  Ser Val Ala Pro Ser  Gln Asn Phe 
    1430                 1435                 1440             


Ser Asp  Ser Ser Glu Ser Asp  Thr His Pro Phe Val  Ile Ala Lys 
    1445                 1450                 1455             


Thr Glu  Leu Ser Thr Ala Val  Gln Pro Asn Glu Ser  Thr Glu Thr 
    1460                 1465                 1470             


Thr Glu  Ser Leu Glu Val Thr  Trp Lys Pro Glu Thr  Tyr Pro Glu 
    1475                 1480                 1485             


Thr Ser  Glu His Phe Ser Gly  Gly Glu Pro Asp Val  Phe Pro Thr 
    1490                 1495                 1500             


Val Pro  Phe His Glu Glu Phe  Glu Ser Gly Thr Ala  Lys Lys Gly 
    1505                 1510                 1515             


Ala Glu  Ser Val Thr Glu Arg  Asp Thr Glu Val Gly  His Gln Ala 
    1520                 1525                 1530             


His Glu  His Thr Glu Pro Val  Ser Leu Phe Pro Glu  Glu Ser Ser 
    1535                 1540                 1545             


Gly Glu  Ile Ala Ile Asp Gln  Glu Ser Gln Lys Ile  Ala Phe Ala 
    1550                 1555                 1560             


Arg Ala  Thr Glu Val Thr Phe  Gly Glu Glu Val Glu  Lys Ser Thr 
    1565                 1570                 1575             


Ser Val  Thr Tyr Thr Pro Thr  Ile Val Pro Ser Ser  Ala Ser Ala 
    1580                 1585                 1590             


Tyr Val  Ser Glu Glu Glu Ala  Val Thr Leu Ile Gly  Asn Pro Trp 
    1595                 1600                 1605             


Pro Asp  Asp Leu Leu Ser Thr  Lys Glu Ser Trp Val  Glu Ala Thr 
    1610                 1615                 1620             


Pro Arg  Gln Val Val Glu Leu  Ser Gly Ser Ser Ser  Ile Pro Ile 
    1625                 1630                 1635             


Thr Glu  Gly Ser Gly Glu Ala  Glu Glu Asp Glu Asp  Thr Met Phe 
    1640                 1645                 1650             


Thr Met  Val Thr Asp Leu Ser  Gln Arg Asn Thr Thr  Asp Thr Leu 
    1655                 1660                 1665             


Ile Thr  Leu Asp Thr Ser Arg  Ile Ile Thr Glu Ser  Phe Phe Glu 
    1670                 1675                 1680             


Val Pro  Ala Thr Thr Ile Tyr  Pro Val Ser Glu Gln  Pro Ser Ala 
    1685                 1690                 1695             


Lys Val  Val Pro Thr Lys Phe  Val Ser Glu Thr Asp  Thr Ser Glu 
    1700                 1705                 1710             


Trp Ile  Ser Ser Thr Thr Val  Glu Glu Lys Lys Arg  Lys Glu Glu 
    1715                 1720                 1725             


Glu Gly  Thr Thr Gly Thr Ala  Ser Thr Phe Glu Val  Tyr Ser Ser 
    1730                 1735                 1740             


Thr Gln  Arg Ser Asp Gln Leu  Ile Leu Pro Phe Glu  Leu Glu Ser 
    1745                 1750                 1755             


Pro Asn  Val Ala Thr Ser Ser  Asp Ser Gly Thr Arg  Lys Ser Phe 
    1760                 1765                 1770             


Met Ser  Leu Thr Thr Pro Thr  Gln Ser Glu Arg Glu  Met Thr Asp 
    1775                 1780                 1785             


Ser Thr  Pro Val Phe Thr Glu  Thr Asn Thr Leu Glu  Asn Leu Gly 
    1790                 1795                 1800             


Ala Gln  Thr Thr Glu His Ser  Ser Ile His Gln Pro  Gly Val Gln 
    1805                 1810                 1815             


Glu Gly  Leu Thr Thr Leu Pro  Arg Ser Pro Ala Ser  Val Phe Met 
    1820                 1825                 1830             


Glu Gln  Gly Ser Gly Glu Ala  Ala Ala Asp Pro Glu  Thr Thr Thr 
    1835                 1840                 1845             


Val Ser  Ser Phe Ser Leu Asn  Val Glu Tyr Ala Ile  Gln Ala Glu 
    1850                 1855                 1860             


Lys Glu  Val Ala Gly Thr Leu  Ser Pro His Val Glu  Thr Thr Phe 
    1865                 1870                 1875             


Ser Thr  Glu Pro Thr Gly Leu  Val Leu Ser Thr Val  Met Asp Arg 
    1880                 1885                 1890             


Val Val  Ala Glu Asn Ile Thr  Gln Thr Ser Arg Glu  Ile Val Ile 
    1895                 1900                 1905             


Ser Glu  Arg Leu Gly Glu Pro  Asn Tyr Gly Ala Glu  Ile Arg Gly 
    1910                 1915                 1920             


Phe Ser  Thr Gly Phe Pro Leu  Glu Glu Asp Phe Ser  Gly Asp Phe 
    1925                 1930                 1935             


Arg Glu  Tyr Ser Thr Val Ser  His Pro Ile Ala Lys  Glu Glu Thr 
    1940                 1945                 1950             


Val Met  Met Glu Gly Ser Gly  Asp Ala Ala Phe Arg  Asp Thr Gln 
    1955                 1960                 1965             


Thr Ser  Pro Ser Thr Val Pro  Thr Ser Val His Ile  Ser His Ile 
    1970                 1975                 1980             


Ser Asp  Ser Glu Gly Pro Ser  Ser Thr Met Val Ser  Thr Ser Ala 
    1985                 1990                 1995             


Phe Pro  Trp Glu Glu Phe Thr  Ser Ser Ala Glu Gly  Ser Gly Glu 
    2000                 2005                 2010             


Gln Leu  Val Thr Val Ser Ser  Ser Val Val Pro Val  Leu Pro Ser 
    2015                 2020                 2025             


Ala Val  Gln Lys Phe Ser Gly  Thr Ala Ser Ser Ile  Ile Asp Glu 
    2030                 2035                 2040             


Gly Leu  Gly Glu Val Gly Thr  Val Asn Glu Ile Asp  Arg Arg Ser 
    2045                 2050                 2055             


Thr Ile  Leu Pro Thr Ala Glu  Val Glu Gly Thr Lys  Ala Pro Val 
    2060                 2065                 2070             


Glu Lys  Glu Glu Val Lys Val  Ser Gly Thr Val Ser  Thr Asn Phe 
    2075                 2080                 2085             


Pro Gln  Thr Ile Glu Pro Ala  Lys Leu Trp Ser Arg  Gln Glu Val 
    2090                 2095                 2100             


Asn Pro  Val Arg Gln Glu Ile  Glu Ser Glu Thr Thr  Ser Glu Glu 
    2105                 2110                 2115             


Gln Ile  Gln Glu Glu Lys Ser  Phe Glu Ser Pro Gln  Asn Ser Pro 
    2120                 2125                 2130             


Ala Thr  Glu Gln Thr Ile Phe  Asp Ser Gln Thr Phe  Thr Glu Thr 
    2135                 2140                 2145             


Glu Leu  Lys Thr Thr Asp Tyr  Ser Val Leu Thr Thr  Lys Lys Thr 
    2150                 2155                 2160             


Tyr Ser  Asp Asp Lys Glu Met  Lys Glu Glu Asp Thr  Ser Leu Val 
    2165                 2170                 2175             


Asn Met  Ser Thr Pro Asp Pro  Asp Ala Asn Gly Leu  Glu Ser Tyr 
    2180                 2185                 2190             


Thr Thr  Leu Pro Glu Ala Thr  Glu Lys Ser His Phe  Phe Leu Ala 
    2195                 2200                 2205             


Thr Ala  Leu Val Thr Glu Ser  Ile Pro Ala Glu His  Val Val Thr 
    2210                 2215                 2220             


Asp Ser  Pro Ile Lys Lys Glu  Glu Ser Thr Lys His  Phe Pro Lys 
    2225                 2230                 2235             


Gly Met  Arg Pro Thr Ile Gln  Glu Ser Asp Thr Glu  Leu Leu Phe 
    2240                 2245                 2250             


Ser Gly  Leu Gly Ser Gly Glu  Glu Val Leu Pro Thr  Leu Pro Thr 
    2255                 2260                 2265             


Glu Ser  Val Asn Phe Thr Glu  Val Glu Gln Ile Asn  Asn Thr Leu 
    2270                 2275                 2280             


Tyr Pro  His Thr Ser Gln Val  Glu Ser Thr Ser Ser  Asp Lys Ile 
    2285                 2290                 2295             


Glu Asp  Phe Asn Arg Met Glu  Asn Val Ala Lys Glu  Val Gly Pro 
    2300                 2305                 2310             


Leu Val  Ser Gln Thr Asp Ile  Phe Glu Gly Ser Gly  Ser Val Thr 
    2315                 2320                 2325             


Ser Thr  Thr Leu Ile Glu Ile  Leu Ser Asp Thr Gly  Ala Glu Gly 
    2330                 2335                 2340             


Pro Thr  Val Ala Pro Leu Pro  Phe Ser Thr Asp Ile  Gly His Pro 
    2345                 2350                 2355             


Gln Asn  Gln Thr Val Arg Trp  Ala Glu Glu Ile Gln  Thr Ser Arg 
    2360                 2365                 2370             


Pro Gln  Thr Ile Thr Glu Gln  Asp Ser Asn Lys Asn  Ser Ser Thr 
    2375                 2380                 2385             


Ala Glu  Ile Asn Glu Thr Thr  Thr Ser Ser Thr Asp  Phe Leu Ala 
    2390                 2395                 2400             


Arg Ala  Tyr Gly Phe Glu Met  Ala Lys Glu Phe Val  Thr Ser Ala 
    2405                 2410                 2415             


Pro Lys  Pro Ser Asp Leu Tyr  Tyr Glu Pro Ser Gly  Glu Gly Ser 
    2420                 2425                 2430             


Gly Glu  Val Asp Ile Val Asp  Ser Phe His Thr Ser  Ala Thr Thr 
    2435                 2440                 2445             


Gln Ala  Thr Arg Gln Glu Ser  Ser Thr Thr Phe Val  Ser Asp Gly 
    2450                 2455                 2460             


Ser Leu  Glu Lys His Pro Glu  Val Pro Ser Ala Lys  Ala Val Thr 
    2465                 2470                 2475             


Ala Asp  Gly Phe Pro Thr Val  Ser Val Met Leu Pro  Leu His Ser 
    2480                 2485                 2490             


Glu Gln  Asn Lys Ser Ser Pro  Asp Pro Thr Ser Thr  Leu Ser Asn 
    2495                 2500                 2505             


Thr Val  Ser Tyr Glu Arg Ser  Thr Asp Gly Ser Phe  Gln Asp Arg 
    2510                 2515                 2520             


Phe Arg  Glu Phe Glu Asp Ser  Thr Leu Lys Pro Asn  Arg Lys Lys 
    2525                 2530                 2535             


Pro Thr  Glu Asn Ile Ile Ile  Asp Leu Asp Lys Glu  Asp Lys Asp 
    2540                 2545                 2550             


Leu Ile  Leu Thr Ile Thr Glu  Ser Thr Ile Leu Glu  Ile Leu Pro 
    2555                 2560                 2565             


Glu Leu  Thr Ser Asp Lys Asn  Thr Ile Ile Asp Ile  Asp His Thr 
    2570                 2575                 2580             


Lys Pro  Val Tyr Glu Asp Ile  Leu Gly Met Gln Thr  Asp Ile Asp 
    2585                 2590                 2595             


Thr Glu  Val Pro Ser Glu Pro  His Asp Ser Asn Asp  Glu Ser Asn 
    2600                 2605                 2610             


Asp Asp  Ser Thr Gln Val Gln  Glu Ile Tyr Glu Ala  Ala Val Asn 
    2615                 2620                 2625             


Leu Ser  Leu Thr Glu Glu Thr  Phe Glu Gly Ser Ala  Asp Val Leu 
    2630                 2635                 2640             


Ala Ser  Tyr Thr Gln Ala Thr  His Asp Glu Ser Met  Thr Tyr Glu 
    2645                 2650                 2655             


Asp Arg  Ser Gln Leu Asp His  Met Gly Phe His Phe  Thr Thr Gly 
    2660                 2665                 2670             


Ile Pro  Ala Pro Ser Thr Glu  Thr Glu Leu Asp Val  Leu Leu Pro 
    2675                 2680                 2685             


Thr Ala  Thr Ser Leu Pro Ile  Pro Arg Lys Ser Ala  Thr Val Ile 
    2690                 2695                 2700             


Pro Glu  Ile Glu Gly Ile Lys  Ala Glu Ala Lys Ala  Leu Asp Asp 
    2705                 2710                 2715             


Met Phe  Glu Ser Ser Thr Leu  Ser Asp Gly Gln Ala  Ile Ala Asp 
    2720                 2725                 2730             


Gln Ser  Glu Ile Ile Pro Thr  Leu Gly Gln Phe Glu  Arg Thr Gln 
    2735                 2740                 2745             


Glu Glu  Tyr Glu Asp Lys Lys  His Ala Gly Pro Ser  Phe Gln Pro 
    2750                 2755                 2760             


Glu Phe  Ser Ser Gly Ala Glu  Glu Ala Leu Val Asp  His Thr Pro 
    2765                 2770                 2775             


Tyr Leu  Ser Ile Ala Thr Thr  His Leu Met Asp Gln  Ser Val Thr 
    2780                 2785                 2790             


Glu Val  Pro Asp Val Met Glu  Gly Ser Asn Pro Pro  Tyr Tyr Thr 
    2795                 2800                 2805             


Asp Thr  Thr Leu Ala Val Ser  Thr Phe Ala Lys Leu  Ser Ser Gln 
    2810                 2815                 2820             


Thr Pro  Ser Ser Pro Leu Thr  Ile Tyr Ser Gly Ser  Glu Ala Ser 
    2825                 2830                 2835             


Gly His  Thr Glu Ile Pro Gln  Pro Ser Ala Leu Pro  Gly Ile Asp 
    2840                 2845                 2850             


Val Gly  Ser Ser Val Met Ser  Pro Gln Asp Ser Phe  Lys Glu Ile 
    2855                 2860                 2865             


His Val  Asn Ile Glu Ala Thr  Phe Lys Pro Ser Ser  Glu Glu Tyr 
    2870                 2875                 2880             


Leu His  Ile Thr Glu Pro Pro  Ser Leu Ser Pro Asp  Thr Lys Leu 
    2885                 2890                 2895             


Glu Pro  Ser Glu Asp Asp Gly  Lys Pro Glu Leu Leu  Glu Glu Met 
    2900                 2905                 2910             


Glu Ala  Ser Pro Thr Glu Leu  Ile Ala Val Glu Gly  Thr Glu Ile 
    2915                 2920                 2925             


Leu Gln  Asp Phe Gln Asn Lys  Thr Asp Gly Gln Val  Ser Gly Glu 
    2930                 2935                 2940             


Ala Ile  Lys Met Phe Pro Thr  Ile Lys Thr Pro Glu  Ala Gly Thr 
    2945                 2950                 2955             


Val Ile  Thr Thr Ala Asp Glu  Ile Glu Leu Glu Gly  Ala Thr Gln 
    2960                 2965                 2970             


Trp Pro  His Ser Thr Ser Ala  Ser Ala Thr Tyr Gly  Val Glu Ala 
    2975                 2980                 2985             


Gly Val  Val Pro Trp Leu Ser  Pro Gln Thr Ser Glu  Arg Pro Thr 
    2990                 2995                 3000             


Leu Ser  Ser Ser Pro Glu Ile  Asn Pro Glu Thr Gln  Ala Ala Leu 
    3005                 3010                 3015             


Ile Arg  Gly Gln Asp Ser Thr  Ile Ala Ala Ser Glu  Gln Gln Val 
    3020                 3025                 3030             


Ala Ala  Arg Ile Leu Asp Ser  Asn Asp Gln Ala Thr  Val Asn Pro 
    3035                 3040                 3045             


Val Glu  Phe Asn Thr Glu Val  Ala Thr Pro Pro Phe  Ser Leu Leu 
    3050                 3055                 3060             


Glu Thr  Ser Asn Glu Thr Asp  Phe Leu Ile Gly Ile  Asn Glu Glu 
    3065                 3070                 3075             


Ser Val  Glu Gly Thr Ala Ile  Tyr Leu Pro Gly Pro  Asp Arg Cys 
    3080                 3085                 3090             


Lys Met  Asn Pro Cys Leu Asn  Gly Gly Thr Cys Tyr  Pro Thr Glu 
    3095                 3100                 3105             


Thr Ser  Tyr Val Cys Thr Cys  Val Pro Gly Tyr Ser  Gly Asp Gln 
    3110                 3115                 3120             


Cys Glu  Leu Asp Phe Asp Glu  Cys His Ser Asn Pro  Cys Arg Asn 
    3125                 3130                 3135             


Gly Ala  Thr Cys Val Asp Gly  Phe Asn Thr Phe Arg  Cys Leu Cys 
    3140                 3145                 3150             


Leu Pro  Ser Tyr Val Gly Ala  Leu Cys Glu Gln Asp  Thr Glu Thr 
    3155                 3160                 3165             


Cys Asp  Tyr Gly Trp His Lys  Phe Gln Gly Gln Cys  Tyr Lys Tyr 
    3170                 3175                 3180             


Phe Ala  His Arg Arg Thr Trp  Asp Ala Ala Glu Arg  Glu Cys Arg 
    3185                 3190                 3195             


Leu Gln  Gly Ala His Leu Thr  Ser Ile Leu Ser His  Glu Glu Gln 
    3200                 3205                 3210             


Met Phe  Val Asn Arg Val Gly  His Asp Tyr Gln Trp  Ile Gly Leu 
    3215                 3220                 3225             


Asn Asp  Lys Met Phe Glu His  Asp Phe Arg Trp Thr  Asp Gly Ser 
    3230                 3235                 3240             


Thr Leu  Gln Tyr Glu Asn Trp  Arg Pro Asn Gln Pro  Asp Ser Phe 
    3245                 3250                 3255             


Phe Ser  Ala Gly Glu Asp Cys  Val Val Ile Ile Trp  His Glu Asn 
    3260                 3265                 3270             


Gly Gln  Trp Asn Asp Val Pro  Cys Asn Tyr His Leu  Thr Tyr Thr 
    3275                 3280                 3285             


Cys Lys  Lys Gly Thr Val Ala  Cys Gly Gln Pro Pro  Val Val Glu 
    3290                 3295                 3300             


Asn Ala  Lys Thr Phe Gly Lys  Met Lys Pro Arg Tyr  Glu Ile Asn 
    3305                 3310                 3315             


Ser Leu  Ile Arg Tyr His Cys  Lys Asp Gly Phe Ile  Gln Arg His 
    3320                 3325                 3330             


Leu Pro  Thr Ile Arg Cys Leu  Gly Asn Gly Arg Trp  Ala Ile Pro 
    3335                 3340                 3345             


Lys Ile  Thr Cys Met Asn Pro  Ser Ala Tyr Gln Arg  Thr Tyr Ser 
    3350                 3355                 3360             


Met Lys  Tyr Phe Lys Asn Ser  Ser Ser Ala Lys Asp  Asn Ser Ile 
    3365                 3370                 3375             


Asn Thr  Ser Lys His Asp His  Arg Trp Ser Arg Arg  Trp Gln Glu 
    3380                 3385                 3390             


Ser Arg  Arg 
    3395     


<210>  701
<211>  2888
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (98)..(2635)

<400>  701
actagctgtc gctccacagg cgagcagggc aggcgtgcgg gcgggtgggt ggtggaggct       60

gcgagggtgc acggccggcc ctgggcaggc ggtagcc atg gag ctg tgg cgc caa       115
                                         Met Glu Leu Trp Arg Gln          
                                         1               5                

tgc acc cac tgg ctc atc cag tgc cgg gtg ctg ccg ccc agc cac cgc        163
Cys Thr His Trp Leu Ile Gln Cys Arg Val Leu Pro Pro Ser His Arg           
            10                  15                  20                    

gtg acc tgg gat ggg gct cag gtg tgt gaa ctg gcc cag gcc ctc cgg        211
Val Thr Trp Asp Gly Ala Gln Val Cys Glu Leu Ala Gln Ala Leu Arg           
        25                  30                  35                        

gat ggt gtc ctt ctg tgt cag ctg ctt aac aac ctg cta ccc cat gcc        259
Asp Gly Val Leu Leu Cys Gln Leu Leu Asn Asn Leu Leu Pro His Ala           
    40                  45                  50                            

atc aac ctg cgt gag gtc aac ctg cgc ccc cag atg tcc cag ttc ctg        307
Ile Asn Leu Arg Glu Val Asn Leu Arg Pro Gln Met Ser Gln Phe Leu           
55                  60                  65                  70            

tgc ctt aag aac att aga acc ttc ctg tcc acc tgc tgt gag aag ttc        355
Cys Leu Lys Asn Ile Arg Thr Phe Leu Ser Thr Cys Cys Glu Lys Phe           
                75                  80                  85                

ggc ctc aag cgg agc gag ctc ttc gaa gcc ttt gac ctc ttc gat gtg        403
Gly Leu Lys Arg Ser Glu Leu Phe Glu Ala Phe Asp Leu Phe Asp Val           
            90                  95                  100                   

cag gat ttt ggc aag gtc atc tac acc ctg tct gct ctg tcc tgg acc        451
Gln Asp Phe Gly Lys Val Ile Tyr Thr Leu Ser Ala Leu Ser Trp Thr           
        105                 110                 115                       

ccg atc gcc cag aac agg ggg atc atg ccc ttc ccc acc gag gag gag        499
Pro Ile Ala Gln Asn Arg Gly Ile Met Pro Phe Pro Thr Glu Glu Glu           
    120                 125                 130                           

agt gta ggt gat gaa gac atc tac agt ggc ctg tcc gac cag atc gac        547
Ser Val Gly Asp Glu Asp Ile Tyr Ser Gly Leu Ser Asp Gln Ile Asp           
135                 140                 145                 150           

gac acg gtg gag gag gat gag gac ctg tat gac tgc gtg gag aat gag        595
Asp Thr Val Glu Glu Asp Glu Asp Leu Tyr Asp Cys Val Glu Asn Glu           
                155                 160                 165               

gag gcg gaa ggc gac gag atc tat gag gac ctc atg cgc tcg gag ccc        643
Glu Ala Glu Gly Asp Glu Ile Tyr Glu Asp Leu Met Arg Ser Glu Pro           
            170                 175                 180                   

gtg tcc atg ccg ccc aag atg aca gag tat gac aag cgc tgc tgc tgc        691
Val Ser Met Pro Pro Lys Met Thr Glu Tyr Asp Lys Arg Cys Cys Cys           
        185                 190                 195                       

ctg cgg gag atc cag cag acg gag gag aag tac act gac acg ctg ggc        739
Leu Arg Glu Ile Gln Gln Thr Glu Glu Lys Tyr Thr Asp Thr Leu Gly           
    200                 205                 210                           

tcc atc cag cag cat ttc ttg aag ccc ctg caa cgg ttc ctg aaa cct        787
Ser Ile Gln Gln His Phe Leu Lys Pro Leu Gln Arg Phe Leu Lys Pro           
215                 220                 225                 230           

caa gac att gag atc atc ttt atc aac att gag gac ctg ctt cgt gtt        835
Gln Asp Ile Glu Ile Ile Phe Ile Asn Ile Glu Asp Leu Leu Arg Val           
                235                 240                 245               

cat act cac ttc cta aag gag atg aag gaa gcc ctg ggc acc cct ggc        883
His Thr His Phe Leu Lys Glu Met Lys Glu Ala Leu Gly Thr Pro Gly           
            250                 255                 260                   

gca gcc aat ctc tac cag gtc ttc atc aaa tac aag gag agg ttc ctc        931
Ala Ala Asn Leu Tyr Gln Val Phe Ile Lys Tyr Lys Glu Arg Phe Leu           
        265                 270                 275                       

gtc tat ggc cgc tac tgc agc cag gtg gag tca gcc agc aaa cac ctg        979
Val Tyr Gly Arg Tyr Cys Ser Gln Val Glu Ser Ala Ser Lys His Leu           
    280                 285                 290                           

gac cgt gtg gcc gca gcc cgg gag gac gtg cag atg aag ctg gag gaa       1027
Asp Arg Val Ala Ala Ala Arg Glu Asp Val Gln Met Lys Leu Glu Glu           
295                 300                 305                 310           

tgt tct cag aga gcc aac aac ggg agg ttc acc ctg cgg gac ctg ctg       1075
Cys Ser Gln Arg Ala Asn Asn Gly Arg Phe Thr Leu Arg Asp Leu Leu           
                315                 320                 325               

atg gtg cct atg cag cga gtt ctc aaa tat cac ctc ctt ctc cag gag       1123
Met Val Pro Met Gln Arg Val Leu Lys Tyr His Leu Leu Leu Gln Glu           
            330                 335                 340                   

ctg gtg aaa cac acg cag gag gcg atg gag aag gag aac ctg cgg ctg       1171
Leu Val Lys His Thr Gln Glu Ala Met Glu Lys Glu Asn Leu Arg Leu           
        345                 350                 355                       

gcc ctg gat gcc atg agg gac ctg gct cag tgc gtg aac gag gtc aag       1219
Ala Leu Asp Ala Met Arg Asp Leu Ala Gln Cys Val Asn Glu Val Lys           
    360                 365                 370                           

cga gac aac gag aca ctg cga cag atc acc aat ttc cag ctg tcc att       1267
Arg Asp Asn Glu Thr Leu Arg Gln Ile Thr Asn Phe Gln Leu Ser Ile           
375                 380                 385                 390           

gag aac ctg gac cag tct ctg gct cac tat ggc cgg ccc aag atc gac       1315
Glu Asn Leu Asp Gln Ser Leu Ala His Tyr Gly Arg Pro Lys Ile Asp           
                395                 400                 405               

ggg gaa ctc aag atc acc tcg gtg gaa cgg cgc tcc aag atg gac agg       1363
Gly Glu Leu Lys Ile Thr Ser Val Glu Arg Arg Ser Lys Met Asp Arg           
            410                 415                 420                   

tat gcc ttc ctg ctc gac aaa gct cta ctc atc tgt aag cgc agg gga       1411
Tyr Ala Phe Leu Leu Asp Lys Ala Leu Leu Ile Cys Lys Arg Arg Gly           
        425                 430                 435                       

gac tcc tat gac ctc aag gac ttt gta aac ctg cac agc ttc cag gtt       1459
Asp Ser Tyr Asp Leu Lys Asp Phe Val Asn Leu His Ser Phe Gln Val           
    440                 445                 450                           

cgg gat gac tct tca gga gac cga gac aac aag aag tgg agc cac atg       1507
Arg Asp Asp Ser Ser Gly Asp Arg Asp Asn Lys Lys Trp Ser His Met           
455                 460                 465                 470           

ttc ctc ctg atc gag gac caa ggt gcc cag ggc tat gag ctg ttc ttc       1555
Phe Leu Leu Ile Glu Asp Gln Gly Ala Gln Gly Tyr Glu Leu Phe Phe           
                475                 480                 485               

aag aca aga gaa ttg aag aag aag tgg atg gag cag ttt gag atg gcc       1603
Lys Thr Arg Glu Leu Lys Lys Lys Trp Met Glu Gln Phe Glu Met Ala           
            490                 495                 500                   

atc tcc aac atc tat ccg gag aat gcc acc gcc aac ggg cat gac ttc       1651
Ile Ser Asn Ile Tyr Pro Glu Asn Ala Thr Ala Asn Gly His Asp Phe           
        505                 510                 515                       

cag atg ttc tcc ttt gag gag acc aca tcc tgc aag gcc tgt cag atg       1699
Gln Met Phe Ser Phe Glu Glu Thr Thr Ser Cys Lys Ala Cys Gln Met           
    520                 525                 530                           

ctg ctt aga ggt acc ttc tat cag ggc tac cgc tgc cat cgg tgc cgg       1747
Leu Leu Arg Gly Thr Phe Tyr Gln Gly Tyr Arg Cys His Arg Cys Arg           
535                 540                 545                 550           

gca tct gca cac aag gag tgt ctg ggg agg gtc cct cca tgt ggc cga       1795
Ala Ser Ala His Lys Glu Cys Leu Gly Arg Val Pro Pro Cys Gly Arg           
                555                 560                 565               

cat ggg caa gat ttc cca gga act atg aag aag gac aaa cta cat cgc       1843
His Gly Gln Asp Phe Pro Gly Thr Met Lys Lys Asp Lys Leu His Arg           
            570                 575                 580                   

agg gct cag gac aaa aag agg aat gag ctg ggt ctg ccc aag atg gag       1891
Arg Ala Gln Asp Lys Lys Arg Asn Glu Leu Gly Leu Pro Lys Met Glu           
        585                 590                 595                       

gtg ttt cag gaa tac tac ggg ctt cct cca ccc cct gga gcc att gga       1939
Val Phe Gln Glu Tyr Tyr Gly Leu Pro Pro Pro Pro Gly Ala Ile Gly           
    600                 605                 610                           

ccc ttt cta cgg ctc aac cct gga gac att gtg gag ctc acg aag gct       1987
Pro Phe Leu Arg Leu Asn Pro Gly Asp Ile Val Glu Leu Thr Lys Ala           
615                 620                 625                 630           

gag gct gaa cag aac tgg tgg gag ggc aga aat aca tct act aat gaa       2035
Glu Ala Glu Gln Asn Trp Trp Glu Gly Arg Asn Thr Ser Thr Asn Glu           
                635                 640                 645               

att ggc tgg ttt cct tgt aac agg gtg aag ccc tat gtc cat ggc cct       2083
Ile Gly Trp Phe Pro Cys Asn Arg Val Lys Pro Tyr Val His Gly Pro           
            650                 655                 660                   

cct cag gac ctg tct gtt cat ctc tgg tac gca ggc ccc atg gag cgg       2131
Pro Gln Asp Leu Ser Val His Leu Trp Tyr Ala Gly Pro Met Glu Arg           
        665                 670                 675                       

gca ggg gca gag agc atc ctg gcc aac cgc tcg gac ggg act ttc ttg       2179
Ala Gly Ala Glu Ser Ile Leu Ala Asn Arg Ser Asp Gly Thr Phe Leu           
    680                 685                 690                           

gtg cgg cag agg gtg aag gat gca gca gaa ttt gcc atc agc att aaa       2227
Val Arg Gln Arg Val Lys Asp Ala Ala Glu Phe Ala Ile Ser Ile Lys           
695                 700                 705                 710           

tat aac gtc gag gtc aag cac att aaa atc atg aca gca gaa gga ctg       2275
Tyr Asn Val Glu Val Lys His Ile Lys Ile Met Thr Ala Glu Gly Leu           
                715                 720                 725               

tac cgg atc aca gag aaa aag gct ttc cgg ggg ctt acg gag ctg gtg       2323
Tyr Arg Ile Thr Glu Lys Lys Ala Phe Arg Gly Leu Thr Glu Leu Val           
            730                 735                 740                   

gag ttt tac cag cag aac tct cta aag gat tgc ttc aag tct ctg gac       2371
Glu Phe Tyr Gln Gln Asn Ser Leu Lys Asp Cys Phe Lys Ser Leu Asp           
        745                 750                 755                       

acc acc ttg cag ttc ccc ttc aag gag cct gaa aag aga acc atc agc       2419
Thr Thr Leu Gln Phe Pro Phe Lys Glu Pro Glu Lys Arg Thr Ile Ser           
    760                 765                 770                           

agg cca gca gtg gga agc aca aag tat ttt ggc aca gcc aaa gcc cgc       2467
Arg Pro Ala Val Gly Ser Thr Lys Tyr Phe Gly Thr Ala Lys Ala Arg           
775                 780                 785                 790           

tat gac ttc tgc gcc cga gac cga tca gag ctg tcg ctc aag gag ggt       2515
Tyr Asp Phe Cys Ala Arg Asp Arg Ser Glu Leu Ser Leu Lys Glu Gly           
                795                 800                 805               

gac atc atc aag atc ctt aac aag aag gga cag caa ggc tgg tgg cga       2563
Asp Ile Ile Lys Ile Leu Asn Lys Lys Gly Gln Gln Gly Trp Trp Arg           
            810                 815                 820                   

ggg gag atc tat ggc cgg gtt ggc tgg ttc cct gcc aac tac gtg gag       2611
Gly Glu Ile Tyr Gly Arg Val Gly Trp Phe Pro Ala Asn Tyr Val Glu           
        825                 830                 835                       

gaa gat tat tct gaa tac tgc tga gccctggtgc cttggcagag agacgagaaa      2665
Glu Asp Tyr Ser Glu Tyr Cys                                               
    840                 845                                               

ctccaggctc tgagcccggc gtgggcaggc agcggagcca ggggctgtga cagctcccgg     2725

cgggtggaga ctttgggatg gactggagga gcgcagcgtc cagctggcgg tgctcccggg     2785

atgtgccctg acatggttaa tttataacac cccgatttcc tcttgggtcc cctcaagcag     2845

acggggctca agggggttac atttaataaa aggatgaaga tgg                       2888


<210>  702
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  702

Met Glu Leu Trp Arg Gln Cys Thr His Trp Leu Ile Gln Cys Arg Val 
1               5                   10                  15      


Leu Pro Pro Ser His Arg Val Thr Trp Asp Gly Ala Gln Val Cys Glu 
            20                  25                  30          


Leu Ala Gln Ala Leu Arg Asp Gly Val Leu Leu Cys Gln Leu Leu Asn 
        35                  40                  45              


Asn Leu Leu Pro His Ala Ile Asn Leu Arg Glu Val Asn Leu Arg Pro 
    50                  55                  60                  


Gln Met Ser Gln Phe Leu Cys Leu Lys Asn Ile Arg Thr Phe Leu Ser 
65                  70                  75                  80  


Thr Cys Cys Glu Lys Phe Gly Leu Lys Arg Ser Glu Leu Phe Glu Ala 
                85                  90                  95      


Phe Asp Leu Phe Asp Val Gln Asp Phe Gly Lys Val Ile Tyr Thr Leu 
            100                 105                 110         


Ser Ala Leu Ser Trp Thr Pro Ile Ala Gln Asn Arg Gly Ile Met Pro 
        115                 120                 125             


Phe Pro Thr Glu Glu Glu Ser Val Gly Asp Glu Asp Ile Tyr Ser Gly 
    130                 135                 140                 


Leu Ser Asp Gln Ile Asp Asp Thr Val Glu Glu Asp Glu Asp Leu Tyr 
145                 150                 155                 160 


Asp Cys Val Glu Asn Glu Glu Ala Glu Gly Asp Glu Ile Tyr Glu Asp 
                165                 170                 175     


Leu Met Arg Ser Glu Pro Val Ser Met Pro Pro Lys Met Thr Glu Tyr 
            180                 185                 190         


Asp Lys Arg Cys Cys Cys Leu Arg Glu Ile Gln Gln Thr Glu Glu Lys 
        195                 200                 205             


Tyr Thr Asp Thr Leu Gly Ser Ile Gln Gln His Phe Leu Lys Pro Leu 
    210                 215                 220                 


Gln Arg Phe Leu Lys Pro Gln Asp Ile Glu Ile Ile Phe Ile Asn Ile 
225                 230                 235                 240 


Glu Asp Leu Leu Arg Val His Thr His Phe Leu Lys Glu Met Lys Glu 
                245                 250                 255     


Ala Leu Gly Thr Pro Gly Ala Ala Asn Leu Tyr Gln Val Phe Ile Lys 
            260                 265                 270         


Tyr Lys Glu Arg Phe Leu Val Tyr Gly Arg Tyr Cys Ser Gln Val Glu 
        275                 280                 285             


Ser Ala Ser Lys His Leu Asp Arg Val Ala Ala Ala Arg Glu Asp Val 
    290                 295                 300                 


Gln Met Lys Leu Glu Glu Cys Ser Gln Arg Ala Asn Asn Gly Arg Phe 
305                 310                 315                 320 


Thr Leu Arg Asp Leu Leu Met Val Pro Met Gln Arg Val Leu Lys Tyr 
                325                 330                 335     


His Leu Leu Leu Gln Glu Leu Val Lys His Thr Gln Glu Ala Met Glu 
            340                 345                 350         


Lys Glu Asn Leu Arg Leu Ala Leu Asp Ala Met Arg Asp Leu Ala Gln 
        355                 360                 365             


Cys Val Asn Glu Val Lys Arg Asp Asn Glu Thr Leu Arg Gln Ile Thr 
    370                 375                 380                 


Asn Phe Gln Leu Ser Ile Glu Asn Leu Asp Gln Ser Leu Ala His Tyr 
385                 390                 395                 400 


Gly Arg Pro Lys Ile Asp Gly Glu Leu Lys Ile Thr Ser Val Glu Arg 
                405                 410                 415     


Arg Ser Lys Met Asp Arg Tyr Ala Phe Leu Leu Asp Lys Ala Leu Leu 
            420                 425                 430         


Ile Cys Lys Arg Arg Gly Asp Ser Tyr Asp Leu Lys Asp Phe Val Asn 
        435                 440                 445             


Leu His Ser Phe Gln Val Arg Asp Asp Ser Ser Gly Asp Arg Asp Asn 
    450                 455                 460                 


Lys Lys Trp Ser His Met Phe Leu Leu Ile Glu Asp Gln Gly Ala Gln 
465                 470                 475                 480 


Gly Tyr Glu Leu Phe Phe Lys Thr Arg Glu Leu Lys Lys Lys Trp Met 
                485                 490                 495     


Glu Gln Phe Glu Met Ala Ile Ser Asn Ile Tyr Pro Glu Asn Ala Thr 
            500                 505                 510         


Ala Asn Gly His Asp Phe Gln Met Phe Ser Phe Glu Glu Thr Thr Ser 
        515                 520                 525             


Cys Lys Ala Cys Gln Met Leu Leu Arg Gly Thr Phe Tyr Gln Gly Tyr 
    530                 535                 540                 


Arg Cys His Arg Cys Arg Ala Ser Ala His Lys Glu Cys Leu Gly Arg 
545                 550                 555                 560 


Val Pro Pro Cys Gly Arg His Gly Gln Asp Phe Pro Gly Thr Met Lys 
                565                 570                 575     


Lys Asp Lys Leu His Arg Arg Ala Gln Asp Lys Lys Arg Asn Glu Leu 
            580                 585                 590         


Gly Leu Pro Lys Met Glu Val Phe Gln Glu Tyr Tyr Gly Leu Pro Pro 
        595                 600                 605             


Pro Pro Gly Ala Ile Gly Pro Phe Leu Arg Leu Asn Pro Gly Asp Ile 
    610                 615                 620                 


Val Glu Leu Thr Lys Ala Glu Ala Glu Gln Asn Trp Trp Glu Gly Arg 
625                 630                 635                 640 


Asn Thr Ser Thr Asn Glu Ile Gly Trp Phe Pro Cys Asn Arg Val Lys 
                645                 650                 655     


Pro Tyr Val His Gly Pro Pro Gln Asp Leu Ser Val His Leu Trp Tyr 
            660                 665                 670         


Ala Gly Pro Met Glu Arg Ala Gly Ala Glu Ser Ile Leu Ala Asn Arg 
        675                 680                 685             


Ser Asp Gly Thr Phe Leu Val Arg Gln Arg Val Lys Asp Ala Ala Glu 
    690                 695                 700                 


Phe Ala Ile Ser Ile Lys Tyr Asn Val Glu Val Lys His Ile Lys Ile 
705                 710                 715                 720 


Met Thr Ala Glu Gly Leu Tyr Arg Ile Thr Glu Lys Lys Ala Phe Arg 
                725                 730                 735     


Gly Leu Thr Glu Leu Val Glu Phe Tyr Gln Gln Asn Ser Leu Lys Asp 
            740                 745                 750         


Cys Phe Lys Ser Leu Asp Thr Thr Leu Gln Phe Pro Phe Lys Glu Pro 
        755                 760                 765             


Glu Lys Arg Thr Ile Ser Arg Pro Ala Val Gly Ser Thr Lys Tyr Phe 
    770                 775                 780                 


Gly Thr Ala Lys Ala Arg Tyr Asp Phe Cys Ala Arg Asp Arg Ser Glu 
785                 790                 795                 800 


Leu Ser Leu Lys Glu Gly Asp Ile Ile Lys Ile Leu Asn Lys Lys Gly 
                805                 810                 815     


Gln Gln Gly Trp Trp Arg Gly Glu Ile Tyr Gly Arg Val Gly Trp Phe 
            820                 825                 830         


Pro Ala Asn Tyr Val Glu Glu Asp Tyr Ser Glu Tyr Cys 
        835                 840                 845 


<210>  703
<211>  2509
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (29)..(2344)

<400>  703
gtccatgtga gagaagctgg ctgctgaa atg act gcg aac cgg ctt gca gag          52
                               Met Thr Ala Asn Arg Leu Ala Glu            
                               1               5                          

agc ctt ctg gct ttg agc caa cag gaa gaa cta gcg gat ttg cca aaa        100
Ser Leu Leu Ala Leu Ser Gln Gln Glu Glu Leu Ala Asp Leu Pro Lys           
    10                  15                  20                            

gac tac ctc ttg agt gag agt gaa gat gag ggg gac aat gat gga gag        148
Asp Tyr Leu Leu Ser Glu Ser Glu Asp Glu Gly Asp Asn Asp Gly Glu           
25                  30                  35                  40            

aga aag cat caa aag ctt ctg gaa gca atc agt tcc ctt gat gga aag        196
Arg Lys His Gln Lys Leu Leu Glu Ala Ile Ser Ser Leu Asp Gly Lys           
                45                  50                  55                

aat agg cgg aaa ttg gct gag agg tct gag gct agt ctg aag gtg tca        244
Asn Arg Arg Lys Leu Ala Glu Arg Ser Glu Ala Ser Leu Lys Val Ser           
            60                  65                  70                    

gag ttc aat gtc agt tct gaa gga tca gga gaa aag ctg gtc ctt gca        292
Glu Phe Asn Val Ser Ser Glu Gly Ser Gly Glu Lys Leu Val Leu Ala           
        75                  80                  85                        

gat ctg ctt gag cct gtt aaa act tca tct tct ttg gcc act gtg aaa        340
Asp Leu Leu Glu Pro Val Lys Thr Ser Ser Ser Leu Ala Thr Val Lys           
    90                  95                  100                           

aag caa ctg agt aga gtc aaa tca aag aag aca gtg gag tta cct ctg        388
Lys Gln Leu Ser Arg Val Lys Ser Lys Lys Thr Val Glu Leu Pro Leu           
105                 110                 115                 120           

aac aaa gaa gag att gaa cgg atc cac aga gaa gta gca ttc aat aaa        436
Asn Lys Glu Glu Ile Glu Arg Ile His Arg Glu Val Ala Phe Asn Lys           
                125                 130                 135               

acc gca caa gtc ctc tcc aaa tgg gac cct gtc gtc ctg aag aac cgg        484
Thr Ala Gln Val Leu Ser Lys Trp Asp Pro Val Val Leu Lys Asn Arg           
            140                 145                 150                   

cag gca gag cag ctg gtt ttt ccc ctg gag aaa gag gag cca gcc att        532
Gln Ala Glu Gln Leu Val Phe Pro Leu Glu Lys Glu Glu Pro Ala Ile           
        155                 160                 165                       

gct ccc att gaa cat gtg ctc agt ggc tgg aag gca aga act ccc ctg        580
Ala Pro Ile Glu His Val Leu Ser Gly Trp Lys Ala Arg Thr Pro Leu           
    170                 175                 180                           

gag cag gaa att ttc aac ctc ctc cat aag aac aag cag cca gtg aca        628
Glu Gln Glu Ile Phe Asn Leu Leu His Lys Asn Lys Gln Pro Val Thr           
185                 190                 195                 200           

gac cct tta ctg acc cct gtg gaa aag gcc tct ctc cga gcc atg agc        676
Asp Pro Leu Leu Thr Pro Val Glu Lys Ala Ser Leu Arg Ala Met Ser           
                205                 210                 215               

cta gaa gag gca aag atg cga cga gca gag ctt cag agg gct cgg gct        724
Leu Glu Glu Ala Lys Met Arg Arg Ala Glu Leu Gln Arg Ala Arg Ala           
            220                 225                 230                   

ctg cag tcc tac tat gag gcc aag gct cga aga gag aag aaa atc aaa        772
Leu Gln Ser Tyr Tyr Glu Ala Lys Ala Arg Arg Glu Lys Lys Ile Lys           
        235                 240                 245                       

agt aaa aag tat cac aaa gtc gtg aag aaa gga aag gcc aag aaa gcc        820
Ser Lys Lys Tyr His Lys Val Val Lys Lys Gly Lys Ala Lys Lys Ala           
    250                 255                 260                           

cta aaa gag ttt gag cag ctg cgg aag gtt aat cca gct gca gca cta        868
Leu Lys Glu Phe Glu Gln Leu Arg Lys Val Asn Pro Ala Ala Ala Leu           
265                 270                 275                 280           

gaa gaa ctg gaa aaa att gaa aag gcc aga atg atg gaa aga atg agc        916
Glu Glu Leu Glu Lys Ile Glu Lys Ala Arg Met Met Glu Arg Met Ser           
                285                 290                 295               

ctt aag cac caa aac agt ggg aaa tgg gcc aag tca aag gca att atg        964
Leu Lys His Gln Asn Ser Gly Lys Trp Ala Lys Ser Lys Ala Ile Met           
            300                 305                 310                   

gcc aaa tat gac ctg gag gct cgc caa gct atg cag gaa cag ttg tct       1012
Ala Lys Tyr Asp Leu Glu Ala Arg Gln Ala Met Gln Glu Gln Leu Ser           
        315                 320                 325                       

aag aac aaa gaa ctg aca cag aaa ctc cag gta gcc tct gag agt gag       1060
Lys Asn Lys Glu Leu Thr Gln Lys Leu Gln Val Ala Ser Glu Ser Glu           
    330                 335                 340                           

gaa gag gag gga ggc aca gaa gat gtg gaa gaa ctc ctt gtc cct gat       1108
Glu Glu Glu Gly Gly Thr Glu Asp Val Glu Glu Leu Leu Val Pro Asp           
345                 350                 355                 360           

gta gtg aat gaa gtg cag atg aat gca gat ggg ccg aat ccc tgg atg       1156
Val Val Asn Glu Val Gln Met Asn Ala Asp Gly Pro Asn Pro Trp Met           
                365                 370                 375               

ctc agg agc tgc acc agt gac acc aaa gag gct gca acc cag gag gac       1204
Leu Arg Ser Cys Thr Ser Asp Thr Lys Glu Ala Ala Thr Gln Glu Asp           
            380                 385                 390                   

cct gag caa ctg cca gag ctt gag gcc cat gga gtt tct gaa agt gag       1252
Pro Glu Gln Leu Pro Glu Leu Glu Ala His Gly Val Ser Glu Ser Glu           
        395                 400                 405                       

gga gaa gaa aga cca gtg gca gaa gaa gaa att ttg ttg aga gaa ttt       1300
Gly Glu Glu Arg Pro Val Ala Glu Glu Glu Ile Leu Leu Arg Glu Phe           
    410                 415                 420                           

gag gaa agg cga tcc ctt aga aaa aga tct gag ctc agc caa gat gct       1348
Glu Glu Arg Arg Ser Leu Arg Lys Arg Ser Glu Leu Ser Gln Asp Ala           
425                 430                 435                 440           

gag cca gca ggc agt caa gaa aca aaa gat tct ggc agc cag gag gtg       1396
Glu Pro Ala Gly Ser Gln Glu Thr Lys Asp Ser Gly Ser Gln Glu Val           
                445                 450                 455               

ctg tct gaa ttg aga gta cta tct cag aaa ttg aag gaa aac cat cag       1444
Leu Ser Glu Leu Arg Val Leu Ser Gln Lys Leu Lys Glu Asn His Gln           
            460                 465                 470                   

tcc agg aag caa aaa gca agt tca gag ggg act att ccc cag gtc cag       1492
Ser Arg Lys Gln Lys Ala Ser Ser Glu Gly Thr Ile Pro Gln Val Gln           
        475                 480                 485                       

aga gag gaa cct gcc cca gaa gaa gag gag ccc ctg ttg cta cag aga       1540
Arg Glu Glu Pro Ala Pro Glu Glu Glu Glu Pro Leu Leu Leu Gln Arg           
    490                 495                 500                           

cca gag aga gta cag acg ctg gaa gag cta gaa gag ctg gga aaa gaa       1588
Pro Glu Arg Val Gln Thr Leu Glu Glu Leu Glu Glu Leu Gly Lys Glu           
505                 510                 515                 520           

gaa tgt ttt caa aat aag gag ctt ccc aga cct gtg tta gaa ggg cag       1636
Glu Cys Phe Gln Asn Lys Glu Leu Pro Arg Pro Val Leu Glu Gly Gln           
                525                 530                 535               

cag tca gag agg acc cca aat aat cgc cct gat gcc cct aag gag aag       1684
Gln Ser Glu Arg Thr Pro Asn Asn Arg Pro Asp Ala Pro Lys Glu Lys           
            540                 545                 550                   

aaa aag aag gag caa atg atc gac cta cag aac ctc cta acc aca caa       1732
Lys Lys Lys Glu Gln Met Ile Asp Leu Gln Asn Leu Leu Thr Thr Gln           
        555                 560                 565                       

tct ccc tcc gtg aag tct ttg gca gtt ccc aca ata gag gag ctg gaa       1780
Ser Pro Ser Val Lys Ser Leu Ala Val Pro Thr Ile Glu Glu Leu Glu           
    570                 575                 580                           

gat gaa gag gag aga aac cat agg cag atg ata aag gaa gct ttt gct       1828
Asp Glu Glu Glu Arg Asn His Arg Gln Met Ile Lys Glu Ala Phe Ala           
585                 590                 595                 600           

ggg gat gat gtc atc aga gat ttc ttg aaa gag aag agg gaa gct gtg       1876
Gly Asp Asp Val Ile Arg Asp Phe Leu Lys Glu Lys Arg Glu Ala Val           
                605                 610                 615               

gag gcg agt aag cca aag gac gtg gac ctg aca cta cct ggc tgg ggc       1924
Glu Ala Ser Lys Pro Lys Asp Val Asp Leu Thr Leu Pro Gly Trp Gly           
            620                 625                 630                   

gag tgg ggt ggt gtg ggc cta aag ccc agt gcc aag aaa aga cgc cgg       1972
Glu Trp Gly Gly Val Gly Leu Lys Pro Ser Ala Lys Lys Arg Arg Arg           
        635                 640                 645                       

ttt ctc att aaa gcc cct gag ggt cct cca aga aaa gat aag aat ttg       2020
Phe Leu Ile Lys Ala Pro Glu Gly Pro Pro Arg Lys Asp Lys Asn Leu           
    650                 655                 660                           

cca aat gtg att atc aat gag aag cgc aac atc cac gca gct gct cat       2068
Pro Asn Val Ile Ile Asn Glu Lys Arg Asn Ile His Ala Ala Ala His           
665                 670                 675                 680           

cag gta cga gtg ctt cca tat cca ttt acc cac cat tgg caa ttt gaa       2116
Gln Val Arg Val Leu Pro Tyr Pro Phe Thr His His Trp Gln Phe Glu           
                685                 690                 695               

agg acc atc cag acc ccc ata gga tcc aca tgg aac acc cag agg gct       2164
Arg Thr Ile Gln Thr Pro Ile Gly Ser Thr Trp Asn Thr Gln Arg Ala           
            700                 705                 710                   

ttc caa aag ctg act act ccc aag gtc gtc acc aag cca ggc cat atc       2212
Phe Gln Lys Leu Thr Thr Pro Lys Val Val Thr Lys Pro Gly His Ile           
        715                 720                 725                       

att aac ccc ata aaa gca gaa gac gtg ggc tac cgg tct tcc tca agg       2260
Ile Asn Pro Ile Lys Ala Glu Asp Val Gly Tyr Arg Ser Ser Ser Arg           
    730                 735                 740                           

tcg gac ctg tct gtc ata cag agg aat cca aaa cga atc acc aca cgt       2308
Ser Asp Leu Ser Val Ile Gln Arg Asn Pro Lys Arg Ile Thr Thr Arg           
745                 750                 755                 760           

cac aaa aaa cag ctg aag aaa tgc tct gta gat tga gttgctggag            2354
His Lys Lys Gln Leu Lys Lys Cys Ser Val Asp                               
                765                 770                                   

gagtgacagc caggagccct gacttcactt cctttggtcc agttttactc tgatacaggg     2414

tggattccaa aactggctca gtacattgca tgtagttaag ccacatttta aaaataaagg     2474

cattttttaa tctaaaaaaa aaaaaaaaaa aaaaa                                2509


<210>  704
<211>  771
<212>  PRT
<213>  Homo sapiens

<400>  704

Met Thr Ala Asn Arg Leu Ala Glu Ser Leu Leu Ala Leu Ser Gln Gln 
1               5                   10                  15      


Glu Glu Leu Ala Asp Leu Pro Lys Asp Tyr Leu Leu Ser Glu Ser Glu 
            20                  25                  30          


Asp Glu Gly Asp Asn Asp Gly Glu Arg Lys His Gln Lys Leu Leu Glu 
        35                  40                  45              


Ala Ile Ser Ser Leu Asp Gly Lys Asn Arg Arg Lys Leu Ala Glu Arg 
    50                  55                  60                  


Ser Glu Ala Ser Leu Lys Val Ser Glu Phe Asn Val Ser Ser Glu Gly 
65                  70                  75                  80  


Ser Gly Glu Lys Leu Val Leu Ala Asp Leu Leu Glu Pro Val Lys Thr 
                85                  90                  95      


Ser Ser Ser Leu Ala Thr Val Lys Lys Gln Leu Ser Arg Val Lys Ser 
            100                 105                 110         


Lys Lys Thr Val Glu Leu Pro Leu Asn Lys Glu Glu Ile Glu Arg Ile 
        115                 120                 125             


His Arg Glu Val Ala Phe Asn Lys Thr Ala Gln Val Leu Ser Lys Trp 
    130                 135                 140                 


Asp Pro Val Val Leu Lys Asn Arg Gln Ala Glu Gln Leu Val Phe Pro 
145                 150                 155                 160 


Leu Glu Lys Glu Glu Pro Ala Ile Ala Pro Ile Glu His Val Leu Ser 
                165                 170                 175     


Gly Trp Lys Ala Arg Thr Pro Leu Glu Gln Glu Ile Phe Asn Leu Leu 
            180                 185                 190         


His Lys Asn Lys Gln Pro Val Thr Asp Pro Leu Leu Thr Pro Val Glu 
        195                 200                 205             


Lys Ala Ser Leu Arg Ala Met Ser Leu Glu Glu Ala Lys Met Arg Arg 
    210                 215                 220                 


Ala Glu Leu Gln Arg Ala Arg Ala Leu Gln Ser Tyr Tyr Glu Ala Lys 
225                 230                 235                 240 


Ala Arg Arg Glu Lys Lys Ile Lys Ser Lys Lys Tyr His Lys Val Val 
                245                 250                 255     


Lys Lys Gly Lys Ala Lys Lys Ala Leu Lys Glu Phe Glu Gln Leu Arg 
            260                 265                 270         


Lys Val Asn Pro Ala Ala Ala Leu Glu Glu Leu Glu Lys Ile Glu Lys 
        275                 280                 285             


Ala Arg Met Met Glu Arg Met Ser Leu Lys His Gln Asn Ser Gly Lys 
    290                 295                 300                 


Trp Ala Lys Ser Lys Ala Ile Met Ala Lys Tyr Asp Leu Glu Ala Arg 
305                 310                 315                 320 


Gln Ala Met Gln Glu Gln Leu Ser Lys Asn Lys Glu Leu Thr Gln Lys 
                325                 330                 335     


Leu Gln Val Ala Ser Glu Ser Glu Glu Glu Glu Gly Gly Thr Glu Asp 
            340                 345                 350         


Val Glu Glu Leu Leu Val Pro Asp Val Val Asn Glu Val Gln Met Asn 
        355                 360                 365             


Ala Asp Gly Pro Asn Pro Trp Met Leu Arg Ser Cys Thr Ser Asp Thr 
    370                 375                 380                 


Lys Glu Ala Ala Thr Gln Glu Asp Pro Glu Gln Leu Pro Glu Leu Glu 
385                 390                 395                 400 


Ala His Gly Val Ser Glu Ser Glu Gly Glu Glu Arg Pro Val Ala Glu 
                405                 410                 415     


Glu Glu Ile Leu Leu Arg Glu Phe Glu Glu Arg Arg Ser Leu Arg Lys 
            420                 425                 430         


Arg Ser Glu Leu Ser Gln Asp Ala Glu Pro Ala Gly Ser Gln Glu Thr 
        435                 440                 445             


Lys Asp Ser Gly Ser Gln Glu Val Leu Ser Glu Leu Arg Val Leu Ser 
    450                 455                 460                 


Gln Lys Leu Lys Glu Asn His Gln Ser Arg Lys Gln Lys Ala Ser Ser 
465                 470                 475                 480 


Glu Gly Thr Ile Pro Gln Val Gln Arg Glu Glu Pro Ala Pro Glu Glu 
                485                 490                 495     


Glu Glu Pro Leu Leu Leu Gln Arg Pro Glu Arg Val Gln Thr Leu Glu 
            500                 505                 510         


Glu Leu Glu Glu Leu Gly Lys Glu Glu Cys Phe Gln Asn Lys Glu Leu 
        515                 520                 525             


Pro Arg Pro Val Leu Glu Gly Gln Gln Ser Glu Arg Thr Pro Asn Asn 
    530                 535                 540                 


Arg Pro Asp Ala Pro Lys Glu Lys Lys Lys Lys Glu Gln Met Ile Asp 
545                 550                 555                 560 


Leu Gln Asn Leu Leu Thr Thr Gln Ser Pro Ser Val Lys Ser Leu Ala 
                565                 570                 575     


Val Pro Thr Ile Glu Glu Leu Glu Asp Glu Glu Glu Arg Asn His Arg 
            580                 585                 590         


Gln Met Ile Lys Glu Ala Phe Ala Gly Asp Asp Val Ile Arg Asp Phe 
        595                 600                 605             


Leu Lys Glu Lys Arg Glu Ala Val Glu Ala Ser Lys Pro Lys Asp Val 
    610                 615                 620                 


Asp Leu Thr Leu Pro Gly Trp Gly Glu Trp Gly Gly Val Gly Leu Lys 
625                 630                 635                 640 


Pro Ser Ala Lys Lys Arg Arg Arg Phe Leu Ile Lys Ala Pro Glu Gly 
                645                 650                 655     


Pro Pro Arg Lys Asp Lys Asn Leu Pro Asn Val Ile Ile Asn Glu Lys 
            660                 665                 670         


Arg Asn Ile His Ala Ala Ala His Gln Val Arg Val Leu Pro Tyr Pro 
        675                 680                 685             


Phe Thr His His Trp Gln Phe Glu Arg Thr Ile Gln Thr Pro Ile Gly 
    690                 695                 700                 


Ser Thr Trp Asn Thr Gln Arg Ala Phe Gln Lys Leu Thr Thr Pro Lys 
705                 710                 715                 720 


Val Val Thr Lys Pro Gly His Ile Ile Asn Pro Ile Lys Ala Glu Asp 
                725                 730                 735     


Val Gly Tyr Arg Ser Ser Ser Arg Ser Asp Leu Ser Val Ile Gln Arg 
            740                 745                 750         


Asn Pro Lys Arg Ile Thr Thr Arg His Lys Lys Gln Leu Lys Lys Cys 
        755                 760                 765             


Ser Val Asp 
    770     


<210>  705
<211>  645
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(645)

<400>  705
atg aga tgt gtg gca gct gag acc cgg gaa ctg ctc aag ggc acc agg         48
Met Arg Cys Val Ala Ala Glu Thr Arg Glu Leu Leu Lys Gly Thr Arg           
1               5                   10                  15                

ccc cat ctg tct gca ctc act cac ctt cct cag agc ttt tcg ggg agc         96
Pro His Leu Ser Ala Leu Thr His Leu Pro Gln Ser Phe Ser Gly Ser           
            20                  25                  30                    

aac ttg gca agg ggg ggt ccc agc agc tgc tcg cgg gcc agg aac cat        144
Asn Leu Ala Arg Gly Gly Pro Ser Ser Cys Ser Arg Ala Arg Asn His           
        35                  40                  45                        

ggg gca cag ccc cgg gcg acc ctc ggg ccg gcg ggg gcc ttc cgc ttc        192
Gly Ala Gln Pro Arg Ala Thr Leu Gly Pro Ala Gly Ala Phe Arg Phe           
    50                  55                  60                            

ctg gcg tct ttc ttc ccc gcc ccg ccg gct gct ggg gaa gcg gcg ggc        240
Leu Ala Ser Phe Phe Pro Ala Pro Pro Ala Ala Gly Glu Ala Ala Gly           
65                  70                  75                  80            

gcc cag tgc ctg gag gtc gct ccc tcg cct cct ctg gct gcg gga acg        288
Ala Gln Cys Leu Glu Val Ala Pro Ser Pro Pro Leu Ala Ala Gly Thr           
                85                  90                  95                

gag agg cgg cgg cgg ccg gag cag ggt ggg cgg cct gag ccg aga gcc        336
Glu Arg Arg Arg Arg Pro Glu Gln Gly Gly Arg Pro Glu Pro Arg Ala           
            100                 105                 110                   

cgg ccg gcc ccc gcg agg aat atg gcg acc tgc ggc gac cgg agc agc        384
Arg Pro Ala Pro Ala Arg Asn Met Ala Thr Cys Gly Asp Arg Ser Ser           
        115                 120                 125                       

agc ggc gtc agt tgc tgc acc gcc gac ttc ttg gag cag cga aag cga        432
Ser Gly Val Ser Cys Cys Thr Ala Asp Phe Leu Glu Gln Arg Lys Arg           
    130                 135                 140                           

ctc gcg aga aga cgc cgc caa gtg gaa ccc ggg ccc tgc ggc cct ggg        480
Leu Ala Arg Arg Arg Arg Gln Val Glu Pro Gly Pro Cys Gly Pro Gly           
145                 150                 155                 160           

agg ggg cag cag cga cac agc cat gaa gcc ccg ggc gcg gcg ctg ggc        528
Arg Gly Gln Gln Arg His Ser His Glu Ala Pro Gly Ala Ala Leu Gly           
                165                 170                 175               

gcc aac gag agc cac ggc aac ctc cag acg gcg cca cag caa cct cta        576
Ala Asn Glu Ser His Gly Asn Leu Gln Thr Ala Pro Gln Gln Pro Leu           
            180                 185                 190                   

ggc agt gcc cac acc agc cta cag gtg gcg ccc ctc gca ctg cac ctg        624
Gly Ser Ala His Thr Ser Leu Gln Val Ala Pro Leu Ala Leu His Leu           
        195                 200                 205                       

ccg cgg ccg ccc cgg gtg tga                                            645
Pro Arg Pro Pro Arg Val                                                   
    210                                                                   


<210>  706
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  706

Met Arg Cys Val Ala Ala Glu Thr Arg Glu Leu Leu Lys Gly Thr Arg 
1               5                   10                  15      


Pro His Leu Ser Ala Leu Thr His Leu Pro Gln Ser Phe Ser Gly Ser 
            20                  25                  30          


Asn Leu Ala Arg Gly Gly Pro Ser Ser Cys Ser Arg Ala Arg Asn His 
        35                  40                  45              


Gly Ala Gln Pro Arg Ala Thr Leu Gly Pro Ala Gly Ala Phe Arg Phe 
    50                  55                  60                  


Leu Ala Ser Phe Phe Pro Ala Pro Pro Ala Ala Gly Glu Ala Ala Gly 
65                  70                  75                  80  


Ala Gln Cys Leu Glu Val Ala Pro Ser Pro Pro Leu Ala Ala Gly Thr 
                85                  90                  95      


Glu Arg Arg Arg Arg Pro Glu Gln Gly Gly Arg Pro Glu Pro Arg Ala 
            100                 105                 110         


Arg Pro Ala Pro Ala Arg Asn Met Ala Thr Cys Gly Asp Arg Ser Ser 
        115                 120                 125             


Ser Gly Val Ser Cys Cys Thr Ala Asp Phe Leu Glu Gln Arg Lys Arg 
    130                 135                 140                 


Leu Ala Arg Arg Arg Arg Gln Val Glu Pro Gly Pro Cys Gly Pro Gly 
145                 150                 155                 160 


Arg Gly Gln Gln Arg His Ser His Glu Ala Pro Gly Ala Ala Leu Gly 
                165                 170                 175     


Ala Asn Glu Ser His Gly Asn Leu Gln Thr Ala Pro Gln Gln Pro Leu 
            180                 185                 190         


Gly Ser Ala His Thr Ser Leu Gln Val Ala Pro Leu Ala Leu His Leu 
        195                 200                 205             


Pro Arg Pro Pro Arg Val 
    210                 


<210>  707
<211>  2118
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (39)..(1247)

<400>  707
agcaggaggg tgggaccaag ggtgctgctg gaccaagg atg gga ctg ggc caa ggg       56
                                          Met Gly Leu Gly Gln Gly         
                                          1               5               

tgg ggc tgg gaa gca tcc tgt ttt gca tgt ttg atc agg agc tgc tgc        104
Trp Gly Trp Glu Ala Ser Cys Phe Ala Cys Leu Ile Arg Ser Cys Cys           
            10                  15                  20                    

caa gtt gtg act ttc act ttc cct ttt ggg ttc cag ggt ata tct cag        152
Gln Val Val Thr Phe Thr Phe Pro Phe Gly Phe Gln Gly Ile Ser Gln           
        25                  30                  35                        

agc ctg gag aac gtg tct ggt tat tat gca gat gca cgg ctg gag gtg        200
Ser Leu Glu Asn Val Ser Gly Tyr Tyr Ala Asp Ala Arg Leu Glu Val           
    40                  45                  50                            

gga tcc aca cag ctc aga aca gct gga tct tgc tca cac tct ttc aag        248
Gly Ser Thr Gln Leu Arg Thr Ala Gly Ser Cys Ser His Ser Phe Lys           
55                  60                  65                  70            

aga agc ttc ctt gaa aag aaa cgc ttt act gaa gag gcc acc aaa tac        296
Arg Ser Phe Leu Glu Lys Lys Arg Phe Thr Glu Glu Ala Thr Lys Tyr           
                75                  80                  85                

ttc cgg gag aga gtc agc cca gtg cat ctg caa atc ctg ctg act aac        344
Phe Arg Glu Arg Val Ser Pro Val His Leu Gln Ile Leu Leu Thr Asn           
            90                  95                  100                   

aat gaa gcc tgg aag aga ttc gtg act gcg gct gaa ttg ccc agg gat        392
Asn Glu Ala Trp Lys Arg Phe Val Thr Ala Ala Glu Leu Pro Arg Asp           
        105                 110                 115                       

gag gca gat gct ctc tac gaa gct ctg aag aag ctt aga aca tat gca        440
Glu Ala Asp Ala Leu Tyr Glu Ala Leu Lys Lys Leu Arg Thr Tyr Ala           
    120                 125                 130                           

gct att gag gac gaa tat gtg cag cag aaa gat gag cag ttt agg gaa        488
Ala Ile Glu Asp Glu Tyr Val Gln Gln Lys Asp Glu Gln Phe Arg Glu           
135                 140                 145                 150           

tgg ttt ttg aaa gag ttt ccc caa gtc aag agg aag atc cag gag tcc        536
Trp Phe Leu Lys Glu Phe Pro Gln Val Lys Arg Lys Ile Gln Glu Ser           
                155                 160                 165               

ata gaa aag ctt cgt gcc ctt gca aat ggt att gaa gag gtc cac aga        584
Ile Glu Lys Leu Arg Ala Leu Ala Asn Gly Ile Glu Glu Val His Arg           
            170                 175                 180                   

ggc tgc acc atc tcc aat gtg gtg tcc agc tcc act ggc gct gcc tct        632
Gly Cys Thr Ile Ser Asn Val Val Ser Ser Ser Thr Gly Ala Ala Ser           
        185                 190                 195                       

ggc atc atg tcc ctt gct ggt ctt gtt ttg gca cca ttt aca gca ggg        680
Gly Ile Met Ser Leu Ala Gly Leu Val Leu Ala Pro Phe Thr Ala Gly           
    200                 205                 210                           

acg agt ctg gcc ctt act gca gct ggg gta ggg ctg gga gca gcg tct        728
Thr Ser Leu Ala Leu Thr Ala Ala Gly Val Gly Leu Gly Ala Ala Ser           
215                 220                 225                 230           

gct gtg act ggg atc acc acc agc atc gtg gag cac tca tac aca tca        776
Ala Val Thr Gly Ile Thr Thr Ser Ile Val Glu His Ser Tyr Thr Ser           
                235                 240                 245               

tca gca gaa gct gaa gcc agc agg ctg act gca acc agc att gac cga        824
Ser Ala Glu Ala Glu Ala Ser Arg Leu Thr Ala Thr Ser Ile Asp Arg           
            250                 255                 260                   

ttg aag gta ttt aag gaa gtt atg cgt gac atc aca ccc aac tta ctt        872
Leu Lys Val Phe Lys Glu Val Met Arg Asp Ile Thr Pro Asn Leu Leu           
        265                 270                 275                       

tcc ctt ctt aat aat tat tac gaa gcc aca caa acc att ggg agt gaa        920
Ser Leu Leu Asn Asn Tyr Tyr Glu Ala Thr Gln Thr Ile Gly Ser Glu           
    280                 285                 290                           

atc cgt gcc atc agg caa gcc aga gcc agg gcc cga ctc cct gtg acc        968
Ile Arg Ala Ile Arg Gln Ala Arg Ala Arg Ala Arg Leu Pro Val Thr           
295                 300                 305                 310           

acc tgg cga atc tca gct gga agt ggt ggt caa gca gag aga acg att       1016
Thr Trp Arg Ile Ser Ala Gly Ser Gly Gly Gln Ala Glu Arg Thr Ile           
                315                 320                 325               

gca ggc acc acc cgg gca gtg agc aga gga gcc cgg atc ctg agt gcg       1064
Ala Gly Thr Thr Arg Ala Val Ser Arg Gly Ala Arg Ile Leu Ser Ala           
            330                 335                 340                   

acc act tca ggc atc ttc ctt gca ctg gat gtg gtc aac ctt gta tac       1112
Thr Thr Ser Gly Ile Phe Leu Ala Leu Asp Val Val Asn Leu Val Tyr           
        345                 350                 355                       

gag tca aag cac ttg cat gag ggg gca aag tct gca tct gct gag gag       1160
Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Ala Ser Ala Glu Glu           
    360                 365                 370                           

ctg agg cgg cag gct cag gag ctg gag gag aat cta atg gag ctc act       1208
Leu Arg Arg Gln Ala Gln Glu Leu Glu Glu Asn Leu Met Glu Leu Thr           
375                 380                 385                 390           

cag atc tat cag cgt ctg aat cca tgc cat acc cac tga ccccagacca        1257
Gln Ile Tyr Gln Arg Leu Asn Pro Cys His Thr His                           
                395                 400                                   

gtgcagccag caggggaggt gagccataca caggccacga caaaatgcag gcattttatt     1317

agggggataa agagggcaag gtaaagttta tggagctgag tgttagtgac tttggcattt     1377

ctgtagctga gcacagcagg ggaggggtta atgcagatgg caagtgcacc aaggagaagg     1437

caggaatgct ggagcctgga ataagggagg agaggggact ggagagtgtg gggaatagga     1497

agaagaaatt tcctttagac taacgaatat attgggggga ggaatagagg ggaggtgtgc     1557

aggaaccagc aatgagaagg ccaggaaaag aaagagctga aaatgcagaa agccgaagag     1617

ttagaacttt tggatacagc agaagaaaca gcggctccac taccgacctg cccccggttc     1677

gatgtccttc caagaatgaa gtctttccct ggtgatggtc ccctgccctg tctttccagc     1737

atccactctg tcttgtcctc ctggaagtgt atctcagtca gccagtggct tcttgatgat     1797

ggcggtggag gtggtggttg tagtgtgatg gatccccttt aggttattta ggggtatatg     1857

tcccctgctt gaaccctgaa ggccaggtaa tgagccatgg ccattgtccc cagctgagga     1917

ccaggtgtct ctaaaaaccc aaacatcctg gagagtatgc gagaacctac caagaaaaac     1977

agtctcatta ctcatataca gcaggcaaag agacagaaaa ttaactgaaa agcagtttag     2037

agactggggg aggccggatc tctagagcca tcctgctgag tgccctgtgt gtaagtccta     2097

ataaactcac ctactcacca a                                               2118


<210>  708
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  708

Met Gly Leu Gly Gln Gly Trp Gly Trp Glu Ala Ser Cys Phe Ala Cys 
1               5                   10                  15      


Leu Ile Arg Ser Cys Cys Gln Val Val Thr Phe Thr Phe Pro Phe Gly 
            20                  25                  30          


Phe Gln Gly Ile Ser Gln Ser Leu Glu Asn Val Ser Gly Tyr Tyr Ala 
        35                  40                  45              


Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr Ala Gly Ser 
    50                  55                  60                  


Cys Ser His Ser Phe Lys Arg Ser Phe Leu Glu Lys Lys Arg Phe Thr 
65                  70                  75                  80  


Glu Glu Ala Thr Lys Tyr Phe Arg Glu Arg Val Ser Pro Val His Leu 
                85                  90                  95      


Gln Ile Leu Leu Thr Asn Asn Glu Ala Trp Lys Arg Phe Val Thr Ala 
            100                 105                 110         


Ala Glu Leu Pro Arg Asp Glu Ala Asp Ala Leu Tyr Glu Ala Leu Lys 
        115                 120                 125             


Lys Leu Arg Thr Tyr Ala Ala Ile Glu Asp Glu Tyr Val Gln Gln Lys 
    130                 135                 140                 


Asp Glu Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe Pro Gln Val Lys 
145                 150                 155                 160 


Arg Lys Ile Gln Glu Ser Ile Glu Lys Leu Arg Ala Leu Ala Asn Gly 
                165                 170                 175     


Ile Glu Glu Val His Arg Gly Cys Thr Ile Ser Asn Val Val Ser Ser 
            180                 185                 190         


Ser Thr Gly Ala Ala Ser Gly Ile Met Ser Leu Ala Gly Leu Val Leu 
        195                 200                 205             


Ala Pro Phe Thr Ala Gly Thr Ser Leu Ala Leu Thr Ala Ala Gly Val 
    210                 215                 220                 


Gly Leu Gly Ala Ala Ser Ala Val Thr Gly Ile Thr Thr Ser Ile Val 
225                 230                 235                 240 


Glu His Ser Tyr Thr Ser Ser Ala Glu Ala Glu Ala Ser Arg Leu Thr 
                245                 250                 255     


Ala Thr Ser Ile Asp Arg Leu Lys Val Phe Lys Glu Val Met Arg Asp 
            260                 265                 270         


Ile Thr Pro Asn Leu Leu Ser Leu Leu Asn Asn Tyr Tyr Glu Ala Thr 
        275                 280                 285             


Gln Thr Ile Gly Ser Glu Ile Arg Ala Ile Arg Gln Ala Arg Ala Arg 
    290                 295                 300                 


Ala Arg Leu Pro Val Thr Thr Trp Arg Ile Ser Ala Gly Ser Gly Gly 
305                 310                 315                 320 


Gln Ala Glu Arg Thr Ile Ala Gly Thr Thr Arg Ala Val Ser Arg Gly 
                325                 330                 335     


Ala Arg Ile Leu Ser Ala Thr Thr Ser Gly Ile Phe Leu Ala Leu Asp 
            340                 345                 350         


Val Val Asn Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys 
        355                 360                 365             


Ser Ala Ser Ala Glu Glu Leu Arg Arg Gln Ala Gln Glu Leu Glu Glu 
    370                 375                 380                 


Asn Leu Met Glu Leu Thr Gln Ile Tyr Gln Arg Leu Asn Pro Cys His 
385                 390                 395                 400 


Thr His 
        


<210>  709
<211>  14882
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (565)..(14826)

<400>  709
aacggttcta acagctgggt gcgggtggag ctgcgggcga tcgccagctc gagtgcagat       60

tccttgctgt gaccgaggtt cagagtgagc tctgtcggtg tgtcagtttg cctcttcagg      120

cactcttcaa tgaaacctca tcagcagatc gggctctctt cccttgcctt gcctcctaac      180

ccccctaggc caggtgaggg ggacagggta ctgggaggta agaaggaact cttctgcaag      240

gagggctctc acgtctgtct taggcctgct ccttaccaga gtctttgggg aagcagtagg      300

gagggcctga gggtctcagg aaaggctctc tgctggtctg gctctgctct gtagctccat      360

ctatttccct gtcccaggtc ctttcttcct cctaacccca ttgactctga ccatcccctg      420

cccagagcct gaggtccctt ctctggcccc tctgctgggc tggcccatgc aggtgaggcc      480

ccgcatctgg catcctggaa ctggcagttg gagcctgagc tatgggcaag gtcacttcga      540

cagcagttga atgcccagct cctc atg gtc ccg gag gag agg agg gta ggt         591
                           Met Val Pro Glu Glu Arg Arg Val Gly            
                           1               5                              

ttg tct tct gat gag aca tca tct gat tcc ctt aag tct tgg cac tcc        639
Leu Ser Ser Asp Glu Thr Ser Ser Asp Ser Leu Lys Ser Trp His Ser           
10                  15                  20                  25            

ata tgt gtc ttg gac agc aaa gaa cag ccc ttg gcc tgc cag cag aaa        687
Ile Cys Val Leu Asp Ser Lys Glu Gln Pro Leu Ala Cys Gln Gln Lys           
                30                  35                  40                

cag agg cag ttc gtg aag cca gtg act gag tca gag cag ccc aca gtg        735
Gln Arg Gln Phe Val Lys Pro Val Thr Glu Ser Glu Gln Pro Thr Val           
            45                  50                  55                    

ctg gaa ctc ctg cta gct gag ctc cga act ctg ttc tca gct gtg ttg        783
Leu Glu Leu Leu Leu Ala Glu Leu Arg Thr Leu Phe Ser Ala Val Leu           
        60                  65                  70                        

cag gac agt agc cct gca gct tgg cgc tat ctt cat gca gta ctg ggt        831
Gln Asp Ser Ser Pro Ala Ala Trp Arg Tyr Leu His Ala Val Leu Gly           
    75                  80                  85                            

cta ctg cct cca tat cgt gag ttg cta gtt ggc cac ctt gat ttg ctg        879
Leu Leu Pro Pro Tyr Arg Glu Leu Leu Val Gly His Leu Asp Leu Leu           
90                  95                  100                 105           

ccc ttc ctg gag cag ctg tac tgc tgg gca ccc tgg gtc caa acc cac        927
Pro Phe Leu Glu Gln Leu Tyr Cys Trp Ala Pro Trp Val Gln Thr His           
                110                 115                 120               

ctc cat ctg gac ctg cta ggt gcc att gtc cag gcc ttt cct cca gac        975
Leu His Leu Asp Leu Leu Gly Ala Ile Val Gln Ala Phe Pro Pro Asp           
            125                 130                 135                   

agc tct ttg tta gac agt gct tcc cat gct gac tgc tgt ccc cag aag       1023
Ser Ser Leu Leu Asp Ser Ala Ser His Ala Asp Cys Cys Pro Gln Lys           
        140                 145                 150                       

cgg agg ctc cat cac agg ccc cca tgc cca gct tgc cct ttt gtg cag       1071
Arg Arg Leu His His Arg Pro Pro Cys Pro Ala Cys Pro Phe Val Gln           
    155                 160                 165                           

gcc cag tgg agc agg cag caa gta aag gag gag ctg gcc acc tgg ctg       1119
Ala Gln Trp Ser Arg Gln Gln Val Lys Glu Glu Leu Ala Thr Trp Leu           
170                 175                 180                 185           

cga cca ttg aca ctg cct gag cta cag cgc tgc ctg ggc att gtt ggt       1167
Arg Pro Leu Thr Leu Pro Glu Leu Gln Arg Cys Leu Gly Ile Val Gly           
                190                 195                 200               

gct cag gtg gcc cta gaa gag gct gtg tgg ctg gat gga ctt agt ctc       1215
Ala Gln Val Ala Leu Glu Glu Ala Val Trp Leu Asp Gly Leu Ser Leu           
            205                 210                 215                   

ctt ccc ttg gca ctg gca gcg gac atc cct gta cgg tat gaa agc agt       1263
Leu Pro Leu Ala Leu Ala Ala Asp Ile Pro Val Arg Tyr Glu Ser Ser           
        220                 225                 230                       

gac act gac aat gca gag gtg gag cct gtt gga aga aaa gag acc agg       1311
Asp Thr Asp Asn Ala Glu Val Glu Pro Val Gly Arg Lys Glu Thr Arg           
    235                 240                 245                           

tct cag ctt gac tat gaa gtt ccc agg gaa aag gcc ttc caa aag agc       1359
Ser Gln Leu Asp Tyr Glu Val Pro Arg Glu Lys Ala Phe Gln Lys Ser           
250                 255                 260                 265           

agc acc ggc ttt tca cct gag act tcc ttc ctg gat agc cag gtg atg       1407
Ser Thr Gly Phe Ser Pro Glu Thr Ser Phe Leu Asp Ser Gln Val Met           
                270                 275                 280               

act gct ctg aag atg gag aga tac ctg aag aag atc cac ttc ctc tat       1455
Thr Ala Leu Lys Met Glu Arg Tyr Leu Lys Lys Ile His Phe Leu Tyr           
            285                 290                 295                   

ctc aat gtg gct ccc agc cgg tac ttt agg cct tac agc ctg atg gtg       1503
Leu Asn Val Ala Pro Ser Arg Tyr Phe Arg Pro Tyr Ser Leu Met Val           
        300                 305                 310                       

gtg cca ccc gac aag gtg aat ccc gag cac tac atc ttc tct ccc ttt       1551
Val Pro Pro Asp Lys Val Asn Pro Glu His Tyr Ile Phe Ser Pro Phe           
    315                 320                 325                           

ggg atc ttg cat gta cat cct gtg gaa ggt agc gag acg atg aca ctg       1599
Gly Ile Leu His Val His Pro Val Glu Gly Ser Glu Thr Met Thr Leu           
330                 335                 340                 345           

ggt acc tgg cac cat cac tgt gtt ctc tgg cag cag ctc cag ttc att       1647
Gly Thr Trp His His His Cys Val Leu Trp Gln Gln Leu Gln Phe Ile           
                350                 355                 360               

cca ttc ttt aag tat tgc ctc tta cgc aag tcc ttt acc tgt tgg aag       1695
Pro Phe Phe Lys Tyr Cys Leu Leu Arg Lys Ser Phe Thr Cys Trp Lys           
            365                 370                 375                   

aag aat gtg aga tta cag ggg ctg cat cga ctc cag aaa ttc cta gag       1743
Lys Asn Val Arg Leu Gln Gly Leu His Arg Leu Gln Lys Phe Leu Glu           
        380                 385                 390                       

aat cat ctg ctc ttg gct gtg ccc cac ttt gga gct ggg cta ctc cat       1791
Asn His Leu Leu Leu Ala Val Pro His Phe Gly Ala Gly Leu Leu His           
    395                 400                 405                           

att agc agg ctt ctg cag gag cta cac tct gtg tcc tgg cta ccc cag       1839
Ile Ser Arg Leu Leu Gln Glu Leu His Ser Val Ser Trp Leu Pro Gln           
410                 415                 420                 425           

gaa ctg gat cgg tgc tat gag ctg ctg gac ctg cag acg gct cta gcc       1887
Glu Leu Asp Arg Cys Tyr Glu Leu Leu Asp Leu Gln Thr Ala Leu Ala           
                430                 435                 440               

gag gag aag cat aag gct cta cgg ctg ctc cat cgt tgc cta aac ctc       1935
Glu Glu Lys His Lys Ala Leu Arg Leu Leu His Arg Cys Leu Asn Leu           
            445                 450                 455                   

tgc aca tcc att ctt cga ctg gtt cac gag gac aca tac cac atg caa       1983
Cys Thr Ser Ile Leu Arg Leu Val His Glu Asp Thr Tyr His Met Gln           
        460                 465                 470                       

cag tgc cta cag gag cga gta caa aac tgt gac agg atc agg aca ggc       2031
Gln Cys Leu Gln Glu Arg Val Gln Asn Cys Asp Arg Ile Arg Thr Gly           
    475                 480                 485                           

caa ggc tcc ata tac ctt cag agg gta cag cac aag caa ctg gag cag       2079
Gln Gly Ser Ile Tyr Leu Gln Arg Val Gln His Lys Gln Leu Glu Gln           
490                 495                 500                 505           

aag ctg aag caa gca gag gcc tgg tgg ctg cag ctg gga aag ttt gcc       2127
Lys Leu Lys Gln Ala Glu Ala Trp Trp Leu Gln Leu Gly Lys Phe Ala           
                510                 515                 520               

cgc ctg gtt gac tac atg att tgt cag agc ctc att tct gtc ttg gaa       2175
Arg Leu Val Asp Tyr Met Ile Cys Gln Ser Leu Ile Ser Val Leu Glu           
            525                 530                 535                   

gag cag ata acc tct ttt gtg gcc aac atc ctt caa gcc cca agg cag       2223
Glu Gln Ile Thr Ser Phe Val Ala Asn Ile Leu Gln Ala Pro Arg Gln           
        540                 545                 550                       

aaa ccc ttt ctc tca tca cag ctg gtc ttt gat gat cat ggt caa ctg       2271
Lys Pro Phe Leu Ser Ser Gln Leu Val Phe Asp Asp His Gly Gln Leu           
    555                 560                 565                           

tct cat gtg ccc tgt gtt gaa aat atg atc cag act cta act gga ggc       2319
Ser His Val Pro Cys Val Glu Asn Met Ile Gln Thr Leu Thr Gly Gly           
570                 575                 580                 585           

cta cag tct gtc aag acc tct gcc ttg cag gta gtg cag tct gca gac       2367
Leu Gln Ser Val Lys Thr Ser Ala Leu Gln Val Val Gln Ser Ala Asp           
                590                 595                 600               

ctg aag acc tcc tcg gat tcc ctg tat tct gaa gaa gaa gat gaa gag       2415
Leu Lys Thr Ser Ser Asp Ser Leu Tyr Ser Glu Glu Glu Asp Glu Glu           
            605                 610                 615                   

gag gac tca aaa gac gaa ttt ctg atg ccc aag ttc cag ggc cag ccc       2463
Glu Asp Ser Lys Asp Glu Phe Leu Met Pro Lys Phe Gln Gly Gln Pro           
        620                 625                 630                       

agc gat gct gtg agc atc ttc tgt ggc ccg aat gtg gga ttg gtg tgg       2511
Ser Asp Ala Val Ser Ile Phe Cys Gly Pro Asn Val Gly Leu Val Trp           
    635                 640                 645                           

ccc tgg aag tct cac cca att gct ggt atc ttg gag gtc cgt gga tgt       2559
Pro Trp Lys Ser His Pro Ile Ala Gly Ile Leu Glu Val Arg Gly Cys           
650                 655                 660                 665           

cgg ctg cgg ggc caa tac ttc ccc cac aat tat aag cag ctg gag gaa       2607
Arg Leu Arg Gly Gln Tyr Phe Pro His Asn Tyr Lys Gln Leu Glu Glu           
                670                 675                 680               

gac ctg gac aac aac cct aag atc cag cag gca ctg aat ata caa cag       2655
Asp Leu Asp Asn Asn Pro Lys Ile Gln Gln Ala Leu Asn Ile Gln Gln           
            685                 690                 695                   

gtg ctg ctg gag ggc gtg ctg tgc aag gtg cag gaa ttc tgc agg gaa       2703
Val Leu Leu Glu Gly Val Leu Cys Lys Val Gln Glu Phe Cys Arg Glu           
        700                 705                 710                       

cat cat tgg ata aca ggc att tat gaa ttc ctg caa tcc tgg ggg cct       2751
His His Trp Ile Thr Gly Ile Tyr Glu Phe Leu Gln Ser Trp Gly Pro           
    715                 720                 725                           

cag aag ctg gaa gac atg aga ggt ggt ccc atc aag aac tac gtg acg       2799
Gln Lys Leu Glu Asp Met Arg Gly Gly Pro Ile Lys Asn Tyr Val Thr           
730                 735                 740                 745           

ctg gtg agc cgc ctg aat gtt tgg cag gcc cgt gtc tcc agt atg cct       2847
Leu Val Ser Arg Leu Asn Val Trp Gln Ala Arg Val Ser Ser Met Pro           
                750                 755                 760               

atc gag ttg ctc aca aaa ggc ggg ttg ctg cta ctt agc tgc cat gat       2895
Ile Glu Leu Leu Thr Lys Gly Gly Leu Leu Leu Leu Ser Cys His Asp           
            765                 770                 775                   

gta cag gca gag atg gaa tcc aag ctg aac agc ata agg aag gac att       2943
Val Gln Ala Glu Met Glu Ser Lys Leu Asn Ser Ile Arg Lys Asp Ile           
        780                 785                 790                       

ctt gca cac gtg caa aat gag tgc tgg aac ctc agt caa caa ctc atg       2991
Leu Ala His Val Gln Asn Glu Cys Trp Asn Leu Ser Gln Gln Leu Met           
    795                 800                 805                           

aca gag ctc aca gat ttc atg cat atc ttc cga acc atc aac tca gat       3039
Thr Glu Leu Thr Asp Phe Met His Ile Phe Arg Thr Ile Asn Ser Asp           
810                 815                 820                 825           

att cat gcc att gca cag tgc acc cag aag ttg aat gaa gcc aat gaa       3087
Ile His Ala Ile Ala Gln Cys Thr Gln Lys Leu Asn Glu Ala Asn Glu           
                830                 835                 840               

cag tac gtc gag ctg gag gag cga atg gaa tac gta cgg gca ctc cac       3135
Gln Tyr Val Glu Leu Glu Glu Arg Met Glu Tyr Val Arg Ala Leu His           
            845                 850                 855                   

gaa ctc atc cgc aac cac ttt agc ctc ttt agt gct gag aat gaa gca       3183
Glu Leu Ile Arg Asn His Phe Ser Leu Phe Ser Ala Glu Asn Glu Ala           
        860                 865                 870                       

ctg gac atc tcg gtg aga agg caa ttc ggg gag tca ccc atc cct ccc       3231
Leu Asp Ile Ser Val Arg Arg Gln Phe Gly Glu Ser Pro Ile Pro Pro           
    875                 880                 885                           

tgc cct cct ccc cca caa cca cat cta ctc cac tgc cct ctg ctt gcc       3279
Cys Pro Pro Pro Pro Gln Pro His Leu Leu His Cys Pro Leu Leu Ala           
890                 895                 900                 905           

cca cag ctt ctg gat atg tgg gag gca ttt cag ttt gag aaa agc cag       3327
Pro Gln Leu Leu Asp Met Trp Glu Ala Phe Gln Phe Glu Lys Ser Gln           
                910                 915                 920               

gct tca gag ttc ctg ctc agc aag cga cat gcc att atg ccc aag ctg       3375
Ala Ser Glu Phe Leu Leu Ser Lys Arg His Ala Ile Met Pro Lys Leu           
            925                 930                 935                   

cag cag ctg atg gca gca gca ttg gca gag ctg gaa ggc ctg ctt gcg       3423
Gln Gln Leu Met Ala Ala Ala Leu Ala Glu Leu Glu Gly Leu Leu Ala           
        940                 945                 950                       

aag gcc ctc tcc ggt ccc ttt atg gac ccc aca caa gat cag agg agt       3471
Lys Ala Leu Ser Gly Pro Phe Met Asp Pro Thr Gln Asp Gln Arg Ser           
    955                 960                 965                           

act gag cac cag ctc gtc tcc cta gag cgt cag ttc cag aac aca gtc       3519
Thr Glu His Gln Leu Val Ser Leu Glu Arg Gln Phe Gln Asn Thr Val           
970                 975                 980                 985           

agc gac ctc agt gaa ctg cac cac gcc tat gcc atc ttc act gag  gat      3567
Ser Asp Leu Ser Glu Leu His His Ala Tyr Ala Ile Phe Thr Glu  Asp          
                990                 995                 1000              

gag act cct gtg  ccc ttg cca atc tgt  ggg aca cgt cct att  gtg        3612
Glu Thr Pro Val  Pro Leu Pro Ile Cys  Gly Thr Arg Pro Ile  Val            
            1005                 1010                 1015                

cag cag cag cgc  ata tgg cac ctg tac  cga gtc atc tcc gaa  aac        3657
Gln Gln Gln Arg  Ile Trp His Leu Tyr  Arg Val Ile Ser Glu  Asn            
            1020                 1025                 1030                

atc agc gag tgg  aag tgc atg gct ttt  gcc aag ttc agc cca  gct        3702
Ile Ser Glu Trp  Lys Cys Met Ala Phe  Ala Lys Phe Ser Pro  Ala            
            1035                 1040                 1045                

atg gcc cag gag  aag aca gag ggc tgg  ctg aca gag gca gca  cgg        3747
Met Ala Gln Glu  Lys Thr Glu Gly Trp  Leu Thr Glu Ala Ala  Arg            
            1050                 1055                 1060                

atg agc aca acc  ctg gag ctg cac agc  ccc gtg ctg cag cac  tgc        3792
Met Ser Thr Thr  Leu Glu Leu His Ser  Pro Val Leu Gln His  Cys            
            1065                 1070                 1075                

atg cgc atc ctg  ggg gag ttt cgc agc  tac ctg ccc ctg ctc  act        3837
Met Arg Ile Leu  Gly Glu Phe Arg Ser  Tyr Leu Pro Leu Leu  Thr            
            1080                 1085                 1090                

aag ctg ggc agc  ctc cac cca cag agc  ctc aac tgc cag tgt  ctc        3882
Lys Leu Gly Ser  Leu His Pro Gln Ser  Leu Asn Cys Gln Cys  Leu            
            1095                 1100                 1105                

ctg cgt gcc ctt  ggg ctg ggc agt ctc  caa act ata gaa ctc  cta        3927
Leu Arg Ala Leu  Gly Leu Gly Ser Leu  Gln Thr Ile Glu Leu  Leu            
            1110                 1115                 1120                

acg ctg ggc cag  ctg ctt act tat cca  ctg ctg gag ttt gca  gat        3972
Thr Leu Gly Gln  Leu Leu Thr Tyr Pro  Leu Leu Glu Phe Ala  Asp            
            1125                 1130                 1135                

cga atc aac cag  gtc tgg cag aat gaa  aat gaa cga att cat  gcc        4017
Arg Ile Asn Gln  Val Trp Gln Asn Glu  Asn Glu Arg Ile His  Ala            
            1140                 1145                 1150                

caa gag act ata  cgg cgg ttg cag cgg  tac tgg gaa gcg cgc  cag        4062
Gln Glu Thr Ile  Arg Arg Leu Gln Arg  Tyr Trp Glu Ala Arg  Gln            
            1155                 1160                 1165                

ctg cgc ctg ctc  aac ttc atc ctg cat  gta ccc tac gag ccc  cca        4107
Leu Arg Leu Leu  Asn Phe Ile Leu His  Val Pro Tyr Glu Pro  Pro            
            1170                 1175                 1180                

gcc tca gag cgc  tcc aag agg cag gtg  ctc cgc agc ccc caa  tgg        4152
Ala Ser Glu Arg  Ser Lys Arg Gln Val  Leu Arg Ser Pro Gln  Trp            
            1185                 1190                 1195                

gag gta gtg gac  aaa gat agt ggc acc  ttc atc ctc tca gat  tac        4197
Glu Val Val Asp  Lys Asp Ser Gly Thr  Phe Ile Leu Ser Asp  Tyr            
            1200                 1205                 1210                

agc aac ctg cag  gat tcc atc cag gaa  agt ctt cag gtg ttg  tcc        4242
Ser Asn Leu Gln  Asp Ser Ile Gln Glu  Ser Leu Gln Val Leu  Ser            
            1215                 1220                 1225                

aag atc ttg gcc  atc gaa aag tca gga  gat tta aac aaa ata  gct        4287
Lys Ile Leu Ala  Ile Glu Lys Ser Gly  Asp Leu Asn Lys Ile  Ala            
            1230                 1235                 1240                

ttg gag tgg gtg  gcc atc atg cat ggc  ctg ggt gcc ctg ctg  gag        4332
Leu Glu Trp Val  Ala Ile Met His Gly  Leu Gly Ala Leu Leu  Glu            
            1245                 1250                 1255                

gtg tgg ctg act  ttc cag cag aag tgg  att ttt ctg aat aaa  gtt        4377
Val Trp Leu Thr  Phe Gln Gln Lys Trp  Ile Phe Leu Asn Lys  Val            
            1260                 1265                 1270                

ctg cat gag atg  aag atc cag ttt cct  aat gct gac ctg aac  tct        4422
Leu His Glu Met  Lys Ile Gln Phe Pro  Asn Ala Asp Leu Asn  Ser            
            1275                 1280                 1285                

cgt ttc aag gtc  atg gat gac cag tat  cga acc ctg atg cgc  atc        4467
Arg Phe Lys Val  Met Asp Asp Gln Tyr  Arg Thr Leu Met Arg  Ile            
            1290                 1295                 1300                

tct gta gct gac  ccc atg gtt ctg tca  ctt gta gtg ccc agt  gcc        4512
Ser Val Ala Asp  Pro Met Val Leu Ser  Leu Val Val Pro Ser  Ala            
            1305                 1310                 1315                

gag agg agc cct  tac ttc caa ggc cag  cag ctg caa caa ctg  ctg        4557
Glu Arg Ser Pro  Tyr Phe Gln Gly Gln  Gln Leu Gln Gln Leu  Leu            
            1320                 1325                 1330                

caa gca gga tcg  gtg gag ctg gag ggc  atc atc atg agt ctg  gag        4602
Gln Ala Gly Ser  Val Glu Leu Glu Gly  Ile Ile Met Ser Leu  Glu            
            1335                 1340                 1345                

agc gtg ctc tat  ggg gtg tgt gct cac  ttc ccc cgc ctc ttc  ttc        4647
Ser Val Leu Tyr  Gly Val Cys Ala His  Phe Pro Arg Leu Phe  Phe            
            1350                 1355                 1360                

ctt agt gac agt  gag ctg gta gcc ctg  ctg gct gct cga ctg  gaa        4692
Leu Ser Asp Ser  Glu Leu Val Ala Leu  Leu Ala Ala Arg Leu  Glu            
            1365                 1370                 1375                

tca tgc gaa gcc  cag cta tgg gta cga  cgc tgc ttt cct cat  gtg        4737
Ser Cys Glu Ala  Gln Leu Trp Val Arg  Arg Cys Phe Pro His  Val            
            1380                 1385                 1390                

cat gct gtg agc  ttc agg tct tgc cca  act ggt gag aaa aac  aca        4782
His Ala Val Ser  Phe Arg Ser Cys Pro  Thr Gly Glu Lys Asn  Thr            
            1395                 1400                 1405                

gat gac tgg gag  tca agc cca aac aca  cag act cag gtg gag  gca        4827
Asp Asp Trp Glu  Ser Ser Pro Asn Thr  Gln Thr Gln Val Glu  Ala            
            1410                 1415                 1420                

ctt gca gtg cta  ggg gca ggt ggg gag  gag gtg aag ctg cag  ggt        4872
Leu Ala Val Leu  Gly Ala Gly Gly Glu  Glu Val Lys Leu Gln  Gly            
            1425                 1430                 1435                

ccc ctt cct ctg  cat cca gat ctc cct  aag tgg ctg gcc tct  ctg        4917
Pro Leu Pro Leu  His Pro Asp Leu Pro  Lys Trp Leu Ala Ser  Leu            
            1440                 1445                 1450                

gag aag tgt ctg  cgc ttg gca ctg gtg  cac atg ctg cag ggc  tgt        4962
Glu Lys Cys Leu  Arg Leu Ala Leu Val  His Met Leu Gln Gly  Cys            
            1455                 1460                 1465                

gtg gct gct cgc  ctt gct cga ggc cca  tct cta ggt gag gcc  ctc        5007
Val Ala Ala Arg  Leu Ala Arg Gly Pro  Ser Leu Gly Glu Ala  Leu            
            1470                 1475                 1480                

aag caa ctg ccc  aag caa aac aag ttg  tac ctg caa ctg tat  gtc        5052
Lys Gln Leu Pro  Lys Gln Asn Lys Leu  Tyr Leu Gln Leu Tyr  Val            
            1485                 1490                 1495                

cag cac tgg atc  gac tta gtc cag gcc  ttc cca tgg cag tgt  gtg        5097
Gln His Trp Ile  Asp Leu Val Gln Ala  Phe Pro Trp Gln Cys  Val            
            1500                 1505                 1510                

ctg gtg gca gag  gag gtg gta tgg cgg  gcc gag atg gag gag  gct        5142
Leu Val Ala Glu  Glu Val Val Trp Arg  Ala Glu Met Glu Glu  Ala            
            1515                 1520                 1525                

ctg ctt gag tgg  ggt acc ctg gcc atg  gtc tcc atg cat atg  cgc        5187
Leu Leu Glu Trp  Gly Thr Leu Ala Met  Val Ser Met His Met  Arg            
            1530                 1535                 1540                

aag ctt gag gta  ctg gtg aat ttt atg  cgg gcc cag agg gct  tcc        5232
Lys Leu Glu Val  Leu Val Asn Phe Met  Arg Ala Gln Arg Ala  Ser            
            1545                 1550                 1555                

caa ggt ggg cag  tcc ctg cct tct gtc  cgc cag acc agc ctt  ctc        5277
Gln Gly Gly Gln  Ser Leu Pro Ser Val  Arg Gln Thr Ser Leu  Leu            
            1560                 1565                 1570                

agt gcc ctg ctg  gtc atg gca gtg act  cac cgg gat ata gca  cag        5322
Ser Ala Leu Leu  Val Met Ala Val Thr  His Arg Asp Ile Ala  Gln            
            1575                 1580                 1585                

ctg ctg gaa cag  cac cag gtc agt gat  ctc aca gac ttt cac  tgg        5367
Leu Leu Glu Gln  His Gln Val Ser Asp  Leu Thr Asp Phe His  Trp            
            1590                 1595                 1600                

gtc cgc caa ctc  aag tat cac ttg ggt  tca cct cac ata atc  ccc        5412
Val Arg Gln Leu  Lys Tyr His Leu Gly  Ser Pro His Ile Ile  Pro            
            1605                 1610                 1615                

aaa agc ccc cta  cag agt ctt aag act  att gca tct tct gaa  ccc        5457
Lys Ser Pro Leu  Gln Ser Leu Lys Thr  Ile Ala Ser Ser Glu  Pro            
            1620                 1625                 1630                

tct ctg tca cca  gcg gca tgc tgg ata  gat gtg cta ggc agg  tcc        5502
Ser Leu Ser Pro  Ala Ala Cys Trp Ile  Asp Val Leu Gly Arg  Ser            
            1635                 1640                 1645                

ttc ctg tac aat  tac gag tat ctg gga  cct aga cta ggg cct  cta        5547
Phe Leu Tyr Asn  Tyr Glu Tyr Leu Gly  Pro Arg Leu Gly Pro  Leu            
            1650                 1655                 1660                

ccc agc cta ctg  cct gaa cgg cca gcc  ctg gta cta tta ttg  gcc        5592
Pro Ser Leu Leu  Pro Glu Arg Pro Ala  Leu Val Leu Leu Leu  Ala            
            1665                 1670                 1675                

cta gag gag gtg  gcc tgt ggg acc gta  ctg ggt cct aat ggt  gtg        5637
Leu Glu Glu Val  Ala Cys Gly Thr Val  Leu Gly Pro Asn Gly  Val            
            1680                 1685                 1690                

ggc aag aga gct  ata gtg aac agc ctg  gca cag gcc ctg ggc  cgc        5682
Gly Lys Arg Ala  Ile Val Asn Ser Leu  Ala Gln Ala Leu Gly  Arg            
            1695                 1700                 1705                

cag ctg gtg atg  cta ccc tgc tca cct  cag ata gag gct caa  tgc        5727
Gln Leu Val Met  Leu Pro Cys Ser Pro  Gln Ile Glu Ala Gln  Cys            
            1710                 1715                 1720                

ctg agc aac tat  ctg aat ggt gcc ctg  cag ggt ggt gcc tgg  ctg        5772
Leu Ser Asn Tyr  Leu Asn Gly Ala Leu  Gln Gly Gly Ala Trp  Leu            
            1725                 1730                 1735                

ctg ttg gag aaa  gtt cat cag ctg ccc  cct ggc ttg ctc tct  gcc        5817
Leu Leu Glu Lys  Val His Gln Leu Pro  Pro Gly Leu Leu Ser  Ala            
            1740                 1745                 1750                

ctg ggc cag cgc  ctg ggt gaa ctg cac  cac ttg tat gcc cca  ctg        5862
Leu Gly Gln Arg  Leu Gly Glu Leu His  His Leu Tyr Ala Pro  Leu            
            1755                 1760                 1765                

tac cag gag gct  tcc cga aac aca agc  acc ata gac ccc acc  cag        5907
Tyr Gln Glu Ala  Ser Arg Asn Thr Ser  Thr Ile Asp Pro Thr  Gln            
            1770                 1775                 1780                

ccc cag ctc ctt  ggc agt agc ttc ttt  gaa aaa cat cac gtg  tct        5952
Pro Gln Leu Leu  Gly Ser Ser Phe Phe  Glu Lys His His Val  Ser            
            1785                 1790                 1795                

gtg cgc ctt ggc  tat ggc tgt ctc ctg  gta ctg cgt gcc ctg  agc        5997
Val Arg Leu Gly  Tyr Gly Cys Leu Leu  Val Leu Arg Ala Leu  Ser            
            1800                 1805                 1810                

tct gct gtg cct  gcc aac ctg cac ctg  ctg ctg cgg cct gtg  gca        6042
Ser Ala Val Pro  Ala Asn Leu His Leu  Leu Leu Arg Pro Val  Ala            
            1815                 1820                 1825                

ttg gca ttg cct  gat ctg cgg caa gtg  gca gag ctg act ctg  ctg        6087
Leu Ala Leu Pro  Asp Leu Arg Gln Val  Ala Glu Leu Thr Leu  Leu            
            1830                 1835                 1840                

ggt gca ggg atg  agg gat gcc ttc cag  atg gct acc cgc cta  tcc        6132
Gly Ala Gly Met  Arg Asp Ala Phe Gln  Met Ala Thr Arg Leu  Ser            
            1845                 1850                 1855                

aaa ttc ttc tct  cta gag cgt gag ctg  gtg tct ggg ccc ctg  ccc        6177
Lys Phe Phe Ser  Leu Glu Arg Glu Leu  Val Ser Gly Pro Leu  Pro            
            1860                 1865                 1870                

tgc cgc ctg cca  ctg ctc aag cag ata  ctg gaa gac aca ata  cgg        6222
Cys Arg Leu Pro  Leu Leu Lys Gln Ile  Leu Glu Asp Thr Ile  Arg            
            1875                 1880                 1885                

aca cta aat gtg  acc aag gag gaa ccg  aag tgc cag aag cct  cgc        6267
Thr Leu Asn Val  Thr Lys Glu Glu Pro  Lys Cys Gln Lys Pro  Arg            
            1890                 1895                 1900                

agc cta gct gcc  att gag gag gct gcc  cta ctg cgc tca cca  ctg        6312
Ser Leu Ala Ala  Ile Glu Glu Ala Ala  Leu Leu Arg Ser Pro  Leu            
            1905                 1910                 1915                

ttt agc att ctc  aat ggg ctc cac ctg  cac aac ctc cga ggg  ctg        6357
Phe Ser Ile Leu  Asn Gly Leu His Leu  His Asn Leu Arg Gly  Leu            
            1920                 1925                 1930                

ttg tgt gcg ctt  ttc cct agc gcc agc  caa gtg ctg gca gaa  cct        6402
Leu Cys Ala Leu  Phe Pro Ser Ala Ser  Gln Val Leu Ala Glu  Pro            
            1935                 1940                 1945                

atg act tac aag  ctg atg aag cca ttg  gtg gtg gag gaa ctg  caa        6447
Met Thr Tyr Lys  Leu Met Lys Pro Leu  Val Val Glu Glu Leu  Gln            
            1950                 1955                 1960                

cag gta ggt ctg  gat ccc agc cct gac  att ttg ggg tcc ttg  gaa        6492
Gln Val Gly Leu  Asp Pro Ser Pro Asp  Ile Leu Gly Ser Leu  Glu            
            1965                 1970                 1975                

cag ttg agc cag  gcc ctg agc cgg gcc  tca ggc att ctg ctc  ctg        6537
Gln Leu Ser Gln  Ala Leu Ser Arg Ala  Ser Gly Ile Leu Leu  Leu            
            1980                 1985                 1990                

ggc cct gcg ggc  agc ggc aag acc act  tgt tgg cac agc tta  ttt        6582
Gly Pro Ala Gly  Ser Gly Lys Thr Thr  Cys Trp His Ser Leu  Phe            
            1995                 2000                 2005                

aag atc cag aat  cgg ctg gca gcc atg  gag gac acc tca acc  caa        6627
Lys Ile Gln Asn  Arg Leu Ala Ala Met  Glu Asp Thr Ser Thr  Gln            
            2010                 2015                 2020                

ggc tgc cag cct  gtg gaa att acc cac  ctg tac ccc agt ggc  ctc        6672
Gly Cys Gln Pro  Val Glu Ile Thr His  Leu Tyr Pro Ser Gly  Leu            
            2025                 2030                 2035                

agc ccc cag gag  ttc ctg gga tgg cta  gag ggc tcc tgc tgg  cat        6717
Ser Pro Gln Glu  Phe Leu Gly Trp Leu  Glu Gly Ser Cys Trp  His            
            2040                 2045                 2050                

cat ggc atc ttt  ccc aag gta ctt cgt  gca gcc ggt cag tgt  aac        6762
His Gly Ile Phe  Pro Lys Val Leu Arg  Ala Ala Gly Gln Cys  Asn            
            2055                 2060                 2065                

aac atg ggc caa  aag agg cag aca gag  gaa tca atc ggg atc  cag        6807
Asn Met Gly Gln  Lys Arg Gln Thr Glu  Glu Ser Ile Gly Ile  Gln            
            2070                 2075                 2080                

cac tgg ata ata  tgt gat gga gcc tcc  aat ggt gct tgg ctg  gac        6852
His Trp Ile Ile  Cys Asp Gly Ala Ser  Asn Gly Ala Trp Leu  Asp            
            2085                 2090                 2095                

tcc atc act tgc  ctc ctg agt gag ctt  ccc cag ctt agt ctc  ccc        6897
Ser Ile Thr Cys  Leu Leu Ser Glu Leu  Pro Gln Leu Ser Leu  Pro            
            2100                 2105                 2110                

agt gga cag cag  ata gca cga ccc cca  ggc acc ttt ctc ttg  atg        6942
Ser Gly Gln Gln  Ile Ala Arg Pro Pro  Gly Thr Phe Leu Leu  Met            
            2115                 2120                 2125                

gag gtg gct gac  aca aca ggc ata tcc  ccc aca gtg gta ggc  tgt        6987
Glu Val Ala Asp  Thr Thr Gly Ile Ser  Pro Thr Val Val Gly  Cys            
            2130                 2135                 2140                

tgt gcc cta gtc  tgg tgt ggt gga gag  cag act tgg cag tgt  ata        7032
Cys Ala Leu Val  Trp Cys Gly Gly Glu  Gln Thr Trp Gln Cys  Ile            
            2145                 2150                 2155                

ctt agt gcc ctg  atg gca tcc ctt cct  tat gag tac cgc ctg  cag        7077
Leu Ser Ala Leu  Met Ala Ser Leu Pro  Tyr Glu Tyr Arg Leu  Gln            
            2160                 2165                 2170                

cac cgg aca gtc  gct gag ctc aac cac  atg gct gag gtt ctg  gtg        7122
His Arg Thr Val  Ala Glu Leu Asn His  Met Ala Glu Val Leu  Val            
            2175                 2180                 2185                

cct gca aca ttg  cga ttc ctc acc tgc  caa ggt gtc agc tct  ctg        7167
Pro Ala Thr Leu  Arg Phe Leu Thr Cys  Gln Gly Val Ser Ser  Leu            
            2190                 2195                 2200                

ctg cag gta cac  ggg cag cag gct gtt  tgt gca ggt gtg gca  gaa        7212
Leu Gln Val His  Gly Gln Gln Ala Val  Cys Ala Gly Val Ala  Glu            
            2205                 2210                 2215                

gtt acc agc atg  gca cgc atc ttg cat  agt ctg ctt gac ctc  cac        7257
Val Thr Ser Met  Ala Arg Ile Leu His  Ser Leu Leu Asp Leu  His            
            2220                 2225                 2230                

ctt cgc cta aag  gag gag aag gcc cct  ggc cca gag gac ctc  agc        7302
Leu Arg Leu Lys  Glu Glu Lys Ala Pro  Gly Pro Glu Asp Leu  Ser            
            2235                 2240                 2245                

tat agt gat cct  gtg gcc caa agc ttc  agg tct tca aaa agc  agc        7347
Tyr Ser Asp Pro  Val Ala Gln Ser Phe  Arg Ser Ser Lys Ser  Ser            
            2250                 2255                 2260                

ttt cta aac cgg  tcc cag gtt gac agt  gac gat gtg cca gat  aag        7392
Phe Leu Asn Arg  Ser Gln Val Asp Ser  Asp Asp Val Pro Asp  Lys            
            2265                 2270                 2275                

tgc agg gaa cac  ttg ctg gct gtc agc  agt ttt ctt ttt gcc  ttg        7437
Cys Arg Glu His  Leu Leu Ala Val Ser  Ser Phe Leu Phe Ala  Leu            
            2280                 2285                 2290                

atc tgg ggc ttt  gga gcc cac ctt ccc  tcc agg ttc tgg ccc  atc        7482
Ile Trp Gly Phe  Gly Ala His Leu Pro  Ser Arg Phe Trp Pro  Ile            
            2295                 2300                 2305                

ttt gat acc ttc  ata agg gat tct att  agt cgc ctc tcc aac  tac        7527
Phe Asp Thr Phe  Ile Arg Asp Ser Ile  Ser Arg Leu Ser Asn  Tyr            
            2310                 2315                 2320                

cct gag cca cca  ccc tca gcc ttg gtg  ttt gat cta cat gta  agc        7572
Pro Glu Pro Pro  Pro Ser Ala Leu Val  Phe Asp Leu His Val  Ser            
            2325                 2330                 2335                

cct gaa gat gga  aca ctg gtc ccc ttc  act ggc caa tac ctg  agc        7617
Pro Glu Asp Gly  Thr Leu Val Pro Phe  Thr Gly Gln Tyr Leu  Ser            
            2340                 2345                 2350                

agc cac atc aaa  gga act ttg ggc acc  ttt cac cct tct atc  cag        7662
Ser His Ile Lys  Gly Thr Leu Gly Thr  Phe His Pro Ser Ile  Gln            
            2355                 2360                 2365                

act gaa cgg ctc  ttg tat gtg gtg gac  ctg ctt ctg tca ggg  gga        7707
Thr Glu Arg Leu  Leu Tyr Val Val Asp  Leu Leu Leu Ser Gly  Gly            
            2370                 2375                 2380                

cag cca gtg ttg  ctg gct gga gag gca  gca aca ggg aag tca  gcc        7752
Gln Pro Val Leu  Leu Ala Gly Glu Ala  Ala Thr Gly Lys Ser  Ala            
            2385                 2390                 2395                

ttt gtg gag gtg  ctg gta gag cca cat  cac cct tac ata tac  agc        7797
Phe Val Glu Val  Leu Val Glu Pro His  His Pro Tyr Ile Tyr  Ser            
            2400                 2405                 2410                

ccc atc cac cct  gcc ttc agt tcc tcc  cac ctc cgt ctc ctg  ctg        7842
Pro Ile His Pro  Ala Phe Ser Ser Ser  His Leu Arg Leu Leu  Leu            
            2415                 2420                 2425                

agc aga gga atc  cag ggc caa aca caa  gcc agc cca cag cct  ggg        7887
Ser Arg Gly Ile  Gln Gly Gln Thr Gln  Ala Ser Pro Gln Pro  Gly            
            2430                 2435                 2440                

cat cac cag gat  tct aaa ccc tcc ctc  ctc ttc ttg ctg gag  gac        7932
His His Gln Asp  Ser Lys Pro Ser Leu  Leu Phe Leu Leu Glu  Asp            
            2445                 2450                 2455                

ctg cac cta gcc  act tct gac cca gag  aag agc tgc cag cca  gtg        7977
Leu His Leu Ala  Thr Ser Asp Pro Glu  Lys Ser Cys Gln Pro  Val            
            2460                 2465                 2470                

ttg gag act ctg  cgc cag gcc atg gat  ggc act gtg tat gcc  cac        8022
Leu Glu Thr Leu  Arg Gln Ala Met Asp  Gly Thr Val Tyr Ala  His            
            2475                 2480                 2485                

agc acc ttg gaa  ctg cag acg ctg cag  cct aca gtc aac ttc  ctt        8067
Ser Thr Leu Glu  Leu Gln Thr Leu Gln  Pro Thr Val Asn Phe  Leu            
            2490                 2495                 2500                

gcc act gtc aca  gtg cca gga tac tgt  gag cgc cca ctg tgt  cca        8112
Ala Thr Val Thr  Val Pro Gly Tyr Cys  Glu Arg Pro Leu Cys  Pro            
            2505                 2510                 2515                

cgc ctc ttt cga  ctc ttc aca gtc ctg  gcc ctg gaa agc atg  acc        8157
Arg Leu Phe Arg  Leu Phe Thr Val Leu  Ala Leu Glu Ser Met  Thr            
            2520                 2525                 2530                

cag gcc acc ctg  ctg gaa aga cat gtg  cct atc att cag gct  tgg        8202
Gln Ala Thr Leu  Leu Glu Arg His Val  Pro Ile Ile Gln Ala  Trp            
            2535                 2540                 2545                

ctt gag cgt ttc  cct tct gtg gaa cgg  gag cgt gct ctg gca  cga        8247
Leu Glu Arg Phe  Pro Ser Val Glu Arg  Glu Arg Ala Leu Ala  Arg            
            2550                 2555                 2560                

ggt ctg gtt agg  gcc tca gta gag gcc  tgg gag gct gtg tgc  aat        8292
Gly Leu Val Arg  Ala Ser Val Glu Ala  Trp Glu Ala Val Cys  Asn            
            2565                 2570                 2575                

tgc ttc atg cct  tca ccc ctc cac cca  cac tac cac ttc tcc  cta        8337
Cys Phe Met Pro  Ser Pro Leu His Pro  His Tyr His Phe Ser  Leu            
            2580                 2585                 2590                

cac tct gtg agc  cac cta ctg agc agc  ctg cag ctg ctg ccc  aac        8382
His Ser Val Ser  His Leu Leu Ser Ser  Leu Gln Leu Leu Pro  Asn            
            2595                 2600                 2605                

aga aca ggc tcc  cga ggt ttt gtg gac  tat ccc aac cac cag  gag        8427
Arg Thr Gly Ser  Arg Gly Phe Val Asp  Tyr Pro Asn His Gln  Glu            
            2610                 2615                 2620                

cac ttg cgc cgg  gtg tca ggc ctg cga  ggc act tgt ctg acc  gtt        8472
His Leu Arg Arg  Val Ser Gly Leu Arg  Gly Thr Cys Leu Thr  Val            
            2625                 2630                 2635                

atg atg gcc aca  cgc aat gtg gtg cgt  ctt tgg ttg cat gag  gca        8517
Met Met Ala Thr  Arg Asn Val Val Arg  Leu Trp Leu His Glu  Ala            
            2640                 2645                 2650                

cag aga acc ttt  tgc gac cgg ctg gac  agc ccc agg gaa cgc  tcc        8562
Gln Arg Thr Phe  Cys Asp Arg Leu Asp  Ser Pro Arg Glu Arg  Ser            
            2655                 2660                 2665                

tac tgt gcc aag  ctg ctc cta gta gta  gct caa agt gtc ttc  tgc        8607
Tyr Cys Ala Lys  Leu Leu Leu Val Val  Ala Gln Ser Val Phe  Cys            
            2670                 2675                 2680                

tgt ggg cca ggg  ccc cag cac ctg ggc  aag gac cat cag gag  agt        8652
Cys Gly Pro Gly  Pro Gln His Leu Gly  Lys Asp His Gln Glu  Ser            
            2685                 2690                 2695                

gag gag gag gag  gag gag gag agg gtg  ccc gaa gta gaa tct  gaa        8697
Glu Glu Glu Glu  Glu Glu Glu Arg Val  Pro Glu Val Glu Ser  Glu            
            2700                 2705                 2710                

ggg gag ttg gcc  cag tgg gag gac ttc  agc aac agc aat agt  gaa        8742
Gly Glu Leu Ala  Gln Trp Glu Asp Phe  Ser Asn Ser Asn Ser  Glu            
            2715                 2720                 2725                

aca gag gag gaa  gag gaa cct tat ggc  ctt cag gtc gcc aga  gtc        8787
Thr Glu Glu Glu  Glu Glu Pro Tyr Gly  Leu Gln Val Ala Arg  Val            
            2730                 2735                 2740                

tca aac tcc aga  gat cca agt cta aca  cca tcc ata gga cca  gta        8832
Ser Asn Ser Arg  Asp Pro Ser Leu Thr  Pro Ser Ile Gly Pro  Val            
            2745                 2750                 2755                

agc agg ggg atg  aag gaa agc ata agt  cac aag ata agg caa  gag        8877
Ser Arg Gly Met  Lys Glu Ser Ile Ser  His Lys Ile Arg Gln  Glu            
            2760                 2765                 2770                

aaa ggc aca agg  gca tcc aac tat agg  ctc cag gta agg aga  tca        8922
Lys Gly Thr Arg  Ala Ser Asn Tyr Arg  Leu Gln Val Arg Arg  Ser            
            2775                 2780                 2785                

ttc aag act tgg  tgg cag aag aaa ccc  cag atg gac ctg atc  tca        8967
Phe Lys Thr Trp  Trp Gln Lys Lys Pro  Gln Met Asp Leu Ile  Ser            
            2790                 2795                 2800                

ccc ttg ttg tta  cca gtg tta cta cta  cat ccc cag gaa aag  ccc        9012
Pro Leu Leu Leu  Pro Val Leu Leu Leu  His Pro Gln Glu Lys  Pro            
            2805                 2810                 2815                

tca gac ctg gtc  ttc agt cag gag ctg  ata ctg ggg cct aac  tct        9057
Ser Asp Leu Val  Phe Ser Gln Glu Leu  Ile Leu Gly Pro Asn  Ser            
            2820                 2825                 2830                

gag acc ccc aac  ttg tac ctg gaa cga  cag tgg gag aag cta  gag        9102
Glu Thr Pro Asn  Leu Tyr Leu Glu Arg  Gln Trp Glu Lys Leu  Glu            
            2835                 2840                 2845                

gag cag ttg gcc  acc tca gct gct caa  ctg aag ttg agc ccc  cac        9147
Glu Gln Leu Ala  Thr Ser Ala Ala Gln  Leu Lys Leu Ser Pro  His            
            2850                 2855                 2860                

ctg gcc cgg tgt  cat tcc atg gcc cag  cac gtg gcc cgc ctg  gtc        9192
Leu Ala Arg Cys  His Ser Met Ala Gln  His Val Ala Arg Leu  Val            
            2865                 2870                 2875                

cgg gtg ctg gcc  agg ccc cgg cag cat  ggc ctg ctg ctc tcg  ggg        9237
Arg Val Leu Ala  Arg Pro Arg Gln His  Gly Leu Leu Leu Ser  Gly            
            2880                 2885                 2890                

gct ctg ggt act  ggg cgc cac act gcc  atc act ctg gct tct  agc        9282
Ala Leu Gly Thr  Gly Arg His Thr Ala  Ile Thr Leu Ala Ser  Ser            
            2895                 2900                 2905                

att tgt cag gcc  cat ttc ttt cat cta  cca tct ggg tca gag  gag        9327
Ile Cys Gln Ala  His Phe Phe His Leu  Pro Ser Gly Ser Glu  Glu            
            2910                 2915                 2920                

gcc att ctc caa  tgt cta cga gat gcc  agc tgg cat gct ggc  atg        9372
Ala Ile Leu Gln  Cys Leu Arg Asp Ala  Ser Trp His Ala Gly  Met            
            2925                 2930                 2935                

tta agc cag cca  gtg gct ctg ttg gta  ccc agt ggt gtg gat  ctc        9417
Leu Ser Gln Pro  Val Ala Leu Leu Val  Pro Ser Gly Val Asp  Leu            
            2940                 2945                 2950                

act aca ctt cat  cgc ctc ctg gcc ctg  gca acc tca ggc agt  ttc        9462
Thr Thr Leu His  Arg Leu Leu Ala Leu  Ala Thr Ser Gly Ser  Phe            
            2955                 2960                 2965                

cct ggc cag tac  aca gaa gca gat ttg  gac cgc att gga gaa  cac        9507
Pro Gly Gln Tyr  Thr Glu Ala Asp Leu  Asp Arg Ile Gly Glu  His            
            2970                 2975                 2980                

ctc ccc agg gag  aac ctt ggt gtc aaa  cag aac atc aag aag  gaa        9552
Leu Pro Arg Glu  Asn Leu Gly Val Lys  Gln Asn Ile Lys Lys  Glu            
            2985                 2990                 2995                

atg gtg ttg cag  agg ttc cac cag caa  gtg tgc agc cac ctt  cac        9597
Met Val Leu Gln  Arg Phe His Gln Gln  Val Cys Ser His Leu  His            
            3000                 3005                 3010                

ctg ttc ttc ctg  att gga gat aaa cag  gcc cac aag cag ctg  ccc        9642
Leu Phe Phe Leu  Ile Gly Asp Lys Gln  Ala His Lys Gln Leu  Pro            
            3015                 3020                 3025                

tcc acc ctt ttc  ctg agg ctc ctt caa  ctg gcc act gcc agc  att        9687
Ser Thr Leu Phe  Leu Arg Leu Leu Gln  Leu Ala Thr Ala Ser  Ile            
            3030                 3035                 3040                

gac cgc tat gaa  ccc tgg gac caa gct  gcc ctg gcc aag gtg  gcc        9732
Asp Arg Tyr Glu  Pro Trp Asp Gln Ala  Ala Leu Ala Lys Val  Ala            
            3045                 3050                 3055                

cag cat cac ctg  gag ggt gct cag agt  gtg ccc ctt gat gac  ggc        9777
Gln His His Leu  Glu Gly Ala Gln Ser  Val Pro Leu Asp Asp  Gly            
            3060                 3065                 3070                

tcc tgg aag tac  cca gac ctc cag gcc  tca att ccc agt gtg  gcc        9822
Ser Trp Lys Tyr  Pro Asp Leu Gln Ala  Ser Ile Pro Ser Val  Ala            
            3075                 3080                 3085                

aaa gcc atg gct  ctt atc cac ctt tcg  gcc acc cac tac cat  gag        9867
Lys Ala Met Ala  Leu Ile His Leu Ser  Ala Thr His Tyr His  Glu            
            3090                 3095                 3100                

cac ctg tgc cct  gca ttg cca ctc gtc  acc ccc aag acc ttc  cta        9912
His Leu Cys Pro  Ala Leu Pro Leu Val  Thr Pro Lys Thr Phe  Leu            
            3105                 3110                 3115                

gac ttc ctg gac  act ttc ctg atg ctg  cag caa cag aca atc  ctg        9957
Asp Phe Leu Asp  Thr Phe Leu Met Leu  Gln Gln Gln Thr Ile  Leu            
            3120                 3125                 3130                

aag att aag aac  aag gcc cag cgg gtc  cag aat gcc ttg gag  aat       10002
Lys Ile Lys Asn  Lys Ala Gln Arg Val  Gln Asn Ala Leu Glu  Asn            
            3135                 3140                 3145                

ctg aga atg ctg  att aag gag cac ggt  acc cat gcc aat ctg  atc       10047
Leu Arg Met Leu  Ile Lys Glu His Gly  Thr His Ala Asn Leu  Ile            
            3150                 3155                 3160                

ttt gac ttg gaa  cag cag ctg aaa gac  tcc ggc aag agt ctc  agc       10092
Phe Asp Leu Glu  Gln Gln Leu Lys Asp  Ser Gly Lys Ser Leu  Ser            
            3165                 3170                 3175                

atg ttt cag cag  cag cta gag caa agc  aag ctc cta tac aag  cag       10137
Met Phe Gln Gln  Gln Leu Glu Gln Ser  Lys Leu Leu Tyr Lys  Gln            
            3180                 3185                 3190                

cag ctg gaa gag  tgt cgg cat caa gag  aac ctc att gag aac  ctg       10182
Gln Leu Glu Glu  Cys Arg His Gln Glu  Asn Leu Ile Glu Asn  Leu            
            3195                 3200                 3205                

gcc agg caa cgg  gat gcc ctg caa gct  cag cga gag gct ttc  ctg       10227
Ala Arg Gln Arg  Asp Ala Leu Gln Ala  Gln Arg Glu Ala Phe  Leu            
            3210                 3215                 3220                

gag cag atg agc  aag gca ttt ctg gag  cct ctg agc cag ctg  cag       10272
Glu Gln Met Ser  Lys Ala Phe Leu Glu  Pro Leu Ser Gln Leu  Gln            
            3225                 3230                 3235                

gtg gct gac ttt  gag gag ata cgg agc  tat cga gca cca cca  gaa       10317
Val Ala Asp Phe  Glu Glu Ile Arg Ser  Tyr Arg Ala Pro Pro  Glu            
            3240                 3245                 3250                

tct gtg gtc cgg  gta act gat gca atg  tgt gac ttg ttc cac  cat       10362
Ser Val Val Arg  Val Thr Asp Ala Met  Cys Asp Leu Phe His  His            
            3255                 3260                 3265                

gaa aca ggc tgg  gcc agt gcc aaa cag  ctg tta tgc act gag  gat       10407
Glu Thr Gly Trp  Ala Ser Ala Lys Gln  Leu Leu Cys Thr Glu  Asp            
            3270                 3275                 3280                

ttt tat cag gag  ctg gtg ttc ttc ccc  aag gag aag ata aca  gac       10452
Phe Tyr Gln Glu  Leu Val Phe Phe Pro  Lys Glu Lys Ile Thr  Asp            
            3285                 3290                 3295                

tca gag ctg ata  aag tta cat cta att  ctg aag gct cca ggt  atg       10497
Ser Glu Leu Ile  Lys Leu His Leu Ile  Leu Lys Ala Pro Gly  Met            
            3300                 3305                 3310                

gac gat gca gcc  ctg cgg gca gtg agc  cga cct gca gcc agc  ctg       10542
Asp Asp Ala Ala  Leu Arg Ala Val Ser  Arg Pro Ala Ala Ser  Leu            
            3315                 3320                 3325                

gca gcc tgg ctc  tgg gct gtt ctg cac  tat ggg ctg gcg cat  tgc       10587
Ala Ala Trp Leu  Trp Ala Val Leu His  Tyr Gly Leu Ala His  Cys            
            3330                 3335                 3340                

cgg gga ctg ccc  acg gac ctg ctg ctg  cag caa gtg gag gca  aca       10632
Arg Gly Leu Pro  Thr Asp Leu Leu Leu  Gln Gln Val Glu Ala  Thr            
            3345                 3350                 3355                

ctc act cgg gag  cag gcc cgc ctg ggc  tac tac cag ttt cag  gcc       10677
Leu Thr Arg Glu  Gln Ala Arg Leu Gly  Tyr Tyr Gln Phe Gln  Ala            
            3360                 3365                 3370                

cag gag acc ctg  gag cat aat ttg gcc  ctg gct aag atg gtg  gag       10722
Gln Glu Thr Leu  Glu His Asn Leu Ala  Leu Ala Lys Met Val  Glu            
            3375                 3380                 3385                

gat gcc caa gct  tcc cac aac tgc gtg  gca aag acc ctc agt  caa       10767
Asp Ala Gln Ala  Ser His Asn Cys Val  Ala Lys Thr Leu Ser  Gln            
            3390                 3395                 3400                

gca cag tgt ggg  cag tat cac aaa tgg  ccc atg aag gct gca  ctg       10812
Ala Gln Cys Gly  Gln Tyr His Lys Trp  Pro Met Lys Ala Ala  Leu            
            3405                 3410                 3415                

ctc acg cct atg  cgt gcc tgg act aca  cag ctc cag aag ctg  aag       10857
Leu Thr Pro Met  Arg Ala Trp Thr Thr  Gln Leu Gln Lys Leu  Lys            
            3420                 3425                 3430                

gga cgc tgc atg  act gtg ttt gga gat  acc ctc cta tgt tca  gct       10902
Gly Arg Cys Met  Thr Val Phe Gly Asp  Thr Leu Leu Cys Ser  Ala            
            3435                 3440                 3445                

gcc atc atc tac  ctg ggt ccc ttc cca  cca ttg cgg cgc caa  gag       10947
Ala Ile Ile Tyr  Leu Gly Pro Phe Pro  Pro Leu Arg Arg Gln  Glu            
            3450                 3455                 3460                

cta ctg gac gag  tgg tta gct ctg tgt  agg ggc ttt cag gag  gct       10992
Leu Leu Asp Glu  Trp Leu Ala Leu Cys  Arg Gly Phe Gln Glu  Ala            
            3465                 3470                 3475                

ctg ggc cca gat  gat gtg gca cag gca  ctg aag cgg aag caa  aaa       11037
Leu Gly Pro Asp  Asp Val Ala Gln Ala  Leu Lys Arg Lys Gln  Lys            
            3480                 3485                 3490                

tct gtc agc ata  cca cca aag aac ccc  ctg ctg gct aca cac  tct       11082
Ser Val Ser Ile  Pro Pro Lys Asn Pro  Leu Leu Ala Thr His  Ser            
            3495                 3500                 3505                

ccc ttc agt att  ctg tcc ttg ctg agc  tct gaa tcg gag cag  tac       11127
Pro Phe Ser Ile  Leu Ser Leu Leu Ser  Ser Glu Ser Glu Gln  Tyr            
            3510                 3515                 3520                

cag tgg gat gga  aac ctg aag cca cag  gca aag tcg gcc cac  ctg       11172
Gln Trp Asp Gly  Asn Leu Lys Pro Gln  Ala Lys Ser Ala His  Leu            
            3525                 3530                 3535                

gca ggc ttg ctt  ctg cga agc ccc aca  cac tac agt agt tgc  cgt       11217
Ala Gly Leu Leu  Leu Arg Ser Pro Thr  His Tyr Ser Ser Cys  Arg            
            3540                 3545                 3550                

tgg cct ctg ctg  ctt gac ccc agc aac  gag gcc ctc atc tgg  ttg       11262
Trp Pro Leu Leu  Leu Asp Pro Ser Asn  Glu Ala Leu Ile Trp  Leu            
            3555                 3560                 3565                

gac ccg ctg cct  ctg gaa gag aat cga  tct ttt gcg cca gcc  ctc       11307
Asp Pro Leu Pro  Leu Glu Glu Asn Arg  Ser Phe Ala Pro Ala  Leu            
            3570                 3575                 3580                

act gag ggt aga  ggg aaa ggc ctc atg  aga aat caa aag aga  gag       11352
Thr Glu Gly Arg  Gly Lys Gly Leu Met  Arg Asn Gln Lys Arg  Glu            
            3585                 3590                 3595                

agt aaa acg gac  atg aaa gag gaa gat  gat gag agt gaa gag  agt       11397
Ser Lys Thr Asp  Met Lys Glu Glu Asp  Asp Glu Ser Glu Glu  Ser            
            3600                 3605                 3610                

aat gag gct gag  gac cag aca aaa gag  cag aag gca gag gaa  aga       11442
Asn Glu Ala Glu  Asp Gln Thr Lys Glu  Gln Lys Ala Glu Glu  Arg            
            3615                 3620                 3625                

aaa aat gag cag  gag aaa gag caa gag  gaa aat gaa gag aaa  gag       11487
Lys Asn Glu Gln  Glu Lys Glu Gln Glu  Glu Asn Glu Glu Lys  Glu            
            3630                 3635                 3640                

gag gag aag aca  gag agc cag ggg tca  aag cca gcc tat gag  act       11532
Glu Glu Lys Thr  Glu Ser Gln Gly Ser  Lys Pro Ala Tyr Glu  Thr            
            3645                 3650                 3655                

cag ctt cca tcc  ctt ccc tac ctt agt  gtt ctt tca ggt gct  gac       11577
Gln Leu Pro Ser  Leu Pro Tyr Leu Ser  Val Leu Ser Gly Ala  Asp            
            3660                 3665                 3670                

cca gag ctg ggt  tct cag ctc cag gag  gca gct gct tgt ggc  ctg       11622
Pro Glu Leu Gly  Ser Gln Leu Gln Glu  Ala Ala Ala Cys Gly  Leu            
            3675                 3680                 3685                

cct gtg tta ctg  acc aat gtg gag ctg  ggt cta ggg tgc gaa  gaa       11667
Pro Val Leu Leu  Thr Asn Val Glu Leu  Gly Leu Gly Cys Glu  Glu            
            3690                 3695                 3700                

ctg caa tgg ctg  ctg caa cgg gag cag  ctg agt cca ccc cag  gtg       11712
Leu Gln Trp Leu  Leu Gln Arg Glu Gln  Leu Ser Pro Pro Gln  Val            
            3705                 3710                 3715                

cag cct ggc ttc  tgt ctg tat ctc agc  acc acc ctc tcc ctc  tgt       11757
Gln Pro Gly Phe  Cys Leu Tyr Leu Ser  Thr Thr Leu Ser Leu  Cys            
            3720                 3725                 3730                

gcc atg gaa aaa  gtg cta ggt tgt gaa  ctg cta aag ggg ctg  aat       11802
Ala Met Glu Lys  Val Leu Gly Cys Glu  Leu Leu Lys Gly Leu  Asn            
            3735                 3740                 3745                

gtg ttg gat ctg  ggc ctg aac atg gaa  ata ctg gaa gaa cag  atg       11847
Val Leu Asp Leu  Gly Leu Asn Met Glu  Ile Leu Glu Glu Gln  Met            
            3750                 3755                 3760                

ctg cat gaa atc  ttg tgc aga gag tat  cct gaa ctc gag acc  cgc       11892
Leu His Glu Ile  Leu Cys Arg Glu Tyr  Pro Glu Leu Glu Thr  Arg            
            3765                 3770                 3775                

tgg cag gac cta  aag atc aga gcc cta  gat acc tgc aag gct  gtg       11937
Trp Gln Asp Leu  Lys Ile Arg Ala Leu  Asp Thr Cys Lys Ala  Val            
            3780                 3785                 3790                

gag gct gct gag  gag cgg ctg ctg acg  atg ctg ctg ttc cag  aat       11982
Glu Ala Ala Glu  Glu Arg Leu Leu Thr  Met Leu Leu Phe Gln  Asn            
            3795                 3800                 3805                

ccg aag cgt cag  aag cca gcc aag ttt  ctg cgg aac ata gtg  agg       12027
Pro Lys Arg Gln  Lys Pro Ala Lys Phe  Leu Arg Asn Ile Val  Arg            
            3810                 3815                 3820                

gcc caa gga aag  cta tgc cag ctg cgt  gct cat tgt gaa gag  tta       12072
Ala Gln Gly Lys  Leu Cys Gln Leu Arg  Ala His Cys Glu Glu  Leu            
            3825                 3830                 3835                

gaa ggg cag aaa  cta cag gag atg gta  ttg tgg gca ccc tat  cga       12117
Glu Gly Gln Lys  Leu Gln Glu Met Val  Leu Trp Ala Pro Tyr  Arg            
            3840                 3845                 3850                

cct gtg gtt tgg  cat gga atg gcc atg  gta aag gcc cta agc  caa       12162
Pro Val Val Trp  His Gly Met Ala Met  Val Lys Ala Leu Ser  Gln            
            3855                 3860                 3865                

ctg cag aac ctg  ctg cca ctt ttc tgt  atg agc cca gag aac  tgg       12207
Leu Gln Asn Leu  Leu Pro Leu Phe Cys  Met Ser Pro Glu Asn  Trp            
            3870                 3875                 3880                

ctg gca gtc act  aag cag gct ctg gac  agc atg aag cca cgt  gag       12252
Leu Ala Val Thr  Lys Gln Ala Leu Asp  Ser Met Lys Pro Arg  Glu            
            3885                 3890                 3895                

att aat cac ggg  gag gac ctg gcc agc  cat cta ctg caa ttg  aga       12297
Ile Asn His Gly  Glu Asp Leu Ala Ser  His Leu Leu Gln Leu  Arg            
            3900                 3905                 3910                

gca cac ctg acc  cgc cag ctg ctg ggc  agc acc gtg act gca  ctg       12342
Ala His Leu Thr  Arg Gln Leu Leu Gly  Ser Thr Val Thr Ala  Leu            
            3915                 3920                 3925                

ggc ctt acc caa  gta ccc ttg gtg ggt  gca ttg ggc gct ttg  gct       12387
Gly Leu Thr Gln  Val Pro Leu Val Gly  Ala Leu Gly Ala Leu  Ala            
            3930                 3935                 3940                

ctg ctg caa gca  aca ggg aaa gca tca  gag ctg gaa aga ctg  gca       12432
Leu Leu Gln Ala  Thr Gly Lys Ala Ser  Glu Leu Glu Arg Leu  Ala            
            3945                 3950                 3955                

ctc tgg cct gga  cta gca gcc tct ccc  agc aca gtc cac agc  aag       12477
Leu Trp Pro Gly  Leu Ala Ala Ser Pro  Ser Thr Val His Ser  Lys            
            3960                 3965                 3970                

cca gtc tca gat  gtg gct cga ccg gcc  tgg ctt ggg cca aaa  gcc       12522
Pro Val Ser Asp  Val Ala Arg Pro Ala  Trp Leu Gly Pro Lys  Ala            
            3975                 3980                 3985                

tgg cat gaa tgt  gag atg tta gag ctg  ctg ccc cca ttt gtt  ggc       12567
Trp His Glu Cys  Glu Met Leu Glu Leu  Leu Pro Pro Phe Val  Gly            
            3990                 3995                 4000                

ctg tgt gcc tcc  ctg gca ggc cac tcc  agt gct tgg cag gct  tac       12612
Leu Cys Ala Ser  Leu Ala Gly His Ser  Ser Ala Trp Gln Ala  Tyr            
            4005                 4010                 4015                

ctg tca ctg tca  tcc aca gtg ctg ggt  cct gca cct ggg cca  ggg       12657
Leu Ser Leu Ser  Ser Thr Val Leu Gly  Pro Ala Pro Gly Pro  Gly            
            4020                 4025                 4030                

cct gag cca ctc  agc ctc ctc cag aag  ctg atc ctg tgg cgc  gtt       12702
Pro Glu Pro Leu  Ser Leu Leu Gln Lys  Leu Ile Leu Trp Arg  Val            
            4035                 4040                 4045                

ctg cga cct gag  tgc ctg gca ggt gcc  ctg gca gac ttc acc  act       12747
Leu Arg Pro Glu  Cys Leu Ala Gly Ala  Leu Ala Asp Phe Thr  Thr            
            4050                 4055                 4060                

agc ctc ctg ggt  cgg ccc ctg gat gaa  aac acg tat gct ccc  acc       12792
Ser Leu Leu Gly  Arg Pro Leu Asp Glu  Asn Thr Tyr Ala Pro  Thr            
            4065                 4070                 4075                

atg ccc ttt aaa  cat agt cag gct act  cag ccc atg ctg atc  ttg       12837
Met Pro Phe Lys  His Ser Gln Ala Thr  Gln Pro Met Leu Ile  Leu            
            4080                 4085                 4090                

ttg cca ccg cct  ggc cac ccc tca gcc  act ctg cat cct ctg  act       12882
Leu Pro Pro Pro  Gly His Pro Ser Ala  Thr Leu His Pro Leu  Thr            
            4095                 4100                 4105                

gtc atc cag aaa  ctg gct gcc aag tat  cag cag ggg cag aag  caa       12927
Val Ile Gln Lys  Leu Ala Ala Lys Tyr  Gln Gln Gly Gln Lys  Gln            
            4110                 4115                 4120                

ctg cag gtg ata  gcc ctg ggc tct gaa  gcc tgg gac cca gtc  tca       12972
Leu Gln Val Ile  Ala Leu Gly Ser Glu  Ala Trp Asp Pro Val  Ser            
            4125                 4130                 4135                

gtt gtg gtc agc  act cta tcc cag gct  atg tat gag ggg cac  tgg       13017
Val Val Val Ser  Thr Leu Ser Gln Ala  Met Tyr Glu Gly His  Trp            
            4140                 4145                 4150                

ctg gtg ctg gac  aac tgt cat ctg atg  ccc cat tgg ccg aaa  gag       13062
Leu Val Leu Asp  Asn Cys His Leu Met  Pro His Trp Pro Lys  Glu            
            4155                 4160                 4165                

ctg cta cag ctc  ttg ctg gaa ctg tta  ggc aga gcc aag gtg  gtt       13107
Leu Leu Gln Leu  Leu Leu Glu Leu Leu  Gly Arg Ala Lys Val  Val            
            4170                 4175                 4180                

gca gac ctg gaa  tca gaa cag ctt tta  gac caa cct gaa agc  agg       13152
Ala Asp Leu Glu  Ser Glu Gln Leu Leu  Asp Gln Pro Glu Ser  Arg            
            4185                 4190                 4195                

aat gta agc act  gtt cac aga gat ttt  cgt ctt tgg ctt att  gtg       13197
Asn Val Ser Thr  Val His Arg Asp Phe  Arg Leu Trp Leu Ile  Val            
            4200                 4205                 4210                

cct gca gag tct  agt gct tct ttg cca  gct gtg ctg act cag  cac       13242
Pro Ala Glu Ser  Ser Ala Ser Leu Pro  Ala Val Leu Thr Gln  His            
            4215                 4220                 4225                

tcc atg cct gtt  ttc tgg aac cag tcc  ctg gag ctg ggc cat  gtt       13287
Ser Met Pro Val  Phe Trp Asn Gln Ser  Leu Glu Leu Gly His  Val            
            4230                 4235                 4240                

ttg att gac agt  gtg gag cta gcc cag  caa gta ctc tac atg  caa       13332
Leu Ile Asp Ser  Val Glu Leu Ala Gln  Gln Val Leu Tyr Met  Gln            
            4245                 4250                 4255                

ccc ccc acc cag  gca cta cct ctg ctc  ctc ctc cat ggc ctc  ctg       13377
Pro Pro Thr Gln  Ala Leu Pro Leu Leu  Leu Leu His Gly Leu  Leu            
            4260                 4265                 4270                

cta cac cgg cag  ctc tat gga aca agg  ctg cag gca cac agg  ggg       13422
Leu His Arg Gln  Leu Tyr Gly Thr Arg  Leu Gln Ala His Arg  Gly            
            4275                 4280                 4285                

cgc tgg agt caa  gtg act cta acc cag  gtt ctt cag acc caa  gac       13467
Arg Trp Ser Gln  Val Thr Leu Thr Gln  Val Leu Gln Thr Gln  Asp            
            4290                 4295                 4300                

cag ctg tgg gca  agt ctt agc aat ccc  cgt gct gcc atg caa  gag       13512
Gln Leu Trp Ala  Ser Leu Ser Asn Pro  Arg Ala Ala Met Gln  Glu            
            4305                 4310                 4315                

ctg gct gct tca  gtt ttc tac ggg ggt  cct ctg ggg gac act  gag       13557
Leu Ala Ala Ser  Val Phe Tyr Gly Gly  Pro Leu Gly Asp Thr  Glu            
            4320                 4325                 4330                

gac agg gag gcc  ctg att agc ctc aca  caa gcc tgc ctg agc  ccc       13602
Asp Arg Glu Ala  Leu Ile Ser Leu Thr  Gln Ala Cys Leu Ser  Pro            
            4335                 4340                 4345                

agt agt ggg agc  tgg gtc cag cca cac  aca cct cag tct ttg  ctg       13647
Ser Ser Gly Ser  Trp Val Gln Pro His  Thr Pro Gln Ser Leu  Leu            
            4350                 4355                 4360                

gcc acg ctc atg  ccc ctc cca gag cta  agg gag ctg gat gca  atg       13692
Ala Thr Leu Met  Pro Leu Pro Glu Leu  Arg Glu Leu Asp Ala  Met            
            4365                 4370                 4375                

gca gag tgc aag  gcc cag atg cac cta  ctg ccc tca cca cct  gaa       13737
Ala Glu Cys Lys  Ala Gln Met His Leu  Leu Pro Ser Pro Pro  Glu            
            4380                 4385                 4390                

ccc cgg ctc tgc  gga ctg agt gag ggc  ccc caa gcc tgg ctg  ttg       13782
Pro Arg Leu Cys  Gly Leu Ser Glu Gly  Pro Gln Ala Trp Leu  Leu            
            4395                 4400                 4405                

cga cgc cag agt  cgc gct ctc ttg agt  gcg ctg cag cgg agt  tca       13827
Arg Arg Gln Ser  Arg Ala Leu Leu Ser  Ala Leu Gln Arg Ser  Ser            
            4410                 4415                 4420                

ccc gtg tgg gtt  cct gag tct cga aga  ggc gcc cag ctt gcg  gaa       13872
Pro Val Trp Val  Pro Glu Ser Arg Arg  Gly Ala Gln Leu Ala  Glu            
            4425                 4430                 4435                

agg cga ctg cgg  caa cgc cta gtg caa  gtc aac cgg agg ctg  gag       13917
Arg Arg Leu Arg  Gln Arg Leu Val Gln  Val Asn Arg Arg Leu  Glu            
            4440                 4445                 4450                

tca ctg cag gat  ctg ctg acc cac gtg  att cgc caa gac gag  tcc       13962
Ser Leu Gln Asp  Leu Leu Thr His Val  Ile Arg Gln Asp Glu  Ser            
            4455                 4460                 4465                

gac gcc ccg tgg  tca gtg ctg ggg cca  aat gca cgg cgg cct  ctg       14007
Asp Ala Pro Trp  Ser Val Leu Gly Pro  Asn Ala Arg Arg Pro  Leu            
            4470                 4475                 4480                

gag ggc gtc tta  gag acc gag gct cta  gaa ctg agc cag ttg  gtg       14052
Glu Gly Val Leu  Glu Thr Glu Ala Leu  Glu Leu Ser Gln Leu  Val            
            4485                 4490                 4495                

ggc acg cta caa  cgc gac ctt gat tgc  ctg ttg cag cag ctg  aag       14097
Gly Thr Leu Gln  Arg Asp Leu Asp Cys  Leu Leu Gln Gln Leu  Lys            
            4500                 4505                 4510                

ggc gca ccc ccg  tgc ccc tcc cgc cgc  tgt gct gcg gtg gcc  cac       14142
Gly Ala Pro Pro  Cys Pro Ser Arg Arg  Cys Ala Ala Val Ala  His            
            4515                 4520                 4525                

gct ctc tgg act  ggc cgc cta ccc ttg  cct tgg cga cct cat  gcg       14187
Ala Leu Trp Thr  Gly Arg Leu Pro Leu  Pro Trp Arg Pro His  Ala            
            4530                 4535                 4540                

ccg gcc ggt ccg  cag ccg ccc tgg cac  tgg ctg cga cag ttg  tcg       14232
Pro Ala Gly Pro  Gln Pro Pro Trp His  Trp Leu Arg Gln Leu  Ser            
            4545                 4550                 4555                

cgc cgt ggg caa  ctg ttg gtt cgt tac  ttg ggc gtg ggc gcg  gac       14277
Arg Arg Gly Gln  Leu Leu Val Arg Tyr  Leu Gly Val Gly Ala  Asp            
            4560                 4565                 4570                

gcg agc agt gat  gta cca gag cgc gtc  ttc cac ctg tca gcc  ttt       14322
Ala Ser Ser Asp  Val Pro Glu Arg Val  Phe His Leu Ser Ala  Phe            
            4575                 4580                 4585                

cgc cac ccg cgc  cgc ctg ctg ctg gca  ttg cgt ggg gaa gct  gcc       14367
Arg His Pro Arg  Arg Leu Leu Leu Ala  Leu Arg Gly Glu Ala  Ala            
            4590                 4595                 4600                

ctg gac cag aat  gtg ccc agc tcg aat  ttc cct ggt agc cga  ggc       14412
Leu Asp Gln Asn  Val Pro Ser Ser Asn  Phe Pro Gly Ser Arg  Gly            
            4605                 4610                 4615                

tcg gtc tcc agt  cag ctc cag tat aaa  cgt ctg gag atg aac  agc       14457
Ser Val Ser Ser  Gln Leu Gln Tyr Lys  Arg Leu Glu Met Asn  Ser            
            4620                 4625                 4630                

aac cct ctg cac  ttc agg gtg gag aat  ggt cca aat ccc acg  gtt       14502
Asn Pro Leu His  Phe Arg Val Glu Asn  Gly Pro Asn Pro Thr  Val            
            4635                 4640                 4645                

cca gag aga ggg  ctg ctg ctg atc ggg  cta cag gtc cta cat  gcg       14547
Pro Glu Arg Gly  Leu Leu Leu Ile Gly  Leu Gln Val Leu His  Ala            
            4650                 4655                 4660                

gag tgg gac cca  ata gct gga gcc ttg  cag gac agt cct tcc  agc       14592
Glu Trp Asp Pro  Ile Ala Gly Ala Leu  Gln Asp Ser Pro Ser  Ser            
            4665                 4670                 4675                

caa ccc agc cct  ctg cct ccc gtc agc  atc agc aca cag gcc  ccg       14637
Gln Pro Ser Pro  Leu Pro Pro Val Ser  Ile Ser Thr Gln Ala  Pro            
            4680                 4685                 4690                

ggc acc agt gac  ctg cca gcc cca gcc  gac ctg act gtg tac  tcg       14682
Gly Thr Ser Asp  Leu Pro Ala Pro Ala  Asp Leu Thr Val Tyr  Ser            
            4695                 4700                 4705                

tgt cct gtg tac  atg gga ggg ccc ctt  ggc acc gct aag ctg  cag       14727
Cys Pro Val Tyr  Met Gly Gly Pro Leu  Gly Thr Ala Lys Leu  Gln            
            4710                 4715                 4720                

agc agg aac atc  gtg atg cat ctg cct  tta ccc acc aag ctc  acc       14772
Ser Arg Asn Ile  Val Met His Leu Pro  Leu Pro Thr Lys Leu  Thr            
            4725                 4730                 4735                

ccc aac acc tgt  gtc caa agg agg gtc  cat gtg tgc agc cca  ccc       14817
Pro Asn Thr Cys  Val Gln Arg Arg Val  His Val Cys Ser Pro  Pro            
            4740                 4745                 4750                

ctg tct tga gcccgtctac caaaataaag ttgtagtgat tccatgaaaa              14866
Leu Ser                                                                   
                                                                          

aaaaaaaaaa aaaaaa                                                    14882


<210>  710
<211>  4753
<212>  PRT
<213>  Homo sapiens

<400>  710

Met Val Pro Glu Glu Arg Arg Val Gly Leu Ser Ser Asp Glu Thr Ser 
1               5                   10                  15      


Ser Asp Ser Leu Lys Ser Trp His Ser Ile Cys Val Leu Asp Ser Lys 
            20                  25                  30          


Glu Gln Pro Leu Ala Cys Gln Gln Lys Gln Arg Gln Phe Val Lys Pro 
        35                  40                  45              


Val Thr Glu Ser Glu Gln Pro Thr Val Leu Glu Leu Leu Leu Ala Glu 
    50                  55                  60                  


Leu Arg Thr Leu Phe Ser Ala Val Leu Gln Asp Ser Ser Pro Ala Ala 
65                  70                  75                  80  


Trp Arg Tyr Leu His Ala Val Leu Gly Leu Leu Pro Pro Tyr Arg Glu 
                85                  90                  95      


Leu Leu Val Gly His Leu Asp Leu Leu Pro Phe Leu Glu Gln Leu Tyr 
            100                 105                 110         


Cys Trp Ala Pro Trp Val Gln Thr His Leu His Leu Asp Leu Leu Gly 
        115                 120                 125             


Ala Ile Val Gln Ala Phe Pro Pro Asp Ser Ser Leu Leu Asp Ser Ala 
    130                 135                 140                 


Ser His Ala Asp Cys Cys Pro Gln Lys Arg Arg Leu His His Arg Pro 
145                 150                 155                 160 


Pro Cys Pro Ala Cys Pro Phe Val Gln Ala Gln Trp Ser Arg Gln Gln 
                165                 170                 175     


Val Lys Glu Glu Leu Ala Thr Trp Leu Arg Pro Leu Thr Leu Pro Glu 
            180                 185                 190         


Leu Gln Arg Cys Leu Gly Ile Val Gly Ala Gln Val Ala Leu Glu Glu 
        195                 200                 205             


Ala Val Trp Leu Asp Gly Leu Ser Leu Leu Pro Leu Ala Leu Ala Ala 
    210                 215                 220                 


Asp Ile Pro Val Arg Tyr Glu Ser Ser Asp Thr Asp Asn Ala Glu Val 
225                 230                 235                 240 


Glu Pro Val Gly Arg Lys Glu Thr Arg Ser Gln Leu Asp Tyr Glu Val 
                245                 250                 255     


Pro Arg Glu Lys Ala Phe Gln Lys Ser Ser Thr Gly Phe Ser Pro Glu 
            260                 265                 270         


Thr Ser Phe Leu Asp Ser Gln Val Met Thr Ala Leu Lys Met Glu Arg 
        275                 280                 285             


Tyr Leu Lys Lys Ile His Phe Leu Tyr Leu Asn Val Ala Pro Ser Arg 
    290                 295                 300                 


Tyr Phe Arg Pro Tyr Ser Leu Met Val Val Pro Pro Asp Lys Val Asn 
305                 310                 315                 320 


Pro Glu His Tyr Ile Phe Ser Pro Phe Gly Ile Leu His Val His Pro 
                325                 330                 335     


Val Glu Gly Ser Glu Thr Met Thr Leu Gly Thr Trp His His His Cys 
            340                 345                 350         


Val Leu Trp Gln Gln Leu Gln Phe Ile Pro Phe Phe Lys Tyr Cys Leu 
        355                 360                 365             


Leu Arg Lys Ser Phe Thr Cys Trp Lys Lys Asn Val Arg Leu Gln Gly 
    370                 375                 380                 


Leu His Arg Leu Gln Lys Phe Leu Glu Asn His Leu Leu Leu Ala Val 
385                 390                 395                 400 


Pro His Phe Gly Ala Gly Leu Leu His Ile Ser Arg Leu Leu Gln Glu 
                405                 410                 415     


Leu His Ser Val Ser Trp Leu Pro Gln Glu Leu Asp Arg Cys Tyr Glu 
            420                 425                 430         


Leu Leu Asp Leu Gln Thr Ala Leu Ala Glu Glu Lys His Lys Ala Leu 
        435                 440                 445             


Arg Leu Leu His Arg Cys Leu Asn Leu Cys Thr Ser Ile Leu Arg Leu 
    450                 455                 460                 


Val His Glu Asp Thr Tyr His Met Gln Gln Cys Leu Gln Glu Arg Val 
465                 470                 475                 480 


Gln Asn Cys Asp Arg Ile Arg Thr Gly Gln Gly Ser Ile Tyr Leu Gln 
                485                 490                 495     


Arg Val Gln His Lys Gln Leu Glu Gln Lys Leu Lys Gln Ala Glu Ala 
            500                 505                 510         


Trp Trp Leu Gln Leu Gly Lys Phe Ala Arg Leu Val Asp Tyr Met Ile 
        515                 520                 525             


Cys Gln Ser Leu Ile Ser Val Leu Glu Glu Gln Ile Thr Ser Phe Val 
    530                 535                 540                 


Ala Asn Ile Leu Gln Ala Pro Arg Gln Lys Pro Phe Leu Ser Ser Gln 
545                 550                 555                 560 


Leu Val Phe Asp Asp His Gly Gln Leu Ser His Val Pro Cys Val Glu 
                565                 570                 575     


Asn Met Ile Gln Thr Leu Thr Gly Gly Leu Gln Ser Val Lys Thr Ser 
            580                 585                 590         


Ala Leu Gln Val Val Gln Ser Ala Asp Leu Lys Thr Ser Ser Asp Ser 
        595                 600                 605             


Leu Tyr Ser Glu Glu Glu Asp Glu Glu Glu Asp Ser Lys Asp Glu Phe 
    610                 615                 620                 


Leu Met Pro Lys Phe Gln Gly Gln Pro Ser Asp Ala Val Ser Ile Phe 
625                 630                 635                 640 


Cys Gly Pro Asn Val Gly Leu Val Trp Pro Trp Lys Ser His Pro Ile 
                645                 650                 655     


Ala Gly Ile Leu Glu Val Arg Gly Cys Arg Leu Arg Gly Gln Tyr Phe 
            660                 665                 670         


Pro His Asn Tyr Lys Gln Leu Glu Glu Asp Leu Asp Asn Asn Pro Lys 
        675                 680                 685             


Ile Gln Gln Ala Leu Asn Ile Gln Gln Val Leu Leu Glu Gly Val Leu 
    690                 695                 700                 


Cys Lys Val Gln Glu Phe Cys Arg Glu His His Trp Ile Thr Gly Ile 
705                 710                 715                 720 


Tyr Glu Phe Leu Gln Ser Trp Gly Pro Gln Lys Leu Glu Asp Met Arg 
                725                 730                 735     


Gly Gly Pro Ile Lys Asn Tyr Val Thr Leu Val Ser Arg Leu Asn Val 
            740                 745                 750         


Trp Gln Ala Arg Val Ser Ser Met Pro Ile Glu Leu Leu Thr Lys Gly 
        755                 760                 765             


Gly Leu Leu Leu Leu Ser Cys His Asp Val Gln Ala Glu Met Glu Ser 
    770                 775                 780                 


Lys Leu Asn Ser Ile Arg Lys Asp Ile Leu Ala His Val Gln Asn Glu 
785                 790                 795                 800 


Cys Trp Asn Leu Ser Gln Gln Leu Met Thr Glu Leu Thr Asp Phe Met 
                805                 810                 815     


His Ile Phe Arg Thr Ile Asn Ser Asp Ile His Ala Ile Ala Gln Cys 
            820                 825                 830         


Thr Gln Lys Leu Asn Glu Ala Asn Glu Gln Tyr Val Glu Leu Glu Glu 
        835                 840                 845             


Arg Met Glu Tyr Val Arg Ala Leu His Glu Leu Ile Arg Asn His Phe 
    850                 855                 860                 


Ser Leu Phe Ser Ala Glu Asn Glu Ala Leu Asp Ile Ser Val Arg Arg 
865                 870                 875                 880 


Gln Phe Gly Glu Ser Pro Ile Pro Pro Cys Pro Pro Pro Pro Gln Pro 
                885                 890                 895     


His Leu Leu His Cys Pro Leu Leu Ala Pro Gln Leu Leu Asp Met Trp 
            900                 905                 910         


Glu Ala Phe Gln Phe Glu Lys Ser Gln Ala Ser Glu Phe Leu Leu Ser 
        915                 920                 925             


Lys Arg His Ala Ile Met Pro Lys Leu Gln Gln Leu Met Ala Ala Ala 
    930                 935                 940                 


Leu Ala Glu Leu Glu Gly Leu Leu Ala Lys Ala Leu Ser Gly Pro Phe 
945                 950                 955                 960 


Met Asp Pro Thr Gln Asp Gln Arg Ser Thr Glu His Gln Leu Val Ser 
                965                 970                 975     


Leu Glu Arg Gln Phe Gln Asn Thr Val Ser Asp Leu Ser Glu Leu His 
            980                 985                 990         


His Ala Tyr Ala Ile Phe Thr Glu  Asp Glu Thr Pro Val  Pro Leu Pro 
        995                 1000                 1005             


Ile Cys  Gly Thr Arg Pro Ile  Val Gln Gln Gln Arg  Ile Trp His 
    1010                 1015                 1020             


Leu Tyr  Arg Val Ile Ser Glu  Asn Ile Ser Glu Trp  Lys Cys Met 
    1025                 1030                 1035             


Ala Phe  Ala Lys Phe Ser Pro  Ala Met Ala Gln Glu  Lys Thr Glu 
    1040                 1045                 1050             


Gly Trp  Leu Thr Glu Ala Ala  Arg Met Ser Thr Thr  Leu Glu Leu 
    1055                 1060                 1065             


His Ser  Pro Val Leu Gln His  Cys Met Arg Ile Leu  Gly Glu Phe 
    1070                 1075                 1080             


Arg Ser  Tyr Leu Pro Leu Leu  Thr Lys Leu Gly Ser  Leu His Pro 
    1085                 1090                 1095             


Gln Ser  Leu Asn Cys Gln Cys  Leu Leu Arg Ala Leu  Gly Leu Gly 
    1100                 1105                 1110             


Ser Leu  Gln Thr Ile Glu Leu  Leu Thr Leu Gly Gln  Leu Leu Thr 
    1115                 1120                 1125             


Tyr Pro  Leu Leu Glu Phe Ala  Asp Arg Ile Asn Gln  Val Trp Gln 
    1130                 1135                 1140             


Asn Glu  Asn Glu Arg Ile His  Ala Gln Glu Thr Ile  Arg Arg Leu 
    1145                 1150                 1155             


Gln Arg  Tyr Trp Glu Ala Arg  Gln Leu Arg Leu Leu  Asn Phe Ile 
    1160                 1165                 1170             


Leu His  Val Pro Tyr Glu Pro  Pro Ala Ser Glu Arg  Ser Lys Arg 
    1175                 1180                 1185             


Gln Val  Leu Arg Ser Pro Gln  Trp Glu Val Val Asp  Lys Asp Ser 
    1190                 1195                 1200             


Gly Thr  Phe Ile Leu Ser Asp  Tyr Ser Asn Leu Gln  Asp Ser Ile 
    1205                 1210                 1215             


Gln Glu  Ser Leu Gln Val Leu  Ser Lys Ile Leu Ala  Ile Glu Lys 
    1220                 1225                 1230             


Ser Gly  Asp Leu Asn Lys Ile  Ala Leu Glu Trp Val  Ala Ile Met 
    1235                 1240                 1245             


His Gly  Leu Gly Ala Leu Leu  Glu Val Trp Leu Thr  Phe Gln Gln 
    1250                 1255                 1260             


Lys Trp  Ile Phe Leu Asn Lys  Val Leu His Glu Met  Lys Ile Gln 
    1265                 1270                 1275             


Phe Pro  Asn Ala Asp Leu Asn  Ser Arg Phe Lys Val  Met Asp Asp 
    1280                 1285                 1290             


Gln Tyr  Arg Thr Leu Met Arg  Ile Ser Val Ala Asp  Pro Met Val 
    1295                 1300                 1305             


Leu Ser  Leu Val Val Pro Ser  Ala Glu Arg Ser Pro  Tyr Phe Gln 
    1310                 1315                 1320             


Gly Gln  Gln Leu Gln Gln Leu  Leu Gln Ala Gly Ser  Val Glu Leu 
    1325                 1330                 1335             


Glu Gly  Ile Ile Met Ser Leu  Glu Ser Val Leu Tyr  Gly Val Cys 
    1340                 1345                 1350             


Ala His  Phe Pro Arg Leu Phe  Phe Leu Ser Asp Ser  Glu Leu Val 
    1355                 1360                 1365             


Ala Leu  Leu Ala Ala Arg Leu  Glu Ser Cys Glu Ala  Gln Leu Trp 
    1370                 1375                 1380             


Val Arg  Arg Cys Phe Pro His  Val His Ala Val Ser  Phe Arg Ser 
    1385                 1390                 1395             


Cys Pro  Thr Gly Glu Lys Asn  Thr Asp Asp Trp Glu  Ser Ser Pro 
    1400                 1405                 1410             


Asn Thr  Gln Thr Gln Val Glu  Ala Leu Ala Val Leu  Gly Ala Gly 
    1415                 1420                 1425             


Gly Glu  Glu Val Lys Leu Gln  Gly Pro Leu Pro Leu  His Pro Asp 
    1430                 1435                 1440             


Leu Pro  Lys Trp Leu Ala Ser  Leu Glu Lys Cys Leu  Arg Leu Ala 
    1445                 1450                 1455             


Leu Val  His Met Leu Gln Gly  Cys Val Ala Ala Arg  Leu Ala Arg 
    1460                 1465                 1470             


Gly Pro  Ser Leu Gly Glu Ala  Leu Lys Gln Leu Pro  Lys Gln Asn 
    1475                 1480                 1485             


Lys Leu  Tyr Leu Gln Leu Tyr  Val Gln His Trp Ile  Asp Leu Val 
    1490                 1495                 1500             


Gln Ala  Phe Pro Trp Gln Cys  Val Leu Val Ala Glu  Glu Val Val 
    1505                 1510                 1515             


Trp Arg  Ala Glu Met Glu Glu  Ala Leu Leu Glu Trp  Gly Thr Leu 
    1520                 1525                 1530             


Ala Met  Val Ser Met His Met  Arg Lys Leu Glu Val  Leu Val Asn 
    1535                 1540                 1545             


Phe Met  Arg Ala Gln Arg Ala  Ser Gln Gly Gly Gln  Ser Leu Pro 
    1550                 1555                 1560             


Ser Val  Arg Gln Thr Ser Leu  Leu Ser Ala Leu Leu  Val Met Ala 
    1565                 1570                 1575             


Val Thr  His Arg Asp Ile Ala  Gln Leu Leu Glu Gln  His Gln Val 
    1580                 1585                 1590             


Ser Asp  Leu Thr Asp Phe His  Trp Val Arg Gln Leu  Lys Tyr His 
    1595                 1600                 1605             


Leu Gly  Ser Pro His Ile Ile  Pro Lys Ser Pro Leu  Gln Ser Leu 
    1610                 1615                 1620             


Lys Thr  Ile Ala Ser Ser Glu  Pro Ser Leu Ser Pro  Ala Ala Cys 
    1625                 1630                 1635             


Trp Ile  Asp Val Leu Gly Arg  Ser Phe Leu Tyr Asn  Tyr Glu Tyr 
    1640                 1645                 1650             


Leu Gly  Pro Arg Leu Gly Pro  Leu Pro Ser Leu Leu  Pro Glu Arg 
    1655                 1660                 1665             


Pro Ala  Leu Val Leu Leu Leu  Ala Leu Glu Glu Val  Ala Cys Gly 
    1670                 1675                 1680             


Thr Val  Leu Gly Pro Asn Gly  Val Gly Lys Arg Ala  Ile Val Asn 
    1685                 1690                 1695             


Ser Leu  Ala Gln Ala Leu Gly  Arg Gln Leu Val Met  Leu Pro Cys 
    1700                 1705                 1710             


Ser Pro  Gln Ile Glu Ala Gln  Cys Leu Ser Asn Tyr  Leu Asn Gly 
    1715                 1720                 1725             


Ala Leu  Gln Gly Gly Ala Trp  Leu Leu Leu Glu Lys  Val His Gln 
    1730                 1735                 1740             


Leu Pro  Pro Gly Leu Leu Ser  Ala Leu Gly Gln Arg  Leu Gly Glu 
    1745                 1750                 1755             


Leu His  His Leu Tyr Ala Pro  Leu Tyr Gln Glu Ala  Ser Arg Asn 
    1760                 1765                 1770             


Thr Ser  Thr Ile Asp Pro Thr  Gln Pro Gln Leu Leu  Gly Ser Ser 
    1775                 1780                 1785             


Phe Phe  Glu Lys His His Val  Ser Val Arg Leu Gly  Tyr Gly Cys 
    1790                 1795                 1800             


Leu Leu  Val Leu Arg Ala Leu  Ser Ser Ala Val Pro  Ala Asn Leu 
    1805                 1810                 1815             


His Leu  Leu Leu Arg Pro Val  Ala Leu Ala Leu Pro  Asp Leu Arg 
    1820                 1825                 1830             


Gln Val  Ala Glu Leu Thr Leu  Leu Gly Ala Gly Met  Arg Asp Ala 
    1835                 1840                 1845             


Phe Gln  Met Ala Thr Arg Leu  Ser Lys Phe Phe Ser  Leu Glu Arg 
    1850                 1855                 1860             


Glu Leu  Val Ser Gly Pro Leu  Pro Cys Arg Leu Pro  Leu Leu Lys 
    1865                 1870                 1875             


Gln Ile  Leu Glu Asp Thr Ile  Arg Thr Leu Asn Val  Thr Lys Glu 
    1880                 1885                 1890             


Glu Pro  Lys Cys Gln Lys Pro  Arg Ser Leu Ala Ala  Ile Glu Glu 
    1895                 1900                 1905             


Ala Ala  Leu Leu Arg Ser Pro  Leu Phe Ser Ile Leu  Asn Gly Leu 
    1910                 1915                 1920             


His Leu  His Asn Leu Arg Gly  Leu Leu Cys Ala Leu  Phe Pro Ser 
    1925                 1930                 1935             


Ala Ser  Gln Val Leu Ala Glu  Pro Met Thr Tyr Lys  Leu Met Lys 
    1940                 1945                 1950             


Pro Leu  Val Val Glu Glu Leu  Gln Gln Val Gly Leu  Asp Pro Ser 
    1955                 1960                 1965             


Pro Asp  Ile Leu Gly Ser Leu  Glu Gln Leu Ser Gln  Ala Leu Ser 
    1970                 1975                 1980             


Arg Ala  Ser Gly Ile Leu Leu  Leu Gly Pro Ala Gly  Ser Gly Lys 
    1985                 1990                 1995             


Thr Thr  Cys Trp His Ser Leu  Phe Lys Ile Gln Asn  Arg Leu Ala 
    2000                 2005                 2010             


Ala Met  Glu Asp Thr Ser Thr  Gln Gly Cys Gln Pro  Val Glu Ile 
    2015                 2020                 2025             


Thr His  Leu Tyr Pro Ser Gly  Leu Ser Pro Gln Glu  Phe Leu Gly 
    2030                 2035                 2040             


Trp Leu  Glu Gly Ser Cys Trp  His His Gly Ile Phe  Pro Lys Val 
    2045                 2050                 2055             


Leu Arg  Ala Ala Gly Gln Cys  Asn Asn Met Gly Gln  Lys Arg Gln 
    2060                 2065                 2070             


Thr Glu  Glu Ser Ile Gly Ile  Gln His Trp Ile Ile  Cys Asp Gly 
    2075                 2080                 2085             


Ala Ser  Asn Gly Ala Trp Leu  Asp Ser Ile Thr Cys  Leu Leu Ser 
    2090                 2095                 2100             


Glu Leu  Pro Gln Leu Ser Leu  Pro Ser Gly Gln Gln  Ile Ala Arg 
    2105                 2110                 2115             


Pro Pro  Gly Thr Phe Leu Leu  Met Glu Val Ala Asp  Thr Thr Gly 
    2120                 2125                 2130             


Ile Ser  Pro Thr Val Val Gly  Cys Cys Ala Leu Val  Trp Cys Gly 
    2135                 2140                 2145             


Gly Glu  Gln Thr Trp Gln Cys  Ile Leu Ser Ala Leu  Met Ala Ser 
    2150                 2155                 2160             


Leu Pro  Tyr Glu Tyr Arg Leu  Gln His Arg Thr Val  Ala Glu Leu 
    2165                 2170                 2175             


Asn His  Met Ala Glu Val Leu  Val Pro Ala Thr Leu  Arg Phe Leu 
    2180                 2185                 2190             


Thr Cys  Gln Gly Val Ser Ser  Leu Leu Gln Val His  Gly Gln Gln 
    2195                 2200                 2205             


Ala Val  Cys Ala Gly Val Ala  Glu Val Thr Ser Met  Ala Arg Ile 
    2210                 2215                 2220             


Leu His  Ser Leu Leu Asp Leu  His Leu Arg Leu Lys  Glu Glu Lys 
    2225                 2230                 2235             


Ala Pro  Gly Pro Glu Asp Leu  Ser Tyr Ser Asp Pro  Val Ala Gln 
    2240                 2245                 2250             


Ser Phe  Arg Ser Ser Lys Ser  Ser Phe Leu Asn Arg  Ser Gln Val 
    2255                 2260                 2265             


Asp Ser  Asp Asp Val Pro Asp  Lys Cys Arg Glu His  Leu Leu Ala 
    2270                 2275                 2280             


Val Ser  Ser Phe Leu Phe Ala  Leu Ile Trp Gly Phe  Gly Ala His 
    2285                 2290                 2295             


Leu Pro  Ser Arg Phe Trp Pro  Ile Phe Asp Thr Phe  Ile Arg Asp 
    2300                 2305                 2310             


Ser Ile  Ser Arg Leu Ser Asn  Tyr Pro Glu Pro Pro  Pro Ser Ala 
    2315                 2320                 2325             


Leu Val  Phe Asp Leu His Val  Ser Pro Glu Asp Gly  Thr Leu Val 
    2330                 2335                 2340             


Pro Phe  Thr Gly Gln Tyr Leu  Ser Ser His Ile Lys  Gly Thr Leu 
    2345                 2350                 2355             


Gly Thr  Phe His Pro Ser Ile  Gln Thr Glu Arg Leu  Leu Tyr Val 
    2360                 2365                 2370             


Val Asp  Leu Leu Leu Ser Gly  Gly Gln Pro Val Leu  Leu Ala Gly 
    2375                 2380                 2385             


Glu Ala  Ala Thr Gly Lys Ser  Ala Phe Val Glu Val  Leu Val Glu 
    2390                 2395                 2400             


Pro His  His Pro Tyr Ile Tyr  Ser Pro Ile His Pro  Ala Phe Ser 
    2405                 2410                 2415             


Ser Ser  His Leu Arg Leu Leu  Leu Ser Arg Gly Ile  Gln Gly Gln 
    2420                 2425                 2430             


Thr Gln  Ala Ser Pro Gln Pro  Gly His His Gln Asp  Ser Lys Pro 
    2435                 2440                 2445             


Ser Leu  Leu Phe Leu Leu Glu  Asp Leu His Leu Ala  Thr Ser Asp 
    2450                 2455                 2460             


Pro Glu  Lys Ser Cys Gln Pro  Val Leu Glu Thr Leu  Arg Gln Ala 
    2465                 2470                 2475             


Met Asp  Gly Thr Val Tyr Ala  His Ser Thr Leu Glu  Leu Gln Thr 
    2480                 2485                 2490             


Leu Gln  Pro Thr Val Asn Phe  Leu Ala Thr Val Thr  Val Pro Gly 
    2495                 2500                 2505             


Tyr Cys  Glu Arg Pro Leu Cys  Pro Arg Leu Phe Arg  Leu Phe Thr 
    2510                 2515                 2520             


Val Leu  Ala Leu Glu Ser Met  Thr Gln Ala Thr Leu  Leu Glu Arg 
    2525                 2530                 2535             


His Val  Pro Ile Ile Gln Ala  Trp Leu Glu Arg Phe  Pro Ser Val 
    2540                 2545                 2550             


Glu Arg  Glu Arg Ala Leu Ala  Arg Gly Leu Val Arg  Ala Ser Val 
    2555                 2560                 2565             


Glu Ala  Trp Glu Ala Val Cys  Asn Cys Phe Met Pro  Ser Pro Leu 
    2570                 2575                 2580             


His Pro  His Tyr His Phe Ser  Leu His Ser Val Ser  His Leu Leu 
    2585                 2590                 2595             


Ser Ser  Leu Gln Leu Leu Pro  Asn Arg Thr Gly Ser  Arg Gly Phe 
    2600                 2605                 2610             


Val Asp  Tyr Pro Asn His Gln  Glu His Leu Arg Arg  Val Ser Gly 
    2615                 2620                 2625             


Leu Arg  Gly Thr Cys Leu Thr  Val Met Met Ala Thr  Arg Asn Val 
    2630                 2635                 2640             


Val Arg  Leu Trp Leu His Glu  Ala Gln Arg Thr Phe  Cys Asp Arg 
    2645                 2650                 2655             


Leu Asp  Ser Pro Arg Glu Arg  Ser Tyr Cys Ala Lys  Leu Leu Leu 
    2660                 2665                 2670             


Val Val  Ala Gln Ser Val Phe  Cys Cys Gly Pro Gly  Pro Gln His 
    2675                 2680                 2685             


Leu Gly  Lys Asp His Gln Glu  Ser Glu Glu Glu Glu  Glu Glu Glu 
    2690                 2695                 2700             


Arg Val  Pro Glu Val Glu Ser  Glu Gly Glu Leu Ala  Gln Trp Glu 
    2705                 2710                 2715             


Asp Phe  Ser Asn Ser Asn Ser  Glu Thr Glu Glu Glu  Glu Glu Pro 
    2720                 2725                 2730             


Tyr Gly  Leu Gln Val Ala Arg  Val Ser Asn Ser Arg  Asp Pro Ser 
    2735                 2740                 2745             


Leu Thr  Pro Ser Ile Gly Pro  Val Ser Arg Gly Met  Lys Glu Ser 
    2750                 2755                 2760             


Ile Ser  His Lys Ile Arg Gln  Glu Lys Gly Thr Arg  Ala Ser Asn 
    2765                 2770                 2775             


Tyr Arg  Leu Gln Val Arg Arg  Ser Phe Lys Thr Trp  Trp Gln Lys 
    2780                 2785                 2790             


Lys Pro  Gln Met Asp Leu Ile  Ser Pro Leu Leu Leu  Pro Val Leu 
    2795                 2800                 2805             


Leu Leu  His Pro Gln Glu Lys  Pro Ser Asp Leu Val  Phe Ser Gln 
    2810                 2815                 2820             


Glu Leu  Ile Leu Gly Pro Asn  Ser Glu Thr Pro Asn  Leu Tyr Leu 
    2825                 2830                 2835             


Glu Arg  Gln Trp Glu Lys Leu  Glu Glu Gln Leu Ala  Thr Ser Ala 
    2840                 2845                 2850             


Ala Gln  Leu Lys Leu Ser Pro  His Leu Ala Arg Cys  His Ser Met 
    2855                 2860                 2865             


Ala Gln  His Val Ala Arg Leu  Val Arg Val Leu Ala  Arg Pro Arg 
    2870                 2875                 2880             


Gln His  Gly Leu Leu Leu Ser  Gly Ala Leu Gly Thr  Gly Arg His 
    2885                 2890                 2895             


Thr Ala  Ile Thr Leu Ala Ser  Ser Ile Cys Gln Ala  His Phe Phe 
    2900                 2905                 2910             


His Leu  Pro Ser Gly Ser Glu  Glu Ala Ile Leu Gln  Cys Leu Arg 
    2915                 2920                 2925             


Asp Ala  Ser Trp His Ala Gly  Met Leu Ser Gln Pro  Val Ala Leu 
    2930                 2935                 2940             


Leu Val  Pro Ser Gly Val Asp  Leu Thr Thr Leu His  Arg Leu Leu 
    2945                 2950                 2955             


Ala Leu  Ala Thr Ser Gly Ser  Phe Pro Gly Gln Tyr  Thr Glu Ala 
    2960                 2965                 2970             


Asp Leu  Asp Arg Ile Gly Glu  His Leu Pro Arg Glu  Asn Leu Gly 
    2975                 2980                 2985             


Val Lys  Gln Asn Ile Lys Lys  Glu Met Val Leu Gln  Arg Phe His 
    2990                 2995                 3000             


Gln Gln  Val Cys Ser His Leu  His Leu Phe Phe Leu  Ile Gly Asp 
    3005                 3010                 3015             


Lys Gln  Ala His Lys Gln Leu  Pro Ser Thr Leu Phe  Leu Arg Leu 
    3020                 3025                 3030             


Leu Gln  Leu Ala Thr Ala Ser  Ile Asp Arg Tyr Glu  Pro Trp Asp 
    3035                 3040                 3045             


Gln Ala  Ala Leu Ala Lys Val  Ala Gln His His Leu  Glu Gly Ala 
    3050                 3055                 3060             


Gln Ser  Val Pro Leu Asp Asp  Gly Ser Trp Lys Tyr  Pro Asp Leu 
    3065                 3070                 3075             


Gln Ala  Ser Ile Pro Ser Val  Ala Lys Ala Met Ala  Leu Ile His 
    3080                 3085                 3090             


Leu Ser  Ala Thr His Tyr His  Glu His Leu Cys Pro  Ala Leu Pro 
    3095                 3100                 3105             


Leu Val  Thr Pro Lys Thr Phe  Leu Asp Phe Leu Asp  Thr Phe Leu 
    3110                 3115                 3120             


Met Leu  Gln Gln Gln Thr Ile  Leu Lys Ile Lys Asn  Lys Ala Gln 
    3125                 3130                 3135             


Arg Val  Gln Asn Ala Leu Glu  Asn Leu Arg Met Leu  Ile Lys Glu 
    3140                 3145                 3150             


His Gly  Thr His Ala Asn Leu  Ile Phe Asp Leu Glu  Gln Gln Leu 
    3155                 3160                 3165             


Lys Asp  Ser Gly Lys Ser Leu  Ser Met Phe Gln Gln  Gln Leu Glu 
    3170                 3175                 3180             


Gln Ser  Lys Leu Leu Tyr Lys  Gln Gln Leu Glu Glu  Cys Arg His 
    3185                 3190                 3195             


Gln Glu  Asn Leu Ile Glu Asn  Leu Ala Arg Gln Arg  Asp Ala Leu 
    3200                 3205                 3210             


Gln Ala  Gln Arg Glu Ala Phe  Leu Glu Gln Met Ser  Lys Ala Phe 
    3215                 3220                 3225             


Leu Glu  Pro Leu Ser Gln Leu  Gln Val Ala Asp Phe  Glu Glu Ile 
    3230                 3235                 3240             


Arg Ser  Tyr Arg Ala Pro Pro  Glu Ser Val Val Arg  Val Thr Asp 
    3245                 3250                 3255             


Ala Met  Cys Asp Leu Phe His  His Glu Thr Gly Trp  Ala Ser Ala 
    3260                 3265                 3270             


Lys Gln  Leu Leu Cys Thr Glu  Asp Phe Tyr Gln Glu  Leu Val Phe 
    3275                 3280                 3285             


Phe Pro  Lys Glu Lys Ile Thr  Asp Ser Glu Leu Ile  Lys Leu His 
    3290                 3295                 3300             


Leu Ile  Leu Lys Ala Pro Gly  Met Asp Asp Ala Ala  Leu Arg Ala 
    3305                 3310                 3315             


Val Ser  Arg Pro Ala Ala Ser  Leu Ala Ala Trp Leu  Trp Ala Val 
    3320                 3325                 3330             


Leu His  Tyr Gly Leu Ala His  Cys Arg Gly Leu Pro  Thr Asp Leu 
    3335                 3340                 3345             


Leu Leu  Gln Gln Val Glu Ala  Thr Leu Thr Arg Glu  Gln Ala Arg 
    3350                 3355                 3360             


Leu Gly  Tyr Tyr Gln Phe Gln  Ala Gln Glu Thr Leu  Glu His Asn 
    3365                 3370                 3375             


Leu Ala  Leu Ala Lys Met Val  Glu Asp Ala Gln Ala  Ser His Asn 
    3380                 3385                 3390             


Cys Val  Ala Lys Thr Leu Ser  Gln Ala Gln Cys Gly  Gln Tyr His 
    3395                 3400                 3405             


Lys Trp  Pro Met Lys Ala Ala  Leu Leu Thr Pro Met  Arg Ala Trp 
    3410                 3415                 3420             


Thr Thr  Gln Leu Gln Lys Leu  Lys Gly Arg Cys Met  Thr Val Phe 
    3425                 3430                 3435             


Gly Asp  Thr Leu Leu Cys Ser  Ala Ala Ile Ile Tyr  Leu Gly Pro 
    3440                 3445                 3450             


Phe Pro  Pro Leu Arg Arg Gln  Glu Leu Leu Asp Glu  Trp Leu Ala 
    3455                 3460                 3465             


Leu Cys  Arg Gly Phe Gln Glu  Ala Leu Gly Pro Asp  Asp Val Ala 
    3470                 3475                 3480             


Gln Ala  Leu Lys Arg Lys Gln  Lys Ser Val Ser Ile  Pro Pro Lys 
    3485                 3490                 3495             


Asn Pro  Leu Leu Ala Thr His  Ser Pro Phe Ser Ile  Leu Ser Leu 
    3500                 3505                 3510             


Leu Ser  Ser Glu Ser Glu Gln  Tyr Gln Trp Asp Gly  Asn Leu Lys 
    3515                 3520                 3525             


Pro Gln  Ala Lys Ser Ala His  Leu Ala Gly Leu Leu  Leu Arg Ser 
    3530                 3535                 3540             


Pro Thr  His Tyr Ser Ser Cys  Arg Trp Pro Leu Leu  Leu Asp Pro 
    3545                 3550                 3555             


Ser Asn  Glu Ala Leu Ile Trp  Leu Asp Pro Leu Pro  Leu Glu Glu 
    3560                 3565                 3570             


Asn Arg  Ser Phe Ala Pro Ala  Leu Thr Glu Gly Arg  Gly Lys Gly 
    3575                 3580                 3585             


Leu Met  Arg Asn Gln Lys Arg  Glu Ser Lys Thr Asp  Met Lys Glu 
    3590                 3595                 3600             


Glu Asp  Asp Glu Ser Glu Glu  Ser Asn Glu Ala Glu  Asp Gln Thr 
    3605                 3610                 3615             


Lys Glu  Gln Lys Ala Glu Glu  Arg Lys Asn Glu Gln  Glu Lys Glu 
    3620                 3625                 3630             


Gln Glu  Glu Asn Glu Glu Lys  Glu Glu Glu Lys Thr  Glu Ser Gln 
    3635                 3640                 3645             


Gly Ser  Lys Pro Ala Tyr Glu  Thr Gln Leu Pro Ser  Leu Pro Tyr 
    3650                 3655                 3660             


Leu Ser  Val Leu Ser Gly Ala  Asp Pro Glu Leu Gly  Ser Gln Leu 
    3665                 3670                 3675             


Gln Glu  Ala Ala Ala Cys Gly  Leu Pro Val Leu Leu  Thr Asn Val 
    3680                 3685                 3690             


Glu Leu  Gly Leu Gly Cys Glu  Glu Leu Gln Trp Leu  Leu Gln Arg 
    3695                 3700                 3705             


Glu Gln  Leu Ser Pro Pro Gln  Val Gln Pro Gly Phe  Cys Leu Tyr 
    3710                 3715                 3720             


Leu Ser  Thr Thr Leu Ser Leu  Cys Ala Met Glu Lys  Val Leu Gly 
    3725                 3730                 3735             


Cys Glu  Leu Leu Lys Gly Leu  Asn Val Leu Asp Leu  Gly Leu Asn 
    3740                 3745                 3750             


Met Glu  Ile Leu Glu Glu Gln  Met Leu His Glu Ile  Leu Cys Arg 
    3755                 3760                 3765             


Glu Tyr  Pro Glu Leu Glu Thr  Arg Trp Gln Asp Leu  Lys Ile Arg 
    3770                 3775                 3780             


Ala Leu  Asp Thr Cys Lys Ala  Val Glu Ala Ala Glu  Glu Arg Leu 
    3785                 3790                 3795             


Leu Thr  Met Leu Leu Phe Gln  Asn Pro Lys Arg Gln  Lys Pro Ala 
    3800                 3805                 3810             


Lys Phe  Leu Arg Asn Ile Val  Arg Ala Gln Gly Lys  Leu Cys Gln 
    3815                 3820                 3825             


Leu Arg  Ala His Cys Glu Glu  Leu Glu Gly Gln Lys  Leu Gln Glu 
    3830                 3835                 3840             


Met Val  Leu Trp Ala Pro Tyr  Arg Pro Val Val Trp  His Gly Met 
    3845                 3850                 3855             


Ala Met  Val Lys Ala Leu Ser  Gln Leu Gln Asn Leu  Leu Pro Leu 
    3860                 3865                 3870             


Phe Cys  Met Ser Pro Glu Asn  Trp Leu Ala Val Thr  Lys Gln Ala 
    3875                 3880                 3885             


Leu Asp  Ser Met Lys Pro Arg  Glu Ile Asn His Gly  Glu Asp Leu 
    3890                 3895                 3900             


Ala Ser  His Leu Leu Gln Leu  Arg Ala His Leu Thr  Arg Gln Leu 
    3905                 3910                 3915             


Leu Gly  Ser Thr Val Thr Ala  Leu Gly Leu Thr Gln  Val Pro Leu 
    3920                 3925                 3930             


Val Gly  Ala Leu Gly Ala Leu  Ala Leu Leu Gln Ala  Thr Gly Lys 
    3935                 3940                 3945             


Ala Ser  Glu Leu Glu Arg Leu  Ala Leu Trp Pro Gly  Leu Ala Ala 
    3950                 3955                 3960             


Ser Pro  Ser Thr Val His Ser  Lys Pro Val Ser Asp  Val Ala Arg 
    3965                 3970                 3975             


Pro Ala  Trp Leu Gly Pro Lys  Ala Trp His Glu Cys  Glu Met Leu 
    3980                 3985                 3990             


Glu Leu  Leu Pro Pro Phe Val  Gly Leu Cys Ala Ser  Leu Ala Gly 
    3995                 4000                 4005             


His Ser  Ser Ala Trp Gln Ala  Tyr Leu Ser Leu Ser  Ser Thr Val 
    4010                 4015                 4020             


Leu Gly  Pro Ala Pro Gly Pro  Gly Pro Glu Pro Leu  Ser Leu Leu 
    4025                 4030                 4035             


Gln Lys  Leu Ile Leu Trp Arg  Val Leu Arg Pro Glu  Cys Leu Ala 
    4040                 4045                 4050             


Gly Ala  Leu Ala Asp Phe Thr  Thr Ser Leu Leu Gly  Arg Pro Leu 
    4055                 4060                 4065             


Asp Glu  Asn Thr Tyr Ala Pro  Thr Met Pro Phe Lys  His Ser Gln 
    4070                 4075                 4080             


Ala Thr  Gln Pro Met Leu Ile  Leu Leu Pro Pro Pro  Gly His Pro 
    4085                 4090                 4095             


Ser Ala  Thr Leu His Pro Leu  Thr Val Ile Gln Lys  Leu Ala Ala 
    4100                 4105                 4110             


Lys Tyr  Gln Gln Gly Gln Lys  Gln Leu Gln Val Ile  Ala Leu Gly 
    4115                 4120                 4125             


Ser Glu  Ala Trp Asp Pro Val  Ser Val Val Val Ser  Thr Leu Ser 
    4130                 4135                 4140             


Gln Ala  Met Tyr Glu Gly His  Trp Leu Val Leu Asp  Asn Cys His 
    4145                 4150                 4155             


Leu Met  Pro His Trp Pro Lys  Glu Leu Leu Gln Leu  Leu Leu Glu 
    4160                 4165                 4170             


Leu Leu  Gly Arg Ala Lys Val  Val Ala Asp Leu Glu  Ser Glu Gln 
    4175                 4180                 4185             


Leu Leu  Asp Gln Pro Glu Ser  Arg Asn Val Ser Thr  Val His Arg 
    4190                 4195                 4200             


Asp Phe  Arg Leu Trp Leu Ile  Val Pro Ala Glu Ser  Ser Ala Ser 
    4205                 4210                 4215             


Leu Pro  Ala Val Leu Thr Gln  His Ser Met Pro Val  Phe Trp Asn 
    4220                 4225                 4230             


Gln Ser  Leu Glu Leu Gly His  Val Leu Ile Asp Ser  Val Glu Leu 
    4235                 4240                 4245             


Ala Gln  Gln Val Leu Tyr Met  Gln Pro Pro Thr Gln  Ala Leu Pro 
    4250                 4255                 4260             


Leu Leu  Leu Leu His Gly Leu  Leu Leu His Arg Gln  Leu Tyr Gly 
    4265                 4270                 4275             


Thr Arg  Leu Gln Ala His Arg  Gly Arg Trp Ser Gln  Val Thr Leu 
    4280                 4285                 4290             


Thr Gln  Val Leu Gln Thr Gln  Asp Gln Leu Trp Ala  Ser Leu Ser 
    4295                 4300                 4305             


Asn Pro  Arg Ala Ala Met Gln  Glu Leu Ala Ala Ser  Val Phe Tyr 
    4310                 4315                 4320             


Gly Gly  Pro Leu Gly Asp Thr  Glu Asp Arg Glu Ala  Leu Ile Ser 
    4325                 4330                 4335             


Leu Thr  Gln Ala Cys Leu Ser  Pro Ser Ser Gly Ser  Trp Val Gln 
    4340                 4345                 4350             


Pro His  Thr Pro Gln Ser Leu  Leu Ala Thr Leu Met  Pro Leu Pro 
    4355                 4360                 4365             


Glu Leu  Arg Glu Leu Asp Ala  Met Ala Glu Cys Lys  Ala Gln Met 
    4370                 4375                 4380             


His Leu  Leu Pro Ser Pro Pro  Glu Pro Arg Leu Cys  Gly Leu Ser 
    4385                 4390                 4395             


Glu Gly  Pro Gln Ala Trp Leu  Leu Arg Arg Gln Ser  Arg Ala Leu 
    4400                 4405                 4410             


Leu Ser  Ala Leu Gln Arg Ser  Ser Pro Val Trp Val  Pro Glu Ser 
    4415                 4420                 4425             


Arg Arg  Gly Ala Gln Leu Ala  Glu Arg Arg Leu Arg  Gln Arg Leu 
    4430                 4435                 4440             


Val Gln  Val Asn Arg Arg Leu  Glu Ser Leu Gln Asp  Leu Leu Thr 
    4445                 4450                 4455             


His Val  Ile Arg Gln Asp Glu  Ser Asp Ala Pro Trp  Ser Val Leu 
    4460                 4465                 4470             


Gly Pro  Asn Ala Arg Arg Pro  Leu Glu Gly Val Leu  Glu Thr Glu 
    4475                 4480                 4485             


Ala Leu  Glu Leu Ser Gln Leu  Val Gly Thr Leu Gln  Arg Asp Leu 
    4490                 4495                 4500             


Asp Cys  Leu Leu Gln Gln Leu  Lys Gly Ala Pro Pro  Cys Pro Ser 
    4505                 4510                 4515             


Arg Arg  Cys Ala Ala Val Ala  His Ala Leu Trp Thr  Gly Arg Leu 
    4520                 4525                 4530             


Pro Leu  Pro Trp Arg Pro His  Ala Pro Ala Gly Pro  Gln Pro Pro 
    4535                 4540                 4545             


Trp His  Trp Leu Arg Gln Leu  Ser Arg Arg Gly Gln  Leu Leu Val 
    4550                 4555                 4560             


Arg Tyr  Leu Gly Val Gly Ala  Asp Ala Ser Ser Asp  Val Pro Glu 
    4565                 4570                 4575             


Arg Val  Phe His Leu Ser Ala  Phe Arg His Pro Arg  Arg Leu Leu 
    4580                 4585                 4590             


Leu Ala  Leu Arg Gly Glu Ala  Ala Leu Asp Gln Asn  Val Pro Ser 
    4595                 4600                 4605             


Ser Asn  Phe Pro Gly Ser Arg  Gly Ser Val Ser Ser  Gln Leu Gln 
    4610                 4615                 4620             


Tyr Lys  Arg Leu Glu Met Asn  Ser Asn Pro Leu His  Phe Arg Val 
    4625                 4630                 4635             


Glu Asn  Gly Pro Asn Pro Thr  Val Pro Glu Arg Gly  Leu Leu Leu 
    4640                 4645                 4650             


Ile Gly  Leu Gln Val Leu His  Ala Glu Trp Asp Pro  Ile Ala Gly 
    4655                 4660                 4665             


Ala Leu  Gln Asp Ser Pro Ser  Ser Gln Pro Ser Pro  Leu Pro Pro 
    4670                 4675                 4680             


Val Ser  Ile Ser Thr Gln Ala  Pro Gly Thr Ser Asp  Leu Pro Ala 
    4685                 4690                 4695             


Pro Ala  Asp Leu Thr Val Tyr  Ser Cys Pro Val Tyr  Met Gly Gly 
    4700                 4705                 4710             


Pro Leu  Gly Thr Ala Lys Leu  Gln Ser Arg Asn Ile  Val Met His 
    4715                 4720                 4725             


Leu Pro  Leu Pro Thr Lys Leu  Thr Pro Asn Thr Cys  Val Gln Arg 
    4730                 4735                 4740             


Arg Val  His Val Cys Ser Pro  Pro Leu Ser 
    4745                 4750             


<210>  711
<211>  2840
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (268)..(1344)

<400>  711
ccgcactgac atggccgtcg cccggttccg cgcgtccgcc gcgcgccggc cgttaatagg       60

cttgctccct gagcgccccg caccgacatg gcggccgtct tcgctgtggt gactttaact      120

ctcggttttc ggttatagcc ggccggcgct cacttgtctt caggaagctc ggagcctttg      180

gtggagccgg ggagaggaag ggtgggtgca agagtgaaag gcgagagggg actgcaagca      240

tccgggtcgg ctcctggccg gagcaag atg gct gag ggc gag cgg cag ccg ccg      294
                              Met Ala Glu Gly Glu Arg Gln Pro Pro         
                              1               5                           

cca gat tct tca gag gag gcc cct cca gcc act cag aac ttc atc att        342
Pro Asp Ser Ser Glu Glu Ala Pro Pro Ala Thr Gln Asn Phe Ile Ile           
10                  15                  20                  25            

cca aaa aag gag atc cac aca gtt cca gac atg ggc aaa tgg aag cgt        390
Pro Lys Lys Glu Ile His Thr Val Pro Asp Met Gly Lys Trp Lys Arg           
                30                  35                  40                

tct cag gca tac gct gac tac atc gga ttc atc ctt acc ctc aac gaa        438
Ser Gln Ala Tyr Ala Asp Tyr Ile Gly Phe Ile Leu Thr Leu Asn Glu           
            45                  50                  55                    

ggt gtg aag ggg aag aag ctg acc ttc gag tac aga gtc tcc gag atg        486
Gly Val Lys Gly Lys Lys Leu Thr Phe Glu Tyr Arg Val Ser Glu Met           
        60                  65                  70                        

tgg aat gag gtt cat gag gaa aag gag cag gct gca aag cag agt gtg        534
Trp Asn Glu Val His Glu Glu Lys Glu Gln Ala Ala Lys Gln Ser Val           
    75                  80                  85                            

tcc tgc gat gaa tgc ata cca tta ccc cgc gcc ggg cac tgt gca cct        582
Ser Cys Asp Glu Cys Ile Pro Leu Pro Arg Ala Gly His Cys Ala Pro           
90                  95                  100                 105           

tcg gag gcc att gag aaa cta gtc gct ctt ctc aac acg ctg gac agg        630
Ser Glu Ala Ile Glu Lys Leu Val Ala Leu Leu Asn Thr Leu Asp Arg           
                110                 115                 120               

tgg att gat gag act cct cca gtg gac cag ccc tct cgg ttt ggg aat        678
Trp Ile Asp Glu Thr Pro Pro Val Asp Gln Pro Ser Arg Phe Gly Asn           
            125                 130                 135                   

aag gca tac agg acc tgg tat gcc aaa ctt gat gag gaa gca gaa aac        726
Lys Ala Tyr Arg Thr Trp Tyr Ala Lys Leu Asp Glu Glu Ala Glu Asn           
        140                 145                 150                       

ttg gtg gcc aca gtg gtc cct acc cat ctg gca gct gct gtg cct gag        774
Leu Val Ala Thr Val Val Pro Thr His Leu Ala Ala Ala Val Pro Glu           
    155                 160                 165                           

gtg gct gtt tac cta aag gag tca gtg ggg aac tcc acg cgc att gac        822
Val Ala Val Tyr Leu Lys Glu Ser Val Gly Asn Ser Thr Arg Ile Asp           
170                 175                 180                 185           

tac ggc aca ggg cat gag gca gcc ttc gct gct ttc ctc tgc tgt ctc        870
Tyr Gly Thr Gly His Glu Ala Ala Phe Ala Ala Phe Leu Cys Cys Leu           
                190                 195                 200               

tgc aag att ggg gtg ctc cgg gtg gat gac caa ata gct att gtc ttc        918
Cys Lys Ile Gly Val Leu Arg Val Asp Asp Gln Ile Ala Ile Val Phe           
            205                 210                 215                   

aag gtg ttc aat cgg tac ctt gag gtt atg cgg aaa ctc cag aaa aca        966
Lys Val Phe Asn Arg Tyr Leu Glu Val Met Arg Lys Leu Gln Lys Thr           
        220                 225                 230                       

tac agg atg gag cca gcc ggc agc cag gga gtg tgg ggt ctg gat gac       1014
Tyr Arg Met Glu Pro Ala Gly Ser Gln Gly Val Trp Gly Leu Asp Asp           
    235                 240                 245                           

ttc cag ttt ctg ccc ttc atc tgg ggc agt tcg cag ctg ata gac cac       1062
Phe Gln Phe Leu Pro Phe Ile Trp Gly Ser Ser Gln Leu Ile Asp His           
250                 255                 260                 265           

cca tac ctg gag ccc aga cac ttt gtg gat gag aag gcc gtg aat gag       1110
Pro Tyr Leu Glu Pro Arg His Phe Val Asp Glu Lys Ala Val Asn Glu           
                270                 275                 280               

aac cac aag gac tac atg ttc ctg gag tgt atc ctg ttt att acc gag       1158
Asn His Lys Asp Tyr Met Phe Leu Glu Cys Ile Leu Phe Ile Thr Glu           
            285                 290                 295                   

atg aag act ggc cca ttt gca gag cac tcc aac cag ctg tgg aac atc       1206
Met Lys Thr Gly Pro Phe Ala Glu His Ser Asn Gln Leu Trp Asn Ile           
        300                 305                 310                       

agc gcc gtc cct tcc tgg tcc aaa gtg aac cag ggt ctc atc cgc atg       1254
Ser Ala Val Pro Ser Trp Ser Lys Val Asn Gln Gly Leu Ile Arg Met           
    315                 320                 325                           

tat aag gcc gag tgc ctg gag aag ttc cct gtg atc cag cac ttc aag       1302
Tyr Lys Ala Glu Cys Leu Glu Lys Phe Pro Val Ile Gln His Phe Lys           
330                 335                 340                 345           

ttc ggg agc ctg ctg ccc atc cat cct gtc acg tcg ggc tag               1344
Phe Gly Ser Leu Leu Pro Ile His Pro Val Thr Ser Gly                       
                350                 355                                   

gaggggccaa gccgaagagc cacccaggcc acagttcctg tgcctgcctt ccccacccca     1404

gcagtggccc ctccccatcc cctccctctg ttcgtcccgt ttgatgagag gctgtttact     1464

ggggtggggt ggcgagatgg gcttgagggg gctcagagca taaggcttca gggcccaagt     1524

tgggagaagt gaccaaagtg tagccagttt tctgagttcc cgtgtgctag actggccaga     1584

agagagggtc tggggcctgg tcactcggcc actctctcct gtttctggcc tcttctccct     1644

tcactcccgt ccagtctggt tttgagagca ggggctgttc tgcagcaccg cagggaaggg     1704

aggagagata cctgctgctt ccattgcttt tcccttcctg gagtcgatgc ctttctaagg     1764

gttggagctg ctccttgcag gggcgggtca gtttcccagg ccatgccggg gtggccatct     1824

atggtagggc tggaagctga ggctggccgc cagctgtggg ctggggtggg gtgggtgggg     1884

tcgggtggtg gagaggcctt agctgtcctg gctggtgccc ctcccaggct ccttttcacc     1944

ctgccccctg ggcctgaggc cccctgtgtc caagcctccc cctggctctt cagttctcta     2004

gcccttggct ctgctgggtt tcctgactgt agccacatct ctcccgctcc ctaagggtaa     2064

cctagccaat ggaagctgcc ctttgggtag gtgctgggct cctgggaggg cccagatgat     2124

ggggtgaggc atgtctttcc agaactttcc ctggcaggga ggggatggca gaaactcagg     2184

gaggggcttg gggcccattg tatctggaga gcctggattc ctcttggcag tcttaggccc     2244

ggccacttct gctacctttg cgctgctgtg agcctcaccc tgggcccctg ggccctgctt     2304

ctctgctccc ctgggtgatg ggtgggccca gaaggtggca gtcccacacc ttgtcctccc     2364

acctccctga actgtccatt gcttttatag ggtgaggtaa gagacagcct cccaagccca     2424

ggctttggca ctcagaatgg gcccagtggg ggctgggcag gcccattgag ggccaccgcc     2484

gaggtttctc ctagggctgt tcctgggcct ggctcttaca ggctcgtccc ccaggcctgc     2544

ccttctccac tgccccctcc tgtgtctggg tccacacacc cttcaggaag ggggagcact     2604

gagaagcaca gcacaggggc tcagcctggg atccggtgat ggtctgggca gaggctgggt     2664

caggagtccc aaaggtcagt gacagtttct cagaagaggc ccagcgtcca cctctctccc     2724

agggccagac agcccttcct ggctccccca tccccctatg ggctcccagc cccttgcacc     2784

ctcattgctg ttcagattaa agcctctgtt ttgcacctgt aaaaaaaaaa aaaaaa         2840


<210>  712
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  712

Met Ala Glu Gly Glu Arg Gln Pro Pro Pro Asp Ser Ser Glu Glu Ala 
1               5                   10                  15      


Pro Pro Ala Thr Gln Asn Phe Ile Ile Pro Lys Lys Glu Ile His Thr 
            20                  25                  30          


Val Pro Asp Met Gly Lys Trp Lys Arg Ser Gln Ala Tyr Ala Asp Tyr 
        35                  40                  45              


Ile Gly Phe Ile Leu Thr Leu Asn Glu Gly Val Lys Gly Lys Lys Leu 
    50                  55                  60                  


Thr Phe Glu Tyr Arg Val Ser Glu Met Trp Asn Glu Val His Glu Glu 
65                  70                  75                  80  


Lys Glu Gln Ala Ala Lys Gln Ser Val Ser Cys Asp Glu Cys Ile Pro 
                85                  90                  95      


Leu Pro Arg Ala Gly His Cys Ala Pro Ser Glu Ala Ile Glu Lys Leu 
            100                 105                 110         


Val Ala Leu Leu Asn Thr Leu Asp Arg Trp Ile Asp Glu Thr Pro Pro 
        115                 120                 125             


Val Asp Gln Pro Ser Arg Phe Gly Asn Lys Ala Tyr Arg Thr Trp Tyr 
    130                 135                 140                 


Ala Lys Leu Asp Glu Glu Ala Glu Asn Leu Val Ala Thr Val Val Pro 
145                 150                 155                 160 


Thr His Leu Ala Ala Ala Val Pro Glu Val Ala Val Tyr Leu Lys Glu 
                165                 170                 175     


Ser Val Gly Asn Ser Thr Arg Ile Asp Tyr Gly Thr Gly His Glu Ala 
            180                 185                 190         


Ala Phe Ala Ala Phe Leu Cys Cys Leu Cys Lys Ile Gly Val Leu Arg 
        195                 200                 205             


Val Asp Asp Gln Ile Ala Ile Val Phe Lys Val Phe Asn Arg Tyr Leu 
    210                 215                 220                 


Glu Val Met Arg Lys Leu Gln Lys Thr Tyr Arg Met Glu Pro Ala Gly 
225                 230                 235                 240 


Ser Gln Gly Val Trp Gly Leu Asp Asp Phe Gln Phe Leu Pro Phe Ile 
                245                 250                 255     


Trp Gly Ser Ser Gln Leu Ile Asp His Pro Tyr Leu Glu Pro Arg His 
            260                 265                 270         


Phe Val Asp Glu Lys Ala Val Asn Glu Asn His Lys Asp Tyr Met Phe 
        275                 280                 285             


Leu Glu Cys Ile Leu Phe Ile Thr Glu Met Lys Thr Gly Pro Phe Ala 
    290                 295                 300                 


Glu His Ser Asn Gln Leu Trp Asn Ile Ser Ala Val Pro Ser Trp Ser 
305                 310                 315                 320 


Lys Val Asn Gln Gly Leu Ile Arg Met Tyr Lys Ala Glu Cys Leu Glu 
                325                 330                 335     


Lys Phe Pro Val Ile Gln His Phe Lys Phe Gly Ser Leu Leu Pro Ile 
            340                 345                 350         


His Pro Val Thr Ser Gly 
        355             


<210>  713
<211>  1349
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (77)..(1270)

<400>  713
cctgtcctgt aggacctccc tctcctgagg ccaccactgg gcccccttct gagtgtcccc       60

tgagcactct ctcagc atg aac tgc ata tcc gac ttc ttc acc tat gag acc      112
                  Met Asn Cys Ile Ser Asp Phe Phe Thr Tyr Glu Thr         
                  1               5                   10                  

acc aag tcg gtg gtt gtg aag agc tgg acc atc ggg atc atc aac cga        160
Thr Lys Ser Val Val Val Lys Ser Trp Thr Ile Gly Ile Ile Asn Arg           
        15                  20                  25                        

gta gtt cag ctt ctg atc atc tcc tac ttt gta ggg tgg gtt ttc ttg        208
Val Val Gln Leu Leu Ile Ile Ser Tyr Phe Val Gly Trp Val Phe Leu           
    30                  35                  40                            

cac gag aag gct tac cag gta cgg gac aca gcc att gag tcc tcg gtg        256
His Glu Lys Ala Tyr Gln Val Arg Asp Thr Ala Ile Glu Ser Ser Val           
45                  50                  55                  60            

gta acc aag gtg aag ggc tcc gga ctc tac gcc aac aga gtc atg gat        304
Val Thr Lys Val Lys Gly Ser Gly Leu Tyr Ala Asn Arg Val Met Asp           
                65                  70                  75                

gtg tct gat tac gtg acg cca cct cag ggc acc tcg gtc ttt gtc atc        352
Val Ser Asp Tyr Val Thr Pro Pro Gln Gly Thr Ser Val Phe Val Ile           
            80                  85                  90                    

atc acc aag atg att gtt act gaa aat cag atg caa gga ttc tgc cca        400
Ile Thr Lys Met Ile Val Thr Glu Asn Gln Met Gln Gly Phe Cys Pro           
        95                  100                 105                       

gag agt gag gag aaa tac cgc tgt gta tca gac agc cag tgc ggg cct        448
Glu Ser Glu Glu Lys Tyr Arg Cys Val Ser Asp Ser Gln Cys Gly Pro           
    110                 115                 120                           

gag cgc ttg cca ggt ggg ggg atc ctc act ggc cgc tgc gtg aac tac        496
Glu Arg Leu Pro Gly Gly Gly Ile Leu Thr Gly Arg Cys Val Asn Tyr           
125                 130                 135                 140           

agc tct gtg ctc cgg acc tgt gag atc cag ggc tgg tgc ccc acg gag        544
Ser Ser Val Leu Arg Thr Cys Glu Ile Gln Gly Trp Cys Pro Thr Glu           
                145                 150                 155               

gtg gac aca gtg gaa acg ccc atc atg atg gaa gct gag aac ttc act        592
Val Asp Thr Val Glu Thr Pro Ile Met Met Glu Ala Glu Asn Phe Thr           
            160                 165                 170                   

att ttc atc aag aac agc atc cgt ttc ccc ctc ttc aac ttt gag aag        640
Ile Phe Ile Lys Asn Ser Ile Arg Phe Pro Leu Phe Asn Phe Glu Lys           
        175                 180                 185                       

gga aac ctc ctt ccc aac ctg aca gcc agg gac atg aag acc tgc cgc        688
Gly Asn Leu Leu Pro Asn Leu Thr Ala Arg Asp Met Lys Thr Cys Arg           
    190                 195                 200                           

ttc cac ccg gac aag gac cct ttc tgc ccc atc ttg cgg gta ggg gac        736
Phe His Pro Asp Lys Asp Pro Phe Cys Pro Ile Leu Arg Val Gly Asp           
205                 210                 215                 220           

gtg gtc aag ttt gcg ggg cag gat ttt gcc aaa ctg gcg cgc acg ggg        784
Val Val Lys Phe Ala Gly Gln Asp Phe Ala Lys Leu Ala Arg Thr Gly           
                225                 230                 235               

gga gtt ctg ggc att aag atc ggc tgg gtg tgc gac ttg gac aag gcc        832
Gly Val Leu Gly Ile Lys Ile Gly Trp Val Cys Asp Leu Asp Lys Ala           
            240                 245                 250                   

tgg gac cag tgc atc ccc aaa tac tcc ttc acc cgg ctc gac agc gtt        880
Trp Asp Gln Cys Ile Pro Lys Tyr Ser Phe Thr Arg Leu Asp Ser Val           
        255                 260                 265                       

tct gag aaa agc agc gtg tcc cca ggc tac aac ttc agg ttt gcc aag        928
Ser Glu Lys Ser Ser Val Ser Pro Gly Tyr Asn Phe Arg Phe Ala Lys           
    270                 275                 280                           

tac tac aaa atg gaa aat ggc agt gag tac cgc acc ctc ctg aag gct        976
Tyr Tyr Lys Met Glu Asn Gly Ser Glu Tyr Arg Thr Leu Leu Lys Ala           
285                 290                 295                 300           

ttt ggc atc cgc ttc gac gtg ctg gta tac ggg aat gct ggc aag ttc       1024
Phe Gly Ile Arg Phe Asp Val Leu Val Tyr Gly Asn Ala Gly Lys Phe           
                305                 310                 315               

aac atc atc ccc acc atc atc agc tct gtg gcg gcc ttt act tct gtg       1072
Asn Ile Ile Pro Thr Ile Ile Ser Ser Val Ala Ala Phe Thr Ser Val           
            320                 325                 330                   

gga gtg gga act gtt ctc tgt gac atc atc ctg ctc aac ttc ctc aag       1120
Gly Val Gly Thr Val Leu Cys Asp Ile Ile Leu Leu Asn Phe Leu Lys           
        335                 340                 345                       

ggg gcc gac cag tac aaa gcc aag aag ttt gag gag gtg aat gag act       1168
Gly Ala Asp Gln Tyr Lys Ala Lys Lys Phe Glu Glu Val Asn Glu Thr           
    350                 355                 360                           

acg ctg aaa atc gcg gct ttg acc aac cca gtg tac ccc agc gac cag       1216
Thr Leu Lys Ile Ala Ala Leu Thr Asn Pro Val Tyr Pro Ser Asp Gln           
365                 370                 375                 380           

acc aca gcg gag aag cag tcc acc gat tcg ggg gcc ttc tcc ata ggc       1264
Thr Thr Ala Glu Lys Gln Ser Thr Asp Ser Gly Ala Phe Ser Ile Gly           
                385                 390                 395               

cac tag ggcctctttc cagggcccca cactcacaaa ggctccaggc ctccccacag        1320
His                                                                       
                                                                          

aggaccctgc ctgagcaagg ggcatggga                                       1349


<210>  714
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  714

Met Asn Cys Ile Ser Asp Phe Phe Thr Tyr Glu Thr Thr Lys Ser Val 
1               5                   10                  15      


Val Val Lys Ser Trp Thr Ile Gly Ile Ile Asn Arg Val Val Gln Leu 
            20                  25                  30          


Leu Ile Ile Ser Tyr Phe Val Gly Trp Val Phe Leu His Glu Lys Ala 
        35                  40                  45              


Tyr Gln Val Arg Asp Thr Ala Ile Glu Ser Ser Val Val Thr Lys Val 
    50                  55                  60                  


Lys Gly Ser Gly Leu Tyr Ala Asn Arg Val Met Asp Val Ser Asp Tyr 
65                  70                  75                  80  


Val Thr Pro Pro Gln Gly Thr Ser Val Phe Val Ile Ile Thr Lys Met 
                85                  90                  95      


Ile Val Thr Glu Asn Gln Met Gln Gly Phe Cys Pro Glu Ser Glu Glu 
            100                 105                 110         


Lys Tyr Arg Cys Val Ser Asp Ser Gln Cys Gly Pro Glu Arg Leu Pro 
        115                 120                 125             


Gly Gly Gly Ile Leu Thr Gly Arg Cys Val Asn Tyr Ser Ser Val Leu 
    130                 135                 140                 


Arg Thr Cys Glu Ile Gln Gly Trp Cys Pro Thr Glu Val Asp Thr Val 
145                 150                 155                 160 


Glu Thr Pro Ile Met Met Glu Ala Glu Asn Phe Thr Ile Phe Ile Lys 
                165                 170                 175     


Asn Ser Ile Arg Phe Pro Leu Phe Asn Phe Glu Lys Gly Asn Leu Leu 
            180                 185                 190         


Pro Asn Leu Thr Ala Arg Asp Met Lys Thr Cys Arg Phe His Pro Asp 
        195                 200                 205             


Lys Asp Pro Phe Cys Pro Ile Leu Arg Val Gly Asp Val Val Lys Phe 
    210                 215                 220                 


Ala Gly Gln Asp Phe Ala Lys Leu Ala Arg Thr Gly Gly Val Leu Gly 
225                 230                 235                 240 


Ile Lys Ile Gly Trp Val Cys Asp Leu Asp Lys Ala Trp Asp Gln Cys 
                245                 250                 255     


Ile Pro Lys Tyr Ser Phe Thr Arg Leu Asp Ser Val Ser Glu Lys Ser 
            260                 265                 270         


Ser Val Ser Pro Gly Tyr Asn Phe Arg Phe Ala Lys Tyr Tyr Lys Met 
        275                 280                 285             


Glu Asn Gly Ser Glu Tyr Arg Thr Leu Leu Lys Ala Phe Gly Ile Arg 
    290                 295                 300                 


Phe Asp Val Leu Val Tyr Gly Asn Ala Gly Lys Phe Asn Ile Ile Pro 
305                 310                 315                 320 


Thr Ile Ile Ser Ser Val Ala Ala Phe Thr Ser Val Gly Val Gly Thr 
                325                 330                 335     


Val Leu Cys Asp Ile Ile Leu Leu Asn Phe Leu Lys Gly Ala Asp Gln 
            340                 345                 350         


Tyr Lys Ala Lys Lys Phe Glu Glu Val Asn Glu Thr Thr Leu Lys Ile 
        355                 360                 365             


Ala Ala Leu Thr Asn Pro Val Tyr Pro Ser Asp Gln Thr Thr Ala Glu 
    370                 375                 380                 


Lys Gln Ser Thr Asp Ser Gly Ala Phe Ser Ile Gly His 
385                 390                 395         


<210>  715
<211>  2618
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (385)..(1623)

<400>  715
gtgaacgggt tgtgggacct gtcgctgtgt gggggctgtc gagcactccc cagaacgtaa       60

caaatcctca ggggaactga tgggcggtcg cgcgggcact gggtcctcca caccctggag      120

agccgttttc cgttgccact cggctctggc cggggtcaca ttctgcagca tgtctgttca      180

ttcccctggg cggggccctg caccgactcc agcccagccc ctgctccctc tgcggggaac      240

gtggccccag gcagtgctgg gccattggct gtcagtgctg gtcctggcgg ctgcattccc      300

agtccccttg gtctctgtga cagtgggcgg ggccggccct cccaggatct gacggcgcag      360

gtcctcccct tctgtgtcct gcag atg gac acc cgc tcc ggg agc cag tgt         411
                           Met Asp Thr Arg Ser Gly Ser Gln Cys            
                           1               5                              

tcc gtc acc cca gaa gcc ata ctc aat aat gaa aag ctg gtc ttg ccg        459
Ser Val Thr Pro Glu Ala Ile Leu Asn Asn Glu Lys Leu Val Leu Pro           
10                  15                  20                  25            

ccc cgc atc tcc aga gtg aac ggc tgg tcg tta ccc ctg cac tac ttc        507
Pro Arg Ile Ser Arg Val Asn Gly Trp Ser Leu Pro Leu His Tyr Phe           
                30                  35                  40                

cag gtg gtg acc tgg gct gtc ttc gtg ggc ctt tcc tcg gcc acc ttc        555
Gln Val Val Thr Trp Ala Val Phe Val Gly Leu Ser Ser Ala Thr Phe           
            45                  50                  55                    

ggg atc ttc att ccc ttc ctg cct cac gcg tgg aaa tac att gcc tac        603
Gly Ile Phe Ile Pro Phe Leu Pro His Ala Trp Lys Tyr Ile Ala Tyr           
        60                  65                  70                        

gtg gtg acc ggg ggg atc ttc tcg ttc cac ctc gtc gtc cac ctg atc        651
Val Val Thr Gly Gly Ile Phe Ser Phe His Leu Val Val His Leu Ile           
    75                  80                  85                            

gcg tcc tgc atc gac ccg gcc gac tcc aat gtc aga ctc atg aag aac        699
Ala Ser Cys Ile Asp Pro Ala Asp Ser Asn Val Arg Leu Met Lys Asn           
90                  95                  100                 105           

tat tct cag ccc atg ccc ctc ttc gac aga tca aaa cat gca cac gtg        747
Tyr Ser Gln Pro Met Pro Leu Phe Asp Arg Ser Lys His Ala His Val           
                110                 115                 120               

atc cag aat cag ttc tgc cac ctg tgc aag gtc acc gtg aac aag aaa        795
Ile Gln Asn Gln Phe Cys His Leu Cys Lys Val Thr Val Asn Lys Lys           
            125                 130                 135                   

acc aaa cac tgc att tcc tgc aat aag tgt gtg tcc ggc ttc gac cac        843
Thr Lys His Cys Ile Ser Cys Asn Lys Cys Val Ser Gly Phe Asp His           
        140                 145                 150                       

cac tgc aaa tgg atc aac aac tgc gtg gga agc cgg aat tat tgg ttc        891
His Cys Lys Trp Ile Asn Asn Cys Val Gly Ser Arg Asn Tyr Trp Phe           
    155                 160                 165                           

ttc ttc agc act gtg gcc tcg gcc aca gct ggc atg ctc tgc ctg atc        939
Phe Phe Ser Thr Val Ala Ser Ala Thr Ala Gly Met Leu Cys Leu Ile           
170                 175                 180                 185           

gcc atc ctg ctg tat gtc ctc gtc cag tac ctc gtg aac ccc ggg gtg        987
Ala Ile Leu Leu Tyr Val Leu Val Gln Tyr Leu Val Asn Pro Gly Val           
                190                 195                 200               

ctc cgc acg gac ccc agg tat gaa gat gtc aag aat atg aac acg tgg       1035
Leu Arg Thr Asp Pro Arg Tyr Glu Asp Val Lys Asn Met Asn Thr Trp           
            205                 210                 215                   

ctg ctg ttc ctc ccc ctg ttc ccg gtg cag gtg cag acc ctg ata gtc       1083
Leu Leu Phe Leu Pro Leu Phe Pro Val Gln Val Gln Thr Leu Ile Val           
        220                 225                 230                       

gtg atc atc ggg atg ctc gtg ctc ctg ctg gac ttt ctt ggc ttg gtg       1131
Val Ile Ile Gly Met Leu Val Leu Leu Leu Asp Phe Leu Gly Leu Val           
    235                 240                 245                           

cac ctg ggc cag ctg ctc atc ttc cac atc tac ctg aag gcc aag aag       1179
His Leu Gly Gln Leu Leu Ile Phe His Ile Tyr Leu Lys Ala Lys Lys           
250                 255                 260                 265           

atg acc acc ttt gag tat ctc att aat aac cgc aaa gaa gag agt tca       1227
Met Thr Thr Phe Glu Tyr Leu Ile Asn Asn Arg Lys Glu Glu Ser Ser           
                270                 275                 280               

aaa cat caa gca gtg agg aaa gat cca tac gtg caa atg gac aaa gga       1275
Lys His Gln Ala Val Arg Lys Asp Pro Tyr Val Gln Met Asp Lys Gly           
            285                 290                 295                   

gtt ctc cag caa gga gct ggc gcc ctg ggc tca tct gca cag gga gtc       1323
Val Leu Gln Gln Gly Ala Gly Ala Leu Gly Ser Ser Ala Gln Gly Val           
        300                 305                 310                       

aaa gcc aag agc tcc ctg ctg att cac aag cac tta tgt cac ttc tgc       1371
Lys Ala Lys Ser Ser Leu Leu Ile His Lys His Leu Cys His Phe Cys           
    315                 320                 325                           

act tca gta aac cag gat ggg gat tcg acg gca cgg gaa ggg gat gaa       1419
Thr Ser Val Asn Gln Asp Gly Asp Ser Thr Ala Arg Glu Gly Asp Glu           
330                 335                 340                 345           

gac ccg tgt cca tct gca ctt gga gcc aag gcc agg aac tcc cgg ctg       1467
Asp Pro Cys Pro Ser Ala Leu Gly Ala Lys Ala Arg Asn Ser Arg Leu           
                350                 355                 360               

att tgc agg cgc ctg tgt cag ttc tcc act cgt gta cac cca gac ggg       1515
Ile Cys Arg Arg Leu Cys Gln Phe Ser Thr Arg Val His Pro Asp Gly           
            365                 370                 375                   

ggc tcg atg gca cag gaa gca gat gat gcc ccg agt ata tct aca ctt       1563
Gly Ser Met Ala Gln Glu Ala Asp Asp Ala Pro Ser Ile Ser Thr Leu           
        380                 385                 390                       

ggg ctg caa caa gaa aca aca gag ccc atg aaa act gac agt gct gaa       1611
Gly Leu Gln Gln Glu Thr Thr Glu Pro Met Lys Thr Asp Ser Ala Glu           
    395                 400                 405                           

agt gaa gac tga gattcaggag ctcaggtgcc cctgtgatcc aggtcttcta           1663
Ser Glu Asp                                                               
410                                                                       

ccctgaaacc ccaccctcca tcaaggtcct gcctgtagag tctaccttgc aaagcctcct     1723

gctcctaccc atgctacagg ccaggaacca gagcccatca tctcagaggc ccctggatgt     1783

ccttcgaagg aaccaggacc ctcagagccc agcatccatc tctgtcatca tcttcatcac     1843

acccaaagaa gagccagcct tgcaggaggg tttacatctc caggaagatg ggctgccagc     1903

aactgcagag gatgcagcca cctgcttaac tgtgctgtcc agccagccag ccagctgcag     1963

ggcctcttgc tgcttaagag ctgatgggcc gggcatgttg gctcacacct gtgagcacag     2023

tactgggaaa tgggagcaca gtactaggaa atgggagcac agtactggga aatgggagca     2083

cagtactggg aaatgggggc tcacagcact gcaaaatggg agcacagtat tgggaaatgg     2143

gagcacagta ctgggaagtg ggagcacagt actgagaagt gggagcacag tactgagaaa     2203

tgggagtaca ctactgagaa atgggagcac agtactggga aatgggcata cagtactgag     2263

aaatgggagc acacagtact gggaaatggg agcacagtac tgggaaatgg gagcccacag     2323

tactgggaaa ggggagttca cagtactcgg aaatgggagc atagtactgg gaaatgggag     2383

cacagtactg ggaaatggga gcatagtact gggaaacccc agacctggat tctgagtttt     2443

tcagcctagc ccagacttct tatcttagta gacaaaaaga gtcaatacca gagaaccaga     2503

ggcatcctct gtattttaat gaactctgca ttttaatctg tttagtagtc attttttaaa     2563

agataatcag ttttccaaat atatctataa gttactacgt gcaaaaaaaa aaaaa          2618


<210>  716
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  716

Met Asp Thr Arg Ser Gly Ser Gln Cys Ser Val Thr Pro Glu Ala Ile 
1               5                   10                  15      


Leu Asn Asn Glu Lys Leu Val Leu Pro Pro Arg Ile Ser Arg Val Asn 
            20                  25                  30          


Gly Trp Ser Leu Pro Leu His Tyr Phe Gln Val Val Thr Trp Ala Val 
        35                  40                  45              


Phe Val Gly Leu Ser Ser Ala Thr Phe Gly Ile Phe Ile Pro Phe Leu 
    50                  55                  60                  


Pro His Ala Trp Lys Tyr Ile Ala Tyr Val Val Thr Gly Gly Ile Phe 
65                  70                  75                  80  


Ser Phe His Leu Val Val His Leu Ile Ala Ser Cys Ile Asp Pro Ala 
                85                  90                  95      


Asp Ser Asn Val Arg Leu Met Lys Asn Tyr Ser Gln Pro Met Pro Leu 
            100                 105                 110         


Phe Asp Arg Ser Lys His Ala His Val Ile Gln Asn Gln Phe Cys His 
        115                 120                 125             


Leu Cys Lys Val Thr Val Asn Lys Lys Thr Lys His Cys Ile Ser Cys 
    130                 135                 140                 


Asn Lys Cys Val Ser Gly Phe Asp His His Cys Lys Trp Ile Asn Asn 
145                 150                 155                 160 


Cys Val Gly Ser Arg Asn Tyr Trp Phe Phe Phe Ser Thr Val Ala Ser 
                165                 170                 175     


Ala Thr Ala Gly Met Leu Cys Leu Ile Ala Ile Leu Leu Tyr Val Leu 
            180                 185                 190         


Val Gln Tyr Leu Val Asn Pro Gly Val Leu Arg Thr Asp Pro Arg Tyr 
        195                 200                 205             


Glu Asp Val Lys Asn Met Asn Thr Trp Leu Leu Phe Leu Pro Leu Phe 
    210                 215                 220                 


Pro Val Gln Val Gln Thr Leu Ile Val Val Ile Ile Gly Met Leu Val 
225                 230                 235                 240 


Leu Leu Leu Asp Phe Leu Gly Leu Val His Leu Gly Gln Leu Leu Ile 
                245                 250                 255     


Phe His Ile Tyr Leu Lys Ala Lys Lys Met Thr Thr Phe Glu Tyr Leu 
            260                 265                 270         


Ile Asn Asn Arg Lys Glu Glu Ser Ser Lys His Gln Ala Val Arg Lys 
        275                 280                 285             


Asp Pro Tyr Val Gln Met Asp Lys Gly Val Leu Gln Gln Gly Ala Gly 
    290                 295                 300                 


Ala Leu Gly Ser Ser Ala Gln Gly Val Lys Ala Lys Ser Ser Leu Leu 
305                 310                 315                 320 


Ile His Lys His Leu Cys His Phe Cys Thr Ser Val Asn Gln Asp Gly 
                325                 330                 335     


Asp Ser Thr Ala Arg Glu Gly Asp Glu Asp Pro Cys Pro Ser Ala Leu 
            340                 345                 350         


Gly Ala Lys Ala Arg Asn Ser Arg Leu Ile Cys Arg Arg Leu Cys Gln 
        355                 360                 365             


Phe Ser Thr Arg Val His Pro Asp Gly Gly Ser Met Ala Gln Glu Ala 
    370                 375                 380                 


Asp Asp Ala Pro Ser Ile Ser Thr Leu Gly Leu Gln Gln Glu Thr Thr 
385                 390                 395                 400 


Glu Pro Met Lys Thr Asp Ser Ala Glu Ser Glu Asp 
                405                 410         


<210>  717
<211>  1885
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (49)..(1527)

<400>  717
ccgccgcagc cgccgcagca gcagcagccg ccgccccagg cccccccc atg gag ccc        57
                                                     Met Glu Pro          
                                                     1                    

gag gcc ccg gat tcc cgc aag agg ccc ctc gaa acg ccc ccc gag gtg        105
Glu Ala Pro Asp Ser Arg Lys Arg Pro Leu Glu Thr Pro Pro Glu Val           
    5                   10                  15                            

gtc tgc acc aag cgc agc aac acg gga gag gaa ggc gaa tac ttc ctg        153
Val Cys Thr Lys Arg Ser Asn Thr Gly Glu Glu Gly Glu Tyr Phe Leu           
20                  25                  30                  35            

aag gtg ctg atc ccc agc tac gcg gcg ggc tcc atc att ggc aag ggc        201
Lys Val Leu Ile Pro Ser Tyr Ala Ala Gly Ser Ile Ile Gly Lys Gly           
                40                  45                  50                

ggg cag acc atc gtg cag ctg cag aag gag acc gga gcc acc atc aag        249
Gly Gln Thr Ile Val Gln Leu Gln Lys Glu Thr Gly Ala Thr Ile Lys           
            55                  60                  65                    

ctc tcc aag tcc aaa gac ttc tac ccc gga acc aca gag cgg gta tgc        297
Leu Ser Lys Ser Lys Asp Phe Tyr Pro Gly Thr Thr Glu Arg Val Cys           
        70                  75                  80                        

cta gta cag ggc acg gca gag gcc ttg aat gct gtg cac agc ttt att        345
Leu Val Gln Gly Thr Ala Glu Ala Leu Asn Ala Val His Ser Phe Ile           
    85                  90                  95                            

gcc gag aag gtc cga gaa atc cca caa gcg atg acc aag cct gag gtg        393
Ala Glu Lys Val Arg Glu Ile Pro Gln Ala Met Thr Lys Pro Glu Val           
100                 105                 110                 115           

gtc aac atc ctt caa ccc caa acc acg atg aac ccc gac aga gcc aag        441
Val Asn Ile Leu Gln Pro Gln Thr Thr Met Asn Pro Asp Arg Ala Lys           
                120                 125                 130               

cag gcc aag ctg atc gtc ccc aac agc acg gcg ggc ctg atc atc ggc        489
Gln Ala Lys Leu Ile Val Pro Asn Ser Thr Ala Gly Leu Ile Ile Gly           
            135                 140                 145                   

aag gga ggc gcc acg gtg aaa gcc gtg atg gaa cag tca gga gca tgg        537
Lys Gly Gly Ala Thr Val Lys Ala Val Met Glu Gln Ser Gly Ala Trp           
        150                 155                 160                       

gtg cag ctg tcc cag aag ccg gag ggc atc aac ctg cag gag cgc gtg        585
Val Gln Leu Ser Gln Lys Pro Glu Gly Ile Asn Leu Gln Glu Arg Val           
    165                 170                 175                           

gtg acg gtc agc ggc gag ccc gag cag gtg cac aag gcc gtg agc gcc        633
Val Thr Val Ser Gly Glu Pro Glu Gln Val His Lys Ala Val Ser Ala           
180                 185                 190                 195           

atc gtg cag aag gta caa gaa gac ccc cag agc agc agc tgc ctc aac        681
Ile Val Gln Lys Val Gln Glu Asp Pro Gln Ser Ser Ser Cys Leu Asn           
                200                 205                 210               

atc agc tac gcc aac gtg gca ggc ccc gtg gcc aac tcc aac ccc acc        729
Ile Ser Tyr Ala Asn Val Ala Gly Pro Val Ala Asn Ser Asn Pro Thr           
            215                 220                 225                   

ggc tct ccg tac gcc agc ccc gcg gat gtg ctg cca gcc gcg gcc gca        777
Gly Ser Pro Tyr Ala Ser Pro Ala Asp Val Leu Pro Ala Ala Ala Ala           
        230                 235                 240                       

gcg tcg gcc gcc gcc gcc tcc ggc ctg ctg ggc ccc gcc ggg ctg gct        825
Ala Ser Ala Ala Ala Ala Ser Gly Leu Leu Gly Pro Ala Gly Leu Ala           
    245                 250                 255                           

ggc gtg ggg gcc ttt ccc gcc gcg ctg ccc gcc ttc tca ggc acc gac        873
Gly Val Gly Ala Phe Pro Ala Ala Leu Pro Ala Phe Ser Gly Thr Asp           
260                 265                 270                 275           

ctg ctg gcc atc agc acg gcg ctt aac acg ctg gca agt tac ggc tac        921
Leu Leu Ala Ile Ser Thr Ala Leu Asn Thr Leu Ala Ser Tyr Gly Tyr           
                280                 285                 290               

aac acc aac tcc ctg ggc ctg ggc ctc aac tcg gcc gca gct tcc ggc        969
Asn Thr Asn Ser Leu Gly Leu Gly Leu Asn Ser Ala Ala Ala Ser Gly           
            295                 300                 305                   

gtc ctg gcc gcc gtg gcc gcc ggg gcc aac cca gca gcc gcc gcc gcc       1017
Val Leu Ala Ala Val Ala Ala Gly Ala Asn Pro Ala Ala Ala Ala Ala           
        310                 315                 320                       

gcc aac ctc ctg gca tcc tac gcg ggc gag gcc ggg gcc ggg cca gcc       1065
Ala Asn Leu Leu Ala Ser Tyr Ala Gly Glu Ala Gly Ala Gly Pro Ala           
    325                 330                 335                           

gga ggg gcc gcc ccg ccg ccg ccc ccg cct ccc gga gcc ctg ggg tcc       1113
Gly Gly Ala Ala Pro Pro Pro Pro Pro Pro Pro Gly Ala Leu Gly Ser           
340                 345                 350                 355           

ttt gcg ttg gcc gca gcc gcc aac ggc tac ctc ggg gcc ggg gcg ggc       1161
Phe Ala Leu Ala Ala Ala Ala Asn Gly Tyr Leu Gly Ala Gly Ala Gly           
                360                 365                 370               

ggc ggg gcg ggc gga ggg ggc ggc ccg ctg gtg gcc gct gca gcc gcg       1209
Gly Gly Ala Gly Gly Gly Gly Gly Pro Leu Val Ala Ala Ala Ala Ala           
            375                 380                 385                   

gcc ggg gcg gcc ggg ggc ttc ctg acg gcg gag aag ctg gcg gct gag       1257
Ala Gly Ala Ala Gly Gly Phe Leu Thr Ala Glu Lys Leu Ala Ala Glu           
        390                 395                 400                       

agt gcc aag gag ctg gtg gag att gcg gtg cct gag aac ctg gtg gga       1305
Ser Ala Lys Glu Leu Val Glu Ile Ala Val Pro Glu Asn Leu Val Gly           
    405                 410                 415                           

gcc atc ctg ggg aag ggg ggc aag acg ttg gtg gag tac cag gag ctg       1353
Ala Ile Leu Gly Lys Gly Gly Lys Thr Leu Val Glu Tyr Gln Glu Leu           
420                 425                 430                 435           

acg ggc gct cgc atc cag atc tcc aag aag ggc gag ttc ctg cca ggc       1401
Thr Gly Ala Arg Ile Gln Ile Ser Lys Lys Gly Glu Phe Leu Pro Gly           
                440                 445                 450               

acg cgg aac cgg cgg gtc acc atc acg ggc agc ccc gcg gcc acg caa       1449
Thr Arg Asn Arg Arg Val Thr Ile Thr Gly Ser Pro Ala Ala Thr Gln           
            455                 460                 465                   

gcc gct caa tac ctc atc agt cag cgg gtc acc tac gag cag gga gtg       1497
Ala Ala Gln Tyr Leu Ile Ser Gln Arg Val Thr Tyr Glu Gln Gly Val           
        470                 475                 480                       

agg gcc tca aac ccc cag aaa gtg gga tga ggcctgtggt gtgtgctccc         1547
Arg Ala Ser Asn Pro Gln Lys Val Gly                                       
    485                 490                                               

acccttttct ctcctcccat ctcctcctct tccctctcct cctccccccc aactcctgac     1607

ctcagcttgg tgtagtcctg ctcctcttgg gatggggctg gggtaggccc gactgcaccc     1667

tccccttctg gtagtcatag gcaggattga gtgacggttg ggaagggggc tcagaagccc     1727

cctccccagc ccggaactga cccctccttc ctccctccct gtgcttggct gggcctgacc     1787

cttcctgtcc cagggcccag gtctgtgtga tatctgtata tattgcattt tgttgatttt     1847

aatagaaaac aaagcgttat tttctctttc aaaaaaaa                             1885


<210>  718
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  718

Met Glu Pro Glu Ala Pro Asp Ser Arg Lys Arg Pro Leu Glu Thr Pro 
1               5                   10                  15      


Pro Glu Val Val Cys Thr Lys Arg Ser Asn Thr Gly Glu Glu Gly Glu 
            20                  25                  30          


Tyr Phe Leu Lys Val Leu Ile Pro Ser Tyr Ala Ala Gly Ser Ile Ile 
        35                  40                  45              


Gly Lys Gly Gly Gln Thr Ile Val Gln Leu Gln Lys Glu Thr Gly Ala 
    50                  55                  60                  


Thr Ile Lys Leu Ser Lys Ser Lys Asp Phe Tyr Pro Gly Thr Thr Glu 
65                  70                  75                  80  


Arg Val Cys Leu Val Gln Gly Thr Ala Glu Ala Leu Asn Ala Val His 
                85                  90                  95      


Ser Phe Ile Ala Glu Lys Val Arg Glu Ile Pro Gln Ala Met Thr Lys 
            100                 105                 110         


Pro Glu Val Val Asn Ile Leu Gln Pro Gln Thr Thr Met Asn Pro Asp 
        115                 120                 125             


Arg Ala Lys Gln Ala Lys Leu Ile Val Pro Asn Ser Thr Ala Gly Leu 
    130                 135                 140                 


Ile Ile Gly Lys Gly Gly Ala Thr Val Lys Ala Val Met Glu Gln Ser 
145                 150                 155                 160 


Gly Ala Trp Val Gln Leu Ser Gln Lys Pro Glu Gly Ile Asn Leu Gln 
                165                 170                 175     


Glu Arg Val Val Thr Val Ser Gly Glu Pro Glu Gln Val His Lys Ala 
            180                 185                 190         


Val Ser Ala Ile Val Gln Lys Val Gln Glu Asp Pro Gln Ser Ser Ser 
        195                 200                 205             


Cys Leu Asn Ile Ser Tyr Ala Asn Val Ala Gly Pro Val Ala Asn Ser 
    210                 215                 220                 


Asn Pro Thr Gly Ser Pro Tyr Ala Ser Pro Ala Asp Val Leu Pro Ala 
225                 230                 235                 240 


Ala Ala Ala Ala Ser Ala Ala Ala Ala Ser Gly Leu Leu Gly Pro Ala 
                245                 250                 255     


Gly Leu Ala Gly Val Gly Ala Phe Pro Ala Ala Leu Pro Ala Phe Ser 
            260                 265                 270         


Gly Thr Asp Leu Leu Ala Ile Ser Thr Ala Leu Asn Thr Leu Ala Ser 
        275                 280                 285             


Tyr Gly Tyr Asn Thr Asn Ser Leu Gly Leu Gly Leu Asn Ser Ala Ala 
    290                 295                 300                 


Ala Ser Gly Val Leu Ala Ala Val Ala Ala Gly Ala Asn Pro Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Ala Asn Leu Leu Ala Ser Tyr Ala Gly Glu Ala Gly Ala 
                325                 330                 335     


Gly Pro Ala Gly Gly Ala Ala Pro Pro Pro Pro Pro Pro Pro Gly Ala 
            340                 345                 350         


Leu Gly Ser Phe Ala Leu Ala Ala Ala Ala Asn Gly Tyr Leu Gly Ala 
        355                 360                 365             


Gly Ala Gly Gly Gly Ala Gly Gly Gly Gly Gly Pro Leu Val Ala Ala 
    370                 375                 380                 


Ala Ala Ala Ala Gly Ala Ala Gly Gly Phe Leu Thr Ala Glu Lys Leu 
385                 390                 395                 400 


Ala Ala Glu Ser Ala Lys Glu Leu Val Glu Ile Ala Val Pro Glu Asn 
                405                 410                 415     


Leu Val Gly Ala Ile Leu Gly Lys Gly Gly Lys Thr Leu Val Glu Tyr 
            420                 425                 430         


Gln Glu Leu Thr Gly Ala Arg Ile Gln Ile Ser Lys Lys Gly Glu Phe 
        435                 440                 445             


Leu Pro Gly Thr Arg Asn Arg Arg Val Thr Ile Thr Gly Ser Pro Ala 
    450                 455                 460                 


Ala Thr Gln Ala Ala Gln Tyr Leu Ile Ser Gln Arg Val Thr Tyr Glu 
465                 470                 475                 480 


Gln Gly Val Arg Ala Ser Asn Pro Gln Lys Val Gly 
                485                 490         


<210>  719
<211>  2445
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (43)..(2247)

<400>  719
cgccgcggcg cggagtcccg gctgcgggat agaccgaggg cc atg gcc gcc tct          54
                                               Met Ala Ala Ser            
                                               1                          

ccc gga ccc gcc ggc gtt ggc ggc gcc gga gca gtc tac ggc tcc ggc        102
Pro Gly Pro Ala Gly Val Gly Gly Ala Gly Ala Val Tyr Gly Ser Gly           
5                   10                  15                  20            

tct tcg ggc ttc gcc ctc gac tcg gga ctg gag atc aaa act cgc tcg        150
Ser Ser Gly Phe Ala Leu Asp Ser Gly Leu Glu Ile Lys Thr Arg Ser           
                25                  30                  35                

gtg gag cag acg cta ctc ccg ctg gtt tct cag atc acc acg ctt att        198
Val Glu Gln Thr Leu Leu Pro Leu Val Ser Gln Ile Thr Thr Leu Ile           
            40                  45                  50                    

aat cat aaa gat aat acc aaa aag tct gat aaa act ctg caa gca att        246
Asn His Lys Asp Asn Thr Lys Lys Ser Asp Lys Thr Leu Gln Ala Ile           
        55                  60                  65                        

cag cgt gta gga caa gct gtc aac ttg gca gtt gga aga ttt gtt aaa        294
Gln Arg Val Gly Gln Ala Val Asn Leu Ala Val Gly Arg Phe Val Lys           
    70                  75                  80                            

gta gga gaa gct ata gcc aat gaa aac tgg gat ttg aaa gaa gaa ata        342
Val Gly Glu Ala Ile Ala Asn Glu Asn Trp Asp Leu Lys Glu Glu Ile           
85                  90                  95                  100           

aat att gct tgt att gaa gct aaa caa gca gga gaa aca att gca gca        390
Asn Ile Ala Cys Ile Glu Ala Lys Gln Ala Gly Glu Thr Ile Ala Ala           
                105                 110                 115               

ctt aca gac ata acc aac ttg aac cat ctg gaa tct gat ggg cag atc        438
Leu Thr Asp Ile Thr Asn Leu Asn His Leu Glu Ser Asp Gly Gln Ile           
            120                 125                 130                   

aca att ttt aca gac aaa aca gga gtg ata aag gct gca aga tta ctt        486
Thr Ile Phe Thr Asp Lys Thr Gly Val Ile Lys Ala Ala Arg Leu Leu           
        135                 140                 145                       

ctt tct tca gtg aca aaa gtg ttg ttg ctg gca gac cga gta gtc att        534
Leu Ser Ser Val Thr Lys Val Leu Leu Leu Ala Asp Arg Val Val Ile           
    150                 155                 160                           

aaa cag ata ata aca tca aga aat aag gtt ctc gca act atg gaa aga        582
Lys Gln Ile Ile Thr Ser Arg Asn Lys Val Leu Ala Thr Met Glu Arg           
165                 170                 175                 180           

cta gag aaa gtg aat agc ttt caa gag ttt gtc caa ata ttc agt caa        630
Leu Glu Lys Val Asn Ser Phe Gln Glu Phe Val Gln Ile Phe Ser Gln           
                185                 190                 195               

ttt gga aat gaa atg gtg gag ttt gca cat ctg agt gga gat aga caa        678
Phe Gly Asn Glu Met Val Glu Phe Ala His Leu Ser Gly Asp Arg Gln           
            200                 205                 210                   

aat gat ttg aaa gat gaa aag aaa aag gca aaa atg gca gca gct agg        726
Asn Asp Leu Lys Asp Glu Lys Lys Lys Ala Lys Met Ala Ala Ala Arg           
        215                 220                 225                       

gca gtt ctt gaa aag tgt aca atg atg ctt ctc aca gct tca aag aca        774
Ala Val Leu Glu Lys Cys Thr Met Met Leu Leu Thr Ala Ser Lys Thr           
    230                 235                 240                           

tgt ctg agg cat cct aac tgc gaa tca gcc cat aaa aac aaa gaa gga        822
Cys Leu Arg His Pro Asn Cys Glu Ser Ala His Lys Asn Lys Glu Gly           
245                 250                 255                 260           

gta ttt gac cgt atg aaa gtg gca ttg gat aag gtc att gaa att gtg        870
Val Phe Asp Arg Met Lys Val Ala Leu Asp Lys Val Ile Glu Ile Val           
                265                 270                 275               

act gac tgt aaa ccg aat gga gag act gac att tca tct atc agt att        918
Thr Asp Cys Lys Pro Asn Gly Glu Thr Asp Ile Ser Ser Ile Ser Ile           
            280                 285                 290                   

ttt act gga att aag gaa ttc aag atg aat att gaa gct ctt cgg gag        966
Phe Thr Gly Ile Lys Glu Phe Lys Met Asn Ile Glu Ala Leu Arg Glu           
        295                 300                 305                       

aat ctt tat ttt cag tcc aaa gag aac ctt tct gtg aca ttg gaa gtc       1014
Asn Leu Tyr Phe Gln Ser Lys Glu Asn Leu Ser Val Thr Leu Glu Val           
    310                 315                 320                           

atc ttg gag cgt atg gag gac ttt act gat tct gcc tac acc agc cat       1062
Ile Leu Glu Arg Met Glu Asp Phe Thr Asp Ser Ala Tyr Thr Ser His           
325                 330                 335                 340           

gag cac aga gaa cgc atc ttg gaa ctg tca act cag gcg aga atg gaa       1110
Glu His Arg Glu Arg Ile Leu Glu Leu Ser Thr Gln Ala Arg Met Glu           
                345                 350                 355               

ctg cag cag tta att tct gtg tgg att caa gct caa agc aag aaa aca       1158
Leu Gln Gln Leu Ile Ser Val Trp Ile Gln Ala Gln Ser Lys Lys Thr           
            360                 365                 370                   

aaa agc atc gct gaa gaa ctg gaa ctc agt att ttg aaa atc agt cac       1206
Lys Ser Ile Ala Glu Glu Leu Glu Leu Ser Ile Leu Lys Ile Ser His           
        375                 380                 385                       

agt ctt aat gaa ctt aag aaa gaa ctt cat agt aca gcg aca cag ctg       1254
Ser Leu Asn Glu Leu Lys Lys Glu Leu His Ser Thr Ala Thr Gln Leu           
    390                 395                 400                           

gca gca gat cta tta aaa tac cat gct gat cat gtg gtt cta aaa gca       1302
Ala Ala Asp Leu Leu Lys Tyr His Ala Asp His Val Val Leu Lys Ala           
405                 410                 415                 420           

tta aaa ctt act gga gta gaa gga aat tta gaa gct ttg gct gaa tat       1350
Leu Lys Leu Thr Gly Val Glu Gly Asn Leu Glu Ala Leu Ala Glu Tyr           
                425                 430                 435               

gcc tgt aaa ctc tct gaa cag aaa gag cag ctt gtt gag acc tgt cga       1398
Ala Cys Lys Leu Ser Glu Gln Lys Glu Gln Leu Val Glu Thr Cys Arg           
            440                 445                 450                   

ttg tta cga cac ata tct ggg aca gaa cct ctg gaa ata acc tgt ata       1446
Leu Leu Arg His Ile Ser Gly Thr Glu Pro Leu Glu Ile Thr Cys Ile           
        455                 460                 465                       

cat gca gag gag aca ttt cag gtg act ggc caa cag ata att tct gct       1494
His Ala Glu Glu Thr Phe Gln Val Thr Gly Gln Gln Ile Ile Ser Ala           
    470                 475                 480                           

gct gaa aca ttg aca ttg cat cca tct agt aaa att gct aaa gaa aac       1542
Ala Glu Thr Leu Thr Leu His Pro Ser Ser Lys Ile Ala Lys Glu Asn           
485                 490                 495                 500           

cta gat gta ttt tgt gaa gct tgg gaa tcc caa att agt gac atg tca       1590
Leu Asp Val Phe Cys Glu Ala Trp Glu Ser Gln Ile Ser Asp Met Ser           
                505                 510                 515               

aca ctg ctg aga gaa atc aat gac gtg ttt gaa gga aga cga gga gag       1638
Thr Leu Leu Arg Glu Ile Asn Asp Val Phe Glu Gly Arg Arg Gly Glu           
            520                 525                 530                   

aag tat ggc tac ctt tca ctt cca aag cca atg aag aat aat gca aac       1686
Lys Tyr Gly Tyr Leu Ser Leu Pro Lys Pro Met Lys Asn Asn Ala Asn           
        535                 540                 545                       

ctg aaa tca tta aag cca gac aag cct gac tct gag gag caa gcc aag       1734
Leu Lys Ser Leu Lys Pro Asp Lys Pro Asp Ser Glu Glu Gln Ala Lys           
    550                 555                 560                           

ata gca aag ctt gga ctt aag ctg ggt ttg ctc acc tct gac gct gac       1782
Ile Ala Lys Leu Gly Leu Lys Leu Gly Leu Leu Thr Ser Asp Ala Asp           
565                 570                 575                 580           

tgc gaa att gag aag tgg gaa gat cag gag aat gag att gtt caa tat       1830
Cys Glu Ile Glu Lys Trp Glu Asp Gln Glu Asn Glu Ile Val Gln Tyr           
                585                 590                 595               

gga cgg aac atg tcc agt atg gcc tat tct ctg tat tta ttt act aga       1878
Gly Arg Asn Met Ser Ser Met Ala Tyr Ser Leu Tyr Leu Phe Thr Arg           
            600                 605                 610                   

gga gag ggg cca ctg aaa act tcc cag gat tta att cat caa cta gag       1926
Gly Glu Gly Pro Leu Lys Thr Ser Gln Asp Leu Ile His Gln Leu Glu           
        615                 620                 625                       

gtt ttt gct gca gag ggt tta aag ctt act tcc agt gtt caa gct ttt       1974
Val Phe Ala Ala Glu Gly Leu Lys Leu Thr Ser Ser Val Gln Ala Phe           
    630                 635                 640                           

tca aaa cag ctg aaa gac gat gac aag ctt atg ctt ctc ctg gaa ata       2022
Ser Lys Gln Leu Lys Asp Asp Asp Lys Leu Met Leu Leu Leu Glu Ile           
645                 650                 655                 660           

aac aag cta att cct cta tgc cac cag ctc cag aca gta act aag act       2070
Asn Lys Leu Ile Pro Leu Cys His Gln Leu Gln Thr Val Thr Lys Thr           
                665                 670                 675               

tct ttg cag aat aaa gta ttt cta aag gtt gac aag tgt att acg aag       2118
Ser Leu Gln Asn Lys Val Phe Leu Lys Val Asp Lys Cys Ile Thr Lys           
            680                 685                 690                   

aca aga tcc atg atg gct ctc tta gtc caa ctt ctt tca ctt tgt tat       2166
Thr Arg Ser Met Met Ala Leu Leu Val Gln Leu Leu Ser Leu Cys Tyr           
        695                 700                 705                       

aaa ctg ctg aag aag ctt cag atg gaa aat aac gga tgg gtc tca gtt       2214
Lys Leu Leu Lys Lys Leu Gln Met Glu Asn Asn Gly Trp Val Ser Val           
    710                 715                 720                           

aca aat aag gac act atg gat agt aaa act tga gaagcttttg gggtcagatc     2267
Thr Asn Lys Asp Thr Met Asp Ser Lys Thr                                   
725                 730                                                   

tctggaacat catgtgatga agctgacatt tttaaaaatc aaatgatcct ttatcttttc     2327

agaaattcat caattttata aagaaaacaa tattgaaatt ttgctctatt ttctgatcat     2387

gaaactgatt gtaaagcttt ttgacaacta ataaatgtct tggtaattgc tagattct       2445


<210>  720
<211>  734
<212>  PRT
<213>  Homo sapiens

<400>  720

Met Ala Ala Ser Pro Gly Pro Ala Gly Val Gly Gly Ala Gly Ala Val 
1               5                   10                  15      


Tyr Gly Ser Gly Ser Ser Gly Phe Ala Leu Asp Ser Gly Leu Glu Ile 
            20                  25                  30          


Lys Thr Arg Ser Val Glu Gln Thr Leu Leu Pro Leu Val Ser Gln Ile 
        35                  40                  45              


Thr Thr Leu Ile Asn His Lys Asp Asn Thr Lys Lys Ser Asp Lys Thr 
    50                  55                  60                  


Leu Gln Ala Ile Gln Arg Val Gly Gln Ala Val Asn Leu Ala Val Gly 
65                  70                  75                  80  


Arg Phe Val Lys Val Gly Glu Ala Ile Ala Asn Glu Asn Trp Asp Leu 
                85                  90                  95      


Lys Glu Glu Ile Asn Ile Ala Cys Ile Glu Ala Lys Gln Ala Gly Glu 
            100                 105                 110         


Thr Ile Ala Ala Leu Thr Asp Ile Thr Asn Leu Asn His Leu Glu Ser 
        115                 120                 125             


Asp Gly Gln Ile Thr Ile Phe Thr Asp Lys Thr Gly Val Ile Lys Ala 
    130                 135                 140                 


Ala Arg Leu Leu Leu Ser Ser Val Thr Lys Val Leu Leu Leu Ala Asp 
145                 150                 155                 160 


Arg Val Val Ile Lys Gln Ile Ile Thr Ser Arg Asn Lys Val Leu Ala 
                165                 170                 175     


Thr Met Glu Arg Leu Glu Lys Val Asn Ser Phe Gln Glu Phe Val Gln 
            180                 185                 190         


Ile Phe Ser Gln Phe Gly Asn Glu Met Val Glu Phe Ala His Leu Ser 
        195                 200                 205             


Gly Asp Arg Gln Asn Asp Leu Lys Asp Glu Lys Lys Lys Ala Lys Met 
    210                 215                 220                 


Ala Ala Ala Arg Ala Val Leu Glu Lys Cys Thr Met Met Leu Leu Thr 
225                 230                 235                 240 


Ala Ser Lys Thr Cys Leu Arg His Pro Asn Cys Glu Ser Ala His Lys 
                245                 250                 255     


Asn Lys Glu Gly Val Phe Asp Arg Met Lys Val Ala Leu Asp Lys Val 
            260                 265                 270         


Ile Glu Ile Val Thr Asp Cys Lys Pro Asn Gly Glu Thr Asp Ile Ser 
        275                 280                 285             


Ser Ile Ser Ile Phe Thr Gly Ile Lys Glu Phe Lys Met Asn Ile Glu 
    290                 295                 300                 


Ala Leu Arg Glu Asn Leu Tyr Phe Gln Ser Lys Glu Asn Leu Ser Val 
305                 310                 315                 320 


Thr Leu Glu Val Ile Leu Glu Arg Met Glu Asp Phe Thr Asp Ser Ala 
                325                 330                 335     


Tyr Thr Ser His Glu His Arg Glu Arg Ile Leu Glu Leu Ser Thr Gln 
            340                 345                 350         


Ala Arg Met Glu Leu Gln Gln Leu Ile Ser Val Trp Ile Gln Ala Gln 
        355                 360                 365             


Ser Lys Lys Thr Lys Ser Ile Ala Glu Glu Leu Glu Leu Ser Ile Leu 
    370                 375                 380                 


Lys Ile Ser His Ser Leu Asn Glu Leu Lys Lys Glu Leu His Ser Thr 
385                 390                 395                 400 


Ala Thr Gln Leu Ala Ala Asp Leu Leu Lys Tyr His Ala Asp His Val 
                405                 410                 415     


Val Leu Lys Ala Leu Lys Leu Thr Gly Val Glu Gly Asn Leu Glu Ala 
            420                 425                 430         


Leu Ala Glu Tyr Ala Cys Lys Leu Ser Glu Gln Lys Glu Gln Leu Val 
        435                 440                 445             


Glu Thr Cys Arg Leu Leu Arg His Ile Ser Gly Thr Glu Pro Leu Glu 
    450                 455                 460                 


Ile Thr Cys Ile His Ala Glu Glu Thr Phe Gln Val Thr Gly Gln Gln 
465                 470                 475                 480 


Ile Ile Ser Ala Ala Glu Thr Leu Thr Leu His Pro Ser Ser Lys Ile 
                485                 490                 495     


Ala Lys Glu Asn Leu Asp Val Phe Cys Glu Ala Trp Glu Ser Gln Ile 
            500                 505                 510         


Ser Asp Met Ser Thr Leu Leu Arg Glu Ile Asn Asp Val Phe Glu Gly 
        515                 520                 525             


Arg Arg Gly Glu Lys Tyr Gly Tyr Leu Ser Leu Pro Lys Pro Met Lys 
    530                 535                 540                 


Asn Asn Ala Asn Leu Lys Ser Leu Lys Pro Asp Lys Pro Asp Ser Glu 
545                 550                 555                 560 


Glu Gln Ala Lys Ile Ala Lys Leu Gly Leu Lys Leu Gly Leu Leu Thr 
                565                 570                 575     


Ser Asp Ala Asp Cys Glu Ile Glu Lys Trp Glu Asp Gln Glu Asn Glu 
            580                 585                 590         


Ile Val Gln Tyr Gly Arg Asn Met Ser Ser Met Ala Tyr Ser Leu Tyr 
        595                 600                 605             


Leu Phe Thr Arg Gly Glu Gly Pro Leu Lys Thr Ser Gln Asp Leu Ile 
    610                 615                 620                 


His Gln Leu Glu Val Phe Ala Ala Glu Gly Leu Lys Leu Thr Ser Ser 
625                 630                 635                 640 


Val Gln Ala Phe Ser Lys Gln Leu Lys Asp Asp Asp Lys Leu Met Leu 
                645                 650                 655     


Leu Leu Glu Ile Asn Lys Leu Ile Pro Leu Cys His Gln Leu Gln Thr 
            660                 665                 670         


Val Thr Lys Thr Ser Leu Gln Asn Lys Val Phe Leu Lys Val Asp Lys 
        675                 680                 685             


Cys Ile Thr Lys Thr Arg Ser Met Met Ala Leu Leu Val Gln Leu Leu 
    690                 695                 700                 


Ser Leu Cys Tyr Lys Leu Leu Lys Lys Leu Gln Met Glu Asn Asn Gly 
705                 710                 715                 720 


Trp Val Ser Val Thr Asn Lys Asp Thr Met Asp Ser Lys Thr 
                725                 730                 


<210>  721
<211>  5435
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (184)..(1005)

<400>  721
ccgcctcgcg ccgagactag aagcgctgcg ggaagcaggg acagtggaga gggcgctgcg       60

ctcgggctac ccaatgcgtg gactatctgc cgccgctgtt cgtgcaatat gctggagctc      120

cagaacagct aaacggagtc gccacaccac tgtttgtgct ggatcgcagc gctgcctttc      180

ctt atg aag aag aca caa act tgg att ctc act tgc att tat ctt cag        228
    Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln           
    1               5                   10                  15            

ctg ctc cta ttt aat cct ctc gtc aaa act gaa ggg atc tgc agg aat        276
Leu Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn           
                20                  25                  30                

cgt gtg act aat aat gta aaa gac gtc act aaa ttg gtg gca aat ctt        324
Arg Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu           
            35                  40                  45                    

cca aaa gac tac atg ata acc ctc aaa tat gtc ccc ggg atg gat gtt        372
Pro Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val           
        50                  55                  60                        

ttg cca agt cat tgt tgg ata agc gag atg gta gta caa ttg tca gac        420
Leu Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp           
    65                  70                  75                            

agc ttg act gat ctt ctg gac aag ttt tca aat att tct gaa ggc ttg        468
Ser Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu           
80                  85                  90                  95            

agt aat tat tcc atc ata gac aaa ctt gtg aat ata gtg gat gac ctt        516
Ser Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu           
                100                 105                 110               

gtg gag tgc gtg aaa gaa aac tca tct aag gat cta aaa aaa tca ttc        564
Val Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe           
            115                 120                 125                   

aag agc cca gaa ccc agg ctc ttt act cct gaa gaa ttc ttt aga att        612
Lys Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile           
        130                 135                 140                       

ttt aat aga tcc att gat gcc ttc aag gac ttt gta gtg gca tct gaa        660
Phe Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu           
    145                 150                 155                           

act agt gat tgt gtg gtt tct tca aca tta agt cct gag aaa gat tcc        708
Thr Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Asp Ser           
160                 165                 170                 175           

aga gtc agt gtc aca aaa cca ttt atg tta ccc cct gtt gca gcc agc        756
Arg Val Ser Val Thr Lys Pro Phe Met Leu Pro Pro Val Ala Ala Ser           
                180                 185                 190               

tcc ctt agg aat gac agc agt agc agt aat agg aag gcc aaa aat ccc        804
Ser Leu Arg Asn Asp Ser Ser Ser Ser Asn Arg Lys Ala Lys Asn Pro           
            195                 200                 205                   

cct gga gac tcc agc cta cac tgg gca gcc atg gca ttg cca gca ttg        852
Pro Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu Pro Ala Leu           
        210                 215                 220                       

ttt tct ctt ata att ggc ttt gct ttt gga gcc tta tac tgg aag aag        900
Phe Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr Trp Lys Lys           
    225                 230                 235                           

aga cag cca agt ctt aca agg gca gtt gaa aat ata caa att aat gaa        948
Arg Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln Ile Asn Glu           
240                 245                 250                 255           

gag gat aat gag ata agt atg ttg caa gag aaa gag aga gag ttt caa        996
Glu Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg Glu Phe Gln           
                260                 265                 270               

gaa gtg taa ttgtggcttg tatcaacact gttactttcg tacattggct               1045
Glu Val                                                                   
                                                                          

ggtaacagtt catgtttgct tcataaatga agcagcttta aacaaattca tattctgtct     1105

ggagtgacag accacatctt tatctgttct tgctacccat gactttatat ggatgattca     1165

gaaattggaa cagaatgttt tactgtgaaa ctggcactga attaatcatc tataaagaag     1225

aacttgcatg gagcaggact ctattttaag gactgcggga cttgggtctc atttagaact     1285

tgcagctgat gttggaagag aaagcacgtg tctcagactg catgtaccat ttgcatggct     1345

ccagaaatgt ctaaatgctg aaaaaacacc tagctttatt cttcagatac aaactgcagc     1405

ctgtagttat cctggtctct gcaagtagat ttcagcttgg atagtgaggg taacaatttt     1465

tctcaaaggg atctggaaaa aatgtttaaa actcagtagt gtcagccact gtacagtgta     1525

gaaagcagtg ggaactgtga ttggatttgg caacatgtca gctttatagt tgccgattag     1585

tgatatgggt ctgatttcga tctcttcctg atgtaaacca tgctcaccca tatcccacta     1645

tacaaatgca aatggttgcc tggttccatt tatgcaaggg agccagtact gaattatgcc     1705

ttggcagagg ggagactcca aaagagtcat cgcaggaaga agttaagaac actgaacatc     1765

agaacagtct gccaagaagg acattggcat cctgggaaag tccgcctttt cccttgacca     1825

ctatagggtg tataaatcgt gtttgcaaaa tgtgttatga tgtgtttata ttctaaaact     1885

attacagagc tatgtaaagg gacttaggag aaaatgctga atgtaagatg gtcccatttc     1945

aatttccacc atgggagagc ctaaaaataa attatgacat ttagtatcta aggttagaaa     2005

accacgccca catgctaata tgggtgttga aaactaggtt acttataatg caaggaatca     2065

ggaaacttta gttatttata gtataatcac cattatctgt ttaaaggatc catttagtta     2125

aaatcgggca ctctatattc attaaggttt atgaattaaa aagaaagctt tatgtagtta     2185

tgcatgtcag tttgctattt aaaatgtgtg acagtgtttg tcatattaag agtgaatttg     2245

gcaggaattc ccaagatgga cattgtgctt ttaaactaga acttgtaaga cattatgtga     2305

atatcccttg ccaatttttt ttataataag aaaacatctg actaaagtca aagaatgatt     2365

tcttatggtt tattttgatg aaagttcttt taacatgtct tgaatgtaca cataaaggaa     2425

tccaaagctt tccattctaa cttaatcttt gtgataacat tattgccatg ttctacaacc     2485

gtaagatgac agttttcaat gtagtgacac aaaagggcat gaaaaactaa ctgctagctt     2545

tcctttcatt tcaaaagtcc aagaatttct agtatatttg gattttagct tctgttcaaa     2605

gcaaatccag atgcaactcc agtaagtggc ctttgctctt ttttgtacca aagagcccag     2665

atgattccta cagtcccttt cttctctaac atgctgtggt tccttaaata tgagtaattt     2725

ctctaagata taacccaggt gctttgagaa gctgcattaa ggtgttcagg ccctcagata     2785

tcacatggta cacttgatta gtaataaaac cagagatcaa tttaaattgc tgataggtcc     2845

tgtctcagtg tgtggcattg actgttttca ggaaaataga tacagattaa tatgagttat     2905

gcgtgtaggt tgtgtataga ttgagaagat agatacttct caatctagta gtttgattta     2965

tttaaccaat ggtttcagtt tgcttgagca tatgaaaatc ctgcttaatg tgcttaagag     3025

tataataaat gtgtactttt gtcctcaaac ctagtagctg ggttttaaca ctcatggaca     3085

tggtcttaat caatggagtt aaataaacaa attcagcaag ttattaaatc tgacatggta     3145

ggagagggga gatgtgtcct gcttattaaa tgtgttggtc cattgaaagt tacatggatt     3205

gccaattttt aaaacactaa agttgaataa aatgcatgaa caatagaaaa atgctgaaca     3265

ttattttgga tgctagctgc ttggacatta actgtgttat ttctgctttg agatgaaaat     3325

atatatttat ctttgcttat tttatcccag atgtgttctg aatatccttc ttcataaatc     3385

atggaaaact cactgctgag atagtaaacc atgaaatcgc cttttcagtt ggtgccatgt     3445

atctgacagt tccatcttgg aaggtttcaa aattaccttt taaaatgatc tcagaagtct     3505

gtagattctc aatgatactg aaagctttgc acctctttgg tagaaaccag gtctatttag     3565

aaaatggctt tatgataaat gttgcctcct gagtgataat gaagtgttcc tggatattgt     3625

attgtaattt aatgtgctta ccacactgcc acattttaat gagtcagaga aaaattaatt     3685

tttcttcaat acaataatag aacaagtagc ctattctctt aaaaagtatg tgaaaagaaa     3745

attatgaaaa aatatgcata cctaatgaag tattggtttt agtaagaatt aaatacattt     3805

cattgagctt taaagtactt tggagaaact ttggggcacg ttttcctact ctaattcaac     3865

taaagttata aataaagaga aaaactcatt cagaaatcat ggattttaaa aatattttac     3925

tgcagccaag ttttcatttc aaaatgtaat ttcagtttgg agcttttagg cattatgtat     3985

atttaaaaaa tatattcttc aaaaatgcat tttggcatgg tgggatggat gttgcaaaag     4045

atatccggag cctccagtct gtcattaact gatatggtaa atcacctctc ttctttgggt     4105

ctcaattttt tatttatcta tatggtaaac tcagagatca ctccttaggg gtgagtccta     4165

ttgcaatatg accgacaaag aagacaaaat agcattgaaa ctaacccata caaaatatcc     4225

aactctggat tctgtgaata agtatcttga ccataaaaag tcattgctgt tcttgtttct     4285

aatgtaaata gtgtccatta gtaaaagtga aattcagtct taagtagggt gaattggatc     4345

accatttaca caagagatgg ctttttcctt tgcttgaata aacattttgg atcacctcca     4405

aagaatgaaa accagtagta cgttttagtc atattagtca ggatgagaaa ctataagatg     4465

tgtgtaacat ttggaaatgc accaaagtga gcgtttaaat cttctcattt tattgaaaac     4525

taagagcaga aaatgtaaaa tgctcatgaa ggttttgaat gccaaaagat attttagaat     4585

caatttataa aggggtaatt cattaattac actttaaaat tggaaagtgg gataagaaat     4645

ctaaagtaaa ccagcttatc tttgaaacaa tattattttg aaattggctt taaaataaaa     4705

ccattcagat tgaaattcta attagctcat ttgtggagtt tgatcacaca attcataatg     4765

ttgctgcttt ccattaacta gtcttgaaat gcctttgttt gtaaaaataa aataatggta     4825

ctttcatttt ataacaaggt gtttttttca agaaataatc catgctaaaa tggatatttg     4885

tgatcctgaa atgtttacta agcattgtaa atttatttat aactgccatc tccaactaca     4945

tccttatgat gtttttaaca ataaaattaa aacaactgtt aaactaaaaa ccacaccgtt     5005

ttccagtact tgatctctga gctacaatac tcactaaata taattttcca atcaaaatat     5065

tctattctat attctaaggg ttaatatgtg attatagtgt ccacttgcca ccattttttt     5125

aaatcaatgg acttgaaaag tattaattta gatggatgcg cagatatacc ctcagttcag     5185

tcatagattg gagtttgcat ataataatgt aaatgtatgt cgacactatt ctaaatagtt     5245

ctattatgac tgaaatttaa ttaaataaaa aaggttgtaa aatgtgatgt gtatgtgtat     5305

atactgtatg tgtacttttt aaaataggtg tatgtcccaa ccctttttta tacaggtttg     5365

aatttaaaat tacatgatat atacatatac tttattgttc taaataaaga attttatgca     5425

ctctcataaa                                                            5435


<210>  722
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  722

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Asp Ser Arg 
                165                 170                 175     


Val Ser Val Thr Lys Pro Phe Met Leu Pro Pro Val Ala Ala Ser Ser 
            180                 185                 190         


Leu Arg Asn Asp Ser Ser Ser Ser Asn Arg Lys Ala Lys Asn Pro Pro 
        195                 200                 205             


Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu Pro Ala Leu Phe 
    210                 215                 220                 


Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr Trp Lys Lys Arg 
225                 230                 235                 240 


Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln Ile Asn Glu Glu 
                245                 250                 255     


Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg Glu Phe Gln Glu 
            260                 265                 270         


Val 
    


<210>  723
<211>  1832
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (50)..(1708)

<400>  723
gctttgcggc tgtcgtcgga gaggcatctg ggttcggact ggggccgcc atg ggg aaa       58
                                                      Met Gly Lys         
                                                      1                   

gtg aat gtg gcc aag ttg cgt tac atg agc cga gat gac ttc agg gtc        106
Val Asn Val Ala Lys Leu Arg Tyr Met Ser Arg Asp Asp Phe Arg Val           
    5                   10                  15                            

ttg acc gcg gtt gaa atg ggc atg aag aac cat gaa att gtt ccc ggc        154
Leu Thr Ala Val Glu Met Gly Met Lys Asn His Glu Ile Val Pro Gly           
20                  25                  30                  35            

agt ttg att gct tct ata gcc agc ctt aaa cat ggt ggc tgt aat aaa        202
Ser Leu Ile Ala Ser Ile Ala Ser Leu Lys His Gly Gly Cys Asn Lys           
                40                  45                  50                

gtt tta aga gaa tta gtg aaa cat aaa ctc ata gct tgg gag cgt acc        250
Val Leu Arg Glu Leu Val Lys His Lys Leu Ile Ala Trp Glu Arg Thr           
            55                  60                  65                    

aaa act gtc cag ggc tat cgg ttg aca aat gca gga tat gat tac cta        298
Lys Thr Val Gln Gly Tyr Arg Leu Thr Asn Ala Gly Tyr Asp Tyr Leu           
        70                  75                  80                        

gct ttg aaa aca ctt tct tct agg caa gta gtt gag tct gtt gga aac        346
Ala Leu Lys Thr Leu Ser Ser Arg Gln Val Val Glu Ser Val Gly Asn           
    85                  90                  95                            

cag atg ggt gtt ggc aaa gaa tca gat att tac att gtt gca aat gaa        394
Gln Met Gly Val Gly Lys Glu Ser Asp Ile Tyr Ile Val Ala Asn Glu           
100                 105                 110                 115           

gaa gga caa caa ttt gca tta aag ctt cac aga cta gga aga acc tcg        442
Glu Gly Gln Gln Phe Ala Leu Lys Leu His Arg Leu Gly Arg Thr Ser           
                120                 125                 130               

ttt cga aat ttg aaa aac aaa cgc gat tat cat aaa cat agg cac aat        490
Phe Arg Asn Leu Lys Asn Lys Arg Asp Tyr His Lys His Arg His Asn           
            135                 140                 145                   

gtg tct tgg ctt tat tta tct cgt ctc tct gcc atg aag gaa ttt gcc        538
Val Ser Trp Leu Tyr Leu Ser Arg Leu Ser Ala Met Lys Glu Phe Ala           
        150                 155                 160                       

tat atg aag gca ttg tat gag agg aaa ttt cca gtt cca aag cca att        586
Tyr Met Lys Ala Leu Tyr Glu Arg Lys Phe Pro Val Pro Lys Pro Ile           
    165                 170                 175                           

gat tac aat cgt cat gca gtg gtc atg gaa ctc ata aat ggt tat cca        634
Asp Tyr Asn Arg His Ala Val Val Met Glu Leu Ile Asn Gly Tyr Pro           
180                 185                 190                 195           

cta tgt cag ata cac cat gtt gaa gat cct gca tca gta tat gat gaa        682
Leu Cys Gln Ile His His Val Glu Asp Pro Ala Ser Val Tyr Asp Glu           
                200                 205                 210               

gct atg gaa cta att gtc aaa ctt gca aat cat ggg ctg att cat gga        730
Ala Met Glu Leu Ile Val Lys Leu Ala Asn His Gly Leu Ile His Gly           
            215                 220                 225                   

gat ttt aat gaa ttt aat ctc att ttg gat gaa agt gac cat atc acc        778
Asp Phe Asn Glu Phe Asn Leu Ile Leu Asp Glu Ser Asp His Ile Thr           
        230                 235                 240                       

atg att gat ttt cca cag atg gtt tca act tct cat ccc aat gct gag        826
Met Ile Asp Phe Pro Gln Met Val Ser Thr Ser His Pro Asn Ala Glu           
    245                 250                 255                           

tgg tat ttt gac aga gat gtt aaa tgc att aaa gat ttc ttt atg aaa        874
Trp Tyr Phe Asp Arg Asp Val Lys Cys Ile Lys Asp Phe Phe Met Lys           
260                 265                 270                 275           

cgt ttc agc tac gaa agt gag ctt ttt cca act ttt aag gat atc agg        922
Arg Phe Ser Tyr Glu Ser Glu Leu Phe Pro Thr Phe Lys Asp Ile Arg           
                280                 285                 290               

aga gaa gac act ctt gat gtg gag gtt tct gcc agt ggc tac aca aag        970
Arg Glu Asp Thr Leu Asp Val Glu Val Ser Ala Ser Gly Tyr Thr Lys           
            295                 300                 305                   

gaa atg cag gca gat gat gaa ctg ctt cat cca tta ggt cca gat gat       1018
Glu Met Gln Ala Asp Asp Glu Leu Leu His Pro Leu Gly Pro Asp Asp           
        310                 315                 320                       

aaa aat att gaa aca aaa gag gga tct gaa ttc tca ttt tca gat gga       1066
Lys Asn Ile Glu Thr Lys Glu Gly Ser Glu Phe Ser Phe Ser Asp Gly           
    325                 330                 335                           

gaa gtg gca gaa aaa gca gag gtt tac agg tca gaa aat gaa agt gaa       1114
Glu Val Ala Glu Lys Ala Glu Val Tyr Arg Ser Glu Asn Glu Ser Glu           
340                 345                 350                 355           

cgg aac tgt cta gaa gaa tca gag ggc tgc tat tgc aga tca tct gga       1162
Arg Asn Cys Leu Glu Glu Ser Glu Gly Cys Tyr Cys Arg Ser Ser Gly           
                360                 365                 370               

gac cct gaa caa ata aag gaa gac agt tta tca gaa gag agt gct gat       1210
Asp Pro Glu Gln Ile Lys Glu Asp Ser Leu Ser Glu Glu Ser Ala Asp           
            375                 380                 385                   

gca cgg agt ttt gaa atg act gaa ttc aat caa gct tta gaa gaa ata       1258
Ala Arg Ser Phe Glu Met Thr Glu Phe Asn Gln Ala Leu Glu Glu Ile           
        390                 395                 400                       

aaa ggg cag gtt gtt gaa aac aac tct gta act gaa ttt tct gag gag       1306
Lys Gly Gln Val Val Glu Asn Asn Ser Val Thr Glu Phe Ser Glu Glu           
    405                 410                 415                           

aaa aac aga act gaa aat tac aac agg caa gat ggt cag aga gtt caa       1354
Lys Asn Arg Thr Glu Asn Tyr Asn Arg Gln Asp Gly Gln Arg Val Gln           
420                 425                 430                 435           

gga gga gtc cct gct ggc tct gac gag tat gaa gat gaa tgc cct cat       1402
Gly Gly Val Pro Ala Gly Ser Asp Glu Tyr Glu Asp Glu Cys Pro His           
                440                 445                 450               

cta att gcc ttg tcg tca tta aat aga gaa ttc agg cct ttc aga gat       1450
Leu Ile Ala Leu Ser Ser Leu Asn Arg Glu Phe Arg Pro Phe Arg Asp           
            455                 460                 465                   

gaa gaa aat gtg gga gct atg aat cag tat aga aca aga act ctg agt       1498
Glu Glu Asn Val Gly Ala Met Asn Gln Tyr Arg Thr Arg Thr Leu Ser           
        470                 475                 480                       

atc act tct tca ggc agt gct gta agc tgt tca aca att cct cca gaa       1546
Ile Thr Ser Ser Gly Ser Ala Val Ser Cys Ser Thr Ile Pro Pro Glu           
    485                 490                 495                           

ctg gtg aaa cag aag gtg aaa cgt cag ttg aca aaa cag caa aaa tca       1594
Leu Val Lys Gln Lys Val Lys Arg Gln Leu Thr Lys Gln Gln Lys Ser           
500                 505                 510                 515           

gct gtc aga cgt cga ttg cag aaa gga gaa gca aat ata ttt acc aag       1642
Ala Val Arg Arg Arg Leu Gln Lys Gly Glu Ala Asn Ile Phe Thr Lys           
                520                 525                 530               

caa cgt agg gaa aac atg caa aat atc aaa tca agt ttg gaa gca gct       1690
Gln Arg Arg Glu Asn Met Gln Asn Ile Lys Ser Ser Leu Glu Ala Ala           
            535                 540                 545                   

agc ttt tgg gga gaa taa tatatttagg atcttggata tgtttaatat              1738
Ser Phe Trp Gly Glu                                                       
        550                                                               

attttttaaa gttactgtaa ttcctttttg agccctcatt tgtctttttt gagccaaggc     1798

tatcatatat taataaataa accctctttc atct                                 1832


<210>  724
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  724

Met Gly Lys Val Asn Val Ala Lys Leu Arg Tyr Met Ser Arg Asp Asp 
1               5                   10                  15      


Phe Arg Val Leu Thr Ala Val Glu Met Gly Met Lys Asn His Glu Ile 
            20                  25                  30          


Val Pro Gly Ser Leu Ile Ala Ser Ile Ala Ser Leu Lys His Gly Gly 
        35                  40                  45              


Cys Asn Lys Val Leu Arg Glu Leu Val Lys His Lys Leu Ile Ala Trp 
    50                  55                  60                  


Glu Arg Thr Lys Thr Val Gln Gly Tyr Arg Leu Thr Asn Ala Gly Tyr 
65                  70                  75                  80  


Asp Tyr Leu Ala Leu Lys Thr Leu Ser Ser Arg Gln Val Val Glu Ser 
                85                  90                  95      


Val Gly Asn Gln Met Gly Val Gly Lys Glu Ser Asp Ile Tyr Ile Val 
            100                 105                 110         


Ala Asn Glu Glu Gly Gln Gln Phe Ala Leu Lys Leu His Arg Leu Gly 
        115                 120                 125             


Arg Thr Ser Phe Arg Asn Leu Lys Asn Lys Arg Asp Tyr His Lys His 
    130                 135                 140                 


Arg His Asn Val Ser Trp Leu Tyr Leu Ser Arg Leu Ser Ala Met Lys 
145                 150                 155                 160 


Glu Phe Ala Tyr Met Lys Ala Leu Tyr Glu Arg Lys Phe Pro Val Pro 
                165                 170                 175     


Lys Pro Ile Asp Tyr Asn Arg His Ala Val Val Met Glu Leu Ile Asn 
            180                 185                 190         


Gly Tyr Pro Leu Cys Gln Ile His His Val Glu Asp Pro Ala Ser Val 
        195                 200                 205             


Tyr Asp Glu Ala Met Glu Leu Ile Val Lys Leu Ala Asn His Gly Leu 
    210                 215                 220                 


Ile His Gly Asp Phe Asn Glu Phe Asn Leu Ile Leu Asp Glu Ser Asp 
225                 230                 235                 240 


His Ile Thr Met Ile Asp Phe Pro Gln Met Val Ser Thr Ser His Pro 
                245                 250                 255     


Asn Ala Glu Trp Tyr Phe Asp Arg Asp Val Lys Cys Ile Lys Asp Phe 
            260                 265                 270         


Phe Met Lys Arg Phe Ser Tyr Glu Ser Glu Leu Phe Pro Thr Phe Lys 
        275                 280                 285             


Asp Ile Arg Arg Glu Asp Thr Leu Asp Val Glu Val Ser Ala Ser Gly 
    290                 295                 300                 


Tyr Thr Lys Glu Met Gln Ala Asp Asp Glu Leu Leu His Pro Leu Gly 
305                 310                 315                 320 


Pro Asp Asp Lys Asn Ile Glu Thr Lys Glu Gly Ser Glu Phe Ser Phe 
                325                 330                 335     


Ser Asp Gly Glu Val Ala Glu Lys Ala Glu Val Tyr Arg Ser Glu Asn 
            340                 345                 350         


Glu Ser Glu Arg Asn Cys Leu Glu Glu Ser Glu Gly Cys Tyr Cys Arg 
        355                 360                 365             


Ser Ser Gly Asp Pro Glu Gln Ile Lys Glu Asp Ser Leu Ser Glu Glu 
    370                 375                 380                 


Ser Ala Asp Ala Arg Ser Phe Glu Met Thr Glu Phe Asn Gln Ala Leu 
385                 390                 395                 400 


Glu Glu Ile Lys Gly Gln Val Val Glu Asn Asn Ser Val Thr Glu Phe 
                405                 410                 415     


Ser Glu Glu Lys Asn Arg Thr Glu Asn Tyr Asn Arg Gln Asp Gly Gln 
            420                 425                 430         


Arg Val Gln Gly Gly Val Pro Ala Gly Ser Asp Glu Tyr Glu Asp Glu 
        435                 440                 445             


Cys Pro His Leu Ile Ala Leu Ser Ser Leu Asn Arg Glu Phe Arg Pro 
    450                 455                 460                 


Phe Arg Asp Glu Glu Asn Val Gly Ala Met Asn Gln Tyr Arg Thr Arg 
465                 470                 475                 480 


Thr Leu Ser Ile Thr Ser Ser Gly Ser Ala Val Ser Cys Ser Thr Ile 
                485                 490                 495     


Pro Pro Glu Leu Val Lys Gln Lys Val Lys Arg Gln Leu Thr Lys Gln 
            500                 505                 510         


Gln Lys Ser Ala Val Arg Arg Arg Leu Gln Lys Gly Glu Ala Asn Ile 
        515                 520                 525             


Phe Thr Lys Gln Arg Arg Glu Asn Met Gln Asn Ile Lys Ser Ser Leu 
    530                 535                 540                 


Glu Ala Ala Ser Phe Trp Gly Glu 
545                 550         


<210>  725
<211>  1823
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (135)..(1589)

<400>  725
cctgggcggg ccctgcgtca ggttgcagtt tcacttttag ctctgggcac ctccagctcc       60

tgctcgccgg acggctccca gggagagcag acgcgccaga cgcgccaccc tcggggcgcc      120

gacggtcacg gagc atg ggg tcg gcc ttt gag cgg gta gtc cgg aga gtg        170
                Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val           
                1               5                   10                    

gtc cag gag ctg gac cat ggt ggg gag ttc atc cct gtg acc agc ctg        218
Val Gln Glu Leu Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu           
        15                  20                  25                        

cag agc tcc act ggc ttc cag ccc tac tgc ctg gtg gtt agg aag ccc        266
Gln Ser Ser Thr Gly Phe Gln Pro Tyr Cys Leu Val Val Arg Lys Pro           
    30                  35                  40                            

tca agc tca tgg ttc tgg aaa ccc cgt tat aag tgt gtc aac ctg tct        314
Ser Ser Ser Trp Phe Trp Lys Pro Arg Tyr Lys Cys Val Asn Leu Ser           
45                  50                  55                  60            

atc aag gac atc ctg gag ccg gat gcc gcg gaa cca gac gtg cag cgt        362
Ile Lys Asp Ile Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg           
                65                  70                  75                

ggc agg agc ttc cac ttc tac gat gcc atg gat ggg cag ata cag ggc        410
Gly Arg Ser Phe His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly           
            80                  85                  90                    

agc gtg gag ctg gca gcc cca gga cag gca aag atc gca ggc ggg gcc        458
Ser Val Glu Leu Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala           
        95                  100                 105                       

gcg gtg tct gac agc tcc agc acc tca atg aat gtg tac tcg ctg agt        506
Ala Val Ser Asp Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser           
    110                 115                 120                           

gtg gac cct aac acc tgg cag act ctg ctc cat gag agg cac ctg cgg        554
Val Asp Pro Asn Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg           
125                 130                 135                 140           

cag cca gaa cac aaa gtc ctg cag cag ctg cgc agc cgc ggg gac aac        602
Gln Pro Glu His Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn           
                145                 150                 155               

gtg tac gtg gtg act gag gtg cta cag aca cag aag gag gtg gaa gtc        650
Val Tyr Val Val Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val           
            160                 165                 170                   

acg cgc acc cac aag cgg gag ggc tcg ggc cgg ttt tcc ctg ccc gga        698
Thr Arg Thr His Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly           
        175                 180                 185                       

gcc acg tgc ttg cag ggt gag ggc cag ggc cat ctg agc cag aag aag        746
Ala Thr Cys Leu Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys           
    190                 195                 200                           

acg gtc acc atc ccc tca ggc agc acc ctc gca ttc cgg gtg gcc cag        794
Thr Val Thr Ile Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln           
205                 210                 215                 220           

ctg gtt att gac tct gac ttg gac gtc ctt ctc ttc ccg gat aag aag        842
Leu Val Ile Asp Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys           
                225                 230                 235               

cag agg acc ttc cag cca ccc gcg aca ggc cac aag cgt tcc acg agc        890
Gln Arg Thr Phe Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser           
            240                 245                 250                   

gaa ggc gcc tgg cca cag ctg ccc tct ggc ctc tcc atg atg agg tgc        938
Glu Gly Ala Trp Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys           
        255                 260                 265                       

ctc cac aac ttc ctg aca gat ggg gtc cct gcg gag ggg gcg ttc act        986
Leu His Asn Phe Leu Thr Asp Gly Val Pro Ala Glu Gly Ala Phe Thr           
    270                 275                 280                           

gaa gac ttc cag ggc cta cgg gca gag gtg gag acc atc tcc aag gaa       1034
Glu Asp Phe Gln Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu           
285                 290                 295                 300           

ctg gag ctt ttg gac aga gag ctg tgc cag ctg ctg ctg gag ggc ctg       1082
Leu Glu Leu Leu Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu           
                305                 310                 315               

gag ggg gtg ctg cgg gac cag ctg gcc ctg cga gcc ttg gag gag gcg       1130
Glu Gly Val Leu Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala           
            320                 325                 330                   

ctg gag cag ggc cag agc ctt ggg ccg gtg gag ccc ctg gac ggt cca       1178
Leu Glu Gln Gly Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro           
        335                 340                 345                       

gca ggt gct gtc ctg gag tgc ctg gtg ttg tcc tcc gga atg ctg gtg       1226
Ala Gly Ala Val Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val           
    350                 355                 360                           

ccg gaa ctc gct atc cct gtt gtc tac ctg ctg ggg gca ctg acc atg       1274
Pro Glu Leu Ala Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met           
365                 370                 375                 380           

ctg agt gaa acg cag cac aag ctg ctg gcg gag gcg ctg gag tcg cag       1322
Leu Ser Glu Thr Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln           
                385                 390                 395               

acc ctg ttg ggg ccg ctc gag ctg gtg ggc agc ctc ttg gag cag agt       1370
Thr Leu Leu Gly Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser           
            400                 405                 410                   

gcc ccg tgg cag gag cgc agc acc atg tcc ctg ccc ccc ggg ctc ctg       1418
Ala Pro Trp Gln Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu           
        415                 420                 425                       

ggg aac agc tgg ggc gaa gga gca ccg gcc tgg gtc ttg ctg gac gag       1466
Gly Asn Ser Trp Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu           
    430                 435                 440                           

tgt ggc cta gag ctg ggg gag gac act ccc cac gtg tgc tgg gag ccg       1514
Cys Gly Leu Glu Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro           
445                 450                 455                 460           

cag gcc cag ggc cgc atg tgt gca ctc tac gcc tcc ctg gca ctg cta       1562
Gln Ala Gln Gly Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu           
                465                 470                 475               

tca gga ctg agc cag gag ccc cac tag cctgtgcccg ggcatggcct             1609
Ser Gly Leu Ser Gln Glu Pro His                                           
            480                                                           

ggcagctctc cagcagggca gagtgtttgc ccaccagctg ctagccctag gaaggccagg     1669

agcccagtag ccatgtggcc agtctaccat ggggcccagg agttggggaa acacaataaa     1729

ggtggcatac gaaggaaaaa aaaaaaaaaa aaaaaaccaa aaaaaaaaaa aaaaaaaaaa     1789

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                 1823


<210>  726
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  726

Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      


Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          


Gly Phe Gln Pro Tyr Cys Leu Val Val Arg Lys Pro Ser Ser Ser Trp 
        35                  40                  45              


Phe Trp Lys Pro Arg Tyr Lys Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  


Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  


His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      


Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         


Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             


Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 


Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 


Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     


Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         


Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             


Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 


Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 


Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     


Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Phe 
            260                 265                 270         


Leu Thr Asp Gly Val Pro Ala Glu Gly Ala Phe Thr Glu Asp Phe Gln 
        275                 280                 285             


Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu Leu Glu Leu Leu 
    290                 295                 300                 


Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu Glu Gly Val Leu 
305                 310                 315                 320 


Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala Leu Glu Gln Gly 
                325                 330                 335     


Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro Ala Gly Ala Val 
            340                 345                 350         


Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val Pro Glu Leu Ala 
        355                 360                 365             


Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met Leu Ser Glu Thr 
    370                 375                 380                 


Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln Thr Leu Leu Gly 
385                 390                 395                 400 


Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser Ala Pro Trp Gln 
                405                 410                 415     


Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu Gly Asn Ser Trp 
            420                 425                 430         


Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu Cys Gly Leu Glu 
        435                 440                 445             


Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro Gln Ala Gln Gly 
    450                 455                 460                 


Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu Ser Gly Leu Ser 
465                 470                 475                 480 


Gln Glu Pro His 
                


<210>  727
<211>  2514
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (343)..(2139)

<400>  727
cctcgtgccg cagttctgcc accgtcactg agaagctcag cggtagcttt tgggaagcag       60

gacgttctca ccaggagagc gtcctctcga gatttctgct ccctccattc agggcgtttg      120

ggagccaccc cttcattttt taaaaaaagt atttctctgt gaccgacggc cggggccttc      180

tgacggtctg aggtcttgct tgggccagtc acctcctgtc acggtccgcg gaggggggaa      240

ggataagagg gcgaggagct catcgctcgc cacccccgtg ggcttcttgg gcgcaggtcg      300

gagctgggtg ggccggctcc ccggcccctg gcttgggcga cc atg tcc gca tcc         354
                                               Met Ser Ala Ser            
                                               1                          

gcc cag cag ctg gcg gag gag ctg cag atc ttc ggc cta gac tgc gag        402
Ala Gln Gln Leu Ala Glu Glu Leu Gln Ile Phe Gly Leu Asp Cys Glu           
5                   10                  15                  20            

gag gct cta att gag aaa ttg gta gag ctt tgt gtt cag tat gga cag        450
Glu Ala Leu Ile Glu Lys Leu Val Glu Leu Cys Val Gln Tyr Gly Gln           
                25                  30                  35                

aat gag gag gga atg gta ggc gag ctt ata gcc ttc tgc acc agc aca        498
Asn Glu Glu Gly Met Val Gly Glu Leu Ile Ala Phe Cys Thr Ser Thr           
            40                  45                  50                    

cat aaa gtt ggc ctt acc tca gag atc ctg aac tct ttt gag cat gag        546
His Lys Val Gly Leu Thr Ser Glu Ile Leu Asn Ser Phe Glu His Glu           
        55                  60                  65                        

ttt ctg agc aaa aga tta tcg aaa gcc agg cat agt acc tgc aag gac        594
Phe Leu Ser Lys Arg Leu Ser Lys Ala Arg His Ser Thr Cys Lys Asp           
    70                  75                  80                            

agt ggc cat gca gga gct aga gac att gtt tcc att caa gag cta att        642
Ser Gly His Ala Gly Ala Arg Asp Ile Val Ser Ile Gln Glu Leu Ile           
85                  90                  95                  100           

gaa gtg gaa gaa gaa gag gaa atc ctc ttg aac tct tac acc aca cct        690
Glu Val Glu Glu Glu Glu Glu Ile Leu Leu Asn Ser Tyr Thr Thr Pro           
                105                 110                 115               

tca aag ggt tct cag aag cga gct atc tct acc cca gaa acc ccc cta        738
Ser Lys Gly Ser Gln Lys Arg Ala Ile Ser Thr Pro Glu Thr Pro Leu           
            120                 125                 130                   

aca aaa agg agt gtg tca act cgt agc ccc cat cag cta ctc tca ccg        786
Thr Lys Arg Ser Val Ser Thr Arg Ser Pro His Gln Leu Leu Ser Pro           
        135                 140                 145                       

tca agt ttc tct cca agt gct act ccc tcc cag aaa tac aac tca cga        834
Ser Ser Phe Ser Pro Ser Ala Thr Pro Ser Gln Lys Tyr Asn Ser Arg           
    150                 155                 160                           

agt aac cga gga gaa gtg gtt acc tcc ttc ggc tta gca cag gga gta        882
Ser Asn Arg Gly Glu Val Val Thr Ser Phe Gly Leu Ala Gln Gly Val           
165                 170                 175                 180           

tct tgg tct ggg aga gga gga gct gga aac atc agc ctg aag gtc ttg        930
Ser Trp Ser Gly Arg Gly Gly Ala Gly Asn Ile Ser Leu Lys Val Leu           
                185                 190                 195               

gga tgt cca gag gca cta act ggg agc tac aaa tcc atg ttt cag aag        978
Gly Cys Pro Glu Ala Leu Thr Gly Ser Tyr Lys Ser Met Phe Gln Lys           
            200                 205                 210                   

ctc cca gac att cga gaa gtt ctg acc tgt aag ata gaa gaa ctt ggc       1026
Leu Pro Asp Ile Arg Glu Val Leu Thr Cys Lys Ile Glu Glu Leu Gly           
        215                 220                 225                       

agc gaa ctc aag gaa cat tac aag att gaa gct ttc act cct ttg cta       1074
Ser Glu Leu Lys Glu His Tyr Lys Ile Glu Ala Phe Thr Pro Leu Leu           
    230                 235                 240                           

gcc cca gca cag gag cct gtc act ctg ctg ggc cag att ggc tgt gat       1122
Ala Pro Ala Gln Glu Pro Val Thr Leu Leu Gly Gln Ile Gly Cys Asp           
245                 250                 255                 260           

agc aac ggg aag ctg aac aac aag tca gtg att ctc gag gga gac cgg       1170
Ser Asn Gly Lys Leu Asn Asn Lys Ser Val Ile Leu Glu Gly Asp Arg           
                265                 270                 275               

gaa cat tcc tcg ggt gct caa att cca gtg gat tta tct gag ctt aag       1218
Glu His Ser Ser Gly Ala Gln Ile Pro Val Asp Leu Ser Glu Leu Lys           
            280                 285                 290                   

gaa tat tct ctg ttt cct gga cag gtt gta att atg gaa gga atc aac       1266
Glu Tyr Ser Leu Phe Pro Gly Gln Val Val Ile Met Glu Gly Ile Asn           
        295                 300                 305                       

acc act ggt agg aaa ctt gtt gcc acc aaa ctc tac gag ggt gtg cca       1314
Thr Thr Gly Arg Lys Leu Val Ala Thr Lys Leu Tyr Glu Gly Val Pro           
    310                 315                 320                           

ctt cca ttt tat cag ccc act gaa gag gat gca gac ttt gag caa agc       1362
Leu Pro Phe Tyr Gln Pro Thr Glu Glu Asp Ala Asp Phe Glu Gln Ser           
325                 330                 335                 340           

atg gtc ctg gtt gcc tgt gga cca tac acc aca tct gac agc atc acg       1410
Met Val Leu Val Ala Cys Gly Pro Tyr Thr Thr Ser Asp Ser Ile Thr           
                345                 350                 355               

tat gac ccc ctg ctt gac ctg att gct gtc atc aac cat gac cgg cca       1458
Tyr Asp Pro Leu Leu Asp Leu Ile Ala Val Ile Asn His Asp Arg Pro           
            360                 365                 370                   

gat gtc tgc atc ctg ttt ggc cct ttc ctg gat gct aag cat gaa cag       1506
Asp Val Cys Ile Leu Phe Gly Pro Phe Leu Asp Ala Lys His Glu Gln           
        375                 380                 385                       

gtg gag aat tgt cta ctg aca agt cca ttt gaa gac att ttc aag cag       1554
Val Glu Asn Cys Leu Leu Thr Ser Pro Phe Glu Asp Ile Phe Lys Gln           
    390                 395                 400                           

tgt cta cga aca att att gaa ggc aca aga agc tcc ggc tcc cac ctt       1602
Cys Leu Arg Thr Ile Ile Glu Gly Thr Arg Ser Ser Gly Ser His Leu           
405                 410                 415                 420           

gtc ttt gtc ccg tca ttg aga gat gtg cac cat gag cct gtg tac ccc       1650
Val Phe Val Pro Ser Leu Arg Asp Val His His Glu Pro Val Tyr Pro           
                425                 430                 435               

cag ccg cct ttc agc tac tcc gat ctg tct cga gag gac aaa aag caa       1698
Gln Pro Pro Phe Ser Tyr Ser Asp Leu Ser Arg Glu Asp Lys Lys Gln           
            440                 445                 450                   

gta cag ttt gtg tcc gag ccc tgc agc ctc tcc ata aac gga gtg atc       1746
Val Gln Phe Val Ser Glu Pro Cys Ser Leu Ser Ile Asn Gly Val Ile           
        455                 460                 465                       

ttc ggc ttg aca tcc aca gat ctg ctt ttc cac ctg ggg gcc gag gag       1794
Phe Gly Leu Thr Ser Thr Asp Leu Leu Phe His Leu Gly Ala Glu Glu           
    470                 475                 480                           

atc agt agt tct tcc gga act tca gac aga ttc agc cga ata ctc aag       1842
Ile Ser Ser Ser Ser Gly Thr Ser Asp Arg Phe Ser Arg Ile Leu Lys           
485                 490                 495                 500           

cac atc ttg acc cag agg agc tac tac cca ctc tac ccg ccc caa gaa       1890
His Ile Leu Thr Gln Arg Ser Tyr Tyr Pro Leu Tyr Pro Pro Gln Glu           
                505                 510                 515               

gac atg gcc att gac tat gag tcg ttc tat gtt tac gca cag ctg cct       1938
Asp Met Ala Ile Asp Tyr Glu Ser Phe Tyr Val Tyr Ala Gln Leu Pro           
            520                 525                 530                   

gtc acc cca gat gtc ctc atc atc ccg tca gag ctg agg tac ttc gtg       1986
Val Thr Pro Asp Val Leu Ile Ile Pro Ser Glu Leu Arg Tyr Phe Val           
        535                 540                 545                       

aag gat gtc ctc ggc tgt gtc tgt gtg aac cct ggg cgc ctt acc aaa       2034
Lys Asp Val Leu Gly Cys Val Cys Val Asn Pro Gly Arg Leu Thr Lys           
    550                 555                 560                           

ggg cag gtg gga ggc acc ttc gcc cga ctc tac ctt agg agg ccg gca       2082
Gly Gln Val Gly Gly Thr Phe Ala Arg Leu Tyr Leu Arg Arg Pro Ala           
565                 570                 575                 580           

gcg gac ggg gca gag agg cag agc cca tgc att gct gtg cag gtc gtc       2130
Ala Asp Gly Ala Glu Arg Gln Ser Pro Cys Ile Ala Val Gln Val Val           
                585                 590                 595               

agg atc tga ggcttctgtc ctctgctgtt ctctgctgtg tgggccctta               2179
Arg Ile                                                                   
                                                                          

aagtcttagc caagagccaa gacatagccc tgtgacaagg tgaacagttg ggtgggaaag     2239

gagagaggag ccagccaggg aggggcagct gcagtgacca ggcccagcag ggaggacttg     2299

tgcagccggg cctgcctctg agtggtgcct ctcctggaag gaagctcttg cttctcagtc     2359

catgctccgt gtccagaagt aagccagctg tggatcccgc ccactcagaa aaggcgagaa     2419

ggctttgtga ttttctacat gaatcaaaca cagaaacaac ttttggagaa attaaattct     2479

gagtgtgaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                2514


<210>  728
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  728

Met Ser Ala Ser Ala Gln Gln Leu Ala Glu Glu Leu Gln Ile Phe Gly 
1               5                   10                  15      


Leu Asp Cys Glu Glu Ala Leu Ile Glu Lys Leu Val Glu Leu Cys Val 
            20                  25                  30          


Gln Tyr Gly Gln Asn Glu Glu Gly Met Val Gly Glu Leu Ile Ala Phe 
        35                  40                  45              


Cys Thr Ser Thr His Lys Val Gly Leu Thr Ser Glu Ile Leu Asn Ser 
    50                  55                  60                  


Phe Glu His Glu Phe Leu Ser Lys Arg Leu Ser Lys Ala Arg His Ser 
65                  70                  75                  80  


Thr Cys Lys Asp Ser Gly His Ala Gly Ala Arg Asp Ile Val Ser Ile 
                85                  90                  95      


Gln Glu Leu Ile Glu Val Glu Glu Glu Glu Glu Ile Leu Leu Asn Ser 
            100                 105                 110         


Tyr Thr Thr Pro Ser Lys Gly Ser Gln Lys Arg Ala Ile Ser Thr Pro 
        115                 120                 125             


Glu Thr Pro Leu Thr Lys Arg Ser Val Ser Thr Arg Ser Pro His Gln 
    130                 135                 140                 


Leu Leu Ser Pro Ser Ser Phe Ser Pro Ser Ala Thr Pro Ser Gln Lys 
145                 150                 155                 160 


Tyr Asn Ser Arg Ser Asn Arg Gly Glu Val Val Thr Ser Phe Gly Leu 
                165                 170                 175     


Ala Gln Gly Val Ser Trp Ser Gly Arg Gly Gly Ala Gly Asn Ile Ser 
            180                 185                 190         


Leu Lys Val Leu Gly Cys Pro Glu Ala Leu Thr Gly Ser Tyr Lys Ser 
        195                 200                 205             


Met Phe Gln Lys Leu Pro Asp Ile Arg Glu Val Leu Thr Cys Lys Ile 
    210                 215                 220                 


Glu Glu Leu Gly Ser Glu Leu Lys Glu His Tyr Lys Ile Glu Ala Phe 
225                 230                 235                 240 


Thr Pro Leu Leu Ala Pro Ala Gln Glu Pro Val Thr Leu Leu Gly Gln 
                245                 250                 255     


Ile Gly Cys Asp Ser Asn Gly Lys Leu Asn Asn Lys Ser Val Ile Leu 
            260                 265                 270         


Glu Gly Asp Arg Glu His Ser Ser Gly Ala Gln Ile Pro Val Asp Leu 
        275                 280                 285             


Ser Glu Leu Lys Glu Tyr Ser Leu Phe Pro Gly Gln Val Val Ile Met 
    290                 295                 300                 


Glu Gly Ile Asn Thr Thr Gly Arg Lys Leu Val Ala Thr Lys Leu Tyr 
305                 310                 315                 320 


Glu Gly Val Pro Leu Pro Phe Tyr Gln Pro Thr Glu Glu Asp Ala Asp 
                325                 330                 335     


Phe Glu Gln Ser Met Val Leu Val Ala Cys Gly Pro Tyr Thr Thr Ser 
            340                 345                 350         


Asp Ser Ile Thr Tyr Asp Pro Leu Leu Asp Leu Ile Ala Val Ile Asn 
        355                 360                 365             


His Asp Arg Pro Asp Val Cys Ile Leu Phe Gly Pro Phe Leu Asp Ala 
    370                 375                 380                 


Lys His Glu Gln Val Glu Asn Cys Leu Leu Thr Ser Pro Phe Glu Asp 
385                 390                 395                 400 


Ile Phe Lys Gln Cys Leu Arg Thr Ile Ile Glu Gly Thr Arg Ser Ser 
                405                 410                 415     


Gly Ser His Leu Val Phe Val Pro Ser Leu Arg Asp Val His His Glu 
            420                 425                 430         


Pro Val Tyr Pro Gln Pro Pro Phe Ser Tyr Ser Asp Leu Ser Arg Glu 
        435                 440                 445             


Asp Lys Lys Gln Val Gln Phe Val Ser Glu Pro Cys Ser Leu Ser Ile 
    450                 455                 460                 


Asn Gly Val Ile Phe Gly Leu Thr Ser Thr Asp Leu Leu Phe His Leu 
465                 470                 475                 480 


Gly Ala Glu Glu Ile Ser Ser Ser Ser Gly Thr Ser Asp Arg Phe Ser 
                485                 490                 495     


Arg Ile Leu Lys His Ile Leu Thr Gln Arg Ser Tyr Tyr Pro Leu Tyr 
            500                 505                 510         


Pro Pro Gln Glu Asp Met Ala Ile Asp Tyr Glu Ser Phe Tyr Val Tyr 
        515                 520                 525             


Ala Gln Leu Pro Val Thr Pro Asp Val Leu Ile Ile Pro Ser Glu Leu 
    530                 535                 540                 


Arg Tyr Phe Val Lys Asp Val Leu Gly Cys Val Cys Val Asn Pro Gly 
545                 550                 555                 560 


Arg Leu Thr Lys Gly Gln Val Gly Gly Thr Phe Ala Arg Leu Tyr Leu 
                565                 570                 575     


Arg Arg Pro Ala Ala Asp Gly Ala Glu Arg Gln Ser Pro Cys Ile Ala 
            580                 585                 590         


Val Gln Val Val Arg Ile 
        595             


<210>  729
<211>  3160
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (284)..(2104)

<400>  729
ccgcagccgc cgagccgagc gcttgactat atatggtcaa agctgggggc gagccgcgcg       60

cgggaccgcg cttccgggtt cggggcgtcc gcaaccacag cgcgcagggc aggcgcgagc      120

tggcctctga gccccggcct cggaccgccc actccactcc cggcacgccc ggtgccgcct      180

tccggctcca gtccccgggc tcggcctcgg cgaggtgtaa ttcgcagcgc gggccggccc      240

cggaggctct cggcgagcgc ggcgcggtaa caagtgggcg agg atg ccg tac gag        295
                                                Met Pro Tyr Glu           
                                                1                         

atc aag aag gtg ttc gcc agc ctc ccg cag gtg gag agg ggc gtc tcc        343
Ile Lys Lys Val Phe Ala Ser Leu Pro Gln Val Glu Arg Gly Val Ser           
5                   10                  15                  20            

aag atc atc ggc ggc gac cct aag ggc aac aat ttt ctg tac acc aat        391
Lys Ile Ile Gly Gly Asp Pro Lys Gly Asn Asn Phe Leu Tyr Thr Asn           
                25                  30                  35                

gga aag tgc gtc atc cta agg aac atc gac aac cca gcc ctt gct gac        439
Gly Lys Cys Val Ile Leu Arg Asn Ile Asp Asn Pro Ala Leu Ala Asp           
            40                  45                  50                    

atc tac aca gag cac gcc cat cag gtg gtg gtg gcc aag tat gcg ccc        487
Ile Tyr Thr Glu His Ala His Gln Val Val Val Ala Lys Tyr Ala Pro           
        55                  60                  65                        

agc gga ttc tac att gcc tcc gga gat gtg tct ggg aag ctg agg atc        535
Ser Gly Phe Tyr Ile Ala Ser Gly Asp Val Ser Gly Lys Leu Arg Ile           
    70                  75                  80                            

tgg gat acc acg cag aag gag cac ctg ttg aag tat gag tac cag cct        583
Trp Asp Thr Thr Gln Lys Glu His Leu Leu Lys Tyr Glu Tyr Gln Pro           
85                  90                  95                  100           

ttc gct ggg aag atc aaa gac att gct tgg act gaa gac agt aag agg        631
Phe Ala Gly Lys Ile Lys Asp Ile Ala Trp Thr Glu Asp Ser Lys Arg           
                105                 110                 115               

atc gcc gtg gtc ggg gaa gga agg gag aag ttt gga gca gtc ttc ctc        679
Ile Ala Val Val Gly Glu Gly Arg Glu Lys Phe Gly Ala Val Phe Leu           
            120                 125                 130                   

tgg gat agt ggc tct tct gtg ggc gag att aca gga cac aac aaa gtc        727
Trp Asp Ser Gly Ser Ser Val Gly Glu Ile Thr Gly His Asn Lys Val           
        135                 140                 145                       

atc aac agc gtg gac atc aag cag agc cgg cca tac cgg ctg gcc acg        775
Ile Asn Ser Val Asp Ile Lys Gln Ser Arg Pro Tyr Arg Leu Ala Thr           
    150                 155                 160                           

gga agc gat gat aac tgc gcg gca ttc ttt gag gga ccc cca ttc aag        823
Gly Ser Asp Asp Asn Cys Ala Ala Phe Phe Glu Gly Pro Pro Phe Lys           
165                 170                 175                 180           

ttc aag ttc aca att ggc gac cac agc cgc ttt gtc aac tgt gtg cga        871
Phe Lys Phe Thr Ile Gly Asp His Ser Arg Phe Val Asn Cys Val Arg           
                185                 190                 195               

ttc tct cct gat ggg aac aga ttt gcc aca gcc agt gct gac ggc cag        919
Phe Ser Pro Asp Gly Asn Arg Phe Ala Thr Ala Ser Ala Asp Gly Gln           
            200                 205                 210                   

ata tac atc tat gac ggg aag act ggg gag aag gtg tgc gcg ctg ggc        967
Ile Tyr Ile Tyr Asp Gly Lys Thr Gly Glu Lys Val Cys Ala Leu Gly           
        215                 220                 225                       

gga agc aag gcc cac gac ggt ggg att tac gca att agt tgg agt ccc       1015
Gly Ser Lys Ala His Asp Gly Gly Ile Tyr Ala Ile Ser Trp Ser Pro           
    230                 235                 240                           

gac agc acc cat ttg ctt tct gct tct ggg gac aaa act tcc aag att       1063
Asp Ser Thr His Leu Leu Ser Ala Ser Gly Asp Lys Thr Ser Lys Ile           
245                 250                 255                 260           

tgg gac gtc agc gtg aac tcc gtg gtc agc aca ttt ccc atg ggc tcc       1111
Trp Asp Val Ser Val Asn Ser Val Val Ser Thr Phe Pro Met Gly Ser           
                265                 270                 275               

acg gtt ctg gac cag cag ctg ggc tgc cta tgg cag aag gac cac ctg       1159
Thr Val Leu Asp Gln Gln Leu Gly Cys Leu Trp Gln Lys Asp His Leu           
            280                 285                 290                   

ctc agt gtc tcc ctg tcc ggg tac atc aac tat ctg gac aga aac aac       1207
Leu Ser Val Ser Leu Ser Gly Tyr Ile Asn Tyr Leu Asp Arg Asn Asn           
        295                 300                 305                       

ccc agc aag ccc ctg cac gtc atc aag ggt cac agt aaa tcg atc cag       1255
Pro Ser Lys Pro Leu His Val Ile Lys Gly His Ser Lys Ser Ile Gln           
    310                 315                 320                           

tgt ctg acg gtg cat aaa aac ggc ggc aag tcc tac att tac tct ggg       1303
Cys Leu Thr Val His Lys Asn Gly Gly Lys Ser Tyr Ile Tyr Ser Gly           
325                 330                 335                 340           

agc cac gac gga cac att aat tac tgg gat tca gag acg ggg gag aac       1351
Ser His Asp Gly His Ile Asn Tyr Trp Asp Ser Glu Thr Gly Glu Asn           
                345                 350                 355               

gac tcc ttc gct ggg aaa ggc cac acg aac cag gtg tcc agg atg acc       1399
Asp Ser Phe Ala Gly Lys Gly His Thr Asn Gln Val Ser Arg Met Thr           
            360                 365                 370                   

gtg gat gag tcg ggg cag ctc atc agc tgc agc atg gac gac acc gtg       1447
Val Asp Glu Ser Gly Gln Leu Ile Ser Cys Ser Met Asp Asp Thr Val           
        375                 380                 385                       

cgg tac acc agc ctc atg ctg cgg gac tac agc gga caa gga gtt gtg       1495
Arg Tyr Thr Ser Leu Met Leu Arg Asp Tyr Ser Gly Gln Gly Val Val           
    390                 395                 400                           

aaa ctg gac gtt cag cca aag tgc gta gcc gtc ggc ccc ggg gga tac       1543
Lys Leu Asp Val Gln Pro Lys Cys Val Ala Val Gly Pro Gly Gly Tyr           
405                 410                 415                 420           

gcc gtg gtc gtg tgc att gga cag att gtc ctg ctg aag gat cag agg       1591
Ala Val Val Val Cys Ile Gly Gln Ile Val Leu Leu Lys Asp Gln Arg           
                425                 430                 435               

aag tgc ttc agc atc gac aac ccc ggc tac gag ccc gaa gtt gtg gca       1639
Lys Cys Phe Ser Ile Asp Asn Pro Gly Tyr Glu Pro Glu Val Val Ala           
            440                 445                 450                   

gtg cac ccc ggc ggg gac acg gtg gca att ggg ggt gtg gac ggc aac       1687
Val His Pro Gly Gly Asp Thr Val Ala Ile Gly Gly Val Asp Gly Asn           
        455                 460                 465                       

gtc cgc ctg tat tcc atc ctg ggc acc acg ctg aag gat gag ggc aag       1735
Val Arg Leu Tyr Ser Ile Leu Gly Thr Thr Leu Lys Asp Glu Gly Lys           
    470                 475                 480                           

ctc cta gag gcc aag ggc ccc gtg acc gac gtg gcc tac tcc cac gac       1783
Leu Leu Glu Ala Lys Gly Pro Val Thr Asp Val Ala Tyr Ser His Asp           
485                 490                 495                 500           

ggc gcc ttc ctc gcg gtg tgc gac gcc agc aag gtg gtc aca gtg ttc       1831
Gly Ala Phe Leu Ala Val Cys Asp Ala Ser Lys Val Val Thr Val Phe           
                505                 510                 515               

agc gtt gct gac ggc tac tcg gag aac aat gtt ttt tat gga cac cat       1879
Ser Val Ala Asp Gly Tyr Ser Glu Asn Asn Val Phe Tyr Gly His His           
            520                 525                 530                   

gca aaa atc gtc tgc ctg gcc tgg tcc cca gac aat gaa cac ttt gcc       1927
Ala Lys Ile Val Cys Leu Ala Trp Ser Pro Asp Asn Glu His Phe Ala           
        535                 540                 545                       

tcc ggt ggc atg gac atg atg gtg tat gtt tgg acc ctg agt gac ccg       1975
Ser Gly Gly Met Asp Met Met Val Tyr Val Trp Thr Leu Ser Asp Pro           
    550                 555                 560                           

gaa acc aga gtc aag atc caa gat gca cac cgg ctg cac cat gtc agc       2023
Glu Thr Arg Val Lys Ile Gln Asp Ala His Arg Leu His His Val Ser           
565                 570                 575                 580           

agc ctg gcc tgg ctg gac gag cac acg ctg gtc acg acc tcc cat gat       2071
Ser Leu Ala Trp Leu Asp Glu His Thr Leu Val Thr Thr Ser His Asp           
                585                 590                 595               

gcc tct gtc aag gag tgg aca atc acc tac tga ggagccccac ccccgcctct     2124
Ala Ser Val Lys Glu Trp Thr Ile Thr Tyr                                   
            600                 605                                       

ggatggaccg aatcagggac tagagtttaa ctgcagcgga acatgtcatt tctctatttc     2184

tgtgacgcgc ccccatgccc ccaccccacc acaagaggca ggagggccca gtcatgaccc     2244

tcgtctctgc agggtgtctg tacacgttct tctgaaagct ttagacagta acagtttgca     2304

catgaaaaat aaagcgagca cctaaacaat gtgtggagca taactaaaac ccacagccca     2364

accaaacctt gagaatgcga aacattccag aggcagtagc ctccaaagca cacagagccc     2424

ctggccccgc cgcggctctc actatctgtc aggggaggtt gtacaggtga atgagccggg     2484

gggctcatgt tcctgcctgc agaacatttc tgtactagtg agaagaggga atatgcattg     2544

cagttcagca aagccggaat tctgtgttga acagatgtct gtctccctag tgtgtgactc     2604

acaccttgtg gctgccttca gagcgccacc tccagatcag atggggacac acaacccctg     2664

gatatgtttc attgtcagat tttgtgcttg attttaagaa tggaattgtg ggtatctttc     2724

cttttttttt aatgtatctt aactgttgcc tgtcagtgtt tacaaactag tgcgttgacg     2784

gcaccgtgtc caagttttta gaacccttgt tagccagacc gaggtgtcct ggtcaccgtt     2844

tcaccatcat gctttgatgt tcccctgtct ttccctcttc tgctctcaag agcaaaggtt     2904

aatttaagga caaagatgaa gtcactgtaa actaatctgt cattgttttt accttccttt     2964

tctttttcag tgcagaaatt aaaagtaagt ataaagcacc gtgattggga gtgtttttgc     3024

gtgtgtcgga atcactggta aatgttggct gagaacaatc cctccccttg cacttgtgaa     3084

aacactttga gcgctttaag agattagcct gagaaataat taaatatctt ttctcttcaa     3144

aaaaaaaaaa aaaaaa                                                     3160


<210>  730
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  730

Met Pro Tyr Glu Ile Lys Lys Val Phe Ala Ser Leu Pro Gln Val Glu 
1               5                   10                  15      


Arg Gly Val Ser Lys Ile Ile Gly Gly Asp Pro Lys Gly Asn Asn Phe 
            20                  25                  30          


Leu Tyr Thr Asn Gly Lys Cys Val Ile Leu Arg Asn Ile Asp Asn Pro 
        35                  40                  45              


Ala Leu Ala Asp Ile Tyr Thr Glu His Ala His Gln Val Val Val Ala 
    50                  55                  60                  


Lys Tyr Ala Pro Ser Gly Phe Tyr Ile Ala Ser Gly Asp Val Ser Gly 
65                  70                  75                  80  


Lys Leu Arg Ile Trp Asp Thr Thr Gln Lys Glu His Leu Leu Lys Tyr 
                85                  90                  95      


Glu Tyr Gln Pro Phe Ala Gly Lys Ile Lys Asp Ile Ala Trp Thr Glu 
            100                 105                 110         


Asp Ser Lys Arg Ile Ala Val Val Gly Glu Gly Arg Glu Lys Phe Gly 
        115                 120                 125             


Ala Val Phe Leu Trp Asp Ser Gly Ser Ser Val Gly Glu Ile Thr Gly 
    130                 135                 140                 


His Asn Lys Val Ile Asn Ser Val Asp Ile Lys Gln Ser Arg Pro Tyr 
145                 150                 155                 160 


Arg Leu Ala Thr Gly Ser Asp Asp Asn Cys Ala Ala Phe Phe Glu Gly 
                165                 170                 175     


Pro Pro Phe Lys Phe Lys Phe Thr Ile Gly Asp His Ser Arg Phe Val 
            180                 185                 190         


Asn Cys Val Arg Phe Ser Pro Asp Gly Asn Arg Phe Ala Thr Ala Ser 
        195                 200                 205             


Ala Asp Gly Gln Ile Tyr Ile Tyr Asp Gly Lys Thr Gly Glu Lys Val 
    210                 215                 220                 


Cys Ala Leu Gly Gly Ser Lys Ala His Asp Gly Gly Ile Tyr Ala Ile 
225                 230                 235                 240 


Ser Trp Ser Pro Asp Ser Thr His Leu Leu Ser Ala Ser Gly Asp Lys 
                245                 250                 255     


Thr Ser Lys Ile Trp Asp Val Ser Val Asn Ser Val Val Ser Thr Phe 
            260                 265                 270         


Pro Met Gly Ser Thr Val Leu Asp Gln Gln Leu Gly Cys Leu Trp Gln 
        275                 280                 285             


Lys Asp His Leu Leu Ser Val Ser Leu Ser Gly Tyr Ile Asn Tyr Leu 
    290                 295                 300                 


Asp Arg Asn Asn Pro Ser Lys Pro Leu His Val Ile Lys Gly His Ser 
305                 310                 315                 320 


Lys Ser Ile Gln Cys Leu Thr Val His Lys Asn Gly Gly Lys Ser Tyr 
                325                 330                 335     


Ile Tyr Ser Gly Ser His Asp Gly His Ile Asn Tyr Trp Asp Ser Glu 
            340                 345                 350         


Thr Gly Glu Asn Asp Ser Phe Ala Gly Lys Gly His Thr Asn Gln Val 
        355                 360                 365             


Ser Arg Met Thr Val Asp Glu Ser Gly Gln Leu Ile Ser Cys Ser Met 
    370                 375                 380                 


Asp Asp Thr Val Arg Tyr Thr Ser Leu Met Leu Arg Asp Tyr Ser Gly 
385                 390                 395                 400 


Gln Gly Val Val Lys Leu Asp Val Gln Pro Lys Cys Val Ala Val Gly 
                405                 410                 415     


Pro Gly Gly Tyr Ala Val Val Val Cys Ile Gly Gln Ile Val Leu Leu 
            420                 425                 430         


Lys Asp Gln Arg Lys Cys Phe Ser Ile Asp Asn Pro Gly Tyr Glu Pro 
        435                 440                 445             


Glu Val Val Ala Val His Pro Gly Gly Asp Thr Val Ala Ile Gly Gly 
    450                 455                 460                 


Val Asp Gly Asn Val Arg Leu Tyr Ser Ile Leu Gly Thr Thr Leu Lys 
465                 470                 475                 480 


Asp Glu Gly Lys Leu Leu Glu Ala Lys Gly Pro Val Thr Asp Val Ala 
                485                 490                 495     


Tyr Ser His Asp Gly Ala Phe Leu Ala Val Cys Asp Ala Ser Lys Val 
            500                 505                 510         


Val Thr Val Phe Ser Val Ala Asp Gly Tyr Ser Glu Asn Asn Val Phe 
        515                 520                 525             


Tyr Gly His His Ala Lys Ile Val Cys Leu Ala Trp Ser Pro Asp Asn 
    530                 535                 540                 


Glu His Phe Ala Ser Gly Gly Met Asp Met Met Val Tyr Val Trp Thr 
545                 550                 555                 560 


Leu Ser Asp Pro Glu Thr Arg Val Lys Ile Gln Asp Ala His Arg Leu 
                565                 570                 575     


His His Val Ser Ser Leu Ala Trp Leu Asp Glu His Thr Leu Val Thr 
            580                 585                 590         


Thr Ser His Asp Ala Ser Val Lys Glu Trp Thr Ile Thr Tyr 
        595                 600                 605     


<210>  731
<211>  4077
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (229)..(3105)

<400>  731
agtagcgtcg cccgaggctg cagcagcgca tcccggggca tggcgcggcg ggggcgcgga       60

gggctcggtt cggagggggc cgggagcccg ggcgccctgg agtgaggagg accgggagct      120

ggctctggag gctgcggagg cgacgccgga gagaacgaag cctcggctgg gagcggatct      180

ttcgaagatg gtttggctgc cttggagatt tggagatctg atgccacg atg agg act       237
                                                     Met Arg Thr          
                                                     1                    

cac aca cgg ggg gct ccc agt gtg ttt ttc ata tat ttg ctt tgc ttt        285
His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu Leu Cys Phe           
    5                   10                  15                            

gtg tca gcc tac atc acc gac gag aac cca gaa gtt atg att ccc ttc        333
Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met Ile Pro Phe           
20                  25                  30                  35            

acc aat gcc aac tac gac agc cat ccc atg ctg tac ttc tcc agg gca        381
Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe Ser Arg Ala           
                40                  45                  50                

gaa gtg gcg gag ctg cag ctc agg gct gcc agc tcg cac gag cac att        429
Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His Glu His Ile           
            55                  60                  65                    

gca gcc cgc ctc acg gag gct gtg cac acg atg ctg tcc agc ccc ttg        477
Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser Ser Pro Leu           
        70                  75                  80                        

gaa tac ctc cct ccc tgg gat ccc aag gac tac agt gcc cgc tgg aat        525
Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala Arg Trp Asn           
    85                  90                  95                            

gaa att ttt gga aac aac ttg ggt gcc ttg gca atg ttc tgt gtg ctg        573
Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe Cys Val Leu           
100                 105                 110                 115           

tat cct gag aac att gaa gcc cga gac atg gcc aaa gac tac atg gag        621
Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp Tyr Met Glu           
                120                 125                 130               

agg atg gca gcg cag cct agt tgg ttg gtg aaa gat gct cct tgg gat        669
Arg Met Ala Ala Gln Pro Ser Trp Leu Val Lys Asp Ala Pro Trp Asp           
            135                 140                 145                   

gag gtc ccg ctt gct cac tcc ctg gtt ggt ttt gcc act gct tat gac        717
Glu Val Pro Leu Ala His Ser Leu Val Gly Phe Ala Thr Ala Tyr Asp           
        150                 155                 160                       

ttc ttg tac aac tac ctg agc aag aca caa cag gag aag ttt ctt gaa        765
Phe Leu Tyr Asn Tyr Leu Ser Lys Thr Gln Gln Glu Lys Phe Leu Glu           
    165                 170                 175                           

gtg att gcc aat gcc tca ggg tat atg tat gaa act tca tac agg aga        813
Val Ile Ala Asn Ala Ser Gly Tyr Met Tyr Glu Thr Ser Tyr Arg Arg           
180                 185                 190                 195           

gga tgg gga ttt caa tac ctg cac aat cat cag ccc acc aac tgt atg        861
Gly Trp Gly Phe Gln Tyr Leu His Asn His Gln Pro Thr Asn Cys Met           
                200                 205                 210               

gct ttg ctc acg gga agc cta gtc ctg atg aat caa gga tat ctt caa        909
Ala Leu Leu Thr Gly Ser Leu Val Leu Met Asn Gln Gly Tyr Leu Gln           
            215                 220                 225                   

gaa gcc tac tta tgg acc aaa caa gtt ctg acc atc atg gag aaa tct        957
Glu Ala Tyr Leu Trp Thr Lys Gln Val Leu Thr Ile Met Glu Lys Ser           
        230                 235                 240                       

ctg gtc ttg ctc agg gag gtg acg gat ggc tcc ctc tat gaa gga gtt       1005
Leu Val Leu Leu Arg Glu Val Thr Asp Gly Ser Leu Tyr Glu Gly Val           
    245                 250                 255                           

gcg tat ggc agc tac acc act aga tca ctc ttc caa tac atg ttt ctc       1053
Ala Tyr Gly Ser Tyr Thr Thr Arg Ser Leu Phe Gln Tyr Met Phe Leu           
260                 265                 270                 275           

gtc cag agg cac ttc aac atc aac cac ttt ggc cat ccg tgg ctt aaa       1101
Val Gln Arg His Phe Asn Ile Asn His Phe Gly His Pro Trp Leu Lys           
                280                 285                 290               

caa cac ttt gca ttt atg tat aga acc atc ctg cca ggg ttt caa agg       1149
Gln His Phe Ala Phe Met Tyr Arg Thr Ile Leu Pro Gly Phe Gln Arg           
            295                 300                 305                   

act gtg gct att gcg gac tca aat tac aac tgg ttt tat ggt cca gaa       1197
Thr Val Ala Ile Ala Asp Ser Asn Tyr Asn Trp Phe Tyr Gly Pro Glu           
        310                 315                 320                       

agc caa tta gtg ttc ctt gat aaa ttt gtc atg cgt aat ggc agt ggt       1245
Ser Gln Leu Val Phe Leu Asp Lys Phe Val Met Arg Asn Gly Ser Gly           
    325                 330                 335                           

aac tgg cta gct gac caa atc aga agg aac cgt gtg gtg gaa ggt cca       1293
Asn Trp Leu Ala Asp Gln Ile Arg Arg Asn Arg Val Val Glu Gly Pro           
340                 345                 350                 355           

gga aca cca tcc aaa ggg cag cgc tgg tgc act ctg cac aca gaa ttt       1341
Gly Thr Pro Ser Lys Gly Gln Arg Trp Cys Thr Leu His Thr Glu Phe           
                360                 365                 370               

ctc tgg tat gat ggc agc ttg aaa tcg gtt cct cct cca gac ttt ggc       1389
Leu Trp Tyr Asp Gly Ser Leu Lys Ser Val Pro Pro Pro Asp Phe Gly           
            375                 380                 385                   

acc cct aca ctg cat tat ttt gaa gac tgg ggt gtc gtg act tat gga       1437
Thr Pro Thr Leu His Tyr Phe Glu Asp Trp Gly Val Val Thr Tyr Gly           
        390                 395                 400                       

agt gca cta cct gca gaa atc aat aga tct ttc ctt tcc ttc aag tct       1485
Ser Ala Leu Pro Ala Glu Ile Asn Arg Ser Phe Leu Ser Phe Lys Ser           
    405                 410                 415                           

gga aaa ctg ggg gga cgt gca ata tat gac att gtc cac aga aac aaa       1533
Gly Lys Leu Gly Gly Arg Ala Ile Tyr Asp Ile Val His Arg Asn Lys           
420                 425                 430                 435           

tac aaa gat tgg atc aaa gga tgg aga aat ttt aat gca ggg cat gaa       1581
Tyr Lys Asp Trp Ile Lys Gly Trp Arg Asn Phe Asn Ala Gly His Glu           
                440                 445                 450               

cat cct gat caa aac tca ttt act ttt gct ccc aat ggt gtg cct ttc       1629
His Pro Asp Gln Asn Ser Phe Thr Phe Ala Pro Asn Gly Val Pro Phe           
            455                 460                 465                   

att act gag gct ctg tac ggg cca aag tac acc ttc ttc aac aat gtt       1677
Ile Thr Glu Ala Leu Tyr Gly Pro Lys Tyr Thr Phe Phe Asn Asn Val           
        470                 475                 480                       

ttg atg ttt tcc cca gct gtg tca aag agc tgc ttt tct ccc tgg gtg       1725
Leu Met Phe Ser Pro Ala Val Ser Lys Ser Cys Phe Ser Pro Trp Val           
    485                 490                 495                           

ggt cag gtc aca gaa gac tgc tca tca aaa tgg tct aaa tac aag cat       1773
Gly Gln Val Thr Glu Asp Cys Ser Ser Lys Trp Ser Lys Tyr Lys His           
500                 505                 510                 515           

gac ctg gca gct agt tgt cag ggg agg gtg gtt gca gca gag gag aaa       1821
Asp Leu Ala Ala Ser Cys Gln Gly Arg Val Val Ala Ala Glu Glu Lys           
                520                 525                 530               

aat ggg gtg gtt ttc atc cga gga gaa ggt gtg gga gct tat aac ccc       1869
Asn Gly Val Val Phe Ile Arg Gly Glu Gly Val Gly Ala Tyr Asn Pro           
            535                 540                 545                   

cag ctc aac ctg aag aat gtt cag agg aat ctc atc ctc cta cat cca       1917
Gln Leu Asn Leu Lys Asn Val Gln Arg Asn Leu Ile Leu Leu His Pro           
        550                 555                 560                       

cag ctg ctt ctc ctt gta gac caa ata cac ctg gga gag gag agt ccc       1965
Gln Leu Leu Leu Leu Val Asp Gln Ile His Leu Gly Glu Glu Ser Pro           
    565                 570                 575                           

ttg gag aca gca gcg agc ttc ttc cat aat gtg gat gtt cct ttt gag       2013
Leu Glu Thr Ala Ala Ser Phe Phe His Asn Val Asp Val Pro Phe Glu           
580                 585                 590                 595           

gag act gtg gta gat ggt gtc cat ggg gct ttc atc agg cag aga gat       2061
Glu Thr Val Val Asp Gly Val His Gly Ala Phe Ile Arg Gln Arg Asp           
                600                 605                 610               

ggt ctc tat aaa atg tac tgg atg gac gat act ggc tac agc gag aaa       2109
Gly Leu Tyr Lys Met Tyr Trp Met Asp Asp Thr Gly Tyr Ser Glu Lys           
            615                 620                 625                   

gca acc ttt gcc tca gtg aca tat cct cgg ggc tat ccc tac aac ggg       2157
Ala Thr Phe Ala Ser Val Thr Tyr Pro Arg Gly Tyr Pro Tyr Asn Gly           
        630                 635                 640                       

aca aac tat gtg aat gtc acc atg cac ctc cga agt ccc atc acc agg       2205
Thr Asn Tyr Val Asn Val Thr Met His Leu Arg Ser Pro Ile Thr Arg           
    645                 650                 655                           

gca gct tac ctc ttc ata ggg cca tct ata gat gtt cag agc ttc act       2253
Ala Ala Tyr Leu Phe Ile Gly Pro Ser Ile Asp Val Gln Ser Phe Thr           
660                 665                 670                 675           

gtc cac gga gac tct cag caa ctg gat gtg ttc ata gcc acc agc aaa       2301
Val His Gly Asp Ser Gln Gln Leu Asp Val Phe Ile Ala Thr Ser Lys           
                680                 685                 690               

cat gcc tac gcc aca tac ctg tgg aca ggt gag gcc aca gga cag tct       2349
His Ala Tyr Ala Thr Tyr Leu Trp Thr Gly Glu Ala Thr Gly Gln Ser           
            695                 700                 705                   

gcc ttt gca cag gtc att gct gat cgt cac aaa att ctg ttt gac cgg       2397
Ala Phe Ala Gln Val Ile Ala Asp Arg His Lys Ile Leu Phe Asp Arg           
        710                 715                 720                       

aat tca gcc atc aag agc agc att gtc cct gag gtg aag gac tat gct       2445
Asn Ser Ala Ile Lys Ser Ser Ile Val Pro Glu Val Lys Asp Tyr Ala           
    725                 730                 735                           

gct att gtg gaa cag aac ttg cag cat ttt aaa cca gtg ttt cag ctg       2493
Ala Ile Val Glu Gln Asn Leu Gln His Phe Lys Pro Val Phe Gln Leu           
740                 745                 750                 755           

ctg gag aag cag ata ctg tcc cga gtc cgg aac aca gct agc ttt agg       2541
Leu Glu Lys Gln Ile Leu Ser Arg Val Arg Asn Thr Ala Ser Phe Arg           
                760                 765                 770               

aag act gct gaa cgc ctg ctg aga ttt tca gat aag aga cag act gag       2589
Lys Thr Ala Glu Arg Leu Leu Arg Phe Ser Asp Lys Arg Gln Thr Glu           
            775                 780                 785                   

gag gcc att gac agg att ttt gcc ata tca cag caa cag cag cag caa       2637
Glu Ala Ile Asp Arg Ile Phe Ala Ile Ser Gln Gln Gln Gln Gln Gln           
        790                 795                 800                       

agc aag tca aag aaa aac cga agg gca ggc aaa cgc tat aaa ttt gtg       2685
Ser Lys Ser Lys Lys Asn Arg Arg Ala Gly Lys Arg Tyr Lys Phe Val           
    805                 810                 815                           

gat gct gtc cct gat att ttt gca cag att gaa gtc aat gag aaa aag       2733
Asp Ala Val Pro Asp Ile Phe Ala Gln Ile Glu Val Asn Glu Lys Lys           
820                 825                 830                 835           

att aga cag aaa gct cag att ttg gca cag aaa gaa cta ccc ata gat       2781
Ile Arg Gln Lys Ala Gln Ile Leu Ala Gln Lys Glu Leu Pro Ile Asp           
                840                 845                 850               

gaa gat gaa gaa atg aaa gac ctt tta gat ttt gca gat gta aca tac       2829
Glu Asp Glu Glu Met Lys Asp Leu Leu Asp Phe Ala Asp Val Thr Tyr           
            855                 860                 865                   

gag aaa cat aaa aat ggg ggc ttg att aaa ggc cgg ttt gga cag gca       2877
Glu Lys His Lys Asn Gly Gly Leu Ile Lys Gly Arg Phe Gly Gln Ala           
        870                 875                 880                       

cgg atg gtg aca act aca cac agc agg gcc cca tca ctg tct gct tcc       2925
Arg Met Val Thr Thr Thr His Ser Arg Ala Pro Ser Leu Ser Ala Ser           
    885                 890                 895                           

tat acc agg ttg ttc ctg att ctg aac att gct att ttc ttt gtc atg       2973
Tyr Thr Arg Leu Phe Leu Ile Leu Asn Ile Ala Ile Phe Phe Val Met           
900                 905                 910                 915           

ttg gca atg caa ctg act tat ttc cag agg gcc cag agc cta cat ggc       3021
Leu Ala Met Gln Leu Thr Tyr Phe Gln Arg Ala Gln Ser Leu His Gly           
                920                 925                 930               

caa aga tgt ctt tat gca gtt ctt ctc ata gat agc tgt att tta tta       3069
Gln Arg Cys Leu Tyr Ala Val Leu Leu Ile Asp Ser Cys Ile Leu Leu           
            935                 940                 945                   

tgg ttg tac tct tct tgt tcc caa tca cag tgt tag cactgaagct            3115
Trp Leu Tyr Ser Ser Cys Ser Gln Ser Gln Cys                               
        950                 955                                           

ataaattacc tggtcatttt gtgatcacaa gagtctatgc aaaaaaaaaa atttctttac     3175

cccagattat cagatttttt tccctcagat tcattttaac aaattaaggg aagatatttt     3235

gacacaagaa agcaggaacg tggagaaatt ggagcaggaa aagaaattat caaagcaata     3295

gaaatagctt ggtggtccta tggtgttttt ggaagtattt ggcattgcta attgagcagt     3355

ccatatagta ctacttttag aagaaacaaa aagtctattt tttaaagtaa tgttttttct     3415

tatgagaaaa aggtttagat agaattgggt tttattaata ttaatttaat gctattagca     3475

atttccatat actatattgt ggaaaagact gaagaataca attctgagaa atataaaaaa     3535

attttaatgg tatactcatg ttgaaagata aatgttgcta agtcctggta tgatggtgtg     3595

agcttccttg gggaagtact tcttgagtta tgtaactaac aggatgtttt actacagatc     3655

tggatggcta ttcagataac atggcaaaaa atgatagcag aagatcatta aaaacttaaa     3715

atatatttta ttagaaaaca tttatctatg aatgaatatt tccttgatgc tggtctctgc     3775

acacatatgc ttggttactt gcatgcattc attggttgtt caataagtga gatgattaca     3835

gataatactg tattttcctt atatggaaaa ccgttataga cccaataaca actaaacctt     3895

tcaaaagaaa atattttcta ttatgaatgt tgattttcat accaaagaag atggagagtc     3955

taaaatttgg atatgattct tatgtttttt taatagaaaa ccttcttcaa gtttattttc     4015

ctaaataaac atcataattg tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4075

aa                                                                    4077


<210>  732
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  732

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln Pro Ser Trp Leu Val Lys Asp Ala 
    130                 135                 140                 


Pro Trp Asp Glu Val Pro Leu Ala His Ser Leu Val Gly Phe Ala Thr 
145                 150                 155                 160 


Ala Tyr Asp Phe Leu Tyr Asn Tyr Leu Ser Lys Thr Gln Gln Glu Lys 
                165                 170                 175     


Phe Leu Glu Val Ile Ala Asn Ala Ser Gly Tyr Met Tyr Glu Thr Ser 
            180                 185                 190         


Tyr Arg Arg Gly Trp Gly Phe Gln Tyr Leu His Asn His Gln Pro Thr 
        195                 200                 205             


Asn Cys Met Ala Leu Leu Thr Gly Ser Leu Val Leu Met Asn Gln Gly 
    210                 215                 220                 


Tyr Leu Gln Glu Ala Tyr Leu Trp Thr Lys Gln Val Leu Thr Ile Met 
225                 230                 235                 240 


Glu Lys Ser Leu Val Leu Leu Arg Glu Val Thr Asp Gly Ser Leu Tyr 
                245                 250                 255     


Glu Gly Val Ala Tyr Gly Ser Tyr Thr Thr Arg Ser Leu Phe Gln Tyr 
            260                 265                 270         


Met Phe Leu Val Gln Arg His Phe Asn Ile Asn His Phe Gly His Pro 
        275                 280                 285             


Trp Leu Lys Gln His Phe Ala Phe Met Tyr Arg Thr Ile Leu Pro Gly 
    290                 295                 300                 


Phe Gln Arg Thr Val Ala Ile Ala Asp Ser Asn Tyr Asn Trp Phe Tyr 
305                 310                 315                 320 


Gly Pro Glu Ser Gln Leu Val Phe Leu Asp Lys Phe Val Met Arg Asn 
                325                 330                 335     


Gly Ser Gly Asn Trp Leu Ala Asp Gln Ile Arg Arg Asn Arg Val Val 
            340                 345                 350         


Glu Gly Pro Gly Thr Pro Ser Lys Gly Gln Arg Trp Cys Thr Leu His 
        355                 360                 365             


Thr Glu Phe Leu Trp Tyr Asp Gly Ser Leu Lys Ser Val Pro Pro Pro 
    370                 375                 380                 


Asp Phe Gly Thr Pro Thr Leu His Tyr Phe Glu Asp Trp Gly Val Val 
385                 390                 395                 400 


Thr Tyr Gly Ser Ala Leu Pro Ala Glu Ile Asn Arg Ser Phe Leu Ser 
                405                 410                 415     


Phe Lys Ser Gly Lys Leu Gly Gly Arg Ala Ile Tyr Asp Ile Val His 
            420                 425                 430         


Arg Asn Lys Tyr Lys Asp Trp Ile Lys Gly Trp Arg Asn Phe Asn Ala 
        435                 440                 445             


Gly His Glu His Pro Asp Gln Asn Ser Phe Thr Phe Ala Pro Asn Gly 
    450                 455                 460                 


Val Pro Phe Ile Thr Glu Ala Leu Tyr Gly Pro Lys Tyr Thr Phe Phe 
465                 470                 475                 480 


Asn Asn Val Leu Met Phe Ser Pro Ala Val Ser Lys Ser Cys Phe Ser 
                485                 490                 495     


Pro Trp Val Gly Gln Val Thr Glu Asp Cys Ser Ser Lys Trp Ser Lys 
            500                 505                 510         


Tyr Lys His Asp Leu Ala Ala Ser Cys Gln Gly Arg Val Val Ala Ala 
        515                 520                 525             


Glu Glu Lys Asn Gly Val Val Phe Ile Arg Gly Glu Gly Val Gly Ala 
    530                 535                 540                 


Tyr Asn Pro Gln Leu Asn Leu Lys Asn Val Gln Arg Asn Leu Ile Leu 
545                 550                 555                 560 


Leu His Pro Gln Leu Leu Leu Leu Val Asp Gln Ile His Leu Gly Glu 
                565                 570                 575     


Glu Ser Pro Leu Glu Thr Ala Ala Ser Phe Phe His Asn Val Asp Val 
            580                 585                 590         


Pro Phe Glu Glu Thr Val Val Asp Gly Val His Gly Ala Phe Ile Arg 
        595                 600                 605             


Gln Arg Asp Gly Leu Tyr Lys Met Tyr Trp Met Asp Asp Thr Gly Tyr 
    610                 615                 620                 


Ser Glu Lys Ala Thr Phe Ala Ser Val Thr Tyr Pro Arg Gly Tyr Pro 
625                 630                 635                 640 


Tyr Asn Gly Thr Asn Tyr Val Asn Val Thr Met His Leu Arg Ser Pro 
                645                 650                 655     


Ile Thr Arg Ala Ala Tyr Leu Phe Ile Gly Pro Ser Ile Asp Val Gln 
            660                 665                 670         


Ser Phe Thr Val His Gly Asp Ser Gln Gln Leu Asp Val Phe Ile Ala 
        675                 680                 685             


Thr Ser Lys His Ala Tyr Ala Thr Tyr Leu Trp Thr Gly Glu Ala Thr 
    690                 695                 700                 


Gly Gln Ser Ala Phe Ala Gln Val Ile Ala Asp Arg His Lys Ile Leu 
705                 710                 715                 720 


Phe Asp Arg Asn Ser Ala Ile Lys Ser Ser Ile Val Pro Glu Val Lys 
                725                 730                 735     


Asp Tyr Ala Ala Ile Val Glu Gln Asn Leu Gln His Phe Lys Pro Val 
            740                 745                 750         


Phe Gln Leu Leu Glu Lys Gln Ile Leu Ser Arg Val Arg Asn Thr Ala 
        755                 760                 765             


Ser Phe Arg Lys Thr Ala Glu Arg Leu Leu Arg Phe Ser Asp Lys Arg 
    770                 775                 780                 


Gln Thr Glu Glu Ala Ile Asp Arg Ile Phe Ala Ile Ser Gln Gln Gln 
785                 790                 795                 800 


Gln Gln Gln Ser Lys Ser Lys Lys Asn Arg Arg Ala Gly Lys Arg Tyr 
                805                 810                 815     


Lys Phe Val Asp Ala Val Pro Asp Ile Phe Ala Gln Ile Glu Val Asn 
            820                 825                 830         


Glu Lys Lys Ile Arg Gln Lys Ala Gln Ile Leu Ala Gln Lys Glu Leu 
        835                 840                 845             


Pro Ile Asp Glu Asp Glu Glu Met Lys Asp Leu Leu Asp Phe Ala Asp 
    850                 855                 860                 


Val Thr Tyr Glu Lys His Lys Asn Gly Gly Leu Ile Lys Gly Arg Phe 
865                 870                 875                 880 


Gly Gln Ala Arg Met Val Thr Thr Thr His Ser Arg Ala Pro Ser Leu 
                885                 890                 895     


Ser Ala Ser Tyr Thr Arg Leu Phe Leu Ile Leu Asn Ile Ala Ile Phe 
            900                 905                 910         


Phe Val Met Leu Ala Met Gln Leu Thr Tyr Phe Gln Arg Ala Gln Ser 
        915                 920                 925             


Leu His Gly Gln Arg Cys Leu Tyr Ala Val Leu Leu Ile Asp Ser Cys 
    930                 935                 940                 


Ile Leu Leu Trp Leu Tyr Ser Ser Cys Ser Gln Ser Gln Cys 
945                 950                 955             


<210>  733
<211>  7650
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (270)..(3392)

<400>  733
acacacacgc gccctcaccc gccaccgccg ccgcggccgc cgccgcaccc ggacagcgag       60

cggctgaggc cgccagggcc caaaggacag cggcccagac aggggctggc ggcccggccg      120

gccccggctc accgactcgg gcagcatcca cctgccccag ccaacaccct tctctcgccc      180

caggtccttt ctcagcctcc agctgggctg tccccaagct gagctgaggc tcttctcctc      240

cgatccccac ctctgcccgg acatccacc atg ggg aca gcc acc agg agg aag        293
                                Met Gly Thr Ala Thr Arg Arg Lys           
                                1               5                         

cca cac ctg ctg ctg gta gct gct gtg gcc ctt gtc tcc tct tca gct        341
Pro His Leu Leu Leu Val Ala Ala Val Ala Leu Val Ser Ser Ser Ala           
    10                  15                  20                            

tgg agt tca gcc ctg gga tcc caa acc acc ttc ggg cct gtc ttt gaa        389
Trp Ser Ser Ala Leu Gly Ser Gln Thr Thr Phe Gly Pro Val Phe Glu           
25                  30                  35                  40            

gac cag ccc ctc agt gtg cta ttc cca gag gag tcc acg gag gag cag        437
Asp Gln Pro Leu Ser Val Leu Phe Pro Glu Glu Ser Thr Glu Glu Gln           
                45                  50                  55                

gtg ttg ctg gca tgc cgc gcc cgg gcc agc cct cca gcc acc tat cgg        485
Val Leu Leu Ala Cys Arg Ala Arg Ala Ser Pro Pro Ala Thr Tyr Arg           
            60                  65                  70                    

tgg aag atg aat ggt acc gag atg aag ctg gag cca ggt tcc cgt cac        533
Trp Lys Met Asn Gly Thr Glu Met Lys Leu Glu Pro Gly Ser Arg His           
        75                  80                  85                        

cag ctg gtg ggg ggc aac ctg gtc atc atg aac ccc acc aag gca cag        581
Gln Leu Val Gly Gly Asn Leu Val Ile Met Asn Pro Thr Lys Ala Gln           
    90                  95                  100                           

gat gcc ggg gtc tac cag tgc ctg gcc tcc aac cca gtg ggc acc gtt        629
Asp Ala Gly Val Tyr Gln Cys Leu Ala Ser Asn Pro Val Gly Thr Val           
105                 110                 115                 120           

gtc agc agg gag gcc atc ctc cgc ttc ggc ttt ctg cag gaa ttc tcc        677
Val Ser Arg Glu Ala Ile Leu Arg Phe Gly Phe Leu Gln Glu Phe Ser           
                125                 130                 135               

aag gag gag cga gac cca gtg aaa gct cat gaa ggc tgg ggg gtg atg        725
Lys Glu Glu Arg Asp Pro Val Lys Ala His Glu Gly Trp Gly Val Met           
            140                 145                 150                   

ttg ccc tgt aac cca cct gcc cac tac cca ggc ttg tcc tac cgc tgg        773
Leu Pro Cys Asn Pro Pro Ala His Tyr Pro Gly Leu Ser Tyr Arg Trp           
        155                 160                 165                       

ctc ctc aac gag ttc ccc aac ttc atc ccg acg gac ggg cgt cac ttc        821
Leu Leu Asn Glu Phe Pro Asn Phe Ile Pro Thr Asp Gly Arg His Phe           
    170                 175                 180                           

gtg tcc cag acc aca ggg aac ctg tac att gcc cga acc aat gcc tca        869
Val Ser Gln Thr Thr Gly Asn Leu Tyr Ile Ala Arg Thr Asn Ala Ser           
185                 190                 195                 200           

gac ctg ggc aac tac tcc tgt ttg gcc acc agc cac atg gac ttc tcc        917
Asp Leu Gly Asn Tyr Ser Cys Leu Ala Thr Ser His Met Asp Phe Ser           
                205                 210                 215               

acc aag agc gtc ttc agc aag ttt gct cag ctc aac ctg gct gct gaa        965
Thr Lys Ser Val Phe Ser Lys Phe Ala Gln Leu Asn Leu Ala Ala Glu           
            220                 225                 230                   

gat acc cgg ctc ttt gca ccc agc atc aag gcc cgg ttc cca gca gag       1013
Asp Thr Arg Leu Phe Ala Pro Ser Ile Lys Ala Arg Phe Pro Ala Glu           
        235                 240                 245                       

acc tat gca ctg gtg ggg cag cag gtc acc ctg gag tgc ttc gcc ttt       1061
Thr Tyr Ala Leu Val Gly Gln Gln Val Thr Leu Glu Cys Phe Ala Phe           
    250                 255                 260                           

ggg aac cct gtc ccc cgg atc aag tgg cgc aaa gtg gac ggc tcc ctg       1109
Gly Asn Pro Val Pro Arg Ile Lys Trp Arg Lys Val Asp Gly Ser Leu           
265                 270                 275                 280           

tcc ccg cag tgg acc aca gct gag ccc acc ctg cag atc ccc agc gtc       1157
Ser Pro Gln Trp Thr Thr Ala Glu Pro Thr Leu Gln Ile Pro Ser Val           
                285                 290                 295               

agc ttt gag gat gag ggc acc tac gag tgt gag gcg gag aac tcc aag       1205
Ser Phe Glu Asp Glu Gly Thr Tyr Glu Cys Glu Ala Glu Asn Ser Lys           
            300                 305                 310                   

ggc cga gac acc gtg cag ggc cgc atc atc gtg cag gct cag cct gag       1253
Gly Arg Asp Thr Val Gln Gly Arg Ile Ile Val Gln Ala Gln Pro Glu           
        315                 320                 325                       

tgg cta aaa gtg atc tcg gac aca gag gct gac att ggc tcc aac ctg       1301
Trp Leu Lys Val Ile Ser Asp Thr Glu Ala Asp Ile Gly Ser Asn Leu           
    330                 335                 340                           

cgt tgg ggc tgt gca gcc gcc ggc aag ccc cgg cct aca gtg cgc tgg       1349
Arg Trp Gly Cys Ala Ala Ala Gly Lys Pro Arg Pro Thr Val Arg Trp           
345                 350                 355                 360           

ctg cgg aac ggg gag cct ctg gcc tcc cag aac cgg gtg gag gtg ttg       1397
Leu Arg Asn Gly Glu Pro Leu Ala Ser Gln Asn Arg Val Glu Val Leu           
                365                 370                 375               

gct ggg gac ctg cgg ttc tcc aag ctg agc ctg gaa gac tcg ggc atg       1445
Ala Gly Asp Leu Arg Phe Ser Lys Leu Ser Leu Glu Asp Ser Gly Met           
            380                 385                 390                   

tac cag tgt gtg gca gag aat aag cac ggt acc atc tac gcc agc gcc       1493
Tyr Gln Cys Val Ala Glu Asn Lys His Gly Thr Ile Tyr Ala Ser Ala           
        395                 400                 405                       

gag cta gcc gtg caa gca ctc gcc cct gac ttc agg ctg aat ccc gtg       1541
Glu Leu Ala Val Gln Ala Leu Ala Pro Asp Phe Arg Leu Asn Pro Val           
    410                 415                 420                           

agg cgt ctg atc ccc gcg gcc cgc ggg gga gag atc ctt atc ccc tgc       1589
Arg Arg Leu Ile Pro Ala Ala Arg Gly Gly Glu Ile Leu Ile Pro Cys           
425                 430                 435                 440           

cag ccc cgg gca gct cca aag gcc gtg gtg ctc tgg agc aaa ggc acg       1637
Gln Pro Arg Ala Ala Pro Lys Ala Val Val Leu Trp Ser Lys Gly Thr           
                445                 450                 455               

gag att ttg gtc aac agc agc aga gtg act gta act cca gat ggc acc       1685
Glu Ile Leu Val Asn Ser Ser Arg Val Thr Val Thr Pro Asp Gly Thr           
            460                 465                 470                   

ttg atc ata aga aac atc agc cgg tca gat gaa ggc aaa tac acc tgc       1733
Leu Ile Ile Arg Asn Ile Ser Arg Ser Asp Glu Gly Lys Tyr Thr Cys           
        475                 480                 485                       

ttt gct gag aac ttc atg ggc aaa gcc aac agc act gga atc cta tct       1781
Phe Ala Glu Asn Phe Met Gly Lys Ala Asn Ser Thr Gly Ile Leu Ser           
    490                 495                 500                           

gtg cga gat gca acc aaa atc act cta gcc ccc tca agt gcc gac atc       1829
Val Arg Asp Ala Thr Lys Ile Thr Leu Ala Pro Ser Ser Ala Asp Ile           
505                 510                 515                 520           

aac ttg ggt gac aac ctg acc cta cag tgc cat gcc tcc cac gac ccc       1877
Asn Leu Gly Asp Asn Leu Thr Leu Gln Cys His Ala Ser His Asp Pro           
                525                 530                 535               

acc atg gac ctc acc ttc acc tgg acc ctg gac gac ttc ccc atc gac       1925
Thr Met Asp Leu Thr Phe Thr Trp Thr Leu Asp Asp Phe Pro Ile Asp           
            540                 545                 550                   

ttt gat aag cct gga ggg cac tac cgg aga act aat gtg aag gag acc       1973
Phe Asp Lys Pro Gly Gly His Tyr Arg Arg Thr Asn Val Lys Glu Thr           
        555                 560                 565                       

att ggg gat ctg acc atc ctg aac gcc cag ctg cgc cat ggg ggg aag       2021
Ile Gly Asp Leu Thr Ile Leu Asn Ala Gln Leu Arg His Gly Gly Lys           
    570                 575                 580                           

tac acg tgc atg gcc cag acg gtg gtg gac agc gcg tcc aag gag gcc       2069
Tyr Thr Cys Met Ala Gln Thr Val Val Asp Ser Ala Ser Lys Glu Ala           
585                 590                 595                 600           

aca gtc ctg gtc cga ggt ccg cca ggt ccc cca gga ggt gtg gtg gtg       2117
Thr Val Leu Val Arg Gly Pro Pro Gly Pro Pro Gly Gly Val Val Val           
                605                 610                 615               

agg gac att ggc gac acc acc atc cag ctc agc tgg agc cgt ggc ttc       2165
Arg Asp Ile Gly Asp Thr Thr Ile Gln Leu Ser Trp Ser Arg Gly Phe           
            620                 625                 630                   

gac aac cac agc ccc atc gct aag tac acc ctg caa gct cgc act cca       2213
Asp Asn His Ser Pro Ile Ala Lys Tyr Thr Leu Gln Ala Arg Thr Pro           
        635                 640                 645                       

cct gca ggg aag tgg aag cag gtt cgg acc aat cct gca aac atc gag       2261
Pro Ala Gly Lys Trp Lys Gln Val Arg Thr Asn Pro Ala Asn Ile Glu           
    650                 655                 660                           

ggc aat gcc gag act gca cag gtg ctg ggc ctc acc ccc tgg atg gac       2309
Gly Asn Ala Glu Thr Ala Gln Val Leu Gly Leu Thr Pro Trp Met Asp           
665                 670                 675                 680           

tat gag ttc cgg gtc ata gcc agc aac att ctg ggc act ggg gag cct       2357
Tyr Glu Phe Arg Val Ile Ala Ser Asn Ile Leu Gly Thr Gly Glu Pro           
                685                 690                 695               

agt ggg ccc tcc agc aaa atc cgg acc agg gaa gca gcc ccc tcg gtg       2405
Ser Gly Pro Ser Ser Lys Ile Arg Thr Arg Glu Ala Ala Pro Ser Val           
            700                 705                 710                   

gca ccc tca gga ctc agc gga gga ggt gga gcc ccc gga gag ctc atc       2453
Ala Pro Ser Gly Leu Ser Gly Gly Gly Gly Ala Pro Gly Glu Leu Ile           
        715                 720                 725                       

gtc aac tgg acg ccc atg tca cgg gag tac cag aac gga gac ggc ttc       2501
Val Asn Trp Thr Pro Met Ser Arg Glu Tyr Gln Asn Gly Asp Gly Phe           
    730                 735                 740                           

ggc tac ctg ctg tcc ttc cgc agg cag ggc agc act cac tgg cag acc       2549
Gly Tyr Leu Leu Ser Phe Arg Arg Gln Gly Ser Thr His Trp Gln Thr           
745                 750                 755                 760           

gcc cgg gtg cct ggc gcc gat gcc cag tac ttt gtc tac agc aac gag       2597
Ala Arg Val Pro Gly Ala Asp Ala Gln Tyr Phe Val Tyr Ser Asn Glu           
                765                 770                 775               

agc gtc cgg ccc tac acg ccc ttt gag gtc aag atc cgc agc tac aac       2645
Ser Val Arg Pro Tyr Thr Pro Phe Glu Val Lys Ile Arg Ser Tyr Asn           
            780                 785                 790                   

cgc cgc ggg gat ggg ccc gag agc ctc act gca ctc gtg tac tca gct       2693
Arg Arg Gly Asp Gly Pro Glu Ser Leu Thr Ala Leu Val Tyr Ser Ala           
        795                 800                 805                       

gag gaa gag ccc agg gtg gcc cct acc aag gtg tgg gcc aaa ggg gtc       2741
Glu Glu Glu Pro Arg Val Ala Pro Thr Lys Val Trp Ala Lys Gly Val           
    810                 815                 820                           

tca tcc tca gag atg aac gtg acc tgg gaa ccc gtg cag cag gac atg       2789
Ser Ser Ser Glu Met Asn Val Thr Trp Glu Pro Val Gln Gln Asp Met           
825                 830                 835                 840           

aat ggt atc ctc ctg ggg tat gag atc cgc tac tgg aaa gct ggg gac       2837
Asn Gly Ile Leu Leu Gly Tyr Glu Ile Arg Tyr Trp Lys Ala Gly Asp           
                845                 850                 855               

aaa gaa gca gct gcg gac cga gtg agg aca gca ggg ctg gac acc agt       2885
Lys Glu Ala Ala Ala Asp Arg Val Arg Thr Ala Gly Leu Asp Thr Ser           
            860                 865                 870                   

gcc cga gtc agc ggc ctg cat ccc aac acc aag tac cat gtg acc gtg       2933
Ala Arg Val Ser Gly Leu His Pro Asn Thr Lys Tyr His Val Thr Val           
        875                 880                 885                       

agg gcc tac aac cgg gct ggc act ggg cct gcc agc cct tct gcc aac       2981
Arg Ala Tyr Asn Arg Ala Gly Thr Gly Pro Ala Ser Pro Ser Ala Asn           
    890                 895                 900                           

gcc acg acc atg aag ccc cct ccg cgg cga cct cct ggc aac atc tcc       3029
Ala Thr Thr Met Lys Pro Pro Pro Arg Arg Pro Pro Gly Asn Ile Ser           
905                 910                 915                 920           

tgg act ttc tca agc tct agt ctt agc att aag tgg gac cct gtg gtc       3077
Trp Thr Phe Ser Ser Ser Ser Leu Ser Ile Lys Trp Asp Pro Val Val           
                925                 930                 935               

cct ttc cga aat gag tct gca gtc acc ggc tat aag atg ctg tac cag       3125
Pro Phe Arg Asn Glu Ser Ala Val Thr Gly Tyr Lys Met Leu Tyr Gln           
            940                 945                 950                   

aat gac tta cac ctg act ccc acg ctc cac ctc acc ggc aag aac tgg       3173
Asn Asp Leu His Leu Thr Pro Thr Leu His Leu Thr Gly Lys Asn Trp           
        955                 960                 965                       

ata gaa atc cca gtg cct gaa gac att ggc cat gcc ctg gta caa att       3221
Ile Glu Ile Pro Val Pro Glu Asp Ile Gly His Ala Leu Val Gln Ile           
    970                 975                 980                           

cgg acc aca ggg ccc gga ggg gat ggg atc cct gca gaa gtc cac atc       3269
Arg Thr Thr Gly Pro Gly Gly Asp Gly Ile Pro Ala Glu Val His Ile           
985                 990                 995                 1000          

gtg agg aat gga ggc  aca agc atg atg gtg  gag aac atg gca gtc         3314
Val Arg Asn Gly Gly  Thr Ser Met Met Val  Glu Asn Met Ala Val             
                1005                 1010                 1015            

cgc cca gca cca cac  cct ggc acc gtc att  tcc cac tcc gtg gcg         3359
Arg Pro Ala Pro His  Pro Gly Thr Val Ile  Ser His Ser Val Ala             
                1020                 1025                 1030            

atg ctg atc ctc ata  ggc tcc ctg gag ctc  tga tcctggaacc              3402
Met Leu Ile Leu Ile  Gly Ser Leu Glu Leu                                  
                1035                 1040                                 

cctccctctg cgccgcagct ggacgccacc tccgacggac acagccagcc ccttcctgct     3462

gccaaggtgg cctgacactg tgccagagag tggctggttt taaataccta ctttaaacag     3522

tgcccttttt gtaggaggta ggatatttta tattctgccg caggatagaa cccacgcaag     3582

gattttcttt aaattgagag gcaccaggca gtaacttcca tgatgacact gacgcctata     3642

cctgagctct aggctgcctg gagggaagga acaggcccat gggaagaagg gggttttaaa     3702

aacatgtctt caactcagca gagatggccc tctgggaccc tatacggact ccgccacttg     3762

agagcagtcc taggcccggc aggaacacca gacatgaaca ggttgaagaa ctggagcgaa     3822

gtgcacacct caccatcctt cagtctaagg aagaagggca agccctggga ccaagagctc     3882

tcccgccttc tccctcgagc agcagcaagg accctgacgc tgtccccgat aactccctag     3942

gggctcctgc ctgcccaagc ggctgagaac cagcgccccg atgcctgagg ctgggagcct     4002

gagccccttc agctttgagg ggggtgatac tccaggctgt ttggggtggg agccaaaaag     4062

agttgagagg ccagggccct tggtggaaag gggcaccagc cttggtctga gatagtcaca     4122

acccaggtga cgatgccctc tcagccaaca ctgccaacct gaccctgtca tcccgattga     4182

cagcgccact tcaggtggct gggtgactaa agggcttgtc ttggtggggt ctcccacccc     4242

tccaagaccc attctgcaca gtccctccag ggtttgggca ggagatggcc aatcatgcgc     4302

ccacctctcc agtgctgcct gcagtcagct cggcctcccc gacctgcagc cccagactct     4362

gctctcccag cactgactca ctcctgcctg ggaggggaat gcagcattca tgctgtgtgt     4422

cctggtattg ggaggtttct gggaagggca gaggataaat gtggccctgc ctgctcccag     4482

gtatacctag gaccacctgg ccagatccgc tcccagacgg ccttggactg cttgcatttc     4542

cccggagaaa aaggggttaa taaatgggcc atcctttcct gagctctggg tatactacca     4602

gtcacagaac gtcagagctg gaagaagcct tagagctcaa cttcttcaag cccctcactt     4662

tacagatgag gaaatggagg tggtccagag agggtctggg attcccaagg tcacacagcc     4722

cagaagagat ggggctgggt taagaactcg agtcttccac ctttctgttc aaggctgttt     4782

gtctacccag aggaaggagg cactgctgaa tggctatggc ctggctaaga aggtgattag     4842

tcagtagggt gtgaaaattc tacttcaagg ggttcggatt ggtgatcatg gggattggca     4902

tggctgggtt cccgtccaag gtgtgggcag agcttctacc aaacttcaac atggagggct     4962

gacttgaagc tccctgtccc cctcactctt gccccaagaa aagaggccaa agcaagagca     5022

gattccctag gcaagagcag cagcacaact aggaaacccc aaagcccatg ctccgacagg     5082

tggcccttca cagggggcag cgggacaggc atcttgaagg gcatatgtcc tcggaagctc     5142

cgagcctgtt ttctgtagtt tatagttaga gctctatttt gttatggttt tttaaacttt     5202

taagtcctgc tctattttcc tgggcaggtt tatgttgatg tttacccact acaatttttt     5262

aaaaatataa gctcacatgc cttttccctg ccacagccaa acccccactg caccctaccc     5322

acccacccct agcccaggtc agctttcctg gagctggcta atgaaagcct cctcacctct     5382

tcccaaccct tacaagcaag ggtgctaggg gctcagctat acgaccattc tccctgacag     5442

ggagtccaaa cttggcctag catccctcct ggcccccctc tggccacgac ttggcctgtg     5502

cctggttctc tatcagaaag gggatgctga acaaaacctc cttccaagtt ttatccaatt     5562

cgttcctcat tgcctcgggc tgcgtcaggg gaagcagggg acaggtgtcc agttgctggg     5622

ccgagggagg agctggtttg gcataggacc taaccagtga agctagaggc tacagccact     5682

aaacttgctt caggccaacg atagttactc acaagtaagt accttaatgc taatgaggtc     5742

cactaaaaag gggaggaagg cagacctcct gggagaccca cgaagggttt ttagccaggg     5802

aaaactgagc cccaggaaaa cctaaccact gggcaggcag aatttgtttg agggatagaa     5862

cgacaacaaa ataaatgttc ctgcagcctg agatttcagg tagagtactg actaaggttt     5922

aataagacaa taggtgacct gaggacatgc aagcttgtaa aatgcaacag cctcctgcta     5982

gagtgacttg tacatgagct tgcttgcaga agactagatt agatgtttct caggatcccc     6042

tcctgcgcag gggttctctg attttcgtgt tctctgccca gatgggctgg gggagttgag     6102

agtgtgctta ttttcactgc gatcatgaga ccacagttct gggttatctc ctctcataca     6162

tcaagcccca gaggaggcgg caagaggaac agccacaaac aagtacttta ccccacagct     6222

tagtggccag taaacaccct ggggactagg aaaaggaacc aactgtaggc acctctccag     6282

ggcctaggga gacaagtgtc ctctcttctg catacatttg ggctcccctt acagagccct     6342

ttgccctggc tctctggtcc ttgttgctct aacagtccag atgtacaccc agcctcaggg     6402

ggaaggcagc tctctccaga cagagtctca gggcccagca aggtcaggtt atctgctttc     6462

attcagggca acaaatgata caaatggtgc cagggagtgg caaggccatg ggggtaggtg     6522

ggggtgtctt tttcttttca taaagtaaca acagacgaga ctgaggttaa acatcagaaa     6582

aaaacctctg gaatgacctt cctcattcca ggaggccctg gaataaggaa gaggcttctt     6642

tctgagggag ctttgaggaa ttttgacagc tgttgacatg ggatttggga aaggtgaagc     6702

tgtgactgga ggggcaggag atggtccaag tgtccatcca gagatgagac tcttagaatc     6762

aaagtgttca gcccaggaag tcttggagat cccaccttct gtggccctgc accttatggg     6822

aagccattaa gggggctcat ctaggaattc tggttacagc ccagtgctca tcccagcgta     6882

tgctgcctct ttagggcagc cccaagggcc agccagcctg tactctgggc aagagcccaa     6942

aatggctagg aatgtttgac tcccttaatc tcttccccag ctacagagga atcttttctc     7002

tgcctggtct cagaatggga ctgccaactg gctcattggt gggagacaca gtatcctcaa     7062

acctgtggcc actggcatga cagtggtgct ctgtctccct gggtgacacc caccctaggc     7122

ttcctcctgg atgtgatggg gattgccaga gaggctctta gcataaaagg cattaggtgg     7182

gcatttttct gtgtgccccc aaaaagctcc atggaaacag gcacctggta gctgcggaac     7242

acccgtggac ttgtgtatat ggtcataggc tttgggaaga caggacgtaa aggaaaatga     7302

gagaaacaaa atgggtcaga tagctttggc cacagcccca ggcagccttt ggggcctatg     7362

acacttagtg cccttagatg ggatacatct tgcctcggcc ccaagactcc tccaacttac     7422

ccgtcccatc cagggcctgc acagcttaga gaggctcaca gcttggcaaa tgctagggct     7482

tcatcagacc actgacttga ctcagtgttt gttaaaatgg aaccactccc gttggcctac     7542

tgtttctctc ctgtacttct tgtaatgata gttatttatt gactctggta gcaggcagtt     7602

cttaaataaa gatggtttct caacctgttg gggaaaaaaa aaaaaaaa                  7650


<210>  734
<211>  1040
<212>  PRT
<213>  Homo sapiens

<400>  734

Met Gly Thr Ala Thr Arg Arg Lys Pro His Leu Leu Leu Val Ala Ala 
1               5                   10                  15      


Val Ala Leu Val Ser Ser Ser Ala Trp Ser Ser Ala Leu Gly Ser Gln 
            20                  25                  30          


Thr Thr Phe Gly Pro Val Phe Glu Asp Gln Pro Leu Ser Val Leu Phe 
        35                  40                  45              


Pro Glu Glu Ser Thr Glu Glu Gln Val Leu Leu Ala Cys Arg Ala Arg 
    50                  55                  60                  


Ala Ser Pro Pro Ala Thr Tyr Arg Trp Lys Met Asn Gly Thr Glu Met 
65                  70                  75                  80  


Lys Leu Glu Pro Gly Ser Arg His Gln Leu Val Gly Gly Asn Leu Val 
                85                  90                  95      


Ile Met Asn Pro Thr Lys Ala Gln Asp Ala Gly Val Tyr Gln Cys Leu 
            100                 105                 110         


Ala Ser Asn Pro Val Gly Thr Val Val Ser Arg Glu Ala Ile Leu Arg 
        115                 120                 125             


Phe Gly Phe Leu Gln Glu Phe Ser Lys Glu Glu Arg Asp Pro Val Lys 
    130                 135                 140                 


Ala His Glu Gly Trp Gly Val Met Leu Pro Cys Asn Pro Pro Ala His 
145                 150                 155                 160 


Tyr Pro Gly Leu Ser Tyr Arg Trp Leu Leu Asn Glu Phe Pro Asn Phe 
                165                 170                 175     


Ile Pro Thr Asp Gly Arg His Phe Val Ser Gln Thr Thr Gly Asn Leu 
            180                 185                 190         


Tyr Ile Ala Arg Thr Asn Ala Ser Asp Leu Gly Asn Tyr Ser Cys Leu 
        195                 200                 205             


Ala Thr Ser His Met Asp Phe Ser Thr Lys Ser Val Phe Ser Lys Phe 
    210                 215                 220                 


Ala Gln Leu Asn Leu Ala Ala Glu Asp Thr Arg Leu Phe Ala Pro Ser 
225                 230                 235                 240 


Ile Lys Ala Arg Phe Pro Ala Glu Thr Tyr Ala Leu Val Gly Gln Gln 
                245                 250                 255     


Val Thr Leu Glu Cys Phe Ala Phe Gly Asn Pro Val Pro Arg Ile Lys 
            260                 265                 270         


Trp Arg Lys Val Asp Gly Ser Leu Ser Pro Gln Trp Thr Thr Ala Glu 
        275                 280                 285             


Pro Thr Leu Gln Ile Pro Ser Val Ser Phe Glu Asp Glu Gly Thr Tyr 
    290                 295                 300                 


Glu Cys Glu Ala Glu Asn Ser Lys Gly Arg Asp Thr Val Gln Gly Arg 
305                 310                 315                 320 


Ile Ile Val Gln Ala Gln Pro Glu Trp Leu Lys Val Ile Ser Asp Thr 
                325                 330                 335     


Glu Ala Asp Ile Gly Ser Asn Leu Arg Trp Gly Cys Ala Ala Ala Gly 
            340                 345                 350         


Lys Pro Arg Pro Thr Val Arg Trp Leu Arg Asn Gly Glu Pro Leu Ala 
        355                 360                 365             


Ser Gln Asn Arg Val Glu Val Leu Ala Gly Asp Leu Arg Phe Ser Lys 
    370                 375                 380                 


Leu Ser Leu Glu Asp Ser Gly Met Tyr Gln Cys Val Ala Glu Asn Lys 
385                 390                 395                 400 


His Gly Thr Ile Tyr Ala Ser Ala Glu Leu Ala Val Gln Ala Leu Ala 
                405                 410                 415     


Pro Asp Phe Arg Leu Asn Pro Val Arg Arg Leu Ile Pro Ala Ala Arg 
            420                 425                 430         


Gly Gly Glu Ile Leu Ile Pro Cys Gln Pro Arg Ala Ala Pro Lys Ala 
        435                 440                 445             


Val Val Leu Trp Ser Lys Gly Thr Glu Ile Leu Val Asn Ser Ser Arg 
    450                 455                 460                 


Val Thr Val Thr Pro Asp Gly Thr Leu Ile Ile Arg Asn Ile Ser Arg 
465                 470                 475                 480 


Ser Asp Glu Gly Lys Tyr Thr Cys Phe Ala Glu Asn Phe Met Gly Lys 
                485                 490                 495     


Ala Asn Ser Thr Gly Ile Leu Ser Val Arg Asp Ala Thr Lys Ile Thr 
            500                 505                 510         


Leu Ala Pro Ser Ser Ala Asp Ile Asn Leu Gly Asp Asn Leu Thr Leu 
        515                 520                 525             


Gln Cys His Ala Ser His Asp Pro Thr Met Asp Leu Thr Phe Thr Trp 
    530                 535                 540                 


Thr Leu Asp Asp Phe Pro Ile Asp Phe Asp Lys Pro Gly Gly His Tyr 
545                 550                 555                 560 


Arg Arg Thr Asn Val Lys Glu Thr Ile Gly Asp Leu Thr Ile Leu Asn 
                565                 570                 575     


Ala Gln Leu Arg His Gly Gly Lys Tyr Thr Cys Met Ala Gln Thr Val 
            580                 585                 590         


Val Asp Ser Ala Ser Lys Glu Ala Thr Val Leu Val Arg Gly Pro Pro 
        595                 600                 605             


Gly Pro Pro Gly Gly Val Val Val Arg Asp Ile Gly Asp Thr Thr Ile 
    610                 615                 620                 


Gln Leu Ser Trp Ser Arg Gly Phe Asp Asn His Ser Pro Ile Ala Lys 
625                 630                 635                 640 


Tyr Thr Leu Gln Ala Arg Thr Pro Pro Ala Gly Lys Trp Lys Gln Val 
                645                 650                 655     


Arg Thr Asn Pro Ala Asn Ile Glu Gly Asn Ala Glu Thr Ala Gln Val 
            660                 665                 670         


Leu Gly Leu Thr Pro Trp Met Asp Tyr Glu Phe Arg Val Ile Ala Ser 
        675                 680                 685             


Asn Ile Leu Gly Thr Gly Glu Pro Ser Gly Pro Ser Ser Lys Ile Arg 
    690                 695                 700                 


Thr Arg Glu Ala Ala Pro Ser Val Ala Pro Ser Gly Leu Ser Gly Gly 
705                 710                 715                 720 


Gly Gly Ala Pro Gly Glu Leu Ile Val Asn Trp Thr Pro Met Ser Arg 
                725                 730                 735     


Glu Tyr Gln Asn Gly Asp Gly Phe Gly Tyr Leu Leu Ser Phe Arg Arg 
            740                 745                 750         


Gln Gly Ser Thr His Trp Gln Thr Ala Arg Val Pro Gly Ala Asp Ala 
        755                 760                 765             


Gln Tyr Phe Val Tyr Ser Asn Glu Ser Val Arg Pro Tyr Thr Pro Phe 
    770                 775                 780                 


Glu Val Lys Ile Arg Ser Tyr Asn Arg Arg Gly Asp Gly Pro Glu Ser 
785                 790                 795                 800 


Leu Thr Ala Leu Val Tyr Ser Ala Glu Glu Glu Pro Arg Val Ala Pro 
                805                 810                 815     


Thr Lys Val Trp Ala Lys Gly Val Ser Ser Ser Glu Met Asn Val Thr 
            820                 825                 830         


Trp Glu Pro Val Gln Gln Asp Met Asn Gly Ile Leu Leu Gly Tyr Glu 
        835                 840                 845             


Ile Arg Tyr Trp Lys Ala Gly Asp Lys Glu Ala Ala Ala Asp Arg Val 
    850                 855                 860                 


Arg Thr Ala Gly Leu Asp Thr Ser Ala Arg Val Ser Gly Leu His Pro 
865                 870                 875                 880 


Asn Thr Lys Tyr His Val Thr Val Arg Ala Tyr Asn Arg Ala Gly Thr 
                885                 890                 895     


Gly Pro Ala Ser Pro Ser Ala Asn Ala Thr Thr Met Lys Pro Pro Pro 
            900                 905                 910         


Arg Arg Pro Pro Gly Asn Ile Ser Trp Thr Phe Ser Ser Ser Ser Leu 
        915                 920                 925             


Ser Ile Lys Trp Asp Pro Val Val Pro Phe Arg Asn Glu Ser Ala Val 
    930                 935                 940                 


Thr Gly Tyr Lys Met Leu Tyr Gln Asn Asp Leu His Leu Thr Pro Thr 
945                 950                 955                 960 


Leu His Leu Thr Gly Lys Asn Trp Ile Glu Ile Pro Val Pro Glu Asp 
                965                 970                 975     


Ile Gly His Ala Leu Val Gln Ile Arg Thr Thr Gly Pro Gly Gly Asp 
            980                 985                 990         


Gly Ile Pro Ala Glu Val His Ile  Val Arg Asn Gly Gly  Thr Ser Met 
        995                 1000                 1005             


Met Val  Glu Asn Met Ala Val  Arg Pro Ala Pro His  Pro Gly Thr 
    1010                 1015                 1020             


Val Ile  Ser His Ser Val Ala  Met Leu Ile Leu Ile  Gly Ser Leu 
    1025                 1030                 1035             


Glu Leu  
    1040 


<210>  735
<211>  1682
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (154)..(1440)

<400>  735
ggaatggctg aaaaagccca cacctggaaa tcactccctc cctgctcctc cacggcaggt       60

tgcatctgcg agacgcttcg gtcattagag gaatgagccg ggagtgagca attcaccagc      120

tctccagcac ttggtggaaa gcagcaggca agg atg gat gtg gtt gac agc ctt       174
                                     Met Asp Val Val Asp Ser Leu          
                                     1               5                    

ctt gtg aat gga agc aac atc act cct ccc tgt gaa ctc ggg ctc gaa        222
Leu Val Asn Gly Ser Asn Ile Thr Pro Pro Cys Glu Leu Gly Leu Glu           
        10                  15                  20                        

aat gag acg ctt ttc tgc ttg gat cag ccc cgt cct tcc aaa gag tgg        270
Asn Glu Thr Leu Phe Cys Leu Asp Gln Pro Arg Pro Ser Lys Glu Trp           
    25                  30                  35                            

cag cca gcg gtg cag att ctc ttg tac tcc ttg ata ttc ctg ctc agc        318
Gln Pro Ala Val Gln Ile Leu Leu Tyr Ser Leu Ile Phe Leu Leu Ser           
40                  45                  50                  55            

gtg ctg gga aac acg ctg gtc atc acc gtg ctg att cgg aac aag cgg        366
Val Leu Gly Asn Thr Leu Val Ile Thr Val Leu Ile Arg Asn Lys Arg           
                60                  65                  70                

atg cgg acg gtc acc aac atc ttc ctc ctc tcc ctg gct gtc agc gac        414
Met Arg Thr Val Thr Asn Ile Phe Leu Leu Ser Leu Ala Val Ser Asp           
            75                  80                  85                    

ctc atg ctc tgt ctc ttc tgc atg ccg ttc aac ctc atc ccc aat ctg        462
Leu Met Leu Cys Leu Phe Cys Met Pro Phe Asn Leu Ile Pro Asn Leu           
        90                  95                  100                       

ctc aag gat ttc atc ttc ggg agc gcc gtt tgc aag acc acc acc tac        510
Leu Lys Asp Phe Ile Phe Gly Ser Ala Val Cys Lys Thr Thr Thr Tyr           
    105                 110                 115                           

ttc atg ggc acc tct gtg agt gta tct acc ttt aat ctg gta gcc ata        558
Phe Met Gly Thr Ser Val Ser Val Ser Thr Phe Asn Leu Val Ala Ile           
120                 125                 130                 135           

tct cta gag aga tat ggt gcg att tgc aaa ccc tta cag tcc cgg gtc        606
Ser Leu Glu Arg Tyr Gly Ala Ile Cys Lys Pro Leu Gln Ser Arg Val           
                140                 145                 150               

tgg cag aca aaa tcc cat gct ttg aag gtg att gct gct acc tgg tgc        654
Trp Gln Thr Lys Ser His Ala Leu Lys Val Ile Ala Ala Thr Trp Cys           
            155                 160                 165                   

ctt tcc ttt acc atc atg act ccg tac ccc att tat agc aac ttg gtg        702
Leu Ser Phe Thr Ile Met Thr Pro Tyr Pro Ile Tyr Ser Asn Leu Val           
        170                 175                 180                       

cct ttt acc aaa aat aac aac cag acc gcg aat atg tgc cgc ttt cta        750
Pro Phe Thr Lys Asn Asn Asn Gln Thr Ala Asn Met Cys Arg Phe Leu           
    185                 190                 195                           

ctg cca aat gat gtt atg cag cag tcc tgg cac aca ttc ctg tta ctc        798
Leu Pro Asn Asp Val Met Gln Gln Ser Trp His Thr Phe Leu Leu Leu           
200                 205                 210                 215           

atc ctc ttt ctt att cct gga att gtg atg atg gtg gca tat gga tta        846
Ile Leu Phe Leu Ile Pro Gly Ile Val Met Met Val Ala Tyr Gly Leu           
                220                 225                 230               

atc tct ttg gaa ctc tac cag gga ata aaa ttt gag gct agc cag aag        894
Ile Ser Leu Glu Leu Tyr Gln Gly Ile Lys Phe Glu Ala Ser Gln Lys           
            235                 240                 245                   

aag tct gct aaa gaa agg aaa cct agc acc acc agc agc ggc aaa tat        942
Lys Ser Ala Lys Glu Arg Lys Pro Ser Thr Thr Ser Ser Gly Lys Tyr           
        250                 255                 260                       

gag gac agc gat ggg tgt tac ctg caa aag acc agg ccc ccg agg aag        990
Glu Asp Ser Asp Gly Cys Tyr Leu Gln Lys Thr Arg Pro Pro Arg Lys           
    265                 270                 275                           

ctg gag ctc cgg cag ctg tcc acc ggc agc agc agc agg gcc aac cgc       1038
Leu Glu Leu Arg Gln Leu Ser Thr Gly Ser Ser Ser Arg Ala Asn Arg           
280                 285                 290                 295           

atc cgg agt aac agc tcc gca gcc aac ctg atg gcc aag aaa agg gtg       1086
Ile Arg Ser Asn Ser Ser Ala Ala Asn Leu Met Ala Lys Lys Arg Val           
                300                 305                 310               

atc cgc atg ctc atc gtc atc gtg gtc ctc ttc ttc ctg tgc tgg atg       1134
Ile Arg Met Leu Ile Val Ile Val Val Leu Phe Phe Leu Cys Trp Met           
            315                 320                 325                   

ccc atc ttc agc gcc aac gcc tgg cgg gcc tac gac acc gcc tcc gca       1182
Pro Ile Phe Ser Ala Asn Ala Trp Arg Ala Tyr Asp Thr Ala Ser Ala           
        330                 335                 340                       

gag cgc cgc ctc tca gga acc ccc att tcc ttc atc ctc ctc ctg tcc       1230
Glu Arg Arg Leu Ser Gly Thr Pro Ile Ser Phe Ile Leu Leu Leu Ser           
    345                 350                 355                           

tac acc tcc tcc tgc gtc aac ccc atc atc tac tgc ttc atg aac aaa       1278
Tyr Thr Ser Ser Cys Val Asn Pro Ile Ile Tyr Cys Phe Met Asn Lys           
360                 365                 370                 375           

cgc ttc cgc ctc ggc ttc atg gcc acc ttc ccc tgc tgc ccc aat cct       1326
Arg Phe Arg Leu Gly Phe Met Ala Thr Phe Pro Cys Cys Pro Asn Pro           
                380                 385                 390               

ggt ccc cca ggg gcg agg gga gag gtg ggg gag gag gag gaa ggc ggg       1374
Gly Pro Pro Gly Ala Arg Gly Glu Val Gly Glu Glu Glu Glu Gly Gly           
            395                 400                 405                   

acc aca gga gcc tct ctg tcc agg ttc tcg tac agc cat atg agt gcc       1422
Thr Thr Gly Ala Ser Leu Ser Arg Phe Ser Tyr Ser His Met Ser Ala           
        410                 415                 420                       

tcg gtg cca ccc cag tga gatgtcccct gaccctccac cgcagaagga              1470
Ser Val Pro Pro Gln                                                       
    425                                                                   

aggcagggag gaggcagaga agaaagaacg gaagaagaga tcaggaagag aaggagcaga     1530

gctgatggag aaggaaggct ccatctccag tgggaactct tcaaggtctg cttttcatcc     1590

ttcatctgga ttccagagca ctgctccagt ggggccatga ttggtttcta ggcagttcaa     1650

agcaggatat gttaagtaac actcaccatc ag                                   1682


<210>  736
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  736

Met Asp Val Val Asp Ser Leu Leu Val Asn Gly Ser Asn Ile Thr Pro 
1               5                   10                  15      


Pro Cys Glu Leu Gly Leu Glu Asn Glu Thr Leu Phe Cys Leu Asp Gln 
            20                  25                  30          


Pro Arg Pro Ser Lys Glu Trp Gln Pro Ala Val Gln Ile Leu Leu Tyr 
        35                  40                  45              


Ser Leu Ile Phe Leu Leu Ser Val Leu Gly Asn Thr Leu Val Ile Thr 
    50                  55                  60                  


Val Leu Ile Arg Asn Lys Arg Met Arg Thr Val Thr Asn Ile Phe Leu 
65                  70                  75                  80  


Leu Ser Leu Ala Val Ser Asp Leu Met Leu Cys Leu Phe Cys Met Pro 
                85                  90                  95      


Phe Asn Leu Ile Pro Asn Leu Leu Lys Asp Phe Ile Phe Gly Ser Ala 
            100                 105                 110         


Val Cys Lys Thr Thr Thr Tyr Phe Met Gly Thr Ser Val Ser Val Ser 
        115                 120                 125             


Thr Phe Asn Leu Val Ala Ile Ser Leu Glu Arg Tyr Gly Ala Ile Cys 
    130                 135                 140                 


Lys Pro Leu Gln Ser Arg Val Trp Gln Thr Lys Ser His Ala Leu Lys 
145                 150                 155                 160 


Val Ile Ala Ala Thr Trp Cys Leu Ser Phe Thr Ile Met Thr Pro Tyr 
                165                 170                 175     


Pro Ile Tyr Ser Asn Leu Val Pro Phe Thr Lys Asn Asn Asn Gln Thr 
            180                 185                 190         


Ala Asn Met Cys Arg Phe Leu Leu Pro Asn Asp Val Met Gln Gln Ser 
        195                 200                 205             


Trp His Thr Phe Leu Leu Leu Ile Leu Phe Leu Ile Pro Gly Ile Val 
    210                 215                 220                 


Met Met Val Ala Tyr Gly Leu Ile Ser Leu Glu Leu Tyr Gln Gly Ile 
225                 230                 235                 240 


Lys Phe Glu Ala Ser Gln Lys Lys Ser Ala Lys Glu Arg Lys Pro Ser 
                245                 250                 255     


Thr Thr Ser Ser Gly Lys Tyr Glu Asp Ser Asp Gly Cys Tyr Leu Gln 
            260                 265                 270         


Lys Thr Arg Pro Pro Arg Lys Leu Glu Leu Arg Gln Leu Ser Thr Gly 
        275                 280                 285             


Ser Ser Ser Arg Ala Asn Arg Ile Arg Ser Asn Ser Ser Ala Ala Asn 
    290                 295                 300                 


Leu Met Ala Lys Lys Arg Val Ile Arg Met Leu Ile Val Ile Val Val 
305                 310                 315                 320 


Leu Phe Phe Leu Cys Trp Met Pro Ile Phe Ser Ala Asn Ala Trp Arg 
                325                 330                 335     


Ala Tyr Asp Thr Ala Ser Ala Glu Arg Arg Leu Ser Gly Thr Pro Ile 
            340                 345                 350         


Ser Phe Ile Leu Leu Leu Ser Tyr Thr Ser Ser Cys Val Asn Pro Ile 
        355                 360                 365             


Ile Tyr Cys Phe Met Asn Lys Arg Phe Arg Leu Gly Phe Met Ala Thr 
    370                 375                 380                 


Phe Pro Cys Cys Pro Asn Pro Gly Pro Pro Gly Ala Arg Gly Glu Val 
385                 390                 395                 400 


Gly Glu Glu Glu Glu Gly Gly Thr Thr Gly Ala Ser Leu Ser Arg Phe 
                405                 410                 415     


Ser Tyr Ser His Met Ser Ala Ser Val Pro Pro Gln 
            420                 425             


<210>  737
<211>  3809
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (311)..(3055)

<400>  737
tctgcccctt ccccccgccc ccgcccgcct cggctcccgc agcgctagtg tgtccgccta       60

gttcagtgtg cgtggagatt aggtccaagc gcccgcccag aggcaggcag tccgcgagcc      120

cagccgccgc tgtcgccgcc agtagcagcc ttcgccagca gcgccgcggc ggaaccgggc      180

gcaggggagc gagcccggcc ccgccagccc agcccagccc agccctactc cctccccacg      240

ccagggcagc agccgttgct cagagagaag gtggaggaag aaatccagac cctagcacgc      300

gcgcaccatc atg gac cat tat gat tct cag caa acc aac gat tac atg         349
           Met Asp His Tyr Asp Ser Gln Gln Thr Asn Asp Tyr Met            
           1               5                   10                         

cag cca gaa gag gac tgg gac cgg gac ctg ctc ctg gac ccg gcc tgg        397
Gln Pro Glu Glu Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp           
    15                  20                  25                            

gag aag cag cag aga aag aca ttc acg gca tgg tgt aac tcc cac ctc        445
Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu           
30                  35                  40                  45            

cgg aag gcg ggg aca cag atc gag aac atc gaa gag gac ttc cgg gat        493
Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Glu Glu Asp Phe Arg Asp           
                50                  55                  60                

ggc ctg aag ctc atg ctg ctg ctg gag gtc atc tca ggt gaa cgc ttg        541
Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu           
            65                  70                  75                    

gcc aag cca gag cga ggc aag atg aga gtg cac aag atc tcc aac gtc        589
Ala Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Ser Asn Val           
        80                  85                  90                        

aac aag gcc ctg gat ttc ata gcc agc aaa ggc gtc aaa ctg gtg tcc        637
Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser           
    95                  100                 105                           

atc gga gcc gaa gaa atc gtg gat ggg aat gtg aag atg acc ctg ggc        685
Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Val Lys Met Thr Leu Gly           
110                 115                 120                 125           

atg atc tgg acc atc atc ctg cgc ttt gcc atc cag gac atc tcc gtg        733
Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val           
                130                 135                 140               

gaa gag act tca gcc aag gaa ggg ctg ctc ctg tgg tgt cag aga aag        781
Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys           
            145                 150                 155                   

aca gcc cct tac aaa aat gtc aac atc cag aac ttc cac ata agc tgg        829
Thr Ala Pro Tyr Lys Asn Val Asn Ile Gln Asn Phe His Ile Ser Trp           
        160                 165                 170                       

aag gat ggc ctc ggc ttc tgt gct ttg atc cac cga cac cgg ccc gag        877
Lys Asp Gly Leu Gly Phe Cys Ala Leu Ile His Arg His Arg Pro Glu           
    175                 180                 185                           

ctg att gac tac ggg aag ctg cgg aag gat gat cca ctc aca aat ctg        925
Leu Ile Asp Tyr Gly Lys Leu Arg Lys Asp Asp Pro Leu Thr Asn Leu           
190                 195                 200                 205           

aat acg gct ttt gac gtg gca gag aag tac ctg gac atc ccc aag atg        973
Asn Thr Ala Phe Asp Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met           
                210                 215                 220               

ctg gat gcc gaa gac atc gtt gga act gcc cga ccg gat gag aaa gcc       1021
Leu Asp Ala Glu Asp Ile Val Gly Thr Ala Arg Pro Asp Glu Lys Ala           
            225                 230                 235                   

atc atg act tac gtg tct agc ttc tac cac gcc ttc tct gga gcc cag       1069
Ile Met Thr Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln           
        240                 245                 250                       

aag gcg gag aca gca gcc aat cgc atc tgc aag gtg ttg gcc gtc aac       1117
Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn           
    255                 260                 265                           

cag gag aac gag cag ctt atg gaa gac tac gag aag ctg gcc agt gat       1165
Gln Glu Asn Glu Gln Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp           
270                 275                 280                 285           

ctg ttg gag tgg atc cgc cgc aca atc ccg tgg ctg gag aac cgg gtg       1213
Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asn Arg Val           
                290                 295                 300               

ccc gag aac acc atg cat gcc atg caa cag aag ctg gag gac ttc cgg       1261
Pro Glu Asn Thr Met His Ala Met Gln Gln Lys Leu Glu Asp Phe Arg           
            305                 310                 315                   

gac tac cgg cgc ctg cac aag ccg ccc aag gtg cag gag aag tgc cag       1309
Asp Tyr Arg Arg Leu His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln           
        320                 325                 330                       

ctg gag atc aac ttc aac acg ctg cag acc aag ctg cgg ctc agc aac       1357
Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn           
    335                 340                 345                           

cgg cct gcc ttc atg ccc tct gag ggc agg atg gtc tcg gac atc aac       1405
Arg Pro Ala Phe Met Pro Ser Glu Gly Arg Met Val Ser Asp Ile Asn           
350                 355                 360                 365           

aat gcc tgg ggc tgc ctg gag cag gtg gag aag ggc tat gag gag tgg       1453
Asn Ala Trp Gly Cys Leu Glu Gln Val Glu Lys Gly Tyr Glu Glu Trp           
                370                 375                 380               

ttg ctg aat gag atc cgg agg ctg gag cga ctg gac cac ctg gca gag       1501
Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu           
            385                 390                 395                   

aag ttc cgg cag aag gcc tcc atc cac gag gcc tgg act gac ggc aaa       1549
Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys           
        400                 405                 410                       

gag gcc atg ctg cga cag aag gac tat gag acc gcc acc ctc tcg gag       1597
Glu Ala Met Leu Arg Gln Lys Asp Tyr Glu Thr Ala Thr Leu Ser Glu           
    415                 420                 425                           

atc aag gcc ctg ctc aag aag cat gag gcc ttc gag agt gac ctg gct       1645
Ile Lys Ala Leu Leu Lys Lys His Glu Ala Phe Glu Ser Asp Leu Ala           
430                 435                 440                 445           

gcc cac cag gac cgt gtg gag cag att gcc gcc atc gca cag gag ctc       1693
Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu           
                450                 455                 460               

aat gag ctg gac tat tat gac tca ccc agt gtc aac gcc cgt tgc caa       1741
Asn Glu Leu Asp Tyr Tyr Asp Ser Pro Ser Val Asn Ala Arg Cys Gln           
            465                 470                 475                   

aag atc tgt gac cag tgg gac aat ctg ggg gcc cta act cag aag cga       1789
Lys Ile Cys Asp Gln Trp Asp Asn Leu Gly Ala Leu Thr Gln Lys Arg           
        480                 485                 490                       

agg gaa gct ctg gag cgg acc gag aaa ctg ctg gag acc att gac cag       1837
Arg Glu Ala Leu Glu Arg Thr Glu Lys Leu Leu Glu Thr Ile Asp Gln           
    495                 500                 505                           

ctg tac ttg gag tat gcc aag cgg gct gca ccc ttc aac aac tgg atg       1885
Leu Tyr Leu Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met           
510                 515                 520                 525           

gag ggg gcc atg gag gac ctg cag gac acc ttc att gtg cac acc att       1933
Glu Gly Ala Met Glu Asp Leu Gln Asp Thr Phe Ile Val His Thr Ile           
                530                 535                 540               

gag gag atc cag gga ctg acc aca gcc cat gag cag ttc aag gcc acc       1981
Glu Glu Ile Gln Gly Leu Thr Thr Ala His Glu Gln Phe Lys Ala Thr           
            545                 550                 555                   

ctc cct gat gcc gac aag gag cgc ctg gcc atc ctg ggc atc cac aat       2029
Leu Pro Asp Ala Asp Lys Glu Arg Leu Ala Ile Leu Gly Ile His Asn           
        560                 565                 570                       

gag gtg tcc aag att gtc cag acc tac cac gtc aat atg gcg ggc acc       2077
Glu Val Ser Lys Ile Val Gln Thr Tyr His Val Asn Met Ala Gly Thr           
    575                 580                 585                           

aac ccc tac aca acc atc acg cct cag gag atc aat ggc aaa tgg gac       2125
Asn Pro Tyr Thr Thr Ile Thr Pro Gln Glu Ile Asn Gly Lys Trp Asp           
590                 595                 600                 605           

cac gtg cgg cag ctg gtg cct cgg agg gac caa gct ctg acg gag gag       2173
His Val Arg Gln Leu Val Pro Arg Arg Asp Gln Ala Leu Thr Glu Glu           
                610                 615                 620               

cat gcc cga cag cag cac aat gag agg cta cgc aag cag ttt gga gcc       2221
His Ala Arg Gln Gln His Asn Glu Arg Leu Arg Lys Gln Phe Gly Ala           
            625                 630                 635                   

cag gcc aat gtc atc ggg ccc tgg atc cag acc aag atg gag gag atc       2269
Gln Ala Asn Val Ile Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile           
        640                 645                 650                       

ggg agg atc tcc att gag atg cat ggg acc ctg gag gac cag ctc agc       2317
Gly Arg Ile Ser Ile Glu Met His Gly Thr Leu Glu Asp Gln Leu Ser           
    655                 660                 665                           

cac ctg cgg cag tat gag aag agc atc gtc aac tac aag cca aag att       2365
His Leu Arg Gln Tyr Glu Lys Ser Ile Val Asn Tyr Lys Pro Lys Ile           
670                 675                 680                 685           

gat cag ctg gag ggc gac cac cag ctc atc cag gag gcg ctc atc ttc       2413
Asp Gln Leu Glu Gly Asp His Gln Leu Ile Gln Glu Ala Leu Ile Phe           
                690                 695                 700               

gac aac aag cac acc aac tac acc atg gag cac atc cgt gtg ggc tgg       2461
Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp           
            705                 710                 715                   

gag cag ctg ctc acc acc atc gcc agg acc atc aat gag gta gag aac       2509
Glu Gln Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn           
        720                 725                 730                       

cag atc ctg acc cgg gat gcc aag ggc atc agc cag gag cag atg aat       2557
Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Asn           
    735                 740                 745                           

gag ttc cgg gcc tcc ttc aac cac ttt gac cgg gat cac tcc ggc aca       2605
Glu Phe Arg Ala Ser Phe Asn His Phe Asp Arg Asp His Ser Gly Thr           
750                 755                 760                 765           

ctg ggt ccc gag gag ttc aaa gcc tgc ctc atc agc ttg ggt tat gat       2653
Leu Gly Pro Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp           
                770                 775                 780               

att ggc aac gac ccc cag aag aag aca ggc atg atg gac acg gat gat       2701
Ile Gly Asn Asp Pro Gln Lys Lys Thr Gly Met Met Asp Thr Asp Asp           
            785                 790                 795                   

ttc cgc gcc tgc ctg atc tcc atg ggt tac aac atg gga gaa gca gaa       2749
Phe Arg Ala Cys Leu Ile Ser Met Gly Tyr Asn Met Gly Glu Ala Glu           
        800                 805                 810                       

ttt gcc cgc atc atg agc att gtg gac ccc aac cgc ctg ggg gta gtg       2797
Phe Ala Arg Ile Met Ser Ile Val Asp Pro Asn Arg Leu Gly Val Val           
    815                 820                 825                           

aca ttc cag gcc ttc att gac ttc atg tcc cgc gag aca gcc gac aca       2845
Thr Phe Gln Ala Phe Ile Asp Phe Met Ser Arg Glu Thr Ala Asp Thr           
830                 835                 840                 845           

gat aca gca gac caa gtc atg gct tcc ttc aag atc ctg gct ggg gac       2893
Asp Thr Ala Asp Gln Val Met Ala Ser Phe Lys Ile Leu Ala Gly Asp           
                850                 855                 860               

aag aac tac att acc atg gac gag ctg cgc cgc gag ctg cca ccc gac       2941
Lys Asn Tyr Ile Thr Met Asp Glu Leu Arg Arg Glu Leu Pro Pro Asp           
            865                 870                 875                   

cag gct gag tac tgc atc gcg cgg atg gcc ccc tac acc ggc ccc gac       2989
Gln Ala Glu Tyr Cys Ile Ala Arg Met Ala Pro Tyr Thr Gly Pro Asp           
        880                 885                 890                       

tcc gtg cca ggt gct ctg gac tac atg tcc ttc tcc acg gcg ctg tac       3037
Ser Val Pro Gly Ala Leu Asp Tyr Met Ser Phe Ser Thr Ala Leu Tyr           
    895                 900                 905                           

ggc gag agt gac ctc taa tccaccccgc ccggccgccc tcgtcttgtg              3085
Gly Glu Ser Asp Leu                                                       
910                                                                       

cgccgtgccc tgccttgcac ctccgccgtc gcccatctcc tgcctgggtt cggtttcagc     3145

tcccagcctc cacccgggtg agctggggcc cacgtggcat cgatcctccc tgcccgcgaa     3205

gtgacagttt acaaaattat tttctgcaaa aaagaaaaaa aagttacgtt aaaaaccaaa     3265

aaactacata ttttattata gaaaaagtat tttttctcca ccagacaaat ggaaaaaaag     3325

aggaaagatt aactatttgc accgaaatgt cttgttttgt tgcgacatag gaaaataacc     3385

aagcacaaag ttatattcca tcctttttac tgattttttt ttcttctatc tgttccatct     3445

gctgtattca tttctccaat ctcatgtcca ttttggtgtg ggagtcgggg tagggggtac     3505

tcttgtcaaa aggcacattg gtgcatgtgt gtttgctagc tcacttgtcc atgaaaatat     3565

tttatgatat taaagaaaat cttttgaaat ggctgttttt taaggaagag aatttatgtg     3625

gcttctcatt tttaaatccc ctcagaggtg tgactagtct ctttatcagc acacacttaa     3685

aaaattttta atattgtcta ttaaaaatag gacaaacttg gagagtatgg acaactttga     3745

tattgcttgg cacagatggt attaaaaaaa ccacactcct atgacaaaaa aaaaaaaaaa     3805

aaaa                                                                  3809


<210>  738
<211>  914
<212>  PRT
<213>  Homo sapiens

<400>  738

Met Asp His Tyr Asp Ser Gln Gln Thr Asn Asp Tyr Met Gln Pro Glu 
1               5                   10                  15      


Glu Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp Glu Lys Gln 
            20                  25                  30          


Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu Arg Lys Ala 
        35                  40                  45              


Gly Thr Gln Ile Glu Asn Ile Glu Glu Asp Phe Arg Asp Gly Leu Lys 
    50                  55                  60                  


Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu Ala Lys Pro 
65                  70                  75                  80  


Glu Arg Gly Lys Met Arg Val His Lys Ile Ser Asn Val Asn Lys Ala 
                85                  90                  95      


Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser Ile Gly Ala 
            100                 105                 110         


Glu Glu Ile Val Asp Gly Asn Val Lys Met Thr Leu Gly Met Ile Trp 
        115                 120                 125             


Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val Glu Glu Thr 
    130                 135                 140                 


Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys Thr Ala Pro 
145                 150                 155                 160 


Tyr Lys Asn Val Asn Ile Gln Asn Phe His Ile Ser Trp Lys Asp Gly 
                165                 170                 175     


Leu Gly Phe Cys Ala Leu Ile His Arg His Arg Pro Glu Leu Ile Asp 
            180                 185                 190         


Tyr Gly Lys Leu Arg Lys Asp Asp Pro Leu Thr Asn Leu Asn Thr Ala 
        195                 200                 205             


Phe Asp Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met Leu Asp Ala 
    210                 215                 220                 


Glu Asp Ile Val Gly Thr Ala Arg Pro Asp Glu Lys Ala Ile Met Thr 
225                 230                 235                 240 


Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln Lys Ala Glu 
                245                 250                 255     


Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn Gln Glu Asn 
            260                 265                 270         


Glu Gln Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp Leu Leu Glu 
        275                 280                 285             


Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asn Arg Val Pro Glu Asn 
    290                 295                 300                 


Thr Met His Ala Met Gln Gln Lys Leu Glu Asp Phe Arg Asp Tyr Arg 
305                 310                 315                 320 


Arg Leu His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln Leu Glu Ile 
                325                 330                 335     


Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn Arg Pro Ala 
            340                 345                 350         


Phe Met Pro Ser Glu Gly Arg Met Val Ser Asp Ile Asn Asn Ala Trp 
        355                 360                 365             


Gly Cys Leu Glu Gln Val Glu Lys Gly Tyr Glu Glu Trp Leu Leu Asn 
    370                 375                 380                 


Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu Lys Phe Arg 
385                 390                 395                 400 


Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys Glu Ala Met 
                405                 410                 415     


Leu Arg Gln Lys Asp Tyr Glu Thr Ala Thr Leu Ser Glu Ile Lys Ala 
            420                 425                 430         


Leu Leu Lys Lys His Glu Ala Phe Glu Ser Asp Leu Ala Ala His Gln 
        435                 440                 445             


Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu Asn Glu Leu 
    450                 455                 460                 


Asp Tyr Tyr Asp Ser Pro Ser Val Asn Ala Arg Cys Gln Lys Ile Cys 
465                 470                 475                 480 


Asp Gln Trp Asp Asn Leu Gly Ala Leu Thr Gln Lys Arg Arg Glu Ala 
                485                 490                 495     


Leu Glu Arg Thr Glu Lys Leu Leu Glu Thr Ile Asp Gln Leu Tyr Leu 
            500                 505                 510         


Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met Glu Gly Ala 
        515                 520                 525             


Met Glu Asp Leu Gln Asp Thr Phe Ile Val His Thr Ile Glu Glu Ile 
    530                 535                 540                 


Gln Gly Leu Thr Thr Ala His Glu Gln Phe Lys Ala Thr Leu Pro Asp 
545                 550                 555                 560 


Ala Asp Lys Glu Arg Leu Ala Ile Leu Gly Ile His Asn Glu Val Ser 
                565                 570                 575     


Lys Ile Val Gln Thr Tyr His Val Asn Met Ala Gly Thr Asn Pro Tyr 
            580                 585                 590         


Thr Thr Ile Thr Pro Gln Glu Ile Asn Gly Lys Trp Asp His Val Arg 
        595                 600                 605             


Gln Leu Val Pro Arg Arg Asp Gln Ala Leu Thr Glu Glu His Ala Arg 
    610                 615                 620                 


Gln Gln His Asn Glu Arg Leu Arg Lys Gln Phe Gly Ala Gln Ala Asn 
625                 630                 635                 640 


Val Ile Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile Gly Arg Ile 
                645                 650                 655     


Ser Ile Glu Met His Gly Thr Leu Glu Asp Gln Leu Ser His Leu Arg 
            660                 665                 670         


Gln Tyr Glu Lys Ser Ile Val Asn Tyr Lys Pro Lys Ile Asp Gln Leu 
        675                 680                 685             


Glu Gly Asp His Gln Leu Ile Gln Glu Ala Leu Ile Phe Asp Asn Lys 
    690                 695                 700                 


His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp Glu Gln Leu 
705                 710                 715                 720 


Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn Gln Ile Leu 
                725                 730                 735     


Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Asn Glu Phe Arg 
            740                 745                 750         


Ala Ser Phe Asn His Phe Asp Arg Asp His Ser Gly Thr Leu Gly Pro 
        755                 760                 765             


Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp Ile Gly Asn 
    770                 775                 780                 


Asp Pro Gln Lys Lys Thr Gly Met Met Asp Thr Asp Asp Phe Arg Ala 
785                 790                 795                 800 


Cys Leu Ile Ser Met Gly Tyr Asn Met Gly Glu Ala Glu Phe Ala Arg 
                805                 810                 815     


Ile Met Ser Ile Val Asp Pro Asn Arg Leu Gly Val Val Thr Phe Gln 
            820                 825                 830         


Ala Phe Ile Asp Phe Met Ser Arg Glu Thr Ala Asp Thr Asp Thr Ala 
        835                 840                 845             


Asp Gln Val Met Ala Ser Phe Lys Ile Leu Ala Gly Asp Lys Asn Tyr 
    850                 855                 860                 


Ile Thr Met Asp Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu 
865                 870                 875                 880 


Tyr Cys Ile Ala Arg Met Ala Pro Tyr Thr Gly Pro Asp Ser Val Pro 
                885                 890                 895     


Gly Ala Leu Asp Tyr Met Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser 
            900                 905                 910         


Asp Leu 
        


<210>  739
<211>  1763
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (142)..(1503)

<400>  739
cttctggtaa ggaggccccg tgatcagctc cagccatttg cagtcctggc tatcccagga       60

gcttacataa agggacaatt ggagcctgag aggtgacagt gctgacacta caaggctcgg      120

agctccgggc actcagacat c atg agt tgg tcc ttg cac ccc cgg aat tta        171
                        Met Ser Trp Ser Leu His Pro Arg Asn Leu           
                        1               5                   10            

att ctc tac ttc tat gct ctt tta ttt ctc tct tca aca tgt gta gca        219
Ile Leu Tyr Phe Tyr Ala Leu Leu Phe Leu Ser Ser Thr Cys Val Ala           
                15                  20                  25                

tat gtt gct acc aga gac aac tgc tgc atc tta gat gaa aga ttc ggt        267
Tyr Val Ala Thr Arg Asp Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly           
            30                  35                  40                    

agt tat tgt cca act acc tgt ggc att gca gat ttc ctg tct act tat        315
Ser Tyr Cys Pro Thr Thr Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr           
        45                  50                  55                        

caa acc aaa gta gac aag gat cta cag tct ttg gaa gac atc tta cat        363
Gln Thr Lys Val Asp Lys Asp Leu Gln Ser Leu Glu Asp Ile Leu His           
    60                  65                  70                            

caa gtt gaa aac aaa aca tca gaa gtc aaa cag ctg ata aaa gca atc        411
Gln Val Glu Asn Lys Thr Ser Glu Val Lys Gln Leu Ile Lys Ala Ile           
75                  80                  85                  90            

caa ctc act tat aat cct gat gaa tca tca aaa cca aat atg ata gac        459
Gln Leu Thr Tyr Asn Pro Asp Glu Ser Ser Lys Pro Asn Met Ile Asp           
                95                  100                 105               

gct gct act ttg aag tcc agg aaa atg tta gaa gaa att atg aaa tat        507
Ala Ala Thr Leu Lys Ser Arg Lys Met Leu Glu Glu Ile Met Lys Tyr           
            110                 115                 120                   

gaa gca tcg att tta aca cat gac tca agt att cga tat ttg cag gaa        555
Glu Ala Ser Ile Leu Thr His Asp Ser Ser Ile Arg Tyr Leu Gln Glu           
        125                 130                 135                       

ata tat aat tca aat aat caa aag att gtt aac ctg aaa gag aag gta        603
Ile Tyr Asn Ser Asn Asn Gln Lys Ile Val Asn Leu Lys Glu Lys Val           
    140                 145                 150                           

gcc cag ctt gaa gca cag tgc cag gaa cct tgc aaa gac acg gtg caa        651
Ala Gln Leu Glu Ala Gln Cys Gln Glu Pro Cys Lys Asp Thr Val Gln           
155                 160                 165                 170           

atc cat gat atc act ggg aaa gat tgt caa gac att gcc aat aag gga        699
Ile His Asp Ile Thr Gly Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly           
                175                 180                 185               

gct aaa cag agc ggg ctt tac ttt att aaa cct ctg aaa gct aac cag        747
Ala Lys Gln Ser Gly Leu Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln           
            190                 195                 200                   

caa ttc tta gtc tac tgt gaa atc gat ggg tct gga aat gga tgg act        795
Gln Phe Leu Val Tyr Cys Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr           
        205                 210                 215                       

gtg ttt cag aag aga ctt gat ggc agt gta gat ttc aag aaa aac tgg        843
Val Phe Gln Lys Arg Leu Asp Gly Ser Val Asp Phe Lys Lys Asn Trp           
    220                 225                 230                           

att caa tat aaa gaa gga ttt gga cat ctg tct cct act ggc aca aca        891
Ile Gln Tyr Lys Glu Gly Phe Gly His Leu Ser Pro Thr Gly Thr Thr           
235                 240                 245                 250           

gaa ttt tgg ctg gga aat gag aag att cat ttg ata agc aca cag tct        939
Glu Phe Trp Leu Gly Asn Glu Lys Ile His Leu Ile Ser Thr Gln Ser           
                255                 260                 265               

gcc atc cca tat gca tta aga gtg gaa ctg gaa gac tgg aat ggc aga        987
Ala Ile Pro Tyr Ala Leu Arg Val Glu Leu Glu Asp Trp Asn Gly Arg           
            270                 275                 280                   

acc agt act gca gac tat gcc atg ttc aag gtg gga cct gaa gct gac       1035
Thr Ser Thr Ala Asp Tyr Ala Met Phe Lys Val Gly Pro Glu Ala Asp           
        285                 290                 295                       

aag tac cgc cta aca tat gcc tac ttc gct ggt ggg gat gct gga gat       1083
Lys Tyr Arg Leu Thr Tyr Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp           
    300                 305                 310                           

gcc ttt gat ggc ttt gat ttt ggc gat gat cct agt gac aag ttt ttc       1131
Ala Phe Asp Gly Phe Asp Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe           
315                 320                 325                 330           

aca tcc cat aat ggc atg cag ttc agt acc tgg gac aat gac aat gat       1179
Thr Ser His Asn Gly Met Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp           
                335                 340                 345               

aag ttt gaa ggc aac tgt gct gaa cag gat gga tct ggt tgg tgg atg       1227
Lys Phe Glu Gly Asn Cys Ala Glu Gln Asp Gly Ser Gly Trp Trp Met           
            350                 355                 360                   

aac aag tgt cac gct ggc cat ctc aat gga gtt tat tac caa ggt ggc       1275
Asn Lys Cys His Ala Gly His Leu Asn Gly Val Tyr Tyr Gln Gly Gly           
        365                 370                 375                       

act tac tca aaa gca tct act cct aat ggt tat gat aat ggc att att       1323
Thr Tyr Ser Lys Ala Ser Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile           
    380                 385                 390                           

tgg gcc act tgg aaa acc cgg tgg tat tcc atg aag aaa acc act atg       1371
Trp Ala Thr Trp Lys Thr Arg Trp Tyr Ser Met Lys Lys Thr Thr Met           
395                 400                 405                 410           

aag ata atc cca ttc aac aga ctc aca att gga gaa gga cag caa cac       1419
Lys Ile Ile Pro Phe Asn Arg Leu Thr Ile Gly Glu Gly Gln Gln His           
                415                 420                 425               

cac ctg ggg gga gcc aaa cag gtc aga cca gag cac cct gcg gaa aca       1467
His Leu Gly Gly Ala Lys Gln Val Arg Pro Glu His Pro Ala Glu Thr           
            430                 435                 440                   

gaa tat gac tca ctt tac cct gag gat gat ttg tag aaaattaact            1513
Glu Tyr Asp Ser Leu Tyr Pro Glu Asp Asp Leu                               
        445                 450                                           

gctaacttct attgacccac aaagtttcag aaattctctg aaagtttctt ccttttttct     1573

cttactatat ttattgattt caagtcttct attaaggaca tttagccttc aatggaaatt     1633

aaaactcatt taggactgta tttccaaatt actgatatca gagttattta aaaattgttt     1693

atttgaggag ataacatttc aactttgttc ctaaatatat aataataaaa tgattgactt     1753

tatttgcaaa                                                            1763


<210>  740
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  740

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu 
            180                 185                 190         


Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys 
        195                 200                 205             


Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu 
    210                 215                 220                 


Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly 
225                 230                 235                 240 


Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn 
                245                 250                 255     


Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu 
            260                 265                 270         


Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr 
        275                 280                 285             


Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr 
    290                 295                 300                 


Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp 
305                 310                 315                 320 


Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met 
                325                 330                 335     


Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys 
            340                 345                 350         


Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly 
        355                 360                 365             


His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser 
    370                 375                 380                 


Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr 
385                 390                 395                 400 


Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn 
                405                 410                 415     


Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys 
            420                 425                 430         


Gln Val Arg Pro Glu His Pro Ala Glu Thr Glu Tyr Asp Ser Leu Tyr 
        435                 440                 445             


Pro Glu Asp Asp Leu 
    450             


<210>  741
<211>  2262
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (92)..(1660)

<400>  741
gtgaggctgc gcttgcccgg ggcccgcgcc cccctacccc ggggaccgcc cccgggccgc       60

ccgccccact tggcgcgcca cttccgcgtg c atg gcc ctg ctg ccc cga gcc         112
                                   Met Ala Leu Leu Pro Arg Ala            
                                   1               5                      

ctg agc gcc ggc gcg gga ccg agc tgg cgg cgg gcg gcg cgc gcc ttc        160
Leu Ser Ala Gly Ala Gly Pro Ser Trp Arg Arg Ala Ala Arg Ala Phe           
        10                  15                  20                        

cga ggc ttc ctg ctg ctt ctg ccc gag ccc gcg gcc ctc acg cgc gcc        208
Arg Gly Phe Leu Leu Leu Leu Pro Glu Pro Ala Ala Leu Thr Arg Ala           
    25                  30                  35                            

ctc tcc cgt gcc atg gcc tgc agg cag gag ccg cag ccg cag ggc ccg        256
Leu Ser Arg Ala Met Ala Cys Arg Gln Glu Pro Gln Pro Gln Gly Pro           
40                  45                  50                  55            

ccg ccc gct gct ggc gcc gtg gcc tcc tat gac tac ctg gtg atc ggg        304
Pro Pro Ala Ala Gly Ala Val Ala Ser Tyr Asp Tyr Leu Val Ile Gly           
                60                  65                  70                

ggc ggc tcg ggc ggg ctg gcc agc gcg cgc agg gcg gcc gag ctg ggt        352
Gly Gly Ser Gly Gly Leu Ala Ser Ala Arg Arg Ala Ala Glu Leu Gly           
            75                  80                  85                    

gcc agg gcc gcc gtg gtg gag agc cac aag ctg ggt ggc act tgc gtg        400
Ala Arg Ala Ala Val Val Glu Ser His Lys Leu Gly Gly Thr Cys Val           
        90                  95                  100                       

aat gtt gga tgt gta ccc aaa aag gta atg tgg aac aca gct gtc cac        448
Asn Val Gly Cys Val Pro Lys Lys Val Met Trp Asn Thr Ala Val His           
    105                 110                 115                           

tct gaa ttc atg cat gat cat gct gat tat ggc ttt cca agt tgt gag        496
Ser Glu Phe Met His Asp His Ala Asp Tyr Gly Phe Pro Ser Cys Glu           
120                 125                 130                 135           

ggt aaa ttc aat tgg cgt gtt att aag gaa aag cgg gat gcc tat gtg        544
Gly Lys Phe Asn Trp Arg Val Ile Lys Glu Lys Arg Asp Ala Tyr Val           
                140                 145                 150               

agc cgc ctg aat gcc atc tat caa aac aat ctc acc aag tcc cat ata        592
Ser Arg Leu Asn Ala Ile Tyr Gln Asn Asn Leu Thr Lys Ser His Ile           
            155                 160                 165                   

gaa atc atc cgt ggc cat gca gcc ttc acg agt gat ccc aag ccc aca        640
Glu Ile Ile Arg Gly His Ala Ala Phe Thr Ser Asp Pro Lys Pro Thr           
        170                 175                 180                       

ata gag gtc agt ggg aaa aag tac acc gcc cca cac atc ctg atc gcc        688
Ile Glu Val Ser Gly Lys Lys Tyr Thr Ala Pro His Ile Leu Ile Ala           
    185                 190                 195                           

aca ggt ggt atg ccc tcc acc cct cat gag agc cag atc ccc ggt gcc        736
Thr Gly Gly Met Pro Ser Thr Pro His Glu Ser Gln Ile Pro Gly Ala           
200                 205                 210                 215           

agc tta gga ata acc agc gat gga ttt ttt cag ctg gaa gaa ttg ccc        784
Ser Leu Gly Ile Thr Ser Asp Gly Phe Phe Gln Leu Glu Glu Leu Pro           
                220                 225                 230               

ggc cgc agc gtc att gtt ggt gca ggt tac att gct gtg gag atg gca        832
Gly Arg Ser Val Ile Val Gly Ala Gly Tyr Ile Ala Val Glu Met Ala           
            235                 240                 245                   

ggg atc ctg tca gcc ctg ggt tct aag aca tca ctg atg ata cgg cat        880
Gly Ile Leu Ser Ala Leu Gly Ser Lys Thr Ser Leu Met Ile Arg His           
        250                 255                 260                       

gat aag gta ctt aga agt ttt gat tca atg atc agc acc aac tgc acg        928
Asp Lys Val Leu Arg Ser Phe Asp Ser Met Ile Ser Thr Asn Cys Thr           
    265                 270                 275                           

gag gag ctg gag aac gct ggc gtg gag gtg ctg aag ttc tcc cag gtc        976
Glu Glu Leu Glu Asn Ala Gly Val Glu Val Leu Lys Phe Ser Gln Val           
280                 285                 290                 295           

aag gag gtt aaa aag act ttg tcg ggc ttg gaa gtc agc atg gtt act       1024
Lys Glu Val Lys Lys Thr Leu Ser Gly Leu Glu Val Ser Met Val Thr           
                300                 305                 310               

gca gtt ccc ggt agg cta cca gtc atg acc atg att cca gat gtt gac       1072
Ala Val Pro Gly Arg Leu Pro Val Met Thr Met Ile Pro Asp Val Asp           
            315                 320                 325                   

tgc ctg ctc tgg gcc att ggg cgg gtc ccg aat acc aag gac ctg agt       1120
Cys Leu Leu Trp Ala Ile Gly Arg Val Pro Asn Thr Lys Asp Leu Ser           
        330                 335                 340                       

tta aac aaa ctg ggg att caa acc gat gac aag ggt cat atc atc gta       1168
Leu Asn Lys Leu Gly Ile Gln Thr Asp Asp Lys Gly His Ile Ile Val           
    345                 350                 355                           

gac gaa ttc cag aat acc aac gtc aaa ggc atc tat gca gtt ggg gat       1216
Asp Glu Phe Gln Asn Thr Asn Val Lys Gly Ile Tyr Ala Val Gly Asp           
360                 365                 370                 375           

gta tgt gga aaa gct ctt ctt act cca gtt gca ata gct gct ggc cga       1264
Val Cys Gly Lys Ala Leu Leu Thr Pro Val Ala Ile Ala Ala Gly Arg           
                380                 385                 390               

aaa ctt gcc cat cga ctt ttt gaa tat aag gaa gat tcc aaa tta gat       1312
Lys Leu Ala His Arg Leu Phe Glu Tyr Lys Glu Asp Ser Lys Leu Asp           
            395                 400                 405                   

tat aac aac atc cca act gtg gtc ttc agc cac ccc cct att ggg aca       1360
Tyr Asn Asn Ile Pro Thr Val Val Phe Ser His Pro Pro Ile Gly Thr           
        410                 415                 420                       

gtg gga ctc acg gaa gat gaa gcc att cat aaa tat gga ata gaa aat       1408
Val Gly Leu Thr Glu Asp Glu Ala Ile His Lys Tyr Gly Ile Glu Asn           
    425                 430                 435                           

gtg aag acc tat tca acg agc ttt acc ccg atg tat cac gca gtt acc       1456
Val Lys Thr Tyr Ser Thr Ser Phe Thr Pro Met Tyr His Ala Val Thr           
440                 445                 450                 455           

aaa agg aaa aca aaa tgt gtg atg aaa atg gtc tgt gct aac aag gaa       1504
Lys Arg Lys Thr Lys Cys Val Met Lys Met Val Cys Ala Asn Lys Glu           
                460                 465                 470               

gaa aag gtg gtt ggg atc cat atg cag gga ctt ggg tgt gat gaa atg       1552
Glu Lys Val Val Gly Ile His Met Gln Gly Leu Gly Cys Asp Glu Met           
            475                 480                 485                   

ctg cag ggt ttt gct gtt gca gtg aag atg gga gca acg aag gca gac       1600
Leu Gln Gly Phe Ala Val Ala Val Lys Met Gly Ala Thr Lys Ala Asp           
        490                 495                 500                       

ttt gac aac aca gtc gcc att cac cct acc tct tca gaa gag ctg gtc       1648
Phe Asp Asn Thr Val Ala Ile His Pro Thr Ser Ser Glu Glu Leu Val           
    505                 510                 515                           

aca ctt cgt tga gaaccaggag acacgtgtgg cgggcagtgg gacccataga           1700
Thr Leu Arg                                                               
520                                                                       

tcttctgaaa tgaaacaaat aatcacattg acttactgtt tgagttttat gtatttcttt     1760

attttaatca ggatcttctg atagtggaaa tttttagtac ataatagaac ttatttatgg     1820

agttagaaat ttgtagtgtt atccaggatt gattttcatt tgatcacatc tcacagtaat     1880

taatattttc aagttttttt tttattaaca gctctgtgct agtttttttt ttctgtttta     1940

gcctcatccc aaatataaag ctttgtgaag tacaattaac ttaatgtact tgaatgaata     2000

gaacttgcta cttttttttt tttttttttt gagacagagt tttgctctca ttgcccaggc     2060

tggagtgcgg tggtgctatt tcagctcacc acaacctctg cctcctgggt tcaagtgatt     2120

ctcctgcctt agcctcccga atagctggaa ttacaggcac gcaccaccat gcctgactaa     2180

ttttgtattt ttagtagaca tggggtttct ccatgttggt caggctggtc tcaaactccc     2240

accttcaggt gatccgccca cc                                              2262


<210>  742
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  742

Met Ala Leu Leu Pro Arg Ala Leu Ser Ala Gly Ala Gly Pro Ser Trp 
1               5                   10                  15      


Arg Arg Ala Ala Arg Ala Phe Arg Gly Phe Leu Leu Leu Leu Pro Glu 
            20                  25                  30          


Pro Ala Ala Leu Thr Arg Ala Leu Ser Arg Ala Met Ala Cys Arg Gln 
        35                  40                  45              


Glu Pro Gln Pro Gln Gly Pro Pro Pro Ala Ala Gly Ala Val Ala Ser 
    50                  55                  60                  


Tyr Asp Tyr Leu Val Ile Gly Gly Gly Ser Gly Gly Leu Ala Ser Ala 
65                  70                  75                  80  


Arg Arg Ala Ala Glu Leu Gly Ala Arg Ala Ala Val Val Glu Ser His 
                85                  90                  95      


Lys Leu Gly Gly Thr Cys Val Asn Val Gly Cys Val Pro Lys Lys Val 
            100                 105                 110         


Met Trp Asn Thr Ala Val His Ser Glu Phe Met His Asp His Ala Asp 
        115                 120                 125             


Tyr Gly Phe Pro Ser Cys Glu Gly Lys Phe Asn Trp Arg Val Ile Lys 
    130                 135                 140                 


Glu Lys Arg Asp Ala Tyr Val Ser Arg Leu Asn Ala Ile Tyr Gln Asn 
145                 150                 155                 160 


Asn Leu Thr Lys Ser His Ile Glu Ile Ile Arg Gly His Ala Ala Phe 
                165                 170                 175     


Thr Ser Asp Pro Lys Pro Thr Ile Glu Val Ser Gly Lys Lys Tyr Thr 
            180                 185                 190         


Ala Pro His Ile Leu Ile Ala Thr Gly Gly Met Pro Ser Thr Pro His 
        195                 200                 205             


Glu Ser Gln Ile Pro Gly Ala Ser Leu Gly Ile Thr Ser Asp Gly Phe 
    210                 215                 220                 


Phe Gln Leu Glu Glu Leu Pro Gly Arg Ser Val Ile Val Gly Ala Gly 
225                 230                 235                 240 


Tyr Ile Ala Val Glu Met Ala Gly Ile Leu Ser Ala Leu Gly Ser Lys 
                245                 250                 255     


Thr Ser Leu Met Ile Arg His Asp Lys Val Leu Arg Ser Phe Asp Ser 
            260                 265                 270         


Met Ile Ser Thr Asn Cys Thr Glu Glu Leu Glu Asn Ala Gly Val Glu 
        275                 280                 285             


Val Leu Lys Phe Ser Gln Val Lys Glu Val Lys Lys Thr Leu Ser Gly 
    290                 295                 300                 


Leu Glu Val Ser Met Val Thr Ala Val Pro Gly Arg Leu Pro Val Met 
305                 310                 315                 320 


Thr Met Ile Pro Asp Val Asp Cys Leu Leu Trp Ala Ile Gly Arg Val 
                325                 330                 335     


Pro Asn Thr Lys Asp Leu Ser Leu Asn Lys Leu Gly Ile Gln Thr Asp 
            340                 345                 350         


Asp Lys Gly His Ile Ile Val Asp Glu Phe Gln Asn Thr Asn Val Lys 
        355                 360                 365             


Gly Ile Tyr Ala Val Gly Asp Val Cys Gly Lys Ala Leu Leu Thr Pro 
    370                 375                 380                 


Val Ala Ile Ala Ala Gly Arg Lys Leu Ala His Arg Leu Phe Glu Tyr 
385                 390                 395                 400 


Lys Glu Asp Ser Lys Leu Asp Tyr Asn Asn Ile Pro Thr Val Val Phe 
                405                 410                 415     


Ser His Pro Pro Ile Gly Thr Val Gly Leu Thr Glu Asp Glu Ala Ile 
            420                 425                 430         


His Lys Tyr Gly Ile Glu Asn Val Lys Thr Tyr Ser Thr Ser Phe Thr 
        435                 440                 445             


Pro Met Tyr His Ala Val Thr Lys Arg Lys Thr Lys Cys Val Met Lys 
    450                 455                 460                 


Met Val Cys Ala Asn Lys Glu Glu Lys Val Val Gly Ile His Met Gln 
465                 470                 475                 480 


Gly Leu Gly Cys Asp Glu Met Leu Gln Gly Phe Ala Val Ala Val Lys 
                485                 490                 495     


Met Gly Ala Thr Lys Ala Asp Phe Asp Asn Thr Val Ala Ile His Pro 
            500                 505                 510         


Thr Ser Ser Glu Glu Leu Val Thr Leu Arg 
        515                 520         


<210>  743
<211>  1681
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (38)..(643)

<400>  743
ggggcgtgaa gggagccggg atcagccagg ggccagc atg agc cgg agg gag gga        55
                                         Met Ser Arg Arg Glu Gly          
                                         1               5                

agt ctg gaa gac ccc cag act gat tcc tca gtc tca ctt ctt ccc cac        103
Ser Leu Glu Asp Pro Gln Thr Asp Ser Ser Val Ser Leu Leu Pro His           
            10                  15                  20                    

ttg gag gcc aag atc cgt cag aca cac agc ctt gcg cac ctc ctc acc        151
Leu Glu Ala Lys Ile Arg Gln Thr His Ser Leu Ala His Leu Leu Thr           
        25                  30                  35                        

aaa tac gct gag cag ctg ctc cag gaa tat gtg cag ctc cag gga gac        199
Lys Tyr Ala Glu Gln Leu Leu Gln Glu Tyr Val Gln Leu Gln Gly Asp           
    40                  45                  50                            

ccc ttc ggg ctg ccc agc ttc tcg ccg ccg cgg ctg ccg gtg gcc ggc        247
Pro Phe Gly Leu Pro Ser Phe Ser Pro Pro Arg Leu Pro Val Ala Gly           
55                  60                  65                  70            

ctg agc gcc ccg gct ccg agc cac gcg ggg ctg cca gtg cac gag cgg        295
Leu Ser Ala Pro Ala Pro Ser His Ala Gly Leu Pro Val His Glu Arg           
                75                  80                  85                

ctg cgg ctg gac gcg gcg gcg ctg gcc gcg ctg ccc ccg ctg ctg gac        343
Leu Arg Leu Asp Ala Ala Ala Leu Ala Ala Leu Pro Pro Leu Leu Asp           
            90                  95                  100                   

gca gtg tgt cgc cgc cag gcc gag ctg aac ccg cgc gcg ccg cgc ctg        391
Ala Val Cys Arg Arg Gln Ala Glu Leu Asn Pro Arg Ala Pro Arg Leu           
        105                 110                 115                       

ctg cgc cgc ctg gag gac gcg gcg cgc cag gcc cgg gcc ctg ggc gcc        439
Leu Arg Arg Leu Glu Asp Ala Ala Arg Gln Ala Arg Ala Leu Gly Ala           
    120                 125                 130                           

gcc gtg gag gcc ttg ctg gcc gcg ctg ggc gcc gcc aac cgc ggg ccc        487
Ala Val Glu Ala Leu Leu Ala Ala Leu Gly Ala Ala Asn Arg Gly Pro           
135                 140                 145                 150           

cgg gcc gag ccc ccc gcc gcc acc gcc tca gcc gcc tcc gcc acc ggg        535
Arg Ala Glu Pro Pro Ala Ala Thr Ala Ser Ala Ala Ser Ala Thr Gly           
                155                 160                 165               

gtc ttc ccc gcc aag gtg ctg ggg ctc cgc gtt tgc ggc ctc tac cgc        583
Val Phe Pro Ala Lys Val Leu Gly Leu Arg Val Cys Gly Leu Tyr Arg           
            170                 175                 180                   

gag tgg ctg agc cgc acc gag ggc gac ctg ggc cag ctg ctg ccc ggg        631
Glu Trp Leu Ser Arg Thr Glu Gly Asp Leu Gly Gln Leu Leu Pro Gly           
        185                 190                 195                       

ggc tcg gcc tga gcgccgcggg gcagctcgcc ccgcctcctc ccgctgggtt            683
Gly Ser Ala                                                               
    200                                                                   

ccgtctctcc ttccgcttct ttgtctttct ctgccgctgt cggtgtctgt ctgtctgctc      743

ttagctgtct ccattgcctc ggccttcttt gctttttgtg ggggagaggg gaggggacgg      803

gcagggtctc tgtcgcccag gctggggtgc agtggcgcga tcccagcact gcagcctcaa      863

cctcctgggc tcaagccatc cttccgcctc agcttcccca gcagctggga ctacaggcac      923

gcgccaccac agccggctaa ttttttattt aattttttgt agagacgagg tttcgccatg      983

ttgcccaggc tggtcttgaa ctccggggct caagcgatcc tcccgcttca gcctccctaa     1043

gtgctgggat tgcaggcgtg agccactttc ccagcctctc tttgctttgc ctgccccgtt     1103

ctcttaactc ttggaccctc ctcgtctgca tggtaactcc gtctgagtct accattttct     1163

tgctctccct ccttccttgg gcctgcctca gttccctttg gcctccccct ttacccagct     1223

cttggggtgt ctctgttttt tccatcccca cttcctgcct tctcgtggcc ctgtgtgagc     1283

acatgtgtac atctcagcct tatctcaagg aggtgacacc ttctctcctt gtccccatct     1343

ggccgtctct ctgtgcttcc ctggccaggg gcgtgcctgc tggtcctatg gggggaaggc     1403

tactctgcat ctcagccacc ttcctcaggc tcactccacc tacatcccca gtctgccaca     1463

ccccatccct ttgggcctca gccctgtccc tttgatgtcc tcctttcctt cagcccctct     1523

gccctgtccc tgcacacctc cactgcctcc cagcagatct gtggagacaa aacaagcaac     1583

accttaaaag agttttattt ctgaaaataa attaattttt tgtaaataaa atgtttaaaa     1643

ataaaaaaga aactaaagtt aaaaaaaaaa aaaaaaaa                             1681


<210>  744
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  744

Met Ser Arg Arg Glu Gly Ser Leu Glu Asp Pro Gln Thr Asp Ser Ser 
1               5                   10                  15      


Val Ser Leu Leu Pro His Leu Glu Ala Lys Ile Arg Gln Thr His Ser 
            20                  25                  30          


Leu Ala His Leu Leu Thr Lys Tyr Ala Glu Gln Leu Leu Gln Glu Tyr 
        35                  40                  45              


Val Gln Leu Gln Gly Asp Pro Phe Gly Leu Pro Ser Phe Ser Pro Pro 
    50                  55                  60                  


Arg Leu Pro Val Ala Gly Leu Ser Ala Pro Ala Pro Ser His Ala Gly 
65                  70                  75                  80  


Leu Pro Val His Glu Arg Leu Arg Leu Asp Ala Ala Ala Leu Ala Ala 
                85                  90                  95      


Leu Pro Pro Leu Leu Asp Ala Val Cys Arg Arg Gln Ala Glu Leu Asn 
            100                 105                 110         


Pro Arg Ala Pro Arg Leu Leu Arg Arg Leu Glu Asp Ala Ala Arg Gln 
        115                 120                 125             


Ala Arg Ala Leu Gly Ala Ala Val Glu Ala Leu Leu Ala Ala Leu Gly 
    130                 135                 140                 


Ala Ala Asn Arg Gly Pro Arg Ala Glu Pro Pro Ala Ala Thr Ala Ser 
145                 150                 155                 160 


Ala Ala Ser Ala Thr Gly Val Phe Pro Ala Lys Val Leu Gly Leu Arg 
                165                 170                 175     


Val Cys Gly Leu Tyr Arg Glu Trp Leu Ser Arg Thr Glu Gly Asp Leu 
            180                 185                 190         


Gly Gln Leu Leu Pro Gly Gly Ser Ala 
        195                 200     


<210>  745
<211>  1916
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (225)..(1088)

<400>  745
atggcgccgt gcgtggcctc ggcggtggcg cagggggcgg gcccgcggcg cggcgccgga       60

ggaggaagtg gtgaggttgt tgctccttca gcgcctatcg ctggctcttg gggcgcagag      120

aggggccgca gtctccgcgg ctgcgtcgag ctcccttgca gtcccctcca tgttccccgg      180

cgccactact ccccttccta aggccgccgc ttaccccggg gtct atg gaa gta atg       236
                                                 Met Glu Val Met          
                                                 1                        

gaa gga ccc ctc aac ctg gct cat caa cag agc aga cga gca gac cgt        284
Glu Gly Pro Leu Asn Leu Ala His Gln Gln Ser Arg Arg Ala Asp Arg           
5                   10                  15                  20            

tta tta gct gca ggc aaa tac gaa gag gct att tct tgt cac aaa aag        332
Leu Leu Ala Ala Gly Lys Tyr Glu Glu Ala Ile Ser Cys His Lys Lys           
                25                  30                  35                

gct gca gca tat ctt tct gaa gcc atg aag ctg aca cag tca gag cag        380
Ala Ala Ala Tyr Leu Ser Glu Ala Met Lys Leu Thr Gln Ser Glu Gln           
            40                  45                  50                    

gct cat ctt tca ctg gaa ttg caa agg gat agc cat atg aaa cag ctc        428
Ala His Leu Ser Leu Glu Leu Gln Arg Asp Ser His Met Lys Gln Leu           
        55                  60                  65                        

ctc ctc atc caa gag aga tgg aaa agg gcc cag cgt gaa gaa aga ttg        476
Leu Leu Ile Gln Glu Arg Trp Lys Arg Ala Gln Arg Glu Glu Arg Leu           
    70                  75                  80                            

aaa gcc cag cag aac aca gac aag gat gca gct gcc cat ctt cag aca        524
Lys Ala Gln Gln Asn Thr Asp Lys Asp Ala Ala Ala His Leu Gln Thr           
85                  90                  95                  100           

tct cac aaa ccc tct gca gag gat gca gag ggc cag agt ccc ctt tct        572
Ser His Lys Pro Ser Ala Glu Asp Ala Glu Gly Gln Ser Pro Leu Ser           
                105                 110                 115               

cag aag tac agc cct tcc aca gag aaa tgc ctg cct gag att cag ggg        620
Gln Lys Tyr Ser Pro Ser Thr Glu Lys Cys Leu Pro Glu Ile Gln Gly           
            120                 125                 130                   

atc ttt gac agg gat cca gac aca cta ctt tat tta ctt cag caa aag        668
Ile Phe Asp Arg Asp Pro Asp Thr Leu Leu Tyr Leu Leu Gln Gln Lys           
        135                 140                 145                       

agt gag cca gca gag cca tgt att gga agc aaa gcc cca aaa gat gat        716
Ser Glu Pro Ala Glu Pro Cys Ile Gly Ser Lys Ala Pro Lys Asp Asp           
    150                 155                 160                           

aaa aca att ata gag gag cag gca acc aaa att gca gat ttg aag agg        764
Lys Thr Ile Ile Glu Glu Gln Ala Thr Lys Ile Ala Asp Leu Lys Arg           
165                 170                 175                 180           

cat gtg gaa ttc ctt gtg gct gag aat gaa aga tta agg aaa gaa aat        812
His Val Glu Phe Leu Val Ala Glu Asn Glu Arg Leu Arg Lys Glu Asn           
                185                 190                 195               

aaa caa cta aag gct gaa aag gcc aga ctt cta aaa ggt cca ata gaa        860
Lys Gln Leu Lys Ala Glu Lys Ala Arg Leu Leu Lys Gly Pro Ile Glu           
            200                 205                 210                   

aag gag ctg gat gta gat gct gat ttt gta gaa acg tca gag tta tgg        908
Lys Glu Leu Asp Val Asp Ala Asp Phe Val Glu Thr Ser Glu Leu Trp           
        215                 220                 225                       

agc ttg cca cca cat gca gaa act gct aca gcc tcc tca acc tgg cag        956
Ser Leu Pro Pro His Ala Glu Thr Ala Thr Ala Ser Ser Thr Trp Gln           
    230                 235                 240                           

aag ttc gca gca aat act ggg aaa gcc aag gac att cca atc ccc aat       1004
Lys Phe Ala Ala Asn Thr Gly Lys Ala Lys Asp Ile Pro Ile Pro Asn           
245                 250                 255                 260           

ctt cct ccc ttg gat ttt cca tct cca gaa ctt cct ctt atg gag ctc       1052
Leu Pro Pro Leu Asp Phe Pro Ser Pro Glu Leu Pro Leu Met Glu Leu           
                265                 270                 275               

tct gag gat att ctg aaa gga ttt atg aat aat taa aatggaaggc            1098
Ser Glu Asp Ile Leu Lys Gly Phe Met Asn Asn                               
            280                 285                                       

cacagaaaag gggaaaagag gaaataatac agtaatcgtt aatccagcaa aaagaaatga     1158

aaagggaaaa ccacatagaa gggtaatccc ggaaatgctt catctggtgg actgtgggag     1218

cagaggcatt gccaggactt gggaaacagt cactgtgaaa tgcgctgcgt atctcattca     1278

ctcacttcag ctaatgattc cgacttggca gacgctaaac tcatggaggt tcggtttctc     1338

ctgatacaaa ccaaatggct acctggaaga atttctttca agcaacagtt atttttctta     1398

tcttcagggt taaaatgtat aaaagttatg tgtaattaat ctataatgcc ataaatgata     1458

atgcaaaacc taaataatat ggtggccgga ggggctgcct tatatttgaa acatgctttc     1518

tatcatgcat tgactgtatg cattttgtta atgcacattc tgtttgttta aggtgtgtaa     1578

gatacacacc cttctagatg aaactatatg tgccacactt tgcactactc ataatgataa     1638

cctcaagact atcagaagaa atatttaaat ttccatttta tgaagaaagg aaccaaatta     1698

ttatgctttt taaaacaaat taccagttta cataattaat cagggtgcat tttaagttct     1758

aacttcgttt attgtataat gcatcatttg aaaataccaa ggaggaaata ccctttgttt     1818

ttaatgatgc aagagtggac gtaatgctag ttggcagtat tttattgtaa gaaatcaata     1878

aagtaattgt gttttataaa aaaaaaaaaa aaaaaaaa                             1916


<210>  746
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  746

Met Glu Val Met Glu Gly Pro Leu Asn Leu Ala His Gln Gln Ser Arg 
1               5                   10                  15      


Arg Ala Asp Arg Leu Leu Ala Ala Gly Lys Tyr Glu Glu Ala Ile Ser 
            20                  25                  30          


Cys His Lys Lys Ala Ala Ala Tyr Leu Ser Glu Ala Met Lys Leu Thr 
        35                  40                  45              


Gln Ser Glu Gln Ala His Leu Ser Leu Glu Leu Gln Arg Asp Ser His 
    50                  55                  60                  


Met Lys Gln Leu Leu Leu Ile Gln Glu Arg Trp Lys Arg Ala Gln Arg 
65                  70                  75                  80  


Glu Glu Arg Leu Lys Ala Gln Gln Asn Thr Asp Lys Asp Ala Ala Ala 
                85                  90                  95      


His Leu Gln Thr Ser His Lys Pro Ser Ala Glu Asp Ala Glu Gly Gln 
            100                 105                 110         


Ser Pro Leu Ser Gln Lys Tyr Ser Pro Ser Thr Glu Lys Cys Leu Pro 
        115                 120                 125             


Glu Ile Gln Gly Ile Phe Asp Arg Asp Pro Asp Thr Leu Leu Tyr Leu 
    130                 135                 140                 


Leu Gln Gln Lys Ser Glu Pro Ala Glu Pro Cys Ile Gly Ser Lys Ala 
145                 150                 155                 160 


Pro Lys Asp Asp Lys Thr Ile Ile Glu Glu Gln Ala Thr Lys Ile Ala 
                165                 170                 175     


Asp Leu Lys Arg His Val Glu Phe Leu Val Ala Glu Asn Glu Arg Leu 
            180                 185                 190         


Arg Lys Glu Asn Lys Gln Leu Lys Ala Glu Lys Ala Arg Leu Leu Lys 
        195                 200                 205             


Gly Pro Ile Glu Lys Glu Leu Asp Val Asp Ala Asp Phe Val Glu Thr 
    210                 215                 220                 


Ser Glu Leu Trp Ser Leu Pro Pro His Ala Glu Thr Ala Thr Ala Ser 
225                 230                 235                 240 


Ser Thr Trp Gln Lys Phe Ala Ala Asn Thr Gly Lys Ala Lys Asp Ile 
                245                 250                 255     


Pro Ile Pro Asn Leu Pro Pro Leu Asp Phe Pro Ser Pro Glu Leu Pro 
            260                 265                 270         


Leu Met Glu Leu Ser Glu Asp Ile Leu Lys Gly Phe Met Asn Asn 
        275                 280                 285         


<210>  747
<211>  7370
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (220)..(696)

<400>  747
ttttgtagat aaatgtgagg attttctcta aatccctctt ctgtttgcta aatctcactg       60

tcactgctaa attcagagca gatagagcct gcgcaatgga ataaagtcct caaaattgaa      120

atgtgacatt gctctcaaca tctcccatct ctctggattt ctttttgctt cattattcct      180

gctaaccaat tcattttcag actttgtact tcagaagca atg gga aaa atc agc         234
                                           Met Gly Lys Ile Ser            
                                           1               5              

agt ctt cca acc caa tta ttt aag tgc tgc ttt tgt gat ttc ttg aag        282
Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe Cys Asp Phe Leu Lys           
                10                  15                  20                

gtg aag atg cac acc atg tcc tcc tcg cat ctc ttc tac ctg gcg ctg        330
Val Lys Met His Thr Met Ser Ser Ser His Leu Phe Tyr Leu Ala Leu           
            25                  30                  35                    

tgc ctg ctc acc ttc acc agc tct gcc acg gct gga ccg gag acg ctc        378
Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala Gly Pro Glu Thr Leu           
        40                  45                  50                        

tgc ggg gct gag ctg gtg gat gct ctt cag ttc gtg tgt gga gac agg        426
Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly Asp Arg           
    55                  60                  65                            

ggc ttt tat ttc aac aag ccc aca ggg tat ggc tcc agc agt cgg agg        474
Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg           
70                  75                  80                  85            

gcg cct cag aca ggc atc gtg gat gag tgc tgc ttc cgg agc tgt gat        522
Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys Asp           
                90                  95                  100               

cta agg agg ctg gag atg tat tgc gca ccc ctc aag cct gcc aag tca        570
Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys Ser           
            105                 110                 115                   

gct cgc tct gtc cgt gcc cag cgc cac acc gac atg ccc aag acc cag        618
Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp Met Pro Lys Thr Gln           
        120                 125                 130                       

aag tat cag ccc cca tct acc aac aag aac acg aag tct cag aga agg        666
Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr Lys Ser Gln Arg Arg           
    135                 140                 145                           

aaa gga agt aca ttt gaa gaa cgc aag tag agggagtgca ggaaacaaga          716
Lys Gly Ser Thr Phe Glu Glu Arg Lys                                       
150                 155                                                   

actacaggat gtaggaagac cctcctgagg agtgaagagt gacatgccac cgcaggatcc      776

tttgctctgc acgagttacc tgttaaactt tggaacacct accaaaaaat aagtttgata      836

acatttaaaa gatgggcgtt tcccccaatg aaatacacaa gtaaacattc caacattgtc      896

tttaggagtg atttgcacct tgcaaaaatg gtcctggagt tggtagattg ctgttgatct      956

tttatcaata atgttctata gaaaagaaaa aaaaaatata tatatatata tatcttagtc     1016

cctgcctctc aagagccaca aatgcatggg tgttgtatag atccagttgc actaaattcc     1076

tctctgaatc ttggctgctg gagccattca ttcagcaacc ttgtctaagt ggtttatgaa     1136

ttgtttcctt atttgcactt ctttctacac aactcgggct gtttgtttta cagtgtctga     1196

taatcttgtt agtctatacc caccacctcc cttcataacc tttatatttg ccgaatttgg     1256

cctcctcaaa agcagcagca agtcgtcaag aagcacacca attctaaccc acaagattcc     1316

atctgtggca tttgtaccaa atataagttg gatgcatttt attttagaca caaagcttta     1376

tttttccaca tcatgcttac aaaaaagaat aatgcaaata gttgcaactt tgaggccaat     1436

catttttagg catatgtttt aaacatagaa agtttcttca actcaaaaga gttccttcaa     1496

atgatgagtt aatgtgcaac ctaattagta actttcctct ttttattttt tccatataga     1556

gcactatgta aatttagcat atcaattata caggatatat caaacagtat gtaaaactct     1616

gttttttagt ataatggtgc tattttgtag tttgttatat gaaagagtct ggccaaaacg     1676

gtaatacgtg aaagcaaaac aataggggaa gcctggagcc aaagatgaca caaggggaag     1736

ggtactgaaa acaccatcca tttgggaaag aaggcaaagt ccccccagtt atgccttcca     1796

agaggaactt cagacacaaa agtccactga tgcaaattgg actggcgagt ccagagagga     1856

aactgtggaa tggaaaaagc agaaggctag gaattttagc agtcctggtt tctttttctc     1916

atggaagaaa tgaacatctg ccagctgtgt catggactca ccactgtgtg accttgggca     1976

agtcacttca cctctctgtg cctcagtttc ctcatctgca aaatgggggc aatatgtcat     2036

ctacctacct caaaggggtg gtataaggtt taaaaagata aagattcaga ttttttttac     2096

cctgggttgc tgtaagggtg caacatcagg gcgcttgagt tgctgagatg caaggaattc     2156

tataaataac ccattcatag catagctaga gattggtgaa ttgaatgctc ctgacatctc     2216

agttcttgtc agtgaagcta tccaaataac tggccaacta gttgttaaaa gctaacagct     2276

caatctctta aaacactttt caaaatatgt gggaagcatt tgattttcaa tttgattttg     2336

aattctgcat ttggttttat gaatacaaag ataagtgaaa agagagaaag gaaaagaaaa     2396

aggagaaaaa caaagagatt tctaccagtg aaaggggaat taattactct ttgttagcac     2456

tcactgactc ttctatgcag ttactacata tctagtaaaa cctcgtttaa tactataaat     2516

aatattctat tcattttgaa aaacacaatg attccttctt ttctaggcaa tataaggaaa     2576

gtgatccaaa atttgaaata ttaaaataat atctaataaa aagtcacaaa gttatcttct     2636

ttaacaaact ttactcttat tcttagctgt atatacattt ttttaaaagt ttgttaaaat     2696

atgcttgact agagtttcca gttgaaaggc aaaaacttcc atcacaacaa gaaatttccc     2756

atgcctgctc agaagggtag cccctagctc tctgtgaatg tgttttatcc attcaactga     2816

aaattggtat caagaaagtc cactggttag tgtactagtc catcatagcc tagaaaatga     2876

tccctatctg cagatcaaga ttttctcatt agaacaatga attatccagc attcagatct     2936

ttctagtcac cttagaactt tttggttaaa agtacccagg cttgattatt tcatgcaaat     2996

tctatatttt acattcttgg aaagtctata tgaaaaacaa aaataacatc ttcagttttt     3056

ctcccactgg gtcacctcaa ggatcagagg ccaggaaaaa aaaaaaaaag actccctgga     3116

tctctgaata tatgcaaaaa gaaggcccca tttagtggag ccagcaatcc tgttcagtca     3176

acaagtattt taactctcag tccaacatta tttgaattga gcacctcaag catgcttagc     3236

aatgttctaa tcactatgga cagatgtaaa agaaactata catcattttt gccctctgcc     3296

tgttttccag acatacaggt tctgtggaat aagatactgg actcctcttc ccaagatggc     3356

acttcttttt atttcttgtc cccagtgtgt accttttaaa attattccct ctcaacaaaa     3416

ctttataggc agtcttctgc agacttaacg tgttttctgt catagttaga tgtgataatt     3476

ctaagagtgt ctatgactta tttccttcac ttaattctat ccacagtcaa aaatccccca     3536

aggaggaaag ctgaaagatg cactgccata ttatctttct taactttttc caacacataa     3596

tcctctccaa ctggattata aataaattga aaataactca ttataccaat tcactatttt     3656

attttttaat gaattaaaac tagaaaacaa attgatgcaa accctggaag tcagttgatt     3716

actatatact acagcagaat gactcagatt tcatagaaag gagcaaccaa aatgtcacaa     3776

cccaaaactt tacaagcttt gcttcagaat tagattgctt tataattctt gaatgaggca     3836

atttcaagat atttgtaaaa gaacagtaaa cattggtaag aatgagcttt caactcatag     3896

gcttatttcc aatttaattg accatactgg atacttaggt caaatttctg ttctctcttc     3956

cccaaataat attaaagtat tatttgaact ttttaagatg aggcagttcc cctgaaaaag     4016

ttaatgcagc tctccatcag aatccactct tctagggata tgaaaatctc ttaacaccca     4076

ccctacatac acagacacac acacacacac acacacacac acacacacac acattcaccc     4136

taaggatcca atggaatact gaaaagaaat cacttccttg aaaattttat taaaaaacaa     4196

acaaacaaac aaaaagcctg tccacccttg agaatccttc ctctccttgg aacgtcaatg     4256

tttgtgtaga tgaaaccatc tcatgctctg tggctccagg gtttctgtta ctattttatg     4316

cacttgggag aaggcttaga ataaaagatg tagcacattt tgctttccca tttattgttt     4376

ggccagctat gccaatgtgg tgctattgtt tctttaagaa agtacttgac taaaaaaaaa     4436

agaaaaaaag aaaaaaaaga aagcatagac atattttttt aaagtataaa aacaacaatt     4496

ctatagatag atggcttaat aaaatagcat taggtctatc tagccaccac cacctttcaa     4556

ctttttatca ctcacaagta gtgtactgtt caccaaattg tgaatttggg ggtgcagggg     4616

caggagttgg aaatttttta aagttagaag gctccattgt tttgttggct ctcaaactta     4676

gcaaaattag caatatatta tccaatcttc tgaacttgat caagagcatg gagaataaac     4736

gcgggaaaaa agatcttata ggcaaataga agaatttaaa agataagtaa gttccttatt     4796

gatttttgtg cactctgctc taaaacagat attcagcaag tggagaaaat aagaacaaag     4856

agaaaaaata catagattta cctgcaaaaa atagcttctg ccaaatcccc cttgggtatt     4916

ctttggcatt tactggttta tagaagacat tctcccttca cccagacatc tcaaagagca     4976

gtagctctca tgaaaagcaa tcactgatct catttgggaa atgttggaaa gtatttcctt     5036

atgagatggg ggttatctac tgataaagaa agaatttatg agaaattgtt gaaagagatg     5096

gctaacaatc tgtgaagatt ttttgtttct tgtttttgtt tttttttttt ttttacttta     5156

tacagtcttt atgaatttct taatgttcaa aatgacttgg ttcttttctt ctttttttat     5216

atcagaatga ggaataataa gttaaaccca catagactct ttaaaactat aggctagata     5276

gaaatgtatg tttgacttgt tgaagctata atcagactat ttaaaatgtt ttgctatttt     5336

taatcttaaa agattgtgct aatttattag agcagaacct gtttggctct cctcagaaga     5396

aagaatcttt ccattcaaat cacatggctt tccaccaata ttttcaaaag ataaatctga     5456

tttatgcaat ggcatcattt attttaaaac agaagaattg tgaaagttta tgcccctccc     5516

ttgcaaagac cataaagtcc agatctggta ggggggcaac aacaaaagga aaatgttgtt     5576

gattcttggt tttggatttt gttttgtttt caatgctagt gtttaatcct gtagtacata     5636

tttgcttatt gctattttaa tattttataa gaccttcctg ttaggtatta gaaagtgata     5696

catagatatc ttttttgtgt aatttctatt taaaaaagag agaagactgt cagaagcttt     5756

aagtgcatat ggtacaggat aaagatatca atttaaataa ccaattccta tctggaacaa     5816

tgcttttgtt ttttaaagaa acctctcaca gataagacag aggcccaggg gatttttgaa     5876

gctgtcttta ttctgccccc atcccaaccc agcccttatt attttagtat ctgcctcaga     5936

attttataga gggctgacca agctgaaact ctagaattaa aggaacctca ctgaaaacat     5996

atatttcacg tgttccctct tttttttttt cctttttgtg agatggggtc tcgcactgtc     6056

ccccaggctg gagtgcagtg gcatgatctc ggctcactgc aacctccacc tcctgggttt     6116

aagcgattct cctgcctcag cctcctgagt agctgggatt acaggcaccc accactatgc     6176

ccggctaatt ttttggattt ttaatagaga cggggtttta ccatgttggc caggttggtc     6236

tcaaactcct gaccttgtga tttgcccgcc tcagcctccc aaattgctgg gattacaggc     6296

atgagccacc acaccctgcc catgtgttcc ctcttaatgt atgattacat ggatcttaaa     6356

catgatcctt ctctcctcat tcttcaacta tctttgatgg ggtctttcaa ggggaaaaaa     6416

atccaagctt ttttaaagta aaaaaaaaaa aagagaggac acaaaaccaa atgttactgc     6476

tcaactgaaa tatgagttaa gatggagaca gagtttctcc taataaccgg agctgaatta     6536

cctttcactt tcaaaaacat gaccttccac aatccttaga atctgccttt ttttatatta     6596

ctgaggccta aaagtaaaca ttactcattt tattttgccc aaaatgcact gatgtaaagt     6656

aggaaaaata aaaacagagc tctaaaatcc ctttcaagcc acccattgac cccactcacc     6716

aactcatagc aaagtcactt ctgttaatcc cttaatctga ttttgtttgg atatttatct     6776

tgtacccgct gctaaacaca ctgcaggagg gactctgaaa cctcaagctg tctacttaca     6836

tcttttatct gtgtctgtgt atcatgaaaa tgtctattca aaatatcaaa acctttcaaa     6896

tatcacgcag cttatattca gtttacataa aggccccaaa taccatgtca gatctttttg     6956

gtaaaagagt taatgaacta tgagaattgg gattacatca tgtattttgc ctcatgtatt     7016

tttatcacac ttataggcca agtgtgataa ataaacttac agacactgaa ttaatttccc     7076

ctgctacttt gaaaccagaa aataatgact ggccattcgt tacatctgtc ttagttgaaa     7136

agcatatttt ttattaaatt aattctgatt gtatttgaaa ttattattca attcacttat     7196

ggcagaggaa tatcaatcct aatgacttct aaaaatgtaa ctaattgaat cattatctta     7256

catttactgt ttaataagca tattttgaaa atgtatggct agagtgtcat aataaaatgg     7316

tatatctttc tttagtaatt acattaaaat tagtcatgtt tgattaatta gttc           7370


<210>  748
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  748

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 
    130                 135                 140                 


Lys Ser Gln Arg Arg Lys Gly Ser Thr Phe Glu Glu Arg Lys 
145                 150                 155             


<210>  749
<211>  2628
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (114)..(1904)

<400>  749
gtgcgctgcc gtaccggtca cgtggacgtt tggtcacgtg actgcgtccg tggtcctccc       60

gtaggaaccg gcggactcgg ttggcgttgt ggggcagggg gtggtggagc aag atg         116
                                                           Met            
                                                           1              

gcg gct cat ctg tcc tac ggc cga gtg aac cta aac gtg ttg cgc gag        164
Ala Ala His Leu Ser Tyr Gly Arg Val Asn Leu Asn Val Leu Arg Glu           
            5                   10                  15                    

gcg gtg cgt cgc gag ctg cgc gag ttc ctg gac aag tgc gca gga agc        212
Ala Val Arg Arg Glu Leu Arg Glu Phe Leu Asp Lys Cys Ala Gly Ser           
        20                  25                  30                        

aag gca ata gtt tgg gat gaa tac cta act gga ccc ttt ggc ctg att        260
Lys Ala Ile Val Trp Asp Glu Tyr Leu Thr Gly Pro Phe Gly Leu Ile           
    35                  40                  45                            

gca cag tat tca cta ttg aag gaa cat gaa gtg gaa aaa atg ttc aca        308
Ala Gln Tyr Ser Leu Leu Lys Glu His Glu Val Glu Lys Met Phe Thr           
50                  55                  60                  65            

ctt aaa gga aat cgt ttg ccg gca gct gat gtg aag aat ata att ttt        356
Leu Lys Gly Asn Arg Leu Pro Ala Ala Asp Val Lys Asn Ile Ile Phe           
                70                  75                  80                

ttt gtc aga ccc agg cta gag ttg atg gat ata atc gct gaa aac gtg        404
Phe Val Arg Pro Arg Leu Glu Leu Met Asp Ile Ile Ala Glu Asn Val           
            85                  90                  95                    

ctc agt gaa gat aga cga ggc cca acg aga gat ttt cat att ctg ttt        452
Leu Ser Glu Asp Arg Arg Gly Pro Thr Arg Asp Phe His Ile Leu Phe           
        100                 105                 110                       

gtg cca cgc cgt agc ctg ttg tgc gaa cag cgg ttg aag gat ctg ggt        500
Val Pro Arg Arg Ser Leu Leu Cys Glu Gln Arg Leu Lys Asp Leu Gly           
    115                 120                 125                           

gtc ttg gga tcc ttt att cac agg gag gag tac agc tta gat ctc att        548
Val Leu Gly Ser Phe Ile His Arg Glu Glu Tyr Ser Leu Asp Leu Ile           
130                 135                 140                 145           

cca ttc gat ggg gat ctc tta tcc atg gaa tca gag ggt gca ttc aaa        596
Pro Phe Asp Gly Asp Leu Leu Ser Met Glu Ser Glu Gly Ala Phe Lys           
                150                 155                 160               

gag tgc tac ctg gag ggt gac cag acg agc ctg tac cac gca gcc aag        644
Glu Cys Tyr Leu Glu Gly Asp Gln Thr Ser Leu Tyr His Ala Ala Lys           
            165                 170                 175                   

ggg ctg atg acc ctg caa gct ctg tat gga acg atc ccc cag atc ttt        692
Gly Leu Met Thr Leu Gln Ala Leu Tyr Gly Thr Ile Pro Gln Ile Phe           
        180                 185                 190                       

ggg aaa gga gaa tgc gct cgg caa gtg gcc aat atg atg atc agg atg        740
Gly Lys Gly Glu Cys Ala Arg Gln Val Ala Asn Met Met Ile Arg Met           
    195                 200                 205                           

aag aga gag ttt aca gga agc cag aat tca ata ttt cct gtt ttt gat        788
Lys Arg Glu Phe Thr Gly Ser Gln Asn Ser Ile Phe Pro Val Phe Asp           
210                 215                 220                 225           

aat ctc ttg ttg ctt gat cgg aat gtg gat tta tta aca cct ctt gcc        836
Asn Leu Leu Leu Leu Asp Arg Asn Val Asp Leu Leu Thr Pro Leu Ala           
                230                 235                 240               

act cag ctg aca tat gaa gga ctc att gat gaa att tat ggc att cag        884
Thr Gln Leu Thr Tyr Glu Gly Leu Ile Asp Glu Ile Tyr Gly Ile Gln           
            245                 250                 255                   

aac agt tat gtg aaa tta cct cca gag aaa ttt gca cct aag aaa cag        932
Asn Ser Tyr Val Lys Leu Pro Pro Glu Lys Phe Ala Pro Lys Lys Gln           
        260                 265                 270                       

ggc gat ggt ggt aag gac ctc ccc acg gaa gca aag aag ctg cag ctg        980
Gly Asp Gly Gly Lys Asp Leu Pro Thr Glu Ala Lys Lys Leu Gln Leu           
    275                 280                 285                           

aat tct gca gag gag ctc tat gct gag atc cga gat aag aac ttc aac       1028
Asn Ser Ala Glu Glu Leu Tyr Ala Glu Ile Arg Asp Lys Asn Phe Asn           
290                 295                 300                 305           

gca gtt ggc tct gtg ctc agc aag aaa gca aag atc atc tct gca gca       1076
Ala Val Gly Ser Val Leu Ser Lys Lys Ala Lys Ile Ile Ser Ala Ala           
                310                 315                 320               

ttc gag gaa aga cac aat gct aag acc gtg ggg gag atc aag cag ttt       1124
Phe Glu Glu Arg His Asn Ala Lys Thr Val Gly Glu Ile Lys Gln Phe           
            325                 330                 335                   

gtt tcc cag ttg ccc cac atg cag gca gca agg ggc tcg ctt gca aac       1172
Val Ser Gln Leu Pro His Met Gln Ala Ala Arg Gly Ser Leu Ala Asn           
        340                 345                 350                       

cat acc tca att gca gaa ttg atc aaa gat gtc act act tct gaa gac       1220
His Thr Ser Ile Ala Glu Leu Ile Lys Asp Val Thr Thr Ser Glu Asp           
    355                 360                 365                           

ttt ttt gat aaa tta acc gtg gaa cag gag ttt atg tct gga ata gac       1268
Phe Phe Asp Lys Leu Thr Val Glu Gln Glu Phe Met Ser Gly Ile Asp           
370                 375                 380                 385           

act gat aag gtc aac aat tac att gag gat tgt atc gcc caa aag cac       1316
Thr Asp Lys Val Asn Asn Tyr Ile Glu Asp Cys Ile Ala Gln Lys His           
                390                 395                 400               

tcg ttg atc aag gtg tta aga cta gtt tgc ctc caa tcc gtg tgt aat       1364
Ser Leu Ile Lys Val Leu Arg Leu Val Cys Leu Gln Ser Val Cys Asn           
            405                 410                 415                   

agt ggg ctc aaa caa aaa gtt ttg gat tat tac aaa aga gag att ctc       1412
Ser Gly Leu Lys Gln Lys Val Leu Asp Tyr Tyr Lys Arg Glu Ile Leu           
        420                 425                 430                       

cag aca tac ggc tat gag cac ata ttg acc tta cac aac ctg gag aag       1460
Gln Thr Tyr Gly Tyr Glu His Ile Leu Thr Leu His Asn Leu Glu Lys           
    435                 440                 445                           

gcc ggc ctg ctg aaa ccg cag acg ggg ggc aga aac aat tac cca act       1508
Ala Gly Leu Leu Lys Pro Gln Thr Gly Gly Arg Asn Asn Tyr Pro Thr           
450                 455                 460                 465           

ata cgg aaa aca tta cgc ctc tgg atg gat gat gtt aat gag caa aac       1556
Ile Arg Lys Thr Leu Arg Leu Trp Met Asp Asp Val Asn Glu Gln Asn           
                470                 475                 480               

ccc acg gac ata tcg tat gtg tac agt ggg tat gcc ccg ctc agt gtg       1604
Pro Thr Asp Ile Ser Tyr Val Tyr Ser Gly Tyr Ala Pro Leu Ser Val           
            485                 490                 495                   

cgg ctg gcc cag ctg ctt tcc cgg cct ggc tgg cgg agc atc gag gag       1652
Arg Leu Ala Gln Leu Leu Ser Arg Pro Gly Trp Arg Ser Ile Glu Glu           
        500                 505                 510                       

gtc ctc cgc atc ctc cca ggg ccc cac ttt gag gag cgg cag cca ctg       1700
Val Leu Arg Ile Leu Pro Gly Pro His Phe Glu Glu Arg Gln Pro Leu           
    515                 520                 525                           

ccc aca gga ctg cag aag aaa cgt caa ccg gga gaa aac cga gtg act       1748
Pro Thr Gly Leu Gln Lys Lys Arg Gln Pro Gly Glu Asn Arg Val Thr           
530                 535                 540                 545           

ctg ata ttt ttc ctt ggg ggc gta acc ttc gct gaa att gct gcc ctg       1796
Leu Ile Phe Phe Leu Gly Gly Val Thr Phe Ala Glu Ile Ala Ala Leu           
                550                 555                 560               

cga ttt ctc tcc cag ttg gaa gat gga ggt aca gaa tat gtc att gcc       1844
Arg Phe Leu Ser Gln Leu Glu Asp Gly Gly Thr Glu Tyr Val Ile Ala           
            565                 570                 575                   

acc act aaa cta atg aat gga acc agt tgg ata gag gct ctg atg gaa       1892
Thr Thr Lys Leu Met Asn Gly Thr Ser Trp Ile Glu Ala Leu Met Glu           
        580                 585                 590                       

aaa cct ttc tag gatgttcaga ggagacttaa caagtgtact gcagaataaa           1944
Lys Pro Phe                                                               
    595                                                                   

ctacctcttt gaagaaattg ctgaaaggaa gtaaaacccc atagaagaaa catgggaata     2004

cagaatatat tctggggtca gcttcttaaa ttatactact gtttactgct ttctccgtct     2064

cttttgtatt cccttttttt ttttcctttg agacggagtc ttgctctgtc acccagacta     2124

gagtgcagtg gcacggtctc acctcactgc aacctccacc tcctaggttc aagcaattct     2184

cctgcctcag cctcctgagt agctgggact acaggcatgc accaccacac ccggctaatt     2244

tttgtatttt tagtagccat ggtgtttcac catgttggcc aggctggtct caaactcctg     2304

acctcaggtg atccacctgc ctcggcctcc cacagtgctg ggattacagg cctgagccac     2364

cgtgcctggc ccctaatctg ctgaagaaag aagaatagaa gaaaatcaac ctgagtaaaa     2424

gcagcactgg ttttgagttt tctaagctca gggtcttcat tagagacctc tggaaataca     2484

ttaaggatgg tgggggtaga taatccattc agccagacaa acggggccag ctcttaaaat     2544

aagaaagctg agactgagga ggtgaaactg aaaataaaaa gagaaagttc atcctctaaa     2604

aaaaaaaaaa aaaaaaaaaa aaaa                                            2628


<210>  750
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  750

Met Ala Ala His Leu Ser Tyr Gly Arg Val Asn Leu Asn Val Leu Arg 
1               5                   10                  15      


Glu Ala Val Arg Arg Glu Leu Arg Glu Phe Leu Asp Lys Cys Ala Gly 
            20                  25                  30          


Ser Lys Ala Ile Val Trp Asp Glu Tyr Leu Thr Gly Pro Phe Gly Leu 
        35                  40                  45              


Ile Ala Gln Tyr Ser Leu Leu Lys Glu His Glu Val Glu Lys Met Phe 
    50                  55                  60                  


Thr Leu Lys Gly Asn Arg Leu Pro Ala Ala Asp Val Lys Asn Ile Ile 
65                  70                  75                  80  


Phe Phe Val Arg Pro Arg Leu Glu Leu Met Asp Ile Ile Ala Glu Asn 
                85                  90                  95      


Val Leu Ser Glu Asp Arg Arg Gly Pro Thr Arg Asp Phe His Ile Leu 
            100                 105                 110         


Phe Val Pro Arg Arg Ser Leu Leu Cys Glu Gln Arg Leu Lys Asp Leu 
        115                 120                 125             


Gly Val Leu Gly Ser Phe Ile His Arg Glu Glu Tyr Ser Leu Asp Leu 
    130                 135                 140                 


Ile Pro Phe Asp Gly Asp Leu Leu Ser Met Glu Ser Glu Gly Ala Phe 
145                 150                 155                 160 


Lys Glu Cys Tyr Leu Glu Gly Asp Gln Thr Ser Leu Tyr His Ala Ala 
                165                 170                 175     


Lys Gly Leu Met Thr Leu Gln Ala Leu Tyr Gly Thr Ile Pro Gln Ile 
            180                 185                 190         


Phe Gly Lys Gly Glu Cys Ala Arg Gln Val Ala Asn Met Met Ile Arg 
        195                 200                 205             


Met Lys Arg Glu Phe Thr Gly Ser Gln Asn Ser Ile Phe Pro Val Phe 
    210                 215                 220                 


Asp Asn Leu Leu Leu Leu Asp Arg Asn Val Asp Leu Leu Thr Pro Leu 
225                 230                 235                 240 


Ala Thr Gln Leu Thr Tyr Glu Gly Leu Ile Asp Glu Ile Tyr Gly Ile 
                245                 250                 255     


Gln Asn Ser Tyr Val Lys Leu Pro Pro Glu Lys Phe Ala Pro Lys Lys 
            260                 265                 270         


Gln Gly Asp Gly Gly Lys Asp Leu Pro Thr Glu Ala Lys Lys Leu Gln 
        275                 280                 285             


Leu Asn Ser Ala Glu Glu Leu Tyr Ala Glu Ile Arg Asp Lys Asn Phe 
    290                 295                 300                 


Asn Ala Val Gly Ser Val Leu Ser Lys Lys Ala Lys Ile Ile Ser Ala 
305                 310                 315                 320 


Ala Phe Glu Glu Arg His Asn Ala Lys Thr Val Gly Glu Ile Lys Gln 
                325                 330                 335     


Phe Val Ser Gln Leu Pro His Met Gln Ala Ala Arg Gly Ser Leu Ala 
            340                 345                 350         


Asn His Thr Ser Ile Ala Glu Leu Ile Lys Asp Val Thr Thr Ser Glu 
        355                 360                 365             


Asp Phe Phe Asp Lys Leu Thr Val Glu Gln Glu Phe Met Ser Gly Ile 
    370                 375                 380                 


Asp Thr Asp Lys Val Asn Asn Tyr Ile Glu Asp Cys Ile Ala Gln Lys 
385                 390                 395                 400 


His Ser Leu Ile Lys Val Leu Arg Leu Val Cys Leu Gln Ser Val Cys 
                405                 410                 415     


Asn Ser Gly Leu Lys Gln Lys Val Leu Asp Tyr Tyr Lys Arg Glu Ile 
            420                 425                 430         


Leu Gln Thr Tyr Gly Tyr Glu His Ile Leu Thr Leu His Asn Leu Glu 
        435                 440                 445             


Lys Ala Gly Leu Leu Lys Pro Gln Thr Gly Gly Arg Asn Asn Tyr Pro 
    450                 455                 460                 


Thr Ile Arg Lys Thr Leu Arg Leu Trp Met Asp Asp Val Asn Glu Gln 
465                 470                 475                 480 


Asn Pro Thr Asp Ile Ser Tyr Val Tyr Ser Gly Tyr Ala Pro Leu Ser 
                485                 490                 495     


Val Arg Leu Ala Gln Leu Leu Ser Arg Pro Gly Trp Arg Ser Ile Glu 
            500                 505                 510         


Glu Val Leu Arg Ile Leu Pro Gly Pro His Phe Glu Glu Arg Gln Pro 
        515                 520                 525             


Leu Pro Thr Gly Leu Gln Lys Lys Arg Gln Pro Gly Glu Asn Arg Val 
    530                 535                 540                 


Thr Leu Ile Phe Phe Leu Gly Gly Val Thr Phe Ala Glu Ile Ala Ala 
545                 550                 555                 560 


Leu Arg Phe Leu Ser Gln Leu Glu Asp Gly Gly Thr Glu Tyr Val Ile 
                565                 570                 575     


Ala Thr Thr Lys Leu Met Asn Gly Thr Ser Trp Ile Glu Ala Leu Met 
            580                 585                 590         


Glu Lys Pro Phe 
        595     


<210>  751
<211>  4360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (332)..(1288)

<400>  751
gcggccgcgg cagggctggg cctgcgacta cccgaggagg ctgacctcca gcccgggcgc       60

ccggttcagc gccgccccgg ccggcgccgg tgcctgccag gcactcaggg aggcgggggc      120

gcagtggagg aggcggcgcc atcgcgaagc gagcgcctcg cccgcactca gccttgccac      180

cccgcccgca gtccaggctg gactgggcgg catttgccga ggctcctcgg ccaggccccg      240

tccgcccgag ccgcgctgag acccgggcag cggccgcgtg gagaggaggt ggcagcggcc      300

cgggaggccg gagccaagcc agcgacccac c atg gag acc cgc tac aac ctg         352
                                   Met Glu Thr Arg Tyr Asn Leu            
                                   1               5                      

aag agt ccg gct gtt aaa cgt tta atg aaa gaa gcg gca gaa ttg aaa        400
Lys Ser Pro Ala Val Lys Arg Leu Met Lys Glu Ala Ala Glu Leu Lys           
        10                  15                  20                        

gat cca aca gat cat tac cat gcg cag cct tta gag gat aac ctt ttt        448
Asp Pro Thr Asp His Tyr His Ala Gln Pro Leu Glu Asp Asn Leu Phe           
    25                  30                  35                            

gaa tgg cac ttc acg gtt aga ggg ccc cca gac tcc gat ttt gat gga        496
Glu Trp His Phe Thr Val Arg Gly Pro Pro Asp Ser Asp Phe Asp Gly           
40                  45                  50                  55            

gga gtt tat cac ggg cgg ata gta ctg cca cca gag tat ccc atg aaa        544
Gly Val Tyr His Gly Arg Ile Val Leu Pro Pro Glu Tyr Pro Met Lys           
                60                  65                  70                

cca cca agc att att ctc cta acg gct aat ggt cga ttt gaa gtg ggc        592
Pro Pro Ser Ile Ile Leu Leu Thr Ala Asn Gly Arg Phe Glu Val Gly           
            75                  80                  85                    

aag aaa atc tgt ttg agc atc tca ggc cat cat cct gaa act tgg cag        640
Lys Lys Ile Cys Leu Ser Ile Ser Gly His His Pro Glu Thr Trp Gln           
        90                  95                  100                       

cct tcg tgg agt ata agg aca gca tta tta gcc atc att ggg ttt atg        688
Pro Ser Trp Ser Ile Arg Thr Ala Leu Leu Ala Ile Ile Gly Phe Met           
    105                 110                 115                           

cca aca aaa gga gag gga gcc ata ggt tct cta gat tac act cct gag        736
Pro Thr Lys Gly Glu Gly Ala Ile Gly Ser Leu Asp Tyr Thr Pro Glu           
120                 125                 130                 135           

gaa aga aga gca ctt gcc aaa aaa tca caa gat ttc tgt tgt gaa gga        784
Glu Arg Arg Ala Leu Ala Lys Lys Ser Gln Asp Phe Cys Cys Glu Gly           
                140                 145                 150               

tgt ggc tct gcc atg aag gat gtc ctg ttg cct tta aaa tct gga agc        832
Cys Gly Ser Ala Met Lys Asp Val Leu Leu Pro Leu Lys Ser Gly Ser           
            155                 160                 165                   

gat tca agc caa gct gac caa gaa gcc aaa gaa ctg gct agg caa ata        880
Asp Ser Ser Gln Ala Asp Gln Glu Ala Lys Glu Leu Ala Arg Gln Ile           
        170                 175                 180                       

agc ttt aag gca gaa gtc aat tca tct gga aag act atc tct gag tca        928
Ser Phe Lys Ala Glu Val Asn Ser Ser Gly Lys Thr Ile Ser Glu Ser           
    185                 190                 195                           

gac tta aac cac tct ttt tca cta act gat tta caa gat gat ata cct        976
Asp Leu Asn His Ser Phe Ser Leu Thr Asp Leu Gln Asp Asp Ile Pro           
200                 205                 210                 215           

aca aca ttc cag ggt gct acg gcc agt aca tcg tac gga ctc cag aat       1024
Thr Thr Phe Gln Gly Ala Thr Ala Ser Thr Ser Tyr Gly Leu Gln Asn           
                220                 225                 230               

tcc tca gca gca tcc ttt cat caa cct acc caa cct gta gct aag aat       1072
Ser Ser Ala Ala Ser Phe His Gln Pro Thr Gln Pro Val Ala Lys Asn           
            235                 240                 245                   

acc tcc atg agc cct cga cag cgc cgg gcc cag cag cag agt cag aga       1120
Thr Ser Met Ser Pro Arg Gln Arg Arg Ala Gln Gln Gln Ser Gln Arg           
        250                 255                 260                       

agg ttg tct act tca cca gat gta atc cag ggc cac cag cca aga gac       1168
Arg Leu Ser Thr Ser Pro Asp Val Ile Gln Gly His Gln Pro Arg Asp           
    265                 270                 275                           

aac cac act gat cat ggt ggg tca gct gta ctg att gtc atc ctg act       1216
Asn His Thr Asp His Gly Gly Ser Ala Val Leu Ile Val Ile Leu Thr           
280                 285                 290                 295           

ttg gca ttg gca gct ctt ata ttc cga cga ata tat ctg gca aac gaa       1264
Leu Ala Leu Ala Ala Leu Ile Phe Arg Arg Ile Tyr Leu Ala Asn Glu           
                300                 305                 310               

tac ata ttt gac ttt gag tta taa tatggttttg tgacttatga gctgtgactc      1318
Tyr Ile Phe Asp Phe Glu Leu                                               
            315                                                           

aactgcttca ttaaacattc tgcattgggt ataatctaag aattgtttac aaaaagatta     1378

ttttgtattt acccttcatt cctttttttg atccttgtaa gtttagtata aatatatcta     1438

gacattcaga ctgtgtctag cagttacgtc ctgcttaaag ggactagaag tcaaagttcc     1498

ttgtctcact atttgatctg ctttgcaggg aaataacttg ttttttctca tgtttcatct     1558

tctttttatg taaatttgta atactttcct atattgccct ttgaaatttt tggataaaag     1618

atgatgtttt aagttccaat gagtattact agttactcaa taccacttat tgagtactct     1678

gtttctacgt atgtagaatg tatagggata gaagagttga aaagggaaag caaaactcct     1738

caagtagctt ccttaaaatg tcattcatag gagatgtact ggaattgctc attctgtgac     1798

tttatttgtg tcctaaacat tcttcagtga aaataatttt atttcagtca aacatttatg     1858

aggaaatgag atcacatctt tgtcactgga tgctacttga agagggagta ctttgtaacc     1918

actttgatat gctgttatca ccaccccctg ccctctgctg ccataatcac acaaatttaa     1978

aaagaaagaa aacagtcttc catagatttt taaggaagaa agggcccaag ccaggagatc     2038

gcttggtttt cttccagaag ttaaatgggg ggatctgaag atttgaatgt ttggtctgct     2098

ttgaaatgta tgtcttttgg gatgtattat atgcctagct ttataatcag tataaatttt     2158

aattattcca ggaatatgca taatattgaa atatttcatg tcctatttta atagaaaacc     2218

tcagggccca agtaacagtg atagaagtta gaaaaacctt tacttagaat tgtccaccta     2278

gtcagagccc aagaaagaat tttcagtgga aaaatcaata tataacttag tgctagctag     2338

cgccacagac tctagtagat aatattatca tcataatggc tggtgaaacc atataatcac     2398

agaaaaacat tgccttcagc atgttcagtt cgcagcactg agggcactct tgagggtgtt     2458

gttaatgaag atttaatttt taaatacagg tggttccaag ctttcaaata ggttatgctc     2518

caaaagtgtt atttgtaagt taattttttt acaagtcaaa caatgttgga agtggtattt     2578

aggttctaga tcggtccacg aaagttagcc catatgtata tcttgaatag tataggggag     2638

ggtattcata aagtccttat gtggttttaa ctaagtgaaa ttatggacaa gagaaataat     2698

tgtaaaatcg tcttaaagga aaatttaatt tttactcctg tttatgggac attcgttcta     2758

ttaactgtca gacacaattt ctgttttcat ctgagagcca gttttccttt atttctacat     2818

ctaaaataag aacatattgt acactattat ataatacaga attgtcttaa actttaataa     2878

attcgcattt taaaggtgtt tacagattat tttttatatc tgtagctgaa tttgttaaag     2938

tctaaaaagc tcaaggactt tatgaagatc tcattatatg aggaaaatca taggttacca     2998

ttttataact ctattgccat aagaaaatac actctaaaat cttgatttga aacatattag     3058

aaaccttgat tcagtgctca gtggtctcct agtaagaagt caccgacggt agcgtcatat     3118

gagaagaaag aaatccccac cacctcaacc tctgctgaga ttgtgtgcta ggaacagcct     3178

tccctccgtt tcccctcagt caaacttgag ccagcctctg gatcgatgtg atcttattgc     3238

atgtttccat ggggtgtacc tatactttaa gccaatcctg ctgcattcac tgctaagtta     3298

aataaaaagc caagaagatt ttgcactgtg cagatccttt gctatctgac ttgcatctct     3358

tcccccacct gtcagctagc cacctgcttg tttgtgttgg gatatttttt agcacctgaa     3418

gcaccatctg aaaggggcac cattttcttc ttccctttga tctcacatat gctccctaaa     3478

aatccttaag ttgtcaatct gatccccagt gtgaggttaa tgagcaaaat tggtctttgg     3538

ggcccttttt gtccaagccc cactgaaagg cctcttcaga aaactattat ctttaaagcc     3598

ctactttaac tccttaattc cagcatacag ctaaaactgg atgtatattc tggcaagtaa     3658

aggctgagga ctcctcttta atcctcagat ctagataact catgacattt tatttgacca     3718

acatagcaca tgatgagata tcaaggtaat taaaatagca tgcttgaaaa aaaaatacgt     3778

aatctgtttc acctgtaact gtttaagcca ataaactttt caaaatttat gtaatgtggg     3838

gcttttatgt agcactttac gttttcatgc tgcttattgt tttattctac tgaaaaaaat     3898

gaatttcaag attctcaact tttttaattt caaaaattgt ttattgtttt gactatagga     3958

atacaaaatt tcctattttg ggagaataag aactcttttt gtcatttttg gctatgaata     4018

aactttctgg tcttttgaga ccacccattt ttatagatca gaatcagaaa acaggtaaac     4078

ctcactcaca catttggact catttgaaca aaaatctagg ccaaaatact gaaaagccta     4138

tgtgtttttt taattggaag tatatgtaag gttaatgcat ttagtgaacg tgactaacaa     4198

agactaatgt gcacattaac agatgtactt tttaaggttt tatgggaggc tgtgcattgc     4258

tcaaaagctg ttgggaacgc cttctgaaca gttgccttca gaactagttt gagctgctca     4318

ataaaaccag tgactttact cataaaaaaa aaaaaaaaaa aa                        4360


<210>  752
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  752

Met Glu Thr Arg Tyr Asn Leu Lys Ser Pro Ala Val Lys Arg Leu Met 
1               5                   10                  15      


Lys Glu Ala Ala Glu Leu Lys Asp Pro Thr Asp His Tyr His Ala Gln 
            20                  25                  30          


Pro Leu Glu Asp Asn Leu Phe Glu Trp His Phe Thr Val Arg Gly Pro 
        35                  40                  45              


Pro Asp Ser Asp Phe Asp Gly Gly Val Tyr His Gly Arg Ile Val Leu 
    50                  55                  60                  


Pro Pro Glu Tyr Pro Met Lys Pro Pro Ser Ile Ile Leu Leu Thr Ala 
65                  70                  75                  80  


Asn Gly Arg Phe Glu Val Gly Lys Lys Ile Cys Leu Ser Ile Ser Gly 
                85                  90                  95      


His His Pro Glu Thr Trp Gln Pro Ser Trp Ser Ile Arg Thr Ala Leu 
            100                 105                 110         


Leu Ala Ile Ile Gly Phe Met Pro Thr Lys Gly Glu Gly Ala Ile Gly 
        115                 120                 125             


Ser Leu Asp Tyr Thr Pro Glu Glu Arg Arg Ala Leu Ala Lys Lys Ser 
    130                 135                 140                 


Gln Asp Phe Cys Cys Glu Gly Cys Gly Ser Ala Met Lys Asp Val Leu 
145                 150                 155                 160 


Leu Pro Leu Lys Ser Gly Ser Asp Ser Ser Gln Ala Asp Gln Glu Ala 
                165                 170                 175     


Lys Glu Leu Ala Arg Gln Ile Ser Phe Lys Ala Glu Val Asn Ser Ser 
            180                 185                 190         


Gly Lys Thr Ile Ser Glu Ser Asp Leu Asn His Ser Phe Ser Leu Thr 
        195                 200                 205             


Asp Leu Gln Asp Asp Ile Pro Thr Thr Phe Gln Gly Ala Thr Ala Ser 
    210                 215                 220                 


Thr Ser Tyr Gly Leu Gln Asn Ser Ser Ala Ala Ser Phe His Gln Pro 
225                 230                 235                 240 


Thr Gln Pro Val Ala Lys Asn Thr Ser Met Ser Pro Arg Gln Arg Arg 
                245                 250                 255     


Ala Gln Gln Gln Ser Gln Arg Arg Leu Ser Thr Ser Pro Asp Val Ile 
            260                 265                 270         


Gln Gly His Gln Pro Arg Asp Asn His Thr Asp His Gly Gly Ser Ala 
        275                 280                 285             


Val Leu Ile Val Ile Leu Thr Leu Ala Leu Ala Ala Leu Ile Phe Arg 
    290                 295                 300                 


Arg Ile Tyr Leu Ala Asn Glu Tyr Ile Phe Asp Phe Glu Leu 
305                 310                 315             


<210>  753
<211>  2634
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (142)..(789)

<400>  753
acaggcacag gtgaggaact caactcaaac tcctctctct gggaaaacgc ggtgcttgct       60

cctcccggag tggccttggc agggtgttgg agccctcggt ctgccccgtc cggtctctgg      120

ggccaaggct gggtttccct c atg tat ggc aag agc tct act cgt gcg gtg        171
                        Met Tyr Gly Lys Ser Ser Thr Arg Ala Val           
                        1               5                   10            

ctt ctt ctc ctt ggc ata cag ctc aca gct ctt tgg cct ata gca gct        219
Leu Leu Leu Leu Gly Ile Gln Leu Thr Ala Leu Trp Pro Ile Ala Ala           
                15                  20                  25                

gtg gaa att tat acc tcc cgg gtg ctg gag gct gtt aat ggg aca gat        267
Val Glu Ile Tyr Thr Ser Arg Val Leu Glu Ala Val Asn Gly Thr Asp           
            30                  35                  40                    

gct cgg tta aaa tgc act ttc tcc agc ttt gcc cct gtg ggt gat gct        315
Ala Arg Leu Lys Cys Thr Phe Ser Ser Phe Ala Pro Val Gly Asp Ala           
        45                  50                  55                        

cta aca gtg acc tgg aat ttt cgt cct cta gac ggg gga cct gag cag        363
Leu Thr Val Thr Trp Asn Phe Arg Pro Leu Asp Gly Gly Pro Glu Gln           
    60                  65                  70                            

ttt gta ttc tac tac cac ata gat ccc ttc caa ccc atg agt ggg cgg        411
Phe Val Phe Tyr Tyr His Ile Asp Pro Phe Gln Pro Met Ser Gly Arg           
75                  80                  85                  90            

ttt aag gac cgg gtg tct tgg gat ggg aat cct gag cgg tac gat gcc        459
Phe Lys Asp Arg Val Ser Trp Asp Gly Asn Pro Glu Arg Tyr Asp Ala           
                95                  100                 105               

tcc atc ctt ctc tgg aaa ctg cag ttc gac gac aat ggg aca tac acc        507
Ser Ile Leu Leu Trp Lys Leu Gln Phe Asp Asp Asn Gly Thr Tyr Thr           
            110                 115                 120                   

tgc cag gtg aag aac cca cct gat gtt gat ggg gtg ata ggg gag atc        555
Cys Gln Val Lys Asn Pro Pro Asp Val Asp Gly Val Ile Gly Glu Ile           
        125                 130                 135                       

cgg ctc agc gtc gtg cac act gta cgc ttc tct gag atc cac ttc ctg        603
Arg Leu Ser Val Val His Thr Val Arg Phe Ser Glu Ile His Phe Leu           
    140                 145                 150                           

gct ctg gcc att ggc tct gcc tgt gca ctg atg atc ata ata gta att        651
Ala Leu Ala Ile Gly Ser Ala Cys Ala Leu Met Ile Ile Ile Val Ile           
155                 160                 165                 170           

gta gtg gtc ctc ttc cag cat tac cgg aaa aag cga tgg gcc gaa aga        699
Val Val Val Leu Phe Gln His Tyr Arg Lys Lys Arg Trp Ala Glu Arg           
                175                 180                 185               

gct cat aaa gtg gtg gag ata aaa tca aaa gaa gag gaa agg ctc aac        747
Ala His Lys Val Val Glu Ile Lys Ser Lys Glu Glu Glu Arg Leu Asn           
            190                 195                 200                   

caa gag aaa aag gtc tct gtt tat tta gaa gac aca gac taa                789
Gln Glu Lys Lys Val Ser Val Tyr Leu Glu Asp Thr Asp                       
        205                 210                 215                       

caattttaga tggaagctga gatgatttcc aagaacaaga accctagtat ttcttgaagt      849

taatggaaac ttttctttgg cttttccagt tgtgacccgt tttccaacca gttctgcagc      909

atattagatt ctagacaagc aacacccctc tggagccagc acagtgctcc tccatatcac      969

cagtcataca cagcctcatt attaaggtct tatttaattt cagagtgtaa attttttcaa     1029

gtgctcatta ggttttataa acaagaagct acatttttgc ccttaagaca ctacttacag     1089

tgttatgact tgtatacaca tatattggta tcaaaaggga taaaagccaa tttgtctgtt     1149

acatttcctt tcacgtattt cttttagcag cacttctgct actaaagtta atgtgtttac     1209

tctctttcct tcccacattc tcaattaaaa ggtgagctaa gcctcctcgg tgtttctgat     1269

taacagtaaa tcctaaattc aaactgttaa atgacatttt tatttttatg tctctcctta     1329

actatgagac acatcttgtt ttactgaatt tctttcaata ttccaggtga tagatttttg     1389

ttgttttgtt aattaatcca agatttacaa tagcacaacg ctaaatcaca cagtaactac     1449

aaaaggttac atagatatga aaagattggc agaggccatt gcaggatgaa tcacttgtca     1509

cttttcttct gtgctgggaa aaataatcaa caatgtgggt ctttcatgag cagtgacgga     1569

tagtttagct tactatgttt cccccccaat tcaatgatct ataacaacag agcaaagtct     1629

atgctcattt gcagactgga atcattaagt aatttaataa aaaaattgtg aaacagcata     1689

ttacaagttt gaaaattcag ggctggtgaa aaaaatcaac tctaaatgat gataattttg     1749

tacagtttta tataaaactc tgagaactag aagaaattat taactttttt tcttttttaa     1809

ttctaattca cttgtttatt ttgggggagg aagactttgg tatggagcaa agaaatacca     1869

aaactacttt aaatggaata aaaccaactt tattcttttt ttcccccata ctggtagata     1929

aagcaaactt tataagtggg ctattgaaag aaaagttaca agcttaagat acagaagcat     1989

ttgttcaaag gatagaaagc atctaaaagt ttaggctcaa gatcaatctt tacagattga     2049

tattttcagt ttttaatcga ctggactgca gatgtttttt cttttaacaa actggaattt     2109

tcaaacagat tatctgtatt taaatgtata gaccttgata tttttccaat actatttttt     2169

aaaaaattgt atgatttaca tatgaacctc agttctgaaa ttcattacat atctgtctca     2229

ttctgccttt tatactgtct aaaaaagcaa agttttaaag tgcaatttta aaactgtaaa     2289

ttacatctga aggctatata tcctttaatc acattttata ttttttcttc acaattctaa     2349

cctttgaaaa tattataact ggatatttct tcaaacagat gtcctggatg atggtccata     2409

agaataatga agaagtagtt aaaaatgtat ggacagtttt tccggcaaaa tttgtagctt     2469

atgtcttggc taaatagtca aggggtaata tgggcctgtt gtttagtgtc tccttcctaa     2529

agagcacttt tgtattgtaa tttatttttt attatgcttt aaacactatg taaataaacc     2589

tttagtaata aagaattatc agttataaaa aaaaaaaaaa aaaaa                     2634


<210>  754
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  754

Met Tyr Gly Lys Ser Ser Thr Arg Ala Val Leu Leu Leu Leu Gly Ile 
1               5                   10                  15      


Gln Leu Thr Ala Leu Trp Pro Ile Ala Ala Val Glu Ile Tyr Thr Ser 
            20                  25                  30          


Arg Val Leu Glu Ala Val Asn Gly Thr Asp Ala Arg Leu Lys Cys Thr 
        35                  40                  45              


Phe Ser Ser Phe Ala Pro Val Gly Asp Ala Leu Thr Val Thr Trp Asn 
    50                  55                  60                  


Phe Arg Pro Leu Asp Gly Gly Pro Glu Gln Phe Val Phe Tyr Tyr His 
65                  70                  75                  80  


Ile Asp Pro Phe Gln Pro Met Ser Gly Arg Phe Lys Asp Arg Val Ser 
                85                  90                  95      


Trp Asp Gly Asn Pro Glu Arg Tyr Asp Ala Ser Ile Leu Leu Trp Lys 
            100                 105                 110         


Leu Gln Phe Asp Asp Asn Gly Thr Tyr Thr Cys Gln Val Lys Asn Pro 
        115                 120                 125             


Pro Asp Val Asp Gly Val Ile Gly Glu Ile Arg Leu Ser Val Val His 
    130                 135                 140                 


Thr Val Arg Phe Ser Glu Ile His Phe Leu Ala Leu Ala Ile Gly Ser 
145                 150                 155                 160 


Ala Cys Ala Leu Met Ile Ile Ile Val Ile Val Val Val Leu Phe Gln 
                165                 170                 175     


His Tyr Arg Lys Lys Arg Trp Ala Glu Arg Ala His Lys Val Val Glu 
            180                 185                 190         


Ile Lys Ser Lys Glu Glu Glu Arg Leu Asn Gln Glu Lys Lys Val Ser 
        195                 200                 205             


Val Tyr Leu Glu Asp Thr Asp 
    210                 215 


<210>  755
<211>  684
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (139)..(435)

<400>  755
cattcccagc ctcacatcac tcacaccttg catttcaccc ctgcatccca gtcgccctgc       60

agcctcacac agatcctgca cacacccaga cagctggcgc tcacacattc accgttggcc      120

tgcctctgtt caccctcc atg gcc ctg cta ctg gcc ctc agc ctg ctg gtt        171
                    Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val           
                    1               5                   10                

ctc tgg act tcc cca gcc cca act ctg agt ggc acc aat gat gct gaa        219
Leu Trp Thr Ser Pro Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu           
            15                  20                  25                    

gac tgc tgc ctg tct gtg acc cag aaa ccc atc cct ggg tac atc gtg        267
Asp Cys Cys Leu Ser Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val           
        30                  35                  40                        

agg aac ttc cac tac ctt ctc atc aag gat ggc tgc agg gtg cct gct        315
Arg Asn Phe His Tyr Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala           
    45                  50                  55                            

gta gtg ttc acc aca ctg agg ggc cgc cag ctc tgt gca ccc cca gac        363
Val Val Phe Thr Thr Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp           
60                  65                  70                  75            

cag ccc tgg gta gaa cgc atc atc cag aga ctg cag agg acc tca gcc        411
Gln Pro Trp Val Glu Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala           
                80                  85                  90                

aag atg aag cgc cgc agc agt taa cctatgaccg tgcagaggga gcccggagtc       465
Lys Met Lys Arg Arg Ser Ser                                               
            95                                                            

cgagtcaagc attgtgaatt attacctaac ctggggaacc gaggaccaga aggaaggacc      525

aggcttccag ctcctctgca ccagacctga ccagccagga cagggcctgg ggtgtgtgtg      585

agtgtgagtg tgagcgagag ggtgagtgtg gtcagagtaa agctgctcca cccccagatt      645

gcaatgctac caataaagcc gcctggtgtt tacaactaa                             684


<210>  756
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  756

Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Thr Ser Pro 
1               5                   10                  15      


Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg 
                85                  90                  95      


Ser Ser 
        


<210>  757
<211>  2518
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (39)..(2225)

<400>  757
gtgagaggtc agcagagggg cggtctgcgg ggacaaca atg gcg ggg ttc tgg gtc       56
                                          Met Ala Gly Phe Trp Val         
                                          1               5               

ggg aca gca ccg ctg gtc gct gcc gga cgg cgt ggg cgg tgg ccg ccg        104
Gly Thr Ala Pro Leu Val Ala Ala Gly Arg Arg Gly Arg Trp Pro Pro           
            10                  15                  20                    

cag cag ctg atg ctg agc gcg gcg ctg cgg acc ctg aag cat gtt ctg        152
Gln Gln Leu Met Leu Ser Ala Ala Leu Arg Thr Leu Lys His Val Leu           
        25                  30                  35                        

tac tat tca aga cag tgc tta atg gtg tcc cgt aat ctt ggt tca gtg        200
Tyr Tyr Ser Arg Gln Cys Leu Met Val Ser Arg Asn Leu Gly Ser Val           
    40                  45                  50                            

gga tat gat cct aat gaa aaa act ttt gat aaa att ctt gtt gct aat        248
Gly Tyr Asp Pro Asn Glu Lys Thr Phe Asp Lys Ile Leu Val Ala Asn           
55                  60                  65                  70            

aga gga gaa att gca tgt cgg gtt att aga act tgc aag aag atg ggc        296
Arg Gly Glu Ile Ala Cys Arg Val Ile Arg Thr Cys Lys Lys Met Gly           
                75                  80                  85                

att aag aca gtt gcc atc cac agt gat gtt gat gct agt tct gtt cat        344
Ile Lys Thr Val Ala Ile His Ser Asp Val Asp Ala Ser Ser Val His           
            90                  95                  100                   

gtg aaa atg gcg gat gag gct gtc tgt gtt ggc cca gct ccc acc agt        392
Val Lys Met Ala Asp Glu Ala Val Cys Val Gly Pro Ala Pro Thr Ser           
        105                 110                 115                       

aaa agc tac ctc aac atg gat gcc atc atg gaa gcc att aag aaa acc        440
Lys Ser Tyr Leu Asn Met Asp Ala Ile Met Glu Ala Ile Lys Lys Thr           
    120                 125                 130                           

agg gcc caa gct gta cat cca ggt tat gga ttc ctt tca gaa aac aaa        488
Arg Ala Gln Ala Val His Pro Gly Tyr Gly Phe Leu Ser Glu Asn Lys           
135                 140                 145                 150           

gaa ttt gcc aga tgt ttg gca gca gaa gat gtc gtt ttc att gga cct        536
Glu Phe Ala Arg Cys Leu Ala Ala Glu Asp Val Val Phe Ile Gly Pro           
                155                 160                 165               

gac aca cat gct att caa gcc atg ggc gac aag att gaa agc aaa tta        584
Asp Thr His Ala Ile Gln Ala Met Gly Asp Lys Ile Glu Ser Lys Leu           
            170                 175                 180                   

tta gct aag aaa gca gag gtt aat aca atc cct ggc ttt gat gga gta        632
Leu Ala Lys Lys Ala Glu Val Asn Thr Ile Pro Gly Phe Asp Gly Val           
        185                 190                 195                       

gtc aag gat gca gaa gaa gct gtc aga att gca agg gaa att ggc tac        680
Val Lys Asp Ala Glu Glu Ala Val Arg Ile Ala Arg Glu Ile Gly Tyr           
    200                 205                 210                           

cct gtc atg atc aag gcc tca gca ggt ggt ggt ggg aaa ggc atg cgc        728
Pro Val Met Ile Lys Ala Ser Ala Gly Gly Gly Gly Lys Gly Met Arg           
215                 220                 225                 230           

att gct tgg gat gat gaa gag acc agg gat ggt ttt aga ttg tca tct        776
Ile Ala Trp Asp Asp Glu Glu Thr Arg Asp Gly Phe Arg Leu Ser Ser           
                235                 240                 245               

caa gaa gct gct tct agt ttt ggc gat gat aga cta cta ata gaa aaa        824
Gln Glu Ala Ala Ser Ser Phe Gly Asp Asp Arg Leu Leu Ile Glu Lys           
            250                 255                 260                   

ttt att gat aat cct cgt cat ata gaa atc cag gtt cta ggt gat aaa        872
Phe Ile Asp Asn Pro Arg His Ile Glu Ile Gln Val Leu Gly Asp Lys           
        265                 270                 275                       

cat ggg aat gct tta tgg ctt aat gaa aga gag tgc tca att cag aga        920
His Gly Asn Ala Leu Trp Leu Asn Glu Arg Glu Cys Ser Ile Gln Arg           
    280                 285                 290                           

aga aat cag aag gtg gtg gag gaa gca cca agc att ttt ttg gat gcg        968
Arg Asn Gln Lys Val Val Glu Glu Ala Pro Ser Ile Phe Leu Asp Ala           
295                 300                 305                 310           

gag act cga aga gcg atg gga gaa caa gct gta gct ctt gcc aga gca       1016
Glu Thr Arg Arg Ala Met Gly Glu Gln Ala Val Ala Leu Ala Arg Ala           
                315                 320                 325               

gta aaa tat tcc tct gct ggg acc gtg gag ttc ctt gtg gac tct aag       1064
Val Lys Tyr Ser Ser Ala Gly Thr Val Glu Phe Leu Val Asp Ser Lys           
            330                 335                 340                   

aag aat ttt tat ttc ttg gaa atg aat aca aga ctc cag gtt gag cat       1112
Lys Asn Phe Tyr Phe Leu Glu Met Asn Thr Arg Leu Gln Val Glu His           
        345                 350                 355                       

cct gtc aca gaa tgc att act ggc ctg gac cta gtc cag gaa atg atc       1160
Pro Val Thr Glu Cys Ile Thr Gly Leu Asp Leu Val Gln Glu Met Ile           
    360                 365                 370                           

cgt gtt gct aag ggc tac cct ctc agg cac aaa caa gct gat att cgc       1208
Arg Val Ala Lys Gly Tyr Pro Leu Arg His Lys Gln Ala Asp Ile Arg           
375                 380                 385                 390           

atc aac ggc tgg gca gtt gaa tgt cgg gtt tat gct gag gac ccc tac       1256
Ile Asn Gly Trp Ala Val Glu Cys Arg Val Tyr Ala Glu Asp Pro Tyr           
                395                 400                 405               

aag tct ttt ggt tta cca tct att ggg aga ttg tct cag tac caa gaa       1304
Lys Ser Phe Gly Leu Pro Ser Ile Gly Arg Leu Ser Gln Tyr Gln Glu           
            410                 415                 420                   

ccg tta cat cta cct ggt gtc cga gtg gac agt ggc atc caa cca gga       1352
Pro Leu His Leu Pro Gly Val Arg Val Asp Ser Gly Ile Gln Pro Gly           
        425                 430                 435                       

agt gat att agc att tat tat gat cct atg att tca aaa cta atc aca       1400
Ser Asp Ile Ser Ile Tyr Tyr Asp Pro Met Ile Ser Lys Leu Ile Thr           
    440                 445                 450                           

tat ggc tct gat aga act gag gca ctg aag aga atg gca gat gca ctg       1448
Tyr Gly Ser Asp Arg Thr Glu Ala Leu Lys Arg Met Ala Asp Ala Leu           
455                 460                 465                 470           

gat aac tat gtt att cga ggt gtt aca cat aat att gca tta ctt cga       1496
Asp Asn Tyr Val Ile Arg Gly Val Thr His Asn Ile Ala Leu Leu Arg           
                475                 480                 485               

gag gtg ata atc aac tca cgc ttt gta aaa gga gac atc agc act aaa       1544
Glu Val Ile Ile Asn Ser Arg Phe Val Lys Gly Asp Ile Ser Thr Lys           
            490                 495                 500                   

ttt ctc tcc gat gtg tat cct gat ggc ttc aaa gga cac atg cta acc       1592
Phe Leu Ser Asp Val Tyr Pro Asp Gly Phe Lys Gly His Met Leu Thr           
        505                 510                 515                       

aag agt gag aag aac cag tta ttg gca ata gca tca tca ttg ttt gtg       1640
Lys Ser Glu Lys Asn Gln Leu Leu Ala Ile Ala Ser Ser Leu Phe Val           
    520                 525                 530                           

gca ttc cag tta aga gca caa cat ttt caa gaa aat tca aga atg cct       1688
Ala Phe Gln Leu Arg Ala Gln His Phe Gln Glu Asn Ser Arg Met Pro           
535                 540                 545                 550           

gtt att aaa cca gac ata gcc aac tgg gag ctc tca gta aaa ttg cat       1736
Val Ile Lys Pro Asp Ile Ala Asn Trp Glu Leu Ser Val Lys Leu His           
                555                 560                 565               

gat aaa gtt cat acc gta gta gca tca aac aat ggg tca gtg ttc tcg       1784
Asp Lys Val His Thr Val Val Ala Ser Asn Asn Gly Ser Val Phe Ser           
            570                 575                 580                   

gtg gaa gtt gat ggg tcg aaa cta aat gtg acc agc acg tgg aac ctg       1832
Val Glu Val Asp Gly Ser Lys Leu Asn Val Thr Ser Thr Trp Asn Leu           
        585                 590                 595                       

gct tcg ccc tta ttg tct gtc agc gtt gat ggc act cag agg act gtc       1880
Ala Ser Pro Leu Leu Ser Val Ser Val Asp Gly Thr Gln Arg Thr Val           
    600                 605                 610                           

cag tgt ctt tct cga gaa gca ggt gga aac atg agc att cag ttt ctt       1928
Gln Cys Leu Ser Arg Glu Ala Gly Gly Asn Met Ser Ile Gln Phe Leu           
615                 620                 625                 630           

ggt aca gtg tac aag gtg aat atc tta acc aga ctt gcc gca gaa ttg       1976
Gly Thr Val Tyr Lys Val Asn Ile Leu Thr Arg Leu Ala Ala Glu Leu           
                635                 640                 645               

aac aaa ttt atg ctg gaa aaa gtg act gag gac aca agc agt gtt ctg       2024
Asn Lys Phe Met Leu Glu Lys Val Thr Glu Asp Thr Ser Ser Val Leu           
            650                 655                 660                   

cgt tcc ccg atg ccc gga gtg gtg gtg gcc gtc tct gtc aag cct gga       2072
Arg Ser Pro Met Pro Gly Val Val Val Ala Val Ser Val Lys Pro Gly           
        665                 670                 675                       

gac gcg gta gca gaa ggt caa gaa att tgt gtg att gaa gcc atg aaa       2120
Asp Ala Val Ala Glu Gly Gln Glu Ile Cys Val Ile Glu Ala Met Lys           
    680                 685                 690                           

atg cag aat agt atg aca gct ggg aaa act ggc acg gtg aaa tct gtg       2168
Met Gln Asn Ser Met Thr Ala Gly Lys Thr Gly Thr Val Lys Ser Val           
695                 700                 705                 710           

cac tgt caa gct gga gac aca gtt gga gaa ggg gat ctg ctc gtg gag       2216
His Cys Gln Ala Gly Asp Thr Val Gly Glu Gly Asp Leu Leu Val Glu           
                715                 720                 725               

ctg gaa tga aggatttata acctttcagt catcacccaa tttaattagc               2265
Leu Glu                                                                   
                                                                          

catttgcatg atgctttcac acacaattga ttcaagcatt atacaggaac acccctgtgc     2325

agctacgttt acgtcgtcat ttattccaca gagtcaagac caatattctg ccaaaaaatc     2385

accaatggaa attttcattg atataaatac ttgtacatat gatttgtact tctgctgtga     2445

gattccctag tgtcaaaatt aaatcaataa aactgagcat ttgtctaaaa aaaaaaaaaa     2505

aaaaaaaaaa aaa                                                        2518


<210>  758
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  758

Met Ala Gly Phe Trp Val Gly Thr Ala Pro Leu Val Ala Ala Gly Arg 
1               5                   10                  15      


Arg Gly Arg Trp Pro Pro Gln Gln Leu Met Leu Ser Ala Ala Leu Arg 
            20                  25                  30          


Thr Leu Lys His Val Leu Tyr Tyr Ser Arg Gln Cys Leu Met Val Ser 
        35                  40                  45              


Arg Asn Leu Gly Ser Val Gly Tyr Asp Pro Asn Glu Lys Thr Phe Asp 
    50                  55                  60                  


Lys Ile Leu Val Ala Asn Arg Gly Glu Ile Ala Cys Arg Val Ile Arg 
65                  70                  75                  80  


Thr Cys Lys Lys Met Gly Ile Lys Thr Val Ala Ile His Ser Asp Val 
                85                  90                  95      


Asp Ala Ser Ser Val His Val Lys Met Ala Asp Glu Ala Val Cys Val 
            100                 105                 110         


Gly Pro Ala Pro Thr Ser Lys Ser Tyr Leu Asn Met Asp Ala Ile Met 
        115                 120                 125             


Glu Ala Ile Lys Lys Thr Arg Ala Gln Ala Val His Pro Gly Tyr Gly 
    130                 135                 140                 


Phe Leu Ser Glu Asn Lys Glu Phe Ala Arg Cys Leu Ala Ala Glu Asp 
145                 150                 155                 160 


Val Val Phe Ile Gly Pro Asp Thr His Ala Ile Gln Ala Met Gly Asp 
                165                 170                 175     


Lys Ile Glu Ser Lys Leu Leu Ala Lys Lys Ala Glu Val Asn Thr Ile 
            180                 185                 190         


Pro Gly Phe Asp Gly Val Val Lys Asp Ala Glu Glu Ala Val Arg Ile 
        195                 200                 205             


Ala Arg Glu Ile Gly Tyr Pro Val Met Ile Lys Ala Ser Ala Gly Gly 
    210                 215                 220                 


Gly Gly Lys Gly Met Arg Ile Ala Trp Asp Asp Glu Glu Thr Arg Asp 
225                 230                 235                 240 


Gly Phe Arg Leu Ser Ser Gln Glu Ala Ala Ser Ser Phe Gly Asp Asp 
                245                 250                 255     


Arg Leu Leu Ile Glu Lys Phe Ile Asp Asn Pro Arg His Ile Glu Ile 
            260                 265                 270         


Gln Val Leu Gly Asp Lys His Gly Asn Ala Leu Trp Leu Asn Glu Arg 
        275                 280                 285             


Glu Cys Ser Ile Gln Arg Arg Asn Gln Lys Val Val Glu Glu Ala Pro 
    290                 295                 300                 


Ser Ile Phe Leu Asp Ala Glu Thr Arg Arg Ala Met Gly Glu Gln Ala 
305                 310                 315                 320 


Val Ala Leu Ala Arg Ala Val Lys Tyr Ser Ser Ala Gly Thr Val Glu 
                325                 330                 335     


Phe Leu Val Asp Ser Lys Lys Asn Phe Tyr Phe Leu Glu Met Asn Thr 
            340                 345                 350         


Arg Leu Gln Val Glu His Pro Val Thr Glu Cys Ile Thr Gly Leu Asp 
        355                 360                 365             


Leu Val Gln Glu Met Ile Arg Val Ala Lys Gly Tyr Pro Leu Arg His 
    370                 375                 380                 


Lys Gln Ala Asp Ile Arg Ile Asn Gly Trp Ala Val Glu Cys Arg Val 
385                 390                 395                 400 


Tyr Ala Glu Asp Pro Tyr Lys Ser Phe Gly Leu Pro Ser Ile Gly Arg 
                405                 410                 415     


Leu Ser Gln Tyr Gln Glu Pro Leu His Leu Pro Gly Val Arg Val Asp 
            420                 425                 430         


Ser Gly Ile Gln Pro Gly Ser Asp Ile Ser Ile Tyr Tyr Asp Pro Met 
        435                 440                 445             


Ile Ser Lys Leu Ile Thr Tyr Gly Ser Asp Arg Thr Glu Ala Leu Lys 
    450                 455                 460                 


Arg Met Ala Asp Ala Leu Asp Asn Tyr Val Ile Arg Gly Val Thr His 
465                 470                 475                 480 


Asn Ile Ala Leu Leu Arg Glu Val Ile Ile Asn Ser Arg Phe Val Lys 
                485                 490                 495     


Gly Asp Ile Ser Thr Lys Phe Leu Ser Asp Val Tyr Pro Asp Gly Phe 
            500                 505                 510         


Lys Gly His Met Leu Thr Lys Ser Glu Lys Asn Gln Leu Leu Ala Ile 
        515                 520                 525             


Ala Ser Ser Leu Phe Val Ala Phe Gln Leu Arg Ala Gln His Phe Gln 
    530                 535                 540                 


Glu Asn Ser Arg Met Pro Val Ile Lys Pro Asp Ile Ala Asn Trp Glu 
545                 550                 555                 560 


Leu Ser Val Lys Leu His Asp Lys Val His Thr Val Val Ala Ser Asn 
                565                 570                 575     


Asn Gly Ser Val Phe Ser Val Glu Val Asp Gly Ser Lys Leu Asn Val 
            580                 585                 590         


Thr Ser Thr Trp Asn Leu Ala Ser Pro Leu Leu Ser Val Ser Val Asp 
        595                 600                 605             


Gly Thr Gln Arg Thr Val Gln Cys Leu Ser Arg Glu Ala Gly Gly Asn 
    610                 615                 620                 


Met Ser Ile Gln Phe Leu Gly Thr Val Tyr Lys Val Asn Ile Leu Thr 
625                 630                 635                 640 


Arg Leu Ala Ala Glu Leu Asn Lys Phe Met Leu Glu Lys Val Thr Glu 
                645                 650                 655     


Asp Thr Ser Ser Val Leu Arg Ser Pro Met Pro Gly Val Val Val Ala 
            660                 665                 670         


Val Ser Val Lys Pro Gly Asp Ala Val Ala Glu Gly Gln Glu Ile Cys 
        675                 680                 685             


Val Ile Glu Ala Met Lys Met Gln Asn Ser Met Thr Ala Gly Lys Thr 
    690                 695                 700                 


Gly Thr Val Lys Ser Val His Cys Gln Ala Gly Asp Thr Val Gly Glu 
705                 710                 715                 720 


Gly Asp Leu Leu Val Glu Leu Glu 
                725             


<210>  759
<211>  996
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(996)

<400>  759
atg agt ggg gag aat gtc acc agg gtc ggc acc ttc atc ctg gtg ggc         48
Met Ser Gly Glu Asn Val Thr Arg Val Gly Thr Phe Ile Leu Val Gly           
1               5                   10                  15                

ttc ccc acg gcc cca ggg ctg cag tac ctg ctc ttc ctc ctc ttc ctg         96
Phe Pro Thr Ala Pro Gly Leu Gln Tyr Leu Leu Phe Leu Leu Phe Leu           
            20                  25                  30                    

ctc acc tac ctc ttt gtc ctg gtg gag aac ctg gcc atc atc ctc acc        144
Leu Thr Tyr Leu Phe Val Leu Val Glu Asn Leu Ala Ile Ile Leu Thr           
        35                  40                  45                        

gtc tgg agc agc acc tcc ctc cac agg ccc atg tac tac ttt ctg agc        192
Val Trp Ser Ser Thr Ser Leu His Arg Pro Met Tyr Tyr Phe Leu Ser           
    50                  55                  60                            

tcc atg tct ttc cta gag atc tgg tac gtg tct gac atc acc ccc aag        240
Ser Met Ser Phe Leu Glu Ile Trp Tyr Val Ser Asp Ile Thr Pro Lys           
65                  70                  75                  80            

atg ctg gag ggc ttc ctc ctc cag cag aaa cgc atc tct ttc gtc ggg        288
Met Leu Glu Gly Phe Leu Leu Gln Gln Lys Arg Ile Ser Phe Val Gly           
                85                  90                  95                

tgc atg acg cag ctc tac ttc ttc agc tcc ctg gtg tgc acc gag tgt        336
Cys Met Thr Gln Leu Tyr Phe Phe Ser Ser Leu Val Cys Thr Glu Cys           
            100                 105                 110                   

gtg ctt ctg gcc tcc atg gcc tac gac cgc tac gtg gcc atc tgc cac        384
Val Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His           
        115                 120                 125                       

ccg ctg cgc tac cac gtc ctt gtg acc ccg ggg ctg tgc ctc cag ctg        432
Pro Leu Arg Tyr His Val Leu Val Thr Pro Gly Leu Cys Leu Gln Leu           
    130                 135                 140                           

gtg ggc ttc tcc ttt gtg agt ggc ttc acc atc tcc atg atc aag gtc        480
Val Gly Phe Ser Phe Val Ser Gly Phe Thr Ile Ser Met Ile Lys Val           
145                 150                 155                 160           

tgt ttt atc tcc agc gtc acg ttc tgt ggc tcc aac gtc ttg aac cac        528
Cys Phe Ile Ser Ser Val Thr Phe Cys Gly Ser Asn Val Leu Asn His           
                165                 170                 175               

ttc ttc tgt gac att tcc ccc atc ctc aag ctg gcc tgc acg gac ttc        576
Phe Phe Cys Asp Ile Ser Pro Ile Leu Lys Leu Ala Cys Thr Asp Phe           
            180                 185                 190                   

tcc act gca gag ctg gtg gat ttc att ctg gcc ttc atc atc ctg gtg        624
Ser Thr Ala Glu Leu Val Asp Phe Ile Leu Ala Phe Ile Ile Leu Val           
        195                 200                 205                       

ttt cca ctc ctg gcc acc atg ctg tca tat gcg cac atc acc ctg gct        672
Phe Pro Leu Leu Ala Thr Met Leu Ser Tyr Ala His Ile Thr Leu Ala           
    210                 215                 220                           

gtc ctg cgc atc ccc tcg gcc acc ggc tgc tgg aga gcc ttc ttc acc        720
Val Leu Arg Ile Pro Ser Ala Thr Gly Cys Trp Arg Ala Phe Phe Thr           
225                 230                 235                 240           

tgc gcc tct cac ctc acc gtg gtc acc gtc ttc tat aca gcc ttg ctt        768
Cys Ala Ser His Leu Thr Val Val Thr Val Phe Tyr Thr Ala Leu Leu           
                245                 250                 255               

ttc atg tat gtc cgg ccc cag gcc att gat tcc cgg agc tcc aac aag        816
Phe Met Tyr Val Arg Pro Gln Ala Ile Asp Ser Arg Ser Ser Asn Lys           
            260                 265                 270                   

ctc atc tct gtt ttg tac aca gtt atc acc ccc atc ttg aac ccc ttg        864
Leu Ile Ser Val Leu Tyr Thr Val Ile Thr Pro Ile Leu Asn Pro Leu           
        275                 280                 285                       

ata tac tgc ctg agg aat aag gaa ttt aag aat gcc ttg aaa aaa gcc        912
Ile Tyr Cys Leu Arg Asn Lys Glu Phe Lys Asn Ala Leu Lys Lys Ala           
    290                 295                 300                           

ttc ggc ttg acg agc tgc gcc gta gag ggg agg ctt tct agt ctt ctg        960
Phe Gly Leu Thr Ser Cys Ala Val Glu Gly Arg Leu Ser Ser Leu Leu           
305                 310                 315                 320           

gaa ctt cat ctc caa ata cac agc cag cct ctc tga                        996
Glu Leu His Leu Gln Ile His Ser Gln Pro Leu                               
                325                 330                                   


<210>  760
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  760

Met Ser Gly Glu Asn Val Thr Arg Val Gly Thr Phe Ile Leu Val Gly 
1               5                   10                  15      


Phe Pro Thr Ala Pro Gly Leu Gln Tyr Leu Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Leu Thr Tyr Leu Phe Val Leu Val Glu Asn Leu Ala Ile Ile Leu Thr 
        35                  40                  45              


Val Trp Ser Ser Thr Ser Leu His Arg Pro Met Tyr Tyr Phe Leu Ser 
    50                  55                  60                  


Ser Met Ser Phe Leu Glu Ile Trp Tyr Val Ser Asp Ile Thr Pro Lys 
65                  70                  75                  80  


Met Leu Glu Gly Phe Leu Leu Gln Gln Lys Arg Ile Ser Phe Val Gly 
                85                  90                  95      


Cys Met Thr Gln Leu Tyr Phe Phe Ser Ser Leu Val Cys Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr His Val Leu Val Thr Pro Gly Leu Cys Leu Gln Leu 
    130                 135                 140                 


Val Gly Phe Ser Phe Val Ser Gly Phe Thr Ile Ser Met Ile Lys Val 
145                 150                 155                 160 


Cys Phe Ile Ser Ser Val Thr Phe Cys Gly Ser Asn Val Leu Asn His 
                165                 170                 175     


Phe Phe Cys Asp Ile Ser Pro Ile Leu Lys Leu Ala Cys Thr Asp Phe 
            180                 185                 190         


Ser Thr Ala Glu Leu Val Asp Phe Ile Leu Ala Phe Ile Ile Leu Val 
        195                 200                 205             


Phe Pro Leu Leu Ala Thr Met Leu Ser Tyr Ala His Ile Thr Leu Ala 
    210                 215                 220                 


Val Leu Arg Ile Pro Ser Ala Thr Gly Cys Trp Arg Ala Phe Phe Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Thr Val Val Thr Val Phe Tyr Thr Ala Leu Leu 
                245                 250                 255     


Phe Met Tyr Val Arg Pro Gln Ala Ile Asp Ser Arg Ser Ser Asn Lys 
            260                 265                 270         


Leu Ile Ser Val Leu Tyr Thr Val Ile Thr Pro Ile Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Cys Leu Arg Asn Lys Glu Phe Lys Asn Ala Leu Lys Lys Ala 
    290                 295                 300                 


Phe Gly Leu Thr Ser Cys Ala Val Glu Gly Arg Leu Ser Ser Leu Leu 
305                 310                 315                 320 


Glu Leu His Leu Gln Ile His Ser Gln Pro Leu 
                325                 330     


<210>  761
<211>  961
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (347)..(634)

<400>  761
gaggacaagc agcctgccca gaagtggaag aaactgaaag tggagtcctg agagctgaat       60

ctgccgcagg cccgcgggcc gcccgggaat taggaaagtt agaggggatc cacgcccaca      120

agtgctatgg actctgatcg cccaaccaga gcaaacccag aaggacaact ctccaagcct      180

ttcaatcact cccactaacc cgtattgtgg acacactatt gtgaggccta ctaaggatgt      240

actgctgatg accttttgaa gagtggctag tggttggccc atgtaggctg agctcagctg      300

gtccatcctt cttggaccca cagactccct ggggcatgtt cttctc atg atg atg         355
                                                   Met Met Met            
                                                   1                      

act gca aca cag agg gca aga cat cct aca caa gca cat ttc aag att        403
Thr Ala Thr Gln Arg Ala Arg His Pro Thr Gln Ala His Phe Lys Ile           
    5                   10                  15                            

ttg ctc gca tca tct ctg cta aaa ttc ctt tat cca aag caa gga aca        451
Leu Leu Ala Ser Ser Leu Leu Lys Phe Leu Tyr Pro Lys Gln Gly Thr           
20                  25                  30                  35            

caa ctg gtt caa ata agc aca ggc ctc caa ata tcc aga tct aaa aat        499
Gln Leu Val Gln Ile Ser Thr Gly Leu Gln Ile Ser Arg Ser Lys Asn           
                40                  45                  50                

gga gtg ttc acc tca gct cct tat tta tca ctg caa gag att ctg ggg        547
Gly Val Phe Thr Ser Ala Pro Tyr Leu Ser Leu Gln Glu Ile Leu Gly           
            55                  60                  65                    

ctg gca gct agt gac atg agc tgg aat cct ctt cct gaa att gct gtc        595
Leu Ala Ala Ser Asp Met Ser Trp Asn Pro Leu Pro Glu Ile Ala Val           
        70                  75                  80                        

ttc ttg gat ggg ctc tcc aca tct tcc acc acg aag taa aaacaattct         644
Phe Leu Asp Gly Leu Ser Thr Ser Ser Thr Thr Lys                           
    85                  90                  95                            

tgtgggtgcc agtggacctg ctctgcagac ccaggctcct ctcccatgga gcatcccaag      704

tctgtcctta tgggaagaag caggagccct gtctggctgt accccaagct gctttctctg      764

gaccaatgct gtcagcgata gagggaaccc ttccaccatc atgtgaagaa gcctggtcta      824

gcctgctgga ggatgagaga tcacatggaa tgaggccaca atcgttccag ccaaagcccc      884

agtaatagaa ttaagatcat ccaagaccat ggcatcccgc ctgagaagtt cagatgagaa      944

gggccacctg aacaacc                                                     961


<210>  762
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  762

Met Met Met Thr Ala Thr Gln Arg Ala Arg His Pro Thr Gln Ala His 
1               5                   10                  15      


Phe Lys Ile Leu Leu Ala Ser Ser Leu Leu Lys Phe Leu Tyr Pro Lys 
            20                  25                  30          


Gln Gly Thr Gln Leu Val Gln Ile Ser Thr Gly Leu Gln Ile Ser Arg 
        35                  40                  45              


Ser Lys Asn Gly Val Phe Thr Ser Ala Pro Tyr Leu Ser Leu Gln Glu 
    50                  55                  60                  


Ile Leu Gly Leu Ala Ala Ser Asp Met Ser Trp Asn Pro Leu Pro Glu 
65                  70                  75                  80  


Ile Ala Val Phe Leu Asp Gly Leu Ser Thr Ser Ser Thr Thr Lys 
                85                  90                  95  


<210>  763
<211>  6540
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (143)..(4237)

<400>  763
gcggcagccc gggactccgg cgagagcgac gcaaggtcgg ctgcggcggc ggcccgaggg       60

cgcccgtgtg cccagtgcgc ggcggggacg gccgcgagct cgctggaggg ctccccagaa      120

taatccagaa gtcgattcca tc atg gca gaa ctc aag gtg gag gcg ccg gcc       172
                         Met Ala Glu Leu Lys Val Glu Ala Pro Ala          
                         1               5                   10           

agc gta gac tgg cag aaa cgc tgc ctg acc ctg gaa act cag ctt ttc        220
Ser Val Asp Trp Gln Lys Arg Cys Leu Thr Leu Glu Thr Gln Leu Phe           
                15                  20                  25                

cgg ttc cgc cta cag gcc agc aag ata agg gag ctg ctg gct gac aag        268
Arg Phe Arg Leu Gln Ala Ser Lys Ile Arg Glu Leu Leu Ala Asp Lys           
            30                  35                  40                    

atg cag gag ctg gag cag agg ctg ctg gag gca gag cag aga gca gag        316
Met Gln Glu Leu Glu Gln Arg Leu Leu Glu Ala Glu Gln Arg Ala Glu           
        45                  50                  55                        

aac gct gag acc cag gtg ggt gtc atg gaa gag aag gta aaa cta tcc        364
Asn Ala Glu Thr Gln Val Gly Val Met Glu Glu Lys Val Lys Leu Ser           
    60                  65                  70                            

aat ctg aag aat gtg gac tct gag ggg agc ctg cac cgg aaa tac caa        412
Asn Leu Lys Asn Val Asp Ser Glu Gly Ser Leu His Arg Lys Tyr Gln           
75                  80                  85                  90            

gaa ttg ctg aaa gcc ata aag ggc aaa gat gag ctc atc agc cag cta        460
Glu Leu Leu Lys Ala Ile Lys Gly Lys Asp Glu Leu Ile Ser Gln Leu           
                95                  100                 105               

gag gct cag ctg gag aag cag aag cag atg agg gca gag gaa gca aaa        508
Glu Ala Gln Leu Glu Lys Gln Lys Gln Met Arg Ala Glu Glu Ala Lys           
            110                 115                 120                   

act gtt caa gaa aaa gct gca aag atc aag gaa tgg gtg aca ctc aag        556
Thr Val Gln Glu Lys Ala Ala Lys Ile Lys Glu Trp Val Thr Leu Lys           
        125                 130                 135                       

ttg gca aag ctt gag atg gag aat cag cat ctg aaa agc cat aat cag        604
Leu Ala Lys Leu Glu Met Glu Asn Gln His Leu Lys Ser His Asn Gln           
    140                 145                 150                           

cgc ctg gtg gag cag gtg gga tcc ctt caa gat gcg cta gaa gct att        652
Arg Leu Val Glu Gln Val Gly Ser Leu Gln Asp Ala Leu Glu Ala Ile           
155                 160                 165                 170           

cag ata gct cct tca cgg aag ctg ctg gtg ccc ccc tac gga gct gca        700
Gln Ile Ala Pro Ser Arg Lys Leu Leu Val Pro Pro Tyr Gly Ala Ala           
                175                 180                 185               

gag cag gat tct gtc cct tca gag ccg gga atc cag cct atg ggc cag        748
Glu Gln Asp Ser Val Pro Ser Glu Pro Gly Ile Gln Pro Met Gly Gln           
            190                 195                 200                   

gac agt ggc tcc cag gcc cag ggt ctg aag gca gct gtg ctt gca cct        796
Asp Ser Gly Ser Gln Ala Gln Gly Leu Lys Ala Ala Val Leu Ala Pro           
        205                 210                 215                       

tcc cca ggt gcc ctg cag agc aag gac tct gtt tct gaa gca gca agc        844
Ser Pro Gly Ala Leu Gln Ser Lys Asp Ser Val Ser Glu Ala Ala Ser           
    220                 225                 230                           

ccc ttg gag gat tct agt tcc agc acg gtc cat tct ggg gaa aca gta        892
Pro Leu Glu Asp Ser Ser Ser Ser Thr Val His Ser Gly Glu Thr Val           
235                 240                 245                 250           

gag gcc aag ccc ctt caa cct cat ctg gga aga gag agc cct ccc cac        940
Glu Ala Lys Pro Leu Gln Pro His Leu Gly Arg Glu Ser Pro Pro His           
                255                 260                 265               

cag cca tgc atg aag ctt ctt acc ttc aga tgt agt tca gct tcc tgg        988
Gln Pro Cys Met Lys Leu Leu Thr Phe Arg Cys Ser Ser Ala Ser Trp           
            270                 275                 280                   

ggt gag ggt ctg gtt act gct cag aga ggg atg ctc cct ggg aca aag       1036
Gly Glu Gly Leu Val Thr Ala Gln Arg Gly Met Leu Pro Gly Thr Lys           
        285                 290                 295                       

acc tct gcc agg gaa ggt ggt cct ggc agc agt ctg acc cta cca aag       1084
Thr Ser Ala Arg Glu Gly Gly Pro Gly Ser Ser Leu Thr Leu Pro Lys           
    300                 305                 310                           

gtg cgg gct cct ggc acc ccg cgg gac agc atc cag ttg gcc aaa agg       1132
Val Arg Ala Pro Gly Thr Pro Arg Asp Ser Ile Gln Leu Ala Lys Arg           
315                 320                 325                 330           

cac cac agc cag ccc cag gtg ggc cat ggg cac ttt ggc cgt gtg gtg       1180
His His Ser Gln Pro Gln Val Gly His Gly His Phe Gly Arg Val Val           
                335                 340                 345               

aac att gag act gag gcc ttc tca gcc ctc cac ccc tct ggc ctt cct       1228
Asn Ile Glu Thr Glu Ala Phe Ser Ala Leu His Pro Ser Gly Leu Pro           
            350                 355                 360                   

gag ctg gag tcc cga gct agg tcc cgg gag gaa cca gag aag atg gag       1276
Glu Leu Glu Ser Arg Ala Arg Ser Arg Glu Glu Pro Glu Lys Met Glu           
        365                 370                 375                       

atg gag gag cca ccc cca gca ggg aag aat gag gaa aga gag agc cca       1324
Met Glu Glu Pro Pro Pro Ala Gly Lys Asn Glu Glu Arg Glu Ser Pro           
    380                 385                 390                           

aag gcc ctt gga gct gag ctg gag gaa gtg gag ctg ggt aac aag cca       1372
Lys Ala Leu Gly Ala Glu Leu Glu Glu Val Glu Leu Gly Asn Lys Pro           
395                 400                 405                 410           

cct aca ccc ccg ctg cac cag ttt tca tcc tgg gag agc cgg atc tat       1420
Pro Thr Pro Pro Leu His Gln Phe Ser Ser Trp Glu Ser Arg Ile Tyr           
                415                 420                 425               

gct gtg gcc aca tcg ggc atg cgg ctc tca gat atg tct ccc aga agt       1468
Ala Val Ala Thr Ser Gly Met Arg Leu Ser Asp Met Ser Pro Arg Ser           
            430                 435                 440                   

aat act gca tgc tgc gct tca agc cct cct gcc ctt gtt tcc cct ggg       1516
Asn Thr Ala Cys Cys Ala Ser Ser Pro Pro Ala Leu Val Ser Pro Gly           
        445                 450                 455                       

tct ttc tct ggc ctg gtc tac aag aat gtc act gtg cct gtc tac aca       1564
Ser Phe Ser Gly Leu Val Tyr Lys Asn Val Thr Val Pro Val Tyr Thr           
    460                 465                 470                           

gca ctg aag ggg aga gct aca cag atc agc aac atg ccc ttt atg gac       1612
Ala Leu Lys Gly Arg Ala Thr Gln Ile Ser Asn Met Pro Phe Met Asp           
475                 480                 485                 490           

gag tcc tct ggg tct gac gat gac tgc agc tct cag gcg agt ttc cga       1660
Glu Ser Ser Gly Ser Asp Asp Asp Cys Ser Ser Gln Ala Ser Phe Arg           
                495                 500                 505               

atc tcg gtc ccc tcc tct gag tcc agg aag acc agc gga cta ggc agc       1708
Ile Ser Val Pro Ser Ser Glu Ser Arg Lys Thr Ser Gly Leu Gly Ser           
            510                 515                 520                   

ccc cgg gcc atc aag aga ggc gtc tcc atg tcc tca ctg agc tcc gag       1756
Pro Arg Ala Ile Lys Arg Gly Val Ser Met Ser Ser Leu Ser Ser Glu           
        525                 530                 535                       

ggt gac tac gcc atc ccc ccg gac gcc tgc tca ctg gac agt gac tac       1804
Gly Asp Tyr Ala Ile Pro Pro Asp Ala Cys Ser Leu Asp Ser Asp Tyr           
    540                 545                 550                           

tca gag cct gag cac aaa ctg cag cgc acc tca tcc tac tcc acc gac       1852
Ser Glu Pro Glu His Lys Leu Gln Arg Thr Ser Ser Tyr Ser Thr Asp           
555                 560                 565                 570           

ggg ctg ggc ctg ggc ggg gag tca ctg gag aag tcg ggc tac ctg ctg       1900
Gly Leu Gly Leu Gly Gly Glu Ser Leu Glu Lys Ser Gly Tyr Leu Leu           
                575                 580                 585               

aaa atg ggg agc cag gtg aag acg tgg aag agg cgc tgg ttt gtc ctg       1948
Lys Met Gly Ser Gln Val Lys Thr Trp Lys Arg Arg Trp Phe Val Leu           
            590                 595                 600                   

aga cag gga cag att atg tac tac aag tcc ccg agt gat gtc atc cgg       1996
Arg Gln Gly Gln Ile Met Tyr Tyr Lys Ser Pro Ser Asp Val Ile Arg           
        605                 610                 615                       

aaa cct caa ggc caa gtg gat ctg aac tcc cgc tgc caa att gtt cga       2044
Lys Pro Gln Gly Gln Val Asp Leu Asn Ser Arg Cys Gln Ile Val Arg           
    620                 625                 630                           

ggg gag ggt tca cag acg ttt cag ctc atc tct gag aag aaa acc tac       2092
Gly Glu Gly Ser Gln Thr Phe Gln Leu Ile Ser Glu Lys Lys Thr Tyr           
635                 640                 645                 650           

tac ctg acg gcc gat tca ccc agc ctg ctg gag gag tgg atc cga gta       2140
Tyr Leu Thr Ala Asp Ser Pro Ser Leu Leu Glu Glu Trp Ile Arg Val           
                655                 660                 665               

ctc cag agc ctg ctg aag gtg cag gcc acc ggg cct cca gct ctg ctt       2188
Leu Gln Ser Leu Leu Lys Val Gln Ala Thr Gly Pro Pro Ala Leu Leu           
            670                 675                 680                   

cgg ggt ggc acc aag ccc acc gtg aag ggc tgg ctg acc aag gta aag       2236
Arg Gly Gly Thr Lys Pro Thr Val Lys Gly Trp Leu Thr Lys Val Lys           
        685                 690                 695                       

cat ggc cac tcc aag gtg gtc tgg tgc gct ctt gtt ggg aaa atc ttc       2284
His Gly His Ser Lys Val Val Trp Cys Ala Leu Val Gly Lys Ile Phe           
    700                 705                 710                           

tac tac tat cgg agc cat gag gac aag cga ccc ctg ggc tgc ctg cct       2332
Tyr Tyr Tyr Arg Ser His Glu Asp Lys Arg Pro Leu Gly Cys Leu Pro           
715                 720                 725                 730           

gtg cgg gat gcg cac ata gag gaa gta gat cga tcc tgt gac tca gac       2380
Val Arg Asp Ala His Ile Glu Glu Val Asp Arg Ser Cys Asp Ser Asp           
                735                 740                 745               

gag gac tat gag gct gga gga acc aga cgg ttg ctt tcc tcc cac tgc       2428
Glu Asp Tyr Glu Ala Gly Gly Thr Arg Arg Leu Leu Ser Ser His Cys           
            750                 755                 760                   

acc ctg gtg atc cac ccc aca gag cac agc ccc acc tac ctc ctc att       2476
Thr Leu Val Ile His Pro Thr Glu His Ser Pro Thr Tyr Leu Leu Ile           
        765                 770                 775                       

ggc acc aag cat gaa aag gat acg tgg ctc tac cac ctc aca gtg gct       2524
Gly Thr Lys His Glu Lys Asp Thr Trp Leu Tyr His Leu Thr Val Ala           
    780                 785                 790                           

gca ggt ggc agc agt gcc aag gtg ggc act gcc tat gag cag ctc att       2572
Ala Gly Gly Ser Ser Ala Lys Val Gly Thr Ala Tyr Glu Gln Leu Ile           
795                 800                 805                 810           

gga aaa ctg atg gat ggt gaa gga gat cca gat tcg ccg ctc tgg agg       2620
Gly Lys Leu Met Asp Gly Glu Gly Asp Pro Asp Ser Pro Leu Trp Arg           
                815                 820                 825               

cac ccc atg ctg tgc tac agc aaa gac ggc cta tac gcc tcc ctc acc       2668
His Pro Met Leu Cys Tyr Ser Lys Asp Gly Leu Tyr Ala Ser Leu Thr           
            830                 835                 840                   

acc ctg ccc tct gag gcc ttg cag acg gag gcc ctc aag ctc ttc aag       2716
Thr Leu Pro Ser Glu Ala Leu Gln Thr Glu Ala Leu Lys Leu Phe Lys           
        845                 850                 855                       

tcc tgc cag ctc ttc atc aac gtg ccg gtg gaa gct gcc tcg gtg gac       2764
Ser Cys Gln Leu Phe Ile Asn Val Pro Val Glu Ala Ala Ser Val Asp           
    860                 865                 870                           

tac cat gtg tcc ctg gcc cag acc gca ctg cag gtc tgc ctg gtt cac       2812
Tyr His Val Ser Leu Ala Gln Thr Ala Leu Gln Val Cys Leu Val His           
875                 880                 885                 890           

ccc gag ctg cag agt gag atc tac tgc caa ctc atg aag cag acc agc       2860
Pro Glu Leu Gln Ser Glu Ile Tyr Cys Gln Leu Met Lys Gln Thr Ser           
                895                 900                 905               

tgc cgc cca cct cag aag tac tcc ctc atg cag tgc tgg cag ctc ctc       2908
Cys Arg Pro Pro Gln Lys Tyr Ser Leu Met Gln Cys Trp Gln Leu Leu           
            910                 915                 920                   

gct ctg tgt gct cca ctt ttc ctg cct cag cat cac ttc ctc tgg tat       2956
Ala Leu Cys Ala Pro Leu Phe Leu Pro Gln His His Phe Leu Trp Tyr           
        925                 930                 935                       

gtc aag cag cag ctc caa cgc cat gca gat ccc aga agt gaa act ggc       3004
Val Lys Gln Gln Leu Gln Arg His Ala Asp Pro Arg Ser Glu Thr Gly           
    940                 945                 950                           

cag tat gcc acc tac tgc cag cgg gca gtg gag cgg acc ctg cgg acc       3052
Gln Tyr Ala Thr Tyr Cys Gln Arg Ala Val Glu Arg Thr Leu Arg Thr           
955                 960                 965                 970           

ggg gag cgg gaa gcc agg cca tcg cgc atg gaa gtg gtg tcc atc ctg       3100
Gly Glu Arg Glu Ala Arg Pro Ser Arg Met Glu Val Val Ser Ile Leu           
                975                 980                 985               

ctg cgt aac ccc ttc cac cac tcc ttg ccc ttc agc atc ccc  gtg cac      3148
Leu Arg Asn Pro Phe His His Ser Leu Pro Phe Ser Ile Pro  Val His          
            990                 995                 1000                  

ttt acc aac  ggg act tac cat gtg  gtt ggt ttt gac ggc  tct tcc        3193
Phe Thr Asn  Gly Thr Tyr His Val  Val Gly Phe Asp Gly  Ser Ser            
        1005                 1010                 1015                    

acg gtt gat  gag ttc ctc cag cgg  ctg aac cag gag ata  ggc atg        3238
Thr Val Asp  Glu Phe Leu Gln Arg  Leu Asn Gln Glu Ile  Gly Met            
        1020                 1025                 1030                    

aga aag cca  tcc cac tct ggc ttt  gcc ctc ttc acg gac  gat ccc        3283
Arg Lys Pro  Ser His Ser Gly Phe  Ala Leu Phe Thr Asp  Asp Pro            
        1035                 1040                 1045                    

tcg ggc agg  gac ctg gag cac tgc  ctg cag gga agt gtc  aag atc        3328
Ser Gly Arg  Asp Leu Glu His Cys  Leu Gln Gly Ser Val  Lys Ile            
        1050                 1055                 1060                    

tgt gat gcc  atc tcc aag tgg gaa  caa gcc atg aag gag  ctg cac        3373
Cys Asp Ala  Ile Ser Lys Trp Glu  Gln Ala Met Lys Glu  Leu His            
        1065                 1070                 1075                    

ccc gga aag  tct gag ggt ggg aca  cgc gtc gtg aag ctg  atg tac        3418
Pro Gly Lys  Ser Glu Gly Gly Thr  Arg Val Val Lys Leu  Met Tyr            
        1080                 1085                 1090                    

aag aac agg  ctg tac ttt cgc agt  caa gtc aaa ggg gag  acg gac        3463
Lys Asn Arg  Leu Tyr Phe Arg Ser  Gln Val Lys Gly Glu  Thr Asp            
        1095                 1100                 1105                    

cga gaa cgg  ctg ctc ctt gcc tct  caa acc agt aga gag  ata gtg        3508
Arg Glu Arg  Leu Leu Leu Ala Ser  Gln Thr Ser Arg Glu  Ile Val            
        1110                 1115                 1120                    

gca ggg agg  ttt cct atc aac aag  gaa ttg gct ctt gag  atg gct        3553
Ala Gly Arg  Phe Pro Ile Asn Lys  Glu Leu Ala Leu Glu  Met Ala            
        1125                 1130                 1135                    

gcc ctg atg  gcc cag gta gaa tat  ggg gac ttg gag aag  cct gcc        3598
Ala Leu Met  Ala Gln Val Glu Tyr  Gly Asp Leu Glu Lys  Pro Ala            
        1140                 1145                 1150                    

ctg cca ggc  cct gga ggc aca tcc  cct gcc aag gct cag  cat ctt        3643
Leu Pro Gly  Pro Gly Gly Thr Ser  Pro Ala Lys Ala Gln  His Leu            
        1155                 1160                 1165                    

ctc cag cag  gtc cta gac agg ttc  cac ccc agg cgc tat  aga cat        3688
Leu Gln Gln  Val Leu Asp Arg Phe  His Pro Arg Arg Tyr  Arg His            
        1170                 1175                 1180                    

ggg gcc ccc  gct gaa cag ctg agg  cac ctg gca gat atg  ttg acc        3733
Gly Ala Pro  Ala Glu Gln Leu Arg  His Leu Ala Asp Met  Leu Thr            
        1185                 1190                 1195                    

aca aaa tgg  gca aca ttg caa gga  tgc tcc cct cct gag  tgc atc        3778
Thr Lys Trp  Ala Thr Leu Gln Gly  Cys Ser Pro Pro Glu  Cys Ile            
        1200                 1205                 1210                    

cgc atc tac  ctg acc gtg gcc agg  aaa tgg cct ttc ttt  ggt gct        3823
Arg Ile Tyr  Leu Thr Val Ala Arg  Lys Trp Pro Phe Phe  Gly Ala            
        1215                 1220                 1225                    

aaa ctt ttt  gct gct cag cct gcc  cag ctg tct tcc aag  gag aac        3868
Lys Leu Phe  Ala Ala Gln Pro Ala  Gln Leu Ser Ser Lys  Glu Asn            
        1230                 1235                 1240                    

gct ctg gtg  tgg att gct gtg aat  gag gat ggc gtc agc  atc ctg        3913
Ala Leu Val  Trp Ile Ala Val Asn  Glu Asp Gly Val Ser  Ile Leu            
        1245                 1250                 1255                    

gac cac aac  act atg caa gtg cac  atc act tac ccc tac  tct tca        3958
Asp His Asn  Thr Met Gln Val His  Ile Thr Tyr Pro Tyr  Ser Ser            
        1260                 1265                 1270                    

gtg aca acg  ttt ggt ggc tgc agg  gat gac ttc atg ctt  gtg att        4003
Val Thr Thr  Phe Gly Gly Cys Arg  Asp Asp Phe Met Leu  Val Ile            
        1275                 1280                 1285                    

aga tct atc  cca gac aag agc tct  gga aaa agc cac att  gag aag        4048
Arg Ser Ile  Pro Asp Lys Ser Ser  Gly Lys Ser His Ile  Glu Lys            
        1290                 1295                 1300                    

ttg atc ttc  cgg atg gct gct ccc  aag att gca gaa gct  acc ttc        4093
Leu Ile Phe  Arg Met Ala Ala Pro  Lys Ile Ala Glu Ala  Thr Phe            
        1305                 1310                 1315                    

atc atg gcc  agc tat atg aac cat  tgc act aca act gtg  aac ccc        4138
Ile Met Ala  Ser Tyr Met Asn His  Cys Thr Thr Thr Val  Asn Pro            
        1320                 1325                 1330                    

ccc acc aac  cca ccc gga gcc tgc  cag ctg tgg gaa ctg  gat gga        4183
Pro Thr Asn  Pro Pro Gly Ala Cys  Gln Leu Trp Glu Leu  Asp Gly            
        1335                 1340                 1345                    

cga cag ttc  ttt tct tct gtt tcc  tgt gct acc aag ggg  cca acg        4228
Arg Gln Phe  Phe Ser Ser Val Ser  Cys Ala Thr Lys Gly  Pro Thr            
        1350                 1355                 1360                    

ttg ctg tga atatttctcc tacccgattc cccaacacca ctagtgcctc               4277
Leu Leu                                                                   
                                                                          

tggatttaga gatatatatc ctagggtatg atactactgt gacgggtcta acagcccccg     4337

gctactcttg ttctgtgaaa tgtgtatttt agtctctgtg aagcctttac tctctaggtg     4397

ccttataatg tttcagggct caacttttta aaatccagac ccagtgttaa aaccatttat     4457

tccttttttc ataagaataa tgactccaga tgctacctga ttctagacat agacagggat     4517

gatccactgt tactgagggc atcagtgcta taagttaagg ctttctgcac tggtactctc     4577

aaggaagcta attttctttc tggggggggc gggggacaca gtgtcactat gtcacccagt     4637

ccacagggtt caagcaattc tcctgcctca gccttcggag tggctgggat tacaggtgtg     4697

cgccaccatg cccggctaat ttttgtattt ttagtagaga cggggtttca ccatgttggc     4757

caggctggtc tcgaactcct gacctcaggt gatctgccca ctttggcctc ccaaagtgct     4817

gggattacag gcatgagcca tcgcccagcc cagaagctaa ttttttaata ttgtatatgg     4877

tcttatttat acttgaagtt ttgtgaacgt cgctaaacag gataggacta aaatttccaa     4937

ttctcctaca ctctgtcaga agcctagaac tcactaaact gggctgcctt tcccaaatgg     4997

gaaaggtgct gacagagttg gagaaaaaag aatagactca tttttcccca ttattggtat     5057

gtaggcattg gtacagcccc ttctggggca gtctttgcag gataacatgc tatacctgct     5117

aagattcaag ctgttttcct cacactggac tttaggccaa acccagtacc acgcaatgtg     5177

caagcaaggg caggaggtag gtccaatctg acccctccct gtctcatttt aatgactgga     5237

cagcgctcgg tgaaggctgt gttcactgta gtgggccatc atttgtttcc ttcttcttgt     5297

aaaagaccaa gcaaatgcac tctgcttttt gctgctgtaa gaccaccaaa aatgagtcag     5357

aaacacagaa gactatttca ggcatgtggg cctggatatg ctccttgaga cttctggcaa     5417

acttctgctg ggaattagtt tgagggtgag ggtacatatg tgacatttgc cctagcctaa     5477

gagtagcagg taaaaaaaag tttctttcat cttttgcctt actgataata ccataatccc     5537

cctcaattca gaccttctga ttgagtgcag aggagactag acagtctcct ctagacaggt     5597

tgtagacaca ccctccccta acaaaaacaa aacgaaagag ttcatactct gattttccaa     5657

catctaggaa actgagtttt atttcctagc tctaaggcag ccttactata tgtcagtaaa     5717

gtgctgaaaa ctgtatattt agcagtagca cccaaaacca agcctttaac cccaacaatg     5777

tgtgtatctt ttgcacagca aaaactgcga ggccagaact agtttatctg aacacctcag     5837

ctgctgtaag cttctcctct ctcaccccgt aaactgacaa gcatgatgaa aaaagaagca     5897

catccaagtt tctgcctctt ttaaatgtac ttgactttgc aaggcaagta gttttacagc     5957

catttctgtt cacacttttc accccacaac ttggggatct agctgagaca tttctacctc     6017

gaacaagtca catgtaccac aggttcctga ataattcctg cagggctggt gacagacata     6077

acagctctgg ttttataata tcttgggtat ctctaaggcc aataaggata acattatcta     6137

cccagagagt ttagaagaaa agtaggagtc caaaggaaga gtaaacaaga atggagctgt     6197

gttcacactg aatttggggt caatctattt cccccaccct ctctcctccc caacccttca     6257

ggaacccttt agtttattaa tcttatacag aagaaactaa cttagaaaca aaggattcaa     6317

tatttgctta tttattcttt gttaacatga gagtcccatg tctgaaaacc aaagtccaat     6377

ttctgtctgg ccttttgtct catccttctt ggcaaaagta gcttttgaac tgatataaaa     6437

aaaaatgctg agtaacagaa aagtattaat gtgcttgaca ccatgactga aatactatga     6497

tcttgtttgt caataaaaag cagctatctg tgaaccaggt aac                       6540


<210>  764
<211>  1364
<212>  PRT
<213>  Homo sapiens

<400>  764

Met Ala Glu Leu Lys Val Glu Ala Pro Ala Ser Val Asp Trp Gln Lys 
1               5                   10                  15      


Arg Cys Leu Thr Leu Glu Thr Gln Leu Phe Arg Phe Arg Leu Gln Ala 
            20                  25                  30          


Ser Lys Ile Arg Glu Leu Leu Ala Asp Lys Met Gln Glu Leu Glu Gln 
        35                  40                  45              


Arg Leu Leu Glu Ala Glu Gln Arg Ala Glu Asn Ala Glu Thr Gln Val 
    50                  55                  60                  


Gly Val Met Glu Glu Lys Val Lys Leu Ser Asn Leu Lys Asn Val Asp 
65                  70                  75                  80  


Ser Glu Gly Ser Leu His Arg Lys Tyr Gln Glu Leu Leu Lys Ala Ile 
                85                  90                  95      


Lys Gly Lys Asp Glu Leu Ile Ser Gln Leu Glu Ala Gln Leu Glu Lys 
            100                 105                 110         


Gln Lys Gln Met Arg Ala Glu Glu Ala Lys Thr Val Gln Glu Lys Ala 
        115                 120                 125             


Ala Lys Ile Lys Glu Trp Val Thr Leu Lys Leu Ala Lys Leu Glu Met 
    130                 135                 140                 


Glu Asn Gln His Leu Lys Ser His Asn Gln Arg Leu Val Glu Gln Val 
145                 150                 155                 160 


Gly Ser Leu Gln Asp Ala Leu Glu Ala Ile Gln Ile Ala Pro Ser Arg 
                165                 170                 175     


Lys Leu Leu Val Pro Pro Tyr Gly Ala Ala Glu Gln Asp Ser Val Pro 
            180                 185                 190         


Ser Glu Pro Gly Ile Gln Pro Met Gly Gln Asp Ser Gly Ser Gln Ala 
        195                 200                 205             


Gln Gly Leu Lys Ala Ala Val Leu Ala Pro Ser Pro Gly Ala Leu Gln 
    210                 215                 220                 


Ser Lys Asp Ser Val Ser Glu Ala Ala Ser Pro Leu Glu Asp Ser Ser 
225                 230                 235                 240 


Ser Ser Thr Val His Ser Gly Glu Thr Val Glu Ala Lys Pro Leu Gln 
                245                 250                 255     


Pro His Leu Gly Arg Glu Ser Pro Pro His Gln Pro Cys Met Lys Leu 
            260                 265                 270         


Leu Thr Phe Arg Cys Ser Ser Ala Ser Trp Gly Glu Gly Leu Val Thr 
        275                 280                 285             


Ala Gln Arg Gly Met Leu Pro Gly Thr Lys Thr Ser Ala Arg Glu Gly 
    290                 295                 300                 


Gly Pro Gly Ser Ser Leu Thr Leu Pro Lys Val Arg Ala Pro Gly Thr 
305                 310                 315                 320 


Pro Arg Asp Ser Ile Gln Leu Ala Lys Arg His His Ser Gln Pro Gln 
                325                 330                 335     


Val Gly His Gly His Phe Gly Arg Val Val Asn Ile Glu Thr Glu Ala 
            340                 345                 350         


Phe Ser Ala Leu His Pro Ser Gly Leu Pro Glu Leu Glu Ser Arg Ala 
        355                 360                 365             


Arg Ser Arg Glu Glu Pro Glu Lys Met Glu Met Glu Glu Pro Pro Pro 
    370                 375                 380                 


Ala Gly Lys Asn Glu Glu Arg Glu Ser Pro Lys Ala Leu Gly Ala Glu 
385                 390                 395                 400 


Leu Glu Glu Val Glu Leu Gly Asn Lys Pro Pro Thr Pro Pro Leu His 
                405                 410                 415     


Gln Phe Ser Ser Trp Glu Ser Arg Ile Tyr Ala Val Ala Thr Ser Gly 
            420                 425                 430         


Met Arg Leu Ser Asp Met Ser Pro Arg Ser Asn Thr Ala Cys Cys Ala 
        435                 440                 445             


Ser Ser Pro Pro Ala Leu Val Ser Pro Gly Ser Phe Ser Gly Leu Val 
    450                 455                 460                 


Tyr Lys Asn Val Thr Val Pro Val Tyr Thr Ala Leu Lys Gly Arg Ala 
465                 470                 475                 480 


Thr Gln Ile Ser Asn Met Pro Phe Met Asp Glu Ser Ser Gly Ser Asp 
                485                 490                 495     


Asp Asp Cys Ser Ser Gln Ala Ser Phe Arg Ile Ser Val Pro Ser Ser 
            500                 505                 510         


Glu Ser Arg Lys Thr Ser Gly Leu Gly Ser Pro Arg Ala Ile Lys Arg 
        515                 520                 525             


Gly Val Ser Met Ser Ser Leu Ser Ser Glu Gly Asp Tyr Ala Ile Pro 
    530                 535                 540                 


Pro Asp Ala Cys Ser Leu Asp Ser Asp Tyr Ser Glu Pro Glu His Lys 
545                 550                 555                 560 


Leu Gln Arg Thr Ser Ser Tyr Ser Thr Asp Gly Leu Gly Leu Gly Gly 
                565                 570                 575     


Glu Ser Leu Glu Lys Ser Gly Tyr Leu Leu Lys Met Gly Ser Gln Val 
            580                 585                 590         


Lys Thr Trp Lys Arg Arg Trp Phe Val Leu Arg Gln Gly Gln Ile Met 
        595                 600                 605             


Tyr Tyr Lys Ser Pro Ser Asp Val Ile Arg Lys Pro Gln Gly Gln Val 
    610                 615                 620                 


Asp Leu Asn Ser Arg Cys Gln Ile Val Arg Gly Glu Gly Ser Gln Thr 
625                 630                 635                 640 


Phe Gln Leu Ile Ser Glu Lys Lys Thr Tyr Tyr Leu Thr Ala Asp Ser 
                645                 650                 655     


Pro Ser Leu Leu Glu Glu Trp Ile Arg Val Leu Gln Ser Leu Leu Lys 
            660                 665                 670         


Val Gln Ala Thr Gly Pro Pro Ala Leu Leu Arg Gly Gly Thr Lys Pro 
        675                 680                 685             


Thr Val Lys Gly Trp Leu Thr Lys Val Lys His Gly His Ser Lys Val 
    690                 695                 700                 


Val Trp Cys Ala Leu Val Gly Lys Ile Phe Tyr Tyr Tyr Arg Ser His 
705                 710                 715                 720 


Glu Asp Lys Arg Pro Leu Gly Cys Leu Pro Val Arg Asp Ala His Ile 
                725                 730                 735     


Glu Glu Val Asp Arg Ser Cys Asp Ser Asp Glu Asp Tyr Glu Ala Gly 
            740                 745                 750         


Gly Thr Arg Arg Leu Leu Ser Ser His Cys Thr Leu Val Ile His Pro 
        755                 760                 765             


Thr Glu His Ser Pro Thr Tyr Leu Leu Ile Gly Thr Lys His Glu Lys 
    770                 775                 780                 


Asp Thr Trp Leu Tyr His Leu Thr Val Ala Ala Gly Gly Ser Ser Ala 
785                 790                 795                 800 


Lys Val Gly Thr Ala Tyr Glu Gln Leu Ile Gly Lys Leu Met Asp Gly 
                805                 810                 815     


Glu Gly Asp Pro Asp Ser Pro Leu Trp Arg His Pro Met Leu Cys Tyr 
            820                 825                 830         


Ser Lys Asp Gly Leu Tyr Ala Ser Leu Thr Thr Leu Pro Ser Glu Ala 
        835                 840                 845             


Leu Gln Thr Glu Ala Leu Lys Leu Phe Lys Ser Cys Gln Leu Phe Ile 
    850                 855                 860                 


Asn Val Pro Val Glu Ala Ala Ser Val Asp Tyr His Val Ser Leu Ala 
865                 870                 875                 880 


Gln Thr Ala Leu Gln Val Cys Leu Val His Pro Glu Leu Gln Ser Glu 
                885                 890                 895     


Ile Tyr Cys Gln Leu Met Lys Gln Thr Ser Cys Arg Pro Pro Gln Lys 
            900                 905                 910         


Tyr Ser Leu Met Gln Cys Trp Gln Leu Leu Ala Leu Cys Ala Pro Leu 
        915                 920                 925             


Phe Leu Pro Gln His His Phe Leu Trp Tyr Val Lys Gln Gln Leu Gln 
    930                 935                 940                 


Arg His Ala Asp Pro Arg Ser Glu Thr Gly Gln Tyr Ala Thr Tyr Cys 
945                 950                 955                 960 


Gln Arg Ala Val Glu Arg Thr Leu Arg Thr Gly Glu Arg Glu Ala Arg 
                965                 970                 975     


Pro Ser Arg Met Glu Val Val Ser Ile Leu Leu Arg Asn Pro Phe His 
            980                 985                 990         


His Ser Leu Pro Phe Ser Ile Pro  Val His Phe Thr Asn  Gly Thr Tyr 
        995                 1000                 1005             


His Val  Val Gly Phe Asp Gly  Ser Ser Thr Val Asp  Glu Phe Leu 
    1010                 1015                 1020             


Gln Arg  Leu Asn Gln Glu Ile  Gly Met Arg Lys Pro  Ser His Ser 
    1025                 1030                 1035             


Gly Phe  Ala Leu Phe Thr Asp  Asp Pro Ser Gly Arg  Asp Leu Glu 
    1040                 1045                 1050             


His Cys  Leu Gln Gly Ser Val  Lys Ile Cys Asp Ala  Ile Ser Lys 
    1055                 1060                 1065             


Trp Glu  Gln Ala Met Lys Glu  Leu His Pro Gly Lys  Ser Glu Gly 
    1070                 1075                 1080             


Gly Thr  Arg Val Val Lys Leu  Met Tyr Lys Asn Arg  Leu Tyr Phe 
    1085                 1090                 1095             


Arg Ser  Gln Val Lys Gly Glu  Thr Asp Arg Glu Arg  Leu Leu Leu 
    1100                 1105                 1110             


Ala Ser  Gln Thr Ser Arg Glu  Ile Val Ala Gly Arg  Phe Pro Ile 
    1115                 1120                 1125             


Asn Lys  Glu Leu Ala Leu Glu  Met Ala Ala Leu Met  Ala Gln Val 
    1130                 1135                 1140             


Glu Tyr  Gly Asp Leu Glu Lys  Pro Ala Leu Pro Gly  Pro Gly Gly 
    1145                 1150                 1155             


Thr Ser  Pro Ala Lys Ala Gln  His Leu Leu Gln Gln  Val Leu Asp 
    1160                 1165                 1170             


Arg Phe  His Pro Arg Arg Tyr  Arg His Gly Ala Pro  Ala Glu Gln 
    1175                 1180                 1185             


Leu Arg  His Leu Ala Asp Met  Leu Thr Thr Lys Trp  Ala Thr Leu 
    1190                 1195                 1200             


Gln Gly  Cys Ser Pro Pro Glu  Cys Ile Arg Ile Tyr  Leu Thr Val 
    1205                 1210                 1215             


Ala Arg  Lys Trp Pro Phe Phe  Gly Ala Lys Leu Phe  Ala Ala Gln 
    1220                 1225                 1230             


Pro Ala  Gln Leu Ser Ser Lys  Glu Asn Ala Leu Val  Trp Ile Ala 
    1235                 1240                 1245             


Val Asn  Glu Asp Gly Val Ser  Ile Leu Asp His Asn  Thr Met Gln 
    1250                 1255                 1260             


Val His  Ile Thr Tyr Pro Tyr  Ser Ser Val Thr Thr  Phe Gly Gly 
    1265                 1270                 1275             


Cys Arg  Asp Asp Phe Met Leu  Val Ile Arg Ser Ile  Pro Asp Lys 
    1280                 1285                 1290             


Ser Ser  Gly Lys Ser His Ile  Glu Lys Leu Ile Phe  Arg Met Ala 
    1295                 1300                 1305             


Ala Pro  Lys Ile Ala Glu Ala  Thr Phe Ile Met Ala  Ser Tyr Met 
    1310                 1315                 1320             


Asn His  Cys Thr Thr Thr Val  Asn Pro Pro Thr Asn  Pro Pro Gly 
    1325                 1330                 1335             


Ala Cys  Gln Leu Trp Glu Leu  Asp Gly Arg Gln Phe  Phe Ser Ser 
    1340                 1345                 1350             


Val Ser  Cys Ala Thr Lys Gly  Pro Thr Leu Leu 
    1355                 1360                 


<210>  765
<211>  6789
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (431)..(2713)

<400>  765
tcccagccgg cctccggggc cctccgggct gaaatcgaca tttgcctctg gcaggaaaat       60

gagcttgtca gtttctgcct ccattagacc ctcaacccaa aggagcagga gatttcggta      120

gcgttttaac tttatctcag aatctgaaag cggaaggcca ggcaagctgc acacatcaag      180

cgaaacgcct gaggggcggc cagcgcgagg gtttctggcc atcgaccctc acctcccggg      240

acttccaggg tcttcccccc accccgcgca cacctccctg cctcgccccg agggcgtcac      300

gtggcagcgt ggggcccgcc tcctggtgat gtcacggcgc tcgcagccgt cgcgctgaag      360

aaaggatgct cgaggatgct gtccaggtgg gcggccgcgg gcgcgatgcg gcactgcagg      420

tgtaattagc atg gtc aat gcg gga gcg atg agt ggc tct gga aac ctg         469
           Met Val Asn Ala Gly Ala Met Ser Gly Ser Gly Asn Leu            
           1               5                   10                         

atg gat ttc ctc gat gag ccg ttc cct gat gtg ggg acg tat gag gac        517
Met Asp Phe Leu Asp Glu Pro Phe Pro Asp Val Gly Thr Tyr Glu Asp           
    15                  20                  25                            

ttc cac acc atc gac tgg cta agg gaa aag tca cgg gac acc gac aga        565
Phe His Thr Ile Asp Trp Leu Arg Glu Lys Ser Arg Asp Thr Asp Arg           
30                  35                  40                  45            

cac agg aag atc acc agc aag agc aag gag tcc ata tgg gag ttc atc        613
His Arg Lys Ile Thr Ser Lys Ser Lys Glu Ser Ile Trp Glu Phe Ile           
                50                  55                  60                

aag agc ctg ctg gat gcc tgg tcg gga tgg gtg gtg atg ctg ctc atc        661
Lys Ser Leu Leu Asp Ala Trp Ser Gly Trp Val Val Met Leu Leu Ile           
            65                  70                  75                    

ggc ctg ctg gcg ggc acc ttg gct ggg gtc atc gat ctc gcc gtg gac        709
Gly Leu Leu Ala Gly Thr Leu Ala Gly Val Ile Asp Leu Ala Val Asp           
        80                  85                  90                        

tgg atg acg gac ctg aag gag ggg gtc tgc ctg tct gcc ttc tgg tat        757
Trp Met Thr Asp Leu Lys Glu Gly Val Cys Leu Ser Ala Phe Trp Tyr           
    95                  100                 105                           

agc cat gag cag tgt tgc tgg act tct aac gag acc act ttt gag gac        805
Ser His Glu Gln Cys Cys Trp Thr Ser Asn Glu Thr Thr Phe Glu Asp           
110                 115                 120                 125           

aga gac aag tgt ccc ctg tgg cag aaa tgg tcg gag ctg ctg gtg aat        853
Arg Asp Lys Cys Pro Leu Trp Gln Lys Trp Ser Glu Leu Leu Val Asn           
                130                 135                 140               

cag tca gag ggt gcc agt gct tac att ctg aat tac tta atg tac atc        901
Gln Ser Glu Gly Ala Ser Ala Tyr Ile Leu Asn Tyr Leu Met Tyr Ile           
            145                 150                 155                   

cta tgg gcg ctg ctg ttt gca ttt ttg gct gtc tcc ctg gtg cgt gta        949
Leu Trp Ala Leu Leu Phe Ala Phe Leu Ala Val Ser Leu Val Arg Val           
        160                 165                 170                       

ttt gca cca tat gcc tgt ggc tct ggc ata cca gag ata aag acc att        997
Phe Ala Pro Tyr Ala Cys Gly Ser Gly Ile Pro Glu Ile Lys Thr Ile           
    175                 180                 185                           

ttg agc ggc ttt atc atc agg ggc tac ttg ggg aag tgg acc ctg cta       1045
Leu Ser Gly Phe Ile Ile Arg Gly Tyr Leu Gly Lys Trp Thr Leu Leu           
190                 195                 200                 205           

atc aag aca gtc acg ctg gtg ctg gta gtg tcc tcc ggt ctg agc ctt       1093
Ile Lys Thr Val Thr Leu Val Leu Val Val Ser Ser Gly Leu Ser Leu           
                210                 215                 220               

ggg aag gaa ggg ccg cta gtg cac gtg gct tgt tgc tgt ggc aac ttc       1141
Gly Lys Glu Gly Pro Leu Val His Val Ala Cys Cys Cys Gly Asn Phe           
            225                 230                 235                   

ttc agc agc ctt ttc tcc aag tac agc aag aat gag ggc aag agg cgg       1189
Phe Ser Ser Leu Phe Ser Lys Tyr Ser Lys Asn Glu Gly Lys Arg Arg           
        240                 245                 250                       

gag gtg ctt tca gct gca gcg gct gct gga gtc tct gtt gcc ttt ggt       1237
Glu Val Leu Ser Ala Ala Ala Ala Ala Gly Val Ser Val Ala Phe Gly           
    255                 260                 265                           

gca cca att gga ggc gtg ctt ttc agt cta gaa gag gtc agt tac tac       1285
Ala Pro Ile Gly Gly Val Leu Phe Ser Leu Glu Glu Val Ser Tyr Tyr           
270                 275                 280                 285           

ttt ccc ctg aag acc ttg tgg agg tca ttt ttc gca gcc ctg gtg gcg       1333
Phe Pro Leu Lys Thr Leu Trp Arg Ser Phe Phe Ala Ala Leu Val Ala           
                290                 295                 300               

gcc ttt acg ctg aga tcc atc aat ccc ttt ggg aat agc cgt ctc gtt       1381
Ala Phe Thr Leu Arg Ser Ile Asn Pro Phe Gly Asn Ser Arg Leu Val           
            305                 310                 315                   

ctc ttt tat gtg gaa tac cac acg ccc tgg tac atg gct gaa ctc ttc       1429
Leu Phe Tyr Val Glu Tyr His Thr Pro Trp Tyr Met Ala Glu Leu Phe           
        320                 325                 330                       

ccc ttc atc ctg ctt ggg gtc ttc ggg ggc ttg tgg gga acc ctc ttc       1477
Pro Phe Ile Leu Leu Gly Val Phe Gly Gly Leu Trp Gly Thr Leu Phe           
    335                 340                 345                           

atc cgc tgc aac atc gcc tgg tgc agg agg cgc aag acc acc agg ctg       1525
Ile Arg Cys Asn Ile Ala Trp Cys Arg Arg Arg Lys Thr Thr Arg Leu           
350                 355                 360                 365           

ggg aag tac ccg gtg ctg gag gtc att gtg gtg act gcc atc act gcc       1573
Gly Lys Tyr Pro Val Leu Glu Val Ile Val Val Thr Ala Ile Thr Ala           
                370                 375                 380               

atc att gcc tac ccc aat ccc tac aca cgc cag agc acc agc gag ctc       1621
Ile Ile Ala Tyr Pro Asn Pro Tyr Thr Arg Gln Ser Thr Ser Glu Leu           
            385                 390                 395                   

att tct gag ctg ttc aat gac tgt gga gcc ctt gag tct tcc cag ctc       1669
Ile Ser Glu Leu Phe Asn Asp Cys Gly Ala Leu Glu Ser Ser Gln Leu           
        400                 405                 410                       

tgt gac tac atc aat gac ccc aac atg act cgg cct gtg gat gac att       1717
Cys Asp Tyr Ile Asn Asp Pro Asn Met Thr Arg Pro Val Asp Asp Ile           
    415                 420                 425                           

cca gac cgg ccg gct ggt gtc ggt gtt tac acg gcc atg tgg cag ctg       1765
Pro Asp Arg Pro Ala Gly Val Gly Val Tyr Thr Ala Met Trp Gln Leu           
430                 435                 440                 445           

gcc ctg gca ctg atc ttc aaa atc gtc gtt acc ata ttt acc ttt ggc       1813
Ala Leu Ala Leu Ile Phe Lys Ile Val Val Thr Ile Phe Thr Phe Gly           
                450                 455                 460               

atg aag atc ccg tcg ggc ctc ttc atc ccc agc atg gct gtg ggc gcg       1861
Met Lys Ile Pro Ser Gly Leu Phe Ile Pro Ser Met Ala Val Gly Ala           
            465                 470                 475                   

ata gcg ggc agg atg gtg gga att ggc gtg gag cag ctg gcc tac cat       1909
Ile Ala Gly Arg Met Val Gly Ile Gly Val Glu Gln Leu Ala Tyr His           
        480                 485                 490                       

cac cat gac tgg atc atc ttc agg aac tgg tgc aga ccc ggt gca gac       1957
His His Asp Trp Ile Ile Phe Arg Asn Trp Cys Arg Pro Gly Ala Asp           
    495                 500                 505                           

tgt gtc acg cca ggg ctg tac gca atg gtg gga gct gcg gcc tgc ctc       2005
Cys Val Thr Pro Gly Leu Tyr Ala Met Val Gly Ala Ala Ala Cys Leu           
510                 515                 520                 525           

ggt gga gtt acc agg atg acg gtg tca ttg gtg gtc atc atg ttt gaa       2053
Gly Gly Val Thr Arg Met Thr Val Ser Leu Val Val Ile Met Phe Glu           
                530                 535                 540               

tta acc ggg ggt ctg gag tac atc gtg ccc ctg atg gcg gcg gct gtg       2101
Leu Thr Gly Gly Leu Glu Tyr Ile Val Pro Leu Met Ala Ala Ala Val           
            545                 550                 555                   

acc agc aag tgg gta gct gat gca ttt ggg aaa gaa ggc atc tac gag       2149
Thr Ser Lys Trp Val Ala Asp Ala Phe Gly Lys Glu Gly Ile Tyr Glu           
        560                 565                 570                       

gcc cac atc cac tta aat ggg tac cct ttc ctt gac gtg aag gac gag       2197
Ala His Ile His Leu Asn Gly Tyr Pro Phe Leu Asp Val Lys Asp Glu           
    575                 580                 585                           

ttt act cac cgc aca ctg gcc acc gac gtc atg cgg ccc cgg cgg gga       2245
Phe Thr His Arg Thr Leu Ala Thr Asp Val Met Arg Pro Arg Arg Gly           
590                 595                 600                 605           

gag ccg cca ctg tcg gtg ctc acc cag gac agc atg act gtc gag gac       2293
Glu Pro Pro Leu Ser Val Leu Thr Gln Asp Ser Met Thr Val Glu Asp           
                610                 615                 620               

gtg gag acg ctc atc aag gag acc gac tac aac ggc ttc ccc gtg gtg       2341
Val Glu Thr Leu Ile Lys Glu Thr Asp Tyr Asn Gly Phe Pro Val Val           
            625                 630                 635                   

gtc tcc aga gac tcc gag cgc ctc att gga ttt gcc cag agg agg gaa       2389
Val Ser Arg Asp Ser Glu Arg Leu Ile Gly Phe Ala Gln Arg Arg Glu           
        640                 645                 650                       

ctg att ctc gca ata aag aac gcc aga cag agg cag gag ggc att gtg       2437
Leu Ile Leu Ala Ile Lys Asn Ala Arg Gln Arg Gln Glu Gly Ile Val           
    655                 660                 665                           

agc aat tcc atc atg tac ttc acg gag gaa ccc ccc gag ctg ccg gcc       2485
Ser Asn Ser Ile Met Tyr Phe Thr Glu Glu Pro Pro Glu Leu Pro Ala           
670                 675                 680                 685           

aac agc cca cat ccc ctg aag ctg cgg cgc atc ctg aac ctc agc ccg       2533
Asn Ser Pro His Pro Leu Lys Leu Arg Arg Ile Leu Asn Leu Ser Pro           
                690                 695                 700               

ttt aca gtg aca gac cac act ccg atg gaa acg gtg gtg gat atc ttc       2581
Phe Thr Val Thr Asp His Thr Pro Met Glu Thr Val Val Asp Ile Phe           
            705                 710                 715                   

cgg aaa ctg ggg ctt cgg cag tgc ctg gtg acg cgg agc ggg aga ctt       2629
Arg Lys Leu Gly Leu Arg Gln Cys Leu Val Thr Arg Ser Gly Arg Leu           
        720                 725                 730                       

ctt ggc atc atc aca aaa aag gat gtt ctg aga cat atg gcc cag atg       2677
Leu Gly Ile Ile Thr Lys Lys Asp Val Leu Arg His Met Ala Gln Met           
    735                 740                 745                           

gca aac cag gac ccc gaa tcc atc atg ttt aat tag caacaaggtg            2723
Ala Asn Gln Asp Pro Glu Ser Ile Met Phe Asn                               
750                 755                 760                               

gcaattattt tcagaaaaac actgactgtg tcatttaaaa agaaataaat gatatgttat     2783

tatcccaatg aaagatcatg cattggggac agcagaaaca aaagcttttt tggaaaggcg     2843

gggaagaagg atgaaacctt taaaaacaaa aacaaaaaca tcaatgagta ggcattttat     2903

agctttaacc ccgtatgagt ttcaagctgt gtttcctaat gagtttgcta ctgctgtggg     2963

ggcatgtggg tgggtaaatg atgtaaatga tgtgatctgt acaagtatgt ggagcatgaa     3023

tgctgactca agaaactttt actccttctg ctcaaggctg atgtttgtaa cttatgaaca     3083

cacgtgaagt gttgagtcca aaagacaaag gggcatcggc atgtcagcgt ccttatttat     3143

tggttcttga agttttgctg ctatgttact gaatcatact aaagacattt gcgcttactt     3203

tgttgaaaaa gaaaaagaaa ttaaatttga acacagtgaa agctgcaagt atgccagtgg     3263

gtccgctcac gaccgtcctg tttcttgctc ctgttctcag cctgttatct ggcttatcca     3323

tcagtttctg aaccaacatc aggggcacct gccatgatga gtgtgaagaa atcatttctc     3383

tatgcaagac tggcatcctg ggactgcacg atgaactatt ggagcataca gtactgcggt     3443

gtgtctcctc ccatacaaag ggacacatcc ttattttgag ggtatactca cccgatcatt     3503

gatttgcatc cccatggcat ttgcttcatt tatttattgc ttttgcccat gcattcaata     3563

ttgatcagct cagcacttcc atgggccata gccggtatgc ccccagcctg ccataagcgt     3623

gctttcattt tcaagtagca tatgcaagag tccaaacagg ctacccaatg ttactactta     3683

tttttcctct caggtcttat cagatacggc tgtggagagg atgaggcata tgcgttgtca     3743

gttggaatcc ctccaaatgg attgcaagag aaatactaaa ttgattctaa atctgttcca     3803

ttatcttctc tgtaggatgc aaaacatcca gttgtaatgt ataagcatgc acttcatact     3863

agcaatcaca gcacaggagg acagcattaa attttatata gccaatttgg gcactgggca     3923

tctttgtatt tgaacttaac gacacattta ctcttttagt caggatttcg gtcttttctg     3983

cgggaaggaa ttaagctatg tattaggtcc accatacgat ctgtgtaagt aagattatcc     4043

cacttgccct ttctctttag tctttgtccc ttccttttca ctaagtgccc ctcatccttt     4103

tcaatctcat tgtcactgga tagtgctgta tcacttaggt gtgcattcgg ctgcaaataa     4163

cagaaaaccc agcaaacact gaagggctgg ataagaaccc tgagaggggg tactccagga     4223

ctgtctccat aacatcattg ggatccccat cccgttgcta tttctttttc accgttttta     4283

ccttttgtcc tctggcttat tgcctcagag ttgcaagatg gttcctgaac tgtcaggtat     4343

catgtctgct ttctaagtgg gaagaggaag ggagaggcaa gcaactaggt acaatgtcta     4403

tcaggaaagc aaagcttccc cagagacgct cagcttgtat ccattgactg gaagtctgtc     4463

acgtggctcc ccctagccgc acactagtgt gggaaggaaa atattgagct aggcacatta     4523

ctctctgaac gaaattcata ttatcttatt aaggaagagt gttggtcttc aggaggggaa     4583

gtttgctgta ttggatgcca tcatcgtgtc cttgtcattg cccttccggt tttcattctt     4643

gctaaacccc tgtgaatgtt cttctaacct tcctgttccc cacccctttt ctcagatttg     4703

acctagaatt cccagcccaa atccataatt tcttagctct aatacgaatt ttcatgttgg     4763

acaaaaacct agctacaaat gggtttctat ggaacttcta attaatgtgc aaaatacata     4823

ttttctccag gttaagaaat tttaagtcag atcatgctga cacaataaga aaatttgttt     4883

gtgtaattca ttgacctctt ccttccaaaa taacatcaag tagccacctc agtgtgacaa     4943

tatccagtca atagtagaga atttaatcct tggtcctata aaagaataaa attcattgtc     5003

gtatttatag cacgtaagcc ttgagtaaca ggtcttaatg ttagtgttgg tgttgtggtt     5063

tctgcggaac gtttacaagt gaagttggat tctcctgggc tttaaatcca aaaagtctta     5123

atgaccgctt catgtagttc ccctcttatt cccctgtggt ctcctcagag ccagcgtgtg     5183

ctgggaaaga gtattagtca tagcctggct ttatagaatc caggaggtcc ttttagctga     5243

aacaagtggc ttcaaaaggg aacatgaaac agtgaaaaga tagccaaagg tcagtgaaac     5303

cacagcattt ctttctaatc tggctgaggc catggggggg aatgagggga aattatgctt     5363

ccgggccaag gtcaccgagg gggaccttgg gatttgtgtc ctccccagtg cttagagtag     5423

agatacctgc aaattcatgg caaacagttg gaagagttac ttgactgaaa caacccaatc     5483

ttactttctt tcgtaagttg aacctctgat ttattgtggg gttcaggctc tcctcaatag     5543

aaggccagag ttggacaggt ggactaaggt caaggatgag gagtctgcag tggggactac     5603

cacagcaaac tgccttcctt ccgtggagtc ctaactcagc catgtggtcc actcacccag     5663

gggcccgggg gctcagacaa accccatggg gaacatgctg ccatgctctg tctttcttgt     5723

aaacgtagtt gggtagggat cccaagggta tttgctctct ccaaatgcag aacttccatc     5783

cactttatct ggtgatctga tgaacagcat ggggacgtgg aggtgaaata agcatctttc     5843

agaataaggt tttttttttt ttcctcttcc agaaccaaag gctttagaca tttgtagaac     5903

tttctggatt ccttctgaat cgggttttaa cataaaaaac catcaacaca tcatgggaaa     5963

ggagctcttt catgatatac atcacatgtt tcttgctctc actgaggaaa tgtgttgtac     6023

aaaagcacca aataagggca ccctggaagt gacatgtgtg tttcttctaa gtcgttttta     6083

gtgcatcccc tgcgattgca tgatgctcat gtggctttta gggaaaggca gaatgtgcta     6143

gaagtcgaag tcattcaata ttcagtgctt actgttactt tgaaccaggt aatctcagtt     6203

ctttattcag tccttcccaa agaccttaca aaggagatgt gtaaactgat agattttgag     6263

cctaataagt cacagaaatg gaaaatttta gagcagtttg tttcacttag gtgagaactg     6323

attactttaa attaccaaca tgtgcaaatt ctacttagta ttcattatta gatgctaagc     6383

tggaaaagat gagaaaccca aggagaacta ttgaattacc acataattgt aatattatgc     6443

tttaattttg tatgggcagt gttctatcag actaagcttc tagcctttga aatgatttac     6503

atgaggagag agcctgtata tctgacttgg gaaacattaa gcagacccta ttttcactgg     6563

cgcggtaata actatttatt tgctatccta gaggtgctgg gaatgagcct acgtgcgact     6623

ttgatgagat atattcacat ttggtgttgg aacgaccaca tagcaacgtg ttggtttttt     6683

tttattgtaa cactctgtgt aaacgttgac accttattaa atattaaatg tctgaactct     6743

atttttaaaa ataaaacaag cacagagtct gcaacaaaca tgtaaa                    6789


<210>  766
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  766

Met Val Asn Ala Gly Ala Met Ser Gly Ser Gly Asn Leu Met Asp Phe 
1               5                   10                  15      


Leu Asp Glu Pro Phe Pro Asp Val Gly Thr Tyr Glu Asp Phe His Thr 
            20                  25                  30          


Ile Asp Trp Leu Arg Glu Lys Ser Arg Asp Thr Asp Arg His Arg Lys 
        35                  40                  45              


Ile Thr Ser Lys Ser Lys Glu Ser Ile Trp Glu Phe Ile Lys Ser Leu 
    50                  55                  60                  


Leu Asp Ala Trp Ser Gly Trp Val Val Met Leu Leu Ile Gly Leu Leu 
65                  70                  75                  80  


Ala Gly Thr Leu Ala Gly Val Ile Asp Leu Ala Val Asp Trp Met Thr 
                85                  90                  95      


Asp Leu Lys Glu Gly Val Cys Leu Ser Ala Phe Trp Tyr Ser His Glu 
            100                 105                 110         


Gln Cys Cys Trp Thr Ser Asn Glu Thr Thr Phe Glu Asp Arg Asp Lys 
        115                 120                 125             


Cys Pro Leu Trp Gln Lys Trp Ser Glu Leu Leu Val Asn Gln Ser Glu 
    130                 135                 140                 


Gly Ala Ser Ala Tyr Ile Leu Asn Tyr Leu Met Tyr Ile Leu Trp Ala 
145                 150                 155                 160 


Leu Leu Phe Ala Phe Leu Ala Val Ser Leu Val Arg Val Phe Ala Pro 
                165                 170                 175     


Tyr Ala Cys Gly Ser Gly Ile Pro Glu Ile Lys Thr Ile Leu Ser Gly 
            180                 185                 190         


Phe Ile Ile Arg Gly Tyr Leu Gly Lys Trp Thr Leu Leu Ile Lys Thr 
        195                 200                 205             


Val Thr Leu Val Leu Val Val Ser Ser Gly Leu Ser Leu Gly Lys Glu 
    210                 215                 220                 


Gly Pro Leu Val His Val Ala Cys Cys Cys Gly Asn Phe Phe Ser Ser 
225                 230                 235                 240 


Leu Phe Ser Lys Tyr Ser Lys Asn Glu Gly Lys Arg Arg Glu Val Leu 
                245                 250                 255     


Ser Ala Ala Ala Ala Ala Gly Val Ser Val Ala Phe Gly Ala Pro Ile 
            260                 265                 270         


Gly Gly Val Leu Phe Ser Leu Glu Glu Val Ser Tyr Tyr Phe Pro Leu 
        275                 280                 285             


Lys Thr Leu Trp Arg Ser Phe Phe Ala Ala Leu Val Ala Ala Phe Thr 
    290                 295                 300                 


Leu Arg Ser Ile Asn Pro Phe Gly Asn Ser Arg Leu Val Leu Phe Tyr 
305                 310                 315                 320 


Val Glu Tyr His Thr Pro Trp Tyr Met Ala Glu Leu Phe Pro Phe Ile 
                325                 330                 335     


Leu Leu Gly Val Phe Gly Gly Leu Trp Gly Thr Leu Phe Ile Arg Cys 
            340                 345                 350         


Asn Ile Ala Trp Cys Arg Arg Arg Lys Thr Thr Arg Leu Gly Lys Tyr 
        355                 360                 365             


Pro Val Leu Glu Val Ile Val Val Thr Ala Ile Thr Ala Ile Ile Ala 
    370                 375                 380                 


Tyr Pro Asn Pro Tyr Thr Arg Gln Ser Thr Ser Glu Leu Ile Ser Glu 
385                 390                 395                 400 


Leu Phe Asn Asp Cys Gly Ala Leu Glu Ser Ser Gln Leu Cys Asp Tyr 
                405                 410                 415     


Ile Asn Asp Pro Asn Met Thr Arg Pro Val Asp Asp Ile Pro Asp Arg 
            420                 425                 430         


Pro Ala Gly Val Gly Val Tyr Thr Ala Met Trp Gln Leu Ala Leu Ala 
        435                 440                 445             


Leu Ile Phe Lys Ile Val Val Thr Ile Phe Thr Phe Gly Met Lys Ile 
    450                 455                 460                 


Pro Ser Gly Leu Phe Ile Pro Ser Met Ala Val Gly Ala Ile Ala Gly 
465                 470                 475                 480 


Arg Met Val Gly Ile Gly Val Glu Gln Leu Ala Tyr His His His Asp 
                485                 490                 495     


Trp Ile Ile Phe Arg Asn Trp Cys Arg Pro Gly Ala Asp Cys Val Thr 
            500                 505                 510         


Pro Gly Leu Tyr Ala Met Val Gly Ala Ala Ala Cys Leu Gly Gly Val 
        515                 520                 525             


Thr Arg Met Thr Val Ser Leu Val Val Ile Met Phe Glu Leu Thr Gly 
    530                 535                 540                 


Gly Leu Glu Tyr Ile Val Pro Leu Met Ala Ala Ala Val Thr Ser Lys 
545                 550                 555                 560 


Trp Val Ala Asp Ala Phe Gly Lys Glu Gly Ile Tyr Glu Ala His Ile 
                565                 570                 575     


His Leu Asn Gly Tyr Pro Phe Leu Asp Val Lys Asp Glu Phe Thr His 
            580                 585                 590         


Arg Thr Leu Ala Thr Asp Val Met Arg Pro Arg Arg Gly Glu Pro Pro 
        595                 600                 605             


Leu Ser Val Leu Thr Gln Asp Ser Met Thr Val Glu Asp Val Glu Thr 
    610                 615                 620                 


Leu Ile Lys Glu Thr Asp Tyr Asn Gly Phe Pro Val Val Val Ser Arg 
625                 630                 635                 640 


Asp Ser Glu Arg Leu Ile Gly Phe Ala Gln Arg Arg Glu Leu Ile Leu 
                645                 650                 655     


Ala Ile Lys Asn Ala Arg Gln Arg Gln Glu Gly Ile Val Ser Asn Ser 
            660                 665                 670         


Ile Met Tyr Phe Thr Glu Glu Pro Pro Glu Leu Pro Ala Asn Ser Pro 
        675                 680                 685             


His Pro Leu Lys Leu Arg Arg Ile Leu Asn Leu Ser Pro Phe Thr Val 
    690                 695                 700                 


Thr Asp His Thr Pro Met Glu Thr Val Val Asp Ile Phe Arg Lys Leu 
705                 710                 715                 720 


Gly Leu Arg Gln Cys Leu Val Thr Arg Ser Gly Arg Leu Leu Gly Ile 
                725                 730                 735     


Ile Thr Lys Lys Asp Val Leu Arg His Met Ala Gln Met Ala Asn Gln 
            740                 745                 750         


Asp Pro Glu Ser Ile Met Phe Asn 
        755                 760 


<210>  767
<211>  963
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(963)

<400>  767
atg gat gcc aca gcc tgt aat gaa tca gtg gat ggc tca ccc gtc ttc         48
Met Asp Ala Thr Ala Cys Asn Glu Ser Val Asp Gly Ser Pro Val Phe           
1               5                   10                  15                

tat cta ttg ggc atc ccc tct ctg cca gag acc ttc ttc ctc cct gtg         96
Tyr Leu Leu Gly Ile Pro Ser Leu Pro Glu Thr Phe Phe Leu Pro Val           
            20                  25                  30                    

ttt ttt att ttc ctc ctc ttc tac ctt ctc atc ctg atg ggt aat gcc        144
Phe Phe Ile Phe Leu Leu Phe Tyr Leu Leu Ile Leu Met Gly Asn Ala           
        35                  40                  45                        

ctg atc ctg gtg gcc gtg gtg gca gag ccc agc ctc cac aag ccc atg        192
Leu Ile Leu Val Ala Val Val Ala Glu Pro Ser Leu His Lys Pro Met           
    50                  55                  60                            

tac ttc ttt ctg atc aat ctc tcc acc ttg gac atc ctt ttc acc aca        240
Tyr Phe Phe Leu Ile Asn Leu Ser Thr Leu Asp Ile Leu Phe Thr Thr           
65                  70                  75                  80            

acc act gtc ccc aag atg ctg tcc tta ttc ttg ctt ggg gac cgc ttc        288
Thr Thr Val Pro Lys Met Leu Ser Leu Phe Leu Leu Gly Asp Arg Phe           
                85                  90                  95                

ctc agc ttt tct tcc tgc tta ctg cag atg tac ctc ttc caa agt ttt        336
Leu Ser Phe Ser Ser Cys Leu Leu Gln Met Tyr Leu Phe Gln Ser Phe           
            100                 105                 110                   

aca tgt tca gaa gcc ttc atc ctg gtg gtc atg gcc tat gac cgc tat        384
Thr Cys Ser Glu Ala Phe Ile Leu Val Val Met Ala Tyr Asp Arg Tyr           
        115                 120                 125                       

gtg gct atc tgc cac cca ctg cac tac cct gtc ctc atg aac cca cag        432
Val Ala Ile Cys His Pro Leu His Tyr Pro Val Leu Met Asn Pro Gln           
    130                 135                 140                           

acc aat gct acc ttg gca gcc agt gcc tgg cta act gcc ctc ctc ctg        480
Thr Asn Ala Thr Leu Ala Ala Ser Ala Trp Leu Thr Ala Leu Leu Leu           
145                 150                 155                 160           

ccc atc cca gca gta gta agg acc tcc cag atg gca tat aac agc att        528
Pro Ile Pro Ala Val Val Arg Thr Ser Gln Met Ala Tyr Asn Ser Ile           
                165                 170                 175               

gcc tac atc tac cac tgc ttc tgt gat cat ctg gct gtg gtc cag gcc        576
Ala Tyr Ile Tyr His Cys Phe Cys Asp His Leu Ala Val Val Gln Ala           
            180                 185                 190                   

tcc tgc tct gac acc acc ccc cag acc ctc atg ggc ttc tgc atc gcc        624
Ser Cys Ser Asp Thr Thr Pro Gln Thr Leu Met Gly Phe Cys Ile Ala           
        195                 200                 205                       

atg gtg gtg tcc ttc ctc ccc ctt ctc ctg gtg ctt ctc tcc tat gtc        672
Met Val Val Ser Phe Leu Pro Leu Leu Leu Val Leu Leu Ser Tyr Val           
    210                 215                 220                           

cac atc ctg gcc tca gtg ctt cgc atc agt tcc cta gaa gga cgg gca        720
His Ile Leu Ala Ser Val Leu Arg Ile Ser Ser Leu Glu Gly Arg Ala           
225                 230                 235                 240           

aaa gcc ttc tcc acc tgc agc tcc cac ctt ctg gtc gtg ggc acc tac        768
Lys Ala Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Gly Thr Tyr           
                245                 250                 255               

tac tca tct att gcc ata gcc tac gtg gcc tac agg gct gac ctg ccc        816
Tyr Ser Ser Ile Ala Ile Ala Tyr Val Ala Tyr Arg Ala Asp Leu Pro           
            260                 265                 270                   

ctt gac ttc cat atc atg ggc aat gtg gta tat gcc att ctc aca cca        864
Leu Asp Phe His Ile Met Gly Asn Val Val Tyr Ala Ile Leu Thr Pro           
        275                 280                 285                       

att ctc aac ccc ctc att tac acg ctg aga aac agg gat gta aag gca        912
Ile Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Arg Asp Val Lys Ala           
    290                 295                 300                           

gcc atc acc aaa atc atg tct caa gac cca ggc tgt gac agg agc att        960
Ala Ile Thr Lys Ile Met Ser Gln Asp Pro Gly Cys Asp Arg Ser Ile           
305                 310                 315                 320           

tga                                                                    963


<210>  768
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  768

Met Asp Ala Thr Ala Cys Asn Glu Ser Val Asp Gly Ser Pro Val Phe 
1               5                   10                  15      


Tyr Leu Leu Gly Ile Pro Ser Leu Pro Glu Thr Phe Phe Leu Pro Val 
            20                  25                  30          


Phe Phe Ile Phe Leu Leu Phe Tyr Leu Leu Ile Leu Met Gly Asn Ala 
        35                  40                  45              


Leu Ile Leu Val Ala Val Val Ala Glu Pro Ser Leu His Lys Pro Met 
    50                  55                  60                  


Tyr Phe Phe Leu Ile Asn Leu Ser Thr Leu Asp Ile Leu Phe Thr Thr 
65                  70                  75                  80  


Thr Thr Val Pro Lys Met Leu Ser Leu Phe Leu Leu Gly Asp Arg Phe 
                85                  90                  95      


Leu Ser Phe Ser Ser Cys Leu Leu Gln Met Tyr Leu Phe Gln Ser Phe 
            100                 105                 110         


Thr Cys Ser Glu Ala Phe Ile Leu Val Val Met Ala Tyr Asp Arg Tyr 
        115                 120                 125             


Val Ala Ile Cys His Pro Leu His Tyr Pro Val Leu Met Asn Pro Gln 
    130                 135                 140                 


Thr Asn Ala Thr Leu Ala Ala Ser Ala Trp Leu Thr Ala Leu Leu Leu 
145                 150                 155                 160 


Pro Ile Pro Ala Val Val Arg Thr Ser Gln Met Ala Tyr Asn Ser Ile 
                165                 170                 175     


Ala Tyr Ile Tyr His Cys Phe Cys Asp His Leu Ala Val Val Gln Ala 
            180                 185                 190         


Ser Cys Ser Asp Thr Thr Pro Gln Thr Leu Met Gly Phe Cys Ile Ala 
        195                 200                 205             


Met Val Val Ser Phe Leu Pro Leu Leu Leu Val Leu Leu Ser Tyr Val 
    210                 215                 220                 


His Ile Leu Ala Ser Val Leu Arg Ile Ser Ser Leu Glu Gly Arg Ala 
225                 230                 235                 240 


Lys Ala Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Gly Thr Tyr 
                245                 250                 255     


Tyr Ser Ser Ile Ala Ile Ala Tyr Val Ala Tyr Arg Ala Asp Leu Pro 
            260                 265                 270         


Leu Asp Phe His Ile Met Gly Asn Val Val Tyr Ala Ile Leu Thr Pro 
        275                 280                 285             


Ile Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Arg Asp Val Lys Ala 
    290                 295                 300                 


Ala Ile Thr Lys Ile Met Ser Gln Asp Pro Gly Cys Asp Arg Ser Ile 
305                 310                 315                 320 


<210>  769
<211>  6218
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (52)..(6006)

<400>  769
gttaaatctg tggcctttgc atcgaagcca tgctttcaag atgtaaaacc t atg gag        57
                                                         Met Glu          
                                                         1                

ctg aca cca ggg gcc caa cag caa ggt ata aat tat caa gag ttg act        105
Leu Thr Pro Gly Ala Gln Gln Gln Gly Ile Asn Tyr Gln Glu Leu Thr           
        5                   10                  15                        

tca gga tgg caa gat gtg aaa tca atg atg ttg gta cca gag cca act        153
Ser Gly Trp Gln Asp Val Lys Ser Met Met Leu Val Pro Glu Pro Thr           
    20                  25                  30                            

agg aag ttc cca tca gga cca ctg ttg act agt gtc aga ttt tca aat        201
Arg Lys Phe Pro Ser Gly Pro Leu Leu Thr Ser Val Arg Phe Ser Asn           
35                  40                  45                  50            

ttg tct cca gaa tca cag caa cag gat gtg aaa tct ttg gag ttt act        249
Leu Ser Pro Glu Ser Gln Gln Gln Asp Val Lys Ser Leu Glu Phe Thr           
                55                  60                  65                

gta gag cca aag ttg caa agc gta aaa cat gtg aaa tta tct tca gtg        297
Val Glu Pro Lys Leu Gln Ser Val Lys His Val Lys Leu Ser Ser Val           
            70                  75                  80                    

tct ctg cag caa act ata aaa tct gtg gaa tta gca cca ggg tca ctg        345
Ser Leu Gln Gln Thr Ile Lys Ser Val Glu Leu Ala Pro Gly Ser Leu           
        85                  90                  95                        

cct caa aga gtg aaa tat ggg gag caa act cca aga aca aat tat caa        393
Pro Gln Arg Val Lys Tyr Gly Glu Gln Thr Pro Arg Thr Asn Tyr Gln           
    100                 105                 110                           

atc atg gaa tcc tct gaa cta atc cct aga cca ggg cat cag ttt gca        441
Ile Met Glu Ser Ser Glu Leu Ile Pro Arg Pro Gly His Gln Phe Ala           
115                 120                 125                 130           

aaa tat gca gag atg atc cca cag cca aag tat caa atc cct aaa tct        489
Lys Tyr Ala Glu Met Ile Pro Gln Pro Lys Tyr Gln Ile Pro Lys Ser           
                135                 140                 145               

gca aat ttg att tca ata cca att tat cac gcc aca gaa tct tca gaa        537
Ala Asn Leu Ile Ser Ile Pro Ile Tyr His Ala Thr Glu Ser Ser Glu           
            150                 155                 160                   

atg gca caa gga ttg gca tat aaa ggc ata gat act gta gag aaa tct        585
Met Ala Gln Gly Leu Ala Tyr Lys Gly Ile Asp Thr Val Glu Lys Ser           
        165                 170                 175                       

gtg ggg ttg acc cca aag cta aca ggt aga gct aag gaa tcc tta ggg        633
Val Gly Leu Thr Pro Lys Leu Thr Gly Arg Ala Lys Glu Ser Leu Gly           
    180                 185                 190                           

atg ctg ctg cag cca gat ctt cag gta cca aaa ttt gtt gat ctg act        681
Met Leu Leu Gln Pro Asp Leu Gln Val Pro Lys Phe Val Asp Leu Thr           
195                 200                 205                 210           

cca atg gta agg gat caa ggc tca aaa ttc tta gga tta act cca gag        729
Pro Met Val Arg Asp Gln Gly Ser Lys Phe Leu Gly Leu Thr Pro Glu           
                215                 220                 225               

aaa agc tac caa atc cta gaa act atg gaa ttg ctc tct cag tca cgg        777
Lys Ser Tyr Gln Ile Leu Glu Thr Met Glu Leu Leu Ser Gln Ser Arg           
            230                 235                 240                   

ccc cga gtt aag gat gtg ggg gag tta tat atg aag cca ctg cag caa        825
Pro Arg Val Lys Asp Val Gly Glu Leu Tyr Met Lys Pro Leu Gln Gln           
        245                 250                 255                       

act gtg gaa tat gaa ggg att act ccg gaa ctc aag cat tac ttt aca        873
Thr Val Glu Tyr Glu Gly Ile Thr Pro Glu Leu Lys His Tyr Phe Thr           
    260                 265                 270                           

gaa gct atg ggg ttg acc gct gag gca agg ata caa gca aat gaa ttc        921
Glu Ala Met Gly Leu Thr Ala Glu Ala Arg Ile Gln Ala Asn Glu Phe           
275                 280                 285                 290           

ttt gga atg acc cca aag cca aca agt caa gcc act gga ttt gca gag        969
Phe Gly Met Thr Pro Lys Pro Thr Ser Gln Ala Thr Gly Phe Ala Glu           
                295                 300                 305               

aga tcc cca agg ctc tgt cct caa aac tta gaa tgt gtg gag gtg atc       1017
Arg Ser Pro Arg Leu Cys Pro Gln Asn Leu Glu Cys Val Glu Val Ile           
            310                 315                 320                   

tct gag aaa aga ctg caa ggg gaa gaa tct gtg gta ttg att cca aag       1065
Ser Glu Lys Arg Leu Gln Gly Glu Glu Ser Val Val Leu Ile Pro Lys           
        325                 330                 335                       

tca tta cat cac gtc cca gat tct gct tca ggg atg aca cct ggg tta       1113
Ser Leu His His Val Pro Asp Ser Ala Ser Gly Met Thr Pro Gly Leu           
    340                 345                 350                           

gga cat cga gtt cct gaa tct gtg gag ttg act tct aag tca gga gtg       1161
Gly His Arg Val Pro Glu Ser Val Glu Leu Thr Ser Lys Ser Gly Val           
355                 360                 365                 370           

cag gta gag aaa act ttg caa tta acc ccc aaa cca cag cat cat gtg       1209
Gln Val Glu Lys Thr Leu Gln Leu Thr Pro Lys Pro Gln His His Val           
                375                 380                 385               

gga tct cca ggg ata ata tca ggg tta gga cat caa gtc cca gaa tct       1257
Gly Ser Pro Gly Ile Ile Ser Gly Leu Gly His Gln Val Pro Glu Ser           
            390                 395                 400                   

gta aat ctg acc tgt aag caa tgg cta caa atg gag gaa tct tta gag       1305
Val Asn Leu Thr Cys Lys Gln Trp Leu Gln Met Glu Glu Ser Leu Glu           
        405                 410                 415                       

gtg ccc ctg aag caa aca agt caa gtt ata gga cat gaa gaa tct gta       1353
Val Pro Leu Lys Gln Thr Ser Gln Val Ile Gly His Glu Glu Ser Val           
    420                 425                 430                           

gag ctc acc tct gag gca cgg cag cac agg gag gta tca atg ggg cta       1401
Glu Leu Thr Ser Glu Ala Arg Gln His Arg Glu Val Ser Met Gly Leu           
435                 440                 445                 450           

aca aag tca aag aat caa agt atg aaa tct cca ggg aca acc cca gga       1449
Thr Lys Ser Lys Asn Gln Ser Met Lys Ser Pro Gly Thr Thr Pro Gly           
                455                 460                 465               

cca ctg ggt cga att gta gaa ttt atg agg att agt cca gag cca cta       1497
Pro Leu Gly Arg Ile Val Glu Phe Met Arg Ile Ser Pro Glu Pro Leu           
            470                 475                 480                   

gat caa gtc aca gaa tct gca agg aca cag ctt caa gtt gct caa tct       1545
Asp Gln Val Thr Glu Ser Ala Arg Thr Gln Leu Gln Val Ala Gln Ser           
        485                 490                 495                       

gaa gag gta atc ctc ata gat gtc cca aaa gtt gtt caa tct gtg aaa       1593
Glu Glu Val Ile Leu Ile Asp Val Pro Lys Val Val Gln Ser Val Lys           
    500                 505                 510                           

gtg acc cct gga cca cca ttt caa att gta aag tct gtg acg ata cca       1641
Val Thr Pro Gly Pro Pro Phe Gln Ile Val Lys Ser Val Thr Ile Pro           
515                 520                 525                 530           

agg cca acc cct caa atg gta gaa tat att gag ttg act cca aaa ctg       1689
Arg Pro Thr Pro Gln Met Val Glu Tyr Ile Glu Leu Thr Pro Lys Leu           
                535                 540                 545               

caa tat gtg aga cct tca gag cac cac aca ggg cca tgt ttg caa gat       1737
Gln Tyr Val Arg Pro Ser Glu His His Thr Gly Pro Cys Leu Gln Asp           
            550                 555                 560                   

gtg aaa tct aca aaa tta atc aca aag cca aaa cac cag att ttg gaa       1785
Val Lys Ser Thr Lys Leu Ile Thr Lys Pro Lys His Gln Ile Leu Glu           
        565                 570                 575                       

aca gtg gag ttg aca ggg ttt caa att gta aaa act atg tta atc cca       1833
Thr Val Glu Leu Thr Gly Phe Gln Ile Val Lys Thr Met Leu Ile Pro           
    580                 585                 590                           

ggg cca tcc ctt caa atc gta aaa tct gag gag tta gca cca gga cca       1881
Gly Pro Ser Leu Gln Ile Val Lys Ser Glu Glu Leu Ala Pro Gly Pro           
595                 600                 605                 610           

att cct cag gtt gta gaa cca ata gga gta gcc cta gaa tca gga att       1929
Ile Pro Gln Val Val Glu Pro Ile Gly Val Ala Leu Glu Ser Gly Ile           
                615                 620                 625               

gaa gca ata aat tgt gtg gat tta ctt cca agg cca cat ctt caa gaa       1977
Glu Ala Ile Asn Cys Val Asp Leu Leu Pro Arg Pro His Leu Gln Glu           
            630                 635                 640                   

ctg ata gta cct gca gaa tta act cca agt cca tgt act caa gtg aag       2025
Leu Ile Val Pro Ala Glu Leu Thr Pro Ser Pro Cys Thr Gln Val Lys           
        645                 650                 655                       

tct gca gaa tta acc tca ccg caa aca tct cca ttt gag gaa cat aca       2073
Ser Ala Glu Leu Thr Ser Pro Gln Thr Ser Pro Phe Glu Glu His Thr           
    660                 665                 670                           

ata ttg act cat aaa caa ggg ctt cag gct gtg aaa tct aca gtg ata       2121
Ile Leu Thr His Lys Gln Gly Leu Gln Ala Val Lys Ser Thr Val Ile           
675                 680                 685                 690           

aaa aca gag cct cct aaa gtt atg gaa act gag gat ttg aat cta gga       2169
Lys Thr Glu Pro Pro Lys Val Met Glu Thr Glu Asp Leu Asn Leu Gly           
                695                 700                 705               

cac gtg tgt cag aat agg gac tgt cag aag tta aca tca gaa gag tta       2217
His Val Cys Gln Asn Arg Asp Cys Gln Lys Leu Thr Ser Glu Glu Leu           
            710                 715                 720                   

caa gta ggg act gac ttc tct agg ttc cta caa agc tct tca acc aca       2265
Gln Val Gly Thr Asp Phe Ser Arg Phe Leu Gln Ser Ser Ser Thr Thr           
        725                 730                 735                       

ctc att tca agc tct gtc aga aca gca tct gaa tta gga gga ctt tgg       2313
Leu Ile Ser Ser Ser Val Arg Thr Ala Ser Glu Leu Gly Gly Leu Trp           
    740                 745                 750                           

gat tct ggg ata cag gaa gta tcc aga gct ttg gat ata aaa aac cct       2361
Asp Ser Gly Ile Gln Glu Val Ser Arg Ala Leu Asp Ile Lys Asn Pro           
755                 760                 765                 770           

ggg aca gat att ttg cag cct gaa gag acc tat ata gac cct act atg       2409
Gly Thr Asp Ile Leu Gln Pro Glu Glu Thr Tyr Ile Asp Pro Thr Met           
                775                 780                 785               

ata caa tct tta act ttt cct ttg gcc ctt cat aat caa agc tcc gat       2457
Ile Gln Ser Leu Thr Phe Pro Leu Ala Leu His Asn Gln Ser Ser Asp           
            790                 795                 800                   

aag aca gct aac att gtg gaa aac cca tgt cct gag att cta gga gtg       2505
Lys Thr Ala Asn Ile Val Glu Asn Pro Cys Pro Glu Ile Leu Gly Val           
        805                 810                 815                       

gat gta ata tct aaa gag aca act aag agg aag caa atg gag gag cta       2553
Asp Val Ile Ser Lys Glu Thr Thr Lys Arg Lys Gln Met Glu Glu Leu           
    820                 825                 830                           

gag aac tca ctt cag aga cat cta cca caa agc tgg aga tca cga tct       2601
Glu Asn Ser Leu Gln Arg His Leu Pro Gln Ser Trp Arg Ser Arg Ser           
835                 840                 845                 850           

agg aca ttc cag gca gaa tca ggg gtt cag aaa ggt ctc atc aag tct       2649
Arg Thr Phe Gln Ala Glu Ser Gly Val Gln Lys Gly Leu Ile Lys Ser           
                855                 860                 865               

ttc ccg ggc aga caa cac aat gtc tgg gag agt cat gcc tgg agg cag       2697
Phe Pro Gly Arg Gln His Asn Val Trp Glu Ser His Ala Trp Arg Gln           
            870                 875                 880                   

cga cta cca aga aaa tat ctc tcc act atg cta atg ctg ggg aat att       2745
Arg Leu Pro Arg Lys Tyr Leu Ser Thr Met Leu Met Leu Gly Asn Ile           
        885                 890                 895                       

tta ggg acc act atg gaa agg aag ctt tgt tct caa aca tct tta gca       2793
Leu Gly Thr Thr Met Glu Arg Lys Leu Cys Ser Gln Thr Ser Leu Ala           
    900                 905                 910                           

gaa aga gcc act gca gat acc tgt caa tct att cag aat tta ttt ggg       2841
Glu Arg Ala Thr Ala Asp Thr Cys Gln Ser Ile Gln Asn Leu Phe Gly           
915                 920                 925                 930           

att cca gct gaa ctg atg gaa cct tcc cag agc ctg cca gag aag ggt       2889
Ile Pro Ala Glu Leu Met Glu Pro Ser Gln Ser Leu Pro Glu Lys Gly           
                935                 940                 945               

cca gtt act att tct cag cct tct gtg gtc aaa aac tat att cag aga       2937
Pro Val Thr Ile Ser Gln Pro Ser Val Val Lys Asn Tyr Ile Gln Arg           
            950                 955                 960                   

cat act ttt tat cat ggt cat aag aaa aga atg gcc tta agg ata tgg       2985
His Thr Phe Tyr His Gly His Lys Lys Arg Met Ala Leu Arg Ile Trp           
        965                 970                 975                       

aca cgt ggc tcc aca tct tcc ata ata cag caa tac tct ggg act aga       3033
Thr Arg Gly Ser Thr Ser Ser Ile Ile Gln Gln Tyr Ser Gly Thr Arg           
    980                 985                 990                           

gtg aga ata aag aag aca  aac tca acg ttc aat  ggt ata tcc caa         3078
Val Arg Ile Lys Lys Thr  Asn Ser Thr Phe Asn  Gly Ile Ser Gln             
995                 1000                 1005                             

gaa  gtc att caa cat atg  cct gtc tca tgt gca  ggg ggc cag ctt        3123
Glu  Val Ile Gln His Met  Pro Val Ser Cys Ala  Gly Gly Gln Leu            
1010                 1015                 1020                            

cct  gtc ctg gta aag tca  gag tct tcc ctc agc  ata ttt tac gat        3168
Pro  Val Leu Val Lys Ser  Glu Ser Ser Leu Ser  Ile Phe Tyr Asp            
1025                 1030                 1035                            

aga  gaa gat ctt gtt cca  atg gaa gaa agt gag  gac tca cag agt        3213
Arg  Glu Asp Leu Val Pro  Met Glu Glu Ser Glu  Asp Ser Gln Ser            
1040                 1045                 1050                            

gat  tcc cag aca agg att  tct gag tcc caa cac  tcc ctc aag cca        3258
Asp  Ser Gln Thr Arg Ile  Ser Glu Ser Gln His  Ser Leu Lys Pro            
1055                 1060                 1065                            

aat  tat ctt tcc cag gcc  aag act gac ttc tca  gaa cag ttc cag        3303
Asn  Tyr Leu Ser Gln Ala  Lys Thr Asp Phe Ser  Glu Gln Phe Gln            
1070                 1075                 1080                            

ttg  cta gaa gat ctg cag  cta aaa ata gca gca  aaa ctc tta agg        3348
Leu  Leu Glu Asp Leu Gln  Leu Lys Ile Ala Ala  Lys Leu Leu Arg            
1085                 1090                 1095                            

agt  caa ata ccc ccc gat  gtg cct cca cct cta  gct tca ggt cta        3393
Ser  Gln Ile Pro Pro Asp  Val Pro Pro Pro Leu  Ala Ser Gly Leu            
1100                 1105                 1110                            

gtc  cta aaa tac cct atc  tgc cta cag tgt ggc  cga tgt tca gga        3438
Val  Leu Lys Tyr Pro Ile  Cys Leu Gln Cys Gly  Arg Cys Ser Gly            
1115                 1120                 1125                            

ctt  aat tgc cat cat aaa  tta cag acc act tcg  ggg cct tat ctt        3483
Leu  Asn Cys His His Lys  Leu Gln Thr Thr Ser  Gly Pro Tyr Leu            
1130                 1135                 1140                            

ctt  atc tat cca cag ctc  cac ctt gta cgc act  cct gaa ggc cat        3528
Leu  Ile Tyr Pro Gln Leu  His Leu Val Arg Thr  Pro Glu Gly His            
1145                 1150                 1155                            

ggt  gag gtt cgg ttg cat  ctt ggc ttt agg ctg  aga att ggg aaa        3573
Gly  Glu Val Arg Leu His  Leu Gly Phe Arg Leu  Arg Ile Gly Lys            
1160                 1165                 1170                            

aga  tcc caa atc tca aag  tat cgt gaa aga gat  aga ccc gtc ata        3618
Arg  Ser Gln Ile Ser Lys  Tyr Arg Glu Arg Asp  Arg Pro Val Ile            
1175                 1180                 1185                            

cgg  aga agc cct ata tca  cca tca caa agg aaa  gct aaa atc tat        3663
Arg  Arg Ser Pro Ile Ser  Pro Ser Gln Arg Lys  Ala Lys Ile Tyr            
1190                 1195                 1200                            

act  caa gct tcc aag agt  cct act tcc aca ata  gat ttg cag tct        3708
Thr  Gln Ala Ser Lys Ser  Pro Thr Ser Thr Ile  Asp Leu Gln Ser            
1205                 1210                 1215                            

ggg  cct tcc cag tcc cct  gct cct gta caa gtc  tac atc agg cga        3753
Gly  Pro Ser Gln Ser Pro  Ala Pro Val Gln Val  Tyr Ile Arg Arg            
1220                 1225                 1230                            

gga  caa cgc agc agg cct  gac tta gta gaa aag  aca aaa act aga        3798
Gly  Gln Arg Ser Arg Pro  Asp Leu Val Glu Lys  Thr Lys Thr Arg            
1235                 1240                 1245                            

gca  cct ggg cac tat gaa  ttc act caa gtt cac  aac cta cca gag        3843
Ala  Pro Gly His Tyr Glu  Phe Thr Gln Val His  Asn Leu Pro Glu            
1250                 1255                 1260                            

agt  gac tct gaa agc act  cag aat gaa aaa cgg  gct aaa gtg aga        3888
Ser  Asp Ser Glu Ser Thr  Gln Asn Glu Lys Arg  Ala Lys Val Arg            
1265                 1270                 1275                            

acc  aaa aag acc tct gat  tca aaa tat cca atg  aag aga atc acc        3933
Thr  Lys Lys Thr Ser Asp  Ser Lys Tyr Pro Met  Lys Arg Ile Thr            
1280                 1285                 1290                            

aag  cga ctt aga aaa cac  aga aag ttc tac aca  aac agt aga acc        3978
Lys  Arg Leu Arg Lys His  Arg Lys Phe Tyr Thr  Asn Ser Arg Thr            
1295                 1300                 1305                            

aca  ata gag agt cct tct  agg gaa tta gca gcc  cat tta aga agg        4023
Thr  Ile Glu Ser Pro Ser  Arg Glu Leu Ala Ala  His Leu Arg Arg            
1310                 1315                 1320                            

aag  agg att gga gca act  cag aca agt act gcc  tct tta aaa aga        4068
Lys  Arg Ile Gly Ala Thr  Gln Thr Ser Thr Ala  Ser Leu Lys Arg            
1325                 1330                 1335                            

caa  cct aag aaa cct tcc  caa ccc aag ttc atg  caa ctg ctt ttt        4113
Gln  Pro Lys Lys Pro Ser  Gln Pro Lys Phe Met  Gln Leu Leu Phe            
1340                 1345                 1350                            

cag  agc cta aag cgg gca  ttc caa aca gca cac  aga gtt ata gct        4158
Gln  Ser Leu Lys Arg Ala  Phe Gln Thr Ala His  Arg Val Ile Ala            
1355                 1360                 1365                            

tct  gtt ggg cgg aag cct  gtg gac ggg aca agg  cca gac aat ttg        4203
Ser  Val Gly Arg Lys Pro  Val Asp Gly Thr Arg  Pro Asp Asn Leu            
1370                 1375                 1380                            

tgg  gca agc aaa aac tat  tat cca aaa caa aat  gcc agg gac tat        4248
Trp  Ala Ser Lys Asn Tyr  Tyr Pro Lys Gln Asn  Ala Arg Asp Tyr            
1385                 1390                 1395                            

tgc  tta cca agc agt atc  aaa aga gac aag agg  tca gct gac aag        4293
Cys  Leu Pro Ser Ser Ile  Lys Arg Asp Lys Arg  Ser Ala Asp Lys            
1400                 1405                 1410                            

cta  acg cca gca ggc tca  acc att aag cag gag  gac ata ttg tgg        4338
Leu  Thr Pro Ala Gly Ser  Thr Ile Lys Gln Glu  Asp Ile Leu Trp            
1415                 1420                 1425                            

gga  gga acg gtc cag tgc  aga tca gct caa cag  cca aga aga gct        4383
Gly  Gly Thr Val Gln Cys  Arg Ser Ala Gln Gln  Pro Arg Arg Ala            
1430                 1435                 1440                            

tac  tct ttc caa ccc aga  cct ctt cga ctg ccc  aag ccc aca gat        4428
Tyr  Ser Phe Gln Pro Arg  Pro Leu Arg Leu Pro  Lys Pro Thr Asp            
1445                 1450                 1455                            

tcc  caa agt ggt att gct  ttc caa act gcc tca  gtg ggg cag cct        4473
Ser  Gln Ser Gly Ile Ala  Phe Gln Thr Ala Ser  Val Gly Gln Pro            
1460                 1465                 1470                            

ctg  aga act gtt caa aag  gac agt agt agc aga  tca aag aaa aac        4518
Leu  Arg Thr Val Gln Lys  Asp Ser Ser Ser Arg  Ser Lys Lys Asn            
1475                 1480                 1485                            

ttc  tat aga aat gaa acc  tcc agc cag gag tct  aag aac ttg tcc        4563
Phe  Tyr Arg Asn Glu Thr  Ser Ser Gln Glu Ser  Lys Asn Leu Ser            
1490                 1495                 1500                            

aca  cca gga acc aga gtt  cag gcc cga gga aga  atc cta cct ggt        4608
Thr  Pro Gly Thr Arg Val  Gln Ala Arg Gly Arg  Ile Leu Pro Gly            
1505                 1510                 1515                            

tcc  cct gtg aag aga acc  tgg cac cga cat ctt  aaa gac aaa ctc        4653
Ser  Pro Val Lys Arg Thr  Trp His Arg His Leu  Lys Asp Lys Leu            
1520                 1525                 1530                            

aca  cac aag gag cat aac  cac ccc agc ttc tat  agg gag aga acc        4698
Thr  His Lys Glu His Asn  His Pro Ser Phe Tyr  Arg Glu Arg Thr            
1535                 1540                 1545                            

cca  cgc ggt cct tct gag  aga acc cgt cat aac  ccc tct tgg aga        4743
Pro  Arg Gly Pro Ser Glu  Arg Thr Arg His Asn  Pro Ser Trp Arg            
1550                 1555                 1560                            

aac  cat cgc agt ccc tct  gag aga agc caa cgc  agt tcc ttg gag        4788
Asn  His Arg Ser Pro Ser  Glu Arg Ser Gln Arg  Ser Ser Leu Glu            
1565                 1570                 1575                            

aga  aga cat cac agt ccc  tct cag agg agc cac  tgc agt ccc tct        4833
Arg  Arg His His Ser Pro  Ser Gln Arg Ser His  Cys Ser Pro Ser            
1580                 1585                 1590                            

agg  aaa aac cat tcc agt  cct tct gag aga agc  tgg cgc agt ccg        4878
Arg  Lys Asn His Ser Ser  Pro Ser Glu Arg Ser  Trp Arg Ser Pro            
1595                 1600                 1605                            

tct  cag aga aat cac tgc  agt ccc ccc gag agg  agc tgt cac agt        4923
Ser  Gln Arg Asn His Cys  Ser Pro Pro Glu Arg  Ser Cys His Ser            
1610                 1615                 1620                            

ctc  tct gaa agg ggc ctt  cac agt ccc tct cag  agg agc cat cgc        4968
Leu  Ser Glu Arg Gly Leu  His Ser Pro Ser Gln  Arg Ser His Arg            
1625                 1630                 1635                            

ggt  ccc tct cag aga aga  cat cac agt ccc tca  gag aga agc cat        5013
Gly  Pro Ser Gln Arg Arg  His His Ser Pro Ser  Glu Arg Ser His            
1640                 1645                 1650                            

cgc  agt ccc tca gag aga  agc cat cgc agt tcc  tct gag aga aga        5058
Arg  Ser Pro Ser Glu Arg  Ser His Arg Ser Ser  Ser Glu Arg Arg            
1655                 1660                 1665                            

cat  cgc agt ccc tcc cag  agg agc cat cgc ggt  ccc tca gag aga        5103
His  Arg Ser Pro Ser Gln  Arg Ser His Arg Gly  Pro Ser Glu Arg            
1670                 1675                 1680                            

agc  cat tgc agt ccc tct  gag aga aga cat cgc  agt ccc tct cag        5148
Ser  His Cys Ser Pro Ser  Glu Arg Arg His Arg  Ser Pro Ser Gln            
1685                 1690                 1695                            

agg  agc cat cgt ggt ccc  tct gag aga aga cat  cac agt ccc tct        5193
Arg  Ser His Arg Gly Pro  Ser Glu Arg Arg His  His Ser Pro Ser            
1700                 1705                 1710                            

aag  aga agc cat cgc agt  ccc gct cgg agg agc  cat cgc agt ccc        5238
Lys  Arg Ser His Arg Ser  Pro Ala Arg Arg Ser  His Arg Ser Pro            
1715                 1720                 1725                            

tca  gag aga agc cat cac  agt ccc tct gag aga  agc cat cac agt        5283
Ser  Glu Arg Ser His His  Ser Pro Ser Glu Arg  Ser His His Ser            
1730                 1735                 1740                            

ccc  tct gag aga aga cat  cac agt ccc tct gag  aga agc cat tgc        5328
Pro  Ser Glu Arg Arg His  His Ser Pro Ser Glu  Arg Ser His Cys            
1745                 1750                 1755                            

agt  ccc tct gag aga agc  cat tgc agt ccc tct  gag aga aga cat        5373
Ser  Pro Ser Glu Arg Ser  His Cys Ser Pro Ser  Glu Arg Arg His            
1760                 1765                 1770                            

cgc  agt ccc tct gag aga  aga cat cac agt ccc  tca gag aaa agc        5418
Arg  Ser Pro Ser Glu Arg  Arg His His Ser Pro  Ser Glu Lys Ser            
1775                 1780                 1785                            

cat  cac agt ccc tct gag  aga agc cat cac agt  ccc tct gag aga        5463
His  His Ser Pro Ser Glu  Arg Ser His His Ser  Pro Ser Glu Arg            
1790                 1795                 1800                            

aga  cgt cac agt ccc ttg  gag agg agc cgt cac  agt ctc ttg gag        5508
Arg  Arg His Ser Pro Leu  Glu Arg Ser Arg His  Ser Leu Leu Glu            
1805                 1810                 1815                            

agg  agc cat cgc agt ccc  tct gag agg aga tct  cac agg tcc ttt        5553
Arg  Ser His Arg Ser Pro  Ser Glu Arg Arg Ser  His Arg Ser Phe            
1820                 1825                 1830                            

gag  agg agc cat cgt agg  att tct gag aga agt  cac agt ccc tca        5598
Glu  Arg Ser His Arg Arg  Ile Ser Glu Arg Ser  His Ser Pro Ser            
1835                 1840                 1845                            

gag  aag agc cac ctc agt  ccc ttg gaa aga agc  cgt tgc agt ccc        5643
Glu  Lys Ser His Leu Ser  Pro Leu Glu Arg Ser  Arg Cys Ser Pro            
1850                 1855                 1860                            

tct  gag agg aga gga cac  agt tcc tct ggg aaa  acc tgt cac agt        5688
Ser  Glu Arg Arg Gly His  Ser Ser Ser Gly Lys  Thr Cys His Ser            
1865                 1870                 1875                            

ccc  tct gag aga agc cat  cgc agt ccc tcc ggg  atg agg caa ggg        5733
Pro  Ser Glu Arg Ser His  Arg Ser Pro Ser Gly  Met Arg Gln Gly            
1880                 1885                 1890                            

agg  acc tct gag agg agc  cat cgc agt tcc tgt  gag aga acc cgt        5778
Arg  Thr Ser Glu Arg Ser  His Arg Ser Ser Cys  Glu Arg Thr Arg            
1895                 1900                 1905                            

cac  agt ccc tct gag atg  agg cca ggg agg ccc  tct ggg agg aac        5823
His  Ser Pro Ser Glu Met  Arg Pro Gly Arg Pro  Ser Gly Arg Asn            
1910                 1915                 1920                            

cat  tgc agt ccc tct gag  agg agc cga cgc agt  ccc ctt aag gag        5868
His  Cys Ser Pro Ser Glu  Arg Ser Arg Arg Ser  Pro Leu Lys Glu            
1925                 1930                 1935                            

gga  ctc aag tac agt ttc  cct gga gag agg ccc  agc cat agt ttg        5913
Gly  Leu Lys Tyr Ser Phe  Pro Gly Glu Arg Pro  Ser His Ser Leu            
1940                 1945                 1950                            

tct  aga gat ttc aag aat  caa aca act ctc ctc  ggg acc aca cat        5958
Ser  Arg Asp Phe Lys Asn  Gln Thr Thr Leu Leu  Gly Thr Thr His            
1955                 1960                 1965                            

aaa  aat ccc aaa gca ggg  caa gtg tgg agg cct  gaa gct act cga        6003
Lys  Asn Pro Lys Ala Gly  Gln Val Trp Arg Pro  Glu Ala Thr Arg            
1970                 1975                 1980                            

tga ggcgaggtcc gcccctatta ttcattgtcc taagtcttca tcgtgctgcc            6056

ctttccaggc ttctttcctg ctcagccact gcctccaatt cctgcgcccc cagcgtggaa     6116

aggcttccat ttctctctac cgggggggag gcgggtgaga atgggtctgt aatttctcta     6176

agatgaataa aggggcagta aatgaaaaaa aaaaaaaaaa aa                        6218


<210>  770
<211>  1984
<212>  PRT
<213>  Homo sapiens

<400>  770

Met Glu Leu Thr Pro Gly Ala Gln Gln Gln Gly Ile Asn Tyr Gln Glu 
1               5                   10                  15      


Leu Thr Ser Gly Trp Gln Asp Val Lys Ser Met Met Leu Val Pro Glu 
            20                  25                  30          


Pro Thr Arg Lys Phe Pro Ser Gly Pro Leu Leu Thr Ser Val Arg Phe 
        35                  40                  45              


Ser Asn Leu Ser Pro Glu Ser Gln Gln Gln Asp Val Lys Ser Leu Glu 
    50                  55                  60                  


Phe Thr Val Glu Pro Lys Leu Gln Ser Val Lys His Val Lys Leu Ser 
65                  70                  75                  80  


Ser Val Ser Leu Gln Gln Thr Ile Lys Ser Val Glu Leu Ala Pro Gly 
                85                  90                  95      


Ser Leu Pro Gln Arg Val Lys Tyr Gly Glu Gln Thr Pro Arg Thr Asn 
            100                 105                 110         


Tyr Gln Ile Met Glu Ser Ser Glu Leu Ile Pro Arg Pro Gly His Gln 
        115                 120                 125             


Phe Ala Lys Tyr Ala Glu Met Ile Pro Gln Pro Lys Tyr Gln Ile Pro 
    130                 135                 140                 


Lys Ser Ala Asn Leu Ile Ser Ile Pro Ile Tyr His Ala Thr Glu Ser 
145                 150                 155                 160 


Ser Glu Met Ala Gln Gly Leu Ala Tyr Lys Gly Ile Asp Thr Val Glu 
                165                 170                 175     


Lys Ser Val Gly Leu Thr Pro Lys Leu Thr Gly Arg Ala Lys Glu Ser 
            180                 185                 190         


Leu Gly Met Leu Leu Gln Pro Asp Leu Gln Val Pro Lys Phe Val Asp 
        195                 200                 205             


Leu Thr Pro Met Val Arg Asp Gln Gly Ser Lys Phe Leu Gly Leu Thr 
    210                 215                 220                 


Pro Glu Lys Ser Tyr Gln Ile Leu Glu Thr Met Glu Leu Leu Ser Gln 
225                 230                 235                 240 


Ser Arg Pro Arg Val Lys Asp Val Gly Glu Leu Tyr Met Lys Pro Leu 
                245                 250                 255     


Gln Gln Thr Val Glu Tyr Glu Gly Ile Thr Pro Glu Leu Lys His Tyr 
            260                 265                 270         


Phe Thr Glu Ala Met Gly Leu Thr Ala Glu Ala Arg Ile Gln Ala Asn 
        275                 280                 285             


Glu Phe Phe Gly Met Thr Pro Lys Pro Thr Ser Gln Ala Thr Gly Phe 
    290                 295                 300                 


Ala Glu Arg Ser Pro Arg Leu Cys Pro Gln Asn Leu Glu Cys Val Glu 
305                 310                 315                 320 


Val Ile Ser Glu Lys Arg Leu Gln Gly Glu Glu Ser Val Val Leu Ile 
                325                 330                 335     


Pro Lys Ser Leu His His Val Pro Asp Ser Ala Ser Gly Met Thr Pro 
            340                 345                 350         


Gly Leu Gly His Arg Val Pro Glu Ser Val Glu Leu Thr Ser Lys Ser 
        355                 360                 365             


Gly Val Gln Val Glu Lys Thr Leu Gln Leu Thr Pro Lys Pro Gln His 
    370                 375                 380                 


His Val Gly Ser Pro Gly Ile Ile Ser Gly Leu Gly His Gln Val Pro 
385                 390                 395                 400 


Glu Ser Val Asn Leu Thr Cys Lys Gln Trp Leu Gln Met Glu Glu Ser 
                405                 410                 415     


Leu Glu Val Pro Leu Lys Gln Thr Ser Gln Val Ile Gly His Glu Glu 
            420                 425                 430         


Ser Val Glu Leu Thr Ser Glu Ala Arg Gln His Arg Glu Val Ser Met 
        435                 440                 445             


Gly Leu Thr Lys Ser Lys Asn Gln Ser Met Lys Ser Pro Gly Thr Thr 
    450                 455                 460                 


Pro Gly Pro Leu Gly Arg Ile Val Glu Phe Met Arg Ile Ser Pro Glu 
465                 470                 475                 480 


Pro Leu Asp Gln Val Thr Glu Ser Ala Arg Thr Gln Leu Gln Val Ala 
                485                 490                 495     


Gln Ser Glu Glu Val Ile Leu Ile Asp Val Pro Lys Val Val Gln Ser 
            500                 505                 510         


Val Lys Val Thr Pro Gly Pro Pro Phe Gln Ile Val Lys Ser Val Thr 
        515                 520                 525             


Ile Pro Arg Pro Thr Pro Gln Met Val Glu Tyr Ile Glu Leu Thr Pro 
    530                 535                 540                 


Lys Leu Gln Tyr Val Arg Pro Ser Glu His His Thr Gly Pro Cys Leu 
545                 550                 555                 560 


Gln Asp Val Lys Ser Thr Lys Leu Ile Thr Lys Pro Lys His Gln Ile 
                565                 570                 575     


Leu Glu Thr Val Glu Leu Thr Gly Phe Gln Ile Val Lys Thr Met Leu 
            580                 585                 590         


Ile Pro Gly Pro Ser Leu Gln Ile Val Lys Ser Glu Glu Leu Ala Pro 
        595                 600                 605             


Gly Pro Ile Pro Gln Val Val Glu Pro Ile Gly Val Ala Leu Glu Ser 
    610                 615                 620                 


Gly Ile Glu Ala Ile Asn Cys Val Asp Leu Leu Pro Arg Pro His Leu 
625                 630                 635                 640 


Gln Glu Leu Ile Val Pro Ala Glu Leu Thr Pro Ser Pro Cys Thr Gln 
                645                 650                 655     


Val Lys Ser Ala Glu Leu Thr Ser Pro Gln Thr Ser Pro Phe Glu Glu 
            660                 665                 670         


His Thr Ile Leu Thr His Lys Gln Gly Leu Gln Ala Val Lys Ser Thr 
        675                 680                 685             


Val Ile Lys Thr Glu Pro Pro Lys Val Met Glu Thr Glu Asp Leu Asn 
    690                 695                 700                 


Leu Gly His Val Cys Gln Asn Arg Asp Cys Gln Lys Leu Thr Ser Glu 
705                 710                 715                 720 


Glu Leu Gln Val Gly Thr Asp Phe Ser Arg Phe Leu Gln Ser Ser Ser 
                725                 730                 735     


Thr Thr Leu Ile Ser Ser Ser Val Arg Thr Ala Ser Glu Leu Gly Gly 
            740                 745                 750         


Leu Trp Asp Ser Gly Ile Gln Glu Val Ser Arg Ala Leu Asp Ile Lys 
        755                 760                 765             


Asn Pro Gly Thr Asp Ile Leu Gln Pro Glu Glu Thr Tyr Ile Asp Pro 
    770                 775                 780                 


Thr Met Ile Gln Ser Leu Thr Phe Pro Leu Ala Leu His Asn Gln Ser 
785                 790                 795                 800 


Ser Asp Lys Thr Ala Asn Ile Val Glu Asn Pro Cys Pro Glu Ile Leu 
                805                 810                 815     


Gly Val Asp Val Ile Ser Lys Glu Thr Thr Lys Arg Lys Gln Met Glu 
            820                 825                 830         


Glu Leu Glu Asn Ser Leu Gln Arg His Leu Pro Gln Ser Trp Arg Ser 
        835                 840                 845             


Arg Ser Arg Thr Phe Gln Ala Glu Ser Gly Val Gln Lys Gly Leu Ile 
    850                 855                 860                 


Lys Ser Phe Pro Gly Arg Gln His Asn Val Trp Glu Ser His Ala Trp 
865                 870                 875                 880 


Arg Gln Arg Leu Pro Arg Lys Tyr Leu Ser Thr Met Leu Met Leu Gly 
                885                 890                 895     


Asn Ile Leu Gly Thr Thr Met Glu Arg Lys Leu Cys Ser Gln Thr Ser 
            900                 905                 910         


Leu Ala Glu Arg Ala Thr Ala Asp Thr Cys Gln Ser Ile Gln Asn Leu 
        915                 920                 925             


Phe Gly Ile Pro Ala Glu Leu Met Glu Pro Ser Gln Ser Leu Pro Glu 
    930                 935                 940                 


Lys Gly Pro Val Thr Ile Ser Gln Pro Ser Val Val Lys Asn Tyr Ile 
945                 950                 955                 960 


Gln Arg His Thr Phe Tyr His Gly His Lys Lys Arg Met Ala Leu Arg 
                965                 970                 975     


Ile Trp Thr Arg Gly Ser Thr Ser Ser Ile Ile Gln Gln Tyr Ser Gly 
            980                 985                 990         


Thr Arg Val Arg Ile Lys Lys Thr  Asn Ser Thr Phe Asn  Gly Ile Ser 
        995                 1000                 1005             


Gln Glu  Val Ile Gln His Met  Pro Val Ser Cys Ala  Gly Gly Gln 
    1010                 1015                 1020             


Leu Pro  Val Leu Val Lys Ser  Glu Ser Ser Leu Ser  Ile Phe Tyr 
    1025                 1030                 1035             


Asp Arg  Glu Asp Leu Val Pro  Met Glu Glu Ser Glu  Asp Ser Gln 
    1040                 1045                 1050             


Ser Asp  Ser Gln Thr Arg Ile  Ser Glu Ser Gln His  Ser Leu Lys 
    1055                 1060                 1065             


Pro Asn  Tyr Leu Ser Gln Ala  Lys Thr Asp Phe Ser  Glu Gln Phe 
    1070                 1075                 1080             


Gln Leu  Leu Glu Asp Leu Gln  Leu Lys Ile Ala Ala  Lys Leu Leu 
    1085                 1090                 1095             


Arg Ser  Gln Ile Pro Pro Asp  Val Pro Pro Pro Leu  Ala Ser Gly 
    1100                 1105                 1110             


Leu Val  Leu Lys Tyr Pro Ile  Cys Leu Gln Cys Gly  Arg Cys Ser 
    1115                 1120                 1125             


Gly Leu  Asn Cys His His Lys  Leu Gln Thr Thr Ser  Gly Pro Tyr 
    1130                 1135                 1140             


Leu Leu  Ile Tyr Pro Gln Leu  His Leu Val Arg Thr  Pro Glu Gly 
    1145                 1150                 1155             


His Gly  Glu Val Arg Leu His  Leu Gly Phe Arg Leu  Arg Ile Gly 
    1160                 1165                 1170             


Lys Arg  Ser Gln Ile Ser Lys  Tyr Arg Glu Arg Asp  Arg Pro Val 
    1175                 1180                 1185             


Ile Arg  Arg Ser Pro Ile Ser  Pro Ser Gln Arg Lys  Ala Lys Ile 
    1190                 1195                 1200             


Tyr Thr  Gln Ala Ser Lys Ser  Pro Thr Ser Thr Ile  Asp Leu Gln 
    1205                 1210                 1215             


Ser Gly  Pro Ser Gln Ser Pro  Ala Pro Val Gln Val  Tyr Ile Arg 
    1220                 1225                 1230             


Arg Gly  Gln Arg Ser Arg Pro  Asp Leu Val Glu Lys  Thr Lys Thr 
    1235                 1240                 1245             


Arg Ala  Pro Gly His Tyr Glu  Phe Thr Gln Val His  Asn Leu Pro 
    1250                 1255                 1260             


Glu Ser  Asp Ser Glu Ser Thr  Gln Asn Glu Lys Arg  Ala Lys Val 
    1265                 1270                 1275             


Arg Thr  Lys Lys Thr Ser Asp  Ser Lys Tyr Pro Met  Lys Arg Ile 
    1280                 1285                 1290             


Thr Lys  Arg Leu Arg Lys His  Arg Lys Phe Tyr Thr  Asn Ser Arg 
    1295                 1300                 1305             


Thr Thr  Ile Glu Ser Pro Ser  Arg Glu Leu Ala Ala  His Leu Arg 
    1310                 1315                 1320             


Arg Lys  Arg Ile Gly Ala Thr  Gln Thr Ser Thr Ala  Ser Leu Lys 
    1325                 1330                 1335             


Arg Gln  Pro Lys Lys Pro Ser  Gln Pro Lys Phe Met  Gln Leu Leu 
    1340                 1345                 1350             


Phe Gln  Ser Leu Lys Arg Ala  Phe Gln Thr Ala His  Arg Val Ile 
    1355                 1360                 1365             


Ala Ser  Val Gly Arg Lys Pro  Val Asp Gly Thr Arg  Pro Asp Asn 
    1370                 1375                 1380             


Leu Trp  Ala Ser Lys Asn Tyr  Tyr Pro Lys Gln Asn  Ala Arg Asp 
    1385                 1390                 1395             


Tyr Cys  Leu Pro Ser Ser Ile  Lys Arg Asp Lys Arg  Ser Ala Asp 
    1400                 1405                 1410             


Lys Leu  Thr Pro Ala Gly Ser  Thr Ile Lys Gln Glu  Asp Ile Leu 
    1415                 1420                 1425             


Trp Gly  Gly Thr Val Gln Cys  Arg Ser Ala Gln Gln  Pro Arg Arg 
    1430                 1435                 1440             


Ala Tyr  Ser Phe Gln Pro Arg  Pro Leu Arg Leu Pro  Lys Pro Thr 
    1445                 1450                 1455             


Asp Ser  Gln Ser Gly Ile Ala  Phe Gln Thr Ala Ser  Val Gly Gln 
    1460                 1465                 1470             


Pro Leu  Arg Thr Val Gln Lys  Asp Ser Ser Ser Arg  Ser Lys Lys 
    1475                 1480                 1485             


Asn Phe  Tyr Arg Asn Glu Thr  Ser Ser Gln Glu Ser  Lys Asn Leu 
    1490                 1495                 1500             


Ser Thr  Pro Gly Thr Arg Val  Gln Ala Arg Gly Arg  Ile Leu Pro 
    1505                 1510                 1515             


Gly Ser  Pro Val Lys Arg Thr  Trp His Arg His Leu  Lys Asp Lys 
    1520                 1525                 1530             


Leu Thr  His Lys Glu His Asn  His Pro Ser Phe Tyr  Arg Glu Arg 
    1535                 1540                 1545             


Thr Pro  Arg Gly Pro Ser Glu  Arg Thr Arg His Asn  Pro Ser Trp 
    1550                 1555                 1560             


Arg Asn  His Arg Ser Pro Ser  Glu Arg Ser Gln Arg  Ser Ser Leu 
    1565                 1570                 1575             


Glu Arg  Arg His His Ser Pro  Ser Gln Arg Ser His  Cys Ser Pro 
    1580                 1585                 1590             


Ser Arg  Lys Asn His Ser Ser  Pro Ser Glu Arg Ser  Trp Arg Ser 
    1595                 1600                 1605             


Pro Ser  Gln Arg Asn His Cys  Ser Pro Pro Glu Arg  Ser Cys His 
    1610                 1615                 1620             


Ser Leu  Ser Glu Arg Gly Leu  His Ser Pro Ser Gln  Arg Ser His 
    1625                 1630                 1635             


Arg Gly  Pro Ser Gln Arg Arg  His His Ser Pro Ser  Glu Arg Ser 
    1640                 1645                 1650             


His Arg  Ser Pro Ser Glu Arg  Ser His Arg Ser Ser  Ser Glu Arg 
    1655                 1660                 1665             


Arg His  Arg Ser Pro Ser Gln  Arg Ser His Arg Gly  Pro Ser Glu 
    1670                 1675                 1680             


Arg Ser  His Cys Ser Pro Ser  Glu Arg Arg His Arg  Ser Pro Ser 
    1685                 1690                 1695             


Gln Arg  Ser His Arg Gly Pro  Ser Glu Arg Arg His  His Ser Pro 
    1700                 1705                 1710             


Ser Lys  Arg Ser His Arg Ser  Pro Ala Arg Arg Ser  His Arg Ser 
    1715                 1720                 1725             


Pro Ser  Glu Arg Ser His His  Ser Pro Ser Glu Arg  Ser His His 
    1730                 1735                 1740             


Ser Pro  Ser Glu Arg Arg His  His Ser Pro Ser Glu  Arg Ser His 
    1745                 1750                 1755             


Cys Ser  Pro Ser Glu Arg Ser  His Cys Ser Pro Ser  Glu Arg Arg 
    1760                 1765                 1770             


His Arg  Ser Pro Ser Glu Arg  Arg His His Ser Pro  Ser Glu Lys 
    1775                 1780                 1785             


Ser His  His Ser Pro Ser Glu  Arg Ser His His Ser  Pro Ser Glu 
    1790                 1795                 1800             


Arg Arg  Arg His Ser Pro Leu  Glu Arg Ser Arg His  Ser Leu Leu 
    1805                 1810                 1815             


Glu Arg  Ser His Arg Ser Pro  Ser Glu Arg Arg Ser  His Arg Ser 
    1820                 1825                 1830             


Phe Glu  Arg Ser His Arg Arg  Ile Ser Glu Arg Ser  His Ser Pro 
    1835                 1840                 1845             


Ser Glu  Lys Ser His Leu Ser  Pro Leu Glu Arg Ser  Arg Cys Ser 
    1850                 1855                 1860             


Pro Ser  Glu Arg Arg Gly His  Ser Ser Ser Gly Lys  Thr Cys His 
    1865                 1870                 1875             


Ser Pro  Ser Glu Arg Ser His  Arg Ser Pro Ser Gly  Met Arg Gln 
    1880                 1885                 1890             


Gly Arg  Thr Ser Glu Arg Ser  His Arg Ser Ser Cys  Glu Arg Thr 
    1895                 1900                 1905             


Arg His  Ser Pro Ser Glu Met  Arg Pro Gly Arg Pro  Ser Gly Arg 
    1910                 1915                 1920             


Asn His  Cys Ser Pro Ser Glu  Arg Ser Arg Arg Ser  Pro Leu Lys 
    1925                 1930                 1935             


Glu Gly  Leu Lys Tyr Ser Phe  Pro Gly Glu Arg Pro  Ser His Ser 
    1940                 1945                 1950             


Leu Ser  Arg Asp Phe Lys Asn  Gln Thr Thr Leu Leu  Gly Thr Thr 
    1955                 1960                 1965             


His Lys  Asn Pro Lys Ala Gly  Gln Val Trp Arg Pro  Glu Ala Thr 
    1970                 1975                 1980             


Arg 
    


<210>  771
<211>  846
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(531)

<400>  771
atg cgc cct ccg ccc gcg gtt cag ccc cgg cac agc cgg ctc gac tcc         48
Met Arg Pro Pro Pro Ala Val Gln Pro Arg His Ser Arg Leu Asp Ser           
1               5                   10                  15                

ggt cct cgc ggc cgg ccg gct aag ttc ccg cga ggg acc gcc tac cca         96
Gly Pro Arg Gly Arg Pro Ala Lys Phe Pro Arg Gly Thr Ala Tyr Pro           
            20                  25                  30                    

ctc tcc ccg ccc cgg gaa gaa ctg cgc cgc tcc cgg gat ttt tcg gac        144
Leu Ser Pro Pro Arg Glu Glu Leu Arg Arg Ser Arg Asp Phe Ser Asp           
        35                  40                  45                        

tcg ccc agc agc ttg cga gcg ggc ggg cag ccg ccg ggg cag agc gca        192
Ser Pro Ser Ser Leu Arg Ala Gly Gly Gln Pro Pro Gly Gln Ser Ala           
    50                  55                  60                            

ggc gga aaa cga aag cgc agc acg agt cgc ggc cgc ttt gtc tcg ggc        240
Gly Gly Lys Arg Lys Arg Ser Thr Ser Arg Gly Arg Phe Val Ser Gly           
65                  70                  75                  80            

gcc gcg ggc ctg acg ggg aca gcg cgg gct ggg agc gcc ggc aag ggc        288
Ala Ala Gly Leu Thr Gly Thr Ala Arg Ala Gly Ser Ala Gly Lys Gly           
                85                  90                  95                

ggc cct cgc gca cct ggc tgc cag ccc gca ggg ggc tcg cac gca gac        336
Gly Pro Arg Ala Pro Gly Cys Gln Pro Ala Gly Gly Ser His Ala Asp           
            100                 105                 110                   

ctg ccc ttg cca cct cag cgc tcg ggt gcg ggc tgg ggg cgg tgg agc        384
Leu Pro Leu Pro Pro Gln Arg Ser Gly Ala Gly Trp Gly Arg Trp Ser           
        115                 120                 125                       

cac gaa agg tgg tgc cga gag cgg agc gca gga cag cgc agg agc ccc        432
His Glu Arg Trp Cys Arg Glu Arg Ser Ala Gly Gln Arg Arg Ser Pro           
    130                 135                 140                           

ggc gca tcg cgg cgc gca cag acc cag gat tac ttc atg cac ata aaa        480
Gly Ala Ser Arg Arg Ala Gln Thr Gln Asp Tyr Phe Met His Ile Lys           
145                 150                 155                 160           

gaa aac gca act aca gtg gac cct gaa caa cct atg gcc tgc agc cac        528
Glu Asn Ala Thr Thr Val Asp Pro Glu Gln Pro Met Ala Cys Ser His           
                165                 170                 175               

tga agaatgcttg cataaggagc tcttctctgc acataccccg acacagtgat             581

ggtatcttgc agctgctgct tctgtccaag gcactgcagc ctactcgtca aaagcccgaa      641

gcccagctct gccagcagtg cactgtgtgc tcttaggaaa cagagaagca aagaagttag      701

caagcttgtt ttggcagaag aaaaaacaca aaatacccaa ccacagatcc tcaaaaatat      761

tgctaagcac taattttgct aacatgttag acagccttcg gatctaggca atcttgttcc      821

tcagctggaa agagttcctg ccagc                                            846


<210>  772
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  772

Met Arg Pro Pro Pro Ala Val Gln Pro Arg His Ser Arg Leu Asp Ser 
1               5                   10                  15      


Gly Pro Arg Gly Arg Pro Ala Lys Phe Pro Arg Gly Thr Ala Tyr Pro 
            20                  25                  30          


Leu Ser Pro Pro Arg Glu Glu Leu Arg Arg Ser Arg Asp Phe Ser Asp 
        35                  40                  45              


Ser Pro Ser Ser Leu Arg Ala Gly Gly Gln Pro Pro Gly Gln Ser Ala 
    50                  55                  60                  


Gly Gly Lys Arg Lys Arg Ser Thr Ser Arg Gly Arg Phe Val Ser Gly 
65                  70                  75                  80  


Ala Ala Gly Leu Thr Gly Thr Ala Arg Ala Gly Ser Ala Gly Lys Gly 
                85                  90                  95      


Gly Pro Arg Ala Pro Gly Cys Gln Pro Ala Gly Gly Ser His Ala Asp 
            100                 105                 110         


Leu Pro Leu Pro Pro Gln Arg Ser Gly Ala Gly Trp Gly Arg Trp Ser 
        115                 120                 125             


His Glu Arg Trp Cys Arg Glu Arg Ser Ala Gly Gln Arg Arg Ser Pro 
    130                 135                 140                 


Gly Ala Ser Arg Arg Ala Gln Thr Gln Asp Tyr Phe Met His Ile Lys 
145                 150                 155                 160 


Glu Asn Ala Thr Thr Val Asp Pro Glu Gln Pro Met Ala Cys Ser His 
                165                 170                 175     


<210>  773
<211>  4298
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (157)..(3858)

<400>  773
catcgcgagt gtccttgagc cgcgggtgac ggtggctctc gctgctcgcg ccccctcctc       60

ccgcgggggg agcctgatgc cacgttccct atgaattatt tatcgccggc ctaaaaatac      120

cccgaacttc acagcccgag tgaccctccg gtggac atg ggt ggg gcc ctg ggg        174
                                        Met Gly Gly Ala Leu Gly           
                                        1               5                 

ccg gcc ctg ttg ctc acc tcg ctc ttc ggt gcc tgg gca ggg ctg ggt        222
Pro Ala Leu Leu Leu Thr Ser Leu Phe Gly Ala Trp Ala Gly Leu Gly           
            10                  15                  20                    

ccg ggg cag ggc gag cag ggc atg acg gtg gcc gtg gtg ttt agc agc        270
Pro Gly Gln Gly Glu Gln Gly Met Thr Val Ala Val Val Phe Ser Ser           
        25                  30                  35                        

tca ggg ccg ccc cag gcc cag ttc cgt gcc cgc ctc acc ccc cag agc        318
Ser Gly Pro Pro Gln Ala Gln Phe Arg Ala Arg Leu Thr Pro Gln Ser           
    40                  45                  50                            

ttc ctg gac cta ccc ctg gag atc cag ccg ctc aca gtt ggg gtc aac        366
Phe Leu Asp Leu Pro Leu Glu Ile Gln Pro Leu Thr Val Gly Val Asn           
55                  60                  65                  70            

acc acc aac ccc agc agc ctc ctc acc cag atc tgc ggc ctc ctg ggt        414
Thr Thr Asn Pro Ser Ser Leu Leu Thr Gln Ile Cys Gly Leu Leu Gly           
                75                  80                  85                

gct gcc cac gtc cac ggc att gtc ttt gag gac aac gtg gac acc gag        462
Ala Ala His Val His Gly Ile Val Phe Glu Asp Asn Val Asp Thr Glu           
            90                  95                  100                   

gcg gtg gcc cag atc ctt gac ttc atc tcc tcc cag acc cat gtg ccc        510
Ala Val Ala Gln Ile Leu Asp Phe Ile Ser Ser Gln Thr His Val Pro           
        105                 110                 115                       

atc ctc agc atc agc gga ggc tct gct gtg gtc ctc acc ccc aag gag        558
Ile Leu Ser Ile Ser Gly Gly Ser Ala Val Val Leu Thr Pro Lys Glu           
    120                 125                 130                           

ccg ggc tcc gcc ttc ctg cag ctg ggc gtg tcc ctg gag cag cag ctg        606
Pro Gly Ser Ala Phe Leu Gln Leu Gly Val Ser Leu Glu Gln Gln Leu           
135                 140                 145                 150           

cag gtg ctg ttc aag gtg ctg gaa gag tac gac tgg agc gcc ttc gcc        654
Gln Val Leu Phe Lys Val Leu Glu Glu Tyr Asp Trp Ser Ala Phe Ala           
                155                 160                 165               

gtc atc acc agc ctg cac ccg ggc cac gcg ctc ttc ctg gag ggc gtg        702
Val Ile Thr Ser Leu His Pro Gly His Ala Leu Phe Leu Glu Gly Val           
            170                 175                 180                   

cgc gcc gtc gcc gac gcc agc cac gtg agt tgg cgg ctg ctg gac gtg        750
Arg Ala Val Ala Asp Ala Ser His Val Ser Trp Arg Leu Leu Asp Val           
        185                 190                 195                       

gtc acg ctg gag ctg ggc ccg gga ggg ccg cgc gcg cgc acg cag cgc        798
Val Thr Leu Glu Leu Gly Pro Gly Gly Pro Arg Ala Arg Thr Gln Arg           
    200                 205                 210                           

ctg ctg cgc cag ctc gac gcg ccc gtg ttt gtg gcc tac tgc tcg cgc        846
Leu Leu Arg Gln Leu Asp Ala Pro Val Phe Val Ala Tyr Cys Ser Arg           
215                 220                 225                 230           

gag gag gcc gag gtg ctc ttc gcc gag gcg gcg cag gcc ggt ctg gtg        894
Glu Glu Ala Glu Val Leu Phe Ala Glu Ala Ala Gln Ala Gly Leu Val           
                235                 240                 245               

ggg ccc ggc cac gtg tgg ctg gtg ccc aac ctg gcg ctg ggc agc acc        942
Gly Pro Gly His Val Trp Leu Val Pro Asn Leu Ala Leu Gly Ser Thr           
            250                 255                 260                   

gat gcg ccc ccc gcc acc ttc ccc gtg ggc ctc atc agc gtc gtc acc        990
Asp Ala Pro Pro Ala Thr Phe Pro Val Gly Leu Ile Ser Val Val Thr           
        265                 270                 275                       

gag agc tgg cgc ctc agc ctg cgc cag aag gtg cgc gac ggc gtg gcc       1038
Glu Ser Trp Arg Leu Ser Leu Arg Gln Lys Val Arg Asp Gly Val Ala           
    280                 285                 290                           

att ctg gcc ctg ggc gcc cac agc tac tgg cgc cag cat gga acc ctg       1086
Ile Leu Ala Leu Gly Ala His Ser Tyr Trp Arg Gln His Gly Thr Leu           
295                 300                 305                 310           

cca gcc ccg gcc ggg gac tgc cgt gtt cac cct ggg ccc gtc agc cct       1134
Pro Ala Pro Ala Gly Asp Cys Arg Val His Pro Gly Pro Val Ser Pro           
                315                 320                 325               

gcc cgg gag gcc ttc tac agg cac cta ctg aat gtc acc tgg gag ggc       1182
Ala Arg Glu Ala Phe Tyr Arg His Leu Leu Asn Val Thr Trp Glu Gly           
            330                 335                 340                   

cga gac ttc tcc ttc agc cct ggt ggg tac ctg gtc cag ccc acc atg       1230
Arg Asp Phe Ser Phe Ser Pro Gly Gly Tyr Leu Val Gln Pro Thr Met           
        345                 350                 355                       

gtg gtg atc gcc ctc aac cgg cac cgc ctc tgg gag atg gtg ggg cgc       1278
Val Val Ile Ala Leu Asn Arg His Arg Leu Trp Glu Met Val Gly Arg           
    360                 365                 370                           

tgg gag cat ggc gtc cta tac atg aag tac ccc gtg tgg cct cgc tac       1326
Trp Glu His Gly Val Leu Tyr Met Lys Tyr Pro Val Trp Pro Arg Tyr           
375                 380                 385                 390           

agt gcc tct ctg cag cct gtg gtg gac agt cgg cac ctg acg gtg gcc       1374
Ser Ala Ser Leu Gln Pro Val Val Asp Ser Arg His Leu Thr Val Ala           
                395                 400                 405               

acg ctg gaa gag cgg ccc ttt gtc atc gtg gag agc cct gac cct ggc       1422
Thr Leu Glu Glu Arg Pro Phe Val Ile Val Glu Ser Pro Asp Pro Gly           
            410                 415                 420                   

aca gga ggc tgt gtc ccc aac acc gtg ccc tgc cgc agg cag agc aac       1470
Thr Gly Gly Cys Val Pro Asn Thr Val Pro Cys Arg Arg Gln Ser Asn           
        425                 430                 435                       

cac acc ttc agc agc ggg gac gtg gcc ccc tac acc aag ctc tgc tgt       1518
His Thr Phe Ser Ser Gly Asp Val Ala Pro Tyr Thr Lys Leu Cys Cys           
    440                 445                 450                           

aag gga ttc tgc atc gac atc ctc aag aag ctg gcc aga gtg gtc aaa       1566
Lys Gly Phe Cys Ile Asp Ile Leu Lys Lys Leu Ala Arg Val Val Lys           
455                 460                 465                 470           

ttc tcc tac gac ctg tac ctg gtg acc aac ggc aag cat ggc aag cgg       1614
Phe Ser Tyr Asp Leu Tyr Leu Val Thr Asn Gly Lys His Gly Lys Arg           
                475                 480                 485               

gtg cgc ggc gta tgg aac ggc atg att ggg gag gtg tac tac aag cgg       1662
Val Arg Gly Val Trp Asn Gly Met Ile Gly Glu Val Tyr Tyr Lys Arg           
            490                 495                 500                   

gca gac atg gcc atc ggc tcc ctc acc atc aat gag gaa cgc tcc gag       1710
Ala Asp Met Ala Ile Gly Ser Leu Thr Ile Asn Glu Glu Arg Ser Glu           
        505                 510                 515                       

atc gta gac ttc tct gta ccc ttt gtg gag acg ggc atc agt gtg atg       1758
Ile Val Asp Phe Ser Val Pro Phe Val Glu Thr Gly Ile Ser Val Met           
    520                 525                 530                           

gtg gct cgc agc aat ggc acc gtc tcc ccc tcg gcc ttc ttg gag cca       1806
Val Ala Arg Ser Asn Gly Thr Val Ser Pro Ser Ala Phe Leu Glu Pro           
535                 540                 545                 550           

tat agc cct gca gtg tgg gtg atg atg ttt gtc atg tgc ctc act gtg       1854
Tyr Ser Pro Ala Val Trp Val Met Met Phe Val Met Cys Leu Thr Val           
                555                 560                 565               

gtg gcc atc acc gtc ttc atg ttc gag tac ttc agc cct gtc agc tac       1902
Val Ala Ile Thr Val Phe Met Phe Glu Tyr Phe Ser Pro Val Ser Tyr           
            570                 575                 580                   

aac cag aac ctc acc aga ggc aag aag tcc ggg ggc cca gct ttc act       1950
Asn Gln Asn Leu Thr Arg Gly Lys Lys Ser Gly Gly Pro Ala Phe Thr           
        585                 590                 595                       

atc ggc aag tcc gtg tgg ctg ctg tgg gcg ctg gtc ttc aac aac tca       1998
Ile Gly Lys Ser Val Trp Leu Leu Trp Ala Leu Val Phe Asn Asn Ser           
    600                 605                 610                           

gtg ccc atc gag aac ccg cgg ggc acc acc agc aag atc atg gtt ctg       2046
Val Pro Ile Glu Asn Pro Arg Gly Thr Thr Ser Lys Ile Met Val Leu           
615                 620                 625                 630           

gtc tgg gcc ttc ttt gct gtc atc ttc ctc gcc agc tac acg gcc aac       2094
Val Trp Ala Phe Phe Ala Val Ile Phe Leu Ala Ser Tyr Thr Ala Asn           
                635                 640                 645               

ctg gcc gcc ttc atg atc caa gag caa tac atc gac act gtg tcg ggc       2142
Leu Ala Ala Phe Met Ile Gln Glu Gln Tyr Ile Asp Thr Val Ser Gly           
            650                 655                 660                   

ctc agt gac aag aag ttt cag cgg cct caa gat cag tac cca cct ttc       2190
Leu Ser Asp Lys Lys Phe Gln Arg Pro Gln Asp Gln Tyr Pro Pro Phe           
        665                 670                 675                       

cgc ttc ggc acg gtg ccc aac ggc agc acg gag cgg aac atc cgc agt       2238
Arg Phe Gly Thr Val Pro Asn Gly Ser Thr Glu Arg Asn Ile Arg Ser           
    680                 685                 690                           

aac tac cgt gac atg cac acc cac atg gtc aag ttc aac cag cgc tcg       2286
Asn Tyr Arg Asp Met His Thr His Met Val Lys Phe Asn Gln Arg Ser           
695                 700                 705                 710           

gtg gag gac gcg ctc acc agc ctc aag atg ggg aag ctg gat gcc ttc       2334
Val Glu Asp Ala Leu Thr Ser Leu Lys Met Gly Lys Leu Asp Ala Phe           
                715                 720                 725               

atc tat gat gct gct gtc ctc aac tac atg gca ggc aag gac gag ggc       2382
Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met Ala Gly Lys Asp Glu Gly           
            730                 735                 740                   

tgc aag ctg gtc acc att ggg tct ggc aag gtc ttt gct acc act ggc       2430
Cys Lys Leu Val Thr Ile Gly Ser Gly Lys Val Phe Ala Thr Thr Gly           
        745                 750                 755                       

tac ggc atc gcc atg cag aag gac tcc cac tgg aag cgg gcc ata gac       2478
Tyr Gly Ile Ala Met Gln Lys Asp Ser His Trp Lys Arg Ala Ile Asp           
    760                 765                 770                           

ctg gcg ctc ttg cag ttc ctg ggg gac gga gag aca cag aaa ctg gag       2526
Leu Ala Leu Leu Gln Phe Leu Gly Asp Gly Glu Thr Gln Lys Leu Glu           
775                 780                 785                 790           

aca gtg tgg ctc tca ggg atc tgc cag aat gag aag aac gag gtg atg       2574
Thr Val Trp Leu Ser Gly Ile Cys Gln Asn Glu Lys Asn Glu Val Met           
                795                 800                 805               

agc agc aag ctg gac atc gac aac atg gca ggc gtc ttc tac atg ctg       2622
Ser Ser Lys Leu Asp Ile Asp Asn Met Ala Gly Val Phe Tyr Met Leu           
            810                 815                 820                   

ctg gtg gcc atg ggg ctg gcc ctg ctg gtc ttc gcc tgg gag cac ctg       2670
Leu Val Ala Met Gly Leu Ala Leu Leu Val Phe Ala Trp Glu His Leu           
        825                 830                 835                       

gtc tac tgg aag ctg cgc cac tcg gtg ccc aac tca tcc cag ctg gac       2718
Val Tyr Trp Lys Leu Arg His Ser Val Pro Asn Ser Ser Gln Leu Asp           
    840                 845                 850                           

ttc ctg ctg gct ttc agc agg ggc atc tac agc tgc ttc agc ggg gtg       2766
Phe Leu Leu Ala Phe Ser Arg Gly Ile Tyr Ser Cys Phe Ser Gly Val           
855                 860                 865                 870           

cag agc ctc gcc agc cca ccg cgg cag gcc agc ccg gac ctc acg gcc       2814
Gln Ser Leu Ala Ser Pro Pro Arg Gln Ala Ser Pro Asp Leu Thr Ala           
                875                 880                 885               

agc tcg gcc cag gcc agc gtg ctc aag atg ctg cag gca gcc cgc gac       2862
Ser Ser Ala Gln Ala Ser Val Leu Lys Met Leu Gln Ala Ala Arg Asp           
            890                 895                 900                   

atg gtg acc acg gcg ggc gta agc agc tcc ctg gac cgc gcc act cgc       2910
Met Val Thr Thr Ala Gly Val Ser Ser Ser Leu Asp Arg Ala Thr Arg           
        905                 910                 915                       

acc atc gag aat tgg ggt ggc ggc cgc cgt gcg ccc cca ccg tcc ccc       2958
Thr Ile Glu Asn Trp Gly Gly Gly Arg Arg Ala Pro Pro Pro Ser Pro           
    920                 925                 930                           

tgc ccg acc ccg cgg tct ggc ccc agc cca tgc ctg ccc acc ccc gac       3006
Cys Pro Thr Pro Arg Ser Gly Pro Ser Pro Cys Leu Pro Thr Pro Asp           
935                 940                 945                 950           

ccg ccc cca gag ccg agc ccc acg ggc tgg gga ccg cca gac ggg ggt       3054
Pro Pro Pro Glu Pro Ser Pro Thr Gly Trp Gly Pro Pro Asp Gly Gly           
                955                 960                 965               

cgc gcg gcg ctt gtg cgc agg gct ccg cag ccc ccg ggc cgc ccc ccg       3102
Arg Ala Ala Leu Val Arg Arg Ala Pro Gln Pro Pro Gly Arg Pro Pro           
            970                 975                 980                   

acg ccg ggg ccg ccc ctg tcc gac gtc tcc cga gtg tcg cgc cgc cca       3150
Thr Pro Gly Pro Pro Leu Ser Asp Val Ser Arg Val Ser Arg Arg Pro           
        985                 990                 995                       

gcc tgg  gag gcg cgg tgg ccg  gtg cgg acc ggg cac  tgc ggg agg        3195
Ala Trp  Glu Ala Arg Trp Pro  Val Arg Thr Gly His  Cys Gly Arg            
    1000                 1005                 1010                        

cac ctc  tcg gcc tcc gag cgg  ccc ctg tcg ccc gcg  cgc tgt cac        3240
His Leu  Ser Ala Ser Glu Arg  Pro Leu Ser Pro Ala  Arg Cys His            
    1015                 1020                 1025                        

tac agc  tcc ttt cct cga gcc  gac cga tcc ggc cgc  ccc ttc ctc        3285
Tyr Ser  Ser Phe Pro Arg Ala  Asp Arg Ser Gly Arg  Pro Phe Leu            
    1030                 1035                 1040                        

ccg ctc  ttc ccg gag ctg gag  gac ctg ccg ctg ctc  ggt ccg gag        3330
Pro Leu  Phe Pro Glu Leu Glu  Asp Leu Pro Leu Leu  Gly Pro Glu            
    1045                 1050                 1055                        

cag ctg  gcc cgg cgg gag gcc  ctg ctg cac gcg gcc  tgg gcc cgg        3375
Gln Leu  Ala Arg Arg Glu Ala  Leu Leu His Ala Ala  Trp Ala Arg            
    1060                 1065                 1070                        

ggc tcg  cgc ccg cgt cac gct  tcc ctg ccc agc tcc  gtg gcc gag        3420
Gly Ser  Arg Pro Arg His Ala  Ser Leu Pro Ser Ser  Val Ala Glu            
    1075                 1080                 1085                        

gcc ttc  gct cgg ccc agc tcg  ctg ccc gct ggg tgc  acc ggc ccc        3465
Ala Phe  Ala Arg Pro Ser Ser  Leu Pro Ala Gly Cys  Thr Gly Pro            
    1090                 1095                 1100                        

gcc tgc  gcc cgc ccc gac ggc  cac tcg gcc tgc agg  cgc ttg gcg        3510
Ala Cys  Ala Arg Pro Asp Gly  His Ser Ala Cys Arg  Arg Leu Ala            
    1105                 1110                 1115                        

cag gcg  cag tcg atg tgc ttg  ccg atc tac cgg gag  gcc tgc cag        3555
Gln Ala  Gln Ser Met Cys Leu  Pro Ile Tyr Arg Glu  Ala Cys Gln            
    1120                 1125                 1130                        

gag ggc  gag cag gca ggg gcc  ccc gcc tgg cag cac  aga cag cac        3600
Glu Gly  Glu Gln Ala Gly Ala  Pro Ala Trp Gln His  Arg Gln His            
    1135                 1140                 1145                        

gtc tgc  ctg cac gcc cac gcc  cac ctg cca ttt tgc  tgg ggg gct        3645
Val Cys  Leu His Ala His Ala  His Leu Pro Phe Cys  Trp Gly Ala            
    1150                 1155                 1160                        

gtc tgt  cct cac ctt cca ccc  tgt gcc agc cac ggc  tcc tgg ctc        3690
Val Cys  Pro His Leu Pro Pro  Cys Ala Ser His Gly  Ser Trp Leu            
    1165                 1170                 1175                        

tcc ggg  gcc tgg ggg cct ctg  ggg cac agg ggc agg  act ctg ggg        3735
Ser Gly  Ala Trp Gly Pro Leu  Gly His Arg Gly Arg  Thr Leu Gly            
    1180                 1185                 1190                        

ctg ggc  aca ggc tac aga gac  agt ggg gga ctg gac  gag atc agc        3780
Leu Gly  Thr Gly Tyr Arg Asp  Ser Gly Gly Leu Asp  Glu Ile Ser            
    1195                 1200                 1205                        

agg gta  gcc cgt ggg acg caa  ggc ttc ccg gga ccc  tgc acc tgg        3825
Arg Val  Ala Arg Gly Thr Gln  Gly Phe Pro Gly Pro  Cys Thr Trp            
    1210                 1215                 1220                        

aga cgg  atc tcc agt ctg gag  tca gaa gtg tga gttatcagcc              3868
Arg Arg  Ile Ser Ser Leu Glu  Ser Glu Val                                 
    1225                 1230                                             

actcaggctc cgagccagct ggattctctg cctgccactg tcagggttaa gcggcaggca     3928

ggattgggct tttctggctt ctaccatgaa atcctggcca tgggacccca gtgacagatg     3988

atgtcttcca tggtcatcag tgacctcagt agcctcaaat catggtgagg gctgggcttt     4048

tgctgtcctc ttctcacgca gagttctgcc aggagggtgt gctgtggggg tcagactcct     4108

gaggctctcc cttccctggg gctagccagt tactggtcat ggctgctgtg ggcatggagg     4168

ctggaacttg tggttgaggc agggccatcc cgatccttgc tctacctggc tagagtttct     4228

tctcatcaga gcactgggac attaaaccca ccttttccca gaaaaaaaaa aaaaaaaaaa     4288

aaaaaaaaaa                                                            4298


<210>  774
<211>  1233
<212>  PRT
<213>  Homo sapiens

<400>  774

Met Gly Gly Ala Leu Gly Pro Ala Leu Leu Leu Thr Ser Leu Phe Gly 
1               5                   10                  15      


Ala Trp Ala Gly Leu Gly Pro Gly Gln Gly Glu Gln Gly Met Thr Val 
            20                  25                  30          


Ala Val Val Phe Ser Ser Ser Gly Pro Pro Gln Ala Gln Phe Arg Ala 
        35                  40                  45              


Arg Leu Thr Pro Gln Ser Phe Leu Asp Leu Pro Leu Glu Ile Gln Pro 
    50                  55                  60                  


Leu Thr Val Gly Val Asn Thr Thr Asn Pro Ser Ser Leu Leu Thr Gln 
65                  70                  75                  80  


Ile Cys Gly Leu Leu Gly Ala Ala His Val His Gly Ile Val Phe Glu 
                85                  90                  95      


Asp Asn Val Asp Thr Glu Ala Val Ala Gln Ile Leu Asp Phe Ile Ser 
            100                 105                 110         


Ser Gln Thr His Val Pro Ile Leu Ser Ile Ser Gly Gly Ser Ala Val 
        115                 120                 125             


Val Leu Thr Pro Lys Glu Pro Gly Ser Ala Phe Leu Gln Leu Gly Val 
    130                 135                 140                 


Ser Leu Glu Gln Gln Leu Gln Val Leu Phe Lys Val Leu Glu Glu Tyr 
145                 150                 155                 160 


Asp Trp Ser Ala Phe Ala Val Ile Thr Ser Leu His Pro Gly His Ala 
                165                 170                 175     


Leu Phe Leu Glu Gly Val Arg Ala Val Ala Asp Ala Ser His Val Ser 
            180                 185                 190         


Trp Arg Leu Leu Asp Val Val Thr Leu Glu Leu Gly Pro Gly Gly Pro 
        195                 200                 205             


Arg Ala Arg Thr Gln Arg Leu Leu Arg Gln Leu Asp Ala Pro Val Phe 
    210                 215                 220                 


Val Ala Tyr Cys Ser Arg Glu Glu Ala Glu Val Leu Phe Ala Glu Ala 
225                 230                 235                 240 


Ala Gln Ala Gly Leu Val Gly Pro Gly His Val Trp Leu Val Pro Asn 
                245                 250                 255     


Leu Ala Leu Gly Ser Thr Asp Ala Pro Pro Ala Thr Phe Pro Val Gly 
            260                 265                 270         


Leu Ile Ser Val Val Thr Glu Ser Trp Arg Leu Ser Leu Arg Gln Lys 
        275                 280                 285             


Val Arg Asp Gly Val Ala Ile Leu Ala Leu Gly Ala His Ser Tyr Trp 
    290                 295                 300                 


Arg Gln His Gly Thr Leu Pro Ala Pro Ala Gly Asp Cys Arg Val His 
305                 310                 315                 320 


Pro Gly Pro Val Ser Pro Ala Arg Glu Ala Phe Tyr Arg His Leu Leu 
                325                 330                 335     


Asn Val Thr Trp Glu Gly Arg Asp Phe Ser Phe Ser Pro Gly Gly Tyr 
            340                 345                 350         


Leu Val Gln Pro Thr Met Val Val Ile Ala Leu Asn Arg His Arg Leu 
        355                 360                 365             


Trp Glu Met Val Gly Arg Trp Glu His Gly Val Leu Tyr Met Lys Tyr 
    370                 375                 380                 


Pro Val Trp Pro Arg Tyr Ser Ala Ser Leu Gln Pro Val Val Asp Ser 
385                 390                 395                 400 


Arg His Leu Thr Val Ala Thr Leu Glu Glu Arg Pro Phe Val Ile Val 
                405                 410                 415     


Glu Ser Pro Asp Pro Gly Thr Gly Gly Cys Val Pro Asn Thr Val Pro 
            420                 425                 430         


Cys Arg Arg Gln Ser Asn His Thr Phe Ser Ser Gly Asp Val Ala Pro 
        435                 440                 445             


Tyr Thr Lys Leu Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu Lys Lys 
    450                 455                 460                 


Leu Ala Arg Val Val Lys Phe Ser Tyr Asp Leu Tyr Leu Val Thr Asn 
465                 470                 475                 480 


Gly Lys His Gly Lys Arg Val Arg Gly Val Trp Asn Gly Met Ile Gly 
                485                 490                 495     


Glu Val Tyr Tyr Lys Arg Ala Asp Met Ala Ile Gly Ser Leu Thr Ile 
            500                 505                 510         


Asn Glu Glu Arg Ser Glu Ile Val Asp Phe Ser Val Pro Phe Val Glu 
        515                 520                 525             


Thr Gly Ile Ser Val Met Val Ala Arg Ser Asn Gly Thr Val Ser Pro 
    530                 535                 540                 


Ser Ala Phe Leu Glu Pro Tyr Ser Pro Ala Val Trp Val Met Met Phe 
545                 550                 555                 560 


Val Met Cys Leu Thr Val Val Ala Ile Thr Val Phe Met Phe Glu Tyr 
                565                 570                 575     


Phe Ser Pro Val Ser Tyr Asn Gln Asn Leu Thr Arg Gly Lys Lys Ser 
            580                 585                 590         


Gly Gly Pro Ala Phe Thr Ile Gly Lys Ser Val Trp Leu Leu Trp Ala 
        595                 600                 605             


Leu Val Phe Asn Asn Ser Val Pro Ile Glu Asn Pro Arg Gly Thr Thr 
    610                 615                 620                 


Ser Lys Ile Met Val Leu Val Trp Ala Phe Phe Ala Val Ile Phe Leu 
625                 630                 635                 640 


Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu Gln Tyr 
                645                 650                 655     


Ile Asp Thr Val Ser Gly Leu Ser Asp Lys Lys Phe Gln Arg Pro Gln 
            660                 665                 670         


Asp Gln Tyr Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly Ser Thr 
        675                 680                 685             


Glu Arg Asn Ile Arg Ser Asn Tyr Arg Asp Met His Thr His Met Val 
    690                 695                 700                 


Lys Phe Asn Gln Arg Ser Val Glu Asp Ala Leu Thr Ser Leu Lys Met 
705                 710                 715                 720 


Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met 
                725                 730                 735     


Ala Gly Lys Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Lys 
            740                 745                 750         


Val Phe Ala Thr Thr Gly Tyr Gly Ile Ala Met Gln Lys Asp Ser His 
        755                 760                 765             


Trp Lys Arg Ala Ile Asp Leu Ala Leu Leu Gln Phe Leu Gly Asp Gly 
    770                 775                 780                 


Glu Thr Gln Lys Leu Glu Thr Val Trp Leu Ser Gly Ile Cys Gln Asn 
785                 790                 795                 800 


Glu Lys Asn Glu Val Met Ser Ser Lys Leu Asp Ile Asp Asn Met Ala 
                805                 810                 815     


Gly Val Phe Tyr Met Leu Leu Val Ala Met Gly Leu Ala Leu Leu Val 
            820                 825                 830         


Phe Ala Trp Glu His Leu Val Tyr Trp Lys Leu Arg His Ser Val Pro 
        835                 840                 845             


Asn Ser Ser Gln Leu Asp Phe Leu Leu Ala Phe Ser Arg Gly Ile Tyr 
    850                 855                 860                 


Ser Cys Phe Ser Gly Val Gln Ser Leu Ala Ser Pro Pro Arg Gln Ala 
865                 870                 875                 880 


Ser Pro Asp Leu Thr Ala Ser Ser Ala Gln Ala Ser Val Leu Lys Met 
                885                 890                 895     


Leu Gln Ala Ala Arg Asp Met Val Thr Thr Ala Gly Val Ser Ser Ser 
            900                 905                 910         


Leu Asp Arg Ala Thr Arg Thr Ile Glu Asn Trp Gly Gly Gly Arg Arg 
        915                 920                 925             


Ala Pro Pro Pro Ser Pro Cys Pro Thr Pro Arg Ser Gly Pro Ser Pro 
    930                 935                 940                 


Cys Leu Pro Thr Pro Asp Pro Pro Pro Glu Pro Ser Pro Thr Gly Trp 
945                 950                 955                 960 


Gly Pro Pro Asp Gly Gly Arg Ala Ala Leu Val Arg Arg Ala Pro Gln 
                965                 970                 975     


Pro Pro Gly Arg Pro Pro Thr Pro Gly Pro Pro Leu Ser Asp Val Ser 
            980                 985                 990         


Arg Val Ser Arg Arg Pro Ala Trp  Glu Ala Arg Trp Pro  Val Arg Thr 
        995                 1000                 1005             


Gly His  Cys Gly Arg His Leu  Ser Ala Ser Glu Arg  Pro Leu Ser 
    1010                 1015                 1020             


Pro Ala  Arg Cys His Tyr Ser  Ser Phe Pro Arg Ala  Asp Arg Ser 
    1025                 1030                 1035             


Gly Arg  Pro Phe Leu Pro Leu  Phe Pro Glu Leu Glu  Asp Leu Pro 
    1040                 1045                 1050             


Leu Leu  Gly Pro Glu Gln Leu  Ala Arg Arg Glu Ala  Leu Leu His 
    1055                 1060                 1065             


Ala Ala  Trp Ala Arg Gly Ser  Arg Pro Arg His Ala  Ser Leu Pro 
    1070                 1075                 1080             


Ser Ser  Val Ala Glu Ala Phe  Ala Arg Pro Ser Ser  Leu Pro Ala 
    1085                 1090                 1095             


Gly Cys  Thr Gly Pro Ala Cys  Ala Arg Pro Asp Gly  His Ser Ala 
    1100                 1105                 1110             


Cys Arg  Arg Leu Ala Gln Ala  Gln Ser Met Cys Leu  Pro Ile Tyr 
    1115                 1120                 1125             


Arg Glu  Ala Cys Gln Glu Gly  Glu Gln Ala Gly Ala  Pro Ala Trp 
    1130                 1135                 1140             


Gln His  Arg Gln His Val Cys  Leu His Ala His Ala  His Leu Pro 
    1145                 1150                 1155             


Phe Cys  Trp Gly Ala Val Cys  Pro His Leu Pro Pro  Cys Ala Ser 
    1160                 1165                 1170             


His Gly  Ser Trp Leu Ser Gly  Ala Trp Gly Pro Leu  Gly His Arg 
    1175                 1180                 1185             


Gly Arg  Thr Leu Gly Leu Gly  Thr Gly Tyr Arg Asp  Ser Gly Gly 
    1190                 1195                 1200             


Leu Asp  Glu Ile Ser Arg Val  Ala Arg Gly Thr Gln  Gly Phe Pro 
    1205                 1210                 1215             


Gly Pro  Cys Thr Trp Arg Arg  Ile Ser Ser Leu Glu  Ser Glu Val 
    1220                 1225                 1230             


<210>  775
<211>  3411
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (101)..(2809)

<400>  775
cttctcttgt gtaatcagct gcctatttgg aaattgggca gggtttgcga ctggatgcta       60

atgtcactga ctagttttca gcctaccatc cagaagtaac atg ttc cca gct ttg        115
                                            Met Phe Pro Ala Leu           
                                            1               5             

gaa acg cac cta aag cag act att cct gat cct tat gaa gac ttt atg        163
Glu Thr His Leu Lys Gln Thr Ile Pro Asp Pro Tyr Glu Asp Phe Met           
                10                  15                  20                

tac cgt cac ctc caa tat tat ggc tac ttt aaa gct cag aga ggc agt        211
Tyr Arg His Leu Gln Tyr Tyr Gly Tyr Phe Lys Ala Gln Arg Gly Ser           
            25                  30                  35                    

tta cca aac tct gct acg cat cag cat gtt cgg aag aat aac cct caa        259
Leu Pro Asn Ser Ala Thr His Gln His Val Arg Lys Asn Asn Pro Gln           
        40                  45                  50                        

tgc ctg ttg aat ggc tct ctt ggg gaa aaa gat gat ttg ata cca gac        307
Cys Leu Leu Asn Gly Ser Leu Gly Glu Lys Asp Asp Leu Ile Pro Asp           
    55                  60                  65                            

acc ctg caa aag gag aag ctt cta tgg cct atc agt tta tct tca gct        355
Thr Leu Gln Lys Glu Lys Leu Leu Trp Pro Ile Ser Leu Ser Ser Ala           
70                  75                  80                  85            

gtg cac aga cag ata gaa gcc atc aac aga gac ttt cac tct tgc ctg        403
Val His Arg Gln Ile Glu Ala Ile Asn Arg Asp Phe His Ser Cys Leu           
                90                  95                  100               

ggc tgg atg cag tgg cgc ggc ctc agc tca ctg caa cct cca cct ccc        451
Gly Trp Met Gln Trp Arg Gly Leu Ser Ser Leu Gln Pro Pro Pro Pro           
            105                 110                 115                   

aga ttc aag gat tct cct gcc tca gct ttc cga gta gct ggg att aca        499
Arg Phe Lys Asp Ser Pro Ala Ser Ala Phe Arg Val Ala Gly Ile Thr           
        120                 125                 130                       

gat tca cat atg ctg agt tta cca cat ctt agg agc aga cag ctt ctt        547
Asp Ser His Met Leu Ser Leu Pro His Leu Arg Ser Arg Gln Leu Leu           
    135                 140                 145                           

tat gat gag ttg gat gaa gta aac cca cgt ctt cga gaa ccc caa gag        595
Tyr Asp Glu Leu Asp Glu Val Asn Pro Arg Leu Arg Glu Pro Gln Glu           
150                 155                 160                 165           

ctc ttt tcc att ttg tct acc aag agg cca ctg cag gct cca aga tgg        643
Leu Phe Ser Ile Leu Ser Thr Lys Arg Pro Leu Gln Ala Pro Arg Trp           
                170                 175                 180               

cca att gaa tgt gag gtc atc aag gaa aac atc cat cat att gag tgg        691
Pro Ile Glu Cys Glu Val Ile Lys Glu Asn Ile His His Ile Glu Trp           
            185                 190                 195                   

gct cca cct caa cca gaa tat ttc tat cag cct aaa gga aat gaa aag        739
Ala Pro Pro Gln Pro Glu Tyr Phe Tyr Gln Pro Lys Gly Asn Glu Lys           
        200                 205                 210                       

gta cca gag att gta gga gag aaa aaa gga aca gtt gtc tat caa tta        787
Val Pro Glu Ile Val Gly Glu Lys Lys Gly Thr Val Val Tyr Gln Leu           
    215                 220                 225                           

gat tca gtg cct ata gaa ggt tcc tat ttt acc agt tcc aga gtg gga        835
Asp Ser Val Pro Ile Glu Gly Ser Tyr Phe Thr Ser Ser Arg Val Gly           
230                 235                 240                 245           

ggc aaa cga gga att gtc aag gaa ctt gct gtc acg ttg caa gga cca        883
Gly Lys Arg Gly Ile Val Lys Glu Leu Ala Val Thr Leu Gln Gly Pro           
                250                 255                 260               

gaa gat aat act cta ctg ttt gaa tca agg ttt gag agt ggg aat ctg        931
Glu Asp Asn Thr Leu Leu Phe Glu Ser Arg Phe Glu Ser Gly Asn Leu           
            265                 270                 275                   

caa aaa gct gtc aga gta gac acc tat gag tat gaa ctc acc ttg cga        979
Gln Lys Ala Val Arg Val Asp Thr Tyr Glu Tyr Glu Leu Thr Leu Arg           
        280                 285                 290                       

act gac ctc tac act aac aaa cac act cag tgg ttt tat ttt cgt gtt       1027
Thr Asp Leu Tyr Thr Asn Lys His Thr Gln Trp Phe Tyr Phe Arg Val           
    295                 300                 305                           

cag aac acc aga aaa gat gct acc tat cgc ttc acc att gtc aac ttg       1075
Gln Asn Thr Arg Lys Asp Ala Thr Tyr Arg Phe Thr Ile Val Asn Leu           
310                 315                 320                 325           

cta aaa ccc aag agt ctt tat act gta ggg atg aag cca ctc ttg tac       1123
Leu Lys Pro Lys Ser Leu Tyr Thr Val Gly Met Lys Pro Leu Leu Tyr           
                330                 335                 340               

tcc caa ttg gat gcc aac acc cgc aat att ggc tgg agg aga gaa gga       1171
Ser Gln Leu Asp Ala Asn Thr Arg Asn Ile Gly Trp Arg Arg Glu Gly           
            345                 350                 355                   

aat gaa atc aag tac tac aag aac aac acg gat gat ggg cag cag ccc       1219
Asn Glu Ile Lys Tyr Tyr Lys Asn Asn Thr Asp Asp Gly Gln Gln Pro           
        360                 365                 370                       

ttc tac tgt ctc acg tgg acc att cag ttt cca tat gac cag gac act       1267
Phe Tyr Cys Leu Thr Trp Thr Ile Gln Phe Pro Tyr Asp Gln Asp Thr           
    375                 380                 385                           

tgc ttc ttt gca cac ttc tac cca tat aca tac act gat ttg caa tgc       1315
Cys Phe Phe Ala His Phe Tyr Pro Tyr Thr Tyr Thr Asp Leu Gln Cys           
390                 395                 400                 405           

tac ctc ctg tca gtg gca aac aac cct atc cag tct cag ttc tgc aag       1363
Tyr Leu Leu Ser Val Ala Asn Asn Pro Ile Gln Ser Gln Phe Cys Lys           
                410                 415                 420               

ctc caa act tta tgc agg agc cta gca gga aat acc gtt tac ttg ctc       1411
Leu Gln Thr Leu Cys Arg Ser Leu Ala Gly Asn Thr Val Tyr Leu Leu           
            425                 430                 435                   

acc atc acc aac cca tcc cag acc cct caa gag gca gct gca aag aaa       1459
Thr Ile Thr Asn Pro Ser Gln Thr Pro Gln Glu Ala Ala Ala Lys Lys           
        440                 445                 450                       

gct gtg gtc ttg agt gcc aga gtt cac cct gga gaa agt aat ggc tcc       1507
Ala Val Val Leu Ser Ala Arg Val His Pro Gly Glu Ser Asn Gly Ser           
    455                 460                 465                           

tgg gtt atg aaa ggc ttt ttg gac ttc atc ctt agc aac tcc cca gat       1555
Trp Val Met Lys Gly Phe Leu Asp Phe Ile Leu Ser Asn Ser Pro Asp           
470                 475                 480                 485           

gcc cag ctc ctc aga gat att ttt gtc ttc aag gtg ctt ccc atg tta       1603
Ala Gln Leu Leu Arg Asp Ile Phe Val Phe Lys Val Leu Pro Met Leu           
                490                 495                 500               

aat cca gat ggt gtg att gtg ggg aat tat cgg tgt tcc ttg gcc gga       1651
Asn Pro Asp Gly Val Ile Val Gly Asn Tyr Arg Cys Ser Leu Ala Gly           
            505                 510                 515                   

agg gat ttg aac agg cat tat aaa acc att ctg aag gag tct ttc cct       1699
Arg Asp Leu Asn Arg His Tyr Lys Thr Ile Leu Lys Glu Ser Phe Pro           
        520                 525                 530                       

tgt att tgg tac acc agg aac atg atc aaa aga ctt ctt gaa gaa aga       1747
Cys Ile Trp Tyr Thr Arg Asn Met Ile Lys Arg Leu Leu Glu Glu Arg           
    535                 540                 545                           

gag gtt ctg ttg tat tgt gat ttc cat ggc cac agt cgt aag aat aat       1795
Glu Val Leu Leu Tyr Cys Asp Phe His Gly His Ser Arg Lys Asn Asn           
550                 555                 560                 565           

atc ttc ctg tat ggc tgt aat aac aac aat cgc aaa tac tgg ctt cat       1843
Ile Phe Leu Tyr Gly Cys Asn Asn Asn Asn Arg Lys Tyr Trp Leu His           
                570                 575                 580               

gaa cga gtc ttt cct tta atg tta tgc aaa aat gca cca gat aag ttc       1891
Glu Arg Val Phe Pro Leu Met Leu Cys Lys Asn Ala Pro Asp Lys Phe           
            585                 590                 595                   

tct ttt cac agt tgt aat ttt aag gtc caa aaa tgc aaa gaa gga aca       1939
Ser Phe His Ser Cys Asn Phe Lys Val Gln Lys Cys Lys Glu Gly Thr           
        600                 605                 610                       

gga cga gtt gtt atg tgg cgg atg gga atc cta aac agc tac acc atg       1987
Gly Arg Val Val Met Trp Arg Met Gly Ile Leu Asn Ser Tyr Thr Met           
    615                 620                 625                           

gag tct acc ttt ggc ggg tcc acc ctg ggt aat aaa aga gac acc cac       2035
Glu Ser Thr Phe Gly Gly Ser Thr Leu Gly Asn Lys Arg Asp Thr His           
630                 635                 640                 645           

ttt acc atc gaa gat ctg aag tcc tta ggt tat cat gtc tgt gac acc       2083
Phe Thr Ile Glu Asp Leu Lys Ser Leu Gly Tyr His Val Cys Asp Thr           
                650                 655                 660               

ctt ctg gac ttt tgt gat cct gac caa atg aag ttc act cag tgt cta       2131
Leu Leu Asp Phe Cys Asp Pro Asp Gln Met Lys Phe Thr Gln Cys Leu           
            665                 670                 675                   

gca gag ctt aag gag ctt tta cga cag gaa atc cac aag aaa ttc cat       2179
Ala Glu Leu Lys Glu Leu Leu Arg Gln Glu Ile His Lys Lys Phe His           
        680                 685                 690                       

gaa ctt gga caa gat gta gat tta gaa gga agt tgg agt gac atc tct       2227
Glu Leu Gly Gln Asp Val Asp Leu Glu Gly Ser Trp Ser Asp Ile Ser           
    695                 700                 705                           

ttg tct gac att gaa tcc agc acc agt ggc tct gac agt tct ctc tca       2275
Leu Ser Asp Ile Glu Ser Ser Thr Ser Gly Ser Asp Ser Ser Leu Ser           
710                 715                 720                 725           

gat ggt ctt cct gtt cac cta gca aac ata gca gat gag ctg act cag       2323
Asp Gly Leu Pro Val His Leu Ala Asn Ile Ala Asp Glu Leu Thr Gln           
                730                 735                 740               

aaa aag aag atg ttt aag aag aaa aaa aag aag tca ctt cag act agg       2371
Lys Lys Lys Met Phe Lys Lys Lys Lys Lys Lys Ser Leu Gln Thr Arg           
            745                 750                 755                   

aaa cag cga aat gag cag tat cag aaa aaa aat ttg atg cag aag tta       2419
Lys Gln Arg Asn Glu Gln Tyr Gln Lys Lys Asn Leu Met Gln Lys Leu           
        760                 765                 770                       

aag tta aca gaa gat acc tca gaa aag gca gga ttt gct tct act ctg       2467
Lys Leu Thr Glu Asp Thr Ser Glu Lys Ala Gly Phe Ala Ser Thr Leu           
    775                 780                 785                           

caa aag cag cca acc ttt ttc aaa aac tca gag aat tcc agt ttt tta       2515
Gln Lys Gln Pro Thr Phe Phe Lys Asn Ser Glu Asn Ser Ser Phe Leu           
790                 795                 800                 805           

cca atg aaa aat gaa aac cca agg tta aat gag aca aat tta aat aga       2563
Pro Met Lys Asn Glu Asn Pro Arg Leu Asn Glu Thr Asn Leu Asn Arg           
                810                 815                 820               

aga gac aaa gac acc ccc ctg gac cca tca atg gcc acc ctg att ctg       2611
Arg Asp Lys Asp Thr Pro Leu Asp Pro Ser Met Ala Thr Leu Ile Leu           
            825                 830                 835                   

cct aag aat aaa ggg aga atg cag aat aag aag cca ggc ttt aca gta       2659
Pro Lys Asn Lys Gly Arg Met Gln Asn Lys Lys Pro Gly Phe Thr Val           
        840                 845                 850                       

tca tgc tct cca aag aga acc ata aac tcc agc caa gag cca gct cca       2707
Ser Cys Ser Pro Lys Arg Thr Ile Asn Ser Ser Gln Glu Pro Ala Pro           
    855                 860                 865                           

ggt atg aag cca aac tgg cct agg agc aga tat cct gcc aca aag aga       2755
Gly Met Lys Pro Asn Trp Pro Arg Ser Arg Tyr Pro Ala Thr Lys Arg           
870                 875                 880                 885           

ggc tgt gct gcc atg gcg gca tac cca tcc ttg cac ata tac aca tac       2803
Gly Cys Ala Ala Met Ala Ala Tyr Pro Ser Leu His Ile Tyr Thr Tyr           
                890                 895                 900               

ccg tag gtgagcctgg gctgtgccac acaagcactt catcgggggt tttgagatta        2859
Pro                                                                       
                                                                          

gacacatttt ataatggggg agatgtatga ctgggaactg catttacttg tggtatactg     2919

tgttgtgcac tcatgcactg accttacact ttgtacttac actgtgggca tgtggtcaag     2979

atgcatacct catgaattca actatttttt cataaaatga aattttatta tgatgtgtaa     3039

aaatgcttta tcagaaactg aagtgtgttc tcatggcaca cttcatggca gcacagatat     3099

acctcatttt aaccaataga tattctctct aaaattatgt gcaaatcaat ttttaaaaat     3159

caaaatctat gttaaacaca ttttggcagt gtgctataat aaaaaaaagt gttgtgtcaa     3219

agctttctag tgacggtcag tcctactgct gtatgtcagg tttgctcaca atgaggtatt     3279

cccacataga aataacaatg catgtattac ccagaattta atgttgcgta ccttatgttc     3339

aatgaggttt tgtaattttt ttaggctgat gattaaaatt ctttctctct aaaaaaaaaa     3399

aaaaaaaaaa aa                                                         3411


<210>  776
<211>  902
<212>  PRT
<213>  Homo sapiens

<400>  776

Met Phe Pro Ala Leu Glu Thr His Leu Lys Gln Thr Ile Pro Asp Pro 
1               5                   10                  15      


Tyr Glu Asp Phe Met Tyr Arg His Leu Gln Tyr Tyr Gly Tyr Phe Lys 
            20                  25                  30          


Ala Gln Arg Gly Ser Leu Pro Asn Ser Ala Thr His Gln His Val Arg 
        35                  40                  45              


Lys Asn Asn Pro Gln Cys Leu Leu Asn Gly Ser Leu Gly Glu Lys Asp 
    50                  55                  60                  


Asp Leu Ile Pro Asp Thr Leu Gln Lys Glu Lys Leu Leu Trp Pro Ile 
65                  70                  75                  80  


Ser Leu Ser Ser Ala Val His Arg Gln Ile Glu Ala Ile Asn Arg Asp 
                85                  90                  95      


Phe His Ser Cys Leu Gly Trp Met Gln Trp Arg Gly Leu Ser Ser Leu 
            100                 105                 110         


Gln Pro Pro Pro Pro Arg Phe Lys Asp Ser Pro Ala Ser Ala Phe Arg 
        115                 120                 125             


Val Ala Gly Ile Thr Asp Ser His Met Leu Ser Leu Pro His Leu Arg 
    130                 135                 140                 


Ser Arg Gln Leu Leu Tyr Asp Glu Leu Asp Glu Val Asn Pro Arg Leu 
145                 150                 155                 160 


Arg Glu Pro Gln Glu Leu Phe Ser Ile Leu Ser Thr Lys Arg Pro Leu 
                165                 170                 175     


Gln Ala Pro Arg Trp Pro Ile Glu Cys Glu Val Ile Lys Glu Asn Ile 
            180                 185                 190         


His His Ile Glu Trp Ala Pro Pro Gln Pro Glu Tyr Phe Tyr Gln Pro 
        195                 200                 205             


Lys Gly Asn Glu Lys Val Pro Glu Ile Val Gly Glu Lys Lys Gly Thr 
    210                 215                 220                 


Val Val Tyr Gln Leu Asp Ser Val Pro Ile Glu Gly Ser Tyr Phe Thr 
225                 230                 235                 240 


Ser Ser Arg Val Gly Gly Lys Arg Gly Ile Val Lys Glu Leu Ala Val 
                245                 250                 255     


Thr Leu Gln Gly Pro Glu Asp Asn Thr Leu Leu Phe Glu Ser Arg Phe 
            260                 265                 270         


Glu Ser Gly Asn Leu Gln Lys Ala Val Arg Val Asp Thr Tyr Glu Tyr 
        275                 280                 285             


Glu Leu Thr Leu Arg Thr Asp Leu Tyr Thr Asn Lys His Thr Gln Trp 
    290                 295                 300                 


Phe Tyr Phe Arg Val Gln Asn Thr Arg Lys Asp Ala Thr Tyr Arg Phe 
305                 310                 315                 320 


Thr Ile Val Asn Leu Leu Lys Pro Lys Ser Leu Tyr Thr Val Gly Met 
                325                 330                 335     


Lys Pro Leu Leu Tyr Ser Gln Leu Asp Ala Asn Thr Arg Asn Ile Gly 
            340                 345                 350         


Trp Arg Arg Glu Gly Asn Glu Ile Lys Tyr Tyr Lys Asn Asn Thr Asp 
        355                 360                 365             


Asp Gly Gln Gln Pro Phe Tyr Cys Leu Thr Trp Thr Ile Gln Phe Pro 
    370                 375                 380                 


Tyr Asp Gln Asp Thr Cys Phe Phe Ala His Phe Tyr Pro Tyr Thr Tyr 
385                 390                 395                 400 


Thr Asp Leu Gln Cys Tyr Leu Leu Ser Val Ala Asn Asn Pro Ile Gln 
                405                 410                 415     


Ser Gln Phe Cys Lys Leu Gln Thr Leu Cys Arg Ser Leu Ala Gly Asn 
            420                 425                 430         


Thr Val Tyr Leu Leu Thr Ile Thr Asn Pro Ser Gln Thr Pro Gln Glu 
        435                 440                 445             


Ala Ala Ala Lys Lys Ala Val Val Leu Ser Ala Arg Val His Pro Gly 
    450                 455                 460                 


Glu Ser Asn Gly Ser Trp Val Met Lys Gly Phe Leu Asp Phe Ile Leu 
465                 470                 475                 480 


Ser Asn Ser Pro Asp Ala Gln Leu Leu Arg Asp Ile Phe Val Phe Lys 
                485                 490                 495     


Val Leu Pro Met Leu Asn Pro Asp Gly Val Ile Val Gly Asn Tyr Arg 
            500                 505                 510         


Cys Ser Leu Ala Gly Arg Asp Leu Asn Arg His Tyr Lys Thr Ile Leu 
        515                 520                 525             


Lys Glu Ser Phe Pro Cys Ile Trp Tyr Thr Arg Asn Met Ile Lys Arg 
    530                 535                 540                 


Leu Leu Glu Glu Arg Glu Val Leu Leu Tyr Cys Asp Phe His Gly His 
545                 550                 555                 560 


Ser Arg Lys Asn Asn Ile Phe Leu Tyr Gly Cys Asn Asn Asn Asn Arg 
                565                 570                 575     


Lys Tyr Trp Leu His Glu Arg Val Phe Pro Leu Met Leu Cys Lys Asn 
            580                 585                 590         


Ala Pro Asp Lys Phe Ser Phe His Ser Cys Asn Phe Lys Val Gln Lys 
        595                 600                 605             


Cys Lys Glu Gly Thr Gly Arg Val Val Met Trp Arg Met Gly Ile Leu 
    610                 615                 620                 


Asn Ser Tyr Thr Met Glu Ser Thr Phe Gly Gly Ser Thr Leu Gly Asn 
625                 630                 635                 640 


Lys Arg Asp Thr His Phe Thr Ile Glu Asp Leu Lys Ser Leu Gly Tyr 
                645                 650                 655     


His Val Cys Asp Thr Leu Leu Asp Phe Cys Asp Pro Asp Gln Met Lys 
            660                 665                 670         


Phe Thr Gln Cys Leu Ala Glu Leu Lys Glu Leu Leu Arg Gln Glu Ile 
        675                 680                 685             


His Lys Lys Phe His Glu Leu Gly Gln Asp Val Asp Leu Glu Gly Ser 
    690                 695                 700                 


Trp Ser Asp Ile Ser Leu Ser Asp Ile Glu Ser Ser Thr Ser Gly Ser 
705                 710                 715                 720 


Asp Ser Ser Leu Ser Asp Gly Leu Pro Val His Leu Ala Asn Ile Ala 
                725                 730                 735     


Asp Glu Leu Thr Gln Lys Lys Lys Met Phe Lys Lys Lys Lys Lys Lys 
            740                 745                 750         


Ser Leu Gln Thr Arg Lys Gln Arg Asn Glu Gln Tyr Gln Lys Lys Asn 
        755                 760                 765             


Leu Met Gln Lys Leu Lys Leu Thr Glu Asp Thr Ser Glu Lys Ala Gly 
    770                 775                 780                 


Phe Ala Ser Thr Leu Gln Lys Gln Pro Thr Phe Phe Lys Asn Ser Glu 
785                 790                 795                 800 


Asn Ser Ser Phe Leu Pro Met Lys Asn Glu Asn Pro Arg Leu Asn Glu 
                805                 810                 815     


Thr Asn Leu Asn Arg Arg Asp Lys Asp Thr Pro Leu Asp Pro Ser Met 
            820                 825                 830         


Ala Thr Leu Ile Leu Pro Lys Asn Lys Gly Arg Met Gln Asn Lys Lys 
        835                 840                 845             


Pro Gly Phe Thr Val Ser Cys Ser Pro Lys Arg Thr Ile Asn Ser Ser 
    850                 855                 860                 


Gln Glu Pro Ala Pro Gly Met Lys Pro Asn Trp Pro Arg Ser Arg Tyr 
865                 870                 875                 880 


Pro Ala Thr Lys Arg Gly Cys Ala Ala Met Ala Ala Tyr Pro Ser Leu 
                885                 890                 895     


His Ile Tyr Thr Tyr Pro 
            900         


<210>  777
<211>  8617
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (235)..(3729)

<400>  777
acgacggggg aggtgctgta cgtccaagat ggcggcgccc tgtaggctgg agggactgtg       60

aggtaaacag ctgaggggga ggagacggtg gtgaccatga aagacaccag gttgacagca      120

ctggaaactg aagtaccagt tgtcgctaga acagtttggt agtggcccca atgaagaacc      180

ttcagaacct gtagcacacg tcctggagcc agcacagcgc cttcgagcga gaga atg        237
                                                            Met           
                                                            1             

gcc caa caa gca aat gtc ggg gag ctt ctt gcc atg ctg gac tcc ccc        285
Ala Gln Gln Ala Asn Val Gly Glu Leu Leu Ala Met Leu Asp Ser Pro           
            5                   10                  15                    

atg ctg ggt gtg cgg gac gac gtg aca gct gtc ttt aaa gag aac ctc        333
Met Leu Gly Val Arg Asp Asp Val Thr Ala Val Phe Lys Glu Asn Leu           
        20                  25                  30                        

aat tct gac cgt ggc cct atg ctt gta aac acc ttg gtg gat tat tac        381
Asn Ser Asp Arg Gly Pro Met Leu Val Asn Thr Leu Val Asp Tyr Tyr           
    35                  40                  45                            

ctg gaa acc agc tct cag ccg gca ttg cac atc ctg acc acc ttg caa        429
Leu Glu Thr Ser Ser Gln Pro Ala Leu His Ile Leu Thr Thr Leu Gln           
50                  55                  60                  65            

gag cca cat gac aag cac ctc ttg gac agg att aac gaa tat gtg ggc        477
Glu Pro His Asp Lys His Leu Leu Asp Arg Ile Asn Glu Tyr Val Gly           
                70                  75                  80                

aaa gcc gcc act cgt tta tcc atc ctc tcg tta ctg ggt cat gtc ata        525
Lys Ala Ala Thr Arg Leu Ser Ile Leu Ser Leu Leu Gly His Val Ile           
            85                  90                  95                    

aga ctg cag cca tct tgg aag cat aag ctc tct caa gca cct ctt ttg        573
Arg Leu Gln Pro Ser Trp Lys His Lys Leu Ser Gln Ala Pro Leu Leu           
        100                 105                 110                       

cct tct tta cta aaa tgt ctc aag atg gac act gac gtc gtt gtc ctc        621
Pro Ser Leu Leu Lys Cys Leu Lys Met Asp Thr Asp Val Val Val Leu           
    115                 120                 125                           

aca aca ggc gtc ttg gtg ttg ata acc atg cta cca atg att cca cag        669
Thr Thr Gly Val Leu Val Leu Ile Thr Met Leu Pro Met Ile Pro Gln           
130                 135                 140                 145           

tct ggg aaa cag cat ctt ctt gat ttc ttt gac att ttt ggc cgt ctg        717
Ser Gly Lys Gln His Leu Leu Asp Phe Phe Asp Ile Phe Gly Arg Leu           
                150                 155                 160               

tca tca tgg tgc ctg aag aaa cca ggc cac gtg gcg gaa gtc tat ctc        765
Ser Ser Trp Cys Leu Lys Lys Pro Gly His Val Ala Glu Val Tyr Leu           
            165                 170                 175                   

gtc cat ctc cat gcc agt gtg tac gca ctc ttt cat cgc ctt tat gga        813
Val His Leu His Ala Ser Val Tyr Ala Leu Phe His Arg Leu Tyr Gly           
        180                 185                 190                       

atg tac cct tgc aac ttc gtc tcc ttt ttg cgt tct cat tac agt atg        861
Met Tyr Pro Cys Asn Phe Val Ser Phe Leu Arg Ser His Tyr Ser Met           
    195                 200                 205                           

aaa gaa aac ctg gag act ttt gaa gaa gtg gtc aag cca atg atg gag        909
Lys Glu Asn Leu Glu Thr Phe Glu Glu Val Val Lys Pro Met Met Glu           
210                 215                 220                 225           

cat gtg cga att cat ccg gaa tta gtg act gga tcc aag gac cat gaa        957
His Val Arg Ile His Pro Glu Leu Val Thr Gly Ser Lys Asp His Glu           
                230                 235                 240               

ctg gac cct cga agg tgg aag aga tta gaa act cat gat gtt gtg atc       1005
Leu Asp Pro Arg Arg Trp Lys Arg Leu Glu Thr His Asp Val Val Ile           
            245                 250                 255                   

gag tgt gcc aaa atc tct ctg gat ccc aca gaa gcc tca tat gaa gat       1053
Glu Cys Ala Lys Ile Ser Leu Asp Pro Thr Glu Ala Ser Tyr Glu Asp           
        260                 265                 270                       

ggc tat tct gtg tct cac caa atc tca gcc cgc ttt cct cat cgt tca       1101
Gly Tyr Ser Val Ser His Gln Ile Ser Ala Arg Phe Pro His Arg Ser           
    275                 280                 285                           

gcc gat gtc acc acc agc cct tat gct gac aca cag aat agc tat ggg       1149
Ala Asp Val Thr Thr Ser Pro Tyr Ala Asp Thr Gln Asn Ser Tyr Gly           
290                 295                 300                 305           

tgt gct act tct acc cct tac tcc acg tct cgg ctg atg ttg tta aat       1197
Cys Ala Thr Ser Thr Pro Tyr Ser Thr Ser Arg Leu Met Leu Leu Asn           
                310                 315                 320               

atg cca ggg cag cta cct cag act ctg agt tcc cca tcg aca cgg ctg       1245
Met Pro Gly Gln Leu Pro Gln Thr Leu Ser Ser Pro Ser Thr Arg Leu           
            325                 330                 335                   

ata act gaa cca cca caa gct act ctt tgg agc cca tct atg gtt tgt       1293
Ile Thr Glu Pro Pro Gln Ala Thr Leu Trp Ser Pro Ser Met Val Cys           
        340                 345                 350                       

ggt atg acc act cct cca act tct cct gga aat gtc cca cct gat ctg       1341
Gly Met Thr Thr Pro Pro Thr Ser Pro Gly Asn Val Pro Pro Asp Leu           
    355                 360                 365                           

tca cac cct tac agt aaa gtc ttt ggt aca act gca ggt gga aaa gga       1389
Ser His Pro Tyr Ser Lys Val Phe Gly Thr Thr Ala Gly Gly Lys Gly           
370                 375                 380                 385           

act cct ctg gga acc cca gca acc tct cct cct cca gcc cca ctc tgt       1437
Thr Pro Leu Gly Thr Pro Ala Thr Ser Pro Pro Pro Ala Pro Leu Cys           
                390                 395                 400               

cat tcg gat gac tac gtg cac att tca ctc ccc cag gcc aca gtc aca       1485
His Ser Asp Asp Tyr Val His Ile Ser Leu Pro Gln Ala Thr Val Thr           
            405                 410                 415                   

ccc ccc agg aag gaa gag aga atg gat tct gca aga cca tgt cta cac       1533
Pro Pro Arg Lys Glu Glu Arg Met Asp Ser Ala Arg Pro Cys Leu His           
        420                 425                 430                       

aga caa cac cat ctt ctg aat gac aga gga tca gaa gag cca cct ggc       1581
Arg Gln His His Leu Leu Asn Asp Arg Gly Ser Glu Glu Pro Pro Gly           
    435                 440                 445                           

agc aaa ggt tct gtc act cta agt gat ctt cca ggg ttt tta ggt gat       1629
Ser Lys Gly Ser Val Thr Leu Ser Asp Leu Pro Gly Phe Leu Gly Asp           
450                 455                 460                 465           

ctg gcc tct gaa gaa gat agt att gaa aaa gat aaa gaa gaa gct gca       1677
Leu Ala Ser Glu Glu Asp Ser Ile Glu Lys Asp Lys Glu Glu Ala Ala           
                470                 475                 480               

ata tct aga gaa ctt tct gag atc acc aca gca gag gca gag cct gtg       1725
Ile Ser Arg Glu Leu Ser Glu Ile Thr Thr Ala Glu Ala Glu Pro Val           
            485                 490                 495                   

gtt cct cga gga ggc ttt gac tct ccc ttt tac cga gac agt ctc cca       1773
Val Pro Arg Gly Gly Phe Asp Ser Pro Phe Tyr Arg Asp Ser Leu Pro           
        500                 505                 510                       

ggt tct cag cgg aag acc cac tcg gca gcc tcc agt tct cag ggc gcc       1821
Gly Ser Gln Arg Lys Thr His Ser Ala Ala Ser Ser Ser Gln Gly Ala           
    515                 520                 525                           

agc gtg aac cct gag cct tta cac tcc tcc ctg gac aag ctt ggg cct       1869
Ser Val Asn Pro Glu Pro Leu His Ser Ser Leu Asp Lys Leu Gly Pro           
530                 535                 540                 545           

gac aca cca aag caa gcc ttt act ccc ata gac ctg ccc tgc ggc agt       1917
Asp Thr Pro Lys Gln Ala Phe Thr Pro Ile Asp Leu Pro Cys Gly Ser           
                550                 555                 560               

gct gat gaa agc cct gcg gga gac agg gaa tgc cag act tct ttg gag       1965
Ala Asp Glu Ser Pro Ala Gly Asp Arg Glu Cys Gln Thr Ser Leu Glu           
            565                 570                 575                   

acc agt atc ttc act ccc agt cct tgt aaa att cca cct ccg acg aga       2013
Thr Ser Ile Phe Thr Pro Ser Pro Cys Lys Ile Pro Pro Pro Thr Arg           
        580                 585                 590                       

gtg ggc ttt gga agc ggg cag cct ccc ccg tat gat cat ctt ttt gag       2061
Val Gly Phe Gly Ser Gly Gln Pro Pro Pro Tyr Asp His Leu Phe Glu           
    595                 600                 605                           

gtg gca ttg cca aag aca gcc cat cat ttt gtc atc agg aag act gag       2109
Val Ala Leu Pro Lys Thr Ala His His Phe Val Ile Arg Lys Thr Glu           
610                 615                 620                 625           

gag ctg tta aag aaa gca aaa gga aac aca gag gaa gat ggt gtg ccc       2157
Glu Leu Leu Lys Lys Ala Lys Gly Asn Thr Glu Glu Asp Gly Val Pro           
                630                 635                 640               

tct acc tcc cca atg gaa gtg ctg gac aga ctg ata cag cag gga gca       2205
Ser Thr Ser Pro Met Glu Val Leu Asp Arg Leu Ile Gln Gln Gly Ala           
            645                 650                 655                   

gac gcg cac agc aag gag ctg aac aag ttg cct tta ccc agc aag tct       2253
Asp Ala His Ser Lys Glu Leu Asn Lys Leu Pro Leu Pro Ser Lys Ser           
        660                 665                 670                       

gtc gac tgg acc cac ttt gga ggc tct cct cct tca gat gag atc cgc       2301
Val Asp Trp Thr His Phe Gly Gly Ser Pro Pro Ser Asp Glu Ile Arg           
    675                 680                 685                           

acc ctc cga gac cag ttg ctt tta ctg cac aac cag tta ctc tat gag       2349
Thr Leu Arg Asp Gln Leu Leu Leu Leu His Asn Gln Leu Leu Tyr Glu           
690                 695                 700                 705           

cgt ttt aag agg cag cag cat gcc ctc cgg aac agg cgg ctc ctc cgc       2397
Arg Phe Lys Arg Gln Gln His Ala Leu Arg Asn Arg Arg Leu Leu Arg           
                710                 715                 720               

aag gtg atc aaa gca gca gct ctg gag gaa cat aat gct gcc atg aaa       2445
Lys Val Ile Lys Ala Ala Ala Leu Glu Glu His Asn Ala Ala Met Lys           
            725                 730                 735                   

gat cag ttg aag tta caa gag aag gac atc cag atg tgg aag gtt agt       2493
Asp Gln Leu Lys Leu Gln Glu Lys Asp Ile Gln Met Trp Lys Val Ser           
        740                 745                 750                       

ctg cag aaa gaa caa gct aga tac aat cag ctc cag gag cag cgt gac       2541
Leu Gln Lys Glu Gln Ala Arg Tyr Asn Gln Leu Gln Glu Gln Arg Asp           
    755                 760                 765                           

act atg gta acc aag ctc cac agc cag atc aga cag ctg cag cat gac       2589
Thr Met Val Thr Lys Leu His Ser Gln Ile Arg Gln Leu Gln His Asp           
770                 775                 780                 785           

cga gag gaa ttc tac aac cag agc cag gaa tta cag acg aag ctg gag       2637
Arg Glu Glu Phe Tyr Asn Gln Ser Gln Glu Leu Gln Thr Lys Leu Glu           
                790                 795                 800               

gac tgc agg aac atg att gcg gag ctg cgg ata gaa ctg aag aag gcc       2685
Asp Cys Arg Asn Met Ile Ala Glu Leu Arg Ile Glu Leu Lys Lys Ala           
            805                 810                 815                   

aac aac aag gtg tgt cac act gag ctg ctg ctc agt cag gtt tcc caa       2733
Asn Asn Lys Val Cys His Thr Glu Leu Leu Leu Ser Gln Val Ser Gln           
        820                 825                 830                       

aag ctc tca aac agt gag tcg gtc cag cag cag atg gag ttc ttg aac       2781
Lys Leu Ser Asn Ser Glu Ser Val Gln Gln Gln Met Glu Phe Leu Asn           
    835                 840                 845                           

agg cag ctg ttg gtt ctt ggg gag gtc aac gag ctc tat ttg gaa caa       2829
Arg Gln Leu Leu Val Leu Gly Glu Val Asn Glu Leu Tyr Leu Glu Gln           
850                 855                 860                 865           

ctg cag aac aag cac tca gat acc aca aag gaa gta gaa atg atg aaa       2877
Leu Gln Asn Lys His Ser Asp Thr Thr Lys Glu Val Glu Met Met Lys           
                870                 875                 880               

gcc gcc tat cgg aaa gag cta gaa aaa aac aga agc cat gtt ctc cag       2925
Ala Ala Tyr Arg Lys Glu Leu Glu Lys Asn Arg Ser His Val Leu Gln           
            885                 890                 895                   

cag act cag agg ctt gat acc tcc caa aaa cgg att ttg gaa ctg gaa       2973
Gln Thr Gln Arg Leu Asp Thr Ser Gln Lys Arg Ile Leu Glu Leu Glu           
        900                 905                 910                       

tct cac ctg gcc aag aaa gac cac ctt ctt ttg gaa cag aag aaa tat       3021
Ser His Leu Ala Lys Lys Asp His Leu Leu Leu Glu Gln Lys Lys Tyr           
    915                 920                 925                           

cta gag gat gtc aaa ctc cag gca aga gga cag ctg cag gcc gca gag       3069
Leu Glu Asp Val Lys Leu Gln Ala Arg Gly Gln Leu Gln Ala Ala Glu           
930                 935                 940                 945           

agc agg tat gag gct cag aaa agg ata acc cag gtg ttt gaa ttg gag       3117
Ser Arg Tyr Glu Ala Gln Lys Arg Ile Thr Gln Val Phe Glu Leu Glu           
                950                 955                 960               

atc tta gat tta tat ggc agg ttg gag aaa gat ggc ctc ctg aaa aaa       3165
Ile Leu Asp Leu Tyr Gly Arg Leu Glu Lys Asp Gly Leu Leu Lys Lys           
            965                 970                 975                   

ctt gaa gaa gaa aaa gca gaa gca gct gaa gca gca gaa gaa agg ctt       3213
Leu Glu Glu Glu Lys Ala Glu Ala Ala Glu Ala Ala Glu Glu Arg Leu           
        980                 985                 990                       

gac tgt tgt aat gac ggg tgc  tca gat tcc atg gta  ggg cac aat gaa     3261
Asp Cys Cys Asn Asp Gly Cys  Ser Asp Ser Met Val  Gly His Asn Glu         
    995                 1000                 1005                         

gag  gca tct ggc cac aac  ggt gag acc aag acc  ccc agg ccc agc        3306
Glu  Ala Ser Gly His Asn  Gly Glu Thr Lys Thr  Pro Arg Pro Ser            
1010                 1015                 1020                            

agc  gcc cgg ggc agt agt  gga agc aga ggt ggt  gga ggc agc agc        3351
Ser  Ala Arg Gly Ser Ser  Gly Ser Arg Gly Gly  Gly Gly Ser Ser            
1025                 1030                 1035                            

agc  agc agc agc gag ctt  tct acc cca gag aaa  ccc cca cac cag        3396
Ser  Ser Ser Ser Glu Leu  Ser Thr Pro Glu Lys  Pro Pro His Gln            
1040                 1045                 1050                            

agg  gca ggc cca ttc agc  agt cgg tgg gag acg  act atg gga gaa        3441
Arg  Ala Gly Pro Phe Ser  Ser Arg Trp Glu Thr  Thr Met Gly Glu            
1055                 1060                 1065                            

gcg  tct gcc agc atc ccc  acc act gtg ggc tca  ctt ccc agt tca        3486
Ala  Ser Ala Ser Ile Pro  Thr Thr Val Gly Ser  Leu Pro Ser Ser            
1070                 1075                 1080                            

aaa  agc ttc ctg ggt atg  aag gct cga gag tta  ttt cgt aat aag        3531
Lys  Ser Phe Leu Gly Met  Lys Ala Arg Glu Leu  Phe Arg Asn Lys            
1085                 1090                 1095                            

agc  gag agc cag tgt gat  gag gac ggc atg acc  agt agc ctt tct        3576
Ser  Glu Ser Gln Cys Asp  Glu Asp Gly Met Thr  Ser Ser Leu Ser            
1100                 1105                 1110                            

gag  agc cta aag aca gaa  ctg ggc aaa gac ttg  ggt gtg gaa gcc        3621
Glu  Ser Leu Lys Thr Glu  Leu Gly Lys Asp Leu  Gly Val Glu Ala            
1115                 1120                 1125                            

aag  att ccc ctg aac cta  gat ggc cct cac ccg  tct ccc ccg acc        3666
Lys  Ile Pro Leu Asn Leu  Asp Gly Pro His Pro  Ser Pro Pro Thr            
1130                 1135                 1140                            

ccg  gac agt gtt gga cag  cta cat atc atg gac  tac aat gag act        3711
Pro  Asp Ser Val Gly Gln  Leu His Ile Met Asp  Tyr Asn Glu Thr            
1145                 1150                 1155                            

cat  cat gaa cac agc taa ggaatgatgg tcaatcagtg ttaacttgca             3759
His  His Glu His Ser                                                      
1160                                                                      

tattgttggc acagaacagg aggtgtgaat gcacgtttca aagctttcct gtttccaggg     3819

tctgagtgca agttcatgtg tggaaatggg acggaggtcc tttggacagc tgactgaatg     3879

cagaacggtt tttggatctg gcattgaaat gcctcttgac cttcccctcc acccgcccta     3939

accccctctc atttacctcg cagtgtgttc taatccaagg gccagttggt gttcctcagt     3999

agctttactt tcttcctttc ccccccaaat ggttgcgtcc tttgaacctg tgcaatatga     4059

ggccaaattt aatctttgag tctaacacac cactttctgc tttcccgaag ttcagataac     4119

tgggttggct ctcaattaga ccaggtagtt tgttgcattg caggtaagtc tggttttgtc     4179

ccttccagga ggacatagcc tgcaaagctg gttgtcttta catgaaagcg tttacatgag     4239

actttccgac tgcttttttg attctgaagt tcagcatcta aagcagcagg tctagaagaa     4299

caacggttta ttcatacttg cattcttttg gcagttctga taagcttcct agaaagttct     4359

gtgtaaacag aagcctgttt cagaaatctg gagctggcac tgtggagacc acacaccctt     4419

tgggaaagct cttgtctctt cttcccccac tacctcttat ttatttggtg tttgcttgaa     4479

tgctggtact attgtgacca caggctggtg tgtaggtggt aaaacctgtt ctccatagga     4539

gggaaggagc agtcactggg agaggttacc cgagaagcac ttgagcatga ggaactgcac     4599

ctttaggcca tctcagcttg ctgggccttt tgttaaaccc ttctgtctac tggcctccct     4659

ttgtgtgcat acgcctcttg ttcatgtcag cttatatgtg acactgcagc agaaaggctc     4719

tgaaggtcca aagagtttct gcaaagtgta tgtgaccatc atttcccagg ccattagggt     4779

tgcctcactg tagcaggttc taggctacca gaagaggggc agctttttca taccaattcc     4839

aactttcagg ggctgactct ccagggagct gatgtcatca cactctccat gttagtaatg     4899

gcagagcagt ctaaacagag tccgggagaa tgctggcaaa ggctggctgt gtatacccac     4959

taggctgccc cacgtgctcc cgagagatga cactagtcag aaaattggca gtggcagaga     5019

atccaaactc aacaagtgct cctgaaagaa acgctagaag cctaagaact gtggtctggt     5079

gttccagctg aggcaggggg atttggtagg aaggagccag tgaacttggc tttcctgttt     5139

ctatctttca ttaaaaagaa tagaaggatt cagtcataaa gaggtaaaaa actgtcacgg     5199

tacgaaatct tagtgcccac ggaggcctcg agcagagaga atgaaagtct tttttttttt     5259

tttttttttt tagcatggca ataaatattc tagcatccct aactaaaggg gactagacag     5319

ttagagactc tgtcacccta gctataccag cagaaaacct gttcaggcag gctttctggg     5379

tgtgactgat tcccagcctg tggcagggcg tggtcccaac tactcagcct agcacaggct     5439

ggcagttggt actgaattgt cagatgtgga gtattagtga caccacacat ttaattcagc     5499

tttgtccaaa ggaaagctta aaacccaata cagtctagtt tcctggttcc gttttagaaa     5559

aggaaaacgt gaacaaactt agaaagggaa ggaaatccca tcagtgaatc ctgaaactgg     5619

ttttaagtgc tttccttctc ctcatgccca agagatctgt gccatagaac aagataccag     5679

gcacttaaag ccttttcctg aattggaaag gaaaagaggc ccaagtgcaa aagaaaaaac     5739

attttagaaa cggacagctt ataaaaataa agggaagaaa ggaggcagca tggagagagg     5799

cctgtgctag aagctccatg gacgtgtctg cacagggtcc tcagctcatc catgcggcct     5859

gggtgtcctt ttactcagct ttataacaaa tgtggctcca agctcaggtg cctttgagtt     5919

ctaggaggct gtgggtttta ttcaactacg gttgggagaa tgagacctgg agtcatgttg     5979

aaggtgccca acctaaaaat gtaggctttc atgttgcaaa gaactccaga gtcagtagtt     6039

aggtttggtt tggttttgga catgataaac ctgccaagag tcaacaggtc acttgatcat     6099

gctgcagtgg gtagttctaa ggatggaaag gtgacagtat tactctcgag aggcaattca     6159

gtcctgggca aaggtattag tacaataagc gttaagggca gagtctacct tgaaaccaat     6219

taagcagctt ggtattcata aatattggga ttggatggcc tccatccaga aatcactatg     6279

ggtgagcata cctgtctcag ctgtttggcc aatgtgcata acctactcgg atccccacct     6339

gacactaacc agagtcagca caggccccga ggagcccgaa gtctgctgct gtgcagcatg     6399

gaattccttt aaaaaggtgc actacagttt tagcggggag ggggatagga agacgcagag     6459

caaatgagct ccggagtccc tgcaggtgaa taaacacaca gatctgcatc tgatagaact     6519

ttgatggatt ttcaaaaagc cgttgacaag gctctgctat acagtctata aaaattgtta     6579

ttatgggatt ggaagaaaca cgtggtcatg aatagaaaaa aaacaaaccc aaaggtagga     6639

aggtcaaggt catttcttag atggagaagt tgtgaaagat gtccttggag atgagtttta     6699

ggaccagcat tactaaggca ggtgggcaga cagtgacctc tctaggtgtg tccacagagt     6759

ttttcaggag agaaaactgc ctgacctttg ggactaagct gcggaatctt cttactaagc     6819

ttgaagagtg gagaggcgag aggtgagcta ctttgtgagc caaagcttat gtgacatggt     6879

tggggaaaca gtccaaactg ttctgagaag gtgaactgtt acgacccagg acaattagaa     6939

aaattcaccc accatgccgc acattactgg gtaaaagcag ggcagcaggg aacaaaactc     6999

cagactcttg ggccgtcccc atttgcaaca gcacacatag tttctggtat atttgttggg     7059

aaagataaaa ctctagcagt tgttgagggg aggatgtata aaatggtcat ggggatgaaa     7119

ggatctctga gaccacagag gctcagactc actgttaaga atagaaaact gggtatgcgt     7179

ttcatgtagc cagcagaact gaagtgtgct gtgacaagcc aatgtgaatt tctaccaaat     7239

agtagagcat accacttgaa gaaggaaaga accgaagagc aaacaaaagt tctgcgtaat     7299

gagactcacc ttttctcgct gaaagcacta agaggtggga ggaggcctgc acaggctgga     7359

ggagggtttg ggcagagcga agacccggcc aggaccttgg tgagatgggg tgccgcccac     7419

ctcctgcgga tactcttgga gagttgttcc cccagggggc tctgccccac ctggagaagg     7479

aagctgcctg gtgtggagtg actcaaatca gtatacctat ctgctgcacc ttcactctcc     7539

agggtacatg ctttaaaacc gacccgcaac aagtattgga aaaatgtatc cagtctgaag     7599

atgtttgtgt atctgtttac atccagagtt ctgtgacaca tgccccccag attgctgcaa     7659

agatcccaag gcattgattg cacttgatta agcttttgtc tgtaggtgaa agaacaagtt     7719

taggtcgagg actggcccct aggctgctgc tgtgaccctt gtcccatgtg gcttgtttgc     7779

ctgtccggga ctcttcgatg tgcccagggg agcgtgttcc tgtctcttcc atgccgtcct     7839

gcagtcctta tctgctcgcc tgagggaaga gtagctgtag ctacaaggga agcctgcctg     7899

gaagagccga gcacctgtgc ccatggcttc tggtcatgaa acgagttaat gatggcagag     7959

gagcttcctc cccacttcgc agcgccacat tatccatcct ctgagataag taggctggtt     8019

taaccattgg aatggacctt tcagtggaaa ccctgagagt ctgagaaccc ccagaccaac     8079

ccttccctcc ctttccccac ctcttacagt gtttggacag gagggtatgg tgctgctctg     8139

tgtagcaagt actttggctt atgaaagagg cagccacgca ttttgcacta ggaagaatca     8199

gtaatcactt ttcagaagac ttctatggac cacaaatata ttacggagga acagattttg     8259

ctaagacata atctagtttt ataactcaat catgaatgaa ccatgtgtgg caaacttgca     8319

gtttaaaggg gtcccatcag tgaaagaaac tgattttttt taacggactg cttttagtta     8379

aattgaagaa agtcagctct tgtcaaaagg tctaaacttt cccgcctcaa tcctaaaagc     8439

atgtcaacaa tccacatcag atgccataaa tatgaactgc aggataaaat ggtacaatct     8499

tagtgaatgg gaattggaat caaaagagtt tgctgtcctt cttagaatgt tctaaaatgt     8559

caaggcagtt gcttgtgttt aactgtgaac aaataaaaat ttattgtttt gcactaaa       8617


<210>  778
<211>  1164
<212>  PRT
<213>  Homo sapiens

<400>  778

Met Ala Gln Gln Ala Asn Val Gly Glu Leu Leu Ala Met Leu Asp Ser 
1               5                   10                  15      


Pro Met Leu Gly Val Arg Asp Asp Val Thr Ala Val Phe Lys Glu Asn 
            20                  25                  30          


Leu Asn Ser Asp Arg Gly Pro Met Leu Val Asn Thr Leu Val Asp Tyr 
        35                  40                  45              


Tyr Leu Glu Thr Ser Ser Gln Pro Ala Leu His Ile Leu Thr Thr Leu 
    50                  55                  60                  


Gln Glu Pro His Asp Lys His Leu Leu Asp Arg Ile Asn Glu Tyr Val 
65                  70                  75                  80  


Gly Lys Ala Ala Thr Arg Leu Ser Ile Leu Ser Leu Leu Gly His Val 
                85                  90                  95      


Ile Arg Leu Gln Pro Ser Trp Lys His Lys Leu Ser Gln Ala Pro Leu 
            100                 105                 110         


Leu Pro Ser Leu Leu Lys Cys Leu Lys Met Asp Thr Asp Val Val Val 
        115                 120                 125             


Leu Thr Thr Gly Val Leu Val Leu Ile Thr Met Leu Pro Met Ile Pro 
    130                 135                 140                 


Gln Ser Gly Lys Gln His Leu Leu Asp Phe Phe Asp Ile Phe Gly Arg 
145                 150                 155                 160 


Leu Ser Ser Trp Cys Leu Lys Lys Pro Gly His Val Ala Glu Val Tyr 
                165                 170                 175     


Leu Val His Leu His Ala Ser Val Tyr Ala Leu Phe His Arg Leu Tyr 
            180                 185                 190         


Gly Met Tyr Pro Cys Asn Phe Val Ser Phe Leu Arg Ser His Tyr Ser 
        195                 200                 205             


Met Lys Glu Asn Leu Glu Thr Phe Glu Glu Val Val Lys Pro Met Met 
    210                 215                 220                 


Glu His Val Arg Ile His Pro Glu Leu Val Thr Gly Ser Lys Asp His 
225                 230                 235                 240 


Glu Leu Asp Pro Arg Arg Trp Lys Arg Leu Glu Thr His Asp Val Val 
                245                 250                 255     


Ile Glu Cys Ala Lys Ile Ser Leu Asp Pro Thr Glu Ala Ser Tyr Glu 
            260                 265                 270         


Asp Gly Tyr Ser Val Ser His Gln Ile Ser Ala Arg Phe Pro His Arg 
        275                 280                 285             


Ser Ala Asp Val Thr Thr Ser Pro Tyr Ala Asp Thr Gln Asn Ser Tyr 
    290                 295                 300                 


Gly Cys Ala Thr Ser Thr Pro Tyr Ser Thr Ser Arg Leu Met Leu Leu 
305                 310                 315                 320 


Asn Met Pro Gly Gln Leu Pro Gln Thr Leu Ser Ser Pro Ser Thr Arg 
                325                 330                 335     


Leu Ile Thr Glu Pro Pro Gln Ala Thr Leu Trp Ser Pro Ser Met Val 
            340                 345                 350         


Cys Gly Met Thr Thr Pro Pro Thr Ser Pro Gly Asn Val Pro Pro Asp 
        355                 360                 365             


Leu Ser His Pro Tyr Ser Lys Val Phe Gly Thr Thr Ala Gly Gly Lys 
    370                 375                 380                 


Gly Thr Pro Leu Gly Thr Pro Ala Thr Ser Pro Pro Pro Ala Pro Leu 
385                 390                 395                 400 


Cys His Ser Asp Asp Tyr Val His Ile Ser Leu Pro Gln Ala Thr Val 
                405                 410                 415     


Thr Pro Pro Arg Lys Glu Glu Arg Met Asp Ser Ala Arg Pro Cys Leu 
            420                 425                 430         


His Arg Gln His His Leu Leu Asn Asp Arg Gly Ser Glu Glu Pro Pro 
        435                 440                 445             


Gly Ser Lys Gly Ser Val Thr Leu Ser Asp Leu Pro Gly Phe Leu Gly 
    450                 455                 460                 


Asp Leu Ala Ser Glu Glu Asp Ser Ile Glu Lys Asp Lys Glu Glu Ala 
465                 470                 475                 480 


Ala Ile Ser Arg Glu Leu Ser Glu Ile Thr Thr Ala Glu Ala Glu Pro 
                485                 490                 495     


Val Val Pro Arg Gly Gly Phe Asp Ser Pro Phe Tyr Arg Asp Ser Leu 
            500                 505                 510         


Pro Gly Ser Gln Arg Lys Thr His Ser Ala Ala Ser Ser Ser Gln Gly 
        515                 520                 525             


Ala Ser Val Asn Pro Glu Pro Leu His Ser Ser Leu Asp Lys Leu Gly 
    530                 535                 540                 


Pro Asp Thr Pro Lys Gln Ala Phe Thr Pro Ile Asp Leu Pro Cys Gly 
545                 550                 555                 560 


Ser Ala Asp Glu Ser Pro Ala Gly Asp Arg Glu Cys Gln Thr Ser Leu 
                565                 570                 575     


Glu Thr Ser Ile Phe Thr Pro Ser Pro Cys Lys Ile Pro Pro Pro Thr 
            580                 585                 590         


Arg Val Gly Phe Gly Ser Gly Gln Pro Pro Pro Tyr Asp His Leu Phe 
        595                 600                 605             


Glu Val Ala Leu Pro Lys Thr Ala His His Phe Val Ile Arg Lys Thr 
    610                 615                 620                 


Glu Glu Leu Leu Lys Lys Ala Lys Gly Asn Thr Glu Glu Asp Gly Val 
625                 630                 635                 640 


Pro Ser Thr Ser Pro Met Glu Val Leu Asp Arg Leu Ile Gln Gln Gly 
                645                 650                 655     


Ala Asp Ala His Ser Lys Glu Leu Asn Lys Leu Pro Leu Pro Ser Lys 
            660                 665                 670         


Ser Val Asp Trp Thr His Phe Gly Gly Ser Pro Pro Ser Asp Glu Ile 
        675                 680                 685             


Arg Thr Leu Arg Asp Gln Leu Leu Leu Leu His Asn Gln Leu Leu Tyr 
    690                 695                 700                 


Glu Arg Phe Lys Arg Gln Gln His Ala Leu Arg Asn Arg Arg Leu Leu 
705                 710                 715                 720 


Arg Lys Val Ile Lys Ala Ala Ala Leu Glu Glu His Asn Ala Ala Met 
                725                 730                 735     


Lys Asp Gln Leu Lys Leu Gln Glu Lys Asp Ile Gln Met Trp Lys Val 
            740                 745                 750         


Ser Leu Gln Lys Glu Gln Ala Arg Tyr Asn Gln Leu Gln Glu Gln Arg 
        755                 760                 765             


Asp Thr Met Val Thr Lys Leu His Ser Gln Ile Arg Gln Leu Gln His 
    770                 775                 780                 


Asp Arg Glu Glu Phe Tyr Asn Gln Ser Gln Glu Leu Gln Thr Lys Leu 
785                 790                 795                 800 


Glu Asp Cys Arg Asn Met Ile Ala Glu Leu Arg Ile Glu Leu Lys Lys 
                805                 810                 815     


Ala Asn Asn Lys Val Cys His Thr Glu Leu Leu Leu Ser Gln Val Ser 
            820                 825                 830         


Gln Lys Leu Ser Asn Ser Glu Ser Val Gln Gln Gln Met Glu Phe Leu 
        835                 840                 845             


Asn Arg Gln Leu Leu Val Leu Gly Glu Val Asn Glu Leu Tyr Leu Glu 
    850                 855                 860                 


Gln Leu Gln Asn Lys His Ser Asp Thr Thr Lys Glu Val Glu Met Met 
865                 870                 875                 880 


Lys Ala Ala Tyr Arg Lys Glu Leu Glu Lys Asn Arg Ser His Val Leu 
                885                 890                 895     


Gln Gln Thr Gln Arg Leu Asp Thr Ser Gln Lys Arg Ile Leu Glu Leu 
            900                 905                 910         


Glu Ser His Leu Ala Lys Lys Asp His Leu Leu Leu Glu Gln Lys Lys 
        915                 920                 925             


Tyr Leu Glu Asp Val Lys Leu Gln Ala Arg Gly Gln Leu Gln Ala Ala 
    930                 935                 940                 


Glu Ser Arg Tyr Glu Ala Gln Lys Arg Ile Thr Gln Val Phe Glu Leu 
945                 950                 955                 960 


Glu Ile Leu Asp Leu Tyr Gly Arg Leu Glu Lys Asp Gly Leu Leu Lys 
                965                 970                 975     


Lys Leu Glu Glu Glu Lys Ala Glu Ala Ala Glu Ala Ala Glu Glu Arg 
            980                 985                 990         


Leu Asp Cys Cys Asn Asp Gly Cys  Ser Asp Ser Met Val  Gly His Asn 
        995                 1000                 1005             


Glu Glu  Ala Ser Gly His Asn  Gly Glu Thr Lys Thr  Pro Arg Pro 
    1010                 1015                 1020             


Ser Ser  Ala Arg Gly Ser Ser  Gly Ser Arg Gly Gly  Gly Gly Ser 
    1025                 1030                 1035             


Ser Ser  Ser Ser Ser Glu Leu  Ser Thr Pro Glu Lys  Pro Pro His 
    1040                 1045                 1050             


Gln Arg  Ala Gly Pro Phe Ser  Ser Arg Trp Glu Thr  Thr Met Gly 
    1055                 1060                 1065             


Glu Ala  Ser Ala Ser Ile Pro  Thr Thr Val Gly Ser  Leu Pro Ser 
    1070                 1075                 1080             


Ser Lys  Ser Phe Leu Gly Met  Lys Ala Arg Glu Leu  Phe Arg Asn 
    1085                 1090                 1095             


Lys Ser  Glu Ser Gln Cys Asp  Glu Asp Gly Met Thr  Ser Ser Leu 
    1100                 1105                 1110             


Ser Glu  Ser Leu Lys Thr Glu  Leu Gly Lys Asp Leu  Gly Val Glu 
    1115                 1120                 1125             


Ala Lys  Ile Pro Leu Asn Leu  Asp Gly Pro His Pro  Ser Pro Pro 
    1130                 1135                 1140             


Thr Pro  Asp Ser Val Gly Gln  Leu His Ile Met Asp  Tyr Asn Glu 
    1145                 1150                 1155             


Thr His  His Glu His Ser 
    1160                 


<210>  779
<211>  1998
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (83)..(1177)

<400>  779
cccactggcc ggtataaagc accgtgaccc tcaggtgacg caccagggcc ggctgccgtc       60

ggggacaggg ctttccatag cc atg gcc cag cag tgg agc ctc caa agg ctc       112
                         Met Ala Gln Gln Trp Ser Leu Gln Arg Leu          
                         1               5                   10           

gca ggc cgc cat ccg cag gac agc tat gag gac agc acc cag tcc agc        160
Ala Gly Arg His Pro Gln Asp Ser Tyr Glu Asp Ser Thr Gln Ser Ser           
                15                  20                  25                

atc ttc acc tac acc aac agc aac tcc acc aga ggc ccc ttc gaa ggc        208
Ile Phe Thr Tyr Thr Asn Ser Asn Ser Thr Arg Gly Pro Phe Glu Gly           
            30                  35                  40                    

ccg aat tac cac atc gct ccc aga tgg gtg tac cac ctc acc agt gtc        256
Pro Asn Tyr His Ile Ala Pro Arg Trp Val Tyr His Leu Thr Ser Val           
        45                  50                  55                        

tgg atg atc ttt gtg gtc att gca tcc gtc ttc aca aat ggg ctt gtg        304
Trp Met Ile Phe Val Val Ile Ala Ser Val Phe Thr Asn Gly Leu Val           
    60                  65                  70                            

ctg gcg gcc acc atg aag ttc aag aag ctg cgc cac ccg ctg aac tgg        352
Leu Ala Ala Thr Met Lys Phe Lys Lys Leu Arg His Pro Leu Asn Trp           
75                  80                  85                  90            

atc ctg gtg aac ctg gcg gtc gct gac ctg gca gag acc gtc atc gcc        400
Ile Leu Val Asn Leu Ala Val Ala Asp Leu Ala Glu Thr Val Ile Ala           
                95                  100                 105               

agc act atc agc gtt gtg aac cag gtc tat ggc tac ttc gtg ctg ggc        448
Ser Thr Ile Ser Val Val Asn Gln Val Tyr Gly Tyr Phe Val Leu Gly           
            110                 115                 120                   

cac cct atg tgt gtc ctg gag ggc tac acc gtc tcc ctg tgt ggg atc        496
His Pro Met Cys Val Leu Glu Gly Tyr Thr Val Ser Leu Cys Gly Ile           
        125                 130                 135                       

aca ggt ctc tgg tct ctg gcc atc att tcc tgg gag aga tgg atg gtg        544
Thr Gly Leu Trp Ser Leu Ala Ile Ile Ser Trp Glu Arg Trp Met Val           
    140                 145                 150                           

gtc tgc aag ccc ttt ggc aat gtg aga ttt gat gcc aag ctg gcc atc        592
Val Cys Lys Pro Phe Gly Asn Val Arg Phe Asp Ala Lys Leu Ala Ile           
155                 160                 165                 170           

gtg ggc att gcc ttc tcc tgg atc tgg gct gct gtg tgg aca gcc ccg        640
Val Gly Ile Ala Phe Ser Trp Ile Trp Ala Ala Val Trp Thr Ala Pro           
                175                 180                 185               

ccc atc ttt ggt tgg agc agg tac tgg ccc cac ggc ctg aag act tca        688
Pro Ile Phe Gly Trp Ser Arg Tyr Trp Pro His Gly Leu Lys Thr Ser           
            190                 195                 200                   

tgc ggc cca gac gtg ttc agc ggc agc tcg tac ccc ggg gtg cag tct        736
Cys Gly Pro Asp Val Phe Ser Gly Ser Ser Tyr Pro Gly Val Gln Ser           
        205                 210                 215                       

tac atg att gtc ctc atg gtc acc tgc tgc atc acc cca ctc agc atc        784
Tyr Met Ile Val Leu Met Val Thr Cys Cys Ile Thr Pro Leu Ser Ile           
    220                 225                 230                           

atc gtg ctc tgc tac ctc caa gtg tgg ctg gcc atc cga gcg gtg gca        832
Ile Val Leu Cys Tyr Leu Gln Val Trp Leu Ala Ile Arg Ala Val Ala           
235                 240                 245                 250           

aag cag cag aaa gag tct gaa tcc acc cag aag gca gag aag gaa gtg        880
Lys Gln Gln Lys Glu Ser Glu Ser Thr Gln Lys Ala Glu Lys Glu Val           
                255                 260                 265               

acg cgc atg gtg gtg gtg atg gtc ctg gca ttc tgc ttc tgc tgg gga        928
Thr Arg Met Val Val Val Met Val Leu Ala Phe Cys Phe Cys Trp Gly           
            270                 275                 280                   

cca tac gcc ttc ttc gca tgc ttt gct gct gcc aac cct ggc tac ccc        976
Pro Tyr Ala Phe Phe Ala Cys Phe Ala Ala Ala Asn Pro Gly Tyr Pro           
        285                 290                 295                       

ttc cac cct ttg atg gct gcc ctg ccg gcc ttc ttt gcc aaa agt gcc       1024
Phe His Pro Leu Met Ala Ala Leu Pro Ala Phe Phe Ala Lys Ser Ala           
    300                 305                 310                           

act atc tac aac ccc gtt atc tat gtc ttt atg aac cgg cag ttt cga       1072
Thr Ile Tyr Asn Pro Val Ile Tyr Val Phe Met Asn Arg Gln Phe Arg           
315                 320                 325                 330           

aac tgc atc ttg cag ctt ttc ggg aag aag gtt gac gat ggc tct gaa       1120
Asn Cys Ile Leu Gln Leu Phe Gly Lys Lys Val Asp Asp Gly Ser Glu           
                335                 340                 345               

ctc tcc agc gcc tcc aaa acg gag gtc tca tct gtg tcc tcg gta tcg       1168
Leu Ser Ser Ala Ser Lys Thr Glu Val Ser Ser Val Ser Ser Val Ser           
            350                 355                 360                   

cct gca tga ggtctgcctc ctacccatcc cgcccaccgg ggctttggcc               1217
Pro Ala                                                                   
                                                                          

acctctcctt tccccctcct tctccatccc tgtaaaataa atgtaattta tctttgccaa     1277

aaccaacaaa gtcacagagg ctttcactgc agtgtgggac cacctgagcc tctgcgtgtg     1337

caggcactgg gtctcgagag ggtgcaaggg ggataaagag gagagagcgc ttcatagact     1397

ttaagttttc ccgagcctca tgtctaccga tggcgtgaaa ggatcctggc aaaacagaag     1457

tgtgaggcag gtgggcgtct atatccattt caccaggctg gtggttacat aatcggcaag     1517

caagagctgt ggaggggctt gctggatgcc ctcagcaccc aggaggaggg agggagctag     1577

caagctaagg caggtggccc tcctggcccc ttaaggtcca tctgctggag gcccagagtc     1637

cttggagtac agtctacacc tggaggggac ccattcctgc cagtctgtgg cagggatggc     1697

gcgccacctc tgccaggcca ggaccccaag cccgatcagc atcagcatgg tgcaggtgca     1757

caggcgtgag ctgatcagtg acgaggggca ggcacacaag gtggagacaa agaccaagag     1817

gacggttgcc agtgagaggc gcggactcag gaacttgaac aacatctgcg ggggacggct     1877

ttggaggtgc tccgctgcct ccagttgggt gacttgctgt agcatctcca gcttggatat     1937

tcggctcttg aaggtctccg tgatctcctg caggagacga aaatgcacgc accagaagtc     1997

a                                                                     1998


<210>  780
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  780

Met Ala Gln Gln Trp Ser Leu Gln Arg Leu Ala Gly Arg His Pro Gln 
1               5                   10                  15      


Asp Ser Tyr Glu Asp Ser Thr Gln Ser Ser Ile Phe Thr Tyr Thr Asn 
            20                  25                  30          


Ser Asn Ser Thr Arg Gly Pro Phe Glu Gly Pro Asn Tyr His Ile Ala 
        35                  40                  45              


Pro Arg Trp Val Tyr His Leu Thr Ser Val Trp Met Ile Phe Val Val 
    50                  55                  60                  


Ile Ala Ser Val Phe Thr Asn Gly Leu Val Leu Ala Ala Thr Met Lys 
65                  70                  75                  80  


Phe Lys Lys Leu Arg His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala 
                85                  90                  95      


Val Ala Asp Leu Ala Glu Thr Val Ile Ala Ser Thr Ile Ser Val Val 
            100                 105                 110         


Asn Gln Val Tyr Gly Tyr Phe Val Leu Gly His Pro Met Cys Val Leu 
        115                 120                 125             


Glu Gly Tyr Thr Val Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu 
    130                 135                 140                 


Ala Ile Ile Ser Trp Glu Arg Trp Met Val Val Cys Lys Pro Phe Gly 
145                 150                 155                 160 


Asn Val Arg Phe Asp Ala Lys Leu Ala Ile Val Gly Ile Ala Phe Ser 
                165                 170                 175     


Trp Ile Trp Ala Ala Val Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser 
            180                 185                 190         


Arg Tyr Trp Pro His Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe 
        195                 200                 205             


Ser Gly Ser Ser Tyr Pro Gly Val Gln Ser Tyr Met Ile Val Leu Met 
    210                 215                 220                 


Val Thr Cys Cys Ile Thr Pro Leu Ser Ile Ile Val Leu Cys Tyr Leu 
225                 230                 235                 240 


Gln Val Trp Leu Ala Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser 
                245                 250                 255     


Glu Ser Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Val Val 
            260                 265                 270         


Met Val Leu Ala Phe Cys Phe Cys Trp Gly Pro Tyr Ala Phe Phe Ala 
        275                 280                 285             


Cys Phe Ala Ala Ala Asn Pro Gly Tyr Pro Phe His Pro Leu Met Ala 
    290                 295                 300                 


Ala Leu Pro Ala Phe Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Val 
305                 310                 315                 320 


Ile Tyr Val Phe Met Asn Arg Gln Phe Arg Asn Cys Ile Leu Gln Leu 
                325                 330                 335     


Phe Gly Lys Lys Val Asp Asp Gly Ser Glu Leu Ser Ser Ala Ser Lys 
            340                 345                 350         


Thr Glu Val Ser Ser Val Ser Ser Val Ser Pro Ala 
        355                 360                 


<210>  781
<211>  2546
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (799)..(2019)

<400>  781
cagcggcggc ccaggaggca gccggtgagc gcctgcgagc agagtggcgg gggccgctga       60

caggtcccgc gcagcccagc ccagcccagc cacgcggctc acaggtgggg tccaagagca      120

gtttggagca acccggcgct acggagaggg gtggacggct ctgcacgggc ctcctgtctc      180

ccgctcgggc agagggactc ggggggacct cgctccttgg ccgagagaac ctgaactcgg      240

gcggagagaa cgcgcccagg cgggcaaggg gaccagagaa agccggggct ggaagtcact      300

gtcgctcgcc actgtctgga gcgcacggag cgcagaggcc cggcagccgc gcgtgccctc      360

ccggggaccg agccagtgat gcaggatcgc tgagcggaga tccgcgccga gaagtctctc      420

ggggccgggg ctgagacgca cgccttcgac accgctgcca agaccccgat tccggcgact      480

cttgcgggga accgaggggc caaggctgcc ccaagctcag gacttgggcg agtctaagac      540

gatggtttct taagcacgga cccgcgttcc ccttcccgcc ccctcgactg gaggcaggga      600

tcctgcgcgg ggcccccggg attccgtttc cccgcggagc cccggccgct gcctcccggg      660

acagttcgca cggccacagg ggcgcacggc gatgtggcct ccgtccagcg cgctggcccg      720

ccggggggat gctctggcac ctgtcggggt ccaggcctag catggccggc gcgttgcccg      780

acgtcgcctc cggctagg atg gcc cct ccg ggc ccg gcc agt gcc ctc tcc        831
                    Met Ala Pro Pro Gly Pro Ala Ser Ala Leu Ser           
                    1               5                   10                

acc tcg gcc gag ccg ctg tcc cgc agc atc ttc cgg aag ttc ttg ctg        879
Thr Ser Ala Glu Pro Leu Ser Arg Ser Ile Phe Arg Lys Phe Leu Leu           
            15                  20                  25                    

atg ctc tgc tcc ctg ctc acg tcc ctt tac gtc ttc tac tgc ctg gcc        927
Met Leu Cys Ser Leu Leu Thr Ser Leu Tyr Val Phe Tyr Cys Leu Ala           
        30                  35                  40                        

gag cgc tgc cag acc ctg tcc ggc ccc gtc gtg ggg ctg tcc ggc ggc        975
Glu Arg Cys Gln Thr Leu Ser Gly Pro Val Val Gly Leu Ser Gly Gly           
    45                  50                  55                            

ggc gag gag gcg ggg gcc cct ggt ggc ggc gtc ctg gcc gga ggc ccg       1023
Gly Glu Glu Ala Gly Ala Pro Gly Gly Gly Val Leu Ala Gly Gly Pro           
60                  65                  70                  75            

agg gag ctg gcg gtg tgg ccg gcg gcg gca cag aga aag cgc ctc ctg       1071
Arg Glu Leu Ala Val Trp Pro Ala Ala Ala Gln Arg Lys Arg Leu Leu           
                80                  85                  90                

caa ctg ccg cag tgg cgg agg cgc cgg ccg ccc gcg ccc cgc gac gac       1119
Gln Leu Pro Gln Trp Arg Arg Arg Arg Pro Pro Ala Pro Arg Asp Asp           
            95                  100                 105                   

ggc gag gag gcg gcc tgg gaa gaa gag tcc cct ggc ctg tca ggg ggt       1167
Gly Glu Glu Ala Ala Trp Glu Glu Glu Ser Pro Gly Leu Ser Gly Gly           
        110                 115                 120                       

ccg ggc ggc tcc ggg gcc gga agc acc gtg gcc gag gcc ccg ccg ggg       1215
Pro Gly Gly Ser Gly Ala Gly Ser Thr Val Ala Glu Ala Pro Pro Gly           
    125                 130                 135                           

acc ctg gcg ctg ctc ctg gac gaa ggc agc aag cag ctg ccg cag gcc       1263
Thr Leu Ala Leu Leu Leu Asp Glu Gly Ser Lys Gln Leu Pro Gln Ala           
140                 145                 150                 155           

atc atc atc gga gtg aag aag ggc ggc acg cgg gcg ctg ctg gag ttc       1311
Ile Ile Ile Gly Val Lys Lys Gly Gly Thr Arg Ala Leu Leu Glu Phe           
                160                 165                 170               

ctg cgc gtg cac ccc gac gtg cgc gcc gtg ggc gcc gag ccc cac ttc       1359
Leu Arg Val His Pro Asp Val Arg Ala Val Gly Ala Glu Pro His Phe           
            175                 180                 185                   

ttc gac cgc agc tac gac aag ggc ctc gcc tgg tac cgg gac ctg atg       1407
Phe Asp Arg Ser Tyr Asp Lys Gly Leu Ala Trp Tyr Arg Asp Leu Met           
        190                 195                 200                       

ccc aga acc ctg gac ggg cag atc acc atg gag aag acg ccc agt tac       1455
Pro Arg Thr Leu Asp Gly Gln Ile Thr Met Glu Lys Thr Pro Ser Tyr           
    205                 210                 215                           

ttc gtc acg cgg gag gcc ccc gcg cgc atc tcg gcc atg tcc aag gac       1503
Phe Val Thr Arg Glu Ala Pro Ala Arg Ile Ser Ala Met Ser Lys Asp           
220                 225                 230                 235           

acc aag ctc atc gtg gtg gtg cgg gac ccg gtg acc agg gcc atc tcg       1551
Thr Lys Leu Ile Val Val Val Arg Asp Pro Val Thr Arg Ala Ile Ser           
                240                 245                 250               

gac tac acg cag acg ctg tcc aag cgg ccc gac atc ccc acc ttc gag       1599
Asp Tyr Thr Gln Thr Leu Ser Lys Arg Pro Asp Ile Pro Thr Phe Glu           
            255                 260                 265                   

agc ttg acg ttc aaa aac agg aca gcg ggc ctc atc gac acg tcg tgg       1647
Ser Leu Thr Phe Lys Asn Arg Thr Ala Gly Leu Ile Asp Thr Ser Trp           
        270                 275                 280                       

agc gcc atc cag atc ggc atc tac gcc aag cac ctg gag cac tgg ctg       1695
Ser Ala Ile Gln Ile Gly Ile Tyr Ala Lys His Leu Glu His Trp Leu           
    285                 290                 295                           

cgc cac ttc ccc atc cgc cag atg ctc ttc gtg agc ggc gag cgg ctc       1743
Arg His Phe Pro Ile Arg Gln Met Leu Phe Val Ser Gly Glu Arg Leu           
300                 305                 310                 315           

atc agc gac ccg gcc ggg gag ctg ggc cgc gtg caa gac ttc ctg ggc       1791
Ile Ser Asp Pro Ala Gly Glu Leu Gly Arg Val Gln Asp Phe Leu Gly           
                320                 325                 330               

ctc aag agg atc atc acg gac aag cac ttc tac ttc aac aag acc aag       1839
Leu Lys Arg Ile Ile Thr Asp Lys His Phe Tyr Phe Asn Lys Thr Lys           
            335                 340                 345                   

ggc ttc ccc tgc ctg aag aag gcg gag ggc agc agc cgg ccc cat tgc       1887
Gly Phe Pro Cys Leu Lys Lys Ala Glu Gly Ser Ser Arg Pro His Cys           
        350                 355                 360                       

ctg ggc aag acc aag ggc agg acc cat cct gag atc gac cgc gag gtg       1935
Leu Gly Lys Thr Lys Gly Arg Thr His Pro Glu Ile Asp Arg Glu Val           
    365                 370                 375                           

gtg cgc agg ctg cgc gag ttc tac cgg cct ttc aac ctc aag ttc tac       1983
Val Arg Arg Leu Arg Glu Phe Tyr Arg Pro Phe Asn Leu Lys Phe Tyr           
380                 385                 390                 395           

cag atg acc ggg cac gac ttt ggc tgg gat gga taa ccatataatt            2029
Gln Met Thr Gly His Asp Phe Gly Trp Asp Gly                               
                400                 405                                   

taaaaagaaa aaaaaaatca aaatataata tattttttta ccaatcggta gagaagagac     2089

agtttaatat ttgtgctgaa aatatgtttc agtatttttt tcaatgaatg ttaagagatt     2149

gttctcactc ccgccccatc ttaatgtata accaacacca aacacgtgga tcaacagaaa     2209

aggaaaattt cactcgtcta aacactttca attttcagtt tttattttat gttctatata     2269

cccagtcata aagtataagc atcagttgtc attaaaagtt ttcagaaaat cttgaggtta     2329

aacatctctc tctctttttt taaaatacaa ggccctgata aaattgatat ctatccttat     2389

atttttctcc ctttttcccg tgccactttt tcttaaatta tttcccagtt agtattatca     2449

tatgtttgta cccgtcacag ttttcatagt gctttcaaat acaccttttt gatcattaaa     2509

ataaaaaaat aaatcttgga aaaaaaaaaa aaaaaaa                              2546


<210>  782
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  782

Met Ala Pro Pro Gly Pro Ala Ser Ala Leu Ser Thr Ser Ala Glu Pro 
1               5                   10                  15      


Leu Ser Arg Ser Ile Phe Arg Lys Phe Leu Leu Met Leu Cys Ser Leu 
            20                  25                  30          


Leu Thr Ser Leu Tyr Val Phe Tyr Cys Leu Ala Glu Arg Cys Gln Thr 
        35                  40                  45              


Leu Ser Gly Pro Val Val Gly Leu Ser Gly Gly Gly Glu Glu Ala Gly 
    50                  55                  60                  


Ala Pro Gly Gly Gly Val Leu Ala Gly Gly Pro Arg Glu Leu Ala Val 
65                  70                  75                  80  


Trp Pro Ala Ala Ala Gln Arg Lys Arg Leu Leu Gln Leu Pro Gln Trp 
                85                  90                  95      


Arg Arg Arg Arg Pro Pro Ala Pro Arg Asp Asp Gly Glu Glu Ala Ala 
            100                 105                 110         


Trp Glu Glu Glu Ser Pro Gly Leu Ser Gly Gly Pro Gly Gly Ser Gly 
        115                 120                 125             


Ala Gly Ser Thr Val Ala Glu Ala Pro Pro Gly Thr Leu Ala Leu Leu 
    130                 135                 140                 


Leu Asp Glu Gly Ser Lys Gln Leu Pro Gln Ala Ile Ile Ile Gly Val 
145                 150                 155                 160 


Lys Lys Gly Gly Thr Arg Ala Leu Leu Glu Phe Leu Arg Val His Pro 
                165                 170                 175     


Asp Val Arg Ala Val Gly Ala Glu Pro His Phe Phe Asp Arg Ser Tyr 
            180                 185                 190         


Asp Lys Gly Leu Ala Trp Tyr Arg Asp Leu Met Pro Arg Thr Leu Asp 
        195                 200                 205             


Gly Gln Ile Thr Met Glu Lys Thr Pro Ser Tyr Phe Val Thr Arg Glu 
    210                 215                 220                 


Ala Pro Ala Arg Ile Ser Ala Met Ser Lys Asp Thr Lys Leu Ile Val 
225                 230                 235                 240 


Val Val Arg Asp Pro Val Thr Arg Ala Ile Ser Asp Tyr Thr Gln Thr 
                245                 250                 255     


Leu Ser Lys Arg Pro Asp Ile Pro Thr Phe Glu Ser Leu Thr Phe Lys 
            260                 265                 270         


Asn Arg Thr Ala Gly Leu Ile Asp Thr Ser Trp Ser Ala Ile Gln Ile 
        275                 280                 285             


Gly Ile Tyr Ala Lys His Leu Glu His Trp Leu Arg His Phe Pro Ile 
    290                 295                 300                 


Arg Gln Met Leu Phe Val Ser Gly Glu Arg Leu Ile Ser Asp Pro Ala 
305                 310                 315                 320 


Gly Glu Leu Gly Arg Val Gln Asp Phe Leu Gly Leu Lys Arg Ile Ile 
                325                 330                 335     


Thr Asp Lys His Phe Tyr Phe Asn Lys Thr Lys Gly Phe Pro Cys Leu 
            340                 345                 350         


Lys Lys Ala Glu Gly Ser Ser Arg Pro His Cys Leu Gly Lys Thr Lys 
        355                 360                 365             


Gly Arg Thr His Pro Glu Ile Asp Arg Glu Val Val Arg Arg Leu Arg 
    370                 375                 380                 


Glu Phe Tyr Arg Pro Phe Asn Leu Lys Phe Tyr Gln Met Thr Gly His 
385                 390                 395                 400 


Asp Phe Gly Trp Asp Gly 
                405     


<210>  783
<211>  7445
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (411)..(4997)

<400>  783
gggcctggtt gtggaggccc cttttgcaaa acctcagtct gaatttagta gacagaagtc       60

actaggaatg ccttgacagg atcctgcctt agctaaggct ccctccagct gcagagggtg      120

tttttgttag actcacacac tgcgtgaaac tgctcagaat agagccatga tctcaaccac      180

gaaatgggaa cttagatttt ggagaaacta acggggacgg acttctttcc tagcctgagt      240

gttgagcagt gtcatgcctt ggcgtttcag ctcctcgttg tctaggtggt gaaatgacag      300

aactcattcg cttctttgat tggtgatttt gaaataatct ttcatcaagt tccatctcct      360

ttaccctcat atggaatata tctctctgtc tgttgttaaa ctacgatgac atg tct         416
                                                       Met Ser            
                                                       1                  

gta gct atc aga aag aga agc tgg gaa gaa cat gtg acc cac tgg atg        464
Val Ala Ile Arg Lys Arg Ser Trp Glu Glu His Val Thr His Trp Met           
        5                   10                  15                        

gga cag cct ttt aat tct gat gat cgt aac aca gca tgt cat cat gga        512
Gly Gln Pro Phe Asn Ser Asp Asp Arg Asn Thr Ala Cys His His Gly           
    20                  25                  30                            

cta gta gct gac agc ttg cag gca agt atg gaa aaa gat gca act cta        560
Leu Val Ala Asp Ser Leu Gln Ala Ser Met Glu Lys Asp Ala Thr Leu           
35                  40                  45                  50            

aat gtg gac cgc aaa gag aag tgt gtt tca cta cct gac tgc tgt cat        608
Asn Val Asp Arg Lys Glu Lys Cys Val Ser Leu Pro Asp Cys Cys His           
                55                  60                  65                

gga tca gag ctg aga gat ttt cct ggg agg cca atg ggt cat ctt tca        656
Gly Ser Glu Leu Arg Asp Phe Pro Gly Arg Pro Met Gly His Leu Ser           
            70                  75                  80                    

aag gat gtg gac gaa aat gac agc cat gaa ggt gaa gat cag ttt ctt        704
Lys Asp Val Asp Glu Asn Asp Ser His Glu Gly Glu Asp Gln Phe Leu           
        85                  90                  95                        

tct ctg gaa gcc agc aca gaa aca cta gtg cat gtt tct gat gag gat        752
Ser Leu Glu Ala Ser Thr Glu Thr Leu Val His Val Ser Asp Glu Asp           
    100                 105                 110                           

aac aat gct gat tta tgc ctt aca gat gat aaa cag gtt tta aat acc        800
Asn Asn Ala Asp Leu Cys Leu Thr Asp Asp Lys Gln Val Leu Asn Thr           
115                 120                 125                 130           

caa ggg cag aaa aca tca ggc caa cat atg atc caa gga gca ggc tcc        848
Gln Gly Gln Lys Thr Ser Gly Gln His Met Ile Gln Gly Ala Gly Ser           
                135                 140                 145               

tta gaa aag gca ctg ccc atc ata caa agt aac caa gtt tct tct aac        896
Leu Glu Lys Ala Leu Pro Ile Ile Gln Ser Asn Gln Val Ser Ser Asn           
            150                 155                 160                   

tcc tgg gga ata gct ggt gaa act gaa tta gca ctg gta aaa gaa agt        944
Ser Trp Gly Ile Ala Gly Glu Thr Glu Leu Ala Leu Val Lys Glu Ser           
        165                 170                 175                       

ggg gag aga aaa gtt act gac tct ata agt aaa agc ctg gag ctt tgc        992
Gly Glu Arg Lys Val Thr Asp Ser Ile Ser Lys Ser Leu Glu Leu Cys           
    180                 185                 190                           

aat gaa ata agc tta agt gaa ata aaa gat gca ccc aaa gta aat gca       1040
Asn Glu Ile Ser Leu Ser Glu Ile Lys Asp Ala Pro Lys Val Asn Ala           
195                 200                 205                 210           

gtg gat act ttg aac gtg aaa gat att gca cct gag aaa caa ttg ctt       1088
Val Asp Thr Leu Asn Val Lys Asp Ile Ala Pro Glu Lys Gln Leu Leu           
                215                 220                 225               

aac tct gct gta att gct cag caa cga agg aaa cct gac ccc cct aaa       1136
Asn Ser Ala Val Ile Ala Gln Gln Arg Arg Lys Pro Asp Pro Pro Lys           
            230                 235                 240                   

gat gaa aat gaa aga agc acc tgc aat gta gta caa gat gag ttc ttg       1184
Asp Glu Asn Glu Arg Ser Thr Cys Asn Val Val Gln Asp Glu Phe Leu           
        245                 250                 255                       

gat act cct tgc aca aac aga gga ctg cca tta tta aaa aca gat ttt       1232
Asp Thr Pro Cys Thr Asn Arg Gly Leu Pro Leu Leu Lys Thr Asp Phe           
    260                 265                 270                           

gga agc tgc ctt ctg cag cct cct tcc tgc ccc aat gga atg tca gct       1280
Gly Ser Cys Leu Leu Gln Pro Pro Ser Cys Pro Asn Gly Met Ser Ala           
275                 280                 285                 290           

gaa aat ggc ctg gag aag agt ggt ttt tca caa cat caa aac aaa agt       1328
Glu Asn Gly Leu Glu Lys Ser Gly Phe Ser Gln His Gln Asn Lys Ser           
                295                 300                 305               

cca cca aag gtc aag gca gaa gat ggc atg cag tgt tta caa tta aag       1376
Pro Pro Lys Val Lys Ala Glu Asp Gly Met Gln Cys Leu Gln Leu Lys           
            310                 315                 320                   

gag acc ctg gcc acc cag gaa ccc aca gat aac caa gtc aga ctt cgt       1424
Glu Thr Leu Ala Thr Gln Glu Pro Thr Asp Asn Gln Val Arg Leu Arg           
        325                 330                 335                       

aag aga aag gaa ata aga gaa gat cga gat agg gcg cgg ctg gac tcc       1472
Lys Arg Lys Glu Ile Arg Glu Asp Arg Asp Arg Ala Arg Leu Asp Ser           
    340                 345                 350                           

atg gtg ctg ctg att atg aaa ctg gac cag ctt gat cag gac ata gaa       1520
Met Val Leu Leu Ile Met Lys Leu Asp Gln Leu Asp Gln Asp Ile Glu           
355                 360                 365                 370           

aat gcc ctc agc acc agc tcc tct cca tca ggc aca cca aca aac ctg       1568
Asn Ala Leu Ser Thr Ser Ser Ser Pro Ser Gly Thr Pro Thr Asn Leu           
                375                 380                 385               

cgg cgg cac gtt cct gat ctg gaa tca gga tct gaa agt gga gca gat       1616
Arg Arg His Val Pro Asp Leu Glu Ser Gly Ser Glu Ser Gly Ala Asp           
            390                 395                 400                   

acc att tca gta aat cag aca cga gta aat ttg tct tct gac act gag       1664
Thr Ile Ser Val Asn Gln Thr Arg Val Asn Leu Ser Ser Asp Thr Glu           
        405                 410                 415                       

tcc acg gac ctc cca tct tcc act cca gta gcc aat tct gga acc aaa       1712
Ser Thr Asp Leu Pro Ser Ser Thr Pro Val Ala Asn Ser Gly Thr Lys           
    420                 425                 430                           

ccc aag act acg gct att caa ggt att tca gag aag gaa aag gct gaa       1760
Pro Lys Thr Thr Ala Ile Gln Gly Ile Ser Glu Lys Glu Lys Ala Glu           
435                 440                 445                 450           

att gaa gcc aag gaa gct tgt gat tgg cta cgg gca act ggt ttc ccc       1808
Ile Glu Ala Lys Glu Ala Cys Asp Trp Leu Arg Ala Thr Gly Phe Pro           
                455                 460                 465               

cag tat gca cag ctt tat gaa gat ttc ctg ttc ccc atc gat att tcc       1856
Gln Tyr Ala Gln Leu Tyr Glu Asp Phe Leu Phe Pro Ile Asp Ile Ser           
            470                 475                 480                   

ttg gtc aag aga gag cat gat ttt ttg gac aga gat gcc att gag gct       1904
Leu Val Lys Arg Glu His Asp Phe Leu Asp Arg Asp Ala Ile Glu Ala           
        485                 490                 495                       

cta tgc agg cgt cta aat act tta aac aaa tgt gcg gtg atg aag cta       1952
Leu Cys Arg Arg Leu Asn Thr Leu Asn Lys Cys Ala Val Met Lys Leu           
    500                 505                 510                           

gaa att agt cct cat cgg aaa cga agt gac gat tca gac gag gat gag       2000
Glu Ile Ser Pro His Arg Lys Arg Ser Asp Asp Ser Asp Glu Asp Glu           
515                 520                 525                 530           

cct tgt gcc atc agt ggc aaa tgg act ttc caa agg gac agc aag agg       2048
Pro Cys Ala Ile Ser Gly Lys Trp Thr Phe Gln Arg Asp Ser Lys Arg           
                535                 540                 545               

tgg tcc cgg ctt gaa gag ttt gat gtc ttt tct cca aaa caa gac ctg       2096
Trp Ser Arg Leu Glu Glu Phe Asp Val Phe Ser Pro Lys Gln Asp Leu           
            550                 555                 560                   

gtc cct ggg tcc cca gac gac tcc cac ccg aag gac ggc ccc agc ccc       2144
Val Pro Gly Ser Pro Asp Asp Ser His Pro Lys Asp Gly Pro Ser Pro           
        565                 570                 575                       

gga ggc acg ctg atg gac ctc agc gag cgc cag gag gtg tct tcc gtc       2192
Gly Gly Thr Leu Met Asp Leu Ser Glu Arg Gln Glu Val Ser Ser Val           
    580                 585                 590                           

cgc agc ctc agc agc act ggc agc ctc ccc agc cac gcg ccc ccc agc       2240
Arg Ser Leu Ser Ser Thr Gly Ser Leu Pro Ser His Ala Pro Pro Ser           
595                 600                 605                 610           

gag gat gct gcc acc ccc cgg act aac tcc gtc atc agc gtt tgc tcc       2288
Glu Asp Ala Ala Thr Pro Arg Thr Asn Ser Val Ile Ser Val Cys Ser           
                615                 620                 625               

tcc agc aac ttg gca ggc aat gac gac tct ttc ggc agc ctg ccc tct       2336
Ser Ser Asn Leu Ala Gly Asn Asp Asp Ser Phe Gly Ser Leu Pro Ser           
            630                 635                 640                   

ccc aag gaa ctg tcc agc ttc agc ttc agc atg aaa ggc cac gaa aaa       2384
Pro Lys Glu Leu Ser Ser Phe Ser Phe Ser Met Lys Gly His Glu Lys           
        645                 650                 655                       

act gcc aag tcc aag acg cgc agt ctg ctg aaa cgg atg gag agc ctg       2432
Thr Ala Lys Ser Lys Thr Arg Ser Leu Leu Lys Arg Met Glu Ser Leu           
    660                 665                 670                           

aag ctc aag agc tcc cat cac agc aag cac aaa gcg ccc tca aag ctg       2480
Lys Leu Lys Ser Ser His His Ser Lys His Lys Ala Pro Ser Lys Leu           
675                 680                 685                 690           

ggg ttg atc atc agc ggg ccc atc ttg caa gag ggg atg gat gag gag       2528
Gly Leu Ile Ile Ser Gly Pro Ile Leu Gln Glu Gly Met Asp Glu Glu           
                695                 700                 705               

aag ctg aag cag ctc aac tgc gtg gag atc tcc gcc ctc aat ggc aac       2576
Lys Leu Lys Gln Leu Asn Cys Val Glu Ile Ser Ala Leu Asn Gly Asn           
            710                 715                 720                   

cgc atc aac gtc ccc atg gta cga aag agg agc gtt tcc aac tcc acg       2624
Arg Ile Asn Val Pro Met Val Arg Lys Arg Ser Val Ser Asn Ser Thr           
        725                 730                 735                       

cag acc agc agc agc agc agc cag tcg gag acc agc agc gcg gtc agc       2672
Gln Thr Ser Ser Ser Ser Ser Gln Ser Glu Thr Ser Ser Ala Val Ser           
    740                 745                 750                           

acg ccc agc cct gtt acg agg acc cgg agc ctc agt gcg tgc aac aag       2720
Thr Pro Ser Pro Val Thr Arg Thr Arg Ser Leu Ser Ala Cys Asn Lys           
755                 760                 765                 770           

cgg gtg ggc atg tac tta gag ggc ttc gat cct ttc aat cag tca aca       2768
Arg Val Gly Met Tyr Leu Glu Gly Phe Asp Pro Phe Asn Gln Ser Thr           
                775                 780                 785               

ttt aac aac gtg gtg gag cag aac ttt aag aac cgc gag agc tac cca       2816
Phe Asn Asn Val Val Glu Gln Asn Phe Lys Asn Arg Glu Ser Tyr Pro           
            790                 795                 800                   

gag gac acg gtg ttc tac atc cct gaa gat cac aag cct ggc act ttc       2864
Glu Asp Thr Val Phe Tyr Ile Pro Glu Asp His Lys Pro Gly Thr Phe           
        805                 810                 815                       

ccc aaa gct ctc acc aat ggc agt ttc tcc ccc tcg ggg aat aac ggc       2912
Pro Lys Ala Leu Thr Asn Gly Ser Phe Ser Pro Ser Gly Asn Asn Gly           
    820                 825                 830                           

tct gtg aac tgg agg acg gga agc ttc cac ggc cct ggc cac atc agc       2960
Ser Val Asn Trp Arg Thr Gly Ser Phe His Gly Pro Gly His Ile Ser           
835                 840                 845                 850           

ctc agg agg gaa aac agt agc gac agc ccc aag gaa ctg aag aga cgc       3008
Leu Arg Arg Glu Asn Ser Ser Asp Ser Pro Lys Glu Leu Lys Arg Arg           
                855                 860                 865               

aat tct tcc agc tcc atg agc agc cgc ctg agc atc tac gac aac gtg       3056
Asn Ser Ser Ser Ser Met Ser Ser Arg Leu Ser Ile Tyr Asp Asn Val           
            870                 875                 880                   

ccg ggc tcc atc ctc tac tcc agt tca ggg gac ctg gcg gat ctg gag       3104
Pro Gly Ser Ile Leu Tyr Ser Ser Ser Gly Asp Leu Ala Asp Leu Glu           
        885                 890                 895                       

aac gag gac atc ttc ccc gag ctg gac gac atc ctc tac cac gtg aag       3152
Asn Glu Asp Ile Phe Pro Glu Leu Asp Asp Ile Leu Tyr His Val Lys           
    900                 905                 910                           

ggg atg cag cgg ata gtc aat cag tgg tcg gag aag ttt tct gat gag       3200
Gly Met Gln Arg Ile Val Asn Gln Trp Ser Glu Lys Phe Ser Asp Glu           
915                 920                 925                 930           

gga gat tcg gac tca gcc ctg gac tcg gtc tct ccc tgc ccg tcc tct       3248
Gly Asp Ser Asp Ser Ala Leu Asp Ser Val Ser Pro Cys Pro Ser Ser           
                935                 940                 945               

cca aaa cag ata cac ctg gat gtg gac aac gac cga acc aca ccc agc       3296
Pro Lys Gln Ile His Leu Asp Val Asp Asn Asp Arg Thr Thr Pro Ser           
            950                 955                 960                   

gac ctg gac agc aca ggc aac tcc ctg aat gaa ccg gaa gag ccc tcc       3344
Asp Leu Asp Ser Thr Gly Asn Ser Leu Asn Glu Pro Glu Glu Pro Ser           
        965                 970                 975                       

gag atc ccg gaa aga agg gat tct ggg gtt ggg gct tcc cta acc agg       3392
Glu Ile Pro Glu Arg Arg Asp Ser Gly Val Gly Ala Ser Leu Thr Arg           
    980                 985                 990                           

tcc aac agg cac cga ctg  aga tgg cac agt ttc  cag agc tca cat         3437
Ser Asn Arg His Arg Leu  Arg Trp His Ser Phe  Gln Ser Ser His             
995                 1000                 1005                             

cgg  cca agc ctc aac tct  gta tca cta cag att  aac tgc cag tct        3482
Arg  Pro Ser Leu Asn Ser  Val Ser Leu Gln Ile  Asn Cys Gln Ser            
1010                 1015                 1020                            

gtg  gcc cag atg aac ctg  ctg cag aaa tac tca  ctc cta aag cta        3527
Val  Ala Gln Met Asn Leu  Leu Gln Lys Tyr Ser  Leu Leu Lys Leu            
1025                 1030                 1035                            

acg  gcc ctg ctg gag aaa  tac aca cct tct aac  aag cat ggt ttt        3572
Thr  Ala Leu Leu Glu Lys  Tyr Thr Pro Ser Asn  Lys His Gly Phe            
1040                 1045                 1050                            

agc  tgg gcc gtg ccc aag  ttc atg aag agg atc  aag gtt cca gac        3617
Ser  Trp Ala Val Pro Lys  Phe Met Lys Arg Ile  Lys Val Pro Asp            
1055                 1060                 1065                            

tac  aag gac cgg agt gtg  ttt ggg gtc cca ctg  acg gtc aac gtg        3662
Tyr  Lys Asp Arg Ser Val  Phe Gly Val Pro Leu  Thr Val Asn Val            
1070                 1075                 1080                            

cag  cgc aca gga caa ccg  ttg cct cag agc atc  cag cag gcc atg        3707
Gln  Arg Thr Gly Gln Pro  Leu Pro Gln Ser Ile  Gln Gln Ala Met            
1085                 1090                 1095                            

cga  tac ctc cgg aac cat  tgt ttg gat cag gtt  ggg ctc ttc aga        3752
Arg  Tyr Leu Arg Asn His  Cys Leu Asp Gln Val  Gly Leu Phe Arg            
1100                 1105                 1110                            

aaa  tcg ggg gtc aag tcc  cgg att cag gct ctg  cgc cag atg aat        3797
Lys  Ser Gly Val Lys Ser  Arg Ile Gln Ala Leu  Arg Gln Met Asn            
1115                 1120                 1125                            

gaa  ggt gcc ata gac tgt  gtc aac tac gaa gga  cag tct gct tat        3842
Glu  Gly Ala Ile Asp Cys  Val Asn Tyr Glu Gly  Gln Ser Ala Tyr            
1130                 1135                 1140                            

gac  gtg gca gac atg ctg  aag cag tat ttt cga  gat ctt cct gag        3887
Asp  Val Ala Asp Met Leu  Lys Gln Tyr Phe Arg  Asp Leu Pro Glu            
1145                 1150                 1155                            

cca  cta atg acg aac aaa  ctc tcg gaa acc ttt  cta cag atc tac        3932
Pro  Leu Met Thr Asn Lys  Leu Ser Glu Thr Phe  Leu Gln Ile Tyr            
1160                 1165                 1170                            

caa  tat gtg ccc aag gac  cag cgc ctg cag gcc  atc aag gct gcc        3977
Gln  Tyr Val Pro Lys Asp  Gln Arg Leu Gln Ala  Ile Lys Ala Ala            
1175                 1180                 1185                            

atc  atg ctg ctg cct gac  gag aac cgg gag gtt  ctg cag acc ctg        4022
Ile  Met Leu Leu Pro Asp  Glu Asn Arg Glu Val  Leu Gln Thr Leu            
1190                 1195                 1200                            

ctt  tat ttc ctg agc gat  gtc aca gca gcc gta  aaa gaa aac cag        4067
Leu  Tyr Phe Leu Ser Asp  Val Thr Ala Ala Val  Lys Glu Asn Gln            
1205                 1210                 1215                            

atg  acc cca acc aac ctg  gcc gtg tgc tta gcg  cct tcc ctc ttc        4112
Met  Thr Pro Thr Asn Leu  Ala Val Cys Leu Ala  Pro Ser Leu Phe            
1220                 1225                 1230                            

cat  ctc aac acc ctg aag  aga gag aat tcc tct  ccc agg gta atg        4157
His  Leu Asn Thr Leu Lys  Arg Glu Asn Ser Ser  Pro Arg Val Met            
1235                 1240                 1245                            

caa  aga aaa caa agt ttg  ggc aaa cca gat cag  aaa gat ttg aat        4202
Gln  Arg Lys Gln Ser Leu  Gly Lys Pro Asp Gln  Lys Asp Leu Asn            
1250                 1255                 1260                            

gaa  aac cta gct gcc act  caa ggg ctg gcc cat  atg atc gcc gag        4247
Glu  Asn Leu Ala Ala Thr  Gln Gly Leu Ala His  Met Ile Ala Glu            
1265                 1270                 1275                            

tgc  aag aag ctt ttc cag  gtt ccc gag gaa atg  agc cga tgt cgt        4292
Cys  Lys Lys Leu Phe Gln  Val Pro Glu Glu Met  Ser Arg Cys Arg            
1280                 1285                 1290                            

aat  tcc tat acc gaa caa  gag ctg aag ccc ctc  act ctg gaa gca        4337
Asn  Ser Tyr Thr Glu Gln  Glu Leu Lys Pro Leu  Thr Leu Glu Ala            
1295                 1300                 1305                            

ctc  ggg cac ctg ggt aat  gat gac tca gct gac  tac caa cac ttc        4382
Leu  Gly His Leu Gly Asn  Asp Asp Ser Ala Asp  Tyr Gln His Phe            
1310                 1315                 1320                            

ctc  cag gac tgt gtg gat  ggc ctg ttt aaa gaa  gtc aaa gag aag        4427
Leu  Gln Asp Cys Val Asp  Gly Leu Phe Lys Glu  Val Lys Glu Lys            
1325                 1330                 1335                            

ttt  aaa ggc tgg gtc agc  tac tcc act tcg gag  cag gct gag ctg        4472
Phe  Lys Gly Trp Val Ser  Tyr Ser Thr Ser Glu  Gln Ala Glu Leu            
1340                 1345                 1350                            

tcc  tat aag aag gtg agc  gaa gga ccc cct ctg  agg ctt tgg agg        4517
Ser  Tyr Lys Lys Val Ser  Glu Gly Pro Pro Leu  Arg Leu Trp Arg            
1355                 1360                 1365                            

tca  gtc att gaa gtc cct  gct gtg cca gag gaa  atc tta aag cgc        4562
Ser  Val Ile Glu Val Pro  Ala Val Pro Glu Glu  Ile Leu Lys Arg            
1370                 1375                 1380                            

cta  ctt aaa gaa cag cac  ctc tgg gat gta gac  ctg ttg gat tca        4607
Leu  Leu Lys Glu Gln His  Leu Trp Asp Val Asp  Leu Leu Asp Ser            
1385                 1390                 1395                            

aaa  gtg atc gaa att ctg  gac agc caa act gaa  att tac cag tat        4652
Lys  Val Ile Glu Ile Leu  Asp Ser Gln Thr Glu  Ile Tyr Gln Tyr            
1400                 1405                 1410                            

gtc  caa aac agt atg gca  cct cat cct gct cga  gac tac gtt gtt        4697
Val  Gln Asn Ser Met Ala  Pro His Pro Ala Arg  Asp Tyr Val Val            
1415                 1420                 1425                            

tta  aga acc tgg agg act  aat tta ccc aaa gga  gcc tgt gcc ctt        4742
Leu  Arg Thr Trp Arg Thr  Asn Leu Pro Lys Gly  Ala Cys Ala Leu            
1430                 1435                 1440                            

tta  cta acc tct gtg gat  cac gat cgc gca cct  gtg gtg ggt gtg        4787
Leu  Leu Thr Ser Val Asp  His Asp Arg Ala Pro  Val Val Gly Val            
1445                 1450                 1455                            

agg  gtt aat gtg ctc ttg  tcc agg tat ttg att  gaa ccc tgt ggg        4832
Arg  Val Asn Val Leu Leu  Ser Arg Tyr Leu Ile  Glu Pro Cys Gly            
1460                 1465                 1470                            

cca  gga aaa tcc aaa ctc  acc tac atg tgc aga  gtt gac tta agg        4877
Pro  Gly Lys Ser Lys Leu  Thr Tyr Met Cys Arg  Val Asp Leu Arg            
1475                 1480                 1485                            

ggc  cac atg cca gaa tgg  tac aca aaa tct ttt  gga cat ttg tgt        4922
Gly  His Met Pro Glu Trp  Tyr Thr Lys Ser Phe  Gly His Leu Cys            
1490                 1495                 1500                            

gca  gct gaa gtt gta aag  atc cgg gat tcc ttc  agt aac cag aac        4967
Ala  Ala Glu Val Val Lys  Ile Arg Asp Ser Phe  Ser Asn Gln Asn            
1505                 1510                 1515                            

act  gaa acc aaa gac acc  aaa tct agg tga tcactgaagc aacgcaaccg       5017
Thr  Glu Thr Lys Asp Thr  Lys Ser Arg                                     
1520                 1525                                                 

cttccaccac catggtgttt gtttctagaa cttttgccag tccttgaaga atgggttctg     5077

tgtctaatcc tgaaacaaag aaaactacaa gctggagtgt aggaattgac tatagcaatt     5137

tgatacattt ttaaagctgc ttcctgtttg ttgagggtct gtattcatag accttgactg     5197

gaatatgtaa gactgtgcaa aaaaaaaaaa aaaatttatg tgtattctta ttcagattgc     5257

ttctgagaag caaaactctt taaatacatt atggaagata atgaagatac ttcattctct     5317

tgtgatatca gtgtatgcgt acctgtgtcg ctttatttgc agtgtgttga gggactggtg     5377

tatccactgg aatagttggt actcttggat gtgttttctc accaagatga gcaaagaaag     5437

gtttgcacag aggagtgtga atgtgtgttt gttgctggct gaatggcaat agatgtctaa     5497

ggtggattca gtgtctggca cactgagaca cctccaagaa ggagattgat gcatcaggtt     5557

cagtttaacc tggaatatct gactacccct gaatccaccc agaaaggggg cccaacaccc     5617

ttgtccattt atgggtattt tttttcgaag ttattaagca tattcctttt ccacgaacct     5677

cttctgtact ttgattgtaa taggttggct cttacaccca ttccaaatgc agtttatttt     5737

tagacccgat tgcaaatagt gatgtagttt taaccagtat ggattagttc agggatgaac     5797

tgctccctct agccttactg gctctgatcc acagggtttt gttttgtttt gttttgtttt     5857

ttgtttaagt cgagatataa aaactgaaca cgataacact tactcttaaa tcaagcatca     5917

acactttttc cctgttagaa ttctttgcat ttttgtgttt gtaacagaaa cgccttaaga     5977

cactatgttt gggaatatag gaaactatgt gtgtcccaag gaaatccctg taaatttaac     6037

tcacctacaa aaggcttttt ccccgccttt ggttgttaac ggcattcctg aaagccacat     6097

gtgtttattc attgggcttg ttcttatcag caaataggtt ttctggtttt atgacttttt     6157

gtcttatttt atttttccta catttctttt tttttttttt tcctttagaa tgccctggaa     6217

atatatttaa gtggtaatga aaaatagtaa tcatagtaaa acgcaacaag aagaaaacca     6277

acccaaacca gtgaagtttt ttagaacctt tagaagggtg gtctttattc aggttttact     6337

gtaatggtaa ggattgactc aagagacagt attagtaaat ttattgtgta tggatcaaaa     6397

gtgaataatg tatgaatgag agctgtaaga aggattttta ttttgttata atttagttac     6457

cattttcagt gttatttcaa aggttctttg aagaattttg gggcagggca tcagattaga     6517

gttttaaaat ttgagtattt tggatatcag tgttcctcat gaagatatac atggatattc     6577

aattttgatg gcttccagat ttgtaagatt gtatgttgta tataccattc tattaagaaa     6637

catgtccact gtgctttcaa acatagataa agcatgataa agattattat ttaagatata     6697

cttgtattta tacctcagat attcttttgg gttttgtacc tcaaggcttt tttcttctta     6757

ttgtaaatac actttacgtg aatacagtct aagtgaagaa aataaataaa aggaagaggt     6817

ttataacttg ctctatatct gtacagatta taatcaataa gtgcactatt attaaatgtt     6877

taaagtaagg gaaaagtctg ggctgccttc cttaatattg catctcactc ccacccttaa     6937

aaccacagat tgcaaagcat agcattttag catcaactac aatcaaaaga gcgatttgct     6997

gaaggaaaaa tcggactgca aatcattcca aggccaaact gcaactgagc cacccactcc     7057

caaacaggaa accctggtga aggttcagga agcacggaga ttctctccaa caaaggtcca     7117

gttaggaaac gacgctgaga ggatgacgac aacgtgcaac agcagaaaga tgcttgcaag     7177

cagagtcagg gtcaccagtg aatgccacaa aagttctctt tcccactgtt taatttgaca     7237

agagaagaat ttgaaggata tgaacatttt caagaactct gctgaggtca cttagagcgc     7297

catcacaact tatttgtgtg actaattgcc tagattgtaa gctctttgag ggcagggctt     7357

gtctcttaca catctttata atcccctgca gcggctttca gtattttgta cttgtaggca     7417

cctaataaat ttattatttg ctatactg                                        7445


<210>  784
<211>  1528
<212>  PRT
<213>  Homo sapiens

<400>  784

Met Ser Val Ala Ile Arg Lys Arg Ser Trp Glu Glu His Val Thr His 
1               5                   10                  15      


Trp Met Gly Gln Pro Phe Asn Ser Asp Asp Arg Asn Thr Ala Cys His 
            20                  25                  30          


His Gly Leu Val Ala Asp Ser Leu Gln Ala Ser Met Glu Lys Asp Ala 
        35                  40                  45              


Thr Leu Asn Val Asp Arg Lys Glu Lys Cys Val Ser Leu Pro Asp Cys 
    50                  55                  60                  


Cys His Gly Ser Glu Leu Arg Asp Phe Pro Gly Arg Pro Met Gly His 
65                  70                  75                  80  


Leu Ser Lys Asp Val Asp Glu Asn Asp Ser His Glu Gly Glu Asp Gln 
                85                  90                  95      


Phe Leu Ser Leu Glu Ala Ser Thr Glu Thr Leu Val His Val Ser Asp 
            100                 105                 110         


Glu Asp Asn Asn Ala Asp Leu Cys Leu Thr Asp Asp Lys Gln Val Leu 
        115                 120                 125             


Asn Thr Gln Gly Gln Lys Thr Ser Gly Gln His Met Ile Gln Gly Ala 
    130                 135                 140                 


Gly Ser Leu Glu Lys Ala Leu Pro Ile Ile Gln Ser Asn Gln Val Ser 
145                 150                 155                 160 


Ser Asn Ser Trp Gly Ile Ala Gly Glu Thr Glu Leu Ala Leu Val Lys 
                165                 170                 175     


Glu Ser Gly Glu Arg Lys Val Thr Asp Ser Ile Ser Lys Ser Leu Glu 
            180                 185                 190         


Leu Cys Asn Glu Ile Ser Leu Ser Glu Ile Lys Asp Ala Pro Lys Val 
        195                 200                 205             


Asn Ala Val Asp Thr Leu Asn Val Lys Asp Ile Ala Pro Glu Lys Gln 
    210                 215                 220                 


Leu Leu Asn Ser Ala Val Ile Ala Gln Gln Arg Arg Lys Pro Asp Pro 
225                 230                 235                 240 


Pro Lys Asp Glu Asn Glu Arg Ser Thr Cys Asn Val Val Gln Asp Glu 
                245                 250                 255     


Phe Leu Asp Thr Pro Cys Thr Asn Arg Gly Leu Pro Leu Leu Lys Thr 
            260                 265                 270         


Asp Phe Gly Ser Cys Leu Leu Gln Pro Pro Ser Cys Pro Asn Gly Met 
        275                 280                 285             


Ser Ala Glu Asn Gly Leu Glu Lys Ser Gly Phe Ser Gln His Gln Asn 
    290                 295                 300                 


Lys Ser Pro Pro Lys Val Lys Ala Glu Asp Gly Met Gln Cys Leu Gln 
305                 310                 315                 320 


Leu Lys Glu Thr Leu Ala Thr Gln Glu Pro Thr Asp Asn Gln Val Arg 
                325                 330                 335     


Leu Arg Lys Arg Lys Glu Ile Arg Glu Asp Arg Asp Arg Ala Arg Leu 
            340                 345                 350         


Asp Ser Met Val Leu Leu Ile Met Lys Leu Asp Gln Leu Asp Gln Asp 
        355                 360                 365             


Ile Glu Asn Ala Leu Ser Thr Ser Ser Ser Pro Ser Gly Thr Pro Thr 
    370                 375                 380                 


Asn Leu Arg Arg His Val Pro Asp Leu Glu Ser Gly Ser Glu Ser Gly 
385                 390                 395                 400 


Ala Asp Thr Ile Ser Val Asn Gln Thr Arg Val Asn Leu Ser Ser Asp 
                405                 410                 415     


Thr Glu Ser Thr Asp Leu Pro Ser Ser Thr Pro Val Ala Asn Ser Gly 
            420                 425                 430         


Thr Lys Pro Lys Thr Thr Ala Ile Gln Gly Ile Ser Glu Lys Glu Lys 
        435                 440                 445             


Ala Glu Ile Glu Ala Lys Glu Ala Cys Asp Trp Leu Arg Ala Thr Gly 
    450                 455                 460                 


Phe Pro Gln Tyr Ala Gln Leu Tyr Glu Asp Phe Leu Phe Pro Ile Asp 
465                 470                 475                 480 


Ile Ser Leu Val Lys Arg Glu His Asp Phe Leu Asp Arg Asp Ala Ile 
                485                 490                 495     


Glu Ala Leu Cys Arg Arg Leu Asn Thr Leu Asn Lys Cys Ala Val Met 
            500                 505                 510         


Lys Leu Glu Ile Ser Pro His Arg Lys Arg Ser Asp Asp Ser Asp Glu 
        515                 520                 525             


Asp Glu Pro Cys Ala Ile Ser Gly Lys Trp Thr Phe Gln Arg Asp Ser 
    530                 535                 540                 


Lys Arg Trp Ser Arg Leu Glu Glu Phe Asp Val Phe Ser Pro Lys Gln 
545                 550                 555                 560 


Asp Leu Val Pro Gly Ser Pro Asp Asp Ser His Pro Lys Asp Gly Pro 
                565                 570                 575     


Ser Pro Gly Gly Thr Leu Met Asp Leu Ser Glu Arg Gln Glu Val Ser 
            580                 585                 590         


Ser Val Arg Ser Leu Ser Ser Thr Gly Ser Leu Pro Ser His Ala Pro 
        595                 600                 605             


Pro Ser Glu Asp Ala Ala Thr Pro Arg Thr Asn Ser Val Ile Ser Val 
    610                 615                 620                 


Cys Ser Ser Ser Asn Leu Ala Gly Asn Asp Asp Ser Phe Gly Ser Leu 
625                 630                 635                 640 


Pro Ser Pro Lys Glu Leu Ser Ser Phe Ser Phe Ser Met Lys Gly His 
                645                 650                 655     


Glu Lys Thr Ala Lys Ser Lys Thr Arg Ser Leu Leu Lys Arg Met Glu 
            660                 665                 670         


Ser Leu Lys Leu Lys Ser Ser His His Ser Lys His Lys Ala Pro Ser 
        675                 680                 685             


Lys Leu Gly Leu Ile Ile Ser Gly Pro Ile Leu Gln Glu Gly Met Asp 
    690                 695                 700                 


Glu Glu Lys Leu Lys Gln Leu Asn Cys Val Glu Ile Ser Ala Leu Asn 
705                 710                 715                 720 


Gly Asn Arg Ile Asn Val Pro Met Val Arg Lys Arg Ser Val Ser Asn 
                725                 730                 735     


Ser Thr Gln Thr Ser Ser Ser Ser Ser Gln Ser Glu Thr Ser Ser Ala 
            740                 745                 750         


Val Ser Thr Pro Ser Pro Val Thr Arg Thr Arg Ser Leu Ser Ala Cys 
        755                 760                 765             


Asn Lys Arg Val Gly Met Tyr Leu Glu Gly Phe Asp Pro Phe Asn Gln 
    770                 775                 780                 


Ser Thr Phe Asn Asn Val Val Glu Gln Asn Phe Lys Asn Arg Glu Ser 
785                 790                 795                 800 


Tyr Pro Glu Asp Thr Val Phe Tyr Ile Pro Glu Asp His Lys Pro Gly 
                805                 810                 815     


Thr Phe Pro Lys Ala Leu Thr Asn Gly Ser Phe Ser Pro Ser Gly Asn 
            820                 825                 830         


Asn Gly Ser Val Asn Trp Arg Thr Gly Ser Phe His Gly Pro Gly His 
        835                 840                 845             


Ile Ser Leu Arg Arg Glu Asn Ser Ser Asp Ser Pro Lys Glu Leu Lys 
    850                 855                 860                 


Arg Arg Asn Ser Ser Ser Ser Met Ser Ser Arg Leu Ser Ile Tyr Asp 
865                 870                 875                 880 


Asn Val Pro Gly Ser Ile Leu Tyr Ser Ser Ser Gly Asp Leu Ala Asp 
                885                 890                 895     


Leu Glu Asn Glu Asp Ile Phe Pro Glu Leu Asp Asp Ile Leu Tyr His 
            900                 905                 910         


Val Lys Gly Met Gln Arg Ile Val Asn Gln Trp Ser Glu Lys Phe Ser 
        915                 920                 925             


Asp Glu Gly Asp Ser Asp Ser Ala Leu Asp Ser Val Ser Pro Cys Pro 
    930                 935                 940                 


Ser Ser Pro Lys Gln Ile His Leu Asp Val Asp Asn Asp Arg Thr Thr 
945                 950                 955                 960 


Pro Ser Asp Leu Asp Ser Thr Gly Asn Ser Leu Asn Glu Pro Glu Glu 
                965                 970                 975     


Pro Ser Glu Ile Pro Glu Arg Arg Asp Ser Gly Val Gly Ala Ser Leu 
            980                 985                 990         


Thr Arg Ser Asn Arg His Arg Leu  Arg Trp His Ser Phe  Gln Ser Ser 
        995                 1000                 1005             


His Arg  Pro Ser Leu Asn Ser  Val Ser Leu Gln Ile  Asn Cys Gln 
    1010                 1015                 1020             


Ser Val  Ala Gln Met Asn Leu  Leu Gln Lys Tyr Ser  Leu Leu Lys 
    1025                 1030                 1035             


Leu Thr  Ala Leu Leu Glu Lys  Tyr Thr Pro Ser Asn  Lys His Gly 
    1040                 1045                 1050             


Phe Ser  Trp Ala Val Pro Lys  Phe Met Lys Arg Ile  Lys Val Pro 
    1055                 1060                 1065             


Asp Tyr  Lys Asp Arg Ser Val  Phe Gly Val Pro Leu  Thr Val Asn 
    1070                 1075                 1080             


Val Gln  Arg Thr Gly Gln Pro  Leu Pro Gln Ser Ile  Gln Gln Ala 
    1085                 1090                 1095             


Met Arg  Tyr Leu Arg Asn His  Cys Leu Asp Gln Val  Gly Leu Phe 
    1100                 1105                 1110             


Arg Lys  Ser Gly Val Lys Ser  Arg Ile Gln Ala Leu  Arg Gln Met 
    1115                 1120                 1125             


Asn Glu  Gly Ala Ile Asp Cys  Val Asn Tyr Glu Gly  Gln Ser Ala 
    1130                 1135                 1140             


Tyr Asp  Val Ala Asp Met Leu  Lys Gln Tyr Phe Arg  Asp Leu Pro 
    1145                 1150                 1155             


Glu Pro  Leu Met Thr Asn Lys  Leu Ser Glu Thr Phe  Leu Gln Ile 
    1160                 1165                 1170             


Tyr Gln  Tyr Val Pro Lys Asp  Gln Arg Leu Gln Ala  Ile Lys Ala 
    1175                 1180                 1185             


Ala Ile  Met Leu Leu Pro Asp  Glu Asn Arg Glu Val  Leu Gln Thr 
    1190                 1195                 1200             


Leu Leu  Tyr Phe Leu Ser Asp  Val Thr Ala Ala Val  Lys Glu Asn 
    1205                 1210                 1215             


Gln Met  Thr Pro Thr Asn Leu  Ala Val Cys Leu Ala  Pro Ser Leu 
    1220                 1225                 1230             


Phe His  Leu Asn Thr Leu Lys  Arg Glu Asn Ser Ser  Pro Arg Val 
    1235                 1240                 1245             


Met Gln  Arg Lys Gln Ser Leu  Gly Lys Pro Asp Gln  Lys Asp Leu 
    1250                 1255                 1260             


Asn Glu  Asn Leu Ala Ala Thr  Gln Gly Leu Ala His  Met Ile Ala 
    1265                 1270                 1275             


Glu Cys  Lys Lys Leu Phe Gln  Val Pro Glu Glu Met  Ser Arg Cys 
    1280                 1285                 1290             


Arg Asn  Ser Tyr Thr Glu Gln  Glu Leu Lys Pro Leu  Thr Leu Glu 
    1295                 1300                 1305             


Ala Leu  Gly His Leu Gly Asn  Asp Asp Ser Ala Asp  Tyr Gln His 
    1310                 1315                 1320             


Phe Leu  Gln Asp Cys Val Asp  Gly Leu Phe Lys Glu  Val Lys Glu 
    1325                 1330                 1335             


Lys Phe  Lys Gly Trp Val Ser  Tyr Ser Thr Ser Glu  Gln Ala Glu 
    1340                 1345                 1350             


Leu Ser  Tyr Lys Lys Val Ser  Glu Gly Pro Pro Leu  Arg Leu Trp 
    1355                 1360                 1365             


Arg Ser  Val Ile Glu Val Pro  Ala Val Pro Glu Glu  Ile Leu Lys 
    1370                 1375                 1380             


Arg Leu  Leu Lys Glu Gln His  Leu Trp Asp Val Asp  Leu Leu Asp 
    1385                 1390                 1395             


Ser Lys  Val Ile Glu Ile Leu  Asp Ser Gln Thr Glu  Ile Tyr Gln 
    1400                 1405                 1410             


Tyr Val  Gln Asn Ser Met Ala  Pro His Pro Ala Arg  Asp Tyr Val 
    1415                 1420                 1425             


Val Leu  Arg Thr Trp Arg Thr  Asn Leu Pro Lys Gly  Ala Cys Ala 
    1430                 1435                 1440             


Leu Leu  Leu Thr Ser Val Asp  His Asp Arg Ala Pro  Val Val Gly 
    1445                 1450                 1455             


Val Arg  Val Asn Val Leu Leu  Ser Arg Tyr Leu Ile  Glu Pro Cys 
    1460                 1465                 1470             


Gly Pro  Gly Lys Ser Lys Leu  Thr Tyr Met Cys Arg  Val Asp Leu 
    1475                 1480                 1485             


Arg Gly  His Met Pro Glu Trp  Tyr Thr Lys Ser Phe  Gly His Leu 
    1490                 1495                 1500             


Cys Ala  Ala Glu Val Val Lys  Ile Arg Asp Ser Phe  Ser Asn Gln 
    1505                 1510                 1515             


Asn Thr  Glu Thr Lys Asp Thr  Lys Ser Arg 
    1520                 1525             


<210>  785
<211>  904
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (24)..(560)

<400>  785
agtttgaaga aggctcttac agc atg gcc gcc ggt act gca gct gcc tta gcg       53
                          Met Ala Ala Gly Thr Ala Ala Ala Leu Ala         
                          1               5                   10          

ttt ttg agt cag gag agc cga acg cgg gcc ggg ggt gtc ggg ggc cta        101
Phe Leu Ser Gln Glu Ser Arg Thr Arg Ala Gly Gly Val Gly Gly Leu           
                15                  20                  25                

cgg gtc ccg gcc ccg gtc act atg gac agt ttt ttc ttc ggc tgt gag        149
Arg Val Pro Ala Pro Val Thr Met Asp Ser Phe Phe Phe Gly Cys Glu           
            30                  35                  40                    

ctc tcc ggc cac acc cgc tcc ttc acc ttt aag gta gag gaa gag gat        197
Leu Ser Gly His Thr Arg Ser Phe Thr Phe Lys Val Glu Glu Glu Asp           
        45                  50                  55                        

gat gcg gag cac gtg ctg gca cta acc atg ctc tgc ctc acc gag gga        245
Asp Ala Glu His Val Leu Ala Leu Thr Met Leu Cys Leu Thr Glu Gly           
    60                  65                  70                            

gcc aaa gac gag tgt aat gtg gta gaa gtt gtg gcc cgg aac cat gac        293
Ala Lys Asp Glu Cys Asn Val Val Glu Val Val Ala Arg Asn His Asp           
75                  80                  85                  90            

cat cag gag atc gca gtc cct gtg gcc aac ctc aag ctg tcc tgc caa        341
His Gln Glu Ile Ala Val Pro Val Ala Asn Leu Lys Leu Ser Cys Gln           
                95                  100                 105               

ccc atg ctc agt ctg gat gac ttc cag ctc caa cca cct gta acc ttc        389
Pro Met Leu Ser Leu Asp Asp Phe Gln Leu Gln Pro Pro Val Thr Phe           
            110                 115                 120                   

cgc ctg aag tcg ggc tct ggc cct gtg cgg atc act ggg cgg cac cag        437
Arg Leu Lys Ser Gly Ser Gly Pro Val Arg Ile Thr Gly Arg His Gln           
        125                 130                 135                       

att gtt acg atg agc aat gat gtt tct gag gag gag agc gag gaa gag        485
Ile Val Thr Met Ser Asn Asp Val Ser Glu Glu Glu Ser Glu Glu Glu           
    140                 145                 150                           

gaa gag gac agt gat gag gaa gaa gtt gag ctg tgc ccc atc ctt cct        533
Glu Glu Asp Ser Asp Glu Glu Glu Val Glu Leu Cys Pro Ile Leu Pro           
155                 160                 165                 170           

gcc aaa aag cag ggg ggc agg ccc tag ccctcctagg tcagctccat              580
Ala Lys Lys Gln Gly Gly Arg Pro                                           
                175                                                       

gtgccatgca ccgccatgca ccctgttccc tgacaagttt caacaattgt aaatatttct      640

tccttgaaga ggagagcttg ggtgggggtt gggtgggagg gacttgggtc tttggtgcta      700

ggagagggcc tgtgctccac acagccgtgg ttttctgatt ttcaccatgc ccggggcctc      760

ccttcccacc tgcctgtgag aattggaggt tagtgcctga agctcagagc tacacatttt      820

taatagtttt tacatttttg gataaaggtt gaaataaagt ggtgtggagt ttttgcaaaa      880

aaaaaaaaaa aaaaaaaaaa aaaa                                             904


<210>  786
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  786

Met Ala Ala Gly Thr Ala Ala Ala Leu Ala Phe Leu Ser Gln Glu Ser 
1               5                   10                  15      


Arg Thr Arg Ala Gly Gly Val Gly Gly Leu Arg Val Pro Ala Pro Val 
            20                  25                  30          


Thr Met Asp Ser Phe Phe Phe Gly Cys Glu Leu Ser Gly His Thr Arg 
        35                  40                  45              


Ser Phe Thr Phe Lys Val Glu Glu Glu Asp Asp Ala Glu His Val Leu 
    50                  55                  60                  


Ala Leu Thr Met Leu Cys Leu Thr Glu Gly Ala Lys Asp Glu Cys Asn 
65                  70                  75                  80  


Val Val Glu Val Val Ala Arg Asn His Asp His Gln Glu Ile Ala Val 
                85                  90                  95      


Pro Val Ala Asn Leu Lys Leu Ser Cys Gln Pro Met Leu Ser Leu Asp 
            100                 105                 110         


Asp Phe Gln Leu Gln Pro Pro Val Thr Phe Arg Leu Lys Ser Gly Ser 
        115                 120                 125             


Gly Pro Val Arg Ile Thr Gly Arg His Gln Ile Val Thr Met Ser Asn 
    130                 135                 140                 


Asp Val Ser Glu Glu Glu Ser Glu Glu Glu Glu Glu Asp Ser Asp Glu 
145                 150                 155                 160 


Glu Glu Val Glu Leu Cys Pro Ile Leu Pro Ala Lys Lys Gln Gly Gly 
                165                 170                 175     


Arg Pro 
        


<210>  787
<211>  469
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (60)..(392)

<400>  787
agccctccag gacaggctgc atcagaagag gccatcaagc agatcactgt ccttctgcc        59

atg gcc ctg tgg atg cgc ctc ctg ccc ctg ctg gcg ctg ctg gcc ctc        107
Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu           
1               5                   10                  15                

tgg gga cct gac cca gcc gca gcc ttt gtg aac caa cac ctg tgc ggc        155
Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly           
            20                  25                  30                    

tca cac ctg gtg gaa gct ctc tac cta gtg tgc ggg gaa cga ggc ttc        203
Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe           
        35                  40                  45                        

ttc tac aca ccc aag acc cgc cgg gag gca gag gac ctg cag gtg ggg        251
Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly           
    50                  55                  60                            

cag gtg gag ctg ggc ggg ggc cct ggt gca ggc agc ctg cag ccc ttg        299
Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu           
65                  70                  75                  80            

gcc ctg gag ggg tcc ctg cag aag cgt ggc att gtg gaa caa tgc tgt        347
Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys           
                85                  90                  95                

acc agc atc tgc tcc ctc tac cag ctg gag aac tac tgc aac tag            392
Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn                   
            100                 105                 110                   

acgcagcccg caggcagccc cacacccgcc gcctcctgca ccgagagaga tggaataaag      452

cccttgaacc agcaaaa                                                     469


<210>  788
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  788

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  789
<211>  5730
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (499)..(1890)

<400>  789
cctccgcctc cactcgccct cgtgctccct tcagcccctt cgcagctccg tgcgcaaggt       60

cgtgtcccgg aagtgaaggg gccatgttga tgggtgaccc ggggagaggt acccggccag      120

aggcgagtcc tgcggagtgg tagcgcgcac ggcctgcggt gtgacaccca gcccctgcca      180

gtcccccatg gccccgtgga gccgagaggc ggtgctgagt ctctatcggg ctctgttgcg      240

ccagggccga cagcttcgct acactgatcg agacttctac tttgcctcca tccgccgtga      300

attccgaaaa aatcagaagc tagaggacgc tgaggcccgg gagaggcagc tggagaaggg      360

cctggtcttt ctcaacggca aattggggag gatcatttag gatcctccaa gggaaagagg      420

acaaaggtgc cttctgtaga cactcctgct ctcttccatc cccatcttac agatgtatta      480

agaagcctca gatgagca atg gca ggc gct ggt gag cgc aaa ggc aag aag        531
                    Met Ala Gly Ala Gly Glu Arg Lys Gly Lys Lys           
                    1               5                   10                

gat gac aat ggc att ggc acg gcc att gac ttt gtg ctc tcc aat gcc        579
Asp Asp Asn Gly Ile Gly Thr Ala Ile Asp Phe Val Leu Ser Asn Ala           
            15                  20                  25                    

cgg ctg gtg ctg ggg gtg ggt gga gcg gcc atg ctg ggc atc gcc acg        627
Arg Leu Val Leu Gly Val Gly Gly Ala Ala Met Leu Gly Ile Ala Thr           
        30                  35                  40                        

ctg gca gtt aag cgg atg tac gat cgg gcg atc agt gcc cct acc agc        675
Leu Ala Val Lys Arg Met Tyr Asp Arg Ala Ile Ser Ala Pro Thr Ser           
    45                  50                  55                            

ccc acc cgc ctg agc cat tcg ggg aaa agg agc tgg gaa gaa ccc aac        723
Pro Thr Arg Leu Ser His Ser Gly Lys Arg Ser Trp Glu Glu Pro Asn           
60                  65                  70                  75            

tgg atg ggc tcc cca cga ctg ctg aac agg gac atg aag acg ggc ctg        771
Trp Met Gly Ser Pro Arg Leu Leu Asn Arg Asp Met Lys Thr Gly Leu           
                80                  85                  90                

agc cgg tcc ttg cag acc ctt ccc aca gac tcc tcc acc ttc gac aca        819
Ser Arg Ser Leu Gln Thr Leu Pro Thr Asp Ser Ser Thr Phe Asp Thr           
            95                  100                 105                   

gat aca ttc tgc ccg ccc cgg ccc aag cca gtg gcc agg aag ggc cag        867
Asp Thr Phe Cys Pro Pro Arg Pro Lys Pro Val Ala Arg Lys Gly Gln           
        110                 115                 120                       

gta gac ttg aag aag tca cga ctc cgc atg tcc ctg cag gag aaa ctt        915
Val Asp Leu Lys Lys Ser Arg Leu Arg Met Ser Leu Gln Glu Lys Leu           
    125                 130                 135                           

ctt act tac tac cgg aac cgg gca gcc atc cct gct gga gag cag gct        963
Leu Thr Tyr Tyr Arg Asn Arg Ala Ala Ile Pro Ala Gly Glu Gln Ala           
140                 145                 150                 155           

cgg gcc aag caa gct gct gtg gac ata tgt gcc gag ctc cgg agc ttc       1011
Arg Ala Lys Gln Ala Ala Val Asp Ile Cys Ala Glu Leu Arg Ser Phe           
                160                 165                 170               

ctg cgg gcc aag ttg cct gac atg ccg ctt cgg gac atg tac ttg agt       1059
Leu Arg Ala Lys Leu Pro Asp Met Pro Leu Arg Asp Met Tyr Leu Ser           
            175                 180                 185                   

ggc agc ctc tac gat gac ctg cag gtg gtg aca gct gac cac atc caa       1107
Gly Ser Leu Tyr Asp Asp Leu Gln Val Val Thr Ala Asp His Ile Gln           
        190                 195                 200                       

ctc att gtg ccc ctt gtg ctg gag cag aac ctg tgg tca tgt att cct       1155
Leu Ile Val Pro Leu Val Leu Glu Gln Asn Leu Trp Ser Cys Ile Pro           
    205                 210                 215                           

ggt gaa gac acc atc atg aat gtc cct ggc ttc ttc ctg gtg cgt cgt       1203
Gly Glu Asp Thr Ile Met Asn Val Pro Gly Phe Phe Leu Val Arg Arg           
220                 225                 230                 235           

gag aat cca gag tac ttt cct cgt ggg agc agt tac tgg gac cgc tgt       1251
Glu Asn Pro Glu Tyr Phe Pro Arg Gly Ser Ser Tyr Trp Asp Arg Cys           
                240                 245                 250               

gta gta ggg ggc tac ctc tct cca aag aca gtc gca gat aca ttt gag       1299
Val Val Gly Gly Tyr Leu Ser Pro Lys Thr Val Ala Asp Thr Phe Glu           
            255                 260                 265                   

aag gta gtg gct ggc tcc atc aat tgg cca gcc ata ggg tcc ctc ttg       1347
Lys Val Val Ala Gly Ser Ile Asn Trp Pro Ala Ile Gly Ser Leu Leu           
        270                 275                 280                       

gac tat gtg atc cgc ccg gcc cca ccc cca gaa gcc ctc aca ctg gag       1395
Asp Tyr Val Ile Arg Pro Ala Pro Pro Pro Glu Ala Leu Thr Leu Glu           
    285                 290                 295                           

gtg cag tat gag cgt gac aaa cat ctc ttc att gac ttc ctg cca tca       1443
Val Gln Tyr Glu Arg Asp Lys His Leu Phe Ile Asp Phe Leu Pro Ser           
300                 305                 310                 315           

gtg acc ctc ggt gac aca gtc ttg gtg gcc aaa cca cac cgg cta gcc       1491
Val Thr Leu Gly Asp Thr Val Leu Val Ala Lys Pro His Arg Leu Ala           
                320                 325                 330               

cag tat gac aac ctg tgg cgg ctg agc ctg cgt ccc gcg gag acg gca       1539
Gln Tyr Asp Asn Leu Trp Arg Leu Ser Leu Arg Pro Ala Glu Thr Ala           
            335                 340                 345                   

cgc ctg cgg gct ctg gac cag gct gac tcg ggc tgc cga tct ctg tgc       1587
Arg Leu Arg Ala Leu Asp Gln Ala Asp Ser Gly Cys Arg Ser Leu Cys           
        350                 355                 360                       

ctc aag atc ctc aag gcc ata tgc aag tcc acc ccg gct ctg ggc cac       1635
Leu Lys Ile Leu Lys Ala Ile Cys Lys Ser Thr Pro Ala Leu Gly His           
    365                 370                 375                           

ctc act gcc agc cag cta acc aat gtc atc ctc cac ttg gcc cag gag       1683
Leu Thr Ala Ser Gln Leu Thr Asn Val Ile Leu His Leu Ala Gln Glu           
380                 385                 390                 395           

gag gct gac tgg tct ccg gat atg ctg gcc gac cgt ttc ctg cag gcc       1731
Glu Ala Asp Trp Ser Pro Asp Met Leu Ala Asp Arg Phe Leu Gln Ala           
                400                 405                 410               

ttg agg gga ctt atc agc tac tta gag gct gga gtc ctg ccc agt gcc       1779
Leu Arg Gly Leu Ile Ser Tyr Leu Glu Ala Gly Val Leu Pro Ser Ala           
            415                 420                 425                   

cta aac ccc aag gtg aac tta ttt gca gag ctc acc cct gaa gaa ata       1827
Leu Asn Pro Lys Val Asn Leu Phe Ala Glu Leu Thr Pro Glu Glu Ile           
        430                 435                 440                       

gac gaa tta gga tac act ctg tat tgc tca ttg tct gag cca gag gtg       1875
Asp Glu Leu Gly Tyr Thr Leu Tyr Cys Ser Leu Ser Glu Pro Glu Val           
    445                 450                 455                           

ctg ctg cag acg tag ggcaggtgaa ggccaaagcg ggtgttggtg gtcaggccct       1930
Leu Leu Gln Thr                                                           
460                                                                       

ggattctccg ttagatacac ttggctacct agttggtgcc tcacagggtt cctgctgcct     1990

ggtgtcttgc tgatcatcac cctggtcact tcatgctgat tagaatgaca tctctttcgt     2050

ctcctatttt gttacccaac tcttcctatt tttgttacca atcactgtgc tctctgccgc     2110

cccctggctc caggctaatt tttctggaat gaattgagaa ggtggcgtgc tggcctgagc     2170

tgatggacca cttggtgttt tgcgttttgg cccatgtttg ctgcctctat ctggtctgcc     2230

ttgcccgttt gcctgttcct attcagtgtc ttttctattt tttcctctct cgttcatgcc     2290

ttctgttttg ctcttgtccc tggagcatat ctgcctaatt aagatgttgc cttttagttg     2350

aatgccactg aagagctgtg atagcatgtt tcaaagctga actctacaga gcgagtgctg     2410

agacagtatt tagggtttct gggagtgagg ctggtagaag agttggcctt tgaccacggt     2470

tcctggagta gaagtccatc ctccccccaa cctcctgacc cattcataaa tgctgagaat     2530

gtctctcatg ggaacactgt taatgaccca cacaggataa gctgaatgca aagttatttg     2590

caggttgaat ttcttggtgg ctattagcag aagtgcagag tagggaacca gagctggtta     2650

agggcctagt gaagggtttg tgtgcccagt gtctgctcgt catctgtggc tgcaggggtc     2710

agacagacaa ggatggggac tgccagggca ccacttcatc atgaatgctg gttttcacac     2770

cttttcctta ttttattgcc aatcaggaca aggccttgaa ggaacgcagc cttagacatc     2830

aggtgaggat gatggaggta gacagtcgac tgaatgtcag ctggaaaatc cagtcactag     2890

ttggggtttg gtggccatgt tttctaccca gacaggccct gcttttctag gatgtggcct     2950

tagagcaaga acagacccaa cagccagccc ttcatcctcc agcgtctgcc ataggaatgt     3010

gagaggggtg tttgctgagc gctccgggca cggccagagg gcaagtgagc atgcacggac     3070

ctcttccccc tgtcctgttt ctcacccagc acctggggag atcggtgcta ccaaggaaga     3130

gagcacacag ataagacaga ggggaggagg tgggcatttc ctacattcct ccttgtttgc     3190

cgctgctgag attgcagtat ttattgcaat gtaaatgtat cctgaaggtg gggaggaatg     3250

tttaatctac catgtccgtg tgtcatcttg gtttgtgttt ttccctgttt gtagcaagac     3310

tctgatgata attctgtttc tcatctgccc attcagtatt ttgttttcct tccgtcaagt     3370

tgtcttattt tttcaatgac tacctctcca tcattgaggt tctggtgaag ctctctgcag     3430

ctgtctcatt ccttcccaac gatagtaaca ggaaatgact ctttagcatc gatacctcaa     3490

catcaattta gggtagagat tcctgcccct cttttgtcac agattaggaa attgagaact     3550

agggttaacc ttgactatat ttagaggtct ttttgcctct tttcccctta acaaggattt     3610

cttatggtgg tttcagtttc atttgcataa aggtattgag agggaacaaa aaacataaag     3670

ctgagaatct tgagagagct catctaccct gtctgttggt cagactcaaa tgagagttaa     3730

aaaaaaaaaa aaaaatctgt atgcctgagt accatcctgg atgaatctag aaggtatggg     3790

gtagagcttg acagggttcc tgtgtaccca ctgggtatcc gttagaggta agggagagga     3850

gaggattgat agagtgttgc aaaagtatag attattcatt gagataaagg atttggtttc     3910

cctgccatga gtattaaaaa aatttaagtt ttcccaagct tgcatctctg accaaatttc     3970

acataaaaca ttggaaggag gctgggtgcg gtggctcatg cttgtaatcc cagcactggg     4030

aagctaaggc gggtggatca cttgaggtca ggagttcgag accagcctgg ccaacatggt     4090

gaaaccccgt ctccacgaaa aagataaaaa taagctgggc gtggtggcag gcgcctataa     4150

tcccagctac tcgggaggct gaggcaggag aataacttaa acccgggagg cggaggttac     4210

agtgagctga gatcgtgcca ctgcactcca gcctgggtga cagagtgaga ccctatttca     4270

aaaaaataaa aattggaaga agagcttaaa aaagataaga ttttaaagag tcccaagtta     4330

tttaagttga gtgtaattgt catttaagga aggcaaatga gtttatcatc cttcttaaag     4390

agcatctctt ttaactgttg gacaaaacca taactttgtc attttacaag gaagaacctc     4450

ttaagaagtc ctcagaacca gaagcaatgt gaactctcag cgctggtcct ggtgggtttg     4510

ctgaccatga ctgggcaagc cgttcttttt gctgccatct tcctcatcat aaagtgtgga     4570

acataggcaa ttgctttgag attcttggat agaagaggac aacattctgc acctgccccc     4630

ttttttaaat ctttggggaa agatgagtaa ctttccccac tactctgcct tcctgttcag     4690

taactcttac ttttgcctga agtaacagca tcttctactt ctccatctag agatttttgt     4750

gtgtgtgcca tcaaggttag caaactttat acgtagccta acacttaaaa aatgcactca     4810

ttatcttaaa cctaataaat tccagagttt attttggttc tcctctgttg cccttcctaa     4870

aaaatgagct gaagatgaca gtatttttct ttacatgctt ggttatgact tttaaagttt     4930

tatttaaata aatgttgaag ctcaagttta aagaagcgtt gcagaggccc acggtctcct     4990

gggtcccggc cacctgtcca tattccacat ttgctgactg tgctccctgc actccactca     5050

agttgagagt tcaaatagtc ttgaagggga atcagcttca ggatggaagg acccaggaga     5110

ggccccgagg tgggagggtt ctgtaaatac agactactgc gagtgtccag agctctctgc     5170

catgatactt ccttgggact gacttggctg agaacgtgtt ctgtcagagg atttgttaga     5230

actctgccct tttgtctgaa actcaaggcc aaggagaatg ataggagact taggacagag     5290

ctgacccttg caccaggctg ggaggctgca gcccttttag atgccactta ctgtaagtgg     5350

ccagaatacc agagaggtgg gttccatggt caaatgcaca gtaggtgttt acctttacat     5410

ttggatcacc ttgtagtctt taaattcttg gtccctgagg ccaagtccac aacttgcctt     5470

ctagtcactt gcctgcccgc agtggtggtg gatgtgttag ctggtagatt tggaatcagt     5530

caccagtctt tctgtactgt cttggttagc tctatataag taggggcagc ttagccctga     5590

ggcccagaga cctgctgtcc tttttctcct tgagggagga aataaaactg cggaatacaa     5650

tgtccttcca tagcatggga agaagaaaat aaacatctcc tttccaacaa aaaaaaaaaa     5710

aaaaaaaaaa aaaaaaaaaa                                                 5730


<210>  790
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  790

Met Ala Gly Ala Gly Glu Arg Lys Gly Lys Lys Asp Asp Asn Gly Ile 
1               5                   10                  15      


Gly Thr Ala Ile Asp Phe Val Leu Ser Asn Ala Arg Leu Val Leu Gly 
            20                  25                  30          


Val Gly Gly Ala Ala Met Leu Gly Ile Ala Thr Leu Ala Val Lys Arg 
        35                  40                  45              


Met Tyr Asp Arg Ala Ile Ser Ala Pro Thr Ser Pro Thr Arg Leu Ser 
    50                  55                  60                  


His Ser Gly Lys Arg Ser Trp Glu Glu Pro Asn Trp Met Gly Ser Pro 
65                  70                  75                  80  


Arg Leu Leu Asn Arg Asp Met Lys Thr Gly Leu Ser Arg Ser Leu Gln 
                85                  90                  95      


Thr Leu Pro Thr Asp Ser Ser Thr Phe Asp Thr Asp Thr Phe Cys Pro 
            100                 105                 110         


Pro Arg Pro Lys Pro Val Ala Arg Lys Gly Gln Val Asp Leu Lys Lys 
        115                 120                 125             


Ser Arg Leu Arg Met Ser Leu Gln Glu Lys Leu Leu Thr Tyr Tyr Arg 
    130                 135                 140                 


Asn Arg Ala Ala Ile Pro Ala Gly Glu Gln Ala Arg Ala Lys Gln Ala 
145                 150                 155                 160 


Ala Val Asp Ile Cys Ala Glu Leu Arg Ser Phe Leu Arg Ala Lys Leu 
                165                 170                 175     


Pro Asp Met Pro Leu Arg Asp Met Tyr Leu Ser Gly Ser Leu Tyr Asp 
            180                 185                 190         


Asp Leu Gln Val Val Thr Ala Asp His Ile Gln Leu Ile Val Pro Leu 
        195                 200                 205             


Val Leu Glu Gln Asn Leu Trp Ser Cys Ile Pro Gly Glu Asp Thr Ile 
    210                 215                 220                 


Met Asn Val Pro Gly Phe Phe Leu Val Arg Arg Glu Asn Pro Glu Tyr 
225                 230                 235                 240 


Phe Pro Arg Gly Ser Ser Tyr Trp Asp Arg Cys Val Val Gly Gly Tyr 
                245                 250                 255     


Leu Ser Pro Lys Thr Val Ala Asp Thr Phe Glu Lys Val Val Ala Gly 
            260                 265                 270         


Ser Ile Asn Trp Pro Ala Ile Gly Ser Leu Leu Asp Tyr Val Ile Arg 
        275                 280                 285             


Pro Ala Pro Pro Pro Glu Ala Leu Thr Leu Glu Val Gln Tyr Glu Arg 
    290                 295                 300                 


Asp Lys His Leu Phe Ile Asp Phe Leu Pro Ser Val Thr Leu Gly Asp 
305                 310                 315                 320 


Thr Val Leu Val Ala Lys Pro His Arg Leu Ala Gln Tyr Asp Asn Leu 
                325                 330                 335     


Trp Arg Leu Ser Leu Arg Pro Ala Glu Thr Ala Arg Leu Arg Ala Leu 
            340                 345                 350         


Asp Gln Ala Asp Ser Gly Cys Arg Ser Leu Cys Leu Lys Ile Leu Lys 
        355                 360                 365             


Ala Ile Cys Lys Ser Thr Pro Ala Leu Gly His Leu Thr Ala Ser Gln 
    370                 375                 380                 


Leu Thr Asn Val Ile Leu His Leu Ala Gln Glu Glu Ala Asp Trp Ser 
385                 390                 395                 400 


Pro Asp Met Leu Ala Asp Arg Phe Leu Gln Ala Leu Arg Gly Leu Ile 
                405                 410                 415     


Ser Tyr Leu Glu Ala Gly Val Leu Pro Ser Ala Leu Asn Pro Lys Val 
            420                 425                 430         


Asn Leu Phe Ala Glu Leu Thr Pro Glu Glu Ile Asp Glu Leu Gly Tyr 
        435                 440                 445             


Thr Leu Tyr Cys Ser Leu Ser Glu Pro Glu Val Leu Leu Gln Thr 
    450                 455                 460             


<210>  791
<211>  7326
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (105)..(6926)

<400>  791
aggacacagc gtccggagcc agaggcgctc ttaacggcgt ttatgtcctt tgctgtctga       60

ggggcctcag ctctgaccaa tctggtcttc gtgtggtcat tagc atg ggc ttc gtg       116
                                                 Met Gly Phe Val          
                                                 1                        

aga cag ata cag ctt ttg ctc tgg aag aac tgg acc ctg cgg aaa agg        164
Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr Leu Arg Lys Arg           
5                   10                  15                  20            

caa aag att cgc ttt gtg gtg gaa ctc gtg tgg cct tta tct tta ttt        212
Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro Leu Ser Leu Phe           
                25                  30                  35                

ctg gtc ttg atc tgg tta agg aat gcc aac ccg ctc tac agc cat cat        260
Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu Tyr Ser His His           
            40                  45                  50                    

gaa tgc cat ttc ccc aac aag gcg atg ccc tca gca gga atg ctg ccg        308
Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala Gly Met Leu Pro           
        55                  60                  65                        

tgg ctc cag ggg atc ttc tgc aat gtg aac aat ccc tgt ttt caa agc        356
Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro Cys Phe Gln Ser           
    70                  75                  80                            

ccc acc cca gga gaa tct cct gga att gtg tca aac tat aac aac tcc        404
Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn Tyr Asn Asn Ser           
85                  90                  95                  100           

atc ttg gca agg gta tat cga gat ttt caa gaa ctc ctc atg aat gca        452
Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu Leu Met Asn Ala           
                105                 110                 115               

cca gag agc cag cac ctt ggc cgt att tgg aca gag cta cac atc ttg        500
Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu Leu His Ile Leu           
            120                 125                 130                   

tcc caa ttc atg gac acc ctc cgg act cac ccg gag aga att gca gga        548
Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu Arg Ile Ala Gly           
        135                 140                 145                       

aga gga ata cga ata agg gat atc ttg aaa gat gaa gaa aca ctg aca        596
Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu Glu Thr Leu Thr           
    150                 155                 160                           

cta ttt ctc att aaa aac atc ggc ctg tct gac tca gtg gtc tac ctt        644
Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser Val Val Tyr Leu           
165                 170                 175                 180           

ctg atc aac tct caa gtc cgt cca gag cag ttc gct cat gga gtc ccg        692
Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala His Gly Val Pro           
                185                 190                 195               

gac ctg gcg ctg aag gac atc gcc tgc agc gag gcc ctc ctg gag cgc        740
Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala Leu Leu Glu Arg           
            200                 205                 210                   

ttc atc atc ttc agc cag aga cgc ggg gca aag acg gtg cgc tat gcc        788
Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr Val Arg Tyr Ala           
        215                 220                 225                       

ctg tgc tcc ctc tcc cag ggc acc cta cag tgg ata gaa gac act ctg        836
Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile Glu Asp Thr Leu           
    230                 235                 240                           

tat gcc aac gtg gac ttc ttc aag ctc ttc cgt gtg ctt ccc aca ctc        884
Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val Leu Pro Thr Leu           
245                 250                 255                 260           

cta gac agc cgt tct caa ggt atc aat ctg aga tct tgg gga gga ata        932
Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser Trp Gly Gly Ile           
                265                 270                 275               

tta tct gat atg tca cca aga att caa gag ttt atc cat cgg ccg agt        980
Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile His Arg Pro Ser           
            280                 285                 290                   

atg cag gac ttg ctg tgg gtg acc agg ccc ctc atg cag aat ggt ggt       1028
Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met Gln Asn Gly Gly           
        295                 300                 305                       

cca gag acc ttt aca aag ctg atg ggc atc ctg tct gac ctc ctg tgt       1076
Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser Asp Leu Leu Cys           
    310                 315                 320                           

ggc tac ccc gag gga ggt ggc tct cgg gtg ctc tcc ttc aac tgg tat       1124
Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser Phe Asn Trp Tyr           
325                 330                 335                 340           

gaa gac aat aac tat aag gcc ttt ctg ggg att gac tcc aca agg aag       1172
Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp Ser Thr Arg Lys           
                345                 350                 355               

gat cct atc tat tct tat gac aga aga aca aca tcc ttt tgt aat gca       1220
Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser Phe Cys Asn Ala           
            360                 365                 370                   

ttg atc cag agc ctg gag tca aat cct tta acc aaa atc gct tgg agg       1268
Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys Ile Ala Trp Arg           
        375                 380                 385                       

gcg gca aag cct ttg ctg atg gga aaa atc ctg tac act cct gat tca       1316
Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr Thr Pro Asp Ser           
    390                 395                 400                           

cct gca gca cga agg ata ctg aag aat gcc aac tca act ttt gaa gaa       1364
Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser Thr Phe Glu Glu           
405                 410                 415                 420           

ctg gaa cac gtt agg aag ttg gtc aaa gcc tgg gaa gaa gta ggg ccc       1412
Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu Glu Val Gly Pro           
                425                 430                 435               

cag atc tgg tac ttc ttt gac aac agc aca cag atg aac atg atc aga       1460
Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met Asn Met Ile Arg           
            440                 445                 450                   

gat acc ctg ggg aac cca aca gta aaa gac ttt ttg aat agg cag ctt       1508
Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu Asn Arg Gln Leu           
        455                 460                 465                       

ggt gaa gaa ggt att act gct gaa gcc atc cta aac ttc ctc tac aag       1556
Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn Phe Leu Tyr Lys           
    470                 475                 480                           

ggc cct cgg gaa agc cag gct gac gac atg gcc aac ttc gac tgg agg       1604
Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn Phe Asp Trp Arg           
485                 490                 495                 500           

gac ata ttt aac atc act gat cgc acc ctc cgc ctg gtc aat caa tac       1652
Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu Val Asn Gln Tyr           
                505                 510                 515               

ctg gag tgc ttg gtc ctg gat aag ttt gaa agc tac aat gat gaa act       1700
Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr Asn Asp Glu Thr           
            520                 525                 530                   

cag ctc acc caa cgt gcc ctc tct cta ctg gag gaa aac atg ttc tgg       1748
Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu Asn Met Phe Trp           
        535                 540                 545                       

gcc gga gtg gta ttc cct gac atg tat ccc tgg acc agc tct cta cca       1796
Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr Ser Ser Leu Pro           
    550                 555                 560                           

ccc cac gtg aag tat aag atc cga atg gac ata gac gtg gtg gag aaa       1844
Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp Val Val Glu Lys           
565                 570                 575                 580           

acc aat aag att aaa gac agg tat tgg gat tct ggt ccc aga gct gat       1892
Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly Pro Arg Ala Asp           
                585                 590                 595               

ccc gtg gaa gat ttc cgg tac atc tgg ggc ggg ttt gcc tat ctg cag       1940
Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe Ala Tyr Leu Gln           
            600                 605                 610                   

gac atg gtt gaa cag ggg atc aca agg agc cag gtg cag gcg gag gct       1988
Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val Gln Ala Glu Ala           
        615                 620                 625                       

cca gtt gga atc tac ctc cag cag atg ccc tac ccc tgc ttc gtg gac       2036
Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro Cys Phe Val Asp           
    630                 635                 640                           

gat tct ttc atg atc atc ctg aac cgc tgt ttc cct atc ttc atg gtg       2084
Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro Ile Phe Met Val           
645                 650                 655                 660           

ctg gca tgg atc tac tct gtc tcc atg act gtg aag agc atc gtc ttg       2132
Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys Ser Ile Val Leu           
                665                 670                 675               

gag aag gag ttg cga ctg aag gag acc ttg aaa aat cag ggt gtc tcc       2180
Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn Gln Gly Val Ser           
            680                 685                 690                   

aat gca gtg att tgg tgt acc tgg ttc ctg gac agc ttc tcc atc atg       2228
Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser Phe Ser Ile Met           
        695                 700                 705                       

tcg atg agc atc ttc ctc ctg acg ata ttc atc atg cat gga aga atc       2276
Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met His Gly Arg Ile           
    710                 715                 720                           

cta cat tac agc gac cca ttc atc ctc ttc ctg ttc ttg ttg gct ttc       2324
Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe Leu Leu Ala Phe           
725                 730                 735                 740           

tcc act gcc acc atc atg ctg tgc ttt ctg ctc agc acc ttc ttc tcc       2372
Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser Thr Phe Phe Ser           
                745                 750                 755               

aag gcc agt ctg gca gca gcc tgt agt ggt gtc atc tat ttc acc ctc       2420
Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile Tyr Phe Thr Leu           
            760                 765                 770                   

tac ctg cca cac atc ctg tgc ttc gcc tgg cag gac cgc atg acc gct       2468
Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp Arg Met Thr Ala           
        775                 780                 785                       

gag ctg aag aag gct gtg agc tta ctg tct ccg gtg gca ttt gga ttt       2516
Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val Ala Phe Gly Phe           
    790                 795                 800                           

ggc act gag tac ctg gtt cgc ttt gaa gag caa ggc ctg ggg ctg cag       2564
Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly Leu Gly Leu Gln           
805                 810                 815                 820           

tgg agc aac atc ggg aac agt ccc acg gaa ggg gac gaa ttc agc ttc       2612
Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp Glu Phe Ser Phe           
                825                 830                 835               

ctg ctg tcc atg cag atg atg ctc ctt gat gct gct gtc tat ggc tta       2660
Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala Val Tyr Gly Leu           
            840                 845                 850                   

ctc gct tgg tac ctt gat cag gtg ttt cca gga gac tat gga acc cca       2708
Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp Tyr Gly Thr Pro           
        855                 860                 865                       

ctt cct tgg tac ttt ctt cta caa gag tcg tat tgg ctt ggc ggt gaa       2756
Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp Leu Gly Gly Glu           
    870                 875                 880                           

ggg tgt tca acc aga gaa gaa aga gcc ctg gaa aag acc gag ccc cta       2804
Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys Thr Glu Pro Leu           
885                 890                 895                 900           

aca gag gaa acg gag gat cca gag cac cca gaa gga ata cac gac tcc       2852
Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly Ile His Asp Ser           
                905                 910                 915               

ttc ttt gaa cgt gag cat cca ggg tgg gtt cct ggg gta tgc gtg aag       2900
Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly Val Cys Val Lys           
            920                 925                 930                   

aat ctg gta aag att ttt gag ccc tgt ggc cgg cca gct gtg gac cgt       2948
Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro Ala Val Asp Arg           
        935                 940                 945                       

ctg aac atc acc ttc tac gag aac cag atc acc gca ttc ctg ggc cac       2996
Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala Phe Leu Gly His           
    950                 955                 960                           

aat gga gct ggg aaa acc acc acc ttg tcc atc ctg acg ggt ctg ttg       3044
Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu Thr Gly Leu Leu           
965                 970                 975                 980           

cca cca acc tct ggg act gtg ctc gtt ggg gga agg gac att gaa acc       3092
Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg Asp Ile Glu Thr           
                985                 990                 995               

agc ctg gat gca  gtc cgg cag agc ctt  ggc atg tgt cca cag  cac        3137
Ser Leu Asp Ala  Val Arg Gln Ser Leu  Gly Met Cys Pro Gln  His            
            1000                 1005                 1010                

aac atc ctg ttc  cac cac ctc acg gtg  gct gag cac atg ctg  ttc        3182
Asn Ile Leu Phe  His His Leu Thr Val  Ala Glu His Met Leu  Phe            
            1015                 1020                 1025                

tat gcc cag ctg  aaa gga aag tcc cag  gag gag gcc cag ctg  gag        3227
Tyr Ala Gln Leu  Lys Gly Lys Ser Gln  Glu Glu Ala Gln Leu  Glu            
            1030                 1035                 1040                

atg gaa gcc atg  ttg gag gac aca ggc  ctc cac cac aag cgg  aat        3272
Met Glu Ala Met  Leu Glu Asp Thr Gly  Leu His His Lys Arg  Asn            
            1045                 1050                 1055                

gaa gag gct cag  gac cta tca ggt ggc  atg cag aga aag ctg  tcg        3317
Glu Glu Ala Gln  Asp Leu Ser Gly Gly  Met Gln Arg Lys Leu  Ser            
            1060                 1065                 1070                

gtt gcc att gcc  ttt gtg gga gat gcc  aag gtg gtg att ctg  gac        3362
Val Ala Ile Ala  Phe Val Gly Asp Ala  Lys Val Val Ile Leu  Asp            
            1075                 1080                 1085                

gaa ccc acc tct  ggg gtg gac cct tac  tcg aga cgc tca atc  tgg        3407
Glu Pro Thr Ser  Gly Val Asp Pro Tyr  Ser Arg Arg Ser Ile  Trp            
            1090                 1095                 1100                

gat ctg ctc ctg  aag tat cgc tca ggc  aga acc atc atc atg  tcc        3452
Asp Leu Leu Leu  Lys Tyr Arg Ser Gly  Arg Thr Ile Ile Met  Ser            
            1105                 1110                 1115                

act cac cac atg  gac gag gcc gac ctc  ctt ggg gac cgc att  gcc        3497
Thr His His Met  Asp Glu Ala Asp Leu  Leu Gly Asp Arg Ile  Ala            
            1120                 1125                 1130                

atc att gcc cag  gga agg ctc tac tgc  tca ggc acc cca ctc  ttc        3542
Ile Ile Ala Gln  Gly Arg Leu Tyr Cys  Ser Gly Thr Pro Leu  Phe            
            1135                 1140                 1145                

ctg aag aac tgc  ttt ggc aca ggc ttg  tac tta acc ttg gtg  cgc        3587
Leu Lys Asn Cys  Phe Gly Thr Gly Leu  Tyr Leu Thr Leu Val  Arg            
            1150                 1155                 1160                

aag atg aaa aac  atc cag agc caa agg  aaa ggc agt gag ggg  acc        3632
Lys Met Lys Asn  Ile Gln Ser Gln Arg  Lys Gly Ser Glu Gly  Thr            
            1165                 1170                 1175                

tgc agc tgc tcg  tct aag ggt ttc tcc  acc acg tgt cca gcc  cac        3677
Cys Ser Cys Ser  Ser Lys Gly Phe Ser  Thr Thr Cys Pro Ala  His            
            1180                 1185                 1190                

gtc gat gac cta  act cca gaa caa gtc  ctg gat ggg gat gta  aat        3722
Val Asp Asp Leu  Thr Pro Glu Gln Val  Leu Asp Gly Asp Val  Asn            
            1195                 1200                 1205                

gag ctg atg gat  gta gtt ctc cac cat  gtt cca gag gca aag  ctg        3767
Glu Leu Met Asp  Val Val Leu His His  Val Pro Glu Ala Lys  Leu            
            1210                 1215                 1220                

gtg gag tgc att  ggt caa gaa ctt atc  ttc ctt ctt cca aat  aag        3812
Val Glu Cys Ile  Gly Gln Glu Leu Ile  Phe Leu Leu Pro Asn  Lys            
            1225                 1230                 1235                

aac ttc aag cac  aga gca tat gcc agc  ctt ttc aga gag ctg  gag        3857
Asn Phe Lys His  Arg Ala Tyr Ala Ser  Leu Phe Arg Glu Leu  Glu            
            1240                 1245                 1250                

gag acg ctg gct  gac ctt ggt ctc agc  agt ttt gga att tct  gac        3902
Glu Thr Leu Ala  Asp Leu Gly Leu Ser  Ser Phe Gly Ile Ser  Asp            
            1255                 1260                 1265                

act ccc ctg gaa  gag att ttt ctg aag  gtc acg gag gat tct  gat        3947
Thr Pro Leu Glu  Glu Ile Phe Leu Lys  Val Thr Glu Asp Ser  Asp            
            1270                 1275                 1280                

tca gga cct ctg  ttt gcg ggt ggc gct  cag cag aaa aga gaa  aac        3992
Ser Gly Pro Leu  Phe Ala Gly Gly Ala  Gln Gln Lys Arg Glu  Asn            
            1285                 1290                 1295                

gtc aac ccc cga  cac ccc tgc ttg ggt  ccc aga gag aag gct  gga        4037
Val Asn Pro Arg  His Pro Cys Leu Gly  Pro Arg Glu Lys Ala  Gly            
            1300                 1305                 1310                

cag aca ccc cag  gac tcc aat gtc tgc  tcc cca ggg gcg ccg  gct        4082
Gln Thr Pro Gln  Asp Ser Asn Val Cys  Ser Pro Gly Ala Pro  Ala            
            1315                 1320                 1325                

gct cac cca gag  ggc cag cct ccc cca  gag cca gag tgc cca  ggc        4127
Ala His Pro Glu  Gly Gln Pro Pro Pro  Glu Pro Glu Cys Pro  Gly            
            1330                 1335                 1340                

ccg cag ctc aac  acg ggg aca cag ctg  gtc ctc cag cat gtg  cag        4172
Pro Gln Leu Asn  Thr Gly Thr Gln Leu  Val Leu Gln His Val  Gln            
            1345                 1350                 1355                

gcg ctg ctg gtc  aag aga ttc caa cac  acc atc cgc agc cac  aag        4217
Ala Leu Leu Val  Lys Arg Phe Gln His  Thr Ile Arg Ser His  Lys            
            1360                 1365                 1370                

gac ttc ctg gcg  cag atc gtg ctc ccg  gct acc ttt gtg ttt  ttg        4262
Asp Phe Leu Ala  Gln Ile Val Leu Pro  Ala Thr Phe Val Phe  Leu            
            1375                 1380                 1385                

gct ctg atg ctt  tct att gtt atc cct  cct ttt ggc gaa tac  ccc        4307
Ala Leu Met Leu  Ser Ile Val Ile Pro  Pro Phe Gly Glu Tyr  Pro            
            1390                 1395                 1400                

gct ttg acc ctt  cac ccc tgg ata tat  ggg cag cag tac acc  ttc        4352
Ala Leu Thr Leu  His Pro Trp Ile Tyr  Gly Gln Gln Tyr Thr  Phe            
            1405                 1410                 1415                

ttc agc atg gat  gaa cca ggc agt gag  cag ttc acg gta ctt  gca        4397
Phe Ser Met Asp  Glu Pro Gly Ser Glu  Gln Phe Thr Val Leu  Ala            
            1420                 1425                 1430                

gac gtc ctc ctg  aat aag cca ggc ttt  ggc aac cgc tgc ctg  aag        4442
Asp Val Leu Leu  Asn Lys Pro Gly Phe  Gly Asn Arg Cys Leu  Lys            
            1435                 1440                 1445                

gaa ggg tgg ctt  ccg gag tac ccc tgt  ggc aac tca aca ccc  tgg        4487
Glu Gly Trp Leu  Pro Glu Tyr Pro Cys  Gly Asn Ser Thr Pro  Trp            
            1450                 1455                 1460                

aag act cct tct  gtg tcc cca aac atc  acc cag ctg ttc cag  aag        4532
Lys Thr Pro Ser  Val Ser Pro Asn Ile  Thr Gln Leu Phe Gln  Lys            
            1465                 1470                 1475                

cag aaa tgg aca  cag gtc aac cct tca  cca tcc tgc agg tgc  agc        4577
Gln Lys Trp Thr  Gln Val Asn Pro Ser  Pro Ser Cys Arg Cys  Ser            
            1480                 1485                 1490                

acc agg gag aag  ctc acc atg ctg cca  gag tgc ccc gag ggt  gcc        4622
Thr Arg Glu Lys  Leu Thr Met Leu Pro  Glu Cys Pro Glu Gly  Ala            
            1495                 1500                 1505                

ggg ggc ctc ccg  ccc ccc cag aga aca  cag cgc agc acg gaa  att        4667
Gly Gly Leu Pro  Pro Pro Gln Arg Thr  Gln Arg Ser Thr Glu  Ile            
            1510                 1515                 1520                

cta caa gac ctg  acg gac agg aac atc  tcc gac ttc ttg gta  aaa        4712
Leu Gln Asp Leu  Thr Asp Arg Asn Ile  Ser Asp Phe Leu Val  Lys            
            1525                 1530                 1535                

acg tat cct gct  ctt ata aga agc agc  tta aag agc aaa ttc  tgg        4757
Thr Tyr Pro Ala  Leu Ile Arg Ser Ser  Leu Lys Ser Lys Phe  Trp            
            1540                 1545                 1550                

gtc aat gaa cag  agg tat gga gga att  tcc att gga gga aag  ctc        4802
Val Asn Glu Gln  Arg Tyr Gly Gly Ile  Ser Ile Gly Gly Lys  Leu            
            1555                 1560                 1565                

cca gtc gtc ccc  atc acg ggg gaa gca  ctt gtt ggg ttt tta  agc        4847
Pro Val Val Pro  Ile Thr Gly Glu Ala  Leu Val Gly Phe Leu  Ser            
            1570                 1575                 1580                

gac ctt ggc cgg  atc atg aat gtg agc  ggg ggc cct atc act  aga        4892
Asp Leu Gly Arg  Ile Met Asn Val Ser  Gly Gly Pro Ile Thr  Arg            
            1585                 1590                 1595                

gag gcc tct aaa  gaa ata cct gat ttc  ctt aaa cat cta gaa  act        4937
Glu Ala Ser Lys  Glu Ile Pro Asp Phe  Leu Lys His Leu Glu  Thr            
            1600                 1605                 1610                

gaa gac aac att  aag gtg tgg ttt aat  aac aaa ggc tgg cat  gcc        4982
Glu Asp Asn Ile  Lys Val Trp Phe Asn  Asn Lys Gly Trp His  Ala            
            1615                 1620                 1625                

ctg gtc agc ttt  ctc aat gtg gcc cac  aac gcc atc tta cgg  gcc        5027
Leu Val Ser Phe  Leu Asn Val Ala His  Asn Ala Ile Leu Arg  Ala            
            1630                 1635                 1640                

agc ctg cct aag  gac agg agc ccc gag  gag tat gga atc acc  gtc        5072
Ser Leu Pro Lys  Asp Arg Ser Pro Glu  Glu Tyr Gly Ile Thr  Val            
            1645                 1650                 1655                

att agc caa ccc  ctg aac ctg acc aag  gag cag ctc tca gag  att        5117
Ile Ser Gln Pro  Leu Asn Leu Thr Lys  Glu Gln Leu Ser Glu  Ile            
            1660                 1665                 1670                

aca gtg ctg acc  act tca gtg gat gct  gtg gtt gcc atc tgc  gtg        5162
Thr Val Leu Thr  Thr Ser Val Asp Ala  Val Val Ala Ile Cys  Val            
            1675                 1680                 1685                

att ttc tcc atg  tcc ttc gtc cca gcc  agc ttt gtc ctt tat  ttg        5207
Ile Phe Ser Met  Ser Phe Val Pro Ala  Ser Phe Val Leu Tyr  Leu            
            1690                 1695                 1700                

atc cag gag cgg  gtg aac aaa tcc aag  cac ctc cag ttt atc  agt        5252
Ile Gln Glu Arg  Val Asn Lys Ser Lys  His Leu Gln Phe Ile  Ser            
            1705                 1710                 1715                

gga gtg agc ccc  acc acc tac tgg gtg  acc aac ttc ctc tgg  gac        5297
Gly Val Ser Pro  Thr Thr Tyr Trp Val  Thr Asn Phe Leu Trp  Asp            
            1720                 1725                 1730                

atc atg aat tat  tcc gtg agt gct ggg  ctg gtg gtg ggc atc  ttc        5342
Ile Met Asn Tyr  Ser Val Ser Ala Gly  Leu Val Val Gly Ile  Phe            
            1735                 1740                 1745                

atc ggg ttt cag  aag aaa gcc tac act  tct cca gaa aac ctt  cct        5387
Ile Gly Phe Gln  Lys Lys Ala Tyr Thr  Ser Pro Glu Asn Leu  Pro            
            1750                 1755                 1760                

gcc ctt gtg gca  ctg ctc ctg ctg tat  gga tgg gcg gtc att  ccc        5432
Ala Leu Val Ala  Leu Leu Leu Leu Tyr  Gly Trp Ala Val Ile  Pro            
            1765                 1770                 1775                

atg atg tac cca  gca tcc ttc ctg ttt  gat gtc ccc agc aca  gcc        5477
Met Met Tyr Pro  Ala Ser Phe Leu Phe  Asp Val Pro Ser Thr  Ala            
            1780                 1785                 1790                

tat gtg gct tta  tct tgt gct aat ctg  ttc atc ggc atc aac  agc        5522
Tyr Val Ala Leu  Ser Cys Ala Asn Leu  Phe Ile Gly Ile Asn  Ser            
            1795                 1800                 1805                

agt gct att acc  ttc atc ttg gaa tta  ttt gag aat aac cgg  acg        5567
Ser Ala Ile Thr  Phe Ile Leu Glu Leu  Phe Glu Asn Asn Arg  Thr            
            1810                 1815                 1820                

ctg ctc agg ttc  aac gcc gtg ctg agg  aag ctg ctc att gtc  ttc        5612
Leu Leu Arg Phe  Asn Ala Val Leu Arg  Lys Leu Leu Ile Val  Phe            
            1825                 1830                 1835                

ccc cac ttc tgc  ctg ggc cgg ggc ctc  att gac ctt gca ctg  agc        5657
Pro His Phe Cys  Leu Gly Arg Gly Leu  Ile Asp Leu Ala Leu  Ser            
            1840                 1845                 1850                

cag gct gtg aca  gat gtc tat gcc cgg  ttt ggt gag gag cac  tct        5702
Gln Ala Val Thr  Asp Val Tyr Ala Arg  Phe Gly Glu Glu His  Ser            
            1855                 1860                 1865                

gca aat ccg ttc  cac tgg gac ctg att  ggg aag aac ctg ttt  gcc        5747
Ala Asn Pro Phe  His Trp Asp Leu Ile  Gly Lys Asn Leu Phe  Ala            
            1870                 1875                 1880                

atg gtg gtg gaa  ggg gtg gtg tac ttc  ctc ctg acc ctg ctg  gtc        5792
Met Val Val Glu  Gly Val Val Tyr Phe  Leu Leu Thr Leu Leu  Val            
            1885                 1890                 1895                

cag cgc cac ttc  ttc ctc tcc caa tgg  att gcc gag ccc act  aag        5837
Gln Arg His Phe  Phe Leu Ser Gln Trp  Ile Ala Glu Pro Thr  Lys            
            1900                 1905                 1910                

gag ccc att gtt  gat gaa gat gat gat  gtg gct gaa gaa aga  caa        5882
Glu Pro Ile Val  Asp Glu Asp Asp Asp  Val Ala Glu Glu Arg  Gln            
            1915                 1920                 1925                

aga att att act  ggt gga aat aaa act  gac atc tta agg cta  cat        5927
Arg Ile Ile Thr  Gly Gly Asn Lys Thr  Asp Ile Leu Arg Leu  His            
            1930                 1935                 1940                

gaa cta acc aag  att tat cca ggc acc  tcc agc cca gca gtg  gac        5972
Glu Leu Thr Lys  Ile Tyr Pro Gly Thr  Ser Ser Pro Ala Val  Asp            
            1945                 1950                 1955                

agg ctg tgt gtc  gga gtt cgc cct gga  gag tgc ttt ggc ctc  ctg        6017
Arg Leu Cys Val  Gly Val Arg Pro Gly  Glu Cys Phe Gly Leu  Leu            
            1960                 1965                 1970                

gga gtg aat ggt  gcc ggc aaa aca acc  aca ttc aag atg ctc  act        6062
Gly Val Asn Gly  Ala Gly Lys Thr Thr  Thr Phe Lys Met Leu  Thr            
            1975                 1980                 1985                

ggg gac acc aca  gtg acc tca ggg gat  gcc acc gta gca ggc  aag        6107
Gly Asp Thr Thr  Val Thr Ser Gly Asp  Ala Thr Val Ala Gly  Lys            
            1990                 1995                 2000                

agt att tta acc  aat att tct gaa gtc  cat caa aat atg ggc  tac        6152
Ser Ile Leu Thr  Asn Ile Ser Glu Val  His Gln Asn Met Gly  Tyr            
            2005                 2010                 2015                

tgt cct cag ttt  gat gca att gat gag  ctg ctc aca gga cga  gaa        6197
Cys Pro Gln Phe  Asp Ala Ile Asp Glu  Leu Leu Thr Gly Arg  Glu            
            2020                 2025                 2030                

cat ctt tac ctt  tat gcc cgg ctt cga  ggt gta cca gca gaa  gaa        6242
His Leu Tyr Leu  Tyr Ala Arg Leu Arg  Gly Val Pro Ala Glu  Glu            
            2035                 2040                 2045                

atc gaa aag gtt  gca aac tgg agt att  aag agc ctg ggc ctg  act        6287
Ile Glu Lys Val  Ala Asn Trp Ser Ile  Lys Ser Leu Gly Leu  Thr            
            2050                 2055                 2060                

gtc tac gcc gac  tgc ctg gct ggc acg  tac agt ggg ggc aac  aag        6332
Val Tyr Ala Asp  Cys Leu Ala Gly Thr  Tyr Ser Gly Gly Asn  Lys            
            2065                 2070                 2075                

cgg aaa ctc tcc  aca gcc atc gca ctc  att ggc tgc cca ccg  ctg        6377
Arg Lys Leu Ser  Thr Ala Ile Ala Leu  Ile Gly Cys Pro Pro  Leu            
            2080                 2085                 2090                

gtg ctg ctg gat  gag ccc acc aca ggg  atg gac ccc cag gca  cgc        6422
Val Leu Leu Asp  Glu Pro Thr Thr Gly  Met Asp Pro Gln Ala  Arg            
            2095                 2100                 2105                

cgc atg ctg tgg  aac gtc atc gtg agc  atc atc aga gaa ggg  agg        6467
Arg Met Leu Trp  Asn Val Ile Val Ser  Ile Ile Arg Glu Gly  Arg            
            2110                 2115                 2120                

gct gtg gtc ctc  aca tcc cac agc atg  gaa gaa tgt gag gca  ctg        6512
Ala Val Val Leu  Thr Ser His Ser Met  Glu Glu Cys Glu Ala  Leu            
            2125                 2130                 2135                

tgt acc cgg ctg  gcc atc atg gta aag  ggc gcc ttt cga tgt  atg        6557
Cys Thr Arg Leu  Ala Ile Met Val Lys  Gly Ala Phe Arg Cys  Met            
            2140                 2145                 2150                

ggc acc att cag  cat ctc aag tcc aaa  ttt gga gat ggc tat  atc        6602
Gly Thr Ile Gln  His Leu Lys Ser Lys  Phe Gly Asp Gly Tyr  Ile            
            2155                 2160                 2165                

gtc aca atg aag  atc aaa tcc ccg aag  gac gac ctg ctt cct  gac        6647
Val Thr Met Lys  Ile Lys Ser Pro Lys  Asp Asp Leu Leu Pro  Asp            
            2170                 2175                 2180                

ctg aac cct gtg  gag cag ttc ttc cag  ggg aac ttc cca ggc  agt        6692
Leu Asn Pro Val  Glu Gln Phe Phe Gln  Gly Asn Phe Pro Gly  Ser            
            2185                 2190                 2195                

gtg cag agg gag  agg cac tac aac atg  ctc cag ttc cag gtc  tcc        6737
Val Gln Arg Glu  Arg His Tyr Asn Met  Leu Gln Phe Gln Val  Ser            
            2200                 2205                 2210                

tcc tcc tcc ctg  gcg agg atc ttc cag  ctc ctc ctc tcc cac  aag        6782
Ser Ser Ser Leu  Ala Arg Ile Phe Gln  Leu Leu Leu Ser His  Lys            
            2215                 2220                 2225                

gac agc ctg ctc  atc gag gag tac tca  gtc aca cag acc aca  ctg        6827
Asp Ser Leu Leu  Ile Glu Glu Tyr Ser  Val Thr Gln Thr Thr  Leu            
            2230                 2235                 2240                

gac cag gtg ttt  gta aat ttt gct aaa  cag cag act gaa agt  cat        6872
Asp Gln Val Phe  Val Asn Phe Ala Lys  Gln Gln Thr Glu Ser  His            
            2245                 2250                 2255                

gac ctc cct ctg  cac cct cga gct gct  gga gcc agt cga caa  gcc        6917
Asp Leu Pro Leu  His Pro Arg Ala Ala  Gly Ala Ser Arg Gln  Ala            
            2260                 2265                 2270                

cag gac tga tctttcacac cgctcgttcc tgcagccaga aaggaactct               6966
Gln Asp                                                                   
                                                                          

gggcagctgg aggcgcagga gcctgtgccc atatggtcat ccaaatggac tggccagcgt     7026

aaatgacccc actgcagcag aaaacaaaca cacgaggagc atgcagcgaa ttcagaaaga     7086

ggtctttcag aaggaaaccg aaactgactt gctcacctgg aacacctgat ggtgaaacca     7146

aacaaataca aaatccttct ccagacccca gaactagaaa ccccgggcca tcccactagc     7206

agctttggcc tccatattgc tctcatttca agcagatctg cttttctgca tgtttgtctg     7266

tgtgtctgcg ttgtgtgtga ttttcatgga aaaataaaat gcaaatgcac tcatcacaaa     7326


<210>  792
<211>  2273
<212>  PRT
<213>  Homo sapiens

<400>  792

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     


Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         


Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             


His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 


Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 


Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     


Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         


Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             


Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 


Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 


Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     


Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         


Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             


Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 


Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 


Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     


Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         


Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             


Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 


Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 


Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     


Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         


Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             


Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 


Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 


Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 


Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 


Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     


Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         


Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             


Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 


Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 


Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     


Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         


Asp Ile Glu Thr Ser Leu Asp Ala  Val Arg Gln Ser Leu  Gly Met Cys 
        995                 1000                 1005             


Pro Gln  His Asn Ile Leu Phe  His His Leu Thr Val  Ala Glu His 
    1010                 1015                 1020             


Met Leu  Phe Tyr Ala Gln Leu  Lys Gly Lys Ser Gln  Glu Glu Ala 
    1025                 1030                 1035             


Gln Leu  Glu Met Glu Ala Met  Leu Glu Asp Thr Gly  Leu His His 
    1040                 1045                 1050             


Lys Arg  Asn Glu Glu Ala Gln  Asp Leu Ser Gly Gly  Met Gln Arg 
    1055                 1060                 1065             


Lys Leu  Ser Val Ala Ile Ala  Phe Val Gly Asp Ala  Lys Val Val 
    1070                 1075                 1080             


Ile Leu  Asp Glu Pro Thr Ser  Gly Val Asp Pro Tyr  Ser Arg Arg 
    1085                 1090                 1095             


Ser Ile  Trp Asp Leu Leu Leu  Lys Tyr Arg Ser Gly  Arg Thr Ile 
    1100                 1105                 1110             


Ile Met  Ser Thr His His Met  Asp Glu Ala Asp Leu  Leu Gly Asp 
    1115                 1120                 1125             


Arg Ile  Ala Ile Ile Ala Gln  Gly Arg Leu Tyr Cys  Ser Gly Thr 
    1130                 1135                 1140             


Pro Leu  Phe Leu Lys Asn Cys  Phe Gly Thr Gly Leu  Tyr Leu Thr 
    1145                 1150                 1155             


Leu Val  Arg Lys Met Lys Asn  Ile Gln Ser Gln Arg  Lys Gly Ser 
    1160                 1165                 1170             


Glu Gly  Thr Cys Ser Cys Ser  Ser Lys Gly Phe Ser  Thr Thr Cys 
    1175                 1180                 1185             


Pro Ala  His Val Asp Asp Leu  Thr Pro Glu Gln Val  Leu Asp Gly 
    1190                 1195                 1200             


Asp Val  Asn Glu Leu Met Asp  Val Val Leu His His  Val Pro Glu 
    1205                 1210                 1215             


Ala Lys  Leu Val Glu Cys Ile  Gly Gln Glu Leu Ile  Phe Leu Leu 
    1220                 1225                 1230             


Pro Asn  Lys Asn Phe Lys His  Arg Ala Tyr Ala Ser  Leu Phe Arg 
    1235                 1240                 1245             


Glu Leu  Glu Glu Thr Leu Ala  Asp Leu Gly Leu Ser  Ser Phe Gly 
    1250                 1255                 1260             


Ile Ser  Asp Thr Pro Leu Glu  Glu Ile Phe Leu Lys  Val Thr Glu 
    1265                 1270                 1275             


Asp Ser  Asp Ser Gly Pro Leu  Phe Ala Gly Gly Ala  Gln Gln Lys 
    1280                 1285                 1290             


Arg Glu  Asn Val Asn Pro Arg  His Pro Cys Leu Gly  Pro Arg Glu 
    1295                 1300                 1305             


Lys Ala  Gly Gln Thr Pro Gln  Asp Ser Asn Val Cys  Ser Pro Gly 
    1310                 1315                 1320             


Ala Pro  Ala Ala His Pro Glu  Gly Gln Pro Pro Pro  Glu Pro Glu 
    1325                 1330                 1335             


Cys Pro  Gly Pro Gln Leu Asn  Thr Gly Thr Gln Leu  Val Leu Gln 
    1340                 1345                 1350             


His Val  Gln Ala Leu Leu Val  Lys Arg Phe Gln His  Thr Ile Arg 
    1355                 1360                 1365             


Ser His  Lys Asp Phe Leu Ala  Gln Ile Val Leu Pro  Ala Thr Phe 
    1370                 1375                 1380             


Val Phe  Leu Ala Leu Met Leu  Ser Ile Val Ile Pro  Pro Phe Gly 
    1385                 1390                 1395             


Glu Tyr  Pro Ala Leu Thr Leu  His Pro Trp Ile Tyr  Gly Gln Gln 
    1400                 1405                 1410             


Tyr Thr  Phe Phe Ser Met Asp  Glu Pro Gly Ser Glu  Gln Phe Thr 
    1415                 1420                 1425             


Val Leu  Ala Asp Val Leu Leu  Asn Lys Pro Gly Phe  Gly Asn Arg 
    1430                 1435                 1440             


Cys Leu  Lys Glu Gly Trp Leu  Pro Glu Tyr Pro Cys  Gly Asn Ser 
    1445                 1450                 1455             


Thr Pro  Trp Lys Thr Pro Ser  Val Ser Pro Asn Ile  Thr Gln Leu 
    1460                 1465                 1470             


Phe Gln  Lys Gln Lys Trp Thr  Gln Val Asn Pro Ser  Pro Ser Cys 
    1475                 1480                 1485             


Arg Cys  Ser Thr Arg Glu Lys  Leu Thr Met Leu Pro  Glu Cys Pro 
    1490                 1495                 1500             


Glu Gly  Ala Gly Gly Leu Pro  Pro Pro Gln Arg Thr  Gln Arg Ser 
    1505                 1510                 1515             


Thr Glu  Ile Leu Gln Asp Leu  Thr Asp Arg Asn Ile  Ser Asp Phe 
    1520                 1525                 1530             


Leu Val  Lys Thr Tyr Pro Ala  Leu Ile Arg Ser Ser  Leu Lys Ser 
    1535                 1540                 1545             


Lys Phe  Trp Val Asn Glu Gln  Arg Tyr Gly Gly Ile  Ser Ile Gly 
    1550                 1555                 1560             


Gly Lys  Leu Pro Val Val Pro  Ile Thr Gly Glu Ala  Leu Val Gly 
    1565                 1570                 1575             


Phe Leu  Ser Asp Leu Gly Arg  Ile Met Asn Val Ser  Gly Gly Pro 
    1580                 1585                 1590             


Ile Thr  Arg Glu Ala Ser Lys  Glu Ile Pro Asp Phe  Leu Lys His 
    1595                 1600                 1605             


Leu Glu  Thr Glu Asp Asn Ile  Lys Val Trp Phe Asn  Asn Lys Gly 
    1610                 1615                 1620             


Trp His  Ala Leu Val Ser Phe  Leu Asn Val Ala His  Asn Ala Ile 
    1625                 1630                 1635             


Leu Arg  Ala Ser Leu Pro Lys  Asp Arg Ser Pro Glu  Glu Tyr Gly 
    1640                 1645                 1650             


Ile Thr  Val Ile Ser Gln Pro  Leu Asn Leu Thr Lys  Glu Gln Leu 
    1655                 1660                 1665             


Ser Glu  Ile Thr Val Leu Thr  Thr Ser Val Asp Ala  Val Val Ala 
    1670                 1675                 1680             


Ile Cys  Val Ile Phe Ser Met  Ser Phe Val Pro Ala  Ser Phe Val 
    1685                 1690                 1695             


Leu Tyr  Leu Ile Gln Glu Arg  Val Asn Lys Ser Lys  His Leu Gln 
    1700                 1705                 1710             


Phe Ile  Ser Gly Val Ser Pro  Thr Thr Tyr Trp Val  Thr Asn Phe 
    1715                 1720                 1725             


Leu Trp  Asp Ile Met Asn Tyr  Ser Val Ser Ala Gly  Leu Val Val 
    1730                 1735                 1740             


Gly Ile  Phe Ile Gly Phe Gln  Lys Lys Ala Tyr Thr  Ser Pro Glu 
    1745                 1750                 1755             


Asn Leu  Pro Ala Leu Val Ala  Leu Leu Leu Leu Tyr  Gly Trp Ala 
    1760                 1765                 1770             


Val Ile  Pro Met Met Tyr Pro  Ala Ser Phe Leu Phe  Asp Val Pro 
    1775                 1780                 1785             


Ser Thr  Ala Tyr Val Ala Leu  Ser Cys Ala Asn Leu  Phe Ile Gly 
    1790                 1795                 1800             


Ile Asn  Ser Ser Ala Ile Thr  Phe Ile Leu Glu Leu  Phe Glu Asn 
    1805                 1810                 1815             


Asn Arg  Thr Leu Leu Arg Phe  Asn Ala Val Leu Arg  Lys Leu Leu 
    1820                 1825                 1830             


Ile Val  Phe Pro His Phe Cys  Leu Gly Arg Gly Leu  Ile Asp Leu 
    1835                 1840                 1845             


Ala Leu  Ser Gln Ala Val Thr  Asp Val Tyr Ala Arg  Phe Gly Glu 
    1850                 1855                 1860             


Glu His  Ser Ala Asn Pro Phe  His Trp Asp Leu Ile  Gly Lys Asn 
    1865                 1870                 1875             


Leu Phe  Ala Met Val Val Glu  Gly Val Val Tyr Phe  Leu Leu Thr 
    1880                 1885                 1890             


Leu Leu  Val Gln Arg His Phe  Phe Leu Ser Gln Trp  Ile Ala Glu 
    1895                 1900                 1905             


Pro Thr  Lys Glu Pro Ile Val  Asp Glu Asp Asp Asp  Val Ala Glu 
    1910                 1915                 1920             


Glu Arg  Gln Arg Ile Ile Thr  Gly Gly Asn Lys Thr  Asp Ile Leu 
    1925                 1930                 1935             


Arg Leu  His Glu Leu Thr Lys  Ile Tyr Pro Gly Thr  Ser Ser Pro 
    1940                 1945                 1950             


Ala Val  Asp Arg Leu Cys Val  Gly Val Arg Pro Gly  Glu Cys Phe 
    1955                 1960                 1965             


Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys Thr Thr  Thr Phe Lys 
    1970                 1975                 1980             


Met Leu  Thr Gly Asp Thr Thr  Val Thr Ser Gly Asp  Ala Thr Val 
    1985                 1990                 1995             


Ala Gly  Lys Ser Ile Leu Thr  Asn Ile Ser Glu Val  His Gln Asn 
    2000                 2005                 2010             


Met Gly  Tyr Cys Pro Gln Phe  Asp Ala Ile Asp Glu  Leu Leu Thr 
    2015                 2020                 2025             


Gly Arg  Glu His Leu Tyr Leu  Tyr Ala Arg Leu Arg  Gly Val Pro 
    2030                 2035                 2040             


Ala Glu  Glu Ile Glu Lys Val  Ala Asn Trp Ser Ile  Lys Ser Leu 
    2045                 2050                 2055             


Gly Leu  Thr Val Tyr Ala Asp  Cys Leu Ala Gly Thr  Tyr Ser Gly 
    2060                 2065                 2070             


Gly Asn  Lys Arg Lys Leu Ser  Thr Ala Ile Ala Leu  Ile Gly Cys 
    2075                 2080                 2085             


Pro Pro  Leu Val Leu Leu Asp  Glu Pro Thr Thr Gly  Met Asp Pro 
    2090                 2095                 2100             


Gln Ala  Arg Arg Met Leu Trp  Asn Val Ile Val Ser  Ile Ile Arg 
    2105                 2110                 2115             


Glu Gly  Arg Ala Val Val Leu  Thr Ser His Ser Met  Glu Glu Cys 
    2120                 2125                 2130             


Glu Ala  Leu Cys Thr Arg Leu  Ala Ile Met Val Lys  Gly Ala Phe 
    2135                 2140                 2145             


Arg Cys  Met Gly Thr Ile Gln  His Leu Lys Ser Lys  Phe Gly Asp 
    2150                 2155                 2160             


Gly Tyr  Ile Val Thr Met Lys  Ile Lys Ser Pro Lys  Asp Asp Leu 
    2165                 2170                 2175             


Leu Pro  Asp Leu Asn Pro Val  Glu Gln Phe Phe Gln  Gly Asn Phe 
    2180                 2185                 2190             


Pro Gly  Ser Val Gln Arg Glu  Arg His Tyr Asn Met  Leu Gln Phe 
    2195                 2200                 2205             


Gln Val  Ser Ser Ser Ser Leu  Ala Arg Ile Phe Gln  Leu Leu Leu 
    2210                 2215                 2220             


Ser His  Lys Asp Ser Leu Leu  Ile Glu Glu Tyr Ser  Val Thr Gln 
    2225                 2230                 2235             


Thr Thr  Leu Asp Gln Val Phe  Val Asn Phe Ala Lys  Gln Gln Thr 
    2240                 2245                 2250             


Glu Ser  His Asp Leu Pro Leu  His Pro Arg Ala Ala  Gly Ala Ser 
    2255                 2260                 2265             


Arg Gln  Ala Gln Asp 
    2270             


<210>  793
<211>  2989
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (927)..(2651)

<400>  793
gtctgggccg agcccgccca gctggctgag acgcgtggag cctggcggcg agtgggggcg       60

tgcgacggtt actctggtta ctggggccgc gccgcgctgg cgagagccgc cgcccgcgag      120

ggatgctggt gaggaagccg tcgggagccg ccgccgccat ctgagggagg taccctggaa      180

accacctttt atcggtgggg aagtgcagtc gcggtgggcg gctctggggg ccagcgaaac      240

gggaggcctc taaatcttta ggttggggct gcattgccct ggagccgcac tcttgagtcc      300

gaggccatct tttgttggag aaggcgtcgg cgttggcgtt ttcccgaggt tgggctgtac      360

agtgtctccg tccgcggaaa aagaagcctc tgaacccgcg ccggcccgca gcccccgtgc      420

cttccggccg ctgctcgccg tcgccagagg ctaggccacg tttcccccag tgccgaggtg      480

tttctgtgac cctccctcca ctcccattcc cttctgaaag ggcacctgct cttggtgaga      540

aaagaaatta tagcacgaag agccagtatc agaagagtat ccatcacccg cagcaaccgc      600

tcagggaaca ccatcaaaaa agaaaaaaag ggaatatctg gatttcctgg gcgaggagga      660

gcgagtctgc tcgggagctg ttccagcagg cgatttttaa atactgcttt ctacgcccta      720

tacaacttgg cttcacatac ttttacacta actttatatg atttttaaaa actggtctga      780

tcggacttct cgtcctggga cactgtttac tggagtctgg ccggctctcc gtgctcctct      840

tggtacctca ttttggggag aaccttaaac ccactcgagc agataatctc cgccttgacc      900

ggtgccacca aagaagcctt ggaacc atg tgg act ttt ctg ggc att gcc act       953
                             Met Trp Thr Phe Leu Gly Ile Ala Thr          
                             1               5                            

ttc acc tat ttt tat aag aag ttc ggg gac ttc atc act ttg gcc aac       1001
Phe Thr Tyr Phe Tyr Lys Lys Phe Gly Asp Phe Ile Thr Leu Ala Asn           
10                  15                  20                  25            

agg gag gtc ctg ttg tgc gtg ctg gtg ttc ctc tcg ctg ggc ctg gtg       1049
Arg Glu Val Leu Leu Cys Val Leu Val Phe Leu Ser Leu Gly Leu Val           
                30                  35                  40                

ctc tcc tac cgc tgt cgc cac cga aac ggg ggt ctc ctc ggg cgc cag       1097
Leu Ser Tyr Arg Cys Arg His Arg Asn Gly Gly Leu Leu Gly Arg Gln           
            45                  50                  55                    

cag agc ggc tcc cag ttc gcc ctc ttc tcg gat att ctc tca ggc ctg       1145
Gln Ser Gly Ser Gln Phe Ala Leu Phe Ser Asp Ile Leu Ser Gly Leu           
        60                  65                  70                        

cct ttc att ggc ttc ttc tgg gcc aaa tcc ccc cct gaa tca gaa aat       1193
Pro Phe Ile Gly Phe Phe Trp Ala Lys Ser Pro Pro Glu Ser Glu Asn           
    75                  80                  85                            

aag gag cag ctc gag gcc agg agg cgc aga aaa gga acc aat att tca       1241
Lys Glu Gln Leu Glu Ala Arg Arg Arg Arg Lys Gly Thr Asn Ile Ser           
90                  95                  100                 105           

gaa aca agc tta ata gga aca gct gcc tgt aca tca aca tct tct cag       1289
Glu Thr Ser Leu Ile Gly Thr Ala Ala Cys Thr Ser Thr Ser Ser Gln           
                110                 115                 120               

aat gac cca gaa gtt atc atc gtg gga gct ggc gtg ctt ggc tct gct       1337
Asn Asp Pro Glu Val Ile Ile Val Gly Ala Gly Val Leu Gly Ser Ala           
            125                 130                 135                   

ttg gca gct gtg ctt tcc aga gat gga aga aag gtg aca gtc att gag       1385
Leu Ala Ala Val Leu Ser Arg Asp Gly Arg Lys Val Thr Val Ile Glu           
        140                 145                 150                       

aga gac tta aaa gag cct gac aga ata gtt gga gaa ttc ctg cag ccg       1433
Arg Asp Leu Lys Glu Pro Asp Arg Ile Val Gly Glu Phe Leu Gln Pro           
    155                 160                 165                           

ggt ggt tat cat gtt ctc aaa gac ctt ggt ctt gga gat aca gtg gaa       1481
Gly Gly Tyr His Val Leu Lys Asp Leu Gly Leu Gly Asp Thr Val Glu           
170                 175                 180                 185           

ggt ctt gat gcc cag gtt gta aat ggt tac atg att cat gat cag gaa       1529
Gly Leu Asp Ala Gln Val Val Asn Gly Tyr Met Ile His Asp Gln Glu           
                190                 195                 200               

agc aaa tca gag gtt cag att cct tac cct ctg tca gaa aac aat caa       1577
Ser Lys Ser Glu Val Gln Ile Pro Tyr Pro Leu Ser Glu Asn Asn Gln           
            205                 210                 215                   

gtg cag agt gga aga gct ttc cat cac gga aga ttc atc atg agt ctc       1625
Val Gln Ser Gly Arg Ala Phe His His Gly Arg Phe Ile Met Ser Leu           
        220                 225                 230                       

cgg aaa gca gct atg gca gag ccc aat gca aag ttt att gaa ggt gtt       1673
Arg Lys Ala Ala Met Ala Glu Pro Asn Ala Lys Phe Ile Glu Gly Val           
    235                 240                 245                           

gtg tta cag tta tta gag gaa gat gat gtt gtg atg gga gtt cag tac       1721
Val Leu Gln Leu Leu Glu Glu Asp Asp Val Val Met Gly Val Gln Tyr           
250                 255                 260                 265           

aag gat aaa gag act gga gat atc aag gaa ctc cat gct cca ctg act       1769
Lys Asp Lys Glu Thr Gly Asp Ile Lys Glu Leu His Ala Pro Leu Thr           
                270                 275                 280               

gtt gtt gca gat ggg ctt ttc tcc aag ttc agg aaa agc ctg gtc tcc       1817
Val Val Ala Asp Gly Leu Phe Ser Lys Phe Arg Lys Ser Leu Val Ser           
            285                 290                 295                   

aat aaa gtt tct gta tca tct cat ttt gtt ggc ttt ctt atg aag aat       1865
Asn Lys Val Ser Val Ser Ser His Phe Val Gly Phe Leu Met Lys Asn           
        300                 305                 310                       

gca cca cag ttt aaa gca aat cat gct gaa ctt att tta gct aac ccg       1913
Ala Pro Gln Phe Lys Ala Asn His Ala Glu Leu Ile Leu Ala Asn Pro           
    315                 320                 325                           

agt cca gtt ctc atc tac cag att tca tcc agt gaa act cga gta ctt       1961
Ser Pro Val Leu Ile Tyr Gln Ile Ser Ser Ser Glu Thr Arg Val Leu           
330                 335                 340                 345           

gtt gac att aga gga gaa atg cca agg aat tta aga gaa tac atg gtt       2009
Val Asp Ile Arg Gly Glu Met Pro Arg Asn Leu Arg Glu Tyr Met Val           
                350                 355                 360               

gaa aaa att tac cca caa ata cct gat cac ctg aaa gaa cca ttc tta       2057
Glu Lys Ile Tyr Pro Gln Ile Pro Asp His Leu Lys Glu Pro Phe Leu           
            365                 370                 375                   

gaa gcc act gac aat tct cat ctg agg tcc atg cca gca agc ttc ctt       2105
Glu Ala Thr Asp Asn Ser His Leu Arg Ser Met Pro Ala Ser Phe Leu           
        380                 385                 390                       

cct cct tca tca gtg aag aaa cga ggt gtt ctt ctt ttg gga gac gca       2153
Pro Pro Ser Ser Val Lys Lys Arg Gly Val Leu Leu Leu Gly Asp Ala           
    395                 400                 405                           

tat aat atg agg cat cca ctt act ggt gga gga atg act gtt gct ttt       2201
Tyr Asn Met Arg His Pro Leu Thr Gly Gly Gly Met Thr Val Ala Phe           
410                 415                 420                 425           

aaa gat ata aaa cta tgg aga aaa ctg cta aag ggt atc cct gac ctt       2249
Lys Asp Ile Lys Leu Trp Arg Lys Leu Leu Lys Gly Ile Pro Asp Leu           
                430                 435                 440               

tat gat gat gca gct att ttc gag gcc aaa aaa tca ttt tac tgg gca       2297
Tyr Asp Asp Ala Ala Ile Phe Glu Ala Lys Lys Ser Phe Tyr Trp Ala           
            445                 450                 455                   

aga aaa aca tct cat tcc ttt gtc gtg aat atc ctt gct cag gct ctt       2345
Arg Lys Thr Ser His Ser Phe Val Val Asn Ile Leu Ala Gln Ala Leu           
        460                 465                 470                       

tat gaa tta ttt tct gcc aca gat gat tcc ctg cat caa cta aga aaa       2393
Tyr Glu Leu Phe Ser Ala Thr Asp Asp Ser Leu His Gln Leu Arg Lys           
    475                 480                 485                           

gcc tgt ttt ctt tat ttc aaa ctt ggt ggc gaa tgt gtt gcg ggt cct       2441
Ala Cys Phe Leu Tyr Phe Lys Leu Gly Gly Glu Cys Val Ala Gly Pro           
490                 495                 500                 505           

gtt ggg ctg ctt tct gta ttg tct cct aac cct cta gtt tta att gga       2489
Val Gly Leu Leu Ser Val Leu Ser Pro Asn Pro Leu Val Leu Ile Gly           
                510                 515                 520               

cac ttc ttt gct gtt gca atc tat gcc gtg tat ttt tgc ttt aag tca       2537
His Phe Phe Ala Val Ala Ile Tyr Ala Val Tyr Phe Cys Phe Lys Ser           
            525                 530                 535                   

gaa cct tgg att aca aaa cct cga gcc ctt ctc agt agt ggt gct gta       2585
Glu Pro Trp Ile Thr Lys Pro Arg Ala Leu Leu Ser Ser Gly Ala Val           
        540                 545                 550                       

ttg tac aaa gcg tgt tct gta ata ttt cct cta att tac tca gaa atg       2633
Leu Tyr Lys Ala Cys Ser Val Ile Phe Pro Leu Ile Tyr Ser Glu Met           
    555                 560                 565                           

aag tat atg gtt cat taa gcttaaaggg gaaccatttg tgaatgaata              2681
Lys Tyr Met Val His                                                       
570                                                                       

tttggaactt accaagtcct aagagacttt tggaagagga tatatatagc atagtaccat     2741

accacttata aagtggaaac tcttggacca agatttggat taatttgttt ttgaagtttt     2801

ttgtatataa atatgtaaat acatgcttta atttgcaatt taaaatgaag gggttaaata     2861

agttagacat ttaaaagaaa tgattgttac cataaattag tgctaatgct gaggagaact     2921

acagtttttc ttttgaattt agtatttgag atgagttgtt gggacatgca aataaaatga     2981

agaatgaa                                                              2989


<210>  794
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  794

Met Trp Thr Phe Leu Gly Ile Ala Thr Phe Thr Tyr Phe Tyr Lys Lys 
1               5                   10                  15      


Phe Gly Asp Phe Ile Thr Leu Ala Asn Arg Glu Val Leu Leu Cys Val 
            20                  25                  30          


Leu Val Phe Leu Ser Leu Gly Leu Val Leu Ser Tyr Arg Cys Arg His 
        35                  40                  45              


Arg Asn Gly Gly Leu Leu Gly Arg Gln Gln Ser Gly Ser Gln Phe Ala 
    50                  55                  60                  


Leu Phe Ser Asp Ile Leu Ser Gly Leu Pro Phe Ile Gly Phe Phe Trp 
65                  70                  75                  80  


Ala Lys Ser Pro Pro Glu Ser Glu Asn Lys Glu Gln Leu Glu Ala Arg 
                85                  90                  95      


Arg Arg Arg Lys Gly Thr Asn Ile Ser Glu Thr Ser Leu Ile Gly Thr 
            100                 105                 110         


Ala Ala Cys Thr Ser Thr Ser Ser Gln Asn Asp Pro Glu Val Ile Ile 
        115                 120                 125             


Val Gly Ala Gly Val Leu Gly Ser Ala Leu Ala Ala Val Leu Ser Arg 
    130                 135                 140                 


Asp Gly Arg Lys Val Thr Val Ile Glu Arg Asp Leu Lys Glu Pro Asp 
145                 150                 155                 160 


Arg Ile Val Gly Glu Phe Leu Gln Pro Gly Gly Tyr His Val Leu Lys 
                165                 170                 175     


Asp Leu Gly Leu Gly Asp Thr Val Glu Gly Leu Asp Ala Gln Val Val 
            180                 185                 190         


Asn Gly Tyr Met Ile His Asp Gln Glu Ser Lys Ser Glu Val Gln Ile 
        195                 200                 205             


Pro Tyr Pro Leu Ser Glu Asn Asn Gln Val Gln Ser Gly Arg Ala Phe 
    210                 215                 220                 


His His Gly Arg Phe Ile Met Ser Leu Arg Lys Ala Ala Met Ala Glu 
225                 230                 235                 240 


Pro Asn Ala Lys Phe Ile Glu Gly Val Val Leu Gln Leu Leu Glu Glu 
                245                 250                 255     


Asp Asp Val Val Met Gly Val Gln Tyr Lys Asp Lys Glu Thr Gly Asp 
            260                 265                 270         


Ile Lys Glu Leu His Ala Pro Leu Thr Val Val Ala Asp Gly Leu Phe 
        275                 280                 285             


Ser Lys Phe Arg Lys Ser Leu Val Ser Asn Lys Val Ser Val Ser Ser 
    290                 295                 300                 


His Phe Val Gly Phe Leu Met Lys Asn Ala Pro Gln Phe Lys Ala Asn 
305                 310                 315                 320 


His Ala Glu Leu Ile Leu Ala Asn Pro Ser Pro Val Leu Ile Tyr Gln 
                325                 330                 335     


Ile Ser Ser Ser Glu Thr Arg Val Leu Val Asp Ile Arg Gly Glu Met 
            340                 345                 350         


Pro Arg Asn Leu Arg Glu Tyr Met Val Glu Lys Ile Tyr Pro Gln Ile 
        355                 360                 365             


Pro Asp His Leu Lys Glu Pro Phe Leu Glu Ala Thr Asp Asn Ser His 
    370                 375                 380                 


Leu Arg Ser Met Pro Ala Ser Phe Leu Pro Pro Ser Ser Val Lys Lys 
385                 390                 395                 400 


Arg Gly Val Leu Leu Leu Gly Asp Ala Tyr Asn Met Arg His Pro Leu 
                405                 410                 415     


Thr Gly Gly Gly Met Thr Val Ala Phe Lys Asp Ile Lys Leu Trp Arg 
            420                 425                 430         


Lys Leu Leu Lys Gly Ile Pro Asp Leu Tyr Asp Asp Ala Ala Ile Phe 
        435                 440                 445             


Glu Ala Lys Lys Ser Phe Tyr Trp Ala Arg Lys Thr Ser His Ser Phe 
    450                 455                 460                 


Val Val Asn Ile Leu Ala Gln Ala Leu Tyr Glu Leu Phe Ser Ala Thr 
465                 470                 475                 480 


Asp Asp Ser Leu His Gln Leu Arg Lys Ala Cys Phe Leu Tyr Phe Lys 
                485                 490                 495     


Leu Gly Gly Glu Cys Val Ala Gly Pro Val Gly Leu Leu Ser Val Leu 
            500                 505                 510         


Ser Pro Asn Pro Leu Val Leu Ile Gly His Phe Phe Ala Val Ala Ile 
        515                 520                 525             


Tyr Ala Val Tyr Phe Cys Phe Lys Ser Glu Pro Trp Ile Thr Lys Pro 
    530                 535                 540                 


Arg Ala Leu Leu Ser Ser Gly Ala Val Leu Tyr Lys Ala Cys Ser Val 
545                 550                 555                 560 


Ile Phe Pro Leu Ile Tyr Ser Glu Met Lys Tyr Met Val His 
                565                 570                 


<210>  795
<211>  5845
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1263)..(2423)

<400>  795
ggtctgaggg agcggggcgg tctccgccgg cgtcgcgcgc gctgtgtgtg agcggggtcg       60

cgcgcgcgcg cggcaggcga gtgagggaac gaggagcggc cgggtgtgag tgtgtgggag      120

tgagagtgtg tgggagtggg gtgagggaga agctgacggg acgcgaggct gtgagaaact      180

gggcgagtgt gcgaggacgc ccggccagcc tgcgggagcc gcagtcggcg gaggagaaag      240

gaggcggctc ccggtatccc gaccccctcc ccctcctctc cttcccccac ttccagccgc      300

ccggcggccc gcgcttcctc gaaggcccca gcccggctca gtcggccgag agcgagggag      360

gagccccccg acccaggtgc tggagtctgc ttgtcaggga ggggggcagt ctgtgattct      420

gagaacagag ccaagaaggg gaacagcaaa ttcagtcaca gacaatcctc cactcggtca      480

agagccactt ttctcttcct gccttgcccc cccgcagggg gtaaggaact gagcgtttaa      540

tctttagccg gttggctacc agctaaaatt ctacttatct tagtttctag tggatagctt      600

tcttattttg cccatgtttt cttagaatcc ctgtttaata tacttttgtc agtagtagta      660

tctaggagta gcagggagag tgacaataaa ttagcccctt cttttttccc ttgtcattca      720

ggcccctttt cctctccaga gggaaattac cagtaaactc ttctaaatct tccacccctt      780

ctcagtcata ctgtgaagaa acacactaaa gtggacatta tttgaccagt gaacacgaac      840

ccagcttcag gcattggttt gttgtggcac atggagaaac atctctttta aaatatctcc      900

caattaccct tttcacaatt tgtatccacc taggatttgc tgctggggta agtcactaga      960

tttatttctc aaagctcccc tctctatgag ctgaaagact gaccaaccat gaacactagt     1020

aggggatggg gaaaggggac agagcagagc cagttgttcc acactttggg aagcaggagt     1080

agcttttatc atcttcctct ggggagcagg catagagaca taaactgagt gaaaatgggt     1140

ggaggaagaa cttctatacc cacgaacaac atgtgaagag agagaaccaa acataaagta     1200

aggagggtag acgttacatc caagaggaaa taatccaggc aaggaagcac aagctgatca     1260

ag atg tgt agt tct gtg gct gcc aag ttg tgg ttt ttg aca gat cgt        1307
   Met Cys Ser Ser Val Ala Ala Lys Leu Trp Phe Leu Thr Asp Arg            
   1               5                   10                  15             

cgc atc agg gaa gac tat cct caa aaa gag att tta cga gca ttg aag       1355
Arg Ile Arg Glu Asp Tyr Pro Gln Lys Glu Ile Leu Arg Ala Leu Lys           
                20                  25                  30                

gcc aaa tgt tgt gag gag gaa ctg gac ttt agg gct gtg gtg atg gat       1403
Ala Lys Cys Cys Glu Glu Glu Leu Asp Phe Arg Ala Val Val Met Asp           
            35                  40                  45                    

gag gtg gtg ctg aca atc gag caa gga aac ctg ggt ctg cgg atc aat       1451
Glu Val Val Leu Thr Ile Glu Gln Gly Asn Leu Gly Leu Arg Ile Asn           
        50                  55                  60                        

gga gag cta atc act gcc tac cca caa gtg gtg gta gtc aga gta cca       1499
Gly Glu Leu Ile Thr Ala Tyr Pro Gln Val Val Val Val Arg Val Pro           
    65                  70                  75                            

acc cct tgg gtg caa agt gat agt gac atc act gtt ttg cgc cat cta       1547
Thr Pro Trp Val Gln Ser Asp Ser Asp Ile Thr Val Leu Arg His Leu           
80                  85                  90                  95            

gag aag atg gga tgt cgg tta atg aac cga cct caa gcc atc ctg aac       1595
Glu Lys Met Gly Cys Arg Leu Met Asn Arg Pro Gln Ala Ile Leu Asn           
                100                 105                 110               

tgc gtt aat aag ttc tgg aca ttt caa gag ttg gct ggc cat ggt gtt       1643
Cys Val Asn Lys Phe Trp Thr Phe Gln Glu Leu Ala Gly His Gly Val           
            115                 120                 125                   

cct ctg ccg gat act ttc tct tat ggt ggc cac gaa aat ttt gct aaa       1691
Pro Leu Pro Asp Thr Phe Ser Tyr Gly Gly His Glu Asn Phe Ala Lys           
        130                 135                 140                       

atg att gat gag gct gaa gtt ctg gag ttc cca atg gta gta aag aat       1739
Met Ile Asp Glu Ala Glu Val Leu Glu Phe Pro Met Val Val Lys Asn           
    145                 150                 155                           

acg cgg ggt cac aga ggt aaa gct gtt ttc ttg gct cga gat aag cac       1787
Thr Arg Gly His Arg Gly Lys Ala Val Phe Leu Ala Arg Asp Lys His           
160                 165                 170                 175           

cat ttg gct gat cta agc cat ctt att cgc cat gaa gcg cca tac ctg       1835
His Leu Ala Asp Leu Ser His Leu Ile Arg His Glu Ala Pro Tyr Leu           
                180                 185                 190               

ttc cag aag tat gtt aaa gag tct cat gga cgg gat gta cgt gtc att       1883
Phe Gln Lys Tyr Val Lys Glu Ser His Gly Arg Asp Val Arg Val Ile           
            195                 200                 205                   

gtc gtg gga ggc cgt gtg gtt ggc acc atg tta cgt tgt tca aca gat       1931
Val Val Gly Gly Arg Val Val Gly Thr Met Leu Arg Cys Ser Thr Asp           
        210                 215                 220                       

ggg aga atg caa agc aac tgc tca tta ggt ggt gtg ggg atg atg tgc       1979
Gly Arg Met Gln Ser Asn Cys Ser Leu Gly Gly Val Gly Met Met Cys           
    225                 230                 235                           

tca ttg agt gaa caa ggg aag cag cta gct atc cag gtg tct aat atc       2027
Ser Leu Ser Glu Gln Gly Lys Gln Leu Ala Ile Gln Val Ser Asn Ile           
240                 245                 250                 255           

ctg ggg atg gat gtg tgt ggc att gac ctg ctg atg aaa gat gac ggc       2075
Leu Gly Met Asp Val Cys Gly Ile Asp Leu Leu Met Lys Asp Asp Gly           
                260                 265                 270               

tcc ttc tgc gtc tgt gag gcc aat gca aat gta ggt ttc atc gcc ttt       2123
Ser Phe Cys Val Cys Glu Ala Asn Ala Asn Val Gly Phe Ile Ala Phe           
            275                 280                 285                   

gat aag gct tgt aat cta gat gta gct ggt atc ata gca gac tat gcc       2171
Asp Lys Ala Cys Asn Leu Asp Val Ala Gly Ile Ile Ala Asp Tyr Ala           
        290                 295                 300                       

gcc tcc ctt cta ccc tct ggc cgg ctc acc cgg cgt atg tcc ctg ctc       2219
Ala Ser Leu Leu Pro Ser Gly Arg Leu Thr Arg Arg Met Ser Leu Leu           
    305                 310                 315                           

tcc gtg gtg tcc act gcc agt gag act agt gag ccg gag ctg ggt ccc       2267
Ser Val Val Ser Thr Ala Ser Glu Thr Ser Glu Pro Glu Leu Gly Pro           
320                 325                 330                 335           

cca gcc agc act gct gtt gac aac atg agt gca agt tcc agc tct gtt       2315
Pro Ala Ser Thr Ala Val Asp Asn Met Ser Ala Ser Ser Ser Ser Val           
                340                 345                 350               

gac agc gac cct gaa agc acg gag cga gag ctg ctc acc aag ctc cca       2363
Asp Ser Asp Pro Glu Ser Thr Glu Arg Glu Leu Leu Thr Lys Leu Pro           
            355                 360                 365                   

ggg ggc ctg ttc aac atg aac cag ctg cta gcc aat gaa atc aaa cta       2411
Gly Gly Leu Phe Asn Met Asn Gln Leu Leu Ala Asn Glu Ile Lys Leu           
        370                 375                 380                       

ctg gtg gac tga ctccactggt aattaaccaa caaaaccctt gtaaaacttt           2463
Leu Val Asp                                                               
    385                                                                   

ctttcttctt ttctattttt aaaaccaact tgcaatgctg ttcatggagg atgctcagga     2523

agatgagaga aaattagtag gattagttgg agagagtggg agatagatga gacctctgct     2583

agtaagatgt tactttcatt tacaaatcct acaaatagag aggcagaata ggtggggtat     2643

agaaaaatgt caggctctca tagttaccct tttaaattgc taaaaaatgt gtatgctcat     2703

aggccatgag gaacaaatac tttttttttt tcatggtccc ttgcttttgt ttttgtacaa     2763

aaaaaaatgg ttttgctaca aatatccaag tagcataact tcacattgtg ttggaagatt     2823

tgtcatcagt gaggaaaaca tctgcataaa ttacaggaat ttttgtatta tacagctctg     2883

aaaattctgc catttcctta ttaactagca gctttagttt gtagtttatg aaatcttgag     2943

gggctctttt actgggattt cttatttttt tgttttttcc cgcttaattt ggtgggaggt     3003

caaattgaat ataacccaat aaaggcttct taatgacaaa attggcatgt ttgcatgatg     3063

aaatggaaat gaacagtatt gcaatgtccg gtatacaaaa taacattaat tcaatgtaga     3123

taaaattaca ctagtttaaa atatgtgcat tcacttgtat ttgttagtgt tttagtcttt     3183

tttgaaagat gtgctctgtt aatgttgctt tttttttttt ttttaataca tgctagtcta     3243

acatttcctg ctctatgcct gcatctttaa caatggccaa agtgaagaaa atgctacctt     3303

ttttgttaac aagacactga cttgaaacat gtacatttaa agccttttat tttttccctt     3363

tttgttttgg tagttgggca tttaaataag gacaaggaaa aatatttttg ggggcaaatc     3423

aagagcctat gagttctaag tataaagctg aagtgatttc gaatgccagc gttatatatt     3483

tgcatttttc acattttacg agggagtata tgtgtatgtg tgtgcacgca tgcatgtgta     3543

tgtgttttgc tttttgtttc catcaactaa tcaaaaagga taatttagaa aatggagcat     3603

gatgggaaac agagtttttg actttaaaaa acagatgagt tgttttcata agtagactcc     3663

actggggtag aggtattcac cttaaaacat agggtgagta gatgcttttt taggcctttt     3723

tgtgtatatg tacgttgttt gtttttttcc ttttgtttct agcctgttca gtgtacagtt     3783

tattcaaggc tacatgcttt tctttaatgc ttctggctat gcattttctc tttttacata     3843

taggatttgg gattgggggt gggttggatg tttttgtttg gggacttatt tagtagtatt     3903

gagtctctta tagccctact cttaagcctt caatactgtc cactctttat attcctttac     3963

ttgcagaatt tataaaagcc cccaaactgc atataatatg agcctttaaa acatgggtaa     4023

aactaatccc attgatgggt ttggatggta tgttaagaaa tggagatgct gcagagccca     4083

acgtaatttt ttaaacagca agttttccat ctccctacga atcctctgaa gcttttaccc     4143

aagccctttc ttgcctctcc agtgctattt tccttcagat ggaccttaaa cataatttct     4203

tggacactac tagagagact tcgaggcaat aataaaagat cagtattaac cagctataac     4263

agaggtttga tcatgcttac ttgtacagtt tttcccccgt tttaaaaagg aatgtaataa     4323

aatttgtttt ttccatagaa ttaaataata ttaaaattga gtgaaaggtt gattgttgat     4383

gaatagaata gtacctctca tctgtgcagt gtctcatttc acctcagaga aaaggataca     4443

taagaggagt ttgtaattta tcttaggata ttctaattgc atttaaaaga acttatcttg     4503

cgcagggtaa atgggggact cacatacata tattaatacc tctgactcat taacagaaag     4563

aaatacttgg tacttctttc gctgaatgac catactgtgg aggatgcata ctatttggta     4623

tagagaaata aatgaggaag aaagaactgc ttaattaaat tatcattcat atgttcatat     4683

agagaccatc tggttgccat gtgtattatg acacatacac tttgaatagt tacatatcac     4743

aagtatgtag ttcatgtttg tgttggtggg gtaaggcatc aggaaaaatg tagttagtct     4803

tttcttaact tataccaaat taaccaacta tattatagga aatatgtgaa attagttcat     4863

tagctttatt cactattatg cattcacatg atattaaaac gtacactcac atgttagaat     4923

gaaaagagca gtagttatct tagattttaa aaacatggat atcttcttga attccttcaa     4983

gattgaggta gagaataaga gcaaatcatt ctggaagtac cttaaggaaa caaacagcag     5043

cagatattta ggttaaactt attttcataa ttgtttaata acttttgtat aatcttcatt     5103

gctattatga gagagaatgt atatatcaaa tatgtgtaat gataaaatct gaattgtaaa     5163

atttttgtat attgttaaaa ttgtaattct aaattgtatt tcaaaaatga ttatttctga     5223

tattgttttt atgtcaccca tgatgaaaac tggactttat atatctaaac atacaagtat     5283

gaactattct atttaaaatt tttaatagtt tttttctttt ttggtgccta taattgattg     5343

gtcatttctg ctggcttttc tccaatgaac attgaaatct tcctgtatat gttaccaata     5403

agaaaactac cctggaacag tagaaaaacc caacaagaga cttggcattc atcaagcaca     5463

ttatcagact ttgagaacat attgaaggca ttgactttga aaatcatctc tttttctcaa     5523

gaagaaagca atggagaagc aaatttgttt cattcagtga atccccagtt tggggcttgt     5583

ggggcttaga gacattgtga aatcaaatct tgtgttatac ttttctcctg gctcactttt     5643

tttgagaagg tttatgggct atttggctgg tgagacacga tcccctccta agaaaatgta     5703

ggtgctcaga caggtaacca ctgctgctac tgtttttatt tgtttgtttg ttcaatttta     5763

tttaagattt gtttttgttg tactaggatt ttaaaaaatg taatatattg caggatttat     5823

aaccaggaaa aaaaaaaaaa aa                                              5845


<210>  796
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  796

Met Cys Ser Ser Val Ala Ala Lys Leu Trp Phe Leu Thr Asp Arg Arg 
1               5                   10                  15      


Ile Arg Glu Asp Tyr Pro Gln Lys Glu Ile Leu Arg Ala Leu Lys Ala 
            20                  25                  30          


Lys Cys Cys Glu Glu Glu Leu Asp Phe Arg Ala Val Val Met Asp Glu 
        35                  40                  45              


Val Val Leu Thr Ile Glu Gln Gly Asn Leu Gly Leu Arg Ile Asn Gly 
    50                  55                  60                  


Glu Leu Ile Thr Ala Tyr Pro Gln Val Val Val Val Arg Val Pro Thr 
65                  70                  75                  80  


Pro Trp Val Gln Ser Asp Ser Asp Ile Thr Val Leu Arg His Leu Glu 
                85                  90                  95      


Lys Met Gly Cys Arg Leu Met Asn Arg Pro Gln Ala Ile Leu Asn Cys 
            100                 105                 110         


Val Asn Lys Phe Trp Thr Phe Gln Glu Leu Ala Gly His Gly Val Pro 
        115                 120                 125             


Leu Pro Asp Thr Phe Ser Tyr Gly Gly His Glu Asn Phe Ala Lys Met 
    130                 135                 140                 


Ile Asp Glu Ala Glu Val Leu Glu Phe Pro Met Val Val Lys Asn Thr 
145                 150                 155                 160 


Arg Gly His Arg Gly Lys Ala Val Phe Leu Ala Arg Asp Lys His His 
                165                 170                 175     


Leu Ala Asp Leu Ser His Leu Ile Arg His Glu Ala Pro Tyr Leu Phe 
            180                 185                 190         


Gln Lys Tyr Val Lys Glu Ser His Gly Arg Asp Val Arg Val Ile Val 
        195                 200                 205             


Val Gly Gly Arg Val Val Gly Thr Met Leu Arg Cys Ser Thr Asp Gly 
    210                 215                 220                 


Arg Met Gln Ser Asn Cys Ser Leu Gly Gly Val Gly Met Met Cys Ser 
225                 230                 235                 240 


Leu Ser Glu Gln Gly Lys Gln Leu Ala Ile Gln Val Ser Asn Ile Leu 
                245                 250                 255     


Gly Met Asp Val Cys Gly Ile Asp Leu Leu Met Lys Asp Asp Gly Ser 
            260                 265                 270         


Phe Cys Val Cys Glu Ala Asn Ala Asn Val Gly Phe Ile Ala Phe Asp 
        275                 280                 285             


Lys Ala Cys Asn Leu Asp Val Ala Gly Ile Ile Ala Asp Tyr Ala Ala 
    290                 295                 300                 


Ser Leu Leu Pro Ser Gly Arg Leu Thr Arg Arg Met Ser Leu Leu Ser 
305                 310                 315                 320 


Val Val Ser Thr Ala Ser Glu Thr Ser Glu Pro Glu Leu Gly Pro Pro 
                325                 330                 335     


Ala Ser Thr Ala Val Asp Asn Met Ser Ala Ser Ser Ser Ser Val Asp 
            340                 345                 350         


Ser Asp Pro Glu Ser Thr Glu Arg Glu Leu Leu Thr Lys Leu Pro Gly 
        355                 360                 365             


Gly Leu Phe Asn Met Asn Gln Leu Leu Ala Asn Glu Ile Lys Leu Leu 
    370                 375                 380                 


Val Asp 
385     


<210>  797
<211>  986
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (35)..(538)

<400>  797
aagcaaccca gacttcatac cagctcccaa cacc atg acc tgc tgc cag acc agc       55
                                      Met Thr Cys Cys Gln Thr Ser         
                                      1               5                   

ttc tgt gga tat ccc agc tgc tcc acc agt ggg aca tgc ggc tcc agc        103
Phe Cys Gly Tyr Pro Ser Cys Ser Thr Ser Gly Thr Cys Gly Ser Ser           
        10                  15                  20                        

tgc tgc cag cca agc tgc tgt gag acc agc tgc tgc cag cca agc tgc        151
Cys Cys Gln Pro Ser Cys Cys Glu Thr Ser Cys Cys Gln Pro Ser Cys           
    25                  30                  35                            

tgc cag acc agc ttc tgc gga ttt cct agc ttc tca act agt ggg acc        199
Cys Gln Thr Ser Phe Cys Gly Phe Pro Ser Phe Ser Thr Ser Gly Thr           
40                  45                  50                  55            

tgc agc tcc agt tgc tgc cag cca agc tgc tgt gag acc agc tgc tgc        247
Cys Ser Ser Ser Cys Cys Gln Pro Ser Cys Cys Glu Thr Ser Cys Cys           
                60                  65                  70                

cag cca agc tgc tgc cag acc agc tcc tgc gga act ggc tgt ggc att        295
Gln Pro Ser Cys Cys Gln Thr Ser Ser Cys Gly Thr Gly Cys Gly Ile           
            75                  80                  85                    

ggt ggt ggc att ggc tat ggc cag gag ggc agc agt gga gct gtg agc        343
Gly Gly Gly Ile Gly Tyr Gly Gln Glu Gly Ser Ser Gly Ala Val Ser           
        90                  95                  100                       

acc cgt atc agg tgg tgc cgc cca gac tgc cgt gtg gag ggt acc tgc        391
Thr Arg Ile Arg Trp Cys Arg Pro Asp Cys Arg Val Glu Gly Thr Cys           
    105                 110                 115                           

ctg ccc ccc tgc tgt gtg gtg agc tgc aca ccc cca acc tgc tgc cag        439
Leu Pro Pro Cys Cys Val Val Ser Cys Thr Pro Pro Thr Cys Cys Gln           
120                 125                 130                 135           

ctg cac cac gcc gag gcc tcc tgc tgc cgc cca tcc tac tgt gga cag        487
Leu His His Ala Glu Ala Ser Cys Cys Arg Pro Ser Tyr Cys Gly Gln           
                140                 145                 150               

tcc tgc tgc cgc cca gtc tgc tgc tgc tac tcc tgt gag ccc acc tgc        535
Ser Cys Cys Arg Pro Val Cys Cys Cys Tyr Ser Cys Glu Pro Thr Cys           
            155                 160                 165                   

taa aagccagttt gctgattttc aacttgaaat ttccactttc agttccattc             588

atgaacgaat tatttcttca agcacttatg gacaacgaac aaattcttca acctttcttt      648

gtctttctta tgggggttac caaatatttt ggcctcagaa ttatctgatt cctttcaatt      708

ccagaaagac cttactcttc tctctgagga cgccaaaata caaatttgac ccaagaaatg      768

aaaaagccga tttaccttga aactgagcct ttgcaagcat tgaagcccac gctctgagtc      828

tcagcgccga cgagaccatg gaagagccat ctgtccttct caggacactc acttcctgta      888

tcccaccgtc ctgcaaattg caccccctat gaaagaggaa taatatacca aggtctaata      948

aattttaact attggtgcaa caaaaaaaaa aaaaaaaa                              986


<210>  798
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  798

Met Thr Cys Cys Gln Thr Ser Phe Cys Gly Tyr Pro Ser Cys Ser Thr 
1               5                   10                  15      


Ser Gly Thr Cys Gly Ser Ser Cys Cys Gln Pro Ser Cys Cys Glu Thr 
            20                  25                  30          


Ser Cys Cys Gln Pro Ser Cys Cys Gln Thr Ser Phe Cys Gly Phe Pro 
        35                  40                  45              


Ser Phe Ser Thr Ser Gly Thr Cys Ser Ser Ser Cys Cys Gln Pro Ser 
    50                  55                  60                  


Cys Cys Glu Thr Ser Cys Cys Gln Pro Ser Cys Cys Gln Thr Ser Ser 
65                  70                  75                  80  


Cys Gly Thr Gly Cys Gly Ile Gly Gly Gly Ile Gly Tyr Gly Gln Glu 
                85                  90                  95      


Gly Ser Ser Gly Ala Val Ser Thr Arg Ile Arg Trp Cys Arg Pro Asp 
            100                 105                 110         


Cys Arg Val Glu Gly Thr Cys Leu Pro Pro Cys Cys Val Val Ser Cys 
        115                 120                 125             


Thr Pro Pro Thr Cys Cys Gln Leu His His Ala Glu Ala Ser Cys Cys 
    130                 135                 140                 


Arg Pro Ser Tyr Cys Gly Gln Ser Cys Cys Arg Pro Val Cys Cys Cys 
145                 150                 155                 160 


Tyr Ser Cys Glu Pro Thr Cys 
                165         


<210>  799
<211>  4316
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (40)..(1776)

<400>  799
cgtcatgtta gggtgaagca gaggacctca gtgctgaac atg cta agg agg ttg          54
                                           Met Leu Arg Arg Leu            
                                           1               5              

gac aaa atc agg ttc aga ggt cac aag aga gat gac ttc ctc gat cta        102
Asp Lys Ile Arg Phe Arg Gly His Lys Arg Asp Asp Phe Leu Asp Leu           
                10                  15                  20                

gcg gag tct cca aat gcc tcg gac acc gaa tgc agc gac gaa atc ccc        150
Ala Glu Ser Pro Asn Ala Ser Asp Thr Glu Cys Ser Asp Glu Ile Pro           
            25                  30                  35                    

ctg aag gta ccg cgg acc tcg ccc cgg gac agc gag gag ctg agg gac        198
Leu Lys Val Pro Arg Thr Ser Pro Arg Asp Ser Glu Glu Leu Arg Asp           
        40                  45                  50                        

cct gct ggt cca ggg acc ctc atc atg gcc aca gga gtc cag gac ttt        246
Pro Ala Gly Pro Gly Thr Leu Ile Met Ala Thr Gly Val Gln Asp Phe           
    55                  60                  65                            

aac cgg aca gag ttt gat cga ctg aat gag atc aaa ggt cac ctg gaa        294
Asn Arg Thr Glu Phe Asp Arg Leu Asn Glu Ile Lys Gly His Leu Glu           
70                  75                  80                  85            

att gcc tta ttg gaa aaa cat ttc tta cag gag gag ctc cgg aag ctg        342
Ile Ala Leu Leu Glu Lys His Phe Leu Gln Glu Glu Leu Arg Lys Leu           
                90                  95                  100               

cga gaa gaa acc aac gcg gag atg ctg cgg cag gag ctg gac cgc gag        390
Arg Glu Glu Thr Asn Ala Glu Met Leu Arg Gln Glu Leu Asp Arg Glu           
            105                 110                 115                   

cgg cag cgg cgg atg gag ctg gag cag aag gtg cag gag gtg ctg aag        438
Arg Gln Arg Arg Met Glu Leu Glu Gln Lys Val Gln Glu Val Leu Lys           
        120                 125                 130                       

gcc aga acc gag gag cag atg gct cag cag ccc cca aaa ggg cag gcc        486
Ala Arg Thr Glu Glu Gln Met Ala Gln Gln Pro Pro Lys Gly Gln Ala           
    135                 140                 145                           

cag gcc agc aat gga gca gag cgc cgg agc cag ggg ctg tcc tcg cgc        534
Gln Ala Ser Asn Gly Ala Glu Arg Arg Ser Gln Gly Leu Ser Ser Arg           
150                 155                 160                 165           

ctg cag aag tgg ttc tac gag cgg ttc ggg gag tac gtg gag gac ttc        582
Leu Gln Lys Trp Phe Tyr Glu Arg Phe Gly Glu Tyr Val Glu Asp Phe           
                170                 175                 180               

cgg ttc cag ccc gag gag aac act gtg gag aca gag gaa ccc ctg agc        630
Arg Phe Gln Pro Glu Glu Asn Thr Val Glu Thr Glu Glu Pro Leu Ser           
            185                 190                 195                   

gcc cgc agg tta act gaa aat atg aga cgg ctc aag cgc ggt gcc aag        678
Ala Arg Arg Leu Thr Glu Asn Met Arg Arg Leu Lys Arg Gly Ala Lys           
        200                 205                 210                       

ccg gtc act aac ttt gtg aag aac ctc tct gcc tta tcc gac tgg tac        726
Pro Val Thr Asn Phe Val Lys Asn Leu Ser Ala Leu Ser Asp Trp Tyr           
    215                 220                 225                           

tcc gtc tac acg tct gcc att gcc ttc acc gtg tac atg aat gcc gtg        774
Ser Val Tyr Thr Ser Ala Ile Ala Phe Thr Val Tyr Met Asn Ala Val           
230                 235                 240                 245           

tgg cat ggc tgg gcc atc cca ttg ttc tta ttt cta gca att ctg agg        822
Trp His Gly Trp Ala Ile Pro Leu Phe Leu Phe Leu Ala Ile Leu Arg           
                250                 255                 260               

tta tcc ctc aat tac ctc atc gcc agg ggg tgg cgg ata cag tgg agc        870
Leu Ser Leu Asn Tyr Leu Ile Ala Arg Gly Trp Arg Ile Gln Trp Ser           
            265                 270                 275                   

atc gtg ccc gaa gtg tct gag ccc gtg gaa cct cca aag gaa gac ctg        918
Ile Val Pro Glu Val Ser Glu Pro Val Glu Pro Pro Lys Glu Asp Leu           
        280                 285                 290                       

act gtg tct gag aag ttc cag ctg gtg ctg gac gtc gcc cag aaa gcc        966
Thr Val Ser Glu Lys Phe Gln Leu Val Leu Asp Val Ala Gln Lys Ala           
    295                 300                 305                           

cag aac ctt ttc ggg aag atg gct gac atc ctg gag aag atc aag aac       1014
Gln Asn Leu Phe Gly Lys Met Ala Asp Ile Leu Glu Lys Ile Lys Asn           
310                 315                 320                 325           

ttg ttc atg tgg gtc cag ccg gag atc aca cag aag ctg tat gtg gcg       1062
Leu Phe Met Trp Val Gln Pro Glu Ile Thr Gln Lys Leu Tyr Val Ala           
                330                 335                 340               

ctc tgg gct gcc ttc ctg gcc tcc tgc ttc ttc ccc tac cgc ctg gtg       1110
Leu Trp Ala Ala Phe Leu Ala Ser Cys Phe Phe Pro Tyr Arg Leu Val           
            345                 350                 355                   

ggg ctt gcc gtg gga ctc tat gct ggt atc aag ttc ttc ctc att gat       1158
Gly Leu Ala Val Gly Leu Tyr Ala Gly Ile Lys Phe Phe Leu Ile Asp           
        360                 365                 370                       

ttc atc ttt aaa cgc tgc ccg agg ctg cgc gcc aag tac gac acg ccc       1206
Phe Ile Phe Lys Arg Cys Pro Arg Leu Arg Ala Lys Tyr Asp Thr Pro           
    375                 380                 385                           

tat atc atc tgg agg agt ctc ccc acc gac ccg cag ctc aag gag cgc       1254
Tyr Ile Ile Trp Arg Ser Leu Pro Thr Asp Pro Gln Leu Lys Glu Arg           
390                 395                 400                 405           

tcc agc gcc gca gtc tca cgc agg ctg cag acg acc tcg tca cgg agc       1302
Ser Ser Ala Ala Val Ser Arg Arg Leu Gln Thr Thr Ser Ser Arg Ser           
                410                 415                 420               

tac gta ccc agc gca ccg gcc ggc ctg ggt aaa gag gag gac gcc ggt       1350
Tyr Val Pro Ser Ala Pro Ala Gly Leu Gly Lys Glu Glu Asp Ala Gly           
            425                 430                 435                   

cgc ttc cac agc acc aag aag ggc aat ttc cac gag atc ttc aat ctg       1398
Arg Phe His Ser Thr Lys Lys Gly Asn Phe His Glu Ile Phe Asn Leu           
        440                 445                 450                       

aca gaa aac gag cgt ccg ctg gcg gtg tgc gag aat ggc tgg cgc tgc       1446
Thr Glu Asn Glu Arg Pro Leu Ala Val Cys Glu Asn Gly Trp Arg Cys           
    455                 460                 465                           

tgc ctc atc aac agg gac cgg aag atg ccc acg gac tac atc agg aac       1494
Cys Leu Ile Asn Arg Asp Arg Lys Met Pro Thr Asp Tyr Ile Arg Asn           
470                 475                 480                 485           

ggg gtg ctc tac gtc acg gag aat tac ttg tgc ttc gaa agc tcc aaa       1542
Gly Val Leu Tyr Val Thr Glu Asn Tyr Leu Cys Phe Glu Ser Ser Lys           
                490                 495                 500               

tct ggg tcc tca aag agg aac aaa gtc atc aag cta gtg gac atc acg       1590
Ser Gly Ser Ser Lys Arg Asn Lys Val Ile Lys Leu Val Asp Ile Thr           
            505                 510                 515                   

gac atc cag aag tac aag gtc ctg tct gtc ctc cca ggc tca ggc atg       1638
Asp Ile Gln Lys Tyr Lys Val Leu Ser Val Leu Pro Gly Ser Gly Met           
        520                 525                 530                       

ggg att gcc gtg tcg acg cca tcc acc cag aaa ccg ctc gtg ttt ggt       1686
Gly Ile Ala Val Ser Thr Pro Ser Thr Gln Lys Pro Leu Val Phe Gly           
    535                 540                 545                           

gcc atg gtg cac agg gat gag gcc ttc gag acc att ctc agc cag tac       1734
Ala Met Val His Arg Asp Glu Ala Phe Glu Thr Ile Leu Ser Gln Tyr           
550                 555                 560                 565           

atc aag atc acc tca gcg gca gcg tct ggc ggg gac agc tag               1776
Ile Lys Ile Thr Ser Ala Ala Ala Ser Gly Gly Asp Ser                       
                570                 575                                   

tattgacttg cccaggacgt tgctggaatt ttctttttct ttttcttttt cttttttttt     1836

ttttacgatt tggtagtgga aacaattgga catcctcatg agcttttgca ataattctcc     1896

tggacctgtg gttctattgt gttgacctct gcgttttatc gaccaagaag gggccagggc     1956

tcacagggac gggggtgccc ctctcccaca gggcacgtca ggtgcctctg agggccaccc     2016

gcagactggg ggagggggca gaggccctcg ggggcccgtg gagaagacac acaggacccc     2076

tggccctgcc cttctccgtt ccagcctgga cagagaaacc tctccagcca ccccaagagg     2136

ttctcgcaac cttgtgtccc gctctccaga ggccagaagc tcgtccacca ccaaagccat     2196

agctgaagag tgcggggccc ttcctcctgg ggacagaaag atgtcgtcaa ggagggacat     2256

gggggccttt caccaaccac cgagaaacgg gcctggcggc cctccttcct cttacatgag     2316

accctcctgt ggcatttgcc cttggtgccg ggctggggcc gggcgcagtg accctgcctg     2376

cgctccacac tcgctccacg ggaacagaga gggtgagaag ggcccacccc tcgcctgccc     2436

tcagtgtctt tggtggcacc ttccttgctg gcctccaggg cgctcagcac cgcgtctgta     2496

agggcctgcc tgctgctctc ggcctgacac gccggccagg aggtctgtag ctggggacca     2556

gtaagggcac aggatggtgc aggtaaaagc acatctttct cacactttgc tctttggaag     2616

gcccaggaga acatccgcga aggctgttgg aggtgctccg agcactgtgg catgtctggc     2676

acatggcccc caggctgcgg ttgcctgggt tggttggggg aggaagtggg gaggagtgtt     2736

ccgggaccat ggtggcccag gctgcagccg cctttgggcc atccgagagg ctctggcagc     2796

ccctgtgctt tagggagcaa ccgtgagccg agcccagagg cctgggcctg cactgcctgc     2856

agccgacatg cgacagcgtt ccctcccccg cgtgcctagc cggtgccggt ccgggcacag     2916

acccccccag cccccgccct gccccaggga agcctgggct tcccgggaac aaggtggcat     2976

ttgtggaggg agcgcccgca ggcctggtct gctggggccg cctgcgctgg gctgaaggga     3036

gggaaaggcg gcttgggcct cctggaagga ggtggccacc ccgcgggcct gcgtgtctgc     3096

tggggcggat cccgcagctc cctcagcttg tcctgagtcc cttgggtgtc gttgagattg     3156

ttgttttttg aagaaacaga agattctatt ttttacagcg agcaagctgg ttttcttatt     3216

tttgtatcct ttttcagatg taatttttat ctttgctccg atcctcattt gctggtgtgg     3276

gtgagggatc cggcggcatg ggctggtttc acccccttca cgaggggccg cagagtcaca     3336

cgctggtgcc gggggtgctt tggggggagc tgcgccgatc accagattaa gcacatgtcc     3396

tatcccaggc ggtggagcgg agcccccgtg gctctggact gcgcggacgt tggcgtcagg     3456

atgaccacac ggcggccttt cccgaatggg gacagaaccc gctctgagcc gtgggtctgg     3516

ctcctgtagg ggactggctc tcttggtgca ccaggggagg gggacatatc ccagtgaacc     3576

ccaccttggc gcctgaggca acacagggtg ggcactgacc cacccccagg ggcggctgca     3636

gaggcagtgc ccgcagacaa tggccacacc tctctcccca gggcccggca gtgcccaagg     3696

atgggtccgg ggcctcgggg ccaatgagcg cctcttccta ggtgctggga ttcagtcccc     3756

aaacacagcg ggaggggtcc ctggggcaga tggggcttta ccagcgtcgg gtggtttagt     3816

tcgagtccct tttgtggaga aagggagatg aaaactgacc acgtgccagg tgtggccgaa     3876

gcccccaggg agggccacat tcggggagcg gggggtcggg ggagggccac cgactggctc     3936

tgctgccagc acaggcccct ccctggaagt cctcgggagc ggagcgcgga tcggcacggg     3996

ctctgggctc cccgtggaga gaagctgtag tttttaccaa attgtgtaca tctgggcaga     4056

tgtttaattt ctgtgactaa tcactgaact agacgaatgt taaatttttt atgtctgaag     4116

cctgagtcta ttttggatct gtaaataatc attgccagtg tgacttttgt tcaacaaaag     4176

gattgtactg tattaagaac cgatgaaaaa aattctcctg taacattttt ttaagaaaac     4236

tttgtttgtt taaagaaaaa gtattgtata aattataatt tttatttaaa taaacctaaa     4296

atgctttgtg ctaaggctca                                                 4316


<210>  800
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  800

Met Leu Arg Arg Leu Asp Lys Ile Arg Phe Arg Gly His Lys Arg Asp 
1               5                   10                  15      


Asp Phe Leu Asp Leu Ala Glu Ser Pro Asn Ala Ser Asp Thr Glu Cys 
            20                  25                  30          


Ser Asp Glu Ile Pro Leu Lys Val Pro Arg Thr Ser Pro Arg Asp Ser 
        35                  40                  45              


Glu Glu Leu Arg Asp Pro Ala Gly Pro Gly Thr Leu Ile Met Ala Thr 
    50                  55                  60                  


Gly Val Gln Asp Phe Asn Arg Thr Glu Phe Asp Arg Leu Asn Glu Ile 
65                  70                  75                  80  


Lys Gly His Leu Glu Ile Ala Leu Leu Glu Lys His Phe Leu Gln Glu 
                85                  90                  95      


Glu Leu Arg Lys Leu Arg Glu Glu Thr Asn Ala Glu Met Leu Arg Gln 
            100                 105                 110         


Glu Leu Asp Arg Glu Arg Gln Arg Arg Met Glu Leu Glu Gln Lys Val 
        115                 120                 125             


Gln Glu Val Leu Lys Ala Arg Thr Glu Glu Gln Met Ala Gln Gln Pro 
    130                 135                 140                 


Pro Lys Gly Gln Ala Gln Ala Ser Asn Gly Ala Glu Arg Arg Ser Gln 
145                 150                 155                 160 


Gly Leu Ser Ser Arg Leu Gln Lys Trp Phe Tyr Glu Arg Phe Gly Glu 
                165                 170                 175     


Tyr Val Glu Asp Phe Arg Phe Gln Pro Glu Glu Asn Thr Val Glu Thr 
            180                 185                 190         


Glu Glu Pro Leu Ser Ala Arg Arg Leu Thr Glu Asn Met Arg Arg Leu 
        195                 200                 205             


Lys Arg Gly Ala Lys Pro Val Thr Asn Phe Val Lys Asn Leu Ser Ala 
    210                 215                 220                 


Leu Ser Asp Trp Tyr Ser Val Tyr Thr Ser Ala Ile Ala Phe Thr Val 
225                 230                 235                 240 


Tyr Met Asn Ala Val Trp His Gly Trp Ala Ile Pro Leu Phe Leu Phe 
                245                 250                 255     


Leu Ala Ile Leu Arg Leu Ser Leu Asn Tyr Leu Ile Ala Arg Gly Trp 
            260                 265                 270         


Arg Ile Gln Trp Ser Ile Val Pro Glu Val Ser Glu Pro Val Glu Pro 
        275                 280                 285             


Pro Lys Glu Asp Leu Thr Val Ser Glu Lys Phe Gln Leu Val Leu Asp 
    290                 295                 300                 


Val Ala Gln Lys Ala Gln Asn Leu Phe Gly Lys Met Ala Asp Ile Leu 
305                 310                 315                 320 


Glu Lys Ile Lys Asn Leu Phe Met Trp Val Gln Pro Glu Ile Thr Gln 
                325                 330                 335     


Lys Leu Tyr Val Ala Leu Trp Ala Ala Phe Leu Ala Ser Cys Phe Phe 
            340                 345                 350         


Pro Tyr Arg Leu Val Gly Leu Ala Val Gly Leu Tyr Ala Gly Ile Lys 
        355                 360                 365             


Phe Phe Leu Ile Asp Phe Ile Phe Lys Arg Cys Pro Arg Leu Arg Ala 
    370                 375                 380                 


Lys Tyr Asp Thr Pro Tyr Ile Ile Trp Arg Ser Leu Pro Thr Asp Pro 
385                 390                 395                 400 


Gln Leu Lys Glu Arg Ser Ser Ala Ala Val Ser Arg Arg Leu Gln Thr 
                405                 410                 415     


Thr Ser Ser Arg Ser Tyr Val Pro Ser Ala Pro Ala Gly Leu Gly Lys 
            420                 425                 430         


Glu Glu Asp Ala Gly Arg Phe His Ser Thr Lys Lys Gly Asn Phe His 
        435                 440                 445             


Glu Ile Phe Asn Leu Thr Glu Asn Glu Arg Pro Leu Ala Val Cys Glu 
    450                 455                 460                 


Asn Gly Trp Arg Cys Cys Leu Ile Asn Arg Asp Arg Lys Met Pro Thr 
465                 470                 475                 480 


Asp Tyr Ile Arg Asn Gly Val Leu Tyr Val Thr Glu Asn Tyr Leu Cys 
                485                 490                 495     


Phe Glu Ser Ser Lys Ser Gly Ser Ser Lys Arg Asn Lys Val Ile Lys 
            500                 505                 510         


Leu Val Asp Ile Thr Asp Ile Gln Lys Tyr Lys Val Leu Ser Val Leu 
        515                 520                 525             


Pro Gly Ser Gly Met Gly Ile Ala Val Ser Thr Pro Ser Thr Gln Lys 
    530                 535                 540                 


Pro Leu Val Phe Gly Ala Met Val His Arg Asp Glu Ala Phe Glu Thr 
545                 550                 555                 560 


Ile Leu Ser Gln Tyr Ile Lys Ile Thr Ser Ala Ala Ala Ser Gly Gly 
                565                 570                 575     


Asp Ser 
        


<210>  801
<211>  821
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (63)..(716)

<400>  801
aggatcccaa ggcccaactc cccgaaccac tcagggtcct gtggacagct cacctagcgg       60

ca atg gct gca ggc tcc cgg acg tcc ctg ctc ctg gct ttt ggc ctg         107
   Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu            
   1               5                   10                  15             

ctc tgc ctg tcc tgg ctt caa gag ggc agt gcc ttc cca acc att ccc        155
Leu Cys Leu Ser Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro           
                20                  25                  30                

tta tcc agg ctt ttt gac aac gct atg ctc cgc gcc cgt cgc ctg tac        203
Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala Arg Arg Leu Tyr           
            35                  40                  45                    

cag ctg gca tat gac acc tat cag gag ttt gaa gaa gcc tat atc ctg        251
Gln Leu Ala Tyr Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Leu           
        50                  55                  60                        

aag gag cag aag tat tca ttc ctg cag aac ccc cag acc tcc ctc tgc        299
Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys           
    65                  70                  75                            

ttc tca gag tct att cca aca cct tcc aac agg gtg aaa acg cag cag        347
Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Val Lys Thr Gln Gln           
80                  85                  90                  95            

aaa tct aac cta gag ctg ctc cgc atc tcc ctg ctg ctc atc cag tca        395
Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser           
                100                 105                 110               

tgg ctg gag ccc gtg cag ctc ctc agg agc gtc ttc gcc aac agc ctg        443
Trp Leu Glu Pro Val Gln Leu Leu Arg Ser Val Phe Ala Asn Ser Leu           
            115                 120                 125                   

gtg tat ggc gcc tcg gac agc aac gtc tat cgc cac ctg aag gac cta        491
Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Arg His Leu Lys Asp Leu           
        130                 135                 140                       

gag gaa ggc atc caa acg ctg atg tgg agg ctg gaa gat ggc agc ccc        539
Glu Glu Gly Ile Gln Thr Leu Met Trp Arg Leu Glu Asp Gly Ser Pro           
    145                 150                 155                           

cgg act ggg cag atc ttc aat cag tcc tac agc aag ttt gac aca aaa        587
Arg Thr Gly Gln Ile Phe Asn Gln Ser Tyr Ser Lys Phe Asp Thr Lys           
160                 165                 170                 175           

tcg cac aac gat gac gca ctg ctc aag aac tac ggg ctg ctc tac tgc        635
Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys           
                180                 185                 190               

ttc agg aag gac atg gac aag gtc gag aca ttc ctg cgc atc gtg cag        683
Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln           
            195                 200                 205                   

tgc cgc tct gtg gag ggc agc tgt ggc ttc tag ctgcccgggt ggcatccctg      736
Cys Arg Ser Val Glu Gly Ser Cys Gly Phe                                   
        210                 215                                           

tgacccctcc ccagtgcctc tcctggtcgt ggaaggtgct actccagtgc ccaccagcct      796

tgtcctaata aaattaagtt gcatc                                            821


<210>  802
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  802

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Ser Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala Arg Arg Leu Tyr Gln 
        35                  40                  45              


Leu Ala Tyr Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Leu Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Val Lys Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Leu Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Arg His Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Trp Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Asn Gln Ser Tyr Ser Lys Phe Asp Thr Lys Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  803
<211>  528
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (73)..(423)

<400>  803
ctgtgaggca gtgctgtgtg gttcctgccg tccggactct ttttcctcta ctgagattca       60

tctgtgtgaa at atg agt tgg cga gga aga tcg acc tat cgg cct aga cca      111
              Met Ser Trp Arg Gly Arg Ser Thr Tyr Arg Pro Arg Pro         
              1               5                   10                      

aga cgc tac gta gag cct cct gaa atg att ggg cct atg cgg ccc gag        159
Arg Arg Tyr Val Glu Pro Pro Glu Met Ile Gly Pro Met Arg Pro Glu           
    15                  20                  25                            

cag ttc agt gat gaa gtg gaa cca gca aca cct gaa gaa ggg gaa cca        207
Gln Phe Ser Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro           
30                  35                  40                  45            

gca act caa cgt cag gat cct gca gct gct cag gag gga gag gat gag        255
Ala Thr Gln Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu           
                50                  55                  60                

gga gca tct gca ggt caa ggg ccg aag cct gaa gct gat agc cag gaa        303
Gly Ala Ser Ala Gly Gln Gly Pro Lys Pro Glu Ala Asp Ser Gln Glu           
            65                  70                  75                    

cag ggt cac cca cag act ggg tgt gag tgt gaa gat ggt cct gat ggg        351
Gln Gly His Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly           
        80                  85                  90                        

cag gag atg gac ccg cca aat cca gag gag gtg aaa acg cct gaa gaa        399
Gln Glu Met Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu           
    95                  100                 105                           

ggt gaa aag caa tca cag tgt taa aagaagacac gttgaaatga tgcaggctgc       453
Gly Glu Lys Gln Ser Gln Cys                                               
110                 115                                                   

tcctatgttg gaaatttgtt cattaaaatt ctcccaataa agctttacag ccttctgcaa      513

agaaaaaaaa aaaaa                                                       528


<210>  804
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  804

Met Ser Trp Arg Gly Arg Ser Thr Tyr Arg Pro Arg Pro Arg Arg Tyr 
1               5                   10                  15      


Val Glu Pro Pro Glu Met Ile Gly Pro Met Arg Pro Glu Gln Phe Ser 
            20                  25                  30          


Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr Gln 
        35                  40                  45              


Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala Ser 
    50                  55                  60                  


Ala Gly Gln Gly Pro Lys Pro Glu Ala Asp Ser Gln Glu Gln Gly His 
65                  70                  75                  80  


Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu Met 
                85                  90                  95      


Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Gly Glu Lys 
            100                 105                 110         


Gln Ser Gln Cys 
        115     


<210>  805
<211>  1910
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (344)..(1846)

<400>  805
ggggagctat gaaccttaag attagaccac taactcgaat ctaaatgagc tgcccttgtc       60

tcctacaaaa gaaaagttgg gcaggtaggg tattctaatg agggtttctc tttctcttaa      120

gcaaatgatg atcaaagtta actgacaaac tgtcacggaa tctgccagac ctcactctgg      180

ccttgctgct tctctccagc tcctgaactt ttctttcttc catcatgctc tgagcccatt      240

ccttgaaaac taaaaggtcc ctgactccca gtctgcagcc atcctgggcc tgctgagctc      300

tgattcaagt gcctgcctct gccccttggt gggctgaagc ttc atg gag gta tcc        355
                                                Met Glu Val Ser           
                                                1                         

acc aac ccc tcc tcc aac atc gat cca ggc gac tat gtt gaa atg aat        403
Thr Asn Pro Ser Ser Asn Ile Asp Pro Gly Asp Tyr Val Glu Met Asn           
5                   10                  15                  20            

gat tca atc acc cac cta ccc tct aaa gtg gtg ata caa gat att act        451
Asp Ser Ile Thr His Leu Pro Ser Lys Val Val Ile Gln Asp Ile Thr           
                25                  30                  35                

atg gag cta cac tgc cct ctg tgc aat gat tgg ttc cga gac cca ctg        499
Met Glu Leu His Cys Pro Leu Cys Asn Asp Trp Phe Arg Asp Pro Leu           
            40                  45                  50                    

atg cta agc tgt ggc cac aac ttc tgt gaa gcc tgt atc caa gac ttt        547
Met Leu Ser Cys Gly His Asn Phe Cys Glu Ala Cys Ile Gln Asp Phe           
        55                  60                  65                        

tgg agg ctg caa gca aag gaa aca ttc tgt cct gag tgt aag atg cta        595
Trp Arg Leu Gln Ala Lys Glu Thr Phe Cys Pro Glu Cys Lys Met Leu           
    70                  75                  80                            

tgt cag tat aac aac tgt aca ttc aac cct gta ctg gac aag ttg gta        643
Cys Gln Tyr Asn Asn Cys Thr Phe Asn Pro Val Leu Asp Lys Leu Val           
85                  90                  95                  100           

gag aag att aag aag tta ccc tta ctc aag ggc cat cca cag tgc cca        691
Glu Lys Ile Lys Lys Leu Pro Leu Leu Lys Gly His Pro Gln Cys Pro           
                105                 110                 115               

gag cat gga gag aac ctg aaa ctg ttc agt aaa cca gat ggg aaa ctg        739
Glu His Gly Glu Asn Leu Lys Leu Phe Ser Lys Pro Asp Gly Lys Leu           
            120                 125                 130                   

atc tgc ttt caa tgc aag gat gct cgg ttg tct gtg ggg cag tct aag        787
Ile Cys Phe Gln Cys Lys Asp Ala Arg Leu Ser Val Gly Gln Ser Lys           
        135                 140                 145                       

gag ttc ctg caa atc tct gat gct gtc cat ttc ttc acg gag gag ctt        835
Glu Phe Leu Gln Ile Ser Asp Ala Val His Phe Phe Thr Glu Glu Leu           
    150                 155                 160                           

gcc atc caa cag ggt caa ctg gag aca act ctg aag gag ctt cag acc        883
Ala Ile Gln Gln Gly Gln Leu Glu Thr Thr Leu Lys Glu Leu Gln Thr           
165                 170                 175                 180           

ctg agg aac atg cag aag gaa gct att gct gct cac aag gaa aac aag        931
Leu Arg Asn Met Gln Lys Glu Ala Ile Ala Ala His Lys Glu Asn Lys           
                185                 190                 195               

cta cat ctg cag caa cat gtg tcc atg gag ttt cta aag ctg cat cag        979
Leu His Leu Gln Gln His Val Ser Met Glu Phe Leu Lys Leu His Gln           
            200                 205                 210                   

ttc ctg cac agc aaa gaa aag gac att tta act gag ctc cgg gaa gag       1027
Phe Leu His Ser Lys Glu Lys Asp Ile Leu Thr Glu Leu Arg Glu Glu           
        215                 220                 225                       

ggg aaa gcc ttg aat gag gag atg gag ttg aat ctg agc cag ctt cag       1075
Gly Lys Ala Leu Asn Glu Glu Met Glu Leu Asn Leu Ser Gln Leu Gln           
    230                 235                 240                           

gag caa tgt ctc tta gcc aag gat atg ttg gtg agc att cag gca aag       1123
Glu Gln Cys Leu Leu Ala Lys Asp Met Leu Val Ser Ile Gln Ala Lys           
245                 250                 255                 260           

acg gaa caa cag aac tcc ttc gac ttt ctc aaa gac atc aca act ctc       1171
Thr Glu Gln Gln Asn Ser Phe Asp Phe Leu Lys Asp Ile Thr Thr Leu           
                265                 270                 275               

tta cat agc ttg gag caa gga atg aag gtg ctg gca acc aga gag ctt       1219
Leu His Ser Leu Glu Gln Gly Met Lys Val Leu Ala Thr Arg Glu Leu           
            280                 285                 290                   

att tcc aga aag ctg aac ctg ggc cag tac aaa ggt cct atc cag tac       1267
Ile Ser Arg Lys Leu Asn Leu Gly Gln Tyr Lys Gly Pro Ile Gln Tyr           
        295                 300                 305                       

atg gta tgg agg gaa atg cag gac act ctc tgc cca ggc ctg tct cca       1315
Met Val Trp Arg Glu Met Gln Asp Thr Leu Cys Pro Gly Leu Ser Pro           
    310                 315                 320                           

cta act ctg gac cct aaa aca gct cac cca aat ctg gtg ctc tcc aaa       1363
Leu Thr Leu Asp Pro Lys Thr Ala His Pro Asn Leu Val Leu Ser Lys           
325                 330                 335                 340           

agc caa acc agc gtc tgg cat ggt gac att aag aag ata atg cct gat       1411
Ser Gln Thr Ser Val Trp His Gly Asp Ile Lys Lys Ile Met Pro Asp           
                345                 350                 355               

gat cct gag agg ttt gac tca agt gtg gct gta ctg ggc tca aga ggc       1459
Asp Pro Glu Arg Phe Asp Ser Ser Val Ala Val Leu Gly Ser Arg Gly           
            360                 365                 370                   

ttc acc tct gga aag tgg tac tgg gaa gta gaa gta gca aag aag aca       1507
Phe Thr Ser Gly Lys Trp Tyr Trp Glu Val Glu Val Ala Lys Lys Thr           
        375                 380                 385                       

aaa tgg aca gtt gga gtt gtc aga gaa tcc atc att cgg aag ggc agc       1555
Lys Trp Thr Val Gly Val Val Arg Glu Ser Ile Ile Arg Lys Gly Ser           
    390                 395                 400                           

tgt cct cta act cct gag caa gga ttc tgg ctt tta aga cta agg aac       1603
Cys Pro Leu Thr Pro Glu Gln Gly Phe Trp Leu Leu Arg Leu Arg Asn           
405                 410                 415                 420           

caa act gat cta aag gct ctg gat ttg cct tct ttc agt ctg aca ctg       1651
Gln Thr Asp Leu Lys Ala Leu Asp Leu Pro Ser Phe Ser Leu Thr Leu           
                425                 430                 435               

act aac aac ctc gac aag gtg ggc ata tac ctg gat tat gaa gga gga       1699
Thr Asn Asn Leu Asp Lys Val Gly Ile Tyr Leu Asp Tyr Glu Gly Gly           
            440                 445                 450                   

cag ttg tcc ttc tac aat gct aaa acc atg act cac att tac acc ttc       1747
Gln Leu Ser Phe Tyr Asn Ala Lys Thr Met Thr His Ile Tyr Thr Phe           
        455                 460                 465                       

agt aac act ttc atg gag aaa ctt tat ccc tac ttc tgc ccc tgc ctt       1795
Ser Asn Thr Phe Met Glu Lys Leu Tyr Pro Tyr Phe Cys Pro Cys Leu           
    470                 475                 480                           

aat gat ggt gga gag aat aaa gaa cca ttg cac atc tta cat cca cag       1843
Asn Asp Gly Gly Glu Asn Lys Glu Pro Leu His Ile Leu His Pro Gln           
485                 490                 495                 500           

taa tgagtcataa tattatacaa attcagagtg ttattaaaga ggtattgaaa            1896

tatttaaaaa aaaa                                                       1910


<210>  806
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  806

Met Glu Val Ser Thr Asn Pro Ser Ser Asn Ile Asp Pro Gly Asp Tyr 
1               5                   10                  15      


Val Glu Met Asn Asp Ser Ile Thr His Leu Pro Ser Lys Val Val Ile 
            20                  25                  30          


Gln Asp Ile Thr Met Glu Leu His Cys Pro Leu Cys Asn Asp Trp Phe 
        35                  40                  45              


Arg Asp Pro Leu Met Leu Ser Cys Gly His Asn Phe Cys Glu Ala Cys 
    50                  55                  60                  


Ile Gln Asp Phe Trp Arg Leu Gln Ala Lys Glu Thr Phe Cys Pro Glu 
65                  70                  75                  80  


Cys Lys Met Leu Cys Gln Tyr Asn Asn Cys Thr Phe Asn Pro Val Leu 
                85                  90                  95      


Asp Lys Leu Val Glu Lys Ile Lys Lys Leu Pro Leu Leu Lys Gly His 
            100                 105                 110         


Pro Gln Cys Pro Glu His Gly Glu Asn Leu Lys Leu Phe Ser Lys Pro 
        115                 120                 125             


Asp Gly Lys Leu Ile Cys Phe Gln Cys Lys Asp Ala Arg Leu Ser Val 
    130                 135                 140                 


Gly Gln Ser Lys Glu Phe Leu Gln Ile Ser Asp Ala Val His Phe Phe 
145                 150                 155                 160 


Thr Glu Glu Leu Ala Ile Gln Gln Gly Gln Leu Glu Thr Thr Leu Lys 
                165                 170                 175     


Glu Leu Gln Thr Leu Arg Asn Met Gln Lys Glu Ala Ile Ala Ala His 
            180                 185                 190         


Lys Glu Asn Lys Leu His Leu Gln Gln His Val Ser Met Glu Phe Leu 
        195                 200                 205             


Lys Leu His Gln Phe Leu His Ser Lys Glu Lys Asp Ile Leu Thr Glu 
    210                 215                 220                 


Leu Arg Glu Glu Gly Lys Ala Leu Asn Glu Glu Met Glu Leu Asn Leu 
225                 230                 235                 240 


Ser Gln Leu Gln Glu Gln Cys Leu Leu Ala Lys Asp Met Leu Val Ser 
                245                 250                 255     


Ile Gln Ala Lys Thr Glu Gln Gln Asn Ser Phe Asp Phe Leu Lys Asp 
            260                 265                 270         


Ile Thr Thr Leu Leu His Ser Leu Glu Gln Gly Met Lys Val Leu Ala 
        275                 280                 285             


Thr Arg Glu Leu Ile Ser Arg Lys Leu Asn Leu Gly Gln Tyr Lys Gly 
    290                 295                 300                 


Pro Ile Gln Tyr Met Val Trp Arg Glu Met Gln Asp Thr Leu Cys Pro 
305                 310                 315                 320 


Gly Leu Ser Pro Leu Thr Leu Asp Pro Lys Thr Ala His Pro Asn Leu 
                325                 330                 335     


Val Leu Ser Lys Ser Gln Thr Ser Val Trp His Gly Asp Ile Lys Lys 
            340                 345                 350         


Ile Met Pro Asp Asp Pro Glu Arg Phe Asp Ser Ser Val Ala Val Leu 
        355                 360                 365             


Gly Ser Arg Gly Phe Thr Ser Gly Lys Trp Tyr Trp Glu Val Glu Val 
    370                 375                 380                 


Ala Lys Lys Thr Lys Trp Thr Val Gly Val Val Arg Glu Ser Ile Ile 
385                 390                 395                 400 


Arg Lys Gly Ser Cys Pro Leu Thr Pro Glu Gln Gly Phe Trp Leu Leu 
                405                 410                 415     


Arg Leu Arg Asn Gln Thr Asp Leu Lys Ala Leu Asp Leu Pro Ser Phe 
            420                 425                 430         


Ser Leu Thr Leu Thr Asn Asn Leu Asp Lys Val Gly Ile Tyr Leu Asp 
        435                 440                 445             


Tyr Glu Gly Gly Gln Leu Ser Phe Tyr Asn Ala Lys Thr Met Thr His 
    450                 455                 460                 


Ile Tyr Thr Phe Ser Asn Thr Phe Met Glu Lys Leu Tyr Pro Tyr Phe 
465                 470                 475                 480 


Cys Pro Cys Leu Asn Asp Gly Gly Glu Asn Lys Glu Pro Leu His Ile 
                485                 490                 495     


Leu His Pro Gln 
            500 


<210>  807
<211>  1180
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (70)..(579)

<400>  807
gagccacgat tcagtcccct ggactgtaga taaagaccct ttcttgccag gtgctgagac       60

aaccacact atg aga ggc act cca gga gac gct gat ggt gga gga agg gcc      111
          Met Arg Gly Thr Pro Gly Asp Ala Asp Gly Gly Gly Arg Ala         
          1               5                   10                          

gtc tat caa tca atg tgt aaa cct att act ggg act att aat gat ttg        159
Val Tyr Gln Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu           
15                  20                  25                  30            

aat cag caa gtg tgg acc ctt cag ggt cag aac ctt gtg gca gtt cca        207
Asn Gln Gln Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro           
                35                  40                  45                

cga agt gac agt gtg acc cca gtc act gtt gct gtt atc aca tgc aag        255
Arg Ser Asp Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys           
            50                  55                  60                    

tat cca gag gct ctt gag caa ggc aga ggg gat ccc att tat ttg gga        303
Tyr Pro Glu Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly           
        65                  70                  75                        

atc cag aat cca gaa atg tgt ttg tat tgt gag aag gtt gga gaa cag        351
Ile Gln Asn Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln           
    80                  85                  90                            

ccc aca ttg cag cta aaa gag cag aag atc atg gat ctg tat ggc caa        399
Pro Thr Leu Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln           
95                  100                 105                 110           

ccc gag ccc gtg aaa ccc ttc ctt ttc tac cgt gcc aag act ggt agg        447
Pro Glu Pro Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg           
                115                 120                 125               

acc tcc acc ctt gag tct gtg gcc ttc ccg gac tgg ttc att gcc tcc        495
Thr Ser Thr Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser           
            130                 135                 140                   

tcc aag aga gac cag ccc atc att ctg act tca gaa ctt ggg aag tca        543
Ser Lys Arg Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser           
        145                 150                 155                       

tac aac act gcc ttt gaa tta aat ata aat gac tga actcagccta             589
Tyr Asn Thr Ala Phe Glu Leu Asn Ile Asn Asp                               
    160                 165                                               

gaggtggcag cttggtcttt gtcttaaagt ttctggttcc caatgtgttt tcgtctacat      649

tttcttagtg tcattttcac gctggtgctg agacaggggc aaggctgctg ttatcatctc      709

attttataat gaagaagaag caattacttc atagcaactg aagaacagga tgtggcctca      769

gaagcaggag agctgggtgg tataaggctg tcctctcaag ctggtgctgt gtaggccaca      829

aggcatctgc atgagtgact ttaagactca aagaccaaac actgagcttt cttctagggg      889

tgggtatgaa gatgcttcag agctcatgcg cgttacccac gatggcatga ctagcacaga      949

gctgatctct gtttctgttt tgctttattc cctcttggga tgatatcatc cagtctttat     1009

atgttgccaa tatacctcat tgtgtgtaat agaaccttct tagcattaag accttgtaaa     1069

caaaaataat tcttgtgtta agttaaatca tttttgtcct aattgtaatg tgtaatctta     1129

aagttaaata aactttgtgt atttatataa taataaagct aaaactgata t              1180


<210>  808
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  808

Met Arg Gly Thr Pro Gly Asp Ala Asp Gly Gly Gly Arg Ala Val Tyr 
1               5                   10                  15      


Gln Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln 
            20                  25                  30          


Gln Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg Ser 
        35                  40                  45              


Asp Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro 
    50                  55                  60                  


Glu Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile Gln 
65                  70                  75                  80  


Asn Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro Thr 
                85                  90                  95      


Leu Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu 
            100                 105                 110         


Pro Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr Ser 
        115                 120                 125             


Thr Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser Lys 
    130                 135                 140                 


Arg Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn 
145                 150                 155                 160 


Thr Ala Phe Glu Leu Asn Ile Asn Asp 
                165                 


<210>  809
<211>  5325
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (291)..(4775)

<400>  809
gtgaattatg attttcctta gtcagaagca ctcattttta cccatgtaga ccatccttag       60

gaattaaata ttggttattt aatgtagatt ataatgggaa gctgattttt ttcacaatgg      120

catatttcaa ggacttggtt ccaaactgag ctgaagcttc ccaatgcgtt ttgtacagtc      180

tgggaaaaac tgtgctgcac tggcccactt ttgaaggcca tcatgctctg taatataagg      240

atatcatctt attgctgata tctttggaga gtccctagca gacacagaaa atg aat         296
                                                       Met Asn            
                                                       1                  

gga ggc aaa gag tgt gac gga ggg gac aag gaa gga ggt ctt cca gct        344
Gly Gly Lys Glu Cys Asp Gly Gly Asp Lys Glu Gly Gly Leu Pro Ala           
        5                   10                  15                        

ata caa gtt cct gtg ggt tgg cag cgt cgt gtg gat caa aat gga gtg        392
Ile Gln Val Pro Val Gly Trp Gln Arg Arg Val Asp Gln Asn Gly Val           
    20                  25                  30                            

ctt tat gtc agt ccc agt ggg tct ttg tta tct tgc ttg gag cag gtt        440
Leu Tyr Val Ser Pro Ser Gly Ser Leu Leu Ser Cys Leu Glu Gln Val           
35                  40                  45                  50            

aaa aca tac ctg ctt act gat gga aca tgc aag tgt ggc ttg gaa tgt        488
Lys Thr Tyr Leu Leu Thr Asp Gly Thr Cys Lys Cys Gly Leu Glu Cys           
                55                  60                  65                

cct ctt att ctt ccc aag gta ttt aat ttt gat cct gga gct gct gtg        536
Pro Leu Ile Leu Pro Lys Val Phe Asn Phe Asp Pro Gly Ala Ala Val           
            70                  75                  80                    

aaa cag aga acc gca gaa gat gtt aag gca gat gaa gat gtc aca aag        584
Lys Gln Arg Thr Ala Glu Asp Val Lys Ala Asp Glu Asp Val Thr Lys           
        85                  90                  95                        

cta tgc ata cat aaa aga aaa att att gca gtg gcc aca ctt cat aaa        632
Leu Cys Ile His Lys Arg Lys Ile Ile Ala Val Ala Thr Leu His Lys           
    100                 105                 110                           

agc atg gaa gcc cca cat cct tct ctg gtg ctc acc agt ccc gga gga        680
Ser Met Glu Ala Pro His Pro Ser Leu Val Leu Thr Ser Pro Gly Gly           
115                 120                 125                 130           

gga aca aat gca act cca gta gta cct tct cgg gca gca act cca aga        728
Gly Thr Asn Ala Thr Pro Val Val Pro Ser Arg Ala Ala Thr Pro Arg           
                135                 140                 145               

tca gta aga aat aag tct cat gaa gga att aca aat tct gta atg cct        776
Ser Val Arg Asn Lys Ser His Glu Gly Ile Thr Asn Ser Val Met Pro           
            150                 155                 160                   

gaa tgt aag aat cct ttc aag tta atg att gga tca tca aat gcc atg        824
Glu Cys Lys Asn Pro Phe Lys Leu Met Ile Gly Ser Ser Asn Ala Met           
        165                 170                 175                       

gga agg cta tat gta caa gaa ctg cct gga agc caa caa caa gaa ctc        872
Gly Arg Leu Tyr Val Gln Glu Leu Pro Gly Ser Gln Gln Gln Glu Leu           
    180                 185                 190                           

cac cct gtc tac ccc cga cag aga ttg ggc agc agt gaa cat gga cag        920
His Pro Val Tyr Pro Arg Gln Arg Leu Gly Ser Ser Glu His Gly Gln           
195                 200                 205                 210           

aaa tct cca ttc cgt ggc agc cat gga ggc ctg ccc agc cca gcg tca        968
Lys Ser Pro Phe Arg Gly Ser His Gly Gly Leu Pro Ser Pro Ala Ser           
                215                 220                 225               

tca ggt tcc cag ata tat gga gat ggt tca atc tct cca agg act gac       1016
Ser Gly Ser Gln Ile Tyr Gly Asp Gly Ser Ile Ser Pro Arg Thr Asp           
            230                 235                 240                   

cca ctt gga agt cct gat gtt ttc aca aga agt aat cct ggt ttt cat       1064
Pro Leu Gly Ser Pro Asp Val Phe Thr Arg Ser Asn Pro Gly Phe His           
        245                 250                 255                       

gga gct ccc aat tct agt cct att cac ctg aat agg act cct ctt tct       1112
Gly Ala Pro Asn Ser Ser Pro Ile His Leu Asn Arg Thr Pro Leu Ser           
    260                 265                 270                           

cca cct tca gta atg cta cat ggt tct cct gta cag tca tcc tgt gca       1160
Pro Pro Ser Val Met Leu His Gly Ser Pro Val Gln Ser Ser Cys Ala           
275                 280                 285                 290           

atg gct gga agg act aat ata cct ctt tcc cca acc ttg act aca aag       1208
Met Ala Gly Arg Thr Asn Ile Pro Leu Ser Pro Thr Leu Thr Thr Lys           
                295                 300                 305               

agt cca gta atg aaa aaa cca atg tgt aat ttt tca act aat atg gaa       1256
Ser Pro Val Met Lys Lys Pro Met Cys Asn Phe Ser Thr Asn Met Glu           
            310                 315                 320                   

ata cca cga gca atg ttc cac cac aaa cca ccc caa ggc cca cct ccc       1304
Ile Pro Arg Ala Met Phe His His Lys Pro Pro Gln Gly Pro Pro Pro           
        325                 330                 335                       

cct cct cca cct tct tgt gct ctt cag aaa aag cca tta aca tct gag       1352
Pro Pro Pro Pro Ser Cys Ala Leu Gln Lys Lys Pro Leu Thr Ser Glu           
    340                 345                 350                           

aaa gat cca ctt ggc att ctt gac cct att cct agt aaa cca gtg aat       1400
Lys Asp Pro Leu Gly Ile Leu Asp Pro Ile Pro Ser Lys Pro Val Asn           
355                 360                 365                 370           

cag aac cct gtt atc att aat cca acc agt ttc cat tca aat gtc cac       1448
Gln Asn Pro Val Ile Ile Asn Pro Thr Ser Phe His Ser Asn Val His           
                375                 380                 385               

tct cag gta cct atg atg aat gta agc atg cct cct gct gtt gtt cct       1496
Ser Gln Val Pro Met Met Asn Val Ser Met Pro Pro Ala Val Val Pro           
            390                 395                 400                   

ttg cca agt aat ctc cca ttg cca act gta aaa cct ggt cac atg aat       1544
Leu Pro Ser Asn Leu Pro Leu Pro Thr Val Lys Pro Gly His Met Asn           
        405                 410                 415                       

cat ggg agt cat gta caa aga gtt cag cat tca gct tca acc tcc ctg       1592
His Gly Ser His Val Gln Arg Val Gln His Ser Ala Ser Thr Ser Leu           
    420                 425                 430                           

tcc cct tct cca gtg aca tcc ccc gtg cac atg atg ggg act gga att       1640
Ser Pro Ser Pro Val Thr Ser Pro Val His Met Met Gly Thr Gly Ile           
435                 440                 445                 450           

gga agg att gag gca tcg ccc caa aga tca cgc tca tct tcc aca tca       1688
Gly Arg Ile Glu Ala Ser Pro Gln Arg Ser Arg Ser Ser Ser Thr Ser           
                455                 460                 465               

tca gat cat gga aat ttc atg atg cca cct gta gga ccc cag gcc act       1736
Ser Asp His Gly Asn Phe Met Met Pro Pro Val Gly Pro Gln Ala Thr           
            470                 475                 480                   

tct agt ggt att aag gtt cca ccc agg tca cca agg tca aca ata ggg       1784
Ser Ser Gly Ile Lys Val Pro Pro Arg Ser Pro Arg Ser Thr Ile Gly           
        485                 490                 495                       

tcc cca agg cca tca atg cca tca agc cct tct acc aag tcc gat gga       1832
Ser Pro Arg Pro Ser Met Pro Ser Ser Pro Ser Thr Lys Ser Asp Gly           
    500                 505                 510                           

cat cat cag tac aag gat atc cct aac cca tta att gct gga ata agt       1880
His His Gln Tyr Lys Asp Ile Pro Asn Pro Leu Ile Ala Gly Ile Ser           
515                 520                 525                 530           

aat gta cta aat acc cca agc agt gca gct ttt cct act gca tct gcc       1928
Asn Val Leu Asn Thr Pro Ser Ser Ala Ala Phe Pro Thr Ala Ser Ala           
                535                 540                 545               

gga agt agt tct gta aag agt cag cct ggt ttg ctg gga atg cct tta       1976
Gly Ser Ser Ser Val Lys Ser Gln Pro Gly Leu Leu Gly Met Pro Leu           
            550                 555                 560                   

aat cag atc ttg aac cag cac aat gct gcc tcc ttt cca gca agt agt       2024
Asn Gln Ile Leu Asn Gln His Asn Ala Ala Ser Phe Pro Ala Ser Ser           
        565                 570                 575                       

tta ctc tca gca gca gcc aaa gca cag cta gca aat caa aac aaa ctt       2072
Leu Leu Ser Ala Ala Ala Lys Ala Gln Leu Ala Asn Gln Asn Lys Leu           
    580                 585                 590                           

gct ggt aac aac agt agc agc agt agc aat tct gga gct gtt gcc ggc       2120
Ala Gly Asn Asn Ser Ser Ser Ser Ser Asn Ser Gly Ala Val Ala Gly           
595                 600                 605                 610           

agt ggc aac act gaa gga cat agc act tta aac acc atg ttc cct cct       2168
Ser Gly Asn Thr Glu Gly His Ser Thr Leu Asn Thr Met Phe Pro Pro           
                615                 620                 625               

act gcc aac atg ctt ctc cca aca ggt gaa ggg caa agt ggt cga gca       2216
Thr Ala Asn Met Leu Leu Pro Thr Gly Glu Gly Gln Ser Gly Arg Ala           
            630                 635                 640                   

gca cta aga gat aag ctg atg tct cag caa aaa gac gca ttg cgg aaa       2264
Ala Leu Arg Asp Lys Leu Met Ser Gln Gln Lys Asp Ala Leu Arg Lys           
        645                 650                 655                       

aga aaa caa cca cct acg aca gtg ttg agt ttg ctc aga cag tct caa       2312
Arg Lys Gln Pro Pro Thr Thr Val Leu Ser Leu Leu Arg Gln Ser Gln           
    660                 665                 670                           

atg gat agt tct gca gtt cct aaa cct gga cct gac ttg cta agg aag       2360
Met Asp Ser Ser Ala Val Pro Lys Pro Gly Pro Asp Leu Leu Arg Lys           
675                 680                 685                 690           

cag ggt cag ggt tca ttt ccc atc agt tca atg tct cag tta cta cag       2408
Gln Gly Gln Gly Ser Phe Pro Ile Ser Ser Met Ser Gln Leu Leu Gln           
                695                 700                 705               

tct atg agt tgt caa agc tct cac ttg agt agc aat agt acc ccg ggt       2456
Ser Met Ser Cys Gln Ser Ser His Leu Ser Ser Asn Ser Thr Pro Gly           
            710                 715                 720                   

tgt ggg gcc tca aat act gct ttg cct tgc tct gct aac cag ctg cat       2504
Cys Gly Ala Ser Asn Thr Ala Leu Pro Cys Ser Ala Asn Gln Leu His           
        725                 730                 735                       

ttt aca gat ccc agt atg aac tct agt gtt ctt cag aac ata cct tta       2552
Phe Thr Asp Pro Ser Met Asn Ser Ser Val Leu Gln Asn Ile Pro Leu           
    740                 745                 750                           

aga ggg gaa gcc gtg cac tgc cac aat gca aac act aac ttt gtt cac       2600
Arg Gly Glu Ala Val His Cys His Asn Ala Asn Thr Asn Phe Val His           
755                 760                 765                 770           

agt aac agt cca gtc ccc aac cac cat ctt gca ggt tta ata aat cag       2648
Ser Asn Ser Pro Val Pro Asn His His Leu Ala Gly Leu Ile Asn Gln           
                775                 780                 785               

att cag gct agc ggg aac tgt ggg atg ctc agt cag tcg ggc atg gct       2696
Ile Gln Ala Ser Gly Asn Cys Gly Met Leu Ser Gln Ser Gly Met Ala           
            790                 795                 800                   

tta gga aat tcc tta cat ccc aat cca cct cag tca aga att tca acg       2744
Leu Gly Asn Ser Leu His Pro Asn Pro Pro Gln Ser Arg Ile Ser Thr           
        805                 810                 815                       

tcc tcc act cca gtg ata cca aac agc att gtt agc agc tat aat caa       2792
Ser Ser Thr Pro Val Ile Pro Asn Ser Ile Val Ser Ser Tyr Asn Gln           
    820                 825                 830                           

aca agt tct gaa gca ggc ggt tca gga cca tca tcc tcc ata gcc ata       2840
Thr Ser Ser Glu Ala Gly Gly Ser Gly Pro Ser Ser Ser Ile Ala Ile           
835                 840                 845                 850           

gcg ggc acc aac cac cct gcc atc aca aag aca aca tct gtt ctt caa       2888
Ala Gly Thr Asn His Pro Ala Ile Thr Lys Thr Thr Ser Val Leu Gln           
                855                 860                 865               

gat ggc gtc ata gtc acc act gca gct gga aac cca ctg cag agt cag       2936
Asp Gly Val Ile Val Thr Thr Ala Ala Gly Asn Pro Leu Gln Ser Gln           
            870                 875                 880                   

cta ccc att ggg agt gat ttt cct ttt gtt ggc cag gag cac gca ctt       2984
Leu Pro Ile Gly Ser Asp Phe Pro Phe Val Gly Gln Glu His Ala Leu           
        885                 890                 895                       

cat ttt cca tcc aac agc act tca aac aac cat ctt cca cac ccc ttg       3032
His Phe Pro Ser Asn Ser Thr Ser Asn Asn His Leu Pro His Pro Leu           
    900                 905                 910                           

aac ccc agc ctc ctc agt tct cta cct atc tct ttg cca gtg aat caa       3080
Asn Pro Ser Leu Leu Ser Ser Leu Pro Ile Ser Leu Pro Val Asn Gln           
915                 920                 925                 930           

cag cat ctc cta aac cag aat cta tta aat atc ctc cag cct tca gca       3128
Gln His Leu Leu Asn Gln Asn Leu Leu Asn Ile Leu Gln Pro Ser Ala           
                935                 940                 945               

gga gaa ggt gat atg tca tca ata aac aat act ttg agt aac cat caa       3176
Gly Glu Gly Asp Met Ser Ser Ile Asn Asn Thr Leu Ser Asn His Gln           
            950                 955                 960                   

ctg act cat cta cag tcg ctg tta aac aac aat cag atg ttt cct cca       3224
Leu Thr His Leu Gln Ser Leu Leu Asn Asn Asn Gln Met Phe Pro Pro           
        965                 970                 975                       

aat cag caa cag cag caa ctt ctc cag ggg tac cag aat ctc cag gcg       3272
Asn Gln Gln Gln Gln Gln Leu Leu Gln Gly Tyr Gln Asn Leu Gln Ala           
    980                 985                 990                           

ttc caa gga cag tcc aca  att cct tgc cca gct  aac aat aac ccc         3317
Phe Gln Gly Gln Ser Thr  Ile Pro Cys Pro Ala  Asn Asn Asn Pro             
995                 1000                 1005                             

atg  gct tgt ctg ttt cag  aac ttt cag gtg aga  atg cag gaa gat        3362
Met  Ala Cys Leu Phe Gln  Asn Phe Gln Val Arg  Met Gln Glu Asp            
1010                 1015                 1020                            

gca  gct ctc cta aac aaa  aga ata agc act cag  cct ggg ctc aca        3407
Ala  Ala Leu Leu Asn Lys  Arg Ile Ser Thr Gln  Pro Gly Leu Thr            
1025                 1030                 1035                            

gca  ctt cct gag aat cca  aac act aca ctt cca  cct ttt caa gat        3452
Ala  Leu Pro Glu Asn Pro  Asn Thr Thr Leu Pro  Pro Phe Gln Asp            
1040                 1045                 1050                            

aca  cct tgt gag ttg caa  ccg agg att gac cca  tct ctt ggt caa        3497
Thr  Pro Cys Glu Leu Gln  Pro Arg Ile Asp Pro  Ser Leu Gly Gln            
1055                 1060                 1065                            

cag  gtg aag gat ggc ctc  gtt gtg ggt ggc cca  ggt gat gct tcc        3542
Gln  Val Lys Asp Gly Leu  Val Val Gly Gly Pro  Gly Asp Ala Ser            
1070                 1075                 1080                            

gta  gat gcc att tac aaa  gca gtt gtc gat gca  gcc agc aaa gga        3587
Val  Asp Ala Ile Tyr Lys  Ala Val Val Asp Ala  Ala Ser Lys Gly            
1085                 1090                 1095                            

atg  cag gtt gtc atc acc  act gca gtc aac agt  aca act cag atc        3632
Met  Gln Val Val Ile Thr  Thr Ala Val Asn Ser  Thr Thr Gln Ile            
1100                 1105                 1110                            

agc  ccc att cca gct ctg  agt gcc atg agt gcc  ttc act gcc tca        3677
Ser  Pro Ile Pro Ala Leu  Ser Ala Met Ser Ala  Phe Thr Ala Ser            
1115                 1120                 1125                            

att  ggt gac cca tta aat  ctc tcc agt gct gtc  agt gcg gtc att        3722
Ile  Gly Asp Pro Leu Asn  Leu Ser Ser Ala Val  Ser Ala Val Ile            
1130                 1135                 1140                            

cat  gga cgg aac atg gga  ggt gtt gat cat gat  ggt agg ctg agg        3767
His  Gly Arg Asn Met Gly  Gly Val Asp His Asp  Gly Arg Leu Arg            
1145                 1150                 1155                            

aat  tca aga ggg gct cgg  ctg ccc aag aat cta  gac cat ggg aaa        3812
Asn  Ser Arg Gly Ala Arg  Leu Pro Lys Asn Leu  Asp His Gly Lys            
1160                 1165                 1170                            

aat  gtg aac gaa gga gat  ggg ttt gaa tat ttc  aag tca gca agt        3857
Asn  Val Asn Glu Gly Asp  Gly Phe Glu Tyr Phe  Lys Ser Ala Ser            
1175                 1180                 1185                            

tgc  cac aca tcc aaa aaa  cag tgg gac ggg gag  caa agc ccc aga        3902
Cys  His Thr Ser Lys Lys  Gln Trp Asp Gly Glu  Gln Ser Pro Arg            
1190                 1195                 1200                            

ggg  gag cga aac agg tgg  aag tac gag gaa ttt  tta gat cat cca        3947
Gly  Glu Arg Asn Arg Trp  Lys Tyr Glu Glu Phe  Leu Asp His Pro            
1205                 1210                 1215                            

ggc  cat atc cac agt agt  cct tgt cat gaa agg  ccc aac aat gtc        3992
Gly  His Ile His Ser Ser  Pro Cys His Glu Arg  Pro Asn Asn Val            
1220                 1225                 1230                            

tct  aca ctg cca ttt ctg  cct ggg gaa cag cac  cca ata ctg tta        4037
Ser  Thr Leu Pro Phe Leu  Pro Gly Glu Gln His  Pro Ile Leu Leu            
1235                 1240                 1245                            

cca  cca aga aac tgt cca  ggg gat aaa att cta  gag gaa aat ttc        4082
Pro  Pro Arg Asn Cys Pro  Gly Asp Lys Ile Leu  Glu Glu Asn Phe            
1250                 1255                 1260                            

agg  tat aat aac tac aaa  aga act atg atg agt  ttt aag gag aga        4127
Arg  Tyr Asn Asn Tyr Lys  Arg Thr Met Met Ser  Phe Lys Glu Arg            
1265                 1270                 1275                            

cta  gag aac act gtg gaa  aga tgt gca cac ata  aat ggg aat aga        4172
Leu  Glu Asn Thr Val Glu  Arg Cys Ala His Ile  Asn Gly Asn Arg            
1280                 1285                 1290                            

cct  cga cag agt cgg gga  ttt gga gag ctg cta  agc act gca aag        4217
Pro  Arg Gln Ser Arg Gly  Phe Gly Glu Leu Leu  Ser Thr Ala Lys            
1295                 1300                 1305                            

caa  gac ctg gtc cta gag  gag cag tct cca agt  tcc tca aat agt        4262
Gln  Asp Leu Val Leu Glu  Glu Gln Ser Pro Ser  Ser Ser Asn Ser            
1310                 1315                 1320                            

ttg  gaa aat tct ctg gtc  aaa gac tac atc cat  tac aat gga gac        4307
Leu  Glu Asn Ser Leu Val  Lys Asp Tyr Ile His  Tyr Asn Gly Asp            
1325                 1330                 1335                            

ttt  aat gcc aaa agc gtt  aat ggg tgt gtg cct  agc cct tca gat        4352
Phe  Asn Ala Lys Ser Val  Asn Gly Cys Val Pro  Ser Pro Ser Asp            
1340                 1345                 1350                            

gct  aaa agc att agt agt  gaa gat gac cta agg  aac cca gac tcc        4397
Ala  Lys Ser Ile Ser Ser  Glu Asp Asp Leu Arg  Asn Pro Asp Ser            
1355                 1360                 1365                            

ccc  tct tca aat gaa ttg  ata cat tat aga cca  agg acg ttc aat        4442
Pro  Ser Ser Asn Glu Leu  Ile His Tyr Arg Pro  Arg Thr Phe Asn            
1370                 1375                 1380                            

gtt  ggc gac ttg gtc tgg  ggc caa atc aaa gga  ctg act tcc tgg        4487
Val  Gly Asp Leu Val Trp  Gly Gln Ile Lys Gly  Leu Thr Ser Trp            
1385                 1390                 1395                            

cct  gga aaa tta gta aga  gaa gac gac gtt cac  aat tca tgt caa        4532
Pro  Gly Lys Leu Val Arg  Glu Asp Asp Val His  Asn Ser Cys Gln            
1400                 1405                 1410                            

caa  agc ccc gag gaa ggg  aag gtg gag ccc gag  aag ttg aag aca        4577
Gln  Ser Pro Glu Glu Gly  Lys Val Glu Pro Glu  Lys Leu Lys Thr            
1415                 1420                 1425                            

cta  aca gaa ggt ttg gaa  gcc tac agc cgt gtc  cgg aaa agg aac        4622
Leu  Thr Glu Gly Leu Glu  Ala Tyr Ser Arg Val  Arg Lys Arg Asn            
1430                 1435                 1440                            

aga  aaa agt gga aag cta  aat aac cat tta gaa  gct gct att cat        4667
Arg  Lys Ser Gly Lys Leu  Asn Asn His Leu Glu  Ala Ala Ile His            
1445                 1450                 1455                            

gag  gcc atg agt gaa ctg  gac aaa atg tct ggg  act gta cac caa        4712
Glu  Ala Met Ser Glu Leu  Asp Lys Met Ser Gly  Thr Val His Gln            
1460                 1465                 1470                            

atc  cca cag ggt gac aga  caa atg aga ccc ccc  aaa ccc aag agg        4757
Ile  Pro Gln Gly Asp Arg  Gln Met Arg Pro Pro  Lys Pro Lys Arg            
1475                 1480                 1485                            

agg  aag atc tcc aga taa cagagactac tccactaatg cgcagtgttt             4805
Arg  Lys Ile Ser Arg                                                      
1490                                                                      

attaaaggaa catgcacaga tgtatctgta tataggtatt gatatagcca cagttatatc     4865

aatatttaga ctatggcaga tagctaccac caccacaggg tgctaaaaga aacagtgata     4925

caaaattttt ttgatcagga aggataatga atgctggaaa agccaatcaa agtctctgtg     4985

tgatgagagt gatcaatggt caagagatta ctgagaaact ctttttctat aatactaaat     5045

tgtgattata agaaatagtc caaatgtttc tgaagaattt tcaatgttgt atatagaaaa     5105

tacagaattt catggtgata tcagaaatgt aaatattgta cagtattgtc atgtacaagc     5165

gtacctaatg cacactttat cttttattgt acaaagaaat agtgtacaaa attctttggt     5225

ttctatggag tacacctacc agagactacc agtgtaaagt gataaataaa aatacaacct     5285

aaatgctttt ctatgataat gtaaaaaaaa aaaaaaaaaa                           5325


<210>  810
<211>  1494
<212>  PRT
<213>  Homo sapiens

<400>  810

Met Asn Gly Gly Lys Glu Cys Asp Gly Gly Asp Lys Glu Gly Gly Leu 
1               5                   10                  15      


Pro Ala Ile Gln Val Pro Val Gly Trp Gln Arg Arg Val Asp Gln Asn 
            20                  25                  30          


Gly Val Leu Tyr Val Ser Pro Ser Gly Ser Leu Leu Ser Cys Leu Glu 
        35                  40                  45              


Gln Val Lys Thr Tyr Leu Leu Thr Asp Gly Thr Cys Lys Cys Gly Leu 
    50                  55                  60                  


Glu Cys Pro Leu Ile Leu Pro Lys Val Phe Asn Phe Asp Pro Gly Ala 
65                  70                  75                  80  


Ala Val Lys Gln Arg Thr Ala Glu Asp Val Lys Ala Asp Glu Asp Val 
                85                  90                  95      


Thr Lys Leu Cys Ile His Lys Arg Lys Ile Ile Ala Val Ala Thr Leu 
            100                 105                 110         


His Lys Ser Met Glu Ala Pro His Pro Ser Leu Val Leu Thr Ser Pro 
        115                 120                 125             


Gly Gly Gly Thr Asn Ala Thr Pro Val Val Pro Ser Arg Ala Ala Thr 
    130                 135                 140                 


Pro Arg Ser Val Arg Asn Lys Ser His Glu Gly Ile Thr Asn Ser Val 
145                 150                 155                 160 


Met Pro Glu Cys Lys Asn Pro Phe Lys Leu Met Ile Gly Ser Ser Asn 
                165                 170                 175     


Ala Met Gly Arg Leu Tyr Val Gln Glu Leu Pro Gly Ser Gln Gln Gln 
            180                 185                 190         


Glu Leu His Pro Val Tyr Pro Arg Gln Arg Leu Gly Ser Ser Glu His 
        195                 200                 205             


Gly Gln Lys Ser Pro Phe Arg Gly Ser His Gly Gly Leu Pro Ser Pro 
    210                 215                 220                 


Ala Ser Ser Gly Ser Gln Ile Tyr Gly Asp Gly Ser Ile Ser Pro Arg 
225                 230                 235                 240 


Thr Asp Pro Leu Gly Ser Pro Asp Val Phe Thr Arg Ser Asn Pro Gly 
                245                 250                 255     


Phe His Gly Ala Pro Asn Ser Ser Pro Ile His Leu Asn Arg Thr Pro 
            260                 265                 270         


Leu Ser Pro Pro Ser Val Met Leu His Gly Ser Pro Val Gln Ser Ser 
        275                 280                 285             


Cys Ala Met Ala Gly Arg Thr Asn Ile Pro Leu Ser Pro Thr Leu Thr 
    290                 295                 300                 


Thr Lys Ser Pro Val Met Lys Lys Pro Met Cys Asn Phe Ser Thr Asn 
305                 310                 315                 320 


Met Glu Ile Pro Arg Ala Met Phe His His Lys Pro Pro Gln Gly Pro 
                325                 330                 335     


Pro Pro Pro Pro Pro Pro Ser Cys Ala Leu Gln Lys Lys Pro Leu Thr 
            340                 345                 350         


Ser Glu Lys Asp Pro Leu Gly Ile Leu Asp Pro Ile Pro Ser Lys Pro 
        355                 360                 365             


Val Asn Gln Asn Pro Val Ile Ile Asn Pro Thr Ser Phe His Ser Asn 
    370                 375                 380                 


Val His Ser Gln Val Pro Met Met Asn Val Ser Met Pro Pro Ala Val 
385                 390                 395                 400 


Val Pro Leu Pro Ser Asn Leu Pro Leu Pro Thr Val Lys Pro Gly His 
                405                 410                 415     


Met Asn His Gly Ser His Val Gln Arg Val Gln His Ser Ala Ser Thr 
            420                 425                 430         


Ser Leu Ser Pro Ser Pro Val Thr Ser Pro Val His Met Met Gly Thr 
        435                 440                 445             


Gly Ile Gly Arg Ile Glu Ala Ser Pro Gln Arg Ser Arg Ser Ser Ser 
    450                 455                 460                 


Thr Ser Ser Asp His Gly Asn Phe Met Met Pro Pro Val Gly Pro Gln 
465                 470                 475                 480 


Ala Thr Ser Ser Gly Ile Lys Val Pro Pro Arg Ser Pro Arg Ser Thr 
                485                 490                 495     


Ile Gly Ser Pro Arg Pro Ser Met Pro Ser Ser Pro Ser Thr Lys Ser 
            500                 505                 510         


Asp Gly His His Gln Tyr Lys Asp Ile Pro Asn Pro Leu Ile Ala Gly 
        515                 520                 525             


Ile Ser Asn Val Leu Asn Thr Pro Ser Ser Ala Ala Phe Pro Thr Ala 
    530                 535                 540                 


Ser Ala Gly Ser Ser Ser Val Lys Ser Gln Pro Gly Leu Leu Gly Met 
545                 550                 555                 560 


Pro Leu Asn Gln Ile Leu Asn Gln His Asn Ala Ala Ser Phe Pro Ala 
                565                 570                 575     


Ser Ser Leu Leu Ser Ala Ala Ala Lys Ala Gln Leu Ala Asn Gln Asn 
            580                 585                 590         


Lys Leu Ala Gly Asn Asn Ser Ser Ser Ser Ser Asn Ser Gly Ala Val 
        595                 600                 605             


Ala Gly Ser Gly Asn Thr Glu Gly His Ser Thr Leu Asn Thr Met Phe 
    610                 615                 620                 


Pro Pro Thr Ala Asn Met Leu Leu Pro Thr Gly Glu Gly Gln Ser Gly 
625                 630                 635                 640 


Arg Ala Ala Leu Arg Asp Lys Leu Met Ser Gln Gln Lys Asp Ala Leu 
                645                 650                 655     


Arg Lys Arg Lys Gln Pro Pro Thr Thr Val Leu Ser Leu Leu Arg Gln 
            660                 665                 670         


Ser Gln Met Asp Ser Ser Ala Val Pro Lys Pro Gly Pro Asp Leu Leu 
        675                 680                 685             


Arg Lys Gln Gly Gln Gly Ser Phe Pro Ile Ser Ser Met Ser Gln Leu 
    690                 695                 700                 


Leu Gln Ser Met Ser Cys Gln Ser Ser His Leu Ser Ser Asn Ser Thr 
705                 710                 715                 720 


Pro Gly Cys Gly Ala Ser Asn Thr Ala Leu Pro Cys Ser Ala Asn Gln 
                725                 730                 735     


Leu His Phe Thr Asp Pro Ser Met Asn Ser Ser Val Leu Gln Asn Ile 
            740                 745                 750         


Pro Leu Arg Gly Glu Ala Val His Cys His Asn Ala Asn Thr Asn Phe 
        755                 760                 765             


Val His Ser Asn Ser Pro Val Pro Asn His His Leu Ala Gly Leu Ile 
    770                 775                 780                 


Asn Gln Ile Gln Ala Ser Gly Asn Cys Gly Met Leu Ser Gln Ser Gly 
785                 790                 795                 800 


Met Ala Leu Gly Asn Ser Leu His Pro Asn Pro Pro Gln Ser Arg Ile 
                805                 810                 815     


Ser Thr Ser Ser Thr Pro Val Ile Pro Asn Ser Ile Val Ser Ser Tyr 
            820                 825                 830         


Asn Gln Thr Ser Ser Glu Ala Gly Gly Ser Gly Pro Ser Ser Ser Ile 
        835                 840                 845             


Ala Ile Ala Gly Thr Asn His Pro Ala Ile Thr Lys Thr Thr Ser Val 
    850                 855                 860                 


Leu Gln Asp Gly Val Ile Val Thr Thr Ala Ala Gly Asn Pro Leu Gln 
865                 870                 875                 880 


Ser Gln Leu Pro Ile Gly Ser Asp Phe Pro Phe Val Gly Gln Glu His 
                885                 890                 895     


Ala Leu His Phe Pro Ser Asn Ser Thr Ser Asn Asn His Leu Pro His 
            900                 905                 910         


Pro Leu Asn Pro Ser Leu Leu Ser Ser Leu Pro Ile Ser Leu Pro Val 
        915                 920                 925             


Asn Gln Gln His Leu Leu Asn Gln Asn Leu Leu Asn Ile Leu Gln Pro 
    930                 935                 940                 


Ser Ala Gly Glu Gly Asp Met Ser Ser Ile Asn Asn Thr Leu Ser Asn 
945                 950                 955                 960 


His Gln Leu Thr His Leu Gln Ser Leu Leu Asn Asn Asn Gln Met Phe 
                965                 970                 975     


Pro Pro Asn Gln Gln Gln Gln Gln Leu Leu Gln Gly Tyr Gln Asn Leu 
            980                 985                 990         


Gln Ala Phe Gln Gly Gln Ser Thr  Ile Pro Cys Pro Ala  Asn Asn Asn 
        995                 1000                 1005             


Pro Met  Ala Cys Leu Phe Gln  Asn Phe Gln Val Arg  Met Gln Glu 
    1010                 1015                 1020             


Asp Ala  Ala Leu Leu Asn Lys  Arg Ile Ser Thr Gln  Pro Gly Leu 
    1025                 1030                 1035             


Thr Ala  Leu Pro Glu Asn Pro  Asn Thr Thr Leu Pro  Pro Phe Gln 
    1040                 1045                 1050             


Asp Thr  Pro Cys Glu Leu Gln  Pro Arg Ile Asp Pro  Ser Leu Gly 
    1055                 1060                 1065             


Gln Gln  Val Lys Asp Gly Leu  Val Val Gly Gly Pro  Gly Asp Ala 
    1070                 1075                 1080             


Ser Val  Asp Ala Ile Tyr Lys  Ala Val Val Asp Ala  Ala Ser Lys 
    1085                 1090                 1095             


Gly Met  Gln Val Val Ile Thr  Thr Ala Val Asn Ser  Thr Thr Gln 
    1100                 1105                 1110             


Ile Ser  Pro Ile Pro Ala Leu  Ser Ala Met Ser Ala  Phe Thr Ala 
    1115                 1120                 1125             


Ser Ile  Gly Asp Pro Leu Asn  Leu Ser Ser Ala Val  Ser Ala Val 
    1130                 1135                 1140             


Ile His  Gly Arg Asn Met Gly  Gly Val Asp His Asp  Gly Arg Leu 
    1145                 1150                 1155             


Arg Asn  Ser Arg Gly Ala Arg  Leu Pro Lys Asn Leu  Asp His Gly 
    1160                 1165                 1170             


Lys Asn  Val Asn Glu Gly Asp  Gly Phe Glu Tyr Phe  Lys Ser Ala 
    1175                 1180                 1185             


Ser Cys  His Thr Ser Lys Lys  Gln Trp Asp Gly Glu  Gln Ser Pro 
    1190                 1195                 1200             


Arg Gly  Glu Arg Asn Arg Trp  Lys Tyr Glu Glu Phe  Leu Asp His 
    1205                 1210                 1215             


Pro Gly  His Ile His Ser Ser  Pro Cys His Glu Arg  Pro Asn Asn 
    1220                 1225                 1230             


Val Ser  Thr Leu Pro Phe Leu  Pro Gly Glu Gln His  Pro Ile Leu 
    1235                 1240                 1245             


Leu Pro  Pro Arg Asn Cys Pro  Gly Asp Lys Ile Leu  Glu Glu Asn 
    1250                 1255                 1260             


Phe Arg  Tyr Asn Asn Tyr Lys  Arg Thr Met Met Ser  Phe Lys Glu 
    1265                 1270                 1275             


Arg Leu  Glu Asn Thr Val Glu  Arg Cys Ala His Ile  Asn Gly Asn 
    1280                 1285                 1290             


Arg Pro  Arg Gln Ser Arg Gly  Phe Gly Glu Leu Leu  Ser Thr Ala 
    1295                 1300                 1305             


Lys Gln  Asp Leu Val Leu Glu  Glu Gln Ser Pro Ser  Ser Ser Asn 
    1310                 1315                 1320             


Ser Leu  Glu Asn Ser Leu Val  Lys Asp Tyr Ile His  Tyr Asn Gly 
    1325                 1330                 1335             


Asp Phe  Asn Ala Lys Ser Val  Asn Gly Cys Val Pro  Ser Pro Ser 
    1340                 1345                 1350             


Asp Ala  Lys Ser Ile Ser Ser  Glu Asp Asp Leu Arg  Asn Pro Asp 
    1355                 1360                 1365             


Ser Pro  Ser Ser Asn Glu Leu  Ile His Tyr Arg Pro  Arg Thr Phe 
    1370                 1375                 1380             


Asn Val  Gly Asp Leu Val Trp  Gly Gln Ile Lys Gly  Leu Thr Ser 
    1385                 1390                 1395             


Trp Pro  Gly Lys Leu Val Arg  Glu Asp Asp Val His  Asn Ser Cys 
    1400                 1405                 1410             


Gln Gln  Ser Pro Glu Glu Gly  Lys Val Glu Pro Glu  Lys Leu Lys 
    1415                 1420                 1425             


Thr Leu  Thr Glu Gly Leu Glu  Ala Tyr Ser Arg Val  Arg Lys Arg 
    1430                 1435                 1440             


Asn Arg  Lys Ser Gly Lys Leu  Asn Asn His Leu Glu  Ala Ala Ile 
    1445                 1450                 1455             


His Glu  Ala Met Ser Glu Leu  Asp Lys Met Ser Gly  Thr Val His 
    1460                 1465                 1470             


Gln Ile  Pro Gln Gly Asp Arg  Gln Met Arg Pro Pro  Lys Pro Lys 
    1475                 1480                 1485             


Arg Arg  Lys Ile Ser Arg 
    1490                 


<210>  811
<211>  2461
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (173)..(1099)

<400>  811
gcgcgcagtt tcccgcatgc tcagtagctg aggtagggat gccatccttc tcaaaagact       60

tattgacagt gccaaagctc ggtactggac acaacgaggg acctgggtct acgataacgc      120

gcttttgctc ctcctgaagt gtctttggtc caacgttgtt ccagagtgta cc atg gct      178
                                                          Met Ala         
                                                          1               

tcc agt aac act gtg ttg atg cgg ttg gta gcc tcc gca tat tct att        226
Ser Ser Asn Thr Val Leu Met Arg Leu Val Ala Ser Ala Tyr Ser Ile           
        5                   10                  15                        

gct caa aag gca gga atg ata gtc aga cgt gtt att gct gaa gga gac        274
Ala Gln Lys Ala Gly Met Ile Val Arg Arg Val Ile Ala Glu Gly Asp           
    20                  25                  30                            

ctg ggt att gtg gag aag acc tgt gca aca gac ctg cag acc aaa gct        322
Leu Gly Ile Val Glu Lys Thr Cys Ala Thr Asp Leu Gln Thr Lys Ala           
35                  40                  45                  50            

gac cga ttg gca cag atg agc ata tgt tct tca ttg gcc cgg aaa ttc        370
Asp Arg Leu Ala Gln Met Ser Ile Cys Ser Ser Leu Ala Arg Lys Phe           
                55                  60                  65                

ccc aaa ctc aca att ata ggg gaa gag gat ctg cct tct gag gaa gtg        418
Pro Lys Leu Thr Ile Ile Gly Glu Glu Asp Leu Pro Ser Glu Glu Val           
            70                  75                  80                    

gat caa gag ctg att gaa gac agt cag tgg gaa gaa ata ctg aag caa        466
Asp Gln Glu Leu Ile Glu Asp Ser Gln Trp Glu Glu Ile Leu Lys Gln           
        85                  90                  95                        

cca tgc cca tcg cag tac agt gct att aaa gaa gaa gat ctc gtg gtc        514
Pro Cys Pro Ser Gln Tyr Ser Ala Ile Lys Glu Glu Asp Leu Val Val           
    100                 105                 110                           

tgg gtt gat cct ctg gat gga acc aag gaa tat acc gaa ggt ctt ctt        562
Trp Val Asp Pro Leu Asp Gly Thr Lys Glu Tyr Thr Glu Gly Leu Leu           
115                 120                 125                 130           

gac aat gta aca gtt ctt att gga att gct tat gaa gga aaa gcc ata        610
Asp Asn Val Thr Val Leu Ile Gly Ile Ala Tyr Glu Gly Lys Ala Ile           
                135                 140                 145               

gca gga gtt att aac cag cca tat tac aac tat gag gca gga cca gat        658
Ala Gly Val Ile Asn Gln Pro Tyr Tyr Asn Tyr Glu Ala Gly Pro Asp           
            150                 155                 160                   

gct gtg ttg ggg agg aca atc tgg gga gtt tta ggt tta ggc gcc ttt        706
Ala Val Leu Gly Arg Thr Ile Trp Gly Val Leu Gly Leu Gly Ala Phe           
        165                 170                 175                       

ggg ttt cag ctg aaa gaa gtc cct gct ggg aaa cac att atc aca act        754
Gly Phe Gln Leu Lys Glu Val Pro Ala Gly Lys His Ile Ile Thr Thr           
    180                 185                 190                           

act cga tcc cat agc aac aag ttg gtt act gac tgt gtt gct gct atg        802
Thr Arg Ser His Ser Asn Lys Leu Val Thr Asp Cys Val Ala Ala Met           
195                 200                 205                 210           

aac ccc gat gct gtg ctg cga gta gga gga gca gga aat aag att att        850
Asn Pro Asp Ala Val Leu Arg Val Gly Gly Ala Gly Asn Lys Ile Ile           
                215                 220                 225               

cag ctg att gaa ggc aaa gcc tct gct tat gta ttt gca agt cct ggt        898
Gln Leu Ile Glu Gly Lys Ala Ser Ala Tyr Val Phe Ala Ser Pro Gly           
            230                 235                 240                   

tgt aag aag tgg gat act tgt gct cca gaa gtt att tta cat gct gtg        946
Cys Lys Lys Trp Asp Thr Cys Ala Pro Glu Val Ile Leu His Ala Val           
        245                 250                 255                       

gga ggc aag tta acc gat atc cat ggg aat gtt ctt cag tac cac aag        994
Gly Gly Lys Leu Thr Asp Ile His Gly Asn Val Leu Gln Tyr His Lys           
    260                 265                 270                           

gat gtg aag cat atg aac tct gca gga gtc ctg gcc aca ctg agg aat       1042
Asp Val Lys His Met Asn Ser Ala Gly Val Leu Ala Thr Leu Arg Asn           
275                 280                 285                 290           

tat gac tac tat gca agc cga gtt cca gaa tct att aaa aat gca ctt       1090
Tyr Asp Tyr Tyr Ala Ser Arg Val Pro Glu Ser Ile Lys Asn Ala Leu           
                295                 300                 305               

gtt cct taa aggaaagttt catttggccg ggcgcggtgg ctcatgcctg               1139
Val Pro                                                                   
                                                                          

taatcccagc actttgggag gccgaggcag gtggatcact tgagctcagg agtttgagac     1199

cagcctgggc aatatcgtga gaccccatct ctacaaaaat acaaattaac tgggcatcct     1259

gtcatgcgcc tgtcatccca gctacttgag aggctgaagc agaagaatct cttgagcccg     1319

gaaggcagag gttgcagtga gctgagatcg tgccactgca ctccagcctg agtgacagga     1379

gttaagccct gtctcagaaa aaaaaaaaac aaaaacccaa aaagtactta aagtttcatt     1439

tacttagcta ggagaaagac ttggttctca aaataataca ttttaagatt aattgggtag     1499

aattagagtt ccacctttat tcattgttga gcagtgattt atatttagtt attatattta     1559

ggaatagaaa atagaattaa ataatttaac ttgattaatc aaccagacca attttgacgt     1619

ctggagaact tataaactca atatgttata tttgttttcc tgtatttagg tggagaaatg     1679

agaaaaagct ttagttccaa ttgacagttc aggtcaatgt tcaatgaaca ttcctatctt     1739

ctaaaccaga tttctctttt tttttcctga gacggagtct cgctctgtag cctaggctag     1799

aatgtagtgg cgtgatctcg gctcactgca agctccgcct cccgggttca tgccattctc     1859

ctgcctcagc ctcccgagta gctgggactg caggcaccgc caccacgcct ggctaatttt     1919

ttgtattttt agtagagaag gtgtttcacc gtgttagcca ggatggtctt gatctcctga     1979

catcgtgatc tgtctgcctc ggactcccaa agtgctggga ttacaggtgt gagccaccgc     2039

acctggccta aaccagattt ctttagggca caattttttc tggaatctca ctcttgtttt     2099

tcacagtaat tttaaaaacg tttctactcc aattaagaat atatatgatg ttattatata     2159

tgcttatgaa acagatttat gagaaaagtt ttttttaaat aaattattta atcctagctc     2219

tttgttattc accagctttt taaaaaagtg tttgaaaatt atacattctc gactttgggg     2279

attagtttat tcttgtggca tcattataag gcttaattgt ggaaagctaa gtacttgctt     2339

ctattccttc caatgagaga ttataacata aactattaaa attattctgc taatatacct     2399

agatttttat ttttaggtct ctgtccattg cttttaatta aaattatctg ttttcaaatc     2459

aa                                                                    2461


<210>  812
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  812

Met Ala Ser Ser Asn Thr Val Leu Met Arg Leu Val Ala Ser Ala Tyr 
1               5                   10                  15      


Ser Ile Ala Gln Lys Ala Gly Met Ile Val Arg Arg Val Ile Ala Glu 
            20                  25                  30          


Gly Asp Leu Gly Ile Val Glu Lys Thr Cys Ala Thr Asp Leu Gln Thr 
        35                  40                  45              


Lys Ala Asp Arg Leu Ala Gln Met Ser Ile Cys Ser Ser Leu Ala Arg 
    50                  55                  60                  


Lys Phe Pro Lys Leu Thr Ile Ile Gly Glu Glu Asp Leu Pro Ser Glu 
65                  70                  75                  80  


Glu Val Asp Gln Glu Leu Ile Glu Asp Ser Gln Trp Glu Glu Ile Leu 
                85                  90                  95      


Lys Gln Pro Cys Pro Ser Gln Tyr Ser Ala Ile Lys Glu Glu Asp Leu 
            100                 105                 110         


Val Val Trp Val Asp Pro Leu Asp Gly Thr Lys Glu Tyr Thr Glu Gly 
        115                 120                 125             


Leu Leu Asp Asn Val Thr Val Leu Ile Gly Ile Ala Tyr Glu Gly Lys 
    130                 135                 140                 


Ala Ile Ala Gly Val Ile Asn Gln Pro Tyr Tyr Asn Tyr Glu Ala Gly 
145                 150                 155                 160 


Pro Asp Ala Val Leu Gly Arg Thr Ile Trp Gly Val Leu Gly Leu Gly 
                165                 170                 175     


Ala Phe Gly Phe Gln Leu Lys Glu Val Pro Ala Gly Lys His Ile Ile 
            180                 185                 190         


Thr Thr Thr Arg Ser His Ser Asn Lys Leu Val Thr Asp Cys Val Ala 
        195                 200                 205             


Ala Met Asn Pro Asp Ala Val Leu Arg Val Gly Gly Ala Gly Asn Lys 
    210                 215                 220                 


Ile Ile Gln Leu Ile Glu Gly Lys Ala Ser Ala Tyr Val Phe Ala Ser 
225                 230                 235                 240 


Pro Gly Cys Lys Lys Trp Asp Thr Cys Ala Pro Glu Val Ile Leu His 
                245                 250                 255     


Ala Val Gly Gly Lys Leu Thr Asp Ile His Gly Asn Val Leu Gln Tyr 
            260                 265                 270         


His Lys Asp Val Lys His Met Asn Ser Ala Gly Val Leu Ala Thr Leu 
        275                 280                 285             


Arg Asn Tyr Asp Tyr Tyr Ala Ser Arg Val Pro Glu Ser Ile Lys Asn 
    290                 295                 300                 


Ala Leu Val Pro 
305             


<210>  813
<211>  2341
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (94)..(1665)

<400>  813
agtgcctttg gcgcactgag gtgcacaggg tcccttagcc gggcgcaggg cgcgcagccc       60

aggctgagat ccgcggcttc cgtagaagtg agc atg gct ggg cag cga gtg ctt       114
                                     Met Ala Gly Gln Arg Val Leu          
                                     1               5                    

ctt cta gtg ggc ttc ctt ctc cct ggg gtc ctg ctc tca gag gct gcc        162
Leu Leu Val Gly Phe Leu Leu Pro Gly Val Leu Leu Ser Glu Ala Ala           
        10                  15                  20                        

aaa atc ctg aca ata tct aca gta ggt gga agc cat tat cta ctg atg        210
Lys Ile Leu Thr Ile Ser Thr Val Gly Gly Ser His Tyr Leu Leu Met           
    25                  30                  35                            

gac cgg gtt tct cag att ctt caa gat cac ggt cat aat gtc acc atg        258
Asp Arg Val Ser Gln Ile Leu Gln Asp His Gly His Asn Val Thr Met           
40                  45                  50                  55            

ctt aac cac aaa aga ggt cct ttt atg cca gat ttt aaa aag gaa gaa        306
Leu Asn His Lys Arg Gly Pro Phe Met Pro Asp Phe Lys Lys Glu Glu           
                60                  65                  70                

aaa tca tat caa gtt atc agt tgg ctt gca cct gaa gat cat caa aga        354
Lys Ser Tyr Gln Val Ile Ser Trp Leu Ala Pro Glu Asp His Gln Arg           
            75                  80                  85                    

gaa ttt aaa aag agt ttt gat ttc ttt ctg gaa gaa act tta ggt ggc        402
Glu Phe Lys Lys Ser Phe Asp Phe Phe Leu Glu Glu Thr Leu Gly Gly           
        90                  95                  100                       

aga gga aaa ttt gaa aac tta tta aat gtt cta gaa tac ttg gcg ttg        450
Arg Gly Lys Phe Glu Asn Leu Leu Asn Val Leu Glu Tyr Leu Ala Leu           
    105                 110                 115                           

cag tgc agt cat ttt tta aat aga aag gat atc atg gat tcc tta aag        498
Gln Cys Ser His Phe Leu Asn Arg Lys Asp Ile Met Asp Ser Leu Lys           
120                 125                 130                 135           

aat gag aac ttc gac atg gtg ata gtt gaa act ttt gac tac tgt cct        546
Asn Glu Asn Phe Asp Met Val Ile Val Glu Thr Phe Asp Tyr Cys Pro           
                140                 145                 150               

ttc ctg att gct gag aag ctt ggg aag cca ttt gtg gcc att ctt tcc        594
Phe Leu Ile Ala Glu Lys Leu Gly Lys Pro Phe Val Ala Ile Leu Ser           
            155                 160                 165                   

act tca ttc ggc tct ttg gaa ttt ggg cta cca atc ccc ttg tct tat        642
Thr Ser Phe Gly Ser Leu Glu Phe Gly Leu Pro Ile Pro Leu Ser Tyr           
        170                 175                 180                       

gtt cca gta ttc cgt tcc ttg ctg act gat cac atg gac ttc tgg ggc        690
Val Pro Val Phe Arg Ser Leu Leu Thr Asp His Met Asp Phe Trp Gly           
    185                 190                 195                           

cga gtg aag aat ttt ctg atg ttc ttt agt ttc tgc agg agg caa cag        738
Arg Val Lys Asn Phe Leu Met Phe Phe Ser Phe Cys Arg Arg Gln Gln           
200                 205                 210                 215           

cac atg cag tct aca ttt gac aac acc atc aag gaa cat ttc aca gaa        786
His Met Gln Ser Thr Phe Asp Asn Thr Ile Lys Glu His Phe Thr Glu           
                220                 225                 230               

ggc tct agg cca gtt ttg tct cat ctt cta ctg aaa gca gag ttg tgg        834
Gly Ser Arg Pro Val Leu Ser His Leu Leu Leu Lys Ala Glu Leu Trp           
            235                 240                 245                   

ttc att aac tct gac ttt gcc ttt gat ttt gct cga cct ctg ctt ccc        882
Phe Ile Asn Ser Asp Phe Ala Phe Asp Phe Ala Arg Pro Leu Leu Pro           
        250                 255                 260                       

aac act gtt tat gtt gga ggc ttg atg gaa aaa cct att aaa cca gta        930
Asn Thr Val Tyr Val Gly Gly Leu Met Glu Lys Pro Ile Lys Pro Val           
    265                 270                 275                           

cca caa gac ttg gag aac ttc att gcc aag ttt gag gac tct ggt ttt        978
Pro Gln Asp Leu Glu Asn Phe Ile Ala Lys Phe Glu Asp Ser Gly Phe           
280                 285                 290                 295           

gtc ctt gtg acc ttg ggc tcc atg gtg aac acc tgt cag aat ccg gaa       1026
Val Leu Val Thr Leu Gly Ser Met Val Asn Thr Cys Gln Asn Pro Glu           
                300                 305                 310               

atc ttc aag gag atg aac aat gcc ttt gct cac cta ccc caa ggg gtg       1074
Ile Phe Lys Glu Met Asn Asn Ala Phe Ala His Leu Pro Gln Gly Val           
            315                 320                 325                   

ata tgg aag tgt cag tgt tct cat tgg ccc aaa gat gtc cac ctg gct       1122
Ile Trp Lys Cys Gln Cys Ser His Trp Pro Lys Asp Val His Leu Ala           
        330                 335                 340                       

gca aat gtg aaa att gtg gac tgg ctt cct cag agt gac ctc ctg gct       1170
Ala Asn Val Lys Ile Val Asp Trp Leu Pro Gln Ser Asp Leu Leu Ala           
    345                 350                 355                           

cac cca agc atc cgt ctg ttt gtc acc cac ggc ggg cag aat agc ata       1218
His Pro Ser Ile Arg Leu Phe Val Thr His Gly Gly Gln Asn Ser Ile           
360                 365                 370                 375           

atg gag gcc atc cag cat ggt gtg ccc atg gtg ggg atc cct ctc ttt       1266
Met Glu Ala Ile Gln His Gly Val Pro Met Val Gly Ile Pro Leu Phe           
                380                 385                 390               

gga gac cag cct gaa aac atg gtc cga gta gaa gcc aaa aag ttt ggt       1314
Gly Asp Gln Pro Glu Asn Met Val Arg Val Glu Ala Lys Lys Phe Gly           
            395                 400                 405                   

gtt tct att cag tta aag aag ctc aag gca gag aca ttg gct ctt aag       1362
Val Ser Ile Gln Leu Lys Lys Leu Lys Ala Glu Thr Leu Ala Leu Lys           
        410                 415                 420                       

atg aaa caa atc atg gaa gac aag aga tac aag tcc gcg gca gtg gct       1410
Met Lys Gln Ile Met Glu Asp Lys Arg Tyr Lys Ser Ala Ala Val Ala           
    425                 430                 435                           

gcc agt gtc atc ctg cgc tcc cac ccg ctc agc ccc aca cag cgg ctg       1458
Ala Ser Val Ile Leu Arg Ser His Pro Leu Ser Pro Thr Gln Arg Leu           
440                 445                 450                 455           

gtg ggc tgg att gac cac gtc ctc cag aca ggg ggc gcg acg cac ctc       1506
Val Gly Trp Ile Asp His Val Leu Gln Thr Gly Gly Ala Thr His Leu           
                460                 465                 470               

aag ccc tat gtc ttt cag cag ccc tgg cat gag cag tac ctg ctc gac       1554
Lys Pro Tyr Val Phe Gln Gln Pro Trp His Glu Gln Tyr Leu Leu Asp           
            475                 480                 485                   

gtt ttt gtg ttt ctg ctg ggg ctc act ctg ggg act cta tgg ctt tgt       1602
Val Phe Val Phe Leu Leu Gly Leu Thr Leu Gly Thr Leu Trp Leu Cys           
        490                 495                 500                       

ggg aag ctg ctg ggc atg gct gtc tgg tgg ctg cgt ggg gcc aga aag       1650
Gly Lys Leu Leu Gly Met Ala Val Trp Trp Leu Arg Gly Ala Arg Lys           
    505                 510                 515                           

gtg aag gag aca taa ggccaggtgc agccttggcg gggtctgttt ggtgggcgat       1705
Val Lys Glu Thr                                                           
520                                                                       

gtcaccattt ctagggagct tcccactagt tctggcagcc ccattctcta gtccttctag     1765

ttatctcctg ttttcttgaa gaacaggaaa aatggccaaa aatcatcctt tccacttgct     1825

aattttgcta caaattcatc cttactagct cctgcctgct agcagaattc tttccagtcc     1885

tcttgtcctc ctttgtttgc catcagcaag ggctatgctg tgattctgtc tctgagtgac     1945

ttggaccact gaccctcaga tttccagcct taaaatccac cttccttctc atgcgcctct     2005

ccgaatcaca ccctgactct tccagcctcc atgtccagac ctagtcagcc tctctcactc     2065

ctgcccctac tatctatcat ggaataacat ccaagaaaga caccttgcat attctttcag     2125

tttctgtttt gttctcccac atattctctt caatgctcag gaagcctgcc ctgtgcttga     2185

gagttcaggg ccggacacag gctcacaggt ctccacattg ggtccctgtc tctggtgccc     2245

acagtgagct ccttcttggc tgagcaggca tggagactgt aggtttccag atttcctgaa     2305

aaataaaagt ttacagcgtt atctctcccc aacctc                               2341


<210>  814
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  814

Met Ala Gly Gln Arg Val Leu Leu Leu Val Gly Phe Leu Leu Pro Gly 
1               5                   10                  15      


Val Leu Leu Ser Glu Ala Ala Lys Ile Leu Thr Ile Ser Thr Val Gly 
            20                  25                  30          


Gly Ser His Tyr Leu Leu Met Asp Arg Val Ser Gln Ile Leu Gln Asp 
        35                  40                  45              


His Gly His Asn Val Thr Met Leu Asn His Lys Arg Gly Pro Phe Met 
    50                  55                  60                  


Pro Asp Phe Lys Lys Glu Glu Lys Ser Tyr Gln Val Ile Ser Trp Leu 
65                  70                  75                  80  


Ala Pro Glu Asp His Gln Arg Glu Phe Lys Lys Ser Phe Asp Phe Phe 
                85                  90                  95      


Leu Glu Glu Thr Leu Gly Gly Arg Gly Lys Phe Glu Asn Leu Leu Asn 
            100                 105                 110         


Val Leu Glu Tyr Leu Ala Leu Gln Cys Ser His Phe Leu Asn Arg Lys 
        115                 120                 125             


Asp Ile Met Asp Ser Leu Lys Asn Glu Asn Phe Asp Met Val Ile Val 
    130                 135                 140                 


Glu Thr Phe Asp Tyr Cys Pro Phe Leu Ile Ala Glu Lys Leu Gly Lys 
145                 150                 155                 160 


Pro Phe Val Ala Ile Leu Ser Thr Ser Phe Gly Ser Leu Glu Phe Gly 
                165                 170                 175     


Leu Pro Ile Pro Leu Ser Tyr Val Pro Val Phe Arg Ser Leu Leu Thr 
            180                 185                 190         


Asp His Met Asp Phe Trp Gly Arg Val Lys Asn Phe Leu Met Phe Phe 
        195                 200                 205             


Ser Phe Cys Arg Arg Gln Gln His Met Gln Ser Thr Phe Asp Asn Thr 
    210                 215                 220                 


Ile Lys Glu His Phe Thr Glu Gly Ser Arg Pro Val Leu Ser His Leu 
225                 230                 235                 240 


Leu Leu Lys Ala Glu Leu Trp Phe Ile Asn Ser Asp Phe Ala Phe Asp 
                245                 250                 255     


Phe Ala Arg Pro Leu Leu Pro Asn Thr Val Tyr Val Gly Gly Leu Met 
            260                 265                 270         


Glu Lys Pro Ile Lys Pro Val Pro Gln Asp Leu Glu Asn Phe Ile Ala 
        275                 280                 285             


Lys Phe Glu Asp Ser Gly Phe Val Leu Val Thr Leu Gly Ser Met Val 
    290                 295                 300                 


Asn Thr Cys Gln Asn Pro Glu Ile Phe Lys Glu Met Asn Asn Ala Phe 
305                 310                 315                 320 


Ala His Leu Pro Gln Gly Val Ile Trp Lys Cys Gln Cys Ser His Trp 
                325                 330                 335     


Pro Lys Asp Val His Leu Ala Ala Asn Val Lys Ile Val Asp Trp Leu 
            340                 345                 350         


Pro Gln Ser Asp Leu Leu Ala His Pro Ser Ile Arg Leu Phe Val Thr 
        355                 360                 365             


His Gly Gly Gln Asn Ser Ile Met Glu Ala Ile Gln His Gly Val Pro 
    370                 375                 380                 


Met Val Gly Ile Pro Leu Phe Gly Asp Gln Pro Glu Asn Met Val Arg 
385                 390                 395                 400 


Val Glu Ala Lys Lys Phe Gly Val Ser Ile Gln Leu Lys Lys Leu Lys 
                405                 410                 415     


Ala Glu Thr Leu Ala Leu Lys Met Lys Gln Ile Met Glu Asp Lys Arg 
            420                 425                 430         


Tyr Lys Ser Ala Ala Val Ala Ala Ser Val Ile Leu Arg Ser His Pro 
        435                 440                 445             


Leu Ser Pro Thr Gln Arg Leu Val Gly Trp Ile Asp His Val Leu Gln 
    450                 455                 460                 


Thr Gly Gly Ala Thr His Leu Lys Pro Tyr Val Phe Gln Gln Pro Trp 
465                 470                 475                 480 


His Glu Gln Tyr Leu Leu Asp Val Phe Val Phe Leu Leu Gly Leu Thr 
                485                 490                 495     


Leu Gly Thr Leu Trp Leu Cys Gly Lys Leu Leu Gly Met Ala Val Trp 
            500                 505                 510         


Trp Leu Arg Gly Ala Arg Lys Val Lys Glu Thr 
        515                 520             


<210>  815
<211>  846
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (77)..(703)

<400>  815
tgggccttcc cccaggaaga gccccacggc cagctccttc ctgttcccct ggcggcccct       60

cgcttcttcc ttctgg atg ggg gcc cag ggg gcc cag gag agt ata aag gcg      112
                  Met Gly Ala Gln Gly Ala Gln Glu Ser Ile Lys Ala         
                  1               5                   10                  

atg tgg agg gtg ccc ggc aca acc aga cgc cca gtc aca ggc gag agc        160
Met Trp Arg Val Pro Gly Thr Thr Arg Arg Pro Val Thr Gly Glu Ser           
        15                  20                  25                        

cct ggg atg cac cgg cca gag gcc atg ctg ctg ctg ctc acg ctt gcc        208
Pro Gly Met His Arg Pro Glu Ala Met Leu Leu Leu Leu Thr Leu Ala           
    30                  35                  40                            

ctc ctg ggg ggc ccc acc tgg gca ggg aag atg tat ggc cct gga gga        256
Leu Leu Gly Gly Pro Thr Trp Ala Gly Lys Met Tyr Gly Pro Gly Gly           
45                  50                  55                  60            

ggc aag tat ttc agc acc act gaa gac tac gac cat gaa atc aca ggg        304
Gly Lys Tyr Phe Ser Thr Thr Glu Asp Tyr Asp His Glu Ile Thr Gly           
                65                  70                  75                

ctg cgg gtg tct gta ggt ctt ctc ctg gtg aaa agt gtc cag gtg aaa        352
Leu Arg Val Ser Val Gly Leu Leu Leu Val Lys Ser Val Gln Val Lys           
            80                  85                  90                    

ctt gga gac tcc tgg gac gtg aaa ctg gga gcc tta ggt ggg aat acc        400
Leu Gly Asp Ser Trp Asp Val Lys Leu Gly Ala Leu Gly Gly Asn Thr           
        95                  100                 105                       

cag gaa gtc acc ctg cag cca ggc gaa tac atc aca aaa gtc ttt gtc        448
Gln Glu Val Thr Leu Gln Pro Gly Glu Tyr Ile Thr Lys Val Phe Val           
    110                 115                 120                           

gcc ttc caa gct ttc ctc cgg ggt atg gtc atg tac acc agc aag gac        496
Ala Phe Gln Ala Phe Leu Arg Gly Met Val Met Tyr Thr Ser Lys Asp           
125                 130                 135                 140           

cgc tat ttc tat ttt ggg aag ctt gat ggc cag atc tcc tct gcc tac        544
Arg Tyr Phe Tyr Phe Gly Lys Leu Asp Gly Gln Ile Ser Ser Ala Tyr           
                145                 150                 155               

ccc agc caa gag ggg cag gtg ctg gtg ggc atc tat ggc cag tat caa        592
Pro Ser Gln Glu Gly Gln Val Leu Val Gly Ile Tyr Gly Gln Tyr Gln           
            160                 165                 170                   

ctc ctt ggc atc aag agc att ggc ttt gaa tgg aat tat cca cta gag        640
Leu Leu Gly Ile Lys Ser Ile Gly Phe Glu Trp Asn Tyr Pro Leu Glu           
        175                 180                 185                       

gag ccg acc act gag cca cca gtt aat ctc aca tac tca gca aac tca        688
Glu Pro Thr Thr Glu Pro Pro Val Asn Leu Thr Tyr Ser Ala Asn Ser           
    190                 195                 200                           

ccc gtg ggt cgc tag ggtggggtat ggggccatcc gagctgaggc catctgggtg        743
Pro Val Gly Arg                                                           
205                                                                       

gtggtggctg atggtactgg agtaactgag tcgggacgct gaatctgaat ccaccaataa      803

ataaaggttc tgcagaatca gtgcaaaaaa aaaaaaaaaa aaa                        846


<210>  816
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  816

Met Gly Ala Gln Gly Ala Gln Glu Ser Ile Lys Ala Met Trp Arg Val 
1               5                   10                  15      


Pro Gly Thr Thr Arg Arg Pro Val Thr Gly Glu Ser Pro Gly Met His 
            20                  25                  30          


Arg Pro Glu Ala Met Leu Leu Leu Leu Thr Leu Ala Leu Leu Gly Gly 
        35                  40                  45              


Pro Thr Trp Ala Gly Lys Met Tyr Gly Pro Gly Gly Gly Lys Tyr Phe 
    50                  55                  60                  


Ser Thr Thr Glu Asp Tyr Asp His Glu Ile Thr Gly Leu Arg Val Ser 
65                  70                  75                  80  


Val Gly Leu Leu Leu Val Lys Ser Val Gln Val Lys Leu Gly Asp Ser 
                85                  90                  95      


Trp Asp Val Lys Leu Gly Ala Leu Gly Gly Asn Thr Gln Glu Val Thr 
            100                 105                 110         


Leu Gln Pro Gly Glu Tyr Ile Thr Lys Val Phe Val Ala Phe Gln Ala 
        115                 120                 125             


Phe Leu Arg Gly Met Val Met Tyr Thr Ser Lys Asp Arg Tyr Phe Tyr 
    130                 135                 140                 


Phe Gly Lys Leu Asp Gly Gln Ile Ser Ser Ala Tyr Pro Ser Gln Glu 
145                 150                 155                 160 


Gly Gln Val Leu Val Gly Ile Tyr Gly Gln Tyr Gln Leu Leu Gly Ile 
                165                 170                 175     


Lys Ser Ile Gly Phe Glu Trp Asn Tyr Pro Leu Glu Glu Pro Thr Thr 
            180                 185                 190         


Glu Pro Pro Val Asn Leu Thr Tyr Ser Ala Asn Ser Pro Val Gly Arg 
        195                 200                 205             


<210>  817
<211>  1837
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (112)..(663)

<400>  817
cgctgaggag actccggtca ctgtcctcgc cccgcctccc ccttccctcc ccttggggac       60

caccgggcgc cacgccgcga acgtaatagc tcttcaagtc tgcaataaaa a atg gcc       117
                                                         Met Ala          
                                                         1                

tcc aac aaa act aca ttg caa aaa atg gga aaa aaa cag aat gga aag        165
Ser Asn Lys Thr Thr Leu Gln Lys Met Gly Lys Lys Gln Asn Gly Lys           
        5                   10                  15                        

agt aaa aaa gtt gaa gag gca gag cct gaa gaa ttt gtc gtg gaa aaa        213
Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val Glu Lys           
    20                  25                  30                            

gta cta gat cga cgt gta gtg aat ggg aaa gtg gaa tat ttc ctg aag        261
Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe Leu Lys           
35                  40                  45                  50            

tgg aag gga ttt aca gat gct gac aat act tgg gaa cct gaa gaa aat        309
Trp Lys Gly Phe Thr Asp Ala Asp Asn Thr Trp Glu Pro Glu Glu Asn           
                55                  60                  65                

tta gat tgt cca gaa ttg att gaa gcg ttt ctt aac tct cag aaa gct        357
Leu Asp Cys Pro Glu Leu Ile Glu Ala Phe Leu Asn Ser Gln Lys Ala           
            70                  75                  80                    

ggc aaa gaa aaa gat ggt aca aaa aga aaa tct tta tct gac agt gaa        405
Gly Lys Glu Lys Asp Gly Thr Lys Arg Lys Ser Leu Ser Asp Ser Glu           
        85                  90                  95                        

tct gat gac agc aaa tca aag aag aaa aga gat gct gct gac aaa cca        453
Ser Asp Asp Ser Lys Ser Lys Lys Lys Arg Asp Ala Ala Asp Lys Pro           
    100                 105                 110                           

aga gga ttt gcc aga ggt ctt gat cct gaa aga ata att ggt gcc aca        501
Arg Gly Phe Ala Arg Gly Leu Asp Pro Glu Arg Ile Ile Gly Ala Thr           
115                 120                 125                 130           

gac agc agt gga gaa ttg atg ttt ctc atg aaa tgg aaa gat tca gat        549
Asp Ser Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asp Ser Asp           
                135                 140                 145               

gag gca gac ttg gtg ctg gcg aaa gag gca aat atg aag tgt cct caa        597
Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Met Lys Cys Pro Gln           
            150                 155                 160                   

att gta att gct ttt tat gaa gag aga cta act tgg cat tct tgt cca        645
Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ser Cys Pro           
        165                 170                 175                       

gaa gat gaa gct caa taa ttgttcacat tgttctttta tatatattta               693
Glu Asp Glu Ala Gln                                                       
    180                                                                   

tatatatata taaaaattgg gtcttagatt ttgatttact agtgtgacaa aataactaca      753

tcctaatgaa aatcaagttt gatatgtttg ttttgaaagt agcgttggaa gagttgttgg      813

gggttttttg catccatagc actggttact ttgaacaaat aaataaaagc tttctgtagt      873

tgcttccttt atcagaaaag aacatttgat accatggtat atcatttcct cttcattaaa      933

gaacagcttt tctaaatgtt gggggaaatg tccatagtca ttactcagtc aaaacttgtg      993

ttctcatgag cctaaggacc attctagatt tattacgtgt tttttgtgtg tgtgtgtgtg     1053

tgtgtgtgtg tgtgtatcca taaaatgcat atgtaaattt ttttttgttt ttaagcattc     1113

acccaaacaa aaaaatcaca ggtaaaccca tgtttctgag atgccattat tccaagcaaa     1173

ataagagata atcccttcaa gttaaattga aaattttcct gaaaccatac atttcaagtg     1233

aaataagtaa ttctagatag gacaatttaa attggataat tttaaagtgt ctataattgc     1293

agtggtttat ttgcaaaatt cctaaaagga aaaattttat cactgccatc acagcaggtt     1353

tcctcatcca gatgaggaaa ctagacaaat gctagtgtgt tttaactagc taaacaaaac     1413

taagttaaat gaacatttaa aagtttccct agcgggccat tccttagcaa aatgttggaa     1473

tccctgttgc tacattgact aaaaggtcat gatgaatgga atatgtaaga cttggctcat     1533

agaaacctaa tcagatggtt agaggtgttg gcagtttagg acctgctgtc ataaatgtgt     1593

gaacaacctt ttgtaaccta acctattgac ctgcatgttt tttctttacc ccaattcatt     1653

acatggaggc tcaatcttga gtttgcttta ctggttcagc aaaagccagg aagaacaact     1713

ttgtagtaat caaaatgtta tccaactgta tattgtttac tttattgtaa atactggtga     1773

acagtggtta ataaatagtt ttatattcct ttatgcaaaa aaaaaaaaaa aaaaaaaaaa     1833

aaaa                                                                  1837


<210>  818
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  818

Met Ala Ser Asn Lys Thr Thr Leu Gln Lys Met Gly Lys Lys Gln Asn 
1               5                   10                  15      


Gly Lys Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val 
            20                  25                  30          


Glu Lys Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe 
        35                  40                  45              


Leu Lys Trp Lys Gly Phe Thr Asp Ala Asp Asn Thr Trp Glu Pro Glu 
    50                  55                  60                  


Glu Asn Leu Asp Cys Pro Glu Leu Ile Glu Ala Phe Leu Asn Ser Gln 
65                  70                  75                  80  


Lys Ala Gly Lys Glu Lys Asp Gly Thr Lys Arg Lys Ser Leu Ser Asp 
                85                  90                  95      


Ser Glu Ser Asp Asp Ser Lys Ser Lys Lys Lys Arg Asp Ala Ala Asp 
            100                 105                 110         


Lys Pro Arg Gly Phe Ala Arg Gly Leu Asp Pro Glu Arg Ile Ile Gly 
        115                 120                 125             


Ala Thr Asp Ser Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Ser Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Met Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ser 
                165                 170                 175     


Cys Pro Glu Asp Glu Ala Gln 
            180             


<210>  819
<211>  5582
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (163)..(1452)

<400>  819
ggcgtggggg gagcagatgc cgctggctgc cagcgggacg ccggcgagca gagcgcagcc       60

gcgagggagg cgcgagggag gcgagccgga gcccgagcac tagcagcagc cggagtcggc      120

gtaaagcacc cgggcgcagc cggagccggt gccgcagctg cg atg gcc gtg gcc         174
                                               Met Ala Val Ala            
                                               1                          

gtg ggg aga ccg tct aat gaa gag ctt cga aac ttg tct ttg tct ggc        222
Val Gly Arg Pro Ser Asn Glu Glu Leu Arg Asn Leu Ser Leu Ser Gly           
5                   10                  15                  20            

cat gtg gga ttt gac agc ctc cct gac cag ctg gtc aac aag tct act        270
His Val Gly Phe Asp Ser Leu Pro Asp Gln Leu Val Asn Lys Ser Thr           
                25                  30                  35                

tct caa gga ttc tgt ttc aac atc ctt tgt gtt ggt gag aca ggc att        318
Ser Gln Gly Phe Cys Phe Asn Ile Leu Cys Val Gly Glu Thr Gly Ile           
            40                  45                  50                    

ggc aaa tcc acg tta atg gac act ttg ttc aac acc aaa ttt gaa agt        366
Gly Lys Ser Thr Leu Met Asp Thr Leu Phe Asn Thr Lys Phe Glu Ser           
        55                  60                  65                        

gac cca gct act cac aat gaa cca ggt gtt cgg tta aaa gcc aga agt        414
Asp Pro Ala Thr His Asn Glu Pro Gly Val Arg Leu Lys Ala Arg Ser           
    70                  75                  80                            

tat gag ctt cag gaa agc aat gta cgg ctg aag tta acc att gtt gac        462
Tyr Glu Leu Gln Glu Ser Asn Val Arg Leu Lys Leu Thr Ile Val Asp           
85                  90                  95                  100           

acc gtg gga ttt gga gac cag ata aat aaa gat gac agc tat aag ccg        510
Thr Val Gly Phe Gly Asp Gln Ile Asn Lys Asp Asp Ser Tyr Lys Pro           
                105                 110                 115               

ata gta gaa tat att gat gcc cag ttc gag gcc tac ctg caa gag gaa        558
Ile Val Glu Tyr Ile Asp Ala Gln Phe Glu Ala Tyr Leu Gln Glu Glu           
            120                 125                 130                   

ttg aag att aaa cgt tct ctc ttc aac tac cat gac acg agg atc cat        606
Leu Lys Ile Lys Arg Ser Leu Phe Asn Tyr His Asp Thr Arg Ile His           
        135                 140                 145                       

gcc tgc ctc tac ttt att gcc cct act gga cat tca cta aag tcc ctg        654
Ala Cys Leu Tyr Phe Ile Ala Pro Thr Gly His Ser Leu Lys Ser Leu           
    150                 155                 160                           

gat ctg gtc acc atg aaa aag ctg gac agt aag gtg aac atc att cca        702
Asp Leu Val Thr Met Lys Lys Leu Asp Ser Lys Val Asn Ile Ile Pro           
165                 170                 175                 180           

ata att gca aaa gct gac acc att gcc aag aat gaa ctg cac aaa ttc        750
Ile Ile Ala Lys Ala Asp Thr Ile Ala Lys Asn Glu Leu His Lys Phe           
                185                 190                 195               

aag agt aag atc atg agt gaa ctg gtc agc aat ggg gtc cag ata tat        798
Lys Ser Lys Ile Met Ser Glu Leu Val Ser Asn Gly Val Gln Ile Tyr           
            200                 205                 210                   

cag ttt ccc act gat gaa gaa acg gtg gca gag att aac gca aca atg        846
Gln Phe Pro Thr Asp Glu Glu Thr Val Ala Glu Ile Asn Ala Thr Met           
        215                 220                 225                       

agt gtc cat ctc cca ttt gca gtg gtt ggc agc acc gaa gag gtg aag        894
Ser Val His Leu Pro Phe Ala Val Val Gly Ser Thr Glu Glu Val Lys           
    230                 235                 240                           

att ggc aac aag atg gca aag gcc agg cag tac ccc tgg ggt gtg gtg        942
Ile Gly Asn Lys Met Ala Lys Ala Arg Gln Tyr Pro Trp Gly Val Val           
245                 250                 255                 260           

cag gtt gag aat gaa aat cat tgc gat ttt gtg aaa ctt cga gag atg        990
Gln Val Glu Asn Glu Asn His Cys Asp Phe Val Lys Leu Arg Glu Met           
                265                 270                 275               

ctg atc cgc gtg aac atg gag gac ttg cga gag cag act cac acc cgc       1038
Leu Ile Arg Val Asn Met Glu Asp Leu Arg Glu Gln Thr His Thr Arg           
            280                 285                 290                   

cac tat gaa ttg tac cga cgc tgt aag ctt gaa gag atg ggg ttc aag       1086
His Tyr Glu Leu Tyr Arg Arg Cys Lys Leu Glu Glu Met Gly Phe Lys           
        295                 300                 305                       

gac act gac cct gac agc aaa ccc ttc agt ctt cag gag aca tat gaa       1134
Asp Thr Asp Pro Asp Ser Lys Pro Phe Ser Leu Gln Glu Thr Tyr Glu           
    310                 315                 320                           

gca aaa agg aat gaa ttc ctg gga gaa ctg cag aag aaa gaa gaa gaa       1182
Ala Lys Arg Asn Glu Phe Leu Gly Glu Leu Gln Lys Lys Glu Glu Glu           
325                 330                 335                 340           

atg aga caa atg ttt gtt atg aga gtg aag gag aaa gaa gct gaa ctt       1230
Met Arg Gln Met Phe Val Met Arg Val Lys Glu Lys Glu Ala Glu Leu           
                345                 350                 355               

aag gag gca gag aaa gag ctt cac gag aag ttt gac ctt cta aag cgg       1278
Lys Glu Ala Glu Lys Glu Leu His Glu Lys Phe Asp Leu Leu Lys Arg           
            360                 365                 370                   

aca cac caa gaa gaa aag aag aaa gtg gaa gac aag aag aag gag ctt       1326
Thr His Gln Glu Glu Lys Lys Lys Val Glu Asp Lys Lys Lys Glu Leu           
        375                 380                 385                       

gag gag gag gtg aac aac ttc cag aag aag aaa gca gcg gct cag tta       1374
Glu Glu Glu Val Asn Asn Phe Gln Lys Lys Lys Ala Ala Ala Gln Leu           
    390                 395                 400                           

cta cag tcc cag gcc cag caa tct ggg gcc cag caa acc aag aaa gac       1422
Leu Gln Ser Gln Ala Gln Gln Ser Gly Ala Gln Gln Thr Lys Lys Asp           
405                 410                 415                 420           

aag gat aag aaa aat gca agc ttc aca taa agcctggcaa gccaaggatg         1472
Lys Asp Lys Lys Asn Ala Ser Phe Thr                                       
                425                                                       

ttcccgcatt cacctgcttt tgcagtaata tcgtatctct gccatgtgtg ttctttagtt     1532

ttattttatt ttattttatt tttttaccct tcctcaaaca ccagtaacta ttattaactc     1592

gttttgctga atgttgttgg gtggtagaaa atgatagaac aagggaataa ccgcgaatgc     1652

tctgtgcagc tggactctgt ttccggaaag taaatgattt gctttttatg cctgttctga     1712

atggcagcac gaagcaggcc tgttacttgt atgtcgcttt ggacagagga aagtggggta     1772

aaatgctacc tgtacgtctg acatgaaaac ttctcaccgc ctcagcagct gaactaaaaa     1832

cctgaatagc catgacaaga gtttgcattt tcttgatgat tcatctccat gagtgcacaa     1892

tccctgaact cactgtcttt tctccacact tgtcctaagc caaggtagat ttgtacgtag     1952

acagactggt gagcaagcat tatattttat ttttaccctt gcatgacatt ttcattttaa     2012

tcaataacat tatttggcct gagcttgtgg gtctgttcag actgtctcct ctcatggttt     2072

gaaactgcat ctgaatgcct gccttcaatc ctggccaagt tggagtagac tggtatgaga     2132

aaactatgat tagttcacat ttactggtgc atccttgatc ctctcacaga tagaggtctt     2192

aaaggttgga tcatgtaaca ttgcttagta gaagaatctt cttctaagga tgatgggctt     2252

tctacagcct gcttaccact aacagtaagg aatctttcat aaacacacct cagtttgttc     2312

ccagtgggct tagagggagg acctgatgac tgattccagg atacttgtac ttctaataac     2372

atttttcatg aatcatgaga aaatttccac agatacttcc cttagaaaat ttgctataaa     2432

ctctgtatca ttggtagcac aaatttgagc gaggccttgt caattttaag gtggaaatag     2492

gaaggaccac aacatgaccc gtaagtcaag aaggtagaca tttcatatcc agcttccttg     2552

cttagtctcc tttcagtatt tggcaataaa agaaagaaga aatagaacag ctgaagtctc     2612

aaatcattgt ctggaatttt cctcaccttg gctagctcca cctgctcttt gtctaaggcc     2672

cttgcctcat cagggattag aactggccca tatgccagaa cctgtactaa atgcctaatt     2732

tgtatggaag agtgcatatt taatctcttt tctatactgc tcctttctga tgcttatcct     2792

ttcatctgtg tgattgtttt ttcccctcta ctaacaagat cctcccagct ttctctctac     2852

atgtagaaag gataacattt ctcatgaacc cactgcccct ctgcattttc ctcactggtt     2912

agagattaag taaataggat agaatatgct gcgtctcccc tgacacacac tttctttttt     2972

gaatgagcaa gtctccattt tgatttcagc aaagattttt tctccttttc tttgtcctca     3032

accatactta gaggaaagaa ggaatggtct tccatgaact gattatgctt aattaagcaa     3092

agtaaggaaa ttagtttcat ggaagcctaa acaaagctgg aatagaaact acacactaga     3152

cacagcagta gtcatagtct tcacaggttt aggagctact ggaccaacat tcttgttttt     3212

gcttttgttt ttttaaataa ttctagtctg gagctaactg tggagcagcc aaatagtagc     3272

tggcatgttg attcaaacca tgggctgaat ttgctcatag gctgtgcatc agacaaaagc     3332

ttgaatattt gtgttgtatg cttgttccaa ccaccgcttg tgtgagcatt tttgtggctt     3392

gtacagaaag tacactttta aattgtctct tgcatcacta aaattttttt aaaatgagca     3452

taacaacgaa aggcatccag ctgacttttt gattccaaga ttattgattg gattgacttt     3512

tttgcattaa atttttccca gcaaaataaa tcatatggcg agtcagggaa taaaaagtca     3572

aaagaaacaa atagaagctt ttttttttaa aaaatgtatt gcttctgaac ttttttctgc     3632

cactgctccc tagccctgtt tagtttgtta ttgctgcttt tcttttttct ttctgtatct     3692

atgccttttt ttcacagtag tccttggctc tgcacggaat aaatgatacc ctcaaatcta     3752

attggatgtg ctttcgcctt tgcatgtaag tacggtagta agaaaccttt gagatctttc     3812

tgacttttca aaattagaga aagcaaatgg gatggataga tttttttttt cttttcaagg     3872

ggggcaggaa ggtaatggtt tgagtagcct ttgtttaaaa aaaagactaa atatatttaa     3932

aaggccacat ttatattttt ttcacaagaa ccacataata aattccactt cttgacctga     3992

atttggaaat ccgaaattac taatccaggc caggtgtggt ggctcatgcc tgtaatccca     4052

gcactttgag aggccgaggt gggcagatca cttgaggcct ggagttcaag accaccttgg     4112

cgaacacggt gaaaccccgt ctctacaaaa aatacaaaaa ttagccaggc gtggtggcac     4172

gtgcctgtag tcccagctac ttgggaggct aagtcaggag aattgcttga acttgggaga     4232

tggaggttgc agtgagccaa gattgcacca ctgcattcca acctgggtga tgaagtgaga     4292

ctctccaaaa aaaaaaaaga aattattaat ccctgcctgt gctctacata gcctcatggg     4352

catcattgga tagctcagag ggcccttgat tctggcaagg caaataaagc cagaatgaga     4412

aattaccatc ttctactaga gaaaaccaag agaaaaattt ttatgctagg atgcctttat     4472

gaccacttaa ttttttaatc ttagtttaat ggtctctccc tggtgctaac tgctgacagt     4532

ggccacctct tttttgggga ttgaggggcc tacataacta gctggcctta ccccatatct     4592

tttgttcaaa cataatacca tctttttgct tcttctgaac tttagatctc cataacacat     4652

gtactgtaga atgtgatgga aaagcattga tgagaattta ttggcagttc agattgtgtt     4712

ttcccaactt aggctcttta ttaattggtt aaggttttct ccaaaaaggg catttcaaca     4772

atgggaatta tttaatgtaa cagtgggcac agattactta tcttccttct ctgctttgtg     4832

actcaccagc agtaacacac acaatccaca tcttgtgcac ctcaaatgaa cagacttggt     4892

ttccttgctt tcttgacatt tccatgactg tttcacatac aaactattgg gtgaggtttt     4952

tcagctgtta ccgacccacg tcctgctgtc tctgtgtggt cctacaaaaa ctgtccattc     5012

ccaccccttt gctttgccat ttgcaagagt ctggaattgt caggtctcag cttcgaaaag     5072

tcctggttcc actgacagga cacattcttt agtgggaatt aagacctaca aagtctagtt     5132

tgtatgtagg tatgaaggga attttttaaa taaattgaaa agctgtgaac agcattagaa     5192

ctttgtctat ttcttaattt taaaatatgc tgatatgcct taaactgtag ttgtagatcc     5252

ttgtcatttt gctgtttgaa aataaccaat gtgttttcta aaactgtcgt gtaatctact     5312

ttcattgtta atgcagaatt gtcatatatg taagctgcat gttagacatt tgtctttttt     5372

aaactaaagt aattgtattg atgtgaagca tatcattttt tcaaatatga aagtgatcac     5432

ttagcaacat gcttggtaat ttggcatctg ttaaggtagg agagtggtga acagataatc     5492

tatgcatata tcactagtgc caagacataa agcgggggaa aatatatttt tacccaaaca     5552

ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      5582


<210>  820
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  820

Met Ala Val Ala Val Gly Arg Pro Ser Asn Glu Glu Leu Arg Asn Leu 
1               5                   10                  15      


Ser Leu Ser Gly His Val Gly Phe Asp Ser Leu Pro Asp Gln Leu Val 
            20                  25                  30          


Asn Lys Ser Thr Ser Gln Gly Phe Cys Phe Asn Ile Leu Cys Val Gly 
        35                  40                  45              


Glu Thr Gly Ile Gly Lys Ser Thr Leu Met Asp Thr Leu Phe Asn Thr 
    50                  55                  60                  


Lys Phe Glu Ser Asp Pro Ala Thr His Asn Glu Pro Gly Val Arg Leu 
65                  70                  75                  80  


Lys Ala Arg Ser Tyr Glu Leu Gln Glu Ser Asn Val Arg Leu Lys Leu 
                85                  90                  95      


Thr Ile Val Asp Thr Val Gly Phe Gly Asp Gln Ile Asn Lys Asp Asp 
            100                 105                 110         


Ser Tyr Lys Pro Ile Val Glu Tyr Ile Asp Ala Gln Phe Glu Ala Tyr 
        115                 120                 125             


Leu Gln Glu Glu Leu Lys Ile Lys Arg Ser Leu Phe Asn Tyr His Asp 
    130                 135                 140                 


Thr Arg Ile His Ala Cys Leu Tyr Phe Ile Ala Pro Thr Gly His Ser 
145                 150                 155                 160 


Leu Lys Ser Leu Asp Leu Val Thr Met Lys Lys Leu Asp Ser Lys Val 
                165                 170                 175     


Asn Ile Ile Pro Ile Ile Ala Lys Ala Asp Thr Ile Ala Lys Asn Glu 
            180                 185                 190         


Leu His Lys Phe Lys Ser Lys Ile Met Ser Glu Leu Val Ser Asn Gly 
        195                 200                 205             


Val Gln Ile Tyr Gln Phe Pro Thr Asp Glu Glu Thr Val Ala Glu Ile 
    210                 215                 220                 


Asn Ala Thr Met Ser Val His Leu Pro Phe Ala Val Val Gly Ser Thr 
225                 230                 235                 240 


Glu Glu Val Lys Ile Gly Asn Lys Met Ala Lys Ala Arg Gln Tyr Pro 
                245                 250                 255     


Trp Gly Val Val Gln Val Glu Asn Glu Asn His Cys Asp Phe Val Lys 
            260                 265                 270         


Leu Arg Glu Met Leu Ile Arg Val Asn Met Glu Asp Leu Arg Glu Gln 
        275                 280                 285             


Thr His Thr Arg His Tyr Glu Leu Tyr Arg Arg Cys Lys Leu Glu Glu 
    290                 295                 300                 


Met Gly Phe Lys Asp Thr Asp Pro Asp Ser Lys Pro Phe Ser Leu Gln 
305                 310                 315                 320 


Glu Thr Tyr Glu Ala Lys Arg Asn Glu Phe Leu Gly Glu Leu Gln Lys 
                325                 330                 335     


Lys Glu Glu Glu Met Arg Gln Met Phe Val Met Arg Val Lys Glu Lys 
            340                 345                 350         


Glu Ala Glu Leu Lys Glu Ala Glu Lys Glu Leu His Glu Lys Phe Asp 
        355                 360                 365             


Leu Leu Lys Arg Thr His Gln Glu Glu Lys Lys Lys Val Glu Asp Lys 
    370                 375                 380                 


Lys Lys Glu Leu Glu Glu Glu Val Asn Asn Phe Gln Lys Lys Lys Ala 
385                 390                 395                 400 


Ala Ala Gln Leu Leu Gln Ser Gln Ala Gln Gln Ser Gly Ala Gln Gln 
                405                 410                 415     


Thr Lys Lys Asp Lys Asp Lys Lys Asn Ala Ser Phe Thr 
            420                 425                 


<210>  821
<211>  5927
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (127)..(4521)

<400>  821
tcgtcggagc agacgggagt ttctcctcgg ggtcggagca ggaggcacgc ggagtgtgag       60

gccacgcatg agcggacgct aaccccctcc ccagccacaa agagtctaca tgtctagggt      120

ctagac atg ttc agc ttt gtg gac ctc cgg ctc ctg ctc ctc tta gcg         168
       Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala            
       1               5                   10                             

gcc acc gcc ctc ctg acg cac ggc caa gag gaa ggc caa gtc gag ggc        216
Ala Thr Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly           
15                  20                  25                  30            

caa gac gaa gac atc cca cca atc acc tgc gta cag aac ggc ctc agg        264
Gln Asp Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg           
                35                  40                  45                

tac cat gac cga gac gtg tgg aaa ccc gag ccc tgc cgg atc tgc gtc        312
Tyr His Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val           
            50                  55                  60                    

tgc gac aac ggc aag gtg ttg tgc gat gac gtg atc tgt gac gag acc        360
Cys Asp Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr           
        65                  70                  75                        

aag aac tgc ccc ggc gcc gaa gtc ccc gag ggc gag tgc tgt ccc gtc        408
Lys Asn Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val           
    80                  85                  90                            

tgc ccc gac ggc tca gag tca ccc acc gac caa gaa acc acc ggc gtc        456
Cys Pro Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val           
95                  100                 105                 110           

gag gga ccc aag gga gac act ggc ccc cga ggc cca agg gga ccc gca        504
Glu Gly Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala           
                115                 120                 125               

ggc ccc cct ggc cga gat ggc atc cct gga cag cct gga ctt ccc gga        552
Gly Pro Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly           
            130                 135                 140                   

ccc ccc gga ccc ccc gga cct ccc gga ccc cct ggc ctc gga gga aac        600
Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn           
        145                 150                 155                       

ttt gct ccc cag ctg tct tat ggc tat gat gag aaa tca acc gga gga        648
Phe Ala Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly           
    160                 165                 170                           

att tcc gtg cct ggc ccc atg ggt ccc tct ggt cct cgt ggt ctc cct        696
Ile Ser Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro           
175                 180                 185                 190           

ggc ccc cct ggt gca cct ggt ccc caa ggc ttc caa ggt ccc cct ggt        744
Gly Pro Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly           
                195                 200                 205               

gag cct ggc gag cct gga gct tca ggt ccc atg ggt ccc cga ggt ccc        792
Glu Pro Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro           
            210                 215                 220                   

cca ggt ccc cct gga aag aat gga gat gat ggg gaa gct gga aaa cct        840
Pro Gly Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro           
        225                 230                 235                       

ggt cgt cct ggt gag cgt ggg cct cct ggg cct cag ggt gct cga gga        888
Gly Arg Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly           
    240                 245                 250                           

ttg ccc gga aca gct ggc ctc cct gga atg aag gga cac aga ggt ttc        936
Leu Pro Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe           
255                 260                 265                 270           

agt ggt ttg gat ggt gcc aag gga gat gct ggt cct gct ggt cct aag        984
Ser Gly Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys           
                275                 280                 285               

ggt gag cct ggc agc cct ggt gaa aat gga gct cct ggt cag atg ggc       1032
Gly Glu Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly           
            290                 295                 300                   

ccc cgt ggc ctg cct ggt gag aga ggt cgc cct gga gcc cct ggc cct       1080
Pro Arg Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro           
        305                 310                 315                       

gct ggt gct cgt gga aat gat ggt gct act ggt gct gcc ggg ccc cct       1128
Ala Gly Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro           
    320                 325                 330                           

ggt ccc acc ggc ccc gct ggt cct cct ggc ttc cct ggt gct gtt ggt       1176
Gly Pro Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly           
335                 340                 345                 350           

gct aag ggt gaa gct ggt ccc caa ggg ccc cga ggc tct gaa ggt ccc       1224
Ala Lys Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro           
                355                 360                 365               

cag ggt gtg cgt ggt gag cct ggc ccc cct ggc cct gct ggt gct gct       1272
Gln Gly Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala           
            370                 375                 380                   

ggc cct gct gga aac cct ggt gct gat gga cag cct ggt gct aaa ggt       1320
Gly Pro Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly           
        385                 390                 395                       

gcc aat ggt gct cct ggt att gct ggt gct cct ggc ttc cct ggt gcc       1368
Ala Asn Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala           
    400                 405                 410                           

cga ggc ccc tct gga ccc cag ggc ccc ggc ggc cct cct ggt ccc aag       1416
Arg Gly Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys           
415                 420                 425                 430           

ggt aac agc ggt gaa cct ggt gct cct ggc agc aaa gga gac act ggt       1464
Gly Asn Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly           
                435                 440                 445               

gct aag gga gag cct ggc cct gtt ggt gtt caa gga ccc cct ggc cct       1512
Ala Lys Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro           
            450                 455                 460                   

gct gga gag gaa gga aag cga gga gct cga ggt gaa ccc gga ccc act       1560
Ala Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr           
        465                 470                 475                       

ggc ctg ccc gga ccc cct ggc gag cgt ggt gga cct ggt agc cgt ggt       1608
Gly Leu Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly           
    480                 485                 490                           

ttc cct ggc gca gat ggt gtt gct ggt ccc aag ggt ccc gct ggt gaa       1656
Phe Pro Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu           
495                 500                 505                 510           

cgt ggt tct cct ggc cct gct ggc ccc aaa gga tct cct ggt gaa gct       1704
Arg Gly Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala           
                515                 520                 525               

ggt cgt ccc ggt gaa gct ggt ctg cct ggt gcc aag ggt ctg act gga       1752
Gly Arg Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly           
            530                 535                 540                   

agc cct ggc agc cct ggt cct gat ggc aaa act ggc ccc cct ggt ccc       1800
Ser Pro Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro           
        545                 550                 555                       

gcc ggt caa gat ggt cgc ccc gga ccc cca ggc cca cct ggt gcc cgt       1848
Ala Gly Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg           
    560                 565                 570                           

ggt cag gct ggt gtg atg gga ttc cct gga cct aaa ggt gct gct gga       1896
Gly Gln Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly           
575                 580                 585                 590           

gag ccc ggc aag gct gga gag cga ggt gtt ccc gga ccc cct ggc gct       1944
Glu Pro Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala           
                595                 600                 605               

gtc ggt cct gct ggc aaa gat gga gag gct gga gct cag gga ccc cct       1992
Val Gly Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro           
            610                 615                 620                   

ggc cct gct ggt ccc gct ggc gag aga ggt gaa caa ggc cct gct ggc       2040
Gly Pro Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly           
        625                 630                 635                       

tcc ccc gga ttc cag ggt ctc cct ggt cct gct ggt cct cca ggt gaa       2088
Ser Pro Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu           
    640                 645                 650                           

gca ggc aaa cct ggt gaa cag ggt gtt cct gga gac ctt ggc gcc cct       2136
Ala Gly Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro           
655                 660                 665                 670           

ggc ccc tct gga gca aga ggc gag aga ggt ttc cct ggc gag cgt ggt       2184
Gly Pro Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly           
                675                 680                 685               

gtg caa ggt ccc cct ggt cct gct ggt ccc cga ggg gcc aac ggt gct       2232
Val Gln Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala           
            690                 695                 700                   

ccc ggc aac gat ggt gct aag ggt gat gct ggt gcc cct gga gct ccc       2280
Pro Gly Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro           
        705                 710                 715                       

ggt agc cag ggc gcc cct ggc ctt cag gga atg cct ggt gaa cgt ggt       2328
Gly Ser Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly           
    720                 725                 730                           

gca gct ggt ctt cca ggg cct aag ggt gac aga ggt gat gct ggt ccc       2376
Ala Ala Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro           
735                 740                 745                 750           

aaa ggt gct gat ggc tct cct ggc aaa gat ggc gtc cgt ggt ctg act       2424
Lys Gly Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr           
                755                 760                 765               

ggc ccc att ggt cct cct ggc cct gct ggt gcc cct ggt gac aag ggt       2472
Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly           
            770                 775                 780                   

gaa agt ggt ccc agc ggc cct gct ggt ccc act gga gct cgt ggt gcc       2520
Glu Ser Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala           
        785                 790                 795                       

ccc gga gac cgt ggt gag cct ggt ccc ccc ggc cct gct ggc ttt gct       2568
Pro Gly Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala           
    800                 805                 810                           

ggc ccc cct ggt gct gac ggc caa cct ggt gct aaa ggc gaa cct ggt       2616
Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly           
815                 820                 825                 830           

gat gct ggt gct aaa ggc gat gct ggt ccc cct ggc cct gcc gga ccc       2664
Asp Ala Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro           
                835                 840                 845               

gct gga ccc cct ggc ccc att ggt aat gtt ggt gct cct gga gcc aaa       2712
Ala Gly Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys           
            850                 855                 860                   

ggt gct cgc ggc agc gct ggt ccc cct ggt gct act ggt ttc cct ggt       2760
Gly Ala Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly           
        865                 870                 875                       

gct gct ggc cga gtc ggt cct cct ggc ccc tct gga aat gct gga ccc       2808
Ala Ala Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro           
    880                 885                 890                           

cct ggc cct cct ggt cct gct ggc aaa gaa ggc ggc aaa ggt ccc cgt       2856
Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg           
895                 900                 905                 910           

ggt gag act ggc cct gct gga cgt cct ggt gaa gtt ggt ccc cct ggt       2904
Gly Glu Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly           
                915                 920                 925               

ccc cct ggc cct gct ggc gag aaa gga tcc cct ggt gct gat ggt cct       2952
Pro Pro Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro           
            930                 935                 940                   

gct ggt gct cct ggt act ccc ggg cct caa ggt att gct gga cag cgt       3000
Ala Gly Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg           
        945                 950                 955                       

ggt gtg gtc ggc ctg cct ggt cag aga gga gag aga ggc ttc cct ggt       3048
Gly Val Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly           
    960                 965                 970                           

ctt cct ggc ccc tct ggt gaa cct ggc aaa caa ggt ccc tct gga gca       3096
Leu Pro Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala           
975                 980                 985                 990           

agt ggt gaa cgt ggt ccc cct ggt ccc atg  ggc ccc cct gga ttg  gct     3144
Ser Gly Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala         
                995                 1000                 1005             

gga ccc cct ggt  gaa tct gga cgt gag  ggg gct cct ggt gcc  gaa        3189
Gly Pro Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu            
            1010                 1015                 1020                

ggt tcc cct gga  cga gac ggt tct cct  ggc gcc aag ggt gac  cgt        3234
Gly Ser Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg            
            1025                 1030                 1035                

ggt gag acc ggc  ccc gct gga ccc cct  ggt gct cct ggt gct  cct        3279
Gly Glu Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro            
            1040                 1045                 1050                

ggt gcc cct ggc  ccc gtt ggc cct gct  ggc aag agt ggt gat  cgt        3324
Gly Ala Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg            
            1055                 1060                 1065                

ggt gag act ggt  cct gct ggt ccc gcc  ggt cct gtc ggc cct  gtt        3369
Gly Glu Thr Gly  Pro Ala Gly Pro Ala  Gly Pro Val Gly Pro  Val            
            1070                 1075                 1080                

ggc gcc cgt ggc  ccc gcc gga ccc caa  ggc ccc cgt ggt gac  aag        3414
Gly Ala Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys            
            1085                 1090                 1095                

ggt gag aca ggc  gaa cag ggc gac aga  ggc ata aag ggt cac  cgt        3459
Gly Glu Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg            
            1100                 1105                 1110                

ggc ttc tct ggc  ctc cag ggt ccc cct  ggc cct cct ggc tct  cct        3504
Gly Phe Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro            
            1115                 1120                 1125                

ggt gaa caa ggt  ccc tct gga gcc tct  ggt cct gct ggt ccc  cga        3549
Gly Glu Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg            
            1130                 1135                 1140                

ggt ccc cct ggc  tct gct ggt gct cct  ggc aaa gat gga ctc  aac        3594
Gly Pro Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn            
            1145                 1150                 1155                

ggt ctc cct ggc  ccc att ggg ccc cct  ggt cct cgc ggt cgc  act        3639
Gly Leu Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr            
            1160                 1165                 1170                

ggt gat gct ggt  cct gtt ggt ccc ccc  ggc cct cct gga cct  cct        3684
Gly Asp Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro            
            1175                 1180                 1185                

ggt ccc cct ggt  cct ccc agc gct ggt  ttc gac ttc agc ttc  ctg        3729
Gly Pro Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu            
            1190                 1195                 1200                

ccc cag cca cct  caa gag aag gct cac  gat ggt ggc cgc tac  tac        3774
Pro Gln Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr            
            1205                 1210                 1215                

cgg gct gat gat  gcc aat gtg gtt cgt  gac cgt gac ctc gag  gtg        3819
Arg Ala Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val            
            1220                 1225                 1230                

gac acc acc ctc  aag agc ctg agc cag  cag atc gag aac atc  cgg        3864
Asp Thr Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg            
            1235                 1240                 1245                

agc cca gag ggc  agc cgc aag aac ccc  gcc cgc acc tgc cgt  gac        3909
Ser Pro Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp            
            1250                 1255                 1260                

ctc aag atg tgc  cac tct gac tgg aag  agt gga gag tac tgg  att        3954
Leu Lys Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile            
            1265                 1270                 1275                

gac ccc aac caa  ggc tgc aac ctg gat  gcc atc aaa gtc ttc  tgc        3999
Asp Pro Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys            
            1280                 1285                 1290                

aac atg gag act  ggt gag acc tgc gtg  tac ccc act cag ccc  agt        4044
Asn Met Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser            
            1295                 1300                 1305                

gtg gcc cag aag  aac tgg tac atc agc  aag aac ccc aag gac  aag        4089
Val Ala Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys            
            1310                 1315                 1320                

agg cat gtc tgg  ttc ggc gag agc atg  acc gat gga ttc cag  ttc        4134
Arg His Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe            
            1325                 1330                 1335                

gag tat ggc ggc  cag ggc tcc gac cct  gcc gat gtg gcc atc  cag        4179
Glu Tyr Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln            
            1340                 1345                 1350                

ctg acc ttc ctg  cgc ctg atg tcc acc  gag gcc tcc cag aac  atc        4224
Leu Thr Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile            
            1355                 1360                 1365                

acc tac cac tgc  aag aac agc gtg gcc  tac atg gac cag cag  act        4269
Thr Tyr His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr            
            1370                 1375                 1380                

ggc aac ctc aag  aag gcc ctg ctc ctc  cag ggc tcc aac gag  atc        4314
Gly Asn Leu Lys  Lys Ala Leu Leu Leu  Gln Gly Ser Asn Glu  Ile            
            1385                 1390                 1395                

gag atc cgc gcc  gag ggc aac agc cgc  ttc acc tac agc gtc  act        4359
Glu Ile Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr            
            1400                 1405                 1410                

gtc gat ggc tgc  acg agt cac acc gga  gcc tgg ggc aag aca  gtg        4404
Val Asp Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val            
            1415                 1420                 1425                

att gaa tac aaa  acc acc aag acc tcc  cgc ctg ccc atc atc  gat        4449
Ile Glu Tyr Lys  Thr Thr Lys Thr Ser  Arg Leu Pro Ile Ile  Asp            
            1430                 1435                 1440                

gtg gcc ccc ttg  gac gtt ggt gcc cca  gac cag gaa ttc ggc  ttc        4494
Val Ala Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe            
            1445                 1450                 1455                

gac gtt ggc cct  gtc tgc ttc ctg taa actccctcca tcccaacctg            4541
Asp Val Gly Pro  Val Cys Phe Leu                                          
            1460                                                          

gctccctccc acccaaccaa ctttcccccc aacccggaaa cagacaagca acccaaactg     4601

aaccccctca aaagccaaaa aatgggagac aatttcacat ggactttgga aaatattttt     4661

ttcctttgca ttcatctctc aaacttagtt tttatctttg accaaccgaa catgaccaaa     4721

aaccaaaagt gcattcaacc ttaccaaaaa aaaaaaaaaa aaaagaataa ataaataact     4781

ttttaaaaaa ggaagcttgg tccacttgct tgaagaccca tgcgggggta agtccctttc     4841

tgcccgttgg gcttatgaaa ccccaatgct gccctttctg ctcctttctc cacacccccc     4901

ttggggcctc ccctccactc cttcccaaat ctgtctcccc agaagacaca ggaaacaatg     4961

tattgtctgc ccagcaatca aaggcaatgc tcaaacaccc aagtggcccc caccctcagc     5021

ccgctcctgc ccgcccagca cccccaggcc ctgggggacc tggggttctc agactgccaa     5081

agaagccttg ccatctggcg ctcccatggc tcttgcaaca tctccccttc gtttttgagg     5141

gggtcatgcc gggggagcca ccagcccctc actgggttcg gaggagagtc aggaagggcc     5201

acgacaaagc agaaacatcg gatttgggga acgcgtgtca atcccttgtg ccgcagggct     5261

gggcgggaga gactgttctg ttccttgtgt aactgtgttg ctgaaagact acctcgttct     5321

tgtcttgatg tgtcaccggg gcaactgcct gggggcgggg atgggggcag ggtggaagcg     5381

gctccccatt ttataccaaa ggtgctacat ctatgtgatg ggtggggtgg ggagggaatc     5441

actggtgcta tagaaattga gatgcccccc caggccagca aatgttcctt tttgttcaaa     5501

gtctattttt attccttgat atttttcttt tttttttttt ttttttgtgg atggggactt     5561

gtgaattttt ctaaaggtgc tatttaacat gggaggagag cgtgtgcggc tccagcccag     5621

cccgctgctc actttccacc ctctctccac ctgcctctgg cttctcaggc ctctgctctc     5681

cgacctctct cctctgaaac cctcctccac agctgcagcc catcctcccg gctccctcct     5741

agtctgtcct gcgtcctctg tccccgggtt tcagagacaa cttcccaaag cacaaagcag     5801

tttttccccc taggggtggg aggaagcaaa agactctgta cctattttgt atgtgtataa     5861

taatttgaga tgtttttaat tattttgatt gctggaataa agcatgtgga aatgacccaa     5921

acataa                                                                5927


<210>  822
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  822

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          


Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 
65                  70                  75                  80  


Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 
                165                 170                 175     


Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         


Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             


Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     


Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         


Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             


Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 


Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 


Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     


Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         


Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             


Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 


Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     


Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         


Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 
        435                 440                 445             


Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 


Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 
465                 470                 475                 480 


Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     


Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         


Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             


Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 
    530                 535                 540                 


Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     


Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         


Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             


Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 


Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 


Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     


Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         


Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             


Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 


Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 


Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     


Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         


Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 
        755                 760                 765             


Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 


Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     


Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         


Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             


Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 


Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 


Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         


Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             


Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 


Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 


Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     


Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         


Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser 
    1010                 1015                 1020             


Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1025                 1030                 1035             


Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 
    1040                 1045                 1050             


Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 
    1055                 1060                 1065             


Thr Gly  Pro Ala Gly Pro Ala  Gly Pro Val Gly Pro  Val Gly Ala 
    1070                 1075                 1080             


Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 
    1085                 1090                 1095             


Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 
    1100                 1105                 1110             


Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 
    1115                 1120                 1125             


Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 
    1145                 1150                 1155             


Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp 
    1160                 1165                 1170             


Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 
    1190                 1195                 1200             


Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 
    1205                 1210                 1215             


Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr 
    1220                 1225                 1230             


Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 
    1235                 1240                 1245             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 
    1250                 1255                 1260             


Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 
    1265                 1270                 1275             


Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 
    1280                 1285                 1290             


Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala 
    1295                 1300                 1305             


Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 
    1310                 1315                 1320             


Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr 
    1325                 1330                 1335             


Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr 
    1340                 1345                 1350             


Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr 
    1355                 1360                 1365             


His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn 
    1370                 1375                 1380             


Leu Lys  Lys Ala Leu Leu Leu  Gln Gly Ser Asn Glu  Ile Glu Ile 
    1385                 1390                 1395             


Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp 
    1400                 1405                 1410             


Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu 
    1415                 1420                 1425             


Tyr Lys  Thr Thr Lys Thr Ser  Arg Leu Pro Ile Ile  Asp Val Ala 
    1430                 1435                 1440             


Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 
    1445                 1450                 1455             


Gly Pro  Val Cys Phe Leu 
    1460                 


<210>  823
<211>  4077
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (359)..(1906)

<400>  823
gtaagtgtga ggggcatgag tatacacgag tgtgcgtgtc tttccctctc ccttatttgt       60

ctccgtatga gtctctcctt gtaccctccc cctgcctcga tgatattact cccccagact      120

tggaagccgc tgccagagtg acgctttgat ggtatctgca agcgtttttg ctgatcttat      180

ctctgccccc tgaatattaa ttccctaatc tggtagcaat ccatctcccc agtgaaggac      240

ctactagagg caggtggggg gagccaccat cagatcataa gcataagaat aatacaaagg      300

ggagggattc ttctgcaacc aagaggcaag aggcgagaga aggaaaaaaa aaaaagcg        358

atg agt tcg cca aat ata tgg agc aca gga agc tca gtc tac tcg act        406
Met Ser Ser Pro Asn Ile Trp Ser Thr Gly Ser Ser Val Tyr Ser Thr           
1               5                   10                  15                

cct gta ttt tca cag aaa atg acg gtg tgg att ctg ctc ctg ctg tcg        454
Pro Val Phe Ser Gln Lys Met Thr Val Trp Ile Leu Leu Leu Leu Ser           
            20                  25                  30                    

ctc tac cct ggc ttc act agc cag aaa tct gat gat gac tat gaa gat        502
Leu Tyr Pro Gly Phe Thr Ser Gln Lys Ser Asp Asp Asp Tyr Glu Asp           
        35                  40                  45                        

tat gct tct aac aaa aca tgg gtc ttg act cca aaa gtt cct gag ggt        550
Tyr Ala Ser Asn Lys Thr Trp Val Leu Thr Pro Lys Val Pro Glu Gly           
    50                  55                  60                            

gat gtc act gtc atc tta aac aac ctg ctg gaa gga tat gac aat aaa        598
Asp Val Thr Val Ile Leu Asn Asn Leu Leu Glu Gly Tyr Asp Asn Lys           
65                  70                  75                  80            

ctt cgg cct gat ata gga gtg aag cca acg tta att cac aca gac atg        646
Leu Arg Pro Asp Ile Gly Val Lys Pro Thr Leu Ile His Thr Asp Met           
                85                  90                  95                

tat gtg aat agc att ggt cca gtg aac gct atc aat atg gaa tac act        694
Tyr Val Asn Ser Ile Gly Pro Val Asn Ala Ile Asn Met Glu Tyr Thr           
            100                 105                 110                   

att gat ata ttt ttt gcg caa acg tgg tat gac aga cgt ttg aaa ttt        742
Ile Asp Ile Phe Phe Ala Gln Thr Trp Tyr Asp Arg Arg Leu Lys Phe           
        115                 120                 125                       

aac agc acc att aaa gtc ctc cga ttg aac agc aac atg gtg ggg aaa        790
Asn Ser Thr Ile Lys Val Leu Arg Leu Asn Ser Asn Met Val Gly Lys           
    130                 135                 140                           

atc tgg att cca gac act ttc ttc aga aat tcc aaa aaa gct gat gca        838
Ile Trp Ile Pro Asp Thr Phe Phe Arg Asn Ser Lys Lys Ala Asp Ala           
145                 150                 155                 160           

cac tgg atc acc acc ccc aac agg atg ctg aga att tgg aat gat ggt        886
His Trp Ile Thr Thr Pro Asn Arg Met Leu Arg Ile Trp Asn Asp Gly           
                165                 170                 175               

cga gtg ctc tac acc cta agg ttg aca att gat gct gag tgc caa tta        934
Arg Val Leu Tyr Thr Leu Arg Leu Thr Ile Asp Ala Glu Cys Gln Leu           
            180                 185                 190                   

caa ttg cac aac ttt cca atg gat gaa cac tcc tgc ccc ttg gag ttc        982
Gln Leu His Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Glu Phe           
        195                 200                 205                       

tcc agt tgg tct cgt tct att gcc cag gct gga atg tgc agt ggt gtg       1030
Ser Ser Trp Ser Arg Ser Ile Ala Gln Ala Gly Met Cys Ser Gly Val           
    210                 215                 220                           

atc tcg gct cac tac agc ctt cgc ttc tgg ggc tca act gat cct ccc       1078
Ile Ser Ala His Tyr Ser Leu Arg Phe Trp Gly Ser Thr Asp Pro Pro           
225                 230                 235                 240           

acc ttg gcc tcc aga gta gct ggg att tca gat ggc tat cca cgt gaa       1126
Thr Leu Ala Ser Arg Val Ala Gly Ile Ser Asp Gly Tyr Pro Arg Glu           
                245                 250                 255               

gaa att gtt tat caa tgg aag cga agt tct gtt gaa gtg ggc gac aca       1174
Glu Ile Val Tyr Gln Trp Lys Arg Ser Ser Val Glu Val Gly Asp Thr           
            260                 265                 270                   

aga tcc tgg agg ctt tat caa ttc tca ttt gtt ggt cta aga aat acc       1222
Arg Ser Trp Arg Leu Tyr Gln Phe Ser Phe Val Gly Leu Arg Asn Thr           
        275                 280                 285                       

acc gaa gta gtg aag aca act tcc gga gat tat gtg gtc atg tct gtc       1270
Thr Glu Val Val Lys Thr Thr Ser Gly Asp Tyr Val Val Met Ser Val           
    290                 295                 300                           

tac ttt gat ctg agc aga aga atg gga tac ttt acc atc cag acc tat       1318
Tyr Phe Asp Leu Ser Arg Arg Met Gly Tyr Phe Thr Ile Gln Thr Tyr           
305                 310                 315                 320           

atc ccc tgc aca ctc att gtc gtc cta tcc tgg gtg tct ttc tgg atc       1366
Ile Pro Cys Thr Leu Ile Val Val Leu Ser Trp Val Ser Phe Trp Ile           
                325                 330                 335               

aat aag gat gct gtt cca gcc aga aca tct tta ggt atc acc act gtc       1414
Asn Lys Asp Ala Val Pro Ala Arg Thr Ser Leu Gly Ile Thr Thr Val           
            340                 345                 350                   

ctg aca atg acc acc ctc agc acc att gcc cgg aaa tcg ctc ccc aag       1462
Leu Thr Met Thr Thr Leu Ser Thr Ile Ala Arg Lys Ser Leu Pro Lys           
        355                 360                 365                       

gtc tcc tat gtc aca gcg atg gat ctc ttt gta tct gtt tgt ttc atc       1510
Val Ser Tyr Val Thr Ala Met Asp Leu Phe Val Ser Val Cys Phe Ile           
    370                 375                 380                           

ttt gtc ttc tct gct ctg gtg gag tat ggc acc ttg cat tat ttt gtc       1558
Phe Val Phe Ser Ala Leu Val Glu Tyr Gly Thr Leu His Tyr Phe Val           
385                 390                 395                 400           

agc aac cgg aaa cca agc aag gac aaa gat aaa aag aag aaa aac cct       1606
Ser Asn Arg Lys Pro Ser Lys Asp Lys Asp Lys Lys Lys Lys Asn Pro           
                405                 410                 415               

ctt ctt cgg atg ttt tcc ttc aag gcc cct acc att gat atc cgc cca       1654
Leu Leu Arg Met Phe Ser Phe Lys Ala Pro Thr Ile Asp Ile Arg Pro           
            420                 425                 430                   

aga tca gca acc att caa atg aat aat gct aca cac ctt caa gag aga       1702
Arg Ser Ala Thr Ile Gln Met Asn Asn Ala Thr His Leu Gln Glu Arg           
        435                 440                 445                       

gat gaa gag tac ggc tat gag tgt ctg gac ggc aag gac tgt gcc agt       1750
Asp Glu Glu Tyr Gly Tyr Glu Cys Leu Asp Gly Lys Asp Cys Ala Ser           
    450                 455                 460                           

ttt ttc tgc tgt ttt gaa gat tgt cga aca gga gct tgg aga cat ggg       1798
Phe Phe Cys Cys Phe Glu Asp Cys Arg Thr Gly Ala Trp Arg His Gly           
465                 470                 475                 480           

agg ata cat atc cgc att gcc aaa atg gac tcc tat gct cgg atc ttc       1846
Arg Ile His Ile Arg Ile Ala Lys Met Asp Ser Tyr Ala Arg Ile Phe           
                485                 490                 495               

ttc ccc act gcc ttc tgc ctg ttt aat ctg gtc tat tgg gtc tcc tac       1894
Phe Pro Thr Ala Phe Cys Leu Phe Asn Leu Val Tyr Trp Val Ser Tyr           
            500                 505                 510                   

ctc tac ctg tga ggaggtatgg gttttactga tatggttctt attcactgag           1946
Leu Tyr Leu                                                               
        515                                                               

tctcatggag agatgtctgt tctaagtcca cttaaataat cctctatgtg gttgataatg     2006

atctgaatct gtttctatgt ccaaacctgg taaattttat aatgtcatat tgtttgtgcc     2066

cagccctcct ttggttagtg tactttgaac ttcgatgttt gctgtgtttc aaacctgcaa     2126

ggcaaagtaa aattagagca agaacattca aaccaaataa gatatttttc agctacagca     2186

aataaaacag tgaaagccct gactatttac agtagtggta tccttactag attcataatg     2246

caattagata gaaaaggtcc aaaactgtac cctatgttca ctccgggtca agttgtgata     2306

aatttgatcc caatagaata cctccctcat ttaagaaaaa tcataactca ctttaaatat     2366

gaaagcctag tccagaaatc tattacacct ttatctcaag ataggaagaa aatttcctcc     2426

acattcatgt acaatgatgt aaatatttca ataacttaga atgcttcaag tttagtgcat     2486

gcatctcttt agatccaaaa taaatggact gaagttatca tcctattgtc ttttattttg     2546

tgtccttggg ctataaaaga ttcctgaatg taattataag gatttgggtt tggaaatgga     2606

gggaggaatt ttcattgcct tctccctcat gcatgaagat tcgaacagct tattttttcc     2666

ttgtatgaca tattacaaca ctttaagtaa aatatagact ggataatcaa catttgccac     2726

ctctaaatat gcccaatttc ataactagag tataaagtaa ttgtatgtgc ttgccgctat     2786

ttttttcttc cttttaggat gatagatcat aacagaactt attctccatc tcaagatctg     2846

cttctagtga ttgtgagtgc cttgtgggca gaatccttgt catttcctct ttgggtctgt     2906

agcaccttgc atagtgcctg gcatatagtt ggtgctcaat aaatatggtt tgaagtgaat     2966

tgccctcaca tgcttctggc aaatctctgt gctggcctga aaccagtgac tcatcttctc     3026

acataggtgt tgtcaagtga tatttgattt tgtaaaaata accagtagga tccaaagaac     3086

tttagctatt tatgttcatc ttcaaaaaat tattttaggc aaagtccata ctccttttaa     3146

aacaatattt atgtcctatg tttgtgtata gacatgactc tactagggca taattagagt     3206

ttgtgtatta tttttccagg tttggggatg agtcagtcct tgcccatcca caattttgtt     3266

tgtgaactta taacaggaat aagcaaaatt catacctgac tagtgttcag aatgtagcat     3326

tctgtgcgaa aaagtattga agattagctt ttaaaaactg aaaaaaaaaa atgaatgact     3386

cacatagagg ttgagccaat gactgtggcc tcattagatt acattgtagt taaacaaagc     3446

aatttctcca gacttaaaac atgatgagtt gagctctatc ttcatgtact catcctgaat     3506

ccttattttt ctaaaatagc accctttgtt aattattttt atggaaatta ttactctgtc     3566

ataattaaat catagctagt ataactttac agataaccta aaaagaatag aaaagaagag     3626

agagtggctt tgtcagtata aaaccatgta aagtcatcat caagtcatct ggatgaatct     3686

tgaaacacat ttagctgcca gttttacaaa cctttaatat atcagtgctc cagtatataa     3746

cctcaaacaa atgtaaatag aacgaattat tttcttgttt tgaattgtca atatattaaa     3806

tgttgactct ttgggagagt tgttggcaag tttcaatggt gagaaacatt attgtcaact     3866

tgaaatgtgt tctgtaatgg ggacactaca aaaagctagc tttccaatgt gtgcatagta     3926

ttggcaatat gaatatatat tatatataat ctaatactta ttataagctg ctccctgtct     3986

atgtatttgg aaaccttttc acaaagggaa ttgcctaaca tgtggacttt tacaataaaa     4046

atgctgcatt ctaatccatg gtggcatctc a                                    4077


<210>  824
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  824

Met Ser Ser Pro Asn Ile Trp Ser Thr Gly Ser Ser Val Tyr Ser Thr 
1               5                   10                  15      


Pro Val Phe Ser Gln Lys Met Thr Val Trp Ile Leu Leu Leu Leu Ser 
            20                  25                  30          


Leu Tyr Pro Gly Phe Thr Ser Gln Lys Ser Asp Asp Asp Tyr Glu Asp 
        35                  40                  45              


Tyr Ala Ser Asn Lys Thr Trp Val Leu Thr Pro Lys Val Pro Glu Gly 
    50                  55                  60                  


Asp Val Thr Val Ile Leu Asn Asn Leu Leu Glu Gly Tyr Asp Asn Lys 
65                  70                  75                  80  


Leu Arg Pro Asp Ile Gly Val Lys Pro Thr Leu Ile His Thr Asp Met 
                85                  90                  95      


Tyr Val Asn Ser Ile Gly Pro Val Asn Ala Ile Asn Met Glu Tyr Thr 
            100                 105                 110         


Ile Asp Ile Phe Phe Ala Gln Thr Trp Tyr Asp Arg Arg Leu Lys Phe 
        115                 120                 125             


Asn Ser Thr Ile Lys Val Leu Arg Leu Asn Ser Asn Met Val Gly Lys 
    130                 135                 140                 


Ile Trp Ile Pro Asp Thr Phe Phe Arg Asn Ser Lys Lys Ala Asp Ala 
145                 150                 155                 160 


His Trp Ile Thr Thr Pro Asn Arg Met Leu Arg Ile Trp Asn Asp Gly 
                165                 170                 175     


Arg Val Leu Tyr Thr Leu Arg Leu Thr Ile Asp Ala Glu Cys Gln Leu 
            180                 185                 190         


Gln Leu His Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Glu Phe 
        195                 200                 205             


Ser Ser Trp Ser Arg Ser Ile Ala Gln Ala Gly Met Cys Ser Gly Val 
    210                 215                 220                 


Ile Ser Ala His Tyr Ser Leu Arg Phe Trp Gly Ser Thr Asp Pro Pro 
225                 230                 235                 240 


Thr Leu Ala Ser Arg Val Ala Gly Ile Ser Asp Gly Tyr Pro Arg Glu 
                245                 250                 255     


Glu Ile Val Tyr Gln Trp Lys Arg Ser Ser Val Glu Val Gly Asp Thr 
            260                 265                 270         


Arg Ser Trp Arg Leu Tyr Gln Phe Ser Phe Val Gly Leu Arg Asn Thr 
        275                 280                 285             


Thr Glu Val Val Lys Thr Thr Ser Gly Asp Tyr Val Val Met Ser Val 
    290                 295                 300                 


Tyr Phe Asp Leu Ser Arg Arg Met Gly Tyr Phe Thr Ile Gln Thr Tyr 
305                 310                 315                 320 


Ile Pro Cys Thr Leu Ile Val Val Leu Ser Trp Val Ser Phe Trp Ile 
                325                 330                 335     


Asn Lys Asp Ala Val Pro Ala Arg Thr Ser Leu Gly Ile Thr Thr Val 
            340                 345                 350         


Leu Thr Met Thr Thr Leu Ser Thr Ile Ala Arg Lys Ser Leu Pro Lys 
        355                 360                 365             


Val Ser Tyr Val Thr Ala Met Asp Leu Phe Val Ser Val Cys Phe Ile 
    370                 375                 380                 


Phe Val Phe Ser Ala Leu Val Glu Tyr Gly Thr Leu His Tyr Phe Val 
385                 390                 395                 400 


Ser Asn Arg Lys Pro Ser Lys Asp Lys Asp Lys Lys Lys Lys Asn Pro 
                405                 410                 415     


Leu Leu Arg Met Phe Ser Phe Lys Ala Pro Thr Ile Asp Ile Arg Pro 
            420                 425                 430         


Arg Ser Ala Thr Ile Gln Met Asn Asn Ala Thr His Leu Gln Glu Arg 
        435                 440                 445             


Asp Glu Glu Tyr Gly Tyr Glu Cys Leu Asp Gly Lys Asp Cys Ala Ser 
    450                 455                 460                 


Phe Phe Cys Cys Phe Glu Asp Cys Arg Thr Gly Ala Trp Arg His Gly 
465                 470                 475                 480 


Arg Ile His Ile Arg Ile Ala Lys Met Asp Ser Tyr Ala Arg Ile Phe 
                485                 490                 495     


Phe Pro Thr Ala Phe Cys Leu Phe Asn Leu Val Tyr Trp Val Ser Tyr 
            500                 505                 510         


Leu Tyr Leu 
        515 


<210>  825
<211>  1970
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (194)..(841)

<400>  825
ctttgaaaaa gacttctttt gagctaactt tcttatactg gtacctttct aatctcacta       60

caatatgtaa cattggtgtt cgatctcaag tatttctgaa tatattcccc tatccacaga      120

aatatactct gggggaaaaa aaatagaaca aattcttgcc gtcctgacca ttgaacaaga      180

gactaattag aca atg ggg cta gaa aaa cct caa agt aaa ctg gaa gga         229
               Met Gly Leu Glu Lys Pro Gln Ser Lys Leu Glu Gly            
               1               5                   10                     

ggc atg cat ccc cag ctg ata cct tcg gtt att gct gta gtt ttc atc        277
Gly Met His Pro Gln Leu Ile Pro Ser Val Ile Ala Val Val Phe Ile           
        15                  20                  25                        

tta ctt ctc agt gtc tgt ttt att gca agt tgt ttg gtg act cat cac        325
Leu Leu Leu Ser Val Cys Phe Ile Ala Ser Cys Leu Val Thr His His           
    30                  35                  40                            

aac ttt tca cgc tgt aag aga ggc aca gga gtg cac aag tta gag cac        373
Asn Phe Ser Arg Cys Lys Arg Gly Thr Gly Val His Lys Leu Glu His           
45                  50                  55                  60            

cat gca aag ctc aaa tgc atc aaa gag aaa tca gaa ctg aaa agt gct        421
His Ala Lys Leu Lys Cys Ile Lys Glu Lys Ser Glu Leu Lys Ser Ala           
                65                  70                  75                

gaa ggg agc acc tgg aac tgt tgt cct att gac tgg aga gcc ttc cag        469
Glu Gly Ser Thr Trp Asn Cys Cys Pro Ile Asp Trp Arg Ala Phe Gln           
            80                  85                  90                    

tcc aac tgc tat ttt cct ctt act gac aac aag acg tgg gct gag agt        517
Ser Asn Cys Tyr Phe Pro Leu Thr Asp Asn Lys Thr Trp Ala Glu Ser           
        95                  100                 105                       

gaa agg aac tgt tca ggg atg ggg gcc cat ctg atg acc atc agc acg        565
Glu Arg Asn Cys Ser Gly Met Gly Ala His Leu Met Thr Ile Ser Thr           
    110                 115                 120                           

gaa gct gag cag aac ttt att att cag ttt ctg gat aga cgg ctt tcc        613
Glu Ala Glu Gln Asn Phe Ile Ile Gln Phe Leu Asp Arg Arg Leu Ser           
125                 130                 135                 140           

tat ttc ctt gga ctt aga gat gag aat gcc aaa ggt cag tgg cgt tgg        661
Tyr Phe Leu Gly Leu Arg Asp Glu Asn Ala Lys Gly Gln Trp Arg Trp           
                145                 150                 155               

gtg gac cag acg cca ttt aac cca cgc aga gta ttc tgg cat aag aat        709
Val Asp Gln Thr Pro Phe Asn Pro Arg Arg Val Phe Trp His Lys Asn           
            160                 165                 170                   

gaa ccc gac aac tct cag gga gaa aac tgt gtt gtt ctt gtt tat aac        757
Glu Pro Asp Asn Ser Gln Gly Glu Asn Cys Val Val Leu Val Tyr Asn           
        175                 180                 185                       

caa gat aaa tgg gcc tgg aat gat gtt cct tgt aac ttt gaa gca agt        805
Gln Asp Lys Trp Ala Trp Asn Asp Val Pro Cys Asn Phe Glu Ala Ser           
    190                 195                 200                           

agg att tgt aaa ata cct gga aca aca ttg aac tag aaactcagaa             851
Arg Ile Cys Lys Ile Pro Gly Thr Thr Leu Asn                               
205                 210                 215                               

agtggtcctt gtgatggaaa gagaaaagaa aaaccaatta gaataaggca gaatgtacgt      911

gcgtcattgg aacacagaaa acatgctggt tcatacagcg tttttagtca taatggtctt      971

ttttattttg tttgattcat tcgagacaac atgtgtgtat gtgtgtgtgt gtgtgtgtag     1031

ataatgtggt ttttgtatgg tgtttgatgg aaggaataat ctttctttgc tttcttagta     1091

gtatttcaag gtgtttactt ttcaattggt gtgcactgaa tgcatgtatg gaagaatagc     1151

gtgaataatg caatctcttt gtcatttttc cccttctcag actcttagct cttaaaattc     1211

aaagatggga tattctaact ggtagtggtg catcattttt aacccaaata ttgcaagcac     1271

tttaaagatt tgaaaccaca tttttattgt ttgatgtttc attttcagac tttttaatgt     1331

cagtcattac aattacattg catgaggaaa atttttccag aacaacagtg tggaatagtt     1391

ctgaattatg ctgttctaca gatagaaaaa aagtccaaat gcctttaaaa atttacttct     1451

tactccaccc aacacgtttt tgcaaagcaa gaagtctttg taagacacct taaacaaagt     1511

ccttcaattc tacagcagag gaaataaaat cccccagaag ccaaagggct caccttcaca     1571

ttgttagttc atgacagacc caggtgtgct tcattagaga taacatacat tccctttggt     1631

atcacaggaa gttactgggg attactcgac ctcattactt agctaacgac tggataaaat     1691

ttcttaattg tttgaagtaa cattgtattc gtgtttgcat tattaatttg aatagaaaat     1751

aatcacattt tcaacccatt tatacaaatt gttaatgttt ctttagagct gtataactat     1811

agtttgaact agcaaggaag ttattgtttt gacaaccaga aattatgctt ttctggtgca     1871

tgaaacatta attgcaaagg gcagtcacat ccaactttaa taaaatatgg tggtctttct     1931

taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                            1970


<210>  826
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  826

Met Gly Leu Glu Lys Pro Gln Ser Lys Leu Glu Gly Gly Met His Pro 
1               5                   10                  15      


Gln Leu Ile Pro Ser Val Ile Ala Val Val Phe Ile Leu Leu Leu Ser 
            20                  25                  30          


Val Cys Phe Ile Ala Ser Cys Leu Val Thr His His Asn Phe Ser Arg 
        35                  40                  45              


Cys Lys Arg Gly Thr Gly Val His Lys Leu Glu His His Ala Lys Leu 
    50                  55                  60                  


Lys Cys Ile Lys Glu Lys Ser Glu Leu Lys Ser Ala Glu Gly Ser Thr 
65                  70                  75                  80  


Trp Asn Cys Cys Pro Ile Asp Trp Arg Ala Phe Gln Ser Asn Cys Tyr 
                85                  90                  95      


Phe Pro Leu Thr Asp Asn Lys Thr Trp Ala Glu Ser Glu Arg Asn Cys 
            100                 105                 110         


Ser Gly Met Gly Ala His Leu Met Thr Ile Ser Thr Glu Ala Glu Gln 
        115                 120                 125             


Asn Phe Ile Ile Gln Phe Leu Asp Arg Arg Leu Ser Tyr Phe Leu Gly 
    130                 135                 140                 


Leu Arg Asp Glu Asn Ala Lys Gly Gln Trp Arg Trp Val Asp Gln Thr 
145                 150                 155                 160 


Pro Phe Asn Pro Arg Arg Val Phe Trp His Lys Asn Glu Pro Asp Asn 
                165                 170                 175     


Ser Gln Gly Glu Asn Cys Val Val Leu Val Tyr Asn Gln Asp Lys Trp 
            180                 185                 190         


Ala Trp Asn Asp Val Pro Cys Asn Phe Glu Ala Ser Arg Ile Cys Lys 
        195                 200                 205             


Ile Pro Gly Thr Thr Leu Asn 
    210                 215 


<210>  827
<211>  2480
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (245)..(1387)

<400>  827
agtactaaca tggactaatc tgtgggagca gtttattcca gtatcaccca gggtgcagcc       60

acaccaggac tgtgttgaag ggtgtttttt ttcttttaaa tgtaatacct cctcatcttt      120

tcttcttaca cagtgtctga gaacatttac attatagata agtagtacat ggtggataac      180

ttctactttt aggaggacta ctctcttctg acagtcctag actggtcttc tacactaaga      240

cacc atg aag gag tat gtg ctc cta tta ttc ctg gct ttg tgc tct gcc       289
     Met Lys Glu Tyr Val Leu Leu Leu Phe Leu Ala Leu Cys Ser Ala          
     1               5                   10                  15           

aaa ccc ttc ttt agc cct tca cac atc gca ctg aag aat atg atg ctg        337
Lys Pro Phe Phe Ser Pro Ser His Ile Ala Leu Lys Asn Met Met Leu           
                20                  25                  30                

aag gat atg gaa gac aca gat gat gat gat gat gat gat gat gat gat        385
Lys Asp Met Glu Asp Thr Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp           
            35                  40                  45                    

gat gat gat gat gag gac aac tct ctt ttt cca aca aga gag cca aga        433
Asp Asp Asp Asp Glu Asp Asn Ser Leu Phe Pro Thr Arg Glu Pro Arg           
        50                  55                  60                        

agc cat ttt ttt cca ttt gat ctg ttt cca atg tgt cca ttt gga tgt        481
Ser His Phe Phe Pro Phe Asp Leu Phe Pro Met Cys Pro Phe Gly Cys           
    65                  70                  75                            

cag tgc tat tca cga gtt gta cat tgc tca gat tta ggt ttg acc tca        529
Gln Cys Tyr Ser Arg Val Val His Cys Ser Asp Leu Gly Leu Thr Ser           
80                  85                  90                  95            

gtc cca acc aac att cca ttt gat act cga atg ctt gat ctt caa aac        577
Val Pro Thr Asn Ile Pro Phe Asp Thr Arg Met Leu Asp Leu Gln Asn           
                100                 105                 110               

aat aaa att aag gaa atc aaa gaa aat gat ttt aaa gga ctc act tca        625
Asn Lys Ile Lys Glu Ile Lys Glu Asn Asp Phe Lys Gly Leu Thr Ser           
            115                 120                 125                   

ctt tat ggt ctg atc ctg aac aac aac aag cta acg aag att cac cca        673
Leu Tyr Gly Leu Ile Leu Asn Asn Asn Lys Leu Thr Lys Ile His Pro           
        130                 135                 140                       

aaa gcc ttt cta acc aca aag aag ttg cga agg ctg tat ctg tcc cac        721
Lys Ala Phe Leu Thr Thr Lys Lys Leu Arg Arg Leu Tyr Leu Ser His           
    145                 150                 155                           

aat caa cta agt gaa ata cca ctt aat ctt ccc aaa tca tta gca gaa        769
Asn Gln Leu Ser Glu Ile Pro Leu Asn Leu Pro Lys Ser Leu Ala Glu           
160                 165                 170                 175           

ctc aga att cat gaa aat aaa gtt aag aaa ata caa aag gac aca ttc        817
Leu Arg Ile His Glu Asn Lys Val Lys Lys Ile Gln Lys Asp Thr Phe           
                180                 185                 190               

aaa gga atg aat gct tta cac gtt ttg gaa atg agt gca aac cct ctt        865
Lys Gly Met Asn Ala Leu His Val Leu Glu Met Ser Ala Asn Pro Leu           
            195                 200                 205                   

gat aat aat ggg ata gag cca ggg gca ttt gaa ggg gtg acg gtg ttc        913
Asp Asn Asn Gly Ile Glu Pro Gly Ala Phe Glu Gly Val Thr Val Phe           
        210                 215                 220                       

cat atc aga att gca gaa gca aaa ctg acc tca gtt cct aaa ggc tta        961
His Ile Arg Ile Ala Glu Ala Lys Leu Thr Ser Val Pro Lys Gly Leu           
    225                 230                 235                           

cca cca act tta ttg gag ctt cac tta gat tat aat aaa att tca aca       1009
Pro Pro Thr Leu Leu Glu Leu His Leu Asp Tyr Asn Lys Ile Ser Thr           
240                 245                 250                 255           

gtg gaa ctt gag gat ttt aaa cga tac aaa gaa cta caa agg ctg ggc       1057
Val Glu Leu Glu Asp Phe Lys Arg Tyr Lys Glu Leu Gln Arg Leu Gly           
                260                 265                 270               

cta gga aac aac aaa atc aca gat atc gaa aat ggg agt ctt gct aac       1105
Leu Gly Asn Asn Lys Ile Thr Asp Ile Glu Asn Gly Ser Leu Ala Asn           
            275                 280                 285                   

ata cca cgt gtg aga gaa ata cat ttg gaa aac aat aaa cta aaa aaa       1153
Ile Pro Arg Val Arg Glu Ile His Leu Glu Asn Asn Lys Leu Lys Lys           
        290                 295                 300                       

atc cct tca gga tta cca gag ttg aaa tac ctc cag ata atc ttc ctt       1201
Ile Pro Ser Gly Leu Pro Glu Leu Lys Tyr Leu Gln Ile Ile Phe Leu           
    305                 310                 315                           

cat tct aat tca att gca aga gtg gga gta aat gac ttc tgt cca aca       1249
His Ser Asn Ser Ile Ala Arg Val Gly Val Asn Asp Phe Cys Pro Thr           
320                 325                 330                 335           

gtg cca aag atg aag aaa tct tta tac agt gca ata agt tta ttc aac       1297
Val Pro Lys Met Lys Lys Ser Leu Tyr Ser Ala Ile Ser Leu Phe Asn           
                340                 345                 350               

aac ccg gtg aaa tac tgg gaa atg caa cct gca aca ttt cgt tgt gtt       1345
Asn Pro Val Lys Tyr Trp Glu Met Gln Pro Ala Thr Phe Arg Cys Val           
            355                 360                 365                   

ttg agc aga atg agt gtt cag ctt ggg aac ttt gga atg taa               1387
Leu Ser Arg Met Ser Val Gln Leu Gly Asn Phe Gly Met                       
        370                 375                 380                       

taattagtaa ttggtaatgt ccatttaata taagattcaa aaatccctac atttggaata     1447

cttgaactct attaataatg gtagtattat atatacaagc aaatatctat tctcaagtgg     1507

taagtccact gacttatttt atgacaagaa atttcaacgg aattttgcca aactattgat     1567

acataagggt tgagagaaac aagcatctat tgcagtttct ttttgcgtac aaatgatctt     1627

acataaatct catgcttgac cattcctttc ttcataacaa aaaagtaaga tattcggtat     1687

ttaacacttt gttatcaagc atattttaaa aagaactgta ctgtaaatgg aatgcttgac     1747

ttagcaaaat ttgtgctctt tcatttgctg ttagaaaaac agaattaaca aagacagtaa     1807

tgtgaagagt gcattacact attcttattc tttagtaact tgggtagtac tgtaatattt     1867

ttaatcatct taaagtatga tttgatataa tcttattgaa attaccttat catgtcttag     1927

agcccgtctt tatgtttaaa actaatttct taaaataaag ccttcagtaa atgttcatta     1987

ccaacttgat aaatgctact cataagagct ggtttggggc tatagcatat gctttttttt     2047

ttttaattat tacctgattt aaaaatctct gtaaaaacgt gtagtgtttc ataaaatctg     2107

taactcgcat tttaatgatc cgctattata agcttttaat agcatgaaaa ttgttaggct     2167

atataacatt gccacttcaa ctctaaggaa tatttttgag atatcccttt ggaagacctt     2227

gcttggaaga gcctggacac taacaattct acaccaaatt gtctcttcaa atacgtatgg     2287

actggataac tctgagaaac acatctagta taactgaata agcagagcat caaattaaac     2347

agacagaaac cgaaagctct atataaatgc tcagagttct ttatgtattt cttattggca     2407

ttcaacatat gtaaaatcag aaaacaggga aattttcatt aaaaatattg gtttgaaata     2467

aaaaaaaaaa aaa                                                        2480


<210>  828
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  828

Met Lys Glu Tyr Val Leu Leu Leu Phe Leu Ala Leu Cys Ser Ala Lys 
1               5                   10                  15      


Pro Phe Phe Ser Pro Ser His Ile Ala Leu Lys Asn Met Met Leu Lys 
            20                  25                  30          


Asp Met Glu Asp Thr Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
        35                  40                  45              


Asp Asp Asp Glu Asp Asn Ser Leu Phe Pro Thr Arg Glu Pro Arg Ser 
    50                  55                  60                  


His Phe Phe Pro Phe Asp Leu Phe Pro Met Cys Pro Phe Gly Cys Gln 
65                  70                  75                  80  


Cys Tyr Ser Arg Val Val His Cys Ser Asp Leu Gly Leu Thr Ser Val 
                85                  90                  95      


Pro Thr Asn Ile Pro Phe Asp Thr Arg Met Leu Asp Leu Gln Asn Asn 
            100                 105                 110         


Lys Ile Lys Glu Ile Lys Glu Asn Asp Phe Lys Gly Leu Thr Ser Leu 
        115                 120                 125             


Tyr Gly Leu Ile Leu Asn Asn Asn Lys Leu Thr Lys Ile His Pro Lys 
    130                 135                 140                 


Ala Phe Leu Thr Thr Lys Lys Leu Arg Arg Leu Tyr Leu Ser His Asn 
145                 150                 155                 160 


Gln Leu Ser Glu Ile Pro Leu Asn Leu Pro Lys Ser Leu Ala Glu Leu 
                165                 170                 175     


Arg Ile His Glu Asn Lys Val Lys Lys Ile Gln Lys Asp Thr Phe Lys 
            180                 185                 190         


Gly Met Asn Ala Leu His Val Leu Glu Met Ser Ala Asn Pro Leu Asp 
        195                 200                 205             


Asn Asn Gly Ile Glu Pro Gly Ala Phe Glu Gly Val Thr Val Phe His 
    210                 215                 220                 


Ile Arg Ile Ala Glu Ala Lys Leu Thr Ser Val Pro Lys Gly Leu Pro 
225                 230                 235                 240 


Pro Thr Leu Leu Glu Leu His Leu Asp Tyr Asn Lys Ile Ser Thr Val 
                245                 250                 255     


Glu Leu Glu Asp Phe Lys Arg Tyr Lys Glu Leu Gln Arg Leu Gly Leu 
            260                 265                 270         


Gly Asn Asn Lys Ile Thr Asp Ile Glu Asn Gly Ser Leu Ala Asn Ile 
        275                 280                 285             


Pro Arg Val Arg Glu Ile His Leu Glu Asn Asn Lys Leu Lys Lys Ile 
    290                 295                 300                 


Pro Ser Gly Leu Pro Glu Leu Lys Tyr Leu Gln Ile Ile Phe Leu His 
305                 310                 315                 320 


Ser Asn Ser Ile Ala Arg Val Gly Val Asn Asp Phe Cys Pro Thr Val 
                325                 330                 335     


Pro Lys Met Lys Lys Ser Leu Tyr Ser Ala Ile Ser Leu Phe Asn Asn 
            340                 345                 350         


Pro Val Lys Tyr Trp Glu Met Gln Pro Ala Thr Phe Arg Cys Val Leu 
        355                 360                 365             


Ser Arg Met Ser Val Gln Leu Gly Asn Phe Gly Met 
    370                 375                 380 


<210>  829
<211>  3248
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (121)..(1737)

<400>  829
ctagaggcag ctcagataga ggagctcttt gggaagagac gccgggcagg cagaagcagc       60

aggtaccccc tccacatccc tagggctctg tgatgtaggc agaggcccgt gggagtcagc      120

atg ccg cgt ggc tgg gcc gcc ccc ttg ctc ctg ctg ctg ctc cag gga        168
Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly           
1               5                   10                  15                

ggc tgg ggc tgc ccc gac ctc gtc tgc tac acc gat tac ctc cag acg        216
Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr           
            20                  25                  30                    

gtc atc tgc atc ctg gaa atg tgg aac ctc cac ccc agc acg ctc acc        264
Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr           
        35                  40                  45                        

ctt acc tgg caa gac cag tat gaa gag ctg aag gac gag gcc acc tcc        312
Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser           
    50                  55                  60                            

tgc agc ctc cac agg tcg gcc cac aat gcc acg cat gcc acc tac acc        360
Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr           
65                  70                  75                  80            

tgc cac atg gat gta ttc cac ttc atg gcc gac gac att ttc agt gtc        408
Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val           
                85                  90                  95                

aac atc aca gac cag tct ggc aac tac tcc cag gag tgt ggc agc ttt        456
Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe           
            100                 105                 110                   

ctc ctg gct gag agc atc aag ccg gct ccc cct ttc aac gtg act gtg        504
Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val           
        115                 120                 125                       

acc ttc tca gga cag tat aat atc tcc tgg cgc tca gat tac gaa gac        552
Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp           
    130                 135                 140                           

cct gcc ttc tac atg ctg aag ggc aag ctt cag tat gag ctg cag tac        600
Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr           
145                 150                 155                 160           

agg aac cgg gga gac ccc tgg gct gtg agt ccg agg aga aag ctg atc        648
Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile           
                165                 170                 175               

tca gtg gac tca aga agt gtc tcc ctc ctc ccc ctg gag ttc cgc aaa        696
Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys           
            180                 185                 190                   

gac tcg agc tat gag ctg cag gtg cgg gca ggg ccc atg cct ggc tcc        744
Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser           
        195                 200                 205                       

tcc tac cag ggg acc tgg agt gaa tgg agt gac ccg gtc atc ttt cag        792
Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln           
    210                 215                 220                           

acc cag tca gag gag tta aag gaa ggc tgg aac cct cac ctg ctg ctt        840
Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu           
225                 230                 235                 240           

ctc ctc ctg ctt gtc ata gtc ttc att cct gcc ttc tgg agc ctg aag        888
Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys           
                245                 250                 255               

acc cat cca ttg tgg agg cta tgg aag aag ata tgg gcc gtc ccc agc        936
Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser           
            260                 265                 270                   

cct gag cgg ttc ttc atg ccc ctg tac aag ggc tgc agc gga gac ttc        984
Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe           
        275                 280                 285                       

aag aaa tgg gtg ggt gca ccc ttc act ggc tcc agc ctg gag ctg gga       1032
Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly           
    290                 295                 300                           

ccc tgg agc cca gag gtg ccc tcc acc ctg gag gtg tac agc tgc cac       1080
Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His           
305                 310                 315                 320           

cca cca cgg agc ccg gcc aag agg ctg cag ctc acg gag cta caa gaa       1128
Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu           
                325                 330                 335               

cca gca gag ctg gtg gag tct gac ggt gtg ccc aag ccc agc ttc tgg       1176
Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp           
            340                 345                 350                   

ccg aca gcc cag aac tcg ggg ggc tca gct tac agt gag gag agg gat       1224
Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp           
        355                 360                 365                       

cgg cca tac ggc ctg gtg tcc att gac aca gtg act gtg cta gat gca       1272
Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala           
    370                 375                 380                           

gag ggg cca tgc acc tgg ccc tgc agc tgt gag gat gac ggc tac cca       1320
Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro           
385                 390                 395                 400           

gcc ctg gac ctg gat gct ggc ctg gag ccc agc cca ggc cta gag gac       1368
Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp           
                405                 410                 415               

cca ctc ttg gat gca ggg acc aca gtc ctg tcc tgt ggc tgt gtc tca       1416
Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser           
            420                 425                 430                   

gct ggc agc cct ggg cta gga ggg ccc ctg gga agc ctc ctg gac aga       1464
Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg           
        435                 440                 445                       

cta aag cca ccc ctt gca gat ggg gag gac tgg gct ggg gga ctg ccc       1512
Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro           
    450                 455                 460                           

tgg ggt ggc cgg tca cct gga ggg gtc tca gag agt gag gcg ggc tca       1560
Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser           
465                 470                 475                 480           

ccc ctg gcc ggc ctg gat atg gac acg ttt gac agt ggc ttt gtg ggc       1608
Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly           
                485                 490                 495               

tct gac tgc agc agc cct gtg gag tgt gac ttc acc agc ccc ggg gac       1656
Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp           
            500                 505                 510                   

gaa gga ccc ccc cgg agc tac ctc cgc cag tgg gtg gtc att cct ccg       1704
Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro           
        515                 520                 525                       

cca ctt tcg agc cct gga ccc cag gcc agc taa tgaggctgac tggatgtcca     1757
Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser                                   
    530                 535                                               

gagctggcca ggccactggg ccctgagcca gagacaaggt cacctgggct gtgatgtgaa     1817

gacacctgca gcctttggtc tcctggatgg gcctttgagc ctgatgttta cagtgtctgt     1877

gtgtgtgtgt gcatatgtgt gtgtgtgcat atgcatgtgt gtgtgtgtgt gtgtcttagg     1937

tgcgcagtgg catgtccacg tgtgtgtgtg attgcacgtg cctgtgggcc tgggataatg     1997

cccatggtac tccatgcatt cacctgccct gtgcatgtct ggactcacgg agctcaccca     2057

tgtgcacaag tgtgcacagt aaacgtgttt gtggtcaaca gatgacaaca gccgtcctcc     2117

ctcctagggt cttgtgttgc aagttggtcc acagcatctc cggggctttg tgggatcagg     2177

gcattgcctg tgactgaggc ggagcccagc cctccagcgt ctgcctccag gagctgcaag     2237

aagtccatat tgttccttat cacctgccaa caggaagcga aaggggatgg agtgagccca     2297

tggtgacctc gggaatggca attttttggg cggcccctgg acgaaggtct gaatcccgac     2357

tctgatacct tctggctgtg ctacctgagc caagtcgcct cccctctctg ggctagagtt     2417

tccttatcca gacagtgggg aaggcatgac acacctgggg gaaattggcg atgtcacccg     2477

tgtacggtac gcagcccaga gcagaccctc aataaacgtc agcttccttc cttctgcggc     2537

cagagccgag gcgggcgggg gtgagaacat caatcgtcag cgacagcctg ggcacccgcg     2597

gggccgtccc gcctgcagag ggccactcgg gggggtttcc aggcttaaaa tcagtccgtt     2657

tcgtctcttg gaaacagctc cccaccaacc aagatttctt tttctaactt ctgctactaa     2717

gtttttaaaa attcccttta tgcacccaag agatatttat taaacaccaa ttacgtagca     2777

ggccatggct catgggaccc accccccgtg gcactcatgg agggggctgc aggttggaac     2837

tatgcagtgt gctccggcca cacatcctgc tgggccccct accctgcccc aattcaatcc     2897

tgccaataaa tcctgtctta tttgttcatc ctggagaatt gaagggaggt caagttgttt     2957

gtcaatgatt tgtcagagaa cctgttgaaa tgtgaattaa gaagctaaga aaatatttct     3017

tagcaacatt ttctttttct tttttttttt tttcttttga gacagagtct cactctcgtc     3077

gcccaggctg gaatgcagtg gtgcgatctc ggctctctgc aacctctgtc tcccgggttc     3137

aagcgatttc ctgcgtcagc cccagagtag ctggaattac aggcacacac caccacgcct     3197

ggctaatttt tgtattttta gtagagctgg ggccaccctg gcccggcccc g              3248


<210>  830
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  830

Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly 
1               5                   10                  15      


Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr 
            20                  25                  30          


Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr 
        35                  40                  45              


Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr 
65                  70                  75                  80  


Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val 
                85                  90                  95      


Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val 
        115                 120                 125             


Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp 
    130                 135                 140                 


Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys 
            180                 185                 190         


Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser 
        195                 200                 205             


Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys 
                245                 250                 255     


Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser 
            260                 265                 270         


Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe 
        275                 280                 285             


Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly 
    290                 295                 300                 


Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His 
305                 310                 315                 320 


Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu 
                325                 330                 335     


Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp 
            340                 345                 350         


Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp 
        355                 360                 365             


Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 
    370                 375                 380                 


Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro 
385                 390                 395                 400 


Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp 
                405                 410                 415     


Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser 
            420                 425                 430         


Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg 
        435                 440                 445             


Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro 
    450                 455                 460                 


Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser 
465                 470                 475                 480 


Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 
                485                 490                 495     


Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 
            500                 505                 510         


Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 
        515                 520                 525             


Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    530                 535             


<210>  831
<211>  7477
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(5229)

<400>  831
atg tgg ccg gcc ggc gcg ggc acc aag ctg ccc tgt ccc cga gac tct         48
Met Trp Pro Ala Gly Ala Gly Thr Lys Leu Pro Cys Pro Arg Asp Ser           
1               5                   10                  15                

gcg ctc cgg cgg gcg gct ttc tct ggg aac ctc acg gcc ctg ccc tct         96
Ala Leu Arg Arg Ala Ala Phe Ser Gly Asn Leu Thr Ala Leu Pro Ser           
            20                  25                  30                    

cac ctc gtg ccc gcc ggc cgc agc gtc cgg gtc ttc atc agc gcc aac        144
His Leu Val Pro Ala Gly Arg Ser Val Arg Val Phe Ile Ser Ala Asn           
        35                  40                  45                        

cct gaa gat acg gga gca gaa aga cag gcg cta aga gaa aat gta tat        192
Pro Glu Asp Thr Gly Ala Glu Arg Gln Ala Leu Arg Glu Asn Val Tyr           
    50                  55                  60                            

cct aaa ctg aga gaa ttc tgc aga gaa aac tat gga ttg gaa ttt cag        240
Pro Lys Leu Arg Glu Phe Cys Arg Glu Asn Tyr Gly Leu Glu Phe Gln           
65                  70                  75                  80            

gtc ata gat ctg tac tgg gga gtg gaa gaa gat gag tgg gac agc cca        288
Val Ile Asp Leu Tyr Trp Gly Val Glu Glu Asp Glu Trp Asp Ser Pro           
                85                  90                  95                

gag ctc cag aag acc cgc atg aag ctg ctg gag aat tgc ttg aaa act        336
Glu Leu Gln Lys Thr Arg Met Lys Leu Leu Glu Asn Cys Leu Lys Thr           
            100                 105                 110                   

tct gca ggt cca tgt ttt gtt gga cta tta ggt gaa aaa tat ggg aat        384
Ser Ala Gly Pro Cys Phe Val Gly Leu Leu Gly Glu Lys Tyr Gly Asn           
        115                 120                 125                       

atc cga atc cct gga gaa gtt gaa gcc tca gag ttt gaa atg att ttg        432
Ile Arg Ile Pro Gly Glu Val Glu Ala Ser Glu Phe Glu Met Ile Leu           
    130                 135                 140                           

gat gcc gcc ata gag gca aag ctg gag acc aag ttg ctg gag gag tgg        480
Asp Ala Ala Ile Glu Ala Lys Leu Glu Thr Lys Leu Leu Glu Glu Trp           
145                 150                 155                 160           

tac tgt cga gat gag aac tcg gtg cca gca gcc tat tac ctc aga ccc        528
Tyr Cys Arg Asp Glu Asn Ser Val Pro Ala Ala Tyr Tyr Leu Arg Pro           
                165                 170                 175               

aag tca gaa atg ctg aga agc aat aga aat gca atg cag cct tct acc        576
Lys Ser Glu Met Leu Arg Ser Asn Arg Asn Ala Met Gln Pro Ser Thr           
            180                 185                 190                   

aat gct gaa aac gag aag aca tgg caa gag ata tca gat gag atc aag        624
Asn Ala Glu Asn Glu Lys Thr Trp Gln Glu Ile Ser Asp Glu Ile Lys           
        195                 200                 205                       

aag ata ttt aag gct gct gta aag ctg tta cac gaa aag ggt aaa atg        672
Lys Ile Phe Lys Ala Ala Val Lys Leu Leu His Glu Lys Gly Lys Met           
    210                 215                 220                           

aaa cac agc cag gct aag agg tac ctg ttc tca gct ata gag gat gag        720
Lys His Ser Gln Ala Lys Arg Tyr Leu Phe Ser Ala Ile Glu Asp Glu           
225                 230                 235                 240           

ttt gac ttt gct ctg gga aaa caa act cca gca ttt cta aag aag tgt        768
Phe Asp Phe Ala Leu Gly Lys Gln Thr Pro Ala Phe Leu Lys Lys Cys           
                245                 250                 255               

gtt tgc tac att agg aaa att gct aac att gag cgc ttt gtg aaa atc        816
Val Cys Tyr Ile Arg Lys Ile Ala Asn Ile Glu Arg Phe Val Lys Ile           
            260                 265                 270                   

cca gag atg gga aaa tac atg gat ata act gga aca gaa ccg agg att        864
Pro Glu Met Gly Lys Tyr Met Asp Ile Thr Gly Thr Glu Pro Arg Ile           
        275                 280                 285                       

att cgg gac cca gaa gcc caa gag aag ctg ata aaa ctc agg gat gaa        912
Ile Arg Asp Pro Glu Ala Gln Glu Lys Leu Ile Lys Leu Arg Asp Glu           
    290                 295                 300                           

ttt att cct act att gtt gca tca tct aat ctg aga gtg tac aca tct        960
Phe Ile Pro Thr Ile Val Ala Ser Ser Asn Leu Arg Val Tyr Thr Ser           
305                 310                 315                 320           

gtt act cat tgt gac atg aaa cta ggc tac tcc caa gaa ata gaa aat       1008
Val Thr His Cys Asp Met Lys Leu Gly Tyr Ser Gln Glu Ile Glu Asn           
                325                 330                 335               

cat tac atc gaa gga ctt ggt aaa caa ttt tat gag gac atg att gat       1056
His Tyr Ile Glu Gly Leu Gly Lys Gln Phe Tyr Glu Asp Met Ile Asp           
            340                 345                 350                   

ata att cag gca acg ata caa cag aat ttt gac act gaa act gat aca       1104
Ile Ile Gln Ala Thr Ile Gln Gln Asn Phe Asp Thr Glu Thr Asp Thr           
        355                 360                 365                       

ctc tat gat gaa atc ctt caa cat tca tca tta tgt aaa aca tac gcc       1152
Leu Tyr Asp Glu Ile Leu Gln His Ser Ser Leu Cys Lys Thr Tyr Ala           
    370                 375                 380                           

tcc ttc tat gag tac aaa tgt gaa tct cta aac ata gtg cat aac tac       1200
Ser Phe Tyr Glu Tyr Lys Cys Glu Ser Leu Asn Ile Val His Asn Tyr           
385                 390                 395                 400           

att ctt cca agc aaa gct gga cac atc aac cct ctt att ata tat ggt       1248
Ile Leu Pro Ser Lys Ala Gly His Ile Asn Pro Leu Ile Ile Tyr Gly           
                405                 410                 415               

ggg cca tgc act ggg aag acc ctt ctg cta gct gaa gta gca aag aag       1296
Gly Pro Cys Thr Gly Lys Thr Leu Leu Leu Ala Glu Val Ala Lys Lys           
            420                 425                 430                   

gct tat ggc tgg cta cat gag gac aca gga cca gaa tct gac cca gta       1344
Ala Tyr Gly Trp Leu His Glu Asp Thr Gly Pro Glu Ser Asp Pro Val           
        435                 440                 445                       

gtc atc gtg aga ttt cta gga acg aca gac atg agc tct gac ctt agg       1392
Val Ile Val Arg Phe Leu Gly Thr Thr Asp Met Ser Ser Asp Leu Arg           
    450                 455                 460                           

act ctc ctt cta agt gtt tgt gaa caa ttg gca gtt aac tac cgg tgt       1440
Thr Leu Leu Leu Ser Val Cys Glu Gln Leu Ala Val Asn Tyr Arg Cys           
465                 470                 475                 480           

ctg gtt caa agc tac cct aag aag atc cat gac ctc tgt gac tta ttt       1488
Leu Val Gln Ser Tyr Pro Lys Lys Ile His Asp Leu Cys Asp Leu Phe           
                485                 490                 495               

ata aat ctt ttg aat gag tct tca ctg cag aga cct cta gtc ata ata       1536
Ile Asn Leu Leu Asn Glu Ser Ser Leu Gln Arg Pro Leu Val Ile Ile           
            500                 505                 510                   

ttc gat gca cta gag cag ctc tca gag aat gat gat gcc agg aag ctt       1584
Phe Asp Ala Leu Glu Gln Leu Ser Glu Asn Asp Asp Ala Arg Lys Leu           
        515                 520                 525                       

tgg tgg ctc cca gct cac ctg ccc cgc ttt gtc cgg ata gtc ctt tcc       1632
Trp Trp Leu Pro Ala His Leu Pro Arg Phe Val Arg Ile Val Leu Ser           
    530                 535                 540                           

acg ctg ccc aac aaa cat ggg atc ttg cag aaa cta agg tgc ctt atc       1680
Thr Leu Pro Asn Lys His Gly Ile Leu Gln Lys Leu Arg Cys Leu Ile           
545                 550                 555                 560           

cat gaa gaa gac aac tac atc gag ctg att ccc cga gac agg aag atg       1728
His Glu Glu Asp Asn Tyr Ile Glu Leu Ile Pro Arg Asp Arg Lys Met           
                565                 570                 575               

tgc agc cag gtc ctc aaa cac cag ctg ctg cgc gtc aaa agg aag gtc       1776
Cys Ser Gln Val Leu Lys His Gln Leu Leu Arg Val Lys Arg Lys Val           
            580                 585                 590                   

aca tca ggc cag cag att tat gtg aac aat gca tta tcc aag tgc aca       1824
Thr Ser Gly Gln Gln Ile Tyr Val Asn Asn Ala Leu Ser Lys Cys Thr           
        595                 600                 605                       

ctg cca atg ttt gtg aac ctg acc ttc agg gag gtg agg cac tgg aga       1872
Leu Pro Met Phe Val Asn Leu Thr Phe Arg Glu Val Arg His Trp Arg           
    610                 615                 620                           

tct cac aaa gac gtc gat gaa tcc tcc ctc tct gtc acc gtt cat gaa       1920
Ser His Lys Asp Val Asp Glu Ser Ser Leu Ser Val Thr Val His Glu           
625                 630                 635                 640           

agt ata gag cag tta ttc tgg tcc ttg gag aag aag tgt ggt cag aaa       1968
Ser Ile Glu Gln Leu Phe Trp Ser Leu Glu Lys Lys Cys Gly Gln Lys           
                645                 650                 655               

ctg gtc tct agg gct ctt ggt tac atc acc atg gcc aaa atg ggt ctg       2016
Leu Val Ser Arg Ala Leu Gly Tyr Ile Thr Met Ala Lys Met Gly Leu           
            660                 665                 670                   

agt gaa atg gaa ctg gag gat gtg tta gcc cta gac aac agt gta atg       2064
Ser Glu Met Glu Leu Glu Asp Val Leu Ala Leu Asp Asn Ser Val Met           
        675                 680                 685                       

agt gag ctc aaa gaa aac acc aga ccc agc aat ccc ctg aga gta cct       2112
Ser Glu Leu Lys Glu Asn Thr Arg Pro Ser Asn Pro Leu Arg Val Pro           
    690                 695                 700                           

tac ttg tac att gca agg ctc aag gag ggt ctc agt gga tac cta ata       2160
Tyr Leu Tyr Ile Ala Arg Leu Lys Glu Gly Leu Ser Gly Tyr Leu Ile           
705                 710                 715                 720           

gaa aga cat gtg aaa aat gtc aca ctc cta gtc tgg gcc aac aga cac       2208
Glu Arg His Val Lys Asn Val Thr Leu Leu Val Trp Ala Asn Arg His           
                725                 730                 735               

ctg cag ctc ata gcc cag aag cta tat ctg cag gat gac aat gac ctg       2256
Leu Gln Leu Ile Ala Gln Lys Leu Tyr Leu Gln Asp Asp Asn Asp Leu           
            740                 745                 750                   

cgt gaa atg cac acc atc tta gca gat tat ttt ctg ggg gtt tgg tca       2304
Arg Glu Met His Thr Ile Leu Ala Asp Tyr Phe Leu Gly Val Trp Ser           
        755                 760                 765                       

ggg ggc agg agg aaa gcc ttc tgc ctt gag gac ccc tac ttg aat ggc       2352
Gly Gly Arg Arg Lys Ala Phe Cys Leu Glu Asp Pro Tyr Leu Asn Gly           
    770                 775                 780                           

tgc ctt gac ttg gag aac aga agt ttg ctg gag gaa gaa aag cac ttc       2400
Cys Leu Asp Leu Glu Asn Arg Ser Leu Leu Glu Glu Glu Lys His Phe           
785                 790                 795                 800           

atg gaa cag gct tcc ttt gac agg cag gct cca gac cag ccc tgg gtt       2448
Met Glu Gln Ala Ser Phe Asp Arg Gln Ala Pro Asp Gln Pro Trp Val           
                805                 810                 815               

ttc cag tgt aat ccc ctg gaa cct gac atc ttt ttc gtt aat cat cgg       2496
Phe Gln Cys Asn Pro Leu Glu Pro Asp Ile Phe Phe Val Asn His Arg           
            820                 825                 830                   

aaa atg tct gag ctg ttg tac cac ttg acg agg tgt gga aaa acc gat       2544
Lys Met Ser Glu Leu Leu Tyr His Leu Thr Arg Cys Gly Lys Thr Asp           
        835                 840                 845                       

gac ctg ctt tac ggc atc atc atg aac ttc agc tgg ctt tat acc atg       2592
Asp Leu Leu Tyr Gly Ile Ile Met Asn Phe Ser Trp Leu Tyr Thr Met           
    850                 855                 860                           

atc aaa att ggc cag ttt gac aaa gtg ctt tca gac att gag ctg gct       2640
Ile Lys Ile Gly Gln Phe Asp Lys Val Leu Ser Asp Ile Glu Leu Ala           
865                 870                 875                 880           

tac aac tac tcg caa gag aag gag ctg aag ttc ctg gcc aac acc ctc       2688
Tyr Asn Tyr Ser Gln Glu Lys Glu Leu Lys Phe Leu Ala Asn Thr Leu           
                885                 890                 895               

cgc agc atc aaa aac aag gtc act gca ttt ccc ggc tcc ctt tca gca       2736
Arg Ser Ile Lys Asn Lys Val Thr Ala Phe Pro Gly Ser Leu Ser Ala           
            900                 905                 910                   

gag ctt cag caa aga ctg ctg cct gtt gta agc tcc ctg ccc aaa ctt       2784
Glu Leu Gln Gln Arg Leu Leu Pro Val Val Ser Ser Leu Pro Lys Leu           
        915                 920                 925                       

aga cat ctt ctt tta gag tgt gat aaa gat ggg ccc aaa tat tgc tcc       2832
Arg His Leu Leu Leu Glu Cys Asp Lys Asp Gly Pro Lys Tyr Cys Ser           
    930                 935                 940                           

att gta cca ctg cat tca tcc atg gat gtg aca tac agc cca gag cgt       2880
Ile Val Pro Leu His Ser Ser Met Asp Val Thr Tyr Ser Pro Glu Arg           
945                 950                 955                 960           

ctt ccc tta tca tcc agt cac ctg cat gtc aca gag atc ctg cct acc       2928
Leu Pro Leu Ser Ser Ser His Leu His Val Thr Glu Ile Leu Pro Thr           
                965                 970                 975               

tgt aac ccc agc act gtc ctc aca gct tta gaa aat ggt tcc atc agc       2976
Cys Asn Pro Ser Thr Val Leu Thr Ala Leu Glu Asn Gly Ser Ile Ser           
            980                 985                 990                   

acc tgg gat gta gag act cga cag  cta ctc agg caa atc  acc aca gcc     3024
Thr Trp Asp Val Glu Thr Arg Gln  Leu Leu Arg Gln Ile  Thr Thr Ala         
        995                 1000                 1005                     

cag tct  gtc atc ctg ggc atg  aaa ctc acc agt gat  gaa aag tac        3069
Gln Ser  Val Ile Leu Gly Met  Lys Leu Thr Ser Asp  Glu Lys Tyr            
    1010                 1015                 1020                        

ctt gtg  gtg gct aca aca aat  aac acc ttg ttg att  tat gac aat        3114
Leu Val  Val Ala Thr Thr Asn  Asn Thr Leu Leu Ile  Tyr Asp Asn            
    1025                 1030                 1035                        

gtc aat  tct tgc ctc ctg tct  gaa gta gaa atc aag  ggg acc aag        3159
Val Asn  Ser Cys Leu Leu Ser  Glu Val Glu Ile Lys  Gly Thr Lys            
    1040                 1045                 1050                        

cat gga  agc agc gcc acc tac  atc aat gga ttt aca  ctg tcc gcc        3204
His Gly  Ser Ser Ala Thr Tyr  Ile Asn Gly Phe Thr  Leu Ser Ala            
    1055                 1060                 1065                        

aac cac  gcc ctt gca tgg ctc  gaa gcc agc aaa gat  gtc act gtc        3249
Asn His  Ala Leu Ala Trp Leu  Glu Ala Ser Lys Asp  Val Thr Val            
    1070                 1075                 1080                        

atc gat  ctg ctg tac gga tgg  ccg ctt tac cag ttc  cac tgc tgg        3294
Ile Asp  Leu Leu Tyr Gly Trp  Pro Leu Tyr Gln Phe  His Cys Trp            
    1085                 1090                 1095                        

tat gaa  gtg acg tgc gtc cag  tgc tcc ctg gat ggt  ctg tat gct        3339
Tyr Glu  Val Thr Cys Val Gln  Cys Ser Leu Asp Gly  Leu Tyr Ala            
    1100                 1105                 1110                        

ttc tgt  ggc caa tac ctg aac  aca acc acc ata ttt  cat tta ggg        3384
Phe Cys  Gly Gln Tyr Leu Asn  Thr Thr Thr Ile Phe  His Leu Gly            
    1115                 1120                 1125                        

agt gga  gaa aag tta tgt aca  gtg aca tca gaa ttt  tca ggt gga        3429
Ser Gly  Glu Lys Leu Cys Thr  Val Thr Ser Glu Phe  Ser Gly Gly            
    1130                 1135                 1140                        

ttt gtg  aag ttt ctt ctt atc  ttg gac aca gct cag  gaa atg gtc        3474
Phe Val  Lys Phe Leu Leu Ile  Leu Asp Thr Ala Gln  Glu Met Val            
    1145                 1150                 1155                        

atg gta  gac agt gaa gga agt  ctt tct gtt tgg aat  act gag gac        3519
Met Val  Asp Ser Glu Gly Ser  Leu Ser Val Trp Asn  Thr Glu Asp            
    1160                 1165                 1170                        

att tcc  agc ccc cag ctg act  gat gac ttt gat tgc  cga aga gaa        3564
Ile Ser  Ser Pro Gln Leu Thr  Asp Asp Phe Asp Cys  Arg Arg Glu            
    1175                 1180                 1185                        

gac agt  gag gtg gtc agc att  gag ctt tca gaa gac  caa agt gca        3609
Asp Ser  Glu Val Val Ser Ile  Glu Leu Ser Glu Asp  Gln Ser Ala            
    1190                 1195                 1200                        

gtt ctg  atc tgt aaa gcc ctc  agc att gag ctc tta  gat act ggt        3654
Val Leu  Ile Cys Lys Ala Leu  Ser Ile Glu Leu Leu  Asp Thr Gly            
    1205                 1210                 1215                        

ctg tgg  aag gtg gct gaa aag  ttc aga gcc aag cac  aac gaa cgc        3699
Leu Trp  Lys Val Ala Glu Lys  Phe Arg Ala Lys His  Asn Glu Arg            
    1220                 1225                 1230                        

ttt ata  tct gcc gtg ctg tct  aaa aat gga gat tgt  atc atc gcc        3744
Phe Ile  Ser Ala Val Leu Ser  Lys Asn Gly Asp Cys  Ile Ile Ala            
    1235                 1240                 1245                        

acc atg  gaa aat acc tca gct  gtg ttt ttt tgg agg  cgg gac aca        3789
Thr Met  Glu Asn Thr Ser Ala  Val Phe Phe Trp Arg  Arg Asp Thr            
    1250                 1255                 1260                        

gga cag  tgt atg gca agc ttg  cag gaa atc tca ggt  tcc att gtt        3834
Gly Gln  Cys Met Ala Ser Leu  Gln Glu Ile Ser Gly  Ser Ile Val            
    1265                 1270                 1275                        

aag tta  gtg aaa tcc agt cac  cac aat atg cta ctg  tct tta tca        3879
Lys Leu  Val Lys Ser Ser His  His Asn Met Leu Leu  Ser Leu Ser            
    1280                 1285                 1290                        

acc agt  ggt gtt ctt tcc att  tgg gac ata gat ata  atc aca gct        3924
Thr Ser  Gly Val Leu Ser Ile  Trp Asp Ile Asp Ile  Ile Thr Ala            
    1295                 1300                 1305                        

atg tcc  aac ata gat aag act  gga aaa ccc atc caa  agt ctg ttg        3969
Met Ser  Asn Ile Asp Lys Thr  Gly Lys Pro Ile Gln  Ser Leu Leu            
    1310                 1315                 1320                        

ttg cct  gct aga ggg gaa atc  att tac tcc ctg gat  gga tcc gat        4014
Leu Pro  Ala Arg Gly Glu Ile  Ile Tyr Ser Leu Asp  Gly Ser Asp            
    1325                 1330                 1335                        

tgt gtt  cat aag tgg aac ttc  agc agt ggc ttc atc  gaa gca gta        4059
Cys Val  His Lys Trp Asn Phe  Ser Ser Gly Phe Ile  Glu Ala Val            
    1340                 1345                 1350                        

ttc aag  cat gaa gga ata gtt  gaa cac tgt gtg tta  aca tcc acc        4104
Phe Lys  His Glu Gly Ile Val  Glu His Cys Val Leu  Thr Ser Thr            
    1355                 1360                 1365                        

gga gat  ata atg gtg aca tca  gat gac aaa agc agc  cag tat gtc        4149
Gly Asp  Ile Met Val Thr Ser  Asp Asp Lys Ser Ser  Gln Tyr Val            
    1370                 1375                 1380                        

tgg cac  acc agc agt ggt gaa  aac ctt ttt cga att  aac ggg cag        4194
Trp His  Thr Ser Ser Gly Glu  Asn Leu Phe Arg Ile  Asn Gly Gln            
    1385                 1390                 1395                        

aga ata  tct cag ctg ctg att  aca cac aat gac cag  ttt gtg gtc        4239
Arg Ile  Ser Gln Leu Leu Ile  Thr His Asn Asp Gln  Phe Val Val            
    1400                 1405                 1410                        

tcg ctc  tgt gag gaa aat gcc  tcc agg gtt tgg agg  ctc gcc aca        4284
Ser Leu  Cys Glu Glu Asn Ala  Ser Arg Val Trp Arg  Leu Ala Thr            
    1415                 1420                 1425                        

ggc cac  agg gtc tgc aac att  ctg acc act ttg cag  aat gcc ttt        4329
Gly His  Arg Val Cys Asn Ile  Leu Thr Thr Leu Gln  Asn Ala Phe            
    1430                 1435                 1440                        

att acc  tcc gca aat acc ttc  gtg gtg gga atg act  aaa agc aaa        4374
Ile Thr  Ser Ala Asn Thr Phe  Val Val Gly Met Thr  Lys Ser Lys            
    1445                 1450                 1455                        

gtg ttg  gca gtc agt ctt tgg  aca gga agt atc acc  aag aaa ttt        4419
Val Leu  Ala Val Ser Leu Trp  Thr Gly Ser Ile Thr  Lys Lys Phe            
    1460                 1465                 1470                        

tgc tgt  gaa gat ggg acc acc  atc gtg aat ttt aaa  tta atc cct        4464
Cys Cys  Glu Asp Gly Thr Thr  Ile Val Asn Phe Lys  Leu Ile Pro            
    1475                 1480                 1485                        

gac tgt  cct gat atc atc gtg  ttt atc aca tcg gcc  gag act gtg        4509
Asp Cys  Pro Asp Ile Ile Val  Phe Ile Thr Ser Ala  Glu Thr Val            
    1490                 1495                 1500                        

aac atc  tgg agt ctg aca gat  gaa gtg atc tgt cgg  cgc gtg caa        4554
Asn Ile  Trp Ser Leu Thr Asp  Glu Val Ile Cys Arg  Arg Val Gln            
    1505                 1510                 1515                        

ctt cca  aac aac ttc ttg aaa  aat ctg gag gac ttt  gaa att tct        4599
Leu Pro  Asn Asn Phe Leu Lys  Asn Leu Glu Asp Phe  Glu Ile Ser            
    1520                 1525                 1530                        

ccc aat  gga aag cta ggc att  ata gcc agg gga gat  gaa aac atc        4644
Pro Asn  Gly Lys Leu Gly Ile  Ile Ala Arg Gly Asp  Glu Asn Ile            
    1535                 1540                 1545                        

aat gtg  cta gat tta tac agt  ggt aaa ttg cgg gtg  gtt cac gcc        4689
Asn Val  Leu Asp Leu Tyr Ser  Gly Lys Leu Arg Val  Val His Ala            
    1550                 1555                 1560                        

tct ggg  atc atc tgg cgg cag  agg ttg tct cgg gat  ggt cgc tac        4734
Ser Gly  Ile Ile Trp Arg Gln  Arg Leu Ser Arg Asp  Gly Arg Tyr            
    1565                 1570                 1575                        

ctg gta  tac att tgt ttc cga  aat ggg gag gag gag  gat gaa aat        4779
Leu Val  Tyr Ile Cys Phe Arg  Asn Gly Glu Glu Glu  Asp Glu Asn            
    1580                 1585                 1590                        

ggt gca  ata ttc agt tta att  gta atg aga ctg gca  gat ggc aaa        4824
Gly Ala  Ile Phe Ser Leu Ile  Val Met Arg Leu Ala  Asp Gly Lys            
    1595                 1600                 1605                        

aat atc  ggt gct tgt tcc ctt  tac aaa aca cca act  ttc ctt gca        4869
Asn Ile  Gly Ala Cys Ser Leu  Tyr Lys Thr Pro Thr  Phe Leu Ala            
    1610                 1615                 1620                        

ctc tcc  cag agg cac ctg aac  atc att gtg ggc ttt  gat gat ggg        4914
Leu Ser  Gln Arg His Leu Asn  Ile Ile Val Gly Phe  Asp Asp Gly            
    1625                 1630                 1635                        

agt ata  ggg atc tac acg gta  gta gac cgt gta gat  gct gca ctg        4959
Ser Ile  Gly Ile Tyr Thr Val  Val Asp Arg Val Asp  Ala Ala Leu            
    1640                 1645                 1650                        

aaa atc  aaa att gcc act tca  aat agc aga caa att  ttc aac aat        5004
Lys Ile  Lys Ile Ala Thr Ser  Asn Ser Arg Gln Ile  Phe Asn Asn            
    1655                 1660                 1665                        

gca aca  cac acc tcc agg cca  aag tgt aac agt tat  tgt ttt aaa        5049
Ala Thr  His Thr Ser Arg Pro  Lys Cys Asn Ser Tyr  Cys Phe Lys            
    1670                 1675                 1680                        

ata tct  gtg gat tgc tta tgg  aga gag tcc act gag  gtc ttt gca        5094
Ile Ser  Val Asp Cys Leu Trp  Arg Glu Ser Thr Glu  Val Phe Ala            
    1685                 1690                 1695                        

aga gac  agc ccc atc aca gtt  agt gac tct act gag  tcc aat gaa        5139
Arg Asp  Ser Pro Ile Thr Val  Ser Asp Ser Thr Glu  Ser Asn Glu            
    1700                 1705                 1710                        

gca aca  ccc tcc aag aaa cac  aac tct tgt tat gag  cgg gta tgc        5184
Ala Thr  Pro Ser Lys Lys His  Asn Ser Cys Tyr Glu  Arg Val Cys            
    1715                 1720                 1725                        

tcg gcc  cta gaa gcc agg ggc  cac agc tat gcc cct  gat aac tga        5229
Ser Ala  Leu Glu Ala Arg Gly  His Ser Tyr Ala Pro  Asp Asn                
    1730                 1735                 1740                        

caaaatgttt tccagctaag cagaaatatg tgatccacgt acagaaggga aaaaaatgtg     5289

ccccaaatga taaactattc atttattaaa aggcaggagc gatgctggaa ttccagtgtt     5349

ttattaagat gttcatgaaa tggacaaata ggttagtctt gggtgtggtc tttttgtcaa     5409

agtgtatcca gaatgtcaga atttctagta gtaatattta aatggttact tcatctgaaa     5469

ggcagaggct aaaagttttt aaattagctg tgtggtgagg cagcataata catcccactg     5529

gttaagatga gagaggctag agttatatac agatcatttg gatgggaatt agttctacaa     5589

aaatcagctg aaatcatgaa gacaaagagc tgcttgactt caaatgattg tgtgataagt     5649

aaacacagcc ttaatctctc tttacatttt acagtcctga caactgtgta cacctagtct     5709

gcagtgaacg gtctaaaggt gcaaaatatg taacaaaaat acccaagtgt attcccagtt     5769

tcccgagaga tatgacctga aacatgagac tgtggactgg actgggacaa gaactaacta     5829

ccactatcat agggctactg aacatggaga gtcagtcttt attaaaagac agttgcaaca     5889

attgcatgcg agggtttctg tataacagaa tatatgattt ttaaactatt tcctgggttg     5949

caaaagaaca catttagtaa gaaacaacaa tcttttcgca tctttttgaa atgcatattt     6009

gtgctgggtg taaagaagat tacaggaagg gcattacaaa tctggtcaaa acacctgtcc     6069

atttccatca ttgtactaac agaagtctgt actatttggt cagtttgtat ggaagcataa     6129

atattcccta aattcctgca gttagtcttc atagaaagca agctttctca acatgccatc     6189

tctgagatac tgatgacgtt tgccttactc acattccttc tctttcctgt gtaaaatgca     6249

gatagatgac caaatactct gggataaact gaatatgcct gtctttgtgc taaaatattc     6309

cataaatctt aagggtgtcc aaaagttctt tattgtcctt gtttgtaatc actttcttac     6369

ttctacacac catctgtatg cttctttatc tgttactctt cctgattgag gactcttctg     6429

agccttttat agtcctatcc atttcaaagc agaagctgtg gaatggtatt aaatattttt     6489

taaaattaat tcacctgttt aaaagaaaac attgcatctc aaaaggtgaa gatgattgtt     6549

ctttcttcca tatcctcctt acggcatgtc cttggataac ttttcaaaag gtatccacac     6609

ttttggttga gtttagtttt cttagaaagt agagaagtaa cactttacta gaataatgaa     6669

caaggaattg atttgctcta ggcccagctc tgccataaac tcattgtgta ttcctagaca     6729

ggtctttaac ttcatcagtg tgttgttttt gtgaagtgca aaataaagat agtgatagtt     6789

tctgctgtag ccctcatagg gacattggga agcagtataa gaaaaacttc agcaacatca     6849

tgattattga tgctaatagg aaaaataaat tcatgtaacc catagagaat ccaggtcaat     6909

tgtatttcct cttggaaagc agtttaacat gtaagcgttc aaagatgtga ttcagataaa     6969

aatacccagg tccatagtga aagatgtttt tcagtatgtt acttatggtt tagctactag     7029

ccagggaggt ggtagcccag agaaggcaaa ccacatacag atcacctgga gttgattata     7089

tgagtctatg cttttgagct ctttaggcaa cacattctca ttcctgtcat tatcagttga     7149

acctccatgc cacacatttc taagaattaa atgcctagat ggattaaatg tagtatgtga     7209

atgttctatg taaaagccaa tagagtatac aagtgacttg aatgattttt cctaacttgt     7269

ttgcaactga tagctcatat tgaatgtttt tatgtaaact ttgtatcgtt gggaagaatt     7329

acccaatcag agatttatat tttcataaat gttacattta gttaaatttt gttacagagt     7389

tgttacacta gaaaattatt tcagtcttca aacaatatac agtcttgtgt atgtattatt     7449

tgtatgaata aaagataaac tacttaga                                        7477


<210>  832
<211>  1742
<212>  PRT
<213>  Homo sapiens

<400>  832

Met Trp Pro Ala Gly Ala Gly Thr Lys Leu Pro Cys Pro Arg Asp Ser 
1               5                   10                  15      


Ala Leu Arg Arg Ala Ala Phe Ser Gly Asn Leu Thr Ala Leu Pro Ser 
            20                  25                  30          


His Leu Val Pro Ala Gly Arg Ser Val Arg Val Phe Ile Ser Ala Asn 
        35                  40                  45              


Pro Glu Asp Thr Gly Ala Glu Arg Gln Ala Leu Arg Glu Asn Val Tyr 
    50                  55                  60                  


Pro Lys Leu Arg Glu Phe Cys Arg Glu Asn Tyr Gly Leu Glu Phe Gln 
65                  70                  75                  80  


Val Ile Asp Leu Tyr Trp Gly Val Glu Glu Asp Glu Trp Asp Ser Pro 
                85                  90                  95      


Glu Leu Gln Lys Thr Arg Met Lys Leu Leu Glu Asn Cys Leu Lys Thr 
            100                 105                 110         


Ser Ala Gly Pro Cys Phe Val Gly Leu Leu Gly Glu Lys Tyr Gly Asn 
        115                 120                 125             


Ile Arg Ile Pro Gly Glu Val Glu Ala Ser Glu Phe Glu Met Ile Leu 
    130                 135                 140                 


Asp Ala Ala Ile Glu Ala Lys Leu Glu Thr Lys Leu Leu Glu Glu Trp 
145                 150                 155                 160 


Tyr Cys Arg Asp Glu Asn Ser Val Pro Ala Ala Tyr Tyr Leu Arg Pro 
                165                 170                 175     


Lys Ser Glu Met Leu Arg Ser Asn Arg Asn Ala Met Gln Pro Ser Thr 
            180                 185                 190         


Asn Ala Glu Asn Glu Lys Thr Trp Gln Glu Ile Ser Asp Glu Ile Lys 
        195                 200                 205             


Lys Ile Phe Lys Ala Ala Val Lys Leu Leu His Glu Lys Gly Lys Met 
    210                 215                 220                 


Lys His Ser Gln Ala Lys Arg Tyr Leu Phe Ser Ala Ile Glu Asp Glu 
225                 230                 235                 240 


Phe Asp Phe Ala Leu Gly Lys Gln Thr Pro Ala Phe Leu Lys Lys Cys 
                245                 250                 255     


Val Cys Tyr Ile Arg Lys Ile Ala Asn Ile Glu Arg Phe Val Lys Ile 
            260                 265                 270         


Pro Glu Met Gly Lys Tyr Met Asp Ile Thr Gly Thr Glu Pro Arg Ile 
        275                 280                 285             


Ile Arg Asp Pro Glu Ala Gln Glu Lys Leu Ile Lys Leu Arg Asp Glu 
    290                 295                 300                 


Phe Ile Pro Thr Ile Val Ala Ser Ser Asn Leu Arg Val Tyr Thr Ser 
305                 310                 315                 320 


Val Thr His Cys Asp Met Lys Leu Gly Tyr Ser Gln Glu Ile Glu Asn 
                325                 330                 335     


His Tyr Ile Glu Gly Leu Gly Lys Gln Phe Tyr Glu Asp Met Ile Asp 
            340                 345                 350         


Ile Ile Gln Ala Thr Ile Gln Gln Asn Phe Asp Thr Glu Thr Asp Thr 
        355                 360                 365             


Leu Tyr Asp Glu Ile Leu Gln His Ser Ser Leu Cys Lys Thr Tyr Ala 
    370                 375                 380                 


Ser Phe Tyr Glu Tyr Lys Cys Glu Ser Leu Asn Ile Val His Asn Tyr 
385                 390                 395                 400 


Ile Leu Pro Ser Lys Ala Gly His Ile Asn Pro Leu Ile Ile Tyr Gly 
                405                 410                 415     


Gly Pro Cys Thr Gly Lys Thr Leu Leu Leu Ala Glu Val Ala Lys Lys 
            420                 425                 430         


Ala Tyr Gly Trp Leu His Glu Asp Thr Gly Pro Glu Ser Asp Pro Val 
        435                 440                 445             


Val Ile Val Arg Phe Leu Gly Thr Thr Asp Met Ser Ser Asp Leu Arg 
    450                 455                 460                 


Thr Leu Leu Leu Ser Val Cys Glu Gln Leu Ala Val Asn Tyr Arg Cys 
465                 470                 475                 480 


Leu Val Gln Ser Tyr Pro Lys Lys Ile His Asp Leu Cys Asp Leu Phe 
                485                 490                 495     


Ile Asn Leu Leu Asn Glu Ser Ser Leu Gln Arg Pro Leu Val Ile Ile 
            500                 505                 510         


Phe Asp Ala Leu Glu Gln Leu Ser Glu Asn Asp Asp Ala Arg Lys Leu 
        515                 520                 525             


Trp Trp Leu Pro Ala His Leu Pro Arg Phe Val Arg Ile Val Leu Ser 
    530                 535                 540                 


Thr Leu Pro Asn Lys His Gly Ile Leu Gln Lys Leu Arg Cys Leu Ile 
545                 550                 555                 560 


His Glu Glu Asp Asn Tyr Ile Glu Leu Ile Pro Arg Asp Arg Lys Met 
                565                 570                 575     


Cys Ser Gln Val Leu Lys His Gln Leu Leu Arg Val Lys Arg Lys Val 
            580                 585                 590         


Thr Ser Gly Gln Gln Ile Tyr Val Asn Asn Ala Leu Ser Lys Cys Thr 
        595                 600                 605             


Leu Pro Met Phe Val Asn Leu Thr Phe Arg Glu Val Arg His Trp Arg 
    610                 615                 620                 


Ser His Lys Asp Val Asp Glu Ser Ser Leu Ser Val Thr Val His Glu 
625                 630                 635                 640 


Ser Ile Glu Gln Leu Phe Trp Ser Leu Glu Lys Lys Cys Gly Gln Lys 
                645                 650                 655     


Leu Val Ser Arg Ala Leu Gly Tyr Ile Thr Met Ala Lys Met Gly Leu 
            660                 665                 670         


Ser Glu Met Glu Leu Glu Asp Val Leu Ala Leu Asp Asn Ser Val Met 
        675                 680                 685             


Ser Glu Leu Lys Glu Asn Thr Arg Pro Ser Asn Pro Leu Arg Val Pro 
    690                 695                 700                 


Tyr Leu Tyr Ile Ala Arg Leu Lys Glu Gly Leu Ser Gly Tyr Leu Ile 
705                 710                 715                 720 


Glu Arg His Val Lys Asn Val Thr Leu Leu Val Trp Ala Asn Arg His 
                725                 730                 735     


Leu Gln Leu Ile Ala Gln Lys Leu Tyr Leu Gln Asp Asp Asn Asp Leu 
            740                 745                 750         


Arg Glu Met His Thr Ile Leu Ala Asp Tyr Phe Leu Gly Val Trp Ser 
        755                 760                 765             


Gly Gly Arg Arg Lys Ala Phe Cys Leu Glu Asp Pro Tyr Leu Asn Gly 
    770                 775                 780                 


Cys Leu Asp Leu Glu Asn Arg Ser Leu Leu Glu Glu Glu Lys His Phe 
785                 790                 795                 800 


Met Glu Gln Ala Ser Phe Asp Arg Gln Ala Pro Asp Gln Pro Trp Val 
                805                 810                 815     


Phe Gln Cys Asn Pro Leu Glu Pro Asp Ile Phe Phe Val Asn His Arg 
            820                 825                 830         


Lys Met Ser Glu Leu Leu Tyr His Leu Thr Arg Cys Gly Lys Thr Asp 
        835                 840                 845             


Asp Leu Leu Tyr Gly Ile Ile Met Asn Phe Ser Trp Leu Tyr Thr Met 
    850                 855                 860                 


Ile Lys Ile Gly Gln Phe Asp Lys Val Leu Ser Asp Ile Glu Leu Ala 
865                 870                 875                 880 


Tyr Asn Tyr Ser Gln Glu Lys Glu Leu Lys Phe Leu Ala Asn Thr Leu 
                885                 890                 895     


Arg Ser Ile Lys Asn Lys Val Thr Ala Phe Pro Gly Ser Leu Ser Ala 
            900                 905                 910         


Glu Leu Gln Gln Arg Leu Leu Pro Val Val Ser Ser Leu Pro Lys Leu 
        915                 920                 925             


Arg His Leu Leu Leu Glu Cys Asp Lys Asp Gly Pro Lys Tyr Cys Ser 
    930                 935                 940                 


Ile Val Pro Leu His Ser Ser Met Asp Val Thr Tyr Ser Pro Glu Arg 
945                 950                 955                 960 


Leu Pro Leu Ser Ser Ser His Leu His Val Thr Glu Ile Leu Pro Thr 
                965                 970                 975     


Cys Asn Pro Ser Thr Val Leu Thr Ala Leu Glu Asn Gly Ser Ile Ser 
            980                 985                 990         


Thr Trp Asp Val Glu Thr Arg Gln  Leu Leu Arg Gln Ile  Thr Thr Ala 
        995                 1000                 1005             


Gln Ser  Val Ile Leu Gly Met  Lys Leu Thr Ser Asp  Glu Lys Tyr 
    1010                 1015                 1020             


Leu Val  Val Ala Thr Thr Asn  Asn Thr Leu Leu Ile  Tyr Asp Asn 
    1025                 1030                 1035             


Val Asn  Ser Cys Leu Leu Ser  Glu Val Glu Ile Lys  Gly Thr Lys 
    1040                 1045                 1050             


His Gly  Ser Ser Ala Thr Tyr  Ile Asn Gly Phe Thr  Leu Ser Ala 
    1055                 1060                 1065             


Asn His  Ala Leu Ala Trp Leu  Glu Ala Ser Lys Asp  Val Thr Val 
    1070                 1075                 1080             


Ile Asp  Leu Leu Tyr Gly Trp  Pro Leu Tyr Gln Phe  His Cys Trp 
    1085                 1090                 1095             


Tyr Glu  Val Thr Cys Val Gln  Cys Ser Leu Asp Gly  Leu Tyr Ala 
    1100                 1105                 1110             


Phe Cys  Gly Gln Tyr Leu Asn  Thr Thr Thr Ile Phe  His Leu Gly 
    1115                 1120                 1125             


Ser Gly  Glu Lys Leu Cys Thr  Val Thr Ser Glu Phe  Ser Gly Gly 
    1130                 1135                 1140             


Phe Val  Lys Phe Leu Leu Ile  Leu Asp Thr Ala Gln  Glu Met Val 
    1145                 1150                 1155             


Met Val  Asp Ser Glu Gly Ser  Leu Ser Val Trp Asn  Thr Glu Asp 
    1160                 1165                 1170             


Ile Ser  Ser Pro Gln Leu Thr  Asp Asp Phe Asp Cys  Arg Arg Glu 
    1175                 1180                 1185             


Asp Ser  Glu Val Val Ser Ile  Glu Leu Ser Glu Asp  Gln Ser Ala 
    1190                 1195                 1200             


Val Leu  Ile Cys Lys Ala Leu  Ser Ile Glu Leu Leu  Asp Thr Gly 
    1205                 1210                 1215             


Leu Trp  Lys Val Ala Glu Lys  Phe Arg Ala Lys His  Asn Glu Arg 
    1220                 1225                 1230             


Phe Ile  Ser Ala Val Leu Ser  Lys Asn Gly Asp Cys  Ile Ile Ala 
    1235                 1240                 1245             


Thr Met  Glu Asn Thr Ser Ala  Val Phe Phe Trp Arg  Arg Asp Thr 
    1250                 1255                 1260             


Gly Gln  Cys Met Ala Ser Leu  Gln Glu Ile Ser Gly  Ser Ile Val 
    1265                 1270                 1275             


Lys Leu  Val Lys Ser Ser His  His Asn Met Leu Leu  Ser Leu Ser 
    1280                 1285                 1290             


Thr Ser  Gly Val Leu Ser Ile  Trp Asp Ile Asp Ile  Ile Thr Ala 
    1295                 1300                 1305             


Met Ser  Asn Ile Asp Lys Thr  Gly Lys Pro Ile Gln  Ser Leu Leu 
    1310                 1315                 1320             


Leu Pro  Ala Arg Gly Glu Ile  Ile Tyr Ser Leu Asp  Gly Ser Asp 
    1325                 1330                 1335             


Cys Val  His Lys Trp Asn Phe  Ser Ser Gly Phe Ile  Glu Ala Val 
    1340                 1345                 1350             


Phe Lys  His Glu Gly Ile Val  Glu His Cys Val Leu  Thr Ser Thr 
    1355                 1360                 1365             


Gly Asp  Ile Met Val Thr Ser  Asp Asp Lys Ser Ser  Gln Tyr Val 
    1370                 1375                 1380             


Trp His  Thr Ser Ser Gly Glu  Asn Leu Phe Arg Ile  Asn Gly Gln 
    1385                 1390                 1395             


Arg Ile  Ser Gln Leu Leu Ile  Thr His Asn Asp Gln  Phe Val Val 
    1400                 1405                 1410             


Ser Leu  Cys Glu Glu Asn Ala  Ser Arg Val Trp Arg  Leu Ala Thr 
    1415                 1420                 1425             


Gly His  Arg Val Cys Asn Ile  Leu Thr Thr Leu Gln  Asn Ala Phe 
    1430                 1435                 1440             


Ile Thr  Ser Ala Asn Thr Phe  Val Val Gly Met Thr  Lys Ser Lys 
    1445                 1450                 1455             


Val Leu  Ala Val Ser Leu Trp  Thr Gly Ser Ile Thr  Lys Lys Phe 
    1460                 1465                 1470             


Cys Cys  Glu Asp Gly Thr Thr  Ile Val Asn Phe Lys  Leu Ile Pro 
    1475                 1480                 1485             


Asp Cys  Pro Asp Ile Ile Val  Phe Ile Thr Ser Ala  Glu Thr Val 
    1490                 1495                 1500             


Asn Ile  Trp Ser Leu Thr Asp  Glu Val Ile Cys Arg  Arg Val Gln 
    1505                 1510                 1515             


Leu Pro  Asn Asn Phe Leu Lys  Asn Leu Glu Asp Phe  Glu Ile Ser 
    1520                 1525                 1530             


Pro Asn  Gly Lys Leu Gly Ile  Ile Ala Arg Gly Asp  Glu Asn Ile 
    1535                 1540                 1545             


Asn Val  Leu Asp Leu Tyr Ser  Gly Lys Leu Arg Val  Val His Ala 
    1550                 1555                 1560             


Ser Gly  Ile Ile Trp Arg Gln  Arg Leu Ser Arg Asp  Gly Arg Tyr 
    1565                 1570                 1575             


Leu Val  Tyr Ile Cys Phe Arg  Asn Gly Glu Glu Glu  Asp Glu Asn 
    1580                 1585                 1590             


Gly Ala  Ile Phe Ser Leu Ile  Val Met Arg Leu Ala  Asp Gly Lys 
    1595                 1600                 1605             


Asn Ile  Gly Ala Cys Ser Leu  Tyr Lys Thr Pro Thr  Phe Leu Ala 
    1610                 1615                 1620             


Leu Ser  Gln Arg His Leu Asn  Ile Ile Val Gly Phe  Asp Asp Gly 
    1625                 1630                 1635             


Ser Ile  Gly Ile Tyr Thr Val  Val Asp Arg Val Asp  Ala Ala Leu 
    1640                 1645                 1650             


Lys Ile  Lys Ile Ala Thr Ser  Asn Ser Arg Gln Ile  Phe Asn Asn 
    1655                 1660                 1665             


Ala Thr  His Thr Ser Arg Pro  Lys Cys Asn Ser Tyr  Cys Phe Lys 
    1670                 1675                 1680             


Ile Ser  Val Asp Cys Leu Trp  Arg Glu Ser Thr Glu  Val Phe Ala 
    1685                 1690                 1695             


Arg Asp  Ser Pro Ile Thr Val  Ser Asp Ser Thr Glu  Ser Asn Glu 
    1700                 1705                 1710             


Ala Thr  Pro Ser Lys Lys His  Asn Ser Cys Tyr Glu  Arg Val Cys 
    1715                 1720                 1725             


Ser Ala  Leu Glu Ala Arg Gly  His Ser Tyr Ala Pro  Asp Asn 
    1730                 1735                 1740         


<210>  833
<211>  1184
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (37)..(840)

<400>  833
gggcgcttct tccgggtggg gccccgggcc gaggcg atg gcg ccc tgg gcg ctc         54
                                        Met Ala Pro Trp Ala Leu           
                                        1               5                 

ctc agc cct ggg gtc ctg gtg cgg acc ggg cac acc gtg ctg acc tgg        102
Leu Ser Pro Gly Val Leu Val Arg Thr Gly His Thr Val Leu Thr Trp           
            10                  15                  20                    

gga atc acg ctg gtg ctc ttc ctg cac gat acc gag ctg cgg caa tgg        150
Gly Ile Thr Leu Val Leu Phe Leu His Asp Thr Glu Leu Arg Gln Trp           
        25                  30                  35                        

gag gag cag ggg gag ctg ctc ctg ccc ctc acc ttc ctg ctc ctg gtg        198
Glu Glu Gln Gly Glu Leu Leu Leu Pro Leu Thr Phe Leu Leu Leu Val           
    40                  45                  50                            

ctg ggc tcc ctg ctg ctc tac ctc gct gtg tca ctc atg gac cct ggc        246
Leu Gly Ser Leu Leu Leu Tyr Leu Ala Val Ser Leu Met Asp Pro Gly           
55                  60                  65                  70            

tac gtg aat gtg cag ccc cag cct cag gag gag ctc aaa gag gag cag        294
Tyr Val Asn Val Gln Pro Gln Pro Gln Glu Glu Leu Lys Glu Glu Gln           
                75                  80                  85                

aca gcc atg gtt cct cca gcc atc cct ctt cgg cgc tgc aga tac tgc        342
Thr Ala Met Val Pro Pro Ala Ile Pro Leu Arg Arg Cys Arg Tyr Cys           
            90                  95                  100                   

ctg gtg ctg cag ccc ctg agg gct cgg cac tgc cgt gag tgc cgc cgt        390
Leu Val Leu Gln Pro Leu Arg Ala Arg His Cys Arg Glu Cys Arg Arg           
        105                 110                 115                       

tgc gtc cgc cgc tac gac cac cac tgc ccc tgg atg gag aac tgt gtg        438
Cys Val Arg Arg Tyr Asp His His Cys Pro Trp Met Glu Asn Cys Val           
    120                 125                 130                           

gga gag cgc aac cac cca ctc ttt gtg gtc tac ctg gcg ctg cag ctg        486
Gly Glu Arg Asn His Pro Leu Phe Val Val Tyr Leu Ala Leu Gln Leu           
135                 140                 145                 150           

gtg gtg ctt ctg tgg ggc ctg tac ctg gca tgg tca ggc ctc cgg ttc        534
Val Val Leu Leu Trp Gly Leu Tyr Leu Ala Trp Ser Gly Leu Arg Phe           
                155                 160                 165               

ttc cag ccc tgg ggt ctg tgg ttg cgg tcc agc ggg ctc ctg ttc gcc        582
Phe Gln Pro Trp Gly Leu Trp Leu Arg Ser Ser Gly Leu Leu Phe Ala           
            170                 175                 180                   

acc ttc ctg ctg ctg tcc ctc ttc tcg ttg gtg gcc agc ctg ctc ctc        630
Thr Phe Leu Leu Leu Ser Leu Phe Ser Leu Val Ala Ser Leu Leu Leu           
        185                 190                 195                       

gtc tcg cac ctc tac ctg gtg gcc agc aac acc acc acc tgg gaa ttc        678
Val Ser His Leu Tyr Leu Val Ala Ser Asn Thr Thr Thr Trp Glu Phe           
    200                 205                 210                           

atc tcc tca cac cgc atc gcc tat ctc cgc cag cgc ccc agc aac ccc        726
Ile Ser Ser His Arg Ile Ala Tyr Leu Arg Gln Arg Pro Ser Asn Pro           
215                 220                 225                 230           

ttc gac cga ggc ctg acc cgc aac ctg gcc cac ttc ttc tgt gga tgg        774
Phe Asp Arg Gly Leu Thr Arg Asn Leu Ala His Phe Phe Cys Gly Trp           
                235                 240                 245               

ccc tca ggg tcc tgg gag acc ctc tgg gct gag gag gag gaa gag ggc        822
Pro Ser Gly Ser Trp Glu Thr Leu Trp Ala Glu Glu Glu Glu Glu Gly           
            250                 255                 260                   

agc agc cca gct gtt tag ggttgctgga ggccgggcta ccgtcttgtg               870
Ser Ser Pro Ala Val                                                       
        265                                                               

cctgaaaacc acggggcctg tccccagctg gggtgagcgc tcagagggcc tggggccctc      930

actcctgccc acgcctccca gaccccagaa cggagcttca agtcagacag atccctgcct      990

tggtgggcag ttctgccttc caaggaagaa ggggaagaaa aggacctgtg ggtggctcag     1050

gcccaagcag accccgggct ccaccccagc cccgcccagg ctgctgccag tgcacacttt     1110

tacaaattta atataaagca agtccagtct taaaaagaca aaaaaaaaaa aaaaaaaaaa     1170

aaaaaaaaaa aaaa                                                       1184


<210>  834
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  834

Met Ala Pro Trp Ala Leu Leu Ser Pro Gly Val Leu Val Arg Thr Gly 
1               5                   10                  15      


His Thr Val Leu Thr Trp Gly Ile Thr Leu Val Leu Phe Leu His Asp 
            20                  25                  30          


Thr Glu Leu Arg Gln Trp Glu Glu Gln Gly Glu Leu Leu Leu Pro Leu 
        35                  40                  45              


Thr Phe Leu Leu Leu Val Leu Gly Ser Leu Leu Leu Tyr Leu Ala Val 
    50                  55                  60                  


Ser Leu Met Asp Pro Gly Tyr Val Asn Val Gln Pro Gln Pro Gln Glu 
65                  70                  75                  80  


Glu Leu Lys Glu Glu Gln Thr Ala Met Val Pro Pro Ala Ile Pro Leu 
                85                  90                  95      


Arg Arg Cys Arg Tyr Cys Leu Val Leu Gln Pro Leu Arg Ala Arg His 
            100                 105                 110         


Cys Arg Glu Cys Arg Arg Cys Val Arg Arg Tyr Asp His His Cys Pro 
        115                 120                 125             


Trp Met Glu Asn Cys Val Gly Glu Arg Asn His Pro Leu Phe Val Val 
    130                 135                 140                 


Tyr Leu Ala Leu Gln Leu Val Val Leu Leu Trp Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Trp Ser Gly Leu Arg Phe Phe Gln Pro Trp Gly Leu Trp Leu Arg Ser 
                165                 170                 175     


Ser Gly Leu Leu Phe Ala Thr Phe Leu Leu Leu Ser Leu Phe Ser Leu 
            180                 185                 190         


Val Ala Ser Leu Leu Leu Val Ser His Leu Tyr Leu Val Ala Ser Asn 
        195                 200                 205             


Thr Thr Thr Trp Glu Phe Ile Ser Ser His Arg Ile Ala Tyr Leu Arg 
    210                 215                 220                 


Gln Arg Pro Ser Asn Pro Phe Asp Arg Gly Leu Thr Arg Asn Leu Ala 
225                 230                 235                 240 


His Phe Phe Cys Gly Trp Pro Ser Gly Ser Trp Glu Thr Leu Trp Ala 
                245                 250                 255     


Glu Glu Glu Glu Glu Gly Ser Ser Pro Ala Val 
            260                 265         


<210>  835
<211>  2033
<212>  DNA
<213>  Homo sapiens

<400>  835
aaatagaaga ttgtggatcc ctgggaacgc agagcaggaa tgcgtggcag gaaggaatct       60

cccagggatt cacagttcac ccctaaatca atccgtgggg cccgaggggc aaagtatctg      120

agtgacccag ccctcagtct tgtgtccgtt cctgagaagg agctcagcct tgcccctcag      180

gagctgcatg taccaaatac cacagatgga ggcgtgacac agactgtcca ctgcagagac      240

catggacgga ggcagcctcc gagccagccc agcagccatg gacggaggag ccttggagcc      300

agcccagcag ctctcctcac tggaggggtg gacgggacag gaccggctgc tcattccacg      360

ctggagggag gccaggagtc tcagctggat gcagtcacct gacctggaga gttcaaagtg      420

cctaacacag ggatgctgct acccacaagc ctggatcctg gcgtgctccg cggctctcct      480

tcaagccctg gcctcatcag acctccaagg ctccctagac agggttaatt attcacgtgg      540

cctgggaccc agggttcgtt tgtttgtttt tcccgacaca gtagggtcca cgaggaagtc      600

aggatccacc ggcaatattt gcagtgttat gttgaatgtg gcaactggct gcgtgaggat      660

agagaagtaa acagcatgtc cggtggcagt cggttaccac acagaattta ggaggcccag      720

tgaaatgcaa atgctaggta agtgacacgt aagtttttga tataagcata tcccaggcaa      780

catttattta ttggaaattg aaactcacat ttaaccggcc atattatttt ttttaaattt      840

ttttgttctc taaatctatc ttttgtttgc cgaatttcta gcaaccttag atggagaggt      900

ggctctgaga ttagcatccc cacaggccca cctctggctg gagagacaaa gggaggtggg      960

gtgctgccgg ggagggagag ccaaggtcta cttccacgcc gctcccagac ctggggccag     1020

aggcccgctt gctgggggct ggggctcaga ggggagcgag cggctgctgt caggctgtct     1080

gaaaatgctg tgcggattcc ccgattttct ctcgcctggc aggtcacctg gcccacactc     1140

tcctcccctg atcccctgag tgctcccctc cccctgcagg tccccctccc ctctgggtga     1200

gcctggatgc cagcaccctg ttccgcccgc ccagcatgca gaacaaaagc acaacgcaca     1260

gaaacacagc cggtgcgcgc agggcggcag gctggcttct ccctccctcc tgccgaggtc     1320

tccggcccct tcccccttcc ctccttccct cccctctcct cttctattag aaaatgggag     1380

tgttagggtt gaattgtgtc cccccaaaac aggtatgttg gggtcctgat tcccagtccc     1440

ctagaatgtg accgtgcttg gagataagac ctttacagag taactgatta aaatgaggtc     1500

attagcaggg accctagtgc agcatgactg gtgtcctttc aaaaaggaga aatttggata     1560

cagacataga cacacactga gggaaggtga agtaaagggg caaggagaag acggcctgca     1620

acgggagtga cgcccttaca agccgaggga cgcctggcag tgccagctga caccaggagc     1680

agggagaggc caggaagcct ggcagtgcca gctgacacca ggagcaggga gaggcctgga     1740

acggttctcc ctggagacat ccgggacaca ccttgatttc aggattccat gatagcttcc     1800

agaactgcca aagaacgcat ttctgtgttt tcagccaccc agtctgtggt atcttgtgac     1860

tgccgcccta ggaaagtaaa acaaggagtt aattcatgaa gggtggggga aatacgtacc     1920

ctttgaaata ccacctagag gaaggggtaa tagtacaccc gatcatgtgc tccagtttat     1980

gaaatagttg cacgtcactc ggaattttga aaaacaatat attttcagga ctc            2033


<210>  836
<211>  1741
<212>  DNA
<213>  Homo sapiens

<400>  836
gagtgcacct ggcctgagag cccgccaggc cctgcccctg ctcggctcct cgtctgctga       60

agctcgggac ctctagccag tggccctctg cagccacggg gaatggggct gagagccggt      120

tcccgctgca gggcagacca cctagctcag ccgcagccac agggacatct ggccccggtt      180

ctgagatgtg gggagtgctg gcgggctcgg gggttgcctg gaggctgctg cctgcacaca      240

gaaggcggat gcagcttggg tgcccaggcg ggctggagga cagcgggctg ggaagccagg      300

ggccgccggg acctggggct ggaaaccaca tctgcccaca gccgcagcct cctgcacctg      360

tcatcctggc ggcgccctga cgtcggagaa gcagcaggcg cggagctcct gcagcgggca      420

ccgctgcagc aacccgaccc ggcgcaggcg gcagtggaag gcggcctgct agcacggctc      480

ccgcggcccc aggaccaggg gtgcggccag caccgccctc actccccgcg tctcgtggat      540

attgccctcc ctggaggcgg ctggacctaa gcgaggctcg cagcgatcgg ccccgcgaag      600

actcgcatgc agggctcagg atcccgcatt ctggcgccgc ggcaccgcac ctttcagcag      660

ccctgctcct cttcttgttg gtaaactttt gtcactctgc catgaaaagc atccaggcgt      720

ccttgatttc gacattgcgt gcacgctcag ccgagctcat cagacgggcg gttgtcccca      780

gagcccgcgg gtagcttgtt cccgggcggc ggctcctgct ggatgcagct ccttgtgggc      840

ctaccaggct tggtggagcc acagcagacc tgtggagagg aagagtaagg cgggctctgc      900

agggcagtgg gccgggacca tgagagaggc gggtcagtct gggctccaag ctcagcctct      960

cggattcccc gggacccacg gcttataatg cgcttaaatc ccacgcctcg cccgagagac     1020

agcacgtcac cgtcaccgtc accgcctagc gcccctgacc cgctcccact ccgctgcagc     1080

ggagggtgtg tgagggagag ggacgcaggg agggaaaagc gttgggaggg caaacatctt     1140

ttcataagct tttccccttc tatatgccat ctctgatggg agcctcttta gatctttcgt     1200

ccatttacta attgggttgt tcgatttctt attgttgagt tgtaagtggt ttttaatggt     1260

ctggatgcca gacaggtgtt ttgcaaatat tttctccgtc tgtggcttgt ttctccattc     1320

tcttatttcc tttcccagag caaaagtttt taattgtaac gacttcatac caatatcttc     1380

tttcatggta gaaatttgtc ttttatgtac tttactgttg tatctacaaa gtaattgcca     1440

aacccaaagt tacctaaata tcccttttgt tattttacag aagttttaca gcttttggat     1500

ttaaatttag gtctaaaaat tgaattcata aaagtagaga gtataatgat gcttaccaga     1560

ggctgtgttg ctggggagaa aaatgggaag ttgttcacag atgcaaagat tcagttaaac     1620

cggagaaatg cgttttgaaa tctattgcac agcaggatga ctatagtcaa taataatgta     1680

ctgtatattt aaataacaaa aagtaaattt caaatatcta accacaaaaa aaaaaaaaaa     1740

a                                                                     1741


<210>  837
<211>  1384
<212>  DNA
<213>  Homo sapiens

<400>  837
gtcggttgta gtggcctcgc cgcccggtcc gctgtcgcag cgctcatccg cgccgggagc       60

ccttggctgc gtcgcccggc agccgcgtaa agacgctgcg aattgacgcc ttttataata      120

aagacactta tcttgcccaa gagctgggct ggagtgtagt ggcgcaatct tggatcacca      180

caacctccgt ctcccaggtt caagcgattc tcccgcctca gcctcctgag tagcaattac      240

aggtaaaggt tgtggccaga aagcacgggc agcctgggac tcctgttgcc atagcaaccc      300

agctaccgcc gaggacttct gcggcttttc cagcccagca gcagccgctc cagcaaatac      360

atatggggac tccagtacct ggagatgtga attccataaa aatggaagca tctaagaggc      420

agtgaacact ggcgcccaca ggagaaccag gtgcatcagc gcattgcgga gctgaggaaa      480

gcaggtctgt ggtcccagag gcgtctgctg aagctgcagg aggcccacga cccaagtccc      540

actgggacta tctgctggag gagatgcagt ggatggccac agactttgcc caggagaggt      600

ggaaggtggc ctctgtgaag aagatggtca gagctgtggc ccggcagctg caggacagga      660

cgcgcaggga ggccggggcc aggagggagg agccgagcag gctgaggcag acgtcacctg      720

tactaccaga gaaatcgagc gtccctggtc tagtactgcg caggtaaaga ttccagcatc      780

ttggaagcaa gtgctccact ggaaaataaa agccacgtgg agcacttgat tagactccag      840

aaacagaaac tgcagctgct cccaccaccc ccaccaccac aggccctgcc cggggcacag      900

ccaaccacac aagtgcaagt gcagccatca cccgcctacc acagcagagc ccccagctca      960

ccacagtcac ggccccgaga cccagagccc tgttgatggg caccaccatg gccaacctcc     1020

agactcgagt ttccacctcc cacctgcaag gcccaagact gacgtcagcg ctgacgtacc     1080

agatggccca ggttgctgtg gccacgcccc ctgtggtgtc tgtcctggca gttgtggtgc     1140

tgtcagccag ggtcacagtg cttccatcaa cgcaacggga tcagtgttgt gataaggcag     1200

ctgcaaaaag cggcaggtag gcagccacct tcgcctcacc aaactcgaaa caactcactt     1260

gagtgagttg catcaaacct ttctaaattt ctcattctag aagttgctga gttgttctgc     1320

catgtgttaa cttttttttc ttatcagtaa aatcttttat ttggttaaaa aaaaaaaaaa     1380

aaaa                                                                  1384


<210>  838
<211>  1296
<212>  DNA
<213>  Homo sapiens

<400>  838
gtgaaagagc aggttctgct tctttggtgt agtcctgaag cttcctaaga aacttcacat       60

caggtgatgg ataggagcaa ccctgtaaaa ccagccttag actatttttc aaacaggctg      120

gtgaattacc agatctccgt caagtgcagt aaccagttca agttggaagt gtgtcttttg      180

aatgcagaaa acaaagtcgt ggacaaccag gctgggaccc agggccagct gaaggtgctg      240

ggtgccaacc tctggtggcc gtacctgatg cacgaacacc ccgcctacct gtactcgtgg      300

gaggatggtg attgctcaca ccaaagcctt ggacccctcc cagcctgtga cctttgtgac      360

caactccacc tacgcagcag acaagggggc tctgtatgtg gatgtgatcc gtgtgaacag      420

ctactactct tggtatcgca actacgggca cctggagttg attcagctgc agctggccgc      480

ccagtttgag aattggtgta agacatcaca atcccattat tcagagcgcg tatggagtgg      540

aaacgcttgt agggcttcac caggtaagcg gtgttgaact ttctgcttgt gtattctctc      600

tgggcagaga tgccacttgc ctcccccacc atgccatctc tgaagaatat tacagaccat      660

tttggagcat ggtgaataag aaattttcac cttaggagtt cagttgaata gtcattttta      720

tatttgtgac tgcaagtcac tcttaggggc tgtacttcct tagtactggt agcattatta      780

tccaatggac ttttatagct ttcattaggt tttcttttgt ttttgttctt taaagaacgt      840

tttacttatc ttagtatttc atttttcatc tatattatga ggcagtaaga gtcttctgtt      900

tttccaaagt tgagactgct ttatatttat ttcgtattgt ctacagctgt agtgttcaat      960

acattagcca ctagccacat gtggttattt aaataagata aaataaaaat tggccgggcg     1020

tggtggctca cgccggtaat cccagcactt tgggaggccg aggcgggcag atcattaggt     1080

caggagatcg agaccatcct tactaagacg gtgaaccccc atctctatta aaaatacaaa     1140

aaattagccg ggcgtggtgg cgggcgcctg cagtcccagc tactcaggag gctgaggcag     1200

gagaatggcg tgaacctggg aggcagagtt tgcagtgagc cgagatggcg ccactgcact     1260

ccagcctggg ggacagagcg agactccatc tcaaaa                               1296


<210>  839
<211>  700
<212>  DNA
<213>  Homo sapiens

<400>  839
ctcctgcttc agcctcctga gtagctggga ttacgggcac ctgccaccac acccagctaa       60

tttctgtatt tttacaaaaa tttggactct gcttagattg gcttagtttt ctctttagtc      120

aaatcttcag gaaccaattt attaccatta aaaatgatct aacaagcttt atttttatta      180

ttgttaaaaa tcctcatttt gaggaacaca accacaaagt aaagaatgtt ttcattgatt      240

taaccagtaa aaatcaatat ttaattataa aatttttttt ttcttcagct aaaacagcgg      300

aagaggtgat ttattatatg gttgttacac tcggccacaa ataaacacag aaatagtcca      360

gaatgtcaca ggtccagggc agaggaccaa catgggcatt ttgtttatga gcaaggtggg      420

tctcagaggt gatcggcgat cagagggcga tgaagttcta gatccattga gacaagctct      480

agacagtagc atgcagtccc acaacttgta ccagcatccc cagcatctgg cattccatgt      540

ttctgctcct gtggcctcca cagtgcaaca agctagcggt ttacttggac ctctacctca      600

tctttcttct tttgcgcttc agcctgcgca ttcgcttctt cctccacttg gctctcatgg      660

tgcaggtttc caagaaaatg gcgctaaggc cgagagttaa                            700


<210>  840
<211>  2440
<212>  DNA
<213>  Homo sapiens

<400>  840
atggcagtgc tggaggaaga attcacgttg tcttcagtag tcctgagcgc ggggcctgaa       60

ggactcctag gcatgaagca gagtgacaaa acagaccagt ttctagtgac agacagtggc      120

agaaccgtga tcctctataa ggtttctgat cagaaaccct tggggagctg gtcagtgaaa      180

cagggtcaaa ttgtaacatg tccagctgtg tgcaactttc aaactggaga gtatattgtt      240

gtacacaata ataagatttt aagaatctgg aataatgaag atgtaaacct ggataaagta      300

tttaaagcta cattgtcagt tgaagtatat aggaaacttt cagtgcaagg gtcagaaccc      360

ttggtgctct tcaaggaagg tgttcgtggt ttagaggcct cgcttgcagg cccccagcag      420

aaaattgaag ctgttatctc tgatgaagtg attaaatgga caaagttttt catagtattc      480

agacatcctg ttttaatttt tattactgaa aaacatggaa atcactttgc ttatgtgcaa      540

atgtttaact cacgtatctt aaccaaatat acactcttag ttggacaaga caaaaactat      600

tttatagaga gttttactgc attggtagat cagaaattca tctctttgac gtcattaagc      660

tctgatggtt gtatatatga aaccttgatg ccaatacgtc caactgaccc agaaaaaaat      720

cagagcttag ttagatcact gttgctcaag gctgttgtgt ctggtaacac ttgaaatgga      780

gttgcactca ctgcgctgga tcaggatcac gtcacagtcc taggaagtcc actagcagct      840

tctaaggaat gcctctctgt atggaacata aaatttcaaa cactacagac ttcaaaagag      900

ttaccacaag ggaccagtgg tcaactctgg tattatgggg aaaatgtgtt tatgctacgt      960

ggaaaatctc tgtgattcca tacaactgtg aagtgtcatc attagcaggt gctcatggaa     1020

aactcaagca tagtcaagat ccaggaactc atgtcgtgcc ccattttgta aactgggaaa     1080

cacctcaagg atgtggactt gggtcccaga actcagagca gtcaagaaga attttaagga     1140

gacgaaaaat tgaagtgagt ttacagccag aggtatcacc atccaaacaa cttttgtcaa     1200

ccataatgaa agattcagag aaacatactg aagtagaagt atggaaattt ttggctctga     1260

agcagacccc tgactttcat actgtcactg gggacacagt aacaggactt ctggaaaggt     1320

gtaaagcaga accatcattt tatccccgga actgtctgat gcaccttatc caaatgcatg     1380

tgctttctta cagtttgtgc cctgacttaa tggagattgc cttaaaaaag aaagatgtac     1440

agttgttaca actctgtcta cagcagttcc ctgacattcc tgaatcggtc acctgtgctt     1500

gcttacaaat tttcttgaga attggtgatg acagtattca agaaacagat gtcagtatgg     1560

agtcagtttt tgactatagt aattctgtac atgatgagaa aatggaagag caaactggaa     1620

ttcttcaaaa tggcttcaat cctgaagaag ataaatacag taactgtgat caagagttaa     1680

ataaaaagcc ccaggacaag acaaaggaga ccatttcatg ctctgtgata ccaaaaagag     1740

cagctctact taatgcaatt cttcattcag catatagcga aacatttctt ctgcctcatt     1800

tgaaaaacat cccagcacag catatcacac tgtttctcaa gtgtttgtgt ttcctttatc     1860

tgaagtgtag cgaaaatgct actatgactc ttcctggaat acacccacct accttgaacc     1920

agattatgga ttggatatgt ctacttctgg atgcaaattt tactgttgta gcaatgatgc     1980

cagaagcaaa gaggccactg ataaatcttt acaagcttgt aaaatctcag atatctgttt     2040

attccaagct caacaagatt gaagtaagtt tttgggagct acagaaatta aatcaagaaa     2100

agaataacag aggattatat tcaattgaag tgctggagct cttctgatat taccaattct     2160

ccttcatagt cattttataa agctctttta tgtaactctt gcttcatcca ggcaagagtg     2220

gtgttttgtt tgcgaccctc tcggtgtcaa gagaaacatg tcagtgagta cctggaccat     2280

cacttattga tgctccgggg tagaactgca ggtttcacat gaacctattc taggttgtgg     2340

acattggtgt gcagaggttc tgcaattttt taaaaatatg taactgggtt gattttaagt     2400

aaaattattt gtgtattgat aaaagtctaa tttcttatca                           2440


<210>  841
<211>  852
<212>  DNA
<213>  Homo sapiens

<400>  841
gaatttgctc tctgcctcac tgcctgagct ggaacatttg tcttctgtcc tcagactggg       60

ctttacccca tctactccca ggatactcag accttcagac tctggctgaa ttataacact      120

gactttcctg ggtctccagc ttgcaaatgg caggctatgg aacttctcag cccacaatca      180

cccttcaggg tagaccgagg agagcacctc cccttcctgg tgaagggagc ccgatacacg      240

ctggtgccgg ctggccaaga aggaggtgga caaacctggc gaccgctccc tggcaccacc      300

tcaccagagg acagctcaca cctccacagg ggtcagaaga aaggagctgc cctggggatg      360

gctgtgtatc cctacaactg ccaggcacat gccccttgaa cacccgatgc tacgtgtccc      420

aaaggaaact ggtctccacc cacccccggc ccgtcctcgt cctgggtacc ccaccttagt      480

aaatggcgcc accatctgcc cggtcactca gcgagaaact caactcctgg cagcagatga      540

cgggcactct ggttaaatga ctctctccag cctccaagtt caacctgcag ggaagccctg      600

gaaatcctgt ctccctctgc cctgcctctc cttcagctcc gaaccccacc ccactcagta      660

catggccccc caacaggctt tcaaatgtct gccttcccca aaccaatctg tggttttaaa      720

agaagtaagg tcaggtacag tagctcatgc ctgtaatccc agcactttgg gaggccgagg      780

caggcggatc acctgaggtc aggagtttga gaccagtctg gccaacatgg cgaaaccccg      840

tctctactaa aa                                                          852


<210>  842
<211>  3350
<212>  DNA
<213>  Homo sapiens

<400>  842
gtgccactgc tcaaggtctc catggctgag cctgggggct cttacaacag gctccatgcc       60

caaggtggca gttgtggaac catcagagag ggcacagagc tcatggttta tggtgtaggg      120

gctgggagct tggagggggt tgtgtggggg gctggactca ggcggccaga ggcctgggaa      180

catcatcctg ggcacgccgt acctgtcacg cagtctgagt catgctgcca gggcaggtat      240

ccagctccca gcctgggagt gccaagagcc aaatccacgg cagattaggg gtgatagtca      300

cggtcccacg tcctctatct gtcagcaatc cagtggtgat ctaggataaa agcctgagag      360

tcctatacac gcggtcatcc cacaacacac ttcataggcc atggaaggac acacagcccc      420

cttccctccc tcccaggtac catgatagct gctagcgtgc gactgaaggc agggtccctg      480

gcccctgctg aagcactact gctggccagc aggctcacgc accttggcct gttgcttcta      540

ggggttgcct gtgctattca gccaatagtg ctgctggccc agctgagcgc cgcctagaga      600

gctcacttcc ctttcctgcc acggagtctc cctcttctgc ttttcccagc aggaagggcc      660

cagcctcacc tatgtaacct gcagcccccc gccaaccagt taaggctccc ctcttagact      720

tagaagtcta tggccaatgg catccggcta cctgccctcc ctgccttccc cagggttcct      780

cagaggaccc tgggctttct gatggcccag aggggcctct ggcattcact ccagccagcc      840

atcccttata gctccaccat tttggttcaa tcagtgttcc ttctctatca ggtctggtgg      900

ctgttggatg gggctctcca agcaagaggt ggccctgggc cagtgcgttg gaagacatgg      960

ggaccacaga agagggaagc ccgagggagc tggcattggt ctgaactgtg ggtggatggg     1020

tggattgcct gggttccatg agacaggcca gcgtgtgtgg ggtagggagg gccgccgcag     1080

tccccaggca ctacctatga agctccagct tctccctcca tctccctccc ctttcccttc     1140

cagcccctct tttccaggaa ccttgccacg cccacaccta cgccctcccc tccccggccc     1200

tccacagctg ctgcagcgca cccatactct gcacttgcct caccagctct ggcttttctc     1260

taacccgttt tctctctgct ttctctccaa ctgccagctg atcgggtcag gcaagtccat     1320

cccgtcctga gagccccagg ccccacttcg acctctaaac acatccctcc tcttctcaga     1380

gacctccctt tccaagcctg cctgggcggg tgtcctgtga cttgacagtg gctcccccag     1440

ccccaaagcc agcccccttc ttctgtgact tagtctgttg tagtggtgag ctgacacgtc     1500

caggtgtgac cgttgctgaa aacttgtgcc ccctctgtgg tatgcccctg ccctgttcta     1560

taaatagcta taaattctct ctctcacaca cacacacaca cacacacaca cacacacata     1620

tatacatata tatacgtggc caactgcctc acctctagca ctgggaatca gtcccgtgct     1680

gtgcttgtgg aatcttgtag cccagcaaga ggaagctgtc tcctgacatc gcccctccaa     1740

agtgcaccac ctccagtgag cttccgggac atgcgcggcc tgtggacagc cagcccccgc     1800

catccctccc gcccttctgg ccaagcatgg cggtgctgtg caggcagctg tgtggcctga     1860

cagtctctac cagtcctgct gtcccttggc tgagaaaccc atttctggat gacagagaat     1920

gtgtcctctg ctggctgtgt tctctatgga gctcagggga tggaaaaggc caagccattt     1980

ttagggtgct gttgggagca gtgaaaaggt cacacccttt tcaagggaca cttttcctgg     2040

aaagtccctg gagcttagct ggctcttacc ctgtgaagcc agctctggcc actaggggac     2100

agggccctga actcagcctg gagggaacct gcggggcagc cggcactctg gagggacaga     2160

caggccaccc ggtgcagaca ggagagggag gcagggggac agaacggaag acacctgggg     2220

tggatggaag tcagtgccct tgggcactgg tatctgtctt ccctgccaca gctagatcag     2280

gcttctcaac cagttggctg tcagggccag agtgtactcc gtaggcgcca tggcagtccc     2340

catgaaatcc accaggtgtc accaggcagc atacaggtaa caggcctgga aggtccccaa     2400

cagcccagct ggacatgctg agacactctg gggctcctca ttcagtggga caaactgcag     2460

gacccagtga gggaaatggg aacataccag gccgagcagt atggctaaat ccatttattc     2520

caaaatcaaa agcaaaaaac aaaaaacaaa aaacaggagt cccatcacca ggcagccatg     2580

accccatccc cgcctgcttc ctcgctccta tgctagcaat aaataagttt cccagccgcg     2640

aataattata agaacctctt cctcatatgc cagctgcaac ctccgctagg tacgatacag     2700

aatgttacac agctacagta tgtacacggg ggaagggggg ccacccccag cagcctgtgc     2760

cctggcctgg tctacagtta actccactgt cccgcctcag ctgcctctct gagtaagaag     2820

atgggagccc ccctgaggga aaagttgctt tggtgagagt aagaaggccg tcagacctcc     2880

tccaaacaaa ccaactccac caacctctgg ctcttaaata acaaacatca tcatccagaa     2940

atgtaaggac tcagccttgg tcaaggtggt aaagggtctg tttgtctccc tccattagac     3000

aagggtcttg tcttgctacc ctaatggtaa agggctgact ggggaggggt tgtagggaca     3060

tggtgggggt gaagactcca gacccacttc tccaggctta tgctgacagg ggcctgcttt     3120

tatttatttt tatttttatc ccatgacttt ttttaaatcc tgtaactaat ttttcataac     3180

tttttaaaat aacttttcat aaaacttttt ttttactttt tttccacaac ttttttttgc     3240

cacttttcca cagtattttt ttatcctgta actttttcat cccacaactt taattcctgt     3300

taactttttt agtttgtgtt cttttaataa acacacttac atagttacaa                3350


<210>  843
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  843
gggccattag gaaacagcta                                                   20


<210>  844
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  844
agggtacata tctttttccc attctt                                            26


<210>  845
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  845
tggaaaggca aaggtcagtg catga                                             25


<210>  846
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  846
tgaggacgaa gacgaccct                                                    19


<210>  847
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  847
ctcacaggca attcgtttgt c                                                 21


<210>  848
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  848
caagcgcatc tcgatctgct cctc                                              24


<210>  849
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  849
ctttcctggc acaggagact t                                                 21


<210>  850
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  850
cacattggaa aattgacagc atagt                                             25


<210>  851
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  851
agggatattg gtgctggaaa aggcaa                                            26


<210>  852
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  852
gctcctcact aatggcctct tc                                                22


<210>  853
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  853
ggtggttata ctgtccgaaa tgtt                                              24


<210>  854
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  854
agcagcgatg tctcatatgt ccagca                                            26


<210>  855
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  855
ttgagcgtga gcaagatcct                                                   20


<210>  856
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  856
gacgctaggg tcgctgtaga a                                                 21


<210>  857
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  857
cgtggactgg gacgtgcacc a                                                 21


<210>  858
<211>  44
<212>  DNA
<213>  Homo sapiens

<400>  858
ggatacggag atccctaatg agctccccta caatgactac tttg                        44


<210>  859
<211>  44
<212>  DNA
<213>  Homo sapiens

<400>  859
caaagtagtc attgtagggg agctcattag ggatctccgt atcc                        44


<210>  860
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  860
cttatgggac tttcctactt g                                                 21


<210>  861
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  861
tcctcgccct tgctcaccat g                                                 21


<210>  862
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  862
ctcaccatgg atgatgatat cgc                                               23


<210>  863
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  863
attttctcca tgtcgtccca gttg                                              24


