                         SEQUENCE LISTING

<110>  UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
       INSECTIGEN, INC.
 
<120>  NOVEL PROTEIN FOR BINDING BACILLUS THURINGIENSIS CRY TOXINS, AND 
       FRAGMENTS OF CADHERINS FOR ENHANCING CRY TOXICITY AGAINST 
       DIPTERANS

<130>  UGR-108

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  5208
<212>  DNA
<213>  Anopheles gambiae

<400>  1
atgaaatgtg ttgctagtaa atttaacatg tggttgcact tgggttggtt gctggggttg       60

ctgctggtcc tgttgccgtt ggtccgatgc caaggatggg gcgaaccacg gttcgagacg      120

ggaaatgtgg aaaatatatc cctcgccgca tacaacgagg cgcagcttca gcaagatgtc      180

tggatggtgg aggagatgga tgcaccgttc gtgctgctct acatcaatta ccaaggaccg      240

tccgagccta cgatacgcga gtcaccggcc gatcttgacg caaggctaca gctgtccgag      300

ggtggccgct ggtcgatcgt aatcaatcgc cggcaggact acgaggtgca tcagcgtagc      360

agtctcattc tgctggccgt cgaatccacg gctatcccgt acgcgatcgt ggtcaacttg      420

gtgaacgtgc tggacaatgc gcccgtcatg acggcccaag gtagctgtga gattgaggag      480

ttgcgcgggg actttgtgac ggactgtctg tttaacgtgt accatgcgga cgggttcgag      540

gagaatggca ttggcaattc gagcacgaac gagctgtcgt tcgagatcgg tgatgtggcc      600

ggtgcgcggg accactttac gtacgtgccc tccacggtga ccccttccca gccgatctac      660

aacaagctgt tcaatttgaa agttttaaag cagctggact acaccgagaa cgctatattt      720

aacttcatca ccactgtgta cgacctagac cggacgcact ctttcaagat gagtacgatc      780

gttcaggtac gcaacgtcga tagccggcct ccgatcttta gccgaccgtt caccagcgaa      840

cgaatcatgg aaaaggaacc attttacgcg accgtgatcg caatcgaccg agacactgga      900

ctaaacaaac cgatctgtta cgagctgacg gctctagtcc cggaatatca gaaatatttc      960

gaaattggac aaactgatgg aaagctgacc gtgcacccga ttgatcgaga tgcggaacag     1020

aacgagctgt acacctttac gattgtagcg tacaagtgtc acaaccggct gctgaacacc     1080

tccagcgagg gtgcaatcat tttgctggac aaaaatgaca acattcccga aatatacatg     1140

aagccgcttg agctggagtt ttgggaaaac accatcatgg agctgccatt cgacgagctc     1200

gtcattcacg atcgcgatct cggcgagaat gcccggtacg aggtgcggct ggccgaaacg     1260

gtagcaggcg tacagcagac agcggactcg ttcaccatca tccctggcaa cgggtaccag     1320

cgtgtatcgt tcacgatcaa catcaacaat gcgaccagcc tggactatga gctgccggag     1380

cgtcaaacgt ttgtgctgca cgttaccgct cacgaaccga tcgaaccgac gcacgaaagc     1440

acccagccga ttacgattcg gctcaaaaac tggaacgatg aggtaccgaa gtttggccgc     1500

gatgagtacc agatcagcgt gcccgaaacg atcggagcgg gcgagctgtt ggcaacgatc     1560

accgtgaccg atcgcgacat agacgatggt attaagctgt ccgcactggg acggttggct     1620

gaaagtttaa gcgtcaccga gctgccggtc agtgccgagc ccgagactaa cctccccctg     1680

tacgggttcg aaatcactac caaggtggga gacatcttcg actacgatat tgcgaaagag     1740

gtgatagtgc agctgcaggc tgaagatacg ctgcgcacgg ctaaacaaga aagcctgcat     1800

cagatcttct cgcagctaac catcacggtg atagacgtga acaataagcc gccccaaatt     1860

acgctgcctc gcggtacgat gcacattttg gaaaactcgg tcgccgacag tgcggttatc     1920

attggcgagg agcagatagc acagatcatc ggcacagatc ccgacaccga ggcggagctg     1980

gagtttagta tcgattggag caacagctac ggcaccaaga gcggaatccg ggcgaaggcg     2040

gaaacatacg aaaactgttt ctacatacac gaggaaaagg taaaccgtca gcgaacgatc     2100

ggaaccatcc gtgtgaatcc cacgttcccc ctggacgtcg atcacgaaat gtacgacaca     2160

ctgttcctgg tcattcggct ggtggaccgg aatcagacga tcctgcccaa cacggtggaa     2220

actgtagtgg cgatacagat tgacgatgag aacgataatg ctccttactt tgacaacagc     2280

acgctcacgg tggtacggtc ggttaaggaa cgatcggact cgggcgtaac gatcggtaac     2340

atcatcgctc acgacattga cggaccagga aataacgaaa taacgttcgc gatggaacca     2400

atcgatccgg cccacaaagg atggatgaac attgacgaca acggtaccgt aagggtggag     2460

ggcaatcgat cgatcgactg tgacatcccg cccatcgaca aggtgctaca gaacgtaacc     2520

atatcggact ggaagtggag taactggcac gtgtttgaaa ttgtcctgat ggacaccaac     2580

aacaagcagc cgtatcacga tcccttcccg aacgatgggc aggtgtacca gtttgagaaa     2640

ataccctcca atacagccat cgtgcgggtg gagggcaaag atcaggatcg cgatgtcccg     2700

taccataccg tgtcgtacga gatcaactat cgggattttc cgcagctgca gcgttacttc     2760

gaggtggaca gtaccgggcg ggcgtacgtg aaggaaaaca acgatctgct cgatcgagat     2820

gcgggtcttg agagcattat gattaacatc gtgatgctgg ataatgcggg cggatatgac     2880

attcaaaatc gtgtatcgac aaacatcaat ctcactctgc tcgacatcaa cgatcatacg     2940

ccaaagctac cggagctggc agcggacgaa ctgaaggtgt cggagaacgc caagcagggc     3000

tacatcgtaa agacaccctt tgctgcactt gacctagatg acaagcgtac gccaaatgca     3060

aagatcaact actacatcga agagatgacg ccagagccgg aaactcccct attctcgcta     3120

gaaaatatag acgaatacaa tgcggtgcca agggtggctc aagatctgaa aggattttac     3180

ggaacgtgga cactgaaaat taaggcctgt gatcgtggca gtgagtacga accaataatt     3240

ccactaacgg aagaaccgaa ggacaattgc gaaacacgcg actacgagct gacggtggaa     3300

ccgttcaact acaacactcc cagcattacc tacccctccc gtagcgcaca gctccgtcta     3360

aagtacgaat cgctacaaaa cggacgcccg ctggtcgaga ctaatgggtc cccgttgccg     3420

aaattcgaag ccatcgatga tgatggtggc atatatggag acgtaacgtt ttcactgacc     3480

agcacaaatg acggtgagca ggaccacgaa gtgttccggg tggataaagt tgacaacaaa     3540

acgggcctgc tagtgttgga aaattcgctc gccgtacaac cgttcccgaa aaactacagc     3600

atcaccgtga ttgccaggga tggcggtgac aggcagtcgg aagccgctat tcacgtcgtc     3660

ttcatcaaca tgacgggcga gccggccttt ctggagccga ccttcgatac ggactttaca     3720

gaaaatgaag agggtcgcga tgagagacgg cagctaccgt ttgccgagga tccgaagaac     3780

gcgggccttc ccccgggcgc tgagacgaac gtgtactatt tcatcgataa gacgtacggt     3840

aatgcgagcc atctgtttca actggaccgc gtcagcaatg tgctgcagct ggcccagctg     3900

ctcgaccggg aagagatacc gacgcccgaa atccgaatcg tggccaccaa caacgaaaat     3960

agcccgccgg atacggtgct cgaatcgtcc ccctcgctgc tggtcgtccg catcaaggtg     4020

aacgatgtga acgacaatcc gccggtgttt cagcagcggc tgtacgccgc cggcatcacc     4080

acgaacgacc gcgtcccgaa ggcactgttt cgcgtgtacg ccgaagatcc ggacgaggac     4140

gaaatcatcc ggtacgagtt ggtgaacggg acggcggtcg gtgaaaacct gcaaacggac     4200

gggctgccct tccggctcca tccggacagt ggagagctaa cgctgacgtc caaggtacag     4260

ccgaaccaga acgggtacta tcagctcacc ctgatcgcgt tcgatcggga cgatacgcac     4320

aatgatacgg tgccggccaa ggtgtacatc gtgtcggaat cgaaccgcgt gacgttcgtg     4380

tttctgaaca gcgtcgagga gattgatcaa ccggacgtgc ggaagtttct tgcccaagag     4440

ctgaccggtg cgtacgaaat ggaatgcaac atcgacgaca tcgaccagac gacggcgagc     4500

gacggtagac aggccggggg gtctagcagc gccctcacgg acgttcggac ccacttcatc     4560

caggacaatc aggcggtgga ggcgagccgg atacagcagc gatcctcgaa ccggacgttc     4620

gtcaccgtgc tcaagacgac gctgcgcact cgcggcctct ccctgcagga cgtaccgccc     4680

ctggcgacgg aagcgctgac cgaggcggac gaaacgctgc agatcatcct gattgtggta     4740

tcggcggccc tagccgtcct gtgcgtgata ctgttcgtgg cgttcttcat caagatccgc     4800

agcctaaatc gccagctgaa ggccctgtcc gcgaccgatt ttgggtcgat ttcgtccgag     4860

ctgaatggga agccgacgcg caacgtgccc acaacgaaca tcttctcgat cgagggctcc     4920

aatccggtgc ttaacgataa cgagttccga gaccggatgg gtggtggtgg tggcggtgtt     4980

tatgacgatc tcagtctaca atcggaagaa tccgacttca acgacgtgga cagggacatt     5040

ttcgcaccga agcgaaagga gagtcttaat cccgcgctcc tggagcacat acgccagcgt     5100

tcgctaaacc caatggcgaa cggaaccgac aagagcaacg acggtgcgcc tacctccaac     5160

cataaaaagc tcgacgaaac tgacgacgag ctgtcccacc ggttctag                  5208


<210>  2
<211>  1735
<212>  PRT
<213>  Anopheles gambiae

<400>  2

Met Lys Cys Val Ala Ser Lys Phe Asn Met Trp Leu His Leu Gly Trp 
1               5                   10                  15      


Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Leu Val Arg Cys Gln Gly 
            20                  25                  30          


Trp Gly Glu Pro Arg Phe Glu Thr Gly Asn Val Glu Asn Ile Ser Leu 
        35                  40                  45              


Ala Ala Tyr Asn Glu Ala Gln Leu Gln Gln Asp Val Trp Met Val Glu 
    50                  55                  60                  


Glu Met Asp Ala Pro Phe Val Leu Leu Tyr Ile Asn Tyr Gln Gly Pro 
65                  70                  75                  80  


Ser Glu Pro Thr Ile Arg Glu Ser Pro Ala Asp Leu Asp Ala Arg Leu 
                85                  90                  95      


Gln Leu Ser Glu Gly Gly Arg Trp Ser Ile Val Ile Asn Arg Arg Gln 
            100                 105                 110         


Asp Tyr Glu Val His Gln Arg Ser Ser Leu Ile Leu Leu Ala Val Glu 
        115                 120                 125             


Ser Thr Ala Ile Pro Tyr Ala Ile Val Val Asn Leu Val Asn Val Leu 
    130                 135                 140                 


Asp Asn Ala Pro Val Met Thr Ala Gln Gly Ser Cys Glu Ile Glu Glu 
145                 150                 155                 160 


Leu Arg Gly Asp Phe Val Thr Asp Cys Leu Phe Asn Val Tyr His Ala 
                165                 170                 175     


Asp Gly Phe Glu Glu Asn Gly Ile Gly Asn Ser Ser Thr Asn Glu Leu 
            180                 185                 190         


Ser Phe Glu Ile Gly Asp Val Ala Gly Ala Arg Asp His Phe Thr Tyr 
        195                 200                 205             


Val Pro Ser Thr Val Thr Pro Ser Gln Pro Ile Tyr Asn Lys Leu Phe 
    210                 215                 220                 


Asn Leu Lys Val Leu Lys Gln Leu Asp Tyr Thr Glu Asn Ala Ile Phe 
225                 230                 235                 240 


Asn Phe Ile Thr Thr Val Tyr Asp Leu Asp Arg Thr His Ser Phe Lys 
                245                 250                 255     


Met Ser Thr Ile Val Gln Val Arg Asn Val Asp Ser Arg Pro Pro Ile 
            260                 265                 270         


Phe Ser Arg Pro Phe Thr Ser Glu Arg Ile Met Glu Lys Glu Pro Phe 
        275                 280                 285             


Tyr Ala Thr Val Ile Ala Ile Asp Arg Asp Thr Gly Leu Asn Lys Pro 
    290                 295                 300                 


Ile Cys Tyr Glu Leu Thr Ala Leu Val Pro Glu Tyr Gln Lys Tyr Phe 
305                 310                 315                 320 


Glu Ile Gly Gln Thr Asp Gly Lys Leu Thr Val His Pro Ile Asp Arg 
                325                 330                 335     


Asp Ala Glu Gln Asn Glu Leu Tyr Thr Phe Thr Ile Val Ala Tyr Lys 
            340                 345                 350         


Cys His Asn Arg Leu Leu Asn Thr Ser Ser Glu Gly Ala Ile Ile Leu 
        355                 360                 365             


Leu Asp Lys Asn Asp Asn Ile Pro Glu Ile Tyr Met Lys Pro Leu Glu 
    370                 375                 380                 


Leu Glu Phe Trp Glu Asn Thr Ile Met Glu Leu Pro Phe Asp Glu Leu 
385                 390                 395                 400 


Val Ile His Asp Arg Asp Leu Gly Glu Asn Ala Arg Tyr Glu Val Arg 
                405                 410                 415     


Leu Ala Glu Thr Val Ala Gly Val Gln Gln Thr Ala Asp Ser Phe Thr 
            420                 425                 430         


Ile Ile Pro Gly Asn Gly Tyr Gln Arg Val Ser Phe Thr Ile Asn Ile 
        435                 440                 445             


Asn Asn Ala Thr Ser Leu Asp Tyr Glu Leu Pro Glu Arg Gln Thr Phe 
    450                 455                 460                 


Val Leu His Val Thr Ala His Glu Pro Ile Glu Pro Thr His Glu Ser 
465                 470                 475                 480 


Thr Gln Pro Ile Thr Ile Arg Leu Lys Asn Trp Asn Asp Glu Val Pro 
                485                 490                 495     


Lys Phe Gly Arg Asp Glu Tyr Gln Ile Ser Val Pro Glu Thr Ile Gly 
            500                 505                 510         


Ala Gly Glu Leu Leu Ala Thr Ile Thr Val Thr Asp Arg Asp Ile Asp 
        515                 520                 525             


Asp Gly Ile Lys Leu Ser Ala Leu Gly Arg Leu Ala Glu Ser Leu Ser 
    530                 535                 540                 


Val Thr Glu Leu Pro Val Ser Ala Glu Pro Glu Thr Asn Leu Pro Leu 
545                 550                 555                 560 


Tyr Gly Phe Glu Ile Thr Thr Lys Val Gly Asp Ile Phe Asp Tyr Asp 
                565                 570                 575     


Ile Ala Lys Glu Val Ile Val Gln Leu Gln Ala Glu Asp Thr Leu Arg 
            580                 585                 590         


Thr Ala Lys Gln Glu Ser Leu His Gln Ile Phe Ser Gln Leu Thr Ile 
        595                 600                 605             


Thr Val Ile Asp Val Asn Asn Lys Pro Pro Gln Ile Thr Leu Pro Arg 
    610                 615                 620                 


Gly Thr Met His Ile Leu Glu Asn Ser Val Ala Asp Ser Ala Val Ile 
625                 630                 635                 640 


Ile Gly Glu Glu Gln Ile Ala Gln Ile Ile Gly Thr Asp Pro Asp Thr 
                645                 650                 655     


Glu Ala Glu Leu Glu Phe Ser Ile Asp Trp Ser Asn Ser Tyr Gly Thr 
            660                 665                 670         


Lys Ser Gly Ile Arg Ala Lys Ala Glu Thr Tyr Glu Asn Cys Phe Tyr 
        675                 680                 685             


Ile His Glu Glu Lys Val Asn Arg Gln Arg Thr Ile Gly Thr Ile Arg 
    690                 695                 700                 


Val Asn Pro Thr Phe Pro Leu Asp Val Asp His Glu Met Tyr Asp Thr 
705                 710                 715                 720 


Leu Phe Leu Val Ile Arg Leu Val Asp Arg Asn Gln Thr Ile Leu Pro 
                725                 730                 735     


Asn Thr Val Glu Thr Val Val Ala Ile Gln Ile Asp Asp Glu Asn Asp 
            740                 745                 750         


Asn Ala Pro Tyr Phe Asp Asn Ser Thr Leu Thr Val Val Arg Ser Val 
        755                 760                 765             


Lys Glu Arg Ser Asp Ser Gly Val Thr Ile Gly Asn Ile Ile Ala His 
    770                 775                 780                 


Asp Ile Asp Gly Pro Gly Asn Asn Glu Ile Thr Phe Ala Met Glu Pro 
785                 790                 795                 800 


Ile Asp Pro Ala His Lys Gly Trp Met Asn Ile Asp Asp Asn Gly Thr 
                805                 810                 815     


Val Arg Val Glu Gly Asn Arg Ser Ile Asp Cys Asp Ile Pro Pro Ile 
            820                 825                 830         


Asp Lys Val Leu Gln Asn Val Thr Ile Ser Asp Trp Lys Trp Ser Asn 
        835                 840                 845             


Trp His Val Phe Glu Ile Val Leu Met Asp Thr Asn Asn Lys Gln Pro 
    850                 855                 860                 


Tyr His Asp Pro Phe Pro Asn Asp Gly Gln Val Tyr Gln Phe Glu Lys 
865                 870                 875                 880 


Ile Pro Ser Asn Thr Ala Ile Val Arg Val Glu Gly Lys Asp Gln Asp 
                885                 890                 895     


Arg Asp Val Pro Tyr His Thr Val Ser Tyr Glu Ile Asn Tyr Arg Asp 
            900                 905                 910         


Phe Pro Gln Leu Gln Arg Tyr Phe Glu Val Asp Ser Thr Gly Arg Ala 
        915                 920                 925             


Tyr Val Lys Glu Asn Asn Asp Leu Leu Asp Arg Asp Ala Gly Leu Glu 
    930                 935                 940                 


Ser Ile Met Ile Asn Ile Val Met Leu Asp Asn Ala Gly Gly Tyr Asp 
945                 950                 955                 960 


Ile Gln Asn Arg Val Ser Thr Asn Ile Asn Leu Thr Leu Leu Asp Ile 
                965                 970                 975     


Asn Asp His Thr Pro Lys Leu Pro Glu Leu Ala Ala Asp Glu Leu Lys 
            980                 985                 990         


Val Ser Glu Asn Ala Lys Gln Gly  Tyr Ile Val Lys Thr  Pro Phe Ala 
        995                 1000                 1005             


Ala Leu  Asp Leu Asp Asp Lys  Arg Thr Pro Asn Ala  Lys Ile Asn 
    1010                 1015                 1020             


Tyr Tyr  Ile Glu Glu Met Thr  Pro Glu Pro Glu Thr  Pro Leu Phe 
    1025                 1030                 1035             


Ser Leu  Glu Asn Ile Asp Glu  Tyr Asn Ala Val Pro  Arg Val Ala 
    1040                 1045                 1050             


Gln Asp  Leu Lys Gly Phe Tyr  Gly Thr Trp Thr Leu  Lys Ile Lys 
    1055                 1060                 1065             


Ala Cys  Asp Arg Gly Ser Glu  Tyr Glu Pro Ile Ile  Pro Leu Thr 
    1070                 1075                 1080             


Glu Glu  Pro Lys Asp Asn Cys  Glu Thr Arg Asp Tyr  Glu Leu Thr 
    1085                 1090                 1095             


Val Glu  Pro Phe Asn Tyr Asn  Thr Pro Ser Ile Thr  Tyr Pro Ser 
    1100                 1105                 1110             


Arg Ser  Ala Gln Leu Arg Leu  Lys Tyr Glu Ser Leu  Gln Asn Gly 
    1115                 1120                 1125             


Arg Pro  Leu Val Glu Thr Asn  Gly Ser Pro Leu Pro  Lys Phe Glu 
    1130                 1135                 1140             


Ala Ile  Asp Asp Asp Gly Gly  Ile Tyr Gly Asp Val  Thr Phe Ser 
    1145                 1150                 1155             


Leu Thr  Ser Thr Asn Asp Gly  Glu Gln Asp His Glu  Val Phe Arg 
    1160                 1165                 1170             


Val Asp  Lys Val Asp Asn Lys  Thr Gly Leu Leu Val  Leu Glu Asn 
    1175                 1180                 1185             


Ser Leu  Ala Val Gln Pro Phe  Pro Lys Asn Tyr Ser  Ile Thr Val 
    1190                 1195                 1200             


Ile Ala  Arg Asp Gly Gly Asp  Arg Gln Ser Glu Ala  Ala Ile His 
    1205                 1210                 1215             


Val Val  Phe Ile Asn Met Thr  Gly Glu Pro Ala Phe  Leu Glu Pro 
    1220                 1225                 1230             


Thr Phe  Asp Thr Asp Phe Thr  Glu Asn Glu Glu Gly  Arg Asp Glu 
    1235                 1240                 1245             


Arg Arg  Gln Leu Pro Phe Ala  Glu Asp Pro Lys Asn  Ala Gly Leu 
    1250                 1255                 1260             


Pro Pro  Gly Ala Glu Thr Asn  Val Tyr Tyr Phe Ile  Asp Lys Thr 
    1265                 1270                 1275             


Tyr Gly  Asn Ala Ser His Leu  Phe Gln Leu Asp Arg  Val Ser Asn 
    1280                 1285                 1290             


Val Leu  Gln Leu Ala Gln Leu  Leu Asp Arg Glu Glu  Ile Pro Thr 
    1295                 1300                 1305             


Pro Glu  Ile Arg Ile Val Ala  Thr Asn Asn Glu Asn  Ser Pro Pro 
    1310                 1315                 1320             


Asp Thr  Val Leu Glu Ser Ser  Pro Ser Leu Leu Val  Val Arg Ile 
    1325                 1330                 1335             


Lys Val  Asn Asp Val Asn Asp  Asn Pro Pro Val Phe  Gln Gln Arg 
    1340                 1345                 1350             


Leu Tyr  Ala Ala Gly Ile Thr  Thr Asn Asp Arg Val  Pro Lys Ala 
    1355                 1360                 1365             


Leu Phe  Arg Val Tyr Ala Glu  Asp Pro Asp Glu Asp  Glu Ile Ile 
    1370                 1375                 1380             


Arg Tyr  Glu Leu Val Asn Gly  Thr Ala Val Gly Glu  Asn Leu Gln 
    1385                 1390                 1395             


Thr Asp  Gly Leu Pro Phe Arg  Leu His Pro Asp Ser  Gly Glu Leu 
    1400                 1405                 1410             


Thr Leu  Thr Ser Lys Val Gln  Pro Asn Gln Asn Gly  Tyr Tyr Gln 
    1415                 1420                 1425             


Leu Thr  Leu Ile Ala Phe Asp  Arg Asp Asp Thr His  Asn Asp Thr 
    1430                 1435                 1440             


Val Pro  Ala Lys Val Tyr Ile  Val Ser Glu Ser Asn  Arg Val Thr 
    1445                 1450                 1455             


Phe Val  Phe Leu Asn Ser Val  Glu Glu Ile Asp Gln  Pro Asp Val 
    1460                 1465                 1470             


Arg Lys  Phe Leu Ala Gln Glu  Leu Thr Gly Ala Tyr  Glu Met Glu 
    1475                 1480                 1485             


Cys Asn  Ile Asp Asp Ile Asp  Gln Thr Thr Ala Ser  Asp Gly Arg 
    1490                 1495                 1500             


Gln Ala  Gly Gly Ser Ser Ser  Ala Leu Thr Asp Val  Arg Thr His 
    1505                 1510                 1515             


Phe Ile  Gln Asp Asn Gln Ala  Val Glu Ala Ser Arg  Ile Gln Gln 
    1520                 1525                 1530             


Arg Ser  Ser Asn Arg Thr Phe  Val Thr Val Leu Lys  Thr Thr Leu 
    1535                 1540                 1545             


Arg Thr  Arg Gly Leu Ser Leu  Gln Asp Val Pro Pro  Leu Ala Thr 
    1550                 1555                 1560             


Glu Ala  Leu Thr Glu Ala Asp  Glu Thr Leu Gln Ile  Ile Leu Ile 
    1565                 1570                 1575             


Val Val  Ser Ala Ala Leu Ala  Val Leu Cys Val Ile  Leu Phe Val 
    1580                 1585                 1590             


Ala Phe  Phe Ile Lys Ile Arg  Ser Leu Asn Arg Gln  Leu Lys Ala 
    1595                 1600                 1605             


Leu Ser  Ala Thr Asp Phe Gly  Ser Ile Ser Ser Glu  Leu Asn Gly 
    1610                 1615                 1620             


Lys Pro  Thr Arg Asn Val Pro  Thr Thr Asn Ile Phe  Ser Ile Glu 
    1625                 1630                 1635             


Gly Ser  Asn Pro Val Leu Asn  Asp Asn Glu Phe Arg  Asp Arg Met 
    1640                 1645                 1650             


Gly Gly  Gly Gly Gly Gly Val  Tyr Asp Asp Leu Ser  Leu Gln Ser 
    1655                 1660                 1665             


Glu Glu  Ser Asp Phe Asn Asp  Val Asp Arg Asp Ile  Phe Ala Pro 
    1670                 1675                 1680             


Lys Arg  Lys Glu Ser Leu Asn  Pro Ala Leu Leu Glu  His Ile Arg 
    1685                 1690                 1695             


Gln Arg  Ser Leu Asn Pro Met  Ala Asn Gly Thr Asp  Lys Ser Asn 
    1700                 1705                 1710             


Asp Gly  Ala Pro Thr Ser Asn  His Lys Lys Leu Asp  Glu Thr Asp 
    1715                 1720                 1725             


Asp Glu  Leu Ser His Arg Phe  
    1730                 1735 


<210>  3
<211>  636
<212>  DNA
<213>  Anopheles gambiae

<400>  3
ggcatcacca cgaacgaccg cgtcccgaag gcactgtttc gcgtgtacgc cgaagatccg       60

gacgaggacg aaatcatccg gtacgagttg gtgaacggga cggcggtcgg tgaaaacctg      120

caaacggacg ggctgccctt ccggctccat ccggacagtg gagagctaac gctgacgtcc      180

aaggtacagc cgaaccagaa cgggtactat cagctcaccc tgatcgcgtt cgatcgggac      240

gatacgcaca atgatacggt gccggccaag gtgtacatcg tgtcggaatc gaaccgcgtg      300

acgttcgtgt ttctgaacag cgtcgaggag attgatcaac cggacgtgcg gaagtttctt      360

gcccaagagc tgaccggtgc gtacgaaatg gaatgcaaca tcgacgacat cgaccagacg      420

acggcgagcg acggtagaca ggccgggggg tctagcagcg ccctcacgga cgttcggacc      480

cacttcatcc aggacaatca ggcggtggag gcgagccgga tacagcagcg atcctcgaac      540

cggacgttcg tcaccgtgct caagacgacg ctgcgcactc gcggcctctc cctgcaggac      600

gtaccgcccc tggcgacgga agcgctgacc gaggcg                                636


<210>  4
<211>  212
<212>  PRT
<213>  Anopheles gambiae

<400>  4

Gly Ile Thr Thr Asn Asp Arg Val Pro Lys Ala Leu Phe Arg Val Tyr 
1               5                   10                  15      


Ala Glu Asp Pro Asp Glu Asp Glu Ile Ile Arg Tyr Glu Leu Val Asn 
            20                  25                  30          


Gly Thr Ala Val Gly Glu Asn Leu Gln Thr Asp Gly Leu Pro Phe Arg 
        35                  40                  45              


Leu His Pro Asp Ser Gly Glu Leu Thr Leu Thr Ser Lys Val Gln Pro 
    50                  55                  60                  


Asn Gln Asn Gly Tyr Tyr Gln Leu Thr Leu Ile Ala Phe Asp Arg Asp 
65                  70                  75                  80  


Asp Thr His Asn Asp Thr Val Pro Ala Lys Val Tyr Ile Val Ser Glu 
                85                  90                  95      


Ser Asn Arg Val Thr Phe Val Phe Leu Asn Ser Val Glu Glu Ile Asp 
            100                 105                 110         


Gln Pro Asp Val Arg Lys Phe Leu Ala Gln Glu Leu Thr Gly Ala Tyr 
        115                 120                 125             


Glu Met Glu Cys Asn Ile Asp Asp Ile Asp Gln Thr Thr Ala Ser Asp 
    130                 135                 140                 


Gly Arg Gln Ala Gly Gly Ser Ser Ser Ala Leu Thr Asp Val Arg Thr 
145                 150                 155                 160 


His Phe Ile Gln Asp Asn Gln Ala Val Glu Ala Ser Arg Ile Gln Gln 
                165                 170                 175     


Arg Ser Ser Asn Arg Thr Phe Val Thr Val Leu Lys Thr Thr Leu Arg 
            180                 185                 190         


Thr Arg Gly Leu Ser Leu Gln Asp Val Pro Pro Leu Ala Thr Glu Ala 
        195                 200                 205             


Leu Thr Glu Ala 
    210         


<210>  5
<211>  978
<212>  DNA
<213>  Anopheles gambiae

<400>  5
gggtccccgt tgccgaaatt cgaagccatc gatgatgatg gtggcatata tggagacgta       60

acgttttcac tgaccagcac aaatgacggt gagcaggacc acgaagtgtt ccgggtggat      120

aaagttgaca acaaaacggg cctgctagtg ttggaaaatt cgctcgccgt acaaccgttc      180

ccgaaaaact acagcatcac cgtgattgcc agggatggcg gtgacaggca gtcggaagcc      240

gctattcacg tcgtcttcat caacatgacg ggcgagccgg cctttctgga gccgaccttc      300

gatacggact ttacagaaaa tgaagagggt cgcgatgaga gacggcagct accgtttgcc      360

gaggatccga agaacgcggg ccttcccccg ggcgctgaga cgaacgtgta ctatttcatc      420

gataagacgt acggtaatgc gagccatctg tttcaactgg accgcgtcag caatgtgctg      480

cagctggccc agctgctcga ccgggaagag ataccgacgc ccgaaatccg aatcgtggcc      540

accaacaacg aaaatagccc gccggatacg gtgctcgaat cgtccccctc gctgctggtc      600

gtccgcatca aggtgaacga tgtgaacgac aatccgccgg tgtttcagca gcggctgtac      660

gccgccggca tcaccacgaa cgaccgcgtc ccgaaggcac tgtttcgcgt gtacgccgaa      720

gatccggacg aggacgaaat catccggtac gagttggtga acgggacggc ggtcggtgaa      780

aacctgcaaa cggacgggct gcccttccgg ctccatccgg acagtggaga gctaacgctg      840

acgtccaagg tacagccgaa ccagaacggg tactatcagc tcaccctgat cgcgttcgat      900

cgggacgata cgcacaatga tacggtgccg gccaaggtgt acatcgtgtc ggaatcgaac      960

cgcgtgacgt tcgtgttt                                                    978


<210>  6
<211>  326
<212>  PRT
<213>  Anopheles gambiae

<400>  6

Gly Ser Pro Leu Pro Lys Phe Glu Ala Ile Asp Asp Asp Gly Gly Ile 
1               5                   10                  15      


Tyr Gly Asp Val Thr Phe Ser Leu Thr Ser Thr Asn Asp Gly Glu Gln 
            20                  25                  30          


Asp His Glu Val Phe Arg Val Asp Lys Val Asp Asn Lys Thr Gly Leu 
        35                  40                  45              


Leu Val Leu Glu Asn Ser Leu Ala Val Gln Pro Phe Pro Lys Asn Tyr 
    50                  55                  60                  


Ser Ile Thr Val Ile Ala Arg Asp Gly Gly Asp Arg Gln Ser Glu Ala 
65                  70                  75                  80  


Ala Ile His Val Val Phe Ile Asn Met Thr Gly Glu Pro Ala Phe Leu 
                85                  90                  95      


Glu Pro Thr Phe Asp Thr Asp Phe Thr Glu Asn Glu Glu Gly Arg Asp 
            100                 105                 110         


Glu Arg Arg Gln Leu Pro Phe Ala Glu Asp Pro Lys Asn Ala Gly Leu 
        115                 120                 125             


Pro Pro Gly Ala Glu Thr Asn Val Tyr Tyr Phe Ile Asp Lys Thr Tyr 
    130                 135                 140                 


Gly Asn Ala Ser His Leu Phe Gln Leu Asp Arg Val Ser Asn Val Leu 
145                 150                 155                 160 


Gln Leu Ala Gln Leu Leu Asp Arg Glu Glu Ile Pro Thr Pro Glu Ile 
                165                 170                 175     


Arg Ile Val Ala Thr Asn Asn Glu Asn Ser Pro Pro Asp Thr Val Leu 
            180                 185                 190         


Glu Ser Ser Pro Ser Leu Leu Val Val Arg Ile Lys Val Asn Asp Val 
        195                 200                 205             


Asn Asp Asn Pro Pro Val Phe Gln Gln Arg Leu Tyr Ala Ala Gly Ile 
    210                 215                 220                 


Thr Thr Asn Asp Arg Val Pro Lys Ala Leu Phe Arg Val Tyr Ala Glu 
225                 230                 235                 240 


Asp Pro Asp Glu Asp Glu Ile Ile Arg Tyr Glu Leu Val Asn Gly Thr 
                245                 250                 255     


Ala Val Gly Glu Asn Leu Gln Thr Asp Gly Leu Pro Phe Arg Leu His 
            260                 265                 270         


Pro Asp Ser Gly Glu Leu Thr Leu Thr Ser Lys Val Gln Pro Asn Gln 
        275                 280                 285             


Asn Gly Tyr Tyr Gln Leu Thr Leu Ile Ala Phe Asp Arg Asp Asp Thr 
    290                 295                 300                 


His Asn Asp Thr Val Pro Ala Lys Val Tyr Ile Val Ser Glu Ser Asn 
305                 310                 315                 320 


Arg Val Thr Phe Val Phe 
                325     


<210>  7
<211>  5646
<212>  DNA
<213>  Anopheles gambiae

<400>  7
atggaacaga atcgctcaac cgataagcta cagatggaaa tactcaagcg aaccgtctgc       60

cggctcaaac cgtcggccca ccggtgccta ttggccggat ctcattcctt cacgcagcta      120

gtgctctgcc tcatcctaag cgccaccctg gtcagctgca accgtgcgcc agtgtttctg      180

atcgacgatc atgcggaaat agttatacga ttgagggagt tccccgagac gcccgtgggg      240

acgctgatct accggctgcg tgggtacgat gcggatggcg atccgcttac ctttggcgtg      300

cagaagagtg ccgacagcca catcataaga ctgaaacaga acacttccag cgaagcgttc      360

gtctacctca accacgagct cgaccgggag gcacgcgaag agtacacgct catcctcacg      420

ctcaccgatg ggcggctcgg tgagggtaac ttcgtgacgc agagcttcct gctgctggtg      480

gaagatatca acgataatga gccgatcttt aaaccgttcg cctctgtgct ggaggtagcg      540

gaggacagtc cgccggggat tttgaccacg ctggaggccg tcgataagga cgagggtgcg      600

tacgggcagg tcgtgtacta catccaaggg ttaagcgagg agaacaacgt gttttcgatc      660

tccacttcca atgggaaggg tgtggtacgg ctggcccgag cgctggacta cgagcggcaa      720

catttctatc acatcaatgt gctggcagtg gaccgggcga tacaggggag gatcaacact      780

ggaactgcag cactgctcgt gagagtgaag gacgtggagg accagccgcc cgagtttctg      840

gtaacgcaac cggtggtacg aatatccgag gatgctccaa ttggaacgga agtgattgcg      900

aggatgatct attctctttc aacagtcaaa gctgtggatg gtgatcgagg aattaataat      960

cgaattattt acgggatttc aaacaacggc agtgaactgt ttgagattga tcggttgaag     1020

ggttcactgc gaacgaaaca gaagctcgac agggaggact ccacgaatcc catcaacggt     1080

gctttcatac tggaagtggt tgcgattgaa gagagcaagc tacagcctgc gccttcctca     1140

acaatggaga tcaccgtgat cgtgacggat gtgaacgacg aaataccacg cttccgaagc     1200

gacggctatg agtgtgagat tggcgagaac gcacaggaga acacgctggc ccggttcatc     1260

gacggcagca tcaacgaggt gtttgactac gatcagggta aaaatggcac gtttcgactg     1320

tcgctccatc cgccgagtga catcttcgag gtgattccaa agcgagcgat caacgaggcc     1380

acattcgggt tgcgtgtgaa ggatccgtcc atgctcgatt acgagcgggt tcgggagctg     1440

tccctcacag tggtggcgag tgaggttgag tccgctggtc gtaccagtac cgcccagata     1500

cgggtggtcg tgctggatca gaacgataac tttcccgagt tttcacagcc cgtctacgac     1560

attgatgtac cggagaatgt gatagccggt acggtgttgt tgcagctaca agcaacggat     1620

agtgattcgg gcctgttcgg cacggagggt gtacggtacg cgaacctgac tggtagtatc     1680

tcgagctttc tccatctgga tccacacgct ggcacggtga cacttatggc atcggagagt     1740

cccgtgtttg atcgtgaaat catccaaaag cactacctct cggtggaggc ccgtgataat     1800

ggcggtcggg gcaatcggaa cacggtgcca ctgatactga acgtgctcga tgtgaacgac     1860

aatgccccag tgtttgtgca gaagcggtac gaggtgagac tgaaggagaa tgcgtttgag     1920

tttgagtccc cgatcgtggt ggaagcgcgt gacagcgacc tagaaggctc gccgaacagt     1980

gcggtagagt atcggttgat tggtgctcac cattccgact acttccatgt ggataggcgc     2040

acgggaagac tctcagtgcg tgaagcagtt gactttgaac ggttggaaag tagtggcggt     2100

agtggtgaca cgcgaaccat tgcacttacc attgaggcgg cggatggtgg ggagccaccg     2160

ctgactgccc aggtcgaggt gacggtgtac gtgcaggacg tgaacgatta tgcgcccgtt     2220

tttctggagt cacagtacgc gatcgtcata ccggaggaca cgccgagcgg gttgcccgtg     2280

ctgcgcgtga ccgcgatgga tggagatggg tcttttccca acaaccacgt cacgtaccgg     2340

atacagcagg gtggtgatgg taggttcgta ataggagcta gtacaggcga gatatcgatc     2400

acgcacggtg catcgctgga tccgaatctg ctcgcgcccg atgcgctggg ctcggggtca     2460

acgtacgtgc tggaggtgtt cgctaccgat ggtggcaatg gagatcagca gctgcaagga     2520

tcctgtctgg tgaacaatac gcccgtcggc accgaagtgt accggctgat ggccaccgat     2580

ccggacgagg gtgcaatgct gcggtactac atcgatcgaa gcctatcgga gggcaagact     2640

gaggagggtg cactggtgaa gctggacgat tatgactttg cggcggcctt catactgaac     2700

gaaacgaatg gactgctcaa gatagcaaag ctgctggatc gcgaaaagat tgccgaaatc     2760

aagctggcct gtgtggtgga ggacgtagcg gccgagcggg gtgaccagat ggcaaacacc     2820

ttcctcaaga tcaccgtgct cgacgagaac gacaacaatc ccaagttccg caaaccgttc     2880

tacaaacact ccattgcgga aaacagtcag tacggtgtgg cggtatgtac ggtggtggcc     2940

gaagatgccg atcagaacaa aacggtcaag tacagcttgg aaggggagaa gggtgtgctg     3000

gagttgctgc acgttgatga cgagacgggg gagattgtgg tgcgcaatcg gatcgatcat     3060

gaggagtaca gttggttgaa cttctcggta cgggcggctg atacgggcac gccgccgaga     3120

gcgtcctttg tggaggtgtt cgtgcaggtg ctggatgaga acgacaacaa tccttacttt     3180

gtggacagcg tgaacgatta ctacgtgtcg gagaatgcaa gcgtgggagc ggagatagcg     3240

atcatactgg cgaaggatct agattcgggg gatttcggac gcatcacgta catactggat     3300

cgtgttagct cgaaggagaa gtttagcatt gatccggaga aaggaatact acgagtagcg     3360

ggagcattgg atcgggaaga gacagctgag tatatgttgg cagtagaggc atgggataac     3420

tatccttacg gctatctcaa cggtgaaagc cgcaacgctt ttaaacacat actgatacac     3480

gtgctggacg acaatgacaa cgttcccgtg atccagaaac cttccgggtg tagtatgatc     3540

accgagtacc acaacatcaa cgatccgatc gtgaagctgc gggcaaccga tgcggacgac     3600

ccaaccaatg gaaacggtca actgagcttc gacattgtgg acccctcggg gatattctac     3660

atccagcagg tgtcggccca gtacgcagaa atatattccc gcgggccgct aaagaatctg     3720

cacggcaact acacgctgga gctgatagtg agcgatcttg gcggcgtacc gaacacggcc     3780

cgagagtcgg tggacatctg tgtgacggat ttcaacgacc atgcgccagt gtttgttgtc     3840

cccagtggaa atacaactgt gaaggtgttt gagaacacaa cgctcggtaa gccgttcttt     3900

caagtgcacg cgtacgatga agatgtcggc gaaaatgcga ttgtgcgcta ccgactgaag     3960

atggacacga tgggcaactt tcgcaagttt tccctcgaca aggagacggg cgagcttagc     4020

ctcgctgcgc ctctcgatcg cgagcagcag atgatgtacg atctgcgcat cgaagcgtac     4080

gatcagggta taccgacgcc gctcagcagt acggtcgatc tgatcgtgta cgtgcgggac     4140

gtcaacgaca atctacctca gtttttgctc aaggaaatca gtcttaactt tacggagcac     4200

atgacaccgg gcacggaaag aatacgcctg cccgacacgg tcgaccagga ctatctggac     4260

ccgctggacg gtccggcggc gagtgtggtt tgctactaca tcgtgcacgg caacgaggat     4320

ggacactttg gactggatcc agtgtcacac gatctaacgg tggagaaaga gctcgatcgg     4380

gagaaaaaat ctctgtacaa gctgcacatt aaggcgacgg aggagtgcac gaacgcgaat     4440

ctatcgttgg acacgaccag tcactcgggc aatctcctaa aggctactgt gtacataaac     4500

gacatcaacg acaactcgcc agtgtttgag tcgaaaatat tcaccggcgg tatctcaacg     4560

tcgtcgctgt tcggtgccac aattcttcag ctgcaggcca cggacgaaga cgatggattg     4620

aacggattgg ttcggtacta tcggcacggc gaggtgcgga aaacgcttgc cgaggggttg     4680

gacgatttgc gcagcgatcc gttcctggtc gaggcggaca cgggccaagt gttgctgaac     4740

tttttccccc agaagtcgat gcgcggctac tttgactttt ccgtgctggc gaacgattcg     4800

tacggctgcc atgatcgggc gcacgtgttc atctatctga tacgggagga tcagcgggta     4860

aagtttatac tgcgccaacg gccgtccgag attcgtcaca acattcaaag ttttcgcgag     4920

atcttgagca atgtgagtgg atgcatcgtg aacattgacg atatacgggt gcacgagaat     4980

ccggacggtt cggttgatag gaccaagagc gacatgttta tgcatctggt cgatcagaag     5040

aacaactccg tgctggaggt acatcaggtg ctgcagttgc tggatacgca cgtggaaaag     5100

cttgatcgac tgtttaagga attcaacgtc ttggacactc aagcgtcgga gctggtccaa     5160

acggcagaga tggacgagct gtccgtcaac ataatatggc tgtttgtgac caacattttg     5220

ctcggcgcgc tgctgatcgt tgtaatagga ctgtcgatct cacagcgttt atcctaccgc     5280

agacagctac gggcagcgaa gatagctgcc tttggctcca cgggtcctag tcgcatgtat     5340

caggaagtgc tcggcgccgt accgaacacg aacaagcaca gcatgaaggg cagcaacccg     5400

atctggatcg gcagcggcac accggagggc gaatgggcga aggacgagtt cgacaagtgc     5460

aaggatgcga tcgacgcaca gtacgaacga tcgctcagct cgggcttctt catcgacaac     5520

tgtctgcagt acgaggcacg gaagggtttc gccggggccg aagcgaacaa cgccgccaac     5580

tatcagctca agcgggacag cgagacgacg ctgtgcgccc ggaacttgga aacgaccgaa     5640

ctgtaa                                                                5646


<210>  8
<211>  1881
<212>  PRT
<213>  Anopheles gambiae

<400>  8

Met Glu Gln Asn Arg Ser Thr Asp Lys Leu Gln Met Glu Ile Leu Lys 
1               5                   10                  15      


Arg Thr Val Cys Arg Leu Lys Pro Ser Ala His Arg Cys Leu Leu Ala 
            20                  25                  30          


Gly Ser His Ser Phe Thr Gln Leu Val Leu Cys Leu Ile Leu Ser Ala 
        35                  40                  45              


Thr Leu Val Ser Cys Asn Arg Ala Pro Val Phe Leu Ile Asp Asp His 
    50                  55                  60                  


Ala Glu Ile Val Ile Arg Leu Arg Glu Phe Pro Glu Thr Pro Val Gly 
65                  70                  75                  80  


Thr Leu Ile Tyr Arg Leu Arg Gly Tyr Asp Ala Asp Gly Asp Pro Leu 
                85                  90                  95      


Thr Phe Gly Val Gln Lys Ser Ala Asp Ser His Ile Ile Arg Leu Lys 
            100                 105                 110         


Gln Asn Thr Ser Ser Glu Ala Phe Val Tyr Leu Asn His Glu Leu Asp 
        115                 120                 125             


Arg Glu Ala Arg Glu Glu Tyr Thr Leu Ile Leu Thr Leu Thr Asp Gly 
    130                 135                 140                 


Arg Leu Gly Glu Gly Asn Phe Val Thr Gln Ser Phe Leu Leu Leu Val 
145                 150                 155                 160 


Glu Asp Ile Asn Asp Asn Glu Pro Ile Phe Lys Pro Phe Ala Ser Val 
                165                 170                 175     


Leu Glu Val Ala Glu Asp Ser Pro Pro Gly Ile Leu Thr Thr Leu Glu 
            180                 185                 190         


Ala Val Asp Lys Asp Glu Gly Ala Tyr Gly Gln Val Val Tyr Tyr Ile 
        195                 200                 205             


Gln Gly Leu Ser Glu Glu Asn Asn Val Phe Ser Ile Ser Thr Ser Asn 
    210                 215                 220                 


Gly Lys Gly Val Val Arg Leu Ala Arg Ala Leu Asp Tyr Glu Arg Gln 
225                 230                 235                 240 


His Phe Tyr His Ile Asn Val Leu Ala Val Asp Arg Ala Ile Gln Gly 
                245                 250                 255     


Arg Ile Asn Thr Gly Thr Ala Ala Leu Leu Val Arg Val Lys Asp Val 
            260                 265                 270         


Glu Asp Gln Pro Pro Glu Phe Leu Val Thr Gln Pro Val Val Arg Ile 
        275                 280                 285             


Ser Glu Asp Ala Pro Ile Gly Thr Glu Val Ile Ala Arg Met Ile Tyr 
    290                 295                 300                 


Ser Leu Ser Thr Val Lys Ala Val Asp Gly Asp Arg Gly Ile Asn Asn 
305                 310                 315                 320 


Arg Ile Ile Tyr Gly Ile Ser Asn Asn Gly Ser Glu Leu Phe Glu Ile 
                325                 330                 335     


Asp Arg Leu Lys Gly Ser Leu Arg Thr Lys Gln Lys Leu Asp Arg Glu 
            340                 345                 350         


Asp Ser Thr Asn Pro Ile Asn Gly Ala Phe Ile Leu Glu Val Val Ala 
        355                 360                 365             


Ile Glu Glu Ser Lys Leu Gln Pro Ala Pro Ser Ser Thr Met Glu Ile 
    370                 375                 380                 


Thr Val Ile Val Thr Asp Val Asn Asp Glu Ile Pro Arg Phe Arg Ser 
385                 390                 395                 400 


Asp Gly Tyr Glu Cys Glu Ile Gly Glu Asn Ala Gln Glu Asn Thr Leu 
                405                 410                 415     


Ala Arg Phe Ile Asp Gly Ser Ile Asn Glu Val Phe Asp Tyr Asp Gln 
            420                 425                 430         


Gly Lys Asn Gly Thr Phe Arg Leu Ser Leu His Pro Pro Ser Asp Ile 
        435                 440                 445             


Phe Glu Val Ile Pro Lys Arg Ala Ile Asn Glu Ala Thr Phe Gly Leu 
    450                 455                 460                 


Arg Val Lys Asp Pro Ser Met Leu Asp Tyr Glu Arg Val Arg Glu Leu 
465                 470                 475                 480 


Ser Leu Thr Val Val Ala Ser Glu Val Glu Ser Ala Gly Arg Thr Ser 
                485                 490                 495     


Thr Ala Gln Ile Arg Val Val Val Leu Asp Gln Asn Asp Asn Phe Pro 
            500                 505                 510         


Glu Phe Ser Gln Pro Val Tyr Asp Ile Asp Val Pro Glu Asn Val Ile 
        515                 520                 525             


Ala Gly Thr Val Leu Leu Gln Leu Gln Ala Thr Asp Ser Asp Ser Gly 
    530                 535                 540                 


Leu Phe Gly Thr Glu Gly Val Arg Tyr Ala Asn Leu Thr Gly Ser Ile 
545                 550                 555                 560 


Ser Ser Phe Leu His Leu Asp Pro His Ala Gly Thr Val Thr Leu Met 
                565                 570                 575     


Ala Ser Glu Ser Pro Val Phe Asp Arg Glu Ile Ile Gln Lys His Tyr 
            580                 585                 590         


Leu Ser Val Glu Ala Arg Asp Asn Gly Gly Arg Gly Asn Arg Asn Thr 
        595                 600                 605             


Val Pro Leu Ile Leu Asn Val Leu Asp Val Asn Asp Asn Ala Pro Val 
    610                 615                 620                 


Phe Val Gln Lys Arg Tyr Glu Val Arg Leu Lys Glu Asn Ala Phe Glu 
625                 630                 635                 640 


Phe Glu Ser Pro Ile Val Val Glu Ala Arg Asp Ser Asp Leu Glu Gly 
                645                 650                 655     


Ser Pro Asn Ser Ala Val Glu Tyr Arg Leu Ile Gly Ala His His Ser 
            660                 665                 670         


Asp Tyr Phe His Val Asp Arg Arg Thr Gly Arg Leu Ser Val Arg Glu 
        675                 680                 685             


Ala Val Asp Phe Glu Arg Leu Glu Ser Ser Gly Gly Ser Gly Asp Thr 
    690                 695                 700                 


Arg Thr Ile Ala Leu Thr Ile Glu Ala Ala Asp Gly Gly Glu Pro Pro 
705                 710                 715                 720 


Leu Thr Ala Gln Val Glu Val Thr Val Tyr Val Gln Asp Val Asn Asp 
                725                 730                 735     


Tyr Ala Pro Val Phe Leu Glu Ser Gln Tyr Ala Ile Val Ile Pro Glu 
            740                 745                 750         


Asp Thr Pro Ser Gly Leu Pro Val Leu Arg Val Thr Ala Met Asp Gly 
        755                 760                 765             


Asp Gly Ser Phe Pro Asn Asn His Val Thr Tyr Arg Ile Gln Gln Gly 
    770                 775                 780                 


Gly Asp Gly Arg Phe Val Ile Gly Ala Ser Thr Gly Glu Ile Ser Ile 
785                 790                 795                 800 


Thr His Gly Ala Ser Leu Asp Pro Asn Leu Leu Ala Pro Asp Ala Leu 
                805                 810                 815     


Gly Ser Gly Ser Thr Tyr Val Leu Glu Val Phe Ala Thr Asp Gly Gly 
            820                 825                 830         


Asn Gly Asp Gln Gln Leu Gln Gly Ser Cys Leu Val Asn Asn Thr Pro 
        835                 840                 845             


Val Gly Thr Glu Val Tyr Arg Leu Met Ala Thr Asp Pro Asp Glu Gly 
    850                 855                 860                 


Ala Met Leu Arg Tyr Tyr Ile Asp Arg Ser Leu Ser Glu Gly Lys Thr 
865                 870                 875                 880 


Glu Glu Gly Ala Leu Val Lys Leu Asp Asp Tyr Asp Phe Ala Ala Ala 
                885                 890                 895     


Phe Ile Leu Asn Glu Thr Asn Gly Leu Leu Lys Ile Ala Lys Leu Leu 
            900                 905                 910         


Asp Arg Glu Lys Ile Ala Glu Ile Lys Leu Ala Cys Val Val Glu Asp 
        915                 920                 925             


Val Ala Ala Glu Arg Gly Asp Gln Met Ala Asn Thr Phe Leu Lys Ile 
    930                 935                 940                 


Thr Val Leu Asp Glu Asn Asp Asn Asn Pro Lys Phe Arg Lys Pro Phe 
945                 950                 955                 960 


Tyr Lys His Ser Ile Ala Glu Asn Ser Gln Tyr Gly Val Ala Val Cys 
                965                 970                 975     


Thr Val Val Ala Glu Asp Ala Asp Gln Asn Lys Thr Val Lys Tyr Ser 
            980                 985                 990         


Leu Glu Gly Glu Lys Gly Val Leu  Glu Leu Leu His Val  Asp Asp Glu 
        995                 1000                 1005             


Thr Gly  Glu Ile Val Val Arg  Asn Arg Ile Asp His  Glu Glu Tyr 
    1010                 1015                 1020             


Ser Trp  Leu Asn Phe Ser Val  Arg Ala Ala Asp Thr  Gly Thr Pro 
    1025                 1030                 1035             


Pro Arg  Ala Ser Phe Val Glu  Val Phe Val Gln Val  Leu Asp Glu 
    1040                 1045                 1050             


Asn Asp  Asn Asn Pro Tyr Phe  Val Asp Ser Val Asn  Asp Tyr Tyr 
    1055                 1060                 1065             


Val Ser  Glu Asn Ala Ser Val  Gly Ala Glu Ile Ala  Ile Ile Leu 
    1070                 1075                 1080             


Ala Lys  Asp Leu Asp Ser Gly  Asp Phe Gly Arg Ile  Thr Tyr Ile 
    1085                 1090                 1095             


Leu Asp  Arg Val Ser Ser Lys  Glu Lys Phe Ser Ile  Asp Pro Glu 
    1100                 1105                 1110             


Lys Gly  Ile Leu Arg Val Ala  Gly Ala Leu Asp Arg  Glu Glu Thr 
    1115                 1120                 1125             


Ala Glu  Tyr Met Leu Ala Val  Glu Ala Trp Asp Asn  Tyr Pro Tyr 
    1130                 1135                 1140             


Gly Tyr  Leu Asn Gly Glu Ser  Arg Asn Ala Phe Lys  His Ile Leu 
    1145                 1150                 1155             


Ile His  Val Leu Asp Asp Asn  Asp Asn Val Pro Val  Ile Gln Lys 
    1160                 1165                 1170             


Pro Ser  Gly Cys Ser Met Ile  Thr Glu Tyr His Asn  Ile Asn Asp 
    1175                 1180                 1185             


Pro Ile  Val Lys Leu Arg Ala  Thr Asp Ala Asp Asp  Pro Thr Asn 
    1190                 1195                 1200             


Gly Asn  Gly Gln Leu Ser Phe  Asp Ile Val Asp Pro  Ser Gly Ile 
    1205                 1210                 1215             


Phe Tyr  Ile Gln Gln Val Ser  Ala Gln Tyr Ala Glu  Ile Tyr Ser 
    1220                 1225                 1230             


Arg Gly  Pro Leu Lys Asn Leu  His Gly Asn Tyr Thr  Leu Glu Leu 
    1235                 1240                 1245             


Ile Val  Ser Asp Leu Gly Gly  Val Pro Asn Thr Ala  Arg Glu Ser 
    1250                 1255                 1260             


Val Asp  Ile Cys Val Thr Asp  Phe Asn Asp His Ala  Pro Val Phe 
    1265                 1270                 1275             


Val Val  Pro Ser Gly Asn Thr  Thr Val Lys Val Phe  Glu Asn Thr 
    1280                 1285                 1290             


Thr Leu  Gly Lys Pro Phe Phe  Gln Val His Ala Tyr  Asp Glu Asp 
    1295                 1300                 1305             


Val Gly  Glu Asn Ala Ile Val  Arg Tyr Arg Leu Lys  Met Asp Thr 
    1310                 1315                 1320             


Met Gly  Asn Phe Arg Lys Phe  Ser Leu Asp Lys Glu  Thr Gly Glu 
    1325                 1330                 1335             


Leu Ser  Leu Ala Ala Pro Leu  Asp Arg Glu Gln Gln  Met Met Tyr 
    1340                 1345                 1350             


Asp Leu  Arg Ile Glu Ala Tyr  Asp Gln Gly Ile Pro  Thr Pro Leu 
    1355                 1360                 1365             


Ser Ser  Thr Val Asp Leu Ile  Val Tyr Val Arg Asp  Val Asn Asp 
    1370                 1375                 1380             


Asn Leu  Pro Gln Phe Leu Leu  Lys Glu Ile Ser Leu  Asn Phe Thr 
    1385                 1390                 1395             


Glu His  Met Thr Pro Gly Thr  Glu Arg Ile Arg Leu  Pro Asp Thr 
    1400                 1405                 1410             


Val Asp  Gln Asp Tyr Leu Asp  Pro Leu Asp Gly Pro  Ala Ala Ser 
    1415                 1420                 1425             


Val Val  Cys Tyr Tyr Ile Val  His Gly Asn Glu Asp  Gly His Phe 
    1430                 1435                 1440             


Gly Leu  Asp Pro Val Ser His  Asp Leu Thr Val Glu  Lys Glu Leu 
    1445                 1450                 1455             


Asp Arg  Glu Lys Lys Ser Leu  Tyr Lys Leu His Ile  Lys Ala Thr 
    1460                 1465                 1470             


Glu Glu  Cys Thr Asn Ala Asn  Leu Ser Leu Asp Thr  Thr Ser His 
    1475                 1480                 1485             


Ser Gly  Asn Leu Leu Lys Ala  Thr Val Tyr Ile Asn  Asp Ile Asn 
    1490                 1495                 1500             


Asp Asn  Ser Pro Val Phe Glu  Ser Lys Ile Phe Thr  Gly Gly Ile 
    1505                 1510                 1515             


Ser Thr  Ser Ser Leu Phe Gly  Ala Thr Ile Leu Gln  Leu Gln Ala 
    1520                 1525                 1530             


Thr Asp  Glu Asp Asp Gly Leu  Asn Gly Leu Val Arg  Tyr Tyr Arg 
    1535                 1540                 1545             


His Gly  Glu Val Arg Lys Thr  Leu Ala Glu Gly Leu  Asp Asp Leu 
    1550                 1555                 1560             


Arg Ser  Asp Pro Phe Leu Val  Glu Ala Asp Thr Gly  Gln Val Leu 
    1565                 1570                 1575             


Leu Asn  Phe Phe Pro Gln Lys  Ser Met Arg Gly Tyr  Phe Asp Phe 
    1580                 1585                 1590             


Ser Val  Leu Ala Asn Asp Ser  Tyr Gly Cys His Asp  Arg Ala His 
    1595                 1600                 1605             


Val Phe  Ile Tyr Leu Ile Arg  Glu Asp Gln Arg Val  Lys Phe Ile 
    1610                 1615                 1620             


Leu Arg  Gln Arg Pro Ser Glu  Ile Arg His Asn Ile  Gln Ser Phe 
    1625                 1630                 1635             


Arg Glu  Ile Leu Ser Asn Val  Ser Gly Cys Ile Val  Asn Ile Asp 
    1640                 1645                 1650             


Asp Ile  Arg Val His Glu Asn  Pro Asp Gly Ser Val  Asp Arg Thr 
    1655                 1660                 1665             


Lys Ser  Asp Met Phe Met His  Leu Val Asp Gln Lys  Asn Asn Ser 
    1670                 1675                 1680             


Val Leu  Glu Val His Gln Val  Leu Gln Leu Leu Asp  Thr His Val 
    1685                 1690                 1695             


Glu Lys  Leu Asp Arg Leu Phe  Lys Glu Phe Asn Val  Leu Asp Thr 
    1700                 1705                 1710             


Gln Ala  Ser Glu Leu Val Gln  Thr Ala Glu Met Asp  Glu Leu Ser 
    1715                 1720                 1725             


Val Asn  Ile Ile Trp Leu Phe  Val Thr Asn Ile Leu  Leu Gly Ala 
    1730                 1735                 1740             


Leu Leu  Ile Val Val Ile Gly  Leu Ser Ile Ser Gln  Arg Leu Ser 
    1745                 1750                 1755             


Tyr Arg  Arg Gln Leu Arg Ala  Ala Lys Ile Ala Ala  Phe Gly Ser 
    1760                 1765                 1770             


Thr Gly  Pro Ser Arg Met Tyr  Gln Glu Val Leu Gly  Ala Val Pro 
    1775                 1780                 1785             


Asn Thr  Asn Lys His Ser Met  Lys Gly Ser Asn Pro  Ile Trp Ile 
    1790                 1795                 1800             


Gly Ser  Gly Thr Pro Glu Gly  Glu Trp Ala Lys Asp  Glu Phe Asp 
    1805                 1810                 1815             


Lys Cys  Lys Asp Ala Ile Asp  Ala Gln Tyr Glu Arg  Ser Leu Ser 
    1820                 1825                 1830             


Ser Gly  Phe Phe Ile Asp Asn  Cys Leu Gln Tyr Glu  Ala Arg Lys 
    1835                 1840                 1845             


Gly Phe  Ala Gly Ala Glu Ala  Asn Asn Ala Ala Asn  Tyr Gln Leu 
    1850                 1855                 1860             


Lys Arg  Asp Ser Glu Thr Thr  Leu Cys Ala Arg Asn  Leu Glu Thr 
    1865                 1870                 1875             


Thr Glu  Leu 
    1880     


<210>  9
<211>  639
<212>  DNA
<213>  Anopheles gambiae

<400>  9
ggtatctcaa cgtcgtcgct gttcggtgcc acaattcttc agctgcaggc cacggacgaa       60

gacgatggat tgaacggatt ggttcggtac tatcggcacg gcgaggtgcg gaaaacgctt      120

gccgaggggt tggacgattt gcgcagcgat ccgttcctgg tcgaggcgga cacgggccaa      180

gtgttgctga actttttccc ccagaagtcg atgcgcggct actttgactt ttccgtgctg      240

gcgaacgatt cgtacggctg ccatgatcgg gcgcacgtgt tcatctatct gatacgggag      300

gatcagcggg taaagtttat actgcgccaa cggccgtccg agattcgtca caacattcaa      360

agttttcgcg agatcttgag caatgtgagt ggatgcatcg tgaacattga cgatatacgg      420

gtgcacgaga atccggacgg ttcggttgat aggaccaaga gcgacatgtt tatgcatctg      480

gtcgatcaga agaacaactc cgtgctggag gtacatcagg tgctgcagtt gctggatacg      540

cacgtggaaa agcttgatcg actgtttaag gaattcaacg tcttggacac tcaagcgtcg      600

gagctggtcc aaacggcaga gatggacgag ctgtccgtc                             639


<210>  10
<211>  213
<212>  PRT
<213>  Anopheles gambiae

<400>  10

Gly Ile Ser Thr Ser Ser Leu Phe Gly Ala Thr Ile Leu Gln Leu Gln 
1               5                   10                  15      


Ala Thr Asp Glu Asp Asp Gly Leu Asn Gly Leu Val Arg Tyr Tyr Arg 
            20                  25                  30          


His Gly Glu Val Arg Lys Thr Leu Ala Glu Gly Leu Asp Asp Leu Arg 
        35                  40                  45              


Ser Asp Pro Phe Leu Val Glu Ala Asp Thr Gly Gln Val Leu Leu Asn 
    50                  55                  60                  


Phe Phe Pro Gln Lys Ser Met Arg Gly Tyr Phe Asp Phe Ser Val Leu 
65                  70                  75                  80  


Ala Asn Asp Ser Tyr Gly Cys His Asp Arg Ala His Val Phe Ile Tyr 
                85                  90                  95      


Leu Ile Arg Glu Asp Gln Arg Val Lys Phe Ile Leu Arg Gln Arg Pro 
            100                 105                 110         


Ser Glu Ile Arg His Asn Ile Gln Ser Phe Arg Glu Ile Leu Ser Asn 
        115                 120                 125             


Val Ser Gly Cys Ile Val Asn Ile Asp Asp Ile Arg Val His Glu Asn 
    130                 135                 140                 


Pro Asp Gly Ser Val Asp Arg Thr Lys Ser Asp Met Phe Met His Leu 
145                 150                 155                 160 


Val Asp Gln Lys Asn Asn Ser Val Leu Glu Val His Gln Val Leu Gln 
                165                 170                 175     


Leu Leu Asp Thr His Val Glu Lys Leu Asp Arg Leu Phe Lys Glu Phe 
            180                 185                 190         


Asn Val Leu Asp Thr Gln Ala Ser Glu Leu Val Gln Thr Ala Glu Met 
        195                 200                 205             


Asp Glu Leu Ser Val 
    210             


<210>  11
<211>  5154
<212>  DNA
<213>  Manduca sexta

<400>  11
atggcagttg acgtccgaat cgctgccttc ctgctggtgt ttatagcgcc tgcagtttta       60

gctcaagaga gatgcgggta tatgaccgcc atcccaaggc taccacgacc ggataatttg      120

ccagtactaa actttgaagg ccagacatgg agtcagaggc ccctgctccc cgccccggag      180

cgggatgacc tgtgcatgga cgcctaccac gtgataacag ccaacctcgg cacgcaggtc      240

atctacatgg atgaagagat agaagacgaa atcaccatcg ccatacttaa ttataacgga      300

ccatcaactc cgttcattga actgccattt ttatccggtt cgtacaatct gctgatgccg      360

gtcatcagga gagttgacaa cggggagtgg catctcatca tcacgcaaag acaggattac      420

gagttgcccg gcatgcagca gtacatgttc aatgtgcgcg tggacggcca gtcgctggtg      480

gcaggcgtgt ctctcgctat cgtcaacata gatgacaacg cgcccatcat acaaaacttc      540

gagccttgcc gggttcctga actgggcgag ccagggttga cagaatgcac ataccaagta      600

tcggacgcgg acggacggat cagtacagag ttcatgacgt tcaggatcga cagcgttcgt      660

ggcgacgagg agaccttcta catcgaacgg acgaatatcc ccaaccaatg gatgtggcta      720

aatatgacct taggcgttaa tacctcgctc aacttcgtca ccagtccgct gcatatattc      780

agcgtgacag ccctggactc gctcccgaac acccacacgg tgactatgat ggtgcaagtg      840

gcgaatgtga acagccgtcc gccgcgctgg ctggagatct tcgctgtcca acagtttgaa      900

gagaaatctt accaaaactt cacagtgagg gcgatcgacg gagacactga gatcaatatg      960

cctatcaact acaggctgat cacaaatgag gaagacacat tcttcagcat cgaggccctg     1020

cctggtggaa aaagcggggc tatattccac gtgtcaccaa ttgaccgcga cacactgcaa     1080

cgagaggtgt ttccacttac gatcgtcgct tacaaatacg atgaggaagc tttctccaca     1140

tcaacaaacg tggtcatcat tgtgacagac atcaacgacc aaagacctga acctatacac     1200

aaggaatatc gactggcgat catggaggag acgcccatga ccctcaactt cgataaagaa     1260

tttggatttc atgataagga tttaggtcaa aacgctcagt acacggtgcg tctagagagc     1320

gtggaccctc caggcgctgc tgaggcattc tacatagcgc ctgaagtcgg ctaccagcga     1380

cagaccttca tcatgggcac cctcaatcac tccatgctgg attacgaagt gccagagttt     1440

cagagtatta cgattcgggt ggtagcgacc gacaacaacg acacgaggca cgtgggcgtc     1500

gctttggttc acattgacct catcaattgg aacgatgagc agccgatctt cgaacacgcc     1560

gtgcagaccg tgaccttcga cgagactgaa ggcgaggggt tcttcgtcgc caaggcggtt     1620

gcacacgaca gagacatcgg ggatgtcgtc gagcatactt tactgggtaa cgctgttaac     1680

ttcctgacca tcgacaaact caccggcgac atccgcgtct cagctaacga ctccttcaac     1740

taccatcgag aaagtgaatt atttgtgcag gtgcgagcta cagacacgct gggcgaaccc     1800

ttccacacga cgacgtcaca gctggtcata cgactaaatg acatcaacaa cacgccaccc     1860

accttacggc tgcctcgagg cagtccccaa gtggaggaga acgtgcctga tggccacgtc     1920

atcacccagg agttacgcgc caccgacccc gacaccacgg ccgatctgcg cttcgagata     1980

aactgggaca cctctttcgc caccaagcaa ggccgccagg ctaaccccga cgagtttagg     2040

aattgcgtgg aaatcgagac catcttcccc gagattaaca accggggact ggctatcggc     2100

cgcgttgtag cgcgcgagat cagacacaac gtgaccatag actacgagga gtttgaggtc     2160

ctctccctca cagtgagggt gcgggacctg aacaccgtct acggagacga ctacgacgaa     2220

tcgatgctca caataactat aatcgacatg aacgacaacg cgccggtgtg ggtggagggg     2280

actctggagc agaacttccg cgtgcgcgag atgtccgcgg gcgggctcgt ggtgggctcc     2340

gtgcgcgcgg acgacatcga cggaccgctc tacaaccaag tgcgatacac cattttccct     2400

cgtgaagaca cagataagga cctgataatg atcgacttcc tcacgggtca aatttccgtg     2460

aacacaagcg gcgccatcga cgcggacacc cctcctcgct tccacctcta ctacacagtg     2520

gtcgctagtg accgatgctc gacagaagat cctgcagatt gcccccctga tccgacttat     2580

tgggaaaccg aaggaaatat cacaatccac atcaccgaca cgaacaacaa ggtcccgcag     2640

gcggaaacga ctaagttcga taccgtcgtg tatatttacg agaacgcaac ccacttggac     2700

gaggtggtca ctctgatagc cagtgatctt gacagagacg aaatatacca cacggtgagc     2760

tacgtcatca attacgcagt gaaccctcga ctgatgaact tcttctccgt gaaccgggag     2820

accggcctgg tgtacgtaga ctatgagacc caggggagtg gcgaggtgct ggaccgtgat     2880

ggtgatgaac caacgcaccg tatcttcttc aacctcatcg acaacttcat gggggaagga     2940

gaaggtaaca gaaatcagaa cgacacagaa gttctcgtta tcttgttgga tgtgaatgac     3000

aatgctcctg aattgccacc gccgagcgaa ctctcttgga ctatatctga gaaccttaag     3060

cagggcgtcc gtcttgaacc gcatatcttc gccccggacc gcgacgagcc cgacacggac     3120

aactccaggg tcggttacga gatcctgaac ctcagcacgg agcgggacat cgaagtgccg     3180

gagctgtttg taatgataca gatcgcgaac gtcacgggag agctggagac cgccatggac     3240

ctcaagggat attgggggac gtacgctata catatacggg cattcgacca cggcattccg     3300

caaatgtcca tgaacgagac atatgagctg attatccatc cgttcaacta ctacgcgcct     3360

gagttcgtct tcccgaccaa cgatgccgtc atacgacttg cgagggaacg agctgtaatc     3420

aatggagttc tagcgacagt gaacggagag ttcttggagc ggatatcggc gactgacccg     3480

gacggactcc acgcgggcgt cgtcaccttc caagtggtag gcgatgagga atcacaacgg     3540

tactttcaag tagttaacga tggcgcgaac ctcggctcgt tgaggttact gcaagccgtt     3600

ccagaggaga tcagggagtt ccggataacg attcgcgcta cagaccaggg aacggaccca     3660

ggaccgctgt ccacggacat gacgttcaga gttgtttttg tgcccacgca aggagaacct     3720

agattcgcgt cctcagaaca tgctgtcgct ttcatagaaa agagtgccgg catggaagag     3780

tctcaccaac ttcctctagc acaagacatc aagaaccatc tctgtgaaga cgactgtcac     3840

agcatttact atcgtattat cgatggcaac agcgagggtc atttcggcct ggatcctgtt     3900

cgcaacaggt tgttcctgaa gaaagagctg ataagagaac aaagtgcctc ccacactctg     3960

caagtggcgg ctagtaactc gcccgatggt ggcattccac ttcctgcttc catccttact     4020

gtcactgtta ccgtgaggga ggcagaccct cgtccagtgt ttatgaggga attgtacacc     4080

gcagggatat ccacagcgga ctccatcggc agagagctgc tcagattaca tgcgacccag     4140

tctgaaggcg cggccattac ttatgctata gactacgata caatggtagt ggaccccagc     4200

ctggaggcag tgagacagtc ggctttcgta ctgaacgctc aaaccggagt gctgacgctt     4260

aatatccagc ccacggccac gatgcatgga ctgttcaaat tcgaagtcac agctactgac     4320

acggccggcg ctcaggaccg caccgacgtc accgtgtacg tggtatcctc gcagaaccgc     4380

gtctacttcg tgttcgtcaa cacgctgcaa caggtcgaag acaacagaga ctttatcgcg     4440

gacaccttca gcgctgggtt caacatgacc tgcaacatcg accaagtggt gcccgccaac     4500

gaccccgtca ccggcgtggc gctggagcac agcacgcaga tgcgcggcca cttcatacgg     4560

gacaacgtac ccgtactcgc tgatgagata gaacagatcc gtagtgacct agtcctcctg     4620

agctcgatac aaacaacgct ggcggcgcga tcgctggtgt tgcaggactt gttgaccaac     4680

tccagcccgg actcggcgcc tgactcgagc ctcacggtgt acgtgctggc ctcactgtct     4740

gctgtgctcg gtttcatgtg ccttgtgcta ctgcttacct tcatcatcag gactagagcg     4800

ctaaaccgac ggttggaagc cctgtcgatg acgaagtacg gctcactgga ctctggattg     4860

aaccgcgccg gcatcgccgc ccccggcacc aacaaacaca ctgtggaagg ctccaaccct     4920

atcttcaatg aagcaataaa gacgccagat ttagatgcca ttagcgaggg ttccaacgac     4980

tctgatctga tcggcatcga agatcttccg cactttggca acgtcttcat ggatcctgag     5040

gtgaacgaaa aggcaaatgg ttatcccgaa gtcgcaaacc acaacaacaa cttcgctttc     5100

aacccgactc ccttctcgcc tgagttcgtt aacggacagt tcagaaagat ctag           5154


<210>  12
<211>  1717
<212>  PRT
<213>  Manduca sexta

<400>  12

Met Ala Val Asp Val Arg Ile Ala Ala Phe Leu Leu Val Phe Ile Ala 
1               5                   10                  15      


Pro Ala Val Leu Ala Gln Glu Arg Cys Gly Tyr Met Thr Ala Ile Pro 
            20                  25                  30          


Arg Leu Pro Arg Pro Asp Asn Leu Pro Val Leu Asn Phe Glu Gly Gln 
        35                  40                  45              


Thr Trp Ser Gln Arg Pro Leu Leu Pro Ala Pro Glu Arg Asp Asp Leu 
    50                  55                  60                  


Cys Met Asp Ala Tyr His Val Ile Thr Ala Asn Leu Gly Thr Gln Val 
65                  70                  75                  80  


Ile Tyr Met Asp Glu Glu Ile Glu Asp Glu Ile Thr Ile Ala Ile Leu 
                85                  90                  95      


Asn Tyr Asn Gly Pro Ser Thr Pro Phe Ile Glu Leu Pro Phe Leu Ser 
            100                 105                 110         


Gly Ser Tyr Asn Leu Leu Met Pro Val Ile Arg Arg Val Asp Asn Gly 
        115                 120                 125             


Glu Trp His Leu Ile Ile Thr Gln Arg Gln Asp Tyr Glu Leu Pro Gly 
    130                 135                 140                 


Met Gln Gln Tyr Met Phe Asn Val Arg Val Asp Gly Gln Ser Leu Val 
145                 150                 155                 160 


Ala Gly Val Ser Leu Ala Ile Val Asn Ile Asp Asp Asn Ala Pro Ile 
                165                 170                 175     


Ile Gln Asn Phe Glu Pro Cys Arg Val Pro Glu Leu Gly Glu Pro Gly 
            180                 185                 190         


Leu Thr Glu Cys Thr Tyr Gln Val Ser Asp Ala Asp Gly Arg Ile Ser 
        195                 200                 205             


Thr Glu Phe Met Thr Phe Arg Ile Asp Ser Val Arg Gly Asp Glu Glu 
    210                 215                 220                 


Thr Phe Tyr Ile Glu Arg Thr Asn Ile Pro Asn Gln Trp Met Trp Leu 
225                 230                 235                 240 


Asn Met Thr Leu Gly Val Asn Thr Ser Leu Asn Phe Val Thr Ser Pro 
                245                 250                 255     


Leu His Ile Phe Ser Val Thr Ala Leu Asp Ser Leu Pro Asn Thr His 
            260                 265                 270         


Thr Val Thr Met Met Val Gln Val Ala Asn Val Asn Ser Arg Pro Pro 
        275                 280                 285             


Arg Trp Leu Glu Ile Phe Ala Val Gln Gln Phe Glu Glu Lys Ser Tyr 
    290                 295                 300                 


Gln Asn Phe Thr Val Arg Ala Ile Asp Gly Asp Thr Glu Ile Asn Met 
305                 310                 315                 320 


Pro Ile Asn Tyr Arg Leu Ile Thr Asn Glu Glu Asp Thr Phe Phe Ser 
                325                 330                 335     


Ile Glu Ala Leu Pro Gly Gly Lys Ser Gly Ala Ile Phe His Val Ser 
            340                 345                 350         


Pro Ile Asp Arg Asp Thr Leu Gln Arg Glu Val Phe Pro Leu Thr Ile 
        355                 360                 365             


Val Ala Tyr Lys Tyr Asp Glu Glu Ala Phe Ser Thr Ser Thr Asn Val 
    370                 375                 380                 


Val Ile Ile Val Thr Asp Ile Asn Asp Gln Arg Pro Glu Pro Ile His 
385                 390                 395                 400 


Lys Glu Tyr Arg Leu Ala Ile Met Glu Glu Thr Pro Met Thr Leu Asn 
                405                 410                 415     


Phe Asp Lys Glu Phe Gly Phe His Asp Lys Asp Leu Gly Gln Asn Ala 
            420                 425                 430         


Gln Tyr Thr Val Arg Leu Glu Ser Val Asp Pro Pro Gly Ala Ala Glu 
        435                 440                 445             


Ala Phe Tyr Ile Ala Pro Glu Val Gly Tyr Gln Arg Gln Thr Phe Ile 
    450                 455                 460                 


Met Gly Thr Leu Asn His Ser Met Leu Asp Tyr Glu Val Pro Glu Phe 
465                 470                 475                 480 


Gln Ser Ile Thr Ile Arg Val Val Ala Thr Asp Asn Asn Asp Thr Arg 
                485                 490                 495     


His Val Gly Val Ala Leu Val His Ile Asp Leu Ile Asn Trp Asn Asp 
            500                 505                 510         


Glu Gln Pro Ile Phe Glu His Ala Val Gln Thr Val Thr Phe Asp Glu 
        515                 520                 525             


Thr Glu Gly Glu Gly Phe Phe Val Ala Lys Ala Val Ala His Asp Arg 
    530                 535                 540                 


Asp Ile Gly Asp Val Val Glu His Thr Leu Leu Gly Asn Ala Val Asn 
545                 550                 555                 560 


Phe Leu Thr Ile Asp Lys Leu Thr Gly Asp Ile Arg Val Ser Ala Asn 
                565                 570                 575     


Asp Ser Phe Asn Tyr His Arg Glu Ser Glu Leu Phe Val Gln Val Arg 
            580                 585                 590         


Ala Thr Asp Thr Leu Gly Glu Pro Phe His Thr Thr Thr Ser Gln Leu 
        595                 600                 605             


Val Ile Arg Leu Asn Asp Ile Asn Asn Thr Pro Pro Thr Leu Arg Leu 
    610                 615                 620                 


Pro Arg Gly Ser Pro Gln Val Glu Glu Asn Val Pro Asp Gly His Val 
625                 630                 635                 640 


Ile Thr Gln Glu Leu Arg Ala Thr Asp Pro Asp Thr Thr Ala Asp Leu 
                645                 650                 655     


Arg Phe Glu Ile Asn Trp Asp Thr Ser Phe Ala Thr Lys Gln Gly Arg 
            660                 665                 670         


Gln Ala Asn Pro Asp Glu Phe Arg Asn Cys Val Glu Ile Glu Thr Ile 
        675                 680                 685             


Phe Pro Glu Ile Asn Asn Arg Gly Leu Ala Ile Gly Arg Val Val Ala 
    690                 695                 700                 


Arg Glu Ile Arg His Asn Val Thr Ile Asp Tyr Glu Glu Phe Glu Val 
705                 710                 715                 720 


Leu Ser Leu Thr Val Arg Val Arg Asp Leu Asn Thr Val Tyr Gly Asp 
                725                 730                 735     


Asp Tyr Asp Glu Ser Met Leu Thr Ile Thr Ile Ile Asp Met Asn Asp 
            740                 745                 750         


Asn Ala Pro Val Trp Val Glu Gly Thr Leu Glu Gln Asn Phe Arg Val 
        755                 760                 765             


Arg Glu Met Ser Ala Gly Gly Leu Val Val Gly Ser Val Arg Ala Asp 
    770                 775                 780                 


Asp Ile Asp Gly Pro Leu Tyr Asn Gln Val Arg Tyr Thr Ile Phe Pro 
785                 790                 795                 800 


Arg Glu Asp Thr Asp Lys Asp Leu Ile Met Ile Asp Phe Leu Thr Gly 
                805                 810                 815     


Gln Ile Ser Val Asn Thr Ser Gly Ala Ile Asp Ala Asp Thr Pro Pro 
            820                 825                 830         


Arg Phe His Leu Tyr Tyr Thr Val Val Ala Ser Asp Arg Cys Ser Thr 
        835                 840                 845             


Glu Asp Pro Ala Asp Cys Pro Pro Asp Pro Thr Tyr Trp Glu Thr Glu 
    850                 855                 860                 


Gly Asn Ile Thr Ile His Ile Thr Asp Thr Asn Asn Lys Val Pro Gln 
865                 870                 875                 880 


Ala Glu Thr Thr Lys Phe Asp Thr Val Val Tyr Ile Tyr Glu Asn Ala 
                885                 890                 895     


Thr His Leu Asp Glu Val Val Thr Leu Ile Ala Ser Asp Leu Asp Arg 
            900                 905                 910         


Asp Glu Ile Tyr His Thr Val Ser Tyr Val Ile Asn Tyr Ala Val Asn 
        915                 920                 925             


Pro Arg Leu Met Asn Phe Phe Ser Val Asn Arg Glu Thr Gly Leu Val 
    930                 935                 940                 


Tyr Val Asp Tyr Glu Thr Gln Gly Ser Gly Glu Val Leu Asp Arg Asp 
945                 950                 955                 960 


Gly Asp Glu Pro Thr His Arg Ile Phe Phe Asn Leu Ile Asp Asn Phe 
                965                 970                 975     


Met Gly Glu Gly Glu Gly Asn Arg Asn Gln Asn Asp Thr Glu Val Leu 
            980                 985                 990         


Val Ile Leu Leu Asp Val Asn Asp  Asn Ala Pro Glu Leu  Pro Pro Pro 
        995                 1000                 1005             


Ser Glu  Leu Ser Trp Thr Ile  Ser Glu Asn Leu Lys  Gln Gly Val 
    1010                 1015                 1020             


Arg Leu  Glu Pro His Ile Phe  Ala Pro Asp Arg Asp  Glu Pro Asp 
    1025                 1030                 1035             


Thr Asp  Asn Ser Arg Val Gly  Tyr Glu Ile Leu Asn  Leu Ser Thr 
    1040                 1045                 1050             


Glu Arg  Asp Ile Glu Val Pro  Glu Leu Phe Val Met  Ile Gln Ile 
    1055                 1060                 1065             


Ala Asn  Val Thr Gly Glu Leu  Glu Thr Ala Met Asp  Leu Lys Gly 
    1070                 1075                 1080             


Tyr Trp  Gly Thr Tyr Ala Ile  His Ile Arg Ala Phe  Asp His Gly 
    1085                 1090                 1095             


Ile Pro  Gln Met Ser Met Asn  Glu Thr Tyr Glu Leu  Ile Ile His 
    1100                 1105                 1110             


Pro Phe  Asn Tyr Tyr Ala Pro  Glu Phe Val Phe Pro  Thr Asn Asp 
    1115                 1120                 1125             


Ala Val  Ile Arg Leu Ala Arg  Glu Arg Ala Val Ile  Asn Gly Val 
    1130                 1135                 1140             


Leu Ala  Thr Val Asn Gly Glu  Phe Leu Glu Arg Ile  Ser Ala Thr 
    1145                 1150                 1155             


Asp Pro  Asp Gly Leu His Ala  Gly Val Val Thr Phe  Gln Val Val 
    1160                 1165                 1170             


Gly Asp  Glu Glu Ser Gln Arg  Tyr Phe Gln Val Val  Asn Asp Gly 
    1175                 1180                 1185             


Ala Asn  Leu Gly Ser Leu Arg  Leu Leu Gln Ala Val  Pro Glu Glu 
    1190                 1195                 1200             


Ile Arg  Glu Phe Arg Ile Thr  Ile Arg Ala Thr Asp  Gln Gly Thr 
    1205                 1210                 1215             


Asp Pro  Gly Pro Leu Ser Thr  Asp Met Thr Phe Arg  Val Val Phe 
    1220                 1225                 1230             


Val Pro  Thr Gln Gly Glu Pro  Arg Phe Ala Ser Ser  Glu His Ala 
    1235                 1240                 1245             


Val Ala  Phe Ile Glu Lys Ser  Ala Gly Met Glu Glu  Ser His Gln 
    1250                 1255                 1260             


Leu Pro  Leu Ala Gln Asp Ile  Lys Asn His Leu Cys  Glu Asp Asp 
    1265                 1270                 1275             


Cys His  Ser Ile Tyr Tyr Arg  Ile Ile Asp Gly Asn  Ser Glu Gly 
    1280                 1285                 1290             


His Phe  Gly Leu Asp Pro Val  Arg Asn Arg Leu Phe  Leu Lys Lys 
    1295                 1300                 1305             


Glu Leu  Ile Arg Glu Gln Ser  Ala Ser His Thr Leu  Gln Val Ala 
    1310                 1315                 1320             


Ala Ser  Asn Ser Pro Asp Gly  Gly Ile Pro Leu Pro  Ala Ser Ile 
    1325                 1330                 1335             


Leu Thr  Val Thr Val Thr Val  Arg Glu Ala Asp Pro  Arg Pro Val 
    1340                 1345                 1350             


Phe Met  Arg Glu Leu Tyr Thr  Ala Gly Ile Ser Thr  Ala Asp Ser 
    1355                 1360                 1365             


Ile Gly  Arg Glu Leu Leu Arg  Leu His Ala Thr Gln  Ser Glu Gly 
    1370                 1375                 1380             


Ala Ala  Ile Thr Tyr Ala Ile  Asp Tyr Asp Thr Met  Val Val Asp 
    1385                 1390                 1395             


Pro Ser  Leu Glu Ala Val Arg  Gln Ser Ala Phe Val  Leu Asn Ala 
    1400                 1405                 1410             


Gln Thr  Gly Val Leu Thr Leu  Asn Ile Gln Pro Thr  Ala Thr Met 
    1415                 1420                 1425             


His Gly  Leu Phe Lys Phe Glu  Val Thr Ala Thr Asp  Thr Ala Gly 
    1430                 1435                 1440             


Ala Gln  Asp Arg Thr Asp Val  Thr Val Tyr Val Val  Ser Ser Gln 
    1445                 1450                 1455             


Asn Arg  Val Tyr Phe Val Phe  Val Asn Thr Leu Gln  Gln Val Glu 
    1460                 1465                 1470             


Asp Asn  Arg Asp Phe Ile Ala  Asp Thr Phe Ser Ala  Gly Phe Asn 
    1475                 1480                 1485             


Met Thr  Cys Asn Ile Asp Gln  Val Val Pro Ala Asn  Asp Pro Val 
    1490                 1495                 1500             


Thr Gly  Val Ala Leu Glu His  Ser Thr Gln Met Arg  Gly His Phe 
    1505                 1510                 1515             


Ile Arg  Asp Asn Val Pro Val  Leu Ala Asp Glu Ile  Glu Gln Ile 
    1520                 1525                 1530             


Arg Ser  Asp Leu Val Leu Leu  Ser Ser Ile Gln Thr  Thr Leu Ala 
    1535                 1540                 1545             


Ala Arg  Ser Leu Val Leu Gln  Asp Leu Leu Thr Asn  Ser Ser Pro 
    1550                 1555                 1560             


Asp Ser  Ala Pro Asp Ser Ser  Leu Thr Val Tyr Val  Leu Ala Ser 
    1565                 1570                 1575             


Leu Ser  Ala Val Leu Gly Phe  Met Cys Leu Val Leu  Leu Leu Thr 
    1580                 1585                 1590             


Phe Ile  Ile Arg Thr Arg Ala  Leu Asn Arg Arg Leu  Glu Ala Leu 
    1595                 1600                 1605             


Ser Met  Thr Lys Tyr Gly Ser  Leu Asp Ser Gly Leu  Asn Arg Ala 
    1610                 1615                 1620             


Gly Ile  Ala Ala Pro Gly Thr  Asn Lys His Thr Val  Glu Gly Ser 
    1625                 1630                 1635             


Asn Pro  Ile Phe Asn Glu Ala  Ile Lys Thr Pro Asp  Leu Asp Ala 
    1640                 1645                 1650             


Ile Ser  Glu Gly Ser Asn Asp  Ser Asp Leu Ile Gly  Ile Glu Asp 
    1655                 1660                 1665             


Leu Pro  His Phe Gly Asn Val  Phe Met Asp Pro Glu  Val Asn Glu 
    1670                 1675                 1680             


Lys Ala  Asn Gly Tyr Pro Glu  Val Ala Asn His Asn  Asn Asn Phe 
    1685                 1690                 1695             


Ala Phe  Asn Pro Thr Pro Phe  Ser Pro Glu Phe Val  Asn Gly Gln 
    1700                 1705                 1710             


Phe Arg  Lys Ile 
    1715         


<210>  13
<211>  618
<212>  DNA
<213>  Manduca sexta

<400>  13
gggatatcca cagcggactc catcggcaga gagctgctca gattacatgc gacccagtct       60

gaaggcgcgg ccattactta tgctatagac tacgatacaa tggtagtgga ccccagcctg      120

gaggcagtga gacagtcggc tttcgtactg aacgctcaaa ccggagtgct gacgcttaat      180

atccagccca cggccacgat gcatggactg ttcaaattcg aagtcacagc tactgacacg      240

gccggcgctc aggaccgcac cgacgtcacc gtgtacgtgg tatcctcgca gaaccgcgtc      300

tacttcgtgt tcgtcaacac gctgcaacag gtcgaagaca acagagactt tatcgcggac      360

accttcagcg ctgggttcaa catgacctgc aacatcgacc aagtggtgcc cgccaacgac      420

cccgtcaccg gcgtggcgct ggagcacagc acgcagatgc gcggccactt catacgggac      480

aacgtacccg tactcgctga tgagatagaa cagatccgta gtgacctagt cctcctgagc      540

tcgatacaaa caacgctggc ggcgcgatcg ctggtgttgc aggacttgtt gaccaactcc      600

agcccggact cggcgcct                                                    618


<210>  14
<211>  206
<212>  PRT
<213>  Manduca sexta

<400>  14

Gly Ile Ser Thr Ala Asp Ser Ile Gly Arg Glu Leu Leu Arg Leu His 
1               5                   10                  15      


Ala Thr Gln Ser Glu Gly Ala Ala Ile Thr Tyr Ala Ile Asp Tyr Asp 
            20                  25                  30          


Thr Met Val Val Asp Pro Ser Leu Glu Ala Val Arg Gln Ser Ala Phe 
        35                  40                  45              


Val Leu Asn Ala Gln Thr Gly Val Leu Thr Leu Asn Ile Gln Pro Thr 
    50                  55                  60                  


Ala Thr Met His Gly Leu Phe Lys Phe Glu Val Thr Ala Thr Asp Thr 
65                  70                  75                  80  


Ala Gly Ala Gln Asp Arg Thr Asp Val Thr Val Tyr Val Val Ser Ser 
                85                  90                  95      


Gln Asn Arg Val Tyr Phe Val Phe Val Asn Thr Leu Gln Gln Val Glu 
            100                 105                 110         


Asp Asn Arg Asp Phe Ile Ala Asp Thr Phe Ser Ala Gly Phe Asn Met 
        115                 120                 125             


Thr Cys Asn Ile Asp Gln Val Val Pro Ala Asn Asp Pro Val Thr Gly 
    130                 135                 140                 


Val Ala Leu Glu His Ser Thr Gln Met Arg Gly His Phe Ile Arg Asp 
145                 150                 155                 160 


Asn Val Pro Val Leu Ala Asp Glu Ile Glu Gln Ile Arg Ser Asp Leu 
                165                 170                 175     


Val Leu Leu Ser Ser Ile Gln Thr Thr Leu Ala Ala Arg Ser Leu Val 
            180                 185                 190         


Leu Gln Asp Leu Leu Thr Asn Ser Ser Pro Asp Ser Ala Pro 
        195                 200                 205     


<210>  15
<211>  8
<212>  PRT
<213>  Heliothis virescens

<400>  15

Gly Val Leu Thr Leu Asn Phe Gln 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Manduca sexta

<400>  16

Gly Val Leu Thr Leu Asn Ile Gln 
1               5               


<210>  17
<211>  10
<212>  PRT
<213>  Anopheles gambiae

<400>  17

Gly Glu Leu Thr Leu Thr Ser Lys Val Gln 
1               5                   10  


<210>  18
<211>  32
<212>  DNA
<213>  Anopheles gambiae

<400>  18
ggtggccgct ggtcgatcgt aatcaatcgc cg                                     32


<210>  19
<211>  33
<212>  DNA
<213>  Anopheles gambiae

<400>  19
cttaattttc agtgtccacg ttccgtaaaa tcc                                    33


<210>  20
<211>  33
<212>  DNA
<213>  Anopheles gambiae

<400>  20
cgtgtatcgt tcacgatcaa catcaacaat gcg                                    33


<210>  21
<211>  29
<212>  DNA
<213>  Anopheles gambiae

<400>  21
atcatcgctc acgacattga cggaccagg                                         29


<210>  22
<211>  32
<212>  DNA
<213>  Anopheles gambiae

<400>  22
gcaccctcgc tggaggtgtt cagcagccgg tt                                     32


<210>  23
<211>  32
<212>  DNA
<213>  Anopheles gambiae

<400>  23
ggtcccgcgc accggccaca tcaccgatct cg                                     32


<210>  24
<211>  33
<212>  DNA
<213>  Anopheles gambiae

<400>  24
gttacctagt gtaccggctg ctggcggcct taa                                    33


<210>  25
<211>  31
<212>  DNA
<213>  Anopheles gambiae

<400>  25
cgttcgtctc agcgcccggg ggaaggcccg c                                      31


<210>  26
<211>  30
<212>  DNA
<213>  Anopheles gambiae

<400>  26
ccgtttgccg aggatccgaa gaacgcgggc                                        30


<210>  27
<211>  36
<212>  DNA
<213>  Anopheles gambiae

<400>  27
gaattcgcgg ccgcgggaat tttttttttt tttttt                                 36


<210>  28
<211>  35
<212>  DNA
<213>  Anopheles gambiae

<400>  28
gacccatatg gacgaaacgc tgcagatcat cctga                                  35


<210>  29
<211>  35
<212>  DNA
<213>  Anopheles gambiae

<400>  29
acacctcgag gaaccggtgg gacagctcgt cgtca                                  35


<210>  30
<211>  21
<212>  DNA
<213>  Anopheles gambiae

<400>  30
ggtatctcaa cgtcgtcgct g                                                 21


<210>  31
<211>  20
<212>  DNA
<213>  Anopheles gambiae

<400>  31
cctccagcac ggagttgttc                                                   20


<210>  32
<211>  30
<212>  DNA
<213>  Anopheles gambiae

<400>  32
cgagcatatg gggtccccgt tgccgaaatt                                        30


<210>  33
<211>  32
<212>  DNA
<213>  Anopheles gambiae

<400>  33
cgctctcgag aaacacgaac gtcacgcggt tc                                     32


<210>  34
<211>  35
<212>  DNA
<213>  Anopheles gambiae

<400>  34
ttcaccatgg gtatctcaac gtcgtcgctg ttcgg                                  35


<210>  35
<211>  35
<212>  DNA
<213>  Anopheles gambiae

<400>  35
catactcgag tgacggacag ctcgtccatc tctgc                                  35


<210>  36
<211>  35
<212>  DNA
<213>  Manduca sexta

<400>  36
gtaccatatg gggatatcca cagcggactc catcg                                  35


<210>  37
<211>  35
<212>  DNA
<213>  Manduca sexta

<400>  37
ggctctcgag aggcgccgag tccgggctgg agttg                                  35


