
                                SEQUENCE LISTING

<110> Doudna, Jennifer A.
      Ma, Enbo
      MacRae, Ian J.

<120> Modified Dicer polypeptide and methods
  of use thereof

<130> BERK-083 WO

<150> 61/070,286          
<151> 2008-03-21  

<160> 25

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1922
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Ser Pro Ala Leu Gln Pro Leu Ser Met Ala Gly Leu Gln Leu
 1               5                  10                  15      
Met Thr Pro Ala Ser Ser Pro Met Gly Pro Phe Phe Gly Leu Pro Trp
            20                  25                  30          
Gln Gln Glu Ala Ile His Asp Asn Ile Tyr Thr Pro Arg Lys Tyr Gln
        35                  40                  45              
Val Glu Leu Leu Glu Ala Ala Leu Asp His Asn Thr Ile Val Cys Leu
    50                  55                  60                  
Asn Thr Gly Ser Gly Lys Thr Phe Ile Ala Val Leu Leu Thr Lys Glu
65                  70                  75                  80  
Leu Ser Tyr Gln Ile Arg Gly Asp Phe Ser Arg Asn Gly Lys Arg Thr
                85                  90                  95      
Val Phe Leu Val Asn Ser Ala Asn Gln Val Ala Gln Gln Val Ser Ala
            100                 105                 110         
Val Arg Thr His Ser Asp Leu Lys Val Gly Glu Tyr Ser Asn Leu Glu
        115                 120                 125             
Val Asn Ala Ser Trp Thr Lys Glu Arg Trp Asn Gln Glu Phe Thr Lys
    130                 135                 140                 
His Gln Val Leu Ile Met Thr Cys Tyr Val Ala Leu Asn Val Leu Lys
145                 150                 155                 160 
Asn Gly Tyr Leu Ser Leu Ser Asp Ile Asn Leu Leu Val Phe Asp Glu
                165                 170                 175     
Cys His Leu Ala Ile Leu Asp His Pro Tyr Arg Glu Ile Met Lys Leu
            180                 185                 190         
Cys Glu Asn Cys Pro Ser Cys Pro Arg Ile Leu Gly Leu Thr Ala Ser
        195                 200                 205             
Ile Leu Asn Gly Lys Cys Asp Pro Glu Glu Leu Glu Glu Lys Ile Gln
    210                 215                 220                 
Lys Leu Glu Lys Ile Leu Lys Ser Asn Ala Glu Thr Ala Thr Asp Leu
225                 230                 235                 240 
Val Val Leu Asp Arg Tyr Thr Ser Gln Pro Cys Glu Ile Val Val Asp
                245                 250                 255     
Cys Gly Pro Phe Thr Asp Arg Ser Gly Leu Tyr Glu Arg Leu Leu Met
            260                 265                 270         
Glu Leu Glu Glu Ala Leu Asn Phe Ile Asn Asp Cys Asn Ile Ser Val
        275                 280                 285             
His Ser Lys Glu Arg Asp Ser Thr Leu Ile Ser Lys Gln Ile Leu Ser
    290                 295                 300                 
Asp Cys Arg Ala Val Leu Val Val Leu Gly Pro Trp Cys Ala Asp Lys
305                 310                 315                 320 
Val Ala Gly Met Met Val Arg Glu Leu Gln Lys Tyr Ile Lys His Glu
                325                 330                 335     
Gln Glu Glu Leu His Arg Lys Phe Leu Leu Phe Thr Asp Thr Phe Leu
            340                 345                 350         
Arg Lys Ile His Ala Leu Cys Glu Glu His Phe Ser Pro Ala Ser Leu
        355                 360                 365             
Asp Leu Lys Phe Val Thr Pro Lys Val Ile Lys Leu Leu Glu Ile Leu
    370                 375                 380                 
Arg Lys Tyr Lys Pro Tyr Glu Arg Gln Gln Phe Glu Ser Val Glu Trp
385                 390                 395                 400 
Tyr Asn Asn Arg Asn Gln Asp Asn Tyr Val Ser Trp Ser Asp Ser Glu
                405                 410                 415     
Asp Asp Asp Glu Asp Glu Glu Ile Glu Glu Lys Glu Lys Pro Glu Thr
            420                 425                 430         
Asn Phe Pro Ser Pro Phe Thr Asn Ile Leu Cys Gly Ile Ile Phe Val
        435                 440                 445             
Glu Arg Arg Tyr Thr Ala Val Val Leu Asn Arg Leu Ile Lys Glu Ala
    450                 455                 460                 
Gly Lys Gln Asp Pro Glu Leu Ala Tyr Ile Ser Ser Asn Phe Ile Thr
465                 470                 475                 480 
Gly His Gly Ile Gly Lys Asn Gln Pro Arg Asn Lys Gln Met Glu Ala
                485                 490                 495     
Glu Phe Arg Lys Gln Glu Glu Val Leu Arg Lys Phe Arg Ala His Glu
            500                 505                 510         
Thr Asn Leu Leu Ile Ala Thr Ser Ile Val Glu Glu Gly Val Asp Ile
        515                 520                 525             
Pro Lys Cys Asn Leu Val Val Arg Phe Asp Leu Pro Thr Glu Tyr Arg
    530                 535                 540                 
Ser Tyr Val Gln Ser Lys Gly Arg Ala Arg Ala Pro Ile Ser Asn Tyr
545                 550                 555                 560 
Ile Met Leu Ala Asp Thr Asp Lys Ile Lys Ser Phe Glu Glu Asp Leu
                565                 570                 575     
Lys Thr Tyr Lys Ala Ile Glu Lys Ile Leu Arg Asn Lys Cys Ser Lys
            580                 585                 590         
Ser Val Asp Thr Gly Glu Thr Asp Ile Asp Pro Val Met Asp Asp Asp
        595                 600                 605             
Asp Val Phe Pro Pro Tyr Val Leu Arg Pro Asp Asp Gly Gly Pro Arg
    610                 615                 620                 
Val Thr Ile Asn Thr Ala Ile Gly His Ile Asn Arg Tyr Cys Ala Arg
625                 630                 635                 640 
Leu Pro Ser Asp Pro Phe Thr His Leu Ala Pro Lys Cys Arg Thr Arg
                645                 650                 655     
Glu Leu Pro Asp Gly Thr Phe Tyr Ser Thr Leu Tyr Leu Pro Ile Asn
            660                 665                 670         
Ser Pro Leu Arg Ala Ser Ile Val Gly Pro Pro Met Ser Cys Val Arg
        675                 680                 685             
Leu Ala Glu Arg Val Val Ala Leu Ile Cys Cys Glu Lys Leu His Lys
    690                 695                 700                 
Ile Gly Glu Leu Asp Asp His Leu Met Pro Val Gly Lys Glu Thr Val
705                 710                 715                 720 
Lys Tyr Glu Glu Glu Leu Asp Leu His Asp Glu Glu Glu Thr Ser Val
                725                 730                 735     
Pro Gly Arg Pro Gly Ser Thr Lys Arg Arg Gln Cys Tyr Pro Lys Ala
            740                 745                 750         
Ile Pro Glu Cys Leu Arg Asp Ser Tyr Pro Arg Pro Asp Gln Pro Cys
        755                 760                 765             
Tyr Leu Tyr Val Ile Gly Met Val Leu Thr Thr Pro Leu Pro Asp Glu
    770                 775                 780                 
Leu Asn Phe Arg Arg Arg Lys Leu Tyr Pro Pro Glu Asp Thr Thr Arg
785                 790                 795                 800 
Cys Phe Gly Ile Leu Thr Ala Lys Pro Ile Pro Gln Ile Pro His Phe
                805                 810                 815     
Pro Val Tyr Thr Arg Ser Gly Glu Val Thr Ile Ser Ile Glu Leu Lys
            820                 825                 830         
Lys Ser Gly Phe Met Leu Ser Leu Gln Met Leu Glu Leu Ile Thr Arg
        835                 840                 845             
Leu His Gln Tyr Ile Phe Ser His Ile Leu Arg Leu Glu Lys Pro Ala
    850                 855                 860                 
Leu Glu Phe Lys Pro Thr Asp Ala Asp Ser Ala Tyr Cys Val Leu Pro
865                 870                 875                 880 
Leu Asn Val Val Asn Asp Ser Ser Thr Leu Asp Ile Asp Phe Lys Phe
                885                 890                 895     
Met Glu Asp Ile Glu Lys Ser Glu Ala Arg Ile Gly Ile Pro Ser Thr
            900                 905                 910         
Lys Tyr Thr Lys Glu Thr Pro Phe Val Phe Lys Leu Glu Asp Tyr Gln
        915                 920                 925             
Asp Ala Val Ile Ile Pro Arg Tyr Arg Asn Phe Asp Gln Pro His Arg
    930                 935                 940                 
Phe Tyr Val Ala Asp Val Tyr Thr Asp Leu Thr Pro Leu Ser Lys Phe
945                 950                 955                 960 
Pro Ser Pro Glu Tyr Glu Thr Phe Ala Glu Tyr Tyr Lys Thr Lys Tyr
                965                 970                 975     
Asn Leu Asp Leu Thr Asn Leu Asn Gln Pro Leu Leu Asp Val Asp His
            980                 985                 990         
Thr Ser Ser Arg Leu Asn Leu Leu Thr Pro Arg His Leu Asn Gln Lys
        995                 1000                1005            
Gly Lys Ala Leu Pro Leu Ser Ser Ala Glu Lys Arg Lys Ala Lys Trp
    1010                1015                1020                
Glu Ser Leu Gln Asn Lys Gln Ile Leu Val Pro Glu Leu Cys Ala Ile
1025                1030                1035                1040
His Pro Ile Pro Ala Ser Leu Trp Arg Lys Ala Val Cys Leu Pro Ser
                1045                1050                1055    
Ile Leu Tyr Arg Leu His Cys Leu Leu Thr Ala Glu Glu Leu Arg Ala
            1060                1065                1070        
Gln Thr Ala Ser Asp Ala Gly Val Gly Val Arg Ser Leu Pro Ala Asp
        1075                1080                1085            
Phe Arg Tyr Pro Asn Leu Asp Phe Gly Trp Lys Lys Ser Ile Asp Ser
    1090                1095                1100                
Lys Ser Phe Ile Ser Ile Ser Asn Ser Ser Ser Ala Glu Asn Asp Asn
1105                1110                1115                1120
Tyr Cys Lys His Ser Thr Ile Val Pro Glu Asn Ala Ala His Gln Gly
                1125                1130                1135    
Ala Asn Arg Thr Ser Ser Leu Glu Asn His Asp Gln Met Ser Val Asn
            1140                1145                1150        
Cys Arg Thr Leu Leu Ser Glu Ser Pro Gly Lys Leu His Val Glu Val
        1155                1160                1165            
Ser Ala Asp Leu Thr Ala Ile Asn Gly Leu Ser Tyr Asn Gln Asn Leu
    1170                1175                1180                
Ala Asn Gly Ser Tyr Asp Leu Ala Asn Arg Asp Phe Cys Gln Gly Asn
1185                1190                1195                1200
Gln Leu Asn Tyr Tyr Lys Gln Glu Ile Pro Val Gln Pro Thr Thr Ser
                1205                1210                1215    
Tyr Ser Ile Gln Asn Leu Tyr Ser Tyr Glu Asn Gln Pro Gln Pro Ser
            1220                1225                1230        
Asp Glu Cys Thr Leu Leu Ser Asn Lys Tyr Leu Asp Gly Asn Ala Asn
        1235                1240                1245            
Lys Ser Thr Ser Asp Gly Ser Pro Val Met Ala Val Met Pro Gly Thr
    1250                1255                1260                
Thr Asp Thr Ile Gln Val Leu Lys Gly Arg Met Asp Ser Glu Gln Ser
1265                1270                1275                1280
Pro Ser Ile Gly Tyr Ser Ser Arg Thr Leu Gly Pro Asn Pro Gly Leu
                1285                1290                1295    
Ile Leu Gln Ala Leu Thr Leu Ser Asn Ala Ser Asp Gly Phe Asn Leu
            1300                1305                1310        
Glu Arg Leu Glu Met Leu Gly Asp Ser Phe Leu Lys His Ala Ile Thr
        1315                1320                1325            
Thr Tyr Leu Phe Cys Thr Tyr Pro Asp Ala His Glu Gly Arg Leu Ser
    1330                1335                1340                
Tyr Met Arg Ser Lys Lys Val Ser Asn Cys Asn Leu Tyr Arg Leu Gly
1345                1350                1355                1360
Lys Lys Lys Gly Leu Pro Ser Arg Met Val Val Ser Ile Phe Asp Pro
                1365                1370                1375    
Pro Val Asn Trp Leu Pro Pro Gly Tyr Val Val Asn Gln Asp Lys Ser
            1380                1385                1390        
Asn Thr Asp Lys Trp Glu Lys Asp Glu Met Thr Lys Asp Cys Met Leu
        1395                1400                1405            
Ala Asn Gly Lys Leu Asp Glu Asp Tyr Glu Glu Glu Asp Glu Glu Glu
    1410                1415                1420                
Glu Ser Leu Met Trp Arg Ala Pro Lys Glu Glu Ala Asp Tyr Glu Asp
1425                1430                1435                1440
Asp Phe Leu Glu Tyr Asp Gln Glu His Ile Arg Phe Ile Asp Asn Met
                1445                1450                1455    
Leu Met Gly Ser Gly Ala Phe Val Lys Lys Ile Ser Leu Ser Pro Phe
            1460                1465                1470        
Ser Thr Thr Asp Ser Ala Tyr Glu Trp Lys Met Pro Lys Lys Ser Ser
        1475                1480                1485            
Leu Gly Ser Met Pro Phe Ser Ser Asp Phe Glu Asp Phe Asp Tyr Ser
    1490                1495                1500                
Ser Trp Asp Ala Met Cys Tyr Leu Asp Pro Ser Lys Ala Val Glu Glu
1505                1510                1515                1520
Asp Asp Phe Val Val Gly Phe Trp Asn Pro Ser Glu Glu Asn Cys Gly
                1525                1530                1535    
Val Asp Thr Gly Lys Gln Ser Ile Ser Tyr Asp Leu His Thr Glu Gln
            1540                1545                1550        
Cys Ile Ala Asp Lys Ser Ile Ala Asp Cys Val Glu Ala Leu Leu Gly
        1555                1560                1565            
Cys Tyr Leu Thr Ser Cys Gly Glu Arg Ala Ala Gln Leu Phe Leu Cys
    1570                1575                1580                
Ser Leu Gly Leu Lys Val Leu Pro Val Ile Lys Arg Thr Asp Arg Glu
1585                1590                1595                1600
Lys Ala Leu Cys Pro Thr Arg Glu Asn Phe Asn Ser Gln Gln Lys Asn
                1605                1610                1615    
Leu Ser Val Ser Cys Ala Ala Ala Ser Val Ala Ser Ser Arg Ser Ser
            1620                1625                1630        
Val Leu Lys Asp Ser Glu Tyr Gly Cys Leu Lys Ile Pro Pro Arg Cys
        1635                1640                1645            
Met Phe Asp His Pro Asp Ala Asp Lys Thr Leu Asn His Leu Ile Ser
    1650                1655                1660                
Gly Phe Glu Asn Phe Glu Lys Lys Ile Asn Tyr Arg Phe Lys Asn Lys
1665                1670                1675                1680
Ala Tyr Leu Leu Gln Ala Phe Thr His Ala Ser Tyr His Tyr Asn Thr
                1685                1690                1695    
Ile Thr Asp Cys Tyr Gln Arg Leu Glu Phe Leu Gly Asp Ala Ile Leu
            1700                1705                1710        
Asp Tyr Leu Ile Thr Lys His Leu Tyr Glu Asp Pro Arg Gln His Ser
        1715                1720                1725            
Pro Gly Val Leu Thr Asp Leu Arg Ser Ala Leu Val Asn Asn Thr Ile
    1730                1735                1740                
Phe Ala Ser Leu Ala Val Lys Tyr Asp Tyr His Lys Tyr Phe Lys Ala
1745                1750                1755                1760
Val Ser Pro Glu Leu Phe His Val Ile Asp Asp Phe Val Gln Phe Gln
                1765                1770                1775    
Leu Glu Lys Asn Glu Met Gln Gly Met Asp Ser Glu Leu Arg Arg Ser
            1780                1785                1790        
Glu Glu Asp Glu Glu Lys Glu Glu Asp Ile Glu Val Pro Lys Ala Met
        1795                1800                1805            
Gly Asp Ile Phe Glu Ser Leu Ala Gly Ala Ile Tyr Met Asp Ser Gly
    1810                1815                1820                
Met Ser Leu Glu Thr Val Trp Gln Val Tyr Tyr Pro Met Met Arg Pro
1825                1830                1835                1840
Leu Ile Glu Lys Phe Ser Ala Asn Val Pro Arg Ser Pro Val Arg Glu
                1845                1850                1855    
Leu Leu Glu Met Glu Pro Glu Thr Ala Lys Phe Ser Pro Ala Glu Arg
            1860                1865                1870        
Thr Tyr Asp Gly Lys Val Arg Val Thr Val Glu Val Val Gly Lys Gly
        1875                1880                1885            
Lys Phe Lys Gly Val Gly Arg Ser Tyr Arg Ile Ala Lys Ser Ala Ala
    1890                1895                1900                
Ala Arg Arg Ala Leu Arg Ser Leu Lys Ala Asn Gln Pro Gln Val Pro
1905                1910                1915                1920
Asn Ser
        


<210> 2
<211> 604
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 2
Met Lys Ser Pro Ala Leu Gln Pro Leu Ser Met Ala Gly Leu Gln Leu
 1               5                  10                  15      
Met Thr Pro Ala Ser Ser Pro Met Gly Pro Phe Phe Gly Leu Pro Trp
            20                  25                  30          
Gln Gln Glu Ala Ile His Asp Asn Ile Tyr Thr Pro Arg Lys Tyr Gln
        35                  40                  45              
Val Glu Leu Leu Glu Ala Ala Leu Asp His Asn Thr Ile Val Cys Leu
    50                  55                  60                  
Asn Thr Gly Ser Gly Lys Thr Phe Ile Ala Val Leu Leu Thr Lys Glu
65                  70                  75                  80  
Leu Ser Tyr Gln Ile Arg Gly Asp Phe Ser Arg Asn Gly Lys Arg Thr
                85                  90                  95      
Val Phe Leu Val Asn Ser Ala Asn Gln Val Ala Gln Gln Val Ser Ala
            100                 105                 110         
Val Arg Thr His Ser Asp Leu Lys Val Gly Glu Tyr Ser Asn Leu Glu
        115                 120                 125             
Val Asn Ala Ser Trp Thr Lys Glu Arg Trp Asn Gln Glu Phe Thr Lys
    130                 135                 140                 
His Gln Val Leu Ile Met Thr Cys Tyr Val Ala Leu Asn Val Leu Lys
145                 150                 155                 160 
Asn Gly Tyr Leu Ser Leu Ser Asp Ile Asn Leu Leu Val Phe Asp Glu
                165                 170                 175     
Cys His Leu Ala Ile Leu Asp His Pro Tyr Arg Glu Ile Met Lys Leu
            180                 185                 190         
Cys Glu Asn Cys Pro Ser Cys Pro Arg Ile Leu Gly Leu Thr Ala Ser
        195                 200                 205             
Ile Leu Asn Gly Lys Cys Asp Pro Glu Glu Leu Glu Glu Lys Ile Gln
    210                 215                 220                 
Lys Leu Glu Lys Ile Leu Lys Ser Asn Ala Glu Thr Ala Thr Asp Leu
225                 230                 235                 240 
Val Val Leu Asp Arg Tyr Thr Ser Gln Pro Cys Glu Ile Val Val Asp
                245                 250                 255     
Cys Gly Pro Phe Thr Asp Arg Ser Gly Leu Tyr Glu Arg Leu Leu Met
            260                 265                 270         
Glu Leu Glu Glu Ala Leu Asn Phe Ile Asn Asp Cys Asn Ile Ser Val
        275                 280                 285             
His Ser Lys Glu Arg Asp Ser Thr Leu Ile Ser Lys Gln Ile Leu Ser
    290                 295                 300                 
Asp Cys Arg Ala Val Leu Val Val Leu Gly Pro Trp Cys Ala Asp Lys
305                 310                 315                 320 
Val Ala Gly Met Met Val Arg Glu Leu Gln Lys Tyr Ile Lys His Glu
                325                 330                 335     
Gln Glu Glu Leu His Arg Lys Phe Leu Leu Phe Thr Asp Thr Phe Leu
            340                 345                 350         
Arg Lys Ile His Ala Leu Cys Glu Glu His Phe Ser Pro Ala Ser Leu
        355                 360                 365             
Asp Leu Lys Phe Val Thr Pro Lys Val Ile Lys Leu Leu Glu Ile Leu
    370                 375                 380                 
Arg Lys Tyr Lys Pro Tyr Glu Arg Gln Gln Phe Glu Ser Val Glu Trp
385                 390                 395                 400 
Tyr Asn Asn Arg Asn Gln Asp Asn Tyr Val Ser Trp Ser Asp Ser Glu
                405                 410                 415     
Asp Asp Asp Glu Asp Glu Glu Ile Glu Glu Lys Glu Lys Pro Glu Thr
            420                 425                 430         
Asn Phe Pro Ser Pro Phe Thr Asn Ile Leu Cys Gly Ile Ile Phe Val
        435                 440                 445             
Glu Arg Arg Tyr Thr Ala Val Val Leu Asn Arg Leu Ile Lys Glu Ala
    450                 455                 460                 
Gly Lys Gln Asp Pro Glu Leu Ala Tyr Ile Ser Ser Asn Phe Ile Thr
465                 470                 475                 480 
Gly His Gly Ile Gly Lys Asn Gln Pro Arg Asn Lys Gln Met Glu Ala
                485                 490                 495     
Glu Phe Arg Lys Gln Glu Glu Val Leu Arg Lys Phe Arg Ala His Glu
            500                 505                 510         
Thr Asn Leu Leu Ile Ala Thr Ser Ile Val Glu Glu Gly Val Asp Ile
        515                 520                 525             
Pro Lys Cys Asn Leu Val Val Arg Phe Asp Leu Pro Thr Glu Tyr Arg
    530                 535                 540                 
Ser Tyr Val Gln Ser Lys Gly Arg Ala Arg Ala Pro Ile Ser Asn Tyr
545                 550                 555                 560 
Ile Met Leu Ala Asp Thr Asp Lys Ile Lys Ser Phe Glu Glu Asp Leu
                565                 570                 575     
Lys Thr Tyr Lys Ala Ile Glu Lys Ile Leu Arg Asn Lys Cys Ser Lys
            580                 585                 590         
Ser Val Asp Thr Gly Glu Thr Asp Ile Asp Pro Val
        595                 600                 


<210> 3
<211> 1318
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 3
Met Asp Asp Asp Asp Val Phe Pro Pro Tyr Val Leu Arg Pro Asp Asp
 1               5                  10                  15      
Gly Gly Pro Arg Val Thr Ile Asn Thr Ala Ile Gly His Ile Asn Arg
            20                  25                  30          
Tyr Cys Ala Arg Leu Pro Ser Asp Pro Phe Thr His Leu Ala Pro Lys
        35                  40                  45              
Cys Arg Thr Arg Glu Leu Pro Asp Gly Thr Phe Tyr Ser Thr Leu Tyr
    50                  55                  60                  
Leu Pro Ile Asn Ser Pro Leu Arg Ala Ser Ile Val Gly Pro Pro Met
65                  70                  75                  80  
Ser Cys Val Arg Leu Ala Glu Arg Val Val Ala Leu Ile Cys Cys Glu
                85                  90                  95      
Lys Leu His Lys Ile Gly Glu Leu Asp Asp His Leu Met Pro Val Gly
            100                 105                 110         
Lys Glu Thr Val Lys Tyr Glu Glu Glu Leu Asp Leu His Asp Glu Glu
        115                 120                 125             
Glu Thr Ser Val Pro Gly Arg Pro Gly Ser Thr Lys Arg Arg Gln Cys
    130                 135                 140                 
Tyr Pro Lys Ala Ile Pro Glu Cys Leu Arg Asp Ser Tyr Pro Arg Pro
145                 150                 155                 160 
Asp Gln Pro Cys Tyr Leu Tyr Val Ile Gly Met Val Leu Thr Thr Pro
                165                 170                 175     
Leu Pro Asp Glu Leu Asn Phe Arg Arg Arg Lys Leu Tyr Pro Pro Glu
            180                 185                 190         
Asp Thr Thr Arg Cys Phe Gly Ile Leu Thr Ala Lys Pro Ile Pro Gln
        195                 200                 205             
Ile Pro His Phe Pro Val Tyr Thr Arg Ser Gly Glu Val Thr Ile Ser
    210                 215                 220                 
Ile Glu Leu Lys Lys Ser Gly Phe Met Leu Ser Leu Gln Met Leu Glu
225                 230                 235                 240 
Leu Ile Thr Arg Leu His Gln Tyr Ile Phe Ser His Ile Leu Arg Leu
                245                 250                 255     
Glu Lys Pro Ala Leu Glu Phe Lys Pro Thr Asp Ala Asp Ser Ala Tyr
            260                 265                 270         
Cys Val Leu Pro Leu Asn Val Val Asn Asp Ser Ser Thr Leu Asp Ile
        275                 280                 285             
Asp Phe Lys Phe Met Glu Asp Ile Glu Lys Ser Glu Ala Arg Ile Gly
    290                 295                 300                 
Ile Pro Ser Thr Lys Tyr Thr Lys Glu Thr Pro Phe Val Phe Lys Leu
305                 310                 315                 320 
Glu Asp Tyr Gln Asp Ala Val Ile Ile Pro Arg Tyr Arg Asn Phe Asp
                325                 330                 335     
Gln Pro His Arg Phe Tyr Val Ala Asp Val Tyr Thr Asp Leu Thr Pro
            340                 345                 350         
Leu Ser Lys Phe Pro Ser Pro Glu Tyr Glu Thr Phe Ala Glu Tyr Tyr
        355                 360                 365             
Lys Thr Lys Tyr Asn Leu Asp Leu Thr Asn Leu Asn Gln Pro Leu Leu
    370                 375                 380                 
Asp Val Asp His Thr Ser Ser Arg Leu Asn Leu Leu Thr Pro Arg His
385                 390                 395                 400 
Leu Asn Gln Lys Gly Lys Ala Leu Pro Leu Ser Ser Ala Glu Lys Arg
                405                 410                 415     
Lys Ala Lys Trp Glu Ser Leu Gln Asn Lys Gln Ile Leu Val Pro Glu
            420                 425                 430         
Leu Cys Ala Ile His Pro Ile Pro Ala Ser Leu Trp Arg Lys Ala Val
        435                 440                 445             
Cys Leu Pro Ser Ile Leu Tyr Arg Leu His Cys Leu Leu Thr Ala Glu
    450                 455                 460                 
Glu Leu Arg Ala Gln Thr Ala Ser Asp Ala Gly Val Gly Val Arg Ser
465                 470                 475                 480 
Leu Pro Ala Asp Phe Arg Tyr Pro Asn Leu Asp Phe Gly Trp Lys Lys
                485                 490                 495     
Ser Ile Asp Ser Lys Ser Phe Ile Ser Ile Ser Asn Ser Ser Ser Ala
            500                 505                 510         
Glu Asn Asp Asn Tyr Cys Lys His Ser Thr Ile Val Pro Glu Asn Ala
        515                 520                 525             
Ala His Gln Gly Ala Asn Arg Thr Ser Ser Leu Glu Asn His Asp Gln
    530                 535                 540                 
Met Ser Val Asn Cys Arg Thr Leu Leu Ser Glu Ser Pro Gly Lys Leu
545                 550                 555                 560 
His Val Glu Val Ser Ala Asp Leu Thr Ala Ile Asn Gly Leu Ser Tyr
                565                 570                 575     
Asn Gln Asn Leu Ala Asn Gly Ser Tyr Asp Leu Ala Asn Arg Asp Phe
            580                 585                 590         
Cys Gln Gly Asn Gln Leu Asn Tyr Tyr Lys Gln Glu Ile Pro Val Gln
        595                 600                 605             
Pro Thr Thr Ser Tyr Ser Ile Gln Asn Leu Tyr Ser Tyr Glu Asn Gln
    610                 615                 620                 
Pro Gln Pro Ser Asp Glu Cys Thr Leu Leu Ser Asn Lys Tyr Leu Asp
625                 630                 635                 640 
Gly Asn Ala Asn Lys Ser Thr Ser Asp Gly Ser Pro Val Met Ala Val
                645                 650                 655     
Met Pro Gly Thr Thr Asp Thr Ile Gln Val Leu Lys Gly Arg Met Asp
            660                 665                 670         
Ser Glu Gln Ser Pro Ser Ile Gly Tyr Ser Ser Arg Thr Leu Gly Pro
        675                 680                 685             
Asn Pro Gly Leu Ile Leu Gln Ala Leu Thr Leu Ser Asn Ala Ser Asp
    690                 695                 700                 
Gly Phe Asn Leu Glu Arg Leu Glu Met Leu Gly Asp Ser Phe Leu Lys
705                 710                 715                 720 
His Ala Ile Thr Thr Tyr Leu Phe Cys Thr Tyr Pro Asp Ala His Glu
                725                 730                 735     
Gly Arg Leu Ser Tyr Met Arg Ser Lys Lys Val Ser Asn Cys Asn Leu
            740                 745                 750         
Tyr Arg Leu Gly Lys Lys Lys Gly Leu Pro Ser Arg Met Val Val Ser
        755                 760                 765             
Ile Phe Asp Pro Pro Val Asn Trp Leu Pro Pro Gly Tyr Val Val Asn
    770                 775                 780                 
Gln Asp Lys Ser Asn Thr Asp Lys Trp Glu Lys Asp Glu Met Thr Lys
785                 790                 795                 800 
Asp Cys Met Leu Ala Asn Gly Lys Leu Asp Glu Asp Tyr Glu Glu Glu
                805                 810                 815     
Asp Glu Glu Glu Glu Ser Leu Met Trp Arg Ala Pro Lys Glu Glu Ala
            820                 825                 830         
Asp Tyr Glu Asp Asp Phe Leu Glu Tyr Asp Gln Glu His Ile Arg Phe
        835                 840                 845             
Ile Asp Asn Met Leu Met Gly Ser Gly Ala Phe Val Lys Lys Ile Ser
    850                 855                 860                 
Leu Ser Pro Phe Ser Thr Thr Asp Ser Ala Tyr Glu Trp Lys Met Pro
865                 870                 875                 880 
Lys Lys Ser Ser Leu Gly Ser Met Pro Phe Ser Ser Asp Phe Glu Asp
                885                 890                 895     
Phe Asp Tyr Ser Ser Trp Asp Ala Met Cys Tyr Leu Asp Pro Ser Lys
            900                 905                 910         
Ala Val Glu Glu Asp Asp Phe Val Val Gly Phe Trp Asn Pro Ser Glu
        915                 920                 925             
Glu Asn Cys Gly Val Asp Thr Gly Lys Gln Ser Ile Ser Tyr Asp Leu
    930                 935                 940                 
His Thr Glu Gln Cys Ile Ala Asp Lys Ser Ile Ala Asp Cys Val Glu
945                 950                 955                 960 
Ala Leu Leu Gly Cys Tyr Leu Thr Ser Cys Gly Glu Arg Ala Ala Gln
                965                 970                 975     
Leu Phe Leu Cys Ser Leu Gly Leu Lys Val Leu Pro Val Ile Lys Arg
            980                 985                 990         
Thr Asp Arg Glu Lys Ala Leu Cys Pro Thr Arg Glu Asn Phe Asn Ser
        995                 1000                1005            
Gln Gln Lys Asn Leu Ser Val Ser Cys Ala Ala Ala Ser Val Ala Ser
    1010                1015                1020                
Ser Arg Ser Ser Val Leu Lys Asp Ser Glu Tyr Gly Cys Leu Lys Ile
1025                1030                1035                1040
Pro Pro Arg Cys Met Phe Asp His Pro Asp Ala Asp Lys Thr Leu Asn
                1045                1050                1055    
His Leu Ile Ser Gly Phe Glu Asn Phe Glu Lys Lys Ile Asn Tyr Arg
            1060                1065                1070        
Phe Lys Asn Lys Ala Tyr Leu Leu Gln Ala Phe Thr His Ala Ser Tyr
        1075                1080                1085            
His Tyr Asn Thr Ile Thr Asp Cys Tyr Gln Arg Leu Glu Phe Leu Gly
    1090                1095                1100                
Asp Ala Ile Leu Asp Tyr Leu Ile Thr Lys His Leu Tyr Glu Asp Pro
1105                1110                1115                1120
Arg Gln His Ser Pro Gly Val Leu Thr Asp Leu Arg Ser Ala Leu Val
                1125                1130                1135    
Asn Asn Thr Ile Phe Ala Ser Leu Ala Val Lys Tyr Asp Tyr His Lys
            1140                1145                1150        
Tyr Phe Lys Ala Val Ser Pro Glu Leu Phe His Val Ile Asp Asp Phe
        1155                1160                1165            
Val Gln Phe Gln Leu Glu Lys Asn Glu Met Gln Gly Met Asp Ser Glu
    1170                1175                1180                
Leu Arg Arg Ser Glu Glu Asp Glu Glu Lys Glu Glu Asp Ile Glu Val
1185                1190                1195                1200
Pro Lys Ala Met Gly Asp Ile Phe Glu Ser Leu Ala Gly Ala Ile Tyr
                1205                1210                1215    
Met Asp Ser Gly Met Ser Leu Glu Thr Val Trp Gln Val Tyr Tyr Pro
            1220                1225                1230        
Met Met Arg Pro Leu Ile Glu Lys Phe Ser Ala Asn Val Pro Arg Ser
        1235                1240                1245            
Pro Val Arg Glu Leu Leu Glu Met Glu Pro Glu Thr Ala Lys Phe Ser
    1250                1255                1260                
Pro Ala Glu Arg Thr Tyr Asp Gly Lys Val Arg Val Thr Val Glu Val
1265                1270                1275                1280
Val Gly Lys Gly Lys Phe Lys Gly Val Gly Arg Ser Tyr Arg Ile Ala
                1285                1290                1295    
Lys Ser Ala Ala Ala Arg Arg Ala Leu Arg Ser Leu Lys Ala Asn Gln
            1300                1305                1310        
Pro Gln Val Pro Asn Ser
        1315            


<210> 4
<211> 1922
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 4
Met Lys Ser Pro Ala Leu Gln Pro Leu Ser Met Ala Gly Leu Gln Leu
 1               5                  10                  15      
Met Thr Pro Ala Ser Ser Pro Met Gly Pro Phe Phe Gly Leu Pro Trp
            20                  25                  30          
Gln Gln Glu Ala Ile His Asp Asn Ile Tyr Thr Pro Arg Lys Tyr Gln
        35                  40                  45              
Val Glu Leu Leu Glu Ala Ala Leu Asp His Asn Thr Ile Val Cys Leu
    50                  55                  60                  
Asn Thr Gly Ser Gly Ala Thr Phe Ile Ala Val Leu Leu Thr Lys Glu
65                  70                  75                  80  
Leu Ser Tyr Gln Ile Arg Gly Asp Phe Ser Arg Asn Gly Lys Arg Thr
                85                  90                  95      
Val Phe Leu Val Asn Ser Ala Asn Gln Val Ala Gln Gln Val Ser Ala
            100                 105                 110         
Val Arg Thr His Ser Asp Leu Lys Val Gly Glu Tyr Ser Asn Leu Glu
        115                 120                 125             
Val Asn Ala Ser Trp Thr Lys Glu Arg Trp Asn Gln Glu Phe Thr Lys
    130                 135                 140                 
His Gln Val Leu Ile Met Thr Cys Tyr Val Ala Leu Asn Val Leu Lys
145                 150                 155                 160 
Asn Gly Tyr Leu Ser Leu Ser Asp Ile Asn Leu Leu Val Phe Asp Glu
                165                 170                 175     
Cys His Leu Ala Ile Leu Asp His Pro Tyr Arg Glu Ile Met Lys Leu
            180                 185                 190         
Cys Glu Asn Cys Pro Ser Cys Pro Arg Ile Leu Gly Leu Thr Ala Ser
        195                 200                 205             
Ile Leu Asn Gly Lys Cys Asp Pro Glu Glu Leu Glu Glu Lys Ile Gln
    210                 215                 220                 
Lys Leu Glu Lys Ile Leu Lys Ser Asn Ala Glu Thr Ala Thr Asp Leu
225                 230                 235                 240 
Val Val Leu Asp Arg Tyr Thr Ser Gln Pro Cys Glu Ile Val Val Asp
                245                 250                 255     
Cys Gly Pro Phe Thr Asp Arg Ser Gly Leu Tyr Glu Arg Leu Leu Met
            260                 265                 270         
Glu Leu Glu Glu Ala Leu Asn Phe Ile Asn Asp Cys Asn Ile Ser Val
        275                 280                 285             
His Ser Lys Glu Arg Asp Ser Thr Leu Ile Ser Lys Gln Ile Leu Ser
    290                 295                 300                 
Asp Cys Arg Ala Val Leu Val Val Leu Gly Pro Trp Cys Ala Asp Lys
305                 310                 315                 320 
Val Ala Gly Met Met Val Arg Glu Leu Gln Lys Tyr Ile Lys His Glu
                325                 330                 335     
Gln Glu Glu Leu His Arg Lys Phe Leu Leu Phe Thr Asp Thr Phe Leu
            340                 345                 350         
Arg Lys Ile His Ala Leu Cys Glu Glu His Phe Ser Pro Ala Ser Leu
        355                 360                 365             
Asp Leu Lys Phe Val Thr Pro Lys Val Ile Lys Leu Leu Glu Ile Leu
    370                 375                 380                 
Arg Lys Tyr Lys Pro Tyr Glu Arg Gln Gln Phe Glu Ser Val Glu Trp
385                 390                 395                 400 
Tyr Asn Asn Arg Asn Gln Asp Asn Tyr Val Ser Trp Ser Asp Ser Glu
                405                 410                 415     
Asp Asp Asp Glu Asp Glu Glu Ile Glu Glu Lys Glu Lys Pro Glu Thr
            420                 425                 430         
Asn Phe Pro Ser Pro Phe Thr Asn Ile Leu Cys Gly Ile Ile Phe Val
        435                 440                 445             
Glu Arg Arg Tyr Thr Ala Val Val Leu Asn Arg Leu Ile Lys Glu Ala
    450                 455                 460                 
Gly Lys Gln Asp Pro Glu Leu Ala Tyr Ile Ser Ser Asn Phe Ile Thr
465                 470                 475                 480 
Gly His Gly Ile Gly Lys Asn Gln Pro Arg Asn Lys Gln Met Glu Ala
                485                 490                 495     
Glu Phe Arg Lys Gln Glu Glu Val Leu Arg Lys Phe Arg Ala His Glu
            500                 505                 510         
Thr Asn Leu Leu Ile Ala Thr Ser Ile Val Glu Glu Gly Val Asp Ile
        515                 520                 525             
Pro Lys Cys Asn Leu Val Val Arg Phe Asp Leu Pro Thr Glu Tyr Arg
    530                 535                 540                 
Ser Tyr Val Gln Ser Lys Gly Arg Ala Arg Ala Pro Ile Ser Asn Tyr
545                 550                 555                 560 
Ile Met Leu Ala Asp Thr Asp Lys Ile Lys Ser Phe Glu Glu Asp Leu
                565                 570                 575     
Lys Thr Tyr Lys Ala Ile Glu Lys Ile Leu Arg Asn Lys Cys Ser Lys
            580                 585                 590         
Ser Val Asp Thr Gly Glu Thr Asp Ile Asp Pro Val Met Asp Asp Asp
        595                 600                 605             
Asp Val Phe Pro Pro Tyr Val Leu Arg Pro Asp Asp Gly Gly Pro Arg
    610                 615                 620                 
Val Thr Ile Asn Thr Ala Ile Gly His Ile Asn Arg Tyr Cys Ala Arg
625                 630                 635                 640 
Leu Pro Ser Asp Pro Phe Thr His Leu Ala Pro Lys Cys Arg Thr Arg
                645                 650                 655     
Glu Leu Pro Asp Gly Thr Phe Tyr Ser Thr Leu Tyr Leu Pro Ile Asn
            660                 665                 670         
Ser Pro Leu Arg Ala Ser Ile Val Gly Pro Pro Met Ser Cys Val Arg
        675                 680                 685             
Leu Ala Glu Arg Val Val Ala Leu Ile Cys Cys Glu Lys Leu His Lys
    690                 695                 700                 
Ile Gly Glu Leu Asp Asp His Leu Met Pro Val Gly Lys Glu Thr Val
705                 710                 715                 720 
Lys Tyr Glu Glu Glu Leu Asp Leu His Asp Glu Glu Glu Thr Ser Val
                725                 730                 735     
Pro Gly Arg Pro Gly Ser Thr Lys Arg Arg Gln Cys Tyr Pro Lys Ala
            740                 745                 750         
Ile Pro Glu Cys Leu Arg Asp Ser Tyr Pro Arg Pro Asp Gln Pro Cys
        755                 760                 765             
Tyr Leu Tyr Val Ile Gly Met Val Leu Thr Thr Pro Leu Pro Asp Glu
    770                 775                 780                 
Leu Asn Phe Arg Arg Arg Lys Leu Tyr Pro Pro Glu Asp Thr Thr Arg
785                 790                 795                 800 
Cys Phe Gly Ile Leu Thr Ala Lys Pro Ile Pro Gln Ile Pro His Phe
                805                 810                 815     
Pro Val Tyr Thr Arg Ser Gly Glu Val Thr Ile Ser Ile Glu Leu Lys
            820                 825                 830         
Lys Ser Gly Phe Met Leu Ser Leu Gln Met Leu Glu Leu Ile Thr Arg
        835                 840                 845             
Leu His Gln Tyr Ile Phe Ser His Ile Leu Arg Leu Glu Lys Pro Ala
    850                 855                 860                 
Leu Glu Phe Lys Pro Thr Asp Ala Asp Ser Ala Tyr Cys Val Leu Pro
865                 870                 875                 880 
Leu Asn Val Val Asn Asp Ser Ser Thr Leu Asp Ile Asp Phe Lys Phe
                885                 890                 895     
Met Glu Asp Ile Glu Lys Ser Glu Ala Arg Ile Gly Ile Pro Ser Thr
            900                 905                 910         
Lys Tyr Thr Lys Glu Thr Pro Phe Val Phe Lys Leu Glu Asp Tyr Gln
        915                 920                 925             
Asp Ala Val Ile Ile Pro Arg Tyr Arg Asn Phe Asp Gln Pro His Arg
    930                 935                 940                 
Phe Tyr Val Ala Asp Val Tyr Thr Asp Leu Thr Pro Leu Ser Lys Phe
945                 950                 955                 960 
Pro Ser Pro Glu Tyr Glu Thr Phe Ala Glu Tyr Tyr Lys Thr Lys Tyr
                965                 970                 975     
Asn Leu Asp Leu Thr Asn Leu Asn Gln Pro Leu Leu Asp Val Asp His
            980                 985                 990         
Thr Ser Ser Arg Leu Asn Leu Leu Thr Pro Arg His Leu Asn Gln Lys
        995                 1000                1005            
Gly Lys Ala Leu Pro Leu Ser Ser Ala Glu Lys Arg Lys Ala Lys Trp
    1010                1015                1020                
Glu Ser Leu Gln Asn Lys Gln Ile Leu Val Pro Glu Leu Cys Ala Ile
1025                1030                1035                1040
His Pro Ile Pro Ala Ser Leu Trp Arg Lys Ala Val Cys Leu Pro Ser
                1045                1050                1055    
Ile Leu Tyr Arg Leu His Cys Leu Leu Thr Ala Glu Glu Leu Arg Ala
            1060                1065                1070        
Gln Thr Ala Ser Asp Ala Gly Val Gly Val Arg Ser Leu Pro Ala Asp
        1075                1080                1085            
Phe Arg Tyr Pro Asn Leu Asp Phe Gly Trp Lys Lys Ser Ile Asp Ser
    1090                1095                1100                
Lys Ser Phe Ile Ser Ile Ser Asn Ser Ser Ser Ala Glu Asn Asp Asn
1105                1110                1115                1120
Tyr Cys Lys His Ser Thr Ile Val Pro Glu Asn Ala Ala His Gln Gly
                1125                1130                1135    
Ala Asn Arg Thr Ser Ser Leu Glu Asn His Asp Gln Met Ser Val Asn
            1140                1145                1150        
Cys Arg Thr Leu Leu Ser Glu Ser Pro Gly Lys Leu His Val Glu Val
        1155                1160                1165            
Ser Ala Asp Leu Thr Ala Ile Asn Gly Leu Ser Tyr Asn Gln Asn Leu
    1170                1175                1180                
Ala Asn Gly Ser Tyr Asp Leu Ala Asn Arg Asp Phe Cys Gln Gly Asn
1185                1190                1195                1200
Gln Leu Asn Tyr Tyr Lys Gln Glu Ile Pro Val Gln Pro Thr Thr Ser
                1205                1210                1215    
Tyr Ser Ile Gln Asn Leu Tyr Ser Tyr Glu Asn Gln Pro Gln Pro Ser
            1220                1225                1230        
Asp Glu Cys Thr Leu Leu Ser Asn Lys Tyr Leu Asp Gly Asn Ala Asn
        1235                1240                1245            
Lys Ser Thr Ser Asp Gly Ser Pro Val Met Ala Val Met Pro Gly Thr
    1250                1255                1260                
Thr Asp Thr Ile Gln Val Leu Lys Gly Arg Met Asp Ser Glu Gln Ser
1265                1270                1275                1280
Pro Ser Ile Gly Tyr Ser Ser Arg Thr Leu Gly Pro Asn Pro Gly Leu
                1285                1290                1295    
Ile Leu Gln Ala Leu Thr Leu Ser Asn Ala Ser Asp Gly Phe Asn Leu
            1300                1305                1310        
Glu Arg Leu Glu Met Leu Gly Asp Ser Phe Leu Lys His Ala Ile Thr
        1315                1320                1325            
Thr Tyr Leu Phe Cys Thr Tyr Pro Asp Ala His Glu Gly Arg Leu Ser
    1330                1335                1340                
Tyr Met Arg Ser Lys Lys Val Ser Asn Cys Asn Leu Tyr Arg Leu Gly
1345                1350                1355                1360
Lys Lys Lys Gly Leu Pro Ser Arg Met Val Val Ser Ile Phe Asp Pro
                1365                1370                1375    
Pro Val Asn Trp Leu Pro Pro Gly Tyr Val Val Asn Gln Asp Lys Ser
            1380                1385                1390        
Asn Thr Asp Lys Trp Glu Lys Asp Glu Met Thr Lys Asp Cys Met Leu
        1395                1400                1405            
Ala Asn Gly Lys Leu Asp Glu Asp Tyr Glu Glu Glu Asp Glu Glu Glu
    1410                1415                1420                
Glu Ser Leu Met Trp Arg Ala Pro Lys Glu Glu Ala Asp Tyr Glu Asp
1425                1430                1435                1440
Asp Phe Leu Glu Tyr Asp Gln Glu His Ile Arg Phe Ile Asp Asn Met
                1445                1450                1455    
Leu Met Gly Ser Gly Ala Phe Val Lys Lys Ile Ser Leu Ser Pro Phe
            1460                1465                1470        
Ser Thr Thr Asp Ser Ala Tyr Glu Trp Lys Met Pro Lys Lys Ser Ser
        1475                1480                1485            
Leu Gly Ser Met Pro Phe Ser Ser Asp Phe Glu Asp Phe Asp Tyr Ser
    1490                1495                1500                
Ser Trp Asp Ala Met Cys Tyr Leu Asp Pro Ser Lys Ala Val Glu Glu
1505                1510                1515                1520
Asp Asp Phe Val Val Gly Phe Trp Asn Pro Ser Glu Glu Asn Cys Gly
                1525                1530                1535    
Val Asp Thr Gly Lys Gln Ser Ile Ser Tyr Asp Leu His Thr Glu Gln
            1540                1545                1550        
Cys Ile Ala Asp Lys Ser Ile Ala Asp Cys Val Glu Ala Leu Leu Gly
        1555                1560                1565            
Cys Tyr Leu Thr Ser Cys Gly Glu Arg Ala Ala Gln Leu Phe Leu Cys
    1570                1575                1580                
Ser Leu Gly Leu Lys Val Leu Pro Val Ile Lys Arg Thr Asp Arg Glu
1585                1590                1595                1600
Lys Ala Leu Cys Pro Thr Arg Glu Asn Phe Asn Ser Gln Gln Lys Asn
                1605                1610                1615    
Leu Ser Val Ser Cys Ala Ala Ala Ser Val Ala Ser Ser Arg Ser Ser
            1620                1625                1630        
Val Leu Lys Asp Ser Glu Tyr Gly Cys Leu Lys Ile Pro Pro Arg Cys
        1635                1640                1645            
Met Phe Asp His Pro Asp Ala Asp Lys Thr Leu Asn His Leu Ile Ser
    1650                1655                1660                
Gly Phe Glu Asn Phe Glu Lys Lys Ile Asn Tyr Arg Phe Lys Asn Lys
1665                1670                1675                1680
Ala Tyr Leu Leu Gln Ala Phe Thr His Ala Ser Tyr His Tyr Asn Thr
                1685                1690                1695    
Ile Thr Asp Cys Tyr Gln Arg Leu Glu Phe Leu Gly Asp Ala Ile Leu
            1700                1705                1710        
Asp Tyr Leu Ile Thr Lys His Leu Tyr Glu Asp Pro Arg Gln His Ser
        1715                1720                1725            
Pro Gly Val Leu Thr Asp Leu Arg Ser Ala Leu Val Asn Asn Thr Ile
    1730                1735                1740                
Phe Ala Ser Leu Ala Val Lys Tyr Asp Tyr His Lys Tyr Phe Lys Ala
1745                1750                1755                1760
Val Ser Pro Glu Leu Phe His Val Ile Asp Asp Phe Val Gln Phe Gln
                1765                1770                1775    
Leu Glu Lys Asn Glu Met Gln Gly Met Asp Ser Glu Leu Arg Arg Ser
            1780                1785                1790        
Glu Glu Asp Glu Glu Lys Glu Glu Asp Ile Glu Val Pro Lys Ala Met
        1795                1800                1805            
Gly Asp Ile Phe Glu Ser Leu Ala Gly Ala Ile Tyr Met Asp Ser Gly
    1810                1815                1820                
Met Ser Leu Glu Thr Val Trp Gln Val Tyr Tyr Pro Met Met Arg Pro
1825                1830                1835                1840
Leu Ile Glu Lys Phe Ser Ala Asn Val Pro Arg Ser Pro Val Arg Glu
                1845                1850                1855    
Leu Leu Glu Met Glu Pro Glu Thr Ala Lys Phe Ser Pro Ala Glu Arg
            1860                1865                1870        
Thr Tyr Asp Gly Lys Val Arg Val Thr Val Glu Val Val Gly Lys Gly
        1875                1880                1885            
Lys Phe Lys Gly Val Gly Arg Ser Tyr Arg Ile Ala Lys Ser Ala Ala
    1890                1895                1900                
Ala Arg Arg Ala Leu Arg Ser Leu Lys Ala Asn Gln Pro Gln Val Pro
1905                1910                1915                1920
Asn Ser
        


<210> 5
<211> 37
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic polynucleotide

<400> 5
ugagguagua gguuguauag uuugaaaguu cacgauu                          37

<210> 6
<211> 37
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic polynucleotide

<400> 6
ucgugaacuu ucaaacuaua caaccuacua ccucauu                          37

<210> 7
<211> 73
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic polynucleotide

<400> 7
ugagguagua gguuguauag uuuuaggguc acacccacca cugggagaua acuauacaau 60
cuacugucuu acc                                                    73

<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 8
Cys Leu Asn Thr Gly Ser Gly Lys Thr
 1               5                  


<210> 9
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 9
Cys Leu Asn Asp Gly Ser Gly Lys Thr
 1               5                  


<210> 10
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 10
Cys Leu Asn Thr Pro Ser Gly Lys Thr
 1               5                  


<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 11
Cys Leu Ser Thr Gly Ser Gly Lys Thr
 1               5                  


<210> 12
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic primer

<400> 12
gggggcgcca tgaaaagccc tgctttgcaa cccctcagca tggcag                46

<210> 13
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic primer

<400> 13
cccctcgagt cagctattgg gaacctgagg ttgattagc                        39

<210> 14
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic primer

<400> 14
gggggcgcca tggatgatga tgacgttttc ccaccatatg tgttg                 45

<210> 15
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic primer

<400> 15
cgagtcacaa tcaacacgga ccatttgatg ccagttggga aagag                 45

<210> 16
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic primer

<400> 16
cccaactggc atcaaatggt ccgtgttgat tgtgactcgt ggacc                 45

<210> 17
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic primer

<400> 17
gaaaagtttt ctgcaaataa tcaacctcag gttcccaata gctg                  44

<210> 18
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic primer

<400> 18
gggaacctga ggttgattat ttgcagaaaa cttttctatt agtggc                46

<210> 19
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic primer

<400> 19
aacactggct caggggcgac atttattgca gtac                             34

<210> 20
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic primer

<400> 20
gtactgcaat aaatgtcgcc cctgagccag tgtt                             34

<210> 21
<211> 1930
<212> PRT
<213> Pan troglodytes

<400> 21
Met Lys Asn Pro Ala Leu Gln Pro Leu Ser Met Ala Gly Leu Gln Leu
 1               5                  10                  15      
Met Thr Pro Ala Ser Ser Pro Met Gly Pro Phe Phe Gly Leu Pro Trp
            20                  25                  30          
Gln Gln Glu Ala Ile His Asp Asn Ile Tyr Thr Pro Arg Lys Tyr Gln
        35                  40                  45              
Val Glu Leu Leu Glu Ala Ala Leu Asp His Asn Thr Ile Val Cys Leu
    50                  55                  60                  
Asn Thr Gly Ser Gly Lys Thr Phe Ile Ala Val Leu Leu Thr Lys Glu
65                  70                  75                  80  
Leu Ser Tyr Gln Ile Arg Gly Asp Phe Ser Arg Asn Gly Lys Arg Thr
                85                  90                  95      
Val Phe Leu Val Asn Ser Ala Asn Gln Val Ala Gln Gln Val Ser Ala
            100                 105                 110         
Val Arg Thr His Ser Asp Leu Lys Val Gly Glu Tyr Ser Asn Leu Glu
        115                 120                 125             
Val Asn Ala Ser Trp Thr Lys Glu Arg Trp Asn Gln Glu Phe Thr Lys
    130                 135                 140                 
His Gln Val Leu Ile Met Thr Cys Tyr Val Ala Leu Asn Val Leu Lys
145                 150                 155                 160 
Asn Gly Tyr Leu Ser Leu Ser Asp Ile Asn Leu Leu Val Phe Asp Glu
                165                 170                 175     
Cys His Leu Ala Ile Leu Asp His Pro Tyr Arg Glu Ile Met Lys Leu
            180                 185                 190         
Cys Glu Asn Cys Pro Ser Cys Pro Arg Ile Leu Gly Leu Thr Ala Ser
        195                 200                 205             
Ile Leu Asn Gly Lys Cys Asp Pro Glu Glu Leu Glu Glu Lys Ile Gln
    210                 215                 220                 
Lys Leu Glu Lys Ile Leu Lys Ser Asn Ala Glu Thr Ala Thr Asp Leu
225                 230                 235                 240 
Val Val Leu Asp Arg Tyr Thr Ser Gln Pro Cys Glu Ile Val Val Asp
                245                 250                 255     
Cys Gly Pro Phe Thr Asp Arg Ser Gly Leu Tyr Glu Arg Leu Leu Met
            260                 265                 270         
Glu Leu Glu Glu Ala Leu Asn Phe Ile Asn Asp Cys Asn Ile Ser Val
        275                 280                 285             
His Ser Lys Glu Arg Asp Ser Thr Leu Ile Ser Lys Gln Ile Leu Ser
    290                 295                 300                 
Asp Cys Arg Ala Val Leu Val Val Leu Gly Pro Trp Cys Ala Asp Lys
305                 310                 315                 320 
Val Ala Gly Met Met Val Arg Glu Leu Gln Lys Tyr Ile Lys His Glu
                325                 330                 335     
Gln Glu Glu Leu His Arg Lys Phe Leu Leu Phe Thr Asp Thr Phe Leu
            340                 345                 350         
Arg Lys Ile His Ala Leu Cys Glu Glu His Phe Ser Pro Ala Ser Leu
        355                 360                 365             
Asp Leu Lys Phe Val Thr Pro Lys Val Ile Lys Leu Leu Glu Ile Leu
    370                 375                 380                 
Arg Lys Tyr Lys Pro Tyr Glu Arg Gln Gln Phe Glu Ser Val Glu Trp
385                 390                 395                 400 
Tyr Asn Asn Arg Asn Gln Asp Asn Tyr Val Ser Trp Ser Asp Ser Glu
                405                 410                 415     
Asp Asp Asp Glu Asp Glu Glu Ile Glu Glu Lys Glu Lys Pro Glu Thr
            420                 425                 430         
Asn Phe Pro Ser Pro Phe Thr Asn Ile Leu Cys Gly Ile Ile Phe Val
        435                 440                 445             
Glu Arg Arg Tyr Thr Ala Val Val Leu Asn Arg Leu Ile Lys Glu Ala
    450                 455                 460                 
Gly Lys Gln Asp Pro Glu Leu Ala Tyr Ile Ser Ser Asn Phe Ile Thr
465                 470                 475                 480 
Gly His Gly Ile Gly Lys Asn Gln Pro Arg Asn Lys Gln Met Glu Ala
                485                 490                 495     
Glu Phe Arg Lys Gln Glu Glu Val Leu Arg Lys Phe Arg Ala His Glu
            500                 505                 510         
Thr Asn Leu Leu Ile Ala Thr Ser Ile Val Glu Glu Gly Val Asp Ile
        515                 520                 525             
Pro Lys Cys Asn Leu Val Val Arg Phe Asp Leu Pro Thr Glu Tyr Arg
    530                 535                 540                 
Ser Tyr Val Gln Ser Lys Gly Arg Ala Arg Ala Pro Ile Ser Asn Tyr
545                 550                 555                 560 
Ile Met Leu Ala Asp Thr Asp Lys Ile Lys Ser Phe Glu Glu Asp Leu
                565                 570                 575     
Lys Thr Tyr Lys Ala Ile Glu Lys Ile Leu Arg Asn Lys Cys Ser Lys
            580                 585                 590         
Ser Val Asp Thr Gly Glu Ile Asp Ile Asp Pro Val Met Asp Asp Asp
        595                 600                 605             
Asp Val Phe Pro Pro Tyr Val Leu Arg Pro Asp Asp Gly Gly Pro Arg
    610                 615                 620                 
Val Thr Ile Asn Thr Ala Ile Gly His Ile Asn Arg Tyr Cys Ala Arg
625                 630                 635                 640 
Leu Pro Ser Asp Pro Phe Thr His Leu Ala Pro Lys Cys Arg Thr Arg
                645                 650                 655     
Glu Leu Pro Asp Gly Thr Phe Tyr Ser Thr Leu Tyr Leu Pro Ile Asn
            660                 665                 670         
Ser Pro Leu Arg Ala Ser Ile Val Gly Pro Pro Met Ser Cys Val Arg
        675                 680                 685             
Leu Ala Glu Arg Val Val Ala Leu Ile Cys Cys Glu Lys Leu His Lys
    690                 695                 700                 
Ile Gly Glu Leu Asp Asp His Leu Met Pro Val Gly Lys Glu Thr Val
705                 710                 715                 720 
Lys Tyr Glu Glu Glu Leu Asp Leu His Asp Glu Glu Glu Thr Ser Val
                725                 730                 735     
Pro Gly Arg Pro Gly Ser Thr Lys Arg Arg Gln Cys Tyr Pro Lys Ala
            740                 745                 750         
Ile Pro Glu Cys Leu Arg Asp Ser Tyr Pro Arg Pro Asp Gln Pro Cys
        755                 760                 765             
Tyr Leu Tyr Val Ile Gly Met Val Leu Thr Thr Pro Leu Pro Asp Glu
    770                 775                 780                 
Leu Asn Phe Arg Arg Arg Lys Leu Tyr Pro Pro Glu Asp Thr Thr Arg
785                 790                 795                 800 
Cys Phe Gly Ile Leu Thr Ala Lys Pro Ile Pro Gln Ile Pro His Phe
                805                 810                 815     
Pro Val Tyr Thr Arg Ser Gly Glu Val Thr Ile Ser Ile Glu Leu Lys
            820                 825                 830         
Lys Ser Gly Phe Met Leu Ser Leu Gln Met Leu Glu Leu Ile Thr Arg
        835                 840                 845             
Leu His Gln Tyr Ile Phe Ser His Ile Leu Arg Leu Glu Lys Pro Ala
    850                 855                 860                 
Leu Glu Phe Lys Pro Thr Asp Ala Asp Ser Ala Tyr Cys Val Leu Pro
865                 870                 875                 880 
Leu Asn Val Val Asn Asp Ser Ser Thr Leu Asp Ile Asp Phe Lys Phe
                885                 890                 895     
Met Glu Asp Ile Glu Lys Ser Glu Ala Arg Ile Gly Ile Pro Ser Thr
            900                 905                 910         
Lys Tyr Thr Lys Glu Thr Pro Phe Val Phe Lys Leu Glu Asp Tyr Gln
        915                 920                 925             
Asp Ala Val Ile Ile Pro Arg Tyr Arg Asn Phe Asp Gln Pro His Arg
    930                 935                 940                 
Phe Tyr Val Ala Asp Val Tyr Thr Asp Leu Thr Pro Leu Ser Lys Phe
945                 950                 955                 960 
Pro Ser Pro Glu Tyr Glu Thr Phe Ala Glu Tyr Tyr Lys Thr Lys Tyr
                965                 970                 975     
Asn Leu Asp Leu Thr Asn Leu Asn Gln Pro Leu Leu Asp Val Asp His
            980                 985                 990         
Thr Ser Ser Arg Leu Asn Leu Leu Thr Pro Arg His Leu Asn Gln Lys
        995                 1000                1005            
Gly Lys Ala Leu Pro Leu Ser Ser Ala Glu Lys Arg Lys Ala Lys Trp
    1010                1015                1020                
Glu Ser Leu Gln Asn Lys Gln Ile Leu Val Pro Glu Leu Cys Ala Ile
1025                1030                1035                1040
His Pro Ile Pro Ala Ser Leu Trp Arg Lys Ala Val Cys Leu Pro Ser
                1045                1050                1055    
Ile Leu Tyr Arg Leu His Cys Leu Leu Thr Ala Glu Glu Leu Arg Ala
            1060                1065                1070        
Gln Thr Ala Ser Asp Ala Gly Val Gly Val Arg Ser Leu Pro Ala Asp
        1075                1080                1085            
Phe Arg Tyr Pro Asn Leu Asp Phe Gly Trp Lys Lys Ser Ile Asp Ser
    1090                1095                1100                
Lys Ser Phe Ile Ser Ile Ser Asn Ser Ser Ser Ala Glu Asn Asp Asn
1105                1110                1115                1120
Tyr Cys Lys His Ser Thr Ile Val Pro Glu Asn Ala Ala His Gln Gly
                1125                1130                1135    
Ala Asn Arg Thr Ser Ser Leu Glu Asn His Asp Gln Met Ser Val Asn
            1140                1145                1150        
Cys Arg Thr Leu Leu Ser Glu Ser Pro Gly Lys Leu His Val Glu Val
        1155                1160                1165            
Ser Ala Asp Leu Thr Ala Ile Asn Gly Leu Ser Tyr Asn Gln Asn Leu
    1170                1175                1180                
Ala Asn Gly Ser Tyr Asp Leu Ala Asn Arg Asp Phe Cys Gln Gly Asn
1185                1190                1195                1200
Gln Leu Asn Tyr Tyr Lys Gln Glu Ile Pro Val Gln Pro Thr Thr Ser
                1205                1210                1215    
Tyr Ser Ile Gln Asn Leu Tyr Ser Tyr Glu Asn Gln Pro Gln Pro Ser
            1220                1225                1230        
Asp Glu Cys Thr Leu Leu Ser Asn Lys Tyr Leu Asp Gly Asn Ala Asn
        1235                1240                1245            
Lys Ser Thr Ser Asp Gly Ser Pro Val Met Ala Val Met Pro Gly Thr
    1250                1255                1260                
Thr Asp Thr Ile Gln Val Leu Lys Gly Arg Met Asp Ser Glu Gln Ser
1265                1270                1275                1280
Pro Ser Ile Gly Tyr Ser Ser Arg Thr Leu Gly Pro Asn Pro Gly Leu
                1285                1290                1295    
Ile Leu Gln Ala Leu Thr Leu Ser Asn Ala Ser Asp Gly Phe Asn Leu
            1300                1305                1310        
Glu Arg Leu Glu Met Leu Gly Asp Ser Phe Leu Lys His Ala Ile Thr
        1315                1320                1325            
Thr Tyr Leu Phe Cys Thr Tyr Pro Asp Ala His Glu Gly Arg Leu Ser
    1330                1335                1340                
Tyr Met Arg Ser Lys Lys Val Ser Asn Cys Asn Leu Tyr Arg Leu Gly
1345                1350                1355                1360
Lys Lys Lys Gly Leu Pro Ser Arg Met Val Val Ser Ile Phe Asp Pro
                1365                1370                1375    
Pro Val Asn Trp Leu Pro Pro Gly Tyr Val Val Asn Gln Asp Lys Ser
            1380                1385                1390        
Asn Thr Asp Lys Trp Glu Lys Asp Glu Met Thr Lys Asp Cys Met Leu
        1395                1400                1405            
Ala Asn Gly Lys Leu Asp Glu Asp Tyr Glu Glu Glu Asp Glu Glu Glu
    1410                1415                1420                
Glu Ser Leu Met Trp Arg Ala Pro Lys Glu Glu Ala Asp Tyr Glu Asp
1425                1430                1435                1440
Asp Phe Leu Glu Tyr Asp Gln Glu His Ile Arg Phe Ile Asp Asn Met
                1445                1450                1455    
Leu Met Gly Ser Gly Ala Phe Val Lys Lys Ile Ser Leu Ser Pro Phe
            1460                1465                1470        
Ser Thr Thr Asp Ser Ala Tyr Glu Trp Lys Met Pro Lys Lys Ser Ser
        1475                1480                1485            
Leu Gly Ser Met Pro Phe Ser Ser Asp Phe Glu Asp Phe Asp Tyr Ser
    1490                1495                1500                
Ser Trp Asp Ala Met Cys Tyr Leu Asp Pro Ser Lys Ala Val Glu Glu
1505                1510                1515                1520
Asp Asp Phe Val Val Gly Phe Trp Asn Pro Ser Glu Glu Asn Cys Gly
                1525                1530                1535    
Val Asp Thr Gly Lys Gln Ser Ile Ser Tyr Asp Leu His Thr Glu Gln
            1540                1545                1550        
Cys Ile Ala Asp Lys Ser Ile Ala Asp Cys Val Glu Ala Leu Leu Gly
        1555                1560                1565            
Cys Tyr Leu Thr Ser Cys Gly Glu Arg Ala Ala Gln Leu Phe Leu Cys
    1570                1575                1580                
Ser Leu Gly Leu Lys Val Leu Pro Val Ile Lys Arg Thr Asp Arg Glu
1585                1590                1595                1600
Lys Ala Leu Cys Pro Thr Arg Glu Asn Phe Asn Ser Gln Gln Lys Asn
                1605                1610                1615    
Leu Ser Val Ser Cys Ala Ala Ala Ser Val Ala Ser Ser Arg Ser Ser
            1620                1625                1630        
Val Leu Lys Asp Ser Glu Tyr Gly Cys Leu Lys Ile Pro Pro Arg Cys
        1635                1640                1645            
Met Phe Asp His Pro Asp Ala Asp Lys Thr Leu Asn His Leu Ile Ser
    1650                1655                1660                
Gly Phe Glu Asn Phe Glu Lys Lys Ile Asn Tyr Arg Phe Lys Asn Lys
1665                1670                1675                1680
Ala Tyr Leu Leu Gln Ala Phe Thr His Ala Ser Tyr His Tyr Asn Thr
                1685                1690                1695    
Ile Thr Asp Cys Tyr Gln Arg Leu Glu Phe Leu Gly Asp Ala Ile Leu
            1700                1705                1710        
Asp Tyr Leu Ile Thr Lys His Leu Tyr Glu Asp Pro Arg Gln His Ser
        1715                1720                1725            
Pro Gly Val Leu Thr Asp Leu Arg Ser Ala Leu Val Asn Asn Thr Ile
    1730                1735                1740                
Phe Ala Ser Leu Ala Val Lys Tyr Asp Tyr His Lys Tyr Phe Lys Ala
1745                1750                1755                1760
Val Ser Pro Glu Leu Phe His Val Ile Asp Asp Phe Val Gln Phe Gln
                1765                1770                1775    
Leu Glu Lys Asn Glu Met Gln Gly Met Asp Ser Glu Leu Arg Arg Ser
            1780                1785                1790        
Glu Glu Asp Glu Glu Lys Glu Glu Asp Ile Glu Val Pro Lys Ala Met
        1795                1800                1805            
Gly Asp Ile Phe Glu Ser Leu Ala Gly Ala Ile Tyr Met Asp Ser Gly
    1810                1815                1820                
Met Ser Leu Glu Thr Val Trp Gln Val Tyr Tyr Pro Met Met Arg Pro
1825                1830                1835                1840
Leu Ile Glu Lys Phe Ser Ala Asn Val Pro Arg Ser Pro Val Arg Glu
                1845                1850                1855    
Leu Leu Glu Met Glu Pro Glu Thr Ala Lys Phe Ser Pro Ala Glu Arg
            1860                1865                1870        
Thr Tyr Asp Gly Lys Val Arg Val Thr Val Glu Val Val Gly Lys Gly
        1875                1880                1885            
Lys Phe Lys Gly Val Gly Arg Ser Tyr Arg Ile Ala Lys Ser Ala Ala
    1890                1895                1900                
Ala Arg Arg Ala Leu Arg Ser Leu Lys Ala Asn Gln Pro Gln Leu Trp
1905                1910                1915                1920
Val Ser Leu Ala Leu Pro Ser Thr Tyr Gln
                1925                1930


<210> 22
<211> 1923
<212> PRT
<213> Canis familiaris

<400> 22
Met Lys Ser Pro Ala Leu Gln Pro Leu Ser Met Ala Gly Leu Gln Leu
 1               5                  10                  15      
Met Thr Pro Ala Ser Ser Pro Met Gly Pro Phe Phe Gly Leu Pro Trp
            20                  25                  30          
Gln Gln Glu Ala Ile His Asp Asn Ile Tyr Thr Pro Arg Lys Tyr Gln
        35                  40                  45              
Val Glu Leu Leu Glu Ala Ala Leu Asp His Asn Thr Ile Val Cys Leu
    50                  55                  60                  
Asn Thr Gly Ser Gly Lys Thr Phe Ile Ala Val Leu Leu Thr Lys Glu
65                  70                  75                  80  
Leu Ser Tyr Gln Ile Arg Gly Asp Phe Asn Arg Asn Gly Lys Arg Thr
                85                  90                  95      
Val Phe Leu Val Asn Ser Ala Asn Gln Val Ala Gln Gln Val Ser Ala
            100                 105                 110         
Val Arg Thr His Ser Asp Leu Lys Val Gly Glu Tyr Ser Asn Leu Glu
        115                 120                 125             
Val Asn Ala Ser Trp Thr Lys Glu Lys Trp Asn Gln Glu Phe Thr Lys
    130                 135                 140                 
His Gln Val Leu Val Met Thr Cys Tyr Val Ala Leu Asn Val Leu Lys
145                 150                 155                 160 
Asn Gly Tyr Leu Ser Leu Ser Asp Ile Asn Leu Leu Val Phe Asp Glu
                165                 170                 175     
Cys His Leu Ala Ile Leu Asp His Pro Tyr Arg Glu Ile Met Lys Leu
            180                 185                 190         
Cys Glu Asn Cys Pro Ser Cys Pro Arg Ile Leu Gly Leu Thr Ala Ser
        195                 200                 205             
Ile Leu Asn Gly Lys Cys Asp Pro Glu Glu Leu Glu Glu Lys Ile Gln
    210                 215                 220                 
Lys Leu Glu Lys Ile Leu Lys Ser Asn Ala Glu Thr Ala Thr Asp Leu
225                 230                 235                 240 
Val Val Leu Asp Arg Tyr Thr Ser Gln Pro Cys Glu Ile Val Val Asp
                245                 250                 255     
Cys Gly Pro Phe Thr Asp Arg Ser Gly Leu Tyr Gly Arg Leu Leu Val
            260                 265                 270         
Glu Leu Glu Glu Ala Leu Asn Phe Ile Asn Asp Cys Asn Ile Ser Val
        275                 280                 285             
His Ser Lys Glu Arg Asp Ser Thr Leu Ile Ser Lys Gln Ile Leu Ser
    290                 295                 300                 
Asp Cys Arg Ala Val Leu Val Val Leu Gly Pro Trp Cys Ala Asp Lys
305                 310                 315                 320 
Val Ala Gly Met Met Val Arg Glu Leu Gln Lys Tyr Ile Lys His Glu
                325                 330                 335     
Gln Glu Glu Leu His Arg Lys Phe Leu Leu Phe Thr Asp Thr Phe Leu
            340                 345                 350         
Arg Lys Ile His Ala Leu Cys Glu Glu His Phe Ser Pro Ala Ser Leu
        355                 360                 365             
Asp Leu Lys Phe Val Thr Pro Lys Val Ile Lys Leu Leu Glu Ile Leu
    370                 375                 380                 
Arg Lys Tyr Lys Pro Tyr Glu Arg Gln Gln Phe Glu Ser Val Glu Trp
385                 390                 395                 400 
Tyr Asn Asn Arg Asn Gln Asp Asn Tyr Val Ser Trp Ser Asp Ser Glu
                405                 410                 415     
Asp Asp Asp Glu Asp Glu Glu Ile Glu Glu Lys Glu Lys Pro Glu Thr
            420                 425                 430         
Asn Phe Pro Ser Pro Phe Thr Asn Ile Leu Cys Gly Ile Ile Phe Val
        435                 440                 445             
Glu Arg Arg Tyr Thr Ala Val Val Leu Asn Arg Leu Ile Lys Glu Ala
    450                 455                 460                 
Gly Lys Gln Asp Pro Glu Leu Ala Tyr Ile Ser Ser Asn Phe Ile Thr
465                 470                 475                 480 
Gly His Gly Ile Gly Lys Asn Gln Pro Arg Asn Lys Gln Met Glu Ala
                485                 490                 495     
Glu Phe Arg Lys Gln Glu Glu Val Leu Arg Lys Phe Arg Ala His Glu
            500                 505                 510         
Thr Asn Leu Leu Ile Ala Thr Ser Ile Val Glu Glu Gly Val Asp Ile
        515                 520                 525             
Pro Lys Cys Asn Leu Val Val Arg Phe Asp Leu Pro Thr Glu Tyr Arg
    530                 535                 540                 
Ser Tyr Val Gln Ser Lys Gly Arg Ala Arg Ala Pro Ile Ser Asn Tyr
545                 550                 555                 560 
Ile Met Leu Ala Asp Thr Asp Lys Ile Lys Ser Phe Glu Glu Asp Leu
                565                 570                 575     
Lys Thr Tyr Lys Ala Ile Glu Lys Ile Leu Arg Asn Lys Cys Ser Lys
            580                 585                 590         
Ser Val Asp Thr Gly Glu Thr Asp Ile Glu Pro Val Val Asp Asp Asp
        595                 600                 605             
Asp Val Phe Pro Pro Tyr Val Leu Arg Pro Asp Asp Gly Gly Pro Arg
    610                 615                 620                 
Val Thr Ile Asn Thr Ala Ile Gly His Ile Asn Arg Tyr Cys Ala Arg
625                 630                 635                 640 
Leu Pro Ser Asp Pro Phe Thr His Leu Ala Pro Lys Cys Arg Thr Arg
                645                 650                 655     
Glu Leu Pro Asp Gly Thr Phe Tyr Ser Thr Leu Tyr Leu Pro Ile Asn
            660                 665                 670         
Ser Pro Leu Arg Ala Ser Ile Val Gly Pro Pro Met Ser Cys Val Arg
        675                 680                 685             
Leu Ala Glu Arg Val Val Ala Leu Ile Cys Cys Glu Lys Leu His Lys
    690                 695                 700                 
Ile Gly Glu Leu Asp Asp His Leu Met Pro Val Gly Lys Glu Thr Val
705                 710                 715                 720 
Lys Tyr Glu Glu Glu Leu Asp Leu His Asp Glu Glu Glu Thr Ser Val
                725                 730                 735     
Pro Gly Arg Pro Gly Ser Thr Lys Arg Arg Gln Cys Tyr Pro Lys Ala
            740                 745                 750         
Ile Pro Glu Cys Leu Arg Asp Ser Tyr Pro Lys Pro Asp Gln Pro Cys
        755                 760                 765             
Tyr Leu Tyr Val Ile Gly Met Val Leu Thr Thr Pro Leu Pro Asp Glu
    770                 775                 780                 
Leu Asn Phe Arg Arg Arg Lys Leu Tyr Pro Pro Glu Asp Thr Thr Arg
785                 790                 795                 800 
Cys Phe Gly Ile Leu Thr Ala Lys Pro Ile Pro Gln Ile Pro His Phe
                805                 810                 815     
Pro Val Tyr Thr Arg Ser Gly Glu Val Thr Ile Ser Ile Glu Leu Lys
            820                 825                 830         
Lys Ser Gly Phe Thr Leu Ser Leu Gln Met Leu Glu Leu Ile Thr Arg
        835                 840                 845             
Leu His Gln Tyr Ile Phe Ser His Ile Leu Arg Leu Glu Lys Pro Ala
    850                 855                 860                 
Leu Glu Phe Lys Pro Thr Asp Ala Asp Ser Ala Tyr Cys Val Leu Pro
865                 870                 875                 880 
Leu Asn Val Val Asn Asp Ser Ser Thr Leu Asp Ile Asp Phe Lys Phe
                885                 890                 895     
Met Glu Asp Ile Glu Lys Ser Glu Ala Arg Ile Gly Ile Pro Ser Thr
            900                 905                 910         
Lys Tyr Ser Lys Glu Thr Pro Phe Val Phe Lys Leu Glu Asp Tyr Gln
        915                 920                 925             
Asp Ala Val Ile Ile Pro Arg Tyr Arg Asn Phe Asp Gln Pro His Arg
    930                 935                 940                 
Phe Tyr Val Ala Asp Val Tyr Thr Asp Leu Thr Pro Leu Ser Lys Phe
945                 950                 955                 960 
Pro Ser Pro Glu Tyr Glu Thr Phe Ala Glu Tyr Tyr Lys Thr Lys Tyr
                965                 970                 975     
Asn Leu Asp Leu Thr Asn Leu Asn Gln Pro Leu Leu Asp Val Asp His
            980                 985                 990         
Thr Ser Ser Arg Leu Asn Leu Leu Thr Pro Arg His Leu Asn Gln Lys
        995                 1000                1005            
Gly Lys Ala Leu Pro Leu Ser Ser Ala Glu Lys Arg Lys Ala Lys Trp
    1010                1015                1020                
Glu Ser Leu Gln Asn Lys Gln Ile Leu Val Pro Glu Leu Cys Ala Ile
1025                1030                1035                1040
His Pro Ile Pro Ala Ser Leu Trp Arg Lys Ala Val Cys Leu Pro Ser
                1045                1050                1055    
Ile Leu Tyr Arg Leu His Cys Leu Leu Thr Ala Glu Glu Leu Arg Ala
            1060                1065                1070        
Gln Thr Ala Ser Asp Ala Gly Val Gly Val Arg Ser Leu Pro Val Asp
        1075                1080                1085            
Phe Arg Tyr Pro Asn Leu Asp Phe Gly Trp Lys Lys Ser Ile Asp Ser
    1090                1095                1100                
Lys Ser Phe Ile Ser Val Ala Asn Ser Ser Ser Ala Glu Asn Glu Asn
1105                1110                1115                1120
Tyr Cys Lys His Ser Thr Ile Val Val Pro Glu Asn Ala Ala Arg Gln
                1125                1130                1135    
Gly Ala Asn Arg Thr Ser Ser Leu Glu Asn His Asp Gln Met Ser Val
            1140                1145                1150        
Asn Cys Arg Thr Leu Phe Ser Glu Ser Pro Gly Lys Leu Gln Ile Glu
        1155                1160                1165            
Val Val Thr Asp Leu Thr Ala Ile Asn Gly Leu Ser Tyr Asn Lys Asn
    1170                1175                1180                
Leu Ala Asn Gly Ser Tyr Asp Leu Ala Asn Arg Asp Phe Cys Gln Gly
1185                1190                1195                1200
Asn Gln Leu Asn Tyr Tyr Lys Gln Glu Ile Pro Val Gln Pro Thr Thr
                1205                1210                1215    
Ser Tyr Pro Ile Gln Asn Leu Tyr Asn Tyr Glu Asn Gln Pro Lys Pro
            1220                1225                1230        
Ser Asp Glu Cys Thr Leu Leu Ser Asn Lys Tyr Leu Asp Gly Asn Ala
        1235                1240                1245            
Asn Lys Ser Thr Ser Asp Gly Ser Pro Thr Thr Ala Ala Met Pro Gly
    1250                1255                1260                
Thr Thr Glu Ala Val Arg Ala Leu Lys Asp Lys Met Gly Ser Glu Gln
1265                1270                1275                1280
Ser Pro Cys Pro Gly Tyr Ser Ser Arg Thr Leu Gly Pro Asn Pro Gly
                1285                1290                1295    
Leu Ile Leu Gln Ala Leu Thr Leu Ser Asn Ala Ser Asp Gly Phe Asn
            1300                1305                1310        
Leu Glu Arg Leu Glu Met Leu Gly Asp Ser Phe Leu Lys His Ala Ile
        1315                1320                1325            
Thr Thr Tyr Leu Phe Cys Thr Tyr Pro Asp Ala His Glu Gly Arg Leu
    1330                1335                1340                
Ser Tyr Met Arg Ser Lys Lys Val Ser Asn Cys Asn Leu Tyr Arg Leu
1345                1350                1355                1360
Gly Lys Lys Lys Gly Leu Pro Ser Arg Met Val Val Ser Ile Phe Asp
                1365                1370                1375    
Pro Pro Val Asn Trp Leu Pro Pro Gly Tyr Val Val Asn Gln Asp Lys
            1380                1385                1390        
Ser Asn Ala Asp Lys Trp Glu Lys Asp Glu Met Thr Lys Asp Cys Met
        1395                1400                1405            
Leu Ala Asn Gly Lys Leu Asp Glu Asp Phe Glu Glu Asp Asp Glu Glu
    1410                1415                1420                
Glu Glu Asp Leu Met Trp Arg Ala Pro Lys Glu Asp Ala Asp Tyr Glu
1425                1430                1435                1440
Asp Asp Phe Leu Glu Tyr Asp Gln Glu His Ile Lys Phe Ile Asp Asn
                1445                1450                1455    
Met Leu Met Gly Ser Gly Ala Phe Val Lys Lys Ile Ser Leu Ser Pro
            1460                1465                1470        
Phe Ser Thr Thr Asp Ser Ala Tyr Glu Trp Lys Met Pro Lys Lys Ser
        1475                1480                1485            
Ser Leu Gly Ser Met Pro Phe Ser Ser Asp Phe Glu Asp Phe Asp Tyr
    1490                1495                1500                
Ser Ser Trp Asp Ala Met Cys Tyr Leu Asp Pro Ser Lys Ala Val Glu
1505                1510                1515                1520
Glu Asp Asp Phe Val Val Gly Phe Trp Asn Pro Ser Glu Glu Asn Cys
                1525                1530                1535    
Gly Val Asp Thr Gly Lys Gln Ser Ile Ser Tyr Asp Leu His Thr Glu
            1540                1545                1550        
Gln Cys Ile Ala Asp Lys Ser Ile Ala Asp Cys Val Glu Ala Leu Leu
        1555                1560                1565            
Gly Cys Tyr Leu Thr Ser Cys Gly Glu Arg Ala Ala Gln Leu Phe Leu
    1570                1575                1580                
Cys Ser Leu Gly Leu Lys Val Leu Pro Val Met Lys Arg Thr Asp Arg
1585                1590                1595                1600
Glu Lys Thr Met Cys Pro Pro Arg Glu Asn Phe Ser Ser Gln Gln Lys
                1605                1610                1615    
Asn Leu Ser Gly Gly Arg Ala Ala Ala Ser Val Ala Ser Leu Arg Pro
            1620                1625                1630        
Ser Val Leu Lys Asp Leu Glu Tyr Gly Cys Leu Lys Ile Pro Pro Arg
        1635                1640                1645            
Cys Met Phe Asp His Pro Asp Ala Asp Lys Thr Leu Asn His Leu Ile
    1650                1655                1660                
Ser Gly Phe Glu Asn Phe Glu Lys Lys Ile Asn Tyr Arg Phe Lys Asn
1665                1670                1675                1680
Lys Ala Tyr Leu Leu Gln Ala Phe Thr His Ala Ser Tyr His Tyr Asn
                1685                1690                1695    
Thr Ile Thr Asp Cys Tyr Gln Arg Leu Glu Phe Leu Gly Asp Ala Ile
            1700                1705                1710        
Leu Asp Tyr Leu Ile Thr Lys His Leu Tyr Glu Asp Pro Arg Gln His
        1715                1720                1725            
Ser Pro Gly Val Leu Thr Asp Leu Arg Ser Ala Leu Val Asn Asn Thr
    1730                1735                1740                
Ile Phe Ala Ser Leu Ala Val Lys Tyr Asp Tyr His Lys Tyr Phe Lys
1745                1750                1755                1760
Ala Val Ser Pro Glu Leu Phe His Val Ile Asp Asp Phe Val Gln Phe
                1765                1770                1775    
Gln Leu Glu Lys Asn Glu Met Gln Gly Met Asp Ser Glu Leu Arg Arg
            1780                1785                1790        
Ser Glu Glu Asp Glu Glu Lys Glu Glu Asp Ile Glu Val Pro Lys Ala
        1795                1800                1805            
Met Gly Asp Ile Phe Glu Ser Leu Ala Gly Ala Ile Tyr Met Asp Ser
    1810                1815                1820                
Gly Met Ser Leu Glu Met Val Trp Gln Val Tyr Tyr Pro Met Met Arg
1825                1830                1835                1840
Pro Leu Ile Glu Lys Phe Ser Ala Asn Val Pro Arg Ser Pro Val Arg
                1845                1850                1855    
Glu Leu Leu Glu Met Glu Pro Glu Thr Ala Lys Phe Ser Pro Ala Glu
            1860                1865                1870        
Arg Thr Tyr Asp Gly Lys Val Arg Val Thr Val Glu Val Val Gly Lys
        1875                1880                1885            
Gly Lys Phe Lys Gly Val Gly Arg Ser Tyr Arg Ile Ala Lys Ser Ala
    1890                1895                1900                
Ala Ala Arg Arg Ala Leu Arg Ser Leu Lys Ala Asn Gln Pro Gln Val
1905                1910                1915                1920
Pro Asn Ser
            


<210> 23
<211> 1918
<212> PRT
<213> Rattus norvegicus

<400> 23
Met Lys Ser Pro Ala Leu Gln Pro Leu Ser Met Ala Gly Leu Gln Leu
 1               5                  10                  15      
Met Thr Pro Ala Ser Ser Pro Met Gly Pro Phe Phe Gly Leu Pro Trp
            20                  25                  30          
Gln Gln Glu Ala Ile His Asp Asn Ile Tyr Thr Pro Arg Lys Tyr Gln
        35                  40                  45              
Val Glu Leu Leu Glu Ala Ala Leu Asp His Asn Thr Ile Val Cys Leu
    50                  55                  60                  
Asn Thr Gly Ser Gly Lys Thr Phe Ile Ala Val Leu Leu Thr Lys Glu
65                  70                  75                  80  
Leu Ala His Gln Ile Arg Gly Asp Leu Ser Pro His Ala Lys Arg Thr
                85                  90                  95      
Val Phe Leu Val Asn Ser Ala Asn Gln Val Ala Gln Gln Val Ser Ala
            100                 105                 110         
Val Arg Thr His Ser Asp Leu Lys Val Gly Glu Tyr Ser Asn Leu Glu
        115                 120                 125             
Val Asn Ala Ser Trp Thr Lys Glu Arg Trp Ser Gln Glu Phe Thr Lys
    130                 135                 140                 
His Gln Val Leu Ile Met Thr Cys Tyr Val Ala Leu Asn Val Leu Lys
145                 150                 155                 160 
Asn Gly Tyr Leu Ser Leu Ser Asp Ile Asn Leu Leu Val Phe Asp Glu
                165                 170                 175     
Cys His Leu Ala Ile Leu Asp His Pro Tyr Arg Glu Ile Met Lys Leu
            180                 185                 190         
Cys Asp Ser Cys Pro Ser Cys Pro Arg Ile Leu Gly Leu Thr Ala Ser
        195                 200                 205             
Ile Leu Asn Gly Lys Cys Asp Pro Asp Glu Leu Glu Glu Lys Ile Gln
    210                 215                 220                 
Lys Leu Glu Lys Ile Leu Lys Ser Gly Ala Glu Thr Ala Thr Asp Leu
225                 230                 235                 240 
Val Val Leu Asp Arg Tyr Thr Ser Gln Pro Cys Glu Ile Val Val Asp
                245                 250                 255     
Cys Gly Pro Phe Thr Asp Arg Ser Gly Leu Tyr Glu Arg Leu Leu Met
            260                 265                 270         
Glu Leu Glu Glu Ala Leu Asp Phe Ile Asn Asp Cys Asn Val Ser Val
        275                 280                 285             
His Ser Lys Glu Arg Asp Ser Thr Leu Ile Ser Lys Gln Ile Leu Ser
    290                 295                 300                 
Asp Cys Arg Ala Val Leu Val Val Leu Gly Pro Trp Cys Ala Asp Lys
305                 310                 315                 320 
Val Ala Gly Met Met Val Arg Glu Leu Gln Lys Tyr Ile Lys His Glu
                325                 330                 335     
Gln Glu Glu Leu His Arg Lys Phe Leu Leu Phe Thr Asp Thr Leu Leu
            340                 345                 350         
Arg Lys Ile His Ala Leu Cys Glu Glu Tyr Phe Ser Pro Ala Ser Leu
        355                 360                 365             
Asp Leu Lys Tyr Val Thr Pro Lys Val Met Lys Leu Leu Glu Ile Leu
    370                 375                 380                 
Arg Lys Tyr Lys Pro Tyr Glu Arg Gln Gln Phe Glu Ser Val Glu Trp
385                 390                 395                 400 
Tyr Asn Asn Arg Asn Gln Asp Asn Tyr Val Ser Trp Ser Asp Ser Glu
                405                 410                 415     
Asp Asp Asp Asp Asp Glu Glu Ile Glu Glu Lys Glu Lys Pro Glu Thr
            420                 425                 430         
Asn Phe Pro Ser Pro Phe Thr Asn Ile Leu Cys Gly Ile Ile Phe Val
        435                 440                 445             
Glu Arg Arg Tyr Thr Ala Val Val Leu Asn Arg Leu Ile Lys Glu Ala
    450                 455                 460                 
Gly Lys Gln Asp Pro Glu Leu Ala Tyr Ile Ser Ser Asn Phe Ile Thr
465                 470                 475                 480 
Gly His Gly Ile Gly Lys Asn Gln Pro Arg Ser Lys Gln Met Glu Ala
                485                 490                 495     
Glu Phe Arg Lys Gln Glu Glu Val Leu Arg Lys Phe Arg Ala His Glu
            500                 505                 510         
Thr Asn Leu Leu Ile Ala Thr Ser Val Val Glu Glu Gly Val Asp Ile
        515                 520                 525             
Pro Lys Cys Asn Leu Val Val Arg Phe Asp Leu Pro Thr Glu Tyr Arg
    530                 535                 540                 
Ser Tyr Val Gln Ser Lys Gly Arg Ala Arg Ala Pro Ile Ser Asn Tyr
545                 550                 555                 560 
Val Met Leu Ala Asp Thr Asp Lys Ile Lys Ser Phe Glu Glu Asp Leu
                565                 570                 575     
Lys Thr Tyr Lys Ala Ile Glu Lys Ile Leu Arg Asn Lys Cys Ser Lys
            580                 585                 590         
Ser Val Asp Gly Ala Glu Ala Asp Val His Ala Val Val Asp Asp Asp
        595                 600                 605             
Asp Val Phe Pro Pro Tyr Val Leu Arg Pro Asp Asp Gly Gly Pro Arg
    610                 615                 620                 
Val Thr Ile Asn Thr Ala Ile Gly His Ile Asn Arg Tyr Cys Ala Arg
625                 630                 635                 640 
Leu Pro Ser Asp Pro Phe Thr His Leu Ala Pro Lys Cys Arg Thr Arg
                645                 650                 655     
Glu Leu Pro Asp Gly Thr Phe Tyr Ser Thr Leu Tyr Leu Pro Ile Asn
            660                 665                 670         
Ser Pro Leu Arg Ala Ser Ile Val Gly Pro Pro Met Gly Cys Val Arg
        675                 680                 685             
Leu Ala Glu Arg Val Val Ala Leu Ile Cys Cys Glu Lys Leu His Lys
    690                 695                 700                 
Ile Gly Glu Leu Asp Glu His Leu Met Pro Val Gly Lys Glu Thr Val
705                 710                 715                 720 
Lys Tyr Glu Glu Glu Leu Asp Leu His Asp Glu Glu Glu Thr Ser Val
                725                 730                 735     
Pro Gly Arg Pro Gly Ser Thr Lys Arg Arg Gln Cys Tyr Pro Lys Ala
            740                 745                 750         
Ile Pro Glu Cys Leu Arg Glu Ser Tyr Pro Lys Pro Asp Gln Pro Cys
        755                 760                 765             
Tyr Leu Tyr Val Ile Gly Met Val Leu Thr Thr Pro Leu Pro Asp Glu
    770                 775                 780                 
Leu Asn Phe Arg Arg Arg Lys Leu Tyr Pro Pro Glu Asp Thr Thr Arg
785                 790                 795                 800 
Cys Phe Gly Ile Leu Thr Ala Lys Pro Ile Pro Gln Ile Pro His Phe
                805                 810                 815     
Pro Val Tyr Thr Arg Ser Gly Glu Val Thr Ile Ser Ile Glu Leu Lys
            820                 825                 830         
Lys Ser Gly Phe Thr Leu Ser Gln Gln Met Leu Glu Leu Val Thr Arg
        835                 840                 845             
Leu His Gln Tyr Ile Phe Ser His Ile Leu Arg Leu Glu Lys Pro Ala
    850                 855                 860                 
Leu Glu Phe Gln Pro Ala Gly Ala Glu Ser Ala Tyr Cys Val Leu Pro
865                 870                 875                 880 
Leu Asn Val Val Asn Asp Ser Ser Thr Leu Asp Ile Asp Phe Lys Phe
                885                 890                 895     
Met Glu Asp Ile Glu Lys Ser Glu Ala Arg Ile Gly Ile Pro Ser Thr
            900                 905                 910         
Lys Tyr Ser Lys Glu Thr Pro Phe Val Phe Lys Leu Glu Asp Tyr Gln
        915                 920                 925             
Asp Ala Val Ile Ile Pro Arg Tyr Arg Asn Phe Asp Gln Pro His Arg
    930                 935                 940                 
Phe Tyr Val Ala Asp Val Tyr Thr Asp Leu Thr Pro Leu Ser Lys Phe
945                 950                 955                 960 
Pro Ser Pro Glu Tyr Glu Thr Phe Ala Glu Tyr Tyr Lys Thr Lys Tyr
                965                 970                 975     
Asn Leu Asp Leu Thr Asn Leu Asn Gln Pro Leu Leu Asp Val Asp His
            980                 985                 990         
Thr Ser Ser Arg Leu Asn Leu Leu Thr Pro Arg His Leu Asn Gln Lys
        995                 1000                1005            
Gly Lys Ala Leu Pro Leu Ser Ser Ala Glu Lys Arg Lys Ala Lys Trp
    1010                1015                1020                
Glu Ser Leu Gln Asn Lys Gln Ile Leu Val Pro Glu Leu Cys Ala Ile
1025                1030                1035                1040
His Pro Ile Pro Ala Ser Leu Trp Arg Lys Ala Val Cys Leu Pro Ser
                1045                1050                1055    
Ile Leu Tyr Arg Leu His Cys Leu Leu Thr Ala Glu Glu Leu Arg Ala
            1060                1065                1070        
Gln Thr Ala Ser Asp Ala Gly Val Gly Val Arg Ser Leu Pro Ala Asp
        1075                1080                1085            
Phe Arg Tyr Pro Asn Leu Asp Phe Gly Trp Lys Lys Ser Ile Asp Ser
    1090                1095                1100                
Lys Ser Phe Ile Ser Thr Cys Asn Ser Ser Leu Ala Glu Ser Asp Asn
1105                1110                1115                1120
Tyr Cys Lys His Ser Thr Thr Val Val Pro Glu Asn Ala Ala His Gln
                1125                1130                1135    
Gly Ala Thr Arg Pro Ser Leu Glu Asn His Asp Gln Met Ser Val Asn
            1140                1145                1150        
Cys Lys Arg Leu Pro Ala Glu Ser Pro Ala Lys Leu Gln Ser Glu Val
        1155                1160                1165            
Ser Val Asp Leu Thr Ala Ile Asn Gly Leu Ser Tyr Asn Lys Ser Leu
    1170                1175                1180                
Ala Asn Gly Ser Tyr Asp Leu Val Asn Arg Asp Phe Cys Gln Gly Asn
1185                1190                1195                1200
Gln Leu Thr Tyr Phe Lys Gln Glu Ile Pro Val Gln Pro Thr Thr Ser
                1205                1210                1215    
Tyr Pro Ile Gln Asn Leu Tyr Asn Tyr Glu Asn Gln Pro Thr Pro Ser
            1220                1225                1230        
Asn Glu Cys Pro Leu Leu Ser Asn Lys Tyr Leu Asp Gly Asn Ala Asn
        1235                1240                1245            
Thr Ser Thr Ser Asp Gly Ser Pro Ala Gly Ser Pro Arg Pro Ala Met
    1250                1255                1260                
Met Thr Ala Val Glu Ala Leu Glu Gly Arg Thr Asp Ser Glu Gln Ser
1265                1270                1275                1280
Pro Ser Val Gly His Ser Ser Arg Thr Leu Gly Pro Asn Pro Gly Leu
                1285                1290                1295    
Ile Leu Gln Ala Leu Thr Leu Ser Asn Ala Ser Asp Gly Phe Asn Leu
            1300                1305                1310        
Glu Arg Leu Glu Met Leu Gly Asp Ser Phe Leu Lys His Ala Ile Thr
        1315                1320                1325            
Thr Tyr Leu Phe Cys Thr Tyr Pro Asp Ala His Glu Gly Arg Leu Ser
    1330                1335                1340                
Tyr Met Arg Ser Lys Lys Val Ser Asn Cys Asn Leu Tyr Arg Leu Gly
1345                1350                1355                1360
Lys Lys Gln Gly Leu Pro Ser Arg Met Val Val Ser Ile Phe Asp Pro
                1365                1370                1375    
Pro Val Asn Trp Leu Pro Pro Gly Tyr Val Val Asn Gln Asp Lys Ser
            1380                1385                1390        
Asn Ser Glu Lys Trp Glu Lys Asp Glu Met Thr Lys Asp Cys Leu Leu
        1395                1400                1405            
Ala Asn Gly Lys Leu Gly Glu Asp Cys Glu Glu Glu Glu Glu Glu Glu
    1410                1415                1420                
Leu Ala Trp Arg Ala Pro Lys Glu Glu Ala Glu Tyr Glu Asp Asp Leu
1425                1430                1435                1440
Leu Glu Tyr Asp Gln Glu His Ile Gln Phe Ile Asp Ser Met Leu Met
                1445                1450                1455    
Gly Ser Gly Ala Phe Val Lys Lys Ile Pro Leu Ser Pro Phe Ser Thr
            1460                1465                1470        
Ser Asp Ser Ala Tyr Glu Trp Lys Met Pro Lys Lys Ala Ser Leu Gly
        1475                1480                1485            
Ser Val Pro Phe Ser Ser Asp Leu Glu Asp Phe Asp Tyr Ser Ser Trp
    1490                1495                1500                
Asp Ala Met Cys Tyr Leu Asp Pro Ser Lys Ala Val Glu Glu Asp Asp
1505                1510                1515                1520
Phe Val Val Gly Phe Trp Asn Pro Ser Glu Glu Asn Cys Gly Val Asp
                1525                1530                1535    
Thr Gly Lys Gln Ser Ile Ser Tyr Asp Leu His Thr Glu Gln Cys Ile
            1540                1545                1550        
Ala Asp Lys Ser Ile Ala Asp Cys Val Glu Ala Leu Leu Gly Cys Tyr
        1555                1560                1565            
Leu Thr Ser Cys Gly Glu Arg Ala Ala Gln Leu Phe Leu Cys Ser Leu
    1570                1575                1580                
Gly Leu Lys Val Leu Pro Val Ile Lys Arg Thr Ser Arg Asp Lys Ala
1585                1590                1595                1600
Ser Tyr Pro Ala Gln Glu Asn Ser Ser Ser Gln Gln Lys Ser Pro Ser
                1605                1610                1615    
Gly Ser Cys Ala Ala Ala Val Ser Pro Arg Ser Ser Ala Gly Lys Asp
            1620                1625                1630        
Leu Glu Tyr Gly Cys Leu Lys Ile Pro Pro Arg Cys Met Phe Asp His
        1635                1640                1645            
Pro Asp Ala Glu Lys Thr Leu Asn His Leu Ile Ser Gly Phe Glu Asn
    1650                1655                1660                
Phe Glu Lys Lys Ile Asn Tyr Ile Phe Lys Asn Lys Ala Tyr Leu Leu
1665                1670                1675                1680
Gln Ala Phe Thr His Ala Ser Tyr His Tyr Asn Thr Ile Thr Asp Cys
                1685                1690                1695    
Tyr Gln Arg Leu Glu Phe Leu Gly Asp Ala Ile Leu Asp Tyr Leu Ile
            1700                1705                1710        
Thr Lys His Leu Tyr Glu Asp Pro Arg Gln His Ser Pro Gly Val Leu
        1715                1720                1725            
Thr Asp Leu Arg Ser Ala Leu Val Asn Asn Thr Ile Phe Ala Ser Leu
    1730                1735                1740                
Ala Val Lys Tyr Asp Tyr His Lys Tyr Phe Lys Ala Val Ser Pro Glu
1745                1750                1755                1760
Leu Phe His Val Ile Asp Asp Phe Val Gln Phe Gln Leu Glu Lys Asn
                1765                1770                1775    
Glu Met Gln Gly Met Asp Ser Glu Leu Arg Arg Ser Glu Glu Asp Glu
            1780                1785                1790        
Glu Lys Glu Glu Asp Ile Glu Val Pro Lys Ala Met Gly Asp Ile Phe
        1795                1800                1805            
Glu Ser Leu Ala Gly Ala Ile Tyr Met Asp Ser Gly Met Ser Leu Glu
    1810                1815                1820                
Val Val Trp Gln Val Tyr Tyr Pro Met Met Arg Pro Leu Ile Glu Lys
1825                1830                1835                1840
Phe Ser Ala Asn Val Pro Arg Ser Pro Val Arg Glu Leu Leu Glu Met
                1845                1850                1855    
Glu Pro Glu Thr Ala Lys Phe Ser Pro Ala Glu Arg Thr Tyr Asp Gly
            1860                1865                1870        
Lys Val Arg Val Thr Val Glu Val Val Gly Lys Gly Lys Phe Lys Gly
        1875                1880                1885            
Val Gly Arg Ser Tyr Arg Ile Ala Lys Ser Ala Ala Ala Arg Arg Ala
    1890                1895                1900                
Leu Arg Ser Leu Lys Ala Asn Gln Pro Leu Val Pro Asn Ser
1905                1910                1915            


<210> 24
<211> 1916
<212> PRT
<213> Mus musculus

<400> 24
Leu Lys Ser Pro Ala Leu Gln Pro Leu Ser Met Ala Gly Leu Gln Leu
 1               5                  10                  15      
Met Thr Pro Ala Ser Ser Pro Met Gly Pro Phe Phe Gly Leu Pro Trp
            20                  25                  30          
Gln Gln Glu Ala Ile His Asp Asn Ile Tyr Thr Pro Arg Lys Tyr Gln
        35                  40                  45              
Val Glu Leu Leu Glu Ala Ala Leu Asp His Asn Thr Ile Val Cys Leu
    50                  55                  60                  
Asn Thr Gly Ser Gly Lys Thr Phe Ile Ala Val Leu Leu Thr Lys Glu
65                  70                  75                  80  
Leu Ala His Gln Ile Arg Gly Asp Leu Asn Pro His Ala Lys Arg Thr
                85                  90                  95      
Val Phe Leu Val Asn Ser Ala Asn Gln Val Ala Gln Gln Val Ser Ala
            100                 105                 110         
Val Arg Thr His Ser Asp Leu Lys Val Gly Glu Tyr Ser Asp Leu Glu
        115                 120                 125             
Val Asn Ala Ser Trp Thr Lys Glu Arg Trp Ser Gln Glu Phe Thr Lys
    130                 135                 140                 
His Gln Val Leu Ile Met Thr Cys Tyr Val Ala Leu Thr Val Leu Lys
145                 150                 155                 160 
Asn Gly Tyr Leu Ser Leu Ser Asp Ile Asn Leu Leu Val Phe Asp Glu
                165                 170                 175     
Cys His Leu Ala Ile Leu Asp His Pro Tyr Arg Glu Ile Met Lys Leu
            180                 185                 190         
Cys Glu Ser Cys Pro Ser Cys Pro Arg Ile Leu Gly Leu Thr Ala Ser
        195                 200                 205             
Ile Leu Asn Gly Lys Cys Asp Pro Glu Glu Leu Glu Glu Lys Ile Gln
    210                 215                 220                 
Lys Leu Glu Arg Ile Leu Arg Ser Asp Ala Glu Thr Ala Thr Asp Leu
225                 230                 235                 240 
Val Val Leu Asp Arg Tyr Thr Ser Gln Pro Cys Glu Ile Val Val Asp
                245                 250                 255     
Cys Gly Pro Phe Thr Asp Arg Ser Gly Leu Tyr Glu Arg Leu Leu Met
            260                 265                 270         
Glu Leu Glu Ala Ala Leu Asp Phe Ile Asn Asp Cys Asn Val Ala Val
        275                 280                 285             
His Ser Lys Glu Arg Asp Ser Thr Leu Ile Ser Lys Gln Ile Leu Ser
    290                 295                 300                 
Asp Cys Arg Ala Val Leu Val Val Leu Gly Pro Trp Cys Ala Asp Lys
305                 310                 315                 320 
Val Ala Gly Met Met Val Arg Glu Leu Gln Lys Tyr Ile Lys His Glu
                325                 330                 335     
Gln Glu Glu Leu His Arg Lys Phe Leu Leu Phe Thr Asp Thr Leu Leu
            340                 345                 350         
Arg Lys Ile His Ala Leu Cys Glu Glu Tyr Phe Ser Pro Ala Ser Leu
        355                 360                 365             
Asp Leu Lys Tyr Val Thr Pro Lys Val Met Lys Leu Leu Glu Ile Leu
    370                 375                 380                 
Arg Lys Tyr Lys Pro Tyr Glu Arg Gln Gln Phe Glu Ser Val Glu Trp
385                 390                 395                 400 
Tyr Asn Asn Arg Asn Gln Asp Asn Tyr Val Ser Trp Ser Asp Ser Glu
                405                 410                 415     
Asp Asp Asp Asp Asp Glu Glu Ile Glu Glu Lys Glu Lys Pro Glu Thr
            420                 425                 430         
Asn Phe Pro Ser Pro Phe Thr Asn Ile Leu Cys Gly Ile Ile Phe Val
        435                 440                 445             
Glu Arg Arg Tyr Thr Ala Val Val Leu Asn Arg Leu Ile Lys Glu Ala
    450                 455                 460                 
Gly Lys Gln Asp Pro Glu Leu Ala Tyr Ile Ser Ser Asn Phe Ile Thr
465                 470                 475                 480 
Gly His Gly Ile Gly Lys Asn Gln Pro Arg Ser Lys Gln Met Glu Ala
                485                 490                 495     
Glu Phe Arg Lys Gln Glu Glu Val Leu Arg Lys Phe Arg Ala His Glu
            500                 505                 510         
Thr Asn Leu Leu Ile Ala Thr Ser Val Val Glu Glu Gly Val Asp Ile
        515                 520                 525             
Pro Lys Cys Asn Leu Val Val Arg Phe Asp Leu Pro Thr Glu Tyr Arg
    530                 535                 540                 
Ser Tyr Val Gln Ser Lys Gly Arg Ala Arg Ala Pro Ile Ser Asn Tyr
545                 550                 555                 560 
Val Met Leu Ala Asp Thr Asp Lys Ile Lys Ser Phe Glu Glu Asp Leu
                565                 570                 575     
Lys Thr Tyr Lys Ala Ile Glu Lys Ile Leu Arg Asn Lys Cys Ser Lys
            580                 585                 590         
Ser Ala Asp Gly Ala Glu Ala Asp Val His Ala Gly Val Asp Asp Glu
        595                 600                 605             
Asp Ala Phe Pro Pro Tyr Val Leu Arg Pro Asp Asp Gly Gly Pro Arg
    610                 615                 620                 
Val Thr Ile Asn Thr Ala Ile Gly His Ile Asn Arg Tyr Cys Ala Arg
625                 630                 635                 640 
Leu Pro Ser Asp Pro Phe Thr His Leu Ala Pro Lys Cys Arg Thr Arg
                645                 650                 655     
Glu Leu Pro Asp Gly Thr Phe Tyr Ser Thr Leu Tyr Leu Pro Ile Asn
            660                 665                 670         
Ser Pro Leu Arg Ala Ser Ile Val Gly Pro Pro Met Asp Ser Val Arg
        675                 680                 685             
Leu Ala Glu Arg Val Val Ala Leu Ile Cys Cys Glu Lys Leu His Lys
    690                 695                 700                 
Ile Gly Glu Leu Asp Glu His Leu Met Pro Val Gly Lys Glu Thr Val
705                 710                 715                 720 
Lys Tyr Glu Glu Glu Leu Asp Leu His Asp Glu Glu Glu Thr Ser Val
                725                 730                 735     
Pro Gly Arg Pro Gly Ser Thr Lys Arg Arg Gln Cys Tyr Pro Lys Ala
            740                 745                 750         
Ile Pro Glu Cys Leu Arg Glu Ser Tyr Pro Lys Pro Asp Gln Pro Cys
        755                 760                 765             
Tyr Leu Tyr Val Ile Gly Met Val Leu Thr Thr Pro Leu Pro Asp Glu
    770                 775                 780                 
Leu Asn Phe Arg Arg Arg Lys Leu Tyr Pro Pro Glu Asp Thr Thr Arg
785                 790                 795                 800 
Cys Phe Gly Ile Leu Thr Ala Lys Pro Ile Pro Gln Ile Pro His Phe
                805                 810                 815     
Pro Val Tyr Thr Arg Ser Gly Glu Val Thr Ile Ser Ile Glu Leu Lys
            820                 825                 830         
Lys Ser Gly Phe Thr Leu Ser Gln Gln Met Leu Glu Leu Ile Thr Arg
        835                 840                 845             
Leu His Gln Tyr Ile Phe Ser His Ile Leu Arg Leu Glu Lys Pro Ala
    850                 855                 860                 
Leu Glu Phe Lys Pro Thr Gly Ala Glu Ser Ala Tyr Cys Val Leu Pro
865                 870                 875                 880 
Leu Asn Val Val Asn Asp Ser Gly Thr Leu Asp Ile Asp Phe Lys Phe
                885                 890                 895     
Met Glu Asp Ile Glu Lys Ser Glu Ala Arg Ile Gly Ile Pro Ser Thr
            900                 905                 910         
Lys Tyr Ser Lys Glu Thr Pro Phe Val Phe Lys Leu Glu Asp Tyr Gln
        915                 920                 925             
Asp Ala Val Ile Ile Pro Arg Tyr Arg Asn Phe Asp Gln Pro His Arg
    930                 935                 940                 
Phe Tyr Val Ala Asp Val Tyr Thr Asp Leu Thr Pro Leu Ser Lys Phe
945                 950                 955                 960 
Pro Ser Pro Glu Tyr Glu Thr Phe Ala Glu Tyr Tyr Lys Thr Lys Tyr
                965                 970                 975     
Asn Leu Asp Leu Thr Asn Leu Asn Gln Pro Leu Leu Asp Val Asp His
            980                 985                 990         
Thr Ser Ser Arg Leu Asn Leu Leu Thr Pro Arg His Leu Asn Gln Lys
        995                 1000                1005            
Gly Lys Ala Leu Pro Leu Ser Ser Ala Glu Lys Arg Lys Ala Lys Trp
    1010                1015                1020                
Glu Ser Leu Gln Asn Lys Gln Ile Leu Val Pro Glu Leu Cys Ala Ile
1025                1030                1035                1040
His Pro Ile Pro Ala Ser Leu Trp Arg Lys Ala Val Cys Leu Pro Ser
                1045                1050                1055    
Ile Leu Tyr Arg Leu His Cys Leu Leu Thr Ala Glu Glu Leu Arg Ala
            1060                1065                1070        
Gln Thr Ala Ser Asp Ala Gly Val Gly Val Arg Ser Leu Pro Val Asp
        1075                1080                1085            
Phe Arg Tyr Pro Asn Leu Asp Phe Gly Trp Lys Lys Ser Ile Asp Ser
    1090                1095                1100                
Lys Ser Phe Ile Ser Ser Cys Asn Ser Ser Leu Ala Glu Ser Asp Asn
1105                1110                1115                1120
Tyr Cys Lys His Ser Thr Thr Val Val Pro Glu His Ala Ala His Gln
                1125                1130                1135    
Gly Ala Thr Arg Pro Ser Leu Glu Asn His Asp Gln Met Ser Val Asn
            1140                1145                1150        
Cys Lys Arg Leu Pro Ala Glu Ser Pro Ala Lys Leu Gln Ser Glu Val
        1155                1160                1165            
Ser Thr Asp Leu Thr Ala Ile Asn Gly Leu Ser Tyr Asn Lys Asn Leu
    1170                1175                1180                
Ala Asn Gly Ser Tyr Asp Leu Val Asn Arg Asp Phe Cys Gln Gly Asn
1185                1190                1195                1200
Gln Leu Asn Tyr Phe Lys Gln Glu Ile Pro Val Gln Pro Thr Thr Ser
                1205                1210                1215    
Tyr Pro Ile Gln Asn Leu Tyr Asn Tyr Glu Asn Gln Pro Lys Pro Ser
            1220                1225                1230        
Asn Glu Cys Pro Leu Leu Ser Asn Thr Tyr Leu Asp Gly Asn Ala Asn
        1235                1240                1245            
Thr Ser Thr Ser Asp Gly Ser Pro Ala Val Ser Thr Met Pro Ala Met
    1250                1255                1260                
Met Asn Ala Val Lys Ala Leu Lys Asp Arg Met Asp Ser Glu Gln Ser
1265                1270                1275                1280
Pro Ser Val Gly Tyr Ser Ser Arg Thr Leu Gly Pro Asn Pro Gly Leu
                1285                1290                1295    
Ile Leu Gln Ala Leu Thr Leu Ser Asn Ala Ser Asp Gly Phe Asn Leu
            1300                1305                1310        
Glu Arg Leu Glu Met Leu Gly Asp Ser Phe Leu Lys His Ala Ile Thr
        1315                1320                1325            
Thr Tyr Leu Phe Cys Thr Tyr Pro Asp Ala His Glu Gly Arg Leu Ser
    1330                1335                1340                
Tyr Met Arg Ser Lys Lys Val Ser Asn Cys Asn Leu Tyr Arg Leu Gly
1345                1350                1355                1360
Lys Lys Lys Gly Leu Pro Ser Arg Met Val Val Ser Ile Phe Asp Pro
                1365                1370                1375    
Pro Val Asn Trp Leu Pro Pro Gly Tyr Val Val Asn Gln Asp Lys Ser
            1380                1385                1390        
Asn Ser Glu Lys Trp Glu Lys Asp Glu Met Thr Lys Asp Cys Leu Leu
        1395                1400                1405            
Ala Asn Gly Lys Leu Gly Glu Ala Cys Glu Glu Glu Glu Asp Leu Thr
    1410                1415                1420                
Trp Arg Ala Pro Lys Glu Glu Ala Glu Asp Glu Asp Asp Phe Leu Glu
1425                1430                1435                1440
Tyr Asp Gln Glu His Ile Gln Phe Ile Asp Ser Met Leu Met Gly Ser
                1445                1450                1455    
Gly Ala Phe Val Arg Lys Ile Ser Leu Ser Pro Phe Ser Ala Ser Asp
            1460                1465                1470        
Ser Ala Tyr Glu Trp Lys Met Pro Lys Lys Ala Ser Leu Gly Ser Met
        1475                1480                1485            
Pro Phe Ala Ser Gly Leu Glu Asp Phe Asp Tyr Ser Ser Trp Asp Ala
    1490                1495                1500                
Met Cys Tyr Leu Asp Pro Ser Lys Ala Val Glu Glu Asp Asp Phe Val
1505                1510                1515                1520
Val Gly Phe Trp Asn Pro Ser Glu Glu Asn Cys Gly Val Asp Thr Gly
                1525                1530                1535    
Lys Gln Ser Ile Ser Tyr Asp Leu His Thr Glu Gln Cys Ile Ala Asp
            1540                1545                1550        
Lys Ser Ile Ala Asp Cys Val Glu Ala Leu Leu Gly Cys Tyr Leu Thr
        1555                1560                1565            
Ser Cys Gly Glu Arg Ala Ala Gln Leu Phe Leu Cys Ser Leu Gly Leu
    1570                1575                1580                
Lys Val Leu Pro Val Ile Lys Arg Thr Ser Arg Glu Lys Ala Leu Asp
1585                1590                1595                1600
Pro Ala Gln Glu Asn Gly Ser Ser Gln Gln Lys Ser Leu Ser Gly Ser
                1605                1610                1615    
Cys Ala Ser Pro Val Gly Pro Arg Ser Ser Ala Gly Lys Asp Leu Glu
            1620                1625                1630        
Tyr Gly Cys Leu Lys Ile Pro Pro Arg Cys Met Phe Asp His Pro Asp
        1635                1640                1645            
Ala Glu Lys Thr Leu Asn His Leu Ile Ser Gly Phe Glu Thr Phe Glu
    1650                1655                1660                
Lys Lys Ile Asn Tyr Arg Phe Lys Asn Lys Ala Tyr Leu Leu Gln Ala
1665                1670                1675                1680
Phe Thr His Ala Ser Tyr His Tyr Asn Thr Ile Thr Asp Cys Tyr Gln
                1685                1690                1695    
Arg Leu Glu Phe Leu Gly Asp Ala Ile Leu Asp Tyr Leu Ile Thr Lys
            1700                1705                1710        
His Leu Tyr Glu Asp Pro Arg Gln His Ser Pro Gly Val Leu Thr Asp
        1715                1720                1725            
Leu Arg Ser Ala Leu Val Asn Asn Thr Ile Phe Ala Ser Leu Ala Val
    1730                1735                1740                
Lys Tyr Asp Tyr His Lys Tyr Phe Lys Ala Val Ser Pro Glu Leu Phe
1745                1750                1755                1760
His Val Ile Asp Asp Phe Val Lys Phe Gln Leu Glu Lys Asn Glu Met
                1765                1770                1775    
Gln Gly Met Asp Ser Glu Leu Arg Arg Ser Glu Glu Asp Glu Glu Lys
            1780                1785                1790        
Glu Glu Asp Ile Glu Val Pro Lys Ala Met Gly Asp Ile Phe Glu Ser
        1795                1800                1805            
Leu Ala Gly Ala Ile Tyr Met Asp Ser Gly Met Ser Leu Glu Val Val
    1810                1815                1820                
Trp Gln Val Tyr Tyr Pro Met Met Gln Pro Leu Ile Glu Lys Phe Ser
1825                1830                1835                1840
Ala Asn Val Pro Arg Ser Pro Val Arg Glu Leu Leu Glu Met Glu Pro
                1845                1850                1855    
Glu Thr Ala Lys Phe Ser Pro Ala Glu Arg Thr Tyr Asp Gly Lys Val
            1860                1865                1870        
Arg Val Thr Val Glu Val Val Gly Lys Gly Lys Phe Lys Gly Val Gly
        1875                1880                1885            
Arg Ser Tyr Arg Ile Ala Lys Ser Ala Ala Ala Arg Arg Ala Leu Arg
    1890                1895                1900                
Ser Leu Lys Ala Asn Gln Pro Gln Val Pro Asn Ser
1905                1910                1915    


<210> 25
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic polypeptide

<400> 25
Asp Glu Cys His
 1              

