
                                SEQUENCE LISTING

<110> Innovative Targeting Solutions Inc.
	Gallo, Michael
	Kang, Jaspal Singh
	Pigott, Craig Robin

<120> SEQUENCE DIVERSITY GENERATION IN
	IMMUNOGLOBULINS   

<130> 520056.403PC

<140> PCT                  
<141> 2009-04-14  

<160> 109

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 3206
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized sequence for translation into
      mammalian cells.

<400> 1
ggcgcgccaa gcttgcggcc gcggtaccgc tagcgccgcc accatggccg ccagcttccc 60
ccctaccctg ggcctgagca gcgcccctga cgagatccag cacccccaca tcaagttcag 120
cgagtggaag ttcaagctgt tcagagtgcg gagcttcgaa aagacccccg aggaggccca 180
gaaggagaag aaggacagct tcgagggcaa gcccagcctg gagcagagcc ctgccgtgct 240
ggacaaggcc gacggccaga agcccgtccc cacccagccc ctgctgaagg cccaccccaa 300
gttcagcaag aagttccacg acaacgagaa ggccaggggc aaggccatcc accaggccaa 360
cctgcggcac ctgtgccgga tctgcggcaa cagcttccgg gccgacgagc acaaccggcg 420
ctaccccgtg cacggccccg tggacggcaa gaccctggga ctgctgcgga agaaggagaa 480
gcgggccacc tcctggcccg acctgatcgc caaggtgttc aggatcgacg tgaaggccga 540
cgtggacagc atccacccca ccgagttctg ccacaactgc tggtccatca tgcaccggaa 600
gttcagctcc gccccctgcg aggtgtactt cccccggaac gtgaccatgg agtggcaccc 660
tcacaccccc agctgcgaca tctgcaacac cgccagacgg ggcctgaagc ggaagtccct 720
gcagcccaac ctgcagctgt ccaagaagct gaaaaccgtc ctggatcagg cccggcaggc 780
caggcagaga aagcggagag cccaggcccg gatcagcagc aaggacgtga tgaagaagat 840
cgccaactgc agcaagatcc acctgagcac caagctgctg gccgtggact tccccgagca 900
cttcgtgaag tccatcagct gccagatctg cgagcacatc ctggccgacc ccgtggagac 960
aaactgcaag cacgtgttct gcagagtgtg catcctgcgg tgcctgaagg tgatgggcag 1020
ctactgcccc agctgcagat acccctgctt ccccaccgac ctggagagcc ccgtgaagtc 1080
cttcctgagc gtgctgaaca gcctgatggt gaagtgcccc gccaaggagt gcaacgagga 1140
ggtctccctg gagaagtaca accaccacat cagcagccac aaggagagca aggagatctt 1200
cgtccacatc aacaagggcg gcagaccccg gcagcacctg ctgtccctga ccagacgggc 1260
ccagaagcac agactgcggg agctgaagct gcaggtgaag gccttcgccg acaaggagga 1320
gggcggcgac gtcaagtccg tgtgcatgac cctgtttctg ctggccctga gagctaggaa 1380
cgagcaccgg caggccgatg agctggaggc catcatgcag ggcaagggca gcggcctgca 1440
gcctgccgtg tgcctggcca tcagagtgaa cacctttctg agctgcagcc agtaccacaa 1500
gatgtaccgg accgtgaagg ccatcaccgg cagacagatc ttccagcctc tgcacgccct 1560
gcggaacgcc gagaaggtgc tgctgcccgg ctaccaccac ttcgagtggc agccccccct 1620
gaagaacgtg tccagcagca ccgacgtggg catcatcgac ggcctgagcg gcctgtccag 1680
ctccgtggac gactaccctg tggacacaat cgccaagcgg ttcagatacg acagcgccct 1740
ggtgtccgcc ctgatggaca tggaggagga catcctggag ggcatgcgga gccaggacct 1800
ggacgattac ctgaacggcc ccttcaccgt ggtggtgaaa gaatcctgcg acggcatggg 1860
cgacgtgtcc gagaagcacg gcagcggccc tgtggtgccc gagaaggccg tgcggttcag 1920
cttcaccatc atgaagatca caatcgccca cagcagccag aacgtgaagg tgttcgagga 1980
ggccaagccc aacagcgagc tgtgctgcaa gcccctgtgc ctgatgctgg ccgacgagag 2040
cgaccacgag acactgaccg ccatcctgag ccccctgatc gccgagcggg aggccatgaa 2100
gtcctccgag ctgatgctgg agctgggcgg catcctgagg accttcaagt tcatcttccg 2160
gggcaccggc tacgacgaga agctggtgcg ggaggtggag ggcctggagg ccagcggcag 2220
cgtgtacatc tgcaccctgt gcgacgccac ccggctggag gcctcccaga acctggtgtt 2280
ccacagcatc acccggtccc acgccgagaa cctggagaga tacgaggtgt ggcggagcaa 2340
cccctaccac gagagcgtgg aggagctgcg ggacagagtg aagggcgtga gcgccaagcc 2400
cttcatcgag acagtgccca gcatcgacgc cctgcactgc gatatcggca acgccgccga 2460
gttctacaag atctttcagc tggagatcgg agaggtgtac aagaacccca acgccagcaa 2520
ggaggagcgg aagcgctggc aggccaccct ggacaagcac ctgcgcaaga agatgaacct 2580
gaagcccatc atgcggatga acggcaactt cgccagaaag ctgatgacca aggaaacagt 2640
ggacgccgtc tgcgagctga tccccagcga ggagcggcac gaggccctgc gcgagctgat 2700
ggacctgtac ctgaagatga agcccgtgtg gcggtccagc tgtcctgcca aggagtgtcc 2760
cgagagcctg tgccagtaca gcttcaacag ccagcggttc gccgagctgc tgtccaccaa 2820
gttcaagtac cgctacgagg gcaagatcac caactacttc cacaagacac tggcccacgt 2880
gcccgagatc atcgagcggg acggcagcat cggcgcctgg gccagcgagg gcaacgagag 2940
cggcaacaag ctgttccggc ggttcaggaa gatgaacgcc aggcagagca agtgctacga 3000
gatggaggac gtgctgaagc accactggct gtacaccagc aagtacctgc agaaattcat 3060
gaacgcccac aacgccctga aaaccagcgg cttcaccatg aaccctcagg ccagcctggg 3120
cgaccctctg ggcatcgagg actccctgga gtcccaggac agcatggaat tctgataatc 3180
tagagcggcc gcggatcctt aattaa                                      3206

<210> 2
<211> 1043
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Ala Ser Phe Pro Pro Thr Leu Gly Leu Ser Ser Ala Pro Asp
 1               5                  10                  15      
Glu Ile Gln His Pro His Ile Lys Phe Ser Glu Trp Lys Phe Lys Leu
            20                  25                  30          
Phe Arg Val Arg Ser Phe Glu Lys Thr Pro Glu Glu Ala Gln Lys Glu
        35                  40                  45              
Lys Lys Asp Ser Phe Glu Gly Lys Pro Ser Leu Glu Gln Ser Pro Ala
    50                  55                  60                  
Val Leu Asp Lys Ala Asp Gly Gln Lys Pro Val Pro Thr Gln Pro Leu
65                  70                  75                  80  
Leu Lys Ala His Pro Lys Phe Ser Lys Lys Phe His Asp Asn Glu Lys
                85                  90                  95      
Ala Arg Gly Lys Ala Ile His Gln Ala Asn Leu Arg His Leu Cys Arg
            100                 105                 110         
Ile Cys Gly Asn Ser Phe Arg Ala Asp Glu His Asn Arg Arg Tyr Pro
        115                 120                 125             
Val His Gly Pro Val Asp Gly Lys Thr Leu Gly Leu Leu Arg Lys Lys
    130                 135                 140                 
Glu Lys Arg Ala Thr Ser Trp Pro Asp Leu Ile Ala Lys Val Phe Arg
145                 150                 155                 160 
Ile Asp Val Lys Ala Asp Val Asp Ser Ile His Pro Thr Glu Phe Cys
                165                 170                 175     
His Asn Cys Trp Ser Ile Met His Arg Lys Phe Ser Ser Ala Pro Cys
            180                 185                 190         
Glu Val Tyr Phe Pro Arg Asn Val Thr Met Glu Trp His Pro His Thr
        195                 200                 205             
Pro Ser Cys Asp Ile Cys Asn Thr Ala Arg Arg Gly Leu Lys Arg Lys
    210                 215                 220                 
Ser Leu Gln Pro Asn Leu Gln Leu Ser Lys Lys Leu Lys Thr Val Leu
225                 230                 235                 240 
Asp Gln Ala Arg Gln Ala Arg Gln Arg Lys Arg Arg Ala Gln Ala Arg
                245                 250                 255     
Ile Ser Ser Lys Asp Val Met Lys Lys Ile Ala Asn Cys Ser Lys Ile
            260                 265                 270         
His Leu Ser Thr Lys Leu Leu Ala Val Asp Phe Pro Glu His Phe Val
        275                 280                 285             
Lys Ser Ile Ser Cys Gln Ile Cys Glu His Ile Leu Ala Asp Pro Val
    290                 295                 300                 
Glu Thr Asn Cys Lys His Val Phe Cys Arg Val Cys Ile Leu Arg Cys
305                 310                 315                 320 
Leu Lys Val Met Gly Ser Tyr Cys Pro Ser Cys Arg Tyr Pro Cys Phe
                325                 330                 335     
Pro Thr Asp Leu Glu Ser Pro Val Lys Ser Phe Leu Ser Val Leu Asn
            340                 345                 350         
Ser Leu Met Val Lys Cys Pro Ala Lys Glu Cys Asn Glu Glu Val Ser
        355                 360                 365             
Leu Glu Lys Tyr Asn His His Ile Ser Ser His Lys Glu Ser Lys Glu
    370                 375                 380                 
Ile Phe Val His Ile Asn Lys Gly Gly Arg Pro Arg Gln His Leu Leu
385                 390                 395                 400 
Ser Leu Thr Arg Arg Ala Gln Lys His Arg Leu Arg Glu Leu Lys Leu
                405                 410                 415     
Gln Val Lys Ala Phe Ala Asp Lys Glu Glu Gly Gly Asp Val Lys Ser
            420                 425                 430         
Val Cys Met Thr Leu Phe Leu Leu Ala Leu Arg Ala Arg Asn Glu His
        435                 440                 445             
Arg Gln Ala Asp Glu Leu Glu Ala Ile Met Gln Gly Lys Gly Ser Gly
    450                 455                 460                 
Leu Gln Pro Ala Val Cys Leu Ala Ile Arg Val Asn Thr Phe Leu Ser
465                 470                 475                 480 
Cys Ser Gln Tyr His Lys Met Tyr Arg Thr Val Lys Ala Ile Thr Gly
                485                 490                 495     
Arg Gln Ile Phe Gln Pro Leu His Ala Leu Arg Asn Ala Glu Lys Val
            500                 505                 510         
Leu Leu Pro Gly Tyr His His Phe Glu Trp Gln Pro Pro Leu Lys Asn
        515                 520                 525             
Val Ser Ser Ser Thr Asp Val Gly Ile Ile Asp Gly Leu Ser Gly Leu
    530                 535                 540                 
Ser Ser Ser Val Asp Asp Tyr Pro Val Asp Thr Ile Ala Lys Arg Phe
545                 550                 555                 560 
Arg Tyr Asp Ser Ala Leu Val Ser Ala Leu Met Asp Met Glu Glu Asp
                565                 570                 575     
Ile Leu Glu Gly Met Arg Ser Gln Asp Leu Asp Asp Tyr Leu Asn Gly
            580                 585                 590         
Pro Phe Thr Val Val Val Lys Glu Ser Cys Asp Gly Met Gly Asp Val
        595                 600                 605             
Ser Glu Lys His Gly Ser Gly Pro Val Val Pro Glu Lys Ala Val Arg
    610                 615                 620                 
Phe Ser Phe Thr Ile Met Lys Ile Thr Ile Ala His Ser Ser Gln Asn
625                 630                 635                 640 
Val Lys Val Phe Glu Glu Ala Lys Pro Asn Ser Glu Leu Cys Cys Lys
                645                 650                 655     
Pro Leu Cys Leu Met Leu Ala Asp Glu Ser Asp His Glu Thr Leu Thr
            660                 665                 670         
Ala Ile Leu Ser Pro Leu Ile Ala Glu Arg Glu Ala Met Lys Ser Ser
        675                 680                 685             
Glu Leu Met Leu Glu Leu Gly Gly Ile Leu Arg Thr Phe Lys Phe Ile
    690                 695                 700                 
Phe Arg Gly Thr Gly Tyr Asp Glu Lys Leu Val Arg Glu Val Glu Gly
705                 710                 715                 720 
Leu Glu Ala Ser Gly Ser Val Tyr Ile Cys Thr Leu Cys Asp Ala Thr
                725                 730                 735     
Arg Leu Glu Ala Ser Gln Asn Leu Val Phe His Ser Ile Thr Arg Ser
            740                 745                 750         
His Ala Glu Asn Leu Glu Arg Tyr Glu Val Trp Arg Ser Asn Pro Tyr
        755                 760                 765             
His Glu Ser Val Glu Glu Leu Arg Asp Arg Val Lys Gly Val Ser Ala
    770                 775                 780                 
Lys Pro Phe Ile Glu Thr Val Pro Ser Ile Asp Ala Leu His Cys Asp
785                 790                 795                 800 
Ile Gly Asn Ala Ala Glu Phe Tyr Lys Ile Phe Gln Leu Glu Ile Gly
                805                 810                 815     
Glu Val Tyr Lys Asn Pro Asn Ala Ser Lys Glu Glu Arg Lys Arg Trp
            820                 825                 830         
Gln Ala Thr Leu Asp Lys His Leu Arg Lys Lys Met Asn Leu Lys Pro
        835                 840                 845             
Ile Met Arg Met Asn Gly Asn Phe Ala Arg Lys Leu Met Thr Lys Glu
    850                 855                 860                 
Thr Val Asp Ala Val Cys Glu Leu Ile Pro Ser Glu Glu Arg His Glu
865                 870                 875                 880 
Ala Leu Arg Glu Leu Met Asp Leu Tyr Leu Lys Met Lys Pro Val Trp
                885                 890                 895     
Arg Ser Ser Cys Pro Ala Lys Glu Cys Pro Glu Ser Leu Cys Gln Tyr
            900                 905                 910         
Ser Phe Asn Ser Gln Arg Phe Ala Glu Leu Leu Ser Thr Lys Phe Lys
        915                 920                 925             
Tyr Arg Tyr Glu Gly Lys Ile Thr Asn Tyr Phe His Lys Thr Leu Ala
    930                 935                 940                 
His Val Pro Glu Ile Ile Glu Arg Asp Gly Ser Ile Gly Ala Trp Ala
945                 950                 955                 960 
Ser Glu Gly Asn Glu Ser Gly Asn Lys Leu Phe Arg Arg Phe Arg Lys
                965                 970                 975     
Met Asn Ala Arg Gln Ser Lys Cys Tyr Glu Met Glu Asp Val Leu Lys
            980                 985                 990         
His His Trp Leu Tyr Thr Ser Lys Tyr Leu Gln Lys Phe Met Asn Ala
        995                 1000                1005            
His Asn Ala Leu Lys Thr Ser Gly Phe Thr Met Asn Pro Gln Ala Ser
    1010                1015                1020                
Leu Gly Asp Pro Leu Gly Ile Glu Asp Ser Leu Glu Ser Gln Asp Ser
1025                1030                1035               1040 
Met Glu Phe
            


<210> 3
<211> 1661
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized sequence for translation into
      mammalian cells.

<400> 3
ggcgcgccga attcgcggcc gcggtaccgc tagcaagctt gccgccacca tgagcctgca 60
gatggtgacc gtgtccaaca atatcgccct gatccagccc ggcttcagcc tgatgaactt 120
cgacggccag gtgttcttct tcggccagaa gggctggccc aagcggagct gccccaccgg 180
cgtgttccac ctggacgtga agcacaacca cgtgaagctg aagcctacca tcttcagcaa 240
ggacagctgc tacctgcccc ccctgcgcta ccctgccacc tgcaccttca agggcagcct 300
ggagagcgag aagcaccagt acatcatcca cggcggcaag acacccaaca acgaggtgtc 360
cgacaagatc tacgtgatga gcatcgtgtg caagaacaac aagaaggtga ccttccgctg 420
caccgagaag gacctggtgg gagatgtgcc cgaggccaga tacggccact ccatcaacgt 480
ggtgtacagc cggggcaaga gcatgggcgt gctgttcggc ggcaggtcct acatgcccag 540
cacccaccgg accaccgaga agtggaacag cgtggccgac tgcctgccct gcgtgttcct 600
ggtggacttc gagttcggct gcgccacctc ctacatcctg ccagagctgc aggacggcct 660
gtccttccac gtgtctatcg ccaagaacga caccatctac atcctgggcg gccacagcct 720
ggccaacaac atcaggcccg ccaacctgta ccggatcagg gtggacctgc ccctgggcag 780
cccagccgtg aactgcaccg tgctgcctgg cggcatcagc gtgtcctctg ccatcctgac 840
ccagaccaac aacgacgagt tcgtgatcgt gggcggctac cagctggaga accagaaacg 900
gatgatctgc aacatcatca gcctggagga caacaagatc gagatccggg agatggagac 960
acccgactgg acccctgaca tcaagcacag caagatctgg ttcggcagca acatgggcaa 1020
cggcaccgtg tttctgggca tccccggcga caacaagcag gtggtgtccg agggcttcta 1080
cttctacatg ctgaagtgcg ccgaggacga caccaacgag gagcagacca ccttcaccaa 1140
cagccagacc agcaccgagg accccggcga ctccaccccc ttcgaggaca gcgaggagtt 1200
ttgcttcagc gccgaggcca acagcttcga cggcgacgac gagtttgaca cctacaacga 1260
ggacgacgag gaggacgagt ccgagacagg ctactggatc acctgctgcc ctacctgcga 1320
cgtggatatc aacacctggg tgcccttcta cagcaccgag ctgaacaagc ccgccatgat 1380
ctactgcagc cacggcgacg gccactgggt gcacgcccag tgcatggacc tggccgagcg 1440
gaccctgatc cacctgtccg ccggctccaa caagtactac tgcaacgagc acgtggagat 1500
cgccagggcc ctgcacaccc cccagagagt gctgcctctg aaaaagcccc ctatgaagtc 1560
cctgaggaag aagggctccg gcaagatcct gacccccgcc aagaagtcct ttctgcggcg 1620
gctgttcgac tgagcggccg ctctagactc gagttaatta a                     1661

<210> 4
<211> 527
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Leu Gln Met Val Thr Val Ser Asn Asn Ile Ala Leu Ile Gln
 1               5                  10                  15      
Pro Gly Phe Ser Leu Met Asn Phe Asp Gly Gln Val Phe Phe Phe Gly
            20                  25                  30          
Gln Lys Gly Trp Pro Lys Arg Ser Cys Pro Thr Gly Val Phe His Leu
        35                  40                  45              
Asp Val Lys His Asn His Val Lys Leu Lys Pro Thr Ile Phe Ser Lys
    50                  55                  60                  
Asp Ser Cys Tyr Leu Pro Pro Leu Arg Tyr Pro Ala Thr Cys Thr Phe
65                  70                  75                  80  
Lys Gly Ser Leu Glu Ser Glu Lys His Gln Tyr Ile Ile His Gly Gly
                85                  90                  95      
Lys Thr Pro Asn Asn Glu Val Ser Asp Lys Ile Tyr Val Met Ser Ile
            100                 105                 110         
Val Cys Lys Asn Asn Lys Lys Val Thr Phe Arg Cys Thr Glu Lys Asp
        115                 120                 125             
Leu Val Gly Asp Val Pro Glu Ala Arg Tyr Gly His Ser Ile Asn Val
    130                 135                 140                 
Val Tyr Ser Arg Gly Lys Ser Met Gly Val Leu Phe Gly Gly Arg Ser
145                 150                 155                 160 
Tyr Met Pro Ser Thr His Arg Thr Thr Glu Lys Trp Asn Ser Val Ala
                165                 170                 175     
Asp Cys Leu Pro Cys Val Phe Leu Val Asp Phe Glu Phe Gly Cys Ala
            180                 185                 190         
Thr Ser Tyr Ile Leu Pro Glu Leu Gln Asp Gly Leu Ser Phe His Val
        195                 200                 205             
Ser Ile Ala Lys Asn Asp Thr Ile Tyr Ile Leu Gly Gly His Ser Leu
    210                 215                 220                 
Ala Asn Asn Ile Arg Pro Ala Asn Leu Tyr Arg Ile Arg Val Asp Leu
225                 230                 235                 240 
Pro Leu Gly Ser Pro Ala Val Asn Cys Thr Val Leu Pro Gly Gly Ile
                245                 250                 255     
Ser Val Ser Ser Ala Ile Leu Thr Gln Thr Asn Asn Asp Glu Phe Val
            260                 265                 270         
Ile Val Gly Gly Tyr Gln Leu Glu Asn Gln Lys Arg Met Ile Cys Asn
        275                 280                 285             
Ile Ile Ser Leu Glu Asp Asn Lys Ile Glu Ile Arg Glu Met Glu Thr
    290                 295                 300                 
Pro Asp Trp Thr Pro Asp Ile Lys His Ser Lys Ile Trp Phe Gly Ser
305                 310                 315                 320 
Asn Met Gly Asn Gly Thr Val Phe Leu Gly Ile Pro Gly Asp Asn Lys
                325                 330                 335     
Gln Val Val Ser Glu Gly Phe Tyr Phe Tyr Met Leu Lys Cys Ala Glu
            340                 345                 350         
Asp Asp Thr Asn Glu Glu Gln Thr Thr Phe Thr Asn Ser Gln Thr Ser
        355                 360                 365             
Thr Glu Asp Pro Gly Asp Ser Thr Pro Phe Glu Asp Ser Glu Glu Phe
    370                 375                 380                 
Cys Phe Ser Ala Glu Ala Asn Ser Phe Asp Gly Asp Asp Glu Phe Asp
385                 390                 395                 400 
Thr Tyr Asn Glu Asp Asp Glu Glu Asp Glu Ser Glu Thr Gly Tyr Trp
                405                 410                 415     
Ile Thr Cys Cys Pro Thr Cys Asp Val Asp Ile Asn Thr Trp Val Pro
            420                 425                 430         
Phe Tyr Ser Thr Glu Leu Asn Lys Pro Ala Met Ile Tyr Cys Ser His
        435                 440                 445             
Gly Asp Gly His Trp Val His Ala Gln Cys Met Asp Leu Ala Glu Arg
    450                 455                 460                 
Thr Leu Ile His Leu Ser Ala Gly Ser Asn Lys Tyr Tyr Cys Asn Glu
465                 470                 475                 480 
His Val Glu Ile Ala Arg Ala Leu His Thr Pro Gln Arg Val Leu Pro
                485                 490                 495     
Leu Lys Lys Pro Pro Met Lys Ser Leu Arg Lys Lys Gly Ser Gly Lys
            500                 505                 510         
Ile Leu Thr Pro Ala Lys Lys Ser Phe Leu Arg Arg Leu Phe Asp
        515                 520                 525         


<210> 5
<211> 1551
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized sequence for translation into
      mammalian cells.

<400> 5
aagcttgccg ccaccatgga cccccccaga gccagccacc tgagccccag aaagaagaga 60
cccagacaga ccggcgccct gatggccagc agcccccagg acatcaagtt ccaggacctg 120
gtggtgttca tcctggagaa gaagatgggc accaccagaa gagccttcct gatggagctg 180
gccagaagaa agggcttcag agtggagaac gagctgagcg acagcgtgac ccacatcgtg 240
gccgagaaca acagcggcag cgacgtgctc gagtggctgc aggcccagaa ggtgcaggtg 300
agcagccagc ccgagctgct ggacgtgagc tggctgatcg agtgcatcag agccggcaag 360
cccgtggaga tgaccggcaa gcaccagctg gtggtgagaa gagactacag cgacagcacc 420
aaccccggcc cccccaagac cccccccatc gccgtgcaga agatcagcca gtacgcctgc 480
cagagaagaa ccaccctgaa caactgcaac cagattttca ccgacgcctt cgacatcctg 540
gccgagaact gcgagttcag agagaacgag gacagctgcg tgaccttcat gagagccgcc 600
agcgtgctga agagcctgcc cttcaccatc atcagcatga aggacaccga gggcatcccc 660
tgcctgggca gcaaggtgaa gggcatcatc gaggagatca tcgaggacgg cgagagcagc 720
gaggtgaagg ccgtgctgaa cgacgagaga taccagagct tcaagctgtt caccagcgtg 780
ttcggcgtgg gcctgaagac cagcgagaag tggttcagaa tgggcttcag aaccctgagc 840
aaggtgagaa gcgacaagag ccttaagttc accagaatgc agaaggccgg cttcctgtac 900
tacgaagatc tggtgagctg cgtgaccaga gccgaggccg aggccgtgag cgtgctggtg 960
aaggaggccg tgtgggcctt cctgcccgac gccttcgtga ccatgaccgg cggcttcaga 1020
agaggcaaga agatgggcca cgacgtggac ttcctgatca ccagccccgg cagcaccgag 1080
gacgaggagc agctgctgca gaaggtgatg aacctgtggg agaagaaggg cctgctgctg 1140
tactacgacc tggtggagag caccttcgag aagctgagac tgcccagcag aaaggtggac 1200
gccctggacc acttccagaa gtgcttcctg atcttcaagc tgcccagaca gagagtggac 1260
agcgaccaga gcagctggca ggagggcaag acctggaagg ccatcagagt ggacctggtg 1320
ctgtgcccct acgagagaag agccttcgcc ctgctgggct ggaccggcag cagacagttc 1380
gagagagacc tgagaagata cgccacccac gagagaaaga tgatcctgga caaccacgcc 1440
ctgtacgaca agaccaagag aatcttcctg aaggccgaga gcgaggagga aatcttcgcc 1500
cacctgggcc tggactacat cgagccctgg gagagaaacg cctgatctag a          1551

<210> 6
<211> 509
<212> PRT
<213> Homo sapiens

<400> 6
Met Asp Pro Pro Arg Ala Ser His Leu Ser Pro Arg Lys Lys Arg Pro
 1               5                  10                  15      
Arg Gln Thr Gly Ala Leu Met Ala Ser Ser Pro Gln Asp Ile Lys Phe
            20                  25                  30          
Gln Asp Leu Val Val Phe Ile Leu Glu Lys Lys Met Gly Thr Thr Arg
        35                  40                  45              
Arg Ala Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu
    50                  55                  60                  
Asn Glu Leu Ser Asp Ser Val Thr His Ile Val Ala Glu Asn Asn Ser
65                  70                  75                  80  
Gly Ser Asp Val Leu Glu Trp Leu Gln Ala Gln Lys Val Gln Val Ser
                85                  90                  95      
Ser Gln Pro Glu Leu Leu Asp Val Ser Trp Leu Ile Glu Cys Ile Arg
            100                 105                 110         
Ala Gly Lys Pro Val Glu Met Thr Gly Lys His Gln Leu Val Val Arg
        115                 120                 125             
Arg Asp Tyr Ser Asp Ser Thr Asn Pro Gly Pro Pro Lys Thr Pro Pro
    130                 135                 140                 
Ile Ala Val Gln Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr
145                 150                 155                 160 
Leu Asn Asn Cys Asn Gln Ile Phe Thr Asp Ala Phe Asp Ile Leu Ala
                165                 170                 175     
Glu Asn Cys Glu Phe Arg Glu Asn Glu Asp Ser Cys Val Thr Phe Met
            180                 185                 190         
Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Thr Ile Ile Ser Met
        195                 200                 205             
Lys Asp Thr Glu Gly Ile Pro Cys Leu Gly Ser Lys Val Lys Gly Ile
    210                 215                 220                 
Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys Ala Val
225                 230                 235                 240 
Leu Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe
                245                 250                 255     
Gly Val Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg
            260                 265                 270         
Thr Leu Ser Lys Val Arg Ser Asp Lys Ser Leu Lys Phe Thr Arg Met
        275                 280                 285             
Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr
    290                 295                 300                 
Arg Ala Glu Ala Glu Ala Val Ser Val Leu Val Lys Glu Ala Val Trp
305                 310                 315                 320 
Ala Phe Leu Pro Asp Ala Phe Val Thr Met Thr Gly Gly Phe Arg Arg
                325                 330                 335     
Gly Lys Lys Met Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly
            340                 345                 350         
Ser Thr Glu Asp Glu Glu Gln Leu Leu Gln Lys Val Met Asn Leu Trp
        355                 360                 365             
Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe
    370                 375                 380                 
Glu Lys Leu Arg Leu Pro Ser Arg Lys Val Asp Ala Leu Asp His Phe
385                 390                 395                 400 
Gln Lys Cys Phe Leu Ile Phe Lys Leu Pro Arg Gln Arg Val Asp Ser
                405                 410                 415     
Asp Gln Ser Ser Trp Gln Glu Gly Lys Thr Trp Lys Ala Ile Arg Val
            420                 425                 430         
Asp Leu Val Leu Cys Pro Tyr Glu Arg Arg Ala Phe Ala Leu Leu Gly
        435                 440                 445             
Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala Thr
    450                 455                 460                 
His Glu Arg Lys Met Ile Leu Asp Asn His Ala Leu Tyr Asp Lys Thr
465                 470                 475                 480 
Lys Arg Ile Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile Phe Ala His
                485                 490                 495     
Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala
            500                 505                 


<210> 7
<211> 3385
<212> DNA
<213> Artificial Sequence

<220> 
<223> LacZ recombination signal sequence

<400> 7
ttaattaagc ttctgcacct cgaagggtac ctactgtgcg agagacacag tgctccaggg 60
ctgaacaaaa accgaattct cacttctggc accacaccag ctgatagtgg tatctgccgg 120
cggacagctg aaactcggcg gacacgctgg gggaccagct gtcgtcgccg ccgatgccca 180
tgtggaagcc gtcgatgttc agccaggtgc cctcctcggc gtgcagcagg tgccggtggc 240
ttgtctccat cagctgctgc tgagagtacc ggctgatgtt gaactggaag tcgcccctcc 300
actggtgggg gccgtagttc agctcccggg tgccgcatct caggccattc tcgctgggga 360
acacgtaggg ggtgtacatg tcgctcagag gcaggtccca tctgtcgaag caggcggcgg 420
tcagccggtc ggggtagttc tcctgggggc ccaggcccag ccagttcact ctctcggcca 480
cctgggccag ctgacagttc aggccgattc tggcggggtg aggggtgtcg gaggccacct 540
ccacgtccac tgtgatggcc atctggccgc tgccgtcgat ccggtaggtc tttctggaga 600
tgaacagtgt cttgccctgg tgctgccaag cgtgggcggt ggtgatcagc acggcgtcgg 660
ccagggtatc ggcggtgcac tgcagcaggg cggcctcggc ctggtagtgt ccggcagcct 720
tccaccgctc cacccaggcg ttggggtcga tccgggtggc ctcgctcacg ccgatgtcgt 780
tgtccagggg ggctctggtg aactggtccc gcaggggggt cagcagctgc ttcttgtcgc 840
cgatccacat ctgggacagg aagccgctct gccggttgaa ctgccaccgc ttgttgccca 900
gctcgatgca aaagtccatc tcggaggtgg tcaggtgggg gatggcgtgg ctggcggcag 960
gcagggtcac ggacaggttc tcggccagcc gccactgctg ccaggcgctg atgtggccgg 1020
cctcggacca ggcggtggcg ttgggctgca ccacccgcac ggtcagccac agctggccgg 1080
cagactcagg ctggggcagc tcaggcagct cgatcagctg cttgccctgg ggggccacgt 1140
ccagtggcac ctcgccggag gccagaggct tgccgtccag ggccaccatc cagtgcagca 1200
gctcgttgtc gctgtgccgg aacaggtact cgctggtcac ctcgatggtc tggccggaca 1260
gccggaactg gaagaactgc tgctggtgct tggcttcggt cagggcaggg tggggggtcc 1320
ggtcggcgaa caccaggcca ttcatgcaga actgccggtc attgggggtg tcgccgaagt 1380
cgccgccgta ggcgctccaa gggttgccgt tctcgtcgta cttgatcagg ctctggtcca 1440
cccagtccca cacaaagccg ccctgcagcc gggggtactg ccggaaggcc tgccagtact 1500
tggcgaagcc gcccaggctg ttgcccatgg cgtgggcgta ctcgcacagg atcaggggcc 1560
gtgtctcgcc gggcagggac agccacttct tgatgctcca cttaggcacg gcggggaagg 1620
gctggtcctc gtccactctg gcgtacatgg ggcagatgat gtcggtggcg gtggtgtcgg 1680
ctcctccgcc ctcgtactgc acgggcctgc tggggtccac gctcttgatc caccggtaca 1740
gggcgtcgtg gttggcgccg tggccgctct cgttgcccag ggaccagatg atcacgctgg 1800
ggtggttccg gtcccgctgc accatccggg tcacgcgctc gctcatggcg ggcagccatc 1860
tggggtcgtc ggtcagcctg ttcatgggca ccatgccgtg tgtctcgatg ttggcctcgt 1920
ccaccacgta caggccgtat ctgtcgcaca gggtgtacca cagagggtgg ttggggtagt 1980
ggctgcaccg cacggcgttg aagttgttct gcttcatcag caggatgtcc tgcaccatgg 2040
tctgctcgtc catcacctgg ccgtgcaggg ggtggtgctc gtgccggttc acgccccgga 2100
tcagcagggg cttgccgttc agcagcagca ggccgttctc gatccgcacc tcccggaagc 2160
ccacgtcgca ggcctcggcc tcgatcaggg tgccgtcggc ggtgtgcagc tccaccacgg 2220
cccggtacag gttggggatc tcggcgctcc acagcttggg gttctccacg ttcagccgca 2280
gggtcactct gtcggcgtag ccgcccctct cgtcgatgat ctcgccgccg aaaggggcgg 2340
tgccgctggc cacctgtgtc tcgccctgcc acagggacac ggtcactctc aggtagtccc 2400
gcagctcgcc gcacatctgc acctcggcct ccagcacggc cctgctgaag tcgtcgttga 2460
accgggtggc cacgtggaag tcgctgatct gggtggtggg cttgtgcagc agggacacgt 2520
cccggaagat gccgctcatc cgccacatgt cctggtcctc caggtagctg ccgtcgctcc 2580
accgcagcac catcacggcc agcctgttct cgccggctct caggaaggcg ctcaggtcga 2640
actcgctggg cagccggcta tcctggccgt agcccaccca tctgccgttg caccacaggt 2700
ggaaggcgct gttcacgccg tcgaagatga tcctggtctg gccctcctgc agccaggact 2760
cgtccacgtt gaaggtcagg ctgtagcagc cggtggggtt ctcggtgggc acgaaggggg 2820
ggttcacggt gatggggtag gtcacgttgg tgtagatggg ggcgtcgtag ccgtgcatct 2880
gccagttgct gggcaccacc acggtgtcgg cctcgggcag gtcgcactcc agccagctct 2940
cgggcacggc ctcgggggca gggaaccagg cgaaccgcca ctcgccgttc aggctccgca 3000
gctgctggga gggcctgtcg gtccgggcct cctcgctgtt ccgccagctg gcaaagggag 3060
ggtgggcggc cagccggttc agctgggtca cgccagggtt ctcccagtcc cgccgctgca 3120
gcaccacggc caggctgtcg gtgatcatgg tggcggctct agactagatc ttccggaaca 3180
cactggcctc ccacagtggt agtactccac tgtctgggtg tacaaaaacc ggatccttta 3240
ccagacatga taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa 3300
aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc 3360
aataaacaag ttctcgaggc gcgcc                                       3385

<210> 8
<211> 1022
<212> PRT
<213> Artificial Sequence

<220> 
<223> LacZ recombination signal sequence

<400> 8
Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp Glu
 1               5                  10                  15      
Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe
            20                  25                  30          
Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln
        35                  40                  45              
Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala
    50                  55                  60                  
Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala
65                  70                  75                  80  
Asp Thr Val Val Val Pro Ser Asn Trp Gln Met His Gly Tyr Asp Ala
                85                  90                  95      
Pro Ile Tyr Thr Asn Val Thr Tyr Pro Ile Thr Val Asn Pro Pro Phe
            100                 105                 110         
Val Pro Thr Glu Asn Pro Thr Gly Cys Tyr Ser Leu Thr Phe Asn Val
        115                 120                 125             
Asp Glu Ser Trp Leu Gln Glu Gly Gln Thr Arg Ile Ile Phe Asp Gly
    130                 135                 140                 
Val Asn Ser Ala Phe His Leu Trp Cys Asn Gly Arg Trp Val Gly Tyr
145                 150                 155                 160 
Gly Gln Asp Ser Arg Leu Pro Ser Glu Phe Asp Leu Ser Ala Phe Leu
                165                 170                 175     
Arg Ala Gly Glu Asn Arg Leu Ala Val Met Val Leu Arg Trp Ser Asp
            180                 185                 190         
Gly Ser Tyr Leu Glu Asp Gln Asp Met Trp Arg Met Ser Gly Ile Phe
        195                 200                 205             
Arg Asp Val Ser Leu Leu His Lys Pro Thr Thr Gln Ile Ser Asp Phe
    210                 215                 220                 
His Val Ala Thr Arg Phe Asn Asp Asp Phe Ser Arg Ala Val Leu Glu
225                 230                 235                 240 
Ala Glu Val Gln Met Cys Gly Glu Leu Arg Asp Tyr Leu Arg Val Thr
                245                 250                 255     
Val Ser Leu Trp Gln Gly Glu Thr Gln Val Ala Ser Gly Thr Ala Pro
            260                 265                 270         
Phe Gly Gly Glu Ile Ile Asp Glu Arg Gly Gly Tyr Ala Asp Arg Val
        275                 280                 285             
Thr Leu Arg Leu Asn Val Glu Asn Pro Lys Leu Trp Ser Ala Glu Ile
    290                 295                 300                 
Pro Asn Leu Tyr Arg Ala Val Val Glu Leu His Thr Ala Asp Gly Thr
305                 310                 315                 320 
Leu Ile Glu Ala Glu Ala Cys Asp Val Gly Phe Arg Glu Val Arg Ile
                325                 330                 335     
Glu Asn Gly Leu Leu Leu Leu Asn Gly Lys Pro Leu Leu Ile Arg Gly
            340                 345                 350         
Val Asn Arg His Glu His His Pro Leu His Gly Gln Val Met Asp Glu
        355                 360                 365             
Gln Thr Met Val Gln Asp Ile Leu Leu Met Lys Gln Asn Asn Phe Asn
    370                 375                 380                 
Ala Val Arg Cys Ser His Tyr Pro Asn His Pro Leu Trp Tyr Thr Leu
385                 390                 395                 400 
Cys Asp Arg Tyr Gly Leu Tyr Val Val Asp Glu Ala Asn Ile Glu Thr
                405                 410                 415     
His Gly Met Val Pro Met Asn Arg Leu Thr Asp Asp Pro Arg Trp Leu
            420                 425                 430         
Pro Ala Met Ser Glu Arg Val Thr Arg Met Val Gln Arg Asp Arg Asn
        435                 440                 445             
His Pro Ser Val Ile Ile Trp Ser Leu Gly Asn Glu Ser Gly His Gly
    450                 455                 460                 
Ala Asn His Asp Ala Leu Tyr Arg Trp Ile Lys Ser Val Asp Pro Ser
465                 470                 475                 480 
Arg Pro Val Gln Tyr Glu Gly Gly Gly Ala Asp Thr Thr Ala Thr Asp
                485                 490                 495     
Ile Ile Cys Pro Met Tyr Ala Arg Val Asp Glu Asp Gln Pro Phe Pro
            500                 505                 510         
Ala Val Pro Lys Trp Ser Ile Lys Lys Trp Leu Ser Leu Pro Gly Glu
        515                 520                 525             
Thr Arg Pro Leu Ile Leu Cys Glu Tyr Ala His Ala Met Gly Asn Ser
    530                 535                 540                 
Leu Gly Gly Phe Ala Lys Tyr Trp Gln Ala Phe Arg Gln Tyr Pro Arg
545                 550                 555                 560 
Leu Gln Gly Gly Phe Val Trp Asp Trp Val Asp Gln Ser Leu Ile Lys
                565                 570                 575     
Tyr Asp Glu Asn Gly Asn Pro Trp Ser Ala Tyr Gly Gly Asp Phe Gly
            580                 585                 590         
Asp Thr Pro Asn Asp Arg Gln Phe Cys Met Asn Gly Leu Val Phe Ala
        595                 600                 605             
Asp Arg Thr Pro His Pro Ala Leu Thr Glu Ala Lys His Gln Gln Gln
    610                 615                 620                 
Phe Phe Gln Phe Arg Leu Ser Gly Gln Thr Ile Glu Val Thr Ser Glu
625                 630                 635                 640 
Tyr Leu Phe Arg His Ser Asp Asn Glu Leu Leu His Trp Met Val Ala
                645                 650                 655     
Leu Asp Gly Lys Pro Leu Ala Ser Gly Glu Val Pro Leu Asp Val Ala
            660                 665                 670         
Pro Gln Gly Lys Gln Leu Ile Glu Leu Pro Glu Leu Pro Gln Pro Glu
        675                 680                 685             
Ser Ala Gly Gln Leu Trp Leu Thr Val Arg Val Val Gln Pro Asn Ala
    690                 695                 700                 
Thr Ala Trp Ser Glu Ala Gly His Ile Ser Ala Trp Gln Gln Trp Arg
705                 710                 715                 720 
Leu Ala Glu Asn Leu Ser Val Thr Leu Pro Ala Ala Ser His Ala Ile
                725                 730                 735     
Pro His Leu Thr Thr Ser Glu Met Asp Phe Cys Ile Glu Leu Gly Asn
            740                 745                 750         
Lys Arg Trp Gln Phe Asn Arg Gln Ser Gly Phe Leu Ser Gln Met Trp
        755                 760                 765             
Ile Gly Asp Lys Lys Gln Leu Leu Thr Pro Leu Arg Asp Gln Phe Thr
    770                 775                 780                 
Arg Ala Pro Leu Asp Asn Asp Ile Gly Val Ser Glu Ala Thr Arg Ile
785                 790                 795                 800 
Asp Pro Asn Ala Trp Val Glu Arg Trp Lys Ala Ala Gly His Tyr Gln
                805                 810                 815     
Ala Glu Ala Ala Leu Leu Gln Cys Thr Ala Asp Thr Leu Ala Asp Ala
            820                 825                 830         
Val Leu Ile Thr Thr Ala His Ala Trp Gln His Gln Gly Lys Thr Leu
        835                 840                 845             
Phe Ile Ser Arg Lys Thr Tyr Arg Ile Asp Gly Ser Gly Gln Met Ala
    850                 855                 860                 
Ile Thr Val Asp Val Glu Val Ala Ser Asp Thr Pro His Pro Ala Arg
865                 870                 875                 880 
Ile Gly Leu Asn Cys Gln Leu Ala Gln Val Ala Glu Arg Val Asn Trp
                885                 890                 895     
Leu Gly Leu Gly Pro Gln Glu Asn Tyr Pro Asp Arg Leu Thr Ala Ala
            900                 905                 910         
Cys Phe Asp Arg Trp Asp Leu Pro Leu Ser Asp Met Tyr Thr Pro Tyr
        915                 920                 925             
Val Phe Pro Ser Glu Asn Gly Leu Arg Cys Gly Thr Arg Glu Leu Asn
    930                 935                 940                 
Tyr Gly Pro His Gln Trp Arg Gly Asp Phe Gln Phe Asn Ile Ser Arg
945                 950                 955                 960 
Tyr Ser Gln Gln Gln Leu Met Glu Thr Ser His Arg His Leu Leu His
                965                 970                 975     
Ala Glu Glu Gly Thr Trp Leu Asn Ile Asp Gly Phe His Met Gly Ile
            980                 985                 990         
Gly Gly Asp Asp Ser Trp Ser Pro Ser Val Ser Ala Glu Phe Gln Leu
        995                 1000                1005            
Ser Ala Gly Arg Tyr His Tyr Gln Leu Val Trp Cys Gln Lys
    1010                1015                1020        


<210> 9
<211> 889
<212> DNA
<213> Artificial Sequence

<220> 
<223> Gene optimized sequence for expression in
      mammalian cells

<400> 9
ggcgcgccaa gcttgccgcc accatggaca tgcgggtgcc cgcccagctc ctggggctcc 60
tgctactctg gctccgaggt aaggatggag aacactagga atttactcct cgagctcgcg 120
gccgcagcca gtgtgctcag tactgactgg aacttcaggg aagttctctg ataacatgat 180
taatagtaag aatatttgtt tttatgtttc caatctcagg tgccagatgt gacatccaga 240
tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc atcacctgcc 300
gggccagcca gagcatcagc aactacctga actggtatca gcagaagccc ggcaaggccc 360
ccaagttcct gatctacggc gccagctccc tggaaagcgg cgtgcccagc cggtttagcg 420
gcagcggctc cggcaccgac ttcaccctga ccatcagcag cctgcagccc gaggacttcg 480
ccacctacta ctgccagcag agctacagca accccctgac ctttggcggc ggaacaaagg 540
tggagatcaa gcggaccgtg gccgctccca gcgtgttcat cttccccccc agcgacgagc 600
agcttaagag cggtaccgct agcgtggtgt gcctgctgaa caacttctac ccccgggagg 660
ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag gaaagcgtca 720
ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc ctgagcaagg 780
ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc ctgtccagcc 840
ccgtgaccaa gagcttcaac cggggcgagt gctaatctag attaattaa             889

<210> 10
<211> 236
<212> PRT
<213> Artificial Sequence

<220> 
<223> Gene optimized sequence for expression in
      mammalian cells

<400> 10
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
 1               5                  10                  15      
Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
        35                  40                  45              
Gln Ser Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Phe Leu Ile Tyr Gly Ala Ser Ser Leu Glu Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
            100                 105                 110         
Ser Tyr Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
        115                 120                 125             
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
    130                 135                 140                 
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
145                 150                 155                 160 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
                165                 170                 175     
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
            180                 185                 190         
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
        195                 200                 205             
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
    210                 215                 220                 
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235     


<210> 11
<211> 3134
<212> DNA
<213> Artificial Sequence

<220> 
<223> A heavy chain vector designed to express human IgG
      on the cell surface

<400> 11
ggcgcgccgg atccactagc cagtgtggtg cttaagtgca gatatcctgt ggaatgtgtg 60
tcagttaggg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca 120
tctcaattag tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat 180
gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc 240
gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat 300
ttatgcagag gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt 360
ttttggaggc ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc 420
tgatcaagag acaggatgag gagcggccgc gccgccacca tggggtcaac cgccatcctc 480
gccctcctcc tggctgttct ccaaggagtc tgtgccgagg tgcagctggt gcagtctgga 540
gcagaggtga aaaagcccgg ggagtctctg aaaatctcct gtaagggttc tggatacagc 600
tttaccagct actggatcgg ctgggtgcgc cagatgcccg ggaaaggcct ggagtggatg 660
gggatcatct atcctggtga ctctgatacc agatacagcc cgtccttcca aggccaggtc 720
accatctcag ccgacaagtc catcagcacc gcctacctcc agtggagcag cctgaaggcc 780
tcggacaccg ccatgtatta ctgtgcgaga caggacggcg acagctttga ctactggggc 840
cagggaaccc tggtcaccgt ctcctcaggt gagtcctcac aacctctctc ctgctttaac 900
tctgaagggt tttgctgcat ttctgggggg aaataagggt gctgggtctc ctgccaagag 960
agcccctgca gagggccacc ctaggcctct ggggtccaat gcccaacaac ccccgggccc 1020
tccccgggct cagtctgaga gggtcccagg gacgtagcgg ggcgccggtt tttgtacacc 1080
cagacagtgg agtactacca ctgtgacaac tggttcgacc cctggggcca gggaaccctg 1140
gtcaccgtct cctcaggtga gtcctcacca ccccctctct gagtccactt agggagactc 1200
agcttgccag ggtctcaggg tcagagtctt ggaggcattt tggaggtcag gaaggaggcc 1260
agcagagggt tccatgagaa gggcaggaca gggccacgga cagtcagctt ccatgtgacg 1320
cccggagaca gaaggtctct gggtggctgg tttttgtaca cccagacagt ggagtactac 1380
cactgtgatt actactacta ctactacatg gacgtctggg gcaaagggac cacggtcacc 1440
gtctcctcag gtaagaatgg ccactctagg gcctttgttt tctgctactg cctgtggggt 1500
ttcctgagca ttgcaggttg gtcctcgggg catgttccga ggggacctgg gcggacgcta 1560
gcgaacctcg cggacagtta agaacccagg ggcctctgcg ccctgggccc agctctgtcc 1620
cacaccgcgg tcacatggca ccacctctct tgcagcctcc accaagggcc catcggtctt 1680
ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt 1740
caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg 1800
cgtgcatacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt 1860
gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc 1920
cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg 1980
cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa 2040
acccaaggac accctcatga tctctagaac ccctgaggtc acatgcgtgg tggtggacgt 2100
gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa 2160
tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct 2220
caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa 2280
agccctccca gcccccatcg agaaaaccat ctccaaagcc aaaggtggga cccgtggggt 2340
gcgaataact tcgtataatg tatgctatac gaagttatgg gccacatgga attcagaggc 2400
cggctcggcc caccctctgc cctgagagtg accgctgtac caacctctgt ccctacaggg 2460
cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac 2520
caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 2580
gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 2640
ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2700
gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2760
tccctgtctc cgggcaaagc tgtgggccag gacacgcagg aggtcatcgt ggtgccacac 2820
tccttgccct ttaaggtggt ggtgatctca gccatcctgg ccctggtggt gctcaccatc 2880
atctccctta tcatcctcat catgctttgg cagaagaagc cacgttaggt tttccgggac 2940
gccggctgga tgatcctcca gcgcggggat ctcatgctgg agttcttcgc ccaccccaac 3000
ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat 3060
aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat 3120
catgtctgac gcgt                                                   3134

<210> 12
<211> 515
<212> PRT
<213> Artificial Sequence

<220> 
<223> A heavy chain vector designed to express human IgG
      on the cell surface

<400> 12
Met Gly Ser Thr Ala Ile Leu Ala Leu Leu Leu Ala Val Leu Gln Gly
 1               5                  10                  15      
Val Cys Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe
        35                  40                  45              
Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser
65                  70                  75                  80  
Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser
                85                  90                  95      
Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gln Asp Gly Asp Ser Phe Asp Tyr Trp Gly Gln
        115                 120                 125             
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
    130                 135                 140                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
145                 150                 155                 160 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
                165                 170                 175     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
            180                 185                 190         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
        195                 200                 205             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
    210                 215                 220                 
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
225                 230                 235                 240 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
                245                 250                 255     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
            260                 265                 270         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
        275                 280                 285             
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
    290                 295                 300                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
305                 310                 315                 320 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
                325                 330                 335     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
            340                 345                 350         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
        355                 360                 365             
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
    370                 375                 380                 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
385                 390                 395                 400 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
                405                 410                 415     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
            420                 425                 430         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
        435                 440                 445             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
    450                 455                 460                 
Gly Lys Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His
465                 470                 475                 480 
Ser Leu Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val
                485                 490                 495     
Val Leu Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys
            500                 505                 510         
Lys Pro Arg
        515 


<210> 13
<211> 11
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 13
ctaactgggg a                                                      11


<210> 14
<211> 4193
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleotide sequence variant of the V64 antibody
      generation vector

<400> 14
ggatccacta gccagtgtgg tgcttaagtg cagatatcgc ggccgcctgt ggaatgtgtg 60
tcagttaggg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca 120
tctcaattag tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat 180
gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc 240
gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat 300
ttatgcagag gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt 360
ttttggaggc ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc 420
tgatcaagag acaggatgag gagccgccac catggggtca accgccatcc tcgccctcct 480
cctggctgtt ctccaaggag tctgtgccga ggtgcagctg gtgcagtctg gagcagaggt 540
gaaaaagccc ggggagtctc tgaaaatctc ctgtaagggt tctggataca gctttaccag 600
ctactggatc ggctgggtgc gccagatgcc cgggaaaggc ctggagtgga tggggatcat 660
ctatcctggt gactctgata ccagatacag cccgtccttc caaggccagg tcaccatctc 720
agccgacaag tccatcagca ccgcctacct ccagtggagc agcctgaagg cctcggacac 780
cgccatgtat tactgtgcga gacacacagt ggtagtactc cactgtctgg gtgtacaaaa 840
acctccacac cgcaggtgca gaaactagtc tgtggaatgt gtgtcagtta gggtgtggaa 900
agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa 960
ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca 1020
attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca 1080
gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg 1140
ccgcctctgc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct 1200
tttgcaaaaa gctcccggga gcttgtatat ccattttcgg atctgatcaa gagacaggat 1260
gaggagccgc caccatggag tttgggctga gctgggtttt ccttgttgct attataaaag 1320
gtgtccagtg tcaggtacag ctccagcagt caggtccagg actggtgaag ccctcgcaga 1380
ccctctcact cacctgtgcc atctccgggg acagtgtctc tagcaacagt gctgcttgga 1440
actggatcag gcagtcccca tcgagaggcc ttgagtggct gggaaggaca tactacaggt 1500
ccaagtggta taatgattat gcagtatctg tgaaaagtcg aataaccatc aacccagaca 1560
catccaagaa ccagttctcc ctccagctga actctgtgac tcccgaggac acggctgtgt 1620
attactgtgc aagagacaca gtggtagtac tccactgtct gggtgtacaa aaacctccct 1680
gcacggatgc tcaggtccgg accagtgggc accctcttcc aggacagtcc tcagtgatat 1740
cacatcggga acccacatct ggatcaggac ggcacccaga acacaagatg gcccatgggg 1800
acagccccac agcccagccc ttcccagacc cctaaaaggt gtcccacccc ctgcacctac 1860
cccaggacta aaaatccagg aggcctgact cctgcacatg ctctgaccgg atgtcacctc 1920
ggcccctcct ggaggggaca ggagccctgg agggtgagtc agaccctcct gccctcgacg 1980
gcaggcgggg aagattcaga ccggtctgag atccccagga tgcagcacca ctgtcaatgg 2040
gggccccaga cgcctggacc agcacctgcg tgggaaatgc ctctgggctc actgaggggc 2100
tttttgtgaa ggccctcctg ctatgtgact atggtgctaa ctaccacagt gatgaaccca 2160
gcagcaaaaa ctgaccggac tcccagggtt tatgcacact tctcggctca gagttctcca 2220
ggataagaag agccaggccc aaggatttct gcccagaccc tcggcctcta gggacacctt 2280
ggccatgaaa gcccatgggc tggtgcccca cacttcatct gccttcaaac aagggcttca 2340
gagggctctg aggtgacctc actcatgacc acaggtgcct gccagctgca ccgaaccctg 2400
tcccaacagc tgccacagtt ccaacagcca attcctaggg ccgggaattg ctgtagacac 2460
cagccttgtt ccagcacctc ctgccaattg cctggattcc catcctggct ggaatcaaga 2520
gggcagcatc cgcaagctta tgctcccccg ggaccccggg ctgtggtttt tgtacaccca 2580
gacagtggag tactaccact gtggctgaat acttccagca ctggggccag ggcaccctgg 2640
tcaccgtctc ctcaggtgag tctgctgtct ggggatagcg gggagccagg tgtactgggc 2700
caggcaaggg ctttgggctc cttctccggc tgtttgggac cacgttcagc agaaggcctt 2760
tctttgggaa ctgggactct gctgctgggg ggcttcagac ttggggacag gtgctcagca 2820
aaggaggtcg gcaggagggc ggagggtggt ttttgtacac ccagacagtg gagtactacc 2880
actgtgctac tggtacttcg atctctgggg ccgtggcacc ctggtcactg tctcctcagg 2940
tgagtcccac tgcacccccc tcccagtctt ctctgtccag gcaccaggcc aggtatctgg 3000
ggtgtgcagc cggcctgggt ctggcctgag gccacaagcc cgggggtctg tgtggctggg 3060
gacagggacg ccggctgcct ctgctctgtg cttgggccat gtgacccatt cgagtgtcct 3120
gcacgggcac aggtttttgt acacccagac agtggagtac taccactgtg tgatgctttt 3180
gatatctggg gccaagggac aatggtcacc gtctcttcag gtaagatggc tttccttctg 3240
cctcctttct ctgggcccag cgtcctctgt cctggagctg ggagataatg tccgggggct 3300
ccttggtctg cgctgggcaa agggtgggca gagtcatgct tgtgctgggg acaaaatgac 3360
cttgggacac ggggctggct gccacggccg gcccgggaca gtcggagagt caggtttttg 3420
tacacccaga cagtggagta ctaccactgt gactactttg actactgggg ccagggaacc 3480
ctggtcaccg tctcctcagg tgagtcctca caacctctct cctgctttaa ctctgaaggg 3540
ttttgctgca tttctggggg gaaataaggg tgctgggtct cctgccaaga gagcccctgc 3600
agagggccac cctaggcctc tggggtccaa tgcccaacaa cccccgggcc ctccccgggc 3660
tcagtctgag agggtcccag ggacgtagcg gggcgccggt ttttgtacac ccagacagtg 3720
gagtactacc actgtgacaa ctggttcgac ccctggggcc agggaaccct ggtcaccgtc 3780
tcctcaggtg agtcctcacc accccctctc tgagtccact tagggagact cagcttgcca 3840
gggtctcagg gtcagagtct tggaggcatt ttggaggtca ggaaggaggc cagcagaggg 3900
ttccatgaga agggcaggac agggccacgg acagtcagct tccatgtgac gcccggagac 3960
agaaggtctc tgggtggctg gtttttgtac acccagacag tggagtacta ccactgtgat 4020
tactactact actactacat ggacgtctgg ggcaaaggga ccacggtcac cgtctcctca 4080
ggtaagaatg gccactctag ggcctttgtt ttctgctact gcctgtgggg tttcctgagc 4140
attgcaggtt ggtcctcggg gcatgttccg aggggacctg ggcggacgct agc        4193

<210> 15
<211> 4205
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleotide sequence variant of the V64 antibody
      generation vector

<400> 15
ggatccacta gccagtgtgg tgcttaagtg cagatatcgc ggccgcctgt ggaatgtgtg 60
tcagttaggg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca 120
tctcaattag tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat 180
gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc 240
gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat 300
ttatgcagag gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt 360
ttttggaggc ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc 420
tgatcaagag acaggatgag gagccgccac catggggtca accgccatcc tcgccctcct 480
cctggctgtt ctccaaggag tctgtgccga ggtgcagctg gtgcagtctg gagcagaggt 540
gaaaaagccc ggggagtctc tgaaaatctc ctgtaagggt tctggataca gctttaccag 600
ctactggatc ggctgggtgc gccagatgcc cgggaaaggc ctggagtgga tggggatcat 660
ctatcctggt gactctgata ccagatacag cccgtccttc caaggccagg tcaccatctc 720
agccgacaag tccatcagca ccgcctacct ccagtggagc agcctgaagg cctcggacac 780
cgccatgtat tactgtgcga gacacacagt ggtagtactc cactgtctgg gtgtacaaaa 840
acctccacac cgcaggtgca gaaactagtc tgtggaatgt gtgtcagtta gggtgtggaa 900
agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa 960
ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca 1020
attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca 1080
gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg 1140
ccgcctctgc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct 1200
tttgcaaaaa gctcccggga gcttgtatat ccattttcgg atctgatcaa gagacaggat 1260
gaggagccgc caccatggag tttgggctga gctgggtttt ccttgttgct attataaaag 1320
gtgtccagtg tcaggtacag ctccagcagt caggtccagg actggtgaag ccctcgcaga 1380
ccctctcact cacctgtgcc atctccgggg acagtgtctc tagcaacagt gctgcttgga 1440
actggatcag gcagtcccca tcgagaggcc ttgagtggct gggaaggaca tactacaggt 1500
ccaagtggta taatgattat gcagtatctg tgaaaagtcg aataaccatc aacccagaca 1560
catccaagaa ccagttctcc ctccagctga actctgtgac tcccgaggac acggctgtgt 1620
attactgtgc aagagacaca gtggtagtac tccactgtct gggtgtacaa aaacctccct 1680
gcacggatgc tcaggtccgg accagtgggc accttcttcc aggacattcc tcggtcgcat 1740
cacagcaggc acccacatct ggatcaggac ggcccccaga acacaagatg gcccatgggg 1800
acagccccac aacccaggcc ttcccagacc cctaaaaggc gtcccacccc ctgcacctgc 1860
cccagggcta aaaatccagg aggcttgact cccgcatacc ctccagccag acatcacctc 1920
agccccctcc tggaggggac aggagcccgg gagggtgagt cagacccacc tgccctcgat 1980
ggcaggcggg gaagattcag aaaggcctga gatccccagg acgcagcacc actgtcaatg 2040
ggggccccag acgcctggac cagggcctgc gtgggaaagg ccgctgggca cactcagggg 2100
ctttttgtga aggcccctcc tactgtgtga ctacggtgac taccacagtg atgaaactag 2160
cagcaaaaac tggccggaca cccagggacc atgcacactt ctcagcttgg agctctccag 2220
gaccagaaga gtcaggtctg agggtttgta gccagaccct cggcctctag ggacaccctg 2280
gccatcacag cagatgggct ggtgccccac atgccatctg ctccaaacag gggcttcaga 2340
gggctctgag gtgacttcac tcatgaccac aggtgccctg gccccttccc cgccagctac 2400
accgaaccct gtcccaacag ctgccccagt tccaacagcc aattcctggg gcccagaatt 2460
gctgtagaca ccagcctcgt tccagcacct cctgccaatt gcctggattc acatcctggc 2520
tggaatcaag agggcagcat ccgcaagctt atgctccccc gggaccccgg gctgtggttt 2580
ttgtacaccc agacagtgga gtactaccac tgtggctgaa tacttccagc actggggcca 2640
gggcaccctg gtcaccgtct cctcaggtga gtctgctgtc tggggatagc ggggagccag 2700
gtgtactggg ccaggcaagg gctttgggct ccttctccgg ctgtttggga ccacgttcag 2760
cagaaggcct ttctttggga actgggactc tgctgctggg gggcttcaga cttggggaca 2820
ggtgctcagc aaaggaggtc ggcaggaggg cggagggtgg tttttgtaca cccagacagt 2880
ggagtactac cactgtgcta ctggtacttc gatctctggg gccgtggcac cctggtcact 2940
gtctcctcag gtgagtccca ctgcaccccc ctcccagtct tctctgtcca ggcaccaggc 3000
caggtatctg gggtgtgcag ccggcctggg tctggcctga ggccacaagc ccgggggtct 3060
gtgtggctgg ggacagggac gccggctgcc tctgctctgt gcttgggcca tgtgacccat 3120
tcgagtgtcc tgcacgggca caggtttttg tacacccaga cagtggagta ctaccactgt 3180
gtgatgcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca ggtaagatgg 3240
ctttccttct gcctcctttc tctgggccca gcgtcctctg tcctggagct gggagataat 3300
gtccgggggc tccttggtct gcgctgggca aagggtgggc agagtcatgc ttgtgctggg 3360
gacaaaatga ccttgggaca cggggctggc tgccacggcc ggcccgggac agtcggagag 3420
tcaggttttt gtacacccag acagtggagt actaccactg tgactacttt gactactggg 3480
gccagggaac cctggtcacc gtctcctcag gtgagtcctc acaacctctc tcctgcttta 3540
actctgaagg gttttgctgc atttctgggg ggaaataagg gtgctgggtc tcctgccaag 3600
agagcccctg cagagggcca ccctaggcct ctggggtcca atgcccaaca acccccgggc 3660
cctccccggg ctcagtctga gagggtccca gggacgtagc ggggcgccgg tttttgtaca 3720
cccagacagt ggagtactac cactgtgaca actggttcga cccctggggc cagggaaccc 3780
tggtcaccgt ctcctcaggt gagtcctcac caccccctct ctgagtccac ttagggagac 3840
tcagcttgcc agggtctcag ggtcagagtc ttggaggcat tttggaggtc aggaaggagg 3900
ccagcagagg gttccatgag aagggcagga cagggccacg gacagtcagc ttccatgtga 3960
cgcccggaga cagaaggtct ctgggtggct ggtttttgta cacccagaca gtggagtact 4020
accactgtga ttactactac tactactaca tggacgtctg gggcaaaggg accacggtca 4080
ccgtctcctc aggtaagaat ggccactcta gggcctttgt tttctgctac tgcctgtggg 4140
gtttcctgag cattgcaggt tggtcctcgg ggcatgttcc gaggggacct gggcggacgc 4200
tagcc                                                             4205

<210> 16
<211> 3365
<212> DNA
<213> Artificial Sequence

<220> 
<223> V67 vector sequence

<400> 16
ggatccacta gccagtgtgg tgcttaagtg cagatatcgc ggccgcctgt ggaatgtgtg 60
tcagttaggg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca 120
tctcaattag tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat 180
gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc 240
gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat 300
ttatgcagag gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt 360
ttttggaggc ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc 420
tgatcaagag acaggatgag gagccgccac catggggtca accgccatcc tcgccctcct 480
cctggctgtt ctccaaggag tctgtgccga ggtgcagctg gtgcagtctg gagcagaggt 540
gaaaaagccc ggggagtctc tgaaaatctc ctgtaagggt tctggataca gctttaccag 600
ctactggatc ggctgggtgc gccagatgcc cgggaaaggc ctggagtgga tggggatcat 660
ctatcctggt gactctgata ccagatacag cccgtccttc caaggccagg tcaccatctc 720
agccgacaag tccatcagca ccgcctacct ccagtggagc agcctgaagg cctcggacac 780
cgccatgtat tactgtgcga gacacacagt ggtagtactc cactgtctgg gtgtacaaaa 840
acctccacac cgcaggtgca gaaactagcc ggaccagtgg gcaccctctt ccaggacagt 900
cctcagtgat atcacatcgg gaacccacat ctggatcagg acggcaccca gaacacaaga 960
tggcccatgg ggacagcccc acagcccagc ccttcccaga cccctaaaag gtgtcccacc 1020
ccctgcacct accccaggac taaaaatcca ggaggcctga ctcctgcaca tgctctgacc 1080
ggatgtcacc tcggcccctc ctggagggga caggagccct ggagggtgag tcagaccctc 1140
ctgccctcga cggcaggcgg ggaagattca gaccggtctg agatccccag gatgcagcac 1200
cactgtcaat gggggcccca gacgcctgga ccagcacctg cgtgggaaat gcctctgggc 1260
tcactgaggg gctttttgtg aaggccctcc tgctatgtga ctatggtgct aactaccaca 1320
gtgatgaacc cagcagcaaa aactgaccgg actcccaggg tttatgcaca cttctcggct 1380
cagagttctc caggataaga agagccaggc ccaaggattt ctgcccagac cctcggcctc 1440
tagggacacc ttggccatga aagcccatgg gctggtgccc cacacttcat ctgccttcaa 1500
acaagggctt cagagggctc tgaggtgacc tcactcatga ccacaggtgc ctgccagctg 1560
caccgaaccc tgtcccaaca gctgccacag ttccaacagc caattcctag ggccgggaat 1620
tgctgtagac accagccttg ttccagcacc tcctgccaat tgcctggatt cccatcctgg 1680
ctggaatcaa gagggcagca tccgcaagct tatgctcccc cgggaccccg ggctgtggtt 1740
tttgtacacc cagacagtgg agtactacca ctgtggctga atacttccag cactggggcc 1800
agggcaccct ggtcaccgtc tcctcaggtg agtctgctgt ctggggatag cggggagcca 1860
ggtgtactgg gccaggcaag ggctttgggc tccttctccg gctgtttggg accacgttca 1920
gcagaaggcc tttctttggg aactgggact ctgctgctgg ggggcttcag acttggggac 1980
aggtgctcag caaaggaggt cggcaggagg gcggagggtg gtttttgtac acccagacag 2040
tggagtacta ccactgtgct actggtactt cgatctctgg ggccgtggca ccctggtcac 2100
tgtctcctca ggtgagtccc actgcacccc cctcccagtc ttctctgtcc aggcaccagg 2160
ccaggtatct ggggtgtgca gccggcctgg gtctggcctg aggccacaag cccgggggtc 2220
tgtgtggctg gggacaggga cgccggctgc ctctgctctg tgcttgggcc atgtgaccca 2280
ttcgagtgtc ctgcacgggc acaggttttt gtacacccag acagtggagt actaccactg 2340
tgtgatgctt ttgatatctg gggccaaggg acaatggtca ccgtctcttc aggtaagatg 2400
gctttccttc tgcctccttt ctctgggccc agcgtcctct gtcctggagc tgggagataa 2460
tgtccggggg ctccttggtc tgcgctgggc aaagggtggg cagagtcatg cttgtgctgg 2520
ggacaaaatg accttgggac acggggctgg ctgccacggc cggcccggga cagtcggaga 2580
gtcaggtttt tgtacaccca gacagtggag tactaccact gtgactactt tgactactgg 2640
ggccagggaa ccctggtcac cgtctcctca ggtgagtcct cacaacctct ctcctgcttt 2700
aactctgaag ggttttgctg catttctggg gggaaataag ggtgctgggt ctcctgccaa 2760
gagagcccct gcagagggcc accctaggcc tctggggtcc aatgcccaac aacccccggg 2820
ccctccccgg gctcagtctg agagggtccc agggacgtag cggggcgccg gtttttgtac 2880
acccagacag tggagtacta ccactgtgac aactggttcg acccctgggg ccagggaacc 2940
ctggtcaccg tctcctcagg tgagtcctca ccaccccctc tctgagtcca cttagggaga 3000
ctcagcttgc cagggtctca gggtcagagt cttggaggca ttttggaggt caggaaggag 3060
gccagcagag ggttccatga gaagggcagg acagggccac ggacagtcag cttccatgtg 3120
acgcccggag acagaaggtc tctgggtggc tggtttttgt acacccagac agtggagtac 3180
taccactgtg attactacta ctactactac atggacgtct ggggcaaagg gaccacggtc 3240
accgtctcct caggtaagaa tggccactct agggcctttg ttttctgcta ctgcctgtgg 3300
ggtttcctga gcattgcagg ttggtcctcg gggcatgttc cgaggggacc tgggcggacg 3360
ctagc                                                             3365

<210> 17
<211> 2158
<212> DNA
<213> Artificial Sequence

<220> 
<223> V86 antibody generating substrate sequence

<400> 17
ggatccacta gccagtgtgg tgcttaagtg cagatatcgc ggccgcctgt ggaatgtgtg 60
tcagttaggg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca 120
tctcaattag tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat 180
gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc 240
gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat 300
ttatgcagag gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt 360
ttttggaggc ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc 420
tgatcaagag acaggatgag gagccgccac catggggtca accgccatcc tcgccctcct 480
cctggctgtt ctccaaggag tctgtgccga ggtgcagctg gtgcagtctg gagcagaggt 540
gaaaaagccc ggggagtctc tgaaaatctc ctgtaagggt tctggataca gctttaccag 600
ctactggatc ggctgggtgc gccagatgcc cgggaaaggc ctggagtgga tggggatcat 660
ctatcctggt gactctgata ccagatacag cccgtccttc caaggccagg tcaccatctc 720
agccgacaag tccatcagca ccgcctacct ccagtggagc agcctgaagg cctcggacac 780
cgccatgtat tactgtgcga gacacacagt ggtagtactc cactgtctgg gtgtacaaaa 840
acctccacac cgcaggtgca gaaactagcc ggaccagtgg gcaccctctt ccaggacagt 900
cctcagtgat atcacatcgg gaacccacat ctggatcagg acggcaccca gaacacaaga 960
tggcccatgg ggacagcccc acagcccagc ccttcccaga cccctaaaag gtgtcccacc 1020
ccctgcacct accccaggac taaaaatcca ggaggcctga ctcctgcaca tgctctgacc 1080
ggatgtcacc tcggcccctc ctggagggga caggagccct ggagggtgag tcagaccctc 1140
ctgccctcga cggcaggcgg ggaagattca gaccggtctg agatccccag gatgcagcac 1200
cactgtcaat gggggcccca gacgcctgga ccagcacctg cgtgggaaat gcctctgggc 1260
tcactgaggg gctttttgtg aaggccctcc tgctatgtga ctatggtgct aactaccaca 1320
gtgatgaacc cagcagcaaa aactgaccgg actcccaggg tttatgcaca cttctcggct 1380
cagagttctc caggataaga agagccaggc ccaaggattt ctgcccagac cctcggcctc 1440
tagggacacc ttggccatga aagcccatgg gctggtgccc cacacttcat ctgccttcaa 1500
acaagggctt cagagggctc tgaggtgacc tcactcatga ccacaggtgc ctgccagctg 1560
caccgaaccc tgtcccaaca gctgccacag ttccaacagc caattcctag ggccgggaat 1620
tgctgtagac accagccttg ttccagcacc tcctgccaat tgcctggatt cccatcctgg 1680
ctggaatcaa gagggcagca tccgcaagct tctgcctcct ttctctgggc ccagcgtcct 1740
ctgtcctgga gctgggagat aatgtccggg ggctccttgg tctgcgctgg gcaaagggtg 1800
ggcagagtca tgcttgtgct ggggacaaaa tgaccttggg acacggggct ggctgccacg 1860
gccggcccgg gacagtcgga gagtcaggtt tttgtacacc cagacagtgg agtactacca 1920
ctgtgactac tttgactact ggggccaggg aaccctggtc accgtctcct caggtgagtc 1980
ctcacaacct ctctcctgct ttaactctga agggttttgc tgcatttctg gggggaaata 2040
agggtgctgg gtctcctgcc aagagagccc ctgcagaggg ccaccctagg cctctggggt 2100
ccaatgccca acaacccccg ggccctcccc gggctcagtc tgagagggtc ccgctagc   2158

<210> 18
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 18
cacagtgctc cagggctgaa caaaaacc                                    28

<210> 19
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 19
cacagtggta gtactccact gtctgggtgt acaaaaacc                        39

<210> 20
<211> 28
<212> DNA
<213> `Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 20
cacagtggta cagaccaata caaaaacc                                    28

<210> 21
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 21
cacatagcag gagggccttc acaaaaagc                                   29

<210> 22
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 22
cacagtgatg aacccagcag caaaaact                                    28

<210> 23
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 23
cacagtagga ggggccttca caaaaagc                                    28

<210> 24
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 24
cacagtgatg aaactagcag caaaaact                                    28

<210> 25
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 25
cacatagcag gagggccttc acaaaaagc                                   29

<210> 26
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 26
cacagtgatg aacccagcag caaaaact                                    28

<210> 27
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 27
cacatagcag gagggccttc acaaaaagc                                   29

<210> 28
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 28
cacagtgatg aacccagcag caaaaact                                    28

<210> 29
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 29
cacagtgata cagaccttaa caaaaacc                                    28

<210> 30
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 30
cacagtggta gtactccact gtctggctgt acaaaaacc                        39

<210> 31
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 31
cacagtgcta cagactggaa caaaaacc                                    28

<210> 32
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 32
cacagtggta gtactccact gtctggctgt acaaaaacc                        39

<210> 33
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 33
cacagtgctc cagggctgaa caaaaacc                                    28

<210> 34
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 34
cacagtggta gtactccact gtctgggtgt acaaaaacc                        39

<210> 35
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 35
cacagtgcta cagactggaa caaaaacc                                    28

<210> 36
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 36
cacagtgttg caaccacatc ctgagtgtgt acaaaaacc                        39

<210> 37
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 37
cacagtgcta cagactggaa caaaaacc                                    28

<210> 38
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 38
cacagtggta gtactccact gtctggctgt acaaaaacc                        39

<210> 39
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 39
cacagtgcta cagactggaa caaaaacc                                    28

<210> 40
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 40
cacagtgacg gagataaagg aggaagcagg acaaaaacc                        39

<210> 41
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 41
cacagtggta cagaccaata cagaaacc                                    28

<210> 42
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 42
cacagtggcc gggccccgcg gcccggcggc acaaaaacc                        39

<210> 43
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 43
cacggtgcta cagactggaa caaaaacc                                    28

<210> 44
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 44
cacagtggta gtactccact gtctggctgt acaaaaacc                        39

<210> 45
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 45
cacaatgcta cagactggaa caaaaacc                                    28

<210> 46
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 46
cacagtggta gtactccact gtctggctgt acaaaaacc                        39

<210> 47
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 47
cacagcgcta cagactggaa caaaaacc                                    28

<210> 48
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 48
cacagtggta gtactccact gtctggctgt acaaaaacc                        39

<210> 49
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 49
cacagtgcta cagactggaa caaaaacc                                    28

<210> 50
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 50
cacaatggta gtactccact gtctggctgt acaaaaacc                        39

<210> 51
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 51
cacagtgcta cagactggaa caaaaacc                                    28

<210> 52
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 52
cacagcggta gtactccact gtctggctgt acaaaaacc                        39

<210> 53
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 53
cacagtgcta cagactggaa caaaaacc                                    28

<210> 54
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 54
cacagtagta gtactccact gtctggctgt acaaaaacc                        39

<210> 55
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 55
cacagtgcta cagactggaa caaaaacc                                    28

<210> 56
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 56
cacagtggta gtactccact gtctggctgt acaataacc                        39

<210> 57
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 57
cacagtgcta cagactggaa caaaaacc                                    28

<210> 58
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 58
cacagtggta gtactccact gtctggctgt acaagaacc                        39

<210> 59
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 59
cacagtgcta cagactggaa caaaaacc                                    28

<210> 60
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 60
cacagtggta gtactccact gtctggctgt acacgaacc                        39

<210> 61
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 61
cacagtgcta cagactggac aaaaaccc                                    28

<210> 62
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 62
cacagtggta gtactccact gtctggctgt acaaaaacc                        39

<210> 63
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 63
cacagtgcta cagactggaa caaaaacc                                    28

<210> 64
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 64
cacagtggta gtactccact gtctggctgt acacgaacc                        39

<210> 65
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 65
cacaatgcta cagactggaa caaaaacc                                    28

<210> 66
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 66
cacaatggta gtactccact gtctggctgt acaaaaacc                        39

<210> 67
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 67
cacagcgcta cagactggaa caaaaacc                                    28

<210> 68
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 68
cacagcggta gtactccact gtctggctgt acaaaaacc                        39

<210> 69
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 69
tacagtgcta cagactggaa caaaaacc                                    28

<210> 70
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 70
cacagtagta gtactccact gtctggctgt acaaaaacc                        39

<210> 71
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 71
gacagtgcta cagactggaa caaaaacc                                    28

<210> 72
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 72
cacagtggta gtactccact gtctggctgt acaaaaacc                        39

<210> 73
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 73
catagtgcta cagactggaa caaaaacc                                    28

<210> 74
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 74
cacaatggta gtactccact gtctggctgt acaaaaacc                        39

<210> 75
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 75
cacaatgcta cagactggaa caaaaacc                                    28

<210> 76
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 76
catagtggta gtactccact gtctggctgt acaaaaacc                        39

<210> 77
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 77
cacagtgcta cagactggaa caaaaacc                                    28

<210> 78
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 78
cacagtggta gtactccact gtctggctgt tgtctctga                        39

<210> 79
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 79
cagagtgctc cagggctgaa caaaaacc                                    28

<210> 80
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 80
cacagtggta gtactccact gtctgggtgt acaaaaacc                        39

<210> 81
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 81
cacagtgctc cagggctgaa aaaaaacc                                    28

<210> 82
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 82
cacagtggta gtactccact gtctgggtgt acaaaaacc                        39

<210> 83
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 83
ctcagtgctc cagggctgaa caaaaacc                                    28

<210> 84
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recombination signal sequence

<400> 84
cacagtggta gtactccact gtctgggtgt acaaaaacc                        39

<210> 85
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 85
ggtacaactg gaacgac                                                17

<210> 86
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 86
ggtataactg gaactac                                                17

<210> 87
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 87
ggtataactg gaacgac                                                17

<210> 88
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 88
ggtatagtgg gagctactac                                             20

<210> 89
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 89
aggatattgt agtagtacca gctgctatac c                                31

<210> 90
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 90
aggatattgt actaatggtg tatgctatac c                                31

<210> 91
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 91
aggatattgt agtggtggta gctgctactc c                                31

<210> 92
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 92
agcatattgt ggtggtgact gctattcc                                    28

<210> 93
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 93
gtattacgat ttttggagtg gttattatac c                                31

<210> 94
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 94
gtattacgat attttgactg gttattataa c                                31

<210> 95
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 95
gtattactat ggttcgggga gttattataa c                                31

<210> 96
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 96
gtattatgat tacgtttggg ggagttatcg ttatacc                          37

<210> 97
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 97
gtattactat gatagtagtg gttattacta c                                31

<210> 98
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 98
tgactacagt aactac                                                 16

<210> 99
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 99
tgactacagt aactac                                                 16

<210> 100
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 100
tgactacggt gactac                                                 16

<210> 101
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 101
tgactacggt ggtaactcc                                              19

<210> 102
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 102
gtggatacag ctatggttac                                             20

<210> 103
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 103
gtggatatag tggctacgat tac                                         23

<210> 104
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 104
gtggatacag ctatggttac                                             20

<210> 105
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 105
gtagagatgg ctacaattac                                             20

<210> 106
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 106
gagtatagca gctcgtcc                                               18

<210> 107
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 107
gggtatagca gcagctggta c                                           21

<210> 108
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 108
gggtatagca gtggctggta c                                           21

<210> 109
<211> 11
<212> DNA
<213> Artificial Sequence

<220> 
<223> D segment encoding sequence

<400> 109
ctaactgggg a                                                      11
