1
SEQUENCE LISTING
<110> Elevation Biotech Pty Ltd.
National Health Laboratory Service
University of Witwatersrand
<120> CD4 POLYPEPTIDES AND METHODS OF USE
<130> 23795-0003WO1
<150> US 61/040,128
<151> 2008-03-27
<160> 33
<170> FastSEQ for Windows Version 4.0
<210> 1
<211> 7
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 1, 3
<223> Xaa = any amino acid
<220>
<221> VARIANT
<222> 5
<223> Xaa = Trp, Phe, or Tyr
<400> 1
Xaa Arg Xaa Leu Xaa Asp Gln
1 5
<210> 2
<211> 7
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<400> 2
Arg Arg Cys Leu Trp Asp Gln
1 5
<210> 3
<211> 7
2
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 3
<223> Xaa = selenocysteine
<400> 3
Arg Arg Xaa Leu Trp Asp Gln
1 5
<210> 4
<211> 7
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<400> 4
Cys Arg Ser Leu Trp Asp Gln
1 5
<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 1
<223> Xaa = selenocysteine
<400> 5
Xaa Arg Ser Leu Trp Asp Gln
1 5
<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<400> 6
Cys Arg Cys Leu Trp Asp Gln
3
1 5
<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 1, 3
<223> Xaa = selenocysteine
<400> 7
Xaa Arg Xaa Leu Trp Asp Gln
1 5
<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 3
<223> Xaa = selenocysteine
<400> 8
Cys Arg Xaa Leu Trp Asp Gln
1 5
<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 1
<223> Xaa = selenocysteine
<400> 9
Xaa Arg Cys Leu Trp Asp Gln
1 5
4
<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<400> 10
Arg Arg Ser Leu Trp Asp Gln
1 5
<210> 11
<211> 5
<212> PRT
<213> Homo sapiens
<400> 11
Arg Arg Cys Leu Trp
1 5
<210> 12
<211> 5
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 1, 3
<223> Xaa = any amino acid
<220>
<221> VARIANT
<222> 5
<223> Xaa = Trp, Phe, or Tyr
<400> 12
Xaa Arg Xaa Leu Xaa
1 5
<210> 13
<211> 57
<212> PRT
<213> Homo sapiens
<400> 13
Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys
1 5 10 15
Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn
20 25 30
Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro
5
35 40 45
Ser Lys Leu Asn Asp Arg Ala Asp Ser
50 55
<210> 14
<211> 82
<212> PRT
<213> Homo sapiens
<400> 14
Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu
1 5 10 15
Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys
20 25 30
Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser
35 40 45
Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn
50 55 60
Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala
65 70 75 80
Asp Ser
<210> 15
<211> 8
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 4
<223> Xaa = Cysteine or selenocysteine
<400> 15
Ser Arg Arg Xaa Leu Trp Asp Gln
1 5
<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 5
<223> Xaa = Cysteine or selenocysteine
<400> 16
6
Asp Ser Arg Arg Xaa Leu Trp Asp Gln
1 5
<210> 17
<211> 10
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 6
<223> Xaa = Cysteine or selenocysteine
<400> 17
Ala Asp Ser Arg Arg Xaa Leu Trp Asp Gln
1 5 10
<210> 18
<211> 369
<212> PRT
<213> Homo sapiens
<400> 18
Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp
1 5 10 15
Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu
20 25 30
Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln
35 40 45
Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val
50 55 60
Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu
65 70 75 80
Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr
85 90 95
Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val
100 105 110
Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu
115 120 125
Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr
130 135 140
Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys
145 150 155 160
Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg
165 170 175
Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His
180 185 190
Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu
195 200 205
Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn
210 215 220
Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu
7
225 230 235 240
Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu Lys Leu Glu
245 250 255
Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val Trp Val Leu
260 265 270
Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp Ser Gly Gln
275 280 285
Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro
290 295 300
Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu
305 310 315 320
Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg
325 330 335
Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu
340 345 350
Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro
355 360 365
Ile
<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 3
<223> Xaa = Cysteine or selenocysteine
<400> 19
Arg Arg Xaa Leu Trp Asp Gln Gly
1 5
<210> 20
<211> 9
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 3
<223> Xaa = Cysteine or selenocysteine
<400> 20
Arg Arg Xaa Leu Trp Asp Gln Gly Asn
1 5
<210> 21
8
<211> 10
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 3
<223> Xaa = Cysteine or selenocysteine
<400> 21
Arg Arg Xaa Leu Trp Asp Gln Gly Asn Phe
1 5 10
<210> 22
<211> 458
<212> PRT
<213> Homo sapiens
<400> 22
Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu
1 5 10 15
Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys
20 25 30
Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser
35 40 45
Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn
50 55 60
Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala
65 70 75 80
Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile
85 90 95
Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu
100 105 110
Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn
115 120 125
Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu
130 135 140
Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly
145 150 155 160
Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu
165 170 175
Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys
180 185 190
Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser
195 200 205
Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro
210 215 220
Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp
225 230 235 240
Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu
245 250 255
Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu
260 265 270
9
Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu
275 280 285
Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys
290 295 300
Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr
305 310 315 320
Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro
325 330 335
Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser
340 345 350
Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp
355 360 365
Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile
370 375 380
Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile
385 390 395 400
Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile
405 410 415
Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met
420 425 430
Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro
435 440 445
His Arg Phe Gln Lys Thr Cys Ser Pro Ile
450 455
<210> 23
<211> 458
<212> PRT
<213> Homo sapiens
<220>
<221> MUTANT
<222> 85
<223> Serine to Cysteine substitution
<400> 23
Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu
1 5 10 15
Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys
20 25 30
Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser
35 40 45
Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn
50 55 60
Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala
65 70 75 80
Asp Ser Arg Arg Cys Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile
85 90 95
Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu
100 105 110
Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn
115 120 125
Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu
130 135 140
Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly
145 150 155 160
10
Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu
165 170 175
Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys
180 185 190
Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser
195 200 205
Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro
210 215 220
Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp
225 230 235 240
Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu
245 250 255
Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu
260 265 270
Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu
275 280 285
Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys
290 295 300
Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr
305 310 315 320
Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro
325 330 335
Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser
340 345 350
Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp
355 360 365
Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile
370 375 380
Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile
385 390 395 400
Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile
405 410 415
Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met
420 425 430
Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro
435 440 445
His Arg Phe Gln Lys Thr Cys Ser Pro Ile
450 455
<210> 24
<211> 856
<212> PRT
<213> Human immunodeficiency virus 1
<400> 24
Met Arg Val Lys Glu Lys Tyr Gln His Leu Trp Arg Trp Gly Trp Arg
1 5 10 15
Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Thr Glu
20 25 30
Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala
35 40 45
Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu
50 55 60
Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn
65 70 75 80
Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp
11
85 90 95
Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp
100 105 110
Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ser
115 120 125
Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr Asn Ser Ser Ser
130 135 140
Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn
145 150 155 160
Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu Tyr Ala Phe Phe
165 170 175
Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr Thr Ser Tyr Lys
180 185 190
Leu Thr Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val
195 200 205
Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala
210 215 220
Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr
225 230 235 240
Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser
245 250 255
Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile
260 265 270
Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu
275 280 285
Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg
290 295 300
Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile
305 310 315 320
Gly Lys Ile Gly Asn Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala
325 330 335
Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln
340 345 350
Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp
355 360 365
Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr
370 375 380
Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp
385 390 395 400
Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu
405 410 415
Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys
420 425 430
Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn
435 440 445
Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu
450 455 460
Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg
465 470 475 480
Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val
485 490 495
Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala
500 505 510
Val Gly Ile Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser
515 520 525
Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu
530 535 540
12
Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu
545 550 555 560
Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu
565 570 575
Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu
580 585 590
Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val
595 600 605
Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn
610 615 620
His Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser
625 630 635 640
Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn
645 650 655
Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp
660 665 670
Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Leu Phe Ile Met Ile
675 680 685
Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile
690 695 700
Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His
705 710 715 720
Leu Pro Thr Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu
725 730 735
Gly Gly Glu Arg Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Ser
740 745 750
Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr
755 760 765
His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu
770 775 780
Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu
785 790 795 800
Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn
805 810 815
Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val
820 825 830
Val Gln Gly Ala Cys Arg Ala Ile Arg His Ile Pro Arg Arg Ile Arg
835 840 845
Gln Gly Leu Glu Arg Ile Leu Leu
850 855
<210> 25
<211> 483
<212> PRT
<213> Human immunodeficiency virus 1
<400> 25
Ser Ala Thr Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val
1 5 10 15
Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala
20 25 30
Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro
35 40 45
Thr Asp Pro Asn Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn
50 55 60
Phe Asn Met Trp Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile
13
65 70 75 80
Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro
85 90 95
Leu Cys Val Ser Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr
100 105 110
Asn Ser Ser Ser Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn
115 120 125
Cys Ser Phe Asn Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu
130 135 140
Tyr Ala Phe Phe Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr
145 150 155 160
Thr Ser Tyr Lys Leu Thr Ser Cys Asn Thr Ser Val Ile Thr Gln Ala
165 170 175
Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro
180 185 190
Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr
195 200 205
Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg
210 215 220
Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu
225 230 235 240
Glu Val Val Ile Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile
245 250 255
Ile Val Gln Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Asn
260 265 270
Asn Asn Thr Arg Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala
275 280 285
Phe Val Thr Ile Gly Lys Ile Gly Asn Met Arg Gln Ala His Cys Asn
290 295 300
Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys
305 310 315 320
Leu Arg Glu Gln Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser
325 330 335
Ser Gly Gly Asp Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly
340 345 350
Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe
355 360 365
Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp
370 375 380
Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln
385 390 395 400
Lys Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg
405 410 415
Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn
420 425 430
Ser Asn Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg
435 440 445
Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu
450 455 460
Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg
465 470 475 480
Glu Lys Arg
<210> 26
<211> 3103
14
<212> DNA
<213> Homo sapiens
<400> 26
ccaggcctag ggtgtggagg agccttgcca tcgggcttcc tgtctctctt catttaagca 60
cgactctgca gaaggaacaa agcaccctcc ccactgggct cctggttgca gagctccaag 120
tcctcacaca gatacgcctg tttgagaagc agcgggcaag aaagacgcaa gcccagaggc 180
cctgccattt ctgtgggctc aggtccctac tggctcaggc ccctgcctcc ctcggcaagg 240
ccacaatgaa ccggggagtc ccttttaggc acttgcttct ggtgctgcaa ctggcgctcc 300
tcccagcagc cactcaggga aagaaagtgg tgctgggcaa aaaaggggat acagtggaac 360
tgacctgtac agcttcccag aagaagagca tacaattcca ctggaaaaac tccaaccaga 420
taaagattct gggaaatcag ggctccttct taactaaagg tccatccaag ctgaatgatc 480
gcgctgactc aagaagaagc ctttgggacc aaggaaactt tcccctgatc atcaagaatc 540
ttaagataga agactcagat acttacatct gtgaagtgga ggaccagaag gaggaggtgc 600
aattgctagt gttcggattg actgccaact ctgacaccca cctgcttcag gggcagagcc 660
tgaccctgac cttggagagc ccccctggta gtagcccctc agtgcaatgt aggagtccaa 720
ggggtaaaaa catacagggg gggaagaccc tctccgtgtc tcagctggag ctccaggata 780
gtggcacctg gacatgcact gtcttgcaga accagaagaa ggtggagttc aaaatagaca 840
tcgtggtgct agctttccag aaggcctcca gcatagtcta taagaaagag ggggaacagg 900
tggagttctc cttcccactc gcctttacag ttgaaaagct gacgggcagt ggcgagctgt 960
ggtggcaggc ggagagggct tcctcctcca agtcttggat cacctttgac ctgaagaaca 1020
aggaagtgtc tgtaaaacgg gttacccagg accctaagct ccagatgggc aagaagctcc 1080
cgctccacct caccctgccc caggccttgc ctcagtatgc tggctctgga aacctcaccc 1140
tggcccttga agcgaaaaca ggaaagttgc atcaggaagt gaacctggtg gtgatgagag 1200
ccactcagct ccagaaaaat ttgacctgtg aggtgtgggg acccacctcc cctaagctga 1260
tgctgagttt gaaactggag aacaaggagg caaaggtctc gaagcgggag aaggcggtgt 1320
gggtgctgaa ccctgaggcg gggatgtggc agtgtctgct gagtgactcg ggacaggtcc 1380
tgctggaatc caacatcaag gttctgccca catggtccac cccggtgcag ccaatggccc 1440
tgattgtgct ggggggcgtc gccggcctcc tgcttttcat tgggctaggc atcttcttct 1500
gtgtcaggtg ccggcaccga aggcgccaag cagagcggat gtctcagatc aagagactcc 1560
tcagtgagaa gaagacctgc cagtgtcctc accggtttca gaagacatgt agccccattt 1620
gaggcacgag gccaggcaga tcccacttgc agcctcccca ggtgtctgcc ccgcgtttcc 1680
tgcctgcgga ccagatgaat gtagcagatc cccagcctct ggcctcctgt tcgcctcctc 1740
tacaatttgc cattgtttct cctgggttag gccccggctt cactggttga gtgttgctct 1800
ctagtttcca gaggcttaat cacaccgtcc tccacgccat ttccttttcc ttcaagccta 1860
gcccttctct cattatttct ctctgaccct ctccccactg ctcatttgga tcccagggga 1920
gtgttcaggg ccagccctgg ctggcatgga gggtgaggct gggtgtctgg aagcatggag 1980
catgggactg ttcttttaca agacaggacc ctgggaccac agagggcagg aacttgcaca 2040
aaatcacaca gccaagccag tcaaggatgg atgcagatcc agaggtttct ggcagccagt 2100
acctcctgcc ccatgctgcc cgcttctcac cctatgtggg tgggaccaca gactcacatc 2160
ctgaccttgc acaaacagcc cctctggaca cagccccatg tacacggcct caagggatgt 2220
ctcacatcct ctgtctattt gagacttaga aaaatcctac aaggctggca gtgacagaac 2280
taagatgatc atctccagtt tatagaccag aaccagagct cagagaggct agatgattga 2340
ttaccaagtg ccggactagc aagtgctgga gtcgggacta acccaggtcc cttgtcccaa 2400
gttccactgc tgcctcttga atgcagggac aaatgccaca cggctctcac cagtggctag 2460
tggtgggtac tcaatgtgta cttttgggtt cacagaagca cagcacccat gggaagggtc 2520
catctcagag aatttacgag cagggatgaa ggcctccctg tctaaaatcc ctccttcatc 2580
ccccgctggt ggcagaatct gttaccagag gacaaagcct ttggctcttc taatcagagc 2640
gcaagctggg agcacaggca ctgcaggaga gaatgcccag tgaccagtca ctgaccctgt 2700
gcagaacctc ctggaagcga gctttgctgg gagagggggt agctagcctg agagggaacc 2760
ctctaaggga cctcaaaggt gattgtgcca ggctctgcgc ctgccccaca ccctccctta 2820
ccctcctcca gaccattcag gacacaggga aatcagggtt acaaatcttc ttgatccact 2880
tctctcagga tcccctctct tcctaccctt cctcaccact tccctcagtc ccaactcctt 2940
ttccctattt ccttctcctc ctgtctttaa agcctgcctc ttccaggaag acccccctat 3000
tgctgctggg gctccccatt tgcttacttt gcatttgtgc ccactctcca cccctgctcc 3060
cctgagctga aataaaaata caataaactt actataaaga tgc 3103
15
<210> 27
<211> 7
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<400> 27
Asp Leu Arg Gln Cys Trp Arg
1 5
<210> 28
<211> 12
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<400> 28
Arg Ile Asn Asn Ile Pro Trp Ser Glu Ala Met Met
1 5 10
<210> 29
<211> 99
<212> PRT
<213> Homo sapiens
<400> 29
Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys
1 5 10 15
Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn
20 25 30
Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro
35 40 45
Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln
50 55 60
Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp
65 70 75 80
Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu
85 90 95
Val Phe Gly
<210> 30
<211> 99
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
16
<222> 60
<223> Xaa = selenocysteine
<400> 30
Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys
1 5 10 15
Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn
20 25 30
Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro
35 40 45
Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Xaa Leu Trp Asp Gln
50 55 60
Val Ala Gly Leu His Leu Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp
65 70 75 80
Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu
85 90 95
Val Phe Gly
<210> 31
<211> 99
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 60
<223> Xaa = selenocysteine
<400> 31
Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys
1 5 10 15
Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn
20 25 30
Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro
35 40 45
Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Xaa Leu Trp Asp Gly
50 55 60
Leu Gln Val Cys Thr Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp
65 70 75 80
Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu
85 90 95
Val Phe Gly
<210> 32
<211> 99
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
17
<220>
<221> VARIANT
<222> 60
<223> Xaa = selenocysteine
<400> 32
Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys
1 5 10 15
Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn
20 25 30
Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro
35 40 45
Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Xaa Leu Trp Asp Gln
50 55 60
Val Pro Gly Leu Val Gln Asn Leu Glu Ile Lys Ile Glu Asp Ser Asp
65 70 75 80
Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu
85 90 95
Val Phe Gly
<210> 33
<211> 100
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetically generated peptide
<220>
<221> VARIANT
<222> 60
<223> Xaa = selenocysteine
<400> 33
Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys
1 5 10 15
Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn
20 25 30
Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro
35 40 45
Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Xaa His Asp Gln Gly
50 55 60
Gly Val Pro Gly Leu Val Arg Asn Leu Lys Ile Lys Ile Glu Asp Ser
65 70 75 80
Asp Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu
85 90 95
Leu Val Phe Gly
100