                         SEQUENCE LISTING

<110>  New England Biolabs, Inc.
       Gardner, Andrew
       Greenough, Lucia
       Jack, William
 
<120>  Polymerases for Incorporating Modified Nucleotides

<130>  NEB-307-PCT

<150>  61/046,987
<151>  2008-04-22

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Thermococcus sp. 9 degrees N

<400>  1

Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
1               5                   10              


<210>  2
<211>  13
<212>  PRT
<213>  Pyrococcus furiosus

<400>  2

Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr His 
1               5                   10              


<210>  3
<211>  13
<212>  PRT
<213>  Thermococcus litoralis

<400>  3

Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr His 
1               5                   10              


<210>  4
<211>  13
<212>  PRT
<213>  Thermococcus hydrothermalis

<400>  4

Asp Phe Met Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
1               5                   10              


<210>  5
<211>  775
<212>  PRT
<213>  Thermococcus sp. 9 degrees N

<400>  5

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  6
<211>  775
<212>  PRT
<213>  Thermococcus sp. 9 degrees N DNAP mutant

<400>  6

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Ala Ile Ala Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Pro Ala Pro Thr Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  7
<211>  773
<212>  PRT
<213>  Thermococcus gorgonarius

<400>  7

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  8
<211>  774
<212>  PRT
<213>  Thermococcus kodakarensis

<400>  8

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Gly Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Gln Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Pro Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Tyr 
    370                 375                 380                 


Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Asn Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  9
<211>  775
<212>  PRT
<213>  Pyrococcus horikoshii

<400>  9

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Ala Ile 
        35                  40                  45              


Asp Glu Ile Lys Lys Ile Thr Ala Gln Arg His Gly Lys Val Val Arg 
    50                  55                  60                  


Ile Val Glu Thr Glu Lys Ile Gln Arg Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Thr Pro 
        115                 120                 125             


Met Glu Gly Asn Glu Lys Leu Thr Phe Leu Ala Val Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Val Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Leu Ile Arg Val Ile Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu Leu Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Leu Leu Gly Arg Asp Asn Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Lys Met Gly Asp Ser Leu Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Phe Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ala Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Glu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Ile Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Lys Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly Gln Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Lys Arg Met Lys Glu Ser Lys Asp Pro Val Glu Lys Lys Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Gln Tyr Ile Asp Leu Val Arg Arg Glu 
        515                 520                 525             


Leu Glu Ala Arg Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly Leu 
    530                 535                 540                 


Tyr Ala Thr Ile Pro Gly Val Lys Asp Trp Glu Glu Val Lys Arg Arg 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ser Lys Leu Pro Gly Val Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Ala Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Val Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Asp Val Thr Glu Lys Leu Thr Asn Tyr Glu Val 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Ile Asn 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Met 
        675                 680                 685             


Ala Arg Gly Ile Lys Val Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Ser Ile Glu Glu 
705                 710                 715                 720 


Phe Asp Pro Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Lys 
            740                 745                 750         


Arg Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Val Gly Leu Gly Ala 
        755                 760                 765             


Trp Ile Lys Val Lys Lys Ser 
    770                 775 


<210>  10
<211>  773
<212>  PRT
<213>  Thermococcus aggregans

<400>  10

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Asp Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Val Val Asp Ala Val Lys Val Lys Lys Lys Phe Leu Gly Arg Asp Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Leu 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Met Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Ile Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Thr Leu Leu Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile His Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Glu Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Arg Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Tyr Leu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ala Tyr Leu Asp Phe Ser Leu Tyr Pro Ser Ile Ile Val 
                405                 410                 415     


Thr His Asn Val Ser Pro Asp Thr Leu Glu Arg Glu Gly Cys Lys Asn 
            420                 425                 430         


Tyr Asp Val Ala Pro Ile Val Gly Tyr Lys Phe Cys Lys Asp Phe Pro 
        435                 440                 445             


Gly Phe Ile Pro Ser Ile Leu Gly Glu Leu Ile Thr Met Arg Gln Glu 
    450                 455                 460                 


Ile Lys Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Met 
465                 470                 475                 480 


Leu Asp Tyr Arg Gln Arg Ala Val Lys Leu Leu Ala Asn Ser Tyr Tyr 
                485                 490                 495     


Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala 
            500                 505                 510         


Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Lys 
        515                 520                 525             


Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp 
    530                 535                 540                 


Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Thr Ile Lys Lys 
545                 550                 555                 560 


Lys Ala Lys Glu Phe Leu Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu 
                565                 570                 575     


Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Ala 
            580                 585                 590         


Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg 
        595                 600                 605             


Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr 
    610                 615                 620                 


Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Asp Ser Val Glu Lys 
625                 630                 635                 640 


Ala Val Glu Ile Val Lys Asp Val Val Glu Glu Ile Ala Lys Tyr Gln 
                645                 650                 655     


Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Lys Asp Leu 
            660                 665                 670         


Ser Glu Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg Leu 
        675                 680                 685             


Ala Ala Lys Gly Ile Lys Val Arg Pro Gly Thr Ile Ile Ser Tyr Ile 
    690                 695                 700                 


Val Leu Arg Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Ser 
705                 710                 715                 720 


Glu Tyr Asp Pro Lys Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu 
                725                 730                 735     


Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr 
            740                 745                 750         


Arg Lys Glu Asp Leu Lys Tyr Gln Ser Ser Lys Gln Val Gly Leu Asp 
        755                 760                 765             


Ala Trp Leu Lys Lys 
    770             


<210>  11
<211>  774
<212>  PRT
<213>  Thermococcus litoralis

<400>  11

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Tyr Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  12
<211>  784
<212>  PRT
<213>  Methanococcus maripaludis

<400>  12

Met Glu Ser Leu Ile Asp Leu Asp Tyr Asn Ser Asp Asp Leu Cys Ile 
1               5                   10                  15      


Tyr Leu Tyr Leu Ile Asn Ser Ile Ile Lys Glu Lys Asp Phe Lys Pro 
            20                  25                  30          


Tyr Phe Tyr Val Asn Ser Thr Asp Lys Glu Gln Ile Leu Glu Phe Leu 
        35                  40                  45              


Lys Asp Tyr Glu Lys Lys His Lys Leu Asp Ser Glu Ile Ser Lys Met 
    50                  55                  60                  


Ile Glu Asn Ile Glu Thr Val Lys Lys Ile Val Phe Asp Glu Asn Tyr 
65                  70                  75                  80  


Gln Glu Lys Glu Leu Ser Lys Val Thr Val Lys Tyr Pro Asn Asn Val 
                85                  90                  95      


Lys Thr Val Arg Glu Ile Leu Met Glu Phe Glu Arg Leu Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Val Arg Arg Tyr Leu Ile Asp Asn Ser Val Ile Pro 
        115                 120                 125             


Thr Ser Thr Trp Asp Phe Glu Asn Asn Lys Lys Ile Asp Asn Lys Ile 
    130                 135                 140                 


Pro Asp Phe Lys Thr Val Ser Phe Asp Ile Glu Val Tyr Cys Asn Lys 
145                 150                 155                 160 


Glu Pro Asn Pro Lys Lys Asp Pro Ile Ile Met Ala Ser Phe Ser Ser 
                165                 170                 175     


Lys Asp Phe Asn Thr Val Val Ser Thr Lys Lys Phe Asp His Glu Lys 
            180                 185                 190         


Leu Glu Tyr Val Lys Asp Glu Lys Glu Leu Ile Lys Arg Ile Ile Glu 
        195                 200                 205             


Ile Leu Lys Glu Tyr Asp Ile Ile Tyr Thr Tyr Asn Gly Asp Asn Phe 
    210                 215                 220                 


Asp Phe Pro Tyr Leu Lys Lys Arg Ala Glu Ser Phe Gly Leu Glu Leu 
225                 230                 235                 240 


Lys Leu Gly Lys Asn Asp Glu Lys Ile Lys Ile Thr Lys Gly Gly Met 
                245                 250                 255     


Asn Ser Lys Ser Tyr Ile Pro Gly Arg Val His Ile Asp Leu Tyr Pro 
            260                 265                 270         


Ile Ala Arg Arg Leu Leu Asn Leu Thr Lys Tyr Arg Leu Glu Asn Val 
        275                 280                 285             


Thr Glu Ala Leu Phe Asp Val Lys Lys Val Asp Val Gly His Glu Asn 
    290                 295                 300                 


Ile Pro Lys Met Trp Asp Asn Leu Asp Glu Thr Leu Val Glu Tyr Ser 
305                 310                 315                 320 


His Gln Asp Ala Tyr Tyr Thr Gln Arg Ile Gly Glu Gln Phe Leu Pro 
                325                 330                 335     


Leu Glu Ile Met Phe Ser Arg Val Val Asn Gln Ser Leu Tyr Asp Ile 
            340                 345                 350         


Asn Arg Met Ser Ser Ser Gln Met Val Glu Tyr Leu Leu Leu Lys Asn 
        355                 360                 365             


Ser Tyr Lys Met Gly Val Ile Ala Pro Asn Arg Pro Ser Gly Lys Glu 
    370                 375                 380                 


Tyr Gln Lys Arg Ile Arg Ser Ser Tyr Glu Gly Gly Tyr Val Lys Glu 
385                 390                 395                 400 


Pro Leu Lys Gly Ile His Glu Asp Ile Val Ser Met Asp Phe Leu Ser 
                405                 410                 415     


Leu Tyr Pro Ser Ile Ile Met Ser His Asn Leu Ser Pro Glu Thr Ile 
            420                 425                 430         


Asp Cys Thr Cys Cys Ser Asp Glu Glu Asn Gly Glu Asn Glu Glu Ile 
        435                 440                 445             


Leu Gly His Lys Phe Cys Lys Lys Ser Ile Gly Ile Ile Pro Lys Thr 
    450                 455                 460                 


Leu Met Asp Leu Ile Asn Arg Arg Lys Lys Val Lys Lys Val Leu Arg 
465                 470                 475                 480 


Glu Lys Ala Glu Lys Gly Glu Phe Asp Glu Glu Tyr Gln Ile Leu Asp 
                485                 490                 495     


Tyr Glu Gln Arg Ser Ile Lys Val Leu Ala Asn Ser His Tyr Gly Tyr 
            500                 505                 510         


Leu Ala Phe Pro Met Ala Arg Trp Tyr Ser Arg Asp Cys Ala Glu Ile 
        515                 520                 525             


Thr Thr His Leu Gly Arg Gln Tyr Ile Gln Lys Thr Ile Glu Glu Ala 
    530                 535                 540                 


Glu Asn Phe Gly Phe Lys Val Ile Tyr Ala Asp Thr Asp Gly Phe Tyr 
545                 550                 555                 560 


Ser Lys Trp Ala Asp Asp Lys Glu Lys Leu Ser Lys Tyr Glu Leu Leu 
                565                 570                 575     


Glu Lys Thr Arg Glu Phe Leu Lys Asn Ile Asn Asn Thr Leu Pro Gly 
            580                 585                 590         


Glu Met Glu Leu Glu Phe Glu Gly Tyr Phe Lys Arg Gly Ile Phe Val 
        595                 600                 605             


Thr Lys Lys Lys Tyr Ala Leu Ile Asp Glu Asn Glu Lys Ile Thr Val 
    610                 615                 620                 


Lys Gly Leu Glu Val Val Arg Arg Asp Trp Ser Asn Val Ser Lys Asn 
625                 630                 635                 640 


Thr Gln Lys Asn Val Leu Asn Ala Leu Leu Lys Glu Gly Ser Val Glu 
                645                 650                 655     


Asn Ala Lys Lys Val Ile Gln Asp Thr Ile Lys Glu Leu Lys Asp Gly 
            660                 665                 670         


Lys Val Asn Asn Glu Asp Leu Leu Ile His Thr Gln Leu Thr Lys Arg 
        675                 680                 685             


Ile Glu Asp Tyr Lys Thr Thr Ala Pro His Val Glu Val Ala Lys Lys 
    690                 695                 700                 


Ile Leu Lys Ser Gly Asn Arg Val Asn Thr Gly Asp Val Ile Ser Tyr 
705                 710                 715                 720 


Ile Ile Thr Ser Gly Asn Lys Ser Ile Ser Glu Arg Ala Glu Ile Leu 
                725                 730                 735     


Glu Asn Ala Lys Asn Tyr Asp Thr Asn Tyr Tyr Ile Glu Asn Gln Ile 
            740                 745                 750         


Leu Pro Pro Val Ile Arg Leu Met Glu Ala Leu Gly Ile Thr Lys Asp 
        755                 760                 765             


Glu Leu Lys Asp Ser Lys Lys Gln Tyr Thr Leu His His Phe Leu Lys 
    770                 775                 780                 


<210>  13
<211>  789
<212>  PRT
<213>  Methanococcus jannaschii


<220>
<221>  misc_feature
<222>  (382)..(382)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Met Gly Met Ser Met Gly Lys Ile Lys Ile Asp Ala Leu Ile Asp Asn 
1               5                   10                  15      


Thr Tyr Lys Thr Ile Glu Asp Lys Ala Val Ile Tyr Leu Tyr Leu Ile 
            20                  25                  30          


Asn Ser Ile Leu Lys Asp Arg Asp Phe Lys Pro Tyr Phe Tyr Val Glu 
        35                  40                  45              


Leu His Lys Glu Lys Val Glu Asn Glu Asp Ile Glu Lys Ile Lys Glu 
    50                  55                  60                  


Phe Leu Leu Lys Asn Asp Leu Leu Lys Phe Val Glu Asn Ile Glu Val 
65                  70                  75                  80  


Val Lys Lys Ile Ile Leu Arg Lys Glu Lys Glu Val Ile Lys Ile Ile 
                85                  90                  95      


Ala Thr His Pro Gln Lys Val Pro Lys Leu Arg Lys Ile Lys Glu Cys 
            100                 105                 110         


Glu Ile Val Lys Glu Ile Tyr Glu His Asp Ile Pro Phe Ala Lys Arg 
        115                 120                 125             


Tyr Leu Ile Asp Asn Glu Ile Ile Pro Met Thr Tyr Trp Asp Phe Glu 
    130                 135                 140                 


Asn Lys Lys Pro Val Ser Ile Glu Ile Pro Lys Leu Lys Ser Val Ala 
145                 150                 155                 160 


Phe Asp Met Glu Val Tyr Asn Arg Asp Thr Glu Pro Asn Pro Glu Arg 
                165                 170                 175     


Asp Pro Ile Leu Met Ala Ser Phe Trp Asp Glu Asn Gly Gly Lys Val 
            180                 185                 190         


Ile Thr Tyr Lys Glu Phe Asn His Pro Asn Ile Glu Val Val Lys Asn 
        195                 200                 205             


Glu Lys Glu Leu Ile Lys Lys Ile Ile Glu Thr Leu Lys Glu Tyr Asp 
    210                 215                 220                 


Val Ile Tyr Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu Lys 
225                 230                 235                 240 


Ala Arg Ala Lys Ile Tyr Gly Ile Asp Ile Asn Leu Gly Lys Asp Gly 
                245                 250                 255     


Glu Glu Leu Lys Ile Lys Arg Gly Gly Met Glu Tyr Arg Ser Tyr Ile 
            260                 265                 270         


Pro Gly Arg Val His Ile Asp Leu Tyr Pro Ile Ser Arg Arg Leu Leu 
        275                 280                 285             


Lys Leu Thr Lys Tyr Thr Leu Glu Asp Val Val Tyr Asn Leu Phe Gly 
    290                 295                 300                 


Ile Glu Lys Leu Lys Ile Pro His Thr Lys Ile Val Asp Tyr Trp Ala 
305                 310                 315                 320 


Asn Asn Asp Lys Thr Leu Ile Glu Tyr Ser Leu Gln Asp Ala Lys Tyr 
                325                 330                 335     


Thr Tyr Lys Ile Gly Lys Tyr Phe Phe Pro Leu Glu Val Met Phe Ser 
            340                 345                 350         


Arg Ile Val Asn Gln Thr Pro Phe Glu Ile Thr Arg Met Ser Ser Gly 
        355                 360                 365             


Gln Met Val Glu Tyr Leu Leu Met Lys Arg Ala Phe Lys Xaa Asn Met 
    370                 375                 380                 


Ile Val Pro Asn Lys Pro Asp Glu Glu Glu Tyr Arg Arg Arg Val Leu 
385                 390                 395                 400 


Thr Thr Tyr Glu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Met Phe 
                405                 410                 415     


Glu Asp Ile Ile Ser Met Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
            420                 425                 430         


Ile Ser Tyr Asn Ile Ser Pro Asp Thr Leu Asp Cys Glu Cys Cys Lys 
        435                 440                 445             


Asp Val Ser Glu Lys Ile Leu Gly His Trp Phe Cys Lys Lys Lys Glu 
    450                 455                 460                 


Gly Leu Ile Pro Lys Thr Leu Arg Asn Leu Ile Glu Arg Arg Ile Asn 
465                 470                 475                 480 


Ile Lys Arg Arg Met Lys Lys Met Ala Glu Ile Gly Glu Ile Asn Glu 
                485                 490                 495     


Glu Tyr Asn Leu Leu Asp Tyr Glu Gln Lys Ser Leu Lys Ile Leu Ala 
            500                 505                 510         


Asn Ser Val Tyr Gly Tyr Leu Ala Phe Pro Arg Ala Arg Phe Tyr Ser 
        515                 520                 525             


Arg Glu Cys Ala Glu Ile Val Thr Tyr Leu Gly Arg Lys Tyr Ile Leu 
    530                 535                 540                 


Glu Thr Val Lys Glu Ala Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile 
545                 550                 555                 560 


Asp Thr Asp Gly Phe Tyr Ala Ile Trp Lys Glu Lys Ile Ser Lys Glu 
                565                 570                 575     


Glu Leu Ile Lys Lys Ala Met Glu Phe Val Glu Tyr Ile Asn Ser Lys 
            580                 585                 590         


Leu Pro Gly Thr Met Glu Leu Glu Phe Glu Gly Tyr Phe Lys Arg Gly 
        595                 600                 605             


Ile Phe Val Thr Lys Lys Arg Tyr Ala Leu Ile Asp Glu Asn Gly Arg 
    610                 615                 620                 


Val Thr Val Lys Gly Leu Glu Phe Val Arg Arg Asp Trp Ser Asn Ile 
625                 630                 635                 640 


Ala Lys Ile Thr Gln Arg Arg Val Leu Glu Ala Leu Leu Val Glu Gly 
                645                 650                 655     


Ser Ile Glu Lys Ala Lys Lys Ile Ile Gln Asp Val Ile Lys Asp Leu 
            660                 665                 670         


Arg Glu Lys Lys Ile Lys Lys Glu Asp Leu Ile Ile Tyr Thr Gln Leu 
        675                 680                 685             


Thr Lys Asp Pro Lys Glu Tyr Lys Thr Thr Ala Pro His Val Glu Ile 
    690                 695                 700                 


Ala Lys Lys Leu Met Arg Glu Gly Lys Arg Ile Lys Val Gly Asp Ile 
705                 710                 715                 720 


Ile Gly Tyr Ile Ile Val Lys Gly Thr Lys Ser Ile Ser Glu Arg Ala 
                725                 730                 735     


Lys Leu Pro Glu Glu Val Asp Ile Asp Asp Ile Asp Val Asn Tyr Tyr 
            740                 745                 750         


Ile Asp Asn Gln Ile Leu Pro Pro Val Leu Arg Ile Met Glu Ala Val 
        755                 760                 765             


Gly Val Ser Lys Asn Glu Leu Lys Lys Glu Gly Ala Gln Leu Thr Leu 
    770                 775                 780                 


Asp Lys Phe Phe Lys 
785                 


<210>  14
<211>  586
<212>  PRT
<213>  Methanothermobacter thermautotrophicus str. Delta H.

<400>  14

Met Glu Asp Tyr Arg Met Val Leu Leu Asp Ile Asp Tyr Val Thr Val 
1               5                   10                  15      


Asp Glu Val Pro Val Ile Arg Leu Phe Gly Lys Asp Lys Ser Gly Gly 
            20                  25                  30          


Asn Glu Pro Ile Ile Ala His Asp Arg Ser Phe Arg Pro Tyr Ile Tyr 
        35                  40                  45              


Ala Ile Pro Thr Asp Leu Asp Glu Cys Leu Arg Glu Leu Glu Glu Leu 
    50                  55                  60                  


Glu Leu Glu Lys Leu Glu Val Lys Glu Met Arg Asp Leu Gly Arg Pro 
65                  70                  75                  80  


Thr Glu Val Ile Arg Ile Glu Phe Arg His Pro Gln Asp Val Pro Lys 
                85                  90                  95      


Ile Arg Asp Arg Ile Arg Asp Leu Glu Ser Val Arg Asp Ile Arg Glu 
            100                 105                 110         


His Asp Ile Pro Phe Tyr Arg Arg Tyr Leu Ile Asp Lys Ser Ile Val 
        115                 120                 125             


Pro Met Glu Glu Leu Glu Phe Gln Gly Val Glu Val Asp Ser Ala Pro 
    130                 135                 140                 


Ser Val Thr Thr Asp Val Arg Thr Val Glu Val Thr Gly Arg Val Gln 
145                 150                 155                 160 


Ser Thr Gly Ser Gly Ala His Gly Leu Asp Ile Leu Ser Phe Asp Ile 
                165                 170                 175     


Glu Val Arg Asn Pro His Gly Met Pro Asp Pro Glu Lys Asp Glu Ile 
            180                 185                 190         


Val Met Ile Gly Val Ala Gly Asn Met Gly Tyr Glu Ser Val Ile Ser 
        195                 200                 205             


Thr Ala Gly Asp His Leu Asp Phe Val Glu Val Val Glu Asp Glu Arg 
    210                 215                 220                 


Glu Leu Leu Glu Arg Phe Ala Glu Ile Val Ile Asp Lys Lys Pro Asp 
225                 230                 235                 240 


Ile Leu Val Gly Tyr Asn Ser Asp Asn Phe Asp Phe Pro Tyr Ile Thr 
                245                 250                 255     


Arg Arg Ala Ala Ile Leu Gly Ala Glu Leu Asp Leu Gly Trp Asp Gly 
            260                 265                 270         


Ser Lys Ile Arg Thr Met Arg Arg Gly Phe Ala Asn Ala Thr Ala Ile 
        275                 280                 285             


Lys Gly Thr Val His Val Asp Leu Tyr Pro Val Met Arg Arg Tyr Met 
    290                 295                 300                 


Asn Leu Asp Arg Tyr Thr Leu Glu Arg Val Tyr Gln Glu Leu Phe Gly 
305                 310                 315                 320 


Glu Glu Lys Ile Asp Leu Pro Gly Asp Arg Leu Trp Glu Tyr Trp Asp 
                325                 330                 335     


Arg Asp Glu Leu Arg Asp Glu Leu Phe Arg Tyr Ser Leu Asp Asp Val 
            340                 345                 350         


Val Ala Thr His Arg Ile Ala Glu Lys Ile Leu Pro Leu Asn Leu Glu 
        355                 360                 365             


Leu Thr Arg Leu Val Gly Gln Pro Leu Phe Asp Ile Ser Arg Met Ala 
    370                 375                 380                 


Thr Gly Gln Gln Ala Glu Trp Phe Leu Val Arg Lys Ala Tyr Gln Tyr 
385                 390                 395                 400 


Gly Glu Leu Val Pro Asn Lys Pro Ser Gln Ser Asp Phe Ser Ser Arg 
                405                 410                 415     


Arg Gly Arg Arg Ala Val Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly 
            420                 425                 430         


Leu His Glu Asn Ile Val Gln Phe Asp Phe Arg Ser Leu Tyr Pro Ser 
        435                 440                 445             


Ile Ile Ile Ser Lys Asn Ile Ser Pro Asp Thr Leu Thr Asp Asp Glu 
    450                 455                 460                 


Glu Ser Glu Cys Tyr Val Ala Pro Glu Tyr Gly Tyr Arg Phe Arg Lys 
465                 470                 475                 480 


Ser Pro Arg Gly Phe Val Pro Ser Val Ile Gly Glu Ile Leu Ser Glu 
                485                 490                 495     


Arg Val Arg Ile Lys Glu Glu Met Lys Gly Ser Asp Asp Pro Met Glu 
            500                 505                 510         


Arg Lys Ile Leu Asn Val Gln Gln Glu Ala Leu Lys Arg Leu Ala Asn 
        515                 520                 525             


Thr Met Tyr Gly Val Tyr Gly Tyr Ser Arg Phe Arg Trp Tyr Ser Met 
    530                 535                 540                 


Glu Cys Ala Glu Ala Ile Thr Ala Trp Gly Arg Asp Tyr Ile Lys Lys 
545                 550                 555                 560 


Thr Ile Lys Thr Ala Glu Glu Phe Gly Phe His Thr Val Tyr Ala Asp 
                565                 570                 575     


Thr Asp Gly Phe Tyr Ala Thr Tyr Arg Gly 
            580                 585     


<210>  15
<211>  903
<212>  PRT
<213>  Bacteriophage RB69

<400>  15

Met Lys Glu Phe Tyr Leu Thr Val Glu Gln Ile Gly Asp Ser Ile Phe 
1               5                   10                  15      


Glu Arg Tyr Ile Asp Ser Asn Gly Arg Glu Arg Thr Arg Glu Val Glu 
            20                  25                  30          


Tyr Lys Pro Ser Leu Phe Ala His Cys Pro Glu Ser Gln Ala Thr Lys 
        35                  40                  45              


Tyr Phe Asp Ile Tyr Gly Lys Pro Cys Thr Arg Lys Leu Phe Ala Asn 
    50                  55                  60                  


Met Arg Asp Ala Ser Gln Trp Ile Lys Arg Met Glu Asp Ile Gly Leu 
65                  70                  75                  80  


Glu Ala Leu Gly Met Asp Asp Phe Lys Leu Ala Tyr Leu Ser Asp Thr 
                85                  90                  95      


Tyr Asn Tyr Glu Ile Lys Tyr Asp His Thr Lys Ile Arg Val Ala Asn 
            100                 105                 110         


Phe Asp Ile Glu Val Thr Ser Pro Asp Gly Phe Pro Glu Pro Ser Gln 
        115                 120                 125             


Ala Lys His Pro Ile Asp Ala Ile Thr His Tyr Asp Ser Ile Asp Asp 
    130                 135                 140                 


Arg Phe Tyr Val Phe Asp Leu Leu Asn Ser Pro Tyr Gly Asn Val Glu 
145                 150                 155                 160 


Glu Trp Ser Ile Glu Ile Ala Ala Lys Leu Gln Glu Gln Gly Gly Asp 
                165                 170                 175     


Glu Val Pro Ser Glu Ile Ile Asp Lys Ile Ile Tyr Met Pro Phe Asp 
            180                 185                 190         


Asn Glu Lys Glu Leu Leu Met Glu Tyr Leu Asn Phe Trp Gln Gln Lys 
        195                 200                 205             


Thr Pro Val Ile Leu Thr Gly Trp Asn Val Glu Ser Phe Asp Ile Pro 
    210                 215                 220                 


Tyr Val Tyr Asn Arg Ile Lys Asn Ile Phe Gly Glu Ser Thr Ala Lys 
225                 230                 235                 240 


Arg Leu Ser Pro His Arg Lys Thr Arg Val Lys Val Ile Glu Asn Met 
                245                 250                 255     


Tyr Gly Ser Arg Glu Ile Ile Thr Leu Phe Gly Ile Ser Val Leu Asp 
            260                 265                 270         


Tyr Ile Asp Leu Tyr Lys Lys Phe Ser Phe Thr Asn Gln Pro Ser Tyr 
        275                 280                 285             


Ser Leu Asp Tyr Ile Ser Glu Phe Glu Leu Asn Val Gly Lys Leu Lys 
    290                 295                 300                 


Tyr Asp Gly Pro Ile Ser Lys Leu Arg Glu Ser Asn His Gln Arg Tyr 
305                 310                 315                 320 


Ile Ser Tyr Asn Ile Ile Asp Val Tyr Arg Val Leu Gln Ile Asp Ala 
                325                 330                 335     


Lys Arg Gln Phe Ile Asn Leu Ser Leu Asp Met Gly Tyr Tyr Ala Lys 
            340                 345                 350         


Ile Gln Ile Gln Ser Val Phe Ser Pro Ile Lys Thr Trp Asp Ala Ile 
        355                 360                 365             


Ile Phe Asn Ser Leu Lys Glu Gln Asn Lys Val Ile Pro Gln Gly Arg 
    370                 375                 380                 


Ser His Pro Val Gln Pro Tyr Pro Gly Ala Phe Val Lys Glu Pro Ile 
385                 390                 395                 400 


Pro Asn Arg Tyr Lys Tyr Val Met Ser Phe Asp Leu Thr Ser Leu Tyr 
                405                 410                 415     


Pro Ser Ile Ile Arg Gln Val Asn Ile Ser Pro Glu Thr Ile Ala Gly 
            420                 425                 430         


Thr Phe Lys Val Ala Pro Leu His Asp Tyr Ile Asn Ala Val Ala Glu 
        435                 440                 445             


Arg Pro Ser Asp Val Tyr Ser Cys Ser Pro Asn Gly Met Met Tyr Tyr 
    450                 455                 460                 


Lys Asp Arg Asp Gly Val Val Pro Thr Glu Ile Thr Lys Val Phe Asn 
465                 470                 475                 480 


Gln Arg Lys Glu His Lys Gly Tyr Met Leu Ala Ala Gln Arg Asn Gly 
                485                 490                 495     


Glu Ile Ile Lys Glu Ala Leu His Asn Pro Asn Leu Ser Val Asp Glu 
            500                 505                 510         


Pro Leu Asp Val Asp Tyr Arg Phe Asp Phe Ser Asp Glu Ile Lys Glu 
        515                 520                 525             


Lys Ile Lys Lys Leu Ser Ala Lys Ser Leu Asn Glu Met Leu Phe Arg 
    530                 535                 540                 


Ala Gln Arg Thr Glu Val Ala Gly Met Thr Ala Gln Ile Asn Arg Lys 
545                 550                 555                 560 


Leu Leu Ile Asn Ser Leu Tyr Gly Ala Leu Gly Asn Val Trp Phe Arg 
                565                 570                 575     


Tyr Tyr Asp Leu Arg Asn Ala Thr Ala Ile Thr Thr Phe Gly Gln Met 
            580                 585                 590         


Ala Leu Gln Trp Ile Glu Arg Lys Val Asn Glu Tyr Leu Asn Glu Val 
        595                 600                 605             


Cys Gly Thr Glu Gly Glu Ala Phe Val Leu Tyr Gly Asp Thr Asp Ser 
    610                 615                 620                 


Ile Tyr Val Ser Ala Asp Lys Ile Ile Asp Lys Val Gly Glu Ser Lys 
625                 630                 635                 640 


Phe Arg Asp Thr Asn His Trp Val Asp Phe Leu Asp Lys Phe Ala Arg 
                645                 650                 655     


Glu Arg Met Glu Pro Ala Ile Asp Arg Gly Phe Arg Glu Met Cys Glu 
            660                 665                 670         


Tyr Met Asn Asn Lys Gln His Leu Met Phe Met Asp Arg Glu Ala Ile 
        675                 680                 685             


Ala Gly Pro Pro Leu Gly Ser Lys Gly Ile Gly Gly Phe Trp Thr Gly 
    690                 695                 700                 


Lys Lys Arg Tyr Ala Leu Asn Val Trp Asp Met Glu Gly Thr Arg Tyr 
705                 710                 715                 720 


Ala Glu Pro Lys Leu Lys Ile Met Gly Leu Glu Thr Gln Lys Ser Ser 
                725                 730                 735     


Thr Pro Lys Ala Val Gln Lys Ala Leu Lys Glu Cys Ile Arg Arg Met 
            740                 745                 750         


Leu Gln Glu Gly Glu Glu Ser Leu Gln Glu Tyr Phe Lys Glu Phe Glu 
        755                 760                 765             


Lys Glu Phe Arg Gln Leu Asn Tyr Ile Ser Ile Ala Ser Val Ser Ser 
    770                 775                 780                 


Ala Asn Asn Ile Ala Lys Tyr Asp Val Gly Gly Phe Pro Gly Pro Lys 
785                 790                 795                 800 


Cys Pro Phe His Ile Arg Gly Ile Leu Thr Tyr Asn Arg Ala Ile Lys 
                805                 810                 815     


Gly Asn Ile Asp Ala Pro Gln Val Val Glu Gly Glu Lys Val Tyr Val 
            820                 825                 830         


Leu Pro Leu Arg Glu Gly Asn Pro Phe Gly Asp Lys Cys Ile Ala Trp 
        835                 840                 845             


Pro Ser Gly Thr Glu Ile Thr Asp Leu Ile Lys Asp Asp Val Leu His 
    850                 855                 860                 


Trp Met Asp Tyr Thr Val Leu Leu Glu Lys Thr Phe Ile Lys Pro Leu 
865                 870                 875                 880 


Glu Gly Phe Thr Ser Ala Ala Lys Leu Asp Tyr Glu Lys Lys Ala Ser 
                885                 890                 895     


Leu Phe Asp Met Phe Asp Phe 
            900             


<210>  16
<211>  898
<212>  PRT
<213>  bacteriophage T4

<400>  16

Met Lys Glu Phe Tyr Ile Ser Ile Glu Thr Val Gly Asn Asn Ile Val 
1               5                   10                  15      


Glu Arg Tyr Ile Asp Glu Asn Gly Lys Glu Arg Thr Arg Glu Val Glu 
            20                  25                  30          


Tyr Leu Pro Thr Met Phe Arg His Cys Lys Glu Glu Ser Lys Tyr Lys 
        35                  40                  45              


Asp Ile Tyr Gly Lys Asn Cys Ala Pro Gln Lys Phe Pro Ser Met Lys 
    50                  55                  60                  


Asp Ala Arg Asp Trp Met Lys Arg Met Glu Asp Ile Gly Leu Glu Ala 
65                  70                  75                  80  


Leu Gly Met Asn Asp Phe Lys Leu Ala Tyr Ile Ser Asp Thr Tyr Gly 
                85                  90                  95      


Ser Glu Ile Val Tyr Asp Arg Lys Phe Val Arg Val Ala Asn Cys Asp 
            100                 105                 110         


Ile Glu Val Thr Gly Asp Lys Phe Pro Asp Pro Met Lys Ala Glu Tyr 
        115                 120                 125             


Glu Ile Asp Ala Ile Thr His Tyr Asp Ser Ile Asp Asp Arg Phe Tyr 
    130                 135                 140                 


Val Phe Asp Leu Leu Asn Ser Met Tyr Gly Ser Val Ser Lys Trp Asp 
145                 150                 155                 160 


Ala Lys Leu Ala Ala Lys Leu Asp Cys Glu Gly Gly Asp Glu Val Pro 
                165                 170                 175     


Gln Glu Ile Leu Asp Arg Val Ile Tyr Met Pro Phe Asp Asn Glu Arg 
            180                 185                 190         


Asp Met Leu Met Glu Tyr Ile Asn Leu Trp Glu Gln Lys Arg Pro Ala 
        195                 200                 205             


Ile Phe Thr Gly Trp Asn Ile Glu Gly Phe Asp Val Pro Tyr Ile Met 
    210                 215                 220                 


Asn Arg Val Lys Met Ile Leu Gly Glu Arg Ser Met Lys Arg Phe Ser 
225                 230                 235                 240 


Pro Ile Gly Arg Val Lys Ser Lys Leu Ile Gln Asn Met Tyr Gly Ser 
                245                 250                 255     


Lys Glu Ile Tyr Ser Ile Asp Gly Val Ser Ile Leu Asp Tyr Leu Asp 
            260                 265                 270         


Leu Tyr Lys Lys Phe Ala Phe Thr Asn Leu Pro Ser Phe Ser Leu Glu 
        275                 280                 285             


Ser Val Ala Gln His Glu Thr Lys Lys Gly Lys Leu Pro Tyr Asp Gly 
    290                 295                 300                 


Pro Ile Asn Lys Leu Arg Glu Thr Asn His Gln Arg Tyr Ile Ser Tyr 
305                 310                 315                 320 


Asn Ile Ile Asp Val Glu Ser Val Gln Ala Ile Asp Lys Ile Arg Gly 
                325                 330                 335     


Phe Ile Asp Leu Val Leu Ser Met Ser Tyr Tyr Ala Lys Met Pro Phe 
            340                 345                 350         


Ser Gly Val Met Ser Pro Ile Lys Thr Trp Asp Ala Ile Ile Phe Asn 
        355                 360                 365             


Ser Leu Lys Gly Glu His Lys Val Ile Pro Gln Gln Gly Ser His Val 
    370                 375                 380                 


Lys Gln Ser Phe Pro Gly Ala Phe Val Phe Glu Pro Lys Pro Ile Ala 
385                 390                 395                 400 


Arg Arg Tyr Ile Met Ser Phe Asp Leu Thr Ser Leu Tyr Pro Ser Ile 
                405                 410                 415     


Ile Arg Gln Val Asn Ile Ser Pro Glu Thr Ile Arg Gly Gln Phe Lys 
            420                 425                 430         


Val His Pro Ile His Glu Tyr Ile Ala Gly Thr Ala Pro Lys Pro Ser 
        435                 440                 445             


Asp Glu Tyr Ser Cys Ser Pro Asn Gly Trp Met Tyr Asp Lys His Gln 
    450                 455                 460                 


Glu Gly Ile Ile Pro Lys Glu Ile Ala Lys Val Phe Phe Gln Arg Lys 
465                 470                 475                 480 


Asp Trp Lys Lys Lys Met Phe Ala Glu Glu Met Asn Ala Glu Ala Ile 
                485                 490                 495     


Lys Lys Ile Ile Met Lys Gly Ala Gly Ser Cys Ser Thr Lys Pro Glu 
            500                 505                 510         


Val Glu Arg Tyr Val Lys Phe Ser Asp Asp Phe Leu Asn Glu Leu Ser 
        515                 520                 525             


Asn Tyr Thr Glu Ser Val Leu Asn Ser Leu Ile Glu Glu Cys Glu Lys 
    530                 535                 540                 


Ala Ala Thr Leu Ala Asn Thr Asn Gln Leu Asn Arg Lys Ile Leu Ile 
545                 550                 555                 560 


Asn Ser Leu Tyr Gly Ala Leu Gly Asn Ile His Phe Arg Tyr Tyr Asp 
                565                 570                 575     


Leu Arg Asn Ala Thr Ala Ile Thr Ile Phe Gly Gln Val Gly Ile Gln 
            580                 585                 590         


Trp Ile Ala Arg Lys Ile Asn Glu Tyr Leu Asn Lys Val Cys Gly Thr 
        595                 600                 605             


Asn Asp Glu Asp Phe Ile Ala Ala Gly Asp Thr Asp Ser Val Tyr Val 
    610                 615                 620                 


Cys Val Asp Lys Val Ile Glu Lys Val Gly Leu Asp Arg Phe Lys Glu 
625                 630                 635                 640 


Gln Asn Asp Leu Val Glu Phe Met Asn Gln Phe Gly Lys Lys Lys Met 
                645                 650                 655     


Glu Pro Met Ile Asp Val Ala Tyr Arg Glu Leu Cys Asp Tyr Met Asn 
            660                 665                 670         


Asn Arg Glu His Leu Met His Met Asp Arg Glu Ala Ile Ser Cys Pro 
        675                 680                 685             


Pro Leu Gly Ser Lys Gly Val Gly Gly Phe Trp Lys Ala Lys Lys Arg 
    690                 695                 700                 


Tyr Ala Leu Asn Val Tyr Asp Met Glu Asp Lys Arg Phe Ala Glu Pro 
705                 710                 715                 720 


His Leu Lys Ile Met Gly Met Glu Thr Gln Gln Ser Ser Thr Pro Lys 
                725                 730                 735     


Ala Val Gln Glu Ala Leu Glu Glu Ser Ile Arg Arg Ile Leu Gln Glu 
            740                 745                 750         


Gly Glu Glu Ser Val Gln Glu Tyr Tyr Lys Asn Phe Glu Lys Glu Tyr 
        755                 760                 765             


Arg Gln Leu Asp Tyr Lys Val Ile Ala Glu Val Lys Thr Ala Asn Asp 
    770                 775                 780                 


Ile Ala Lys Tyr Asp Asp Lys Gly Trp Pro Gly Phe Lys Cys Pro Phe 
785                 790                 795                 800 


His Ile Arg Gly Val Leu Thr Tyr Arg Arg Ala Val Ser Gly Leu Gly 
                805                 810                 815     


Val Ala Pro Ile Leu Asp Gly Asn Lys Val Met Val Leu Pro Leu Arg 
            820                 825                 830         


Glu Gly Asn Pro Phe Gly Asp Lys Cys Ile Ala Trp Pro Ser Gly Thr 
        835                 840                 845             


Glu Leu Pro Lys Glu Ile Arg Ser Asp Val Leu Ser Trp Ile Asp His 
    850                 855                 860                 


Ser Thr Leu Phe Gln Lys Ser Phe Val Lys Pro Leu Ala Gly Met Cys 
865                 870                 875                 880 


Glu Ser Ala Gly Met Asp Tyr Glu Glu Lys Ala Ser Leu Asp Phe Leu 
                885                 890                 895     


Phe Gly 
        


<210>  17
<211>  812
<212>  PRT
<213>  methanoculleus marisnigri JR1

<400>  17

Met Ser Val Pro Ala Thr Leu Glu Asp Phe Gly Lys Ile Arg Val Gly 
1               5                   10                  15      


Ile His Gln Val Glu Tyr Gly Asn Val Gly Ala Asp Thr Pro Val Val 
            20                  25                  30          


Tyr Ile Phe Gly Arg Asp Ala Ser Gly Lys Ala Ile Gln Val Arg Val 
        35                  40                  45              


Ser Gly Phe Arg Pro Tyr Phe Tyr Ala Pro Ala Asp Leu Val Asp Gly 
    50                  55                  60                  


Arg Ser Leu Pro Gln Glu Ile Val Gly Val Glu Glu Asn Thr Thr Tyr 
65                  70                  75                  80  


Arg Ser Ile Gln Gly Val Pro Leu Arg Arg Leu Tyr Thr Arg Arg Pro 
                85                  90                  95      


Gly Asp Val Arg Ala Val Arg Asp Val Phe Ser His His Tyr Glu Ala 
            100                 105                 110         


Asp Ile Pro Phe Thr Thr Arg Phe Met Ile Asp Cys Gly Leu Thr Ala 
        115                 120                 125             


Gly Val Glu Leu Pro Ala Gly Ala Val Glu Ser Phe Asp Gly Ala Phe 
    130                 135                 140                 


Glu Ile Glu Cys Cys Glu Leu Ala Pro Ala Glu Ile Lys Ala Pro Ala 
145                 150                 155                 160 


Arg Thr Cys Ile Met Asp Ile Glu Cys Val Asp Glu Gln Gly Phe Pro 
                165                 170                 175     


Glu Pro Glu Arg Asp Pro Ile Ile Cys Val Thr Cys Trp Asp Ser Phe 
            180                 185                 190         


Asp Asp Asp Tyr Thr Thr Leu Leu Trp Gln Pro Gly Glu Ala Ala Gly 
        195                 200                 205             


Asp Ala Pro Asp Leu Cys Val Gln Glu Arg His Arg Val Val Arg Tyr 
    210                 215                 220                 


Pro Asp Glu Ile Ala Met Leu Lys Gly Leu Val Asp Tyr Val Lys Lys 
225                 230                 235                 240 


Arg Asp Pro Asp Ile Leu Ser Gly Trp Asn Phe Val Glu Phe Asp Ile 
                245                 250                 255     


Pro Tyr Ile Val Lys Arg Met Gly Ala Leu Gly Leu Lys Ala Glu Asp 
            260                 265                 270         


Leu Ala Arg Ile Pro Gly Gln Thr Glu Arg Asn Ala Val Arg Gly Arg 
        275                 280                 285             


Ser Ile Phe Asp Leu Leu Gly Ala Tyr Arg Lys Met His Gln Ala Gln 
    290                 295                 300                 


Lys Glu Ser Tyr Arg Leu Asp Ala Ile Ala Gly Glu Glu Leu Gly Val 
305                 310                 315                 320 


Thr Lys Val Arg Tyr Thr Gly Thr Ile Thr Asp Leu Trp Arg Thr Asp 
                325                 330                 335     


Pro Lys Arg Leu Val Glu Tyr Asn Tyr Arg Asp Val Glu Leu Cys Val 
            340                 345                 350         


Gly Ile Asp Gln Lys Asn Asn Ile Ile Glu Phe Tyr Arg Glu Ile Ala 
        355                 360                 365             


Arg Tyr Val Gly Cys Pro Leu Asp Arg Thr Leu Asn Ser Ser Asn Val 
    370                 375                 380                 


Ile Asp Ile Phe Val Leu Arg Lys Ala Ser Gly Thr Phe Val Leu Pro 
385                 390                 395                 400 


Ser Lys Gly Leu Ala Ala Gly Asp Glu Phe Glu Gly Ala Thr Val Phe 
                405                 410                 415     


Glu Pro Ala Thr Gly Leu Arg Glu Asn Val Val Val Leu Asp Leu Lys 
            420                 425                 430         


Ser Leu Tyr Pro Met Ala Met Met Thr Ile Asn Ala Ser Pro Glu Thr 
        435                 440                 445             


Lys Asn Pro Asp Gly Glu Leu Arg Ala Pro Asn Gly Ile Arg Phe Ser 
    450                 455                 460                 


Arg Glu Pro Asp Gly Leu Thr Arg Ser Ile Ile Ala Glu Leu Leu Glu 
465                 470                 475                 480 


Glu Arg Asp Glu Arg Lys Arg Leu Arg Asn Leu Tyr Pro Phe Gly Ser 
                485                 490                 495     


Pro Glu Tyr Val Leu Tyr Asp Leu Gln Gln Asn Val Leu Lys Val Ile 
            500                 505                 510         


Met Asn Ser Tyr Tyr Gly Val Ser Gly Tyr Thr Arg Phe Arg Leu Tyr 
        515                 520                 525             


Asp Arg Glu Ile Gly Ser Ala Val Thr Ser Val Gly Arg Ala Ile Ile 
    530                 535                 540                 


Arg His Thr Arg Asp Ile Ile Thr Asn Leu Gly Tyr Thr Val Leu Tyr 
545                 550                 555                 560 


Gly Asp Thr Asp Ser Cys Met Ile Glu Val Pro Pro Gly Asp Leu Glu 
                565                 570                 575     


Ala Thr Ile Ala Arg Ala Arg Glu Ile Glu Ala Lys Leu Asn Ala Ser 
            580                 585                 590         


Tyr Gly Asp Phe Ala Lys Thr Glu Leu Asn Ala Asp Thr His Tyr Phe 
        595                 600                 605             


Ser Ile Lys Phe Glu Lys Val Tyr Arg Arg Phe Phe Gln Ala Gly Lys 
    610                 615                 620                 


Lys Lys Arg Tyr Ala Gly His Leu Val Trp Lys Glu Gly Lys Asp Val 
625                 630                 635                 640 


Asp Glu Val Asp Val Val Gly Phe Glu Ile Arg Arg Ser Asp Ser Pro 
                645                 650                 655     


Gln Ile Thr Arg Glu Val Gln Arg Ala Val Ile Glu Met Ile Leu Arg 
            660                 665                 670         


Gly Asp Ala Phe Ser Asp Val Gln Ala Tyr Leu Arg Asp Val Ile Arg 
        675                 680                 685             


Lys Tyr Arg Arg Gly Glu Tyr Ser Leu Asp Glu Ala Gly Ile Pro Gly 
    690                 695                 700                 


Gly Ile Gly Lys Ser Leu Asp Ser Tyr Glu Asn Asp Asp Ala His Ile 
705                 710                 715                 720 


Arg Gly Ala Lys Tyr Ser Asn Met His Leu Gly Thr Asp Phe Lys Arg 
                725                 730                 735     


Gly Ser Lys Pro Lys Arg Val Tyr Ile Lys Ala Val Thr Ala Lys Tyr 
            740                 745                 750         


Pro Arg Thr Asp Val Val Cys Phe Glu Tyr Ala Asp Gln Val Pro Pro 
        755                 760                 765             


Glu Phe Val Val Asp Trp Glu Thr Met Leu Glu Lys Thr Leu Lys Gly 
    770                 775                 780                 


Pro Leu Ser Arg Ile Ile Glu Pro Leu Gly Trp Asp Trp His Asp Val 
785                 790                 795                 800 


Asp Pro Ser Arg Thr Thr Leu Phe Asp Phe Gly Met 
                805                 810         


<210>  18
<211>  50
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  18
agtgaattcg agctcggtac ccggggatcc tctagagtcg acctgcaggc                  50


<210>  19
<211>  67
<212>  DNA
<213>  artificial

<220>
<223>  template

<400>  19
tcacttaagc tcgagccatg ggcccctagg agatctcagc tggacgtccg gatcctatac       60

taatccc                                                                 67


<210>  20
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  20
cacgacgttg taaaacgac                                                    19


<210>  21
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  21
cgccagggtt ttcccagtca cgac                                              24


<210>  22
<211>  784
<212>  PRT
<213>  Methanococcus maripaludis


<220>
<221>  MISC_FEATURE
<222>  (1)..(784)
<223>  Exo-

<400>  22

Met Glu Ser Leu Ile Asp Leu Asp Tyr Asn Ser Asp Asp Leu Cys Ile 
1               5                   10                  15      


Tyr Leu Tyr Leu Ile Asn Ser Ile Ile Lys Glu Lys Asp Phe Lys Pro 
            20                  25                  30          


Tyr Phe Tyr Val Asn Ser Thr Asp Lys Glu Gln Ile Leu Glu Phe Leu 
        35                  40                  45              


Lys Asp Tyr Glu Lys Lys His Lys Leu Asp Ser Glu Ile Ser Lys Met 
    50                  55                  60                  


Ile Glu Asn Ile Glu Thr Val Lys Lys Ile Val Phe Asp Glu Asn Tyr 
65                  70                  75                  80  


Gln Glu Lys Glu Leu Ser Lys Val Thr Val Lys Tyr Pro Asn Asn Val 
                85                  90                  95      


Lys Thr Val Arg Glu Ile Leu Met Glu Phe Glu Arg Leu Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Val Arg Arg Tyr Leu Ile Asp Asn Ser Val Ile Pro 
        115                 120                 125             


Thr Ser Thr Trp Asp Phe Glu Asn Asn Lys Lys Ile Asp Asn Lys Ile 
    130                 135                 140                 


Pro Asp Phe Lys Thr Val Ser Phe Ala Ile Ala Val Tyr Cys Asn Lys 
145                 150                 155                 160 


Glu Pro Asn Pro Lys Lys Asp Pro Ile Ile Met Ala Ser Phe Ser Ser 
                165                 170                 175     


Lys Asp Phe Asn Thr Val Val Ser Thr Lys Lys Phe Asp His Glu Lys 
            180                 185                 190         


Leu Glu Tyr Val Lys Asp Glu Lys Glu Leu Ile Lys Arg Ile Ile Glu 
        195                 200                 205             


Ile Leu Lys Glu Tyr Asp Ile Ile Tyr Thr Tyr Asn Gly Asp Asn Phe 
    210                 215                 220                 


Asp Phe Pro Tyr Leu Lys Lys Arg Ala Glu Ser Phe Gly Leu Glu Leu 
225                 230                 235                 240 


Lys Leu Gly Lys Asn Asp Glu Lys Ile Lys Ile Thr Lys Gly Gly Met 
                245                 250                 255     


Asn Ser Lys Ser Tyr Ile Pro Gly Arg Val His Ile Asp Leu Tyr Pro 
            260                 265                 270         


Ile Ala Arg Arg Leu Leu Asn Leu Thr Lys Tyr Arg Leu Glu Asn Val 
        275                 280                 285             


Thr Glu Ala Leu Phe Asp Val Lys Lys Val Asp Val Gly His Glu Asn 
    290                 295                 300                 


Ile Pro Lys Met Trp Asp Asn Leu Asp Glu Thr Leu Val Glu Tyr Ser 
305                 310                 315                 320 


His Gln Asp Ala Tyr Tyr Thr Gln Arg Ile Gly Glu Gln Phe Leu Pro 
                325                 330                 335     


Leu Glu Ile Met Phe Ser Arg Val Val Asn Gln Ser Leu Tyr Asp Ile 
            340                 345                 350         


Asn Arg Met Ser Ser Ser Gln Met Val Glu Tyr Leu Leu Leu Lys Asn 
        355                 360                 365             


Ser Tyr Lys Met Gly Val Ile Ala Pro Asn Arg Pro Ser Gly Lys Glu 
    370                 375                 380                 


Tyr Gln Lys Arg Ile Arg Ser Ser Tyr Glu Gly Gly Tyr Val Lys Glu 
385                 390                 395                 400 


Pro Leu Lys Gly Ile His Glu Asp Ile Val Ser Met Asp Phe Leu Ser 
                405                 410                 415     


Leu Tyr Pro Ser Ile Ile Met Ser His Asn Leu Ser Pro Glu Thr Ile 
            420                 425                 430         


Asp Cys Thr Cys Cys Ser Asp Glu Glu Asn Gly Glu Asn Glu Glu Ile 
        435                 440                 445             


Leu Gly His Lys Phe Cys Lys Lys Ser Ile Gly Ile Ile Pro Lys Thr 
    450                 455                 460                 


Leu Met Asp Leu Ile Asn Arg Arg Lys Lys Val Lys Lys Val Leu Arg 
465                 470                 475                 480 


Glu Lys Ala Glu Lys Gly Glu Phe Asp Glu Glu Tyr Gln Ile Leu Asp 
                485                 490                 495     


Tyr Glu Gln Arg Ser Ile Lys Val Leu Ala Asn Ser His Tyr Gly Tyr 
            500                 505                 510         


Leu Ala Phe Pro Met Ala Arg Trp Tyr Ser Arg Asp Cys Ala Glu Ile 
        515                 520                 525             


Thr Thr His Leu Gly Arg Gln Tyr Ile Gln Lys Thr Ile Glu Glu Ala 
    530                 535                 540                 


Glu Asn Phe Gly Phe Lys Val Ile Tyr Ala Asp Thr Asp Gly Phe Tyr 
545                 550                 555                 560 


Ser Lys Trp Ala Asp Asp Lys Glu Lys Leu Ser Lys Tyr Glu Leu Leu 
                565                 570                 575     


Glu Lys Thr Arg Glu Phe Leu Lys Asn Ile Asn Asn Thr Leu Pro Gly 
            580                 585                 590         


Glu Met Glu Leu Glu Phe Glu Gly Tyr Phe Lys Arg Gly Ile Phe Val 
        595                 600                 605             


Thr Lys Lys Lys Tyr Ala Leu Ile Asp Glu Asn Glu Lys Ile Thr Val 
    610                 615                 620                 


Lys Gly Leu Glu Val Val Arg Arg Asp Trp Ser Asn Val Ser Lys Asn 
625                 630                 635                 640 


Thr Gln Lys Asn Val Leu Asn Ala Leu Leu Lys Glu Gly Ser Val Glu 
                645                 650                 655     


Asn Ala Lys Lys Val Ile Gln Asp Thr Ile Lys Glu Leu Lys Asp Gly 
            660                 665                 670         


Lys Val Asn Asn Glu Asp Leu Leu Ile His Thr Gln Leu Thr Lys Arg 
        675                 680                 685             


Ile Glu Asp Tyr Lys Thr Thr Ala Pro His Val Glu Val Ala Lys Lys 
    690                 695                 700                 


Ile Leu Lys Ser Gly Asn Arg Val Asn Thr Gly Asp Val Ile Ser Tyr 
705                 710                 715                 720 


Ile Ile Thr Ser Gly Asn Lys Ser Ile Ser Glu Arg Ala Glu Ile Leu 
                725                 730                 735     


Glu Asn Ala Lys Asn Tyr Asp Thr Asn Tyr Tyr Ile Glu Asn Gln Ile 
            740                 745                 750         


Leu Pro Pro Val Ile Arg Leu Met Glu Ala Leu Gly Ile Thr Lys Asp 
        755                 760                 765             


Glu Leu Lys Asp Ser Lys Lys Gln Tyr Thr Leu His His Phe Leu Lys 
    770                 775                 780                 


<210>  23
<211>  784
<212>  PRT
<213>  Methanococcus maripaludis


<220>
<221>  MISC_FEATURE
<222>  (1)..(784)
<223>  exo_ L417P/Y418A/S420T mutant

<400>  23

Met Glu Ser Leu Ile Asp Leu Asp Tyr Asn Ser Asp Asp Leu Cys Ile 
1               5                   10                  15      


Tyr Leu Tyr Leu Ile Asn Ser Ile Ile Lys Glu Lys Asp Phe Lys Pro 
            20                  25                  30          


Tyr Phe Tyr Val Asn Ser Thr Asp Lys Glu Gln Ile Leu Glu Phe Leu 
        35                  40                  45              


Lys Asp Tyr Glu Lys Lys His Lys Leu Asp Ser Glu Ile Ser Lys Met 
    50                  55                  60                  


Ile Glu Asn Ile Glu Thr Val Lys Lys Ile Val Phe Asp Glu Asn Tyr 
65                  70                  75                  80  


Gln Glu Lys Glu Leu Ser Lys Val Thr Val Lys Tyr Pro Asn Asn Val 
                85                  90                  95      


Lys Thr Val Arg Glu Ile Leu Met Glu Phe Glu Arg Leu Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Val Arg Arg Tyr Leu Ile Asp Asn Ser Val Ile Pro 
        115                 120                 125             


Thr Ser Thr Trp Asp Phe Glu Asn Asn Lys Lys Ile Asp Asn Lys Ile 
    130                 135                 140                 


Pro Asp Phe Lys Thr Val Ser Phe Ala Ile Ala Val Tyr Cys Asn Lys 
145                 150                 155                 160 


Glu Pro Asn Pro Lys Lys Asp Pro Ile Ile Met Ala Ser Phe Ser Ser 
                165                 170                 175     


Lys Asp Phe Asn Thr Val Val Ser Thr Lys Lys Phe Asp His Glu Lys 
            180                 185                 190         


Leu Glu Tyr Val Lys Asp Glu Lys Glu Leu Ile Lys Arg Ile Ile Glu 
        195                 200                 205             


Ile Leu Lys Glu Tyr Asp Ile Ile Tyr Thr Tyr Asn Gly Asp Asn Phe 
    210                 215                 220                 


Asp Phe Pro Tyr Leu Lys Lys Arg Ala Glu Ser Phe Gly Leu Glu Leu 
225                 230                 235                 240 


Lys Leu Gly Lys Asn Asp Glu Lys Ile Lys Ile Thr Lys Gly Gly Met 
                245                 250                 255     


Asn Ser Lys Ser Tyr Ile Pro Gly Arg Val His Ile Asp Leu Tyr Pro 
            260                 265                 270         


Ile Ala Arg Arg Leu Leu Asn Leu Thr Lys Tyr Arg Leu Glu Asn Val 
        275                 280                 285             


Thr Glu Ala Leu Phe Asp Val Lys Lys Val Asp Val Gly His Glu Asn 
    290                 295                 300                 


Ile Pro Lys Met Trp Asp Asn Leu Asp Glu Thr Leu Val Glu Tyr Ser 
305                 310                 315                 320 


His Gln Asp Ala Tyr Tyr Thr Gln Arg Ile Gly Glu Gln Phe Leu Pro 
                325                 330                 335     


Leu Glu Ile Met Phe Ser Arg Val Val Asn Gln Ser Leu Tyr Asp Ile 
            340                 345                 350         


Asn Arg Met Ser Ser Ser Gln Met Val Glu Tyr Leu Leu Leu Lys Asn 
        355                 360                 365             


Ser Tyr Lys Met Gly Val Ile Ala Pro Asn Arg Pro Ser Gly Lys Glu 
    370                 375                 380                 


Tyr Gln Lys Arg Ile Arg Ser Ser Tyr Glu Gly Gly Tyr Val Lys Glu 
385                 390                 395                 400 


Pro Leu Lys Gly Ile His Glu Asp Ile Val Ser Met Asp Phe Leu Ser 
                405                 410                 415     


Pro Ala Pro Thr Ile Ile Met Ser His Asn Leu Ser Pro Glu Thr Ile 
            420                 425                 430         


Asp Cys Thr Cys Cys Ser Asp Glu Glu Asn Gly Glu Asn Glu Glu Ile 
        435                 440                 445             


Leu Gly His Lys Phe Cys Lys Lys Ser Ile Gly Ile Ile Pro Lys Thr 
    450                 455                 460                 


Leu Met Asp Leu Ile Asn Arg Arg Lys Lys Val Lys Lys Val Leu Arg 
465                 470                 475                 480 


Glu Lys Ala Glu Lys Gly Glu Phe Asp Glu Glu Tyr Gln Ile Leu Asp 
                485                 490                 495     


Tyr Glu Gln Arg Ser Ile Lys Val Leu Ala Asn Ser His Tyr Gly Tyr 
            500                 505                 510         


Leu Ala Phe Pro Met Ala Arg Trp Tyr Ser Arg Asp Cys Ala Glu Ile 
        515                 520                 525             


Thr Thr His Leu Gly Arg Gln Tyr Ile Gln Lys Thr Ile Glu Glu Ala 
    530                 535                 540                 


Glu Asn Phe Gly Phe Lys Val Ile Tyr Ala Asp Thr Asp Gly Phe Tyr 
545                 550                 555                 560 


Ser Lys Trp Ala Asp Asp Lys Glu Lys Leu Ser Lys Tyr Glu Leu Leu 
                565                 570                 575     


Glu Lys Thr Arg Glu Phe Leu Lys Asn Ile Asn Asn Thr Leu Pro Gly 
            580                 585                 590         


Glu Met Glu Leu Glu Phe Glu Gly Tyr Phe Lys Arg Gly Ile Phe Val 
        595                 600                 605             


Thr Lys Lys Lys Tyr Ala Leu Ile Asp Glu Asn Glu Lys Ile Thr Val 
    610                 615                 620                 


Lys Gly Leu Glu Val Val Arg Arg Asp Trp Ser Asn Val Ser Lys Asn 
625                 630                 635                 640 


Thr Gln Lys Asn Val Leu Asn Ala Leu Leu Lys Glu Gly Ser Val Glu 
                645                 650                 655     


Asn Ala Lys Lys Val Ile Gln Asp Thr Ile Lys Glu Leu Lys Asp Gly 
            660                 665                 670         


Lys Val Asn Asn Glu Asp Leu Leu Ile His Thr Gln Leu Thr Lys Arg 
        675                 680                 685             


Ile Glu Asp Tyr Lys Thr Thr Ala Pro His Val Glu Val Ala Lys Lys 
    690                 695                 700                 


Ile Leu Lys Ser Gly Asn Arg Val Asn Thr Gly Asp Val Ile Ser Tyr 
705                 710                 715                 720 


Ile Ile Thr Ser Gly Asn Lys Ser Ile Ser Glu Arg Ala Glu Ile Leu 
                725                 730                 735     


Glu Asn Ala Lys Asn Tyr Asp Thr Asn Tyr Tyr Ile Glu Asn Gln Ile 
            740                 745                 750         


Leu Pro Pro Val Ile Arg Leu Met Glu Ala Leu Gly Ile Thr Lys Asp 
        755                 760                 765             


Glu Leu Lys Asp Ser Lys Lys Gln Tyr Thr Leu His His Phe Leu Lys 
    770                 775                 780                 


