
                                SEQUENCE LISTING

<110> Pedersen, Anders Hjelholt
      Hejnaes, Kim Ry

<120> Agents and composition for treatment of
  steroid dependent cancers
  

<130> P1869PC00

<150> PA 2008 00609       
<151> 2008-04-30  

<160> 7

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 4655
<212> PRT
<213> Homo Sapiens

<400> 1
Met Asp Arg Gly Pro Ala Ala Val Ala Cys Thr Leu Leu Leu Ala Leu
 1               5                  10                  15      
Val Ala Cys Leu Ala Pro Ala Ser Gly Gln Glu Cys Asp Ser Ala His
            20                  25                  30          
Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala Asp Trp Arg Cys Asp
        35                  40                  45              
Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu Ile Gly Cys Ala Val
    50                  55                  60                  
Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln Ser Glu Gly Gln Cys
65                  70                  75                  80  
Ile Pro Asn Ser Trp Val Cys Asp Gln Asp Gln Asp Cys Asp Asp Gly
                85                  90                  95      
Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr Cys Ser Ser His Gln
            100                 105                 110         
Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser Glu Tyr Arg Cys Asp
        115                 120                 125             
His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu Asn Asp Cys Gln Tyr
    130                 135                 140                 
Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly Ala Cys Tyr Asn Thr
145                 150                 155                 160 
Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg Asp Ser Ser Asp Glu
                165                 170                 175     
Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu Phe Ser Cys Gly Asn
            180                 185                 190         
Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys
        195                 200                 205             
Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr Pro Thr Cys Gly Gly
    210                 215                 220                 
Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln Asn Trp Val
225                 230                 235                 240 
Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu Asp Gly Cys
                245                 250                 255     
Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg Glu Trp Ser
            260                 265                 270         
Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val Cys Asp Gly
        275                 280                 285             
Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr Ser Thr Gly
    290                 295                 300                 
Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys Gln Tyr Gln
305                 310                 315                 320 
Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro Pro Gly Tyr
                325                 330                 335     
Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe Asp Asp Cys
            340                 345                 350         
Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Pro Gly Arg
        355                 360                 365             
His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln Tyr
    370                 375                 380                 
Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile Phe Ser Asn
385                 390                 395                 400 
Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser Phe Arg Ile
                405                 410                 415     
Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val Ala Phe His
            420                 425                 430         
Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln Asn Lys Val
        435                 440                 445             
Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val Leu Asn Val
    450                 455                 460                 
Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val Asn Asn Lys
465                 470                 475                 480 
Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met Val Asn Leu
                485                 490                 495     
Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro
            500                 505                 510         
Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu Phe Phe Ser Asp
        515                 520                 525             
Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg Ala Phe Met Asp
    530                 535                 540                 
Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu Gly Trp Pro Ala
545                 550                 555                 560 
Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr Trp Val Asp Ser
                565                 570                 575     
Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile Gln Arg Lys
            580                 585                 590         
Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro Phe Gly Val Ser
        595                 600                 605             
Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val
    610                 615                 620                 
Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln Val Tyr Tyr Gln
625                 630                 635                 640 
Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His Ser Leu Arg Gln
                645                 650                 655     
Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly Gly Cys Glu Gln
            660                 665                 670         
Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly Leu Gly Phe Arg
        675                 680                 685             
Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp Glu Arg His Cys
    690                 695                 700                 
Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln Val Ala Ile Arg
705                 710                 715                 720 
Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met Val Pro Val
                725                 730                 735     
Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe Asp Ala Gln Asp
            740                 745                 750         
Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met Ile Phe Lys Gln
        755                 760                 765             
Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala Asn Arg Val Glu
    770                 775                 780                 
Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys Asn Leu Tyr Trp
785                 790                 795                 800 
Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg Leu Ala Asp Lys
                805                 810                 815     
Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro Arg Ser Val Val
            820                 825                 830         
Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp Trp Phe Arg Pro
        835                 840                 845             
Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu Leu Pro Val
    850                 855                 860                 
Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala Ile Asp Trp Ala
865                 870                 875                 880 
Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp Lys Ile Glu His
                885                 890                 895     
Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu Gly His Ile Glu Gln
            900                 905                 910         
Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly Glu His Leu Phe Phe
        915                 920                 925             
Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg Lys Ala Asp Gly
    930                 935                 940                 
Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala Tyr Ile Leu His Leu
945                 950                 955                 960 
Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser Asn Ala Cys Asn Gln
                965                 970                 975     
Pro Thr His Pro Asn Gly Asp Cys Ser His Phe Cys Phe Pro Val Pro
            980                 985                 990         
Asn Phe Gln Arg Val Cys Gly Cys Pro Tyr Gly Met Arg Leu Ala Ser
        995                 1000                1005            
Asn His Leu Thr Cys Glu Gly Asp Pro Thr Asn Glu Pro Pro Thr Glu
    1010                1015                1020                
Gln Cys Gly Leu Phe Ser Phe Pro Cys Lys Asn Gly Arg Cys Val Pro
1025                1030                1035               1040 
Asn Tyr Tyr Leu Cys Asp Gly Val Asp Asp Cys His Asp Asn Ser Asp
                1045                1050                1055    
Glu Gln Leu Cys Gly Thr Leu Asn Asn Thr Cys Ser Ser Ser Ala Phe
            1060                1065                1070        
Thr Cys Gly His Gly Glu Cys Ile Pro Ala His Trp Arg Cys Asp Lys
        1075                1080                1085            
Arg Asn Asp Cys Val Asp Gly Ser Asp Glu His Asn Cys Pro Thr His
    1090                1095                1100                
Ala Pro Ala Ser Cys Leu Asp Thr Gln Tyr Thr Cys Asp Asn His Gln
1105                1110                1115               1120 
Cys Ile Ser Lys Asn Trp Val Cys Asp Thr Asp Asn Asp Cys Gly Asp
                1125                1130                1135    
Gly Ser Asp Glu Lys Asn Cys Asn Ser Thr Glu Thr Cys Gln Pro Ser
            1140                1145                1150        
Gln Phe Asn Cys Pro Asn His Arg Cys Ile Asp Leu Ser Phe Val Cys
        1155                1160                1165            
Asp Gly Asp Lys Asp Cys Val Asp Gly Ser Asp Glu Val Gly Cys Val
    1170                1175                1180                
Leu Asn Cys Thr Ala Ser Gln Phe Lys Cys Ala Ser Gly Asp Lys Cys
1185                1190                1195               1200 
Ile Gly Val Thr Asn Arg Cys Asp Gly Val Phe Asp Cys Ser Asp Asn
                1205                1210                1215    
Ser Asp Glu Ala Gly Cys Pro Thr Arg Pro Pro Gly Met Cys His Ser
            1220                1225                1230        
Asp Glu Phe Gln Cys Gln Glu Asp Gly Ile Cys Ile Pro Asn Phe Trp
        1235                1240                1245            
Glu Cys Asp Gly His Pro Asp Cys Leu Tyr Gly Ser Asp Glu His Asn
    1250                1255                1260                
Ala Cys Val Pro Lys Thr Cys Pro Ser Ser Tyr Phe His Cys Asp Asn
1265                1270                1275               1280 
Gly Asn Cys Ile His Arg Ala Trp Leu Cys Asp Arg Asp Asn Asp Cys
                1285                1290                1295    
Gly Asp Met Ser Asp Glu Lys Asp Cys Pro Thr Gln Pro Phe Arg Cys
            1300                1305                1310        
Pro Ser Trp Gln Trp Gln Cys Leu Gly His Asn Ile Cys Val Asn Leu
        1315                1320                1325            
Ser Val Val Cys Asp Gly Ile Phe Asp Cys Pro Asn Gly Thr Asp Glu
    1330                1335                1340                
Ser Pro Leu Cys Asn Gly Asn Ser Cys Ser Asp Phe Asn Gly Gly Cys
1345                1350                1355               1360 
Thr His Glu Cys Val Gln Glu Pro Phe Gly Ala Lys Cys Leu Cys Pro
                1365                1370                1375    
Leu Gly Phe Leu Leu Ala Asn Asp Ser Lys Thr Cys Glu Asp Ile Asp
            1380                1385                1390        
Glu Cys Asp Ile Leu Gly Ser Cys Ser Gln His Cys Tyr Asn Met Arg
        1395                1400                1405            
Gly Ser Phe Arg Cys Ser Cys Asp Thr Gly Tyr Met Leu Glu Ser Asp
    1410                1415                1420                
Gly Arg Thr Cys Lys Val Thr Ala Ser Glu Ser Leu Leu Leu Leu Val
1425                1430                1435               1440 
Ala Ser Gln Asn Lys Ile Ile Ala Asp Ser Val Thr Ser Gln Val His
                1445                1450                1455    
Asn Ile Tyr Ser Leu Val Glu Asn Gly Ser Tyr Ile Val Ala Val Asp
            1460                1465                1470        
Phe Asp Ser Ile Ser Gly Arg Ile Phe Trp Ser Asp Ala Thr Gln Gly
        1475                1480                1485            
Lys Thr Trp Ser Ala Phe Gln Asn Gly Thr Asp Arg Arg Val Val Phe
    1490                1495                1500                
Asp Ser Ser Ile Ile Leu Thr Glu Thr Ile Ala Ile Asp Trp Val Gly
1505                1510                1515               1520 
Arg Asn Leu Tyr Trp Thr Asp Tyr Ala Leu Glu Thr Ile Glu Val Ser
                1525                1530                1535    
Lys Ile Asp Gly Ser His Arg Thr Val Leu Ile Ser Lys Asn Leu Thr
            1540                1545                1550        
Asn Pro Arg Gly Leu Ala Leu Asp Pro Arg Met Asn Glu His Leu Leu
        1555                1560                1565            
Phe Trp Ser Asp Trp Gly His His Pro Arg Ile Glu Arg Ala Ser Met
    1570                1575                1580                
Asp Gly Ser Met Arg Thr Val Ile Val Gln Asp Lys Ile Phe Trp Pro
1585                1590                1595               1600 
Cys Gly Leu Thr Ile Asp Tyr Pro Asn Arg Leu Leu Tyr Phe Met Asp
                1605                1610                1615    
Ser Tyr Leu Asp Tyr Met Asp Phe Cys Asp Tyr Asn Gly His His Arg
            1620                1625                1630        
Arg Gln Val Ile Ala Ser Asp Leu Ile Ile Arg His Pro Tyr Ala Leu
        1635                1640                1645            
Thr Leu Phe Glu Asp Ser Val Tyr Trp Thr Asp Arg Ala Thr Arg Arg
    1650                1655                1660                
Val Met Arg Ala Asn Lys Trp His Gly Gly Asn Gln Ser Val Val Met
1665                1670                1675               1680 
Tyr Asn Ile Gln Trp Pro Leu Gly Ile Val Ala Val His Pro Ser Lys
                1685                1690                1695    
Gln Pro Asn Ser Val Asn Pro Cys Ala Phe Ser Arg Cys Ser His Leu
            1700                1705                1710        
Cys Leu Leu Ser Ser Gln Gly Pro His Phe Tyr Ser Cys Val Cys Pro
        1715                1720                1725            
Ser Gly Trp Ser Leu Ser Pro Asp Leu Leu Asn Cys Leu Arg Asp Asp
    1730                1735                1740                
Gln Pro Phe Leu Ile Thr Val Arg Gln His Ile Ile Phe Gly Ile Ser
1745                1750                1755               1760 
Leu Asn Pro Glu Val Lys Ser Asn Asp Ala Met Val Pro Ile Ala Gly
                1765                1770                1775    
Ile Gln Asn Gly Leu Asp Val Glu Phe Asp Asp Ala Glu Gln Tyr Ile
            1780                1785                1790        
Tyr Trp Val Glu Asn Pro Gly Glu Ile His Arg Val Lys Thr Asp Gly
        1795                1800                1805            
Thr Asn Arg Thr Val Phe Ala Ser Ile Ser Met Val Gly Pro Ser Met
    1810                1815                1820                
Asn Leu Ala Leu Asp Trp Ile Ser Arg Asn Leu Tyr Ser Thr Asn Pro
1825                1830                1835               1840 
Arg Thr Gln Ser Ile Glu Val Leu Thr Leu His Gly Asp Ile Arg Tyr
                1845                1850                1855    
Arg Lys Thr Leu Ile Ala Asn Asp Gly Thr Ala Leu Gly Val Gly Phe
            1860                1865                1870        
Pro Ile Gly Ile Thr Val Asp Pro Ala Arg Gly Lys Leu Tyr Trp Ser
        1875                1880                1885            
Asp Gln Gly Thr Asp Ser Gly Val Pro Ala Lys Ile Ala Ser Ala Asn
    1890                1895                1900                
Met Asp Gly Thr Ser Val Lys Thr Leu Phe Thr Gly Asn Leu Glu His
1905                1910                1915               1920 
Leu Glu Cys Val Thr Leu Asp Ile Glu Glu Gln Lys Leu Tyr Trp Ala
                1925                1930                1935    
Val Thr Gly Arg Gly Val Ile Glu Arg Gly Asn Val Asp Gly Thr Asp
            1940                1945                1950        
Arg Met Ile Leu Val His Gln Leu Ser His Pro Trp Gly Ile Ala Val
        1955                1960                1965            
His Asp Ser Phe Leu Tyr Tyr Thr Asp Glu Gln Tyr Glu Val Ile Glu
    1970                1975                1980                
Arg Val Asp Lys Ala Thr Gly Ala Asn Lys Ile Val Leu Arg Asp Asn
1985                1990                1995               2000 
Val Pro Asn Leu Arg Gly Leu Gln Val Tyr His Arg Arg Asn Ala Ala
                2005                2010                2015    
Glu Ser Ser Asn Gly Cys Ser Asn Asn Met Asn Ala Cys Gln Gln Ile
            2020                2025                2030        
Cys Leu Pro Val Pro Gly Gly Leu Phe Ser Cys Ala Cys Ala Thr Gly
        2035                2040                2045            
Phe Lys Leu Asn Pro Asp Asn Arg Ser Cys Ser Pro Tyr Asn Ser Phe
    2050                2055                2060                
Ile Val Val Ser Met Leu Ser Ala Ile Arg Gly Phe Ser Leu Glu Leu
2065                2070                2075               2080 
Ser Asp His Ser Glu Thr Met Val Pro Val Ala Gly Gln Gly Arg Asn
                2085                2090                2095    
Ala Leu His Val Asp Val Asp Val Ser Ser Gly Phe Ile Tyr Trp Cys
            2100                2105                2110        
Asp Phe Ser Ser Ser Val Ala Ser Asp Asn Ala Ile Arg Arg Ile Lys
        2115                2120                2125            
Pro Asp Gly Ser Ser Leu Met Asn Ile Val Thr His Gly Ile Gly Glu
    2130                2135                2140                
Asn Gly Val Arg Gly Ile Ala Val Asp Trp Val Ala Gly Asn Leu Tyr
2145                2150                2155               2160 
Phe Thr Asn Ala Phe Val Ser Glu Thr Leu Ile Glu Val Leu Arg Ile
                2165                2170                2175    
Asn Thr Thr Tyr Arg Arg Val Leu Leu Lys Val Thr Val Asp Met Pro
            2180                2185                2190        
Arg His Ile Val Val Asp Pro Lys Asn Arg Tyr Leu Phe Trp Ala Asp
        2195                2200                2205            
Tyr Gly Gln Arg Pro Lys Ile Glu Arg Ser Phe Leu Asp Cys Thr Asn
    2210                2215                2220                
Arg Thr Val Leu Val Ser Glu Gly Ile Val Thr Pro Arg Gly Leu Ala
2225                2230                2235               2240 
Val Asp Arg Ser Asp Gly Tyr Val Tyr Trp Val Asp Asp Ser Leu Asp
                2245                2250                2255    
Ile Ile Ala Arg Ile Arg Ile Asn Gly Glu Asn Ser Glu Val Ile Arg
            2260                2265                2270        
Tyr Gly Ser Arg Tyr Pro Thr Pro Tyr Gly Ile Thr Val Phe Glu Asn
        2275                2280                2285            
Ser Ile Ile Trp Val Asp Arg Asn Leu Lys Lys Ile Phe Gln Ala Ser
    2290                2295                2300                
Lys Glu Pro Glu Asn Thr Glu Pro Pro Thr Val Ile Arg Asp Asn Ile
2305                2310                2315               2320 
Asn Trp Leu Arg Asp Val Thr Ile Phe Asp Lys Gln Val Gln Pro Arg
                2325                2330                2335    
Ser Pro Ala Glu Val Asn Asn Asn Pro Cys Leu Glu Asn Asn Gly Gly
            2340                2345                2350        
Cys Ser His Leu Cys Phe Ala Leu Pro Gly Leu His Thr Pro Lys Cys
        2355                2360                2365            
Asp Cys Ala Phe Gly Thr Leu Gln Ser Asp Gly Lys Asn Cys Ala Ile
    2370                2375                2380                
Ser Thr Glu Asn Phe Leu Ile Phe Ala Leu Ser Asn Ser Leu Arg Ser
2385                2390                2395               2400 
Leu His Leu Asp Pro Glu Asn His Ser Pro Pro Phe Gln Thr Ile Asn
                2405                2410                2415    
Val Glu Arg Thr Val Met Ser Leu Asp Tyr Asp Ser Val Ser Asp Arg
            2420                2425                2430        
Ile Tyr Phe Thr Gln Asn Leu Ala Ser Gly Val Gly Gln Ile Ser Tyr
        2435                2440                2445            
Ala Thr Leu Ser Ser Gly Ile His Thr Pro Thr Val Ile Ala Ser Gly
    2450                2455                2460                
Ile Gly Thr Ala Asp Gly Ile Ala Phe Asp Trp Ile Thr Arg Arg Ile
2465                2470                2475               2480 
Tyr Tyr Ser Asp Tyr Leu Asn Gln Met Ile Asn Ser Met Ala Glu Asp
                2485                2490                2495    
Gly Ser Asn Arg Thr Val Ile Ala Arg Val Pro Lys Pro Arg Ala Ile
            2500                2505                2510        
Val Leu Asp Pro Cys Gln Gly Tyr Leu Tyr Trp Ala Asp Trp Asp Thr
        2515                2520                2525            
His Ala Lys Ile Glu Arg Ala Thr Leu Gly Gly Asn Phe Arg Val Pro
    2530                2535                2540                
Ile Val Asn Ser Ser Leu Val Met Pro Ser Gly Leu Thr Leu Asp Tyr
2545                2550                2555               2560 
Glu Glu Asp Leu Leu Tyr Trp Val Asp Ala Ser Leu Gln Arg Ile Glu
                2565                2570                2575    
Arg Ser Thr Leu Thr Gly Val Asp Arg Glu Val Ile Val Asn Ala Ala
            2580                2585                2590        
Val His Ala Phe Gly Leu Thr Leu Tyr Gly Gln Tyr Ile Tyr Trp Thr
        2595                2600                2605            
Asp Leu Tyr Thr Gln Arg Ile Tyr Arg Ala Asn Lys Tyr Asp Gly Ser
    2610                2615                2620                
Gly Gln Ile Ala Met Thr Thr Asn Leu Leu Ser Gln Pro Arg Gly Ile
2625                2630                2635               2640 
Asn Thr Val Val Lys Asn Gln Lys Gln Gln Cys Asn Asn Pro Cys Glu
                2645                2650                2655    
Gln Phe Asn Gly Gly Cys Ser His Ile Cys Ala Pro Gly Pro Asn Gly
            2660                2665                2670        
Ala Glu Cys Gln Cys Pro His Glu Gly Asn Trp Tyr Leu Ala Asn Asn
        2675                2680                2685            
Arg Lys His Cys Ile Val Asp Asn Gly Glu Arg Cys Gly Ala Ser Ser
    2690                2695                2700                
Phe Thr Cys Ser Asn Gly Arg Cys Ile Ser Glu Glu Trp Lys Cys Asp
2705                2710                2715               2720 
Asn Asp Asn Asp Cys Gly Asp Gly Ser Asp Glu Met Glu Ser Val Cys
                2725                2730                2735    
Ala Leu His Thr Cys Ser Pro Thr Ala Phe Thr Cys Ala Asn Gly Arg
            2740                2745                2750        
Cys Val Gln Tyr Ser Tyr Arg Cys Asp Tyr Tyr Asn Asp Cys Gly Asp
        2755                2760                2765            
Gly Ser Asp Glu Ala Gly Cys Leu Phe Arg Asp Cys Asn Ala Thr Thr
    2770                2775                2780                
Glu Phe Met Cys Asn Asn Arg Arg Cys Ile Pro Arg Glu Phe Ile Cys
2785                2790                2795               2800 
Asn Gly Val Asp Asn Cys His Asp Asn Asn Thr Ser Asp Glu Lys Asn
                2805                2810                2815    
Cys Pro Asp Arg Thr Cys Gln Ser Gly Tyr Thr Lys Cys His Asn Ser
            2820                2825                2830        
Asn Ile Cys Ile Pro Arg Val Tyr Leu Cys Asp Gly Asp Asn Asp Cys
        2835                2840                2845            
Gly Asp Asn Ser Asp Glu Asn Pro Thr Tyr Cys Thr Thr His Thr Cys
    2850                2855                2860                
Ser Ser Ser Glu Phe Gln Cys Ala Ser Gly Arg Cys Ile Pro Gln His
2865                2870                2875               2880 
Trp Tyr Cys Asp Gln Glu Thr Asp Cys Phe Asp Ala Ser Asp Glu Pro
                2885                2890                2895    
Ala Ser Cys Gly His Ser Glu Arg Thr Cys Leu Ala Asp Glu Phe Lys
            2900                2905                2910        
Cys Asp Gly Gly Arg Cys Ile Pro Ser Glu Trp Ile Cys Asp Gly Asp
        2915                2920                2925            
Asn Asp Cys Gly Asp Met Ser Asp Glu Asp Lys Arg His Gln Cys Gln
    2930                2935                2940                
Asn Gln Asn Cys Ser Asp Ser Glu Phe Leu Cys Val Asn Asp Arg Pro
2945                2950                2955               2960 
Pro Asp Arg Arg Cys Ile Pro Gln Ser Trp Val Cys Asp Gly Asp Val
                2965                2970                2975    
Asp Cys Thr Asp Gly Tyr Asp Glu Asn Gln Asn Cys Thr Arg Arg Thr
            2980                2985                2990        
Cys Ser Glu Asn Glu Phe Thr Cys Gly Tyr Gly Leu Cys Ile Pro Lys
        2995                3000                3005            
Ile Phe Arg Cys Asp Arg His Asn Asp Cys Gly Asp Tyr Ser Asp Glu
    3010                3015                3020                
Arg Gly Cys Leu Tyr Gln Thr Cys Gln Gln Asn Gln Phe Thr Cys Gln
3025                3030                3035               3040 
Asn Gly Arg Cys Ile Ser Lys Thr Phe Val Cys Asp Glu Asp Asn Asp
                3045                3050                3055    
Cys Gly Asp Gly Ser Asp Glu Leu Met His Leu Cys His Thr Pro Glu
            3060                3065                3070        
Pro Thr Cys Pro Pro His Glu Phe Lys Cys Asp Asn Gly Arg Cys Ile
        3075                3080                3085            
Glu Met Met Lys Leu Cys Asn His Leu Asp Asp Cys Leu Asp Asn Ser
    3090                3095                3100                
Asp Glu Lys Gly Cys Gly Ile Asn Glu Cys His Asp Pro Ser Ile Ser
3105                3110                3115               3120 
Gly Cys Asp His Asn Cys Thr Asp Thr Leu Thr Ser Phe Tyr Cys Ser
                3125                3130                3135    
Cys Arg Pro Gly Tyr Lys Leu Met Ser Asp Lys Arg Thr Cys Val Asp
            3140                3145                3150        
Ile Asp Glu Cys Thr Glu Met Pro Phe Val Cys Ser Gln Lys Cys Glu
        3155                3160                3165            
Asn Val Ile Gly Ser Tyr Ile Cys Lys Cys Ala Pro Gly Tyr Leu Arg
    3170                3175                3180                
Glu Pro Asp Gly Lys Thr Cys Arg Gln Asn Ser Asn Ile Glu Pro Tyr
3185                3190                3195               3200 
Leu Ile Phe Ser Asn Arg Tyr Tyr Leu Arg Asn Leu Thr Ile Asp Gly
                3205                3210                3215    
Tyr Phe Tyr Ser Leu Ile Leu Glu Gly Leu Asp Asn Val Val Ala Leu
            3220                3225                3230        
Asp Phe Asp Arg Val Glu Lys Arg Leu Tyr Trp Ile Asp Thr Gln Arg
        3235                3240                3245            
Gln Val Ile Glu Arg Met Phe Leu Asn Lys Thr Asn Lys Glu Thr Ile
    3250                3255                3260                
Ile Asn His Arg Leu Pro Ala Ala Glu Ser Leu Ala Val Asp Trp Val
3265                3270                3275               3280 
Ser Arg Lys Leu Tyr Trp Leu Asp Ala Arg Leu Asp Gly Leu Phe Val
                3285                3290                3295    
Ser Asp Leu Asn Gly Gly His Arg Arg Met Leu Ala Gln His Cys Val
            3300                3305                3310        
Asp Ala Asn Asn Thr Phe Cys Phe Asp Asn Pro Arg Gly Leu Ala Leu
        3315                3320                3325            
His Pro Gln Tyr Gly Tyr Leu Tyr Trp Ala Asp Trp Gly His Arg Ala
    3330                3335                3340                
Tyr Ile Gly Arg Val Gly Met Asp Gly Thr Asn Lys Ser Val Ile Ile
3345                3350                3355               3360 
Ser Thr Lys Leu Glu Trp Pro Asn Gly Ile Thr Ile Asp Tyr Thr Asn
                3365                3370                3375    
Asp Leu Leu Tyr Trp Ala Asp Ala His Leu Gly Tyr Ile Glu Tyr Ser
            3380                3385                3390        
Asp Leu Glu Gly His His Arg His Thr Val Tyr Asp Gly Ala Leu Pro
        3395                3400                3405            
His Pro Phe Ala Ile Thr Ile Phe Glu Asp Thr Ile Tyr Trp Thr Asp
    3410                3415                3420                
Trp Asn Thr Arg Thr Val Glu Lys Gly Asn Lys Tyr Asp Gly Ser Asn
3425                3430                3435               3440 
Arg Gln Thr Leu Val Asn Thr Thr His Arg Pro Phe Asp Ile His Val
                3445                3450                3455    
Tyr His Pro Tyr Arg Gln Pro Ile Val Ser Asn Pro Cys Gly Thr Asn
            3460                3465                3470        
Asn Gly Gly Cys Ser His Leu Cys Leu Ile Lys Pro Gly Gly Lys Gly
        3475                3480                3485            
Phe Thr Cys Glu Cys Pro Asp Asp Phe Arg Thr Leu Gln Leu Ser Gly
    3490                3495                3500                
Ser Thr Tyr Cys Met Pro Met Cys Ser Ser Thr Gln Phe Leu Cys Ala
3505                3510                3515               3520 
Asn Asn Glu Lys Cys Ile Pro Ile Trp Trp Lys Cys Asp Gly Gln Lys
                3525                3530                3535    
Asp Cys Ser Asp Gly Ser Asp Glu Leu Ala Leu Cys Pro Gln Arg Phe
            3540                3545                3550        
Cys Arg Leu Gly Gln Phe Gln Cys Ser Asp Gly Asn Cys Thr Ser Pro
        3555                3560                3565            
Gln Thr Leu Cys Asn Ala His Gln Asn Cys Pro Asp Gly Ser Asp Glu
    3570                3575                3580                
Asp Arg Leu Leu Cys Glu Asn His His Cys Asp Ser Asn Glu Trp Gln
3585                3590                3595               3600 
Cys Ala Asn Lys Arg Cys Ile Pro Glu Ser Trp Gln Cys Asp Thr Phe
                3605                3610                3615    
Asn Asp Cys Glu Asp Asn Ser Asp Glu Asp Ser Ser His Cys Ala Ser
            3620                3625                3630        
Arg Thr Cys Arg Pro Gly Gln Phe Arg Cys Ala Asn Gly Arg Cys Ile
        3635                3640                3645            
Pro Gln Ala Trp Lys Cys Asp Val Asp Asn Asp Cys Gly Asp His Ser
    3650                3655                3660                
Asp Glu Pro Ile Glu Glu Cys Met Ser Ser Ala His Leu Cys Asp Asn
3665                3670                3675               3680 
Phe Thr Glu Phe Ser Cys Lys Thr Asn Tyr Arg Cys Ile Pro Lys Trp
                3685                3690                3695    
Ala Val Cys Asn Gly Val Asp Asp Cys Arg Asp Asn Ser Asp Glu Gln
            3700                3705                3710        
Gly Cys Glu Glu Arg Thr Cys His Pro Val Gly Asp Phe Arg Cys Lys
        3715                3720                3725            
Asn His His Cys Ile Pro Leu Arg Trp Gln Cys Asp Gly Gln Asn Asp
    3730                3735                3740                
Cys Gly Asp Asn Ser Asp Glu Glu Asn Cys Ala Pro Arg Glu Cys Thr
3745                3750                3755               3760 
Glu Ser Glu Phe Arg Cys Val Asn Gln Gln Cys Ile Pro Ser Arg Trp
                3765                3770                3775    
Ile Cys Asp His Tyr Asn Asp Cys Gly Asp Asn Ser Asp Glu Arg Asp
            3780                3785                3790        
Cys Glu Met Arg Thr Cys His Pro Glu Tyr Phe Gln Cys Thr Ser Gly
        3795                3800                3805            
His Cys Val His Ser Glu Leu Lys Cys Asp Gly Ser Ala Asp Cys Leu
    3810                3815                3820                
Asp Ala Ser Asp Glu Ala Asp Cys Pro Thr Arg Phe Pro Asp Gly Ala
3825                3830                3835               3840 
Tyr Cys Gln Ala Thr Met Phe Glu Cys Lys Asn His Val Cys Ile Pro
                3845                3850                3855    
Pro Tyr Trp Lys Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp
            3860                3865                3870        
Glu Glu Leu His Leu Cys Leu Asp Val Pro Cys Asn Ser Pro Asn Arg
        3875                3880                3885            
Phe Arg Cys Asp Asn Asn Arg Cys Ile Tyr Ser His Glu Val Cys Asn
    3890                3895                3900                
Gly Val Asp Asp Cys Gly Asp Gly Thr Asp Glu Thr Glu Glu His Cys
3905                3910                3915               3920 
Arg Lys Pro Thr Pro Lys Pro Cys Thr Glu Tyr Glu Tyr Lys Cys Gly
                3925                3930                3935    
Asn Gly His Cys Ile Pro His Asp Asn Val Cys Asp Asp Ala Asp Asp
            3940                3945                3950        
Cys Gly Asp Trp Ser Asp Glu Leu Gly Cys Asn Lys Gly Lys Glu Arg
        3955                3960                3965            
Thr Cys Ala Glu Asn Ile Cys Glu Gln Asn Cys Thr Gln Leu Asn Glu
    3970                3975                3980                
Gly Gly Phe Ile Cys Ser Cys Thr Ala Gly Phe Glu Thr Asn Val Phe
3985                3990                3995               4000 
Asp Arg Thr Ser Cys Leu Asp Ile Asn Glu Cys Glu Gln Phe Gly Thr
                4005                4010                4015    
Cys Pro Gln His Cys Arg Asn Thr Lys Gly Ser Tyr Glu Cys Val Cys
            4020                4025                4030        
Ala Asp Gly Phe Thr Ser Met Ser Asp Arg Pro Gly Lys Arg Cys Ala
        4035                4040                4045            
Ala Glu Gly Ser Ser Pro Leu Leu Leu Leu Pro Asp Asn Val Arg Ile
    4050                4055                4060                
Arg Lys Tyr Asn Leu Ser Ser Glu Arg Phe Ser Glu Tyr Leu Gln Asp
4065                4070                4075               4080 
Glu Glu Tyr Ile Gln Ala Val Asp Tyr Asp Trp Asp Pro Lys Asp Ile
                4085                4090                4095    
Gly Leu Ser Val Val Tyr Tyr Thr Val Arg Gly Glu Gly Ser Arg Phe
            4100                4105                4110        
Gly Ala Ile Lys Arg Ala Tyr Ile Pro Asn Phe Glu Ser Gly Arg Asn
        4115                4120                4125            
Asn Leu Val Gln Glu Val Asp Leu Lys Leu Lys Tyr Val Met Gln Pro
    4130                4135                4140                
Asp Gly Ile Ala Val Asp Trp Val Gly Arg His Ile Tyr Trp Ser Asp
4145                4150                4155               4160 
Val Lys Asn Lys Arg Ile Glu Val Ala Lys Leu Asp Gly Arg Tyr Arg
                4165                4170                4175    
Lys Trp Leu Ile Ser Thr Asp Leu Asp Gln Pro Ala Ala Ile Ala Val
            4180                4185                4190        
Asn Pro Lys Leu Gly Leu Met Phe Trp Thr Asp Trp Gly Lys Glu Pro
        4195                4200                4205            
Lys Ile Glu Ser Ala Trp Met Asn Gly Glu Asp Arg Asn Ile Leu Val
    4210                4215                4220                
Phe Glu Asp Leu Gly Trp Pro Thr Gly Leu Ser Ile Asp Tyr Leu Asn
4225                4230                4235               4240 
Asn Asp Arg Ile Tyr Trp Ser Asp Phe Lys Glu Asp Val Ile Glu Thr
                4245                4250                4255    
Ile Lys Tyr Asp Gly Thr Asp Arg Arg Val Ile Ala Lys Glu Ala Met
            4260                4265                4270        
Asn Pro Tyr Ser Leu Asp Ile Phe Glu Asp Gln Leu Tyr Trp Ile Ser
        4275                4280                4285            
Lys Glu Lys Gly Glu Val Trp Lys Gln Asn Lys Phe Gly Gln Gly Lys
    4290                4295                4300                
Lys Glu Lys Thr Leu Val Val Asn Pro Trp Leu Thr Gln Val Arg Ile
4305                4310                4315               4320 
Phe His Gln Leu Arg Tyr Asn Lys Ser Val Pro Asn Leu Cys Lys Gln
                4325                4330                4335    
Ile Cys Ser His Leu Cys Leu Leu Arg Pro Gly Gly Tyr Ser Cys Ala
            4340                4345                4350        
Cys Pro Gln Gly Ser Ser Phe Ile Glu Gly Ser Thr Thr Glu Cys Asp
        4355                4360                4365            
Ala Ala Ile Glu Leu Pro Ile Asn Leu Pro Pro Pro Cys Arg Cys Met
    4370                4375                4380                
His Gly Gly Asn Cys Tyr Phe Asp Glu Thr Asp Leu Pro Lys Cys Lys
4385                4390                4395               4400 
Cys Pro Ser Gly Tyr Thr Gly Lys Tyr Cys Glu Met Ala Phe Ser Lys
                4405                4410                4415    
Gly Ile Ser Pro Gly Thr Thr Ala Val Ala Val Leu Leu Thr Ile Leu
            4420                4425                4430        
Leu Ile Val Val Ile Gly Ala Leu Ala Ile Ala Gly Phe Phe His Tyr
        4435                4440                4445            
Arg Arg Thr Gly Ser Leu Leu Pro Ala Leu Pro Lys Leu Pro Ser Leu
    4450                4455                4460                
Ser Ser Leu Val Lys Pro Ser Glu Asn Gly Asn Gly Val Thr Phe Arg
4465                4470                4475               4480 
Ser Gly Ala Asp Leu Asn Met Asp Ile Gly Val Ser Gly Phe Gly Pro
                4485                4490                4495    
Glu Thr Ala Ile Asp Arg Ser Met Ala Met Ser Glu Asp Phe Val Met
            4500                4505                4510        
Glu Met Gly Lys Gln Pro Ile Ile Phe Glu Asn Pro Met Tyr Ser Ala
        4515                4520                4525            
Arg Asp Ser Ala Val Lys Val Val Gln Pro Ile Gln Val Thr Val Ser
    4530                4535                4540                
Glu Asn Val Asp Asn Lys Asn Tyr Gly Ser Pro Ile Asn Pro Ser Glu
4545                4550                4555               4560 
Ile Val Pro Glu Thr Asn Pro Thr Ser Pro Ala Ala Asp Gly Thr Gln
                4565                4570                4575    
Val Thr Lys Trp Asn Leu Phe Lys Arg Lys Ser Lys Gln Thr Thr Asn
            4580                4585                4590        
Phe Glu Asn Pro Ile Tyr Ala Gln Met Glu Asn Glu Gln Lys Glu Ser
        4595                4600                4605            
Val Ala Ala Thr Pro Pro Pro Ser Pro Ser Leu Pro Ala Lys Pro Lys
    4610                4615                4620                
Pro Pro Ser Arg Arg Asp Pro Thr Pro Thr Tyr Ser Ala Thr Glu Asp
4625                4630                4635               4640 
Thr Phe Lys Asp Thr Ala Asn Leu Val Lys Glu Asp Ser Glu Val
                4645                4650                4655


<210> 2
<211> 4660
<212> PRT
<213> Mus Musculus

<400> 2
Met Glu Arg Gly Ala Ala Ala Ala Ala Trp Met Leu Leu Leu Ala Ile
 1               5                  10                  15      
Ala Ala Cys Leu Ala Pro Val Ser Gly Gln Glu Cys Gly Ser Gly Asn
            20                  25                  30          
Phe Arg Cys Asp Asn Gly Tyr Cys Ile Pro Ala Ser Trp Arg Cys Asp
        35                  40                  45              
Gly Thr Arg Asp Cys Leu Asp Asp Thr Asp Glu Ile Gly Cys Pro Pro
    50                  55                  60                  
Arg Ser Cys Gly Ser Gly Phe Phe Leu Cys Pro Ala Glu Gly Thr Cys
65                  70                  75                  80  
Ile Pro Ser Ser Trp Val Cys Asp Gln Asp Lys Asp Cys Ser Asp Gly
                85                  90                  95      
Ala Asp Glu Gln Gln Asn Cys Pro Gly Thr Thr Cys Ser Ser Gln Gln
            100                 105                 110         
Leu Thr Cys Ser Asn Gly Gln Cys Val Pro Ile Glu Tyr Arg Cys Asp
        115                 120                 125             
His Val Ser Asp Cys Pro Asp Gly Ser Asp Glu Arg Asn Cys Tyr Tyr
    130                 135                 140                 
Pro Thr Cys Asp Gln Leu Thr Cys Ala Asn Gly Ala Cys Tyr Asn Thr
145                 150                 155                 160 
Ser Gln Lys Cys Asp His Lys Val Asp Cys Arg Asp Ser Ser Asp Glu
                165                 170                 175     
Ala Asn Cys Thr Thr Leu Cys Ser Gln Lys Glu Phe Gln Cys Gly Ser
            180                 185                 190         
Gly Glu Cys Ile Leu Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys
        195                 200                 205             
Glu Asp Asn Ser Asp Glu His Asn Cys Asn Tyr Asp Thr Cys Gly Gly
    210                 215                 220                 
His Gln Phe Thr Cys Ser Asn Gly Gln Cys Ile Asn Gln Asn Trp Val
225                 230                 235                 240 
Cys Asp Gly Asp Asp Asp Cys Gln Asp Ser Gly Asp Glu Asp Gly Cys
                245                 250                 255     
Glu Ser Asn Gln Arg His His Thr Cys Tyr Pro Arg Glu Trp Ala Cys
            260                 265                 270         
Pro Gly Ser Gly Arg Cys Ile Ser Met Asp Lys Val Cys Asp Gly Val
        275                 280                 285             
Pro Asp Cys Pro Glu Gly Glu Asp Glu Asn Asn Ala Thr Ser Gly Arg
    290                 295                 300                 
Tyr Cys Gly Thr Gly Leu Cys Ser Ile Leu Asn Cys Glu Tyr Gln Cys
305                 310                 315                 320 
His Gln Thr Pro Tyr Gly Gly Glu Cys Phe Cys Pro Pro Gly His Ile
                325                 330                 335     
Ile Asn Ser Asn Asp Ser Arg Thr Cys Ile Asp Phe Asp Asp Cys Gln
            340                 345                 350         
Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Gln Gly Arg His
        355                 360                 365             
Gln Cys Leu Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln His Cys
    370                 375                 380                 
Lys Ser Asn Asp Ser Phe Ser Ala Ala Ser Ile Ile Phe Ser Asn Gly
385                 390                 395                 400 
Arg Asp Leu Leu Val Gly Asp Leu His Gly Arg Asn Phe Arg Ile Leu
                405                 410                 415     
Ala Glu Ser Lys Asn Arg Gly Ile Val Met Gly Val Asp Phe His Tyr
            420                 425                 430         
Gln Lys His Arg Val Phe Trp Thr Asp Pro Met Gln Ala Lys Val Phe
        435                 440                 445             
Ser Thr Asp Ile Asn Gly Leu Asn Thr Gln Glu Ile Leu Asn Val Ser
    450                 455                 460                 
Ile Asp Ala Pro Glu Asn Leu Ala Val Asp Trp Ile Asn Asn Lys Leu
465                 470                 475                 480 
Tyr Leu Val Glu Thr Arg Val Asn Arg Ile Asp Val Val Asn Leu Glu
                485                 490                 495     
Gly Asn Gln Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro Arg
            500                 505                 510         
Gly Ile Ala Leu Asp Pro Thr Val Gly Tyr Leu Phe Phe Ser Asp Trp
        515                 520                 525             
Gly Ser Leu Ser Gly Gln Pro Lys Val Glu Arg Ala Phe Met Asp Gly
    530                 535                 540                 
Ser Asn Arg Lys Asp Leu Val Thr Thr Lys Leu Gly Trp Pro Ala Gly
545                 550                 555                 560 
Ile Thr Leu Asp Leu Val Ser Lys Arg Val Tyr Trp Val Asp Ser Arg
                565                 570                 575     
Tyr Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile Gln Arg Lys Thr
            580                 585                 590         
Val Ala Arg Gly Gly Ser Leu Val Pro His Pro Phe Gly Ile Ser Leu
        595                 600                 605             
Phe Glu Glu His Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val Met
    610                 615                 620                 
Lys Ala Asn Lys Phe Thr Asp Thr Asn Pro Gln Val Tyr His Gln Ser
625                 630                 635                 640 
Ser Leu Thr Pro Phe Gly Val Thr Val Tyr His Ala Leu Arg Gln Pro
                645                 650                 655     
Asn Ala Thr Asn Pro Cys Gly Asn Asn Asn Gly Gly Cys Ala Gln Ile
            660                 665                 670         
Cys Val Leu Ser His Arg Thr Asp Asn Gly Gly Leu Gly Tyr Arg Cys
        675                 680                 685             
Lys Cys Glu Phe Gly Phe Glu Leu Asp Ala Asp Glu His His Cys Val
    690                 695                 700                 
Ala Val Lys Asn Phe Leu Leu Phe Ser Ser Gln Thr Ala Val Arg Gly
705                 710                 715                 720 
Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met Val Pro Val Thr
                725                 730                 735     
Gly Ser Pro Ser Phe Phe Val Gly Ile Asp Phe Asp Ala Gln His Ser
            740                 745                 750         
Thr Ile Phe Tyr Ser Asp Leu Ser Lys Asn Ile Ile Tyr Gln Gln Lys
        755                 760                 765             
Ile Asp Gly Thr Gly Lys Glu Val Ile Thr Ala Asn Arg Leu Gln Asn
    770                 775                 780                 
Val Glu Cys Leu Ser Phe Asp Trp Ile Ser Arg Asn Leu Tyr Trp Thr
785                 790                 795                 800 
Asp Gly Gly Ser Lys Ser Val Thr Val Met Lys Leu Ala Asp Lys Ser
                805                 810                 815     
Arg Arg Gln Ile Ile Ser Asn Leu Asn Asn Pro Arg Ser Ile Val Val
            820                 825                 830         
His Pro Ala Ala Gly Tyr Met Phe Leu Ser Asp Trp Phe Arg Pro Ala
        835                 840                 845             
Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu Met Pro Ile Val
    850                 855                 860                 
Asn Thr Ser Leu Gly Trp Pro Asn Gly Leu Ala Ile Asp Trp Ser Thr
865                 870                 875                 880 
Ser Arg Leu Tyr Trp Val Asp Ala Phe Phe Asp Lys Ile Glu His Ser
                885                 890                 895     
Asn Leu Asp Gly Leu Asp Arg Lys Arg Leu Gly His Val Asp Gln Met
            900                 905                 910         
Thr His Pro Phe Gly Leu Thr Val Phe Lys Asp Asn Val Phe Leu Thr
        915                 920                 925             
Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg Lys Ser Asp Gly Gly
    930                 935                 940                 
Asp Met Thr Val Val Arg Arg Gly Ile Ser Ser Ile Met His Val Lys
945                 950                 955                 960 
Ala Tyr Asp Ala Asp Leu Gln Thr Gly Thr Asn Tyr Cys Ser Gln Thr
                965                 970                 975     
Thr His Pro Asn Gly Asp Cys Ser His Phe Cys Phe Pro Val Pro Asn
            980                 985                 990         
Phe Gln Arg Val Cys Gly Cys Pro Tyr Gly Met Lys Leu Gln Arg Asp
        995                 1000                1005            
Gln Met Thr Cys Glu Gly Asp Pro Ala Arg Glu Pro Pro Thr Gln Gln
    1010                1015                1020                
Cys Gly Ser Ser Ser Phe Pro Cys Asn Asn Gly Lys Cys Val Pro Ser
1025                1030                1035               1040 
Ile Phe Arg Cys Asp Gly Val Asp Asp Cys His Asp Asn Ser Asp Glu
                1045                1050                1055    
His Gln Cys Gly Ala Leu Asn Asn Thr Cys Ser Ser Ser Ala Phe Thr
            1060                1065                1070        
Cys Val His Gly Gly Gln Cys Ile Pro Gly Gln Trp Arg Cys Asp Lys
        1075                1080                1085            
Gln Asn Asp Cys Leu Asp Gly Ser Asp Glu Gln Asn Cys Pro Thr Arg
    1090                1095                1100                
Ser Pro Ser Ser Thr Cys Pro Pro Thr Ser Phe Thr Cys Asp Asn His
1105                1110                1115               1120 
Met Cys Ile Pro Lys Glu Trp Val Cys Asp Thr Asp Asn Asp Cys Ser
                1125                1130                1135    
Asp Gly Ser Asp Glu Lys Asn Cys Gln Ala Ser Gly Thr Cys His Pro
            1140                1145                1150        
Thr Gln Phe Arg Cys Pro Asp His Arg Cys Ile Ser Pro Leu Tyr Val
        1155                1160                1165            
Cys Asp Gly Asp Lys Asp Cys Val Asp Gly Ser Asp Glu Ala Gly Cys
    1170                1175                1180                
Val Leu Asn Cys Thr Ser Ser Gln Phe Lys Cys Ala Asp Gly Ser Ser
1185                1190                1195               1200 
Cys Ile Asn Ser Arg Tyr Arg Cys Asp Gly Val Tyr Asp Cys Lys Asp
                1205                1210                1215    
Asn Ser Asp Glu Ala Gly Cys Pro Thr Arg Pro Pro Gly Met Cys His
            1220                1225                1230        
Pro Asp Glu Phe Gln Cys Gln Gly Asp Gly Thr Cys Ile Pro Asn Thr
        1235                1240                1245            
Trp Glu Cys Asp Gly His Pro Asp Cys Ile Gln Gly Ser Asp Glu His
    1250                1255                1260                
Asn Gly Cys Val Pro Lys Thr Cys Ser Pro Ser His Phe Leu Cys Asp
1265                1270                1275               1280 
Asn Gly Asn Cys Ile Tyr Asn Ser Trp Val Cys Asp Gly Asp Asn Asp
                1285                1290                1295    
Cys Arg Asp Met Ser Asp Glu Lys Asp Cys Pro Thr Gln Pro Phe His
            1300                1305                1310        
Cys Pro Ser Ser Gln Trp Gln Cys Pro Gly Tyr Ser Ile Cys Val Asn
        1315                1320                1325            
Leu Ser Ala Leu Cys Asp Gly Val Phe Asp Cys Pro Asn Gly Thr Asp
    1330                1335                1340                
Glu Ser Pro Leu Cys Asn Gln Asp Ser Cys Leu His Phe Asn Gly Gly
1345                1350                1355               1360 
Cys Thr His Arg Cys Ile Gln Gly Pro Phe Gly Ala Thr Cys Val Cys
                1365                1370                1375    
Pro Ile Gly Tyr Gln Leu Ala Asn Asp Thr Lys Thr Cys Glu Asp Val
            1380                1385                1390        
Asn Glu Cys Asp Ile Pro Gly Phe Cys Ser Gln His Cys Val Asn Met
        1395                1400                1405            
Arg Gly Ser Phe Arg Cys Ala Cys Asp Pro Glu Tyr Thr Leu Glu Ser
    1410                1415                1420                
Asp Gly Arg Thr Cys Lys Val Thr Ala Ser Glu Asn Leu Leu Leu Val
1425                1430                1435               1440 
Val Ala Ser Arg Asp Lys Ile Ile Met Asp Asn Ile Thr Ala His Thr
                1445                1450                1455    
His Asn Ile Tyr Ser Leu Val Gln Asp Val Ser Phe Val Val Ala Leu
            1460                1465                1470        
Asp Phe Asp Ser Val Thr Gly Arg Val Phe Trp Ser Asp Leu Leu Glu
        1475                1480                1485            
Gly Lys Thr Trp Ser Ala Phe Gln Asn Gly Thr Asp Lys Arg Val Val
    1490                1495                1500                
His Asp Ser Gly Leu Ser Leu Thr Glu Met Ile Ala Val Asp Trp Ile
1505                1510                1515               1520 
Gly Arg Asn Ile Tyr Trp Thr Asp Tyr Thr Leu Glu Thr Ile Glu Val
                1525                1530                1535    
Ser Lys Ile Asp Gly Ser His Arg Thr Val Leu Ile Ser Lys Asn Val
            1540                1545                1550        
Thr Lys Pro Arg Gly Leu Ala Leu Asp Pro Arg Met Gly Asp Asn Val
        1555                1560                1565            
Met Phe Trp Ser Asp Trp Gly His His Pro Arg Ile Glu Arg Ala Ser
    1570                1575                1580                
Met Asp Gly Thr Met Arg Thr Val Ile Val Gln Glu Lys Ile Tyr Trp
1585                1590                1595               1600 
Pro Cys Gly Leu Ser Ile Asp Tyr Pro Asn Arg Leu Ile Tyr Phe Met
                1605                1610                1615    
Asp Ala Tyr Leu Asp Tyr Ile Glu Phe Cys Asp Tyr Asp Gly Gln Asn
            1620                1625                1630        
Arg Arg Gln Val Ile Ala Ser Asp Leu Val Leu His His Pro His Ala
        1635                1640                1645            
Leu Thr Leu Phe Glu Asp Ser Val Phe Trp Thr Asp Arg Gly Thr His
    1650                1655                1660                
Gln Val Met Gln Ala Asn Lys Trp His Gly Arg Asn Gln Ser Val Val
1665                1670                1675               1680 
Met Tyr Ser Val Pro Gln Pro Leu Gly Ile Ile Ala Ile His Pro Ser
                1685                1690                1695    
Arg Gln Pro Ser Ser Pro Asn Pro Cys Ala Ser Ala Thr Cys Ser His
            1700                1705                1710        
Leu Cys Leu Leu Ser Ala Gln Glu Pro Arg His Tyr Ser Cys Ala Cys
        1715                1720                1725            
Pro Ser Gly Trp Asn Leu Ser Asp Asp Ser Val Asn Cys Val Arg Gly
    1730                1735                1740                
Asp Gln Pro Phe Leu Ile Ser Val Arg Glu Asn Val Ile Phe Gly Ile
1745                1750                1755               1760 
Ser Leu Asp Pro Glu Val Lys Ser Asn Asp Ala Met Val Pro Ile Ser
                1765                1770                1775    
Gly Ile Gln His Gly Tyr Asp Val Glu Phe Asp Asp Ser Glu Gln Phe
            1780                1785                1790        
Ile Tyr Trp Val Glu Asn Pro Gly Glu Ile His Arg Val Lys Thr Asp
        1795                1800                1805            
Gly Ser Asn Arg Thr Ala Phe Ala Pro Leu Ser Leu Leu Gly Ser Ser
    1810                1815                1820                
Leu Gly Leu Ala Leu Asp Trp Val Ser Arg Asn Ile Tyr Tyr Thr Thr
1825                1830                1835               1840 
Pro Ala Ser Arg Ser Ile Glu Val Leu Thr Leu Arg Gly Asp Thr Arg
                1845                1850                1855    
Tyr Gly Lys Thr Leu Ile Thr Asn Asp Gly Thr Pro Leu Gly Val Gly
            1860                1865                1870        
Phe Pro Val Gly Ile Ala Val Asp Pro Ala Arg Gly Lys Leu Tyr Trp
        1875                1880                1885            
Ser Asp His Gly Thr Asp Ser Gly Val Pro Ala Lys Ile Ala Ser Ala
    1890                1895                1900                
Asn Met Asp Gly Thr Ser Leu Lys Ile Leu Phe Thr Gly Asn Met Glu
1905                1910                1915               1920 
His Leu Glu Val Val Thr Leu Asp Ile Gln Glu Gln Lys Leu Tyr Trp
                1925                1930                1935    
Ala Val Thr Ser Arg Gly Val Ile Glu Arg Gly Asn Val Asp Gly Thr
            1940                1945                1950        
Glu Arg Met Ile Leu Val His His Leu Ala His Pro Trp Gly Leu Val
        1955                1960                1965            
Val His Gly Ser Phe Leu Tyr Tyr Ser Asp Glu Gln Tyr Glu Val Ile
    1970                1975                1980                
Glu Arg Val Asp Lys Ser Ser Gly Ser Asn Lys Val Val Phe Arg Asp
1985                1990                1995               2000 
Asn Ile Pro Tyr Leu Arg Gly Leu Arg Val Tyr His His Arg Asn Ala
                2005                2010                2015    
Ala Asp Ser Ser Asn Gly Cys Ser Asn Asn Pro Asn Ala Cys Gln Gln
            2020                2025                2030        
Ile Cys Leu Pro Val Pro Gly Gly Met Phe Ser Cys Ala Cys Ala Ser
        2035                2040                2045            
Gly Phe Lys Leu Ser Pro Asp Gly Arg Ser Cys Ser Pro Tyr Asn Ser
    2050                2055                2060                
Phe Ile Val Val Ser Met Leu Pro Ala Val Arg Gly Phe Ser Leu Glu
2065                2070                2075               2080 
Leu Ser Asp His Ser Glu Ala Met Val Pro Val Ala Gly Gln Gly Arg
                2085                2090                2095    
Asn Val Leu His Ala Asp Val Asp Val Ala Asn Gly Phe Ile Tyr Trp
            2100                2105                2110        
Cys Asp Phe Ser Ser Ser Val Arg Ser Ser Asn Gly Ile Arg Arg Ile
        2115                2120                2125            
Lys Pro Asn Gly Ser Asn Phe Thr Asn Ile Val Thr Tyr Gly Ile Gly
    2130                2135                2140                
Ala Asn Gly Ile Arg Gly Val Ala Val Asp Trp Val Ala Gly Asn Leu
2145                2150                2155               2160 
Tyr Phe Thr Asn Ala Phe Val Tyr Glu Thr Leu Ile Glu Val Ile Arg
                2165                2170                2175    
Ile Asn Thr Thr Tyr Arg Arg Val Leu Leu Lys Val Ser Val Asp Met
            2180                2185                2190        
Pro Arg His Ile Val Val Asp Pro Lys His Arg Tyr Leu Phe Trp Ala
        2195                2200                2205            
Asp Tyr Gly Gln Lys Pro Lys Ile Glu Arg Ser Phe Leu Asp Cys Thr
    2210                2215                2220                
Asn Arg Thr Val Leu Val Ser Glu Gly Ile Val Thr Pro Arg Gly Leu
2225                2230                2235               2240 
Ala Val Asp His Asp Thr Gly Tyr Ile Tyr Trp Val Asp Asp Ser Leu
                2245                2250                2255    
Asp Ile Ile Ala Arg Ile His Arg Asp Gly Gly Glu Ser Gln Val Val
            2260                2265                2270        
Arg Tyr Gly Ser Arg Tyr Pro Thr Pro Tyr Gly Ile Thr Val Phe Gly
        2275                2280                2285            
Glu Ser Ile Ile Trp Val Asp Arg Asn Leu Arg Lys Val Phe Gln Ala
    2290                2295                2300                
Ser Lys Gln Pro Gly Asn Thr Asp Pro Pro Thr Val Ile Arg Asp Ser
2305                2310                2315               2320 
Ile Asn Leu Leu Arg Asp Val Thr Ile Phe Asp Glu His Val Gln Pro
                2325                2330                2335    
Leu Ser Pro Ala Glu Leu Asn Asn Asn Pro Cys Leu Gln Ser Asn Gly
            2340                2345                2350        
Gly Cys Ser His Phe Cys Phe Ala Leu Pro Glu Leu Pro Thr Pro Lys
        2355                2360                2365            
Cys Gly Cys Ala Phe Gly Thr Leu Glu Asp Asp Gly Lys Asn Cys Ala
    2370                2375                2380                
Thr Ser Arg Glu Asp Phe Leu Ile Tyr Ser Leu Asn Asn Ser Leu Arg
2385                2390                2395               2400 
Ser Leu His Phe Asp Pro Gln Asp His Asn Leu Pro Phe Gln Ala Ile
                2405                2410                2415    
Ser Val Glu Gly Met Ala Ile Ala Leu Asp Tyr Asp Arg Arg Asn Asn
            2420                2425                2430        
Arg Ile Phe Phe Thr Gln Lys Leu Asn Pro Ile Arg Gly Gln Ile Ser
        2435                2440                2445            
Tyr Val Asn Leu Tyr Ser Gly Ala Ser Ser Pro Thr Ile Leu Leu Ser
    2450                2455                2460                
Asn Ile Gly Val Thr Asp Gly Ile Ala Phe Asp Trp Ile Asn Arg Arg
2465                2470                2475               2480 
Ile Tyr Tyr Ser Asp Phe Ser Asn Gln Thr Ile Asn Ser Met Ala Glu
                2485                2490                2495    
Asp Gly Ser Asn Arg Ala Val Ile Ala Arg Val Ser Lys Pro Arg Ala
            2500                2505                2510        
Ile Val Leu Asp Pro Cys Arg Gly Tyr Met Tyr Trp Thr Asp Trp Gly
        2515                2520                2525            
Thr Asn Ala Lys Ile Glu Arg Ala Thr Leu Gly Gly Asn Phe Arg Val
    2530                2535                2540                
Pro Ile Val Asn Thr Ser Leu Val Trp Pro Asn Gly Leu Thr Leu Asp
2545                2550                2555               2560 
Leu Glu Thr Asp Leu Leu Tyr Trp Ala Asp Ala Ser Leu Gln Lys Ile
                2565                2570                2575    
Glu Arg Ser Thr Leu Thr Gly Ser Asn Arg Glu Val Val Ile Ser Thr
            2580                2585                2590        
Ala Phe His Ser Phe Gly Leu Thr Val Tyr Gly Gln Tyr Ile Tyr Trp
        2595                2600                2605            
Thr Asp Phe Tyr Thr Lys Lys Ile Tyr Arg Ala Asn Lys Tyr Asp Gly
    2610                2615                2620                
Ser Asp Leu Ile Ala Met Thr Thr Arg Leu Pro Thr Gln Pro Ser Gly
2625                2630                2635               2640 
Ile Ser Thr Val Val Lys Thr Gln Gln Gln Gln Cys Ser Asn Pro Cys
                2645                2650                2655    
Asp Gln Phe Asn Gly Gly Cys Ser His Ile Cys Ala Pro Gly Pro Asn
            2660                2665                2670        
Gly Ala Glu Cys Gln Cys Pro His Glu Gly Ser Trp Tyr Leu Ala Asn
        2675                2680                2685            
Asp Asn Lys Tyr Cys Val Val Asp Thr Gly Ala Arg Cys Asn Gln Phe
    2690                2695                2700                
Gln Phe Thr Cys Leu Asn Gly Arg Cys Ile Ser Gln Asp Trp Lys Cys
2705                2710                2715               2720 
Asp Asn Asp Asn Asp Cys Gly Asp Gly Ser Asp Glu Leu Pro Thr Val
                2725                2730                2735    
Cys Ala Phe His Thr Cys Arg Ser Thr Ala Phe Thr Cys Ala Asn Gly
            2740                2745                2750        
Arg Cys Val Pro Tyr His Tyr Arg Cys Asp Phe Tyr Asn Asp Cys Gly
        2755                2760                2765            
Asp Asn Ser Asp Glu Ala Gly Cys Leu Phe Arg Ser Cys Asn Ser Thr
    2770                2775                2780                
Thr Glu Phe Thr Cys Ser Asn Gly Arg Cys Ile Pro Leu Ser Tyr Val
2785                2790                2795               2800 
Cys Asn Gly Ile Asn Asn Cys His Asp Asn Asp Thr Ser Asp Glu Lys
                2805                2810                2815    
Asn Cys Pro Pro Ile Thr Cys Gln Pro Asp Phe Ala Lys Cys Gln Thr
            2820                2825                2830        
Thr Asn Ile Cys Val Pro Arg Ala Phe Leu Cys Asp Gly Asp Asn Asp
        2835                2840                2845            
Cys Gly Asp Gly Ser Asp Glu Asn Pro Ile Tyr Cys Ala Ser His Thr
    2850                2855                2860                
Cys Arg Ser Asn Glu Phe Gln Cys Val Ser Pro His Arg Cys Ile Pro
2865                2870                2875               2880 
Ser Tyr Trp Phe Cys Asp Gly Glu Ala Asp Cys Val Asp Ser Ser Asp
                2885                2890                2895    
Glu Pro Asp Thr Cys Gly His Ser Leu Asn Ser Cys Ser Ala Asn Gln
            2900                2905                2910        
Phe His Cys Asp Asn Gly Arg Cys Ile Ser Ser Ser Trp Val Cys Asp
        2915                2920                2925            
Gly Asp Asn Asp Cys Gly Asp Met Ser Asp Glu Asp Gln Arg His His
    2930                2935                2940                
Cys Glu Leu Gln Asn Cys Ser Ser Thr Glu Phe Thr Cys Ile Asn Ser
2945                2950                2955               2960 
Arg Pro Pro Asn Arg Arg Cys Ile Pro Gln His Trp Val Cys Asp Gly
                2965                2970                2975    
Asp Ala Asp Cys Ala Asp Ala Leu Asp Glu Leu Gln Asn Cys Thr Met
            2980                2985                2990        
Arg Ala Cys Ser Thr Gly Glu Phe Ser Cys Ala Asn Gly Arg Cys Ile
        2995                3000                3005            
Arg Gln Ser Phe Arg Cys Asp Arg Arg Asn Asp Cys Gly Asp Tyr Ser
    3010                3015                3020                
Asp Glu Arg Gly Cys Ser Tyr Pro Pro Cys Arg Asp Asp Gln Phe Thr
3025                3030                3035               3040 
Cys Gln Asn Gly Gln Cys Ile Thr Lys Leu Tyr Val Cys Asp Glu Asp
                3045                3050                3055    
Asn Asp Cys Gly Asp Gly Ser Asp Glu Gln Glu His Leu Cys His Thr
            3060                3065                3070        
Pro Glu Pro Thr Cys Pro Pro His Gln Phe Arg Cys Asp Asn Gly His
        3075                3080                3085            
Cys Ile Glu Met Gly Thr Val Cys Asn His Val Asp Asp Cys Ser Asp
    3090                3095                3100                
Asn Ser Asp Glu Lys Gly Cys Gly Ile Asn Glu Cys Gln Asp Ser Ser
3105                3110                3115               3120 
Ile Ser His Cys Asp His Asn Cys Thr Asp Thr Ile Thr Ser Phe Tyr
                3125                3130                3135    
Cys Ser Cys Leu Pro Gly Tyr Lys Leu Met Ser Asp Lys Arg Thr Cys
            3140                3145                3150        
Val Asp Ile Asp Glu Cys Lys Glu Thr Pro Gln Leu Cys Ser Gln Lys
        3155                3160                3165            
Cys Glu Asn Val Ile Gly Ser Tyr Ile Cys Lys Cys Ala Pro Gly Tyr
    3170                3175                3180                
Ile Arg Glu Pro Asp Gly Lys Ser Cys Arg Gln Asn Ser Asn Ile Glu
3185                3190                3195               3200 
Pro Tyr Leu Val Phe Ser Asn Arg Tyr Tyr Ile Arg Asn Leu Thr Ile
                3205                3210                3215    
Asp Gly Thr Ser Tyr Ser Leu Ile Leu Gln Gly Leu Gly Asn Val Val
            3220                3225                3230        
Ala Leu Asp Phe Asp Arg Val Glu Glu Arg Leu Tyr Trp Ile Asp Ala
        3235                3240                3245            
Glu Lys Gln Ile Ile Glu Arg Met Phe Leu Asn Lys Thr Asn Gln Glu
    3250                3255                3260                
Thr Ile Ile Ser His Arg Leu Arg Arg Ala Glu Ser Leu Ala Val Asp
3265                3270                3275               3280 
Trp Val Ser Arg Lys Leu Tyr Trp Leu Asp Ala Ile Leu Asp Cys Leu
                3285                3290                3295    
Phe Val Ser Asp Leu Glu Gly Arg Gln Arg Lys Met Leu Ala Gln His
            3300                3305                3310        
Cys Val Asp Ala Asn Asn Thr Phe Cys Phe Glu Asn Pro Arg Gly Ile
        3315                3320                3325            
Val Leu His Pro Gln Arg Gly Tyr Val Tyr Trp Ala Asp Trp Gly Asp
    3330                3335                3340                
His Ala Tyr Ile Ala Arg Ile Gly Met Asp Gly Thr Asn Lys Thr Val
3345                3350                3355               3360 
Ile Ile Ser Thr Lys Ile Glu Trp Pro Asn Ala Ile Thr Ile Asp Tyr
                3365                3370                3375    
Thr Asn Asp Leu Leu Tyr Trp Ala Asp Ala His Leu Gly Tyr Ile Glu
            3380                3385                3390        
Phe Ser Asp Leu Glu Gly His His Arg His Thr Val Tyr Asp Gly Thr
        3395                3400                3405            
Leu Pro His Pro Phe Ala Leu Thr Ile Phe Glu Asp Thr Val Phe Trp
    3410                3415                3420                
Thr Asp Trp Asn Thr Arg Thr Val Glu Lys Gly Asn Lys Tyr Asp Gly
3425                3430                3435               3440 
Ser Gly Arg Val Val Leu Val Asn Thr Thr His Lys Pro Phe Asp Ile
                3445                3450                3455    
His Val Leu His Pro Tyr Arg Gln Pro Ile Met Ser Asn Pro Cys Ala
            3460                3465                3470        
Thr Asn Asn Gly Gly Cys Ser His Leu Cys Leu Ile Lys Ala Gly Gly
        3475                3480                3485            
Arg Gly Phe Thr Cys Glu Cys Pro Asp Asp Phe Gln Thr Val Gln Leu
    3490                3495                3500                
Arg Asp Arg Thr Leu Cys Met Pro Met Cys Ser Ser Thr Gln Phe Leu
3505                3510                3515               3520 
Cys Gly Asn Asn Glu Lys Cys Ile Pro Ile Trp Trp Lys Cys Asp Gly
                3525                3530                3535    
Gln Lys Asp Cys Ser Asp Gly Ser Asp Glu Ser Asp Leu Cys Pro His
            3540                3545                3550        
Arg Phe Cys Arg Leu Gly Gln Phe Gln Cys Arg Asp Gly Asn Cys Thr
        3555                3560                3565            
Ser Pro Gln Ala Leu Cys Asn Ala Arg Gln Asp Cys Ala Asp Gly Ser
    3570                3575                3580                
Asp Glu Asp Arg Val Leu Cys Glu His His Arg Cys Glu Ala Asn Glu
3585                3590                3595               3600 
Trp Gln Cys Ala Asn Lys Arg Cys Ile Pro Glu Tyr Trp Gln Cys Asp
                3605                3610                3615    
Ser Val Asp Asp Cys Leu Asp Asn Ser Asp Glu Asp Pro Ser His Cys
            3620                3625                3630        
Ala Ser Arg Thr Cys Arg Pro Gly Gln Phe Lys Cys Asn Asn Gly Arg
        3635                3640                3645            
Cys Ile Pro Gln Ser Trp Lys Cys Asp Val Asp Asn Asp Cys Gly Asp
    3650                3655                3660                
Tyr Ser Asp Glu Pro Ile His Glu Cys Met Thr Ala Ala Tyr Asn Cys
3665                3670                3675               3680 
Asp Asn His Thr Glu Phe Ser Cys Lys Thr Asn Tyr Arg Cys Ile Pro
                3685                3690                3695    
Gln Trp Ala Val Cys Asn Gly Phe Asp Asp Cys Arg Asp Asn Ser Asp
            3700                3705                3710        
Glu Gln Gly Cys Glu Ser Val Pro Cys His Pro Ser Gly Asp Phe Arg
        3715                3720                3725            
Cys Gly Asn His His Cys Ile Pro Leu Arg Trp Lys Cys Asp Gly Ile
    3730                3735                3740                
Asp Asp Cys Gly Asp Asn Ser Asp Glu Glu Ser Cys Val Pro Arg Glu
3745                3750                3755               3760 
Cys Thr Glu Ser Glu Phe Arg Cys Ala Asp Gln Gln Cys Ile Pro Ser
                3765                3770                3775    
Arg Trp Val Cys Asp Gln Glu Asn Asp Cys Gly Asp Asn Ser Asp Glu
            3780                3785                3790        
Arg Asp Cys Glu Met Lys Thr Cys His Pro Glu His Phe Gln Cys Thr
        3795                3800                3805            
Ser Gly His Cys Val Pro Lys Ala Leu Ala Cys Asp Gly Arg Ala Asp
    3810                3815                3820                
Cys Leu Asp Ala Ser Asp Glu Ser Ala Cys Pro Thr Arg Phe Pro Asn
3825                3830                3835               3840 
Gly Thr Tyr Cys Pro Ala Ala Met Phe Glu Cys Lys Asn His Val Cys
                3845                3850                3855    
Ile Gln Ser Phe Trp Ile Cys Asp Gly Glu Asn Asp Cys Val Asp Gly
            3860                3865                3870        
Ser Asp Glu Glu Ile His Leu Cys Phe Asn Val Pro Cys Glu Ser Pro
        3875                3880                3885            
Gln Arg Phe Arg Cys Asp Asn Ser Arg Cys Ile Tyr Gly His Gln Leu
    3890                3895                3900                
Cys Asn Gly Val Asp Asp Cys Gly Asp Gly Ser Asp Glu Lys Glu Glu
3905                3910                3915               3920 
His Cys Arg Lys Pro Thr His Lys Pro Cys Thr Asp Thr Glu Tyr Lys
                3925                3930                3935    
Cys Ser Asn Gly Asn Cys Val Ser Gln His Tyr Val Cys Asp Asn Val
            3940                3945                3950        
Asp Asp Cys Gly Asp Leu Ser Asp Glu Thr Gly Cys Asn Leu Gly Glu
        3955                3960                3965            
Asn Arg Thr Cys Ala Glu Lys Ile Cys Glu Gln Asn Cys Thr Gln Leu
    3970                3975                3980                
Ser Asn Gly Gly Phe Ile Cys Ser Cys Arg Pro Gly Phe Lys Pro Ser
3985                3990                3995               4000 
Thr Leu Asp Lys Asn Ser Cys Gln Asp Ile Asn Glu Cys Glu Glu Phe
                4005                4010                4015    
Gly Ile Cys Pro Gln Ser Cys Arg Asn Ser Lys Gly Ser Tyr Glu Cys
            4020                4025                4030        
Phe Cys Val Asp Gly Phe Lys Ser Met Ser Thr His Tyr Gly Glu Arg
        4035                4040                4045            
Cys Ala Ala Asp Gly Ser Pro Pro Leu Leu Leu Leu Pro Glu Asn Val
    4050                4055                4060                
Arg Ile Arg Lys Tyr Asn Ile Ser Ser Glu Lys Phe Ser Glu Tyr Leu
4065                4070                4075               4080 
Glu Glu Glu Glu His Ile Gln Ala Ile Asp Tyr Asp Trp Asp Pro Glu
                4085                4090                4095    
Gly Ile Gly Leu Ser Val Val Tyr Tyr Thr Val Leu Ser Gln Gly Ser
            4100                4105                4110        
Gln Phe Gly Ala Ile Lys Arg Ala Tyr Leu Pro Asp Phe Glu Ser Gly
        4115                4120                4125            
Ser Asn Asn Pro Val Arg Glu Val Asp Leu Gly Leu Lys Tyr Leu Met
    4130                4135                4140                
Gln Pro Asp Gly Leu Ala Val Asp Trp Val Gly Arg His Ile Tyr Trp
4145                4150                4155               4160 
Ser Asp Ala Lys Ser Gln Arg Ile Glu Val Ala Thr Leu Asp Gly Arg
                4165                4170                4175    
Tyr Arg Lys Trp Leu Ile Thr Thr Gln Leu Asp Gln Pro Ala Ala Ile
            4180                4185                4190        
Ala Val Asn Pro Lys Leu Gly Leu Met Phe Trp Thr Asp Gln Gly Lys
        4195                4200                4205            
Gln Pro Lys Ile Glu Ser Ala Trp Met Asn Gly Glu His Arg Ser Val
    4210                4215                4220                
Leu Ala Ser Ala Asn Leu Gly Trp Pro Asn Gly Leu Ser Ile Asp Tyr
4225                4230                4235               4240 
Leu Asn Gly Asp Arg Ile Tyr Trp Ser Asp Ser Lys Glu Asp Val Ile
                4245                4250                4255    
Glu Ser Ile Lys Tyr Asp Gly Thr Asp Arg Arg Leu Ile Ile Asn Asp
            4260                4265                4270        
Ala Met Lys Pro Phe Ser Leu Asp Ile Phe Glu Asp Gln Leu Tyr Trp
        4275                4280                4285            
Val Ala Lys Glu Lys Gly Glu Val Trp Arg Gln Asn Lys Phe Gly Lys
    4290                4295                4300                
Gly Asn Lys Glu Lys Leu Leu Val Val Asn Pro Trp Leu Thr Gln Val
4305                4310                4315               4320 
Arg Ile Phe His Gln Leu Arg Tyr Asn Gln Ser Val Ser Asn Pro Cys
                4325                4330                4335    
Lys Gln Val Cys Ser His Leu Cys Leu Leu Arg Pro Gly Gly Tyr Ser
            4340                4345                4350        
Cys Ala Cys Pro Gln Gly Ser Asp Phe Val Thr Gly Ser Thr Val Glu
        4355                4360                4365            
Cys Asp Ala Ala Ser Glu Leu Pro Ile Thr Met Pro Ser Pro Cys Arg
    4370                4375                4380                
Cys Met His Gly Gly Ser Cys Tyr Phe Asp Glu Asn Asp Leu Pro Lys
4385                4390                4395               4400 
Cys Lys Cys Ser Ser Gly Tyr Ser Gly Glu Tyr Cys Glu Ile Gly Leu
                4405                4410                4415    
Ser Arg Gly Ile Pro Pro Gly Thr Thr Met Ala Leu Leu Leu Thr Phe
            4420                4425                4430        
Ala Met Val Ile Ile Val Gly Ala Leu Val Leu Val Gly Phe Phe His
        4435                4440                4445            
Tyr Arg Lys Thr Gly Ser Leu Leu Pro Ser Leu Pro Lys Leu Pro Ser
    4450                4455                4460                
Leu Ser Ser Leu Ala Lys Pro Ser Glu Asn Gly Asn Gly Val Thr Phe
4465                4470                4475               4480 
Arg Ser Gly Ala Asp Val Asn Met Asp Ile Gly Val Ser Pro Phe Gly
                4485                4490                4495    
Pro Glu Thr Ile Ile Asp Arg Ser Met Ala Met Asn Glu Gln Phe Val
            4500                4505                4510        
Met Glu Val Gly Lys Gln Pro Val Ile Phe Glu Asn Pro Met Tyr Ala
        4515                4520                4525            
Ala Lys Asp Ser Thr Ser Lys Val Gly Leu Ala Val Gln Gly Pro Ser
    4530                4535                4540                
Val Ser Ser Gln Val Thr Val Pro Glu Asn Val Glu Asn Gln Asn Tyr
4545                4550                4555               4560 
Gly Arg Ser Ile Asp Pro Ser Glu Ile Val Pro Glu Pro Lys Pro Ala
                4565                4570                4575    
Ser Pro Gly Ala Asp Glu Thr Gln Gly Thr Lys Trp Asn Ile Phe Lys
            4580                4585                4590        
Arg Lys Pro Lys Gln Thr Thr Asn Phe Glu Asn Pro Ile Tyr Ala Glu
        4595                4600                4605            
Met Asp Thr Glu Gln Lys Glu Ala Val Ala Val Ala Pro Pro Pro Ser
    4610                4615                4620                
Pro Ser Leu Pro Ala Lys Ala Ser Lys Arg Ser Ser Thr Pro Gly Tyr
4625                4630                4635               4640 
Thr Ala Thr Glu Asp Thr Phe Lys Asp Thr Ala Asn Leu Val Lys Glu
                4645                4650                4655    
Asp Ser Asp Val
            4660


<210> 3
<211> 373
<212> PRT
<213> Homo Sapiens

<400> 3
Leu Arg Pro Val Leu Pro Thr Gln Ser Ala His Asp Pro Pro Ala Val
 1               5                  10                  15      
His Leu Ser Asn Gly Pro Gly Gln Glu Pro Ile Ala Val Met Thr Phe
            20                  25                  30          
Asp Leu Thr Lys Ile Thr Lys Thr Ser Ser Ser Phe Glu Val Arg Thr
        35                  40                  45              
Trp Asp Pro Glu Gly Val Ile Phe Tyr Gly Asp Thr Asn Pro Lys Asp
    50                  55                  60                  
Asp Trp Phe Met Leu Gly Leu Arg Asp Gly Arg Pro Glu Ile Gln Leu
65                  70                  75                  80  
His Asn His Trp Ala Gln Leu Thr Val Gly Ala Gly Pro Arg Leu Asp
                85                  90                  95      
Asp Gly Arg Trp His Gln Val Glu Val Lys Met Glu Gly Asp Ser Val
            100                 105                 110         
Leu Leu Glu Val Asp Gly Glu Glu Val Leu Arg Leu Arg Gln Val Ser
        115                 120                 125             
Gly Pro Leu Thr Ser Lys Arg His Pro Ile Met Arg Ile Ala Leu Gly
    130                 135                 140                 
Gly Leu Leu Phe Pro Ala Ser Asn Leu Arg Leu Pro Leu Val Pro Ala
145                 150                 155                 160 
Leu Asp Gly Cys Leu Arg Arg Asp Ser Trp Leu Asp Lys Gln Ala Glu
                165                 170                 175     
Ile Ser Ala Ser Ala Pro Thr Ser Leu Arg Ser Cys Asp Val Glu Ser
            180                 185                 190         
Asn Pro Gly Ile Phe Leu Pro Pro Gly Thr Gln Ala Glu Phe Asn Leu
        195                 200                 205             
Arg Asp Ile Pro Gln Pro His Ala Glu Pro Trp Ala Phe Ser Leu Asp
    210                 215                 220                 
Leu Gly Leu Lys Gln Ala Ala Gly Ser Gly His Leu Leu Ala Leu Gly
225                 230                 235                 240 
Thr Pro Glu Asn Pro Ser Trp Leu Ser Leu His Leu Gln Asp Gln Lys
                245                 250                 255     
Val Val Leu Ser Ser Gly Ser Gly Pro Gly Leu Asp Leu Pro Leu Val
            260                 265                 270         
Leu Gly Leu Pro Leu Gln Leu Lys Leu Ser Met Ser Arg Val Val Leu
        275                 280                 285             
Ser Gln Gly Ser Lys Met Lys Ala Leu Ala Leu Pro Pro Leu Gly Leu
    290                 295                 300                 
Ala Pro Leu Leu Asn Leu Trp Ala Lys Pro Gln Gly Arg Leu Phe Leu
305                 310                 315                 320 
Gly Ala Leu Pro Gly Glu Asp Ser Ser Thr Ser Phe Cys Leu Asn Gly
                325                 330                 335     
Leu Trp Ala Gln Gly Gln Arg Leu Asp Val Asp Gln Ala Leu Asn Arg
            340                 345                 350         
Ser His Glu Ile Trp Thr His Ser Cys Pro Gln Ser Pro Gly Asn Gly
        355                 360                 365             
Thr Asp Ala Ser His
    370             


<210> 4
<211> 284
<212> PRT
<213> Mus Musculus

<400> 4
Ser Gly Gln Glu Cys Asp Ser Ala His Phe Arg Cys Gly Ser Gly His
 1               5                  10                  15      
Cys Ile Pro Ala Asp Trp Arg Cys Asp Gly Thr Lys Asp Cys Ser Asp
            20                  25                  30          
Asp Ala Asp Glu Ile Gly Cys Ala Val Val Thr Cys Gln Gln Gly Tyr
        35                  40                  45              
Phe Lys Cys Gln Ser Glu Gly Gln Cys Ile Pro Asn Ser Trp Val Cys
    50                  55                  60                  
Asp Gln Asp Gln Asp Cys Asp Asp Gly Ser Asp Glu Arg Gln Asp Cys
65                  70                  75                  80  
Ser Gln Ser Thr Cys Ser Ser His Gln Ile Thr Cys Ser Asn Gly Gln
                85                  90                  95      
Cys Ile Pro Ser Glu Tyr Arg Cys Asp His Val Arg Asp Cys Pro Asp
            100                 105                 110         
Gly Ala Asp Glu Asn Asp Cys Gln Tyr Pro Thr Cys Glu Gln Leu Thr
        115                 120                 125             
Cys Asp Asn Gly Ala Cys Tyr Asn Thr Ser Gln Lys Cys Asp Trp Lys
    130                 135                 140                 
Val Asp Cys Arg Asp Ser Ser Asp Glu Ile Asn Cys Thr Glu Ile Cys
145                 150                 155                 160 
Leu His Asn Glu Phe Ser Cys Gly Asn Gly Glu Cys Ile Pro Arg Ala
                165                 170                 175     
Tyr Val Cys Asp His Asp Asn Asp Cys Gln Asp Gly Ser Asp Glu His
            180                 185                 190         
Ala Cys Asn Tyr Pro Thr Cys Gly Gly Tyr Gln Phe Thr Cys Pro Ser
        195                 200                 205             
Gly Arg Cys Ile Tyr Gln Asn Trp Val Cys Asp Gly Glu Asp Asp Cys
    210                 215                 220                 
Lys Asp Asn Gly Asp Glu Asp Gly Cys Glu Ser Gly Pro His Asp Val
225                 230                 235                 240 
His Lys Cys Ser Pro Arg Glu Trp Ser Cys Pro Glu Ser Gly Arg Cys
                245                 250                 255     
Ile Ser Ile Tyr Lys Val Cys Asp Gly Ile Leu Asp Cys Pro Gly Arg
            260                 265                 270         
Glu Asp Glu Asn Asn Thr Ser Thr Gly Lys Tyr Cys
        275                 280                 


<210> 5
<211> 336
<212> PRT
<213> Mus Musculus

<400> 5
Pro Ala Arg Glu Pro Pro Thr Gln Gln Cys Gly Ser Ser Ser Phe Pro
 1               5                  10                  15      
Cys Asn Asn Gly Lys Cys Val Pro Ser Ile Phe Arg Cys Asp Gly Val
            20                  25                  30          
Asp Asp Cys His Asp Asn Ser Asp Glu His Gln Cys Gly Ala Leu Asn
        35                  40                  45              
Asn Thr Cys Ser Ser Ser Ala Phe Thr Cys Val His Gly Gly Gln Cys
    50                  55                  60                  
Ile Pro Gly Gln Trp Arg Cys Asp Lys Gln Asn Asp Cys Leu Asp Gly
65                  70                  75                  80  
Ser Asp Glu Gln Asn Cys Pro Thr Arg Ser Pro Ser Ser Thr Cys Pro
                85                  90                  95      
Pro Thr Ser Phe Thr Cys Asp Asn His Met Cys Ile Pro Lys Glu Trp
            100                 105                 110         
Val Cys Asp Thr Asp Asn Asp Cys Ser Asp Gly Ser Asp Glu Lys Asn
        115                 120                 125             
Cys Gln Ala Ser Gly Thr Cys His Pro Thr Gln Phe Arg Cys Pro Asp
    130                 135                 140                 
His Arg Cys Ile Ser Pro Leu Tyr Val Cys Asp Gly Asp Lys Asp Cys
145                 150                 155                 160 
Val Asp Gly Ser Asp Glu Ala Gly Cys Val Leu Asn Cys Thr Ser Ser
                165                 170                 175     
Gln Phe Lys Cys Ala Asp Gly Ser Ser Cys Ile Asn Ser Arg Tyr Arg
            180                 185                 190         
Cys Asp Gly Val Tyr Asp Cys Lys Asp Asn Ser Asp Glu Ala Gly Cys
        195                 200                 205             
Pro Thr Arg Pro Pro Gly Met Cys His Pro Asp Glu Phe Gln Cys Gln
    210                 215                 220                 
Gly Asp Gly Thr Cys Ile Pro Asn Thr Trp Glu Cys Asp Gly His Pro
225                 230                 235                 240 
Asp Cys Ile Gln Gly Ser Asp Glu His Asn Gly Cys Val Pro Lys Thr
                245                 250                 255     
Cys Ser Pro Ser His Phe Leu Cys Asp Asn Gly Asn Cys Ile Tyr Asn
            260                 265                 270         
Ser Trp Val Cys Asp Gly Asp Asn Asp Cys Arg Asp Met Ser Asp Glu
        275                 280                 285             
Lys Asp Cys Pro Thr Gln Pro Phe His Cys Pro Ser Ser Gln Trp Gln
    290                 295                 300                 
Cys Pro Gly Tyr Ser Ile Cys Val Asn Leu Ser Ala Leu Cys Asp Gly
305                 310                 315                 320 
Val Phe Asp Cys Pro Asn Gly Thr Asp Glu Ser Pro Leu Cys Asn Gln
                325                 330                 335     


<210> 6
<211> 477
<212> PRT
<213> Mus Musculus

<400> 6
Gln Pro Ser Gly Ile Ser Thr Val Val Lys Thr Gln Gln Gln Gln Cys
 1               5                  10                  15      
Ser Asn Pro Cys Asp Gln Phe Asn Gly Gly Cys Ser His Ile Cys Ala
            20                  25                  30          
Pro Gly Pro Asn Gly Ala Glu Cys Gln Cys Pro His Glu Gly Ser Trp
        35                  40                  45              
Tyr Leu Ala Asn Asp Asn Lys Tyr Cys Val Val Asp Thr Gly Ala Arg
    50                  55                  60                  
Cys Asn Gln Phe Gln Phe Thr Cys Leu Asn Gly Arg Cys Ile Ser Gln
65                  70                  75                  80  
Asp Trp Lys Cys Asp Asn Asp Asn Asp Cys Gly Asp Gly Ser Asp Glu
                85                  90                  95      
Leu Pro Thr Val Cys Ala Phe His Thr Cys Arg Ser Thr Ala Phe Thr
            100                 105                 110         
Cys Ala Asn Gly Arg Cys Val Pro Tyr His Tyr Arg Cys Asp Phe Tyr
        115                 120                 125             
Asn Asp Cys Gly Asp Asn Ser Asp Glu Ala Gly Cys Leu Phe Arg Ser
    130                 135                 140                 
Cys Asn Ser Thr Thr Glu Phe Thr Cys Ser Asn Gly Arg Cys Ile Pro
145                 150                 155                 160 
Leu Ser Tyr Val Cys Asn Gly Ile Asn Asn Cys His Asp Asn Asp Thr
                165                 170                 175     
Ser Asp Glu Lys Asn Cys Pro Pro Ile Thr Cys Gln Pro Asp Phe Ala
            180                 185                 190         
Lys Cys Gln Thr Thr Asn Ile Cys Val Pro Arg Ala Phe Leu Cys Asp
        195                 200                 205             
Gly Asp Asn Asp Cys Gly Asp Gly Ser Asp Glu Asn Pro Ile Tyr Cys
    210                 215                 220                 
Ala Ser His Thr Cys Arg Ser Asn Glu Phe Gln Cys Val Ser Pro His
225                 230                 235                 240 
Arg Cys Ile Pro Ser Tyr Trp Phe Cys Asp Gly Glu Ala Asp Cys Val
                245                 250                 255     
Asp Ser Ser Asp Glu Pro Asp Thr Cys Gly His Ser Leu Asn Ser Cys
            260                 265                 270         
Ser Ala Asn Gln Phe His Cys Asp Asn Gly Arg Cys Ile Ser Ser Ser
        275                 280                 285             
Trp Val Cys Asp Gly Asp Asn Asp Cys Gly Asp Met Ser Asp Glu Asp
    290                 295                 300                 
Gln Arg His His Cys Glu Leu Gln Asn Cys Ser Ser Thr Glu Phe Thr
305                 310                 315                 320 
Cys Ile Asn Ser Arg Pro Pro Asn Arg Arg Cys Ile Pro Gln His Trp
                325                 330                 335     
Val Cys Asp Gly Asp Ala Asp Cys Ala Asp Ala Leu Asp Glu Leu Gln
            340                 345                 350         
Asn Cys Thr Met Arg Ala Cys Ser Thr Gly Glu Phe Ser Cys Ala Asn
        355                 360                 365             
Gly Arg Cys Ile Arg Gln Ser Phe Arg Cys Asp Arg Arg Asn Asp Cys
    370                 375                 380                 
Gly Asp Tyr Ser Asp Glu Arg Gly Cys Ser Tyr Pro Pro Cys Arg Asp
385                 390                 395                 400 
Asp Gln Phe Thr Cys Gln Asn Gly Gln Cys Ile Thr Lys Leu Tyr Val
                405                 410                 415     
Cys Asp Glu Asp Asn Asp Cys Gly Asp Gly Ser Asp Glu Gln Glu His
            420                 425                 430         
Leu Cys His Thr Pro Glu Pro Thr Cys Pro Pro His Gln Phe Arg Cys
        435                 440                 445             
Asp Asn Gly His Cys Ile Glu Met Gly Thr Val Cys Asn His Val Asp
    450                 455                 460                 
Asp Cys Ser Asp Asn Ser Asp Glu Lys Gly Cys Gly Ile
465                 470                 475         


<210> 7
<211> 468
<212> PRT
<213> Mus Musculus

<400> 7
Met Pro Met Cys Ser Ser Thr Gln Phe Leu Cys Gly Asn Asn Glu Lys
 1               5                  10                  15      
Cys Ile Pro Ile Trp Trp Lys Cys Asp Gly Gln Lys Asp Cys Ser Asp
            20                  25                  30          
Gly Ser Asp Glu Ser Asp Leu Cys Pro His Arg Phe Cys Arg Leu Gly
        35                  40                  45              
Gln Phe Gln Cys Arg Asp Gly Asn Cys Thr Ser Pro Gln Ala Leu Cys
    50                  55                  60                  
Asn Ala Arg Gln Asp Cys Ala Asp Gly Ser Asp Glu Asp Arg Val Leu
65                  70                  75                  80  
Cys Glu His His Arg Cys Glu Ala Asn Glu Trp Gln Cys Ala Asn Lys
                85                  90                  95      
Arg Cys Ile Pro Glu Tyr Trp Gln Cys Asp Ser Val Asp Asp Cys Leu
            100                 105                 110         
Asp Asn Ser Asp Glu Asp Pro Ser His Cys Ala Ser Arg Thr Cys Arg
        115                 120                 125             
Pro Gly Gln Phe Lys Cys Asn Asn Gly Arg Cys Ile Pro Gln Ser Trp
    130                 135                 140                 
Lys Cys Asp Val Asp Asn Asp Cys Gly Asp Tyr Ser Asp Glu Pro Ile
145                 150                 155                 160 
His Glu Cys Met Thr Ala Ala Tyr Asn Cys Asp Asn His Thr Glu Phe
                165                 170                 175     
Ser Cys Lys Thr Asn Tyr Arg Cys Ile Pro Gln Trp Ala Val Cys Asn
            180                 185                 190         
Gly Phe Asp Asp Cys Arg Asp Asn Ser Asp Glu Gln Gly Cys Glu Ser
        195                 200                 205             
Val Pro Cys His Pro Ser Gly Asp Phe Arg Cys Gly Asn His His Cys
    210                 215                 220                 
Ile Pro Leu Arg Trp Lys Cys Asp Gly Ile Asp Asp Cys Gly Asp Asn
225                 230                 235                 240 
Ser Asp Glu Glu Ser Cys Val Pro Arg Glu Cys Thr Glu Ser Glu Phe
                245                 250                 255     
Arg Cys Ala Asp Gln Gln Cys Ile Pro Ser Arg Trp Val Cys Asp Gln
            260                 265                 270         
Glu Asn Asp Cys Gly Asp Asn Ser Asp Glu Arg Asp Cys Glu Met Lys
        275                 280                 285             
Thr Cys His Pro Glu His Phe Gln Cys Thr Ser Gly His Cys Val Pro
    290                 295                 300                 
Lys Ala Leu Ala Cys Asp Gly Arg Ala Asp Cys Leu Asp Ala Ser Asp
305                 310                 315                 320 
Glu Ser Ala Cys Pro Thr Arg Phe Pro Asn Gly Thr Tyr Cys Pro Ala
                325                 330                 335     
Ala Met Phe Glu Cys Lys Asn His Val Cys Ile Gln Ser Phe Trp Ile
            340                 345                 350         
Cys Asp Gly Glu Asn Asp Cys Val Asp Gly Ser Asp Glu Glu Ile His
        355                 360                 365             
Leu Cys Phe Asn Val Pro Cys Glu Ser Pro Gln Arg Phe Arg Cys Asp
    370                 375                 380                 
Asn Ser Arg Cys Ile Tyr Gly His Gln Leu Cys Asn Gly Val Asp Asp
385                 390                 395                 400 
Cys Gly Asp Gly Ser Asp Glu Lys Glu Glu His Cys Arg Lys Pro Thr
                405                 410                 415     
His Lys Pro Cys Thr Asp Thr Glu Tyr Lys Cys Ser Asn Gly Asn Cys
            420                 425                 430         
Val Ser Gln His Tyr Val Cys Asp Asn Val Asp Asp Cys Gly Asp Leu
        435                 440                 445             
Ser Asp Glu Thr Gly Cys Asn Leu Gly Glu Asn Arg Thr Cys Ala Glu
    450                 455                 460                 
Lys Ile Cys Glu
465             

