                               SEQUENCE LISTING

<110> IBC PHARMACEUTICALS, INC.
 
<120> MODULAR METHOD TO PREPARE TETRAMERIC CYTOKINES WITH IMPROVED 
      PHARMACOKINETICS BY THE DOCK-AND-LOCK (DNL) TECHNOLOGY

<130> IBC120WO1

<140>
<141>

<150> 12/396,965
<151> 2009-03-03

<150> 12/396,605
<151> 2009-03-03

<150> 61/119,542
<151> 2008-12-03

<150> 61/104,916
<151> 2008-10-13

<150> 61/043,932
<151> 2008-04-10

<150> 11/925,408
<151> 2007-10-26

<150> 11/745,692
<151> 2007-05-08

<150> 11/633,729
<151> 2006-12-05

<150> 60/864,530
<151> 2006-11-06

<150> 11/478,021
<151> 2006-06-29

<150> 60/800,342
<151> 2006-05-15

<150> 11/391,584
<151> 2006-03-28

<150> 11/389,358
<151> 2006-03-24

<150> 60/782,332
<151> 2006-03-14

<150> 60/751,196
<151> 2005-12-16

<150> 60/728,292
<151> 2005-10-20

<150> 60/668,603
<151> 2005-04-06

<160> 28    

<170> PatentIn version 3.5

<210> 1
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 1
agatctggcg cacctgaact cctg                                              24


<210> 2
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 2
gaattcggat cctttacccg gagacaggga gag                                    33


<210> 3
<211> 63
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 3
Lys Ser His His His His His His Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Cys Gly His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu 
            20                  25                  30          


Gln Gly Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val 
        35                  40                  45              


Glu Phe Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
    50                  55                  60              


<210> 4
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 4
tctagacaca ggacctcatc atggccttga cctttgcttt actgg                       45


<210> 5
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 5
ggatccatga tggtgatgat ggtgtgactt ttccttactt cttaaacttt cttgc            55


<210> 6
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 6
tctagacaca ggacctcatc atgggggtgc acgaatgtcc                             40


<210> 7
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 7
ggatccatga tggtgatgat ggtgtgactt tctgtcccct gtcctgcag                   49


<210> 8
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 8
tctagacaca ggacctcatc atggctggac ctgccaccca g                           41


<210> 9
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 9
ggatccatga tggtgatgat ggtgtgactt gggctgggca aggtggcgta g                51


<210> 10
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 10
Cys Gly His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly 
1               5                   10                  15      


Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe 
            20                  25                  30          


Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  45  


<210> 11
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 11
Cys Gly Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile 
1               5                   10                  15      


Gln Gln Ala Gly Cys 
            20      


<210> 12
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 12
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 13
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 13
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 14
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 14
Gln Ile Glu Tyr Val Ala Lys Gln Ile Val Asp Tyr Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 15
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 15
Gln Ile Glu Tyr Lys Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 16
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 16
Gln Ile Glu Tyr His Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 17
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 17
Gln Ile Glu Tyr Val Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 18
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 18
Asp Leu Ile Glu Glu Ala Ala Ser Arg Ile Val Asp Ala Val Ile Glu 
1               5                   10                  15      


Gln Val Lys Ala Ala Gly Ala Tyr 
            20                  


<210> 19
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 19
Leu Glu Gln Tyr Ala Asn Gln Leu Ala Asp Gln Ile Ile Lys Glu Ala 
1               5                   10                  15      


Thr Glu 
        


<210> 20
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 20
Phe Glu Glu Leu Ala Trp Lys Ile Ala Lys Met Ile Trp Ser Asp Val 
1               5                   10                  15      


Phe Gln Gln Cys 
            20  


<210> 21
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 21
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Leu Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 22
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 22
Pro Glu Asp Ala Glu Leu Val Arg Thr Ser Lys Arg Leu Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 23
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 23
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Asp Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 24
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 24
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
1               5                   10  


<210> 25
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 25
Gln Lys Ser Leu Ser Leu Ser Pro Gly Leu Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Cys Gly 
            20      


<210> 26
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 26
Gln Lys Ser Leu Ser Leu Ser Pro Gly Ala Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Cys Gly 
            20      


<210> 27
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 27
Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Cys Gly 
            20  


<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 6xHis tag

<400> 28
His His His His His His 
1               5       


