
                                SEQUENCE LISTING

<110> CENTOCOR, INC.

<120> MELANOCORTIN RECEPTOR BINDING
      MIMETIBODIES, COMPOSITIONS, METHODS AND USES
  
<130> CEN5080PCT1

<140> To Be Assigned          
<141> 2008-10-30

<150> 11/929046
<151> 2007-10-30

<150> 11/257851
<151> 2005-10-25

<150> 60/621960
<151> 2004-10-25

<150> 60/972018
<151> 2007-09-13

<160> 282

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 39
<212> DNA
<213> Homo sapiens

<400> 1
tcctactcca tggagcactt ccgctggggc aagccggtg                        39

<210> 2
<211> 13
<212> PRT
<213> Homo sapiens

<400> 2
Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val
 1               5                  10              


<210> 3
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a constrained
      peptide sequence

<400> 3
agctatagct gcgaacattt tcgctggtgc aaaccggtg                        39

<210> 4
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an in vitro
      synthesized DNA

<400> 4

Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val
 1               5                  10              


<210> 5
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a constrained
      peptide sequence

<400> 5
agctattgca tggaacattt tcgctggtgc aaaccggtg                        39

<210> 6
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an In Vitro
      synthesized DNA

<400> 6
Ser Tyr Cys Met Glu His Phe Arg Trp Cys Lys Pro Val
 1               5                  10              


<210> 7
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a constrained
      peptide sequence

<400> 7
agctgcagca tggaacattt tcgctggtgc aaaccggtg                        39

<210> 8
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an In Vitro
      synthesized DNA

<400> 8
Ser Cys Ser Met Glu His Phe Arg Trp Cys Lys Pro Val
 1               5                  10              


<210> 9
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a constrained
      peptide sequence

<400> 9
tgctatagca tggaacattt tcgctggggc tgcccggtg                        39

<210> 10
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an In Vitro
      synthesized DNA

<400> 10
Cys Tyr Ser Met Glu His Phe Arg Trp Gly Cys Pro Val
 1               5                  10              


<210> 11
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a constrained
      peptide sequence

<400> 11
agctggagct gggaacattt tcgctggggc aaatggacct ggaaa                 45

<210> 12
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an In Vitro
      synthesized DNA

<400> 12
Ser Trp Ser Trp Glu His Phe Arg Trp Gly Lys Trp Thr Trp Lys
 1               5                  10                  15  


<210> 13
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a constrained
      peptide sequence

<400> 13
agctggagct ggggcgaaca ttttcgctgg ggcaaaggct ggacctggaa a          51

<210> 14
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an In Vitro
      synthesized DNA

<400> 14
Ser Trp Ser Trp Gly Glu His Phe Arg Trp Gly Lys Gly Trp Thr Trp
 1               5                  10                  15      


<210> 15
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a constrained
      peptide sequence

<400> 15
agctggagct ggggcggcga acattttcgc tggggcaaag gcggctggac ctggaaa    57

<210> 16
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an In Vitro
      synthesized DNA

<400> 16
Ser Trp Ser Trp Gly Gly Glu His Phe Arg Trp Gly Lys Gly Gly Trp
 1               5                  10                  15      


<210> 17
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a constrained
      peptide sequence

<400> 17
agctggagct ggagcatgga acattttcgc tggggcaaac cggtgtggac ctggaaa    57

<210> 18
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an In Vitro
      synthesized DNA

<400> 18
Ser Trp Ser Trp Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Trp
 1               5                  10                  15      


<210> 19
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a flexible
      peptide sequence

<400> 19
ggcagcggca gc                                                     12

<210> 20
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible peptide encoded by an In Vitro
      synthesized DNA

<400> 20
Gly Ser Gly Ser
 1              


<210> 21
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a flexible
      peptide sequence

<400> 21
ggcggcagcg gc                                                     12

<210> 22
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible peptide encoded by an In Vitro
      synthesized DNA

<400> 22
Gly Gly Ser Gly
 1              


<210> 23
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a flexible
      peptide sequence

<400> 23
ggcagcggcg gcggcagc                                               18

<210> 24
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible peptide encoded by an In Vitro
      synthesized DNA

<400> 24
Gly Ser Gly Gly Gly Ser
 1               5      


<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a flexible
      peptide sequence

<400> 25
ggcagcggcg gcggcagcgg c                                           21

<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible peptide encoded by an In Vitro
      synthesized DNA

<400> 26
Gly Ser Gly Gly Gly Ser Gly
 1               5          


<210> 27
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a flexible
      peptide sequence

<400> 27
ggcagcagcg gc                                                     12

<210> 28
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible peptide encoded by an In Vitro
      synthesized DNA

<400> 28
Gly Ser Ser Gly
 1              


<210> 29
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a flexible
      peptide sequence

<400> 29
ggcagcggcg gcggcagc                                               18

<210> 30
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible peptide encoded by an In Vitro
      synthesized DNA

<400> 30
Gly Ser Gly Gly Gly Ser
 1               5      


<210> 31
<211> 24
<212> DNA
<213> Homo sapiens

<400> 31
ggcaccctgg tgaccgtgag cagc                                        24

<210> 32
<211> 8
<212> PRT
<213> Homo sapiens

<400> 32
Gly Thr Leu Val Thr Val Ser Ser
 1               5              


<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro mutagenized homo sapien DNA encoding a V2
      peptide sequence comprising a T to A substitution
      to limit O-linked glycosylation

<400> 33
accctggtgg cggtgagcag c                                           21

<210> 34
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutagenized homo sapien V2 peptide sequence
      comprising a
      T to A substitution to limit O-linked glycosylation
      and encoded
      by an In Vitro mutagenized homo sapien DNA
      

<400> 34
Thr Leu Val Ala Val Ser Ser
 1               5          


<210> 35
<211> 45
<212> DNA
<213> Homo sapeins

<400> 35
gaaccgaaaa gctgcgataa aacccatacc tgcccgccgt gcccg                 45

<210> 36
<211> 15
<212> PRT
<213> Homo sapiens

<400> 36
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15  


<210> 37
<211> 45
<212> DNA
<213> Homo sapiens

<400> 37
gaaccgaaaa gcgcggataa aacccatacc tgcccgccgt gcccg                 45

<210> 38
<211> 15
<212> PRT
<213> Homo sapiens

<400> 38
Glu Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15  


<210> 39
<211> 36
<212> DNA
<213> Homo sapiens

<400> 39
gaaagcaaat atggcccgcc gtgcccgagc tgcccg                           36

<210> 40
<211> 12
<212> PRT
<213> Homo sapiens

<400> 40
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro
 1               5                  10          


<210> 41
<211> 36
<212> DNA
<213> Homo sapiens

<400> 41
gaaagcaaat atggcccgcc gtgcccgccg tgcccg                           36

<210> 42
<211> 12
<212> PRT
<213> Homo sapiens

<400> 42
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
 1               5                  10          


<210> 43
<211> 15
<212> DNA
<213> Homo sapiens

<400> 43
tgcccgccgt gcccg                                                  15

<210> 44
<211> 5
<212> PRT
<213> Homo sapiens

<400> 44
Cys Pro Pro Cys Pro
 1               5  


<210> 45
<211> 12
<212> DNA
<213> Homo sapiens

<400> 45
tgcccgagct gc                                                     12

<210> 46
<211> 4
<212> PRT
<213> Homo sapiens

<400> 46
Cys Pro Ser Cys
 1              


<210> 47
<211> 330
<212> DNA
<213> Homo sapiens

<400> 47
gcgccggaac tgctgggcgg cccgagcgtg tttctgtttc cgccgaaacc gaaagatacc 60
ctgatgatta gccgcacccc ggaagtgacc tgcgtggtgg tggatgtgag ccatgaagat 120
ccggaagtga aatttaactg gtatgtggat ggcgtggaag tgcataacgc gaaaaccaaa 180
ccgcgcgaag aacagtataa cagcacctat cgcgtggtga gcgtgctgac cgtgctgcat 240
caggattggc tgaacggcaa agaatataaa tgcaaagtga gcaacaaagc gctgccggcg 300
ccgattgaaa aaaccattag caaagcgaaa                                  330

<210> 48
<211> 110
<212> PRT
<213> Homo sapiens

<400> 48
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 49
<211> 330
<212> DNA
<213> Homo sapiens

<400> 49
gcgccggaag cggcgggcgg cccgagcgtg tttctgtttc cgccgaaacc gaaagatacc 60
ctgatgatta gccgcacccc ggaagtgacc tgcgtggtgg tggatgtgag ccatgaagat 120
ccggaagtga aatttaactg gtatgtggat ggcgtggaag tgcataacgc gaaaaccaaa 180
ccgcgcgaag aacagtataa cagcacctat cgcgtggtga gcgtgctgac cgtgctgcat 240
caggattggc tgaacggcaa agaatataaa tgcaaagtga gcaacaaagc gctgccggcg 300
ccgattgaaa aaaccattag caaagcgaaa                                  330

<210> 50
<211> 110
<212> PRT
<213> Homo sapiens

<400> 50
Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 51
<211> 330
<212> DNA
<213> Homo sapiens

<400> 51
gcgccggaat ttctgggcgg cccgagcgtg tttctgtttc cgccgaaacc gaaagatacc 60
ctgatgatta gccgcacccc ggaagtgacc tgcgtggtgg tggatgtgag ccaggaagat 120
ccggaagtgc agtttaactg gtatgtggat ggcgtggaag tgcataacgc gaaaaccaaa 180
ccgcgcgaag aacagtttaa cagcacctat cgcgtggtga gcgtgctgac cgtgctgcat 240
caggattggc tgaacggcaa agaatataaa tgcaaagtga gcaacaaagg cctgccgagc 300
agcattgaaa aaaccattag caaagcgaaa                                  330

<210> 52
<211> 110
<212> PRT
<213> Homo sapiens

<400> 52
Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 53
<211> 330
<212> DNA
<213> Homo sapiens

<400> 53
gcgccggaag cggcgggcgg cccgagcgtg tttctgtttc cgccgaaacc gaaagatacc 60
ctgatgatta gccgcacccc ggaagtgacc tgcgtggtgg tggatgtgag ccaggaagat 120
ccggaagtgc agtttaactg gtatgtggat ggcgtggaag tgcataacgc gaaaaccaaa 180
ccgcgcgaag aacagtttaa cagcacctat cgcgtggtga gcgtgctgac cgtgctgcat 240
caggattggc tgaacggcaa agaatataaa tgcaaagtga gcaacaaagg cctgccgagc 300
agcattgaaa aaaccattag caaagcgaaa                                  330

<210> 54
<211> 110
<212> PRT
<213> Homo sapiens

<400> 54
Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 55
<211> 321
<212> DNA
<213> Homo sapiens

<400> 55
ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa 60
aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa 120
tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc 180
gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc 240
aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc 300
ctgagcctga gcccgggcaa a                                           321

<210> 56
<211> 107
<212> PRT
<213> Homo sapiens

<400> 56
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
 1               5                  10                  15      
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            100                 105         


<210> 57
<211> 321
<212> DNA
<213> Homo sapiens

<400> 57
ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccaggaaga aatgaccaaa 60
aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa 120
tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc 180
gatggcagct tttttctgta tagccgcctg accgtggata aaagccgctg gcaggaaggc 240
aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc 300
ctgagcctga gcctgggcaa a                                           321

<210> 58
<211> 107
<212> PRT
<213> Homo sapiens

<400> 58
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
 1               5                  10                  15      
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
            100                 105         


<210> 59
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without secretory
      signal (p3024)
      
      

<400> 59
tcctactcca tggagcactt ccgctggggc aagccggtgg gatccggtgg aggctccggt 60
accttagtca ccgtctcctc agagcccaaa tcttgtgaca aaactcacac gtgcccaccg 120
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccggg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa    777

<210> 60
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH Mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3024).
      
      

<400> 60
Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Ser Gly
 1               5                  10                  15      
Gly Gly Ser Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys
            20                  25                  30          
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Pro Gly Lys
            


<210> 61
<211> 843
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a Melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal and V1
      

<400> 61
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcccag 60
atccagtcct actccatgga gcacttccgc tggggcaagc cggtgggatc cggtggaggc 120
tccggtacct tagtcaccgt ctcctcagag cccaaatctt gtgacaaaac tcacacgtgc 180
ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa 240
cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 300
agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 360
gccaagacaa agccgcggga ggagcagtac aacagcacgt accgggtggt cagcgtcctc 420
accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa 480
gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 540
caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 600
tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag 660
ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 720
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 780
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 840
aaa                                                               843

<210> 62
<211> 281
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal and V1 encoded by an in
      vitro synthesized DNA
      

<400> 62
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Gln Ile Gln Ser Tyr Ser Met Glu His Phe Arg Trp Gly
            20                  25                  30          
Lys Pro Val Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Thr Val Ser
        35                  40                  45              
Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
    50                  55                  60                  
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
65                  70                  75                  80  
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                85                  90                  95      
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            100                 105                 110         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        115                 120                 125             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    130                 135                 140                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
145                 150                 155                 160 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                165                 170                 175     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            180                 185                 190         

Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        195                 200                 205             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    210                 215                 220                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
225                 230                 235                 240 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                245                 250                 255     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            260                 265                 270         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        275                 280     


<210> 63
<211> 11978
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alha-MSH mimetibody
      
      

<400> 63
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcccag atccagtcct actccatgga 1680
gcacttccgc tggggcaagc cggtgggatc cggtggaggc tccggtacct tagtcaccgt 1740
ctcctcagag cccaaatctt gtgacaaaac tcacacgtgc ccaccgtgcc cagcacctga 1800
actcctgggg ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat 1860
ctcccggacc cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt 1920
caagttcaac tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga 1980
ggagcagtac aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg 2040
gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga 2100
gaaaaccatc tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc 2160
atcccgggat gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta 2220
tcccagcgac atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac 2280
cacgcctccc gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga 2340
caagagcagg tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca 2400
caaccactac acgcagaaga gcctctccct gtctccgggt aaatgagggc ccgtttaaac 2460
agatccagac atgataagat acattgatga gtttggacaa accacaacta gaatgcagtg 2520
aaaaaaatgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag 2580
ctgcaataaa caagttaaca acaacaattg cattcatttt atgtttcagg ttcaggggga 2640
ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa tgtggtatgg ctgattatga 2700
tccggctgcc tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg 2760
gagacggtca cagcttgtct gtaagcggat gccgggagca gacaagcccg tcaggcgtca 2820
gcgggtgttg gcgggtgtcg gggcgcagcc atgaggtcga ctctagagga tcgatgcccc 2880
gccccggacg aactaaacct gactacgaca tctctgcccc ttcttcgcgg ggcagtgcat 2940
gtaatccctt cagttggttg gtacaacttg ccaactgggc cctgttccac atgtgacacg 3000
gggggggacc aaacacaaag gggttctctg actgtagttg acatccttat aaatggatgt 3060
gcacatttgc caacactgag tggctttcat cctggagcag actttgcagt ctgtggactg 3120
caacacaaca ttgcctttat gtgtaactct tggctgaagc tcttacacca atgctggggg 3180
acatgtacct cccaggggcc caggaagact acgggaggct acaccaacgt caatcagagg 3240
ggcctgtgta gctaccgata agcggaccct caagagggca ttagcaatag tgtttataag 3300
gcccccttgt taaccctaaa cgggtagcat atgcttcccg ggtagtagta tatactatcc 3360
agactaaccc taattcaata gcatatgtta cccaacggga agcatatgct atcgaattag 3420
ggttagtaaa agggtcctaa ggaacagcga tatctcccac cccatgagct gtcacggttt 3480
tatttacatg gggtcaggat tccacgaggg tagtgaacca ttttagtcac aagggcagtg 3540
gctgaagatc aaggagcggg cagtgaactc tcctgaatct tcgcctgctt cttcattctc 3600
cttcgtttag ctaatagaat aactgctgag ttgtgaacag taaggtgtat gtgaggtgct 3660
cgaaaacaag gtttcaggtg acgcccccag aataaaattt ggacgggggg ttcagtggtg 3720
gcattgtgct atgacaccaa tataaccctc acaaacccct tgggcaataa atactagtgt 3780
aggaatgaaa cattctgaat atctttaaca atagaaatcc atggggtggg gacaagccgt 3840
aaagactgga tgtccatctc acacgaattt atggctatgg gcaacacata atcctagtgc 3900
aatatgatac tggggttatt aagatgtgtc ccaggcaggg accaagacag gtgaaccatg 3960
ttgttacact ctatttgtaa caaggggaaa gagagtggac gccgacagca gcggactcca 4020
ctggttgtct ctaacacccc cgaaaattaa acggggctcc acgccaatgg ggcccataaa 4080
caaagacaag tggccactct tttttttgaa attgtggagt gggggcacgc gtcagccccc 4140
acacgccgcc ctgcggtttt ggactgtaaa ataagggtgt aataacttgg ctgattgtaa 4200
ccccgctaac cactgcggtc aaaccacttg cccacaaaac cactaatggc accccgggga 4260
atacctgcat aagtaggtgg gcgggccaag ataggggcgc gattgctgcg atctggagga 4320
caaattacac acacttgcgc ctgagcgcca agcacagggt tgttggtcct catattcacg 4380
aggtcgctga gagcacggtg ggctaatgtt gccatgggta gcatatacta cccaaatatc 4440
tggatagcat atgctatcct aatctatatc tgggtagcat aggctatcct aatctatatc 4500
tgggtagcat atgctatcct aatctatatc tgggtagtat atgctatcct aatttatatc 4560
tgggtagcat aggctatcct aatctatatc tgggtagcat atgctatcct aatctatatc 4620
tgggtagtat atgctatcct aatctgtatc cgggtagcat atgctatcct aatagagatt 4680
agggtagtat atgctatcct aatttatatc tgggtagcat atactaccca aatatctgga 4740
tagcatatgc tatcctaatc tatatctggg tagcatatgc tatcctaatc tatatctggg 4800
tagcataggc tatcctaatc tatatctggg tagcatatgc tatcctaatc tatatctggg 4860
tagtatatgc tatcctaatt tatatctggg tagcataggc tatcctaatc tatatctggg 4920
tagcatatgc tatcctaatc tatatctggg tagtatatgc tatcctaatc tgtatccggg 4980
tagcatatgc tatcctcatg catatacagt cagcatatga tacccagtag tagagtggga 5040
gtgctatcct ttgcatatgc cgccacctcc caagggggcg tgaattttcg ctgcttgtcc 5100
ttttcctgct ggttgctccc attcttaggt gaatttaagg aggccaggct aaagccgtcg 5160
catgtctgat tgctcaccag gtaaatgtcg ctaatgtttt ccaacgcgag aaggtgttga 5220
gcgcggagct gagtgacgtg acaacatggg tatgcccaat tgccccatgt tgggaggacg 5280
aaaatggtga caagacagat ggccagaaat acaccaacag cacgcatgat gtctactggg 5340
gatttattct ttagtgcggg ggaatacacg gcttttaata cgattgaggg cgtctcctaa 5400
caagttacat cactcctgcc cttcctcacc ctcatctcca tcacctcctt catctccgtc 5460
atctccgtca tcaccctccg cggcagcccc ttccaccata ggtggaaacc agggaggcaa 5520
atctactcca tcgtcaaagc tgcacacagt caccctgata ttgcaggtag gagcgggctt 5580
tgtcataaca aggtccttaa tcgcatcctt caaaacctca gcaaatatat gagtttgtaa 5640
aaagaccatg aaataacaga caatggactc ccttagcggg ccaggttgtg ggccgggtcc 5700
aggggccatt ccaaagggga gacgactcaa tggtgtaaga cgacattgtg gaatagcaag 5760
ggcagttcct cgccttaggt tgtaaaggga ggtcttacta cctccatata cgaacacacc 5820
ggcgacccaa gttccttcgt cggtagtcct ttctacgtga ctcctagcca ggagagctct 5880
taaaccttct gcaatgttct caaatttcgg gttggaacct ccttgaccac gatgcttttc 5940
caaaccaccc tccttttttg cgccctgcct ccatcaccct gaccccgggg tccagtgctt 6000
gggccttctc ctgggtcatc tgcggggccc tgctctatcg ctcccggggg cacgtcaggc 6060
tcaccatctg ggccaccttc ttggtggtat tcaaaataat cggcttcccc tacagggtgg 6120
aaaaatggcc ttctacctgg agggggcctg cgcggtggag acccggatga tgatgactga 6180
ctactgggac tcctgggcct cttttctcca cgtccacgac ctctccccct ggctctttca 6240
cgacttcccc ccctggctct ttcacgtcct ctaccccggc ggcctccact acctcctcga 6300
ccccggcctc cactacctcc tcgaccccgg cctccactgc ctcctcgacc ccggcctcca 6360
cctcctgctc ctgcccctcc tgctcctgcc cctcctcctg ctcctgcccc tcctgcccct 6420
cctgctcctg cccctcctgc ccctcctgct cctgcccctc ctgcccctcc tgctcctgcc 6480
cctcctgccc ctcctcctgc tcctgcccct cctgcccctc ctcctgctcc tgcccctcct 6540
gcccctcctg ctcctgcccc tcctgcccct cctgctcctg cccctcctgc ccctcctgct 6600
cctgcccctc ctgctcctgc ccctcctgct cctgcccctc ctgctcctgc ccctcctgcc 6660
cctcctgccc ctcctcctgc tcctgcccct cctgctcctg cccctcctgc ccctcctgcc 6720
cctcctgctc ctgcccctcc tcctgctcct gcccctcctg cccctcctgc ccctcctcct 6780
gctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctcctgctcc tgcccctcct 6840
gcccctcctg cccctcctcc tgctcctgcc cctcctgccc ctcctcctgc tcctgcccct 6900
cctcctgctc ctgcccctcc tgcccctcct gcccctcctc ctgctcctgc ccctcctcct 6960
gctcctgccc ctcctgcccc tcctgcccct cctgcccctc ctcctgctcc tgcccctcct 7020
cctgctcctg cccctcctgc tcctgcccct cccgctcctg ctcctgctcc tgttccaccg 7080
tgggtccctt tgcagccaat gcaacttgga cgtttttggg gtctccggac accatctcta 7140
tgtcttggcc ctgatcctga gccgcccggg gctcctggtc ttccgcctcc tcgtcctcgt 7200
cctcttcccc gtcctcgtcc atggttatca ccccctcttc tttgaggtcc actgccgccg 7260
gagccttctg gtccagatgt gtctcccttc tctcctaggc catttccagg tcctgtacct 7320
ggcccctcgt cagacatgat tcacactaaa agagatcaat agacatcttt attagacgac 7380
gctcagtgaa tacagggagt gcagactcct gccccctcca acagcccccc caccctcatc 7440
cccttcatgg tcgctgtcag acagatccag gtctgaaaat tccccatcct ccgaaccatc 7500
ctcgtcctca tcaccaatta ctcgcagccc ggaaaactcc cgctgaacat cctcaagatt 7560
tgcgtcctga gcctcaagcc aggcctcaaa ttcctcgtcc ccctttttgc tggacggtag 7620
ggatggggat tctcgggacc cctcctcttc ctcttcaagg tcaccagaca gagatgctac 7680
tggggcaacg gaagaaaagc tgggtgcggc ctgtgaggat cagcttatcg atgataagct 7740
gtcaaacatg agaattcttg aagacgaaag ggcctcgtga tacgcctatt tttataggtt 7800
aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc 7860
ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa 7920
taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc 7980
cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa 8040
acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa 8100
ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg 8160
atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtgttga cgccgggcaa 8220
gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc 8280
acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc 8340
atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta 8400
accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag 8460
ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgcagc aatggcaaca 8520
acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata 8580
gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc 8640
tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca 8700
ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca 8760
actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg 8820
taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa 8880
tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt 8940
gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat 9000
cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg 9060
gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga 9120
gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac 9180
tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt 9240
ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag 9300
cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc 9360
gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag 9420
gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca 9480
gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt 9540
cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc 9600
tttttacggt tcctggcctt ttgctggcct tgaagctgtc cctgatggtc gtcatctacc 9660
tgcctggaca gcatggcctg caacgcgggc atcccgatgc cgccggaagc gagaagaatc 9720
ataatgggga aggccatcca gcctcgcgtc gcgaacgcca gcaagacgta gcccagcgcg 9780
tcggccccga gatgcgccgc gtgcggctgc tggagatggc ggacgcgatg gatatgttct 9840
gccaagggtt ggtttgcgca ttcacagttc tccgcaagaa ttgattggct ccaattcttg 9900
gagtggtgaa tccgttagcg aggtgccgcc ctgcttcatc cccgtggccc gttgctcgcg 9960
tttgctggcg gtgtccccgg aagaaatata tttgcatgtc tttagttcta tgatgacaca 10020
aaccccgccc agcgtcttgt cattggcgaa ttcgaacacg cagatgcagt cggggcggcg 10080
cggtccgagg tccacttcgc atattaaggt gacgcgtgtg gcctcgaaca ccgagcgacc 10140
ctgcagcgac ccgcttaaca gcgtcaacag cgtgccgcag atcccggggg gcaatgagat 10200
atgaaaaagc ctgaactcac cgcgacgtct gtcgagaagt ttctgatcga aaagttcgac 10260
agcgtctccg acctgatgca gctctcggag ggcgaagaat ctcgtgcttt cagcttcgat 10320
gtaggagggc gtggatatgt cctgcgggta aatagctgcg ccgatggttt ctacaaagat 10380
cgttatgttt atcggcactt tgcatcggcc gcgctcccga ttccggaagt gcttgacatt 10440
ggggaattca gcgagagcct gacctattgc atctcccgcc gtgcacaggg tgtcacgttg 10500
caagacctgc ctgaaaccga actgcccgct gttctgcagc cggtcgcgga ggccatggat 10560
gcgatcgctg cggccgatct tagccagacg agcgggttcg gcccattcgg accgcaagga 10620
atcggtcaat acactacatg gcgtgatttc atatgcgcga ttgctgatcc ccatgtgtat 10680
cactggcaaa ctgtgatgga cgacaccgtc agtgcgtccg tcgcgcaggc tctcgatgag 10740
ctgatgcttt gggccgagga ctgccccgaa gtccggcacc tcgtgcacgc ggatttcggc 10800
tccaacaatg tcctgacgga caatggccgc ataacagcgg tcattgactg gagcgaggcg 10860
atgttcgggg attcccaata cgaggtcgcc aacatcttct tctggaggcc gtggttggct 10920
tgtatggagc agcagacgcg ctacttcgag cggaggcatc cggagcttgc aggatcgccg 10980
cggctccggg cgtatatgct ccgcattggt cttgaccaac tctatcagag cttggttgac 11040
ggcaatttcg atgatgcagc ttgggcgcag ggtcgatgcg acgcaatcgt ccgatccgga 11100
gccgggactg tcgggcgtac acaaatcgcc cgcagaagcg cggccgtctg gaccgatggc 11160
tgtgtagaag tactcgccga tagtggaaac cgacgcccca gcactcgtcc ggatcgggag 11220
atgggggagg ctaactgaaa cacggaagga gacaataccg gaaggaaccc gcgctatgac 11280
ggcaataaaa agacagaata aaacgcacgg gtgttgggtc gtttgttcat aaacgcgggg 11340
ttcggtccca gggctggcac tctgtcgata ccccaccgag accccattgg ggccaatacg 11400
cccgcgtttc ttccttttcc ccaccccacc ccccaagttc gggtgaaggc ccagggctcg 11460
cagccaacgt cggggcggca ggccctgcca tagccactgg ccccgtgggt tagggacggg 11520
gtcccccatg gggaatggtt tatggttcgt gggggttatt attttgggcg ttgcgtgggg 11580
tcaggtccac gactggactg agcagacaga cccatggttt ttggatggcc tgggcatgga 11640
ccgcatgtac tggcgcgaca cgaacaccgg gcgtctgtgg ctgccaaaca cccccgaccc 11700
ccaaaaacca ccgcgcggat ttctggcgtg ccaagctagt cgaccaattc tcatgtttga 11760
cagcttatca tcgcagatcc gggcaacgtt gttgccattg ctgcaggcgc agaactggta 11820
ggtatggaag atctatacat tgaatcaata ttggcaatta gccatattag tcattggtta 11880
tatagcataa atcaatattg gctattggcc attgcatacg ttgtatctat atcataatat 11940
gtacatttat attggctcat gtccaatatg accgccat                         11978



<210> 64
<211> 696
<212> DNA
<213> Homo sapiens

<400> 64
gaaccgaaaa gctgcgataa aacccatacc tgcccgccgt gcccggcgcc ggaactgctg 60
ggcggcccga gcgtgtttct gtttccgccg aaaccgaaag ataccctgat gattagccgc 120
accccggaag tgacctgcgt ggtggtggat gtgagccatg aagatccgga agtgaaattt 180
aactggtatg tggatggcgt ggaagtgcat aacgcgaaaa ccaaaccgcg cgaagaacag 240
tataacagca cctatcgcgt ggtgagcgtg ctgaccgtgc tgcatcagga ttggctgaac 300
ggcaaagaat ataaatgcaa agtgagcaac aaagcgctgc cggcgccgat tgaaaaaacc 360
attagcaaag cgaaaggcca gccgcgcgaa ccgcaggtgt ataccctgcc gccgagccgc 420
gatgaactga ccaaaaacca ggtgagcctg acctgcctgg tgaaaggctt ttatccgagc 480
gatattgcgg tggaatggga aagcaacggc cagccggaaa acaactataa aaccaccccg 540
ccggtgctgg atagcgatgg cagctttttt ctgtatagca aactgaccgt ggataaaagc 600
cgctggcagc agggcaacgt gtttagctgc agcgtgatgc atgaagcgct gcataaccat 660
tatacccaga aaagcctgag cctgagcccg ggcaaa                           696

<210> 65
<211> 232
<212> PRT
<213> Homo sapiens

<400> 65
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys
225                 230         


<210> 66
<211> 45
<212> DNA
<213> Homo sapiens

<400> 66
atgattagcc gcaccccgac cgtgctgcat cagcataacc attat                 45

<210> 67
<211> 15
<212> PRT
<213> Homo sapiens

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody
      
      

<400> 67
Met Ile Ser Arg Thr Pro Thr Val Leu His Gln His Asn His Tyr
 1               5                  10                  15  


<210> 68
<211> 57
<212> DNA
<213> Homo sapiens

<400> 68
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcc    57

<210> 69
<211> 19
<212> PRT
<213> Homo sapiens

<400> 69
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala
            


<210> 70
<211> 951
<212> DNA
<213> Homo sapiens

<400> 70
atggctgtgc agggatccca gagaagactt ctgggctccc tcaactccac ccccacagcc 60
atcccccagc tggggctggc tgccaaccag acaggagccc ggtgcctgga ggtgtccatc 120
tctgacgggc tcttcctcag cctggggctg gtgagcttgg tggagaacgc gctggtggtg 180
gccaccatcg ccaagaaccg gaacctgcac tcacccatgt actgcttcat ctgctgcctg 240
gccttgtcgg acctgctggt gagcgggagc aacgtgctgg agacggccgt catcctcctg 300
ctggaggccg gtgcactggt ggcccgggct gcggtgctgc agcagctgga caatgtcatt 360
gacgtgatca cctgcagctc catgctgtcc agcctctgct tcctgggcgc catcgccgtg 420
gaccgctaca tctccatctt ctacgcactg cgctaccaca gcaccgtgac cctgccgcgg 480
gcgcggcgag ccgttgcggc catctgggtg gccagtgtcg tcttcagcac gctcttcatc 540
gcctactacg accacgtggc cgtcctgctg tgcctcgtgg tcttcttcct ggctatgctg 600
gtgctcatgg ccgtgctgta cgtccacatg ctggcccggg cctgccagca cgcccagggc 660
atcgcccggc tccacaagag gcagcgcccg gtccaccagg gctttggcct taaaggcgct 720
gtcaccctca ccatcctgct gggcattttc ttcctctgct ggggcccctt cttcctgcat 780
ctcacactca tcgtcctctg ccccgagcac cccacgtgcg gctgcatctt caagaacttc 840
aacctctttc tcgccctcat catctgcaat gccatcatcg accccctcat ctacgccttc 900
cacagccagg agctccgcag gacgctcaag gaggtgctga cgtgctcctg g          951

<210> 71
<211> 317
<212> PRT
<213> Homo sapiens

<400> 71
Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser
 1               5                  10                  15      
Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly
            20                  25                  30          
Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu
        35                  40                  45              
Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala
    50                  55                  60                  
Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu
65                  70                  75                  80  
Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala
                85                  90                  95      
Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val
            100                 105                 110         
Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met
        115                 120                 125             
Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile
    130                 135                 140                 
Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Thr Val Thr Leu Pro Arg
145                 150                 155                 160 
Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser
                165                 170                 175     
Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu
            180                 185                 190         
Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val
        195                 200                 205             
His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu
    210                 215                 220                 
His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala
225                 230                 235                 240 
Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro
                245                 250                 255     

Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr
            260                 265                 270         
Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile
        275                 280                 285             
Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu
    290                 295                 300                 
Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp
305                 310                 315         


<210> 72
<211> 891
<212> DNA
<213> Homo sapiens

<400> 72
atgaagcaca ttatcaactc gtatgaaaac atcaacaaca cagcaagaaa taattccgac 60
tgtcctcgtg tggttttgcc ggaggagata tttttcacaa tttccattgt tggagttttg 120
gagaatctga tcgtcctgct ggctgtgttc aagaataaga atctccaggc acccatgtac 180
tttttcatct gtagcttggc catatctgat atgctgggca gcctatataa gatcttggaa 240
aatatcctga tcatattgag aaacatgggc tatctcaagc cacgtggcag ttttgaaacc 300
acagccgatg acatcatcga ctccctgttt gtcctctccc tgcttggctc catcttcagc 360
ctgtctgtga ttgctgcgga ccgctacatc accatcttcc acgcactgcg gtaccacagc 420
atcgtgacca tgcgccgcac tgtggtggtg cttacggtca tctggacgtt ctgcacgggg 480
actggcatca ccatggtgat cttctcccat catgtgccca cagtgatcac cttcacgtcg 540
ctgttcccgc tgatgctggt cttcatcctg tgcctctatg tgcacatgtt cctgctggct 600
cgatcccaca ccaggaagat ctccaccctc cccagagcca acatgaaagg ggccatcaca 660
ctgaccatcc tgctcggggt cttcatcttc tgctgggccc cctttgtgct tcatgtcctc 720
ttgatgacat tctgcccaag taacccctac tgcgcctgct acatgtctct cttccaggtg 780
aacggcatgt tgatcatgtg caatgccgtc attgacccct tcatatatgc cttccggagc 840
ccagagctca gggacgcatt caaaaagatg atcttctgca gcaggtactg g          891

<210> 73
<211> 297
<212> PRT
<213> Homo sapiens

<400> 73
Met Lys His Ile Ile Asn Ser Tyr Glu Asn Ile Asn Asn Thr Ala Arg
 1               5                  10                  15      
Asn Asn Ser Asp Cys Pro Arg Val Val Leu Pro Glu Glu Ile Phe Phe
            20                  25                  30          
Thr Ile Ser Ile Val Gly Val Leu Glu Asn Leu Ile Val Leu Leu Ala
        35                  40                  45              
Val Phe Lys Asn Lys Asn Leu Gln Ala Pro Met Tyr Phe Phe Ile Cys
    50                  55                  60                  
Ser Leu Ala Ile Ser Asp Met Leu Gly Ser Leu Tyr Lys Ile Leu Glu
65                  70                  75                  80  
Asn Ile Leu Ile Ile Leu Arg Asn Met Gly Tyr Leu Lys Pro Arg Gly
                85                  90                  95      
Ser Phe Glu Thr Thr Ala Asp Asp Ile Ile Asp Ser Leu Phe Val Leu
            100                 105                 110         
Ser Leu Leu Gly Ser Ile Phe Ser Leu Ser Val Ile Ala Ala Asp Arg
        115                 120                 125             
Tyr Ile Thr Ile Phe His Ala Leu Arg Tyr His Ser Ile Val Thr Met
    130                 135                 140                 

Arg Arg Thr Val Val Val Leu Thr Val Ile Trp Thr Phe Cys Thr Gly
145                 150                 155                 160 
Thr Gly Ile Thr Met Val Ile Phe Ser His His Val Pro Thr Val Ile
                165                 170                 175     
Thr Phe Thr Ser Leu Phe Pro Leu Met Leu Val Phe Ile Leu Cys Leu
            180                 185                 190         
Tyr Val His Met Phe Leu Leu Ala Arg Ser His Thr Arg Lys Ile Ser
        195                 200                 205             
Thr Leu Pro Arg Ala Asn Met Lys Gly Ala Ile Thr Leu Thr Ile Leu
    210                 215                 220                 
Leu Gly Val Phe Ile Phe Cys Trp Ala Pro Phe Val Leu His Val Leu
225                 230                 235                 240 
Leu Met Thr Phe Cys Pro Ser Asn Pro Tyr Cys Ala Cys Tyr Met Ser
                245                 250                 255     
Leu Phe Gln Val Asn Gly Met Leu Ile Met Cys Asn Ala Val Ile Asp
            260                 265                 270         
Pro Phe Ile Tyr Ala Phe Arg Ser Pro Glu Leu Arg Asp Ala Phe Lys
        275                 280                 285             
Lys Met Ile Phe Cys Ser Arg Tyr Trp
    290                 295         


<210> 74
<211> 1080
<212> DNA
<213> Homo sapiens

<400> 74
atgagcatcc aaaagacgta tctggaggga gattttgtct ttcctgtgag cagcagcagc 60
ttcctacgga ccctgctgga gccccagctc ggatcagccc ttctgacagc aatgaatgct 120
tcgtgctgcc tgccctctgt tcagccaaca ctgcctaatg gctcggagca cctccaagcc 180
cctttcttca gcaaccagag cagcagcgcc ttctgtgagc aggtcttcat caagcccgag 240
gttttcctgt ctctgggcat cgtcagtctg ctggaaaaca tcctggttat cctggccgtg 300
gtcaggaacg gcaacctgca ctccccgatg tacttctttc tctgcagcct ggcggtggcc 360
gacatgctgg taagtgtgtc caatgccctg gagaccatca tgatcgccat cgtccacagc 420
gactacctga ccttcgagga ccagtttatc cagcacatgg acaacatctt cgactccatg 480
atctgcatct ccctggtggc ctccatctgc aacctcctgg ccatcgccgt cgacaggtac 540
gtcaccatct tttacgcgct ccgctaccac agcatcatga ccgtgaggaa ggccctcacc 600
ttgatcgtgg ccatctgggt ctgctgcggc gtctgtggcg tggtgttcat cgtctactcg 660
gagagcaaaa tggtcattgt gtgcctcatc accatgttct tcgccatgat gctcctcatg 720
ggcaccctct acgtgcacat gttcctcttt gcgcggctgc acgtcaagcg catagcagca 780
ctgccacctg ccgacggggt ggccccacag caacactcat gcatgaaggg ggcagtcacc 840
atcaccattc tcctgggcgt gttcatcttc tgctgggccc ccttcttcct ccacctggtc 900
ctcatcatca cctgccccac caacccctac tgcatctgct acactgccca cttcaacacc 960
tacctggtcc tcatcatgtg caactccgtc atcgacccac tcatctacgc tttccggagc 1020
ctggaattgc gcaacacctt tagggagatt ctctgtggct gcaacggcat gaacttggga 1080


<210> 75
<211> 360
<212> PRT
<213> Homo sapiens

<400> 75
Met Ser Ile Gln Lys Thr Tyr Leu Glu Gly Asp Phe Val Phe Pro Val
 1               5                  10                  15      

Ser Ser Ser Ser Phe Leu Arg Thr Leu Leu Glu Pro Gln Leu Gly Ser
            20                  25                  30          
Ala Leu Leu Thr Ala Met Asn Ala Ser Cys Cys Leu Pro Ser Val Gln
        35                  40                  45              
Pro Thr Leu Pro Asn Gly Ser Glu His Leu Gln Ala Pro Phe Phe Ser
    50                  55                  60                  
Asn Gln Ser Ser Ser Ala Phe Cys Glu Gln Val Phe Ile Lys Pro Glu
65                  70                  75                  80  
Val Phe Leu Ser Leu Gly Ile Val Ser Leu Leu Glu Asn Ile Leu Val
                85                  90                  95      
Ile Leu Ala Val Val Arg Asn Gly Asn Leu His Ser Pro Met Tyr Phe
            100                 105                 110         
Phe Leu Cys Ser Leu Ala Val Ala Asp Met Leu Val Ser Val Ser Asn
        115                 120                 125             
Ala Leu Glu Thr Ile Met Ile Ala Ile Val His Ser Asp Tyr Leu Thr
    130                 135                 140                 
Phe Glu Asp Gln Phe Ile Gln His Met Asp Asn Ile Phe Asp Ser Met
145                 150                 155                 160 
Ile Cys Ile Ser Leu Val Ala Ser Ile Cys Asn Leu Leu Ala Ile Ala
                165                 170                 175     
Val Asp Arg Tyr Val Thr Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile
            180                 185                 190         
Met Thr Val Arg Lys Ala Leu Thr Leu Ile Val Ala Ile Trp Val Cys
        195                 200                 205             
Cys Gly Val Cys Gly Val Val Phe Ile Val Tyr Ser Glu Ser Lys Met
    210                 215                 220                 
Val Ile Val Cys Leu Ile Thr Met Phe Phe Ala Met Met Leu Leu Met
225                 230                 235                 240 
Gly Thr Leu Tyr Val His Met Phe Leu Phe Ala Arg Leu His Val Lys
                245                 250                 255     
Arg Ile Ala Ala Leu Pro Pro Ala Asp Gly Val Ala Pro Gln Gln His
            260                 265                 270         
Ser Cys Met Lys Gly Ala Val Thr Ile Thr Ile Leu Leu Gly Val Phe
        275                 280                 285             
Ile Phe Cys Trp Ala Pro Phe Phe Leu His Leu Val Leu Ile Ile Thr
    290                 295                 300                 
Cys Pro Thr Asn Pro Tyr Cys Ile Cys Tyr Thr Ala His Phe Asn Thr
305                 310                 315                 320 
Tyr Leu Val Leu Ile Met Cys Asn Ser Val Ile Asp Pro Leu Ile Tyr
                325                 330                 335     
Ala Phe Arg Ser Leu Glu Leu Arg Asn Thr Phe Arg Glu Ile Leu Cys
            340                 345                 350         
Gly Cys Asn Gly Met Asn Leu Gly
        355                 360 


<210> 76
<211> 999
<212> DNA
<213> Homo sapiens

<400> 76
atggtgaact ccacccaccg tgggatgcac acttctctgc acctctggaa ccgcagcagt 60
tacagactgc acagcaatgc cagtgagtcc cttggaaaag gctactctga tggagggtgc 120
tacgagcaac tttttgtctc tcctgaggtg tttgtgactc tgggtgtcat cagcttgttg 180
gagaatatct tagtgattgt ggcaatagcc aagaacaaga atctgcattc acccatgtac 240
tttttcatct gcagcttggc tgtggctgat atgctggtga gcgtttcaaa tggatcagaa 300
accattatca tcaccctatt aaacagtaca gatacggatg cacagagttt cacagtgaat 360
attgataatg tcattgactc ggtgatctgt agctccttgc ttgcatccat ttgcagcctg 420
ctttcaattg cagtggacag gtactttact atcttctatg ctctccagta ccataacatt 480
atgacagtta agcgggttgg gatcatcata agttgtatct gggcagcttg cacggtttca 540
ggcattttgt tcatcattta ctcagatagt agtgctgtca tcatctgcct catcaccatg 600
ttcttcacca tgctggctct catggcttct ctctatgtcc acatgttcct gatggccagg 660
cttcacatta agaggattgc tgtcctcccc ggcactggtg ccatccgcca aggtgccaat 720
atgaagggag cgattacctt gaccatcctg attggcgtct ttgttgtctg ctgggcccca 780
ttcttcctcc acttaatatt ctacatctct tgtcctcaga atccatattg tgtgtgcttc 840
atgtctcact ttaacttgta tctcatactg atcatgtgta attcaatcat cgatcctctg 900
atttatgcac tccggagtca agaactgagg aaaaccttca aagagatcat ctgttgctat 960
cccctgggag gcctttgtga cttgtctagc agatattaa                        999

<210> 77
<211> 332
<212> PRT
<213> Homo sapiens

<400> 77
Met Val Asn Ser Thr His Arg Gly Met His Thr Ser Leu His Leu Trp
 1               5                  10                  15      
Asn Arg Ser Ser Tyr Arg Leu His Ser Asn Ala Ser Glu Ser Leu Gly
            20                  25                  30          
Lys Gly Tyr Ser Asp Gly Gly Cys Tyr Glu Gln Leu Phe Val Ser Pro
        35                  40                  45              
Glu Val Phe Val Thr Leu Gly Val Ile Ser Leu Leu Glu Asn Ile Leu
    50                  55                  60                  
Val Ile Val Ala Ile Ala Lys Asn Lys Asn Leu His Ser Pro Met Tyr
65                  70                  75                  80  
Phe Phe Ile Cys Ser Leu Ala Val Ala Asp Met Leu Val Ser Val Ser
                85                  90                  95      
Asn Gly Ser Glu Thr Ile Ile Ile Thr Leu Leu Asn Ser Thr Asp Thr
            100                 105                 110         
Asp Ala Gln Ser Phe Thr Val Asn Ile Asp Asn Val Ile Asp Ser Val
        115                 120                 125             
Ile Cys Ser Ser Leu Leu Ala Ser Ile Cys Ser Leu Leu Ser Ile Ala
    130                 135                 140                 
Val Asp Arg Tyr Phe Thr Ile Phe Tyr Ala Leu Gln Tyr His Asn Ile
145                 150                 155                 160 
Met Thr Val Lys Arg Val Gly Ile Ile Ile Ser Cys Ile Trp Ala Ala
                165                 170                 175     
Cys Thr Val Ser Gly Ile Leu Phe Ile Ile Tyr Ser Asp Ser Ser Ala
            180                 185                 190         
Val Ile Ile Cys Leu Ile Thr Met Phe Phe Thr Met Leu Ala Leu Met
        195                 200                 205             
Ala Ser Leu Tyr Val His Met Phe Leu Met Ala Arg Leu His Ile Lys
    210                 215                 220                 
Arg Ile Ala Val Leu Pro Gly Thr Gly Ala Ile Arg Gln Gly Ala Asn
225                 230                 235                 240 
Met Lys Gly Ala Ile Thr Leu Thr Ile Leu Ile Gly Val Phe Val Val
                245                 250                 255     
Cys Trp Ala Pro Phe Phe Leu His Leu Ile Phe Tyr Ile Ser Cys Pro
            260                 265                 270         
Gln Asn Pro Tyr Cys Val Cys Phe Met Ser His Phe Asn Leu Tyr Leu
        275                 280                 285             
Ile Leu Ile Met Cys Asn Ser Ile Ile Asp Pro Leu Ile Tyr Ala Leu
    290                 295                 300                 
Arg Ser Gln Glu Leu Arg Lys Thr Phe Lys Glu Ile Ile Cys Cys Tyr
305                 310                 315                 320 
Pro Leu Gly Gly Leu Cys Asp Leu Ser Ser Arg Tyr
                325                 330         


<210> 78
<211> 975
<212> DNA
<213> Homo sapiens

<400> 78
atgaattcct catttcacct gcatttcttg gatctcaacc tgaatgccac agagggcaac 60
ctttcaggac ccaatgtcaa aaacaagtct tcaccatgtg aagacatggg cattgctgtg 120
gaggtgtttc tcactctggg tgtcatcagc ctcttggaga acatcttggt cataggggcc 180
atagtgaaga acaaaaacct gcactccccc atgtacttct tcgtgtgcag cctggcagtg 240
gcggacatgc tggtgagcat gtccagtgcc tgggagacca tcaccatcta cctactcaac 300
aacaagcacc tagtgatagc agacgccttt gtgcgccaca ttgacaatgt gtttgactcc 360
atgatctgca tttccgtggt ggcatccatg tgcagcttac tggccattgc agtggatagg 420
tacgtcacca tcttctacgc cctgcgctac caccacatca tgacggcgag gcgctcaggg 480
gccatcatcg ccggcatctg ggctttctgc acgggctgcg gcattgtctt catcctgtac 540
tcagaatcca cctacgtcat cctgtgcctc atctccatgt tcttcgctat gctgttcctc 600
ctggtgtctc tgtacataca catgttcctc ctggcgcgga ctcacgtcaa gcggatcgcg 660
gctctgcccg gggccagctc tgcgcggcag aggaccagca tgcagggcgc ggtcaccgtc 720
accatgctgc tgggcgtgtt taccgtgtgc tgggccccgt tcttccttca tctcacttta 780
atgctttctt gccctcagaa cctctactgc tctcgcttca tgtctcactt caatatgtac 840
ctcatactca tcatgtgtaa ttccgtgatg gaccctctca tatatgcctt ccgcagccaa 900
gagatgcgga agacctttaa ggagattatt tgctgccgtg gtttcaggat cgcctgcagc 960
tttcccagaa gggat                                                  975

<210> 79
<211> 325
<212> PRT
<213> Homo sapiens

<400> 79
Met Asn Ser Ser Phe His Leu His Phe Leu Asp Leu Asn Leu Asn Ala
 1               5                  10                  15      
Thr Glu Gly Asn Leu Ser Gly Pro Asn Val Lys Asn Lys Ser Ser Pro
            20                  25                  30          
Cys Glu Asp Met Gly Ile Ala Val Glu Val Phe Leu Thr Leu Gly Val
        35                  40                  45              
Ile Ser Leu Leu Glu Asn Ile Leu Val Ile Gly Ala Ile Val Lys Asn
    50                  55                  60                  
Lys Asn Leu His Ser Pro Met Tyr Phe Phe Val Cys Ser Leu Ala Val
65                  70                  75                  80  
Ala Asp Met Leu Val Ser Met Ser Ser Ala Trp Glu Thr Ile Thr Ile
                85                  90                  95      
Tyr Leu Leu Asn Asn Lys His Leu Val Ile Ala Asp Ala Phe Val Arg
            100                 105                 110         
His Ile Asp Asn Val Phe Asp Ser Met Ile Cys Ile Ser Val Val Ala
        115                 120                 125             
Ser Met Cys Ser Leu Leu Ala Ile Ala Val Asp Arg Tyr Val Thr Ile
    130                 135                 140                 
Phe Tyr Ala Leu Arg Tyr His His Ile Met Thr Ala Arg Arg Ser Gly
145                 150                 155                 160 

Ala Ile Ile Ala Gly Ile Trp Ala Phe Cys Thr Gly Cys Gly Ile Val
                165                 170                 175     
Phe Ile Leu Tyr Ser Glu Ser Thr Tyr Val Ile Leu Cys Leu Ile Ser
            180                 185                 190         
Met Phe Phe Ala Met Leu Phe Leu Leu Val Ser Leu Tyr Ile His Met
        195                 200                 205             
Phe Leu Leu Ala Arg Thr His Val Lys Arg Ile Ala Ala Leu Pro Gly
    210                 215                 220                 
Ala Ser Ser Ala Arg Gln Arg Thr Ser Met Gln Gly Ala Val Thr Val
225                 230                 235                 240 
Thr Met Leu Leu Gly Val Phe Thr Val Cys Trp Ala Pro Phe Phe Leu
                245                 250                 255     
His Leu Thr Leu Met Leu Ser Cys Pro Gln Asn Leu Tyr Cys Ser Arg
            260                 265                 270         
Phe Met Ser His Phe Asn Met Tyr Leu Ile Leu Ile Met Cys Asn Ser
        275                 280                 285             
Val Met Asp Pro Leu Ile Tyr Ala Phe Arg Ser Gln Glu Met Arg Lys
    290                 295                 300                 
Thr Phe Lys Glu Ile Ile Cys Cys Arg Gly Phe Arg Ile Ala Cys Ser
305                 310                 315                 320 
Phe Pro Arg Arg Asp
                325 


<210> 80
<211> 12
<212> DNA
<213> Homo sapiens

<400> 80
cattttcgct gg                                                     12

<210> 81
<211> 4
<212> PRT
<213> Homo sapiens

<400> 81
His Phe Arg Trp
 1              


<210> 82
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> In Vitro synthesized DNA encoding a peptide that
      is a modification of alpha-MSH HFRW core amino
      acid sequence
      
      
      

<400> 82
tttcattgga tg                                                     12

<210> 83
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> A peptide that is a modification of alpha-MSH HFRW
      core amino acid sequence and is encoded by an in
      vitro synthesized DNA

<400> 83
Phe His Trp Met
 1              


<210> 84
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a flexible
      peptide sequence
      
<400> 84
ggcggcggca gc                                                     12

<210> 85
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible peptide encoded by an in vitro
      synthesized DNA
      
<400> 85
Gly Gly Gly Ser
 1              


<210> 86
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a constrained
      peptide sequence
      
<400> 86
tcctactgcg gcgagcactt ccgctggggc tgcccggtg                        39

<210> 87
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an in vitro
      synthesized DNA.
<400> 87
Ser Tyr Cys Gly Glu His Phe Arg Trp Gly Cys Pro Val
 1               5                  10              


<210> 88
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a constrained
      peptide sequence.
      
<400> 88
tcctactcct gcgagcactt ccgctggggc aagccgtgc                        39

<210> 89
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an in vitro
      synthesized DNA.

<400> 89
Ser Tyr Ser Cys Glu His Phe Arg Trp Gly Lys Pro Cys
 1               5                  10              


<210> 90
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a constrained
      peptide sequence.
      

<400> 90
tcctactgca tggagcactt ccgctggggc tgcccggtg                        39

<210> 91
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an in vitro
      synthesized DNA.
      

<400> 91

Ser Tyr Cys Met Glu His Phe Arg Trp Gly Cys Pro Val
 1               5                  10              


<210> 92
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a constrained
      peptide sequence.
      

<400> 92
tcctgctcca tggagcactt ccgctggggc tgcccggtg                        39

<210> 93
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an in vitro
      synthesized DNA.
      

<400> 93
Ser Cys Ser Met Glu His Phe Arg Trp Gly Cys Pro Val
 1               5                  10              


<210> 94
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a constrained
      peptide sequence.
      

<400> 94
tcctactcct gcgagcactt ccgctggggc tgcccggtg                        39

<210> 95
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an in vitro
      synthesized DNA.
      

<400> 95
Ser Tyr Ser Cys Glu His Phe Arg Trp Gly Cys Pro Val
 1               5                  10              


<210> 96
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a constrained
      peptide sequence.

<400> 96
tcctactcct gcgagcactt ccgctggggc aagtgcgtg                        39

<210> 97
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an in vitro
      synthesized DNA.

<400> 97
Ser Tyr Ser Cys Glu His Phe Arg Trp Gly Lys Cys Val
 1               5                  10              


<210> 98
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a flexible
      peptide sequence.

<400> 98
ggaggaggcg gatcc                                                  15

<210> 99
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible peptide encoded by an in vitro
      synthesized DNA.

<400> 99
Gly Gly Gly Gly Ser
 1               5  


<210> 100
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a flexible
      peptide sequence.

<400> 100
ggaggcggag gaagcggcgg aggcggatcc                                  30

<210> 101
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible peptide encoded by an in vitro
      synthesized DNA.

<400> 101
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10  


<210> 102
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a flexible
      peptide sequence.

<400> 102
gggggcggag gaagcggcgg aggcgggagc ggcggcggag gatcc                 45

<210> 103
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible peptide encoded by an in vitro
      synthesized DNA.

<400> 103
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 104
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a flexible
      peptide sequence.

<400> 104
gggggcggag gaagcggcgg aggcgggagc ggcggcggag gctccggtgg cggaggatcc 60


<210> 105
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible peptide encoded by an in vitro
      synthesized DNA.

<400> 105
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
 1               5                  10                  15      
Gly Gly Gly Ser
            20  


<210> 106
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro mutagenized Homo sapien DNA encoding a Hg
      peptide sequence comprising a T to A substitution to
      limit O-linked glycosylation.

<400> 106
gagcccaaat cttgtgacaa aactcacgcc tgcccaccgt gccca                 45

<210> 107
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutagenized Homo sapien Hg peptide sequence
      comprising a T to A substitution to limit O-linked
      glycosylation this is encoded by an in vitro
      mutagenized Homo sapien DNA.

<400> 107
Glu Pro Lys Ser Cys Asp Lys Thr His Ala Cys Pro Pro Cys Pro
 1               5                  10                  15  


<210> 108
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro mutagenized Homo sapien DNA encoding a Hg
      peptide sequence comprising a C to A substitution to
      limit aggregation or multimerization.

<400> 108
gagcccaaat ctgccgacaa aactcacacg tgcccaccgt gccca                 45

<210> 109
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutagenized Homo sapien Hg peptide sequence
      comprising a C to A substitution to limit aggregation
      or multimerization that is encoded by an in vitro
      mutagenized Homo sapien DNA.

<400> 109
Glu Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15  


<210> 110
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro mutagenized Homo sapien DNA encoding a Hg
      peptide sequence comprising a C to A substitution to
      limit aggregation or multimerization and a T to A
      substitution to limit O-linked glycosylation.

<400> 110
gagcccaaat ctgccgacaa aactcacgcc tgcccaccgt gccca                 45

<210> 111
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutagenized Homo sapien Hg peptide sequence
      comprising a C to A substitution to limit aggregation
      or multimerization and a T to A substitution to limit
      O-linked glycosylation.  The peptide is encoded by
      an in vitro mutagenized Homo sapien DNA.

<400> 111
Glu Pro Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro Cys Pro
 1               5                  10                  15  


<210> 112
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding an amino
      terminal portion of an immunoglobulin variable
      region that has been modified for increased
      flexibility by the addition of G residues.

<400> 112
cagatccagg gaggc                                                  15

<210> 113
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino terminal portion of an immunoglobulin
      variable region peptide that has been modified for
      increased flexibility by the addition of G
      residues.  The peptide is encoded by an in vitro
      synthesized DNA.

<400> 113
Gln Ile Gln Gly Gly
 1               5  


<210> 114
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding an amino
      terminal portion of an immunoglobulin variable
      region that has been modified for increased
      flexibility by the addition of G residues.
      
      

<400> 114
cagatccagg gaggcggagg c                                           21

<210> 115
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Amino terminal portion of an immunoglobulin
      variable region peptide that has been modified for
      increased flexibility by the addition of G
      residues.  The peptide is encoded by an in vitro
      synthesized DNA.
      
      

<400> 115
Gln Ile Gln Gly Gly Gly Gly
 1               5          


<210> 116
<211> 330
<212> DNA
<213> Homo sapiens

<400> 116
gcgcctgagg ccgccggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact 60
ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac 120
cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag 180
ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac 240
caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc 300
tccatcgaga aaaccatctc caaagccaaa                                  330

<210> 117
<211> 110
<212> PRT
<213> Homo sapiens

<400> 117
Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 118
<211> 321
<212> DNA
<213> Homo sapiens

<400> 118
gggcagcctc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag 60
aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag 120
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 180
gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg 240
aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaaaagc 300
ttgtccctgt ctctgggtaa a                                           321

<210> 119
<211> 107
<212> PRT
<213> Homo sapiens

<400> 119
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
 1               5                  10                  15      

Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
            100                 105         


<210> 120
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3309).
      
      

<400> 120
tcctactcca tggagcactt ccgctggggc aagccggtgg gatccggtgg aggctccggt 60
accttagtcg ccgtctcctc agagcccaaa tctgccgaca aaactcacgc ctgcccaccg 120
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa    777

<210> 121
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3309).
      
      

<400> 121
Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Ser Gly
 1               5                  10                  15      
Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro Lys Ser Ala
            20                  25                  30          
Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Pro Gly Lys
            


<210> 122
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3309).
      

<400> 122
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactccatgg agcacttccg ctggggcaag ccggtgggat ccggtggagg ctccggtacc 120
ttagtcgccg tctcctcaga gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc 180
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 240
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 300
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 360
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 420
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 480
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 540
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 600
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 660
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 720
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 780
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       834

<210> 123
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3309).

<400> 123
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val
            20                  25                  30          
Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro
        35                  40                  45              
Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu
    50                  55                  60                  
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
65                  70                  75                  80  
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                85                  90                  95      
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            100                 105                 110         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        115                 120                 125             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    130                 135                 140                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
145                 150                 155                 160 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                165                 170                 175     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            180                 185                 190         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        195                 200                 205             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    210                 215                 220                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
225                 230                 235                 240 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                245                 250                 255     

Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            260                 265                 270         
Ser Leu Ser Pro Gly Lys
        275             


<210> 124
<211> 24
<212> DNA
<213> Homo sapiens

<400> 124
aaaaaaaaaa aaaaaaaaaa aaaa                                        24

<210> 125
<211> 11969
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3309).

<400> 125
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactccatgg agcacttccg 1680
ctggggcaag ccggtgggat ccggtggagg ctccggtacc ttagtcgccg tctcctcaga 1740
gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc ccagcacctg aactcctggg 1800
gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac 1860
ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa 1920
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta 1980
caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg 2040
caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat 2100
ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga 2160
tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga 2220
catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc 2280
cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag 2340
gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta 2400
cacgcagaag agcctctccc tgtctccggg taaatgaggg cccgtttaaa cagatccaga 2460
catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg 2520
ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa 2580
acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga 2640
ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg atccggctgc 2700
ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc 2760
acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcaggcgtc agcgggtgtt 2820
ggcgggtgtc ggggcgcagc catgaggtcg actctagagg atcgatgccc cgccccggac 2880
gaactaaacc tgactacgac atctctgccc cttcttcgcg gggcagtgca tgtaatccct 2940
tcagttggtt ggtacaactt gccaactggg ccctgttcca catgtgacac ggggggggac 3000
caaacacaaa ggggttctct gactgtagtt gacatcctta taaatggatg tgcacatttg 3060
ccaacactga gtggctttca tcctggagca gactttgcag tctgtggact gcaacacaac 3120
attgccttta tgtgtaactc ttggctgaag ctcttacacc aatgctgggg gacatgtacc 3180
tcccaggggc ccaggaagac tacgggaggc tacaccaacg tcaatcagag gggcctgtgt 3240
agctaccgat aagcggaccc tcaagagggc attagcaata gtgtttataa ggcccccttg 3300
ttaaccctaa acgggtagca tatgcttccc gggtagtagt atatactatc cagactaacc 3360
ctaattcaat agcatatgtt acccaacggg aagcatatgc tatcgaatta gggttagtaa 3420
aagggtccta aggaacagcg atatctccca ccccatgagc tgtcacggtt ttatttacat 3480
ggggtcagga ttccacgagg gtagtgaacc attttagtca caagggcagt ggctgaagat 3540
caaggagcgg gcagtgaact ctcctgaatc ttcgcctgct tcttcattct ccttcgttta 3600
gctaatagaa taactgctga gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa 3660
ggtttcaggt gacgccccca gaataaaatt tggacggggg gttcagtggt ggcattgtgc 3720
tatgacacca atataaccct cacaaacccc ttgggcaata aatactagtg taggaatgaa 3780
acattctgaa tatctttaac aatagaaatc catggggtgg ggacaagccg taaagactgg 3840
atgtccatct cacacgaatt tatggctatg ggcaacacat aatcctagtg caatatgata 3900
ctggggttat taagatgtgt cccaggcagg gaccaagaca ggtgaaccat gttgttacac 3960
tctatttgta acaaggggaa agagagtgga cgccgacagc agcggactcc actggttgtc 4020
tctaacaccc ccgaaaatta aacggggctc cacgccaatg gggcccataa acaaagacaa 4080
gtggccactc ttttttttga aattgtggag tgggggcacg cgtcagcccc cacacgccgc 4140
cctgcggttt tggactgtaa aataagggtg taataacttg gctgattgta accccgctaa 4200
ccactgcggt caaaccactt gcccacaaaa ccactaatgg caccccgggg aatacctgca 4260
taagtaggtg ggcgggccaa gataggggcg cgattgctgc gatctggagg acaaattaca 4320
cacacttgcg cctgagcgcc aagcacaggg ttgttggtcc tcatattcac gaggtcgctg 4380
agagcacggt gggctaatgt tgccatgggt agcatatact acccaaatat ctggatagca 4440
tatgctatcc taatctatat ctgggtagca taggctatcc taatctatat ctgggtagca 4500
tatgctatcc taatctatat ctgggtagta tatgctatcc taatttatat ctgggtagca 4560
taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta 4620
tatgctatcc taatctgtat ccgggtagca tatgctatcc taatagagat tagggtagta 4680
tatgctatcc taatttatat ctgggtagca tatactaccc aaatatctgg atagcatatg 4740
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagcatagg 4800
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg 4860
ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg 4920
ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg gtagcatatg 4980
ctatcctcat gcatatacag tcagcatatg atacccagta gtagagtggg agtgctatcc 5040
tttgcatatg ccgccacctc ccaagggggc gtgaattttc gctgcttgtc cttttcctgc 5100
tggttgctcc cattcttagg tgaatttaag gaggccaggc taaagccgtc gcatgtctga 5160
ttgctcacca ggtaaatgtc gctaatgttt tccaacgcga gaaggtgttg agcgcggagc 5220
tgagtgacgt gacaacatgg gtatgcccaa ttgccccatg ttgggaggac gaaaatggtg 5280
acaagacaga tggccagaaa tacaccaaca gcacgcatga tgtctactgg ggatttattc 5340
tttagtgcgg gggaatacac ggcttttaat acgattgagg gcgtctccta acaagttaca 5400
tcactcctgc ccttcctcac cctcatctcc atcacctcct tcatctccgt catctccgtc 5460
atcaccctcc gcggcagccc cttccaccat aggtggaaac cagggaggca aatctactcc 5520
atcgtcaaag ctgcacacag tcaccctgat attgcaggta ggagcgggct ttgtcataac 5580
aaggtcctta atcgcatcct tcaaaacctc agcaaatata tgagtttgta aaaagaccat 5640
gaaataacag acaatggact cccttagcgg gccaggttgt gggccgggtc caggggccat 5700
tccaaagggg agacgactca atggtgtaag acgacattgt ggaatagcaa gggcagttcc 5760
tcgccttagg ttgtaaaggg aggtcttact acctccatat acgaacacac cggcgaccca 5820
agttccttcg tcggtagtcc tttctacgtg actcctagcc aggagagctc ttaaaccttc 5880
tgcaatgttc tcaaatttcg ggttggaacc tccttgacca cgatgctttt ccaaaccacc 5940
ctcctttttt gcgccctgcc tccatcaccc tgaccccggg gtccagtgct tgggccttct 6000
cctgggtcat ctgcggggcc ctgctctatc gctcccgggg gcacgtcagg ctcaccatct 6060
gggccacctt cttggtggta ttcaaaataa tcggcttccc ctacagggtg gaaaaatggc 6120
cttctacctg gagggggcct gcgcggtgga gacccggatg atgatgactg actactggga 6180
ctcctgggcc tcttttctcc acgtccacga cctctccccc tggctctttc acgacttccc 6240
cccctggctc tttcacgtcc tctaccccgg cggcctccac tacctcctcg accccggcct 6300
ccactacctc ctcgaccccg gcctccactg cctcctcgac cccggcctcc acctcctgct 6360
cctgcccctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgctcct 6420
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6480
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6540
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6600
cctgctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc ccctcctgcc 6660
cctcctcctg ctcctgcccc tcctgctcct gcccctcctg cccctcctgc ccctcctgct 6720
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6780
cctcctgccc ctcctcctgc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6840
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6900
cctgcccctc ctgcccctcc tgcccctcct cctgctcctg cccctcctcc tgctcctgcc 6960
cctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 7020
gcccctcctg ctcctgcccc tcccgctcct gctcctgctc ctgttccacc gtgggtccct 7080
ttgcagccaa tgcaacttgg acgtttttgg ggtctccgga caccatctct atgtcttggc 7140
cctgatcctg agccgcccgg ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc 7200
cgtcctcgtc catggttatc accccctctt ctttgaggtc cactgccgcc ggagccttct 7260
ggtccagatg tgtctccctt ctctcctagg ccatttccag gtcctgtacc tggcccctcg 7320
tcagacatga ttcacactaa aagagatcaa tagacatctt tattagacga cgctcagtga 7380
atacagggag tgcagactcc tgccccctcc aacagccccc ccaccctcat ccccttcatg 7440
gtcgctgtca gacagatcca ggtctgaaaa ttccccatcc tccgaaccat cctcgtcctc 7500
atcaccaatt actcgcagcc cggaaaactc ccgctgaaca tcctcaagat ttgcgtcctg 7560
agcctcaagc caggcctcaa attcctcgtc cccctttttg ctggacggta gggatgggga 7620
ttctcgggac ccctcctctt cctcttcaag gtcaccagac agagatgcta ctggggcaac 7680
ggaagaaaag ctgggtgcgg cctgtgagga tcagcttatc gatgataagc tgtcaaacat 7740
gagaattctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg 7800
ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct 7860
atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 7920
taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc 7980
cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg 8040
aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc 8100
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact 8160
tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc 8220
ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag 8280
catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat 8340
aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt 8400
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa 8460
gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc 8520
aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg 8580
gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt 8640
gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca 8700
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat 8760
gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca 8820
gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg 8880
atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg 8940
ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt 9000
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg 9060
ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata 9120
ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca 9180
ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag 9240
tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc 9300
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga 9360
tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg 9420
tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac 9480
gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg 9540
tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg 9600
ttcctggcct tttgctggcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac 9660
agcatggcct gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg 9720
aaggccatcc agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccccg 9780
agatgcgccg cgtgcggctg ctggagatgg cggacgcgat ggatatgttc tgccaagggt 9840
tggtttgcgc attcacagtt ctccgcaaga attgattggc tccaattctt ggagtggtga 9900
atccgttagc gaggtgccgc cctgcttcat ccccgtggcc cgttgctcgc gtttgctggc 9960
ggtgtccccg gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc 10020
cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag 10080
gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga 10140
cccgcttaac agcgtcaaca gcgtgccgca gatcccgggg ggcaatgaga tatgaaaaag 10200
cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc 10260
gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg 10320
cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga tcgttatgtt 10380
tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat tggggaattc 10440
agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg 10500
cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct 10560
gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa 10620
tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta tcactggcaa 10680
actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt 10740
tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg ctccaacaat 10800
gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc gatgttcggg 10860
gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc ttgtatggag 10920
cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc gcggctccgg 10980
gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga cggcaatttc 11040
gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg agccgggact 11100
gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa 11160
gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cggatcggga gatgggggag 11220
gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga cggcaataaa 11280
aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg gttcggtccc 11340
agggctggca ctctgtcgat accccaccga gaccccattg gggccaatac gcccgcgttt 11400
cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc gcagccaacg 11460
tcggggcggc aggccctgcc atagccactg gccccgtggg ttagggacgg ggtcccccat 11520
ggggaatggt ttatggttcg tgggggttat tattttgggc gttgcgtggg gtcaggtcca 11580
cgactggact gagcagacag acccatggtt tttggatggc ctgggcatgg accgcatgta 11640
ctggcgcgac acgaacaccg ggcgtctgtg gctgccaaac acccccgacc cccaaaaacc 11700
accgcgcgga tttctggcgt gccaagctag tcgaccaatt ctcatgtttg acagcttatc 11760
atcgcagatc cgggcaacgt tgttgccatt gctgcaggcg cagaactggt aggtatggaa 11820
gatctataca ttgaatcaat attggcaatt agccatatta gtcattggtt atatagcata 11880
aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta 11940
tattggctca tgtccaatat gaccgccat                                   11969



<210> 126
<211> 720
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3167).

<400> 126
tcctactcca tggagcactt ccgctggggc aagccggtgg gaggaggcgg atcctgccca 60
ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 120
aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 180
cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 240
aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 300
gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 360
ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 420
gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc 480
ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg 540
gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac 600
agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg 660
atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tctgggtaaa 720


<210> 127
<211> 240
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3167).

<400> 127
Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Gly Gly
 1               5                  10                  15      
Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
            20                  25                  30          
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
        35                  40                  45              
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
    50                  55                  60                  
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
65                  70                  75                  80  
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
                85                  90                  95      
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
            100                 105                 110         
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
        115                 120                 125             
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
    130                 135                 140                 
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
145                 150                 155                 160 
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
                165                 170                 175     
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
            180                 185                 190         
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
        195                 200                 205             
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
    210                 215                 220                 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
225                 230                 235                 240 


<210> 128
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3167).

<400> 128
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactccatgg agcacttccg ctggggcaag ccggtgggag gaggcggatc ctgcccaccg 120
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctct gggtaaa    777

<210> 129
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3167).

<400> 129
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val
            20                  25                  30          
Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Leu Gly Lys
            


<210> 130
<211> 11912
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3167).

<400> 130
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactccatgg agcacttccg 1680
ctggggcaag ccggtgggag gaggcggatc ctgcccaccg tgcccagcac ctgaactcct 1740
ggggggaccg tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg 1800
gacccctgag gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt 1860
caactggtac gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca 1920
gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa 1980
tggcaaggag tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac 2040
catctccaaa gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg 2100
ggatgagctg accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag 2160
cgacatcgcc gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc 2220
tcccgtgctg gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag 2280
caggtggcag caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca 2340
ctacacgcag aagagcctct ccctgtctct gggtaaatga gggcccgttt aaacagatcc 2400
agacatgata agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa 2460
atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa 2520
taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg 2580
ggaggttttt taaagcaagt aaaacctcta caaatgtggt atggctgatt atgatccggc 2640
tgcctcgcgc gtttcggtga tgacggtgaa aacctctgac acatgcagct cccggagacg 2700
gtcacagctt gtctgtaagc ggatgccggg agcagacaag cccgtcaggc gtcagcgggt 2760
gttggcgggt gtcggggcgc agccatgagg tcgactctag aggatcgatg ccccgccccg 2820
gacgaactaa acctgactac gacatctctg ccccttcttc gcggggcagt gcatgtaatc 2880
ccttcagttg gttggtacaa cttgccaact gggccctgtt ccacatgtga cacggggggg 2940
gaccaaacac aaaggggttc tctgactgta gttgacatcc ttataaatgg atgtgcacat 3000
ttgccaacac tgagtggctt tcatcctgga gcagactttg cagtctgtgg actgcaacac 3060
aacattgcct ttatgtgtaa ctcttggctg aagctcttac accaatgctg ggggacatgt 3120
acctcccagg ggcccaggaa gactacggga ggctacacca acgtcaatca gaggggcctg 3180
tgtagctacc gataagcgga ccctcaagag ggcattagca atagtgttta taaggccccc 3240
ttgttaaccc taaacgggta gcatatgctt cccgggtagt agtatatact atccagacta 3300
accctaattc aatagcatat gttacccaac gggaagcata tgctatcgaa ttagggttag 3360
taaaagggtc ctaaggaaca gcgatatctc ccaccccatg agctgtcacg gttttattta 3420
catggggtca ggattccacg agggtagtga accattttag tcacaagggc agtggctgaa 3480
gatcaaggag cgggcagtga actctcctga atcttcgcct gcttcttcat tctccttcgt 3540
ttagctaata gaataactgc tgagttgtga acagtaaggt gtatgtgagg tgctcgaaaa 3600
caaggtttca ggtgacgccc ccagaataaa atttggacgg ggggttcagt ggtggcattg 3660
tgctatgaca ccaatataac cctcacaaac cccttgggca ataaatacta gtgtaggaat 3720
gaaacattct gaatatcttt aacaatagaa atccatgggg tggggacaag ccgtaaagac 3780
tggatgtcca tctcacacga atttatggct atgggcaaca cataatccta gtgcaatatg 3840
atactggggt tattaagatg tgtcccaggc agggaccaag acaggtgaac catgttgtta 3900
cactctattt gtaacaaggg gaaagagagt ggacgccgac agcagcggac tccactggtt 3960
gtctctaaca cccccgaaaa ttaaacgggg ctccacgcca atggggccca taaacaaaga 4020
caagtggcca ctcttttttt tgaaattgtg gagtgggggc acgcgtcagc ccccacacgc 4080
cgccctgcgg ttttggactg taaaataagg gtgtaataac ttggctgatt gtaaccccgc 4140
taaccactgc ggtcaaacca cttgcccaca aaaccactaa tggcaccccg gggaatacct 4200
gcataagtag gtgggcgggc caagataggg gcgcgattgc tgcgatctgg aggacaaatt 4260
acacacactt gcgcctgagc gccaagcaca gggttgttgg tcctcatatt cacgaggtcg 4320
ctgagagcac ggtgggctaa tgttgccatg ggtagcatat actacccaaa tatctggata 4380
gcatatgcta tcctaatcta tatctgggta gcataggcta tcctaatcta tatctgggta 4440
gcatatgcta tcctaatcta tatctgggta gtatatgcta tcctaattta tatctgggta 4500
gcataggcta tcctaatcta tatctgggta gcatatgcta tcctaatcta tatctgggta 4560
gtatatgcta tcctaatctg tatccgggta gcatatgcta tcctaataga gattagggta 4620
gtatatgcta tcctaattta tatctgggta gcatatacta cccaaatatc tggatagcat 4680
atgctatcct aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagcat 4740
aggctatcct aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagtat 4800
atgctatcct aatttatatc tgggtagcat aggctatcct aatctatatc tgggtagcat 4860
atgctatcct aatctatatc tgggtagtat atgctatcct aatctgtatc cgggtagcat 4920
atgctatcct catgcatata cagtcagcat atgataccca gtagtagagt gggagtgcta 4980
tcctttgcat atgccgccac ctcccaaggg ggcgtgaatt ttcgctgctt gtccttttcc 5040
tgctggttgc tcccattctt aggtgaattt aaggaggcca ggctaaagcc gtcgcatgtc 5100
tgattgctca ccaggtaaat gtcgctaatg ttttccaacg cgagaaggtg ttgagcgcgg 5160
agctgagtga cgtgacaaca tgggtatgcc caattgcccc atgttgggag gacgaaaatg 5220
gtgacaagac agatggccag aaatacacca acagcacgca tgatgtctac tggggattta 5280
ttctttagtg cgggggaata cacggctttt aatacgattg agggcgtctc ctaacaagtt 5340
acatcactcc tgcccttcct caccctcatc tccatcacct ccttcatctc cgtcatctcc 5400
gtcatcaccc tccgcggcag ccccttccac cataggtgga aaccagggag gcaaatctac 5460
tccatcgtca aagctgcaca cagtcaccct gatattgcag gtaggagcgg gctttgtcat 5520
aacaaggtcc ttaatcgcat ccttcaaaac ctcagcaaat atatgagttt gtaaaaagac 5580
catgaaataa cagacaatgg actcccttag cgggccaggt tgtgggccgg gtccaggggc 5640
cattccaaag gggagacgac tcaatggtgt aagacgacat tgtggaatag caagggcagt 5700
tcctcgcctt aggttgtaaa gggaggtctt actacctcca tatacgaaca caccggcgac 5760
ccaagttcct tcgtcggtag tcctttctac gtgactccta gccaggagag ctcttaaacc 5820
ttctgcaatg ttctcaaatt tcgggttgga acctccttga ccacgatgct tttccaaacc 5880
accctccttt tttgcgccct gcctccatca ccctgacccc ggggtccagt gcttgggcct 5940
tctcctgggt catctgcggg gccctgctct atcgctcccg ggggcacgtc aggctcacca 6000
tctgggccac cttcttggtg gtattcaaaa taatcggctt cccctacagg gtggaaaaat 6060
ggccttctac ctggaggggg cctgcgcggt ggagacccgg atgatgatga ctgactactg 6120
ggactcctgg gcctcttttc tccacgtcca cgacctctcc ccctggctct ttcacgactt 6180
ccccccctgg ctctttcacg tcctctaccc cggcggcctc cactacctcc tcgaccccgg 6240
cctccactac ctcctcgacc ccggcctcca ctgcctcctc gaccccggcc tccacctcct 6300
gctcctgccc ctcctgctcc tgcccctcct cctgctcctg cccctcctgc ccctcctgct 6360
cctgcccctc ctgcccctcc tgctcctgcc cctcctgccc ctcctgctcc tgcccctcct 6420
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctgcccct 6480
cctgctcctg cccctcctgc ccctcctgct cctgcccctc ctgcccctcc tgctcctgcc 6540
cctcctgctc ctgcccctcc tgctcctgcc cctcctgctc ctgcccctcc tgcccctcct 6600
gcccctcctc ctgctcctgc ccctcctgct cctgcccctc ctgcccctcc tgcccctcct 6660
gctcctgccc ctcctcctgc tcctgcccct cctgcccctc ctgcccctcc tcctgctcct 6720
gcccctcctg cccctcctcc tgctcctgcc cctcctcctg ctcctgcccc tcctgcccct 6780
cctgcccctc ctcctgctcc tgcccctcct gcccctcctc ctgctcctgc ccctcctcct 6840
gctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 6900
gcccctcctg cccctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6960
cctgcccctc ctgctcctgc ccctcccgct cctgctcctg ctcctgttcc accgtgggtc 7020
cctttgcagc caatgcaact tggacgtttt tggggtctcc ggacaccatc tctatgtctt 7080
ggccctgatc ctgagccgcc cggggctcct ggtcttccgc ctcctcgtcc tcgtcctctt 7140
ccccgtcctc gtccatggtt atcaccccct cttctttgag gtccactgcc gccggagcct 7200
tctggtccag atgtgtctcc cttctctcct aggccatttc caggtcctgt acctggcccc 7260
tcgtcagaca tgattcacac taaaagagat caatagacat ctttattaga cgacgctcag 7320
tgaatacagg gagtgcagac tcctgccccc tccaacagcc cccccaccct catccccttc 7380
atggtcgctg tcagacagat ccaggtctga aaattcccca tcctccgaac catcctcgtc 7440
ctcatcacca attactcgca gcccggaaaa ctcccgctga acatcctcaa gatttgcgtc 7500
ctgagcctca agccaggcct caaattcctc gtcccccttt ttgctggacg gtagggatgg 7560
ggattctcgg gacccctcct cttcctcttc aaggtcacca gacagagatg ctactggggc 7620
aacggaagaa aagctgggtg cggcctgtga ggatcagctt atcgatgata agctgtcaaa 7680
catgagaatt cttgaagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc 7740
atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc 7800
cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc 7860
tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc 7920
gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg 7980
gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat 8040
ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc 8100
acttttaaag ttctgctatg tggcgcggta ttatcccgtg ttgacgccgg gcaagagcaa 8160
ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa 8220
aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt 8280
gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct 8340
tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat 8400
gaagccatac caaacgacga gcgtgacacc acgatgcctg cagcaatggc aacaacgttg 8460
cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg 8520
atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt 8580
attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg 8640
ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg 8700
gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg 8760
tcagaccaag tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa 8820
aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt 8880
tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt 8940
tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt 9000
ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag 9060
ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa gaactctgta 9120
gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat 9180
aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg 9240
ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg 9300
agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac 9360
aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga 9420
aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt 9480
ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta 9540
cggttcctgg ccttttgctg gccttgaagc tgtccctgat ggtcgtcatc tacctgcctg 9600
gacagcatgg cctgcaacgc gggcatcccg atgccgccgg aagcgagaag aatcataatg 9660
gggaaggcca tccagcctcg cgtcgcgaac gccagcaaga cgtagcccag cgcgtcggcc 9720
ccgagatgcg ccgcgtgcgg ctgctggaga tggcggacgc gatggatatg ttctgccaag 9780
ggttggtttg cgcattcaca gttctccgca agaattgatt ggctccaatt cttggagtgg 9840
tgaatccgtt agcgaggtgc cgccctgctt catccccgtg gcccgttgct cgcgtttgct 9900
ggcggtgtcc ccggaagaaa tatatttgca tgtctttagt tctatgatga cacaaacccc 9960
gcccagcgtc ttgtcattgg cgaattcgaa cacgcagatg cagtcggggc ggcgcggtcc 10020
gaggtccact tcgcatatta aggtgacgcg tgtggcctcg aacaccgagc gaccctgcag 10080
cgacccgctt aacagcgtca acagcgtgcc gcagatcccg gggggcaatg agatatgaaa 10140
aagcctgaac tcaccgcgac gtctgtcgag aagtttctga tcgaaaagtt cgacagcgtc 10200
tccgacctga tgcagctctc ggagggcgaa gaatctcgtg ctttcagctt cgatgtagga 10260
gggcgtggat atgtcctgcg ggtaaatagc tgcgccgatg gtttctacaa agatcgttat 10320
gtttatcggc actttgcatc ggccgcgctc ccgattccgg aagtgcttga cattggggaa 10380
ttcagcgaga gcctgaccta ttgcatctcc cgccgtgcac agggtgtcac gttgcaagac 10440
ctgcctgaaa ccgaactgcc cgctgttctg cagccggtcg cggaggccat ggatgcgatc 10500
gctgcggccg atcttagcca gacgagcggg ttcggcccat tcggaccgca aggaatcggt 10560
caatacacta catggcgtga tttcatatgc gcgattgctg atccccatgt gtatcactgg 10620
caaactgtga tggacgacac cgtcagtgcg tccgtcgcgc aggctctcga tgagctgatg 10680
ctttgggccg aggactgccc cgaagtccgg cacctcgtgc acgcggattt cggctccaac 10740
aatgtcctga cggacaatgg ccgcataaca gcggtcattg actggagcga ggcgatgttc 10800
ggggattccc aatacgaggt cgccaacatc ttcttctgga ggccgtggtt ggcttgtatg 10860
gagcagcaga cgcgctactt cgagcggagg catccggagc ttgcaggatc gccgcggctc 10920
cgggcgtata tgctccgcat tggtcttgac caactctatc agagcttggt tgacggcaat 10980
ttcgatgatg cagcttgggc gcagggtcga tgcgacgcaa tcgtccgatc cggagccggg 11040
actgtcgggc gtacacaaat cgcccgcaga agcgcggccg tctggaccga tggctgtgta 11100
gaagtactcg ccgatagtgg aaaccgacgc cccagcactc gtccggatcg ggagatgggg 11160
gaggctaact gaaacacgga aggagacaat accggaagga acccgcgcta tgacggcaat 11220
aaaaagacag aataaaacgc acgggtgttg ggtcgtttgt tcataaacgc ggggttcggt 11280
cccagggctg gcactctgtc gataccccac cgagacccca ttggggccaa tacgcccgcg 11340
tttcttcctt ttccccaccc caccccccaa gttcgggtga aggcccaggg ctcgcagcca 11400
acgtcggggc ggcaggccct gccatagcca ctggccccgt gggttaggga cggggtcccc 11460
catggggaat ggtttatggt tcgtgggggt tattattttg ggcgttgcgt ggggtcaggt 11520
ccacgactgg actgagcaga cagacccatg gtttttggat ggcctgggca tggaccgcat 11580
gtactggcgc gacacgaaca ccgggcgtct gtggctgcca aacacccccg acccccaaaa 11640
accaccgcgc ggatttctgg cgtgccaagc tagtcgacca attctcatgt ttgacagctt 11700
atcatcgcag atccgggcaa cgttgttgcc attgctgcag gcgcagaact ggtaggtatg 11760
gaagatctat acattgaatc aatattggca attagccata ttagtcattg gttatatagc 11820
ataaatcaat attggctatt ggccattgca tacgttgtat ctatatcata atatgtacat 11880
ttatattggc tcatgtccaa tatgaccgcc at                               11912



<210> 131
<211> 735
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3168).

<400> 131
tcctactcca tggagcactt ccgctggggc aagccggtgg ggggcggagg aagcggcgga 60
ggcggatcct gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc 120
ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg 180
gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg 240
gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg 300
gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag 360
gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag 420
ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag 480
gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag 540
agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc 600
tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc 660
ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc 720
ctgtctctgg gtaaa                                                  735

<210> 132
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3168).

<400> 132
Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Gly Gly
 1               5                  10                  15      
Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu
            20                  25                  30          
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
        35                  40                  45              
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
    50                  55                  60                  
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
65                  70                  75                  80  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
                85                  90                  95      
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
            100                 105                 110         

Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
        115                 120                 125             
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
    130                 135                 140                 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
145                 150                 155                 160 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
                165                 170                 175     
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
            180                 185                 190         
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
        195                 200                 205             
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
    210                 215                 220                 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
225                 230                 235                 240 
Leu Ser Leu Gly Lys
                245 


<210> 133
<211> 792
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3168).

<400> 133
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactccatgg agcacttccg ctggggcaag ccggtggggg gcggaggaag cggcggaggc 120
ggatcctgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc 180
cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 240
gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 300
gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 360
agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc 420
tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 480
cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc 540
agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 600
aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 660
ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 720
tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 780
tctctgggta aa                                                     792

<210> 134
<211> 264
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3168).

<400> 134
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val
            20                  25                  30          
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala
        35                  40                  45              
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
    50                  55                  60                  
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
65                  70                  75                  80  
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
                85                  90                  95      
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
            100                 105                 110         
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
        115                 120                 125             
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
    130                 135                 140                 
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
145                 150                 155                 160 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
                165                 170                 175     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
            180                 185                 190         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
        195                 200                 205             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
    210                 215                 220                 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
225                 230                 235                 240 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                245                 250                 255     
Ser Leu Ser Leu Ser Leu Gly Lys
            260                 


<210> 135
<211> 11927
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3168).
      
      

<400> 135
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactccatgg agcacttccg 1680
ctggggcaag ccggtggggg gcggaggaag cggcggaggc ggatcctgcc caccgtgccc 1740
agcacctgaa ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac 1800
cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga 1860
ccctgaggtc aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa 1920
gccgcgggag gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca 1980
ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc 2040
ccccatcgag aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac 2100
cctgccccca tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa 2160
aggcttctat cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa 2220
ctacaagacc acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct 2280
caccgtggac aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga 2340
ggctctgcac aaccactaca cgcagaagag cctctccctg tctctgggta aatgagggcc 2400
cgtttaaaca gatccagaca tgataagata cattgatgag tttggacaaa ccacaactag 2460
aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac 2520
cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt 2580
tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtatggc 2640
tgattatgat ccggctgcct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg 2700
cagctcccgg agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt 2760
caggcgtcag cgggtgttgg cgggtgtcgg ggcgcagcca tgaggtcgac tctagaggat 2820
cgatgccccg ccccggacga actaaacctg actacgacat ctctgcccct tcttcgcggg 2880
gcagtgcatg taatcccttc agttggttgg tacaacttgc caactgggcc ctgttccaca 2940
tgtgacacgg ggggggacca aacacaaagg ggttctctga ctgtagttga catccttata 3000
aatggatgtg cacatttgcc aacactgagt ggctttcatc ctggagcaga ctttgcagtc 3060
tgtggactgc aacacaacat tgcctttatg tgtaactctt ggctgaagct cttacaccaa 3120
tgctggggga catgtacctc ccaggggccc aggaagacta cgggaggcta caccaacgtc 3180
aatcagaggg gcctgtgtag ctaccgataa gcggaccctc aagagggcat tagcaatagt 3240
gtttataagg cccccttgtt aaccctaaac gggtagcata tgcttcccgg gtagtagtat 3300
atactatcca gactaaccct aattcaatag catatgttac ccaacgggaa gcatatgcta 3360
tcgaattagg gttagtaaaa gggtcctaag gaacagcgat atctcccacc ccatgagctg 3420
tcacggtttt atttacatgg ggtcaggatt ccacgagggt agtgaaccat tttagtcaca 3480
agggcagtgg ctgaagatca aggagcgggc agtgaactct cctgaatctt cgcctgcttc 3540
ttcattctcc ttcgtttagc taatagaata actgctgagt tgtgaacagt aaggtgtatg 3600
tgaggtgctc gaaaacaagg tttcaggtga cgcccccaga ataaaatttg gacggggggt 3660
tcagtggtgg cattgtgcta tgacaccaat ataaccctca caaacccctt gggcaataaa 3720
tactagtgta ggaatgaaac attctgaata tctttaacaa tagaaatcca tggggtgggg 3780
acaagccgta aagactggat gtccatctca cacgaattta tggctatggg caacacataa 3840
tcctagtgca atatgatact ggggttatta agatgtgtcc caggcaggga ccaagacagg 3900
tgaaccatgt tgttacactc tatttgtaac aaggggaaag agagtggacg ccgacagcag 3960
cggactccac tggttgtctc taacaccccc gaaaattaaa cggggctcca cgccaatggg 4020
gcccataaac aaagacaagt ggccactctt ttttttgaaa ttgtggagtg ggggcacgcg 4080
tcagccccca cacgccgccc tgcggttttg gactgtaaaa taagggtgta ataacttggc 4140
tgattgtaac cccgctaacc actgcggtca aaccacttgc ccacaaaacc actaatggca 4200
ccccggggaa tacctgcata agtaggtggg cgggccaaga taggggcgcg attgctgcga 4260
tctggaggac aaattacaca cacttgcgcc tgagcgccaa gcacagggtt gttggtcctc 4320
atattcacga ggtcgctgag agcacggtgg gctaatgttg ccatgggtag catatactac 4380
ccaaatatct ggatagcata tgctatccta atctatatct gggtagcata ggctatccta 4440
atctatatct gggtagcata tgctatccta atctatatct gggtagtata tgctatccta 4500
atttatatct gggtagcata ggctatccta atctatatct gggtagcata tgctatccta 4560
atctatatct gggtagtata tgctatccta atctgtatcc gggtagcata tgctatccta 4620
atagagatta gggtagtata tgctatccta atttatatct gggtagcata tactacccaa 4680
atatctggat agcatatgct atcctaatct atatctgggt agcatatgct atcctaatct 4740
atatctgggt agcataggct atcctaatct atatctgggt agcatatgct atcctaatct 4800
atatctgggt agtatatgct atcctaattt atatctgggt agcataggct atcctaatct 4860
atatctgggt agcatatgct atcctaatct atatctgggt agtatatgct atcctaatct 4920
gtatccgggt agcatatgct atcctcatgc atatacagtc agcatatgat acccagtagt 4980
agagtgggag tgctatcctt tgcatatgcc gccacctccc aagggggcgt gaattttcgc 5040
tgcttgtcct tttcctgctg gttgctccca ttcttaggtg aatttaagga ggccaggcta 5100
aagccgtcgc atgtctgatt gctcaccagg taaatgtcgc taatgttttc caacgcgaga 5160
aggtgttgag cgcggagctg agtgacgtga caacatgggt atgcccaatt gccccatgtt 5220
gggaggacga aaatggtgac aagacagatg gccagaaata caccaacagc acgcatgatg 5280
tctactgggg atttattctt tagtgcgggg gaatacacgg cttttaatac gattgagggc 5340
gtctcctaac aagttacatc actcctgccc ttcctcaccc tcatctccat cacctccttc 5400
atctccgtca tctccgtcat caccctccgc ggcagcccct tccaccatag gtggaaacca 5460
gggaggcaaa tctactccat cgtcaaagct gcacacagtc accctgatat tgcaggtagg 5520
agcgggcttt gtcataacaa ggtccttaat cgcatccttc aaaacctcag caaatatatg 5580
agtttgtaaa aagaccatga aataacagac aatggactcc cttagcgggc caggttgtgg 5640
gccgggtcca ggggccattc caaaggggag acgactcaat ggtgtaagac gacattgtgg 5700
aatagcaagg gcagttcctc gccttaggtt gtaaagggag gtcttactac ctccatatac 5760
gaacacaccg gcgacccaag ttccttcgtc ggtagtcctt tctacgtgac tcctagccag 5820
gagagctctt aaaccttctg caatgttctc aaatttcggg ttggaacctc cttgaccacg 5880
atgcttttcc aaaccaccct ccttttttgc gccctgcctc catcaccctg accccggggt 5940
ccagtgcttg ggccttctcc tgggtcatct gcggggccct gctctatcgc tcccgggggc 6000
acgtcaggct caccatctgg gccaccttct tggtggtatt caaaataatc ggcttcccct 6060
acagggtgga aaaatggcct tctacctgga gggggcctgc gcggtggaga cccggatgat 6120
gatgactgac tactgggact cctgggcctc ttttctccac gtccacgacc tctccccctg 6180
gctctttcac gacttccccc cctggctctt tcacgtcctc taccccggcg gcctccacta 6240
cctcctcgac cccggcctcc actacctcct cgaccccggc ctccactgcc tcctcgaccc 6300
cggcctccac ctcctgctcc tgcccctcct gctcctgccc ctcctcctgc tcctgcccct 6360
cctgcccctc ctgctcctgc ccctcctgcc cctcctgctc ctgcccctcc tgcccctcct 6420
gctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctgcccctcc tcctgctcct 6480
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6540
cctcctgctc ctgcccctcc tgctcctgcc cctcctgctc ctgcccctcc tgctcctgcc 6600
cctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctgctcctgc ccctcctgcc 6660
cctcctgccc ctcctgctcc tgcccctcct cctgctcctg cccctcctgc ccctcctgcc 6720
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 6780
gcccctcctg cccctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctcctgct 6840
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6900
cctcctcctg ctcctgcccc tcctgcccct cctgcccctc ctgcccctcc tcctgctcct 6960
gcccctcctc ctgctcctgc ccctcctgct cctgcccctc ccgctcctgc tcctgctcct 7020
gttccaccgt gggtcccttt gcagccaatg caacttggac gtttttgggg tctccggaca 7080
ccatctctat gtcttggccc tgatcctgag ccgcccgggg ctcctggtct tccgcctcct 7140
cgtcctcgtc ctcttccccg tcctcgtcca tggttatcac cccctcttct ttgaggtcca 7200
ctgccgccgg agccttctgg tccagatgtg tctcccttct ctcctaggcc atttccaggt 7260
cctgtacctg gcccctcgtc agacatgatt cacactaaaa gagatcaata gacatcttta 7320
ttagacgacg ctcagtgaat acagggagtg cagactcctg ccccctccaa cagccccccc 7380
accctcatcc ccttcatggt cgctgtcaga cagatccagg tctgaaaatt ccccatcctc 7440
cgaaccatcc tcgtcctcat caccaattac tcgcagcccg gaaaactccc gctgaacatc 7500
ctcaagattt gcgtcctgag cctcaagcca ggcctcaaat tcctcgtccc cctttttgct 7560
ggacggtagg gatggggatt ctcgggaccc ctcctcttcc tcttcaaggt caccagacag 7620
agatgctact ggggcaacgg aagaaaagct gggtgcggcc tgtgaggatc agcttatcga 7680
tgataagctg tcaaacatga gaattcttga agacgaaagg gcctcgtgat acgcctattt 7740
ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga 7800
aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc 7860
atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt 7920
caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct 7980
cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt 8040
tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt 8100
tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtgttgac 8160
gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac 8220
tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct 8280
gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg 8340
aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg 8400
gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgcagca 8460
atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa 8520
caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt 8580
ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc 8640
attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg 8700
agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt 8760
aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt 8820
catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc 8880
ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct 8940
tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta 9000
ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc 9060
ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac 9120
ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct 9180
gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat 9240
aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg 9300
acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa 9360
gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg 9420
gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga 9480
cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc 9540
aacgcggcct ttttacggtt cctggccttt tgctggcctt gaagctgtcc ctgatggtcg 9600
tcatctacct gcctggacag catggcctgc aacgcgggca tcccgatgcc gccggaagcg 9660
agaagaatca taatggggaa ggccatccag cctcgcgtcg cgaacgccag caagacgtag 9720
cccagcgcgt cggccccgag atgcgccgcg tgcggctgct ggagatggcg gacgcgatgg 9780
atatgttctg ccaagggttg gtttgcgcat tcacagttct ccgcaagaat tgattggctc 9840
caattcttgg agtggtgaat ccgttagcga ggtgccgccc tgcttcatcc ccgtggcccg 9900
ttgctcgcgt ttgctggcgg tgtccccgga agaaatatat ttgcatgtct ttagttctat 9960
gatgacacaa accccgccca gcgtcttgtc attggcgaat tcgaacacgc agatgcagtc 10020
ggggcggcgc ggtccgaggt ccacttcgca tattaaggtg acgcgtgtgg cctcgaacac 10080
cgagcgaccc tgcagcgacc cgcttaacag cgtcaacagc gtgccgcaga tcccgggggg 10140
caatgagata tgaaaaagcc tgaactcacc gcgacgtctg tcgagaagtt tctgatcgaa 10200
aagttcgaca gcgtctccga cctgatgcag ctctcggagg gcgaagaatc tcgtgctttc 10260
agcttcgatg taggagggcg tggatatgtc ctgcgggtaa atagctgcgc cgatggtttc 10320
tacaaagatc gttatgttta tcggcacttt gcatcggccg cgctcccgat tccggaagtg 10380
cttgacattg gggaattcag cgagagcctg acctattgca tctcccgccg tgcacagggt 10440
gtcacgttgc aagacctgcc tgaaaccgaa ctgcccgctg ttctgcagcc ggtcgcggag 10500
gccatggatg cgatcgctgc ggccgatctt agccagacga gcgggttcgg cccattcgga 10560
ccgcaaggaa tcggtcaata cactacatgg cgtgatttca tatgcgcgat tgctgatccc 10620
catgtgtatc actggcaaac tgtgatggac gacaccgtca gtgcgtccgt cgcgcaggct 10680
ctcgatgagc tgatgctttg ggccgaggac tgccccgaag tccggcacct cgtgcacgcg 10740
gatttcggct ccaacaatgt cctgacggac aatggccgca taacagcggt cattgactgg 10800
agcgaggcga tgttcgggga ttcccaatac gaggtcgcca acatcttctt ctggaggccg 10860
tggttggctt gtatggagca gcagacgcgc tacttcgagc ggaggcatcc ggagcttgca 10920
ggatcgccgc ggctccgggc gtatatgctc cgcattggtc ttgaccaact ctatcagagc 10980
ttggttgacg gcaatttcga tgatgcagct tgggcgcagg gtcgatgcga cgcaatcgtc 11040
cgatccggag ccgggactgt cgggcgtaca caaatcgccc gcagaagcgc ggccgtctgg 11100
accgatggct gtgtagaagt actcgccgat agtggaaacc gacgccccag cactcgtccg 11160
gatcgggaga tgggggaggc taactgaaac acggaaggag acaataccgg aaggaacccg 11220
cgctatgacg gcaataaaaa gacagaataa aacgcacggg tgttgggtcg tttgttcata 11280
aacgcggggt tcggtcccag ggctggcact ctgtcgatac cccaccgaga ccccattggg 11340
gccaatacgc ccgcgtttct tccttttccc caccccaccc cccaagttcg ggtgaaggcc 11400
cagggctcgc agccaacgtc ggggcggcag gccctgccat agccactggc cccgtgggtt 11460
agggacgggg tcccccatgg ggaatggttt atggttcgtg ggggttatta ttttgggcgt 11520
tgcgtggggt caggtccacg actggactga gcagacagac ccatggtttt tggatggcct 11580
gggcatggac cgcatgtact ggcgcgacac gaacaccggg cgtctgtggc tgccaaacac 11640
ccccgacccc caaaaaccac cgcgcggatt tctggcgtgc caagctagtc gaccaattct 11700
catgtttgac agcttatcat cgcagatccg ggcaacgttg ttgccattgc tgcaggcgca 11760
gaactggtag gtatggaaga tctatacatt gaatcaatat tggcaattag ccatattagt 11820
cattggttat atagcataaa tcaatattgg ctattggcca ttgcatacgt tgtatctata 11880
tcataatatg tacatttata ttggctcatg tccaatatga ccgccat               11927



<210> 136
<211> 750
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3169).
      
      

<400> 136
tcctactcca tggagcactt ccgctggggc aagccggtgg ggggcggagg aagcggcgga 60
ggcgggagcg gcggcggagg atcctgccca ccgtgcccag cacctgaact cctgggggga 120
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 180
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 240
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 300
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 360
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 420
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 480
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 540
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 600
ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg 660
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 720
cagaagagcc tctccctgtc tctgggtaaa                                  750

<210> 137
<211> 250
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3169).
      

<400> 137
Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Gly Gly
 1               5                  10                  15      
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys
            20                  25                  30          
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        35                  40                  45              
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    50                  55                  60                  
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
65                  70                  75                  80  
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                85                  90                  95      
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            100                 105                 110         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        115                 120                 125             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    130                 135                 140                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
145                 150                 155                 160 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                165                 170                 175     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            180                 185                 190         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        195                 200                 205             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    210                 215                 220                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
225                 230                 235                 240 
Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
                245                 250 


<210> 138
<211> 807
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3169).
      

<400> 138
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactccatgg agcacttccg ctggggcaag ccggtggggg gcggaggaag cggcggaggc 120
gggagcggcg gcggaggatc ctgcccaccg tgcccagcac ctgaactcct ggggggaccg 180
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 240
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 300
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 360
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 420
tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 480
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 540
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 600
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 660
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 720
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 780
aagagcctct ccctgtctct gggtaaa                                     807

<210> 139
<211> 269
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3169).
      

<400> 139
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val
            20                  25                  30          
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys
        35                  40                  45              
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
    50                  55                  60                  
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
65                  70                  75                  80  
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                85                  90                  95      
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
            100                 105                 110         
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
        115                 120                 125             
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
    130                 135                 140                 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
145                 150                 155                 160 
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
                165                 170                 175     
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
            180                 185                 190         
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
        195                 200                 205             
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
    210                 215                 220                 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
225                 230                 235                 240 
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
                245                 250                 255     
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
            260                 265                 


<210> 140
<211> 11942
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3169).
      

<400> 140
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactccatgg agcacttccg 1680
ctggggcaag ccggtggggg gcggaggaag cggcggaggc gggagcggcg gcggaggatc 1740
ctgcccaccg tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc 1800
aaaacccaag gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga 1860
cgtgagccac gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca 1920
taatgccaag acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt 1980
cctcaccgtc ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa 2040
caaagccctc ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga 2100
accacaggtg tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct 2160
gacctgcctg gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg 2220
gcagccggag aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt 2280
cctctacagc aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg 2340
ctccgtgatg catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctct 2400
gggtaaatga gggcccgttt aaacagatcc agacatgata agatacattg atgagtttgg 2460
acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat 2520
tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca 2580
ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaagcaagt aaaacctcta 2640
caaatgtggt atggctgatt atgatccggc tgcctcgcgc gtttcggtga tgacggtgaa 2700
aacctctgac acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg 2760
agcagacaag cccgtcaggc gtcagcgggt gttggcgggt gtcggggcgc agccatgagg 2820
tcgactctag aggatcgatg ccccgccccg gacgaactaa acctgactac gacatctctg 2880
ccccttcttc gcggggcagt gcatgtaatc ccttcagttg gttggtacaa cttgccaact 2940
gggccctgtt ccacatgtga cacggggggg gaccaaacac aaaggggttc tctgactgta 3000
gttgacatcc ttataaatgg atgtgcacat ttgccaacac tgagtggctt tcatcctgga 3060
gcagactttg cagtctgtgg actgcaacac aacattgcct ttatgtgtaa ctcttggctg 3120
aagctcttac accaatgctg ggggacatgt acctcccagg ggcccaggaa gactacggga 3180
ggctacacca acgtcaatca gaggggcctg tgtagctacc gataagcgga ccctcaagag 3240
ggcattagca atagtgttta taaggccccc ttgttaaccc taaacgggta gcatatgctt 3300
cccgggtagt agtatatact atccagacta accctaattc aatagcatat gttacccaac 3360
gggaagcata tgctatcgaa ttagggttag taaaagggtc ctaaggaaca gcgatatctc 3420
ccaccccatg agctgtcacg gttttattta catggggtca ggattccacg agggtagtga 3480
accattttag tcacaagggc agtggctgaa gatcaaggag cgggcagtga actctcctga 3540
atcttcgcct gcttcttcat tctccttcgt ttagctaata gaataactgc tgagttgtga 3600
acagtaaggt gtatgtgagg tgctcgaaaa caaggtttca ggtgacgccc ccagaataaa 3660
atttggacgg ggggttcagt ggtggcattg tgctatgaca ccaatataac cctcacaaac 3720
cccttgggca ataaatacta gtgtaggaat gaaacattct gaatatcttt aacaatagaa 3780
atccatgggg tggggacaag ccgtaaagac tggatgtcca tctcacacga atttatggct 3840
atgggcaaca cataatccta gtgcaatatg atactggggt tattaagatg tgtcccaggc 3900
agggaccaag acaggtgaac catgttgtta cactctattt gtaacaaggg gaaagagagt 3960
ggacgccgac agcagcggac tccactggtt gtctctaaca cccccgaaaa ttaaacgggg 4020
ctccacgcca atggggccca taaacaaaga caagtggcca ctcttttttt tgaaattgtg 4080
gagtgggggc acgcgtcagc ccccacacgc cgccctgcgg ttttggactg taaaataagg 4140
gtgtaataac ttggctgatt gtaaccccgc taaccactgc ggtcaaacca cttgcccaca 4200
aaaccactaa tggcaccccg gggaatacct gcataagtag gtgggcgggc caagataggg 4260
gcgcgattgc tgcgatctgg aggacaaatt acacacactt gcgcctgagc gccaagcaca 4320
gggttgttgg tcctcatatt cacgaggtcg ctgagagcac ggtgggctaa tgttgccatg 4380
ggtagcatat actacccaaa tatctggata gcatatgcta tcctaatcta tatctgggta 4440
gcataggcta tcctaatcta tatctgggta gcatatgcta tcctaatcta tatctgggta 4500
gtatatgcta tcctaattta tatctgggta gcataggcta tcctaatcta tatctgggta 4560
gcatatgcta tcctaatcta tatctgggta gtatatgcta tcctaatctg tatccgggta 4620
gcatatgcta tcctaataga gattagggta gtatatgcta tcctaattta tatctgggta 4680
gcatatacta cccaaatatc tggatagcat atgctatcct aatctatatc tgggtagcat 4740
atgctatcct aatctatatc tgggtagcat aggctatcct aatctatatc tgggtagcat 4800
atgctatcct aatctatatc tgggtagtat atgctatcct aatttatatc tgggtagcat 4860
aggctatcct aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagtat 4920
atgctatcct aatctgtatc cgggtagcat atgctatcct catgcatata cagtcagcat 4980
atgataccca gtagtagagt gggagtgcta tcctttgcat atgccgccac ctcccaaggg 5040
ggcgtgaatt ttcgctgctt gtccttttcc tgctggttgc tcccattctt aggtgaattt 5100
aaggaggcca ggctaaagcc gtcgcatgtc tgattgctca ccaggtaaat gtcgctaatg 5160
ttttccaacg cgagaaggtg ttgagcgcgg agctgagtga cgtgacaaca tgggtatgcc 5220
caattgcccc atgttgggag gacgaaaatg gtgacaagac agatggccag aaatacacca 5280
acagcacgca tgatgtctac tggggattta ttctttagtg cgggggaata cacggctttt 5340
aatacgattg agggcgtctc ctaacaagtt acatcactcc tgcccttcct caccctcatc 5400
tccatcacct ccttcatctc cgtcatctcc gtcatcaccc tccgcggcag ccccttccac 5460
cataggtgga aaccagggag gcaaatctac tccatcgtca aagctgcaca cagtcaccct 5520
gatattgcag gtaggagcgg gctttgtcat aacaaggtcc ttaatcgcat ccttcaaaac 5580
ctcagcaaat atatgagttt gtaaaaagac catgaaataa cagacaatgg actcccttag 5640
cgggccaggt tgtgggccgg gtccaggggc cattccaaag gggagacgac tcaatggtgt 5700
aagacgacat tgtggaatag caagggcagt tcctcgcctt aggttgtaaa gggaggtctt 5760
actacctcca tatacgaaca caccggcgac ccaagttcct tcgtcggtag tcctttctac 5820
gtgactccta gccaggagag ctcttaaacc ttctgcaatg ttctcaaatt tcgggttgga 5880
acctccttga ccacgatgct tttccaaacc accctccttt tttgcgccct gcctccatca 5940
ccctgacccc ggggtccagt gcttgggcct tctcctgggt catctgcggg gccctgctct 6000
atcgctcccg ggggcacgtc aggctcacca tctgggccac cttcttggtg gtattcaaaa 6060
taatcggctt cccctacagg gtggaaaaat ggccttctac ctggaggggg cctgcgcggt 6120
ggagacccgg atgatgatga ctgactactg ggactcctgg gcctcttttc tccacgtcca 6180
cgacctctcc ccctggctct ttcacgactt ccccccctgg ctctttcacg tcctctaccc 6240
cggcggcctc cactacctcc tcgaccccgg cctccactac ctcctcgacc ccggcctcca 6300
ctgcctcctc gaccccggcc tccacctcct gctcctgccc ctcctgctcc tgcccctcct 6360
cctgctcctg cccctcctgc ccctcctgct cctgcccctc ctgcccctcc tgctcctgcc 6420
cctcctgccc ctcctgctcc tgcccctcct gcccctcctc ctgctcctgc ccctcctgcc 6480
cctcctcctg ctcctgcccc tcctgcccct cctgctcctg cccctcctgc ccctcctgct 6540
cctgcccctc ctgcccctcc tgctcctgcc cctcctgctc ctgcccctcc tgctcctgcc 6600
cctcctgctc ctgcccctcc tgcccctcct gcccctcctc ctgctcctgc ccctcctgct 6660
cctgcccctc ctgcccctcc tgcccctcct gctcctgccc ctcctcctgc tcctgcccct 6720
cctgcccctc ctgcccctcc tcctgctcct gcccctcctg cccctcctcc tgctcctgcc 6780
cctcctcctg ctcctgcccc tcctgcccct cctgcccctc ctcctgctcc tgcccctcct 6840
gcccctcctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgcccct 6900
cctcctgctc ctgcccctcc tcctgctcct gcccctcctg cccctcctgc ccctcctgcc 6960
cctcctcctg ctcctgcccc tcctcctgct cctgcccctc ctgctcctgc ccctcccgct 7020
cctgctcctg ctcctgttcc accgtgggtc cctttgcagc caatgcaact tggacgtttt 7080
tggggtctcc ggacaccatc tctatgtctt ggccctgatc ctgagccgcc cggggctcct 7140
ggtcttccgc ctcctcgtcc tcgtcctctt ccccgtcctc gtccatggtt atcaccccct 7200
cttctttgag gtccactgcc gccggagcct tctggtccag atgtgtctcc cttctctcct 7260
aggccatttc caggtcctgt acctggcccc tcgtcagaca tgattcacac taaaagagat 7320
caatagacat ctttattaga cgacgctcag tgaatacagg gagtgcagac tcctgccccc 7380
tccaacagcc cccccaccct catccccttc atggtcgctg tcagacagat ccaggtctga 7440
aaattcccca tcctccgaac catcctcgtc ctcatcacca attactcgca gcccggaaaa 7500
ctcccgctga acatcctcaa gatttgcgtc ctgagcctca agccaggcct caaattcctc 7560
gtcccccttt ttgctggacg gtagggatgg ggattctcgg gacccctcct cttcctcttc 7620
aaggtcacca gacagagatg ctactggggc aacggaagaa aagctgggtg cggcctgtga 7680
ggatcagctt atcgatgata agctgtcaaa catgagaatt cttgaagacg aaagggcctc 7740
gtgatacgcc tatttttata ggttaatgtc atgataataa tggtttctta gacgtcaggt 7800
ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca 7860
aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg 7920
aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc 7980
cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg 8040
ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt 8100
cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta 8160
ttatcccgtg ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat 8220
gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga 8280
gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca 8340
acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact 8400
cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc 8460
acgatgcctg cagcaatggc aacaacgttg cgcaaactat taactggcga actacttact 8520
ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt 8580
ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt 8640
gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt 8700
atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata 8760
ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag 8820
attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat 8880
ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa 8940
aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca 9000
aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt 9060
ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg 9120
tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc 9180
ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga 9240
cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc 9300
agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc 9360
gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca 9420
ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg 9480
tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta 9540
tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttgaagc 9600
tgtccctgat ggtcgtcatc tacctgcctg gacagcatgg cctgcaacgc gggcatcccg 9660
atgccgccgg aagcgagaag aatcataatg gggaaggcca tccagcctcg cgtcgcgaac 9720
gccagcaaga cgtagcccag cgcgtcggcc ccgagatgcg ccgcgtgcgg ctgctggaga 9780
tggcggacgc gatggatatg ttctgccaag ggttggtttg cgcattcaca gttctccgca 9840
agaattgatt ggctccaatt cttggagtgg tgaatccgtt agcgaggtgc cgccctgctt 9900
catccccgtg gcccgttgct cgcgtttgct ggcggtgtcc ccggaagaaa tatatttgca 9960
tgtctttagt tctatgatga cacaaacccc gcccagcgtc ttgtcattgg cgaattcgaa 10020
cacgcagatg cagtcggggc ggcgcggtcc gaggtccact tcgcatatta aggtgacgcg 10080
tgtggcctcg aacaccgagc gaccctgcag cgacccgctt aacagcgtca acagcgtgcc 10140
gcagatcccg gggggcaatg agatatgaaa aagcctgaac tcaccgcgac gtctgtcgag 10200
aagtttctga tcgaaaagtt cgacagcgtc tccgacctga tgcagctctc ggagggcgaa 10260
gaatctcgtg ctttcagctt cgatgtagga gggcgtggat atgtcctgcg ggtaaatagc 10320
tgcgccgatg gtttctacaa agatcgttat gtttatcggc actttgcatc ggccgcgctc 10380
ccgattccgg aagtgcttga cattggggaa ttcagcgaga gcctgaccta ttgcatctcc 10440
cgccgtgcac agggtgtcac gttgcaagac ctgcctgaaa ccgaactgcc cgctgttctg 10500
cagccggtcg cggaggccat ggatgcgatc gctgcggccg atcttagcca gacgagcggg 10560
ttcggcccat tcggaccgca aggaatcggt caatacacta catggcgtga tttcatatgc 10620
gcgattgctg atccccatgt gtatcactgg caaactgtga tggacgacac cgtcagtgcg 10680
tccgtcgcgc aggctctcga tgagctgatg ctttgggccg aggactgccc cgaagtccgg 10740
cacctcgtgc acgcggattt cggctccaac aatgtcctga cggacaatgg ccgcataaca 10800
gcggtcattg actggagcga ggcgatgttc ggggattccc aatacgaggt cgccaacatc 10860
ttcttctgga ggccgtggtt ggcttgtatg gagcagcaga cgcgctactt cgagcggagg 10920
catccggagc ttgcaggatc gccgcggctc cgggcgtata tgctccgcat tggtcttgac 10980
caactctatc agagcttggt tgacggcaat ttcgatgatg cagcttgggc gcagggtcga 11040
tgcgacgcaa tcgtccgatc cggagccggg actgtcgggc gtacacaaat cgcccgcaga 11100
agcgcggccg tctggaccga tggctgtgta gaagtactcg ccgatagtgg aaaccgacgc 11160
cccagcactc gtccggatcg ggagatgggg gaggctaact gaaacacgga aggagacaat 11220
accggaagga acccgcgcta tgacggcaat aaaaagacag aataaaacgc acgggtgttg 11280
ggtcgtttgt tcataaacgc ggggttcggt cccagggctg gcactctgtc gataccccac 11340
cgagacccca ttggggccaa tacgcccgcg tttcttcctt ttccccaccc caccccccaa 11400
gttcgggtga aggcccaggg ctcgcagcca acgtcggggc ggcaggccct gccatagcca 11460
ctggccccgt gggttaggga cggggtcccc catggggaat ggtttatggt tcgtgggggt 11520
tattattttg ggcgttgcgt ggggtcaggt ccacgactgg actgagcaga cagacccatg 11580
gtttttggat ggcctgggca tggaccgcat gtactggcgc gacacgaaca ccgggcgtct 11640
gtggctgcca aacacccccg acccccaaaa accaccgcgc ggatttctgg cgtgccaagc 11700
tagtcgacca attctcatgt ttgacagctt atcatcgcag atccgggcaa cgttgttgcc 11760
attgctgcag gcgcagaact ggtaggtatg gaagatctat acattgaatc aatattggca 11820
attagccata ttagtcattg gttatatagc ataaatcaat attggctatt ggccattgca 11880
tacgttgtat ctatatcata atatgtacat ttatattggc tcatgtccaa tatgaccgcc 11940
at                                                                11942



<210> 141
<211> 765
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3170).
      

<400> 141
tcctactcca tggagcactt ccgctggggc aagccggtgg ggggcggagg aagcggcgga 60
ggcgggagcg gcggcggagg ctccggtggc ggaggatcct gcccaccgtg cccagcacct 120
gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg 180
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag 240
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg 300
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac 360
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc 420
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc 480
ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc 540
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag 600
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg 660
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg 720
cacaaccact acacgcagaa gagcctctcc ctgtctctgg gtaaa                 765

<210> 142
<211> 255
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3170).
      

<400> 142
Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Gly Gly
 1               5                  10                  15      
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
            20                  25                  30          
Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
        35                  40                  45              
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
    50                  55                  60                  
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
65                  70                  75                  80  
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
                85                  90                  95      
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
            100                 105                 110         
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
        115                 120                 125             
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
    130                 135                 140                 
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
145                 150                 155                 160 
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
                165                 170                 175     
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
            180                 185                 190         
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
        195                 200                 205             
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
    210                 215                 220                 
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
225                 230                 235                 240 
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
                245                 250                 255 


<210> 143
<211> 822
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3170).
      

<400> 143
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactccatgg agcacttccg ctggggcaag ccggtggggg gcggaggaag cggcggaggc 120
gggagcggcg gcggaggctc cggtggcgga ggatcctgcc caccgtgccc agcacctgaa 180
ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc 240
tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc 300
aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag 360
gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg 420
ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag 480
aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca 540
tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat 600
cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc 660
acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac 720
aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac 780
aaccactaca cgcagaagag cctctccctg tctctgggta aa                    822

<210> 144
<211> 274
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3170).
      

<400> 144
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val
            20                  25                  30          
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
        35                  40                  45              
Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
    50                  55                  60                  
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
65                  70                  75                  80  
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
                85                  90                  95      
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
            100                 105                 110         
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
        115                 120                 125             
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
    130                 135                 140                 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
145                 150                 155                 160 
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
                165                 170                 175     
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
            180                 185                 190         
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
        195                 200                 205             
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
    210                 215                 220                 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
225                 230                 235                 240 
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
                245                 250                 255     
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu
            260                 265                 270         
Gly Lys
        


<210> 145
<211> 11957
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3170).
      

<400> 145
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactccatgg agcacttccg 1680
ctggggcaag ccggtggggg gcggaggaag cggcggaggc gggagcggcg gcggaggctc 1740
cggtggcgga ggatcctgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt 1800
cttcctcttc cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac 1860
atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga 1920
cggcgtggag gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta 1980
ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa 2040
gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa 2100
agggcagccc cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa 2160
gaaccaggtc agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga 2220
gtgggagagc aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc 2280
cgacggctcc ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg 2340
gaacgtcttc tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag 2400
cctctccctg tctctgggta aatgagggcc cgtttaaaca gatccagaca tgataagata 2460
cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga 2520
aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa 2580
caacaattgc attcatttta tgtttcaggt tcagggggag gtgtgggagg ttttttaaag 2640
caagtaaaac ctctacaaat gtggtatggc tgattatgat ccggctgcct cgcgcgtttc 2700
ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg agacggtcac agcttgtctg 2760
taagcggatg ccgggagcag acaagcccgt caggcgtcag cgggtgttgg cgggtgtcgg 2820
ggcgcagcca tgaggtcgac tctagaggat cgatgccccg ccccggacga actaaacctg 2880
actacgacat ctctgcccct tcttcgcggg gcagtgcatg taatcccttc agttggttgg 2940
tacaacttgc caactgggcc ctgttccaca tgtgacacgg ggggggacca aacacaaagg 3000
ggttctctga ctgtagttga catccttata aatggatgtg cacatttgcc aacactgagt 3060
ggctttcatc ctggagcaga ctttgcagtc tgtggactgc aacacaacat tgcctttatg 3120
tgtaactctt ggctgaagct cttacaccaa tgctggggga catgtacctc ccaggggccc 3180
aggaagacta cgggaggcta caccaacgtc aatcagaggg gcctgtgtag ctaccgataa 3240
gcggaccctc aagagggcat tagcaatagt gtttataagg cccccttgtt aaccctaaac 3300
gggtagcata tgcttcccgg gtagtagtat atactatcca gactaaccct aattcaatag 3360
catatgttac ccaacgggaa gcatatgcta tcgaattagg gttagtaaaa gggtcctaag 3420
gaacagcgat atctcccacc ccatgagctg tcacggtttt atttacatgg ggtcaggatt 3480
ccacgagggt agtgaaccat tttagtcaca agggcagtgg ctgaagatca aggagcgggc 3540
agtgaactct cctgaatctt cgcctgcttc ttcattctcc ttcgtttagc taatagaata 3600
actgctgagt tgtgaacagt aaggtgtatg tgaggtgctc gaaaacaagg tttcaggtga 3660
cgcccccaga ataaaatttg gacggggggt tcagtggtgg cattgtgcta tgacaccaat 3720
ataaccctca caaacccctt gggcaataaa tactagtgta ggaatgaaac attctgaata 3780
tctttaacaa tagaaatcca tggggtgggg acaagccgta aagactggat gtccatctca 3840
cacgaattta tggctatggg caacacataa tcctagtgca atatgatact ggggttatta 3900
agatgtgtcc caggcaggga ccaagacagg tgaaccatgt tgttacactc tatttgtaac 3960
aaggggaaag agagtggacg ccgacagcag cggactccac tggttgtctc taacaccccc 4020
gaaaattaaa cggggctcca cgccaatggg gcccataaac aaagacaagt ggccactctt 4080
ttttttgaaa ttgtggagtg ggggcacgcg tcagccccca cacgccgccc tgcggttttg 4140
gactgtaaaa taagggtgta ataacttggc tgattgtaac cccgctaacc actgcggtca 4200
aaccacttgc ccacaaaacc actaatggca ccccggggaa tacctgcata agtaggtggg 4260
cgggccaaga taggggcgcg attgctgcga tctggaggac aaattacaca cacttgcgcc 4320
tgagcgccaa gcacagggtt gttggtcctc atattcacga ggtcgctgag agcacggtgg 4380
gctaatgttg ccatgggtag catatactac ccaaatatct ggatagcata tgctatccta 4440
atctatatct gggtagcata ggctatccta atctatatct gggtagcata tgctatccta 4500
atctatatct gggtagtata tgctatccta atttatatct gggtagcata ggctatccta 4560
atctatatct gggtagcata tgctatccta atctatatct gggtagtata tgctatccta 4620
atctgtatcc gggtagcata tgctatccta atagagatta gggtagtata tgctatccta 4680
atttatatct gggtagcata tactacccaa atatctggat agcatatgct atcctaatct 4740
atatctgggt agcatatgct atcctaatct atatctgggt agcataggct atcctaatct 4800
atatctgggt agcatatgct atcctaatct atatctgggt agtatatgct atcctaattt 4860
atatctgggt agcataggct atcctaatct atatctgggt agcatatgct atcctaatct 4920
atatctgggt agtatatgct atcctaatct gtatccgggt agcatatgct atcctcatgc 4980
atatacagtc agcatatgat acccagtagt agagtgggag tgctatcctt tgcatatgcc 5040
gccacctccc aagggggcgt gaattttcgc tgcttgtcct tttcctgctg gttgctccca 5100
ttcttaggtg aatttaagga ggccaggcta aagccgtcgc atgtctgatt gctcaccagg 5160
taaatgtcgc taatgttttc caacgcgaga aggtgttgag cgcggagctg agtgacgtga 5220
caacatgggt atgcccaatt gccccatgtt gggaggacga aaatggtgac aagacagatg 5280
gccagaaata caccaacagc acgcatgatg tctactgggg atttattctt tagtgcgggg 5340
gaatacacgg cttttaatac gattgagggc gtctcctaac aagttacatc actcctgccc 5400
ttcctcaccc tcatctccat cacctccttc atctccgtca tctccgtcat caccctccgc 5460
ggcagcccct tccaccatag gtggaaacca gggaggcaaa tctactccat cgtcaaagct 5520
gcacacagtc accctgatat tgcaggtagg agcgggcttt gtcataacaa ggtccttaat 5580
cgcatccttc aaaacctcag caaatatatg agtttgtaaa aagaccatga aataacagac 5640
aatggactcc cttagcgggc caggttgtgg gccgggtcca ggggccattc caaaggggag 5700
acgactcaat ggtgtaagac gacattgtgg aatagcaagg gcagttcctc gccttaggtt 5760
gtaaagggag gtcttactac ctccatatac gaacacaccg gcgacccaag ttccttcgtc 5820
ggtagtcctt tctacgtgac tcctagccag gagagctctt aaaccttctg caatgttctc 5880
aaatttcggg ttggaacctc cttgaccacg atgcttttcc aaaccaccct ccttttttgc 5940
gccctgcctc catcaccctg accccggggt ccagtgcttg ggccttctcc tgggtcatct 6000
gcggggccct gctctatcgc tcccgggggc acgtcaggct caccatctgg gccaccttct 6060
tggtggtatt caaaataatc ggcttcccct acagggtgga aaaatggcct tctacctgga 6120
gggggcctgc gcggtggaga cccggatgat gatgactgac tactgggact cctgggcctc 6180
ttttctccac gtccacgacc tctccccctg gctctttcac gacttccccc cctggctctt 6240
tcacgtcctc taccccggcg gcctccacta cctcctcgac cccggcctcc actacctcct 6300
cgaccccggc ctccactgcc tcctcgaccc cggcctccac ctcctgctcc tgcccctcct 6360
gctcctgccc ctcctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6420
cctcctgctc ctgcccctcc tgcccctcct gctcctgccc ctcctgcccc tcctcctgct 6480
cctgcccctc ctgcccctcc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6540
cctgcccctc ctgctcctgc ccctcctgcc cctcctgctc ctgcccctcc tgctcctgcc 6600
cctcctgctc ctgcccctcc tgctcctgcc cctcctgccc ctcctgcccc tcctcctgct 6660
cctgcccctc ctgctcctgc ccctcctgcc cctcctgccc ctcctgctcc tgcccctcct 6720
cctgctcctg cccctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctgcccct 6780
cctcctgctc ctgcccctcc tcctgctcct gcccctcctg cccctcctgc ccctcctcct 6840
gctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctcctgctcc tgcccctcct 6900
gcccctcctg cccctcctcc tgctcctgcc cctcctcctg ctcctgcccc tcctgcccct 6960
cctgcccctc ctgcccctcc tcctgctcct gcccctcctc ctgctcctgc ccctcctgct 7020
cctgcccctc ccgctcctgc tcctgctcct gttccaccgt gggtcccttt gcagccaatg 7080
caacttggac gtttttgggg tctccggaca ccatctctat gtcttggccc tgatcctgag 7140
ccgcccgggg ctcctggtct tccgcctcct cgtcctcgtc ctcttccccg tcctcgtcca 7200
tggttatcac cccctcttct ttgaggtcca ctgccgccgg agccttctgg tccagatgtg 7260
tctcccttct ctcctaggcc atttccaggt cctgtacctg gcccctcgtc agacatgatt 7320
cacactaaaa gagatcaata gacatcttta ttagacgacg ctcagtgaat acagggagtg 7380
cagactcctg ccccctccaa cagccccccc accctcatcc ccttcatggt cgctgtcaga 7440
cagatccagg tctgaaaatt ccccatcctc cgaaccatcc tcgtcctcat caccaattac 7500
tcgcagcccg gaaaactccc gctgaacatc ctcaagattt gcgtcctgag cctcaagcca 7560
ggcctcaaat tcctcgtccc cctttttgct ggacggtagg gatggggatt ctcgggaccc 7620
ctcctcttcc tcttcaaggt caccagacag agatgctact ggggcaacgg aagaaaagct 7680
gggtgcggcc tgtgaggatc agcttatcga tgataagctg tcaaacatga gaattcttga 7740
agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt 7800
tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt 7860
ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa 7920
taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt 7980
tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat 8040
gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag 8100
atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg 8160
ctatgtggcg cggtattatc ccgtgttgac gccgggcaag agcaactcgg tcgccgcata 8220
cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat 8280
ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc 8340
aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg 8400
ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac 8460
gacgagcgtg acaccacgat gcctgcagca atggcaacaa cgttgcgcaa actattaact 8520
ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa 8580
gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct 8640
ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc 8700
tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga 8760
cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac 8820
tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag 8880
atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg 8940
tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc 9000
tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag 9060
ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc 9120
cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac 9180
ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc 9240
gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt 9300
tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt 9360
gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc 9420
ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt 9480
tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca 9540
ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt 9600
tgctggcctt gaagctgtcc ctgatggtcg tcatctacct gcctggacag catggcctgc 9660
aacgcgggca tcccgatgcc gccggaagcg agaagaatca taatggggaa ggccatccag 9720
cctcgcgtcg cgaacgccag caagacgtag cccagcgcgt cggccccgag atgcgccgcg 9780
tgcggctgct ggagatggcg gacgcgatgg atatgttctg ccaagggttg gtttgcgcat 9840
tcacagttct ccgcaagaat tgattggctc caattcttgg agtggtgaat ccgttagcga 9900
ggtgccgccc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg tgtccccgga 9960
agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca gcgtcttgtc 10020
attggcgaat tcgaacacgc agatgcagtc ggggcggcgc ggtccgaggt ccacttcgca 10080
tattaaggtg acgcgtgtgg cctcgaacac cgagcgaccc tgcagcgacc cgcttaacag 10140
cgtcaacagc gtgccgcaga tcccgggggg caatgagata tgaaaaagcc tgaactcacc 10200
gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 10260
ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc 10320
ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt 10380
gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaattcag cgagagcctg 10440
acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa 10500
ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 10560
agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg 10620
cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac 10680
gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac 10740
tgccccgaag tccggcacct cgtgcacgcg gatttcggct ccaacaatgt cctgacggac 10800
aatggccgca taacagcggt cattgactgg agcgaggcga tgttcgggga ttcccaatac 10860
gaggtcgcca acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc 10920
tacttcgagc ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc gtatatgctc 10980
cgcattggtc ttgaccaact ctatcagagc ttggttgacg gcaatttcga tgatgcagct 11040
tgggcgcagg gtcgatgcga cgcaatcgtc cgatccggag ccgggactgt cgggcgtaca 11100
caaatcgccc gcagaagcgc ggccgtctgg accgatggct gtgtagaagt actcgccgat 11160
agtggaaacc gacgccccag cactcgtccg gatcgggaga tgggggaggc taactgaaac 11220
acggaaggag acaataccgg aaggaacccg cgctatgacg gcaataaaaa gacagaataa 11280
aacgcacggg tgttgggtcg tttgttcata aacgcggggt tcggtcccag ggctggcact 11340
ctgtcgatac cccaccgaga ccccattggg gccaatacgc ccgcgtttct tccttttccc 11400
caccccaccc cccaagttcg ggtgaaggcc cagggctcgc agccaacgtc ggggcggcag 11460
gccctgccat agccactggc cccgtgggtt agggacgggg tcccccatgg ggaatggttt 11520
atggttcgtg ggggttatta ttttgggcgt tgcgtggggt caggtccacg actggactga 11580
gcagacagac ccatggtttt tggatggcct gggcatggac cgcatgtact ggcgcgacac 11640
gaacaccggg cgtctgtggc tgccaaacac ccccgacccc caaaaaccac cgcgcggatt 11700
tctggcgtgc caagctagtc gaccaattct catgtttgac agcttatcat cgcagatccg 11760
ggcaacgttg ttgccattgc tgcaggcgca gaactggtag gtatggaaga tctatacatt 11820
gaatcaatat tggcaattag ccatattagt cattggttat atagcataaa tcaatattgg 11880
ctattggcca ttgcatacgt tgtatctata tcataatatg tacatttata ttggctcatg 11940
tccaatatga ccgccat                                                11957



<210> 146
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3159).
      

<400> 146
tcctactcct gcgagcactt ccgctggtgc aagccggtgg gatccggtgg aggctccggt 60
accttagtcg ccgtctcctc agagcccaaa tctgccgaca aaactcacgc ctgcccaccg 120
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa    777

<210> 147
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3159).
      

<400> 147
Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly Ser Gly
 1               5                  10                  15      

Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro Lys Ser Ala
            20                  25                  30          
Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Pro Gly Lys
            


<210> 148
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3159).
      

<400> 148
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactcctgcg agcacttccg ctggtgcaag ccggtgggat ccggtggagg ctccggtacc 120
ttagtcgccg tctcctcaga gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc 180
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 240
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 300
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 360
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 420
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 480
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 540
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 600
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 660
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 720
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 780
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       834

<210> 149
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3159).

<400> 149

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val
            20                  25                  30          
Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro
        35                  40                  45              
Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu
    50                  55                  60                  
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
65                  70                  75                  80  
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                85                  90                  95      
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            100                 105                 110         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        115                 120                 125             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    130                 135                 140                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
145                 150                 155                 160 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                165                 170                 175     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            180                 185                 190         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        195                 200                 205             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    210                 215                 220                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
225                 230                 235                 240 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                245                 250                 255     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            260                 265                 270         
Ser Leu Ser Pro Gly Lys
        275             


<210> 150
<211> 11969
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3159).

<400> 150
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactcctgcg agcacttccg 1680
ctggtgcaag ccggtgggat ccggtggagg ctccggtacc ttagtcgccg tctcctcaga 1740
gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc ccagcacctg aactcctggg 1800
gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac 1860
ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa 1920
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta 1980
caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg 2040
caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat 2100
ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga 2160
tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga 2220
catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc 2280
cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag 2340
gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta 2400
cacgcagaag agcctctccc tgtctccggg taaatgaggg cccgtttaaa cagatccaga 2460
catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg 2520
ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa 2580
acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga 2640
ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg atccggctgc 2700
ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc 2760
acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcaggcgtc agcgggtgtt 2820
ggcgggtgtc ggggcgcagc catgaggtcg actctagagg atcgatgccc cgccccggac 2880
gaactaaacc tgactacgac atctctgccc cttcttcgcg gggcagtgca tgtaatccct 2940
tcagttggtt ggtacaactt gccaactggg ccctgttcca catgtgacac ggggggggac 3000
caaacacaaa ggggttctct gactgtagtt gacatcctta taaatggatg tgcacatttg 3060
ccaacactga gtggctttca tcctggagca gactttgcag tctgtggact gcaacacaac 3120
attgccttta tgtgtaactc ttggctgaag ctcttacacc aatgctgggg gacatgtacc 3180
tcccaggggc ccaggaagac tacgggaggc tacaccaacg tcaatcagag gggcctgtgt 3240
agctaccgat aagcggaccc tcaagagggc attagcaata gtgtttataa ggcccccttg 3300
ttaaccctaa acgggtagca tatgcttccc gggtagtagt atatactatc cagactaacc 3360
ctaattcaat agcatatgtt acccaacggg aagcatatgc tatcgaatta gggttagtaa 3420
aagggtccta aggaacagcg atatctccca ccccatgagc tgtcacggtt ttatttacat 3480
ggggtcagga ttccacgagg gtagtgaacc attttagtca caagggcagt ggctgaagat 3540
caaggagcgg gcagtgaact ctcctgaatc ttcgcctgct tcttcattct ccttcgttta 3600
gctaatagaa taactgctga gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa 3660
ggtttcaggt gacgccccca gaataaaatt tggacggggg gttcagtggt ggcattgtgc 3720
tatgacacca atataaccct cacaaacccc ttgggcaata aatactagtg taggaatgaa 3780
acattctgaa tatctttaac aatagaaatc catggggtgg ggacaagccg taaagactgg 3840
atgtccatct cacacgaatt tatggctatg ggcaacacat aatcctagtg caatatgata 3900
ctggggttat taagatgtgt cccaggcagg gaccaagaca ggtgaaccat gttgttacac 3960
tctatttgta acaaggggaa agagagtgga cgccgacagc agcggactcc actggttgtc 4020
tctaacaccc ccgaaaatta aacggggctc cacgccaatg gggcccataa acaaagacaa 4080
gtggccactc ttttttttga aattgtggag tgggggcacg cgtcagcccc cacacgccgc 4140
cctgcggttt tggactgtaa aataagggtg taataacttg gctgattgta accccgctaa 4200
ccactgcggt caaaccactt gcccacaaaa ccactaatgg caccccgggg aatacctgca 4260
taagtaggtg ggcgggccaa gataggggcg cgattgctgc gatctggagg acaaattaca 4320
cacacttgcg cctgagcgcc aagcacaggg ttgttggtcc tcatattcac gaggtcgctg 4380
agagcacggt gggctaatgt tgccatgggt agcatatact acccaaatat ctggatagca 4440
tatgctatcc taatctatat ctgggtagca taggctatcc taatctatat ctgggtagca 4500
tatgctatcc taatctatat ctgggtagta tatgctatcc taatttatat ctgggtagca 4560
taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta 4620
tatgctatcc taatctgtat ccgggtagca tatgctatcc taatagagat tagggtagta 4680
tatgctatcc taatttatat ctgggtagca tatactaccc aaatatctgg atagcatatg 4740
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagcatagg 4800
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg 4860
ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg 4920
ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg gtagcatatg 4980
ctatcctcat gcatatacag tcagcatatg atacccagta gtagagtggg agtgctatcc 5040
tttgcatatg ccgccacctc ccaagggggc gtgaattttc gctgcttgtc cttttcctgc 5100
tggttgctcc cattcttagg tgaatttaag gaggccaggc taaagccgtc gcatgtctga 5160
ttgctcacca ggtaaatgtc gctaatgttt tccaacgcga gaaggtgttg agcgcggagc 5220
tgagtgacgt gacaacatgg gtatgcccaa ttgccccatg ttgggaggac gaaaatggtg 5280
acaagacaga tggccagaaa tacaccaaca gcacgcatga tgtctactgg ggatttattc 5340
tttagtgcgg gggaatacac ggcttttaat acgattgagg gcgtctccta acaagttaca 5400
tcactcctgc ccttcctcac cctcatctcc atcacctcct tcatctccgt catctccgtc 5460
atcaccctcc gcggcagccc cttccaccat aggtggaaac cagggaggca aatctactcc 5520
atcgtcaaag ctgcacacag tcaccctgat attgcaggta ggagcgggct ttgtcataac 5580
aaggtcctta atcgcatcct tcaaaacctc agcaaatata tgagtttgta aaaagaccat 5640
gaaataacag acaatggact cccttagcgg gccaggttgt gggccgggtc caggggccat 5700
tccaaagggg agacgactca atggtgtaag acgacattgt ggaatagcaa gggcagttcc 5760
tcgccttagg ttgtaaaggg aggtcttact acctccatat acgaacacac cggcgaccca 5820
agttccttcg tcggtagtcc tttctacgtg actcctagcc aggagagctc ttaaaccttc 5880
tgcaatgttc tcaaatttcg ggttggaacc tccttgacca cgatgctttt ccaaaccacc 5940
ctcctttttt gcgccctgcc tccatcaccc tgaccccggg gtccagtgct tgggccttct 6000
cctgggtcat ctgcggggcc ctgctctatc gctcccgggg gcacgtcagg ctcaccatct 6060
gggccacctt cttggtggta ttcaaaataa tcggcttccc ctacagggtg gaaaaatggc 6120
cttctacctg gagggggcct gcgcggtgga gacccggatg atgatgactg actactggga 6180
ctcctgggcc tcttttctcc acgtccacga cctctccccc tggctctttc acgacttccc 6240
cccctggctc tttcacgtcc tctaccccgg cggcctccac tacctcctcg accccggcct 6300
ccactacctc ctcgaccccg gcctccactg cctcctcgac cccggcctcc acctcctgct 6360
cctgcccctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgctcct 6420
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6480
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6540
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6600
cctgctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc ccctcctgcc 6660
cctcctcctg ctcctgcccc tcctgctcct gcccctcctg cccctcctgc ccctcctgct 6720
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6780
cctcctgccc ctcctcctgc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6840
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6900
cctgcccctc ctgcccctcc tgcccctcct cctgctcctg cccctcctcc tgctcctgcc 6960
cctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 7020
gcccctcctg ctcctgcccc tcccgctcct gctcctgctc ctgttccacc gtgggtccct 7080
ttgcagccaa tgcaacttgg acgtttttgg ggtctccgga caccatctct atgtcttggc 7140
cctgatcctg agccgcccgg ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc 7200
cgtcctcgtc catggttatc accccctctt ctttgaggtc cactgccgcc ggagccttct 7260
ggtccagatg tgtctccctt ctctcctagg ccatttccag gtcctgtacc tggcccctcg 7320
tcagacatga ttcacactaa aagagatcaa tagacatctt tattagacga cgctcagtga 7380
atacagggag tgcagactcc tgccccctcc aacagccccc ccaccctcat ccccttcatg 7440
gtcgctgtca gacagatcca ggtctgaaaa ttccccatcc tccgaaccat cctcgtcctc 7500
atcaccaatt actcgcagcc cggaaaactc ccgctgaaca tcctcaagat ttgcgtcctg 7560
agcctcaagc caggcctcaa attcctcgtc cccctttttg ctggacggta gggatgggga 7620
ttctcgggac ccctcctctt cctcttcaag gtcaccagac agagatgcta ctggggcaac 7680
ggaagaaaag ctgggtgcgg cctgtgagga tcagcttatc gatgataagc tgtcaaacat 7740
gagaattctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg 7800
ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct 7860
atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 7920
taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc 7980
cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg 8040
aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc 8100
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact 8160
tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc 8220
ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag 8280
catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat 8340
aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt 8400
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa 8460
gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc 8520
aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg 8580
gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt 8640
gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca 8700
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat 8760
gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca 8820
gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg 8880
atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg 8940
ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt 9000
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg 9060
ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata 9120
ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca 9180
ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag 9240
tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc 9300
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga 9360
tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg 9420
tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac 9480
gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg 9540
tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg 9600
ttcctggcct tttgctggcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac 9660
agcatggcct gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg 9720
aaggccatcc agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccccg 9780
agatgcgccg cgtgcggctg ctggagatgg cggacgcgat ggatatgttc tgccaagggt 9840
tggtttgcgc attcacagtt ctccgcaaga attgattggc tccaattctt ggagtggtga 9900
atccgttagc gaggtgccgc cctgcttcat ccccgtggcc cgttgctcgc gtttgctggc 9960
ggtgtccccg gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc 10020
cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag 10080
gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga 10140
cccgcttaac agcgtcaaca gcgtgccgca gatcccgggg ggcaatgaga tatgaaaaag 10200
cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc 10260
gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg 10320
cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga tcgttatgtt 10380
tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat tggggaattc 10440
agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg 10500
cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct 10560
gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa 10620
tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta tcactggcaa 10680
actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt 10740
tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg ctccaacaat 10800
gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc gatgttcggg 10860
gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc ttgtatggag 10920
cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc gcggctccgg 10980
gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga cggcaatttc 11040
gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg agccgggact 11100
gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa 11160
gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cggatcggga gatgggggag 11220
gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga cggcaataaa 11280
aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg gttcggtccc 11340
agggctggca ctctgtcgat accccaccga gaccccattg gggccaatac gcccgcgttt 11400
cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc gcagccaacg 11460
tcggggcggc aggccctgcc atagccactg gccccgtggg ttagggacgg ggtcccccat 11520
ggggaatggt ttatggttcg tgggggttat tattttgggc gttgcgtggg gtcaggtcca 11580
cgactggact gagcagacag acccatggtt tttggatggc ctgggcatgg accgcatgta 11640
ctggcgcgac acgaacaccg ggcgtctgtg gctgccaaac acccccgacc cccaaaaacc 11700
accgcgcgga tttctggcgt gccaagctag tcgaccaatt ctcatgtttg acagcttatc 11760
atcgcagatc cgggcaacgt tgttgccatt gctgcaggcg cagaactggt aggtatggaa 11820
gatctataca ttgaatcaat attggcaatt agccatatta gtcattggtt atatagcata 11880
aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta 11940
tattggctca tgtccaatat gaccgccat                                   11969



<210> 151
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3652).

<400> 151
tcctactcct gcgagcactt ccgctggtgc aagccggtgg gatccggtgg aggctccggt 60
accttagtca ccgtctcctc agagtccaaa tatggtcccc catgcccacc atgcccggcg 120
cctgaggccg ccgggggacc atcagtcttc ctgttccccc caaaacccaa ggacactctc 180
atgatctccc ggacccctga ggtcacgtgc gtggtggtgg acgtgagcca ggaagacccc 240
gaggtccagt tcaactggta cgtggatggc gtggaggtgc ataatgccaa gacaaagccg 300
cgggaggagc agttcaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag 360
gactggctga acggcaagga gtacaagtgc aaggtctcca acaaaggcct cccgtcctcc 420
atcgagaaaa ccatctccaa agccaaaggg cagcctcgag agccacaggt gtacaccctg 480
cccccatccc aggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc 540
ttctacccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac 600
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caggctaacc 660
gtggacaaga gcaggtggca ggaggggaat gtcttctcat gctccgtgat gcatgaggct 720
ctgcacaacc actacacaca gaaaagcttg tccctgtctc tgggtaaa              768

<210> 152
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3652).

<400> 152
Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly Ser Gly
 1               5                  10                  15      
Gly Gly Ser Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys Tyr Gly
            20                  25                  30          
Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser
        35                  40                  45              
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    50                  55                  60                  
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro
65                  70                  75                  80  
Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                85                  90                  95      
Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val
            100                 105                 110         
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        115                 120                 125             
Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr
    130                 135                 140                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
145                 150                 155                 160 
Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
                165                 170                 175     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            180                 185                 190         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        195                 200                 205             
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser
    210                 215                 220                 
Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
225                 230                 235                 240 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
                245                 250                 255     


<210> 153
<211> 825
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3652).

<400> 153
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactcctgcg agcacttccg ctggtgcaag ccggtgggat ccggtggagg ctccggtacc 120
ttagtcaccg tctcctcaga gtccaaatat ggtcccccat gcccaccatg cccggcgcct 180
gaggccgccg ggggaccatc agtcttcctg ttccccccaa aacccaagga cactctcatg 240
atctcccgga cccctgaggt cacgtgcgtg gtggtggacg tgagccagga agaccccgag 300
gtccagttca actggtacgt ggatggcgtg gaggtgcata atgccaagac aaagccgcgg 360
gaggagcagt tcaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac 420
tggctgaacg gcaaggagta caagtgcaag gtctccaaca aaggcctccc gtcctccatc 480
gagaaaacca tctccaaagc caaagggcag cctcgagagc cacaggtgta caccctgccc 540
ccatcccagg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc 600
taccccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag 660
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcag gctaaccgtg 720
gacaagagca ggtggcagga ggggaatgtc ttctcatgct ccgtgatgca tgaggctctg 780
cacaaccact acacacagaa aagcttgtcc ctgtctctgg gtaaa                 825

<210> 154
<211> 275
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3652).

<400> 154
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val
            20                  25                  30          
Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Thr Val Ser Ser Glu Ser
        35                  40                  45              
Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly
    50                  55                  60                  
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
65                  70                  75                  80  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln
                85                  90                  95      
Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val
            100                 105                 110         
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr
        115                 120                 125             
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
    130                 135                 140                 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile
145                 150                 155                 160 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
                165                 170                 175     
Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser
            180                 185                 190         
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        195                 200                 205             
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    210                 215                 220                 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val
225                 230                 235                 240 
Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met
                245                 250                 255     
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            260                 265                 270         
Leu Gly Lys
        275 


<210> 155
<211> 11960
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3652).

<400> 155
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactcctgcg agcacttccg 1680
ctggtgcaag ccggtgggat ccggtggagg ctccggtacc ttagtcaccg tctcctcaga 1740
gtccaaatat ggtcccccat gcccaccatg cccggcgcct gaggccgccg ggggaccatc 1800
agtcttcctg ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt 1860
cacgtgcgtg gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt 1920
ggatggcgtg gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac 1980
gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta 2040
caagtgcaag gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc 2100
caaagggcag cctcgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac 2160
caagaaccag gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt 2220
ggagtgggag agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga 2280
ctccgacggc tccttcttcc tctacagcag gctaaccgtg gacaagagca ggtggcagga 2340
ggggaatgtc ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa 2400
aagcttgtcc ctgtctctgg gtaaatgagg gcccgtttaa acagatccag acatgataag 2460
atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg 2520
tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa 2580
caacaacaat tgcattcatt ttatgtttca ggttcagggg gaggtgtggg aggtttttta 2640
aagcaagtaa aacctctaca aatgtggtat ggctgattat gatccggctg cctcgcgcgt 2700
ttcggtgatg acggtgaaaa cctctgacac atgcagctcc cggagacggt cacagcttgt 2760
ctgtaagcgg atgccgggag cagacaagcc cgtcaggcgt cagcgggtgt tggcgggtgt 2820
cggggcgcag ccatgaggtc gactctagag gatcgatgcc ccgccccgga cgaactaaac 2880
ctgactacga catctctgcc ccttcttcgc ggggcagtgc atgtaatccc ttcagttggt 2940
tggtacaact tgccaactgg gccctgttcc acatgtgaca cgggggggga ccaaacacaa 3000
aggggttctc tgactgtagt tgacatcctt ataaatggat gtgcacattt gccaacactg 3060
agtggctttc atcctggagc agactttgca gtctgtggac tgcaacacaa cattgccttt 3120
atgtgtaact cttggctgaa gctcttacac caatgctggg ggacatgtac ctcccagggg 3180
cccaggaaga ctacgggagg ctacaccaac gtcaatcaga ggggcctgtg tagctaccga 3240
taagcggacc ctcaagaggg cattagcaat agtgtttata aggccccctt gttaacccta 3300
aacgggtagc atatgcttcc cgggtagtag tatatactat ccagactaac cctaattcaa 3360
tagcatatgt tacccaacgg gaagcatatg ctatcgaatt agggttagta aaagggtcct 3420
aaggaacagc gatatctccc accccatgag ctgtcacggt tttatttaca tggggtcagg 3480
attccacgag ggtagtgaac cattttagtc acaagggcag tggctgaaga tcaaggagcg 3540
ggcagtgaac tctcctgaat cttcgcctgc ttcttcattc tccttcgttt agctaataga 3600
ataactgctg agttgtgaac agtaaggtgt atgtgaggtg ctcgaaaaca aggtttcagg 3660
tgacgccccc agaataaaat ttggacgggg ggttcagtgg tggcattgtg ctatgacacc 3720
aatataaccc tcacaaaccc cttgggcaat aaatactagt gtaggaatga aacattctga 3780
atatctttaa caatagaaat ccatggggtg gggacaagcc gtaaagactg gatgtccatc 3840
tcacacgaat ttatggctat gggcaacaca taatcctagt gcaatatgat actggggtta 3900
ttaagatgtg tcccaggcag ggaccaagac aggtgaacca tgttgttaca ctctatttgt 3960
aacaagggga aagagagtgg acgccgacag cagcggactc cactggttgt ctctaacacc 4020
cccgaaaatt aaacggggct ccacgccaat ggggcccata aacaaagaca agtggccact 4080
cttttttttg aaattgtgga gtgggggcac gcgtcagccc ccacacgccg ccctgcggtt 4140
ttggactgta aaataagggt gtaataactt ggctgattgt aaccccgcta accactgcgg 4200
tcaaaccact tgcccacaaa accactaatg gcaccccggg gaatacctgc ataagtaggt 4260
gggcgggcca agataggggc gcgattgctg cgatctggag gacaaattac acacacttgc 4320
gcctgagcgc caagcacagg gttgttggtc ctcatattca cgaggtcgct gagagcacgg 4380
tgggctaatg ttgccatggg tagcatatac tacccaaata tctggatagc atatgctatc 4440
ctaatctata tctgggtagc ataggctatc ctaatctata tctgggtagc atatgctatc 4500
ctaatctata tctgggtagt atatgctatc ctaatttata tctgggtagc ataggctatc 4560
ctaatctata tctgggtagc atatgctatc ctaatctata tctgggtagt atatgctatc 4620
ctaatctgta tccgggtagc atatgctatc ctaatagaga ttagggtagt atatgctatc 4680
ctaatttata tctgggtagc atatactacc caaatatctg gatagcatat gctatcctaa 4740
tctatatctg ggtagcatat gctatcctaa tctatatctg ggtagcatag gctatcctaa 4800
tctatatctg ggtagcatat gctatcctaa tctatatctg ggtagtatat gctatcctaa 4860
tttatatctg ggtagcatag gctatcctaa tctatatctg ggtagcatat gctatcctaa 4920
tctatatctg ggtagtatat gctatcctaa tctgtatccg ggtagcatat gctatcctca 4980
tgcatataca gtcagcatat gatacccagt agtagagtgg gagtgctatc ctttgcatat 5040
gccgccacct cccaaggggg cgtgaatttt cgctgcttgt ccttttcctg ctggttgctc 5100
ccattcttag gtgaatttaa ggaggccagg ctaaagccgt cgcatgtctg attgctcacc 5160
aggtaaatgt cgctaatgtt ttccaacgcg agaaggtgtt gagcgcggag ctgagtgacg 5220
tgacaacatg ggtatgccca attgccccat gttgggagga cgaaaatggt gacaagacag 5280
atggccagaa atacaccaac agcacgcatg atgtctactg gggatttatt ctttagtgcg 5340
ggggaataca cggcttttaa tacgattgag ggcgtctcct aacaagttac atcactcctg 5400
cccttcctca ccctcatctc catcacctcc ttcatctccg tcatctccgt catcaccctc 5460
cgcggcagcc ccttccacca taggtggaaa ccagggaggc aaatctactc catcgtcaaa 5520
gctgcacaca gtcaccctga tattgcaggt aggagcgggc tttgtcataa caaggtcctt 5580
aatcgcatcc ttcaaaacct cagcaaatat atgagtttgt aaaaagacca tgaaataaca 5640
gacaatggac tcccttagcg ggccaggttg tgggccgggt ccaggggcca ttccaaaggg 5700
gagacgactc aatggtgtaa gacgacattg tggaatagca agggcagttc ctcgccttag 5760
gttgtaaagg gaggtcttac tacctccata tacgaacaca ccggcgaccc aagttccttc 5820
gtcggtagtc ctttctacgt gactcctagc caggagagct cttaaacctt ctgcaatgtt 5880
ctcaaatttc gggttggaac ctccttgacc acgatgcttt tccaaaccac cctccttttt 5940
tgcgccctgc ctccatcacc ctgaccccgg ggtccagtgc ttgggccttc tcctgggtca 6000
tctgcggggc cctgctctat cgctcccggg ggcacgtcag gctcaccatc tgggccacct 6060
tcttggtggt attcaaaata atcggcttcc cctacagggt ggaaaaatgg ccttctacct 6120
ggagggggcc tgcgcggtgg agacccggat gatgatgact gactactggg actcctgggc 6180
ctcttttctc cacgtccacg acctctcccc ctggctcttt cacgacttcc ccccctggct 6240
ctttcacgtc ctctaccccg gcggcctcca ctacctcctc gaccccggcc tccactacct 6300
cctcgacccc ggcctccact gcctcctcga ccccggcctc cacctcctgc tcctgcccct 6360
cctgctcctg cccctcctcc tgctcctgcc cctcctgccc ctcctgctcc tgcccctcct 6420
gcccctcctg ctcctgcccc tcctgcccct cctgctcctg cccctcctgc ccctcctcct 6480
gctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctgcccctcc tgctcctgcc 6540
cctcctgccc ctcctgctcc tgcccctcct gcccctcctg ctcctgcccc tcctgctcct 6600
gcccctcctg ctcctgcccc tcctgctcct gcccctcctg cccctcctgc ccctcctcct 6660
gctcctgccc ctcctgctcc tgcccctcct gcccctcctg cccctcctgc tcctgcccct 6720
cctcctgctc ctgcccctcc tgcccctcct gcccctcctc ctgctcctgc ccctcctgcc 6780
cctcctcctg ctcctgcccc tcctcctgct cctgcccctc ctgcccctcc tgcccctcct 6840
cctgctcctg cccctcctgc ccctcctcct gctcctgccc ctcctcctgc tcctgcccct 6900
cctgcccctc ctgcccctcc tcctgctcct gcccctcctc ctgctcctgc ccctcctgcc 6960
cctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctcctgctcc tgcccctcct 7020
gctcctgccc ctcccgctcc tgctcctgct cctgttccac cgtgggtccc tttgcagcca 7080
atgcaacttg gacgtttttg gggtctccgg acaccatctc tatgtcttgg ccctgatcct 7140
gagccgcccg gggctcctgg tcttccgcct cctcgtcctc gtcctcttcc ccgtcctcgt 7200
ccatggttat caccccctct tctttgaggt ccactgccgc cggagccttc tggtccagat 7260
gtgtctccct tctctcctag gccatttcca ggtcctgtac ctggcccctc gtcagacatg 7320
attcacacta aaagagatca atagacatct ttattagacg acgctcagtg aatacaggga 7380
gtgcagactc ctgccccctc caacagcccc cccaccctca tccccttcat ggtcgctgtc 7440
agacagatcc aggtctgaaa attccccatc ctccgaacca tcctcgtcct catcaccaat 7500
tactcgcagc ccggaaaact cccgctgaac atcctcaaga tttgcgtcct gagcctcaag 7560
ccaggcctca aattcctcgt cccccttttt gctggacggt agggatgggg attctcggga 7620
cccctcctct tcctcttcaa ggtcaccaga cagagatgct actggggcaa cggaagaaaa 7680
gctgggtgcg gcctgtgagg atcagcttat cgatgataag ctgtcaaaca tgagaattct 7740
tgaagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg 7800
gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta 7860
tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt 7920
caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc 7980
ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa 8040
gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt 8100
aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt 8160
ctgctatgtg gcgcggtatt atcccgtgtt gacgccgggc aagagcaact cggtcgccgc 8220
atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg 8280
gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg 8340
gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac 8400
atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca 8460
aacgacgagc gtgacaccac gatgcctgca gcaatggcaa caacgttgcg caaactatta 8520
actggcgaac tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat 8580
aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa 8640
tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag 8700
ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat 8760
agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt 8820
tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg 8880
aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga 8940
gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta 9000
atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa 9060
gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact 9120
gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca 9180
tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt 9240
accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg 9300
ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag 9360
cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta 9420
agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat 9480
ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg 9540
tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc 9600
ttttgctggc cttgaagctg tccctgatgg tcgtcatcta cctgcctgga cagcatggcc 9660
tgcaacgcgg gcatcccgat gccgccggaa gcgagaagaa tcataatggg gaaggccatc 9720
cagcctcgcg tcgcgaacgc cagcaagacg tagcccagcg cgtcggcccc gagatgcgcc 9780
gcgtgcggct gctggagatg gcggacgcga tggatatgtt ctgccaaggg ttggtttgcg 9840
cattcacagt tctccgcaag aattgattgg ctccaattct tggagtggtg aatccgttag 9900
cgaggtgccg ccctgcttca tccccgtggc ccgttgctcg cgtttgctgg cggtgtcccc 9960
ggaagaaata tatttgcatg tctttagttc tatgatgaca caaaccccgc ccagcgtctt 10020
gtcattggcg aattcgaaca cgcagatgca gtcggggcgg cgcggtccga ggtccacttc 10080
gcatattaag gtgacgcgtg tggcctcgaa caccgagcga ccctgcagcg acccgcttaa 10140
cagcgtcaac agcgtgccgc agatcccggg gggcaatgag atatgaaaaa gcctgaactc 10200
accgcgacgt ctgtcgagaa gtttctgatc gaaaagttcg acagcgtctc cgacctgatg 10260
cagctctcgg agggcgaaga atctcgtgct ttcagcttcg atgtaggagg gcgtggatat 10320
gtcctgcggg taaatagctg cgccgatggt ttctacaaag atcgttatgt ttatcggcac 10380
tttgcatcgg ccgcgctccc gattccggaa gtgcttgaca ttggggaatt cagcgagagc 10440
ctgacctatt gcatctcccg ccgtgcacag ggtgtcacgt tgcaagacct gcctgaaacc 10500
gaactgcccg ctgttctgca gccggtcgcg gaggccatgg atgcgatcgc tgcggccgat 10560
cttagccaga cgagcgggtt cggcccattc ggaccgcaag gaatcggtca atacactaca 10620
tggcgtgatt tcatatgcgc gattgctgat ccccatgtgt atcactggca aactgtgatg 10680
gacgacaccg tcagtgcgtc cgtcgcgcag gctctcgatg agctgatgct ttgggccgag 10740
gactgccccg aagtccggca cctcgtgcac gcggatttcg gctccaacaa tgtcctgacg 10800
gacaatggcc gcataacagc ggtcattgac tggagcgagg cgatgttcgg ggattcccaa 10860
tacgaggtcg ccaacatctt cttctggagg ccgtggttgg cttgtatgga gcagcagacg 10920
cgctacttcg agcggaggca tccggagctt gcaggatcgc cgcggctccg ggcgtatatg 10980
ctccgcattg gtcttgacca actctatcag agcttggttg acggcaattt cgatgatgca 11040
gcttgggcgc agggtcgatg cgacgcaatc gtccgatccg gagccgggac tgtcgggcgt 11100
acacaaatcg cccgcagaag cgcggccgtc tggaccgatg gctgtgtaga agtactcgcc 11160
gatagtggaa accgacgccc cagcactcgt ccggatcggg agatggggga ggctaactga 11220
aacacggaag gagacaatac cggaaggaac ccgcgctatg acggcaataa aaagacagaa 11280
taaaacgcac gggtgttggg tcgtttgttc ataaacgcgg ggttcggtcc cagggctggc 11340
actctgtcga taccccaccg agaccccatt ggggccaata cgcccgcgtt tcttcctttt 11400
ccccacccca ccccccaagt tcgggtgaag gcccagggct cgcagccaac gtcggggcgg 11460
caggccctgc catagccact ggccccgtgg gttagggacg gggtccccca tggggaatgg 11520
tttatggttc gtgggggtta ttattttggg cgttgcgtgg ggtcaggtcc acgactggac 11580
tgagcagaca gacccatggt ttttggatgg cctgggcatg gaccgcatgt actggcgcga 11640
cacgaacacc gggcgtctgt ggctgccaaa cacccccgac ccccaaaaac caccgcgcgg 11700
atttctggcg tgccaagcta gtcgaccaat tctcatgttt gacagcttat catcgcagat 11760
ccgggcaacg ttgttgccat tgctgcaggc gcagaactgg taggtatgga agatctatac 11820
attgaatcaa tattggcaat tagccatatt agtcattggt tatatagcat aaatcaatat 11880
tggctattgg ccattgcata cgttgtatct atatcataat atgtacattt atattggctc 11940
atgtccaata tgaccgccat                                             11960



<210> 156
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3677).

<400> 156
tcctactcct gcgagcactt ccgctggtgc aagccggtgg gatccggggg aggctccggt 60
accttagtca ccgtctcctc agagcccaaa tctgctgaca aaactcacac atgcccaccg 120
tgcccagcac ctgaagccgc cgggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa    777

<210> 157
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3677).

<400> 157
Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly Ser Gly
 1               5                  10                  15      
Gly Gly Ser Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Ala
            20                  25                  30          
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Pro Gly Lys
            


<210> 158
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3677).

<400> 158
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactcctgcg agcacttccg ctggtgcaag ccggtgggat ccgggggagg ctccggtacc 120
ttagtcaccg tctcctcaga gcccaaatct gctgacaaaa ctcacacatg cccaccgtgc 180
ccagcacctg aagccgccgg gggaccgtca gtcttcctct tccccccaaa acccaaggac 240
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 300
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 360
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 420
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 480
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 540
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 600
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 660
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 720
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 780
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       834

<210> 159
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3677).

<400> 159
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val
            20                  25                  30          
Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Thr Val Ser Ser Glu Pro
        35                  40                  45              
Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
    50                  55                  60                  
Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
65                  70                  75                  80  
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                85                  90                  95      
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            100                 105                 110         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        115                 120                 125             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    130                 135                 140                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
145                 150                 155                 160 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                165                 170                 175     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            180                 185                 190         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        195                 200                 205             

Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    210                 215                 220                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
225                 230                 235                 240 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                245                 250                 255     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            260                 265                 270         
Ser Leu Ser Pro Gly Lys
        275             


<210> 160
<211> 11969
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3677).

<400> 160
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactcctgcg agcacttccg 1680
ctggtgcaag ccggtgggat ccgggggagg ctccggtacc ttagtcaccg tctcctcaga 1740
gcccaaatct gctgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgccgg 1800
gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac 1860
ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa 1920
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta 1980
caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg 2040
caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat 2100
ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga 2160
tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga 2220
catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc 2280
cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag 2340
gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta 2400
cacgcagaag agcctctccc tgtctccggg taaatgaggg cccgtttaaa cagatccaga 2460
catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg 2520
ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa 2580
acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga 2640
ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg atccggctgc 2700
ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc 2760
acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcaggcgtc agcgggtgtt 2820
ggcgggtgtc ggggcgcagc catgaggtcg actctagagg atcgatgccc cgccccggac 2880
gaactaaacc tgactacgac atctctgccc cttcttcgcg gggcagtgca tgtaatccct 2940
tcagttggtt ggtacaactt gccaactggg ccctgttcca catgtgacac ggggggggac 3000
caaacacaaa ggggttctct gactgtagtt gacatcctta taaatggatg tgcacatttg 3060
ccaacactga gtggctttca tcctggagca gactttgcag tctgtggact gcaacacaac 3120
attgccttta tgtgtaactc ttggctgaag ctcttacacc aatgctgggg gacatgtacc 3180
tcccaggggc ccaggaagac tacgggaggc tacaccaacg tcaatcagag gggcctgtgt 3240
agctaccgat aagcggaccc tcaagagggc attagcaata gtgtttataa ggcccccttg 3300
ttaaccctaa acgggtagca tatgcttccc gggtagtagt atatactatc cagactaacc 3360
ctaattcaat agcatatgtt acccaacggg aagcatatgc tatcgaatta gggttagtaa 3420
aagggtccta aggaacagcg atatctccca ccccatgagc tgtcacggtt ttatttacat 3480
ggggtcagga ttccacgagg gtagtgaacc attttagtca caagggcagt ggctgaagat 3540
caaggagcgg gcagtgaact ctcctgaatc ttcgcctgct tcttcattct ccttcgttta 3600
gctaatagaa taactgctga gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa 3660
ggtttcaggt gacgccccca gaataaaatt tggacggggg gttcagtggt ggcattgtgc 3720
tatgacacca atataaccct cacaaacccc ttgggcaata aatactagtg taggaatgaa 3780
acattctgaa tatctttaac aatagaaatc catggggtgg ggacaagccg taaagactgg 3840
atgtccatct cacacgaatt tatggctatg ggcaacacat aatcctagtg caatatgata 3900
ctggggttat taagatgtgt cccaggcagg gaccaagaca ggtgaaccat gttgttacac 3960
tctatttgta acaaggggaa agagagtgga cgccgacagc agcggactcc actggttgtc 4020
tctaacaccc ccgaaaatta aacggggctc cacgccaatg gggcccataa acaaagacaa 4080
gtggccactc ttttttttga aattgtggag tgggggcacg cgtcagcccc cacacgccgc 4140
cctgcggttt tggactgtaa aataagggtg taataacttg gctgattgta accccgctaa 4200
ccactgcggt caaaccactt gcccacaaaa ccactaatgg caccccgggg aatacctgca 4260
taagtaggtg ggcgggccaa gataggggcg cgattgctgc gatctggagg acaaattaca 4320
cacacttgcg cctgagcgcc aagcacaggg ttgttggtcc tcatattcac gaggtcgctg 4380
agagcacggt gggctaatgt tgccatgggt agcatatact acccaaatat ctggatagca 4440
tatgctatcc taatctatat ctgggtagca taggctatcc taatctatat ctgggtagca 4500
tatgctatcc taatctatat ctgggtagta tatgctatcc taatttatat ctgggtagca 4560
taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta 4620
tatgctatcc taatctgtat ccgggtagca tatgctatcc taatagagat tagggtagta 4680
tatgctatcc taatttatat ctgggtagca tatactaccc aaatatctgg atagcatatg 4740
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagcatagg 4800
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg 4860
ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg 4920
ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg gtagcatatg 4980
ctatcctcat gcatatacag tcagcatatg atacccagta gtagagtggg agtgctatcc 5040
tttgcatatg ccgccacctc ccaagggggc gtgaattttc gctgcttgtc cttttcctgc 5100
tggttgctcc cattcttagg tgaatttaag gaggccaggc taaagccgtc gcatgtctga 5160
ttgctcacca ggtaaatgtc gctaatgttt tccaacgcga gaaggtgttg agcgcggagc 5220
tgagtgacgt gacaacatgg gtatgcccaa ttgccccatg ttgggaggac gaaaatggtg 5280
acaagacaga tggccagaaa tacaccaaca gcacgcatga tgtctactgg ggatttattc 5340
tttagtgcgg gggaatacac ggcttttaat acgattgagg gcgtctccta acaagttaca 5400
tcactcctgc ccttcctcac cctcatctcc atcacctcct tcatctccgt catctccgtc 5460
atcaccctcc gcggcagccc cttccaccat aggtggaaac cagggaggca aatctactcc 5520
atcgtcaaag ctgcacacag tcaccctgat attgcaggta ggagcgggct ttgtcataac 5580
aaggtcctta atcgcatcct tcaaaacctc agcaaatata tgagtttgta aaaagaccat 5640
gaaataacag acaatggact cccttagcgg gccaggttgt gggccgggtc caggggccat 5700
tccaaagggg agacgactca atggtgtaag acgacattgt ggaatagcaa gggcagttcc 5760
tcgccttagg ttgtaaaggg aggtcttact acctccatat acgaacacac cggcgaccca 5820
agttccttcg tcggtagtcc tttctacgtg actcctagcc aggagagctc ttaaaccttc 5880
tgcaatgttc tcaaatttcg ggttggaacc tccttgacca cgatgctttt ccaaaccacc 5940
ctcctttttt gcgccctgcc tccatcaccc tgaccccggg gtccagtgct tgggccttct 6000
cctgggtcat ctgcggggcc ctgctctatc gctcccgggg gcacgtcagg ctcaccatct 6060
gggccacctt cttggtggta ttcaaaataa tcggcttccc ctacagggtg gaaaaatggc 6120
cttctacctg gagggggcct gcgcggtgga gacccggatg atgatgactg actactggga 6180
ctcctgggcc tcttttctcc acgtccacga cctctccccc tggctctttc acgacttccc 6240
cccctggctc tttcacgtcc tctaccccgg cggcctccac tacctcctcg accccggcct 6300
ccactacctc ctcgaccccg gcctccactg cctcctcgac cccggcctcc acctcctgct 6360
cctgcccctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgctcct 6420
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6480
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6540
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6600
cctgctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc ccctcctgcc 6660
cctcctcctg ctcctgcccc tcctgctcct gcccctcctg cccctcctgc ccctcctgct 6720
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6780
cctcctgccc ctcctcctgc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6840
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6900
cctgcccctc ctgcccctcc tgcccctcct cctgctcctg cccctcctcc tgctcctgcc 6960
cctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 7020
gcccctcctg ctcctgcccc tcccgctcct gctcctgctc ctgttccacc gtgggtccct 7080
ttgcagccaa tgcaacttgg acgtttttgg ggtctccgga caccatctct atgtcttggc 7140
cctgatcctg agccgcccgg ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc 7200
cgtcctcgtc catggttatc accccctctt ctttgaggtc cactgccgcc ggagccttct 7260
ggtccagatg tgtctccctt ctctcctagg ccatttccag gtcctgtacc tggcccctcg 7320
tcagacatga ttcacactaa aagagatcaa tagacatctt tattagacga cgctcagtga 7380
atacagggag tgcagactcc tgccccctcc aacagccccc ccaccctcat ccccttcatg 7440
gtcgctgtca gacagatcca ggtctgaaaa ttccccatcc tccgaaccat cctcgtcctc 7500
atcaccaatt actcgcagcc cggaaaactc ccgctgaaca tcctcaagat ttgcgtcctg 7560
agcctcaagc caggcctcaa attcctcgtc cccctttttg ctggacggta gggatgggga 7620
ttctcgggac ccctcctctt cctcttcaag gtcaccagac agagatgcta ctggggcaac 7680
ggaagaaaag ctgggtgcgg cctgtgagga tcagcttatc gatgataagc tgtcaaacat 7740
gagaattctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg 7800
ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct 7860
atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 7920
taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc 7980
cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg 8040
aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc 8100
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact 8160
tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc 8220
ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag 8280
catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat 8340
aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt 8400
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa 8460
gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc 8520
aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg 8580
gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt 8640
gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca 8700
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat 8760
gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca 8820
gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg 8880
atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg 8940
ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt 9000
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg 9060
ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata 9120
ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca 9180
ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag 9240
tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc 9300
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga 9360
tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg 9420
tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac 9480
gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg 9540
tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg 9600
ttcctggcct tttgctggcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac 9660
agcatggcct gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg 9720
aaggccatcc agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccccg 9780
agatgcgccg cgtgcggctg ctggagatgg cggacgcgat ggatatgttc tgccaagggt 9840
tggtttgcgc attcacagtt ctccgcaaga attgattggc tccaattctt ggagtggtga 9900
atccgttagc gaggtgccgc cctgcttcat ccccgtggcc cgttgctcgc gtttgctggc 9960
ggtgtccccg gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc 10020
cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag 10080
gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga 10140
cccgcttaac agcgtcaaca gcgtgccgca gatcccgggg ggcaatgaga tatgaaaaag 10200
cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc 10260
gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg 10320
cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga tcgttatgtt 10380
tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat tggggaattc 10440
agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg 10500
cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct 10560
gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa 10620
tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta tcactggcaa 10680
actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt 10740
tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg ctccaacaat 10800
gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc gatgttcggg 10860
gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc ttgtatggag 10920
cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc gcggctccgg 10980
gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga cggcaatttc 11040
gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg agccgggact 11100
gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa 11160
gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cggatcggga gatgggggag 11220
gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga cggcaataaa 11280
aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg gttcggtccc 11340
agggctggca ctctgtcgat accccaccga gaccccattg gggccaatac gcccgcgttt 11400
cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc gcagccaacg 11460
tcggggcggc aggccctgcc atagccactg gccccgtggg ttagggacgg ggtcccccat 11520
ggggaatggt ttatggttcg tgggggttat tattttgggc gttgcgtggg gtcaggtcca 11580
cgactggact gagcagacag acccatggtt tttggatggc ctgggcatgg accgcatgta 11640
ctggcgcgac acgaacaccg ggcgtctgtg gctgccaaac acccccgacc cccaaaaacc 11700
accgcgcgga tttctggcgt gccaagctag tcgaccaatt ctcatgtttg acagcttatc 11760
atcgcagatc cgggcaacgt tgttgccatt gctgcaggcg cagaactggt aggtatggaa 11820
gatctataca ttgaatcaat attggcaatt agccatatta gtcattggtt atatagcata 11880
aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta 11940
tattggctca tgtccaatat gaccgccat                                   11969



<210> 161
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3160).

<400> 161
tcctactgca tggagcactt ccgctggtgc aagccggtgg gatccggtgg aggctccggt 60
accttagtcg ccgtctcctc agagcccaaa tctgccgaca aaactcacgc ctgcccaccg 120
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa    777

<210> 162
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3160).

<400> 162
Ser Tyr Cys Met Glu His Phe Arg Trp Cys Lys Pro Val Gly Ser Gly
 1               5                  10                  15      
Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro Lys Ser Ala
            20                  25                  30          
Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Pro Gly Lys
            


<210> 163
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3160).

<400> 163
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactgcatgg agcacttccg ctggtgcaag ccggtgggat ccggtggagg ctccggtacc 120
ttagtcgccg tctcctcaga gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc 180
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 240
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 300
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 360
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 420
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 480
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 540
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 600
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 660
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 720
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 780
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       834

<210> 164
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3160).

<400> 164
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Cys Met Glu His Phe Arg Trp Cys Lys Pro Val
            20                  25                  30          
Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro
        35                  40                  45              
Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu
    50                  55                  60                  
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
65                  70                  75                  80  
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                85                  90                  95      
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            100                 105                 110         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        115                 120                 125             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    130                 135                 140                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
145                 150                 155                 160 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                165                 170                 175     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            180                 185                 190         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        195                 200                 205             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    210                 215                 220                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
225                 230                 235                 240 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                245                 250                 255     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            260                 265                 270         
Ser Leu Ser Pro Gly Lys
        275             


<210> 165
<211> 11969
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3160).

<400> 165
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactgcatgg agcacttccg 1680
ctggtgcaag ccggtgggat ccggtggagg ctccggtacc ttagtcgccg tctcctcaga 1740
gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc ccagcacctg aactcctggg 1800
gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac 1860
ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa 1920
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta 1980
caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg 2040
caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat 2100
ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga 2160
tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga 2220
catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc 2280
cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag 2340
gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta 2400
cacgcagaag agcctctccc tgtctccggg taaatgaggg cccgtttaaa cagatccaga 2460
catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg 2520
ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa 2580
acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga 2640
ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg atccggctgc 2700
ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc 2760
acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcaggcgtc agcgggtgtt 2820
ggcgggtgtc ggggcgcagc catgaggtcg actctagagg atcgatgccc cgccccggac 2880
gaactaaacc tgactacgac atctctgccc cttcttcgcg gggcagtgca tgtaatccct 2940
tcagttggtt ggtacaactt gccaactggg ccctgttcca catgtgacac ggggggggac 3000
caaacacaaa ggggttctct gactgtagtt gacatcctta taaatggatg tgcacatttg 3060
ccaacactga gtggctttca tcctggagca gactttgcag tctgtggact gcaacacaac 3120
attgccttta tgtgtaactc ttggctgaag ctcttacacc aatgctgggg gacatgtacc 3180
tcccaggggc ccaggaagac tacgggaggc tacaccaacg tcaatcagag gggcctgtgt 3240
agctaccgat aagcggaccc tcaagagggc attagcaata gtgtttataa ggcccccttg 3300
ttaaccctaa acgggtagca tatgcttccc gggtagtagt atatactatc cagactaacc 3360
ctaattcaat agcatatgtt acccaacggg aagcatatgc tatcgaatta gggttagtaa 3420
aagggtccta aggaacagcg atatctccca ccccatgagc tgtcacggtt ttatttacat 3480
ggggtcagga ttccacgagg gtagtgaacc attttagtca caagggcagt ggctgaagat 3540
caaggagcgg gcagtgaact ctcctgaatc ttcgcctgct tcttcattct ccttcgttta 3600
gctaatagaa taactgctga gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa 3660
ggtttcaggt gacgccccca gaataaaatt tggacggggg gttcagtggt ggcattgtgc 3720
tatgacacca atataaccct cacaaacccc ttgggcaata aatactagtg taggaatgaa 3780
acattctgaa tatctttaac aatagaaatc catggggtgg ggacaagccg taaagactgg 3840
atgtccatct cacacgaatt tatggctatg ggcaacacat aatcctagtg caatatgata 3900
ctggggttat taagatgtgt cccaggcagg gaccaagaca ggtgaaccat gttgttacac 3960
tctatttgta acaaggggaa agagagtgga cgccgacagc agcggactcc actggttgtc 4020
tctaacaccc ccgaaaatta aacggggctc cacgccaatg gggcccataa acaaagacaa 4080
gtggccactc ttttttttga aattgtggag tgggggcacg cgtcagcccc cacacgccgc 4140
cctgcggttt tggactgtaa aataagggtg taataacttg gctgattgta accccgctaa 4200
ccactgcggt caaaccactt gcccacaaaa ccactaatgg caccccgggg aatacctgca 4260
taagtaggtg ggcgggccaa gataggggcg cgattgctgc gatctggagg acaaattaca 4320
cacacttgcg cctgagcgcc aagcacaggg ttgttggtcc tcatattcac gaggtcgctg 4380
agagcacggt gggctaatgt tgccatgggt agcatatact acccaaatat ctggatagca 4440
tatgctatcc taatctatat ctgggtagca taggctatcc taatctatat ctgggtagca 4500
tatgctatcc taatctatat ctgggtagta tatgctatcc taatttatat ctgggtagca 4560
taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta 4620
tatgctatcc taatctgtat ccgggtagca tatgctatcc taatagagat tagggtagta 4680
tatgctatcc taatttatat ctgggtagca tatactaccc aaatatctgg atagcatatg 4740
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagcatagg 4800
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg 4860
ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg 4920
ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg gtagcatatg 4980
ctatcctcat gcatatacag tcagcatatg atacccagta gtagagtggg agtgctatcc 5040
tttgcatatg ccgccacctc ccaagggggc gtgaattttc gctgcttgtc cttttcctgc 5100
tggttgctcc cattcttagg tgaatttaag gaggccaggc taaagccgtc gcatgtctga 5160
ttgctcacca ggtaaatgtc gctaatgttt tccaacgcga gaaggtgttg agcgcggagc 5220
tgagtgacgt gacaacatgg gtatgcccaa ttgccccatg ttgggaggac gaaaatggtg 5280
acaagacaga tggccagaaa tacaccaaca gcacgcatga tgtctactgg ggatttattc 5340
tttagtgcgg gggaatacac ggcttttaat acgattgagg gcgtctccta acaagttaca 5400
tcactcctgc ccttcctcac cctcatctcc atcacctcct tcatctccgt catctccgtc 5460
atcaccctcc gcggcagccc cttccaccat aggtggaaac cagggaggca aatctactcc 5520
atcgtcaaag ctgcacacag tcaccctgat attgcaggta ggagcgggct ttgtcataac 5580
aaggtcctta atcgcatcct tcaaaacctc agcaaatata tgagtttgta aaaagaccat 5640
gaaataacag acaatggact cccttagcgg gccaggttgt gggccgggtc caggggccat 5700
tccaaagggg agacgactca atggtgtaag acgacattgt ggaatagcaa gggcagttcc 5760
tcgccttagg ttgtaaaggg aggtcttact acctccatat acgaacacac cggcgaccca 5820
agttccttcg tcggtagtcc tttctacgtg actcctagcc aggagagctc ttaaaccttc 5880
tgcaatgttc tcaaatttcg ggttggaacc tccttgacca cgatgctttt ccaaaccacc 5940
ctcctttttt gcgccctgcc tccatcaccc tgaccccggg gtccagtgct tgggccttct 6000
cctgggtcat ctgcggggcc ctgctctatc gctcccgggg gcacgtcagg ctcaccatct 6060
gggccacctt cttggtggta ttcaaaataa tcggcttccc ctacagggtg gaaaaatggc 6120
cttctacctg gagggggcct gcgcggtgga gacccggatg atgatgactg actactggga 6180
ctcctgggcc tcttttctcc acgtccacga cctctccccc tggctctttc acgacttccc 6240
cccctggctc tttcacgtcc tctaccccgg cggcctccac tacctcctcg accccggcct 6300
ccactacctc ctcgaccccg gcctccactg cctcctcgac cccggcctcc acctcctgct 6360
cctgcccctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgctcct 6420
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6480
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6540
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6600
cctgctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc ccctcctgcc 6660
cctcctcctg ctcctgcccc tcctgctcct gcccctcctg cccctcctgc ccctcctgct 6720
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6780
cctcctgccc ctcctcctgc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6840
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6900
cctgcccctc ctgcccctcc tgcccctcct cctgctcctg cccctcctcc tgctcctgcc 6960
cctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 7020
gcccctcctg ctcctgcccc tcccgctcct gctcctgctc ctgttccacc gtgggtccct 7080
ttgcagccaa tgcaacttgg acgtttttgg ggtctccgga caccatctct atgtcttggc 7140
cctgatcctg agccgcccgg ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc 7200
cgtcctcgtc catggttatc accccctctt ctttgaggtc cactgccgcc ggagccttct 7260
ggtccagatg tgtctccctt ctctcctagg ccatttccag gtcctgtacc tggcccctcg 7320
tcagacatga ttcacactaa aagagatcaa tagacatctt tattagacga cgctcagtga 7380
atacagggag tgcagactcc tgccccctcc aacagccccc ccaccctcat ccccttcatg 7440
gtcgctgtca gacagatcca ggtctgaaaa ttccccatcc tccgaaccat cctcgtcctc 7500
atcaccaatt actcgcagcc cggaaaactc ccgctgaaca tcctcaagat ttgcgtcctg 7560
agcctcaagc caggcctcaa attcctcgtc cccctttttg ctggacggta gggatgggga 7620
ttctcgggac ccctcctctt cctcttcaag gtcaccagac agagatgcta ctggggcaac 7680
ggaagaaaag ctgggtgcgg cctgtgagga tcagcttatc gatgataagc tgtcaaacat 7740
gagaattctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg 7800
ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct 7860
atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 7920
taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc 7980
cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg 8040
aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc 8100
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact 8160
tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc 8220
ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag 8280
catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat 8340
aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt 8400
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa 8460
gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc 8520
aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg 8580
gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt 8640
gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca 8700
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat 8760
gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca 8820
gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg 8880
atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg 8940
ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt 9000
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg 9060
ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata 9120
ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca 9180
ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag 9240
tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc 9300
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga 9360
tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg 9420
tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac 9480
gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg 9540
tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg 9600
ttcctggcct tttgctggcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac 9660
agcatggcct gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg 9720
aaggccatcc agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccccg 9780
agatgcgccg cgtgcggctg ctggagatgg cggacgcgat ggatatgttc tgccaagggt 9840
tggtttgcgc attcacagtt ctccgcaaga attgattggc tccaattctt ggagtggtga 9900
atccgttagc gaggtgccgc cctgcttcat ccccgtggcc cgttgctcgc gtttgctggc 9960
ggtgtccccg gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc 10020
cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag 10080
gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga 10140
cccgcttaac agcgtcaaca gcgtgccgca gatcccgggg ggcaatgaga tatgaaaaag 10200
cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc 10260
gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg 10320
cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga tcgttatgtt 10380
tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat tggggaattc 10440
agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg 10500
cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct 10560
gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa 10620
tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta tcactggcaa 10680
actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt 10740
tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg ctccaacaat 10800
gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc gatgttcggg 10860
gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc ttgtatggag 10920
cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc gcggctccgg 10980
gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga cggcaatttc 11040
gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg agccgggact 11100
gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa 11160
gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cggatcggga gatgggggag 11220
gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga cggcaataaa 11280
aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg gttcggtccc 11340
agggctggca ctctgtcgat accccaccga gaccccattg gggccaatac gcccgcgttt 11400
cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc gcagccaacg 11460
tcggggcggc aggccctgcc atagccactg gccccgtggg ttagggacgg ggtcccccat 11520
ggggaatggt ttatggttcg tgggggttat tattttgggc gttgcgtggg gtcaggtcca 11580
cgactggact gagcagacag acccatggtt tttggatggc ctgggcatgg accgcatgta 11640
ctggcgcgac acgaacaccg ggcgtctgtg gctgccaaac acccccgacc cccaaaaacc 11700
accgcgcgga tttctggcgt gccaagctag tcgaccaatt ctcatgtttg acagcttatc 11760
atcgcagatc cgggcaacgt tgttgccatt gctgcaggcg cagaactggt aggtatggaa 11820
gatctataca ttgaatcaat attggcaatt agccatatta gtcattggtt atatagcata 11880
aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta 11940
tattggctca tgtccaatat gaccgccat                                   11969



<210> 166
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3161).

<400> 166
tcctgctcca tggagcactt ccgctggtgc aagccggtgg gatccggtgg aggctccggt 60
accttagtcg ccgtctcctc agagcccaaa tctgccgaca aaactcacgc ctgcccaccg 120
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa    777

<210> 167
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3161).

<400> 167
Ser Cys Ser Met Glu His Phe Arg Trp Cys Lys Pro Val Gly Ser Gly
 1               5                  10                  15      
Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro Lys Ser Ala
            20                  25                  30          
Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Pro Gly Lys
            


<210> 168
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3161).

<400> 168
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tgctccatgg agcacttccg ctggtgcaag ccggtgggat ccggtggagg ctccggtacc 120
ttagtcgccg tctcctcaga gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc 180
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 240
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 300
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 360
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 420
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 480
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 540
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 600
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 660
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 720
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 780
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       834

<210> 169
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3161).

<400> 169
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Cys Ser Met Glu His Phe Arg Trp Cys Lys Pro Val
            20                  25                  30          
Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro
        35                  40                  45              
Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu
    50                  55                  60                  
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
65                  70                  75                  80  
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                85                  90                  95      
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            100                 105                 110         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        115                 120                 125             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    130                 135                 140                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
145                 150                 155                 160 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                165                 170                 175     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            180                 185                 190         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        195                 200                 205             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    210                 215                 220                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
225                 230                 235                 240 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                245                 250                 255     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            260                 265                 270         
Ser Leu Ser Pro Gly Lys
        275             


<210> 170
<211> 11969
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3161).
      
      

<400> 170
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tgctccatgg agcacttccg 1680
ctggtgcaag ccggtgggat ccggtggagg ctccggtacc ttagtcgccg tctcctcaga 1740
gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc ccagcacctg aactcctggg 1800
gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac 1860
ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa 1920
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta 1980
caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg 2040
caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat 2100
ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga 2160
tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga 2220
catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc 2280
cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag 2340
gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta 2400
cacgcagaag agcctctccc tgtctccggg taaatgaggg cccgtttaaa cagatccaga 2460
catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg 2520
ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa 2580
acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga 2640
ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg atccggctgc 2700
ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc 2760
acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcaggcgtc agcgggtgtt 2820
ggcgggtgtc ggggcgcagc catgaggtcg actctagagg atcgatgccc cgccccggac 2880
gaactaaacc tgactacgac atctctgccc cttcttcgcg gggcagtgca tgtaatccct 2940
tcagttggtt ggtacaactt gccaactggg ccctgttcca catgtgacac ggggggggac 3000
caaacacaaa ggggttctct gactgtagtt gacatcctta taaatggatg tgcacatttg 3060
ccaacactga gtggctttca tcctggagca gactttgcag tctgtggact gcaacacaac 3120
attgccttta tgtgtaactc ttggctgaag ctcttacacc aatgctgggg gacatgtacc 3180
tcccaggggc ccaggaagac tacgggaggc tacaccaacg tcaatcagag gggcctgtgt 3240
agctaccgat aagcggaccc tcaagagggc attagcaata gtgtttataa ggcccccttg 3300
ttaaccctaa acgggtagca tatgcttccc gggtagtagt atatactatc cagactaacc 3360
ctaattcaat agcatatgtt acccaacggg aagcatatgc tatcgaatta gggttagtaa 3420
aagggtccta aggaacagcg atatctccca ccccatgagc tgtcacggtt ttatttacat 3480
ggggtcagga ttccacgagg gtagtgaacc attttagtca caagggcagt ggctgaagat 3540
caaggagcgg gcagtgaact ctcctgaatc ttcgcctgct tcttcattct ccttcgttta 3600
gctaatagaa taactgctga gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa 3660
ggtttcaggt gacgccccca gaataaaatt tggacggggg gttcagtggt ggcattgtgc 3720
tatgacacca atataaccct cacaaacccc ttgggcaata aatactagtg taggaatgaa 3780
acattctgaa tatctttaac aatagaaatc catggggtgg ggacaagccg taaagactgg 3840
atgtccatct cacacgaatt tatggctatg ggcaacacat aatcctagtg caatatgata 3900
ctggggttat taagatgtgt cccaggcagg gaccaagaca ggtgaaccat gttgttacac 3960
tctatttgta acaaggggaa agagagtgga cgccgacagc agcggactcc actggttgtc 4020
tctaacaccc ccgaaaatta aacggggctc cacgccaatg gggcccataa acaaagacaa 4080
gtggccactc ttttttttga aattgtggag tgggggcacg cgtcagcccc cacacgccgc 4140
cctgcggttt tggactgtaa aataagggtg taataacttg gctgattgta accccgctaa 4200
ccactgcggt caaaccactt gcccacaaaa ccactaatgg caccccgggg aatacctgca 4260
taagtaggtg ggcgggccaa gataggggcg cgattgctgc gatctggagg acaaattaca 4320
cacacttgcg cctgagcgcc aagcacaggg ttgttggtcc tcatattcac gaggtcgctg 4380
agagcacggt gggctaatgt tgccatgggt agcatatact acccaaatat ctggatagca 4440
tatgctatcc taatctatat ctgggtagca taggctatcc taatctatat ctgggtagca 4500
tatgctatcc taatctatat ctgggtagta tatgctatcc taatttatat ctgggtagca 4560
taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta 4620
tatgctatcc taatctgtat ccgggtagca tatgctatcc taatagagat tagggtagta 4680
tatgctatcc taatttatat ctgggtagca tatactaccc aaatatctgg atagcatatg 4740
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagcatagg 4800
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg 4860
ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg 4920
ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg gtagcatatg 4980
ctatcctcat gcatatacag tcagcatatg atacccagta gtagagtggg agtgctatcc 5040
tttgcatatg ccgccacctc ccaagggggc gtgaattttc gctgcttgtc cttttcctgc 5100
tggttgctcc cattcttagg tgaatttaag gaggccaggc taaagccgtc gcatgtctga 5160
ttgctcacca ggtaaatgtc gctaatgttt tccaacgcga gaaggtgttg agcgcggagc 5220
tgagtgacgt gacaacatgg gtatgcccaa ttgccccatg ttgggaggac gaaaatggtg 5280
acaagacaga tggccagaaa tacaccaaca gcacgcatga tgtctactgg ggatttattc 5340
tttagtgcgg gggaatacac ggcttttaat acgattgagg gcgtctccta acaagttaca 5400
tcactcctgc ccttcctcac cctcatctcc atcacctcct tcatctccgt catctccgtc 5460
atcaccctcc gcggcagccc cttccaccat aggtggaaac cagggaggca aatctactcc 5520
atcgtcaaag ctgcacacag tcaccctgat attgcaggta ggagcgggct ttgtcataac 5580
aaggtcctta atcgcatcct tcaaaacctc agcaaatata tgagtttgta aaaagaccat 5640
gaaataacag acaatggact cccttagcgg gccaggttgt gggccgggtc caggggccat 5700
tccaaagggg agacgactca atggtgtaag acgacattgt ggaatagcaa gggcagttcc 5760
tcgccttagg ttgtaaaggg aggtcttact acctccatat acgaacacac cggcgaccca 5820
agttccttcg tcggtagtcc tttctacgtg actcctagcc aggagagctc ttaaaccttc 5880
tgcaatgttc tcaaatttcg ggttggaacc tccttgacca cgatgctttt ccaaaccacc 5940
ctcctttttt gcgccctgcc tccatcaccc tgaccccggg gtccagtgct tgggccttct 6000
cctgggtcat ctgcggggcc ctgctctatc gctcccgggg gcacgtcagg ctcaccatct 6060
gggccacctt cttggtggta ttcaaaataa tcggcttccc ctacagggtg gaaaaatggc 6120
cttctacctg gagggggcct gcgcggtgga gacccggatg atgatgactg actactggga 6180
ctcctgggcc tcttttctcc acgtccacga cctctccccc tggctctttc acgacttccc 6240
cccctggctc tttcacgtcc tctaccccgg cggcctccac tacctcctcg accccggcct 6300
ccactacctc ctcgaccccg gcctccactg cctcctcgac cccggcctcc acctcctgct 6360
cctgcccctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgctcct 6420
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6480
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6540
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6600
cctgctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc ccctcctgcc 6660
cctcctcctg ctcctgcccc tcctgctcct gcccctcctg cccctcctgc ccctcctgct 6720
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6780
cctcctgccc ctcctcctgc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6840
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6900
cctgcccctc ctgcccctcc tgcccctcct cctgctcctg cccctcctcc tgctcctgcc 6960
cctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 7020
gcccctcctg ctcctgcccc tcccgctcct gctcctgctc ctgttccacc gtgggtccct 7080
ttgcagccaa tgcaacttgg acgtttttgg ggtctccgga caccatctct atgtcttggc 7140
cctgatcctg agccgcccgg ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc 7200
cgtcctcgtc catggttatc accccctctt ctttgaggtc cactgccgcc ggagccttct 7260
ggtccagatg tgtctccctt ctctcctagg ccatttccag gtcctgtacc tggcccctcg 7320
tcagacatga ttcacactaa aagagatcaa tagacatctt tattagacga cgctcagtga 7380
atacagggag tgcagactcc tgccccctcc aacagccccc ccaccctcat ccccttcatg 7440
gtcgctgtca gacagatcca ggtctgaaaa ttccccatcc tccgaaccat cctcgtcctc 7500
atcaccaatt actcgcagcc cggaaaactc ccgctgaaca tcctcaagat ttgcgtcctg 7560
agcctcaagc caggcctcaa attcctcgtc cccctttttg ctggacggta gggatgggga 7620
ttctcgggac ccctcctctt cctcttcaag gtcaccagac agagatgcta ctggggcaac 7680
ggaagaaaag ctgggtgcgg cctgtgagga tcagcttatc gatgataagc tgtcaaacat 7740
gagaattctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg 7800
ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct 7860
atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 7920
taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc 7980
cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg 8040
aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc 8100
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact 8160
tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc 8220
ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag 8280
catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat 8340
aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt 8400
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa 8460
gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc 8520
aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg 8580
gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt 8640
gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca 8700
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat 8760
gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca 8820
gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg 8880
atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg 8940
ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt 9000
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg 9060
ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata 9120
ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca 9180
ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag 9240
tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc 9300
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga 9360
tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg 9420
tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac 9480
gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg 9540
tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg 9600
ttcctggcct tttgctggcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac 9660
agcatggcct gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg 9720
aaggccatcc agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccccg 9780
agatgcgccg cgtgcggctg ctggagatgg cggacgcgat ggatatgttc tgccaagggt 9840
tggtttgcgc attcacagtt ctccgcaaga attgattggc tccaattctt ggagtggtga 9900
atccgttagc gaggtgccgc cctgcttcat ccccgtggcc cgttgctcgc gtttgctggc 9960
ggtgtccccg gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc 10020
cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag 10080
gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga 10140
cccgcttaac agcgtcaaca gcgtgccgca gatcccgggg ggcaatgaga tatgaaaaag 10200
cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc 10260
gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg 10320
cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga tcgttatgtt 10380
tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat tggggaattc 10440
agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg 10500
cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct 10560
gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa 10620
tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta tcactggcaa 10680
actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt 10740
tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg ctccaacaat 10800
gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc gatgttcggg 10860
gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc ttgtatggag 10920
cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc gcggctccgg 10980
gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga cggcaatttc 11040
gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg agccgggact 11100
gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa 11160
gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cggatcggga gatgggggag 11220
gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga cggcaataaa 11280
aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg gttcggtccc 11340
agggctggca ctctgtcgat accccaccga gaccccattg gggccaatac gcccgcgttt 11400
cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc gcagccaacg 11460
tcggggcggc aggccctgcc atagccactg gccccgtggg ttagggacgg ggtcccccat 11520
ggggaatggt ttatggttcg tgggggttat tattttgggc gttgcgtggg gtcaggtcca 11580
cgactggact gagcagacag acccatggtt tttggatggc ctgggcatgg accgcatgta 11640
ctggcgcgac acgaacaccg ggcgtctgtg gctgccaaac acccccgacc cccaaaaacc 11700
accgcgcgga tttctggcgt gccaagctag tcgaccaatt ctcatgtttg acagcttatc 11760
atcgcagatc cgggcaacgt tgttgccatt gctgcaggcg cagaactggt aggtatggaa 11820
gatctataca ttgaatcaat attggcaatt agccatatta gtcattggtt atatagcata 11880
aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta 11940
tattggctca tgtccaatat gaccgccat                                   11969



<210> 171
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3215).
      
      

<400> 171
tcctactcct gcgagcactt ccgctggggc tgcccggtgg gatccggtgg aggctccggt 60
accttagtcg ccgtctcctc agagcccaaa tctgccgaca aaactcacgc ctgcccaccg 120
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa    777

<210> 172
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3215).
      
      

<400> 172
Ser Tyr Ser Cys Glu His Phe Arg Trp Gly Cys Pro Val Gly Ser Gly
 1               5                  10                  15      
Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro Lys Ser Ala
            20                  25                  30          
Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Pro Gly Lys
            


<210> 173
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3215).
      
      

<400> 173
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactcctgcg agcacttccg ctggggctgc ccggtgggat ccggtggagg ctccggtacc 120
ttagtcgccg tctcctcaga gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc 180
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 240
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 300
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 360
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 420
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 480
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 540
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 600
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 660
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 720
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 780
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       834

<210> 174
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3215).
      

<400> 174
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Cys Glu His Phe Arg Trp Gly Cys Pro Val
            20                  25                  30          
Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro
        35                  40                  45              
Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu
    50                  55                  60                  
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
65                  70                  75                  80  
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                85                  90                  95      
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            100                 105                 110         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        115                 120                 125             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    130                 135                 140                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
145                 150                 155                 160 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                165                 170                 175     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            180                 185                 190         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        195                 200                 205             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    210                 215                 220                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
225                 230                 235                 240 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                245                 250                 255     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            260                 265                 270         
Ser Leu Ser Pro Gly Lys
        275             


<210> 175
<211> 11969
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3215).
      

<400> 175
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactcctgcg agcacttccg 1680
ctggggctgc ccggtgggat ccggtggagg ctccggtacc ttagtcgccg tctcctcaga 1740
gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc ccagcacctg aactcctggg 1800
gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac 1860
ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa 1920
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta 1980
caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg 2040
caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat 2100
ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga 2160
tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga 2220
catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc 2280
cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag 2340
gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta 2400
cacgcagaag agcctctccc tgtctccggg taaatgaggg cccgtttaaa cagatccaga 2460
catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg 2520
ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa 2580
acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga 2640
ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg atccggctgc 2700
ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc 2760
acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcaggcgtc agcgggtgtt 2820
ggcgggtgtc ggggcgcagc catgaggtcg actctagagg atcgatgccc cgccccggac 2880
gaactaaacc tgactacgac atctctgccc cttcttcgcg gggcagtgca tgtaatccct 2940
tcagttggtt ggtacaactt gccaactggg ccctgttcca catgtgacac ggggggggac 3000
caaacacaaa ggggttctct gactgtagtt gacatcctta taaatggatg tgcacatttg 3060
ccaacactga gtggctttca tcctggagca gactttgcag tctgtggact gcaacacaac 3120
attgccttta tgtgtaactc ttggctgaag ctcttacacc aatgctgggg gacatgtacc 3180
tcccaggggc ccaggaagac tacgggaggc tacaccaacg tcaatcagag gggcctgtgt 3240
agctaccgat aagcggaccc tcaagagggc attagcaata gtgtttataa ggcccccttg 3300
ttaaccctaa acgggtagca tatgcttccc gggtagtagt atatactatc cagactaacc 3360
ctaattcaat agcatatgtt acccaacggg aagcatatgc tatcgaatta gggttagtaa 3420
aagggtccta aggaacagcg atatctccca ccccatgagc tgtcacggtt ttatttacat 3480
ggggtcagga ttccacgagg gtagtgaacc attttagtca caagggcagt ggctgaagat 3540
caaggagcgg gcagtgaact ctcctgaatc ttcgcctgct tcttcattct ccttcgttta 3600
gctaatagaa taactgctga gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa 3660
ggtttcaggt gacgccccca gaataaaatt tggacggggg gttcagtggt ggcattgtgc 3720
tatgacacca atataaccct cacaaacccc ttgggcaata aatactagtg taggaatgaa 3780
acattctgaa tatctttaac aatagaaatc catggggtgg ggacaagccg taaagactgg 3840
atgtccatct cacacgaatt tatggctatg ggcaacacat aatcctagtg caatatgata 3900
ctggggttat taagatgtgt cccaggcagg gaccaagaca ggtgaaccat gttgttacac 3960
tctatttgta acaaggggaa agagagtgga cgccgacagc agcggactcc actggttgtc 4020
tctaacaccc ccgaaaatta aacggggctc cacgccaatg gggcccataa acaaagacaa 4080
gtggccactc ttttttttga aattgtggag tgggggcacg cgtcagcccc cacacgccgc 4140
cctgcggttt tggactgtaa aataagggtg taataacttg gctgattgta accccgctaa 4200
ccactgcggt caaaccactt gcccacaaaa ccactaatgg caccccgggg aatacctgca 4260
taagtaggtg ggcgggccaa gataggggcg cgattgctgc gatctggagg acaaattaca 4320
cacacttgcg cctgagcgcc aagcacaggg ttgttggtcc tcatattcac gaggtcgctg 4380
agagcacggt gggctaatgt tgccatgggt agcatatact acccaaatat ctggatagca 4440
tatgctatcc taatctatat ctgggtagca taggctatcc taatctatat ctgggtagca 4500
tatgctatcc taatctatat ctgggtagta tatgctatcc taatttatat ctgggtagca 4560
taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta 4620
tatgctatcc taatctgtat ccgggtagca tatgctatcc taatagagat tagggtagta 4680
tatgctatcc taatttatat ctgggtagca tatactaccc aaatatctgg atagcatatg 4740
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagcatagg 4800
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg 4860
ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg 4920
ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg gtagcatatg 4980
ctatcctcat gcatatacag tcagcatatg atacccagta gtagagtggg agtgctatcc 5040
tttgcatatg ccgccacctc ccaagggggc gtgaattttc gctgcttgtc cttttcctgc 5100
tggttgctcc cattcttagg tgaatttaag gaggccaggc taaagccgtc gcatgtctga 5160
ttgctcacca ggtaaatgtc gctaatgttt tccaacgcga gaaggtgttg agcgcggagc 5220
tgagtgacgt gacaacatgg gtatgcccaa ttgccccatg ttgggaggac gaaaatggtg 5280
acaagacaga tggccagaaa tacaccaaca gcacgcatga tgtctactgg ggatttattc 5340
tttagtgcgg gggaatacac ggcttttaat acgattgagg gcgtctccta acaagttaca 5400
tcactcctgc ccttcctcac cctcatctcc atcacctcct tcatctccgt catctccgtc 5460
atcaccctcc gcggcagccc cttccaccat aggtggaaac cagggaggca aatctactcc 5520
atcgtcaaag ctgcacacag tcaccctgat attgcaggta ggagcgggct ttgtcataac 5580
aaggtcctta atcgcatcct tcaaaacctc agcaaatata tgagtttgta aaaagaccat 5640
gaaataacag acaatggact cccttagcgg gccaggttgt gggccgggtc caggggccat 5700
tccaaagggg agacgactca atggtgtaag acgacattgt ggaatagcaa gggcagttcc 5760
tcgccttagg ttgtaaaggg aggtcttact acctccatat acgaacacac cggcgaccca 5820
agttccttcg tcggtagtcc tttctacgtg actcctagcc aggagagctc ttaaaccttc 5880
tgcaatgttc tcaaatttcg ggttggaacc tccttgacca cgatgctttt ccaaaccacc 5940
ctcctttttt gcgccctgcc tccatcaccc tgaccccggg gtccagtgct tgggccttct 6000
cctgggtcat ctgcggggcc ctgctctatc gctcccgggg gcacgtcagg ctcaccatct 6060
gggccacctt cttggtggta ttcaaaataa tcggcttccc ctacagggtg gaaaaatggc 6120
cttctacctg gagggggcct gcgcggtgga gacccggatg atgatgactg actactggga 6180
ctcctgggcc tcttttctcc acgtccacga cctctccccc tggctctttc acgacttccc 6240
cccctggctc tttcacgtcc tctaccccgg cggcctccac tacctcctcg accccggcct 6300
ccactacctc ctcgaccccg gcctccactg cctcctcgac cccggcctcc acctcctgct 6360
cctgcccctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgctcct 6420
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6480
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6540
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6600
cctgctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc ccctcctgcc 6660
cctcctcctg ctcctgcccc tcctgctcct gcccctcctg cccctcctgc ccctcctgct 6720
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6780
cctcctgccc ctcctcctgc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6840
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6900
cctgcccctc ctgcccctcc tgcccctcct cctgctcctg cccctcctcc tgctcctgcc 6960
cctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 7020
gcccctcctg ctcctgcccc tcccgctcct gctcctgctc ctgttccacc gtgggtccct 7080
ttgcagccaa tgcaacttgg acgtttttgg ggtctccgga caccatctct atgtcttggc 7140
cctgatcctg agccgcccgg ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc 7200
cgtcctcgtc catggttatc accccctctt ctttgaggtc cactgccgcc ggagccttct 7260
ggtccagatg tgtctccctt ctctcctagg ccatttccag gtcctgtacc tggcccctcg 7320
tcagacatga ttcacactaa aagagatcaa tagacatctt tattagacga cgctcagtga 7380
atacagggag tgcagactcc tgccccctcc aacagccccc ccaccctcat ccccttcatg 7440
gtcgctgtca gacagatcca ggtctgaaaa ttccccatcc tccgaaccat cctcgtcctc 7500
atcaccaatt actcgcagcc cggaaaactc ccgctgaaca tcctcaagat ttgcgtcctg 7560
agcctcaagc caggcctcaa attcctcgtc cccctttttg ctggacggta gggatgggga 7620
ttctcgggac ccctcctctt cctcttcaag gtcaccagac agagatgcta ctggggcaac 7680
ggaagaaaag ctgggtgcgg cctgtgagga tcagcttatc gatgataagc tgtcaaacat 7740
gagaattctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg 7800
ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct 7860
atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 7920
taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc 7980
cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg 8040
aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc 8100
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact 8160
tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc 8220
ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag 8280
catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat 8340
aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt 8400
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa 8460
gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc 8520
aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg 8580
gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt 8640
gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca 8700
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat 8760
gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca 8820
gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg 8880
atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg 8940
ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt 9000
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg 9060
ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata 9120
ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca 9180
ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag 9240
tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc 9300
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga 9360
tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg 9420
tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac 9480
gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg 9540
tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg 9600
ttcctggcct tttgctggcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac 9660
agcatggcct gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg 9720
aaggccatcc agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccccg 9780
agatgcgccg cgtgcggctg ctggagatgg cggacgcgat ggatatgttc tgccaagggt 9840
tggtttgcgc attcacagtt ctccgcaaga attgattggc tccaattctt ggagtggtga 9900
atccgttagc gaggtgccgc cctgcttcat ccccgtggcc cgttgctcgc gtttgctggc 9960
ggtgtccccg gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc 10020
cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag 10080
gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga 10140
cccgcttaac agcgtcaaca gcgtgccgca gatcccgggg ggcaatgaga tatgaaaaag 10200
cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc 10260
gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg 10320
cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga tcgttatgtt 10380
tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat tggggaattc 10440
agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg 10500
cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct 10560
gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa 10620
tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta tcactggcaa 10680
actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt 10740
tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg ctccaacaat 10800
gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc gatgttcggg 10860
gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc ttgtatggag 10920
cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc gcggctccgg 10980
gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga cggcaatttc 11040
gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg agccgggact 11100
gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa 11160
gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cggatcggga gatgggggag 11220
gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga cggcaataaa 11280
aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg gttcggtccc 11340
agggctggca ctctgtcgat accccaccga gaccccattg gggccaatac gcccgcgttt 11400
cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc gcagccaacg 11460
tcggggcggc aggccctgcc atagccactg gccccgtggg ttagggacgg ggtcccccat 11520
ggggaatggt ttatggttcg tgggggttat tattttgggc gttgcgtggg gtcaggtcca 11580
cgactggact gagcagacag acccatggtt tttggatggc ctgggcatgg accgcatgta 11640
ctggcgcgac acgaacaccg ggcgtctgtg gctgccaaac acccccgacc cccaaaaacc 11700
accgcgcgga tttctggcgt gccaagctag tcgaccaatt ctcatgtttg acagcttatc 11760
atcgcagatc cgggcaacgt tgttgccatt gctgcaggcg cagaactggt aggtatggaa 11820
gatctataca ttgaatcaat attggcaatt agccatatta gtcattggtt atatagcata 11880
aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta 11940
tattggctca tgtccaatat gaccgccat                                   11969



<210> 176
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3216).
      

<400> 176
tcctactcct gcgagcactt ccgctggggc aagtgcgtgg gatccggtgg aggctccggt 60
accttagtcg ccgtctcctc agagcccaaa tctgccgaca aaactcacgc ctgcccaccg 120
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa    777

<210> 177
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3216).

<400> 177
Ser Tyr Ser Cys Glu His Phe Arg Trp Gly Lys Cys Val Gly Ser Gly
 1               5                  10                  15      
Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro Lys Ser Ala
            20                  25                  30          
Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Pro Gly Lys
            


<210> 178
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3216).

<400> 178
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactcctgcg agcacttccg ctggggcaag tgcgtgggat ccggtggagg ctccggtacc 120
ttagtcgccg tctcctcaga gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc 180
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 240
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 300
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 360
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 420
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 480
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 540
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 600
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 660
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 720
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 780
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       834

<210> 179
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3216).

<400> 179
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Cys Glu His Phe Arg Trp Gly Lys Cys Val
            20                  25                  30          
Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro
        35                  40                  45              
Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu
    50                  55                  60                  
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
65                  70                  75                  80  
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                85                  90                  95      
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            100                 105                 110         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        115                 120                 125             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    130                 135                 140                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
145                 150                 155                 160 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                165                 170                 175     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            180                 185                 190         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        195                 200                 205             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    210                 215                 220                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
225                 230                 235                 240 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                245                 250                 255     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            260                 265                 270         
Ser Leu Ser Pro Gly Lys
        275             


<210> 180
<211> 11969
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3216).

<400> 180
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactcctgcg agcacttccg 1680
ctggggcaag tgcgtgggat ccggtggagg ctccggtacc ttagtcgccg tctcctcaga 1740
gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc ccagcacctg aactcctggg 1800
gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac 1860
ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa 1920
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta 1980
caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg 2040
caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat 2100
ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga 2160
tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga 2220
catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc 2280
cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag 2340
gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta 2400
cacgcagaag agcctctccc tgtctccggg taaatgaggg cccgtttaaa cagatccaga 2460
catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg 2520
ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa 2580
acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga 2640
ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg atccggctgc 2700
ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc 2760
acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcaggcgtc agcgggtgtt 2820
ggcgggtgtc ggggcgcagc catgaggtcg actctagagg atcgatgccc cgccccggac 2880
gaactaaacc tgactacgac atctctgccc cttcttcgcg gggcagtgca tgtaatccct 2940
tcagttggtt ggtacaactt gccaactggg ccctgttcca catgtgacac ggggggggac 3000
caaacacaaa ggggttctct gactgtagtt gacatcctta taaatggatg tgcacatttg 3060
ccaacactga gtggctttca tcctggagca gactttgcag tctgtggact gcaacacaac 3120
attgccttta tgtgtaactc ttggctgaag ctcttacacc aatgctgggg gacatgtacc 3180
tcccaggggc ccaggaagac tacgggaggc tacaccaacg tcaatcagag gggcctgtgt 3240
agctaccgat aagcggaccc tcaagagggc attagcaata gtgtttataa ggcccccttg 3300
ttaaccctaa acgggtagca tatgcttccc gggtagtagt atatactatc cagactaacc 3360
ctaattcaat agcatatgtt acccaacggg aagcatatgc tatcgaatta gggttagtaa 3420
aagggtccta aggaacagcg atatctccca ccccatgagc tgtcacggtt ttatttacat 3480
ggggtcagga ttccacgagg gtagtgaacc attttagtca caagggcagt ggctgaagat 3540
caaggagcgg gcagtgaact ctcctgaatc ttcgcctgct tcttcattct ccttcgttta 3600
gctaatagaa taactgctga gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa 3660
ggtttcaggt gacgccccca gaataaaatt tggacggggg gttcagtggt ggcattgtgc 3720
tatgacacca atataaccct cacaaacccc ttgggcaata aatactagtg taggaatgaa 3780
acattctgaa tatctttaac aatagaaatc catggggtgg ggacaagccg taaagactgg 3840
atgtccatct cacacgaatt tatggctatg ggcaacacat aatcctagtg caatatgata 3900
ctggggttat taagatgtgt cccaggcagg gaccaagaca ggtgaaccat gttgttacac 3960
tctatttgta acaaggggaa agagagtgga cgccgacagc agcggactcc actggttgtc 4020
tctaacaccc ccgaaaatta aacggggctc cacgccaatg gggcccataa acaaagacaa 4080
gtggccactc ttttttttga aattgtggag tgggggcacg cgtcagcccc cacacgccgc 4140
cctgcggttt tggactgtaa aataagggtg taataacttg gctgattgta accccgctaa 4200
ccactgcggt caaaccactt gcccacaaaa ccactaatgg caccccgggg aatacctgca 4260
taagtaggtg ggcgggccaa gataggggcg cgattgctgc gatctggagg acaaattaca 4320
cacacttgcg cctgagcgcc aagcacaggg ttgttggtcc tcatattcac gaggtcgctg 4380
agagcacggt gggctaatgt tgccatgggt agcatatact acccaaatat ctggatagca 4440
tatgctatcc taatctatat ctgggtagca taggctatcc taatctatat ctgggtagca 4500
tatgctatcc taatctatat ctgggtagta tatgctatcc taatttatat ctgggtagca 4560
taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta 4620
tatgctatcc taatctgtat ccgggtagca tatgctatcc taatagagat tagggtagta 4680
tatgctatcc taatttatat ctgggtagca tatactaccc aaatatctgg atagcatatg 4740
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagcatagg 4800
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg 4860
ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg 4920
ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg gtagcatatg 4980
ctatcctcat gcatatacag tcagcatatg atacccagta gtagagtggg agtgctatcc 5040
tttgcatatg ccgccacctc ccaagggggc gtgaattttc gctgcttgtc cttttcctgc 5100
tggttgctcc cattcttagg tgaatttaag gaggccaggc taaagccgtc gcatgtctga 5160
ttgctcacca ggtaaatgtc gctaatgttt tccaacgcga gaaggtgttg agcgcggagc 5220
tgagtgacgt gacaacatgg gtatgcccaa ttgccccatg ttgggaggac gaaaatggtg 5280
acaagacaga tggccagaaa tacaccaaca gcacgcatga tgtctactgg ggatttattc 5340
tttagtgcgg gggaatacac ggcttttaat acgattgagg gcgtctccta acaagttaca 5400
tcactcctgc ccttcctcac cctcatctcc atcacctcct tcatctccgt catctccgtc 5460
atcaccctcc gcggcagccc cttccaccat aggtggaaac cagggaggca aatctactcc 5520
atcgtcaaag ctgcacacag tcaccctgat attgcaggta ggagcgggct ttgtcataac 5580
aaggtcctta atcgcatcct tcaaaacctc agcaaatata tgagtttgta aaaagaccat 5640
gaaataacag acaatggact cccttagcgg gccaggttgt gggccgggtc caggggccat 5700
tccaaagggg agacgactca atggtgtaag acgacattgt ggaatagcaa gggcagttcc 5760
tcgccttagg ttgtaaaggg aggtcttact acctccatat acgaacacac cggcgaccca 5820
agttccttcg tcggtagtcc tttctacgtg actcctagcc aggagagctc ttaaaccttc 5880
tgcaatgttc tcaaatttcg ggttggaacc tccttgacca cgatgctttt ccaaaccacc 5940
ctcctttttt gcgccctgcc tccatcaccc tgaccccggg gtccagtgct tgggccttct 6000
cctgggtcat ctgcggggcc ctgctctatc gctcccgggg gcacgtcagg ctcaccatct 6060
gggccacctt cttggtggta ttcaaaataa tcggcttccc ctacagggtg gaaaaatggc 6120
cttctacctg gagggggcct gcgcggtgga gacccggatg atgatgactg actactggga 6180
ctcctgggcc tcttttctcc acgtccacga cctctccccc tggctctttc acgacttccc 6240
cccctggctc tttcacgtcc tctaccccgg cggcctccac tacctcctcg accccggcct 6300
ccactacctc ctcgaccccg gcctccactg cctcctcgac cccggcctcc acctcctgct 6360
cctgcccctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgctcct 6420
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6480
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6540
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6600
cctgctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc ccctcctgcc 6660
cctcctcctg ctcctgcccc tcctgctcct gcccctcctg cccctcctgc ccctcctgct 6720
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6780
cctcctgccc ctcctcctgc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6840
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6900
cctgcccctc ctgcccctcc tgcccctcct cctgctcctg cccctcctcc tgctcctgcc 6960
cctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 7020
gcccctcctg ctcctgcccc tcccgctcct gctcctgctc ctgttccacc gtgggtccct 7080
ttgcagccaa tgcaacttgg acgtttttgg ggtctccgga caccatctct atgtcttggc 7140
cctgatcctg agccgcccgg ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc 7200
cgtcctcgtc catggttatc accccctctt ctttgaggtc cactgccgcc ggagccttct 7260
ggtccagatg tgtctccctt ctctcctagg ccatttccag gtcctgtacc tggcccctcg 7320
tcagacatga ttcacactaa aagagatcaa tagacatctt tattagacga cgctcagtga 7380
atacagggag tgcagactcc tgccccctcc aacagccccc ccaccctcat ccccttcatg 7440
gtcgctgtca gacagatcca ggtctgaaaa ttccccatcc tccgaaccat cctcgtcctc 7500
atcaccaatt actcgcagcc cggaaaactc ccgctgaaca tcctcaagat ttgcgtcctg 7560
agcctcaagc caggcctcaa attcctcgtc cccctttttg ctggacggta gggatgggga 7620
ttctcgggac ccctcctctt cctcttcaag gtcaccagac agagatgcta ctggggcaac 7680
ggaagaaaag ctgggtgcgg cctgtgagga tcagcttatc gatgataagc tgtcaaacat 7740
gagaattctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg 7800
ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct 7860
atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 7920
taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc 7980
cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg 8040
aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc 8100
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact 8160
tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc 8220
ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag 8280
catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat 8340
aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt 8400
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa 8460
gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc 8520
aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg 8580
gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt 8640
gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca 8700
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat 8760
gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca 8820
gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg 8880
atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg 8940
ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt 9000
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg 9060
ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata 9120
ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca 9180
ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag 9240
tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc 9300
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga 9360
tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg 9420
tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac 9480
gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg 9540
tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg 9600
ttcctggcct tttgctggcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac 9660
agcatggcct gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg 9720
aaggccatcc agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccccg 9780
agatgcgccg cgtgcggctg ctggagatgg cggacgcgat ggatatgttc tgccaagggt 9840
tggtttgcgc attcacagtt ctccgcaaga attgattggc tccaattctt ggagtggtga 9900
atccgttagc gaggtgccgc cctgcttcat ccccgtggcc cgttgctcgc gtttgctggc 9960
ggtgtccccg gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc 10020
cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag 10080
gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga 10140
cccgcttaac agcgtcaaca gcgtgccgca gatcccgggg ggcaatgaga tatgaaaaag 10200
cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc 10260
gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg 10320
cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga tcgttatgtt 10380
tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat tggggaattc 10440
agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg 10500
cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct 10560
gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa 10620
tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta tcactggcaa 10680
actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt 10740
tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg ctccaacaat 10800
gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc gatgttcggg 10860
gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc ttgtatggag 10920
cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc gcggctccgg 10980
gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga cggcaatttc 11040
gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg agccgggact 11100
gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa 11160
gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cggatcggga gatgggggag 11220
gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga cggcaataaa 11280
aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg gttcggtccc 11340
agggctggca ctctgtcgat accccaccga gaccccattg gggccaatac gcccgcgttt 11400
cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc gcagccaacg 11460
tcggggcggc aggccctgcc atagccactg gccccgtggg ttagggacgg ggtcccccat 11520
ggggaatggt ttatggttcg tgggggttat tattttgggc gttgcgtggg gtcaggtcca 11580
cgactggact gagcagacag acccatggtt tttggatggc ctgggcatgg accgcatgta 11640
ctggcgcgac acgaacaccg ggcgtctgtg gctgccaaac acccccgacc cccaaaaacc 11700
accgcgcgga tttctggcgt gccaagctag tcgaccaatt ctcatgtttg acagcttatc 11760
atcgcagatc cgggcaacgt tgttgccatt gctgcaggcg cagaactggt aggtatggaa 11820
gatctataca ttgaatcaat attggcaatt agccatatta gtcattggtt atatagcata 11880
aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta 11940
tattggctca tgtccaatat gaccgccat                                   11969



<210> 181
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3217).

<400> 181
tcctactcct gcgagcactt ccgctggggc aagccgtgcg gatccggtgg aggctccggt 60
accttagtcg ccgtctcctc agagcccaaa tctgccgaca aaactcacgc ctgcccaccg 120
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa    777

<210> 182
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3217).

<400> 182
Ser Tyr Ser Cys Glu His Phe Arg Trp Gly Lys Pro Cys Gly Ser Gly
 1               5                  10                  15      
Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro Lys Ser Ala
            20                  25                  30          
Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Pro Gly Lys
            


<210> 183
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3217).

<400> 183
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactcctgcg agcacttccg ctggggcaag ccgtgcggat ccggtggagg ctccggtacc 120
ttagtcgccg tctcctcaga gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc 180
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 240
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 300
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 360
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 420
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 480
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 540
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 600
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 660
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 720
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 780
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       834

<210> 184
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3217).

<400> 184
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Cys Glu His Phe Arg Trp Gly Lys Pro Cys
            20                  25                  30          
Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro
        35                  40                  45              
Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu
    50                  55                  60                  
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
65                  70                  75                  80  
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                85                  90                  95      
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            100                 105                 110         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        115                 120                 125             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    130                 135                 140                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
145                 150                 155                 160 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                165                 170                 175     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            180                 185                 190         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        195                 200                 205             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    210                 215                 220                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
225                 230                 235                 240 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                245                 250                 255     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            260                 265                 270         
Ser Leu Ser Pro Gly Lys
        275             


<210> 185
<211> 11969
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3217).

<400> 185
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactcctgcg agcacttccg 1680
ctggggcaag ccgtgcggat ccggtggagg ctccggtacc ttagtcgccg tctcctcaga 1740
gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc ccagcacctg aactcctggg 1800
gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac 1860
ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa 1920
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta 1980
caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg 2040
caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat 2100
ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga 2160
tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga 2220
catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc 2280
cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag 2340
gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta 2400
cacgcagaag agcctctccc tgtctccggg taaatgaggg cccgtttaaa cagatccaga 2460
catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg 2520
ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa 2580
acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga 2640
ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg atccggctgc 2700
ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc 2760
acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcaggcgtc agcgggtgtt 2820
ggcgggtgtc ggggcgcagc catgaggtcg actctagagg atcgatgccc cgccccggac 2880
gaactaaacc tgactacgac atctctgccc cttcttcgcg gggcagtgca tgtaatccct 2940
tcagttggtt ggtacaactt gccaactggg ccctgttcca catgtgacac ggggggggac 3000
caaacacaaa ggggttctct gactgtagtt gacatcctta taaatggatg tgcacatttg 3060
ccaacactga gtggctttca tcctggagca gactttgcag tctgtggact gcaacacaac 3120
attgccttta tgtgtaactc ttggctgaag ctcttacacc aatgctgggg gacatgtacc 3180
tcccaggggc ccaggaagac tacgggaggc tacaccaacg tcaatcagag gggcctgtgt 3240
agctaccgat aagcggaccc tcaagagggc attagcaata gtgtttataa ggcccccttg 3300
ttaaccctaa acgggtagca tatgcttccc gggtagtagt atatactatc cagactaacc 3360
ctaattcaat agcatatgtt acccaacggg aagcatatgc tatcgaatta gggttagtaa 3420
aagggtccta aggaacagcg atatctccca ccccatgagc tgtcacggtt ttatttacat 3480
ggggtcagga ttccacgagg gtagtgaacc attttagtca caagggcagt ggctgaagat 3540
caaggagcgg gcagtgaact ctcctgaatc ttcgcctgct tcttcattct ccttcgttta 3600
gctaatagaa taactgctga gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa 3660
ggtttcaggt gacgccccca gaataaaatt tggacggggg gttcagtggt ggcattgtgc 3720
tatgacacca atataaccct cacaaacccc ttgggcaata aatactagtg taggaatgaa 3780
acattctgaa tatctttaac aatagaaatc catggggtgg ggacaagccg taaagactgg 3840
atgtccatct cacacgaatt tatggctatg ggcaacacat aatcctagtg caatatgata 3900
ctggggttat taagatgtgt cccaggcagg gaccaagaca ggtgaaccat gttgttacac 3960
tctatttgta acaaggggaa agagagtgga cgccgacagc agcggactcc actggttgtc 4020
tctaacaccc ccgaaaatta aacggggctc cacgccaatg gggcccataa acaaagacaa 4080
gtggccactc ttttttttga aattgtggag tgggggcacg cgtcagcccc cacacgccgc 4140
cctgcggttt tggactgtaa aataagggtg taataacttg gctgattgta accccgctaa 4200
ccactgcggt caaaccactt gcccacaaaa ccactaatgg caccccgggg aatacctgca 4260
taagtaggtg ggcgggccaa gataggggcg cgattgctgc gatctggagg acaaattaca 4320
cacacttgcg cctgagcgcc aagcacaggg ttgttggtcc tcatattcac gaggtcgctg 4380
agagcacggt gggctaatgt tgccatgggt agcatatact acccaaatat ctggatagca 4440
tatgctatcc taatctatat ctgggtagca taggctatcc taatctatat ctgggtagca 4500
tatgctatcc taatctatat ctgggtagta tatgctatcc taatttatat ctgggtagca 4560
taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta 4620
tatgctatcc taatctgtat ccgggtagca tatgctatcc taatagagat tagggtagta 4680
tatgctatcc taatttatat ctgggtagca tatactaccc aaatatctgg atagcatatg 4740
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagcatagg 4800
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg 4860
ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg 4920
ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg gtagcatatg 4980
ctatcctcat gcatatacag tcagcatatg atacccagta gtagagtggg agtgctatcc 5040
tttgcatatg ccgccacctc ccaagggggc gtgaattttc gctgcttgtc cttttcctgc 5100
tggttgctcc cattcttagg tgaatttaag gaggccaggc taaagccgtc gcatgtctga 5160
ttgctcacca ggtaaatgtc gctaatgttt tccaacgcga gaaggtgttg agcgcggagc 5220
tgagtgacgt gacaacatgg gtatgcccaa ttgccccatg ttgggaggac gaaaatggtg 5280
acaagacaga tggccagaaa tacaccaaca gcacgcatga tgtctactgg ggatttattc 5340
tttagtgcgg gggaatacac ggcttttaat acgattgagg gcgtctccta acaagttaca 5400
tcactcctgc ccttcctcac cctcatctcc atcacctcct tcatctccgt catctccgtc 5460
atcaccctcc gcggcagccc cttccaccat aggtggaaac cagggaggca aatctactcc 5520
atcgtcaaag ctgcacacag tcaccctgat attgcaggta ggagcgggct ttgtcataac 5580
aaggtcctta atcgcatcct tcaaaacctc agcaaatata tgagtttgta aaaagaccat 5640
gaaataacag acaatggact cccttagcgg gccaggttgt gggccgggtc caggggccat 5700
tccaaagggg agacgactca atggtgtaag acgacattgt ggaatagcaa gggcagttcc 5760
tcgccttagg ttgtaaaggg aggtcttact acctccatat acgaacacac cggcgaccca 5820
agttccttcg tcggtagtcc tttctacgtg actcctagcc aggagagctc ttaaaccttc 5880
tgcaatgttc tcaaatttcg ggttggaacc tccttgacca cgatgctttt ccaaaccacc 5940
ctcctttttt gcgccctgcc tccatcaccc tgaccccggg gtccagtgct tgggccttct 6000
cctgggtcat ctgcggggcc ctgctctatc gctcccgggg gcacgtcagg ctcaccatct 6060
gggccacctt cttggtggta ttcaaaataa tcggcttccc ctacagggtg gaaaaatggc 6120
cttctacctg gagggggcct gcgcggtgga gacccggatg atgatgactg actactggga 6180
ctcctgggcc tcttttctcc acgtccacga cctctccccc tggctctttc acgacttccc 6240
cccctggctc tttcacgtcc tctaccccgg cggcctccac tacctcctcg accccggcct 6300
ccactacctc ctcgaccccg gcctccactg cctcctcgac cccggcctcc acctcctgct 6360
cctgcccctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgctcct 6420
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6480
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6540
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6600
cctgctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc ccctcctgcc 6660
cctcctcctg ctcctgcccc tcctgctcct gcccctcctg cccctcctgc ccctcctgct 6720
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6780
cctcctgccc ctcctcctgc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6840
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6900
cctgcccctc ctgcccctcc tgcccctcct cctgctcctg cccctcctcc tgctcctgcc 6960
cctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 7020
gcccctcctg ctcctgcccc tcccgctcct gctcctgctc ctgttccacc gtgggtccct 7080
ttgcagccaa tgcaacttgg acgtttttgg ggtctccgga caccatctct atgtcttggc 7140
cctgatcctg agccgcccgg ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc 7200
cgtcctcgtc catggttatc accccctctt ctttgaggtc cactgccgcc ggagccttct 7260
ggtccagatg tgtctccctt ctctcctagg ccatttccag gtcctgtacc tggcccctcg 7320
tcagacatga ttcacactaa aagagatcaa tagacatctt tattagacga cgctcagtga 7380
atacagggag tgcagactcc tgccccctcc aacagccccc ccaccctcat ccccttcatg 7440
gtcgctgtca gacagatcca ggtctgaaaa ttccccatcc tccgaaccat cctcgtcctc 7500
atcaccaatt actcgcagcc cggaaaactc ccgctgaaca tcctcaagat ttgcgtcctg 7560
agcctcaagc caggcctcaa attcctcgtc cccctttttg ctggacggta gggatgggga 7620
ttctcgggac ccctcctctt cctcttcaag gtcaccagac agagatgcta ctggggcaac 7680
ggaagaaaag ctgggtgcgg cctgtgagga tcagcttatc gatgataagc tgtcaaacat 7740
gagaattctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg 7800
ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct 7860
atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 7920
taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc 7980
cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg 8040
aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc 8100
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact 8160
tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc 8220
ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag 8280
catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat 8340
aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt 8400
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa 8460
gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc 8520
aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg 8580
gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt 8640
gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca 8700
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat 8760
gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca 8820
gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg 8880
atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg 8940
ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt 9000
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg 9060
ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata 9120
ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca 9180
ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag 9240
tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc 9300
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga 9360
tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg 9420
tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac 9480
gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg 9540
tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg 9600
ttcctggcct tttgctggcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac 9660
agcatggcct gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg 9720
aaggccatcc agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccccg 9780
agatgcgccg cgtgcggctg ctggagatgg cggacgcgat ggatatgttc tgccaagggt 9840
tggtttgcgc attcacagtt ctccgcaaga attgattggc tccaattctt ggagtggtga 9900
atccgttagc gaggtgccgc cctgcttcat ccccgtggcc cgttgctcgc gtttgctggc 9960
ggtgtccccg gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc 10020
cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag 10080
gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga 10140
cccgcttaac agcgtcaaca gcgtgccgca gatcccgggg ggcaatgaga tatgaaaaag 10200
cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc 10260
gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg 10320
cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga tcgttatgtt 10380
tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat tggggaattc 10440
agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg 10500
cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct 10560
gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa 10620
tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta tcactggcaa 10680
actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt 10740
tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg ctccaacaat 10800
gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc gatgttcggg 10860
gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc ttgtatggag 10920
cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc gcggctccgg 10980
gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga cggcaatttc 11040
gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg agccgggact 11100
gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa 11160
gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cggatcggga gatgggggag 11220
gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga cggcaataaa 11280
aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg gttcggtccc 11340
agggctggca ctctgtcgat accccaccga gaccccattg gggccaatac gcccgcgttt 11400
cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc gcagccaacg 11460
tcggggcggc aggccctgcc atagccactg gccccgtggg ttagggacgg ggtcccccat 11520
ggggaatggt ttatggttcg tgggggttat tattttgggc gttgcgtggg gtcaggtcca 11580
cgactggact gagcagacag acccatggtt tttggatggc ctgggcatgg accgcatgta 11640
ctggcgcgac acgaacaccg ggcgtctgtg gctgccaaac acccccgacc cccaaaaacc 11700
accgcgcgga tttctggcgt gccaagctag tcgaccaatt ctcatgtttg acagcttatc 11760
atcgcagatc cgggcaacgt tgttgccatt gctgcaggcg cagaactggt aggtatggaa 11820
gatctataca ttgaatcaat attggcaatt agccatatta gtcattggtt atatagcata 11880
aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta 11940
tattggctca tgtccaatat gaccgccat                                   11969



<210> 186
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3218).

<400> 186
tcctactgca tggagcactt ccgctggggc tgcccggtgg gatccggtgg aggctccggt 60
accttagtcg ccgtctcctc agagcccaaa tctgccgaca aaactcacgc ctgcccaccg 120
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa    777

<210> 187
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3218).

<400> 187
Ser Tyr Cys Met Glu His Phe Arg Trp Gly Cys Pro Val Gly Ser Gly
 1               5                  10                  15      
Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro Lys Ser Ala
            20                  25                  30          
Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Pro Gly Lys
            


<210> 188
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3218).

<400> 188
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactgcatgg agcacttccg ctggggctgc ccggtgggat ccggtggagg ctccggtacc 120
ttagtcgccg tctcctcaga gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc 180
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 240
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 300
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 360
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 420
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 480
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 540
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 600
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 660
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 720
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 780
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       834

<210> 189
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3218).

<400> 189
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Cys Met Glu His Phe Arg Trp Gly Cys Pro Val
            20                  25                  30          
Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro
        35                  40                  45              
Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu
    50                  55                  60                  
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
65                  70                  75                  80  
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                85                  90                  95      
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            100                 105                 110         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        115                 120                 125             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    130                 135                 140                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
145                 150                 155                 160 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                165                 170                 175     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            180                 185                 190         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        195                 200                 205             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    210                 215                 220                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
225                 230                 235                 240 

Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                245                 250                 255     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            260                 265                 270         
Ser Leu Ser Pro Gly Lys
        275             


<210> 190
<211> 11969
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3218).

<400> 190
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactgcatgg agcacttccg 1680
ctggggctgc ccggtgggat ccggtggagg ctccggtacc ttagtcgccg tctcctcaga 1740
gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc ccagcacctg aactcctggg 1800
gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac 1860
ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa 1920
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta 1980
caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg 2040
caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat 2100
ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga 2160
tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga 2220
catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc 2280
cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag 2340
gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta 2400
cacgcagaag agcctctccc tgtctccggg taaatgaggg cccgtttaaa cagatccaga 2460
catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg 2520
ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa 2580
acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga 2640
ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg atccggctgc 2700
ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc 2760
acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcaggcgtc agcgggtgtt 2820
ggcgggtgtc ggggcgcagc catgaggtcg actctagagg atcgatgccc cgccccggac 2880
gaactaaacc tgactacgac atctctgccc cttcttcgcg gggcagtgca tgtaatccct 2940
tcagttggtt ggtacaactt gccaactggg ccctgttcca catgtgacac ggggggggac 3000
caaacacaaa ggggttctct gactgtagtt gacatcctta taaatggatg tgcacatttg 3060
ccaacactga gtggctttca tcctggagca gactttgcag tctgtggact gcaacacaac 3120
attgccttta tgtgtaactc ttggctgaag ctcttacacc aatgctgggg gacatgtacc 3180
tcccaggggc ccaggaagac tacgggaggc tacaccaacg tcaatcagag gggcctgtgt 3240
agctaccgat aagcggaccc tcaagagggc attagcaata gtgtttataa ggcccccttg 3300
ttaaccctaa acgggtagca tatgcttccc gggtagtagt atatactatc cagactaacc 3360
ctaattcaat agcatatgtt acccaacggg aagcatatgc tatcgaatta gggttagtaa 3420
aagggtccta aggaacagcg atatctccca ccccatgagc tgtcacggtt ttatttacat 3480
ggggtcagga ttccacgagg gtagtgaacc attttagtca caagggcagt ggctgaagat 3540
caaggagcgg gcagtgaact ctcctgaatc ttcgcctgct tcttcattct ccttcgttta 3600
gctaatagaa taactgctga gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa 3660
ggtttcaggt gacgccccca gaataaaatt tggacggggg gttcagtggt ggcattgtgc 3720
tatgacacca atataaccct cacaaacccc ttgggcaata aatactagtg taggaatgaa 3780
acattctgaa tatctttaac aatagaaatc catggggtgg ggacaagccg taaagactgg 3840
atgtccatct cacacgaatt tatggctatg ggcaacacat aatcctagtg caatatgata 3900
ctggggttat taagatgtgt cccaggcagg gaccaagaca ggtgaaccat gttgttacac 3960
tctatttgta acaaggggaa agagagtgga cgccgacagc agcggactcc actggttgtc 4020
tctaacaccc ccgaaaatta aacggggctc cacgccaatg gggcccataa acaaagacaa 4080
gtggccactc ttttttttga aattgtggag tgggggcacg cgtcagcccc cacacgccgc 4140
cctgcggttt tggactgtaa aataagggtg taataacttg gctgattgta accccgctaa 4200
ccactgcggt caaaccactt gcccacaaaa ccactaatgg caccccgggg aatacctgca 4260
taagtaggtg ggcgggccaa gataggggcg cgattgctgc gatctggagg acaaattaca 4320
cacacttgcg cctgagcgcc aagcacaggg ttgttggtcc tcatattcac gaggtcgctg 4380
agagcacggt gggctaatgt tgccatgggt agcatatact acccaaatat ctggatagca 4440
tatgctatcc taatctatat ctgggtagca taggctatcc taatctatat ctgggtagca 4500
tatgctatcc taatctatat ctgggtagta tatgctatcc taatttatat ctgggtagca 4560
taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta 4620
tatgctatcc taatctgtat ccgggtagca tatgctatcc taatagagat tagggtagta 4680
tatgctatcc taatttatat ctgggtagca tatactaccc aaatatctgg atagcatatg 4740
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagcatagg 4800
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg 4860
ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg 4920
ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg gtagcatatg 4980
ctatcctcat gcatatacag tcagcatatg atacccagta gtagagtggg agtgctatcc 5040
tttgcatatg ccgccacctc ccaagggggc gtgaattttc gctgcttgtc cttttcctgc 5100
tggttgctcc cattcttagg tgaatttaag gaggccaggc taaagccgtc gcatgtctga 5160
ttgctcacca ggtaaatgtc gctaatgttt tccaacgcga gaaggtgttg agcgcggagc 5220
tgagtgacgt gacaacatgg gtatgcccaa ttgccccatg ttgggaggac gaaaatggtg 5280
acaagacaga tggccagaaa tacaccaaca gcacgcatga tgtctactgg ggatttattc 5340
tttagtgcgg gggaatacac ggcttttaat acgattgagg gcgtctccta acaagttaca 5400
tcactcctgc ccttcctcac cctcatctcc atcacctcct tcatctccgt catctccgtc 5460
atcaccctcc gcggcagccc cttccaccat aggtggaaac cagggaggca aatctactcc 5520
atcgtcaaag ctgcacacag tcaccctgat attgcaggta ggagcgggct ttgtcataac 5580
aaggtcctta atcgcatcct tcaaaacctc agcaaatata tgagtttgta aaaagaccat 5640
gaaataacag acaatggact cccttagcgg gccaggttgt gggccgggtc caggggccat 5700
tccaaagggg agacgactca atggtgtaag acgacattgt ggaatagcaa gggcagttcc 5760
tcgccttagg ttgtaaaggg aggtcttact acctccatat acgaacacac cggcgaccca 5820
agttccttcg tcggtagtcc tttctacgtg actcctagcc aggagagctc ttaaaccttc 5880
tgcaatgttc tcaaatttcg ggttggaacc tccttgacca cgatgctttt ccaaaccacc 5940
ctcctttttt gcgccctgcc tccatcaccc tgaccccggg gtccagtgct tgggccttct 6000
cctgggtcat ctgcggggcc ctgctctatc gctcccgggg gcacgtcagg ctcaccatct 6060
gggccacctt cttggtggta ttcaaaataa tcggcttccc ctacagggtg gaaaaatggc 6120
cttctacctg gagggggcct gcgcggtgga gacccggatg atgatgactg actactggga 6180
ctcctgggcc tcttttctcc acgtccacga cctctccccc tggctctttc acgacttccc 6240
cccctggctc tttcacgtcc tctaccccgg cggcctccac tacctcctcg accccggcct 6300
ccactacctc ctcgaccccg gcctccactg cctcctcgac cccggcctcc acctcctgct 6360
cctgcccctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgctcct 6420
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6480
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6540
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6600
cctgctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc ccctcctgcc 6660
cctcctcctg ctcctgcccc tcctgctcct gcccctcctg cccctcctgc ccctcctgct 6720
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6780
cctcctgccc ctcctcctgc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6840
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6900
cctgcccctc ctgcccctcc tgcccctcct cctgctcctg cccctcctcc tgctcctgcc 6960
cctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 7020
gcccctcctg ctcctgcccc tcccgctcct gctcctgctc ctgttccacc gtgggtccct 7080
ttgcagccaa tgcaacttgg acgtttttgg ggtctccgga caccatctct atgtcttggc 7140
cctgatcctg agccgcccgg ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc 7200
cgtcctcgtc catggttatc accccctctt ctttgaggtc cactgccgcc ggagccttct 7260
ggtccagatg tgtctccctt ctctcctagg ccatttccag gtcctgtacc tggcccctcg 7320
tcagacatga ttcacactaa aagagatcaa tagacatctt tattagacga cgctcagtga 7380
atacagggag tgcagactcc tgccccctcc aacagccccc ccaccctcat ccccttcatg 7440
gtcgctgtca gacagatcca ggtctgaaaa ttccccatcc tccgaaccat cctcgtcctc 7500
atcaccaatt actcgcagcc cggaaaactc ccgctgaaca tcctcaagat ttgcgtcctg 7560
agcctcaagc caggcctcaa attcctcgtc cccctttttg ctggacggta gggatgggga 7620
ttctcgggac ccctcctctt cctcttcaag gtcaccagac agagatgcta ctggggcaac 7680
ggaagaaaag ctgggtgcgg cctgtgagga tcagcttatc gatgataagc tgtcaaacat 7740
gagaattctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg 7800
ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct 7860
atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 7920
taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc 7980
cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg 8040
aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc 8100
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact 8160
tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc 8220
ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag 8280
catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat 8340
aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt 8400
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa 8460
gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc 8520
aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg 8580
gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt 8640
gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca 8700
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat 8760
gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca 8820
gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg 8880
atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg 8940
ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt 9000
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg 9060
ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata 9120
ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca 9180
ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag 9240
tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc 9300
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga 9360
tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg 9420
tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac 9480
gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg 9540
tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg 9600
ttcctggcct tttgctggcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac 9660
agcatggcct gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg 9720
aaggccatcc agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccccg 9780
agatgcgccg cgtgcggctg ctggagatgg cggacgcgat ggatatgttc tgccaagggt 9840
tggtttgcgc attcacagtt ctccgcaaga attgattggc tccaattctt ggagtggtga 9900
atccgttagc gaggtgccgc cctgcttcat ccccgtggcc cgttgctcgc gtttgctggc 9960
ggtgtccccg gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc 10020
cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag 10080
gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga 10140
cccgcttaac agcgtcaaca gcgtgccgca gatcccgggg ggcaatgaga tatgaaaaag 10200
cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc 10260
gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg 10320
cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga tcgttatgtt 10380
tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat tggggaattc 10440
agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg 10500
cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct 10560
gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa 10620
tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta tcactggcaa 10680
actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt 10740
tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg ctccaacaat 10800
gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc gatgttcggg 10860
gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc ttgtatggag 10920
cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc gcggctccgg 10980
gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga cggcaatttc 11040
gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg agccgggact 11100
gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa 11160
gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cggatcggga gatgggggag 11220
gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga cggcaataaa 11280
aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg gttcggtccc 11340
agggctggca ctctgtcgat accccaccga gaccccattg gggccaatac gcccgcgttt 11400
cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc gcagccaacg 11460
tcggggcggc aggccctgcc atagccactg gccccgtggg ttagggacgg ggtcccccat 11520
ggggaatggt ttatggttcg tgggggttat tattttgggc gttgcgtggg gtcaggtcca 11580
cgactggact gagcagacag acccatggtt tttggatggc ctgggcatgg accgcatgta 11640
ctggcgcgac acgaacaccg ggcgtctgtg gctgccaaac acccccgacc cccaaaaacc 11700
accgcgcgga tttctggcgt gccaagctag tcgaccaatt ctcatgtttg acagcttatc 11760
atcgcagatc cgggcaacgt tgttgccatt gctgcaggcg cagaactggt aggtatggaa 11820
gatctataca ttgaatcaat attggcaatt agccatatta gtcattggtt atatagcata 11880
aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta 11940
tattggctca tgtccaatat gaccgccat                                   11969



<210> 191
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3219).

<400> 191
tcctgctcca tggagcactt ccgctggggc tgcccggtgg gatccggtgg aggctccggt 60
accttagtcg ccgtctcctc agagcccaaa tctgccgaca aaactcacgc ctgcccaccg 120
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa    777

<210> 192
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3219).

<400> 192
Ser Cys Ser Met Glu His Phe Arg Trp Gly Cys Pro Val Gly Ser Gly
 1               5                  10                  15      
Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro Lys Ser Ala
            20                  25                  30          
Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Pro Gly Lys
            


<210> 193
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3219).

<400> 193
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tgctccatgg agcacttccg ctggggctgc ccggtgggat ccggtggagg ctccggtacc 120
ttagtcgccg tctcctcaga gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc 180
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 240
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 300
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 360
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 420
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 480
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 540
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 600
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 660
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 720
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 780
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       834

<210> 194
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3219).

<400> 194
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Cys Ser Met Glu His Phe Arg Trp Gly Cys Pro Val
            20                  25                  30          
Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro
        35                  40                  45              
Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu
    50                  55                  60                  
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
65                  70                  75                  80  
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                85                  90                  95      
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            100                 105                 110         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        115                 120                 125             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    130                 135                 140                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
145                 150                 155                 160 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                165                 170                 175     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            180                 185                 190         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        195                 200                 205             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    210                 215                 220                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
225                 230                 235                 240 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                245                 250                 255     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            260                 265                 270         
Ser Leu Ser Pro Gly Lys
        275             


<210> 195
<211> 11969
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3219).

<400> 195
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tgctccatgg agcacttccg 1680
ctggggctgc ccggtgggat ccggtggagg ctccggtacc ttagtcgccg tctcctcaga 1740
gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc ccagcacctg aactcctggg 1800
gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac 1860
ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa 1920
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta 1980
caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg 2040
caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat 2100
ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga 2160
tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga 2220
catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc 2280
cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag 2340
gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta 2400
cacgcagaag agcctctccc tgtctccggg taaatgaggg cccgtttaaa cagatccaga 2460
catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg 2520
ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa 2580
acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga 2640
ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg atccggctgc 2700
ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc 2760
acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcaggcgtc agcgggtgtt 2820
ggcgggtgtc ggggcgcagc catgaggtcg actctagagg atcgatgccc cgccccggac 2880
gaactaaacc tgactacgac atctctgccc cttcttcgcg gggcagtgca tgtaatccct 2940
tcagttggtt ggtacaactt gccaactggg ccctgttcca catgtgacac ggggggggac 3000
caaacacaaa ggggttctct gactgtagtt gacatcctta taaatggatg tgcacatttg 3060
ccaacactga gtggctttca tcctggagca gactttgcag tctgtggact gcaacacaac 3120
attgccttta tgtgtaactc ttggctgaag ctcttacacc aatgctgggg gacatgtacc 3180
tcccaggggc ccaggaagac tacgggaggc tacaccaacg tcaatcagag gggcctgtgt 3240
agctaccgat aagcggaccc tcaagagggc attagcaata gtgtttataa ggcccccttg 3300
ttaaccctaa acgggtagca tatgcttccc gggtagtagt atatactatc cagactaacc 3360
ctaattcaat agcatatgtt acccaacggg aagcatatgc tatcgaatta gggttagtaa 3420
aagggtccta aggaacagcg atatctccca ccccatgagc tgtcacggtt ttatttacat 3480
ggggtcagga ttccacgagg gtagtgaacc attttagtca caagggcagt ggctgaagat 3540
caaggagcgg gcagtgaact ctcctgaatc ttcgcctgct tcttcattct ccttcgttta 3600
gctaatagaa taactgctga gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa 3660
ggtttcaggt gacgccccca gaataaaatt tggacggggg gttcagtggt ggcattgtgc 3720
tatgacacca atataaccct cacaaacccc ttgggcaata aatactagtg taggaatgaa 3780
acattctgaa tatctttaac aatagaaatc catggggtgg ggacaagccg taaagactgg 3840
atgtccatct cacacgaatt tatggctatg ggcaacacat aatcctagtg caatatgata 3900
ctggggttat taagatgtgt cccaggcagg gaccaagaca ggtgaaccat gttgttacac 3960
tctatttgta acaaggggaa agagagtgga cgccgacagc agcggactcc actggttgtc 4020
tctaacaccc ccgaaaatta aacggggctc cacgccaatg gggcccataa acaaagacaa 4080
gtggccactc ttttttttga aattgtggag tgggggcacg cgtcagcccc cacacgccgc 4140
cctgcggttt tggactgtaa aataagggtg taataacttg gctgattgta accccgctaa 4200
ccactgcggt caaaccactt gcccacaaaa ccactaatgg caccccgggg aatacctgca 4260
taagtaggtg ggcgggccaa gataggggcg cgattgctgc gatctggagg acaaattaca 4320
cacacttgcg cctgagcgcc aagcacaggg ttgttggtcc tcatattcac gaggtcgctg 4380
agagcacggt gggctaatgt tgccatgggt agcatatact acccaaatat ctggatagca 4440
tatgctatcc taatctatat ctgggtagca taggctatcc taatctatat ctgggtagca 4500
tatgctatcc taatctatat ctgggtagta tatgctatcc taatttatat ctgggtagca 4560
taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta 4620
tatgctatcc taatctgtat ccgggtagca tatgctatcc taatagagat tagggtagta 4680
tatgctatcc taatttatat ctgggtagca tatactaccc aaatatctgg atagcatatg 4740
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagcatagg 4800
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg 4860
ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg 4920
ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg gtagcatatg 4980
ctatcctcat gcatatacag tcagcatatg atacccagta gtagagtggg agtgctatcc 5040
tttgcatatg ccgccacctc ccaagggggc gtgaattttc gctgcttgtc cttttcctgc 5100
tggttgctcc cattcttagg tgaatttaag gaggccaggc taaagccgtc gcatgtctga 5160
ttgctcacca ggtaaatgtc gctaatgttt tccaacgcga gaaggtgttg agcgcggagc 5220
tgagtgacgt gacaacatgg gtatgcccaa ttgccccatg ttgggaggac gaaaatggtg 5280
acaagacaga tggccagaaa tacaccaaca gcacgcatga tgtctactgg ggatttattc 5340
tttagtgcgg gggaatacac ggcttttaat acgattgagg gcgtctccta acaagttaca 5400
tcactcctgc ccttcctcac cctcatctcc atcacctcct tcatctccgt catctccgtc 5460
atcaccctcc gcggcagccc cttccaccat aggtggaaac cagggaggca aatctactcc 5520
atcgtcaaag ctgcacacag tcaccctgat attgcaggta ggagcgggct ttgtcataac 5580
aaggtcctta atcgcatcct tcaaaacctc agcaaatata tgagtttgta aaaagaccat 5640
gaaataacag acaatggact cccttagcgg gccaggttgt gggccgggtc caggggccat 5700
tccaaagggg agacgactca atggtgtaag acgacattgt ggaatagcaa gggcagttcc 5760
tcgccttagg ttgtaaaggg aggtcttact acctccatat acgaacacac cggcgaccca 5820
agttccttcg tcggtagtcc tttctacgtg actcctagcc aggagagctc ttaaaccttc 5880
tgcaatgttc tcaaatttcg ggttggaacc tccttgacca cgatgctttt ccaaaccacc 5940
ctcctttttt gcgccctgcc tccatcaccc tgaccccggg gtccagtgct tgggccttct 6000
cctgggtcat ctgcggggcc ctgctctatc gctcccgggg gcacgtcagg ctcaccatct 6060
gggccacctt cttggtggta ttcaaaataa tcggcttccc ctacagggtg gaaaaatggc 6120
cttctacctg gagggggcct gcgcggtgga gacccggatg atgatgactg actactggga 6180
ctcctgggcc tcttttctcc acgtccacga cctctccccc tggctctttc acgacttccc 6240
cccctggctc tttcacgtcc tctaccccgg cggcctccac tacctcctcg accccggcct 6300
ccactacctc ctcgaccccg gcctccactg cctcctcgac cccggcctcc acctcctgct 6360
cctgcccctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgctcct 6420
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6480
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6540
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6600
cctgctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc ccctcctgcc 6660
cctcctcctg ctcctgcccc tcctgctcct gcccctcctg cccctcctgc ccctcctgct 6720
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6780
cctcctgccc ctcctcctgc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6840
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6900
cctgcccctc ctgcccctcc tgcccctcct cctgctcctg cccctcctcc tgctcctgcc 6960
cctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 7020
gcccctcctg ctcctgcccc tcccgctcct gctcctgctc ctgttccacc gtgggtccct 7080
ttgcagccaa tgcaacttgg acgtttttgg ggtctccgga caccatctct atgtcttggc 7140
cctgatcctg agccgcccgg ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc 7200
cgtcctcgtc catggttatc accccctctt ctttgaggtc cactgccgcc ggagccttct 7260
ggtccagatg tgtctccctt ctctcctagg ccatttccag gtcctgtacc tggcccctcg 7320
tcagacatga ttcacactaa aagagatcaa tagacatctt tattagacga cgctcagtga 7380
atacagggag tgcagactcc tgccccctcc aacagccccc ccaccctcat ccccttcatg 7440
gtcgctgtca gacagatcca ggtctgaaaa ttccccatcc tccgaaccat cctcgtcctc 7500
atcaccaatt actcgcagcc cggaaaactc ccgctgaaca tcctcaagat ttgcgtcctg 7560
agcctcaagc caggcctcaa attcctcgtc cccctttttg ctggacggta gggatgggga 7620
ttctcgggac ccctcctctt cctcttcaag gtcaccagac agagatgcta ctggggcaac 7680
ggaagaaaag ctgggtgcgg cctgtgagga tcagcttatc gatgataagc tgtcaaacat 7740
gagaattctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg 7800
ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct 7860
atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 7920
taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc 7980
cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg 8040
aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc 8100
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact 8160
tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc 8220
ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag 8280
catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat 8340
aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt 8400
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa 8460
gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc 8520
aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg 8580
gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt 8640
gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca 8700
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat 8760
gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca 8820
gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg 8880
atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg 8940
ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt 9000
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg 9060
ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata 9120
ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca 9180
ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag 9240
tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc 9300
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga 9360
tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg 9420
tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac 9480
gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg 9540
tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg 9600
ttcctggcct tttgctggcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac 9660
agcatggcct gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg 9720
aaggccatcc agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccccg 9780
agatgcgccg cgtgcggctg ctggagatgg cggacgcgat ggatatgttc tgccaagggt 9840
tggtttgcgc attcacagtt ctccgcaaga attgattggc tccaattctt ggagtggtga 9900
atccgttagc gaggtgccgc cctgcttcat ccccgtggcc cgttgctcgc gtttgctggc 9960
ggtgtccccg gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc 10020
cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag 10080
gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga 10140
cccgcttaac agcgtcaaca gcgtgccgca gatcccgggg ggcaatgaga tatgaaaaag 10200
cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc 10260
gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg 10320
cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga tcgttatgtt 10380
tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat tggggaattc 10440
agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg 10500
cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct 10560
gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa 10620
tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta tcactggcaa 10680
actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt 10740
tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg ctccaacaat 10800
gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc gatgttcggg 10860
gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc ttgtatggag 10920
cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc gcggctccgg 10980
gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga cggcaatttc 11040
gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg agccgggact 11100
gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa 11160
gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cggatcggga gatgggggag 11220
gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga cggcaataaa 11280
aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg gttcggtccc 11340
agggctggca ctctgtcgat accccaccga gaccccattg gggccaatac gcccgcgttt 11400
cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc gcagccaacg 11460
tcggggcggc aggccctgcc atagccactg gccccgtggg ttagggacgg ggtcccccat 11520
ggggaatggt ttatggttcg tgggggttat tattttgggc gttgcgtggg gtcaggtcca 11580
cgactggact gagcagacag acccatggtt tttggatggc ctgggcatgg accgcatgta 11640
ctggcgcgac acgaacaccg ggcgtctgtg gctgccaaac acccccgacc cccaaaaacc 11700
accgcgcgga tttctggcgt gccaagctag tcgaccaatt ctcatgtttg acagcttatc 11760
atcgcagatc cgggcaacgt tgttgccatt gctgcaggcg cagaactggt aggtatggaa 11820
gatctataca ttgaatcaat attggcaatt agccatatta gtcattggtt atatagcata 11880
aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta 11940
tattggctca tgtccaatat gaccgccat                                   11969



<210> 196
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3162).

<400> 196
tgctactcca tggagcactt ccgctggggc tgcccggtgg gatccggtgg aggctccggt 60
accttagtcg ccgtctcctc agagcccaaa tctgccgaca aaactcacgc ctgcccaccg 120
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa    777

<210> 197
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3162).

<400> 197
Cys Tyr Ser Met Glu His Phe Arg Trp Gly Cys Pro Val Gly Ser Gly
 1               5                  10                  15      
Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro Lys Ser Ala
            20                  25                  30          
Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Pro Gly Lys
            


<210> 198
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3162).

<400> 198
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctgc 60
tactccatgg agcacttccg ctggggctgc ccggtgggat ccggtggagg ctccggtacc 120
ttagtcgccg tctcctcaga gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc 180
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 240
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 300
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 360
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 420
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 480
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 540
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 600
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 660
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 720
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 780
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       834

<210> 199
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3162).

<400> 199
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Cys Tyr Ser Met Glu His Phe Arg Trp Gly Cys Pro Val
            20                  25                  30          
Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro
        35                  40                  45              
Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu
    50                  55                  60                  
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
65                  70                  75                  80  
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                85                  90                  95      
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            100                 105                 110         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        115                 120                 125             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    130                 135                 140                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
145                 150                 155                 160 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                165                 170                 175     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            180                 185                 190         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        195                 200                 205             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    210                 215                 220                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
225                 230                 235                 240 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                245                 250                 255     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            260                 265                 270         
Ser Leu Ser Pro Gly Lys
        275             


<210> 200
<211> 11969
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3162).

<400> 200
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctgc tactccatgg agcacttccg 1680
ctggggctgc ccggtgggat ccggtggagg ctccggtacc ttagtcgccg tctcctcaga 1740
gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc ccagcacctg aactcctggg 1800
gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac 1860
ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa 1920
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta 1980
caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg 2040
caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat 2100
ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga 2160
tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga 2220
catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc 2280
cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag 2340
gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta 2400
cacgcagaag agcctctccc tgtctccggg taaatgaggg cccgtttaaa cagatccaga 2460
catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg 2520
ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa 2580
acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga 2640
ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg atccggctgc 2700
ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc 2760
acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcaggcgtc agcgggtgtt 2820
ggcgggtgtc ggggcgcagc catgaggtcg actctagagg atcgatgccc cgccccggac 2880
gaactaaacc tgactacgac atctctgccc cttcttcgcg gggcagtgca tgtaatccct 2940
tcagttggtt ggtacaactt gccaactggg ccctgttcca catgtgacac ggggggggac 3000
caaacacaaa ggggttctct gactgtagtt gacatcctta taaatggatg tgcacatttg 3060
ccaacactga gtggctttca tcctggagca gactttgcag tctgtggact gcaacacaac 3120
attgccttta tgtgtaactc ttggctgaag ctcttacacc aatgctgggg gacatgtacc 3180
tcccaggggc ccaggaagac tacgggaggc tacaccaacg tcaatcagag gggcctgtgt 3240
agctaccgat aagcggaccc tcaagagggc attagcaata gtgtttataa ggcccccttg 3300
ttaaccctaa acgggtagca tatgcttccc gggtagtagt atatactatc cagactaacc 3360
ctaattcaat agcatatgtt acccaacggg aagcatatgc tatcgaatta gggttagtaa 3420
aagggtccta aggaacagcg atatctccca ccccatgagc tgtcacggtt ttatttacat 3480
ggggtcagga ttccacgagg gtagtgaacc attttagtca caagggcagt ggctgaagat 3540
caaggagcgg gcagtgaact ctcctgaatc ttcgcctgct tcttcattct ccttcgttta 3600
gctaatagaa taactgctga gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa 3660
ggtttcaggt gacgccccca gaataaaatt tggacggggg gttcagtggt ggcattgtgc 3720
tatgacacca atataaccct cacaaacccc ttgggcaata aatactagtg taggaatgaa 3780
acattctgaa tatctttaac aatagaaatc catggggtgg ggacaagccg taaagactgg 3840
atgtccatct cacacgaatt tatggctatg ggcaacacat aatcctagtg caatatgata 3900
ctggggttat taagatgtgt cccaggcagg gaccaagaca ggtgaaccat gttgttacac 3960
tctatttgta acaaggggaa agagagtgga cgccgacagc agcggactcc actggttgtc 4020
tctaacaccc ccgaaaatta aacggggctc cacgccaatg gggcccataa acaaagacaa 4080
gtggccactc ttttttttga aattgtggag tgggggcacg cgtcagcccc cacacgccgc 4140
cctgcggttt tggactgtaa aataagggtg taataacttg gctgattgta accccgctaa 4200
ccactgcggt caaaccactt gcccacaaaa ccactaatgg caccccgggg aatacctgca 4260
taagtaggtg ggcgggccaa gataggggcg cgattgctgc gatctggagg acaaattaca 4320
cacacttgcg cctgagcgcc aagcacaggg ttgttggtcc tcatattcac gaggtcgctg 4380
agagcacggt gggctaatgt tgccatgggt agcatatact acccaaatat ctggatagca 4440
tatgctatcc taatctatat ctgggtagca taggctatcc taatctatat ctgggtagca 4500
tatgctatcc taatctatat ctgggtagta tatgctatcc taatttatat ctgggtagca 4560
taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta 4620
tatgctatcc taatctgtat ccgggtagca tatgctatcc taatagagat tagggtagta 4680
tatgctatcc taatttatat ctgggtagca tatactaccc aaatatctgg atagcatatg 4740
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagcatagg 4800
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg 4860
ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg 4920
ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg gtagcatatg 4980
ctatcctcat gcatatacag tcagcatatg atacccagta gtagagtggg agtgctatcc 5040
tttgcatatg ccgccacctc ccaagggggc gtgaattttc gctgcttgtc cttttcctgc 5100
tggttgctcc cattcttagg tgaatttaag gaggccaggc taaagccgtc gcatgtctga 5160
ttgctcacca ggtaaatgtc gctaatgttt tccaacgcga gaaggtgttg agcgcggagc 5220
tgagtgacgt gacaacatgg gtatgcccaa ttgccccatg ttgggaggac gaaaatggtg 5280
acaagacaga tggccagaaa tacaccaaca gcacgcatga tgtctactgg ggatttattc 5340
tttagtgcgg gggaatacac ggcttttaat acgattgagg gcgtctccta acaagttaca 5400
tcactcctgc ccttcctcac cctcatctcc atcacctcct tcatctccgt catctccgtc 5460
atcaccctcc gcggcagccc cttccaccat aggtggaaac cagggaggca aatctactcc 5520
atcgtcaaag ctgcacacag tcaccctgat attgcaggta ggagcgggct ttgtcataac 5580
aaggtcctta atcgcatcct tcaaaacctc agcaaatata tgagtttgta aaaagaccat 5640
gaaataacag acaatggact cccttagcgg gccaggttgt gggccgggtc caggggccat 5700
tccaaagggg agacgactca atggtgtaag acgacattgt ggaatagcaa gggcagttcc 5760
tcgccttagg ttgtaaaggg aggtcttact acctccatat acgaacacac cggcgaccca 5820
agttccttcg tcggtagtcc tttctacgtg actcctagcc aggagagctc ttaaaccttc 5880
tgcaatgttc tcaaatttcg ggttggaacc tccttgacca cgatgctttt ccaaaccacc 5940
ctcctttttt gcgccctgcc tccatcaccc tgaccccggg gtccagtgct tgggccttct 6000
cctgggtcat ctgcggggcc ctgctctatc gctcccgggg gcacgtcagg ctcaccatct 6060
gggccacctt cttggtggta ttcaaaataa tcggcttccc ctacagggtg gaaaaatggc 6120
cttctacctg gagggggcct gcgcggtgga gacccggatg atgatgactg actactggga 6180
ctcctgggcc tcttttctcc acgtccacga cctctccccc tggctctttc acgacttccc 6240
cccctggctc tttcacgtcc tctaccccgg cggcctccac tacctcctcg accccggcct 6300
ccactacctc ctcgaccccg gcctccactg cctcctcgac cccggcctcc acctcctgct 6360
cctgcccctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgctcct 6420
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6480
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6540
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6600
cctgctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc ccctcctgcc 6660
cctcctcctg ctcctgcccc tcctgctcct gcccctcctg cccctcctgc ccctcctgct 6720
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6780
cctcctgccc ctcctcctgc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6840
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6900
cctgcccctc ctgcccctcc tgcccctcct cctgctcctg cccctcctcc tgctcctgcc 6960
cctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 7020
gcccctcctg ctcctgcccc tcccgctcct gctcctgctc ctgttccacc gtgggtccct 7080
ttgcagccaa tgcaacttgg acgtttttgg ggtctccgga caccatctct atgtcttggc 7140
cctgatcctg agccgcccgg ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc 7200
cgtcctcgtc catggttatc accccctctt ctttgaggtc cactgccgcc ggagccttct 7260
ggtccagatg tgtctccctt ctctcctagg ccatttccag gtcctgtacc tggcccctcg 7320
tcagacatga ttcacactaa aagagatcaa tagacatctt tattagacga cgctcagtga 7380
atacagggag tgcagactcc tgccccctcc aacagccccc ccaccctcat ccccttcatg 7440
gtcgctgtca gacagatcca ggtctgaaaa ttccccatcc tccgaaccat cctcgtcctc 7500
atcaccaatt actcgcagcc cggaaaactc ccgctgaaca tcctcaagat ttgcgtcctg 7560
agcctcaagc caggcctcaa attcctcgtc cccctttttg ctggacggta gggatgggga 7620
ttctcgggac ccctcctctt cctcttcaag gtcaccagac agagatgcta ctggggcaac 7680
ggaagaaaag ctgggtgcgg cctgtgagga tcagcttatc gatgataagc tgtcaaacat 7740
gagaattctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg 7800
ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct 7860
atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 7920
taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc 7980
cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg 8040
aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc 8100
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact 8160
tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc 8220
ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag 8280
catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat 8340
aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt 8400
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa 8460
gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc 8520
aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg 8580
gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt 8640
gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca 8700
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat 8760
gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca 8820
gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg 8880
atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg 8940
ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt 9000
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg 9060
ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata 9120
ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca 9180
ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag 9240
tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc 9300
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga 9360
tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg 9420
tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac 9480
gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg 9540
tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg 9600
ttcctggcct tttgctggcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac 9660
agcatggcct gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg 9720
aaggccatcc agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccccg 9780
agatgcgccg cgtgcggctg ctggagatgg cggacgcgat ggatatgttc tgccaagggt 9840
tggtttgcgc attcacagtt ctccgcaaga attgattggc tccaattctt ggagtggtga 9900
atccgttagc gaggtgccgc cctgcttcat ccccgtggcc cgttgctcgc gtttgctggc 9960
ggtgtccccg gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc 10020
cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag 10080
gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga 10140
cccgcttaac agcgtcaaca gcgtgccgca gatcccgggg ggcaatgaga tatgaaaaag 10200
cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc 10260
gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg 10320
cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga tcgttatgtt 10380
tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat tggggaattc 10440
agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg 10500
cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct 10560
gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa 10620
tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta tcactggcaa 10680
actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt 10740
tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg ctccaacaat 10800
gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc gatgttcggg 10860
gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc ttgtatggag 10920
cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc gcggctccgg 10980
gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga cggcaatttc 11040
gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg agccgggact 11100
gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa 11160
gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cggatcggga gatgggggag 11220
gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga cggcaataaa 11280
aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg gttcggtccc 11340
agggctggca ctctgtcgat accccaccga gaccccattg gggccaatac gcccgcgttt 11400
cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc gcagccaacg 11460
tcggggcggc aggccctgcc atagccactg gccccgtggg ttagggacgg ggtcccccat 11520
ggggaatggt ttatggttcg tgggggttat tattttgggc gttgcgtggg gtcaggtcca 11580
cgactggact gagcagacag acccatggtt tttggatggc ctgggcatgg accgcatgta 11640
ctggcgcgac acgaacaccg ggcgtctgtg gctgccaaac acccccgacc cccaaaaacc 11700
accgcgcgga tttctggcgt gccaagctag tcgaccaatt ctcatgtttg acagcttatc 11760
atcgcagatc cgggcaacgt tgttgccatt gctgcaggcg cagaactggt aggtatggaa 11820
gatctataca ttgaatcaat attggcaatt agccatatta gtcattggtt atatagcata 11880
aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta 11940
tattggctca tgtccaatat gaccgccat                                   11969



<210> 201
<211> 720
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3250).

<400> 201
tcctactcct gcgagcactt ccgctggtgc aagccggtgg gaggaggcgg atcctgccca 60
ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 120
aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 180
cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 240
aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 300
gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 360
ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 420
gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc 480
ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg 540
gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac 600
agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg 660
atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tctgggtaaa 720


<210> 202
<211> 240
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3250).

<400> 202
Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly Gly Gly
 1               5                  10                  15      
Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
            20                  25                  30          
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
        35                  40                  45              
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
    50                  55                  60                  
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
65                  70                  75                  80  
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
                85                  90                  95      
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
            100                 105                 110         
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
        115                 120                 125             
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
    130                 135                 140                 
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
145                 150                 155                 160 
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
                165                 170                 175     
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
            180                 185                 190         
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
        195                 200                 205             
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
    210                 215                 220                 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
225                 230                 235                 240 


<210> 203
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3250).

<400> 203
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactcctgcg agcacttccg ctggtgcaag ccggtgggag gaggcggatc ctgcccaccg 120
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctct gggtaaa    777

<210> 204
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3250).

<400> 204
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val
            20                  25                  30          
Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Leu Gly Lys
            


<210> 205
<211> 11912
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3250).

<400> 205
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactcctgcg agcacttccg 1680
ctggtgcaag ccggtgggag gaggcggatc ctgcccaccg tgcccagcac ctgaactcct 1740
ggggggaccg tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg 1800
gacccctgag gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt 1860
caactggtac gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca 1920
gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa 1980
tggcaaggag tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac 2040
catctccaaa gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg 2100
ggatgagctg accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag 2160
cgacatcgcc gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc 2220
tcccgtgctg gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag 2280
caggtggcag caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca 2340
ctacacgcag aagagcctct ccctgtctct gggtaaatga gggcccgttt aaacagatcc 2400
agacatgata agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa 2460
atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa 2520
taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg 2580
ggaggttttt taaagcaagt aaaacctcta caaatgtggt atggctgatt atgatccggc 2640
tgcctcgcgc gtttcggtga tgacggtgaa aacctctgac acatgcagct cccggagacg 2700
gtcacagctt gtctgtaagc ggatgccggg agcagacaag cccgtcaggc gtcagcgggt 2760
gttggcgggt gtcggggcgc agccatgagg tcgactctag aggatcgatg ccccgccccg 2820
gacgaactaa acctgactac gacatctctg ccccttcttc gcggggcagt gcatgtaatc 2880
ccttcagttg gttggtacaa cttgccaact gggccctgtt ccacatgtga cacggggggg 2940
gaccaaacac aaaggggttc tctgactgta gttgacatcc ttataaatgg atgtgcacat 3000
ttgccaacac tgagtggctt tcatcctgga gcagactttg cagtctgtgg actgcaacac 3060
aacattgcct ttatgtgtaa ctcttggctg aagctcttac accaatgctg ggggacatgt 3120
acctcccagg ggcccaggaa gactacggga ggctacacca acgtcaatca gaggggcctg 3180
tgtagctacc gataagcgga ccctcaagag ggcattagca atagtgttta taaggccccc 3240
ttgttaaccc taaacgggta gcatatgctt cccgggtagt agtatatact atccagacta 3300
accctaattc aatagcatat gttacccaac gggaagcata tgctatcgaa ttagggttag 3360
taaaagggtc ctaaggaaca gcgatatctc ccaccccatg agctgtcacg gttttattta 3420
catggggtca ggattccacg agggtagtga accattttag tcacaagggc agtggctgaa 3480
gatcaaggag cgggcagtga actctcctga atcttcgcct gcttcttcat tctccttcgt 3540
ttagctaata gaataactgc tgagttgtga acagtaaggt gtatgtgagg tgctcgaaaa 3600
caaggtttca ggtgacgccc ccagaataaa atttggacgg ggggttcagt ggtggcattg 3660
tgctatgaca ccaatataac cctcacaaac cccttgggca ataaatacta gtgtaggaat 3720
gaaacattct gaatatcttt aacaatagaa atccatgggg tggggacaag ccgtaaagac 3780
tggatgtcca tctcacacga atttatggct atgggcaaca cataatccta gtgcaatatg 3840
atactggggt tattaagatg tgtcccaggc agggaccaag acaggtgaac catgttgtta 3900
cactctattt gtaacaaggg gaaagagagt ggacgccgac agcagcggac tccactggtt 3960
gtctctaaca cccccgaaaa ttaaacgggg ctccacgcca atggggccca taaacaaaga 4020
caagtggcca ctcttttttt tgaaattgtg gagtgggggc acgcgtcagc ccccacacgc 4080
cgccctgcgg ttttggactg taaaataagg gtgtaataac ttggctgatt gtaaccccgc 4140
taaccactgc ggtcaaacca cttgcccaca aaaccactaa tggcaccccg gggaatacct 4200
gcataagtag gtgggcgggc caagataggg gcgcgattgc tgcgatctgg aggacaaatt 4260
acacacactt gcgcctgagc gccaagcaca gggttgttgg tcctcatatt cacgaggtcg 4320
ctgagagcac ggtgggctaa tgttgccatg ggtagcatat actacccaaa tatctggata 4380
gcatatgcta tcctaatcta tatctgggta gcataggcta tcctaatcta tatctgggta 4440
gcatatgcta tcctaatcta tatctgggta gtatatgcta tcctaattta tatctgggta 4500
gcataggcta tcctaatcta tatctgggta gcatatgcta tcctaatcta tatctgggta 4560
gtatatgcta tcctaatctg tatccgggta gcatatgcta tcctaataga gattagggta 4620
gtatatgcta tcctaattta tatctgggta gcatatacta cccaaatatc tggatagcat 4680
atgctatcct aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagcat 4740
aggctatcct aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagtat 4800
atgctatcct aatttatatc tgggtagcat aggctatcct aatctatatc tgggtagcat 4860
atgctatcct aatctatatc tgggtagtat atgctatcct aatctgtatc cgggtagcat 4920
atgctatcct catgcatata cagtcagcat atgataccca gtagtagagt gggagtgcta 4980
tcctttgcat atgccgccac ctcccaaggg ggcgtgaatt ttcgctgctt gtccttttcc 5040
tgctggttgc tcccattctt aggtgaattt aaggaggcca ggctaaagcc gtcgcatgtc 5100
tgattgctca ccaggtaaat gtcgctaatg ttttccaacg cgagaaggtg ttgagcgcgg 5160
agctgagtga cgtgacaaca tgggtatgcc caattgcccc atgttgggag gacgaaaatg 5220
gtgacaagac agatggccag aaatacacca acagcacgca tgatgtctac tggggattta 5280
ttctttagtg cgggggaata cacggctttt aatacgattg agggcgtctc ctaacaagtt 5340
acatcactcc tgcccttcct caccctcatc tccatcacct ccttcatctc cgtcatctcc 5400
gtcatcaccc tccgcggcag ccccttccac cataggtgga aaccagggag gcaaatctac 5460
tccatcgtca aagctgcaca cagtcaccct gatattgcag gtaggagcgg gctttgtcat 5520
aacaaggtcc ttaatcgcat ccttcaaaac ctcagcaaat atatgagttt gtaaaaagac 5580
catgaaataa cagacaatgg actcccttag cgggccaggt tgtgggccgg gtccaggggc 5640
cattccaaag gggagacgac tcaatggtgt aagacgacat tgtggaatag caagggcagt 5700
tcctcgcctt aggttgtaaa gggaggtctt actacctcca tatacgaaca caccggcgac 5760
ccaagttcct tcgtcggtag tcctttctac gtgactccta gccaggagag ctcttaaacc 5820
ttctgcaatg ttctcaaatt tcgggttgga acctccttga ccacgatgct tttccaaacc 5880
accctccttt tttgcgccct gcctccatca ccctgacccc ggggtccagt gcttgggcct 5940
tctcctgggt catctgcggg gccctgctct atcgctcccg ggggcacgtc aggctcacca 6000
tctgggccac cttcttggtg gtattcaaaa taatcggctt cccctacagg gtggaaaaat 6060
ggccttctac ctggaggggg cctgcgcggt ggagacccgg atgatgatga ctgactactg 6120
ggactcctgg gcctcttttc tccacgtcca cgacctctcc ccctggctct ttcacgactt 6180
ccccccctgg ctctttcacg tcctctaccc cggcggcctc cactacctcc tcgaccccgg 6240
cctccactac ctcctcgacc ccggcctcca ctgcctcctc gaccccggcc tccacctcct 6300
gctcctgccc ctcctgctcc tgcccctcct cctgctcctg cccctcctgc ccctcctgct 6360
cctgcccctc ctgcccctcc tgctcctgcc cctcctgccc ctcctgctcc tgcccctcct 6420
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctgcccct 6480
cctgctcctg cccctcctgc ccctcctgct cctgcccctc ctgcccctcc tgctcctgcc 6540
cctcctgctc ctgcccctcc tgctcctgcc cctcctgctc ctgcccctcc tgcccctcct 6600
gcccctcctc ctgctcctgc ccctcctgct cctgcccctc ctgcccctcc tgcccctcct 6660
gctcctgccc ctcctcctgc tcctgcccct cctgcccctc ctgcccctcc tcctgctcct 6720
gcccctcctg cccctcctcc tgctcctgcc cctcctcctg ctcctgcccc tcctgcccct 6780
cctgcccctc ctcctgctcc tgcccctcct gcccctcctc ctgctcctgc ccctcctcct 6840
gctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 6900
gcccctcctg cccctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6960
cctgcccctc ctgctcctgc ccctcccgct cctgctcctg ctcctgttcc accgtgggtc 7020
cctttgcagc caatgcaact tggacgtttt tggggtctcc ggacaccatc tctatgtctt 7080
ggccctgatc ctgagccgcc cggggctcct ggtcttccgc ctcctcgtcc tcgtcctctt 7140
ccccgtcctc gtccatggtt atcaccccct cttctttgag gtccactgcc gccggagcct 7200
tctggtccag atgtgtctcc cttctctcct aggccatttc caggtcctgt acctggcccc 7260
tcgtcagaca tgattcacac taaaagagat caatagacat ctttattaga cgacgctcag 7320
tgaatacagg gagtgcagac tcctgccccc tccaacagcc cccccaccct catccccttc 7380
atggtcgctg tcagacagat ccaggtctga aaattcccca tcctccgaac catcctcgtc 7440
ctcatcacca attactcgca gcccggaaaa ctcccgctga acatcctcaa gatttgcgtc 7500
ctgagcctca agccaggcct caaattcctc gtcccccttt ttgctggacg gtagggatgg 7560
ggattctcgg gacccctcct cttcctcttc aaggtcacca gacagagatg ctactggggc 7620
aacggaagaa aagctgggtg cggcctgtga ggatcagctt atcgatgata agctgtcaaa 7680
catgagaatt cttgaagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc 7740
atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc 7800
cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc 7860
tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc 7920
gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg 7980
gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat 8040
ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc 8100
acttttaaag ttctgctatg tggcgcggta ttatcccgtg ttgacgccgg gcaagagcaa 8160
ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa 8220
aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt 8280
gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct 8340
tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat 8400
gaagccatac caaacgacga gcgtgacacc acgatgcctg cagcaatggc aacaacgttg 8460
cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg 8520
atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt 8580
attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg 8640
ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg 8700
gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg 8760
tcagaccaag tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa 8820
aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt 8880
tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt 8940
tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt 9000
ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag 9060
ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa gaactctgta 9120
gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat 9180
aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg 9240
ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg 9300
agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac 9360
aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga 9420
aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt 9480
ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta 9540
cggttcctgg ccttttgctg gccttgaagc tgtccctgat ggtcgtcatc tacctgcctg 9600
gacagcatgg cctgcaacgc gggcatcccg atgccgccgg aagcgagaag aatcataatg 9660
gggaaggcca tccagcctcg cgtcgcgaac gccagcaaga cgtagcccag cgcgtcggcc 9720
ccgagatgcg ccgcgtgcgg ctgctggaga tggcggacgc gatggatatg ttctgccaag 9780
ggttggtttg cgcattcaca gttctccgca agaattgatt ggctccaatt cttggagtgg 9840
tgaatccgtt agcgaggtgc cgccctgctt catccccgtg gcccgttgct cgcgtttgct 9900
ggcggtgtcc ccggaagaaa tatatttgca tgtctttagt tctatgatga cacaaacccc 9960
gcccagcgtc ttgtcattgg cgaattcgaa cacgcagatg cagtcggggc ggcgcggtcc 10020
gaggtccact tcgcatatta aggtgacgcg tgtggcctcg aacaccgagc gaccctgcag 10080
cgacccgctt aacagcgtca acagcgtgcc gcagatcccg gggggcaatg agatatgaaa 10140
aagcctgaac tcaccgcgac gtctgtcgag aagtttctga tcgaaaagtt cgacagcgtc 10200
tccgacctga tgcagctctc ggagggcgaa gaatctcgtg ctttcagctt cgatgtagga 10260
gggcgtggat atgtcctgcg ggtaaatagc tgcgccgatg gtttctacaa agatcgttat 10320
gtttatcggc actttgcatc ggccgcgctc ccgattccgg aagtgcttga cattggggaa 10380
ttcagcgaga gcctgaccta ttgcatctcc cgccgtgcac agggtgtcac gttgcaagac 10440
ctgcctgaaa ccgaactgcc cgctgttctg cagccggtcg cggaggccat ggatgcgatc 10500
gctgcggccg atcttagcca gacgagcggg ttcggcccat tcggaccgca aggaatcggt 10560
caatacacta catggcgtga tttcatatgc gcgattgctg atccccatgt gtatcactgg 10620
caaactgtga tggacgacac cgtcagtgcg tccgtcgcgc aggctctcga tgagctgatg 10680
ctttgggccg aggactgccc cgaagtccgg cacctcgtgc acgcggattt cggctccaac 10740
aatgtcctga cggacaatgg ccgcataaca gcggtcattg actggagcga ggcgatgttc 10800
ggggattccc aatacgaggt cgccaacatc ttcttctgga ggccgtggtt ggcttgtatg 10860
gagcagcaga cgcgctactt cgagcggagg catccggagc ttgcaggatc gccgcggctc 10920
cgggcgtata tgctccgcat tggtcttgac caactctatc agagcttggt tgacggcaat 10980
ttcgatgatg cagcttgggc gcagggtcga tgcgacgcaa tcgtccgatc cggagccggg 11040
actgtcgggc gtacacaaat cgcccgcaga agcgcggccg tctggaccga tggctgtgta 11100
gaagtactcg ccgatagtgg aaaccgacgc cccagcactc gtccggatcg ggagatgggg 11160
gaggctaact gaaacacgga aggagacaat accggaagga acccgcgcta tgacggcaat 11220
aaaaagacag aataaaacgc acgggtgttg ggtcgtttgt tcataaacgc ggggttcggt 11280
cccagggctg gcactctgtc gataccccac cgagacccca ttggggccaa tacgcccgcg 11340
tttcttcctt ttccccaccc caccccccaa gttcgggtga aggcccaggg ctcgcagcca 11400
acgtcggggc ggcaggccct gccatagcca ctggccccgt gggttaggga cggggtcccc 11460
catggggaat ggtttatggt tcgtgggggt tattattttg ggcgttgcgt ggggtcaggt 11520
ccacgactgg actgagcaga cagacccatg gtttttggat ggcctgggca tggaccgcat 11580
gtactggcgc gacacgaaca ccgggcgtct gtggctgcca aacacccccg acccccaaaa 11640
accaccgcgc ggatttctgg cgtgccaagc tagtcgacca attctcatgt ttgacagctt 11700
atcatcgcag atccgggcaa cgttgttgcc attgctgcag gcgcagaact ggtaggtatg 11760
gaagatctat acattgaatc aatattggca attagccata ttagtcattg gttatatagc 11820
ataaatcaat attggctatt ggccattgca tacgttgtat ctatatcata atatgtacat 11880
ttatattggc tcatgtccaa tatgaccgcc at                               11912



<210> 206
<211> 735
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3251).

<400> 206
tcctactcct gcgagcactt ccgctggtgc aagccggtgg gaggcggagg aagcggcgga 60
ggcggatcct gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc 120
ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg 180
gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg 240
gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg 300
gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag 360
gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag 420
ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag 480
gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag 540
agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc 600
tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc 660
ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc 720
ctgtctctgg gtaaa                                                  735

<210> 207
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3251).

<400> 207
Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly Gly Gly
 1               5                  10                  15      
Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu
            20                  25                  30          
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
        35                  40                  45              
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
    50                  55                  60                  
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
65                  70                  75                  80  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
                85                  90                  95      
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
            100                 105                 110         
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
        115                 120                 125             
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
    130                 135                 140                 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
145                 150                 155                 160 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
                165                 170                 175     
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
            180                 185                 190         
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
        195                 200                 205             
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
    210                 215                 220                 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
225                 230                 235                 240 
Leu Ser Leu Gly Lys
                245 


<210> 208
<211> 792
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3251).

<400> 208
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactcctgcg agcacttccg ctggtgcaag ccggtgggag gcggaggaag cggcggaggc 120
ggatcctgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc 180
cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 240
gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 300
gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 360
agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc 420
tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 480
cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc 540
agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 600
aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 660
ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 720
tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 780
tctctgggta aa                                                     792

<210> 209
<211> 264
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3251).

<400> 209
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val
            20                  25                  30          
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala
        35                  40                  45              
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
    50                  55                  60                  
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
65                  70                  75                  80  
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
                85                  90                  95      
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
            100                 105                 110         
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
        115                 120                 125             
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
    130                 135                 140                 
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
145                 150                 155                 160 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
                165                 170                 175     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
            180                 185                 190         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
        195                 200                 205             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
    210                 215                 220                 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
225                 230                 235                 240 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                245                 250                 255     

Ser Leu Ser Leu Ser Leu Gly Lys
            260                 


<210> 210
<211> 11927
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3251).

<400> 210
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactcctgcg agcacttccg 1680
ctggtgcaag ccggtgggag gcggaggaag cggcggaggc ggatcctgcc caccgtgccc 1740
agcacctgaa ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac 1800
cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga 1860
ccctgaggtc aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa 1920
gccgcgggag gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca 1980
ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc 2040
ccccatcgag aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac 2100
cctgccccca tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa 2160
aggcttctat cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa 2220
ctacaagacc acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct 2280
caccgtggac aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga 2340
ggctctgcac aaccactaca cgcagaagag cctctccctg tctctgggta aatgagggcc 2400
cgtttaaaca gatccagaca tgataagata cattgatgag tttggacaaa ccacaactag 2460
aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac 2520
cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt 2580
tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtatggc 2640
tgattatgat ccggctgcct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg 2700
cagctcccgg agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt 2760
caggcgtcag cgggtgttgg cgggtgtcgg ggcgcagcca tgaggtcgac tctagaggat 2820
cgatgccccg ccccggacga actaaacctg actacgacat ctctgcccct tcttcgcggg 2880
gcagtgcatg taatcccttc agttggttgg tacaacttgc caactgggcc ctgttccaca 2940
tgtgacacgg ggggggacca aacacaaagg ggttctctga ctgtagttga catccttata 3000
aatggatgtg cacatttgcc aacactgagt ggctttcatc ctggagcaga ctttgcagtc 3060
tgtggactgc aacacaacat tgcctttatg tgtaactctt ggctgaagct cttacaccaa 3120
tgctggggga catgtacctc ccaggggccc aggaagacta cgggaggcta caccaacgtc 3180
aatcagaggg gcctgtgtag ctaccgataa gcggaccctc aagagggcat tagcaatagt 3240
gtttataagg cccccttgtt aaccctaaac gggtagcata tgcttcccgg gtagtagtat 3300
atactatcca gactaaccct aattcaatag catatgttac ccaacgggaa gcatatgcta 3360
tcgaattagg gttagtaaaa gggtcctaag gaacagcgat atctcccacc ccatgagctg 3420
tcacggtttt atttacatgg ggtcaggatt ccacgagggt agtgaaccat tttagtcaca 3480
agggcagtgg ctgaagatca aggagcgggc agtgaactct cctgaatctt cgcctgcttc 3540
ttcattctcc ttcgtttagc taatagaata actgctgagt tgtgaacagt aaggtgtatg 3600
tgaggtgctc gaaaacaagg tttcaggtga cgcccccaga ataaaatttg gacggggggt 3660
tcagtggtgg cattgtgcta tgacaccaat ataaccctca caaacccctt gggcaataaa 3720
tactagtgta ggaatgaaac attctgaata tctttaacaa tagaaatcca tggggtgggg 3780
acaagccgta aagactggat gtccatctca cacgaattta tggctatggg caacacataa 3840
tcctagtgca atatgatact ggggttatta agatgtgtcc caggcaggga ccaagacagg 3900
tgaaccatgt tgttacactc tatttgtaac aaggggaaag agagtggacg ccgacagcag 3960
cggactccac tggttgtctc taacaccccc gaaaattaaa cggggctcca cgccaatggg 4020
gcccataaac aaagacaagt ggccactctt ttttttgaaa ttgtggagtg ggggcacgcg 4080
tcagccccca cacgccgccc tgcggttttg gactgtaaaa taagggtgta ataacttggc 4140
tgattgtaac cccgctaacc actgcggtca aaccacttgc ccacaaaacc actaatggca 4200
ccccggggaa tacctgcata agtaggtggg cgggccaaga taggggcgcg attgctgcga 4260
tctggaggac aaattacaca cacttgcgcc tgagcgccaa gcacagggtt gttggtcctc 4320
atattcacga ggtcgctgag agcacggtgg gctaatgttg ccatgggtag catatactac 4380
ccaaatatct ggatagcata tgctatccta atctatatct gggtagcata ggctatccta 4440
atctatatct gggtagcata tgctatccta atctatatct gggtagtata tgctatccta 4500
atttatatct gggtagcata ggctatccta atctatatct gggtagcata tgctatccta 4560
atctatatct gggtagtata tgctatccta atctgtatcc gggtagcata tgctatccta 4620
atagagatta gggtagtata tgctatccta atttatatct gggtagcata tactacccaa 4680
atatctggat agcatatgct atcctaatct atatctgggt agcatatgct atcctaatct 4740
atatctgggt agcataggct atcctaatct atatctgggt agcatatgct atcctaatct 4800
atatctgggt agtatatgct atcctaattt atatctgggt agcataggct atcctaatct 4860
atatctgggt agcatatgct atcctaatct atatctgggt agtatatgct atcctaatct 4920
gtatccgggt agcatatgct atcctcatgc atatacagtc agcatatgat acccagtagt 4980
agagtgggag tgctatcctt tgcatatgcc gccacctccc aagggggcgt gaattttcgc 5040
tgcttgtcct tttcctgctg gttgctccca ttcttaggtg aatttaagga ggccaggcta 5100
aagccgtcgc atgtctgatt gctcaccagg taaatgtcgc taatgttttc caacgcgaga 5160
aggtgttgag cgcggagctg agtgacgtga caacatgggt atgcccaatt gccccatgtt 5220
gggaggacga aaatggtgac aagacagatg gccagaaata caccaacagc acgcatgatg 5280
tctactgggg atttattctt tagtgcgggg gaatacacgg cttttaatac gattgagggc 5340
gtctcctaac aagttacatc actcctgccc ttcctcaccc tcatctccat cacctccttc 5400
atctccgtca tctccgtcat caccctccgc ggcagcccct tccaccatag gtggaaacca 5460
gggaggcaaa tctactccat cgtcaaagct gcacacagtc accctgatat tgcaggtagg 5520
agcgggcttt gtcataacaa ggtccttaat cgcatccttc aaaacctcag caaatatatg 5580
agtttgtaaa aagaccatga aataacagac aatggactcc cttagcgggc caggttgtgg 5640
gccgggtcca ggggccattc caaaggggag acgactcaat ggtgtaagac gacattgtgg 5700
aatagcaagg gcagttcctc gccttaggtt gtaaagggag gtcttactac ctccatatac 5760
gaacacaccg gcgacccaag ttccttcgtc ggtagtcctt tctacgtgac tcctagccag 5820
gagagctctt aaaccttctg caatgttctc aaatttcggg ttggaacctc cttgaccacg 5880
atgcttttcc aaaccaccct ccttttttgc gccctgcctc catcaccctg accccggggt 5940
ccagtgcttg ggccttctcc tgggtcatct gcggggccct gctctatcgc tcccgggggc 6000
acgtcaggct caccatctgg gccaccttct tggtggtatt caaaataatc ggcttcccct 6060
acagggtgga aaaatggcct tctacctgga gggggcctgc gcggtggaga cccggatgat 6120
gatgactgac tactgggact cctgggcctc ttttctccac gtccacgacc tctccccctg 6180
gctctttcac gacttccccc cctggctctt tcacgtcctc taccccggcg gcctccacta 6240
cctcctcgac cccggcctcc actacctcct cgaccccggc ctccactgcc tcctcgaccc 6300
cggcctccac ctcctgctcc tgcccctcct gctcctgccc ctcctcctgc tcctgcccct 6360
cctgcccctc ctgctcctgc ccctcctgcc cctcctgctc ctgcccctcc tgcccctcct 6420
gctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctgcccctcc tcctgctcct 6480
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6540
cctcctgctc ctgcccctcc tgctcctgcc cctcctgctc ctgcccctcc tgctcctgcc 6600
cctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctgctcctgc ccctcctgcc 6660
cctcctgccc ctcctgctcc tgcccctcct cctgctcctg cccctcctgc ccctcctgcc 6720
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 6780
gcccctcctg cccctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctcctgct 6840
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6900
cctcctcctg ctcctgcccc tcctgcccct cctgcccctc ctgcccctcc tcctgctcct 6960
gcccctcctc ctgctcctgc ccctcctgct cctgcccctc ccgctcctgc tcctgctcct 7020
gttccaccgt gggtcccttt gcagccaatg caacttggac gtttttgggg tctccggaca 7080
ccatctctat gtcttggccc tgatcctgag ccgcccgggg ctcctggtct tccgcctcct 7140
cgtcctcgtc ctcttccccg tcctcgtcca tggttatcac cccctcttct ttgaggtcca 7200
ctgccgccgg agccttctgg tccagatgtg tctcccttct ctcctaggcc atttccaggt 7260
cctgtacctg gcccctcgtc agacatgatt cacactaaaa gagatcaata gacatcttta 7320
ttagacgacg ctcagtgaat acagggagtg cagactcctg ccccctccaa cagccccccc 7380
accctcatcc ccttcatggt cgctgtcaga cagatccagg tctgaaaatt ccccatcctc 7440
cgaaccatcc tcgtcctcat caccaattac tcgcagcccg gaaaactccc gctgaacatc 7500
ctcaagattt gcgtcctgag cctcaagcca ggcctcaaat tcctcgtccc cctttttgct 7560
ggacggtagg gatggggatt ctcgggaccc ctcctcttcc tcttcaaggt caccagacag 7620
agatgctact ggggcaacgg aagaaaagct gggtgcggcc tgtgaggatc agcttatcga 7680
tgataagctg tcaaacatga gaattcttga agacgaaagg gcctcgtgat acgcctattt 7740
ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga 7800
aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc 7860
atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt 7920
caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct 7980
cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt 8040
tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt 8100
tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtgttgac 8160
gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac 8220
tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct 8280
gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg 8340
aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg 8400
gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgcagca 8460
atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa 8520
caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt 8580
ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc 8640
attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg 8700
agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt 8760
aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt 8820
catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc 8880
ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct 8940
tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta 9000
ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc 9060
ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac 9120
ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct 9180
gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat 9240
aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg 9300
acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa 9360
gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg 9420
gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga 9480
cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc 9540
aacgcggcct ttttacggtt cctggccttt tgctggcctt gaagctgtcc ctgatggtcg 9600
tcatctacct gcctggacag catggcctgc aacgcgggca tcccgatgcc gccggaagcg 9660
agaagaatca taatggggaa ggccatccag cctcgcgtcg cgaacgccag caagacgtag 9720
cccagcgcgt cggccccgag atgcgccgcg tgcggctgct ggagatggcg gacgcgatgg 9780
atatgttctg ccaagggttg gtttgcgcat tcacagttct ccgcaagaat tgattggctc 9840
caattcttgg agtggtgaat ccgttagcga ggtgccgccc tgcttcatcc ccgtggcccg 9900
ttgctcgcgt ttgctggcgg tgtccccgga agaaatatat ttgcatgtct ttagttctat 9960
gatgacacaa accccgccca gcgtcttgtc attggcgaat tcgaacacgc agatgcagtc 10020
ggggcggcgc ggtccgaggt ccacttcgca tattaaggtg acgcgtgtgg cctcgaacac 10080
cgagcgaccc tgcagcgacc cgcttaacag cgtcaacagc gtgccgcaga tcccgggggg 10140
caatgagata tgaaaaagcc tgaactcacc gcgacgtctg tcgagaagtt tctgatcgaa 10200
aagttcgaca gcgtctccga cctgatgcag ctctcggagg gcgaagaatc tcgtgctttc 10260
agcttcgatg taggagggcg tggatatgtc ctgcgggtaa atagctgcgc cgatggtttc 10320
tacaaagatc gttatgttta tcggcacttt gcatcggccg cgctcccgat tccggaagtg 10380
cttgacattg gggaattcag cgagagcctg acctattgca tctcccgccg tgcacagggt 10440
gtcacgttgc aagacctgcc tgaaaccgaa ctgcccgctg ttctgcagcc ggtcgcggag 10500
gccatggatg cgatcgctgc ggccgatctt agccagacga gcgggttcgg cccattcgga 10560
ccgcaaggaa tcggtcaata cactacatgg cgtgatttca tatgcgcgat tgctgatccc 10620
catgtgtatc actggcaaac tgtgatggac gacaccgtca gtgcgtccgt cgcgcaggct 10680
ctcgatgagc tgatgctttg ggccgaggac tgccccgaag tccggcacct cgtgcacgcg 10740
gatttcggct ccaacaatgt cctgacggac aatggccgca taacagcggt cattgactgg 10800
agcgaggcga tgttcgggga ttcccaatac gaggtcgcca acatcttctt ctggaggccg 10860
tggttggctt gtatggagca gcagacgcgc tacttcgagc ggaggcatcc ggagcttgca 10920
ggatcgccgc ggctccgggc gtatatgctc cgcattggtc ttgaccaact ctatcagagc 10980
ttggttgacg gcaatttcga tgatgcagct tgggcgcagg gtcgatgcga cgcaatcgtc 11040
cgatccggag ccgggactgt cgggcgtaca caaatcgccc gcagaagcgc ggccgtctgg 11100
accgatggct gtgtagaagt actcgccgat agtggaaacc gacgccccag cactcgtccg 11160
gatcgggaga tgggggaggc taactgaaac acggaaggag acaataccgg aaggaacccg 11220
cgctatgacg gcaataaaaa gacagaataa aacgcacggg tgttgggtcg tttgttcata 11280
aacgcggggt tcggtcccag ggctggcact ctgtcgatac cccaccgaga ccccattggg 11340
gccaatacgc ccgcgtttct tccttttccc caccccaccc cccaagttcg ggtgaaggcc 11400
cagggctcgc agccaacgtc ggggcggcag gccctgccat agccactggc cccgtgggtt 11460
agggacgggg tcccccatgg ggaatggttt atggttcgtg ggggttatta ttttgggcgt 11520
tgcgtggggt caggtccacg actggactga gcagacagac ccatggtttt tggatggcct 11580
gggcatggac cgcatgtact ggcgcgacac gaacaccggg cgtctgtggc tgccaaacac 11640
ccccgacccc caaaaaccac cgcgcggatt tctggcgtgc caagctagtc gaccaattct 11700
catgtttgac agcttatcat cgcagatccg ggcaacgttg ttgccattgc tgcaggcgca 11760
gaactggtag gtatggaaga tctatacatt gaatcaatat tggcaattag ccatattagt 11820
cattggttat atagcataaa tcaatattgg ctattggcca ttgcatacgt tgtatctata 11880
tcataatatg tacatttata ttggctcatg tccaatatga ccgccat               11927



<210> 211
<211> 735
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3650).

<400> 211
tcctactcct gcgagcactt ccgctggtgc aagccggtgg gaggcggagg aagcggcgga 60
ggcggatcct gcccaccatg cccggcgcct gaggccgccg ggggaccatc agtcttcctg 120
ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg 180
gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg 240
gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg 300
gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag 360
gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag 420
cctcgagagc cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag 480
gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag 540
agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc 600
tccttcttcc tctacagcag gctaaccgtg gacaagagca ggtggcagga ggggaatgtc 660
ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa aagcttgtcc 720
ctgtctctgg gtaaa                                                  735

<210> 212
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3650).

<400> 212
Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly Gly Gly
 1               5                  10                  15      
Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala
            20                  25                  30          
Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
        35                  40                  45              
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
    50                  55                  60                  
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
65                  70                  75                  80  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
                85                  90                  95      
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
            100                 105                 110         
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
        115                 120                 125             
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
    130                 135                 140                 
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
145                 150                 155                 160 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
                165                 170                 175     
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
            180                 185                 190         
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
        195                 200                 205             
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
    210                 215                 220                 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
225                 230                 235                 240 
Leu Ser Leu Gly Lys
                245 


<210> 213
<211> 792
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3650).

<400> 213
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactcctgcg agcacttccg ctggtgcaag ccggtgggag gcggaggaag cggcggaggc 120
ggatcctgcc caccatgccc ggcgcctgag gccgccgggg gaccatcagt cttcctgttc 180
cccccaaaac ccaaggacac tctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg 240
gtggacgtga gccaggaaga ccccgaggtc cagttcaact ggtacgtgga tggcgtggag 300
gtgcataatg ccaagacaaa gccgcgggag gagcagttca acagcacgta ccgtgtggtc 360
agcgtcctca ccgtcctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc 420
tccaacaaag gcctcccgtc ctccatcgag aaaaccatct ccaaagccaa agggcagcct 480
cgagagccac aggtgtacac cctgccccca tcccaggagg agatgaccaa gaaccaggtc 540
agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc 600
aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 660
ttcttcctct acagcaggct aaccgtggac aagagcaggt ggcaggaggg gaatgtcttc 720
tcatgctccg tgatgcatga ggctctgcac aaccactaca cacagaaaag cttgtccctg 780
tctctgggta aa                                                     792

<210> 214
<211> 264
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3650).

<400> 214
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val
            20                  25                  30          
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala
        35                  40                  45              
Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
    50                  55                  60                  
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
65                  70                  75                  80  
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
                85                  90                  95      
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
            100                 105                 110         
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
        115                 120                 125             
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
    130                 135                 140                 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
145                 150                 155                 160 

Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
                165                 170                 175     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
            180                 185                 190         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
        195                 200                 205             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
    210                 215                 220                 
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe
225                 230                 235                 240 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                245                 250                 255     
Ser Leu Ser Leu Ser Leu Gly Lys
            260                 


<210> 215
<211> 11927
<212> DNA
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3650).

<400> 215
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactcctgcg agcacttccg 1680
ctggtgcaag ccggtgggag gcggaggaag cggcggaggc ggatcctgcc caccatgccc 1740
ggcgcctgag gccgccgggg gaccatcagt cttcctgttc cccccaaaac ccaaggacac 1800
tctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg gtggacgtga gccaggaaga 1860
ccccgaggtc cagttcaact ggtacgtgga tggcgtggag gtgcataatg ccaagacaaa 1920
gccgcgggag gagcagttca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca 1980
ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc tccaacaaag gcctcccgtc 2040
ctccatcgag aaaaccatct ccaaagccaa agggcagcct cgagagccac aggtgtacac 2100
cctgccccca tcccaggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa 2160
aggcttctac cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa 2220
ctacaagacc acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaggct 2280
aaccgtggac aagagcaggt ggcaggaggg gaatgtcttc tcatgctccg tgatgcatga 2340
ggctctgcac aaccactaca cacagaaaag cttgtccctg tctctgggta aatgagggcc 2400
cgtttaaaca gatccagaca tgataagata cattgatgag tttggacaaa ccacaactag 2460
aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac 2520
cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt 2580
tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtatggc 2640
tgattatgat ccggctgcct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg 2700
cagctcccgg agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt 2760
caggcgtcag cgggtgttgg cgggtgtcgg ggcgcagcca tgaggtcgac tctagaggat 2820
cgatgccccg ccccggacga actaaacctg actacgacat ctctgcccct tcttcgcggg 2880
gcagtgcatg taatcccttc agttggttgg tacaacttgc caactgggcc ctgttccaca 2940
tgtgacacgg ggggggacca aacacaaagg ggttctctga ctgtagttga catccttata 3000
aatggatgtg cacatttgcc aacactgagt ggctttcatc ctggagcaga ctttgcagtc 3060
tgtggactgc aacacaacat tgcctttatg tgtaactctt ggctgaagct cttacaccaa 3120
tgctggggga catgtacctc ccaggggccc aggaagacta cgggaggcta caccaacgtc 3180
aatcagaggg gcctgtgtag ctaccgataa gcggaccctc aagagggcat tagcaatagt 3240
gtttataagg cccccttgtt aaccctaaac gggtagcata tgcttcccgg gtagtagtat 3300
atactatcca gactaaccct aattcaatag catatgttac ccaacgggaa gcatatgcta 3360
tcgaattagg gttagtaaaa gggtcctaag gaacagcgat atctcccacc ccatgagctg 3420
tcacggtttt atttacatgg ggtcaggatt ccacgagggt agtgaaccat tttagtcaca 3480
agggcagtgg ctgaagatca aggagcgggc agtgaactct cctgaatctt cgcctgcttc 3540
ttcattctcc ttcgtttagc taatagaata actgctgagt tgtgaacagt aaggtgtatg 3600
tgaggtgctc gaaaacaagg tttcaggtga cgcccccaga ataaaatttg gacggggggt 3660
tcagtggtgg cattgtgcta tgacaccaat ataaccctca caaacccctt gggcaataaa 3720
tactagtgta ggaatgaaac attctgaata tctttaacaa tagaaatcca tggggtgggg 3780
acaagccgta aagactggat gtccatctca cacgaattta tggctatggg caacacataa 3840
tcctagtgca atatgatact ggggttatta agatgtgtcc caggcaggga ccaagacagg 3900
tgaaccatgt tgttacactc tatttgtaac aaggggaaag agagtggacg ccgacagcag 3960
cggactccac tggttgtctc taacaccccc gaaaattaaa cggggctcca cgccaatggg 4020
gcccataaac aaagacaagt ggccactctt ttttttgaaa ttgtggagtg ggggcacgcg 4080
tcagccccca cacgccgccc tgcggttttg gactgtaaaa taagggtgta ataacttggc 4140
tgattgtaac cccgctaacc actgcggtca aaccacttgc ccacaaaacc actaatggca 4200
ccccggggaa tacctgcata agtaggtggg cgggccaaga taggggcgcg attgctgcga 4260
tctggaggac aaattacaca cacttgcgcc tgagcgccaa gcacagggtt gttggtcctc 4320
atattcacga ggtcgctgag agcacggtgg gctaatgttg ccatgggtag catatactac 4380
ccaaatatct ggatagcata tgctatccta atctatatct gggtagcata ggctatccta 4440
atctatatct gggtagcata tgctatccta atctatatct gggtagtata tgctatccta 4500
atttatatct gggtagcata ggctatccta atctatatct gggtagcata tgctatccta 4560
atctatatct gggtagtata tgctatccta atctgtatcc gggtagcata tgctatccta 4620
atagagatta gggtagtata tgctatccta atttatatct gggtagcata tactacccaa 4680
atatctggat agcatatgct atcctaatct atatctgggt agcatatgct atcctaatct 4740
atatctgggt agcataggct atcctaatct atatctgggt agcatatgct atcctaatct 4800
atatctgggt agtatatgct atcctaattt atatctgggt agcataggct atcctaatct 4860
atatctgggt agcatatgct atcctaatct atatctgggt agtatatgct atcctaatct 4920
gtatccgggt agcatatgct atcctcatgc atatacagtc agcatatgat acccagtagt 4980
agagtgggag tgctatcctt tgcatatgcc gccacctccc aagggggcgt gaattttcgc 5040
tgcttgtcct tttcctgctg gttgctccca ttcttaggtg aatttaagga ggccaggcta 5100
aagccgtcgc atgtctgatt gctcaccagg taaatgtcgc taatgttttc caacgcgaga 5160
aggtgttgag cgcggagctg agtgacgtga caacatgggt atgcccaatt gccccatgtt 5220
gggaggacga aaatggtgac aagacagatg gccagaaata caccaacagc acgcatgatg 5280
tctactgggg atttattctt tagtgcgggg gaatacacgg cttttaatac gattgagggc 5340
gtctcctaac aagttacatc actcctgccc ttcctcaccc tcatctccat cacctccttc 5400
atctccgtca tctccgtcat caccctccgc ggcagcccct tccaccatag gtggaaacca 5460
gggaggcaaa tctactccat cgtcaaagct gcacacagtc accctgatat tgcaggtagg 5520
agcgggcttt gtcataacaa ggtccttaat cgcatccttc aaaacctcag caaatatatg 5580
agtttgtaaa aagaccatga aataacagac aatggactcc cttagcgggc caggttgtgg 5640
gccgggtcca ggggccattc caaaggggag acgactcaat ggtgtaagac gacattgtgg 5700
aatagcaagg gcagttcctc gccttaggtt gtaaagggag gtcttactac ctccatatac 5760
gaacacaccg gcgacccaag ttccttcgtc ggtagtcctt tctacgtgac tcctagccag 5820
gagagctctt aaaccttctg caatgttctc aaatttcggg ttggaacctc cttgaccacg 5880
atgcttttcc aaaccaccct ccttttttgc gccctgcctc catcaccctg accccggggt 5940
ccagtgcttg ggccttctcc tgggtcatct gcggggccct gctctatcgc tcccgggggc 6000
acgtcaggct caccatctgg gccaccttct tggtggtatt caaaataatc ggcttcccct 6060
acagggtgga aaaatggcct tctacctgga gggggcctgc gcggtggaga cccggatgat 6120
gatgactgac tactgggact cctgggcctc ttttctccac gtccacgacc tctccccctg 6180
gctctttcac gacttccccc cctggctctt tcacgtcctc taccccggcg gcctccacta 6240
cctcctcgac cccggcctcc actacctcct cgaccccggc ctccactgcc tcctcgaccc 6300
cggcctccac ctcctgctcc tgcccctcct gctcctgccc ctcctcctgc tcctgcccct 6360
cctgcccctc ctgctcctgc ccctcctgcc cctcctgctc ctgcccctcc tgcccctcct 6420
gctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctgcccctcc tcctgctcct 6480
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6540
cctcctgctc ctgcccctcc tgctcctgcc cctcctgctc ctgcccctcc tgctcctgcc 6600
cctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctgctcctgc ccctcctgcc 6660
cctcctgccc ctcctgctcc tgcccctcct cctgctcctg cccctcctgc ccctcctgcc 6720
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 6780
gcccctcctg cccctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctcctgct 6840
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6900
cctcctcctg ctcctgcccc tcctgcccct cctgcccctc ctgcccctcc tcctgctcct 6960
gcccctcctc ctgctcctgc ccctcctgct cctgcccctc ccgctcctgc tcctgctcct 7020
gttccaccgt gggtcccttt gcagccaatg caacttggac gtttttgggg tctccggaca 7080
ccatctctat gtcttggccc tgatcctgag ccgcccgggg ctcctggtct tccgcctcct 7140
cgtcctcgtc ctcttccccg tcctcgtcca tggttatcac cccctcttct ttgaggtcca 7200
ctgccgccgg agccttctgg tccagatgtg tctcccttct ctcctaggcc atttccaggt 7260
cctgtacctg gcccctcgtc agacatgatt cacactaaaa gagatcaata gacatcttta 7320
ttagacgacg ctcagtgaat acagggagtg cagactcctg ccccctccaa cagccccccc 7380
accctcatcc ccttcatggt cgctgtcaga cagatccagg tctgaaaatt ccccatcctc 7440
cgaaccatcc tcgtcctcat caccaattac tcgcagcccg gaaaactccc gctgaacatc 7500
ctcaagattt gcgtcctgag cctcaagcca ggcctcaaat tcctcgtccc cctttttgct 7560
ggacggtagg gatggggatt ctcgggaccc ctcctcttcc tcttcaaggt caccagacag 7620
agatgctact ggggcaacgg aagaaaagct gggtgcggcc tgtgaggatc agcttatcga 7680
tgataagctg tcaaacatga gaattcttga agacgaaagg gcctcgtgat acgcctattt 7740
ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga 7800
aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc 7860
atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt 7920
caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct 7980
cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt 8040
tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt 8100
tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtgttgac 8160
gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac 8220
tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct 8280
gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg 8340
aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg 8400
gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgcagca 8460
atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa 8520
caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt 8580
ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc 8640
attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg 8700
agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt 8760
aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt 8820
catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc 8880
ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct 8940
tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta 9000
ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc 9060
ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac 9120
ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct 9180
gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat 9240
aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg 9300
acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa 9360
gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg 9420
gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga 9480
cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc 9540
aacgcggcct ttttacggtt cctggccttt tgctggcctt gaagctgtcc ctgatggtcg 9600
tcatctacct gcctggacag catggcctgc aacgcgggca tcccgatgcc gccggaagcg 9660
agaagaatca taatggggaa ggccatccag cctcgcgtcg cgaacgccag caagacgtag 9720
cccagcgcgt cggccccgag atgcgccgcg tgcggctgct ggagatggcg gacgcgatgg 9780
atatgttctg ccaagggttg gtttgcgcat tcacagttct ccgcaagaat tgattggctc 9840
caattcttgg agtggtgaat ccgttagcga ggtgccgccc tgcttcatcc ccgtggcccg 9900
ttgctcgcgt ttgctggcgg tgtccccgga agaaatatat ttgcatgtct ttagttctat 9960
gatgacacaa accccgccca gcgtcttgtc attggcgaat tcgaacacgc agatgcagtc 10020
ggggcggcgc ggtccgaggt ccacttcgca tattaaggtg acgcgtgtgg cctcgaacac 10080
cgagcgaccc tgcagcgacc cgcttaacag cgtcaacagc gtgccgcaga tcccgggggg 10140
caatgagata tgaaaaagcc tgaactcacc gcgacgtctg tcgagaagtt tctgatcgaa 10200
aagttcgaca gcgtctccga cctgatgcag ctctcggagg gcgaagaatc tcgtgctttc 10260
agcttcgatg taggagggcg tggatatgtc ctgcgggtaa atagctgcgc cgatggtttc 10320
tacaaagatc gttatgttta tcggcacttt gcatcggccg cgctcccgat tccggaagtg 10380
cttgacattg gggaattcag cgagagcctg acctattgca tctcccgccg tgcacagggt 10440
gtcacgttgc aagacctgcc tgaaaccgaa ctgcccgctg ttctgcagcc ggtcgcggag 10500
gccatggatg cgatcgctgc ggccgatctt agccagacga gcgggttcgg cccattcgga 10560
ccgcaaggaa tcggtcaata cactacatgg cgtgatttca tatgcgcgat tgctgatccc 10620
catgtgtatc actggcaaac tgtgatggac gacaccgtca gtgcgtccgt cgcgcaggct 10680
ctcgatgagc tgatgctttg ggccgaggac tgccccgaag tccggcacct cgtgcacgcg 10740
gatttcggct ccaacaatgt cctgacggac aatggccgca taacagcggt cattgactgg 10800
agcgaggcga tgttcgggga ttcccaatac gaggtcgcca acatcttctt ctggaggccg 10860
tggttggctt gtatggagca gcagacgcgc tacttcgagc ggaggcatcc ggagcttgca 10920
ggatcgccgc ggctccgggc gtatatgctc cgcattggtc ttgaccaact ctatcagagc 10980
ttggttgacg gcaatttcga tgatgcagct tgggcgcagg gtcgatgcga cgcaatcgtc 11040
cgatccggag ccgggactgt cgggcgtaca caaatcgccc gcagaagcgc ggccgtctgg 11100
accgatggct gtgtagaagt actcgccgat agtggaaacc gacgccccag cactcgtccg 11160
gatcgggaga tgggggaggc taactgaaac acggaaggag acaataccgg aaggaacccg 11220
cgctatgacg gcaataaaaa gacagaataa aacgcacggg tgttgggtcg tttgttcata 11280
aacgcggggt tcggtcccag ggctggcact ctgtcgatac cccaccgaga ccccattggg 11340
gccaatacgc ccgcgtttct tccttttccc caccccaccc cccaagttcg ggtgaaggcc 11400
cagggctcgc agccaacgtc ggggcggcag gccctgccat agccactggc cccgtgggtt 11460
agggacgggg tcccccatgg ggaatggttt atggttcgtg ggggttatta ttttgggcgt 11520
tgcgtggggt caggtccacg actggactga gcagacagac ccatggtttt tggatggcct 11580
gggcatggac cgcatgtact ggcgcgacac gaacaccggg cgtctgtggc tgccaaacac 11640
ccccgacccc caaaaaccac cgcgcggatt tctggcgtgc caagctagtc gaccaattct 11700
catgtttgac agcttatcat cgcagatccg ggcaacgttg ttgccattgc tgcaggcgca 11760
gaactggtag gtatggaaga tctatacatt gaatcaatat tggcaattag ccatattagt 11820
cattggttat atagcataaa tcaatattgg ctattggcca ttgcatacgt tgtatctata 11880
tcataatatg tacatttata ttggctcatg tccaatatga ccgccat               11927



<210> 216
<211> 735
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3651).

<400> 216
tcctactcct gcgagcactt ccgctggtgc aagccggtgg gaggcggagg aagcggcgga 60
ggcggatcct gcccaccgtg cccagcacct gaagccgctg ggggaccgtc agtcttcctc 120
ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg 180
gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg 240
gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgggtg 300
gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag 360
gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag 420
ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag 480
gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag 540
agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc 600
tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc 660
ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc 720
ctgtctccgg gtaaa                                                  735

<210> 217
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3651).

<400> 217
Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly Gly Gly
 1               5                  10                  15      
Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala
            20                  25                  30          
Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
        35                  40                  45              
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
    50                  55                  60                  
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
65                  70                  75                  80  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
                85                  90                  95      
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
            100                 105                 110         
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
        115                 120                 125             
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
    130                 135                 140                 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
145                 150                 155                 160 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
                165                 170                 175     
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
            180                 185                 190         
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
        195                 200                 205             
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
    210                 215                 220                 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
225                 230                 235                 240 
Leu Ser Pro Gly Lys
                245 


<210> 218
<211> 792
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3651).

<400> 218
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactcctgcg agcacttccg ctggtgcaag ccggtgggag gcggaggaag cggcggaggc 120
ggatcctgcc caccgtgccc agcacctgaa gccgctgggg gaccgtcagt cttcctcttc 180
cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 240
gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 300
gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgggtggtc 360
agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc 420
tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 480
cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc 540
agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 600
aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 660
ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 720
tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 780
tctccgggta aa                                                     792

<210> 219
<211> 264
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3651).

<400> 219
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val
            20                  25                  30          
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala
        35                  40                  45              
Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
    50                  55                  60                  
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
65                  70                  75                  80  
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
                85                  90                  95      
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
            100                 105                 110         
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
        115                 120                 125             
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
    130                 135                 140                 
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
145                 150                 155                 160 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
                165                 170                 175     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
            180                 185                 190         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
        195                 200                 205             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
    210                 215                 220                 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
225                 230                 235                 240 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                245                 250                 255     
Ser Leu Ser Leu Ser Pro Gly Lys
            260                 


<210> 220
<211> 11927
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3651).

<400> 220
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactcctgcg agcacttccg 1680
ctggtgcaag ccggtgggag gcggaggaag cggcggaggc ggatcctgcc caccgtgccc 1740
agcacctgaa gccgctgggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac 1800
cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga 1860
ccctgaggtc aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa 1920
gccgcgggag gagcagtaca acagcacgta ccgggtggtc agcgtcctca ccgtcctgca 1980
ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc 2040
ccccatcgag aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac 2100
cctgccccca tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa 2160
aggcttctat cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa 2220
ctacaagacc acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct 2280
caccgtggac aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga 2340
ggctctgcac aaccactaca cgcagaagag cctctccctg tctccgggta aatgagggcc 2400
cgtttaaaca gatccagaca tgataagata cattgatgag tttggacaaa ccacaactag 2460
aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac 2520
cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt 2580
tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtatggc 2640
tgattatgat ccggctgcct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg 2700
cagctcccgg agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt 2760
caggcgtcag cgggtgttgg cgggtgtcgg ggcgcagcca tgaggtcgac tctagaggat 2820
cgatgccccg ccccggacga actaaacctg actacgacat ctctgcccct tcttcgcggg 2880
gcagtgcatg taatcccttc agttggttgg tacaacttgc caactgggcc ctgttccaca 2940
tgtgacacgg ggggggacca aacacaaagg ggttctctga ctgtagttga catccttata 3000
aatggatgtg cacatttgcc aacactgagt ggctttcatc ctggagcaga ctttgcagtc 3060
tgtggactgc aacacaacat tgcctttatg tgtaactctt ggctgaagct cttacaccaa 3120
tgctggggga catgtacctc ccaggggccc aggaagacta cgggaggcta caccaacgtc 3180
aatcagaggg gcctgtgtag ctaccgataa gcggaccctc aagagggcat tagcaatagt 3240
gtttataagg cccccttgtt aaccctaaac gggtagcata tgcttcccgg gtagtagtat 3300
atactatcca gactaaccct aattcaatag catatgttac ccaacgggaa gcatatgcta 3360
tcgaattagg gttagtaaaa gggtcctaag gaacagcgat atctcccacc ccatgagctg 3420
tcacggtttt atttacatgg ggtcaggatt ccacgagggt agtgaaccat tttagtcaca 3480
agggcagtgg ctgaagatca aggagcgggc agtgaactct cctgaatctt cgcctgcttc 3540
ttcattctcc ttcgtttagc taatagaata actgctgagt tgtgaacagt aaggtgtatg 3600
tgaggtgctc gaaaacaagg tttcaggtga cgcccccaga ataaaatttg gacggggggt 3660
tcagtggtgg cattgtgcta tgacaccaat ataaccctca caaacccctt gggcaataaa 3720
tactagtgta ggaatgaaac attctgaata tctttaacaa tagaaatcca tggggtgggg 3780
acaagccgta aagactggat gtccatctca cacgaattta tggctatggg caacacataa 3840
tcctagtgca atatgatact ggggttatta agatgtgtcc caggcaggga ccaagacagg 3900
tgaaccatgt tgttacactc tatttgtaac aaggggaaag agagtggacg ccgacagcag 3960
cggactccac tggttgtctc taacaccccc gaaaattaaa cggggctcca cgccaatggg 4020
gcccataaac aaagacaagt ggccactctt ttttttgaaa ttgtggagtg ggggcacgcg 4080
tcagccccca cacgccgccc tgcggttttg gactgtaaaa taagggtgta ataacttggc 4140
tgattgtaac cccgctaacc actgcggtca aaccacttgc ccacaaaacc actaatggca 4200
ccccggggaa tacctgcata agtaggtggg cgggccaaga taggggcgcg attgctgcga 4260
tctggaggac aaattacaca cacttgcgcc tgagcgccaa gcacagggtt gttggtcctc 4320
atattcacga ggtcgctgag agcacggtgg gctaatgttg ccatgggtag catatactac 4380
ccaaatatct ggatagcata tgctatccta atctatatct gggtagcata ggctatccta 4440
atctatatct gggtagcata tgctatccta atctatatct gggtagtata tgctatccta 4500
atttatatct gggtagcata ggctatccta atctatatct gggtagcata tgctatccta 4560
atctatatct gggtagtata tgctatccta atctgtatcc gggtagcata tgctatccta 4620
atagagatta gggtagtata tgctatccta atttatatct gggtagcata tactacccaa 4680
atatctggat agcatatgct atcctaatct atatctgggt agcatatgct atcctaatct 4740
atatctgggt agcataggct atcctaatct atatctgggt agcatatgct atcctaatct 4800
atatctgggt agtatatgct atcctaattt atatctgggt agcataggct atcctaatct 4860
atatctgggt agcatatgct atcctaatct atatctgggt agtatatgct atcctaatct 4920
gtatccgggt agcatatgct atcctcatgc atatacagtc agcatatgat acccagtagt 4980
agagtgggag tgctatcctt tgcatatgcc gccacctccc aagggggcgt gaattttcgc 5040
tgcttgtcct tttcctgctg gttgctccca ttcttaggtg aatttaagga ggccaggcta 5100
aagccgtcgc atgtctgatt gctcaccagg taaatgtcgc taatgttttc caacgcgaga 5160
aggtgttgag cgcggagctg agtgacgtga caacatgggt atgcccaatt gccccatgtt 5220
gggaggacga aaatggtgac aagacagatg gccagaaata caccaacagc acgcatgatg 5280
tctactgggg atttattctt tagtgcgggg gaatacacgg cttttaatac gattgagggc 5340
gtctcctaac aagttacatc actcctgccc ttcctcaccc tcatctccat cacctccttc 5400
atctccgtca tctccgtcat caccctccgc ggcagcccct tccaccatag gtggaaacca 5460
gggaggcaaa tctactccat cgtcaaagct gcacacagtc accctgatat tgcaggtagg 5520
agcgggcttt gtcataacaa ggtccttaat cgcatccttc aaaacctcag caaatatatg 5580
agtttgtaaa aagaccatga aataacagac aatggactcc cttagcgggc caggttgtgg 5640
gccgggtcca ggggccattc caaaggggag acgactcaat ggtgtaagac gacattgtgg 5700
aatagcaagg gcagttcctc gccttaggtt gtaaagggag gtcttactac ctccatatac 5760
gaacacaccg gcgacccaag ttccttcgtc ggtagtcctt tctacgtgac tcctagccag 5820
gagagctctt aaaccttctg caatgttctc aaatttcggg ttggaacctc cttgaccacg 5880
atgcttttcc aaaccaccct ccttttttgc gccctgcctc catcaccctg accccggggt 5940
ccagtgcttg ggccttctcc tgggtcatct gcggggccct gctctatcgc tcccgggggc 6000
acgtcaggct caccatctgg gccaccttct tggtggtatt caaaataatc ggcttcccct 6060
acagggtgga aaaatggcct tctacctgga gggggcctgc gcggtggaga cccggatgat 6120
gatgactgac tactgggact cctgggcctc ttttctccac gtccacgacc tctccccctg 6180
gctctttcac gacttccccc cctggctctt tcacgtcctc taccccggcg gcctccacta 6240
cctcctcgac cccggcctcc actacctcct cgaccccggc ctccactgcc tcctcgaccc 6300
cggcctccac ctcctgctcc tgcccctcct gctcctgccc ctcctcctgc tcctgcccct 6360
cctgcccctc ctgctcctgc ccctcctgcc cctcctgctc ctgcccctcc tgcccctcct 6420
gctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctgcccctcc tcctgctcct 6480
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6540
cctcctgctc ctgcccctcc tgctcctgcc cctcctgctc ctgcccctcc tgctcctgcc 6600
cctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctgctcctgc ccctcctgcc 6660
cctcctgccc ctcctgctcc tgcccctcct cctgctcctg cccctcctgc ccctcctgcc 6720
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 6780
gcccctcctg cccctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctcctgct 6840
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6900
cctcctcctg ctcctgcccc tcctgcccct cctgcccctc ctgcccctcc tcctgctcct 6960
gcccctcctc ctgctcctgc ccctcctgct cctgcccctc ccgctcctgc tcctgctcct 7020
gttccaccgt gggtcccttt gcagccaatg caacttggac gtttttgggg tctccggaca 7080
ccatctctat gtcttggccc tgatcctgag ccgcccgggg ctcctggtct tccgcctcct 7140
cgtcctcgtc ctcttccccg tcctcgtcca tggttatcac cccctcttct ttgaggtcca 7200
ctgccgccgg agccttctgg tccagatgtg tctcccttct ctcctaggcc atttccaggt 7260
cctgtacctg gcccctcgtc agacatgatt cacactaaaa gagatcaata gacatcttta 7320
ttagacgacg ctcagtgaat acagggagtg cagactcctg ccccctccaa cagccccccc 7380
accctcatcc ccttcatggt cgctgtcaga cagatccagg tctgaaaatt ccccatcctc 7440
cgaaccatcc tcgtcctcat caccaattac tcgcagcccg gaaaactccc gctgaacatc 7500
ctcaagattt gcgtcctgag cctcaagcca ggcctcaaat tcctcgtccc cctttttgct 7560
ggacggtagg gatggggatt ctcgggaccc ctcctcttcc tcttcaaggt caccagacag 7620
agatgctact ggggcaacgg aagaaaagct gggtgcggcc tgtgaggatc agcttatcga 7680
tgataagctg tcaaacatga gaattcttga agacgaaagg gcctcgtgat acgcctattt 7740
ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga 7800
aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc 7860
atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt 7920
caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct 7980
cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt 8040
tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt 8100
tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtgttgac 8160
gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac 8220
tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct 8280
gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg 8340
aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg 8400
gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgcagca 8460
atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa 8520
caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt 8580
ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc 8640
attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg 8700
agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt 8760
aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt 8820
catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc 8880
ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct 8940
tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta 9000
ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc 9060
ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac 9120
ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct 9180
gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat 9240
aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg 9300
acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa 9360
gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg 9420
gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga 9480
cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc 9540
aacgcggcct ttttacggtt cctggccttt tgctggcctt gaagctgtcc ctgatggtcg 9600
tcatctacct gcctggacag catggcctgc aacgcgggca tcccgatgcc gccggaagcg 9660
agaagaatca taatggggaa ggccatccag cctcgcgtcg cgaacgccag caagacgtag 9720
cccagcgcgt cggccccgag atgcgccgcg tgcggctgct ggagatggcg gacgcgatgg 9780
atatgttctg ccaagggttg gtttgcgcat tcacagttct ccgcaagaat tgattggctc 9840
caattcttgg agtggtgaat ccgttagcga ggtgccgccc tgcttcatcc ccgtggcccg 9900
ttgctcgcgt ttgctggcgg tgtccccgga agaaatatat ttgcatgtct ttagttctat 9960
gatgacacaa accccgccca gcgtcttgtc attggcgaat tcgaacacgc agatgcagtc 10020
ggggcggcgc ggtccgaggt ccacttcgca tattaaggtg acgcgtgtgg cctcgaacac 10080
cgagcgaccc tgcagcgacc cgcttaacag cgtcaacagc gtgccgcaga tcccgggggg 10140
caatgagata tgaaaaagcc tgaactcacc gcgacgtctg tcgagaagtt tctgatcgaa 10200
aagttcgaca gcgtctccga cctgatgcag ctctcggagg gcgaagaatc tcgtgctttc 10260
agcttcgatg taggagggcg tggatatgtc ctgcgggtaa atagctgcgc cgatggtttc 10320
tacaaagatc gttatgttta tcggcacttt gcatcggccg cgctcccgat tccggaagtg 10380
cttgacattg gggaattcag cgagagcctg acctattgca tctcccgccg tgcacagggt 10440
gtcacgttgc aagacctgcc tgaaaccgaa ctgcccgctg ttctgcagcc ggtcgcggag 10500
gccatggatg cgatcgctgc ggccgatctt agccagacga gcgggttcgg cccattcgga 10560
ccgcaaggaa tcggtcaata cactacatgg cgtgatttca tatgcgcgat tgctgatccc 10620
catgtgtatc actggcaaac tgtgatggac gacaccgtca gtgcgtccgt cgcgcaggct 10680
ctcgatgagc tgatgctttg ggccgaggac tgccccgaag tccggcacct cgtgcacgcg 10740
gatttcggct ccaacaatgt cctgacggac aatggccgca taacagcggt cattgactgg 10800
agcgaggcga tgttcgggga ttcccaatac gaggtcgcca acatcttctt ctggaggccg 10860
tggttggctt gtatggagca gcagacgcgc tacttcgagc ggaggcatcc ggagcttgca 10920
ggatcgccgc ggctccgggc gtatatgctc cgcattggtc ttgaccaact ctatcagagc 10980
ttggttgacg gcaatttcga tgatgcagct tgggcgcagg gtcgatgcga cgcaatcgtc 11040
cgatccggag ccgggactgt cgggcgtaca caaatcgccc gcagaagcgc ggccgtctgg 11100
accgatggct gtgtagaagt actcgccgat agtggaaacc gacgccccag cactcgtccg 11160
gatcgggaga tgggggaggc taactgaaac acggaaggag acaataccgg aaggaacccg 11220
cgctatgacg gcaataaaaa gacagaataa aacgcacggg tgttgggtcg tttgttcata 11280
aacgcggggt tcggtcccag ggctggcact ctgtcgatac cccaccgaga ccccattggg 11340
gccaatacgc ccgcgtttct tccttttccc caccccaccc cccaagttcg ggtgaaggcc 11400
cagggctcgc agccaacgtc ggggcggcag gccctgccat agccactggc cccgtgggtt 11460
agggacgggg tcccccatgg ggaatggttt atggttcgtg ggggttatta ttttgggcgt 11520
tgcgtggggt caggtccacg actggactga gcagacagac ccatggtttt tggatggcct 11580
gggcatggac cgcatgtact ggcgcgacac gaacaccggg cgtctgtggc tgccaaacac 11640
ccccgacccc caaaaaccac cgcgcggatt tctggcgtgc caagctagtc gaccaattct 11700
catgtttgac agcttatcat cgcagatccg ggcaacgttg ttgccattgc tgcaggcgca 11760
gaactggtag gtatggaaga tctatacatt gaatcaatat tggcaattag ccatattagt 11820
cattggttat atagcataaa tcaatattgg ctattggcca ttgcatacgt tgtatctata 11880
tcataatatg tacatttata ttggctcatg tccaatatga ccgccat               11927



<210> 221
<211> 729
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3390).

<400> 221
cagatccagt cctactcctg cgagcacttc cgctggtgca agccggtggg aggaggcgga 60
tcctgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc 120
ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 180
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 240
cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 300
gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc 360
aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga 420
gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 480
ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 540
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc 600
ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca 660
tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 720
ctgggtaaa                                                         729

<210> 222
<211> 243
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3390).

<400> 222
Gln Ile Gln Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val
 1               5                  10                  15      
Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
            20                  25                  30          
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
        35                  40                  45              
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
    50                  55                  60                  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
65                  70                  75                  80  

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                85                  90                  95      
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
            100                 105                 110         
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
        115                 120                 125             
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
    130                 135                 140                 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
145                 150                 155                 160 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
                165                 170                 175     
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
            180                 185                 190         
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
        195                 200                 205             
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
    210                 215                 220                 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
225                 230                 235                 240 
Leu Gly Lys
            


<210> 223
<211> 786
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal and V1 (p3390).

<400> 223
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcccag 60
atccagtcct actcctgcga gcacttccgc tggtgcaagc cggtgggagg aggcggatcc 120
tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca 180
aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac 240
gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat 300
aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc 360
ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac 420
aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa 480
ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg 540
acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg 600
cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc 660
ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc 720
tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctctg 780
ggtaaa                                                            786

<210> 224
<211> 262
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal and V1 encoded by an in
      vitro synthesized DNA (p3390).

<400> 224
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Gln Ile Gln Ser Tyr Ser Cys Glu His Phe Arg Trp Cys
            20                  25                  30          
Lys Pro Val Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu
        35                  40                  45              
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
    50                  55                  60                  
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
65                  70                  75                  80  
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
                85                  90                  95      
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
            100                 105                 110         
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
        115                 120                 125             
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
    130                 135                 140                 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
145                 150                 155                 160 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
                165                 170                 175     
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
            180                 185                 190         
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
        195                 200                 205             
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
    210                 215                 220                 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
225                 230                 235                 240 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
                245                 250                 255     
Ser Leu Ser Leu Gly Lys
            260         


<210> 225
<211> 11921
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3390).

<400> 225
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcccag atccagtcct actcctgcga 1680
gcacttccgc tggtgcaagc cggtgggagg aggcggatcc tgcccaccgt gcccagcacc 1740
tgaactcctg gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat 1800
gatctcccgg acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga 1860
ggtcaagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg 1920
ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga 1980
ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat 2040
cgagaaaacc atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc 2100
cccatcccgg gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt 2160
ctatcccagc gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa 2220
gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt 2280
ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct 2340
gcacaaccac tacacgcaga agagcctctc cctgtctctg ggtaaatgag ggcccgttta 2400
aacagatcca gacatgataa gatacattga tgagtttgga caaaccacaa ctagaatgca 2460
gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat 2520
aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg 2580
ggaggtgtgg gaggtttttt aaagcaagta aaacctctac aaatgtggta tggctgatta 2640
tgatccggct gcctcgcgcg tttcggtgat gacggtgaaa acctctgaca catgcagctc 2700
ccggagacgg tcacagcttg tctgtaagcg gatgccggga gcagacaagc ccgtcaggcg 2760
tcagcgggtg ttggcgggtg tcggggcgca gccatgaggt cgactctaga ggatcgatgc 2820
cccgccccgg acgaactaaa cctgactacg acatctctgc cccttcttcg cggggcagtg 2880
catgtaatcc cttcagttgg ttggtacaac ttgccaactg ggccctgttc cacatgtgac 2940
acgggggggg accaaacaca aaggggttct ctgactgtag ttgacatcct tataaatgga 3000
tgtgcacatt tgccaacact gagtggcttt catcctggag cagactttgc agtctgtgga 3060
ctgcaacaca acattgcctt tatgtgtaac tcttggctga agctcttaca ccaatgctgg 3120
gggacatgta cctcccaggg gcccaggaag actacgggag gctacaccaa cgtcaatcag 3180
aggggcctgt gtagctaccg ataagcggac cctcaagagg gcattagcaa tagtgtttat 3240
aaggccccct tgttaaccct aaacgggtag catatgcttc ccgggtagta gtatatacta 3300
tccagactaa ccctaattca atagcatatg ttacccaacg ggaagcatat gctatcgaat 3360
tagggttagt aaaagggtcc taaggaacag cgatatctcc caccccatga gctgtcacgg 3420
ttttatttac atggggtcag gattccacga gggtagtgaa ccattttagt cacaagggca 3480
gtggctgaag atcaaggagc gggcagtgaa ctctcctgaa tcttcgcctg cttcttcatt 3540
ctccttcgtt tagctaatag aataactgct gagttgtgaa cagtaaggtg tatgtgaggt 3600
gctcgaaaac aaggtttcag gtgacgcccc cagaataaaa tttggacggg gggttcagtg 3660
gtggcattgt gctatgacac caatataacc ctcacaaacc ccttgggcaa taaatactag 3720
tgtaggaatg aaacattctg aatatcttta acaatagaaa tccatggggt ggggacaagc 3780
cgtaaagact ggatgtccat ctcacacgaa tttatggcta tgggcaacac ataatcctag 3840
tgcaatatga tactggggtt attaagatgt gtcccaggca gggaccaaga caggtgaacc 3900
atgttgttac actctatttg taacaagggg aaagagagtg gacgccgaca gcagcggact 3960
ccactggttg tctctaacac ccccgaaaat taaacggggc tccacgccaa tggggcccat 4020
aaacaaagac aagtggccac tctttttttt gaaattgtgg agtgggggca cgcgtcagcc 4080
cccacacgcc gccctgcggt tttggactgt aaaataaggg tgtaataact tggctgattg 4140
taaccccgct aaccactgcg gtcaaaccac ttgcccacaa aaccactaat ggcaccccgg 4200
ggaatacctg cataagtagg tgggcgggcc aagatagggg cgcgattgct gcgatctgga 4260
ggacaaatta cacacacttg cgcctgagcg ccaagcacag ggttgttggt cctcatattc 4320
acgaggtcgc tgagagcacg gtgggctaat gttgccatgg gtagcatata ctacccaaat 4380
atctggatag catatgctat cctaatctat atctgggtag cataggctat cctaatctat 4440
atctgggtag catatgctat cctaatctat atctgggtag tatatgctat cctaatttat 4500
atctgggtag cataggctat cctaatctat atctgggtag catatgctat cctaatctat 4560
atctgggtag tatatgctat cctaatctgt atccgggtag catatgctat cctaatagag 4620
attagggtag tatatgctat cctaatttat atctgggtag catatactac ccaaatatct 4680
ggatagcata tgctatccta atctatatct gggtagcata tgctatccta atctatatct 4740
gggtagcata ggctatccta atctatatct gggtagcata tgctatccta atctatatct 4800
gggtagtata tgctatccta atttatatct gggtagcata ggctatccta atctatatct 4860
gggtagcata tgctatccta atctatatct gggtagtata tgctatccta atctgtatcc 4920
gggtagcata tgctatcctc atgcatatac agtcagcata tgatacccag tagtagagtg 4980
ggagtgctat cctttgcata tgccgccacc tcccaagggg gcgtgaattt tcgctgcttg 5040
tccttttcct gctggttgct cccattctta ggtgaattta aggaggccag gctaaagccg 5100
tcgcatgtct gattgctcac caggtaaatg tcgctaatgt tttccaacgc gagaaggtgt 5160
tgagcgcgga gctgagtgac gtgacaacat gggtatgccc aattgcccca tgttgggagg 5220
acgaaaatgg tgacaagaca gatggccaga aatacaccaa cagcacgcat gatgtctact 5280
ggggatttat tctttagtgc gggggaatac acggctttta atacgattga gggcgtctcc 5340
taacaagtta catcactcct gcccttcctc accctcatct ccatcacctc cttcatctcc 5400
gtcatctccg tcatcaccct ccgcggcagc cccttccacc ataggtggaa accagggagg 5460
caaatctact ccatcgtcaa agctgcacac agtcaccctg atattgcagg taggagcggg 5520
ctttgtcata acaaggtcct taatcgcatc cttcaaaacc tcagcaaata tatgagtttg 5580
taaaaagacc atgaaataac agacaatgga ctcccttagc gggccaggtt gtgggccggg 5640
tccaggggcc attccaaagg ggagacgact caatggtgta agacgacatt gtggaatagc 5700
aagggcagtt cctcgcctta ggttgtaaag ggaggtctta ctacctccat atacgaacac 5760
accggcgacc caagttcctt cgtcggtagt cctttctacg tgactcctag ccaggagagc 5820
tcttaaacct tctgcaatgt tctcaaattt cgggttggaa cctccttgac cacgatgctt 5880
ttccaaacca ccctcctttt ttgcgccctg cctccatcac cctgaccccg gggtccagtg 5940
cttgggcctt ctcctgggtc atctgcgggg ccctgctcta tcgctcccgg gggcacgtca 6000
ggctcaccat ctgggccacc ttcttggtgg tattcaaaat aatcggcttc ccctacaggg 6060
tggaaaaatg gccttctacc tggagggggc ctgcgcggtg gagacccgga tgatgatgac 6120
tgactactgg gactcctggg cctcttttct ccacgtccac gacctctccc cctggctctt 6180
tcacgacttc cccccctggc tctttcacgt cctctacccc ggcggcctcc actacctcct 6240
cgaccccggc ctccactacc tcctcgaccc cggcctccac tgcctcctcg accccggcct 6300
ccacctcctg ctcctgcccc tcctgctcct gcccctcctc ctgctcctgc ccctcctgcc 6360
cctcctgctc ctgcccctcc tgcccctcct gctcctgccc ctcctgcccc tcctgctcct 6420
gcccctcctg cccctcctcc tgctcctgcc cctcctgccc ctcctcctgc tcctgcccct 6480
cctgcccctc ctgctcctgc ccctcctgcc cctcctgctc ctgcccctcc tgcccctcct 6540
gctcctgccc ctcctgctcc tgcccctcct gctcctgccc ctcctgctcc tgcccctcct 6600
gcccctcctg cccctcctcc tgctcctgcc cctcctgctc ctgcccctcc tgcccctcct 6660
gcccctcctg ctcctgcccc tcctcctgct cctgcccctc ctgcccctcc tgcccctcct 6720
cctgctcctg cccctcctgc ccctcctcct gctcctgccc ctcctcctgc tcctgcccct 6780
cctgcccctc ctgcccctcc tcctgctcct gcccctcctg cccctcctcc tgctcctgcc 6840
cctcctcctg ctcctgcccc tcctgcccct cctgcccctc ctcctgctcc tgcccctcct 6900
cctgctcctg cccctcctgc ccctcctgcc cctcctgccc ctcctcctgc tcctgcccct 6960
cctcctgctc ctgcccctcc tgctcctgcc cctcccgctc ctgctcctgc tcctgttcca 7020
ccgtgggtcc ctttgcagcc aatgcaactt ggacgttttt ggggtctccg gacaccatct 7080
ctatgtcttg gccctgatcc tgagccgccc ggggctcctg gtcttccgcc tcctcgtcct 7140
cgtcctcttc cccgtcctcg tccatggtta tcaccccctc ttctttgagg tccactgccg 7200
ccggagcctt ctggtccaga tgtgtctccc ttctctccta ggccatttcc aggtcctgta 7260
cctggcccct cgtcagacat gattcacact aaaagagatc aatagacatc tttattagac 7320
gacgctcagt gaatacaggg agtgcagact cctgccccct ccaacagccc ccccaccctc 7380
atccccttca tggtcgctgt cagacagatc caggtctgaa aattccccat cctccgaacc 7440
atcctcgtcc tcatcaccaa ttactcgcag cccggaaaac tcccgctgaa catcctcaag 7500
atttgcgtcc tgagcctcaa gccaggcctc aaattcctcg tccccctttt tgctggacgg 7560
tagggatggg gattctcggg acccctcctc ttcctcttca aggtcaccag acagagatgc 7620
tactggggca acggaagaaa agctgggtgc ggcctgtgag gatcagctta tcgatgataa 7680
gctgtcaaac atgagaattc ttgaagacga aagggcctcg tgatacgcct atttttatag 7740
gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg 7800
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga 7860
caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat 7920
ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca 7980
gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc 8040
gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca 8100
atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtgt tgacgccggg 8160
caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca 8220
gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata 8280
accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag 8340
ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg 8400
gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgc agcaatggca 8460
acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta 8520
atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct 8580
ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca 8640
gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag 8700
gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat 8760
tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt 8820
taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa 8880
cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 8940
gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 9000
gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 9060
agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 9120
aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 9180
agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 9240
cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 9300
accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 9360
aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 9420
ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 9480
cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 9540
gcctttttac ggttcctggc cttttgctgg ccttgaagct gtccctgatg gtcgtcatct 9600
acctgcctgg acagcatggc ctgcaacgcg ggcatcccga tgccgccgga agcgagaaga 9660
atcataatgg ggaaggccat ccagcctcgc gtcgcgaacg ccagcaagac gtagcccagc 9720
gcgtcggccc cgagatgcgc cgcgtgcggc tgctggagat ggcggacgcg atggatatgt 9780
tctgccaagg gttggtttgc gcattcacag ttctccgcaa gaattgattg gctccaattc 9840
ttggagtggt gaatccgtta gcgaggtgcc gccctgcttc atccccgtgg cccgttgctc 9900
gcgtttgctg gcggtgtccc cggaagaaat atatttgcat gtctttagtt ctatgatgac 9960
acaaaccccg cccagcgtct tgtcattggc gaattcgaac acgcagatgc agtcggggcg 10020
gcgcggtccg aggtccactt cgcatattaa ggtgacgcgt gtggcctcga acaccgagcg 10080
accctgcagc gacccgctta acagcgtcaa cagcgtgccg cagatcccgg ggggcaatga 10140
gatatgaaaa agcctgaact caccgcgacg tctgtcgaga agtttctgat cgaaaagttc 10200
gacagcgtct ccgacctgat gcagctctcg gagggcgaag aatctcgtgc tttcagcttc 10260
gatgtaggag ggcgtggata tgtcctgcgg gtaaatagct gcgccgatgg tttctacaaa 10320
gatcgttatg tttatcggca ctttgcatcg gccgcgctcc cgattccgga agtgcttgac 10380
attggggaat tcagcgagag cctgacctat tgcatctccc gccgtgcaca gggtgtcacg 10440
ttgcaagacc tgcctgaaac cgaactgccc gctgttctgc agccggtcgc ggaggccatg 10500
gatgcgatcg ctgcggccga tcttagccag acgagcgggt tcggcccatt cggaccgcaa 10560
ggaatcggtc aatacactac atggcgtgat ttcatatgcg cgattgctga tccccatgtg 10620
tatcactggc aaactgtgat ggacgacacc gtcagtgcgt ccgtcgcgca ggctctcgat 10680
gagctgatgc tttgggccga ggactgcccc gaagtccggc acctcgtgca cgcggatttc 10740
ggctccaaca atgtcctgac ggacaatggc cgcataacag cggtcattga ctggagcgag 10800
gcgatgttcg gggattccca atacgaggtc gccaacatct tcttctggag gccgtggttg 10860
gcttgtatgg agcagcagac gcgctacttc gagcggaggc atccggagct tgcaggatcg 10920
ccgcggctcc gggcgtatat gctccgcatt ggtcttgacc aactctatca gagcttggtt 10980
gacggcaatt tcgatgatgc agcttgggcg cagggtcgat gcgacgcaat cgtccgatcc 11040
ggagccggga ctgtcgggcg tacacaaatc gcccgcagaa gcgcggccgt ctggaccgat 11100
ggctgtgtag aagtactcgc cgatagtgga aaccgacgcc ccagcactcg tccggatcgg 11160
gagatggggg aggctaactg aaacacggaa ggagacaata ccggaaggaa cccgcgctat 11220
gacggcaata aaaagacaga ataaaacgca cgggtgttgg gtcgtttgtt cataaacgcg 11280
gggttcggtc ccagggctgg cactctgtcg ataccccacc gagaccccat tggggccaat 11340
acgcccgcgt ttcttccttt tccccacccc accccccaag ttcgggtgaa ggcccagggc 11400
tcgcagccaa cgtcggggcg gcaggccctg ccatagccac tggccccgtg ggttagggac 11460
ggggtccccc atggggaatg gtttatggtt cgtgggggtt attattttgg gcgttgcgtg 11520
gggtcaggtc cacgactgga ctgagcagac agacccatgg tttttggatg gcctgggcat 11580
ggaccgcatg tactggcgcg acacgaacac cgggcgtctg tggctgccaa acacccccga 11640
cccccaaaaa ccaccgcgcg gatttctggc gtgccaagct agtcgaccaa ttctcatgtt 11700
tgacagctta tcatcgcaga tccgggcaac gttgttgcca ttgctgcagg cgcagaactg 11760
gtaggtatgg aagatctata cattgaatca atattggcaa ttagccatat tagtcattgg 11820
ttatatagca taaatcaata ttggctattg gccattgcat acgttgtatc tatatcataa 11880
tatgtacatt tatattggct catgtccaat atgaccgcca t                     11921



<210> 226
<211> 744
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3391).

<400> 226
cagatccagt cctactcctg cgagcacttc cgctggtgca agccggtggg aggcggagga 60
agcggcggag gcggatcctg cccaccgtgc ccagcacctg aactcctggg gggaccgtca 120
gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 180
acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 240
gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 300
taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 360
aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 420
aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 480
aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 540
gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 600
tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag 660
gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 720
agcctctccc tgtctctggg taaa                                        744

<210> 227
<211> 248
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3391).

<400> 227
Gln Ile Gln Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys Pro Val
 1               5                  10                  15      
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala
            20                  25                  30          
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
        35                  40                  45              
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
    50                  55                  60                  
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
65                  70                  75                  80  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
                85                  90                  95      
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
            100                 105                 110         
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
        115                 120                 125             
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
    130                 135                 140                 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
145                 150                 155                 160 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                165                 170                 175     
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
            180                 185                 190         
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
        195                 200                 205             
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
    210                 215                 220                 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
225                 230                 235                 240 
Ser Leu Ser Leu Ser Leu Gly Lys
                245             


<210> 228
<211> 801
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal and V1 (p3391).

<400> 228
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcccag 60
atccagtcct actcctgcga gcacttccgc tggtgcaagc cggtgggagg cggaggaagc 120
ggcggaggcg gatcctgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc 180
ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 240
tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 300
ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 360
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 420
tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 480
gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag 540
aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 600
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 660
gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg 720
aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 780
ctctccctgt ctctgggtaa a                                           801

<210> 229
<211> 267
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal and V1 encoded by an in
      vitro synthesized DNA (p3391).

<400> 229
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Gln Ile Gln Ser Tyr Ser Cys Glu His Phe Arg Trp Cys
            20                  25                  30          
Lys Pro Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro
        35                  40                  45              
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
    50                  55                  60                  
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
65                  70                  75                  80  
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
                85                  90                  95      
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
            100                 105                 110         
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
        115                 120                 125             
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
    130                 135                 140                 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
145                 150                 155                 160 
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
                165                 170                 175     
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            180                 185                 190         
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        195                 200                 205             
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    210                 215                 220                 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
225                 230                 235                 240 
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                245                 250                 255     
Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
            260                 265         


<210> 230
<211> 11936
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3391).

<400> 230
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcccag atccagtcct actcctgcga 1680
gcacttccgc tggtgcaagc cggtgggagg cggaggaagc ggcggaggcg gatcctgccc 1740
accgtgccca gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc 1800
caaggacacc ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag 1860
ccacgaagac cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc 1920
caagacaaag ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac 1980
cgtcctgcac caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc 2040
cctcccagcc cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca 2100
ggtgtacacc ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg 2160
cctggtcaaa ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc 2220
ggagaacaac tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta 2280
cagcaagctc accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt 2340
gatgcatgag gctctgcaca accactacac gcagaagagc ctctccctgt ctctgggtaa 2400
atgagggccc gtttaaacag atccagacat gataagatac attgatgagt ttggacaaac 2460
cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt 2520
atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat 2580
gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg 2640
tggtatggct gattatgatc cggctgcctc gcgcgtttcg gtgatgacgg tgaaaacctc 2700
tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc cgggagcaga 2760
caagcccgtc aggcgtcagc gggtgttggc gggtgtcggg gcgcagccat gaggtcgact 2820
ctagaggatc gatgccccgc cccggacgaa ctaaacctga ctacgacatc tctgcccctt 2880
cttcgcgggg cagtgcatgt aatcccttca gttggttggt acaacttgcc aactgggccc 2940
tgttccacat gtgacacggg gggggaccaa acacaaaggg gttctctgac tgtagttgac 3000
atccttataa atggatgtgc acatttgcca acactgagtg gctttcatcc tggagcagac 3060
tttgcagtct gtggactgca acacaacatt gcctttatgt gtaactcttg gctgaagctc 3120
ttacaccaat gctgggggac atgtacctcc caggggccca ggaagactac gggaggctac 3180
accaacgtca atcagagggg cctgtgtagc taccgataag cggaccctca agagggcatt 3240
agcaatagtg tttataaggc ccccttgtta accctaaacg ggtagcatat gcttcccggg 3300
tagtagtata tactatccag actaacccta attcaatagc atatgttacc caacgggaag 3360
catatgctat cgaattaggg ttagtaaaag ggtcctaagg aacagcgata tctcccaccc 3420
catgagctgt cacggtttta tttacatggg gtcaggattc cacgagggta gtgaaccatt 3480
ttagtcacaa gggcagtggc tgaagatcaa ggagcgggca gtgaactctc ctgaatcttc 3540
gcctgcttct tcattctcct tcgtttagct aatagaataa ctgctgagtt gtgaacagta 3600
aggtgtatgt gaggtgctcg aaaacaaggt ttcaggtgac gcccccagaa taaaatttgg 3660
acggggggtt cagtggtggc attgtgctat gacaccaata taaccctcac aaaccccttg 3720
ggcaataaat actagtgtag gaatgaaaca ttctgaatat ctttaacaat agaaatccat 3780
ggggtgggga caagccgtaa agactggatg tccatctcac acgaatttat ggctatgggc 3840
aacacataat cctagtgcaa tatgatactg gggttattaa gatgtgtccc aggcagggac 3900
caagacaggt gaaccatgtt gttacactct atttgtaaca aggggaaaga gagtggacgc 3960
cgacagcagc ggactccact ggttgtctct aacacccccg aaaattaaac ggggctccac 4020
gccaatgggg cccataaaca aagacaagtg gccactcttt tttttgaaat tgtggagtgg 4080
gggcacgcgt cagcccccac acgccgccct gcggttttgg actgtaaaat aagggtgtaa 4140
taacttggct gattgtaacc ccgctaacca ctgcggtcaa accacttgcc cacaaaacca 4200
ctaatggcac cccggggaat acctgcataa gtaggtgggc gggccaagat aggggcgcga 4260
ttgctgcgat ctggaggaca aattacacac acttgcgcct gagcgccaag cacagggttg 4320
ttggtcctca tattcacgag gtcgctgaga gcacggtggg ctaatgttgc catgggtagc 4380
atatactacc caaatatctg gatagcatat gctatcctaa tctatatctg ggtagcatag 4440
gctatcctaa tctatatctg ggtagcatat gctatcctaa tctatatctg ggtagtatat 4500
gctatcctaa tttatatctg ggtagcatag gctatcctaa tctatatctg ggtagcatat 4560
gctatcctaa tctatatctg ggtagtatat gctatcctaa tctgtatccg ggtagcatat 4620
gctatcctaa tagagattag ggtagtatat gctatcctaa tttatatctg ggtagcatat 4680
actacccaaa tatctggata gcatatgcta tcctaatcta tatctgggta gcatatgcta 4740
tcctaatcta tatctgggta gcataggcta tcctaatcta tatctgggta gcatatgcta 4800
tcctaatcta tatctgggta gtatatgcta tcctaattta tatctgggta gcataggcta 4860
tcctaatcta tatctgggta gcatatgcta tcctaatcta tatctgggta gtatatgcta 4920
tcctaatctg tatccgggta gcatatgcta tcctcatgca tatacagtca gcatatgata 4980
cccagtagta gagtgggagt gctatccttt gcatatgccg ccacctccca agggggcgtg 5040
aattttcgct gcttgtcctt ttcctgctgg ttgctcccat tcttaggtga atttaaggag 5100
gccaggctaa agccgtcgca tgtctgattg ctcaccaggt aaatgtcgct aatgttttcc 5160
aacgcgagaa ggtgttgagc gcggagctga gtgacgtgac aacatgggta tgcccaattg 5220
ccccatgttg ggaggacgaa aatggtgaca agacagatgg ccagaaatac accaacagca 5280
cgcatgatgt ctactgggga tttattcttt agtgcggggg aatacacggc ttttaatacg 5340
attgagggcg tctcctaaca agttacatca ctcctgccct tcctcaccct catctccatc 5400
acctccttca tctccgtcat ctccgtcatc accctccgcg gcagcccctt ccaccatagg 5460
tggaaaccag ggaggcaaat ctactccatc gtcaaagctg cacacagtca ccctgatatt 5520
gcaggtagga gcgggctttg tcataacaag gtccttaatc gcatccttca aaacctcagc 5580
aaatatatga gtttgtaaaa agaccatgaa ataacagaca atggactccc ttagcgggcc 5640
aggttgtggg ccgggtccag gggccattcc aaaggggaga cgactcaatg gtgtaagacg 5700
acattgtgga atagcaaggg cagttcctcg ccttaggttg taaagggagg tcttactacc 5760
tccatatacg aacacaccgg cgacccaagt tccttcgtcg gtagtccttt ctacgtgact 5820
cctagccagg agagctctta aaccttctgc aatgttctca aatttcgggt tggaacctcc 5880
ttgaccacga tgcttttcca aaccaccctc cttttttgcg ccctgcctcc atcaccctga 5940
ccccggggtc cagtgcttgg gccttctcct gggtcatctg cggggccctg ctctatcgct 6000
cccgggggca cgtcaggctc accatctggg ccaccttctt ggtggtattc aaaataatcg 6060
gcttccccta cagggtggaa aaatggcctt ctacctggag ggggcctgcg cggtggagac 6120
ccggatgatg atgactgact actgggactc ctgggcctct tttctccacg tccacgacct 6180
ctccccctgg ctctttcacg acttcccccc ctggctcttt cacgtcctct accccggcgg 6240
cctccactac ctcctcgacc ccggcctcca ctacctcctc gaccccggcc tccactgcct 6300
cctcgacccc ggcctccacc tcctgctcct gcccctcctg ctcctgcccc tcctcctgct 6360
cctgcccctc ctgcccctcc tgctcctgcc cctcctgccc ctcctgctcc tgcccctcct 6420
gcccctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6480
cctgctcctg cccctcctgc ccctcctgct cctgcccctc ctgcccctcc tgctcctgcc 6540
cctcctgccc ctcctgctcc tgcccctcct gctcctgccc ctcctgctcc tgcccctcct 6600
gctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tgctcctgcc 6660
cctcctgccc ctcctgcccc tcctgctcct gcccctcctc ctgctcctgc ccctcctgcc 6720
cctcctgccc ctcctcctgc tcctgcccct cctgcccctc ctcctgctcc tgcccctcct 6780
cctgctcctg cccctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctgcccct 6840
cctcctgctc ctgcccctcc tcctgctcct gcccctcctg cccctcctgc ccctcctcct 6900
gctcctgccc ctcctcctgc tcctgcccct cctgcccctc ctgcccctcc tgcccctcct 6960
cctgctcctg cccctcctcc tgctcctgcc cctcctgctc ctgcccctcc cgctcctgct 7020
cctgctcctg ttccaccgtg ggtccctttg cagccaatgc aacttggacg tttttggggt 7080
ctccggacac catctctatg tcttggccct gatcctgagc cgcccggggc tcctggtctt 7140
ccgcctcctc gtcctcgtcc tcttccccgt cctcgtccat ggttatcacc ccctcttctt 7200
tgaggtccac tgccgccgga gccttctggt ccagatgtgt ctcccttctc tcctaggcca 7260
tttccaggtc ctgtacctgg cccctcgtca gacatgattc acactaaaag agatcaatag 7320
acatctttat tagacgacgc tcagtgaata cagggagtgc agactcctgc cccctccaac 7380
agccccccca ccctcatccc cttcatggtc gctgtcagac agatccaggt ctgaaaattc 7440
cccatcctcc gaaccatcct cgtcctcatc accaattact cgcagcccgg aaaactcccg 7500
ctgaacatcc tcaagatttg cgtcctgagc ctcaagccag gcctcaaatt cctcgtcccc 7560
ctttttgctg gacggtaggg atggggattc tcgggacccc tcctcttcct cttcaaggtc 7620
accagacaga gatgctactg gggcaacgga agaaaagctg ggtgcggcct gtgaggatca 7680
gcttatcgat gataagctgt caaacatgag aattcttgaa gacgaaaggg cctcgtgata 7740
cgcctatttt tataggttaa tgtcatgata ataatggttt cttagacgtc aggtggcact 7800
tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg 7860
tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt 7920
atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct 7980
gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca 8040
cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc 8100
gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc 8160
cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg 8220
gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta 8280
tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc 8340
ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt 8400
gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg 8460
cctgcagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct 8520
tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc 8580
tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct 8640
cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac 8700
acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc 8760
tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat 8820
ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg 8880
accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc 8940
aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa 9000
ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag 9060
gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta 9120
ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta 9180
ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag 9240
ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg 9300
gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg 9360
cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag 9420
cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc 9480
cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa 9540
aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttg aagctgtccc 9600
tgatggtcgt catctacctg cctggacagc atggcctgca acgcgggcat cccgatgccg 9660
ccggaagcga gaagaatcat aatggggaag gccatccagc ctcgcgtcgc gaacgccagc 9720
aagacgtagc ccagcgcgtc ggccccgaga tgcgccgcgt gcggctgctg gagatggcgg 9780
acgcgatgga tatgttctgc caagggttgg tttgcgcatt cacagttctc cgcaagaatt 9840
gattggctcc aattcttgga gtggtgaatc cgttagcgag gtgccgccct gcttcatccc 9900
cgtggcccgt tgctcgcgtt tgctggcggt gtccccggaa gaaatatatt tgcatgtctt 9960
tagttctatg atgacacaaa ccccgcccag cgtcttgtca ttggcgaatt cgaacacgca 10020
gatgcagtcg gggcggcgcg gtccgaggtc cacttcgcat attaaggtga cgcgtgtggc 10080
ctcgaacacc gagcgaccct gcagcgaccc gcttaacagc gtcaacagcg tgccgcagat 10140
cccggggggc aatgagatat gaaaaagcct gaactcaccg cgacgtctgt cgagaagttt 10200
ctgatcgaaa agttcgacag cgtctccgac ctgatgcagc tctcggaggg cgaagaatct 10260
cgtgctttca gcttcgatgt aggagggcgt ggatatgtcc tgcgggtaaa tagctgcgcc 10320
gatggtttct acaaagatcg ttatgtttat cggcactttg catcggccgc gctcccgatt 10380
ccggaagtgc ttgacattgg ggaattcagc gagagcctga cctattgcat ctcccgccgt 10440
gcacagggtg tcacgttgca agacctgcct gaaaccgaac tgcccgctgt tctgcagccg 10500
gtcgcggagg ccatggatgc gatcgctgcg gccgatctta gccagacgag cgggttcggc 10560
ccattcggac cgcaaggaat cggtcaatac actacatggc gtgatttcat atgcgcgatt 10620
gctgatcccc atgtgtatca ctggcaaact gtgatggacg acaccgtcag tgcgtccgtc 10680
gcgcaggctc tcgatgagct gatgctttgg gccgaggact gccccgaagt ccggcacctc 10740
gtgcacgcgg atttcggctc caacaatgtc ctgacggaca atggccgcat aacagcggtc 10800
attgactgga gcgaggcgat gttcggggat tcccaatacg aggtcgccaa catcttcttc 10860
tggaggccgt ggttggcttg tatggagcag cagacgcgct acttcgagcg gaggcatccg 10920
gagcttgcag gatcgccgcg gctccgggcg tatatgctcc gcattggtct tgaccaactc 10980
tatcagagct tggttgacgg caatttcgat gatgcagctt gggcgcaggg tcgatgcgac 11040
gcaatcgtcc gatccggagc cgggactgtc gggcgtacac aaatcgcccg cagaagcgcg 11100
gccgtctgga ccgatggctg tgtagaagta ctcgccgata gtggaaaccg acgccccagc 11160
actcgtccgg atcgggagat gggggaggct aactgaaaca cggaaggaga caataccgga 11220
aggaacccgc gctatgacgg caataaaaag acagaataaa acgcacgggt gttgggtcgt 11280
ttgttcataa acgcggggtt cggtcccagg gctggcactc tgtcgatacc ccaccgagac 11340
cccattgggg ccaatacgcc cgcgtttctt ccttttcccc accccacccc ccaagttcgg 11400
gtgaaggccc agggctcgca gccaacgtcg gggcggcagg ccctgccata gccactggcc 11460
ccgtgggtta gggacggggt cccccatggg gaatggttta tggttcgtgg gggttattat 11520
tttgggcgtt gcgtggggtc aggtccacga ctggactgag cagacagacc catggttttt 11580
ggatggcctg ggcatggacc gcatgtactg gcgcgacacg aacaccgggc gtctgtggct 11640
gccaaacacc cccgaccccc aaaaaccacc gcgcggattt ctggcgtgcc aagctagtcg 11700
accaattctc atgtttgaca gcttatcatc gcagatccgg gcaacgttgt tgccattgct 11760
gcaggcgcag aactggtagg tatggaagat ctatacattg aatcaatatt ggcaattagc 11820
catattagtc attggttata tagcataaat caatattggc tattggccat tgcatacgtt 11880
gtatctatat cataatatgt acatttatat tggctcatgt ccaatatgac cgccat     11936



<210> 231
<211> 792
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3458).

<400> 231
cagatccagg gaggctccta ctcctgcgag cacttccgct ggtgcaagcc ggtgggatcc 60
ggtggaggct ccggtacctt agtcgccgtc tcctcagagc ccaaatctgc cgacaaaact 120
cacgcctgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc 180
cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 240
gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 300
gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 360
agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc 420
tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 480
cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc 540
agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 600
aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 660
ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 720
tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 780
tctccgggta aa                                                     792

<210> 232
<211> 264
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3458).

<400> 232
Gln Ile Gln Gly Gly Ser Tyr Ser Cys Glu His Phe Arg Trp Cys Lys
 1               5                  10                  15      
Pro Val Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser
            20                  25                  30          
Glu Pro Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala
        35                  40                  45              
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
    50                  55                  60                  
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
65                  70                  75                  80  
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
                85                  90                  95      
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
            100                 105                 110         
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
        115                 120                 125             
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
    130                 135                 140                 
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
145                 150                 155                 160 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
                165                 170                 175     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
            180                 185                 190         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
        195                 200                 205             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
    210                 215                 220                 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
225                 230                 235                 240 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                245                 250                 255     
Ser Leu Ser Leu Ser Pro Gly Lys
            260                 


<210> 233
<211> 849
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal and V1 (p3458).

<400> 233
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcccag 60
atccagggag gctcctactc ctgcgagcac ttccgctggt gcaagccggt gggatccggt 120
ggaggctccg gtaccttagt cgccgtctcc tcagagccca aatctgccga caaaactcac 180
gcctgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc 240
ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 300
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 360
cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 420
gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc 480
aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga 540
gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 600
ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 660
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc 720
ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca 780
tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 840
ccgggtaaa                                                         849

<210> 234
<211> 283
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal and V1 encoded by an in
      vitro synthesized DNA (p3458).

<400> 234
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Gln Ile Gln Gly Gly Ser Tyr Ser Cys Glu His Phe Arg
            20                  25                  30          
Trp Cys Lys Pro Val Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Ala
        35                  40                  45              
Val Ser Ser Glu Pro Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro
    50                  55                  60                  
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
65                  70                  75                  80  
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
                85                  90                  95      
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
            100                 105                 110         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
        115                 120                 125             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
    130                 135                 140                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
145                 150                 155                 160 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
                165                 170                 175     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
            180                 185                 190         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
        195                 200                 205             

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
    210                 215                 220                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
225                 230                 235                 240 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                245                 250                 255     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
            260                 265                 270         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        275                 280             


<210> 235
<211> 11984
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3458).
      
      

<400> 235
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcccag atccagggag gctcctactc 1680
ctgcgagcac ttccgctggt gcaagccggt gggatccggt ggaggctccg gtaccttagt 1740
cgccgtctcc tcagagccca aatctgccga caaaactcac gcctgcccac cgtgcccagc 1800
acctgaactc ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct 1860
catgatctcc cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc 1920
tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc 1980
gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca 2040
ggactggctg aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc 2100
catcgagaaa accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct 2160
gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg 2220
cttctatccc agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta 2280
caagaccacg cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac 2340
cgtggacaag agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc 2400
tctgcacaac cactacacgc agaagagcct ctccctgtct ccgggtaaat gagggcccgt 2460
ttaaacagat ccagacatga taagatacat tgatgagttt ggacaaacca caactagaat 2520
gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat 2580
tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca 2640
gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtatggctga 2700
ttatgatccg gctgcctcgc gcgtttcggt gatgacggtg aaaacctctg acacatgcag 2760
ctcccggaga cggtcacagc ttgtctgtaa gcggatgccg ggagcagaca agcccgtcag 2820
gcgtcagcgg gtgttggcgg gtgtcggggc gcagccatga ggtcgactct agaggatcga 2880
tgccccgccc cggacgaact aaacctgact acgacatctc tgccccttct tcgcggggca 2940
gtgcatgtaa tcccttcagt tggttggtac aacttgccaa ctgggccctg ttccacatgt 3000
gacacggggg gggaccaaac acaaaggggt tctctgactg tagttgacat ccttataaat 3060
ggatgtgcac atttgccaac actgagtggc tttcatcctg gagcagactt tgcagtctgt 3120
ggactgcaac acaacattgc ctttatgtgt aactcttggc tgaagctctt acaccaatgc 3180
tgggggacat gtacctccca ggggcccagg aagactacgg gaggctacac caacgtcaat 3240
cagaggggcc tgtgtagcta ccgataagcg gaccctcaag agggcattag caatagtgtt 3300
tataaggccc ccttgttaac cctaaacggg tagcatatgc ttcccgggta gtagtatata 3360
ctatccagac taaccctaat tcaatagcat atgttaccca acgggaagca tatgctatcg 3420
aattagggtt agtaaaaggg tcctaaggaa cagcgatatc tcccacccca tgagctgtca 3480
cggttttatt tacatggggt caggattcca cgagggtagt gaaccatttt agtcacaagg 3540
gcagtggctg aagatcaagg agcgggcagt gaactctcct gaatcttcgc ctgcttcttc 3600
attctccttc gtttagctaa tagaataact gctgagttgt gaacagtaag gtgtatgtga 3660
ggtgctcgaa aacaaggttt caggtgacgc ccccagaata aaatttggac ggggggttca 3720
gtggtggcat tgtgctatga caccaatata accctcacaa accccttggg caataaatac 3780
tagtgtagga atgaaacatt ctgaatatct ttaacaatag aaatccatgg ggtggggaca 3840
agccgtaaag actggatgtc catctcacac gaatttatgg ctatgggcaa cacataatcc 3900
tagtgcaata tgatactggg gttattaaga tgtgtcccag gcagggacca agacaggtga 3960
accatgttgt tacactctat ttgtaacaag gggaaagaga gtggacgccg acagcagcgg 4020
actccactgg ttgtctctaa cacccccgaa aattaaacgg ggctccacgc caatggggcc 4080
cataaacaaa gacaagtggc cactcttttt tttgaaattg tggagtgggg gcacgcgtca 4140
gcccccacac gccgccctgc ggttttggac tgtaaaataa gggtgtaata acttggctga 4200
ttgtaacccc gctaaccact gcggtcaaac cacttgccca caaaaccact aatggcaccc 4260
cggggaatac ctgcataagt aggtgggcgg gccaagatag gggcgcgatt gctgcgatct 4320
ggaggacaaa ttacacacac ttgcgcctga gcgccaagca cagggttgtt ggtcctcata 4380
ttcacgaggt cgctgagagc acggtgggct aatgttgcca tgggtagcat atactaccca 4440
aatatctgga tagcatatgc tatcctaatc tatatctggg tagcataggc tatcctaatc 4500
tatatctggg tagcatatgc tatcctaatc tatatctggg tagtatatgc tatcctaatt 4560
tatatctggg tagcataggc tatcctaatc tatatctggg tagcatatgc tatcctaatc 4620
tatatctggg tagtatatgc tatcctaatc tgtatccggg tagcatatgc tatcctaata 4680
gagattaggg tagtatatgc tatcctaatt tatatctggg tagcatatac tacccaaata 4740
tctggatagc atatgctatc ctaatctata tctgggtagc atatgctatc ctaatctata 4800
tctgggtagc ataggctatc ctaatctata tctgggtagc atatgctatc ctaatctata 4860
tctgggtagt atatgctatc ctaatttata tctgggtagc ataggctatc ctaatctata 4920
tctgggtagc atatgctatc ctaatctata tctgggtagt atatgctatc ctaatctgta 4980
tccgggtagc atatgctatc ctcatgcata tacagtcagc atatgatacc cagtagtaga 5040
gtgggagtgc tatcctttgc atatgccgcc acctcccaag ggggcgtgaa ttttcgctgc 5100
ttgtcctttt cctgctggtt gctcccattc ttaggtgaat ttaaggaggc caggctaaag 5160
ccgtcgcatg tctgattgct caccaggtaa atgtcgctaa tgttttccaa cgcgagaagg 5220
tgttgagcgc ggagctgagt gacgtgacaa catgggtatg cccaattgcc ccatgttggg 5280
aggacgaaaa tggtgacaag acagatggcc agaaatacac caacagcacg catgatgtct 5340
actggggatt tattctttag tgcgggggaa tacacggctt ttaatacgat tgagggcgtc 5400
tcctaacaag ttacatcact cctgcccttc ctcaccctca tctccatcac ctccttcatc 5460
tccgtcatct ccgtcatcac cctccgcggc agccccttcc accataggtg gaaaccaggg 5520
aggcaaatct actccatcgt caaagctgca cacagtcacc ctgatattgc aggtaggagc 5580
gggctttgtc ataacaaggt ccttaatcgc atccttcaaa acctcagcaa atatatgagt 5640
ttgtaaaaag accatgaaat aacagacaat ggactccctt agcgggccag gttgtgggcc 5700
gggtccaggg gccattccaa aggggagacg actcaatggt gtaagacgac attgtggaat 5760
agcaagggca gttcctcgcc ttaggttgta aagggaggtc ttactacctc catatacgaa 5820
cacaccggcg acccaagttc cttcgtcggt agtcctttct acgtgactcc tagccaggag 5880
agctcttaaa ccttctgcaa tgttctcaaa tttcgggttg gaacctcctt gaccacgatg 5940
cttttccaaa ccaccctcct tttttgcgcc ctgcctccat caccctgacc ccggggtcca 6000
gtgcttgggc cttctcctgg gtcatctgcg gggccctgct ctatcgctcc cgggggcacg 6060
tcaggctcac catctgggcc accttcttgg tggtattcaa aataatcggc ttcccctaca 6120
gggtggaaaa atggccttct acctggaggg ggcctgcgcg gtggagaccc ggatgatgat 6180
gactgactac tgggactcct gggcctcttt tctccacgtc cacgacctct ccccctggct 6240
ctttcacgac ttccccccct ggctctttca cgtcctctac cccggcggcc tccactacct 6300
cctcgacccc ggcctccact acctcctcga ccccggcctc cactgcctcc tcgaccccgg 6360
cctccacctc ctgctcctgc ccctcctgct cctgcccctc ctcctgctcc tgcccctcct 6420
gcccctcctg ctcctgcccc tcctgcccct cctgctcctg cccctcctgc ccctcctgct 6480
cctgcccctc ctgcccctcc tcctgctcct gcccctcctg cccctcctcc tgctcctgcc 6540
cctcctgccc ctcctgctcc tgcccctcct gcccctcctg ctcctgcccc tcctgcccct 6600
cctgctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc tcctgcccct 6660
cctgcccctc ctgcccctcc tcctgctcct gcccctcctg ctcctgcccc tcctgcccct 6720
cctgcccctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgcccct 6780
cctcctgctc ctgcccctcc tgcccctcct cctgctcctg cccctcctcc tgctcctgcc 6840
cctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctgcccctcc tcctgctcct 6900
gcccctcctc ctgctcctgc ccctcctgcc cctcctgccc ctcctcctgc tcctgcccct 6960
cctcctgctc ctgcccctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 7020
cctcctcctg ctcctgcccc tcctgctcct gcccctcccg ctcctgctcc tgctcctgtt 7080
ccaccgtggg tccctttgca gccaatgcaa cttggacgtt tttggggtct ccggacacca 7140
tctctatgtc ttggccctga tcctgagccg cccggggctc ctggtcttcc gcctcctcgt 7200
cctcgtcctc ttccccgtcc tcgtccatgg ttatcacccc ctcttctttg aggtccactg 7260
ccgccggagc cttctggtcc agatgtgtct cccttctctc ctaggccatt tccaggtcct 7320
gtacctggcc cctcgtcaga catgattcac actaaaagag atcaatagac atctttatta 7380
gacgacgctc agtgaataca gggagtgcag actcctgccc cctccaacag cccccccacc 7440
ctcatcccct tcatggtcgc tgtcagacag atccaggtct gaaaattccc catcctccga 7500
accatcctcg tcctcatcac caattactcg cagcccggaa aactcccgct gaacatcctc 7560
aagatttgcg tcctgagcct caagccaggc ctcaaattcc tcgtccccct ttttgctgga 7620
cggtagggat ggggattctc gggacccctc ctcttcctct tcaaggtcac cagacagaga 7680
tgctactggg gcaacggaag aaaagctggg tgcggcctgt gaggatcagc ttatcgatga 7740
taagctgtca aacatgagaa ttcttgaaga cgaaagggcc tcgtgatacg cctattttta 7800
taggttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat 7860
gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg 7920
agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa 7980
catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac 8040
ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac 8100
atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt 8160
ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tgttgacgcc 8220
gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca 8280
ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc 8340
ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag 8400
gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa 8460
ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgcagcaatg 8520
gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa 8580
ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg 8640
gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt 8700
gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt 8760
caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag 8820
cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat 8880
ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct 8940
taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct 9000
tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca 9060
gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc 9120
agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc 9180
aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct 9240
gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag 9300
gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc 9360
tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg 9420
agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag 9480
cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt 9540
gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac 9600
gcggcctttt tacggttcct ggccttttgc tggccttgaa gctgtccctg atggtcgtca 9660
tctacctgcc tggacagcat ggcctgcaac gcgggcatcc cgatgccgcc ggaagcgaga 9720
agaatcataa tggggaaggc catccagcct cgcgtcgcga acgccagcaa gacgtagccc 9780
agcgcgtcgg ccccgagatg cgccgcgtgc ggctgctgga gatggcggac gcgatggata 9840
tgttctgcca agggttggtt tgcgcattca cagttctccg caagaattga ttggctccaa 9900
ttcttggagt ggtgaatccg ttagcgaggt gccgccctgc ttcatccccg tggcccgttg 9960
ctcgcgtttg ctggcggtgt ccccggaaga aatatatttg catgtcttta gttctatgat 10020
gacacaaacc ccgcccagcg tcttgtcatt ggcgaattcg aacacgcaga tgcagtcggg 10080
gcggcgcggt ccgaggtcca cttcgcatat taaggtgacg cgtgtggcct cgaacaccga 10140
gcgaccctgc agcgacccgc ttaacagcgt caacagcgtg ccgcagatcc cggggggcaa 10200
tgagatatga aaaagcctga actcaccgcg acgtctgtcg agaagtttct gatcgaaaag 10260
ttcgacagcg tctccgacct gatgcagctc tcggagggcg aagaatctcg tgctttcagc 10320
ttcgatgtag gagggcgtgg atatgtcctg cgggtaaata gctgcgccga tggtttctac 10380
aaagatcgtt atgtttatcg gcactttgca tcggccgcgc tcccgattcc ggaagtgctt 10440
gacattgggg aattcagcga gagcctgacc tattgcatct cccgccgtgc acagggtgtc 10500
acgttgcaag acctgcctga aaccgaactg cccgctgttc tgcagccggt cgcggaggcc 10560
atggatgcga tcgctgcggc cgatcttagc cagacgagcg ggttcggccc attcggaccg 10620
caaggaatcg gtcaatacac tacatggcgt gatttcatat gcgcgattgc tgatccccat 10680
gtgtatcact ggcaaactgt gatggacgac accgtcagtg cgtccgtcgc gcaggctctc 10740
gatgagctga tgctttgggc cgaggactgc cccgaagtcc ggcacctcgt gcacgcggat 10800
ttcggctcca acaatgtcct gacggacaat ggccgcataa cagcggtcat tgactggagc 10860
gaggcgatgt tcggggattc ccaatacgag gtcgccaaca tcttcttctg gaggccgtgg 10920
ttggcttgta tggagcagca gacgcgctac ttcgagcgga ggcatccgga gcttgcagga 10980
tcgccgcggc tccgggcgta tatgctccgc attggtcttg accaactcta tcagagcttg 11040
gttgacggca atttcgatga tgcagcttgg gcgcagggtc gatgcgacgc aatcgtccga 11100
tccggagccg ggactgtcgg gcgtacacaa atcgcccgca gaagcgcggc cgtctggacc 11160
gatggctgtg tagaagtact cgccgatagt ggaaaccgac gccccagcac tcgtccggat 11220
cgggagatgg gggaggctaa ctgaaacacg gaaggagaca ataccggaag gaacccgcgc 11280
tatgacggca ataaaaagac agaataaaac gcacgggtgt tgggtcgttt gttcataaac 11340
gcggggttcg gtcccagggc tggcactctg tcgatacccc accgagaccc cattggggcc 11400
aatacgcccg cgtttcttcc ttttccccac cccacccccc aagttcgggt gaaggcccag 11460
ggctcgcagc caacgtcggg gcggcaggcc ctgccatagc cactggcccc gtgggttagg 11520
gacggggtcc cccatgggga atggtttatg gttcgtgggg gttattattt tgggcgttgc 11580
gtggggtcag gtccacgact ggactgagca gacagaccca tggtttttgg atggcctggg 11640
catggaccgc atgtactggc gcgacacgaa caccgggcgt ctgtggctgc caaacacccc 11700
cgacccccaa aaaccaccgc gcggatttct ggcgtgccaa gctagtcgac caattctcat 11760
gtttgacagc ttatcatcgc agatccgggc aacgttgttg ccattgctgc aggcgcagaa 11820
ctggtaggta tggaagatct atacattgaa tcaatattgg caattagcca tattagtcat 11880
tggttatata gcataaatca atattggcta ttggccattg catacgttgt atctatatca 11940
taatatgtac atttatattg gctcatgtcc aatatgaccg ccat                  11984



<210> 236
<211> 798
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3459).
      

<400> 236
cagatccagg gaggcggagg ctcctactcc tgcgagcact tccgctggtg caagccggtg 60
ggatccggtg gaggctccgg taccttagtc gccgtctcct cagagcccaa atctgccgac 120
aaaactcacg cctgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc 180
ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 240
gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 300
gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt 360
gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 420
aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 480
cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac 540
caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 600
gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 660
ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac 720
gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 780
tccctgtctc cgggtaaa                                               798

<210> 237
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3459).
      

<400> 237
Gln Ile Gln Gly Gly Gly Gly Ser Tyr Ser Cys Glu His Phe Arg Trp
 1               5                  10                  15      
Cys Lys Pro Val Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Ala Val
            20                  25                  30          
Ser Ser Glu Pro Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro Cys
        35                  40                  45              
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
    50                  55                  60                  
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
65                  70                  75                  80  
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
                85                  90                  95      
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
            100                 105                 110         
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
        115                 120                 125             
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
    130                 135                 140                 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
145                 150                 155                 160 

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
                165                 170                 175     
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
            180                 185                 190         
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
        195                 200                 205             
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
    210                 215                 220                 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
225                 230                 235                 240 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
                245                 250                 255     
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            260                 265     


<210> 238
<211> 855
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal and V1 (p3459).
      

<400> 238
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcccag 60
atccagggag gcggaggctc ctactcctgc gagcacttcc gctggtgcaa gccggtggga 120
tccggtggag gctccggtac cttagtcgcc gtctcctcag agcccaaatc tgccgacaaa 180
actcacgcct gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc 240
ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg 300
gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg 360
gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg 420
gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag 480
gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag 540
ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag 600
gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag 660
agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc 720
tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc 780
ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc 840
ctgtctccgg gtaaa                                                  855

<210> 239
<211> 285
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal and V1 encoded by an in
      vitro synthesized DNA (p3459).
      

<400> 239

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Gln Ile Gln Gly Gly Gly Gly Ser Tyr Ser Cys Glu His
            20                  25                  30          
Phe Arg Trp Cys Lys Pro Val Gly Ser Gly Gly Gly Ser Gly Thr Leu
        35                  40                  45              
Val Ala Val Ser Ser Glu Pro Lys Ser Ala Asp Lys Thr His Ala Cys
    50                  55                  60                  
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
65                  70                  75                  80  
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
                85                  90                  95      
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
            100                 105                 110         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
        115                 120                 125             
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
    130                 135                 140                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
145                 150                 155                 160 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
                165                 170                 175     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
            180                 185                 190         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
        195                 200                 205             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
    210                 215                 220                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
225                 230                 235                 240 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
                245                 250                 255     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
            260                 265                 270         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        275                 280                 285 


<210> 240
<211> 11990
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3459).
      

<400> 240
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcccag atccagggag gcggaggctc 1680
ctactcctgc gagcacttcc gctggtgcaa gccggtggga tccggtggag gctccggtac 1740
cttagtcgcc gtctcctcag agcccaaatc tgccgacaaa actcacgcct gcccaccgtg 1800
cccagcacct gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga 1860
caccctcatg atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga 1920
agaccctgag gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac 1980
aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct 2040
gcaccaggac tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc 2100
agcccccatc gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta 2160
caccctgccc ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt 2220
caaaggcttc tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa 2280
caactacaag accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa 2340
gctcaccgtg gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca 2400
tgaggctctg cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatgagg 2460
gcccgtttaa acagatccag acatgataag atacattgat gagtttggac aaaccacaac 2520
tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt 2580
aaccattata agctgcaata aacaagttaa caacaacaat tgcattcatt ttatgtttca 2640
ggttcagggg gaggtgtggg aggtttttta aagcaagtaa aacctctaca aatgtggtat 2700
ggctgattat gatccggctg cctcgcgcgt ttcggtgatg acggtgaaaa cctctgacac 2760
atgcagctcc cggagacggt cacagcttgt ctgtaagcgg atgccgggag cagacaagcc 2820
cgtcaggcgt cagcgggtgt tggcgggtgt cggggcgcag ccatgaggtc gactctagag 2880
gatcgatgcc ccgccccgga cgaactaaac ctgactacga catctctgcc ccttcttcgc 2940
ggggcagtgc atgtaatccc ttcagttggt tggtacaact tgccaactgg gccctgttcc 3000
acatgtgaca cgggggggga ccaaacacaa aggggttctc tgactgtagt tgacatcctt 3060
ataaatggat gtgcacattt gccaacactg agtggctttc atcctggagc agactttgca 3120
gtctgtggac tgcaacacaa cattgccttt atgtgtaact cttggctgaa gctcttacac 3180
caatgctggg ggacatgtac ctcccagggg cccaggaaga ctacgggagg ctacaccaac 3240
gtcaatcaga ggggcctgtg tagctaccga taagcggacc ctcaagaggg cattagcaat 3300
agtgtttata aggccccctt gttaacccta aacgggtagc atatgcttcc cgggtagtag 3360
tatatactat ccagactaac cctaattcaa tagcatatgt tacccaacgg gaagcatatg 3420
ctatcgaatt agggttagta aaagggtcct aaggaacagc gatatctccc accccatgag 3480
ctgtcacggt tttatttaca tggggtcagg attccacgag ggtagtgaac cattttagtc 3540
acaagggcag tggctgaaga tcaaggagcg ggcagtgaac tctcctgaat cttcgcctgc 3600
ttcttcattc tccttcgttt agctaataga ataactgctg agttgtgaac agtaaggtgt 3660
atgtgaggtg ctcgaaaaca aggtttcagg tgacgccccc agaataaaat ttggacgggg 3720
ggttcagtgg tggcattgtg ctatgacacc aatataaccc tcacaaaccc cttgggcaat 3780
aaatactagt gtaggaatga aacattctga atatctttaa caatagaaat ccatggggtg 3840
gggacaagcc gtaaagactg gatgtccatc tcacacgaat ttatggctat gggcaacaca 3900
taatcctagt gcaatatgat actggggtta ttaagatgtg tcccaggcag ggaccaagac 3960
aggtgaacca tgttgttaca ctctatttgt aacaagggga aagagagtgg acgccgacag 4020
cagcggactc cactggttgt ctctaacacc cccgaaaatt aaacggggct ccacgccaat 4080
ggggcccata aacaaagaca agtggccact cttttttttg aaattgtgga gtgggggcac 4140
gcgtcagccc ccacacgccg ccctgcggtt ttggactgta aaataagggt gtaataactt 4200
ggctgattgt aaccccgcta accactgcgg tcaaaccact tgcccacaaa accactaatg 4260
gcaccccggg gaatacctgc ataagtaggt gggcgggcca agataggggc gcgattgctg 4320
cgatctggag gacaaattac acacacttgc gcctgagcgc caagcacagg gttgttggtc 4380
ctcatattca cgaggtcgct gagagcacgg tgggctaatg ttgccatggg tagcatatac 4440
tacccaaata tctggatagc atatgctatc ctaatctata tctgggtagc ataggctatc 4500
ctaatctata tctgggtagc atatgctatc ctaatctata tctgggtagt atatgctatc 4560
ctaatttata tctgggtagc ataggctatc ctaatctata tctgggtagc atatgctatc 4620
ctaatctata tctgggtagt atatgctatc ctaatctgta tccgggtagc atatgctatc 4680
ctaatagaga ttagggtagt atatgctatc ctaatttata tctgggtagc atatactacc 4740
caaatatctg gatagcatat gctatcctaa tctatatctg ggtagcatat gctatcctaa 4800
tctatatctg ggtagcatag gctatcctaa tctatatctg ggtagcatat gctatcctaa 4860
tctatatctg ggtagtatat gctatcctaa tttatatctg ggtagcatag gctatcctaa 4920
tctatatctg ggtagcatat gctatcctaa tctatatctg ggtagtatat gctatcctaa 4980
tctgtatccg ggtagcatat gctatcctca tgcatataca gtcagcatat gatacccagt 5040
agtagagtgg gagtgctatc ctttgcatat gccgccacct cccaaggggg cgtgaatttt 5100
cgctgcttgt ccttttcctg ctggttgctc ccattcttag gtgaatttaa ggaggccagg 5160
ctaaagccgt cgcatgtctg attgctcacc aggtaaatgt cgctaatgtt ttccaacgcg 5220
agaaggtgtt gagcgcggag ctgagtgacg tgacaacatg ggtatgccca attgccccat 5280
gttgggagga cgaaaatggt gacaagacag atggccagaa atacaccaac agcacgcatg 5340
atgtctactg gggatttatt ctttagtgcg ggggaataca cggcttttaa tacgattgag 5400
ggcgtctcct aacaagttac atcactcctg cccttcctca ccctcatctc catcacctcc 5460
ttcatctccg tcatctccgt catcaccctc cgcggcagcc ccttccacca taggtggaaa 5520
ccagggaggc aaatctactc catcgtcaaa gctgcacaca gtcaccctga tattgcaggt 5580
aggagcgggc tttgtcataa caaggtcctt aatcgcatcc ttcaaaacct cagcaaatat 5640
atgagtttgt aaaaagacca tgaaataaca gacaatggac tcccttagcg ggccaggttg 5700
tgggccgggt ccaggggcca ttccaaaggg gagacgactc aatggtgtaa gacgacattg 5760
tggaatagca agggcagttc ctcgccttag gttgtaaagg gaggtcttac tacctccata 5820
tacgaacaca ccggcgaccc aagttccttc gtcggtagtc ctttctacgt gactcctagc 5880
caggagagct cttaaacctt ctgcaatgtt ctcaaatttc gggttggaac ctccttgacc 5940
acgatgcttt tccaaaccac cctccttttt tgcgccctgc ctccatcacc ctgaccccgg 6000
ggtccagtgc ttgggccttc tcctgggtca tctgcggggc cctgctctat cgctcccggg 6060
ggcacgtcag gctcaccatc tgggccacct tcttggtggt attcaaaata atcggcttcc 6120
cctacagggt ggaaaaatgg ccttctacct ggagggggcc tgcgcggtgg agacccggat 6180
gatgatgact gactactggg actcctgggc ctcttttctc cacgtccacg acctctcccc 6240
ctggctcttt cacgacttcc ccccctggct ctttcacgtc ctctaccccg gcggcctcca 6300
ctacctcctc gaccccggcc tccactacct cctcgacccc ggcctccact gcctcctcga 6360
ccccggcctc cacctcctgc tcctgcccct cctgctcctg cccctcctcc tgctcctgcc 6420
cctcctgccc ctcctgctcc tgcccctcct gcccctcctg ctcctgcccc tcctgcccct 6480
cctgctcctg cccctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctcctgct 6540
cctgcccctc ctgcccctcc tgctcctgcc cctcctgccc ctcctgctcc tgcccctcct 6600
gcccctcctg ctcctgcccc tcctgctcct gcccctcctg ctcctgcccc tcctgctcct 6660
gcccctcctg cccctcctgc ccctcctcct gctcctgccc ctcctgctcc tgcccctcct 6720
gcccctcctg cccctcctgc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6780
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6840
cctgcccctc ctgcccctcc tgcccctcct cctgctcctg cccctcctgc ccctcctcct 6900
gctcctgccc ctcctcctgc tcctgcccct cctgcccctc ctgcccctcc tcctgctcct 6960
gcccctcctc ctgctcctgc ccctcctgcc cctcctgccc ctcctgcccc tcctcctgct 7020
cctgcccctc ctcctgctcc tgcccctcct gctcctgccc ctcccgctcc tgctcctgct 7080
cctgttccac cgtgggtccc tttgcagcca atgcaacttg gacgtttttg gggtctccgg 7140
acaccatctc tatgtcttgg ccctgatcct gagccgcccg gggctcctgg tcttccgcct 7200
cctcgtcctc gtcctcttcc ccgtcctcgt ccatggttat caccccctct tctttgaggt 7260
ccactgccgc cggagccttc tggtccagat gtgtctccct tctctcctag gccatttcca 7320
ggtcctgtac ctggcccctc gtcagacatg attcacacta aaagagatca atagacatct 7380
ttattagacg acgctcagtg aatacaggga gtgcagactc ctgccccctc caacagcccc 7440
cccaccctca tccccttcat ggtcgctgtc agacagatcc aggtctgaaa attccccatc 7500
ctccgaacca tcctcgtcct catcaccaat tactcgcagc ccggaaaact cccgctgaac 7560
atcctcaaga tttgcgtcct gagcctcaag ccaggcctca aattcctcgt cccccttttt 7620
gctggacggt agggatgggg attctcggga cccctcctct tcctcttcaa ggtcaccaga 7680
cagagatgct actggggcaa cggaagaaaa gctgggtgcg gcctgtgagg atcagcttat 7740
cgatgataag ctgtcaaaca tgagaattct tgaagacgaa agggcctcgt gatacgccta 7800
tttttatagg ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg 7860
ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg 7920
ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt 7980
attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt 8040
gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg 8100
ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa 8160
cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtgtt 8220
gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag 8280
tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt 8340
gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga 8400
ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt 8460
tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgca 8520
gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg 8580
caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc 8640
cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt 8700
atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg 8760
gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg 8820
attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa 8880
cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa 8940
atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga 9000
tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg 9060
ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact 9120
ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac 9180
cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg 9240
gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg 9300
gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga 9360
acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc 9420
gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg 9480
agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc 9540
tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc 9600
agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttgaagctg tccctgatgg 9660
tcgtcatcta cctgcctgga cagcatggcc tgcaacgcgg gcatcccgat gccgccggaa 9720
gcgagaagaa tcataatggg gaaggccatc cagcctcgcg tcgcgaacgc cagcaagacg 9780
tagcccagcg cgtcggcccc gagatgcgcc gcgtgcggct gctggagatg gcggacgcga 9840
tggatatgtt ctgccaaggg ttggtttgcg cattcacagt tctccgcaag aattgattgg 9900
ctccaattct tggagtggtg aatccgttag cgaggtgccg ccctgcttca tccccgtggc 9960
ccgttgctcg cgtttgctgg cggtgtcccc ggaagaaata tatttgcatg tctttagttc 10020
tatgatgaca caaaccccgc ccagcgtctt gtcattggcg aattcgaaca cgcagatgca 10080
gtcggggcgg cgcggtccga ggtccacttc gcatattaag gtgacgcgtg tggcctcgaa 10140
caccgagcga ccctgcagcg acccgcttaa cagcgtcaac agcgtgccgc agatcccggg 10200
gggcaatgag atatgaaaaa gcctgaactc accgcgacgt ctgtcgagaa gtttctgatc 10260
gaaaagttcg acagcgtctc cgacctgatg cagctctcgg agggcgaaga atctcgtgct 10320
ttcagcttcg atgtaggagg gcgtggatat gtcctgcggg taaatagctg cgccgatggt 10380
ttctacaaag atcgttatgt ttatcggcac tttgcatcgg ccgcgctccc gattccggaa 10440
gtgcttgaca ttggggaatt cagcgagagc ctgacctatt gcatctcccg ccgtgcacag 10500
ggtgtcacgt tgcaagacct gcctgaaacc gaactgcccg ctgttctgca gccggtcgcg 10560
gaggccatgg atgcgatcgc tgcggccgat cttagccaga cgagcgggtt cggcccattc 10620
ggaccgcaag gaatcggtca atacactaca tggcgtgatt tcatatgcgc gattgctgat 10680
ccccatgtgt atcactggca aactgtgatg gacgacaccg tcagtgcgtc cgtcgcgcag 10740
gctctcgatg agctgatgct ttgggccgag gactgccccg aagtccggca cctcgtgcac 10800
gcggatttcg gctccaacaa tgtcctgacg gacaatggcc gcataacagc ggtcattgac 10860
tggagcgagg cgatgttcgg ggattcccaa tacgaggtcg ccaacatctt cttctggagg 10920
ccgtggttgg cttgtatgga gcagcagacg cgctacttcg agcggaggca tccggagctt 10980
gcaggatcgc cgcggctccg ggcgtatatg ctccgcattg gtcttgacca actctatcag 11040
agcttggttg acggcaattt cgatgatgca gcttgggcgc agggtcgatg cgacgcaatc 11100
gtccgatccg gagccgggac tgtcgggcgt acacaaatcg cccgcagaag cgcggccgtc 11160
tggaccgatg gctgtgtaga agtactcgcc gatagtggaa accgacgccc cagcactcgt 11220
ccggatcggg agatggggga ggctaactga aacacggaag gagacaatac cggaaggaac 11280
ccgcgctatg acggcaataa aaagacagaa taaaacgcac gggtgttggg tcgtttgttc 11340
ataaacgcgg ggttcggtcc cagggctggc actctgtcga taccccaccg agaccccatt 11400
ggggccaata cgcccgcgtt tcttcctttt ccccacccca ccccccaagt tcgggtgaag 11460
gcccagggct cgcagccaac gtcggggcgg caggccctgc catagccact ggccccgtgg 11520
gttagggacg gggtccccca tggggaatgg tttatggttc gtgggggtta ttattttggg 11580
cgttgcgtgg ggtcaggtcc acgactggac tgagcagaca gacccatggt ttttggatgg 11640
cctgggcatg gaccgcatgt actggcgcga cacgaacacc gggcgtctgt ggctgccaaa 11700
cacccccgac ccccaaaaac caccgcgcgg atttctggcg tgccaagcta gtcgaccaat 11760
tctcatgttt gacagcttat catcgcagat ccgggcaacg ttgttgccat tgctgcaggc 11820
gcagaactgg taggtatgga agatctatac attgaatcaa tattggcaat tagccatatt 11880
agtcattggt tatatagcat aaatcaatat tggctattgg ccattgcata cgttgtatct 11940
atatcataat atgtacattt atattggctc atgtccaata tgaccgccat            11990



<210> 241
<211> 777
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p3560).

<400> 241
tcctactgcg gcgagcactt ccgctggggc tgcccggtgg gatccggtgg aggctccggt 60
accttagtcg ccgtctcctc agagcccaaa tctgccgaca aaactcacgc ctgcccaccg 120
tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 180
gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 240
gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 300
acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 360
ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc 420
ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 480
tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg 540
gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 600
aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc 660
aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 720
catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa    777

<210> 242
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p3560).

<400> 242
Ser Tyr Cys Gly Glu His Phe Arg Trp Gly Cys Pro Val Gly Ser Gly
 1               5                  10                  15      
Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro Lys Ser Ala
            20                  25                  30          
Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
        35                  40                  45              
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
    50                  55                  60                  
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
65                  70                  75                  80  
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
                85                  90                  95      
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
            100                 105                 110         
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
        115                 120                 125             
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
    130                 135                 140                 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
145                 150                 155                 160 
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
                165                 170                 175     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
            180                 185                 190         
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
        195                 200                 205             
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
    210                 215                 220                 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
225                 230                 235                 240 
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
                245                 250                 255     
Pro Gly Lys
            


<210> 243
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p3560).

<400> 243
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggcctcc 60
tactgcggcg agcacttccg ctggggctgc ccggtgggat ccggtggagg ctccggtacc 120
ttagtcgccg tctcctcaga gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc 180
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 240
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 300
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 360
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 420
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 480
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 540
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 600
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 660
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 720
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 780
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa       834

<210> 244
<211> 278
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p3560).

<400> 244
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Ser Tyr Cys Gly Glu His Phe Arg Trp Gly Cys Pro Val
            20                  25                  30          
Gly Ser Gly Gly Gly Ser Gly Thr Leu Val Ala Val Ser Ser Glu Pro
        35                  40                  45              
Lys Ser Ala Asp Lys Thr His Ala Cys Pro Pro Cys Pro Ala Pro Glu
    50                  55                  60                  
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
65                  70                  75                  80  
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                85                  90                  95      
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            100                 105                 110         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        115                 120                 125             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    130                 135                 140                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
145                 150                 155                 160 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                165                 170                 175     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            180                 185                 190         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        195                 200                 205             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    210                 215                 220                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
225                 230                 235                 240 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                245                 250                 255     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            260                 265                 270         
Ser Leu Ser Pro Gly Lys
        275             


<210> 245
<211> 11969
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p3560).

<400> 245
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggcctcc tactgcggcg agcacttccg 1680
ctggggctgc ccggtgggat ccggtggagg ctccggtacc ttagtcgccg tctcctcaga 1740
gcccaaatct gccgacaaaa ctcacgcctg cccaccgtgc ccagcacctg aactcctggg 1800
gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac 1860
ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa 1920
ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta 1980
caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg 2040
caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat 2100
ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga 2160
tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga 2220
catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc 2280
cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag 2340
gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta 2400
cacgcagaag agcctctccc tgtctccggg taaatgaggg cccgtttaaa cagatccaga 2460
catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg 2520
ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa 2580
acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga 2640
ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg atccggctgc 2700
ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc 2760
acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcaggcgtc agcgggtgtt 2820
ggcgggtgtc ggggcgcagc catgaggtcg actctagagg atcgatgccc cgccccggac 2880
gaactaaacc tgactacgac atctctgccc cttcttcgcg gggcagtgca tgtaatccct 2940
tcagttggtt ggtacaactt gccaactggg ccctgttcca catgtgacac ggggggggac 3000
caaacacaaa ggggttctct gactgtagtt gacatcctta taaatggatg tgcacatttg 3060
ccaacactga gtggctttca tcctggagca gactttgcag tctgtggact gcaacacaac 3120
attgccttta tgtgtaactc ttggctgaag ctcttacacc aatgctgggg gacatgtacc 3180
tcccaggggc ccaggaagac tacgggaggc tacaccaacg tcaatcagag gggcctgtgt 3240
agctaccgat aagcggaccc tcaagagggc attagcaata gtgtttataa ggcccccttg 3300
ttaaccctaa acgggtagca tatgcttccc gggtagtagt atatactatc cagactaacc 3360
ctaattcaat agcatatgtt acccaacggg aagcatatgc tatcgaatta gggttagtaa 3420
aagggtccta aggaacagcg atatctccca ccccatgagc tgtcacggtt ttatttacat 3480
ggggtcagga ttccacgagg gtagtgaacc attttagtca caagggcagt ggctgaagat 3540
caaggagcgg gcagtgaact ctcctgaatc ttcgcctgct tcttcattct ccttcgttta 3600
gctaatagaa taactgctga gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa 3660
ggtttcaggt gacgccccca gaataaaatt tggacggggg gttcagtggt ggcattgtgc 3720
tatgacacca atataaccct cacaaacccc ttgggcaata aatactagtg taggaatgaa 3780
acattctgaa tatctttaac aatagaaatc catggggtgg ggacaagccg taaagactgg 3840
atgtccatct cacacgaatt tatggctatg ggcaacacat aatcctagtg caatatgata 3900
ctggggttat taagatgtgt cccaggcagg gaccaagaca ggtgaaccat gttgttacac 3960
tctatttgta acaaggggaa agagagtgga cgccgacagc agcggactcc actggttgtc 4020
tctaacaccc ccgaaaatta aacggggctc cacgccaatg gggcccataa acaaagacaa 4080
gtggccactc ttttttttga aattgtggag tgggggcacg cgtcagcccc cacacgccgc 4140
cctgcggttt tggactgtaa aataagggtg taataacttg gctgattgta accccgctaa 4200
ccactgcggt caaaccactt gcccacaaaa ccactaatgg caccccgggg aatacctgca 4260
taagtaggtg ggcgggccaa gataggggcg cgattgctgc gatctggagg acaaattaca 4320
cacacttgcg cctgagcgcc aagcacaggg ttgttggtcc tcatattcac gaggtcgctg 4380
agagcacggt gggctaatgt tgccatgggt agcatatact acccaaatat ctggatagca 4440
tatgctatcc taatctatat ctgggtagca taggctatcc taatctatat ctgggtagca 4500
tatgctatcc taatctatat ctgggtagta tatgctatcc taatttatat ctgggtagca 4560
taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta 4620
tatgctatcc taatctgtat ccgggtagca tatgctatcc taatagagat tagggtagta 4680
tatgctatcc taatttatat ctgggtagca tatactaccc aaatatctgg atagcatatg 4740
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagcatagg 4800
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg 4860
ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg 4920
ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg gtagcatatg 4980
ctatcctcat gcatatacag tcagcatatg atacccagta gtagagtggg agtgctatcc 5040
tttgcatatg ccgccacctc ccaagggggc gtgaattttc gctgcttgtc cttttcctgc 5100
tggttgctcc cattcttagg tgaatttaag gaggccaggc taaagccgtc gcatgtctga 5160
ttgctcacca ggtaaatgtc gctaatgttt tccaacgcga gaaggtgttg agcgcggagc 5220
tgagtgacgt gacaacatgg gtatgcccaa ttgccccatg ttgggaggac gaaaatggtg 5280
acaagacaga tggccagaaa tacaccaaca gcacgcatga tgtctactgg ggatttattc 5340
tttagtgcgg gggaatacac ggcttttaat acgattgagg gcgtctccta acaagttaca 5400
tcactcctgc ccttcctcac cctcatctcc atcacctcct tcatctccgt catctccgtc 5460
atcaccctcc gcggcagccc cttccaccat aggtggaaac cagggaggca aatctactcc 5520
atcgtcaaag ctgcacacag tcaccctgat attgcaggta ggagcgggct ttgtcataac 5580
aaggtcctta atcgcatcct tcaaaacctc agcaaatata tgagtttgta aaaagaccat 5640
gaaataacag acaatggact cccttagcgg gccaggttgt gggccgggtc caggggccat 5700
tccaaagggg agacgactca atggtgtaag acgacattgt ggaatagcaa gggcagttcc 5760
tcgccttagg ttgtaaaggg aggtcttact acctccatat acgaacacac cggcgaccca 5820
agttccttcg tcggtagtcc tttctacgtg actcctagcc aggagagctc ttaaaccttc 5880
tgcaatgttc tcaaatttcg ggttggaacc tccttgacca cgatgctttt ccaaaccacc 5940
ctcctttttt gcgccctgcc tccatcaccc tgaccccggg gtccagtgct tgggccttct 6000
cctgggtcat ctgcggggcc ctgctctatc gctcccgggg gcacgtcagg ctcaccatct 6060
gggccacctt cttggtggta ttcaaaataa tcggcttccc ctacagggtg gaaaaatggc 6120
cttctacctg gagggggcct gcgcggtgga gacccggatg atgatgactg actactggga 6180
ctcctgggcc tcttttctcc acgtccacga cctctccccc tggctctttc acgacttccc 6240
cccctggctc tttcacgtcc tctaccccgg cggcctccac tacctcctcg accccggcct 6300
ccactacctc ctcgaccccg gcctccactg cctcctcgac cccggcctcc acctcctgct 6360
cctgcccctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgctcct 6420
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctgctcctgc ccctcctgcc 6480
cctcctcctg ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6540
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6600
cctgctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc ccctcctgcc 6660
cctcctcctg ctcctgcccc tcctgctcct gcccctcctg cccctcctgc ccctcctgct 6720
cctgcccctc ctcctgctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6780
cctcctgccc ctcctcctgc tcctgcccct cctcctgctc ctgcccctcc tgcccctcct 6840
gcccctcctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctcctgct 6900
cctgcccctc ctgcccctcc tgcccctcct cctgctcctg cccctcctcc tgctcctgcc 6960
cctcctgccc ctcctgcccc tcctgcccct cctcctgctc ctgcccctcc tcctgctcct 7020
gcccctcctg ctcctgcccc tcccgctcct gctcctgctc ctgttccacc gtgggtccct 7080
ttgcagccaa tgcaacttgg acgtttttgg ggtctccgga caccatctct atgtcttggc 7140
cctgatcctg agccgcccgg ggctcctggt cttccgcctc ctcgtcctcg tcctcttccc 7200
cgtcctcgtc catggttatc accccctctt ctttgaggtc cactgccgcc ggagccttct 7260
ggtccagatg tgtctccctt ctctcctagg ccatttccag gtcctgtacc tggcccctcg 7320
tcagacatga ttcacactaa aagagatcaa tagacatctt tattagacga cgctcagtga 7380
atacagggag tgcagactcc tgccccctcc aacagccccc ccaccctcat ccccttcatg 7440
gtcgctgtca gacagatcca ggtctgaaaa ttccccatcc tccgaaccat cctcgtcctc 7500
atcaccaatt actcgcagcc cggaaaactc ccgctgaaca tcctcaagat ttgcgtcctg 7560
agcctcaagc caggcctcaa attcctcgtc cccctttttg ctggacggta gggatgggga 7620
ttctcgggac ccctcctctt cctcttcaag gtcaccagac agagatgcta ctggggcaac 7680
ggaagaaaag ctgggtgcgg cctgtgagga tcagcttatc gatgataagc tgtcaaacat 7740
gagaattctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg 7800
ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct 7860
atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 7920
taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc 7980
cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg 8040
aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc 8100
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact 8160
tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc 8220
ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag 8280
catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat 8340
aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt 8400
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa 8460
gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc 8520
aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg 8580
gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt 8640
gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca 8700
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat 8760
gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca 8820
gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg 8880
atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg 8940
ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt 9000
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg 9060
ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata 9120
ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca 9180
ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag 9240
tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc 9300
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga 9360
tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg 9420
tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac 9480
gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg 9540
tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg 9600
ttcctggcct tttgctggcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac 9660
agcatggcct gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg 9720
aaggccatcc agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccccg 9780
agatgcgccg cgtgcggctg ctggagatgg cggacgcgat ggatatgttc tgccaagggt 9840
tggtttgcgc attcacagtt ctccgcaaga attgattggc tccaattctt ggagtggtga 9900
atccgttagc gaggtgccgc cctgcttcat ccccgtggcc cgttgctcgc gtttgctggc 9960
ggtgtccccg gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc 10020
cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag 10080
gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga 10140
cccgcttaac agcgtcaaca gcgtgccgca gatcccgggg ggcaatgaga tatgaaaaag 10200
cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc 10260
gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg 10320
cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga tcgttatgtt 10380
tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat tggggaattc 10440
agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg 10500
cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct 10560
gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa 10620
tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta tcactggcaa 10680
actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt 10740
tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg ctccaacaat 10800
gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc gatgttcggg 10860
gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc ttgtatggag 10920
cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc gcggctccgg 10980
gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga cggcaatttc 11040
gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg agccgggact 11100
gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa 11160
gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cggatcggga gatgggggag 11220
gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga cggcaataaa 11280
aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg gttcggtccc 11340
agggctggca ctctgtcgat accccaccga gaccccattg gggccaatac gcccgcgttt 11400
cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc gcagccaacg 11460
tcggggcggc aggccctgcc atagccactg gccccgtggg ttagggacgg ggtcccccat 11520
ggggaatggt ttatggttcg tgggggttat tattttgggc gttgcgtggg gtcaggtcca 11580
cgactggact gagcagacag acccatggtt tttggatggc ctgggcatgg accgcatgta 11640
ctggcgcgac acgaacaccg ggcgtctgtg gctgccaaac acccccgacc cccaaaaacc 11700
accgcgcgga tttctggcgt gccaagctag tcgaccaatt ctcatgtttg acagcttatc 11760
atcgcagatc cgggcaacgt tgttgccatt gctgcaggcg cagaactggt aggtatggaa 11820
gatctataca ttgaatcaat attggcaatt agccatatta gtcattggtt atatagcata 11880
aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta 11940
tattggctca tgtccaatat gaccgccat                                   11969



<210> 246
<211> 330
<212> DNA
<213> Homo sapiens

<220> 
<223> gcacctgaagccgccgggggaccgtcagtcttcctcttccccccaaaacc
      caaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtgg
      tggacgt

<400> 246
gcacctgaag ccgccggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc 60
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac 120
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag 180
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac 240
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc 300
cccatcgaga aaaccatctc caaagccaaa                                  330

<210> 247
<211> 110
<212> PRT
<213> Homo sapiens

<400> 247
Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 248
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro mutagenized Homo sapien DNA encoding a V2
      peptide sequence comprising a T to A substitution to
      limit O-linked glycosylation.

<400> 248
accttagtca ccgtctcctc a                                           21

<210> 249
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutagenized Homo sapien V2 peptide comprising a
      T to A substitution to limit O-linked glycosylation
      and encoded by an in vitro mutagenized Homo sapien
      DNA.

<400> 249
Thr Leu Val Thr Val Ser Ser
 1               5          


<210> 250
<211> 732
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p4362).

<400> 250
ggcggatgcg agcacttccg ctggtgcaag ccggtgggag gcggaggaag cggcggaggc 60
ggatcctgcc caccatgccc ggcgcctgag gccgccgggg gaccatcagt cttcctgttc 120
cccccaaaac ccaaggacac tctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg 180
gtggacgtga gccaggaaga ccccgaggtc cagttcaact ggtacgtgga tggcgtggag 240
gtgcataatg ccaagacaaa gccgcgggag gagcagttca acagcacgta ccgtgtggtc 300
agcgtcctca ccgtcctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc 360
tccaacaaag gcctcccgtc ctccatcgag aaaaccatct ccaaagccaa agggcagcct 420
cgagagccac aggtgtacac cctgccccca tcccaggagg agatgaccaa gaaccaggtc 480
agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc 540
aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 600
ttcttcctct acagcaggct aaccgtggac aagagcaggt ggcaggaggg gaatgtcttc 660
tcatgctccg tgatgcatga ggctctgcac aaccactaca cacagaaaag cttgtccctg 720
tctctgggta aa                                                     732

<210> 251
<211> 244
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p4362).

<400> 251
Gly Gly Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly Gly Gly Gly
 1               5                  10                  15      
Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala
            20                  25                  30          
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
        35                  40                  45              
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
    50                  55                  60                  
Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu
65                  70                  75                  80  
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr
                85                  90                  95      
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
            100                 105                 110         
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser
        115                 120                 125             
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
    130                 135                 140                 
Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val
145                 150                 155                 160 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
                165                 170                 175     
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
            180                 185                 190         
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr
        195                 200                 205             
Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val
    210                 215                 220                 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
225                 230                 235                 240 
Ser Leu Gly Lys
                


<210> 252
<211> 789
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p4362).

<400> 252
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggccggc 60
ggatgcgagc acttccgctg gtgcaagccg gtgggaggcg gaggaagcgg cggaggcgga 120
tcctgcccac catgcccggc gcctgaggcc gccgggggac catcagtctt cctgttcccc 180
ccaaaaccca aggacactct catgatctcc cggacccctg aggtcacgtg cgtggtggtg 240
gacgtgagcc aggaagaccc cgaggtccag ttcaactggt acgtggatgg cgtggaggtg 300
cataatgcca agacaaagcc gcgggaggag cagttcaaca gcacgtaccg tgtggtcagc 360
gtcctcaccg tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc 420
aacaaaggcc tcccgtcctc catcgagaaa accatctcca aagccaaagg gcagcctcga 480
gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa ccaggtcagc 540
ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat 600
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc 660
ttcctctaca gcaggctaac cgtggacaag agcaggtggc aggaggggaa tgtcttctca 720
tgctccgtga tgcatgaggc tctgcacaac cactacacac agaaaagctt gtccctgtct 780
ctgggtaaa                                                         789

<210> 253
<211> 263
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p4362).

<400> 253
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Gly Gly Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly
            20                  25                  30          
Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro
        35                  40                  45              
Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
    50                  55                  60                  
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
65                  70                  75                  80  
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
                85                  90                  95      
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
            100                 105                 110         
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
        115                 120                 125             
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
    130                 135                 140                 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
145                 150                 155                 160 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
                165                 170                 175     
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
            180                 185                 190         
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
        195                 200                 205             
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
    210                 215                 220                 
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
225                 230                 235                 240 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
                245                 250                 255     
Leu Ser Leu Ser Leu Gly Lys
            260             


<210> 254
<211> 11924
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p4362).

<400> 254
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggccggc ggatgcgagc acttccgctg 1680
gtgcaagccg gtgggaggcg gaggaagcgg cggaggcgga tcctgcccac catgcccggc 1740
gcctgaggcc gccgggggac catcagtctt cctgttcccc ccaaaaccca aggacactct 1800
catgatctcc cggacccctg aggtcacgtg cgtggtggtg gacgtgagcc aggaagaccc 1860
cgaggtccag ttcaactggt acgtggatgg cgtggaggtg cataatgcca agacaaagcc 1920
gcgggaggag cagttcaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca 1980
ggactggctg aacggcaagg agtacaagtg caaggtctcc aacaaaggcc tcccgtcctc 2040
catcgagaaa accatctcca aagccaaagg gcagcctcga gagccacagg tgtacaccct 2100
gcccccatcc caggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg 2160
cttctacccc agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta 2220
caagaccacg cctcccgtgc tggactccga cggctccttc ttcctctaca gcaggctaac 2280
cgtggacaag agcaggtggc aggaggggaa tgtcttctca tgctccgtga tgcatgaggc 2340
tctgcacaac cactacacac agaaaagctt gtccctgtct ctgggtaaat gagggcccgt 2400
ttaaacagat ccagacatga taagatacat tgatgagttt ggacaaacca caactagaat 2460
gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat 2520
tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca 2580
gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtatggctga 2640
ttatgatccg gctgcctcgc gcgtttcggt gatgacggtg aaaacctctg acacatgcag 2700
ctcccggaga cggtcacagc ttgtctgtaa gcggatgccg ggagcagaca agcccgtcag 2760
gcgtcagcgg gtgttggcgg gtgtcggggc gcagccatga ggtcgactct agaggatcga 2820
tgccccgccc cggacgaact aaacctgact acgacatctc tgccccttct tcgcggggca 2880
gtgcatgtaa tcccttcagt tggttggtac aacttgccaa ctgggccctg ttccacatgt 2940
gacacggggg gggaccaaac acaaaggggt tctctgactg tagttgacat ccttataaat 3000
ggatgtgcac atttgccaac actgagtggc tttcatcctg gagcagactt tgcagtctgt 3060
ggactgcaac acaacattgc ctttatgtgt aactcttggc tgaagctctt acaccaatgc 3120
tgggggacat gtacctccca ggggcccagg aagactacgg gaggctacac caacgtcaat 3180
cagaggggcc tgtgtagcta ccgataagcg gaccctcaag agggcattag caatagtgtt 3240
tataaggccc ccttgttaac cctaaacggg tagcatatgc ttcccgggta gtagtatata 3300
ctatccagac taaccctaat tcaatagcat atgttaccca acgggaagca tatgctatcg 3360
aattagggtt agtaaaaggg tcctaaggaa cagcgatatc tcccacccca tgagctgtca 3420
cggttttatt tacatggggt caggattcca cgagggtagt gaaccatttt agtcacaagg 3480
gcagtggctg aagatcaagg agcgggcagt gaactctcct gaatcttcgc ctgcttcttc 3540
attctccttc gtttagctaa tagaataact gctgagttgt gaacagtaag gtgtatgtga 3600
ggtgctcgaa aacaaggttt caggtgacgc ccccagaata aaatttggac ggggggttca 3660
gtggtggcat tgtgctatga caccaatata accctcacaa accccttggg caataaatac 3720
tagtgtagga atgaaacatt ctgaatatct ttaacaatag aaatccatgg ggtggggaca 3780
agccgtaaag actggatgtc catctcacac gaatttatgg ctatgggcaa cacataatcc 3840
tagtgcaata tgatactggg gttattaaga tgtgtcccag gcagggacca agacaggtga 3900
accatgttgt tacactctat ttgtaacaag gggaaagaga gtggacgccg acagcagcgg 3960
actccactgg ttgtctctaa cacccccgaa aattaaacgg ggctccacgc caatggggcc 4020
cataaacaaa gacaagtggc cactcttttt tttgaaattg tggagtgggg gcacgcgtca 4080
gcccccacac gccgccctgc ggttttggac tgtaaaataa gggtgtaata acttggctga 4140
ttgtaacccc gctaaccact gcggtcaaac cacttgccca caaaaccact aatggcaccc 4200
cggggaatac ctgcataagt aggtgggcgg gccaagatag gggcgcgatt gctgcgatct 4260
ggaggacaaa ttacacacac ttgcgcctga gcgccaagca cagggttgtt ggtcctcata 4320
ttcacgaggt cgctgagagc acggtgggct aatgttgcca tgggtagcat atactaccca 4380
aatatctgga tagcatatgc tatcctaatc tatatctggg tagcataggc tatcctaatc 4440
tatatctggg tagcatatgc tatcctaatc tatatctggg tagtatatgc tatcctaatt 4500
tatatctggg tagcataggc tatcctaatc tatatctggg tagcatatgc tatcctaatc 4560
tatatctggg tagtatatgc tatcctaatc tgtatccggg tagcatatgc tatcctaata 4620
gagattaggg tagtatatgc tatcctaatt tatatctggg tagcatatac tacccaaata 4680
tctggatagc atatgctatc ctaatctata tctgggtagc atatgctatc ctaatctata 4740
tctgggtagc ataggctatc ctaatctata tctgggtagc atatgctatc ctaatctata 4800
tctgggtagt atatgctatc ctaatttata tctgggtagc ataggctatc ctaatctata 4860
tctgggtagc atatgctatc ctaatctata tctgggtagt atatgctatc ctaatctgta 4920
tccgggtagc atatgctatc ctcatgcata tacagtcagc atatgatacc cagtagtaga 4980
gtgggagtgc tatcctttgc atatgccgcc acctcccaag ggggcgtgaa ttttcgctgc 5040
ttgtcctttt cctgctggtt gctcccattc ttaggtgaat ttaaggaggc caggctaaag 5100
ccgtcgcatg tctgattgct caccaggtaa atgtcgctaa tgttttccaa cgcgagaagg 5160
tgttgagcgc ggagctgagt gacgtgacaa catgggtatg cccaattgcc ccatgttggg 5220
aggacgaaaa tggtgacaag acagatggcc agaaatacac caacagcacg catgatgtct 5280
actggggatt tattctttag tgcgggggaa tacacggctt ttaatacgat tgagggcgtc 5340
tcctaacaag ttacatcact cctgcccttc ctcaccctca tctccatcac ctccttcatc 5400
tccgtcatct ccgtcatcac cctccgcggc agccccttcc accataggtg gaaaccaggg 5460
aggcaaatct actccatcgt caaagctgca cacagtcacc ctgatattgc aggtaggagc 5520
gggctttgtc ataacaaggt ccttaatcgc atccttcaaa acctcagcaa atatatgagt 5580
ttgtaaaaag accatgaaat aacagacaat ggactccctt agcgggccag gttgtgggcc 5640
gggtccaggg gccattccaa aggggagacg actcaatggt gtaagacgac attgtggaat 5700
agcaagggca gttcctcgcc ttaggttgta aagggaggtc ttactacctc catatacgaa 5760
cacaccggcg acccaagttc cttcgtcggt agtcctttct acgtgactcc tagccaggag 5820
agctcttaaa ccttctgcaa tgttctcaaa tttcgggttg gaacctcctt gaccacgatg 5880
cttttccaaa ccaccctcct tttttgcgcc ctgcctccat caccctgacc ccggggtcca 5940
gtgcttgggc cttctcctgg gtcatctgcg gggccctgct ctatcgctcc cgggggcacg 6000
tcaggctcac catctgggcc accttcttgg tggtattcaa aataatcggc ttcccctaca 6060
gggtggaaaa atggccttct acctggaggg ggcctgcgcg gtggagaccc ggatgatgat 6120
gactgactac tgggactcct gggcctcttt tctccacgtc cacgacctct ccccctggct 6180
ctttcacgac ttccccccct ggctctttca cgtcctctac cccggcggcc tccactacct 6240
cctcgacccc ggcctccact acctcctcga ccccggcctc cactgcctcc tcgaccccgg 6300
cctccacctc ctgctcctgc ccctcctgct cctgcccctc ctcctgctcc tgcccctcct 6360
gcccctcctg ctcctgcccc tcctgcccct cctgctcctg cccctcctgc ccctcctgct 6420
cctgcccctc ctgcccctcc tcctgctcct gcccctcctg cccctcctcc tgctcctgcc 6480
cctcctgccc ctcctgctcc tgcccctcct gcccctcctg ctcctgcccc tcctgcccct 6540
cctgctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc tcctgcccct 6600
cctgcccctc ctgcccctcc tcctgctcct gcccctcctg ctcctgcccc tcctgcccct 6660
cctgcccctc ctgctcctgc ccctcctcct gctcctgccc ctcctgcccc tcctgcccct 6720
cctcctgctc ctgcccctcc tgcccctcct cctgctcctg cccctcctcc tgctcctgcc 6780
cctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctgcccctcc tcctgctcct 6840
gcccctcctc ctgctcctgc ccctcctgcc cctcctgccc ctcctcctgc tcctgcccct 6900
cctcctgctc ctgcccctcc tgcccctcct gcccctcctg cccctcctcc tgctcctgcc 6960
cctcctcctg ctcctgcccc tcctgctcct gcccctcccg ctcctgctcc tgctcctgtt 7020
ccaccgtggg tccctttgca gccaatgcaa cttggacgtt tttggggtct ccggacacca 7080
tctctatgtc ttggccctga tcctgagccg cccggggctc ctggtcttcc gcctcctcgt 7140
cctcgtcctc ttccccgtcc tcgtccatgg ttatcacccc ctcttctttg aggtccactg 7200
ccgccggagc cttctggtcc agatgtgtct cccttctctc ctaggccatt tccaggtcct 7260
gtacctggcc cctcgtcaga catgattcac actaaaagag atcaatagac atctttatta 7320
gacgacgctc agtgaataca gggagtgcag actcctgccc cctccaacag cccccccacc 7380
ctcatcccct tcatggtcgc tgtcagacag atccaggtct gaaaattccc catcctccga 7440
accatcctcg tcctcatcac caattactcg cagcccggaa aactcccgct gaacatcctc 7500
aagatttgcg tcctgagcct caagccaggc ctcaaattcc tcgtccccct ttttgctgga 7560
cggtagggat ggggattctc gggacccctc ctcttcctct tcaaggtcac cagacagaga 7620
tgctactggg gcaacggaag aaaagctggg tgcggcctgt gaggatcagc ttatcgatga 7680
taagctgtca aacatgagaa ttcttgaaga cgaaagggcc tcgtgatacg cctattttta 7740
taggttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat 7800
gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg 7860
agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa 7920
catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac 7980
ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac 8040
atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt 8100
ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tgttgacgcc 8160
gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca 8220
ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc 8280
ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag 8340
gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa 8400
ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgcagcaatg 8460
gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa 8520
ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg 8580
gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt 8640
gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt 8700
caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag 8760
cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat 8820
ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct 8880
taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct 8940
tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca 9000
gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc 9060
agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc 9120
aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct 9180
gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag 9240
gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc 9300
tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg 9360
agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag 9420
cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt 9480
gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac 9540
gcggcctttt tacggttcct ggccttttgc tggccttgaa gctgtccctg atggtcgtca 9600
tctacctgcc tggacagcat ggcctgcaac gcgggcatcc cgatgccgcc ggaagcgaga 9660
agaatcataa tggggaaggc catccagcct cgcgtcgcga acgccagcaa gacgtagccc 9720
agcgcgtcgg ccccgagatg cgccgcgtgc ggctgctgga gatggcggac gcgatggata 9780
tgttctgcca agggttggtt tgcgcattca cagttctccg caagaattga ttggctccaa 9840
ttcttggagt ggtgaatccg ttagcgaggt gccgccctgc ttcatccccg tggcccgttg 9900
ctcgcgtttg ctggcggtgt ccccggaaga aatatatttg catgtcttta gttctatgat 9960
gacacaaacc ccgcccagcg tcttgtcatt ggcgaattcg aacacgcaga tgcagtcggg 10020
gcggcgcggt ccgaggtcca cttcgcatat taaggtgacg cgtgtggcct cgaacaccga 10080
gcgaccctgc agcgacccgc ttaacagcgt caacagcgtg ccgcagatcc cggggggcaa 10140
tgagatatga aaaagcctga actcaccgcg acgtctgtcg agaagtttct gatcgaaaag 10200
ttcgacagcg tctccgacct gatgcagctc tcggagggcg aagaatctcg tgctttcagc 10260
ttcgatgtag gagggcgtgg atatgtcctg cgggtaaata gctgcgccga tggtttctac 10320
aaagatcgtt atgtttatcg gcactttgca tcggccgcgc tcccgattcc ggaagtgctt 10380
gacattgggg aattcagcga gagcctgacc tattgcatct cccgccgtgc acagggtgtc 10440
acgttgcaag acctgcctga aaccgaactg cccgctgttc tgcagccggt cgcggaggcc 10500
atggatgcga tcgctgcggc cgatcttagc cagacgagcg ggttcggccc attcggaccg 10560
caaggaatcg gtcaatacac tacatggcgt gatttcatat gcgcgattgc tgatccccat 10620
gtgtatcact ggcaaactgt gatggacgac accgtcagtg cgtccgtcgc gcaggctctc 10680
gatgagctga tgctttgggc cgaggactgc cccgaagtcc ggcacctcgt gcacgcggat 10740
ttcggctcca acaatgtcct gacggacaat ggccgcataa cagcggtcat tgactggagc 10800
gaggcgatgt tcggggattc ccaatacgag gtcgccaaca tcttcttctg gaggccgtgg 10860
ttggcttgta tggagcagca gacgcgctac ttcgagcgga ggcatccgga gcttgcagga 10920
tcgccgcggc tccgggcgta tatgctccgc attggtcttg accaactcta tcagagcttg 10980
gttgacggca atttcgatga tgcagcttgg gcgcagggtc gatgcgacgc aatcgtccga 11040
tccggagccg ggactgtcgg gcgtacacaa atcgcccgca gaagcgcggc cgtctggacc 11100
gatggctgtg tagaagtact cgccgatagt ggaaaccgac gccccagcac tcgtccggat 11160
cgggagatgg gggaggctaa ctgaaacacg gaaggagaca ataccggaag gaacccgcgc 11220
tatgacggca ataaaaagac agaataaaac gcacgggtgt tgggtcgttt gttcataaac 11280
gcggggttcg gtcccagggc tggcactctg tcgatacccc accgagaccc cattggggcc 11340
aatacgcccg cgtttcttcc ttttccccac cccacccccc aagttcgggt gaaggcccag 11400
ggctcgcagc caacgtcggg gcggcaggcc ctgccatagc cactggcccc gtgggttagg 11460
gacggggtcc cccatgggga atggtttatg gttcgtgggg gttattattt tgggcgttgc 11520
gtggggtcag gtccacgact ggactgagca gacagaccca tggtttttgg atggcctggg 11580
catggaccgc atgtactggc gcgacacgaa caccgggcgt ctgtggctgc caaacacccc 11640
cgacccccaa aaaccaccgc gcggatttct ggcgtgccaa gctagtcgac caattctcat 11700
gtttgacagc ttatcatcgc agatccgggc aacgttgttg ccattgctgc aggcgcagaa 11760
ctggtaggta tggaagatct atacattgaa tcaatattgg caattagcca tattagtcat 11820
tggttatata gcataaatca atattggcta ttggccattg catacgttgt atctatatca 11880
taatatgtac atttatattg gctcatgtcc aatatgaccg ccat                  11924



<210> 255
<211> 753
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p4371).

<400> 255
ggcggatgcg agcacttccg ctggtgcaag ccggtgggat ccggtacctt agtcaccaac 60
tccaccgagt ccaaatatgg tcccccatgc ccaccatgcc cggcgcctga ggccgccggg 120
ggaccatcag tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc 180
cctgaggtca cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac 240
tggtacgtgg atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc 300
aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc 360
aaggagtaca agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc 420
tccaaagcca aagggcagcc tcgagagcca caggtgtaca ccctgccccc atcccaggag 480
gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac 540
atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc 600
gtgctggact ccgacggctc cttcttcctc tacagcaggc taaccgtgga caagagcagg 660
tggcaggagg ggaatgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac 720
acacagaaaa gcttgtccct gtctctgggt aaa                              753

<210> 256
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p4371).

<400> 256
Gly Gly Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly Ser Gly Thr
 1               5                  10                  15      
Leu Val Thr Asn Ser Thr Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro
            20                  25                  30          
Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro
        35                  40                  45              
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
    50                  55                  60                  
Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
65                  70                  75                  80  
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                85                  90                  95      
Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
            100                 105                 110         
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
        115                 120                 125             

Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
    130                 135                 140                 
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
145                 150                 155                 160 
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                165                 170                 175     
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
            180                 185                 190         
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
        195                 200                 205             
Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
    210                 215                 220                 
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
225                 230                 235                 240 
Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
                245                 250     


<210> 257
<211> 810
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p4371).

<400> 257
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggccggc 60
ggatgcgagc acttccgctg gtgcaagccg gtgggatccg gtaccttagt caccaactcc 120
accgagtcca aatatggtcc cccatgccca ccatgcccgg cgcctgaggc cgccggggga 180
ccatcagtct tcctgttccc cccaaaaccc aaggacactc tcatgatctc ccggacccct 240
gaggtcacgt gcgtggtggt ggacgtgagc caggaagacc ccgaggtcca gttcaactgg 300
tacgtggatg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagttcaac 360
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaacggcaag 420
gagtacaagt gcaaggtctc caacaaaggc ctcccgtcct ccatcgagaa aaccatctcc 480
aaagccaaag ggcagcctcg agagccacag gtgtacaccc tgcccccatc ccaggaggag 540
atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc 600
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 660
ctggactccg acggctcctt cttcctctac agcaggctaa ccgtggacaa gagcaggtgg 720
caggagggga atgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca 780
cagaaaagct tgtccctgtc tctgggtaaa                                  810

<210> 258
<211> 270
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p4371).

<400> 258
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Gly Gly Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly
            20                  25                  30          
Ser Gly Thr Leu Val Thr Asn Ser Thr Glu Ser Lys Tyr Gly Pro Pro
        35                  40                  45              
Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe
    50                  55                  60                  
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
65                  70                  75                  80  
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val
                85                  90                  95      
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
            100                 105                 110         
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val
        115                 120                 125             
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
    130                 135                 140                 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser
145                 150                 155                 160 
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
                165                 170                 175     
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
            180                 185                 190         
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
        195                 200                 205             
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
    210                 215                 220                 
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp
225                 230                 235                 240 
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
                245                 250                 255     
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
            260                 265                 270 


<210> 259
<211> 11945
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p4371).

<400> 259
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggccggc ggatgcgagc acttccgctg 1680
gtgcaagccg gtgggatccg gtaccttagt caccaactcc accgagtcca aatatggtcc 1740
cccatgccca ccatgcccgg cgcctgaggc cgccggggga ccatcagtct tcctgttccc 1800
cccaaaaccc aaggacactc tcatgatctc ccggacccct gaggtcacgt gcgtggtggt 1860
ggacgtgagc caggaagacc ccgaggtcca gttcaactgg tacgtggatg gcgtggaggt 1920
gcataatgcc aagacaaagc cgcgggagga gcagttcaac agcacgtacc gtgtggtcag 1980
cgtcctcacc gtcctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtctc 2040
caacaaaggc ctcccgtcct ccatcgagaa aaccatctcc aaagccaaag ggcagcctcg 2100
agagccacag gtgtacaccc tgcccccatc ccaggaggag atgaccaaga accaggtcag 2160
cctgacctgc ctggtcaaag gcttctaccc cagcgacatc gccgtggagt gggagagcaa 2220
tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt 2280
cttcctctac agcaggctaa ccgtggacaa gagcaggtgg caggagggga atgtcttctc 2340
atgctccgtg atgcatgagg ctctgcacaa ccactacaca cagaaaagct tgtccctgtc 2400
tctgggtaaa tgagggcccg tttaaacaga tccagacatg ataagataca ttgatgagtt 2460
tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc 2520
tattgcttta tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat 2580
tcattttatg tttcaggttc agggggaggt gtgggaggtt ttttaaagca agtaaaacct 2640
ctacaaatgt ggtatggctg attatgatcc ggctgcctcg cgcgtttcgg tgatgacggt 2700
gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc 2760
gggagcagac aagcccgtca ggcgtcagcg ggtgttggcg ggtgtcgggg cgcagccatg 2820
aggtcgactc tagaggatcg atgccccgcc ccggacgaac taaacctgac tacgacatct 2880
ctgccccttc ttcgcggggc agtgcatgta atcccttcag ttggttggta caacttgcca 2940
actgggccct gttccacatg tgacacgggg ggggaccaaa cacaaagggg ttctctgact 3000
gtagttgaca tccttataaa tggatgtgca catttgccaa cactgagtgg ctttcatcct 3060
ggagcagact ttgcagtctg tggactgcaa cacaacattg cctttatgtg taactcttgg 3120
ctgaagctct tacaccaatg ctgggggaca tgtacctccc aggggcccag gaagactacg 3180
ggaggctaca ccaacgtcaa tcagaggggc ctgtgtagct accgataagc ggaccctcaa 3240
gagggcatta gcaatagtgt ttataaggcc cccttgttaa ccctaaacgg gtagcatatg 3300
cttcccgggt agtagtatat actatccaga ctaaccctaa ttcaatagca tatgttaccc 3360
aacgggaagc atatgctatc gaattagggt tagtaaaagg gtcctaagga acagcgatat 3420
ctcccacccc atgagctgtc acggttttat ttacatgggg tcaggattcc acgagggtag 3480
tgaaccattt tagtcacaag ggcagtggct gaagatcaag gagcgggcag tgaactctcc 3540
tgaatcttcg cctgcttctt cattctcctt cgtttagcta atagaataac tgctgagttg 3600
tgaacagtaa ggtgtatgtg aggtgctcga aaacaaggtt tcaggtgacg cccccagaat 3660
aaaatttgga cggggggttc agtggtggca ttgtgctatg acaccaatat aaccctcaca 3720
aaccccttgg gcaataaata ctagtgtagg aatgaaacat tctgaatatc tttaacaata 3780
gaaatccatg gggtggggac aagccgtaaa gactggatgt ccatctcaca cgaatttatg 3840
gctatgggca acacataatc ctagtgcaat atgatactgg ggttattaag atgtgtccca 3900
ggcagggacc aagacaggtg aaccatgttg ttacactcta tttgtaacaa ggggaaagag 3960
agtggacgcc gacagcagcg gactccactg gttgtctcta acacccccga aaattaaacg 4020
gggctccacg ccaatggggc ccataaacaa agacaagtgg ccactctttt ttttgaaatt 4080
gtggagtggg ggcacgcgtc agcccccaca cgccgccctg cggttttgga ctgtaaaata 4140
agggtgtaat aacttggctg attgtaaccc cgctaaccac tgcggtcaaa ccacttgccc 4200
acaaaaccac taatggcacc ccggggaata cctgcataag taggtgggcg ggccaagata 4260
ggggcgcgat tgctgcgatc tggaggacaa attacacaca cttgcgcctg agcgccaagc 4320
acagggttgt tggtcctcat attcacgagg tcgctgagag cacggtgggc taatgttgcc 4380
atgggtagca tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg 4440
gtagcatagg ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg 4500
gtagtatatg ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg 4560
gtagcatatg ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg 4620
gtagcatatg ctatcctaat agagattagg gtagtatatg ctatcctaat ttatatctgg 4680
gtagcatata ctacccaaat atctggatag catatgctat cctaatctat atctgggtag 4740
catatgctat cctaatctat atctgggtag cataggctat cctaatctat atctgggtag 4800
catatgctat cctaatctat atctgggtag tatatgctat cctaatttat atctgggtag 4860
cataggctat cctaatctat atctgggtag catatgctat cctaatctat atctgggtag 4920
tatatgctat cctaatctgt atccgggtag catatgctat cctcatgcat atacagtcag 4980
catatgatac ccagtagtag agtgggagtg ctatcctttg catatgccgc cacctcccaa 5040
gggggcgtga attttcgctg cttgtccttt tcctgctggt tgctcccatt cttaggtgaa 5100
tttaaggagg ccaggctaaa gccgtcgcat gtctgattgc tcaccaggta aatgtcgcta 5160
atgttttcca acgcgagaag gtgttgagcg cggagctgag tgacgtgaca acatgggtat 5220
gcccaattgc cccatgttgg gaggacgaaa atggtgacaa gacagatggc cagaaataca 5280
ccaacagcac gcatgatgtc tactggggat ttattcttta gtgcggggga atacacggct 5340
tttaatacga ttgagggcgt ctcctaacaa gttacatcac tcctgccctt cctcaccctc 5400
atctccatca cctccttcat ctccgtcatc tccgtcatca ccctccgcgg cagccccttc 5460
caccataggt ggaaaccagg gaggcaaatc tactccatcg tcaaagctgc acacagtcac 5520
cctgatattg caggtaggag cgggctttgt cataacaagg tccttaatcg catccttcaa 5580
aacctcagca aatatatgag tttgtaaaaa gaccatgaaa taacagacaa tggactccct 5640
tagcgggcca ggttgtgggc cgggtccagg ggccattcca aaggggagac gactcaatgg 5700
tgtaagacga cattgtggaa tagcaagggc agttcctcgc cttaggttgt aaagggaggt 5760
cttactacct ccatatacga acacaccggc gacccaagtt ccttcgtcgg tagtcctttc 5820
tacgtgactc ctagccagga gagctcttaa accttctgca atgttctcaa atttcgggtt 5880
ggaacctcct tgaccacgat gcttttccaa accaccctcc ttttttgcgc cctgcctcca 5940
tcaccctgac cccggggtcc agtgcttggg ccttctcctg ggtcatctgc ggggccctgc 6000
tctatcgctc ccgggggcac gtcaggctca ccatctgggc caccttcttg gtggtattca 6060
aaataatcgg cttcccctac agggtggaaa aatggccttc tacctggagg gggcctgcgc 6120
ggtggagacc cggatgatga tgactgacta ctgggactcc tgggcctctt ttctccacgt 6180
ccacgacctc tccccctggc tctttcacga cttccccccc tggctctttc acgtcctcta 6240
ccccggcggc ctccactacc tcctcgaccc cggcctccac tacctcctcg accccggcct 6300
ccactgcctc ctcgaccccg gcctccacct cctgctcctg cccctcctgc tcctgcccct 6360
cctcctgctc ctgcccctcc tgcccctcct gctcctgccc ctcctgcccc tcctgctcct 6420
gcccctcctg cccctcctgc tcctgcccct cctgcccctc ctcctgctcc tgcccctcct 6480
gcccctcctc ctgctcctgc ccctcctgcc cctcctgctc ctgcccctcc tgcccctcct 6540
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg ctcctgcccc tcctgctcct 6600
gcccctcctg ctcctgcccc tcctgcccct cctgcccctc ctcctgctcc tgcccctcct 6660
gctcctgccc ctcctgcccc tcctgcccct cctgctcctg cccctcctcc tgctcctgcc 6720
cctcctgccc ctcctgcccc tcctcctgct cctgcccctc ctgcccctcc tcctgctcct 6780
gcccctcctc ctgctcctgc ccctcctgcc cctcctgccc ctcctcctgc tcctgcccct 6840
cctgcccctc ctcctgctcc tgcccctcct cctgctcctg cccctcctgc ccctcctgcc 6900
cctcctcctg ctcctgcccc tcctcctgct cctgcccctc ctgcccctcc tgcccctcct 6960
gcccctcctc ctgctcctgc ccctcctcct gctcctgccc ctcctgctcc tgcccctccc 7020
gctcctgctc ctgctcctgt tccaccgtgg gtccctttgc agccaatgca acttggacgt 7080
ttttggggtc tccggacacc atctctatgt cttggccctg atcctgagcc gcccggggct 7140
cctggtcttc cgcctcctcg tcctcgtcct cttccccgtc ctcgtccatg gttatcaccc 7200
cctcttcttt gaggtccact gccgccggag ccttctggtc cagatgtgtc tcccttctct 7260
cctaggccat ttccaggtcc tgtacctggc ccctcgtcag acatgattca cactaaaaga 7320
gatcaataga catctttatt agacgacgct cagtgaatac agggagtgca gactcctgcc 7380
ccctccaaca gcccccccac cctcatcccc ttcatggtcg ctgtcagaca gatccaggtc 7440
tgaaaattcc ccatcctccg aaccatcctc gtcctcatca ccaattactc gcagcccgga 7500
aaactcccgc tgaacatcct caagatttgc gtcctgagcc tcaagccagg cctcaaattc 7560
ctcgtccccc tttttgctgg acggtaggga tggggattct cgggacccct cctcttcctc 7620
ttcaaggtca ccagacagag atgctactgg ggcaacggaa gaaaagctgg gtgcggcctg 7680
tgaggatcag cttatcgatg ataagctgtc aaacatgaga attcttgaag acgaaagggc 7740
ctcgtgatac gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca 7800
ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat 7860
tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa 7920
aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt 7980
tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag 8040
ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt 8100
tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg 8160
gtattatccc gtgttgacgc cgggcaagag caactcggtc gccgcataca ctattctcag 8220
aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta 8280
agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg 8340
acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta 8400
actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac 8460
accacgatgc ctgcagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt 8520
actctagctt cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca 8580
cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag 8640
cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta 8700
gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag 8760
ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt 8820
tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat 8880
aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta 8940
gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa 9000
acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt 9060
tttccgaagg taactggctt cagcagagcg cagataccaa atactgtcct tctagtgtag 9120
ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta 9180
atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca 9240
agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag 9300
cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa 9360
agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga 9420
acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc 9480
gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc 9540
ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggccttga 9600
agctgtccct gatggtcgtc atctacctgc ctggacagca tggcctgcaa cgcgggcatc 9660
ccgatgccgc cggaagcgag aagaatcata atggggaagg ccatccagcc tcgcgtcgcg 9720
aacgccagca agacgtagcc cagcgcgtcg gccccgagat gcgccgcgtg cggctgctgg 9780
agatggcgga cgcgatggat atgttctgcc aagggttggt ttgcgcattc acagttctcc 9840
gcaagaattg attggctcca attcttggag tggtgaatcc gttagcgagg tgccgccctg 9900
cttcatcccc gtggcccgtt gctcgcgttt gctggcggtg tccccggaag aaatatattt 9960
gcatgtcttt agttctatga tgacacaaac cccgcccagc gtcttgtcat tggcgaattc 10020
gaacacgcag atgcagtcgg ggcggcgcgg tccgaggtcc acttcgcata ttaaggtgac 10080
gcgtgtggcc tcgaacaccg agcgaccctg cagcgacccg cttaacagcg tcaacagcgt 10140
gccgcagatc ccggggggca atgagatatg aaaaagcctg aactcaccgc gacgtctgtc 10200
gagaagtttc tgatcgaaaa gttcgacagc gtctccgacc tgatgcagct ctcggagggc 10260
gaagaatctc gtgctttcag cttcgatgta ggagggcgtg gatatgtcct gcgggtaaat 10320
agctgcgccg atggtttcta caaagatcgt tatgtttatc ggcactttgc atcggccgcg 10380
ctcccgattc cggaagtgct tgacattggg gaattcagcg agagcctgac ctattgcatc 10440
tcccgccgtg cacagggtgt cacgttgcaa gacctgcctg aaaccgaact gcccgctgtt 10500
ctgcagccgg tcgcggaggc catggatgcg atcgctgcgg ccgatcttag ccagacgagc 10560
gggttcggcc cattcggacc gcaaggaatc ggtcaataca ctacatggcg tgatttcata 10620
tgcgcgattg ctgatcccca tgtgtatcac tggcaaactg tgatggacga caccgtcagt 10680
gcgtccgtcg cgcaggctct cgatgagctg atgctttggg ccgaggactg ccccgaagtc 10740
cggcacctcg tgcacgcgga tttcggctcc aacaatgtcc tgacggacaa tggccgcata 10800
acagcggtca ttgactggag cgaggcgatg ttcggggatt cccaatacga ggtcgccaac 10860
atcttcttct ggaggccgtg gttggcttgt atggagcagc agacgcgcta cttcgagcgg 10920
aggcatccgg agcttgcagg atcgccgcgg ctccgggcgt atatgctccg cattggtctt 10980
gaccaactct atcagagctt ggttgacggc aatttcgatg atgcagcttg ggcgcagggt 11040
cgatgcgacg caatcgtccg atccggagcc gggactgtcg ggcgtacaca aatcgcccgc 11100
agaagcgcgg ccgtctggac cgatggctgt gtagaagtac tcgccgatag tggaaaccga 11160
cgccccagca ctcgtccgga tcgggagatg ggggaggcta actgaaacac ggaaggagac 11220
aataccggaa ggaacccgcg ctatgacggc aataaaaaga cagaataaaa cgcacgggtg 11280
ttgggtcgtt tgttcataaa cgcggggttc ggtcccaggg ctggcactct gtcgataccc 11340
caccgagacc ccattggggc caatacgccc gcgtttcttc cttttcccca ccccaccccc 11400
caagttcggg tgaaggccca gggctcgcag ccaacgtcgg ggcggcaggc cctgccatag 11460
ccactggccc cgtgggttag ggacggggtc ccccatgggg aatggtttat ggttcgtggg 11520
ggttattatt ttgggcgttg cgtggggtca ggtccacgac tggactgagc agacagaccc 11580
atggtttttg gatggcctgg gcatggaccg catgtactgg cgcgacacga acaccgggcg 11640
tctgtggctg ccaaacaccc ccgaccccca aaaaccaccg cgcggatttc tggcgtgcca 11700
agctagtcga ccaattctca tgtttgacag cttatcatcg cagatccggg caacgttgtt 11760
gccattgctg caggcgcaga actggtaggt atggaagatc tatacattga atcaatattg 11820
gcaattagcc atattagtca ttggttatat agcataaatc aatattggct attggccatt 11880
gcatacgttg tatctatatc ataatatgta catttatatt ggctcatgtc caatatgacc 11940
gccat                                                             11945



<210> 260
<211> 747
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p4372).

<400> 260
ggcggatgcg agcacttccg ctggtgcaag ccggtgggag gcggatccgg taccttagtc 60
accaactcca ccggtccccc atgcccacca tgcccggcgc ctgaggccgc cgggggacca 120
tcagtcttcc tgttcccccc aaaacccaag gacactctca tgatctcccg gacccctgag 180
gtcacgtgcg tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac 240
gtggatggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc 300
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag 360
tacaagtgca aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa 420
gccaaagggc agcctcgaga gccacaggtg tacaccctgc ccccatccca ggaggagatg 480
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc 540
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 600
gactccgacg gctccttctt cctctacagc aggctaaccg tggacaagag caggtggcag 660
gaggggaatg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacacag 720
aaaagcttgt ccctgtctct gggtaaa                                     747

<210> 261
<211> 249
<212> PRT
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p4372).

<400> 261
Gly Gly Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly Gly Gly Ser
 1               5                  10                  15      
Gly Thr Leu Val Thr Asn Ser Thr Gly Pro Pro Cys Pro Pro Cys Pro
            20                  25                  30          
Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
        35                  40                  45              
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
    50                  55                  60                  
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
65                  70                  75                  80  
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                85                  90                  95      
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
            100                 105                 110         
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
        115                 120                 125             
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
    130                 135                 140                 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
145                 150                 155                 160 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                165                 170                 175     
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
            180                 185                 190         
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
        195                 200                 205             
Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
    210                 215                 220                 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
225                 230                 235                 240 
Lys Ser Leu Ser Leu Ser Leu Gly Lys
                245                 


<210> 262
<211> 804
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p4372).

<400> 262
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggccggc 60
ggatgcgagc acttccgctg gtgcaagccg gtgggaggcg gatccggtac cttagtcacc 120
aactccaccg gtcccccatg cccaccatgc ccggcgcctg aggccgccgg gggaccatca 180
gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc 240
acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg 300
gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg 360
taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac 420
aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc 480
aaagggcagc ctcgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc 540
aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg 600
gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 660
tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag 720
gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaaa 780
agcttgtccc tgtctctggg taaa                                        804

<210> 263
<211> 268
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p4372).

<400> 263
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Gly Gly Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly
            20                  25                  30          
Gly Gly Ser Gly Thr Leu Val Thr Asn Ser Thr Gly Pro Pro Cys Pro
        35                  40                  45              
Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe
    50                  55                  60                  
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
65                  70                  75                  80  
Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe
                85                  90                  95      
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
            100                 105                 110         
Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
        115                 120                 125             
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
    130                 135                 140                 
Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala
145                 150                 155                 160 
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln
                165                 170                 175     
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
            180                 185                 190         
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
        195                 200                 205             
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
    210                 215                 220                 
Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu
225                 230                 235                 240 
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                245                 250                 255     
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
            260                 265             


<210> 264
<211> 11939
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p4372).

<400> 264
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggccggc ggatgcgagc acttccgctg 1680
gtgcaagccg gtgggaggcg gatccggtac cttagtcacc aactccaccg gtcccccatg 1740
cccaccatgc ccggcgcctg aggccgccgg gggaccatca gtcttcctgt tccccccaaa 1800
acccaaggac actctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt 1860
gagccaggaa gaccccgagg tccagttcaa ctggtacgtg gatggcgtgg aggtgcataa 1920
tgccaagaca aagccgcggg aggagcagtt caacagcacg taccgtgtgg tcagcgtcct 1980
caccgtcctg caccaggact ggctgaacgg caaggagtac aagtgcaagg tctccaacaa 2040
aggcctcccg tcctccatcg agaaaaccat ctccaaagcc aaagggcagc ctcgagagcc 2100
acaggtgtac accctgcccc catcccagga ggagatgacc aagaaccagg tcagcctgac 2160
ctgcctggtc aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca 2220
gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct 2280
ctacagcagg ctaaccgtgg acaagagcag gtggcaggag gggaatgtct tctcatgctc 2340
cgtgatgcat gaggctctgc acaaccacta cacacagaaa agcttgtccc tgtctctggg 2400
taaatgaggg cccgtttaaa cagatccaga catgataaga tacattgatg agtttggaca 2460
aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc 2520
tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt 2580
tatgtttcag gttcaggggg aggtgtggga ggttttttaa agcaagtaaa acctctacaa 2640
atgtggtatg gctgattatg atccggctgc ctcgcgcgtt tcggtgatga cggtgaaaac 2700
ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc 2760
agacaagccc gtcaggcgtc agcgggtgtt ggcgggtgtc ggggcgcagc catgaggtcg 2820
actctagagg atcgatgccc cgccccggac gaactaaacc tgactacgac atctctgccc 2880
cttcttcgcg gggcagtgca tgtaatccct tcagttggtt ggtacaactt gccaactggg 2940
ccctgttcca catgtgacac ggggggggac caaacacaaa ggggttctct gactgtagtt 3000
gacatcctta taaatggatg tgcacatttg ccaacactga gtggctttca tcctggagca 3060
gactttgcag tctgtggact gcaacacaac attgccttta tgtgtaactc ttggctgaag 3120
ctcttacacc aatgctgggg gacatgtacc tcccaggggc ccaggaagac tacgggaggc 3180
tacaccaacg tcaatcagag gggcctgtgt agctaccgat aagcggaccc tcaagagggc 3240
attagcaata gtgtttataa ggcccccttg ttaaccctaa acgggtagca tatgcttccc 3300
gggtagtagt atatactatc cagactaacc ctaattcaat agcatatgtt acccaacggg 3360
aagcatatgc tatcgaatta gggttagtaa aagggtccta aggaacagcg atatctccca 3420
ccccatgagc tgtcacggtt ttatttacat ggggtcagga ttccacgagg gtagtgaacc 3480
attttagtca caagggcagt ggctgaagat caaggagcgg gcagtgaact ctcctgaatc 3540
ttcgcctgct tcttcattct ccttcgttta gctaatagaa taactgctga gttgtgaaca 3600
gtaaggtgta tgtgaggtgc tcgaaaacaa ggtttcaggt gacgccccca gaataaaatt 3660
tggacggggg gttcagtggt ggcattgtgc tatgacacca atataaccct cacaaacccc 3720
ttgggcaata aatactagtg taggaatgaa acattctgaa tatctttaac aatagaaatc 3780
catggggtgg ggacaagccg taaagactgg atgtccatct cacacgaatt tatggctatg 3840
ggcaacacat aatcctagtg caatatgata ctggggttat taagatgtgt cccaggcagg 3900
gaccaagaca ggtgaaccat gttgttacac tctatttgta acaaggggaa agagagtgga 3960
cgccgacagc agcggactcc actggttgtc tctaacaccc ccgaaaatta aacggggctc 4020
cacgccaatg gggcccataa acaaagacaa gtggccactc ttttttttga aattgtggag 4080
tgggggcacg cgtcagcccc cacacgccgc cctgcggttt tggactgtaa aataagggtg 4140
taataacttg gctgattgta accccgctaa ccactgcggt caaaccactt gcccacaaaa 4200
ccactaatgg caccccgggg aatacctgca taagtaggtg ggcgggccaa gataggggcg 4260
cgattgctgc gatctggagg acaaattaca cacacttgcg cctgagcgcc aagcacaggg 4320
ttgttggtcc tcatattcac gaggtcgctg agagcacggt gggctaatgt tgccatgggt 4380
agcatatact acccaaatat ctggatagca tatgctatcc taatctatat ctgggtagca 4440
taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta 4500
tatgctatcc taatttatat ctgggtagca taggctatcc taatctatat ctgggtagca 4560
tatgctatcc taatctatat ctgggtagta tatgctatcc taatctgtat ccgggtagca 4620
tatgctatcc taatagagat tagggtagta tatgctatcc taatttatat ctgggtagca 4680
tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg gtagcatatg 4740
ctatcctaat ctatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg 4800
ctatcctaat ctatatctgg gtagtatatg ctatcctaat ttatatctgg gtagcatagg 4860
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg 4920
ctatcctaat ctgtatccgg gtagcatatg ctatcctcat gcatatacag tcagcatatg 4980
atacccagta gtagagtggg agtgctatcc tttgcatatg ccgccacctc ccaagggggc 5040
gtgaattttc gctgcttgtc cttttcctgc tggttgctcc cattcttagg tgaatttaag 5100
gaggccaggc taaagccgtc gcatgtctga ttgctcacca ggtaaatgtc gctaatgttt 5160
tccaacgcga gaaggtgttg agcgcggagc tgagtgacgt gacaacatgg gtatgcccaa 5220
ttgccccatg ttgggaggac gaaaatggtg acaagacaga tggccagaaa tacaccaaca 5280
gcacgcatga tgtctactgg ggatttattc tttagtgcgg gggaatacac ggcttttaat 5340
acgattgagg gcgtctccta acaagttaca tcactcctgc ccttcctcac cctcatctcc 5400
atcacctcct tcatctccgt catctccgtc atcaccctcc gcggcagccc cttccaccat 5460
aggtggaaac cagggaggca aatctactcc atcgtcaaag ctgcacacag tcaccctgat 5520
attgcaggta ggagcgggct ttgtcataac aaggtcctta atcgcatcct tcaaaacctc 5580
agcaaatata tgagtttgta aaaagaccat gaaataacag acaatggact cccttagcgg 5640
gccaggttgt gggccgggtc caggggccat tccaaagggg agacgactca atggtgtaag 5700
acgacattgt ggaatagcaa gggcagttcc tcgccttagg ttgtaaaggg aggtcttact 5760
acctccatat acgaacacac cggcgaccca agttccttcg tcggtagtcc tttctacgtg 5820
actcctagcc aggagagctc ttaaaccttc tgcaatgttc tcaaatttcg ggttggaacc 5880
tccttgacca cgatgctttt ccaaaccacc ctcctttttt gcgccctgcc tccatcaccc 5940
tgaccccggg gtccagtgct tgggccttct cctgggtcat ctgcggggcc ctgctctatc 6000
gctcccgggg gcacgtcagg ctcaccatct gggccacctt cttggtggta ttcaaaataa 6060
tcggcttccc ctacagggtg gaaaaatggc cttctacctg gagggggcct gcgcggtgga 6120
gacccggatg atgatgactg actactggga ctcctgggcc tcttttctcc acgtccacga 6180
cctctccccc tggctctttc acgacttccc cccctggctc tttcacgtcc tctaccccgg 6240
cggcctccac tacctcctcg accccggcct ccactacctc ctcgaccccg gcctccactg 6300
cctcctcgac cccggcctcc acctcctgct cctgcccctc ctgctcctgc ccctcctcct 6360
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6420
cctgcccctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctgcccct 6480
cctcctgctc ctgcccctcc tgcccctcct gctcctgccc ctcctgcccc tcctgctcct 6540
gcccctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc tcctgcccct 6600
cctgctcctg cccctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctgctcct 6660
gcccctcctg cccctcctgc ccctcctgct cctgcccctc ctcctgctcc tgcccctcct 6720
gcccctcctg cccctcctcc tgctcctgcc cctcctgccc ctcctcctgc tcctgcccct 6780
cctcctgctc ctgcccctcc tgcccctcct gcccctcctc ctgctcctgc ccctcctgcc 6840
cctcctcctg ctcctgcccc tcctcctgct cctgcccctc ctgcccctcc tgcccctcct 6900
cctgctcctg cccctcctcc tgctcctgcc cctcctgccc ctcctgcccc tcctgcccct 6960
cctcctgctc ctgcccctcc tcctgctcct gcccctcctg ctcctgcccc tcccgctcct 7020
gctcctgctc ctgttccacc gtgggtccct ttgcagccaa tgcaacttgg acgtttttgg 7080
ggtctccgga caccatctct atgtcttggc cctgatcctg agccgcccgg ggctcctggt 7140
cttccgcctc ctcgtcctcg tcctcttccc cgtcctcgtc catggttatc accccctctt 7200
ctttgaggtc cactgccgcc ggagccttct ggtccagatg tgtctccctt ctctcctagg 7260
ccatttccag gtcctgtacc tggcccctcg tcagacatga ttcacactaa aagagatcaa 7320
tagacatctt tattagacga cgctcagtga atacagggag tgcagactcc tgccccctcc 7380
aacagccccc ccaccctcat ccccttcatg gtcgctgtca gacagatcca ggtctgaaaa 7440
ttccccatcc tccgaaccat cctcgtcctc atcaccaatt actcgcagcc cggaaaactc 7500
ccgctgaaca tcctcaagat ttgcgtcctg agcctcaagc caggcctcaa attcctcgtc 7560
cccctttttg ctggacggta gggatgggga ttctcgggac ccctcctctt cctcttcaag 7620
gtcaccagac agagatgcta ctggggcaac ggaagaaaag ctgggtgcgg cctgtgagga 7680
tcagcttatc gatgataagc tgtcaaacat gagaattctt gaagacgaaa gggcctcgtg 7740
atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc 7800
acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat 7860
atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag 7920
agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt 7980
cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt 8040
gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc 8100
cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta 8160
tcccgtgttg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac 8220
ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa 8280
ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg 8340
atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc 8400
cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg 8460
atgcctgcag caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta 8520
gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg 8580
cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg 8640
tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc 8700
tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt 8760
gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt 8820
gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc 8880
atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag 8940
atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa 9000
aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg 9060
aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag 9120
ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg 9180
ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga 9240
tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc 9300
ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc 9360
acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga 9420
gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt 9480
cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg 9540
aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttgaagctgt 9600
ccctgatggt cgtcatctac ctgcctggac agcatggcct gcaacgcggg catcccgatg 9660
ccgccggaag cgagaagaat cataatgggg aaggccatcc agcctcgcgt cgcgaacgcc 9720
agcaagacgt agcccagcgc gtcggccccg agatgcgccg cgtgcggctg ctggagatgg 9780
cggacgcgat ggatatgttc tgccaagggt tggtttgcgc attcacagtt ctccgcaaga 9840
attgattggc tccaattctt ggagtggtga atccgttagc gaggtgccgc cctgcttcat 9900
ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg gaagaaatat atttgcatgt 9960
ctttagttct atgatgacac aaaccccgcc cagcgtcttg tcattggcga attcgaacac 10020
gcagatgcag tcggggcggc gcggtccgag gtccacttcg catattaagg tgacgcgtgt 10080
ggcctcgaac accgagcgac cctgcagcga cccgcttaac agcgtcaaca gcgtgccgca 10140
gatcccgggg ggcaatgaga tatgaaaaag cctgaactca ccgcgacgtc tgtcgagaag 10200
tttctgatcg aaaagttcga cagcgtctcc gacctgatgc agctctcgga gggcgaagaa 10260
tctcgtgctt tcagcttcga tgtaggaggg cgtggatatg tcctgcgggt aaatagctgc 10320
gccgatggtt tctacaaaga tcgttatgtt tatcggcact ttgcatcggc cgcgctcccg 10380
attccggaag tgcttgacat tggggaattc agcgagagcc tgacctattg catctcccgc 10440
cgtgcacagg gtgtcacgtt gcaagacctg cctgaaaccg aactgcccgc tgttctgcag 10500
ccggtcgcgg aggccatgga tgcgatcgct gcggccgatc ttagccagac gagcgggttc 10560
ggcccattcg gaccgcaagg aatcggtcaa tacactacat ggcgtgattt catatgcgcg 10620
attgctgatc cccatgtgta tcactggcaa actgtgatgg acgacaccgt cagtgcgtcc 10680
gtcgcgcagg ctctcgatga gctgatgctt tgggccgagg actgccccga agtccggcac 10740
ctcgtgcacg cggatttcgg ctccaacaat gtcctgacgg acaatggccg cataacagcg 10800
gtcattgact ggagcgaggc gatgttcggg gattcccaat acgaggtcgc caacatcttc 10860
ttctggaggc cgtggttggc ttgtatggag cagcagacgc gctacttcga gcggaggcat 10920
ccggagcttg caggatcgcc gcggctccgg gcgtatatgc tccgcattgg tcttgaccaa 10980
ctctatcaga gcttggttga cggcaatttc gatgatgcag cttgggcgca gggtcgatgc 11040
gacgcaatcg tccgatccgg agccgggact gtcgggcgta cacaaatcgc ccgcagaagc 11100
gcggccgtct ggaccgatgg ctgtgtagaa gtactcgccg atagtggaaa ccgacgcccc 11160
agcactcgtc cggatcggga gatgggggag gctaactgaa acacggaagg agacaatacc 11220
ggaaggaacc cgcgctatga cggcaataaa aagacagaat aaaacgcacg ggtgttgggt 11280
cgtttgttca taaacgcggg gttcggtccc agggctggca ctctgtcgat accccaccga 11340
gaccccattg gggccaatac gcccgcgttt cttccttttc cccaccccac cccccaagtt 11400
cgggtgaagg cccagggctc gcagccaacg tcggggcggc aggccctgcc atagccactg 11460
gccccgtggg ttagggacgg ggtcccccat ggggaatggt ttatggttcg tgggggttat 11520
tattttgggc gttgcgtggg gtcaggtcca cgactggact gagcagacag acccatggtt 11580
tttggatggc ctgggcatgg accgcatgta ctggcgcgac acgaacaccg ggcgtctgtg 11640
gctgccaaac acccccgacc cccaaaaacc accgcgcgga tttctggcgt gccaagctag 11700
tcgaccaatt ctcatgtttg acagcttatc atcgcagatc cgggcaacgt tgttgccatt 11760
gctgcaggcg cagaactggt aggtatggaa gatctataca ttgaatcaat attggcaatt 11820
agccatatta gtcattggtt atatagcata aatcaatatt ggctattggc cattgcatac 11880
gttgtatcta tatcataata tgtacattta tattggctca tgtccaatat gaccgccat  11939



<210> 265
<211> 747
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody without
      secretory signal (p4383).

<400> 265
ggcggatgcg agcacttccg ctggtgcaag ccggtgggtg gaggctccgg taccaacgtc 60
accgtctccg caggtccccc atgcccacca tgcccggcgc ctgaggccgc cgggggacca 120
tcagtcttcc tgttcccccc aaaacccaag gacactctca tgatctcccg gacccctgag 180
gtcacgtgcg tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac 240
gtggatggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc 300
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag 360
tacaagtgca aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa 420
gccaaagggc agcctcgaga gccacaggtg tacaccctgc ccccatccca ggaggagatg 480
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc 540
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 600
gactccgacg gctccttctt cctctacagc aggctaaccg tggacaagag caggtggcag 660
gaggggaatg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacacag 720
aaaagcttgt ccctgtctct gggtaaa                                     747

<210> 266
<211> 249
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      without secretory signal encoded by an in vitro
      synthesized DNA (p4383).

<400> 266
Gly Gly Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly Gly Gly Ser
 1               5                  10                  15      
Gly Thr Asn Val Thr Val Ser Ala Gly Pro Pro Cys Pro Pro Cys Pro
            20                  25                  30          
Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
        35                  40                  45              
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
    50                  55                  60                  
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
65                  70                  75                  80  
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                85                  90                  95      
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
            100                 105                 110         
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
        115                 120                 125             
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
    130                 135                 140                 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
145                 150                 155                 160 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                165                 170                 175     
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
            180                 185                 190         
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
        195                 200                 205             
Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
    210                 215                 220                 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
225                 230                 235                 240 
Lys Ser Leu Ser Leu Ser Leu Gly Lys
                245                 


<210> 267
<211> 804
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a melanocortin
      receptor binding alpha-MSH mimetibody with
      secretory signal (p4383).

<400> 267
atggcttggg tgtggacctt gctattcctg atggcggccg cccaaagtat acaggccggc 60
ggatgcgagc acttccgctg gtgcaagccg gtgggtggag gctccggtac caacgtcacc 120
gtctccgcag gtcccccatg cccaccatgc ccggcgcctg aggccgccgg gggaccatca 180
gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc 240
acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg 300
gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg 360
taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac 420
aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc 480
aaagggcagc ctcgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc 540
aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg 600
gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 660
tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag 720
gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaaa 780
agcttgtccc tgtctctggg taaa                                        804

<210> 268
<211> 268
<212> PRT
<213> Artificial Sequence

<220> 
<223> Melanocortin receptor binding alpha-MSH mimetibody
      with secretory signal encoded by an in vitro
      synthesized DNA (p4383).

<400> 268
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser
 1               5                  10                  15      
Ile Gln Ala Gly Gly Cys Glu His Phe Arg Trp Cys Lys Pro Val Gly
            20                  25                  30          
Gly Gly Ser Gly Thr Asn Val Thr Val Ser Ala Gly Pro Pro Cys Pro
        35                  40                  45              
Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe
    50                  55                  60                  
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
65                  70                  75                  80  
Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe
                85                  90                  95      
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
            100                 105                 110         
Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
        115                 120                 125             
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
    130                 135                 140                 
Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala
145                 150                 155                 160 
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln
                165                 170                 175     
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
            180                 185                 190         
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
        195                 200                 205             
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
    210                 215                 220                 
Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu
225                 230                 235                 240 
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                245                 250                 255     
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
            260                 265             


<210> 269
<211> 11939
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA with expression vector
      functions that encodes an alpha-MSH mimetibody (p4383).

<400> 269
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 60
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 120
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 180
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 240
atcaagtgta tcatatgcca agtccgcccc ctattgacgt caatgacggt aaatggcccg 300
cctggcatta tgcccagtac atgaccttac gggactttcc tacttggcag tacatctacg 360
tattagtcat cgctattacc atggtgatgc ggttttggca gtacaccaat gggcgtggat 420
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 480
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc 540
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 600
gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc 660
gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 720
acgtaagtac cgcctataga gtctataggc ccacctcctt ggcttcttat gcatgctata 780
ctgtttttgg cttggggtct atacaccccc gcttcctcat gttataggtg atggtatagc 840
ttagcctata ggtgtgggtt attgaccatt attgaccact cccctattgg tgacgatact 900
ttccattact aatccataac atggctcttt gccacaactc tctttattgg ctatatgcca 960
atacactgtc cttcagagac tgacacggac tctgtatttt tacaggatgg ggtctcattt 1020
attatttaca aattcacata tacaacacca ccgtccccag tgcccgcagc ttttattaaa 1080
cataacgtgg gatctccacg cgaatctcgg gtacgtgttc cggacatggg ctcttctccg 1140
gtagcggcgg agcttctaca tccgagccct gctcccatgc ctccagcgac tcatggtcgc 1200
tcggcagctc cttgctccta acagtggagg ccagacttag gcacagcacg atgcccacca 1260
ccaccagtgt gccgcacaag gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg 1320
agcgggcttg caccgctgac gcatttggaa gacttaaggc agcggcagaa gaagatgcag 1380
gcagctgagt tgttgtgttc tgataagagt cagaggtaac tcccgttgcg gtgctgttaa 1440
cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc cgcgcgcgcc accagacata 1500
atagctgaca gactaacaga ctgttccttt ccatgggtct tttctgcagt caccgtcctt 1560
agatctgtct agaagctggg taccagctgc tagcgccacc atggcttggg tgtggacctt 1620
gctattcctg atggcggccg cccaaagtat acaggccggc ggatgcgagc acttccgctg 1680
gtgcaagccg gtgggtggag gctccggtac caacgtcacc gtctccgcag gtcccccatg 1740
cccaccatgc ccggcgcctg aggccgccgg gggaccatca gtcttcctgt tccccccaaa 1800
acccaaggac actctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt 1860
gagccaggaa gaccccgagg tccagttcaa ctggtacgtg gatggcgtgg aggtgcataa 1920
tgccaagaca aagccgcggg aggagcagtt caacagcacg taccgtgtgg tcagcgtcct 1980
caccgtcctg caccaggact ggctgaacgg caaggagtac aagtgcaagg tctccaacaa 2040
aggcctcccg tcctccatcg agaaaaccat ctccaaagcc aaagggcagc ctcgagagcc 2100
acaggtgtac accctgcccc catcccagga ggagatgacc aagaaccagg tcagcctgac 2160
ctgcctggtc aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca 2220
gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct 2280
ctacagcagg ctaaccgtgg acaagagcag gtggcaggag gggaatgtct tctcatgctc 2340
cgtgatgcat gaggctctgc acaaccacta cacacagaaa agcttgtccc tgtctctggg 2400
taaatgaggg cccgtttaaa cagatccaga catgataaga tacattgatg agtttggaca 2460
aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc 2520
tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt 2580
tatgtttcag gttcaggggg aggtgtggga ggttttttaa agcaagtaaa acctctacaa 2640
atgtggtatg gctgattatg atccggctgc ctcgcgcgtt tcggtgatga cggtgaaaac 2700
ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc 2760
agacaagccc gtcaggcgtc agcgggtgtt ggcgggtgtc ggggcgcagc catgaggtcg 2820
actctagagg atcgatgccc cgccccggac gaactaaacc tgactacgac atctctgccc 2880
cttcttcgcg gggcagtgca tgtaatccct tcagttggtt ggtacaactt gccaactggg 2940
ccctgttcca catgtgacac ggggggggac caaacacaaa ggggttctct gactgtagtt 3000
gacatcctta taaatggatg tgcacatttg ccaacactga gtggctttca tcctggagca 3060
gactttgcag tctgtggact gcaacacaac attgccttta tgtgtaactc ttggctgaag 3120
ctcttacacc aatgctgggg gacatgtacc tcccaggggc ccaggaagac tacgggaggc 3180
tacaccaacg tcaatcagag gggcctgtgt agctaccgat aagcggaccc tcaagagggc 3240
attagcaata gtgtttataa ggcccccttg ttaaccctaa acgggtagca tatgcttccc 3300
gggtagtagt atatactatc cagactaacc ctaattcaat agcatatgtt acccaacggg 3360
aagcatatgc tatcgaatta gggttagtaa aagggtccta aggaacagcg atatctccca 3420
ccccatgagc tgtcacggtt ttatttacat ggggtcagga ttccacgagg gtagtgaacc 3480
attttagtca caagggcagt ggctgaagat caaggagcgg gcagtgaact ctcctgaatc 3540
ttcgcctgct tcttcattct ccttcgttta gctaatagaa taactgctga gttgtgaaca 3600
gtaaggtgta tgtgaggtgc tcgaaaacaa ggtttcaggt gacgccccca gaataaaatt 3660
tggacggggg gttcagtggt ggcattgtgc tatgacacca atataaccct cacaaacccc 3720
ttgggcaata aatactagtg taggaatgaa acattctgaa tatctttaac aatagaaatc 3780
catggggtgg ggacaagccg taaagactgg atgtccatct cacacgaatt tatggctatg 3840
ggcaacacat aatcctagtg caatatgata ctggggttat taagatgtgt cccaggcagg 3900
gaccaagaca ggtgaaccat gttgttacac tctatttgta acaaggggaa agagagtgga 3960
cgccgacagc agcggactcc actggttgtc tctaacaccc ccgaaaatta aacggggctc 4020
cacgccaatg gggcccataa acaaagacaa gtggccactc ttttttttga aattgtggag 4080
tgggggcacg cgtcagcccc cacacgccgc cctgcggttt tggactgtaa aataagggtg 4140
taataacttg gctgattgta accccgctaa ccactgcggt caaaccactt gcccacaaaa 4200
ccactaatgg caccccgggg aatacctgca taagtaggtg ggcgggccaa gataggggcg 4260
cgattgctgc gatctggagg acaaattaca cacacttgcg cctgagcgcc aagcacaggg 4320
ttgttggtcc tcatattcac gaggtcgctg agagcacggt gggctaatgt tgccatgggt 4380
agcatatact acccaaatat ctggatagca tatgctatcc taatctatat ctgggtagca 4440
taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta 4500
tatgctatcc taatttatat ctgggtagca taggctatcc taatctatat ctgggtagca 4560
tatgctatcc taatctatat ctgggtagta tatgctatcc taatctgtat ccgggtagca 4620
tatgctatcc taatagagat tagggtagta tatgctatcc taatttatat ctgggtagca 4680
tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg gtagcatatg 4740
ctatcctaat ctatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg 4800
ctatcctaat ctatatctgg gtagtatatg ctatcctaat ttatatctgg gtagcatagg 4860
ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg 4920
ctatcctaat ctgtatccgg gtagcatatg ctatcctcat gcatatacag tcagcatatg 4980
atacccagta gtagagtggg agtgctatcc tttgcatatg ccgccacctc ccaagggggc 5040
gtgaattttc gctgcttgtc cttttcctgc tggttgctcc cattcttagg tgaatttaag 5100
gaggccaggc taaagccgtc gcatgtctga ttgctcacca ggtaaatgtc gctaatgttt 5160
tccaacgcga gaaggtgttg agcgcggagc tgagtgacgt gacaacatgg gtatgcccaa 5220
ttgccccatg ttgggaggac gaaaatggtg acaagacaga tggccagaaa tacaccaaca 5280
gcacgcatga tgtctactgg ggatttattc tttagtgcgg gggaatacac ggcttttaat 5340
acgattgagg gcgtctccta acaagttaca tcactcctgc ccttcctcac cctcatctcc 5400
atcacctcct tcatctccgt catctccgtc atcaccctcc gcggcagccc cttccaccat 5460
aggtggaaac cagggaggca aatctactcc atcgtcaaag ctgcacacag tcaccctgat 5520
attgcaggta ggagcgggct ttgtcataac aaggtcctta atcgcatcct tcaaaacctc 5580
agcaaatata tgagtttgta aaaagaccat gaaataacag acaatggact cccttagcgg 5640
gccaggttgt gggccgggtc caggggccat tccaaagggg agacgactca atggtgtaag 5700
acgacattgt ggaatagcaa gggcagttcc tcgccttagg ttgtaaaggg aggtcttact 5760
acctccatat acgaacacac cggcgaccca agttccttcg tcggtagtcc tttctacgtg 5820
actcctagcc aggagagctc ttaaaccttc tgcaatgttc tcaaatttcg ggttggaacc 5880
tccttgacca cgatgctttt ccaaaccacc ctcctttttt gcgccctgcc tccatcaccc 5940
tgaccccggg gtccagtgct tgggccttct cctgggtcat ctgcggggcc ctgctctatc 6000
gctcccgggg gcacgtcagg ctcaccatct gggccacctt cttggtggta ttcaaaataa 6060
tcggcttccc ctacagggtg gaaaaatggc cttctacctg gagggggcct gcgcggtgga 6120
gacccggatg atgatgactg actactggga ctcctgggcc tcttttctcc acgtccacga 6180
cctctccccc tggctctttc acgacttccc cccctggctc tttcacgtcc tctaccccgg 6240
cggcctccac tacctcctcg accccggcct ccactacctc ctcgaccccg gcctccactg 6300
cctcctcgac cccggcctcc acctcctgct cctgcccctc ctgctcctgc ccctcctcct 6360
gctcctgccc ctcctgcccc tcctgctcct gcccctcctg cccctcctgc tcctgcccct 6420
cctgcccctc ctgctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctgcccct 6480
cctcctgctc ctgcccctcc tgcccctcct gctcctgccc ctcctgcccc tcctgctcct 6540
gcccctcctg cccctcctgc tcctgcccct cctgctcctg cccctcctgc tcctgcccct 6600
cctgctcctg cccctcctgc ccctcctgcc cctcctcctg ctcctgcccc tcctgctcct 6660
gcccctcctg cccctcctgc ccctcctgct cctgcccctc ctcctgctcc tgcccctcct 6720
gcccctcctg cccctcctcc tgctcctgcc cctcctgccc ctcctcctgc tcctgcccct 6780
cctcctgctc ctgcccctcc tgcccctcct gcccctcctc ctgctcctgc ccctcctgcc 6840
cctcctcctg ctcctgcccc tcctcctgct cctgcccctc ctgcccctcc tgcccctcct 6900
cctgctcctg cccctcctcc tgctcctgcc cctcctgccc ctcctgcccc tcctgcccct 6960
cctcctgctc ctgcccctcc tcctgctcct gcccctcctg ctcctgcccc tcccgctcct 7020
gctcctgctc ctgttccacc gtgggtccct ttgcagccaa tgcaacttgg acgtttttgg 7080
ggtctccgga caccatctct atgtcttggc cctgatcctg agccgcccgg ggctcctggt 7140
cttccgcctc ctcgtcctcg tcctcttccc cgtcctcgtc catggttatc accccctctt 7200
ctttgaggtc cactgccgcc ggagccttct ggtccagatg tgtctccctt ctctcctagg 7260
ccatttccag gtcctgtacc tggcccctcg tcagacatga ttcacactaa aagagatcaa 7320
tagacatctt tattagacga cgctcagtga atacagggag tgcagactcc tgccccctcc 7380
aacagccccc ccaccctcat ccccttcatg gtcgctgtca gacagatcca ggtctgaaaa 7440
ttccccatcc tccgaaccat cctcgtcctc atcaccaatt actcgcagcc cggaaaactc 7500
ccgctgaaca tcctcaagat ttgcgtcctg agcctcaagc caggcctcaa attcctcgtc 7560
cccctttttg ctggacggta gggatgggga ttctcgggac ccctcctctt cctcttcaag 7620
gtcaccagac agagatgcta ctggggcaac ggaagaaaag ctgggtgcgg cctgtgagga 7680
tcagcttatc gatgataagc tgtcaaacat gagaattctt gaagacgaaa gggcctcgtg 7740
atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc 7800
acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat 7860
atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag 7920
agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt 7980
cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt 8040
gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc 8100
cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta 8160
tcccgtgttg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac 8220
ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa 8280
ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg 8340
atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc 8400
cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg 8460
atgcctgcag caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta 8520
gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg 8580
cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg 8640
tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc 8700
tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt 8760
gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt 8820
gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc 8880
atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag 8940
atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa 9000
aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg 9060
aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag 9120
ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg 9180
ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga 9240
tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc 9300
ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc 9360
acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga 9420
gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt 9480
cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg 9540
aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttgaagctgt 9600
ccctgatggt cgtcatctac ctgcctggac agcatggcct gcaacgcggg catcccgatg 9660
ccgccggaag cgagaagaat cataatgggg aaggccatcc agcctcgcgt cgcgaacgcc 9720
agcaagacgt agcccagcgc gtcggccccg agatgcgccg cgtgcggctg ctggagatgg 9780
cggacgcgat ggatatgttc tgccaagggt tggtttgcgc attcacagtt ctccgcaaga 9840
attgattggc tccaattctt ggagtggtga atccgttagc gaggtgccgc cctgcttcat 9900
ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg gaagaaatat atttgcatgt 9960
ctttagttct atgatgacac aaaccccgcc cagcgtcttg tcattggcga attcgaacac 10020
gcagatgcag tcggggcggc gcggtccgag gtccacttcg catattaagg tgacgcgtgt 10080
ggcctcgaac accgagcgac cctgcagcga cccgcttaac agcgtcaaca gcgtgccgca 10140
gatcccgggg ggcaatgaga tatgaaaaag cctgaactca ccgcgacgtc tgtcgagaag 10200
tttctgatcg aaaagttcga cagcgtctcc gacctgatgc agctctcgga gggcgaagaa 10260
tctcgtgctt tcagcttcga tgtaggaggg cgtggatatg tcctgcgggt aaatagctgc 10320
gccgatggtt tctacaaaga tcgttatgtt tatcggcact ttgcatcggc cgcgctcccg 10380
attccggaag tgcttgacat tggggaattc agcgagagcc tgacctattg catctcccgc 10440
cgtgcacagg gtgtcacgtt gcaagacctg cctgaaaccg aactgcccgc tgttctgcag 10500
ccggtcgcgg aggccatgga tgcgatcgct gcggccgatc ttagccagac gagcgggttc 10560
ggcccattcg gaccgcaagg aatcggtcaa tacactacat ggcgtgattt catatgcgcg 10620
attgctgatc cccatgtgta tcactggcaa actgtgatgg acgacaccgt cagtgcgtcc 10680
gtcgcgcagg ctctcgatga gctgatgctt tgggccgagg actgccccga agtccggcac 10740
ctcgtgcacg cggatttcgg ctccaacaat gtcctgacgg acaatggccg cataacagcg 10800
gtcattgact ggagcgaggc gatgttcggg gattcccaat acgaggtcgc caacatcttc 10860
ttctggaggc cgtggttggc ttgtatggag cagcagacgc gctacttcga gcggaggcat 10920
ccggagcttg caggatcgcc gcggctccgg gcgtatatgc tccgcattgg tcttgaccaa 10980
ctctatcaga gcttggttga cggcaatttc gatgatgcag cttgggcgca gggtcgatgc 11040
gacgcaatcg tccgatccgg agccgggact gtcgggcgta cacaaatcgc ccgcagaagc 11100
gcggccgtct ggaccgatgg ctgtgtagaa gtactcgccg atagtggaaa ccgacgcccc 11160
agcactcgtc cggatcggga gatgggggag gctaactgaa acacggaagg agacaatacc 11220
ggaaggaacc cgcgctatga cggcaataaa aagacagaat aaaacgcacg ggtgttgggt 11280
cgtttgttca taaacgcggg gttcggtccc agggctggca ctctgtcgat accccaccga 11340
gaccccattg gggccaatac gcccgcgttt cttccttttc cccaccccac cccccaagtt 11400
cgggtgaagg cccagggctc gcagccaacg tcggggcggc aggccctgcc atagccactg 11460
gccccgtggg ttagggacgg ggtcccccat ggggaatggt ttatggttcg tgggggttat 11520
tattttgggc gttgcgtggg gtcaggtcca cgactggact gagcagacag acccatggtt 11580
tttggatggc ctgggcatgg accgcatgta ctggcgcgac acgaacaccg ggcgtctgtg 11640
gctgccaaac acccccgacc cccaaaaacc accgcgcgga tttctggcgt gccaagctag 11700
tcgaccaatt ctcatgtttg acagcttatc atcgcagatc cgggcaacgt tgttgccatt 11760
gctgcaggcg cagaactggt aggtatggaa gatctataca ttgaatcaat attggcaatt 11820
agccatatta gtcattggtt atatagcata aatcaatatt ggctattggc cattgcatac 11880
gttgtatcta tatcataata tgtacattta tattggctca tgtccaatat gaccgccat  11939



<210> 270
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a constrained
      peptide sequence.

<400> 270
ggcggatgcg agcacttccg ctggtgcaag ccggtg                           36

<210> 271
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an in vitro
      synthesized DNA.

<400> 271
Gly Gly Cys Glu His Phe Arg Trp Cys Lys Pro Val
 1               5                  10          


<210> 272
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a flexible
      peptide sequence.

<400> 272
ggatccggt                                                         9

<210> 273
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible peptide encoded by an in vitro
      synthesized DNA.

<400> 273
Gly Ser Gly
 1          


<210> 274
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro mutagenized Homo sapien DNA encoding a V2
      peptide sequence comprising a V to N substitution to
      increase N-linked glycosylation and a S to T
      substitution to increase O-linked glycosylation.

<400> 274
accttagtca ccaactccac c                                           21

<210> 275
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutagenized Homo sapien V2 peptide comprising a
      V to N substitution to increase N-linked
      glycosylation and a S to T subsutition to improve
      O-linked glycosylation and encoded by an in vitro
      mutagenized Homo sapien DNA.

<400> 275
Thr Leu Val Thr Asn Ser Thr
 1               5          


<210> 276
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a flexible
      peptide sequence.

<400> 276
ggaggcggat ccggt                                                  15

<210> 277
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible peptide encoded by an in vitro
      synthesized DNA.

<400> 277
Gly Gly Gly Ser Gly
 1               5  


<210> 278
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro mutagenized Homo sapien DNA encoding a V2
      peptide sequence comprising a L to N substitution to
      increase N-linked glycosylation and a S to A
      substitution to increase N-linked glycosylation.

<400> 278
accaacgtca ccgtctccgc a                                           21

<210> 279
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutagenized Homo sapien V2 peptide comprising a
      V to N substitution to increase N-linked
      glycosylation and a S to T subsutition to increase
      O-linked glycosylation and encoded by an in vitro
      mutagenized Homo sapien DNA.

<400> 279
Thr Asn Val Thr Val Ser Ala
 1               5          


<210> 280
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> In vitro synthesized DNA encoding a flexible
      peptide sequence.

<400> 280
ggtcccccat gcccaccatg cccg                                        24

<210> 281
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible peptide encoded by an in vitro
      synthesized DNA.

<400> 281
Gly Pro Pro Cys Pro Pro Cys Pro
 1               5              

<210> 282
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Constrained peptide encoded by an in vitro
      synthesized DNA

<400> 282
Gly Gly Cys Glu His Phe Arg Trp Cys Lys Pro Val
 1               5                  10
CEN5080PCT1




205


