                         SEQUENCE LISTING

<110>  Cohen, Edward P.
 
<120>  Therapeutic Cancer Antigens

<130>  09-223-WO

<150>  61/036,713
<151>  2008-03-14

<160>  87    

<170>  PatentIn version 3.5

<210>  1
<211>  4799
<212>  DNA
<213>  Mus musculus - Grb10


<220>
<221>  CDS
<222>  (175)..(1800)

<400>  1
atcgccatct acagtttctg tctgttagag gagagtgtga aatctactgc gtcctagctc       60

tgtaccttgg acaaagtggg gcagtcaacg tccaaacccg aaaacctagc taagtctggg      120

ttttcgccac aacaaagaag ccaaccagag catggtcttg ggcttcaagt acta atg        177
                                                            Met           
                                                            1             

aac aac gat att aac tcg tcc gtg gaa agc ctt aac tca gct tgc aac        225
Asn Asn Asp Ile Asn Ser Ser Val Glu Ser Leu Asn Ser Ala Cys Asn           
            5                   10                  15                    

atg cag tct gat act gat act gca cca ctt ctt gag gat ggc cag cat        273
Met Gln Ser Asp Thr Asp Thr Ala Pro Leu Leu Glu Asp Gly Gln His           
        20                  25                  30                        

gcc agc aac cag gga gca gca tct agc tcc cgg gga cag cca cag gcg        321
Ala Ser Asn Gln Gly Ala Ala Ser Ser Ser Arg Gly Gln Pro Gln Ala           
    35                  40                  45                            

tcc ccg agg cag aaa atg caa cgc tcg cag cct gtg cac att ctc agg        369
Ser Pro Arg Gln Lys Met Gln Arg Ser Gln Pro Val His Ile Leu Arg           
50                  55                  60                  65            

cgc ctt cag gag gaa gac cag cag tta aga act gca tct ctt ccg gcc        417
Arg Leu Gln Glu Glu Asp Gln Gln Leu Arg Thr Ala Ser Leu Pro Ala           
                70                  75                  80                

atc ccc aac cca ttt ccg gag ctc act ggt gcg gcc cct ggg agc cct        465
Ile Pro Asn Pro Phe Pro Glu Leu Thr Gly Ala Ala Pro Gly Ser Pro           
            85                  90                  95                    

cct tcg gtt gct cct agc tcc tta cct cct cct ccg agc cag cca cct        513
Pro Ser Val Ala Pro Ser Ser Leu Pro Pro Pro Pro Ser Gln Pro Pro           
        100                 105                 110                       

gcc aag cat gat gtc aaa gtc ttt agt gaa gat ggg acc agc aaa gtg        561
Ala Lys His Asp Val Lys Val Phe Ser Glu Asp Gly Thr Ser Lys Val           
    115                 120                 125                           

gtg gag att cta acc gac atg aca gcc agg gac ctg tgc cag ctg ctg        609
Val Glu Ile Leu Thr Asp Met Thr Ala Arg Asp Leu Cys Gln Leu Leu           
130                 135                 140                 145           

gtt tac aaa agt cac tgt gtg gat gac aac agc tgg act ctg gtg gaa        657
Val Tyr Lys Ser His Cys Val Asp Asp Asn Ser Trp Thr Leu Val Glu           
                150                 155                 160               

cac cac cca caa ctg gga tta gag agg tgc ctg gag gac cat gag atc        705
His His Pro Gln Leu Gly Leu Glu Arg Cys Leu Glu Asp His Glu Ile           
            165                 170                 175                   

gtg gtc caa gtg gag agt acc atg cca agt gag agc aaa ttc tta ttc        753
Val Val Gln Val Glu Ser Thr Met Pro Ser Glu Ser Lys Phe Leu Phe           
        180                 185                 190                       

aga aag aat tat gcg aag tac gag ttc ttt aag aat cca gtg aac ttc        801
Arg Lys Asn Tyr Ala Lys Tyr Glu Phe Phe Lys Asn Pro Val Asn Phe           
    195                 200                 205                           

ttc ccg gat cag atg gtc aat tgg tgc cag cag tcc aac ggt ggc cag        849
Phe Pro Asp Gln Met Val Asn Trp Cys Gln Gln Ser Asn Gly Gly Gln           
210                 215                 220                 225           

gcg cag ctt ctg cag aat ttt ctg aac acc agc agc tgc cct gag atc        897
Ala Gln Leu Leu Gln Asn Phe Leu Asn Thr Ser Ser Cys Pro Glu Ile           
                230                 235                 240               

cag ggg ttc ttg cag gtg aaa gag gta gga cgc aag tct tgg aag aag        945
Gln Gly Phe Leu Gln Val Lys Glu Val Gly Arg Lys Ser Trp Lys Lys           
            245                 250                 255                   

ctg tat gtg tgc ctg cgc aga tct ggc ctc tat tac tcc acc aag ggg        993
Leu Tyr Val Cys Leu Arg Arg Ser Gly Leu Tyr Tyr Ser Thr Lys Gly           
        260                 265                 270                       

act tca aaa gaa ccc aga cac ctg cag ctg ctg gct gac ctg gaa gaa       1041
Thr Ser Lys Glu Pro Arg His Leu Gln Leu Leu Ala Asp Leu Glu Glu           
    275                 280                 285                           

agc agc atc ttc tac ctg att gct gga aag aag cag tac aac gcg ccg       1089
Ser Ser Ile Phe Tyr Leu Ile Ala Gly Lys Lys Gln Tyr Asn Ala Pro           
290                 295                 300                 305           

aat gaa cat ggg atg tgc atc aag cca aac aaa gcg aag acc gag atg       1137
Asn Glu His Gly Met Cys Ile Lys Pro Asn Lys Ala Lys Thr Glu Met           
                310                 315                 320               

aag gag ctt cgt ctg ctc tgt gcc gaa gat gag cag atc cgt act tgc       1185
Lys Glu Leu Arg Leu Leu Cys Ala Glu Asp Glu Gln Ile Arg Thr Cys           
            325                 330                 335                   

tgg atg act gcc ttc aga ctg ctc aag tac gga atg ctc ctg tac caa       1233
Trp Met Thr Ala Phe Arg Leu Leu Lys Tyr Gly Met Leu Leu Tyr Gln           
        340                 345                 350                       

aac tat cgc atc cca cag agg aag ggt ctg ccc cct cct ttc aac gca       1281
Asn Tyr Arg Ile Pro Gln Arg Lys Gly Leu Pro Pro Pro Phe Asn Ala           
    355                 360                 365                           

cct atg cgc agt gtt tct gag aat tct ctt gtg gcc atg gat ttt tct       1329
Pro Met Arg Ser Val Ser Glu Asn Ser Leu Val Ala Met Asp Phe Ser           
370                 375                 380                 385           

gga caa atc gga aga gtg atc gat aac ccg gct gaa gcc cag agt gct       1377
Gly Gln Ile Gly Arg Val Ile Asp Asn Pro Ala Glu Ala Gln Ser Ala           
                390                 395                 400               

gcc ctg gaa gag ggc cat gcc tgg cgt aag cgg agc aca cgg atg aat       1425
Ala Leu Glu Glu Gly His Ala Trp Arg Lys Arg Ser Thr Arg Met Asn           
            405                 410                 415                   

atc cta agc agc caa agc cca ctg cat cct tct acc ctg aat gca gtg       1473
Ile Leu Ser Ser Gln Ser Pro Leu His Pro Ser Thr Leu Asn Ala Val           
        420                 425                 430                       

att cac agg act cag cat tgg ttc cat gga cgt atc tcc cgc gag gag       1521
Ile His Arg Thr Gln His Trp Phe His Gly Arg Ile Ser Arg Glu Glu           
    435                 440                 445                           

tct cac agg atc atc aag caa caa ggt ctc gtg gac ggg ctg ttc ctc       1569
Ser His Arg Ile Ile Lys Gln Gln Gly Leu Val Asp Gly Leu Phe Leu           
450                 455                 460                 465           

ctt cgt gac agc cag agt aat cca aag gcg ttc gta ctg aca ctg tgc       1617
Leu Arg Asp Ser Gln Ser Asn Pro Lys Ala Phe Val Leu Thr Leu Cys           
                470                 475                 480               

cat cac cag aag att aaa aac ttc cag atc tta cct tgc gag gat gat       1665
His His Gln Lys Ile Lys Asn Phe Gln Ile Leu Pro Cys Glu Asp Asp           
            485                 490                 495                   

ggg cag acc ttc ttc act ctg gat gat ggg aac acc aag ttc tcc gat       1713
Gly Gln Thr Phe Phe Thr Leu Asp Asp Gly Asn Thr Lys Phe Ser Asp           
        500                 505                 510                       

ctg atc cag ctg gtc gac ttc tac cag ctc aac aaa ggt gtt ctg ccc       1761
Leu Ile Gln Leu Val Asp Phe Tyr Gln Leu Asn Lys Gly Val Leu Pro           
    515                 520                 525                           

tgc aag ctg aaa cac cac tgc atc cgc gtg gcc tta tga cctccttgcc        1810
Cys Lys Leu Lys His His Cys Ile Arg Val Ala Leu                           
530                 535                 540                               

cactcacaga ggctggaggc agcgacactg gaacggagaa gagagatctg catgagggtg     1870

agaacacaca cctactccca cccaaggact cagaacaaca tggctttttg atcggtacca     1930

accgacctac atcaattagt tattggactt cacaaagatt tgccgctgtg gatcaaacag     1990

gaccacctcc ctctgcgtca gccatttaaa attgggggag ggaagagatc cagtgcaagt     2050

gtgggaagaa actggaatga cgattttgat taggccacgt agggtgaaaa ccgcagaaaa     2110

atgattggaa atgaactctt gccctggaat aaccttgaca attcaaaccg cgatgtttac     2170

tttttgtatt gatcactttt ttgcactcct tcttcgttgt cgatgttgta ctcagcctat     2230

ggtaggagag gatgtggctt tgcaactcag atcagacaaa gaatttttga attggcaggc     2290

tttagcctac aaatgggtcc cccaagtttt ctagataaca tcctgctctc tgcaggttgc     2350

ggcagtgtgg gtttggctcc agtccttccc attatacttg aaaagctttt tttttttttt     2410

aaataaaata ataagataaa aggtgacaac cgcagttgac acctagcatg ttttgtggac     2470

gcagtcaagc tgccacagtc tggtcatcgt tgttgttgtg ctgacgtctg gtcatgtatt     2530

attagtgtgt ctcgttctcc acggtgctgg agacctcatt actttggaaa actcactgtt     2590

ccccagcaca gcacagctgc atgacctcag cttcagactg atgtcagcca gccttcttgg     2650

aacacattgc tattcattgt ggatgccaca cagtccatct ggggtgccct gtgcctccca     2710

ttttcacagc cgcccactgt tgtagaataa tcgctgcctt taccctctgc agtaccctca     2770

gtcatttcac ttctcccaca ggggtggggt aggggtgggg ttaaaggatc gaaagagaaa     2830

aaaacgccaa cttgttggcc ttgtgctctg tcactctgag catctatggt gataaagaga     2890

aggaaacgct gcagaggcac aagcataagc tggctttgag tctttgaaag cttgatggcc     2950

tctgcaccct actgaaaacc ccctaagcca gcaggagcag ggtatgcaga ggctttgcct     3010

ctgctggctt agggtgagaa gtacctcaca atggatgtga acattggaca gattttagga     3070

gcatgatgtt tgcctcctcc gagagagagg agtcagagag agagaggagt cagaaggtgg     3130

ccggagttat cattgggtcc cctgagctcc atgaaggacc ctctgttgtc cccttgatga     3190

tttatcaggc atgagagtag cagacaggat tgccttgaga aacacacaga caacaacggt     3250

ggtgaacaca tttccctttc ttgataccac ccagaaagtc tgctacatac ctgagttagc     3310

cactagattg cctgtcccga ctcattgaag tgctccccag ggagccactt ctgatttgcc     3370

atggttgaca gcatagtgga agatagatat gacagcgctt tgtaaagcag gccagtggca     3430

agctggccca cagtagagaa acactgtagt tcacagacca tgcaaccgtg tttccacgag     3490

atgttattac aacaaatgaa gaattttttt cctttttttt cattttaatc ttttttgact     3550

tttttttagt taaccatttt ttatgcataa gtgctcaaat gcatttctct ttctttcgaa     3610

actagttaat cgttaagttg acaatgagag aattctcaag ttcatacctg gcagcaggct     3670

cccactgatc ttccccttac agacagataa cagacatttc agttttaccg tgctcatttc     3730

tttttgctga cttaaggtca gaacttttac agacaacaaa caaccctagg gtttcttttt     3790

ccagtttaca cagaccggtc cccacagtgc agaatccatt tctctttcgt ctcaacagta     3850

gacaactagg atgtggatct catatttata agtatgcatt ttatttaaga ggaagtatag     3910

gcttgactct ggttcacaat ttcgtacgta gctggtttga cgtagaactt tgtacttccc     3970

ttgccgaagt gaattgttga aggctgcaac ccacccacct tgagtgtagc agacttcagt     4030

ggccccgaga tcgccagccc tttgcacagg cagctgggaa ttccacctga aacagctggt     4090

ccctaggtta gcgggttccc agccccccta atcagagact gaaggacaat tgacttttat     4150

ttttgtattt aattgacatg aatgtaaagg ggacagctca gggttgtttt ggagcctgtt     4210

tgactttgta atctctgcct gtgattttct tttctaaatg acgactccgt gtaaccacct     4270

ggactaagtt gagaaggaaa ctgccaaatg ctttgggttt ttagggtttt aataggtaga     4330

ctctgttcta ttattaggtg ttaagagttt ccaaacgtgt tttctttttt cttttattgt     4390

ttgcttaaac tttgaagaaa tatgtgcctc agcttagatg ttttgtcttc ccctttctgc     4450

acttaaatac ctgacagcct gttcgatcgc tgtgcctccg agggcgcttc tagctcatcg     4510

tagatttgtg atgtcatagt gcaaactgca gtgaccggta aaatgacctg acatgtaacc     4570

gttttcaggg aatgcagagg gtgttaacta atagacaaaa cctttatccc gcgtgctttg     4630

cttcaccttg tgctatatag ctctttggct cgtgaaccta attgtaaact ttcaggtatt     4690

tttgtacaaa taagggactg atgttctgtt tcttgttatt agaaataaac attaataaag     4750

cgttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                 4799


<210>  2
<211>  541
<212>  PRT
<213>  Mus musculus - Grb10

<400>  2

Met Asn Asn Asp Ile Asn Ser Ser Val Glu Ser Leu Asn Ser Ala Cys 
1               5                   10                  15      


Asn Met Gln Ser Asp Thr Asp Thr Ala Pro Leu Leu Glu Asp Gly Gln 
            20                  25                  30          


His Ala Ser Asn Gln Gly Ala Ala Ser Ser Ser Arg Gly Gln Pro Gln 
        35                  40                  45              


Ala Ser Pro Arg Gln Lys Met Gln Arg Ser Gln Pro Val His Ile Leu 
    50                  55                  60                  


Arg Arg Leu Gln Glu Glu Asp Gln Gln Leu Arg Thr Ala Ser Leu Pro 
65                  70                  75                  80  


Ala Ile Pro Asn Pro Phe Pro Glu Leu Thr Gly Ala Ala Pro Gly Ser 
                85                  90                  95      


Pro Pro Ser Val Ala Pro Ser Ser Leu Pro Pro Pro Pro Ser Gln Pro 
            100                 105                 110         


Pro Ala Lys His Asp Val Lys Val Phe Ser Glu Asp Gly Thr Ser Lys 
        115                 120                 125             


Val Val Glu Ile Leu Thr Asp Met Thr Ala Arg Asp Leu Cys Gln Leu 
    130                 135                 140                 


Leu Val Tyr Lys Ser His Cys Val Asp Asp Asn Ser Trp Thr Leu Val 
145                 150                 155                 160 


Glu His His Pro Gln Leu Gly Leu Glu Arg Cys Leu Glu Asp His Glu 
                165                 170                 175     


Ile Val Val Gln Val Glu Ser Thr Met Pro Ser Glu Ser Lys Phe Leu 
            180                 185                 190         


Phe Arg Lys Asn Tyr Ala Lys Tyr Glu Phe Phe Lys Asn Pro Val Asn 
        195                 200                 205             


Phe Phe Pro Asp Gln Met Val Asn Trp Cys Gln Gln Ser Asn Gly Gly 
    210                 215                 220                 


Gln Ala Gln Leu Leu Gln Asn Phe Leu Asn Thr Ser Ser Cys Pro Glu 
225                 230                 235                 240 


Ile Gln Gly Phe Leu Gln Val Lys Glu Val Gly Arg Lys Ser Trp Lys 
                245                 250                 255     


Lys Leu Tyr Val Cys Leu Arg Arg Ser Gly Leu Tyr Tyr Ser Thr Lys 
            260                 265                 270         


Gly Thr Ser Lys Glu Pro Arg His Leu Gln Leu Leu Ala Asp Leu Glu 
        275                 280                 285             


Glu Ser Ser Ile Phe Tyr Leu Ile Ala Gly Lys Lys Gln Tyr Asn Ala 
    290                 295                 300                 


Pro Asn Glu His Gly Met Cys Ile Lys Pro Asn Lys Ala Lys Thr Glu 
305                 310                 315                 320 


Met Lys Glu Leu Arg Leu Leu Cys Ala Glu Asp Glu Gln Ile Arg Thr 
                325                 330                 335     


Cys Trp Met Thr Ala Phe Arg Leu Leu Lys Tyr Gly Met Leu Leu Tyr 
            340                 345                 350         


Gln Asn Tyr Arg Ile Pro Gln Arg Lys Gly Leu Pro Pro Pro Phe Asn 
        355                 360                 365             


Ala Pro Met Arg Ser Val Ser Glu Asn Ser Leu Val Ala Met Asp Phe 
    370                 375                 380                 


Ser Gly Gln Ile Gly Arg Val Ile Asp Asn Pro Ala Glu Ala Gln Ser 
385                 390                 395                 400 


Ala Ala Leu Glu Glu Gly His Ala Trp Arg Lys Arg Ser Thr Arg Met 
                405                 410                 415     


Asn Ile Leu Ser Ser Gln Ser Pro Leu His Pro Ser Thr Leu Asn Ala 
            420                 425                 430         


Val Ile His Arg Thr Gln His Trp Phe His Gly Arg Ile Ser Arg Glu 
        435                 440                 445             


Glu Ser His Arg Ile Ile Lys Gln Gln Gly Leu Val Asp Gly Leu Phe 
    450                 455                 460                 


Leu Leu Arg Asp Ser Gln Ser Asn Pro Lys Ala Phe Val Leu Thr Leu 
465                 470                 475                 480 


Cys His His Gln Lys Ile Lys Asn Phe Gln Ile Leu Pro Cys Glu Asp 
                485                 490                 495     


Asp Gly Gln Thr Phe Phe Thr Leu Asp Asp Gly Asn Thr Lys Phe Ser 
            500                 505                 510         


Asp Leu Ile Gln Leu Val Asp Phe Tyr Gln Leu Asn Lys Gly Val Leu 
        515                 520                 525             


Pro Cys Lys Leu Lys His His Cys Ile Arg Val Ala Leu 
    530                 535                 540     


<210>  3
<211>  2312
<212>  DNA
<213>  Homo sapiens - Grb10


<220>
<221>  CDS
<222>  (310)..(1920)

<400>  3
gagccgcgcg cggcagcttt ggcgctgacc acaatgctga gcaggaagca gcagctgcag       60

gcccagtgac tggtagctca gtgaccagca gcccagtgac cggcagccag gtcctcacct      120

gggtcctctc agtgaagcca gggtggccgc cccagcagac agtgctacag agccaactcc      180

tgacaggaca aggtggagca gacacctcgc agtcaacaag acccggcagg accaggactc      240

cccgcacagt ctgaccgact tgcgaatcac caggaggatg atgtggacct ggaagccctg      300

gtgaacgat atg aat gca tcc ctg gag agc ctg tac tcg gcc tgc agc atg      351
          Met Asn Ala Ser Leu Glu Ser Leu Tyr Ser Ala Cys Ser Met         
          1               5                   10                          

cag tca gac acg gtg ccc ctc ctg cag aat ggc cag cat gcc cgc agc        399
Gln Ser Asp Thr Val Pro Leu Leu Gln Asn Gly Gln His Ala Arg Ser           
15                  20                  25                  30            

cag cct cgg gct tca ggc cct cct cgg tcc atc cag cca cag gtg tcc        447
Gln Pro Arg Ala Ser Gly Pro Pro Arg Ser Ile Gln Pro Gln Val Ser           
                35                  40                  45                

cca agg cag agg gtg cag cgc tcc cag cct gtg cac atc ctc gct gtc        495
Pro Arg Gln Arg Val Gln Arg Ser Gln Pro Val His Ile Leu Ala Val           
            50                  55                  60                    

agg cgc ctt cag gag gaa gac cag cag ttt aga acc tca tct ctg ccg        543
Arg Arg Leu Gln Glu Glu Asp Gln Gln Phe Arg Thr Ser Ser Leu Pro           
        65                  70                  75                        

gcc atc ccc aat cct ttt cct gaa ctc tgt ggc cct ggg agc ccc cct        591
Ala Ile Pro Asn Pro Phe Pro Glu Leu Cys Gly Pro Gly Ser Pro Pro           
    80                  85                  90                            

gtg ctc acg ccg ggt tct tta cct ccg agc cag gcc gcc gca aag cag        639
Val Leu Thr Pro Gly Ser Leu Pro Pro Ser Gln Ala Ala Ala Lys Gln           
95                  100                 105                 110           

gat gtt aaa gtc ttt agt gaa gat ggg aca agc aaa gtg gtg gag att        687
Asp Val Lys Val Phe Ser Glu Asp Gly Thr Ser Lys Val Val Glu Ile           
                115                 120                 125               

cta gca gac atg aca gcc aga gac ctg tgc caa ttg ctg gtt tac aaa        735
Leu Ala Asp Met Thr Ala Arg Asp Leu Cys Gln Leu Leu Val Tyr Lys           
            130                 135                 140                   

agt cac tgt gtg gat gac aac agc tgg aca cta gtg gag cac cac ccg        783
Ser His Cys Val Asp Asp Asn Ser Trp Thr Leu Val Glu His His Pro           
        145                 150                 155                       

cac cta gga tta gag agg tgc ttg gaa gac cat gag ctg gtg gtc cag        831
His Leu Gly Leu Glu Arg Cys Leu Glu Asp His Glu Leu Val Val Gln           
    160                 165                 170                           

gtg gag agt acc atg gcc agt gag agt aaa ttt cta ttc agg aag aat        879
Val Glu Ser Thr Met Ala Ser Glu Ser Lys Phe Leu Phe Arg Lys Asn           
175                 180                 185                 190           

tac gca aaa tac gag ttc ttt aaa aat ccc atg aat ttc ttc cca gaa        927
Tyr Ala Lys Tyr Glu Phe Phe Lys Asn Pro Met Asn Phe Phe Pro Glu           
                195                 200                 205               

cag atg gtt act tgg tgc cag cag tca aat ggc agt caa acc cag ctt        975
Gln Met Val Thr Trp Cys Gln Gln Ser Asn Gly Ser Gln Thr Gln Leu           
            210                 215                 220                   

ttg cag aat ttt ctg aac tcc agt agt tgt cct gaa att caa ggg ttt       1023
Leu Gln Asn Phe Leu Asn Ser Ser Ser Cys Pro Glu Ile Gln Gly Phe           
        225                 230                 235                       

ttg cat gtg aaa gag ctg gga aag aaa tca tgg aaa aag ctg tat gtg       1071
Leu His Val Lys Glu Leu Gly Lys Lys Ser Trp Lys Lys Leu Tyr Val           
    240                 245                 250                           

tgt ttg cgg aga tct ggc ctt tat tgc tcc acc aag gga act tca aag       1119
Cys Leu Arg Arg Ser Gly Leu Tyr Cys Ser Thr Lys Gly Thr Ser Lys           
255                 260                 265                 270           

gaa ccc aga cac ctg cag ctg ctg gcc gac ctg gag gac agc aac atc       1167
Glu Pro Arg His Leu Gln Leu Leu Ala Asp Leu Glu Asp Ser Asn Ile           
                275                 280                 285               

ttc tcc ctg atc gct ggc agg aag cag tac aac gcc cct aca gac cac       1215
Phe Ser Leu Ile Ala Gly Arg Lys Gln Tyr Asn Ala Pro Thr Asp His           
            290                 295                 300                   

ggg ctc tgc ata aag cca aac aaa gtc agg aat gaa act aaa gag ctg       1263
Gly Leu Cys Ile Lys Pro Asn Lys Val Arg Asn Glu Thr Lys Glu Leu           
        305                 310                 315                       

agg ttg ctc tgt gca gag gac gag caa acc agg acg tgc tgg atg aca       1311
Arg Leu Leu Cys Ala Glu Asp Glu Gln Thr Arg Thr Cys Trp Met Thr           
    320                 325                 330                           

gcg ttc aga ctc ctc aag tat gga atg ctc ctt tac cag aat tac cga       1359
Ala Phe Arg Leu Leu Lys Tyr Gly Met Leu Leu Tyr Gln Asn Tyr Arg           
335                 340                 345                 350           

atc cct cag cag agg aag gcc ttg ctg tcc ccg ttc tcg acg cca gtg       1407
Ile Pro Gln Gln Arg Lys Ala Leu Leu Ser Pro Phe Ser Thr Pro Val           
                355                 360                 365               

cgc agt gtc tcc gag aac tcc ctc gtg gca atg gat ttt tct ggg caa       1455
Arg Ser Val Ser Glu Asn Ser Leu Val Ala Met Asp Phe Ser Gly Gln           
            370                 375                 380                   

aca gga cgc gtg ata gag aat ccg gcg gag gcc cag agc gca gcc ctg       1503
Thr Gly Arg Val Ile Glu Asn Pro Ala Glu Ala Gln Ser Ala Ala Leu           
        385                 390                 395                       

gag gag ggc cac gcc tgg agg aag cga agc aca cgg atg aac atc cta       1551
Glu Glu Gly His Ala Trp Arg Lys Arg Ser Thr Arg Met Asn Ile Leu           
    400                 405                 410                           

ggt agc caa agt ccc ctc cac cct tct acc cta agt aca gtg att cac       1599
Gly Ser Gln Ser Pro Leu His Pro Ser Thr Leu Ser Thr Val Ile His           
415                 420                 425                 430           

agg aca cag cac tgg ttt cac ggg agg atc tcc agg gag gaa tcc cac       1647
Arg Thr Gln His Trp Phe His Gly Arg Ile Ser Arg Glu Glu Ser His           
                435                 440                 445               

agg atc att aaa cag caa ggg ctc gtg gat ggg ctt ttt ctc ctc cgt       1695
Arg Ile Ile Lys Gln Gln Gly Leu Val Asp Gly Leu Phe Leu Leu Arg           
            450                 455                 460                   

gac agc cag agt aat cca aag gca ttt gta ctc aca ctg tgt cat cac       1743
Asp Ser Gln Ser Asn Pro Lys Ala Phe Val Leu Thr Leu Cys His His           
        465                 470                 475                       

cag aaa att aaa aat ttc cag atc tta cct tgc gag gac gac ggg cag       1791
Gln Lys Ile Lys Asn Phe Gln Ile Leu Pro Cys Glu Asp Asp Gly Gln           
    480                 485                 490                           

acg ttc ttc agc cta gat gac ggg aac acc aaa ttc tct gac ctg atc       1839
Thr Phe Phe Ser Leu Asp Asp Gly Asn Thr Lys Phe Ser Asp Leu Ile           
495                 500                 505                 510           

cag ctg gtt gac ttt tac cag ctg aac aaa gga gtc ctg cct tgc aaa       1887
Gln Leu Val Asp Phe Tyr Gln Leu Asn Lys Gly Val Leu Pro Cys Lys           
                515                 520                 525               

ctc aag cac cac tgc atc cga gtg gcc tta tga ccgcagatgt cctctcggct     1940
Leu Lys His His Cys Ile Arg Val Ala Leu                                   
            530                 535                                       

gaagactgga ggaagtgaac actggagtga agaagcggtc tgtgcgttgg tgaagaacac     2000

acatcgattc tgcacctggg gacccagagc gagatgggtt tgttcggtgc cagccgacca     2060

agattgacta gtttgttgga cttaaacgac gatttgctgc tgtgaaccca gcagggtcgc     2120

ctccctctgc gtcggccaaa ttggggaggg catggaagat ccagcggaaa gttgaaaata     2180

aactggaatg atcatcttgg cttgggccgc ttaggaacaa gaaccggaga gaagtgattg     2240

gaaatgaact cttgccctgg aataatcttg acaattaaaa ctgatatgtt taaaaaaaaa     2300

aaaaaaaaaa aa                                                         2312


<210>  4
<211>  536
<212>  PRT
<213>  Homo sapiens - Grb10

<400>  4

Met Asn Ala Ser Leu Glu Ser Leu Tyr Ser Ala Cys Ser Met Gln Ser 
1               5                   10                  15      


Asp Thr Val Pro Leu Leu Gln Asn Gly Gln His Ala Arg Ser Gln Pro 
            20                  25                  30          


Arg Ala Ser Gly Pro Pro Arg Ser Ile Gln Pro Gln Val Ser Pro Arg 
        35                  40                  45              


Gln Arg Val Gln Arg Ser Gln Pro Val His Ile Leu Ala Val Arg Arg 
    50                  55                  60                  


Leu Gln Glu Glu Asp Gln Gln Phe Arg Thr Ser Ser Leu Pro Ala Ile 
65                  70                  75                  80  


Pro Asn Pro Phe Pro Glu Leu Cys Gly Pro Gly Ser Pro Pro Val Leu 
                85                  90                  95      


Thr Pro Gly Ser Leu Pro Pro Ser Gln Ala Ala Ala Lys Gln Asp Val 
            100                 105                 110         


Lys Val Phe Ser Glu Asp Gly Thr Ser Lys Val Val Glu Ile Leu Ala 
        115                 120                 125             


Asp Met Thr Ala Arg Asp Leu Cys Gln Leu Leu Val Tyr Lys Ser His 
    130                 135                 140                 


Cys Val Asp Asp Asn Ser Trp Thr Leu Val Glu His His Pro His Leu 
145                 150                 155                 160 


Gly Leu Glu Arg Cys Leu Glu Asp His Glu Leu Val Val Gln Val Glu 
                165                 170                 175     


Ser Thr Met Ala Ser Glu Ser Lys Phe Leu Phe Arg Lys Asn Tyr Ala 
            180                 185                 190         


Lys Tyr Glu Phe Phe Lys Asn Pro Met Asn Phe Phe Pro Glu Gln Met 
        195                 200                 205             


Val Thr Trp Cys Gln Gln Ser Asn Gly Ser Gln Thr Gln Leu Leu Gln 
    210                 215                 220                 


Asn Phe Leu Asn Ser Ser Ser Cys Pro Glu Ile Gln Gly Phe Leu His 
225                 230                 235                 240 


Val Lys Glu Leu Gly Lys Lys Ser Trp Lys Lys Leu Tyr Val Cys Leu 
                245                 250                 255     


Arg Arg Ser Gly Leu Tyr Cys Ser Thr Lys Gly Thr Ser Lys Glu Pro 
            260                 265                 270         


Arg His Leu Gln Leu Leu Ala Asp Leu Glu Asp Ser Asn Ile Phe Ser 
        275                 280                 285             


Leu Ile Ala Gly Arg Lys Gln Tyr Asn Ala Pro Thr Asp His Gly Leu 
    290                 295                 300                 


Cys Ile Lys Pro Asn Lys Val Arg Asn Glu Thr Lys Glu Leu Arg Leu 
305                 310                 315                 320 


Leu Cys Ala Glu Asp Glu Gln Thr Arg Thr Cys Trp Met Thr Ala Phe 
                325                 330                 335     


Arg Leu Leu Lys Tyr Gly Met Leu Leu Tyr Gln Asn Tyr Arg Ile Pro 
            340                 345                 350         


Gln Gln Arg Lys Ala Leu Leu Ser Pro Phe Ser Thr Pro Val Arg Ser 
        355                 360                 365             


Val Ser Glu Asn Ser Leu Val Ala Met Asp Phe Ser Gly Gln Thr Gly 
    370                 375                 380                 


Arg Val Ile Glu Asn Pro Ala Glu Ala Gln Ser Ala Ala Leu Glu Glu 
385                 390                 395                 400 


Gly His Ala Trp Arg Lys Arg Ser Thr Arg Met Asn Ile Leu Gly Ser 
                405                 410                 415     


Gln Ser Pro Leu His Pro Ser Thr Leu Ser Thr Val Ile His Arg Thr 
            420                 425                 430         


Gln His Trp Phe His Gly Arg Ile Ser Arg Glu Glu Ser His Arg Ile 
        435                 440                 445             


Ile Lys Gln Gln Gly Leu Val Asp Gly Leu Phe Leu Leu Arg Asp Ser 
    450                 455                 460                 


Gln Ser Asn Pro Lys Ala Phe Val Leu Thr Leu Cys His His Gln Lys 
465                 470                 475                 480 


Ile Lys Asn Phe Gln Ile Leu Pro Cys Glu Asp Asp Gly Gln Thr Phe 
                485                 490                 495     


Phe Ser Leu Asp Asp Gly Asn Thr Lys Phe Ser Asp Leu Ile Gln Leu 
            500                 505                 510         


Val Asp Phe Tyr Gln Leu Asn Lys Gly Val Leu Pro Cys Lys Leu Lys 
        515                 520                 525             


His His Cys Ile Arg Val Ala Leu 
    530                 535     


<210>  5
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic PCR primer - Grb10 forward

<400>  5
cgtggtccag tggagagta                                                    19


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic PCR primer - Grb10 backward

<400>  6
tccggtcttc ggcgtaactg a                                                 21


<210>  7
<211>  1360
<212>  DNA
<213>  Mus musculus - Tripartite motif-containing 13


<220>
<221>  CDS
<222>  (94)..(1317)

<400>  7
ccgtcaaaac gtgagggaaa acgaactggc tctctccaca gaaaatatag taagcttgcc       60

aaaagcatat acttgcctgg aacaaaggat gta atg gag ctg ctt gaa gaa gac       114
                                     Met Glu Leu Leu Glu Glu Asp          
                                     1               5                    

ctc aca tgc cca att tgc tgc agt ttg ttt gat gac ccc cga gtg ttg        162
Leu Thr Cys Pro Ile Cys Cys Ser Leu Phe Asp Asp Pro Arg Val Leu           
        10                  15                  20                        

ccc tgc tca cac aac ttc tgc aaa aaa tgc tta gaa ggg ctc tta gag        210
Pro Cys Ser His Asn Phe Cys Lys Lys Cys Leu Glu Gly Leu Leu Glu           
    25                  30                  35                            

ggg aat gtg cgg aat tcc ctg tgg aga cca tct ccc ttc aag tgt cct        258
Gly Asn Val Arg Asn Ser Leu Trp Arg Pro Ser Pro Phe Lys Cys Pro           
40                  45                  50                  55            

acc tgc cgt aag gaa acc tca gct act gga gtc aac agt ctg cag gtc        306
Thr Cys Arg Lys Glu Thr Ser Ala Thr Gly Val Asn Ser Leu Gln Val           
                60                  65                  70                

aat tac tcc cta aag ggt atc gtg gag aaa tac aac aaa atc aag att        354
Asn Tyr Ser Leu Lys Gly Ile Val Glu Lys Tyr Asn Lys Ile Lys Ile           
            75                  80                  85                    

tct ccc aag atg cca gtg tgc aaa gga cat ttg ggg cag cct ctc aac        402
Ser Pro Lys Met Pro Val Cys Lys Gly His Leu Gly Gln Pro Leu Asn           
        90                  95                  100                       

atc ttc tgc gta act gat atg cag ctg att tgt ggg atc tgt gct act        450
Ile Phe Cys Val Thr Asp Met Gln Leu Ile Cys Gly Ile Cys Ala Thr           
    105                 110                 115                           

cga ggc gag cac acc aag cat gtc ttc tct tct att gaa gat gcc tac        498
Arg Gly Glu His Thr Lys His Val Phe Ser Ser Ile Glu Asp Ala Tyr           
120                 125                 130                 135           

gct cga gaa aag aat gcc ttt gag tcc ctc ttt cag agt ttc gag act        546
Ala Arg Glu Lys Asn Ala Phe Glu Ser Leu Phe Gln Ser Phe Glu Thr           
                140                 145                 150               

tgg cgc cgg gga gat gct ctt tcc cgc ttg gat act ttg gaa aca aac        594
Trp Arg Arg Gly Asp Ala Leu Ser Arg Leu Asp Thr Leu Glu Thr Asn           
            155                 160                 165                   

aag agg aaa gcc ctc cag tta ctc acg aag gat tca gat aaa gta aag        642
Lys Arg Lys Ala Leu Gln Leu Leu Thr Lys Asp Ser Asp Lys Val Lys           
        170                 175                 180                       

gag ttt ttt gag aag tta cag cac acc ttg gat caa aag aag aat gaa        690
Glu Phe Phe Glu Lys Leu Gln His Thr Leu Asp Gln Lys Lys Asn Glu           
    185                 190                 195                           

atc ctg tct gac ttt gaa act atg aag ctt gca gtt atg caa acc tat        738
Ile Leu Ser Asp Phe Glu Thr Met Lys Leu Ala Val Met Gln Thr Tyr           
200                 205                 210                 215           

gac ccg gag atc aac aaa atc aac act att tta cag gag cag cgg atg        786
Asp Pro Glu Ile Asn Lys Ile Asn Thr Ile Leu Gln Glu Gln Arg Met           
                220                 225                 230               

gcc ttc aac att gct gag gct ttc aaa gat gtc tca gaa cct att ata        834
Ala Phe Asn Ile Ala Glu Ala Phe Lys Asp Val Ser Glu Pro Ile Ile           
            235                 240                 245                   

ttt ttg caa cag atg caa gag ttc agg gag aaa atc aaa gta atc aag        882
Phe Leu Gln Gln Met Gln Glu Phe Arg Glu Lys Ile Lys Val Ile Lys           
        250                 255                 260                       

gaa act cct ttg cca cac tct aat ttg ccc aca agc cct tta atg aag        930
Glu Thr Pro Leu Pro His Ser Asn Leu Pro Thr Ser Pro Leu Met Lys           
    265                 270                 275                           

aac ttt gat acc agt cag tgg gga gac att aaa cta gtt gat gtg gat        978
Asn Phe Asp Thr Ser Gln Trp Gly Asp Ile Lys Leu Val Asp Val Asp           
280                 285                 290                 295           

aaa ctg tct ttg ccg caa gac aca ggt gtg ttc act agc aag att ccc       1026
Lys Leu Ser Leu Pro Gln Asp Thr Gly Val Phe Thr Ser Lys Ile Pro           
                300                 305                 310               

tgg tac ccc tat ctg ctg ctc atg atg gta gtt ctg ctg ggt ctc ctc       1074
Trp Tyr Pro Tyr Leu Leu Leu Met Met Val Val Leu Leu Gly Leu Leu           
            315                 320                 325                   

ata ttc ttt ggc ccc act gta ttc ctg gaa tgg tct cca ctt gat gaa       1122
Ile Phe Phe Gly Pro Thr Val Phe Leu Glu Trp Ser Pro Leu Asp Glu           
        330                 335                 340                       

ttg gca act tgg aaa gac tat ctt tca agc ttc aat tct tac ctg act       1170
Leu Ala Thr Trp Lys Asp Tyr Leu Ser Ser Phe Asn Ser Tyr Leu Thr           
    345                 350                 355                           

aag tct gct gat ttt ata gaa caa tct gtt ttt tac tgg gaa cag atg       1218
Lys Ser Ala Asp Phe Ile Glu Gln Ser Val Phe Tyr Trp Glu Gln Met           
360                 365                 370                 375           

aca gat ggg ttt ttc att ttt ggt gaa aga gta aaa aat gtt agt ttg       1266
Thr Asp Gly Phe Phe Ile Phe Gly Glu Arg Val Lys Asn Val Ser Leu           
                380                 385                 390               

gtg gca ctg aac aat gtg gca gag ttt ata tgc aaa tac aaa cta tta       1314
Val Ala Leu Asn Asn Val Ala Glu Phe Ile Cys Lys Tyr Lys Leu Leu           
            395                 400                 405                   

taa agtctttcaa ttacacagtt ctgcttcttg atgggattgt tgg                   1360


<210>  8
<211>  407
<212>  PRT
<213>  Mus musculus - Tripartite motif-containing 13

<400>  8

Met Glu Leu Leu Glu Glu Asp Leu Thr Cys Pro Ile Cys Cys Ser Leu 
1               5                   10                  15      


Phe Asp Asp Pro Arg Val Leu Pro Cys Ser His Asn Phe Cys Lys Lys 
            20                  25                  30          


Cys Leu Glu Gly Leu Leu Glu Gly Asn Val Arg Asn Ser Leu Trp Arg 
        35                  40                  45              


Pro Ser Pro Phe Lys Cys Pro Thr Cys Arg Lys Glu Thr Ser Ala Thr 
    50                  55                  60                  


Gly Val Asn Ser Leu Gln Val Asn Tyr Ser Leu Lys Gly Ile Val Glu 
65                  70                  75                  80  


Lys Tyr Asn Lys Ile Lys Ile Ser Pro Lys Met Pro Val Cys Lys Gly 
                85                  90                  95      


His Leu Gly Gln Pro Leu Asn Ile Phe Cys Val Thr Asp Met Gln Leu 
            100                 105                 110         


Ile Cys Gly Ile Cys Ala Thr Arg Gly Glu His Thr Lys His Val Phe 
        115                 120                 125             


Ser Ser Ile Glu Asp Ala Tyr Ala Arg Glu Lys Asn Ala Phe Glu Ser 
    130                 135                 140                 


Leu Phe Gln Ser Phe Glu Thr Trp Arg Arg Gly Asp Ala Leu Ser Arg 
145                 150                 155                 160 


Leu Asp Thr Leu Glu Thr Asn Lys Arg Lys Ala Leu Gln Leu Leu Thr 
                165                 170                 175     


Lys Asp Ser Asp Lys Val Lys Glu Phe Phe Glu Lys Leu Gln His Thr 
            180                 185                 190         


Leu Asp Gln Lys Lys Asn Glu Ile Leu Ser Asp Phe Glu Thr Met Lys 
        195                 200                 205             


Leu Ala Val Met Gln Thr Tyr Asp Pro Glu Ile Asn Lys Ile Asn Thr 
    210                 215                 220                 


Ile Leu Gln Glu Gln Arg Met Ala Phe Asn Ile Ala Glu Ala Phe Lys 
225                 230                 235                 240 


Asp Val Ser Glu Pro Ile Ile Phe Leu Gln Gln Met Gln Glu Phe Arg 
                245                 250                 255     


Glu Lys Ile Lys Val Ile Lys Glu Thr Pro Leu Pro His Ser Asn Leu 
            260                 265                 270         


Pro Thr Ser Pro Leu Met Lys Asn Phe Asp Thr Ser Gln Trp Gly Asp 
        275                 280                 285             


Ile Lys Leu Val Asp Val Asp Lys Leu Ser Leu Pro Gln Asp Thr Gly 
    290                 295                 300                 


Val Phe Thr Ser Lys Ile Pro Trp Tyr Pro Tyr Leu Leu Leu Met Met 
305                 310                 315                 320 


Val Val Leu Leu Gly Leu Leu Ile Phe Phe Gly Pro Thr Val Phe Leu 
                325                 330                 335     


Glu Trp Ser Pro Leu Asp Glu Leu Ala Thr Trp Lys Asp Tyr Leu Ser 
            340                 345                 350         


Ser Phe Asn Ser Tyr Leu Thr Lys Ser Ala Asp Phe Ile Glu Gln Ser 
        355                 360                 365             


Val Phe Tyr Trp Glu Gln Met Thr Asp Gly Phe Phe Ile Phe Gly Glu 
    370                 375                 380                 


Arg Val Lys Asn Val Ser Leu Val Ala Leu Asn Asn Val Ala Glu Phe 
385                 390                 395                 400 


Ile Cys Lys Tyr Lys Leu Leu 
                405         


<210>  9
<211>  1975
<212>  DNA
<213>  Homo sapiens - Tripartite motif-containing 13


<220>
<221>  CDS
<222>  (706)..(1929)

<400>  9
ggcgcgtacc gtgcggtccc tgtagttgga ggacgggcgg tcgcgcggcc tttcccacta       60

gccggaggtc ggagataagt acccgccgcc cggctcctct cgggaaagcg gggtggtcct      120

cgaaccttca gcgagggtgg ggagttgccc aggtcagcag ggatctgcgt gggttggggg      180

ggctggcgaa ggccgtctga gctccagtcc ggcagcgcgg cagaaaccag cggggcactg      240

tcatgggcct ggggaggagc ggcctgcgga gggcgccggg gcagtgtgtc tgtggtccag      300

aaaacctgct ccgtccggag ccttcctggc cccgctacca gcgtctccac atcccctaga      360

aaagaaaaga cgggtgtggg ccttaggtta cagcgcgccg ccagcgtttg gttgcatggc      420

gccgggggag ggcgccctaa ccgagaagct gcttaataca aagagctcca ggctcctggc      480

ggttcaccag gtctaaacag ccgggcttta tttgtggggg cgattgaaaa aattgagggt      540

caagattggg gtgctgtgca aataaatgcg ttaatactgt tctttttctt ctttctttgc      600

agtagcctct agttcgttag tcaaaacgtg aaaaaaaaga cctgctttgc cctgggaaat      660

agtaaccctg ccaaatacat cagcttgtag gagacagagg atgtg atg gag ctg ctt      717
                                                  Met Glu Leu Leu         
                                                  1                       

gaa gaa gat ctc aca tgc cct att tgt tgt agt ctg ttt gat gat cca        765
Glu Glu Asp Leu Thr Cys Pro Ile Cys Cys Ser Leu Phe Asp Asp Pro           
5                   10                  15                  20            

cgg gtt ttg cct tgc tcc cac aac ttc tgc aaa aaa tgc tta gaa ggt        813
Arg Val Leu Pro Cys Ser His Asn Phe Cys Lys Lys Cys Leu Glu Gly           
                25                  30                  35                

atc tta gaa ggg agt gtg cgg aat tcc ttg tgg aga cca gct cca ttc        861
Ile Leu Glu Gly Ser Val Arg Asn Ser Leu Trp Arg Pro Ala Pro Phe           
            40                  45                  50                    

aag tgt cct aca tgc cgt aag gaa act tca gct act gga att aat agc        909
Lys Cys Pro Thr Cys Arg Lys Glu Thr Ser Ala Thr Gly Ile Asn Ser           
        55                  60                  65                        

ctg cag gtt aat tac tcc ctg aag ggt att gtg gaa aag tat aac aag        957
Leu Gln Val Asn Tyr Ser Leu Lys Gly Ile Val Glu Lys Tyr Asn Lys           
    70                  75                  80                            

atc aag atc tct ccc aaa atg cca gta tgc aaa gga cac ttg ggg cag       1005
Ile Lys Ile Ser Pro Lys Met Pro Val Cys Lys Gly His Leu Gly Gln           
85                  90                  95                  100           

cct ctc aac att ttc tgc ctg act gat atg cag ctg att tgt ggg atc       1053
Pro Leu Asn Ile Phe Cys Leu Thr Asp Met Gln Leu Ile Cys Gly Ile           
                105                 110                 115               

tgt gct act cgt ggg gag cac acc aaa cat gtc ttc tgt tct att gaa       1101
Cys Ala Thr Arg Gly Glu His Thr Lys His Val Phe Cys Ser Ile Glu           
            120                 125                 130                   

gat gcc tat gct cag gaa agg gat gcc ttt gag tcc ctc ttc cag agc       1149
Asp Ala Tyr Ala Gln Glu Arg Asp Ala Phe Glu Ser Leu Phe Gln Ser           
        135                 140                 145                       

ttt gag acc tgg cgt cgg gga gat gct ctt tct cgc ttg gat acc ttg       1197
Phe Glu Thr Trp Arg Arg Gly Asp Ala Leu Ser Arg Leu Asp Thr Leu           
    150                 155                 160                           

gaa act agt aag agg aaa tcc cta cag tta ctg act aaa gat tca gat       1245
Glu Thr Ser Lys Arg Lys Ser Leu Gln Leu Leu Thr Lys Asp Ser Asp           
165                 170                 175                 180           

aaa gtg aag gaa ttt ttt gag aag tta caa cac aca ctg gat caa aag       1293
Lys Val Lys Glu Phe Phe Glu Lys Leu Gln His Thr Leu Asp Gln Lys           
                185                 190                 195               

aag aat gaa att ctg tct gac ttt gag acc atg aaa ctt gct gtt atg       1341
Lys Asn Glu Ile Leu Ser Asp Phe Glu Thr Met Lys Leu Ala Val Met           
            200                 205                 210                   

caa gca tat gac cca gag atc aac aaa ctc aac acc atc ttg cag gag       1389
Gln Ala Tyr Asp Pro Glu Ile Asn Lys Leu Asn Thr Ile Leu Gln Glu           
        215                 220                 225                       

caa cgg atg gcc ttt aac att gct gag gct ttc aaa gat gtg tca gaa       1437
Gln Arg Met Ala Phe Asn Ile Ala Glu Ala Phe Lys Asp Val Ser Glu           
    230                 235                 240                           

ccc att gta ttt ctg caa cag atg cag gag ttt aga gag aaa atc aaa       1485
Pro Ile Val Phe Leu Gln Gln Met Gln Glu Phe Arg Glu Lys Ile Lys           
245                 250                 255                 260           

gta atc aag gaa act cct tta cct ccc tct aat ttg cct gca agc cct       1533
Val Ile Lys Glu Thr Pro Leu Pro Pro Ser Asn Leu Pro Ala Ser Pro           
                265                 270                 275               

tta atg aag aac ttt gat acc agt cag tgg gaa gac ata aaa cta gtc       1581
Leu Met Lys Asn Phe Asp Thr Ser Gln Trp Glu Asp Ile Lys Leu Val           
            280                 285                 290                   

gat gtg gat aaa ctt tct ttg cct caa gac act ggc aca ttc att agc       1629
Asp Val Asp Lys Leu Ser Leu Pro Gln Asp Thr Gly Thr Phe Ile Ser           
        295                 300                 305                       

aag att ccc tgg agc ttt tat aag tta ttt ttg cta atc ctt ctg ctt       1677
Lys Ile Pro Trp Ser Phe Tyr Lys Leu Phe Leu Leu Ile Leu Leu Leu           
    310                 315                 320                           

ggc ctt gtc att gtc ttt ggt cct acc atg ttc cta gaa tgg tca tta       1725
Gly Leu Val Ile Val Phe Gly Pro Thr Met Phe Leu Glu Trp Ser Leu           
325                 330                 335                 340           

ttt gat gac ctg gca act tgg aaa ggc tgt ctt tca aac ttc agt tcc       1773
Phe Asp Asp Leu Ala Thr Trp Lys Gly Cys Leu Ser Asn Phe Ser Ser           
                345                 350                 355               

tat ctg act aaa aca gcc gat ttc ata gaa caa tca gtt ttt tac tgg       1821
Tyr Leu Thr Lys Thr Ala Asp Phe Ile Glu Gln Ser Val Phe Tyr Trp           
            360                 365                 370                   

gaa cag gtg aca gat ggg ttt ttc att ttc aat gaa aga ttc aag aat       1869
Glu Gln Val Thr Asp Gly Phe Phe Ile Phe Asn Glu Arg Phe Lys Asn           
        375                 380                 385                       

ttt act ttg gtg gta ctg aac aat gtg gca gaa ttt gtg tgc aaa tat       1917
Phe Thr Leu Val Val Leu Asn Asn Val Ala Glu Phe Val Cys Lys Tyr           
    390                 395                 400                           

aaa cta tta taa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa           1969
Lys Leu Leu                                                               
405                                                                       

aaaaaa                                                                1975


<210>  10
<211>  407
<212>  PRT
<213>  Homo sapiens - Tripartite motif-containing 13

<400>  10

Met Glu Leu Leu Glu Glu Asp Leu Thr Cys Pro Ile Cys Cys Ser Leu 
1               5                   10                  15      


Phe Asp Asp Pro Arg Val Leu Pro Cys Ser His Asn Phe Cys Lys Lys 
            20                  25                  30          


Cys Leu Glu Gly Ile Leu Glu Gly Ser Val Arg Asn Ser Leu Trp Arg 
        35                  40                  45              


Pro Ala Pro Phe Lys Cys Pro Thr Cys Arg Lys Glu Thr Ser Ala Thr 
    50                  55                  60                  


Gly Ile Asn Ser Leu Gln Val Asn Tyr Ser Leu Lys Gly Ile Val Glu 
65                  70                  75                  80  


Lys Tyr Asn Lys Ile Lys Ile Ser Pro Lys Met Pro Val Cys Lys Gly 
                85                  90                  95      


His Leu Gly Gln Pro Leu Asn Ile Phe Cys Leu Thr Asp Met Gln Leu 
            100                 105                 110         


Ile Cys Gly Ile Cys Ala Thr Arg Gly Glu His Thr Lys His Val Phe 
        115                 120                 125             


Cys Ser Ile Glu Asp Ala Tyr Ala Gln Glu Arg Asp Ala Phe Glu Ser 
    130                 135                 140                 


Leu Phe Gln Ser Phe Glu Thr Trp Arg Arg Gly Asp Ala Leu Ser Arg 
145                 150                 155                 160 


Leu Asp Thr Leu Glu Thr Ser Lys Arg Lys Ser Leu Gln Leu Leu Thr 
                165                 170                 175     


Lys Asp Ser Asp Lys Val Lys Glu Phe Phe Glu Lys Leu Gln His Thr 
            180                 185                 190         


Leu Asp Gln Lys Lys Asn Glu Ile Leu Ser Asp Phe Glu Thr Met Lys 
        195                 200                 205             


Leu Ala Val Met Gln Ala Tyr Asp Pro Glu Ile Asn Lys Leu Asn Thr 
    210                 215                 220                 


Ile Leu Gln Glu Gln Arg Met Ala Phe Asn Ile Ala Glu Ala Phe Lys 
225                 230                 235                 240 


Asp Val Ser Glu Pro Ile Val Phe Leu Gln Gln Met Gln Glu Phe Arg 
                245                 250                 255     


Glu Lys Ile Lys Val Ile Lys Glu Thr Pro Leu Pro Pro Ser Asn Leu 
            260                 265                 270         


Pro Ala Ser Pro Leu Met Lys Asn Phe Asp Thr Ser Gln Trp Glu Asp 
        275                 280                 285             


Ile Lys Leu Val Asp Val Asp Lys Leu Ser Leu Pro Gln Asp Thr Gly 
    290                 295                 300                 


Thr Phe Ile Ser Lys Ile Pro Trp Ser Phe Tyr Lys Leu Phe Leu Leu 
305                 310                 315                 320 


Ile Leu Leu Leu Gly Leu Val Ile Val Phe Gly Pro Thr Met Phe Leu 
                325                 330                 335     


Glu Trp Ser Leu Phe Asp Asp Leu Ala Thr Trp Lys Gly Cys Leu Ser 
            340                 345                 350         


Asn Phe Ser Ser Tyr Leu Thr Lys Thr Ala Asp Phe Ile Glu Gln Ser 
        355                 360                 365             


Val Phe Tyr Trp Glu Gln Val Thr Asp Gly Phe Phe Ile Phe Asn Glu 
    370                 375                 380                 


Arg Phe Lys Asn Phe Thr Leu Val Val Leu Asn Asn Val Ala Glu Phe 
385                 390                 395                 400 


Val Cys Lys Tyr Lys Leu Leu 
                405         


<210>  11
<211>  555
<212>  DNA
<213>  Mus musculus - Serum amyloid A3


<220>
<221>  CDS
<222>  (35)..(403)

<400>  11
tggggtccca gcaggagctc gcagcacgag cagg atg aag cct tcc att gcc atc       55
                                      Met Lys Pro Ser Ile Ala Ile         
                                      1               5                   

att ctt tgc atc ttg atc ctg gga gtt gac agc caa aga tgg gtc cag        103
Ile Leu Cys Ile Leu Ile Leu Gly Val Asp Ser Gln Arg Trp Val Gln           
        10                  15                  20                        

ttc atg aaa gaa gct ggt caa ggg tct aga gac atg tgg cga gcc tac        151
Phe Met Lys Glu Ala Gly Gln Gly Ser Arg Asp Met Trp Arg Ala Tyr           
    25                  30                  35                            

tct gac atg aag aaa gct aac tgg aaa aac tca gac aaa tac ttc cat        199
Ser Asp Met Lys Lys Ala Asn Trp Lys Asn Ser Asp Lys Tyr Phe His           
40                  45                  50                  55            

gct cgg ggg aac tat gat gct gcc cgg agg ggt ccc ggg gga gcc tgg        247
Ala Arg Gly Asn Tyr Asp Ala Ala Arg Arg Gly Pro Gly Gly Ala Trp           
                60                  65                  70                

gct gct aaa gtc atc agt gat gcc aga gag gct gtt cag aag ttc acg        295
Ala Ala Lys Val Ile Ser Asp Ala Arg Glu Ala Val Gln Lys Phe Thr           
            75                  80                  85                    

gga cat gga gca gag gac tca aga gct gac cag ttt gcc aac gag tgg        343
Gly His Gly Ala Glu Asp Ser Arg Ala Asp Gln Phe Ala Asn Glu Trp           
        90                  95                  100                       

ggc cgg agt ggc aaa gac ccc aac cac ttc cga cct gct ggc ctg cct        391
Gly Arg Ser Gly Lys Asp Pro Asn His Phe Arg Pro Ala Gly Leu Pro           
    105                 110                 115                           

aaa aga tac tga gttttctctt cctgttgttc cctgtcatgc tgccccccga            443
Lys Arg Tyr                                                               
120                                                                       

gaagaggggc aactactggg ttgagatatt ttctaaaatc tggatcccta aacatcccaa      503

tgtgctgaat aaatacttgt gaaatgcaaa aaaaaaaaaa aaaaaaaaaa aa              555


<210>  12
<211>  122
<212>  PRT
<213>  Mus musculus - Serum amyloid A3

<400>  12

Met Lys Pro Ser Ile Ala Ile Ile Leu Cys Ile Leu Ile Leu Gly Val 
1               5                   10                  15      


Asp Ser Gln Arg Trp Val Gln Phe Met Lys Glu Ala Gly Gln Gly Ser 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Lys Lys Ala Asn Trp Lys 
        35                  40                  45              


Asn Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Arg 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Lys Val Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Ala Val Gln Lys Phe Thr Gly His Gly Ala Glu Asp Ser Arg Ala 
                85                  90                  95      


Asp Gln Phe Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Lys Arg Tyr 
        115                 120         


<210>  13
<211>  716
<212>  DNA
<213>  Homo sapiens - Serum amyloid A1


<220>
<221>  CDS
<222>  (224)..(592)

<400>  13
aggctcagta taaatagcag ccaccgctcc ctggcaggca gggacccgca gctcagctac       60

agcacagatc aggtgaggag cacaccaagg agtgattttt aaaacttact ctgttttctc      120

tttcccaaca agattatcat ttcctttaaa aaaaatagtt atcctggggc atacagccat      180

accattctga aggtgtctta tctcctctga tctagagagc acc atg aag ctt ctc        235
                                                Met Lys Leu Leu           
                                                1                         

acg ggc ctg gtt ttc tgc tcc ttg gtc ctg ggt gtc agc agc cga agc        283
Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val Ser Ser Arg Ser           
5                   10                  15                  20            

ttc ttt tcg ttc ctt ggc gag gct ttt gat ggg gct cgg gac atg tgg        331
Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg Asp Met Trp           
                25                  30                  35                

aga gcc tac tct gac atg aga gaa gcc aat tac atc ggc tca gac aaa        379
Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile Gly Ser Asp Lys           
            40                  45                  50                    

tac ttc cat gct cgg ggg aac tat gat gct gcc aaa agg gga cct ggg        427
Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys Arg Gly Pro Gly           
        55                  60                  65                        

ggt gcc tgg gct gca gaa gtg atc agc gat gcc aga gag aat atc cag        475
Gly Ala Trp Ala Ala Glu Val Ile Ser Asp Ala Arg Glu Asn Ile Gln           
    70                  75                  80                            

aga ttc ttt ggc cat ggt gcg gag gac tcg ctg gct gat cag gct gcc        523
Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala Asp Gln Ala Ala           
85                  90                  95                  100           

aat gaa tgg ggc agg agt ggc aaa gac ccc aat cac ttc cga cct gct        571
Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His Phe Arg Pro Ala           
                105                 110                 115               

ggc ctg cct gag aaa tac tga gcttcctctt cactctgctc tcaggagatc           622
Gly Leu Pro Glu Lys Tyr                                                   
            120                                                           

tggctgtgag gccctcaggg cagggataca aagcggggag agggtacaca atgggtatct      682

aataaatact taagaggtgg aatttgtgga aact                                  716


<210>  14
<211>  122
<212>  PRT
<213>  Homo sapiens - Serum amyloid A1

<400>  14

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  15
<211>  924
<212>  DNA
<213>  Mus musculus - Xlr-related, meiosis regulated Xmr


<220>
<221>  CDS
<222>  (164)..(802)

<400>  15
caggaatctc tgctgacaac ggttttttac cattgaggag ttgagcacgg aagggtgcag       60

ttgtgaaggt gttcacctct gagataacct ttaagtgata atcggctctg ctcagggttg      120

ttggacagtt aatcgagaag acaactgagc gcttaagaga aaa atg tct att aag        175
                                                Met Ser Ile Lys           
                                                1                         

aaa ctg tgg gtg ata cca aag gat ggt tac tta tta ctt ctt gac tat        223
Lys Leu Trp Val Ile Pro Lys Asp Gly Tyr Leu Leu Leu Leu Asp Tyr           
5                   10                  15                  20            

gat tca gat gaa gaa gaa gag cag gct cat tct gaa gta aag agg cca        271
Asp Ser Asp Glu Glu Glu Glu Gln Ala His Ser Glu Val Lys Arg Pro           
                25                  30                  35                

gca ttt ggc aaa cat gag aat atg ccg cct cac gta gaa gca gat gaa        319
Ala Phe Gly Lys His Glu Asn Met Pro Pro His Val Glu Ala Asp Glu           
            40                  45                  50                    

gat ata aga gat gaa caa gac agt atg ttg gat aaa tct gga gaa aac        367
Asp Ile Arg Asp Glu Gln Asp Ser Met Leu Asp Lys Ser Gly Glu Asn           
        55                  60                  65                        

gta agt ttc tca gag gaa tgg cag cgt ttt gca cgt tct gta gag aca        415
Val Ser Phe Ser Glu Glu Trp Gln Arg Phe Ala Arg Ser Val Glu Thr           
    70                  75                  80                            

cca atg gaa aac tgg aat ttg tta agt ggt gaa cag caa gtt agg aat        463
Pro Met Glu Asn Trp Asn Leu Leu Ser Gly Glu Gln Gln Val Arg Asn           
85                  90                  95                  100           

gct tca gaa ttg gac ctt atg gaa gta cag aat cca gta act cat gat        511
Ala Ser Glu Leu Asp Leu Met Glu Val Gln Asn Pro Val Thr His Asp           
                105                 110                 115               

gat ggg aat gca aat cct gaa gaa gta gtt gga gat aca cga aag aag        559
Asp Gly Asn Ala Asn Pro Glu Glu Val Val Gly Asp Thr Arg Lys Lys           
            120                 125                 130                   

atc aac aac aaa ttg tgt gag cag aag ttt gat atg gat ata cag aaa        607
Ile Asn Asn Lys Leu Cys Glu Gln Lys Phe Asp Met Asp Ile Gln Lys           
        135                 140                 145                       

ttc aat gaa gaa caa gaa aaa tca gtg aac aat tat caa aaa gaa caa        655
Phe Asn Glu Glu Gln Glu Lys Ser Val Asn Asn Tyr Gln Lys Glu Gln           
    150                 155                 160                           

caa gca tta aaa ctg tcc gaa tgt agt cag agt ccg acc atg gaa gca        703
Gln Ala Leu Lys Leu Ser Glu Cys Ser Gln Ser Pro Thr Met Glu Ala           
165                 170                 175                 180           

att gaa gac atg cat gag aag tcc atg gag ggt ttg atg aac atg gag        751
Ile Glu Asp Met His Glu Lys Ser Met Glu Gly Leu Met Asn Met Glu           
                185                 190                 195               

acc aac aac tac gat atg ctt ttt gat gta gat ggt gaa gag aca tta        799
Thr Asn Asn Tyr Asp Met Leu Phe Asp Val Asp Gly Glu Glu Thr Leu           
            200                 205                 210                   

tga agcatactct gaagtactct tctcctttcc catcttcaga ctaatgaagc             852

atacatattt ctcacttgct ggtacatttg taacctaata aaaaattcac taacattttt      912

gtctcctatg aa                                                          924


<210>  16
<211>  212
<212>  PRT
<213>  Mus musculus - Xlr-related, meiosis regulated Xmr

<400>  16

Met Ser Ile Lys Lys Leu Trp Val Ile Pro Lys Asp Gly Tyr Leu Leu 
1               5                   10                  15      


Leu Leu Asp Tyr Asp Ser Asp Glu Glu Glu Glu Gln Ala His Ser Glu 
            20                  25                  30          


Val Lys Arg Pro Ala Phe Gly Lys His Glu Asn Met Pro Pro His Val 
        35                  40                  45              


Glu Ala Asp Glu Asp Ile Arg Asp Glu Gln Asp Ser Met Leu Asp Lys 
    50                  55                  60                  


Ser Gly Glu Asn Val Ser Phe Ser Glu Glu Trp Gln Arg Phe Ala Arg 
65                  70                  75                  80  


Ser Val Glu Thr Pro Met Glu Asn Trp Asn Leu Leu Ser Gly Glu Gln 
                85                  90                  95      


Gln Val Arg Asn Ala Ser Glu Leu Asp Leu Met Glu Val Gln Asn Pro 
            100                 105                 110         


Val Thr His Asp Asp Gly Asn Ala Asn Pro Glu Glu Val Val Gly Asp 
        115                 120                 125             


Thr Arg Lys Lys Ile Asn Asn Lys Leu Cys Glu Gln Lys Phe Asp Met 
    130                 135                 140                 


Asp Ile Gln Lys Phe Asn Glu Glu Gln Glu Lys Ser Val Asn Asn Tyr 
145                 150                 155                 160 


Gln Lys Glu Gln Gln Ala Leu Lys Leu Ser Glu Cys Ser Gln Ser Pro 
                165                 170                 175     


Thr Met Glu Ala Ile Glu Asp Met His Glu Lys Ser Met Glu Gly Leu 
            180                 185                 190         


Met Asn Met Glu Thr Asn Asn Tyr Asp Met Leu Phe Asp Val Asp Gly 
        195                 200                 205             


Glu Glu Thr Leu 
    210         


<210>  17
<211>  1924
<212>  DNA
<213>  Mus musculus - Pentraxin-related gene (Ptx3)


<220>
<221>  CDS
<222>  (176)..(1321)

<400>  17
gggaactccc tcgcgctgtg ccaccgacat tagtcattca tcccgctcat gctttggagc       60

gtttattaag ggcttcactc ctgcctcaca ctatctctcc cgggctcaaa ctcggatcac      120

tgtagagtct cgcttcttcc cctgcggctg cgaagcaaat ttcgcctctc cagca atg       178
                                                             Met          
                                                             1            

cac ctc cct gcg atc ctg ctt tgt gct ctc tgg tct gca gta gtg gct        226
His Leu Pro Ala Ile Leu Leu Cys Ala Leu Trp Ser Ala Val Val Ala           
            5                   10                  15                    

gag acc tcg gat gac tac gag ctc atg tat gtg aat ttg gac aac gaa        274
Glu Thr Ser Asp Asp Tyr Glu Leu Met Tyr Val Asn Leu Asp Asn Glu           
        20                  25                  30                        

ata gac aat gga ctt cat ccc acc gag gac ccc acg cca tgc gac tgc        322
Ile Asp Asn Gly Leu His Pro Thr Glu Asp Pro Thr Pro Cys Asp Cys           
    35                  40                  45                            

cgc cag gag cac tcg gag tgg gac aag ctg ttc atc atg ctg gag aac        370
Arg Gln Glu His Ser Glu Trp Asp Lys Leu Phe Ile Met Leu Glu Asn           
50                  55                  60                  65            

tcg cag atg cgg gag ggc atg ctg ttg cag gcc acc gac gac gtc ctc        418
Ser Gln Met Arg Glu Gly Met Leu Leu Gln Ala Thr Asp Asp Val Leu           
                70                  75                  80                

cgt gga gag ctg cag cgg ctg cgg gca gag ctg ggg cgg ctg gcg ggc        466
Arg Gly Glu Leu Gln Arg Leu Arg Ala Glu Leu Gly Arg Leu Ala Gly           
            85                  90                  95                    

ggc atg gcg agg ccg tgc gca gcc ggt ggc ccc gca gac gcc agg ctg        514
Gly Met Ala Arg Pro Cys Ala Ala Gly Gly Pro Ala Asp Ala Arg Leu           
        100                 105                 110                       

gtg cgg gcg ctg gag ccg ctg ctg cag gag agc cgt gac gcg agc ctc        562
Val Arg Ala Leu Glu Pro Leu Leu Gln Glu Ser Arg Asp Ala Ser Leu           
    115                 120                 125                           

agg ctg gcg cgc ctg gag gac gcg gag gcg cgg cga ccc gag gcg aca        610
Arg Leu Ala Arg Leu Glu Asp Ala Glu Ala Arg Arg Pro Glu Ala Thr           
130                 135                 140                 145           

gtg cct ggc cta ggc gct gtg ctg gag gaa ctg cgg cgg acg cgc gcc        658
Val Pro Gly Leu Gly Ala Val Leu Glu Glu Leu Arg Arg Thr Arg Ala           
                150                 155                 160               

gac ctg agc gcc gtg cag agc tgg gtc gcc cgc cac tgg ctg ccc gca        706
Asp Leu Ser Ala Val Gln Ser Trp Val Ala Arg His Trp Leu Pro Ala           
            165                 170                 175                   

ggt tgt gaa aca gca att ttc ttc cca atg cgt tcg aag aag att ttt        754
Gly Cys Glu Thr Ala Ile Phe Phe Pro Met Arg Ser Lys Lys Ile Phe           
        180                 185                 190                       

gga agc gtg cat cct gtg aga cca atg aag ctt gaa tct ttt agt act        802
Gly Ser Val His Pro Val Arg Pro Met Lys Leu Glu Ser Phe Ser Thr           
    195                 200                 205                           

tgc att tgg gtc aaa gcc aca gat gta tta aac aaa acc atc ctg ttt        850
Cys Ile Trp Val Lys Ala Thr Asp Val Leu Asn Lys Thr Ile Leu Phe           
210                 215                 220                 225           

tct tat ggc aca aag tgg aac ccc tat gag att cag ctg tac ctc agt        898
Ser Tyr Gly Thr Lys Trp Asn Pro Tyr Glu Ile Gln Leu Tyr Leu Ser           
                230                 235                 240               

tcc cag tcc cta gtg ttg gtg gtg ggt gga aag gag aac aag ctg gct        946
Ser Gln Ser Leu Val Leu Val Val Gly Gly Lys Glu Asn Lys Leu Ala           
            245                 250                 255                   

gca gac act gtg gtg tcc ctg ggg agg tgg tcc cac ctg tgt ggc acc        994
Ala Asp Thr Val Val Ser Leu Gly Arg Trp Ser His Leu Cys Gly Thr           
        260                 265                 270                       

tgg agt tca gag cag ggg agc atg tcc ctg tgg gca aac ggg gag ctg       1042
Trp Ser Ser Glu Gln Gly Ser Met Ser Leu Trp Ala Asn Gly Glu Leu           
    275                 280                 285                           

gtg gct acc act gta gag atg gcc aaa agt cac tct gtt cct gag ggt       1090
Val Ala Thr Thr Val Glu Met Ala Lys Ser His Ser Val Pro Glu Gly           
290                 295                 300                 305           

gga ctc cta cag att ggc caa gaa aag aat ggt tgc tgt gta ggt ggg       1138
Gly Leu Leu Gln Ile Gly Gln Glu Lys Asn Gly Cys Cys Val Gly Gly           
                310                 315                 320               

ggc ttt gac gaa tca tta gca ttt tct gga aga atc aca ggc ttc aat       1186
Gly Phe Asp Glu Ser Leu Ala Phe Ser Gly Arg Ile Thr Gly Phe Asn           
            325                 330                 335                   

atc tgg gat cgg gtt ctc agc gag gag gag ata cgg gcc agt gga gga       1234
Ile Trp Asp Arg Val Leu Ser Glu Glu Glu Ile Arg Ala Ser Gly Gly           
        340                 345                 350                       

gtc gaa tcc tgt cac atc cgg gga aat gtc gtc ggg tgg gga gtc aca       1282
Val Glu Ser Cys His Ile Arg Gly Asn Val Val Gly Trp Gly Val Thr           
    355                 360                 365                           

gag att cag gcg cac gga gga gcc cag tat gtt tct taa gtgttgtgaa        1331
Glu Ile Gln Ala His Gly Gly Ala Gln Tyr Val Ser                           
370                 375                 380                               

aatctacttg aagccaaagg agactcacat tttaaatatg ccagttggaa aagtctgaaa     1391

acttcggtgc gtaatagacg aatgaaggag agacttgaga ttgtctttgt ttatcttggc     1451

aaaatactga atacacagtt gaagggaagg cttgagagag ggctccggga tgttgttact     1511

aagccttata ctgtggtgct ttcagattaa tgtctgcctc tgtcagataa accctcagat     1571

aactaaacag gactggactc tgaacagagg gacgattgtg tgactttttt ttttttttat     1631

tttggttaat tttattttgg ccagagacat ttttatattg gaagaataac aaaacaagct     1691

ctgttgccca ttgttcattc tttctggtgt gtattttgtg acaaaagaga tgatgagaaa     1751

accatattta taccacaaag tgacttatta acgaacataa atgtagctta cgtgttataa     1811

tccaatgttc catttgggag aaggtagttg tgtaatttat attgtgaaat gtatttgtat     1871

taattttatt tttgtaaaag tctactgtaa ataaaatgtt ttataaagct aaa            1924


<210>  18
<211>  381
<212>  PRT
<213>  Mus musculus - Pentraxin-related gene (Ptx3)

<400>  18

Met His Leu Pro Ala Ile Leu Leu Cys Ala Leu Trp Ser Ala Val Val 
1               5                   10                  15      


Ala Glu Thr Ser Asp Asp Tyr Glu Leu Met Tyr Val Asn Leu Asp Asn 
            20                  25                  30          


Glu Ile Asp Asn Gly Leu His Pro Thr Glu Asp Pro Thr Pro Cys Asp 
        35                  40                  45              


Cys Arg Gln Glu His Ser Glu Trp Asp Lys Leu Phe Ile Met Leu Glu 
    50                  55                  60                  


Asn Ser Gln Met Arg Glu Gly Met Leu Leu Gln Ala Thr Asp Asp Val 
65                  70                  75                  80  


Leu Arg Gly Glu Leu Gln Arg Leu Arg Ala Glu Leu Gly Arg Leu Ala 
                85                  90                  95      


Gly Gly Met Ala Arg Pro Cys Ala Ala Gly Gly Pro Ala Asp Ala Arg 
            100                 105                 110         


Leu Val Arg Ala Leu Glu Pro Leu Leu Gln Glu Ser Arg Asp Ala Ser 
        115                 120                 125             


Leu Arg Leu Ala Arg Leu Glu Asp Ala Glu Ala Arg Arg Pro Glu Ala 
    130                 135                 140                 


Thr Val Pro Gly Leu Gly Ala Val Leu Glu Glu Leu Arg Arg Thr Arg 
145                 150                 155                 160 


Ala Asp Leu Ser Ala Val Gln Ser Trp Val Ala Arg His Trp Leu Pro 
                165                 170                 175     


Ala Gly Cys Glu Thr Ala Ile Phe Phe Pro Met Arg Ser Lys Lys Ile 
            180                 185                 190         


Phe Gly Ser Val His Pro Val Arg Pro Met Lys Leu Glu Ser Phe Ser 
        195                 200                 205             


Thr Cys Ile Trp Val Lys Ala Thr Asp Val Leu Asn Lys Thr Ile Leu 
    210                 215                 220                 


Phe Ser Tyr Gly Thr Lys Trp Asn Pro Tyr Glu Ile Gln Leu Tyr Leu 
225                 230                 235                 240 


Ser Ser Gln Ser Leu Val Leu Val Val Gly Gly Lys Glu Asn Lys Leu 
                245                 250                 255     


Ala Ala Asp Thr Val Val Ser Leu Gly Arg Trp Ser His Leu Cys Gly 
            260                 265                 270         


Thr Trp Ser Ser Glu Gln Gly Ser Met Ser Leu Trp Ala Asn Gly Glu 
        275                 280                 285             


Leu Val Ala Thr Thr Val Glu Met Ala Lys Ser His Ser Val Pro Glu 
    290                 295                 300                 


Gly Gly Leu Leu Gln Ile Gly Gln Glu Lys Asn Gly Cys Cys Val Gly 
305                 310                 315                 320 


Gly Gly Phe Asp Glu Ser Leu Ala Phe Ser Gly Arg Ile Thr Gly Phe 
                325                 330                 335     


Asn Ile Trp Asp Arg Val Leu Ser Glu Glu Glu Ile Arg Ala Ser Gly 
            340                 345                 350         


Gly Val Glu Ser Cys His Ile Arg Gly Asn Val Val Gly Trp Gly Val 
        355                 360                 365             


Thr Glu Ile Gln Ala His Gly Gly Ala Gln Tyr Val Ser 
    370                 375                 380     


<210>  19
<211>  1908
<212>  DNA
<213>  Homo sapiens - Pentraxin-related gene


<220>
<221>  CDS
<222>  (117)..(1262)

<400>  19
catttattaa ggactctctg ctccagcctc tcactctcac tctcctccgc tcaaactcag       60

ctcacttgag agtctcctcc cgccagctgt ggaaagaact ttgcgtctct ccagca atg      119
                                                              Met         
                                                              1           

cat ctc ctt gcg att ctg ttt tgt gct ctc tgg tct gca gtg ttg gcc        167
His Leu Leu Ala Ile Leu Phe Cys Ala Leu Trp Ser Ala Val Leu Ala           
            5                   10                  15                    

gag aac tcg gat gat tat gat ctc atg tat gtg aat ttg gac aac gaa        215
Glu Asn Ser Asp Asp Tyr Asp Leu Met Tyr Val Asn Leu Asp Asn Glu           
        20                  25                  30                        

ata gac aat gga ctc cat ccc act gag gac ccc acg ccg tgc gac tgc        263
Ile Asp Asn Gly Leu His Pro Thr Glu Asp Pro Thr Pro Cys Asp Cys           
    35                  40                  45                            

ggt cag gag cac tcg gaa tgg gac aag ctc ttc atc atg ctg gag aac        311
Gly Gln Glu His Ser Glu Trp Asp Lys Leu Phe Ile Met Leu Glu Asn           
50                  55                  60                  65            

tcg cag atg aga gag cgc atg ctg ctg caa gcc acg gac gac gtc ctg        359
Ser Gln Met Arg Glu Arg Met Leu Leu Gln Ala Thr Asp Asp Val Leu           
                70                  75                  80                

cgg ggc gag ctg cag agg ctg cgg gag gag ctg ggc cgg ctc gcg gaa        407
Arg Gly Glu Leu Gln Arg Leu Arg Glu Glu Leu Gly Arg Leu Ala Glu           
            85                  90                  95                    

agc ctg gcg agg ccg tgc gcg ccg ggg gct ccc gca gag gcc agg ctg        455
Ser Leu Ala Arg Pro Cys Ala Pro Gly Ala Pro Ala Glu Ala Arg Leu           
        100                 105                 110                       

acc agt gct ctg gac gag ctg ctg cag gcg acc cgc gac gcg ggc cgc        503
Thr Ser Ala Leu Asp Glu Leu Leu Gln Ala Thr Arg Asp Ala Gly Arg           
    115                 120                 125                           

agg ctg gcg cgt atg gag ggc gcg gag gcg cag cgc cca gag gag gcg        551
Arg Leu Ala Arg Met Glu Gly Ala Glu Ala Gln Arg Pro Glu Glu Ala           
130                 135                 140                 145           

ggg cgc gcc ctg gcc gcg gtg cta gag gag ctg cgg cag acg cga gcc        599
Gly Arg Ala Leu Ala Ala Val Leu Glu Glu Leu Arg Gln Thr Arg Ala           
                150                 155                 160               

gac ctg cac gcg gtg cag ggc tgg gct gcc cgg agc tgg ctg ccg gca        647
Asp Leu His Ala Val Gln Gly Trp Ala Ala Arg Ser Trp Leu Pro Ala           
            165                 170                 175                   

ggt tgt gaa aca gct att tta ttc cca atg cgt tcc aag aag att ttt        695
Gly Cys Glu Thr Ala Ile Leu Phe Pro Met Arg Ser Lys Lys Ile Phe           
        180                 185                 190                       

gga agc gtg cat cca gtg aga cca atg agg ctt gag tct ttt agt gcc        743
Gly Ser Val His Pro Val Arg Pro Met Arg Leu Glu Ser Phe Ser Ala           
    195                 200                 205                           

tgc att tgg gtc aaa gcc aca gat gta tta aac aaa acc atc ctg ttt        791
Cys Ile Trp Val Lys Ala Thr Asp Val Leu Asn Lys Thr Ile Leu Phe           
210                 215                 220                 225           

tcc tat ggc aca aag agg aat cca tat gaa atc cag ctg tat ctc agc        839
Ser Tyr Gly Thr Lys Arg Asn Pro Tyr Glu Ile Gln Leu Tyr Leu Ser           
                230                 235                 240               

tac caa tcc ata gtg ttt gtg gtg ggt gga gag gag aac aaa ctg gtt        887
Tyr Gln Ser Ile Val Phe Val Val Gly Gly Glu Glu Asn Lys Leu Val           
            245                 250                 255                   

gct gaa gcc atg gtt tcc ctg gga agg tgg acc cac ctg tgc ggc acc        935
Ala Glu Ala Met Val Ser Leu Gly Arg Trp Thr His Leu Cys Gly Thr           
        260                 265                 270                       

tgg aat tca gag gaa ggg ctc aca tcc ttg tgg gta aat ggt gaa ctg        983
Trp Asn Ser Glu Glu Gly Leu Thr Ser Leu Trp Val Asn Gly Glu Leu           
    275                 280                 285                           

gcg gct acc act gtt gag atg gcc aca ggt cac att gtt cct gag gga       1031
Ala Ala Thr Thr Val Glu Met Ala Thr Gly His Ile Val Pro Glu Gly           
290                 295                 300                 305           

gga atc ctg cag att ggc caa gaa aag aat ggc tgc tgt gtg ggt ggt       1079
Gly Ile Leu Gln Ile Gly Gln Glu Lys Asn Gly Cys Cys Val Gly Gly           
                310                 315                 320               

ggc ttt gat gaa aca tta gcc ttc tct ggg aga ctc aca ggc ttc aat       1127
Gly Phe Asp Glu Thr Leu Ala Phe Ser Gly Arg Leu Thr Gly Phe Asn           
            325                 330                 335                   

atc tgg gat agt gtt ctt agc aat gaa gag ata aga gag acc gga gga       1175
Ile Trp Asp Ser Val Leu Ser Asn Glu Glu Ile Arg Glu Thr Gly Gly           
        340                 345                 350                       

gca gag tct tgt cac atc cgg ggg aat att gtt ggg tgg gga gtc aca       1223
Ala Glu Ser Cys His Ile Arg Gly Asn Ile Val Gly Trp Gly Val Thr           
    355                 360                 365                           

gag atc cag cca cat gga gga gct cag tat gtt tca taa atgttgtgaa        1272
Glu Ile Gln Pro His Gly Gly Ala Gln Tyr Val Ser                           
370                 375                 380                               

actccacttg aagccaaaga aagaaactca cacttaaaac acatgccagt tgggaaggtc     1332

tgaaaactca gtgcataata ggaacacttg agactaatga aagagagagt tgagaccaat     1392

ctttatttgt actggccaaa tactgaataa acagttgaag gaaagacatt ggaaaaagct     1452

tttgaggata atgttactag actttatgcc atggtgcttt cagtttaatg ctgtgtctct     1512

gtcagataaa ctctcaaata attaaaaagg actgtattgt tgaacagagg gacaattgtt     1572

ttacttttct ttggttaatt ttgttttggc cagagatgaa ttttacattg gaagaataac     1632

aaaataagat ttgttgtcca ttgttcattg ttattggtat gtaccttatt acaaaaaaaa     1692

tgatgaaaac atatttatac tacaaggtga cttaacaact ataaatgtag tttatgtgtt     1752

ataatcgaat gtcacgtttt tgagaagata gtcatataag ttatattgca aaagggattt     1812

gtattaattt aagactattt ttgtaaagct ctactgtaaa taaaatattt tataaaacta     1872

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                               1908


<210>  20
<211>  381
<212>  PRT
<213>  Homo sapiens - Pentraxin-related gene

<400>  20

Met His Leu Leu Ala Ile Leu Phe Cys Ala Leu Trp Ser Ala Val Leu 
1               5                   10                  15      


Ala Glu Asn Ser Asp Asp Tyr Asp Leu Met Tyr Val Asn Leu Asp Asn 
            20                  25                  30          


Glu Ile Asp Asn Gly Leu His Pro Thr Glu Asp Pro Thr Pro Cys Asp 
        35                  40                  45              


Cys Gly Gln Glu His Ser Glu Trp Asp Lys Leu Phe Ile Met Leu Glu 
    50                  55                  60                  


Asn Ser Gln Met Arg Glu Arg Met Leu Leu Gln Ala Thr Asp Asp Val 
65                  70                  75                  80  


Leu Arg Gly Glu Leu Gln Arg Leu Arg Glu Glu Leu Gly Arg Leu Ala 
                85                  90                  95      


Glu Ser Leu Ala Arg Pro Cys Ala Pro Gly Ala Pro Ala Glu Ala Arg 
            100                 105                 110         


Leu Thr Ser Ala Leu Asp Glu Leu Leu Gln Ala Thr Arg Asp Ala Gly 
        115                 120                 125             


Arg Arg Leu Ala Arg Met Glu Gly Ala Glu Ala Gln Arg Pro Glu Glu 
    130                 135                 140                 


Ala Gly Arg Ala Leu Ala Ala Val Leu Glu Glu Leu Arg Gln Thr Arg 
145                 150                 155                 160 


Ala Asp Leu His Ala Val Gln Gly Trp Ala Ala Arg Ser Trp Leu Pro 
                165                 170                 175     


Ala Gly Cys Glu Thr Ala Ile Leu Phe Pro Met Arg Ser Lys Lys Ile 
            180                 185                 190         


Phe Gly Ser Val His Pro Val Arg Pro Met Arg Leu Glu Ser Phe Ser 
        195                 200                 205             


Ala Cys Ile Trp Val Lys Ala Thr Asp Val Leu Asn Lys Thr Ile Leu 
    210                 215                 220                 


Phe Ser Tyr Gly Thr Lys Arg Asn Pro Tyr Glu Ile Gln Leu Tyr Leu 
225                 230                 235                 240 


Ser Tyr Gln Ser Ile Val Phe Val Val Gly Gly Glu Glu Asn Lys Leu 
                245                 250                 255     


Val Ala Glu Ala Met Val Ser Leu Gly Arg Trp Thr His Leu Cys Gly 
            260                 265                 270         


Thr Trp Asn Ser Glu Glu Gly Leu Thr Ser Leu Trp Val Asn Gly Glu 
        275                 280                 285             


Leu Ala Ala Thr Thr Val Glu Met Ala Thr Gly His Ile Val Pro Glu 
    290                 295                 300                 


Gly Gly Ile Leu Gln Ile Gly Gln Glu Lys Asn Gly Cys Cys Val Gly 
305                 310                 315                 320 


Gly Gly Phe Asp Glu Thr Leu Ala Phe Ser Gly Arg Leu Thr Gly Phe 
                325                 330                 335     


Asn Ile Trp Asp Ser Val Leu Ser Asn Glu Glu Ile Arg Glu Thr Gly 
            340                 345                 350         


Gly Ala Glu Ser Cys His Ile Arg Gly Asn Ile Val Gly Trp Gly Val 
        355                 360                 365             


Thr Glu Ile Gln Pro His Gly Gly Ala Gln Tyr Val Ser 
    370                 375                 380     


<210>  21
<211>  3016
<212>  DNA
<213>  Mus musculus - CD36 antigen


<220>
<221>  CDS
<222>  (264)..(1682)

<400>  21
actgaggact ttttcttctt cacagctgcc ttctgaaatg tgtggagcaa ctggtggatg       60

gtttcctagc ctttcaaagg tagtttacaa atgatttgaa gtgctgatcc tttcagagtc      120

tcaacagatt atttcttaaa cagctcatac attgctgttt atgcatgaat tagtagaacc      180

gggccacgta gaaaacactg tgattgtacc tgggagttgg cgagaaaacc agtgctctcc      240

cttgattctg ctgcacgagg aga atg ggc tgt gat cgg aac tgt ggg ctc att      293
                          Met Gly Cys Asp Arg Asn Cys Gly Leu Ile         
                          1               5                   10          

gct gga gct gtt att ggt gca gtc ctg gct gtg ttt gga ggc att ctc        341
Ala Gly Ala Val Ile Gly Ala Val Leu Ala Val Phe Gly Gly Ile Leu           
                15                  20                  25                

atg cca gtc gga gac atg ctt att ggg aag aca atc aaa agg gaa gtt        389
Met Pro Val Gly Asp Met Leu Ile Gly Lys Thr Ile Lys Arg Glu Val           
            30                  35                  40                    

gtc ctt gaa gaa gga acc act gct ttc aaa aac tgg gtt aaa aca ggc        437
Val Leu Glu Glu Gly Thr Thr Ala Phe Lys Asn Trp Val Lys Thr Gly           
        45                  50                  55                        

acc act gtg tac aga cag ttt tgg atc ttt gat gtg caa aac cca gat        485
Thr Thr Val Tyr Arg Gln Phe Trp Ile Phe Asp Val Gln Asn Pro Asp           
    60                  65                  70                            

gac gtg gca aag aac agc agc aaa atc aag gtt aaa caa aga ggt cct        533
Asp Val Ala Lys Asn Ser Ser Lys Ile Lys Val Lys Gln Arg Gly Pro           
75                  80                  85                  90            

tac aca tac aga gtt cgt tat cta gcc aag gaa aat ata act cag gac        581
Tyr Thr Tyr Arg Val Arg Tyr Leu Ala Lys Glu Asn Ile Thr Gln Asp           
                95                  100                 105               

ccc gag gac cac act gtg tct ttt gta cag ccc aat gga gcc atc ttt        629
Pro Glu Asp His Thr Val Ser Phe Val Gln Pro Asn Gly Ala Ile Phe           
            110                 115                 120                   

gag cct tca ctg tct gtt gga aca gag gat gac aac ttc aca gtt ctg        677
Glu Pro Ser Leu Ser Val Gly Thr Glu Asp Asp Asn Phe Thr Val Leu           
        125                 130                 135                       

aat ctg gct gta gca gct gca cca cat atc tac caa aat tca ttt gtt        725
Asn Leu Ala Val Ala Ala Ala Pro His Ile Tyr Gln Asn Ser Phe Val           
    140                 145                 150                           

caa gtt gtg ctc aac tct ctt ata aaa aag tcc aag tct tct atg ttc        773
Gln Val Val Leu Asn Ser Leu Ile Lys Lys Ser Lys Ser Ser Met Phe           
155                 160                 165                 170           

caa aca aga tct ttg aaa gaa ctc ttg tgg ggt tac aaa gat cca ttc        821
Gln Thr Arg Ser Leu Lys Glu Leu Leu Trp Gly Tyr Lys Asp Pro Phe           
                175                 180                 185               

ctc agt ttg gtt cca tat cct ata agt acc aca gtt ggt gtg ttt tat        869
Leu Ser Leu Val Pro Tyr Pro Ile Ser Thr Thr Val Gly Val Phe Tyr           
            190                 195                 200                   

cct tac aat gac act gta gat gga gtt tat aaa gtt ttc aat gga aag        917
Pro Tyr Asn Asp Thr Val Asp Gly Val Tyr Lys Val Phe Asn Gly Lys           
        205                 210                 215                       

gat aac ata agc aaa gtt gcc ata att gag tcc tat aaa ggg aaa agg        965
Asp Asn Ile Ser Lys Val Ala Ile Ile Glu Ser Tyr Lys Gly Lys Arg           
    220                 225                 230                           

aat ttg tcc tat tgg cca agc tat tgc gac atg att aat ggc aca gac       1013
Asn Leu Ser Tyr Trp Pro Ser Tyr Cys Asp Met Ile Asn Gly Thr Asp           
235                 240                 245                 250           

gca gcc tcc ttt cca cct ttt gtt gaa aag tct cgg aca ttg aga ttc       1061
Ala Ala Ser Phe Pro Pro Phe Val Glu Lys Ser Arg Thr Leu Arg Phe           
                255                 260                 265               

ttt tcc tct gac att tgc agg tct atc tac gct gtg ttc gga tct gaa       1109
Phe Ser Ser Asp Ile Cys Arg Ser Ile Tyr Ala Val Phe Gly Ser Glu           
            270                 275                 280                   

atc gac ctt aaa gga atc ccc gtg tac aga ttt gtt ctt cca gcc aat       1157
Ile Asp Leu Lys Gly Ile Pro Val Tyr Arg Phe Val Leu Pro Ala Asn           
        285                 290                 295                       

gcc ttt gca tca ccc ctc cag aat cca gac aac cat tgt ttc tgc act       1205
Ala Phe Ala Ser Pro Leu Gln Asn Pro Asp Asn His Cys Phe Cys Thr           
    300                 305                 310                           

gaa aaa gta atc tcc aat aac tgt aca tct tat ggt gtg cta gac att       1253
Glu Lys Val Ile Ser Asn Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile           
315                 320                 325                 330           

ggc aaa tgc aaa gaa gga aag cct gtg tat att tcg ctt cca cat ttc       1301
Gly Lys Cys Lys Glu Gly Lys Pro Val Tyr Ile Ser Leu Pro His Phe           
                335                 340                 345               

cta cat gca agt cca gat gtt tca gaa cct att gaa ggc tta cat cca       1349
Leu His Ala Ser Pro Asp Val Ser Glu Pro Ile Glu Gly Leu His Pro           
            350                 355                 360                   

aat gaa gat gag cat agg aca tac tta gat gtg gaa ccc ata act gga       1397
Asn Glu Asp Glu His Arg Thr Tyr Leu Asp Val Glu Pro Ile Thr Gly           
        365                 370                 375                       

ttc act cta caa ttt gca aaa cga ctg cag gtc aac ata ttg gtc aag       1445
Phe Thr Leu Gln Phe Ala Lys Arg Leu Gln Val Asn Ile Leu Val Lys           
    380                 385                 390                           

cca gct aga aaa ata gaa gca tta aag aat ctg aag aga cct tac att       1493
Pro Ala Arg Lys Ile Glu Ala Leu Lys Asn Leu Lys Arg Pro Tyr Ile           
395                 400                 405                 410           

gta cct ata ctg tgg cta aat gag act ggg acc att ggt gat gaa aaa       1541
Val Pro Ile Leu Trp Leu Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys           
                415                 420                 425               

gca gaa atg ttc aaa aca caa gtg act ggg aaa atc aag ctc ctt ggc       1589
Ala Glu Met Phe Lys Thr Gln Val Thr Gly Lys Ile Lys Leu Leu Gly           
            430                 435                 440                   

atg gta gag atg gcc tta ctt ggg att gga gtg gtg atg ttt gtt gct       1637
Met Val Glu Met Ala Leu Leu Gly Ile Gly Val Val Met Phe Val Ala           
        445                 450                 455                       

ttt atg att tca tat tgt gct tgc aaa tcc aag aat gga aaa taa           1682
Phe Met Ile Ser Tyr Cys Ala Cys Lys Ser Lys Asn Gly Lys                   
    460                 465                 470                           

gtagtggatg agcctacata tacactggct acatctttgg taaagccgat ctacaaaatg     1742

aaaacttaat atatgcttcg tttttacaaa acacacctat ctttaggaga agaaatggtg     1802

gtgtgtgctc tctctctctt tctctttctc tcttattgca gatatatatt tatttgtaaa     1862

tatatatata tgcaataagt cacagcatat ttcaaaagat taatatgtca ctataggcaa     1922

tattttttaa taaaatcttg cacttttatt aaaagtccat catttgcaac tgagtggact     1982

tcaatttctg tagacccaat tatcctgttt ggttctgatt tactgatttg ttccatgttg     2042

gcaaatttca agaatgtaca ttctgagaaa tttttgtttt ccctcactgg aggaaactgc     2102

tatcatgact ggggtggccc ctttgtttat agcaaatttg gcttgcaact gtcagcacat     2162

ggcataagta taacatcttg aaagacttaa gaatgaaaaa tgaacaattc acatgtgagc     2222

cactgcttat atattaagtc tctccctctc tggagttctt ggctacagca aggccagata     2282

tcacattggt tttggttttg ttgtttttgt tttgtttttg ttttttactc tctgacacag     2342

agcttatgaa atggactttt tttttttttt ttagcatacc ttagctcttt gtattttaag     2402

tatgtcgtca tgttccatgc tgcatagctc tttaaaaaac ctgagtaggt ttttctcttt     2462

ctgctcagct gcaactaata acaaccttgg agagctgtta tagtgttaaa agatgtaaat     2522

gataataaaa gaattattaa atggaatcct acaaaagcaa caatgggctt taatatatat     2582

ttgtggtaat atctcctgct ttcataatca cccaaaaaaa ggactggttt ctaacattaa     2642

aagaagtcgt tccttaaatt caaccttttt gtctagttac tattgaatca cagtatgtta     2702

tttattgtat tttattttgt tttttgtaga agtgttctat ctgagattct gtgtccttct     2762

gaatcattta acctttctgc tatgtcttaa tgcaattgaa cacagatatt ttgttataat     2822

tttatagcag cagtgtgaga ctgaaggcaa atattttcca gggtaagaca cagtgatagg     2882

ttgttctact tcctttagca gcataatcaa tttcacttag tattagtccc aataaattct     2942

ggtataagac acaaaataaa aacaaacatt ttctgttcta tacgtagaaa aataaaagga     3002

aaggtgagac aact                                                       3016


<210>  22
<211>  472
<212>  PRT
<213>  Mus musculus - CD36 antigen

<400>  22

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Met 
            20                  25                  30          


Leu Ile Gly Lys Thr Ile Lys Arg Glu Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Thr Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Thr Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Asp Asp Val Ala Lys Asn Ser 
65                  70                  75                  80  


Ser Lys Ile Lys Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Tyr Leu Ala Lys Glu Asn Ile Thr Gln Asp Pro Glu Asp His Thr Val 
            100                 105                 110         


Ser Phe Val Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Asp Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Pro His Ile Tyr Gln Asn Ser Phe Val Gln Val Val Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Lys Lys Ser Lys Ser Ser Met Phe Gln Thr Arg Ser Leu Lys 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Lys Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Ile Ser Thr Thr Val Gly Val Phe Tyr Pro Tyr Asn Asp Thr Val 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Glu Ser Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Pro 
225                 230                 235                 240 


Ser Tyr Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Arg Thr Leu Arg Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Gly Ser Glu Ile Asp Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ala Asn Ala Phe Ala Ser Pro Leu 
    290                 295                 300                 


Gln Asn Pro Asp Asn His Cys Phe Cys Thr Glu Lys Val Ile Ser Asn 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Gly Lys Cys Lys Glu Gly 
                325                 330                 335     


Lys Pro Val Tyr Ile Ser Leu Pro His Phe Leu His Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Glu Gly Leu His Pro Asn Glu Asp Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Val Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Ile Leu Val Lys Pro Ala Arg Lys Ile Glu 
385                 390                 395                 400 


Ala Leu Lys Asn Leu Lys Arg Pro Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Glu Met Phe Lys Thr 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Lys Leu Leu Gly Met Val Glu Met Ala Leu 
        435                 440                 445             


Leu Gly Ile Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Lys Ser Lys Asn Gly Lys 
465                 470         


<210>  23
<211>  1870
<212>  DNA
<213>  Homo sapiens - CD36 antigen


<220>
<221>  CDS
<222>  (211)..(1629)

<400>  23
gaaaaatcct tcttagccat tttaaagata gctttccaat gattagacga attgattctt       60

tctgtgactc atcagttcct ttcctgtaaa attcatgtct tgctgttgat ttgtgaataa      120

gaaccagagc ttgtagaaac cactttaatc atatccagga gtttgcaaga aacaggtgct      180

taacactaat tcacctcctg aacaagaaaa atg ggc tgt gac cgg aac tgt ggg       234
                                 Met Gly Cys Asp Arg Asn Cys Gly          
                                 1               5                        

ctc atc gct ggg gct gtc att ggt gct gtc ctg gct gtg ttt gga ggt        282
Leu Ile Ala Gly Ala Val Ile Gly Ala Val Leu Ala Val Phe Gly Gly           
    10                  15                  20                            

att cta atg cca gtt gga gac ctg ctt atc cag aag aca att aaa aag        330
Ile Leu Met Pro Val Gly Asp Leu Leu Ile Gln Lys Thr Ile Lys Lys           
25                  30                  35                  40            

caa gtt gtc ctc gaa gaa ggt aca att gct ttt aaa aat tgg gtt aaa        378
Gln Val Val Leu Glu Glu Gly Thr Ile Ala Phe Lys Asn Trp Val Lys           
                45                  50                  55                

aca ggc aca gaa gtt tac aga cag ttt tgg atc ttt gat gtg caa aat        426
Thr Gly Thr Glu Val Tyr Arg Gln Phe Trp Ile Phe Asp Val Gln Asn           
            60                  65                  70                    

cca cag gaa gtg atg atg aac agc agc aac att caa gtt aag caa aga        474
Pro Gln Glu Val Met Met Asn Ser Ser Asn Ile Gln Val Lys Gln Arg           
        75                  80                  85                        

ggt cct tat acg tac aga gtt cgt ttt cta gcc aag gaa aat gta acc        522
Gly Pro Tyr Thr Tyr Arg Val Arg Phe Leu Ala Lys Glu Asn Val Thr           
    90                  95                  100                           

cag gac gct gag gac aac aca gtc tct ttc ctg cag ccc aat ggt gcc        570
Gln Asp Ala Glu Asp Asn Thr Val Ser Phe Leu Gln Pro Asn Gly Ala           
105                 110                 115                 120           

atc ttc gaa cct tca cta tca gtt gga aca gag gct gac aac ttc aca        618
Ile Phe Glu Pro Ser Leu Ser Val Gly Thr Glu Ala Asp Asn Phe Thr           
                125                 130                 135               

gtt ctc aat ctg gct gtg gca gct gca tcc cat atc tat caa aat caa        666
Val Leu Asn Leu Ala Val Ala Ala Ala Ser His Ile Tyr Gln Asn Gln           
            140                 145                 150                   

ttt gtt caa atg atc ctc aat tca ctt att aac aag tca aaa tct tct        714
Phe Val Gln Met Ile Leu Asn Ser Leu Ile Asn Lys Ser Lys Ser Ser           
        155                 160                 165                       

atg ttc caa gtc aga act ttg aga gaa ctg tta tgg ggc tat agg gat        762
Met Phe Gln Val Arg Thr Leu Arg Glu Leu Leu Trp Gly Tyr Arg Asp           
    170                 175                 180                           

cca ttt ttg agt ttg gtt ccg tac cct gtt act acc aca gtt ggt ctg        810
Pro Phe Leu Ser Leu Val Pro Tyr Pro Val Thr Thr Thr Val Gly Leu           
185                 190                 195                 200           

ttt tat cct tac aac aat act gca gat gga gtt tat aaa gtt ttc aat        858
Phe Tyr Pro Tyr Asn Asn Thr Ala Asp Gly Val Tyr Lys Val Phe Asn           
                205                 210                 215               

gga aaa gat aac ata agt aaa gtt gcc ata atc gac aca tat aaa ggt        906
Gly Lys Asp Asn Ile Ser Lys Val Ala Ile Ile Asp Thr Tyr Lys Gly           
            220                 225                 230                   

aaa agg aat ctg tcc tat tgg gaa agt cac tgc gac atg att aat ggt        954
Lys Arg Asn Leu Ser Tyr Trp Glu Ser His Cys Asp Met Ile Asn Gly           
        235                 240                 245                       

aca gat gca gcc tca ttt cca cct ttt gtt gag aaa agc cag gta ttg       1002
Thr Asp Ala Ala Ser Phe Pro Pro Phe Val Glu Lys Ser Gln Val Leu           
    250                 255                 260                           

cag ttc ttt tct tct gat att tgc agg tca atc tat gct gta ttt gaa       1050
Gln Phe Phe Ser Ser Asp Ile Cys Arg Ser Ile Tyr Ala Val Phe Glu           
265                 270                 275                 280           

tcc gac gtt aat ctg aaa gga atc cct gtg tat aga ttt gtt ctt cca       1098
Ser Asp Val Asn Leu Lys Gly Ile Pro Val Tyr Arg Phe Val Leu Pro           
                285                 290                 295               

tcc aag gcc ttt gcc tct cca gtt gaa aac cca gac aac tat tgt ttc       1146
Ser Lys Ala Phe Ala Ser Pro Val Glu Asn Pro Asp Asn Tyr Cys Phe           
            300                 305                 310                   

tgc aca gaa aaa att atc tca aaa aat tgt aca tca tat ggt gtg cta       1194
Cys Thr Glu Lys Ile Ile Ser Lys Asn Cys Thr Ser Tyr Gly Val Leu           
        315                 320                 325                       

gac atc agc aaa tgc aaa gaa ggg aga cct gtg tac att tca ctt cct       1242
Asp Ile Ser Lys Cys Lys Glu Gly Arg Pro Val Tyr Ile Ser Leu Pro           
    330                 335                 340                           

cat ttt ctg tat gca agt cct gat gtt tca gaa cct att gat gga tta       1290
His Phe Leu Tyr Ala Ser Pro Asp Val Ser Glu Pro Ile Asp Gly Leu           
345                 350                 355                 360           

aac cca aat gaa gaa gaa cat agg aca tac ttg gat att gaa cct ata       1338
Asn Pro Asn Glu Glu Glu His Arg Thr Tyr Leu Asp Ile Glu Pro Ile           
                365                 370                 375               

act gga ttc act tta caa ttt gca aaa cgg ctg cag gtc aac cta ttg       1386
Thr Gly Phe Thr Leu Gln Phe Ala Lys Arg Leu Gln Val Asn Leu Leu           
            380                 385                 390                   

gtc aag cca tca gaa aaa att caa gta tta aag aat ctg aag agg aac       1434
Val Lys Pro Ser Glu Lys Ile Gln Val Leu Lys Asn Leu Lys Arg Asn           
        395                 400                 405                       

tat att gtg cct att ctt tgg ctt aat gag act ggg acc att ggt gat       1482
Tyr Ile Val Pro Ile Leu Trp Leu Asn Glu Thr Gly Thr Ile Gly Asp           
    410                 415                 420                           

gag aag gca aac atg ttc aga agt caa gta act gga aaa ata aac ctc       1530
Glu Lys Ala Asn Met Phe Arg Ser Gln Val Thr Gly Lys Ile Asn Leu           
425                 430                 435                 440           

ctt ggc ctg ata gaa atg atc tta ctc agt gtt ggt gtg gtg atg ttt       1578
Leu Gly Leu Ile Glu Met Ile Leu Leu Ser Val Gly Val Val Met Phe           
                445                 450                 455               

gtt gct ttt atg att tca tat tgt gca tgc aga tcg aaa aca ata aaa       1626
Val Ala Phe Met Ile Ser Tyr Cys Ala Cys Arg Ser Lys Thr Ile Lys           
            460                 465                 470                   

taa gtatgtacca aaaaatattg cttcaataat attagcttat atattacttg            1679

ttttcacttt atcaaagaga agttacatat taggccatat atatttctag acatgtctag     1739

ccactgatca tttttaaata taggtaaata aacctataaa tattatcacg cagatcacta     1799

aagtatatct ttaattctgg gagaaatgag ataaaagatg tacttgtgac cattgtaaca     1859

atagcacaaa t                                                          1870


<210>  24
<211>  472
<212>  PRT
<213>  Homo sapiens - CD36 antigen

<400>  24

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  25
<211>  2419
<212>  DNA
<213>  Mus musculus - RIKEN cDNA 9030625A04 gene


<220>
<221>  CDS
<222>  (352)..(1644)

<400>  25
gcggtgaggc gggcggaccg gccggccggt gactttggga gccactgggg ttcgagcgcc       60

gagcctgcag ctcacgcccc agctcgcggc cgccgaggag agcgcgggaa gcagccctgc      120

gcacttggga ggcagaggca gaggcaagca ggtgtctgag gtcgaagcca gcctggtcta      180

catagctagt tccaggactg ctggggctgt tagacagaga agctctgcct cgaatccctg      240

tcccaaccgc aaccccaaag aagattggct gctgatactg ctcaacttaa tatcctaaag      300

ctgctatggc ataaaaagtc tttggggcaa aaaagactgc ctgattgaag a atg gca       357
                                                         Met Ala          
                                                         1                

gaa gca gtc ttg att gat ctc tct ggt tta caa ttg aat gca cag aaa        405
Glu Ala Val Leu Ile Asp Leu Ser Gly Leu Gln Leu Asn Ala Gln Lys           
        5                   10                  15                        

aac tgc cat gag acc tta ctg gag aca ctg gat ggt att cac tac cac        453
Asn Cys His Glu Thr Leu Leu Glu Thr Leu Asp Gly Ile His Tyr His           
    20                  25                  30                            

cac gct ccc aag gcc aag ttc ctt tgc ata ata tgt tgc aga aat gcc        501
His Ala Pro Lys Ala Lys Phe Leu Cys Ile Ile Cys Cys Arg Asn Ala           
35                  40                  45                  50            

agc aag gaa aag gat ggg gag tat ggc ctc tgt gaa ttg gaa gca gga        549
Ser Lys Glu Lys Asp Gly Glu Tyr Gly Leu Cys Glu Leu Glu Ala Gly           
                55                  60                  65                

aat ggc ttt tca cgt ctc gcg gga aaa ttc gag act gtt agc cat ccc        597
Asn Gly Phe Ser Arg Leu Ala Gly Lys Phe Glu Thr Val Ser His Pro           
            70                  75                  80                    

tgc ctg gct gcc tct ttg tat aca att aaa caa aaa att gat gaa gaa        645
Cys Leu Ala Ala Ser Leu Tyr Thr Ile Lys Gln Lys Ile Asp Glu Glu           
        85                  90                  95                        

aat ctg agc tgc att aag gtg att gtc ccc gag cac agg aaa ctg tta        693
Asn Leu Ser Cys Ile Lys Val Ile Val Pro Glu His Arg Lys Leu Leu           
    100                 105                 110                           

atg aag gct tac gtt ggt caa ctc ttc acc gag gtg tat gag ttt gag        741
Met Lys Ala Tyr Val Gly Gln Leu Phe Thr Glu Val Tyr Glu Phe Glu           
115                 120                 125                 130           

ttt gaa gat cta cag gga gct tgg agg gat agc ctt ttg aaa cca tcc        789
Phe Glu Asp Leu Gln Gly Ala Trp Arg Asp Ser Leu Leu Lys Pro Ser           
                135                 140                 145               

act gga ata aac gtg acc aca act caa gaa cta gaa gac atc cag cat        837
Thr Gly Ile Asn Val Thr Thr Thr Gln Glu Leu Glu Asp Ile Gln His           
            150                 155                 160                   

gaa ata gaa aca tac ttg aga agc ctg cca gcg ctg aaa ggg gac cta        885
Glu Ile Glu Thr Tyr Leu Arg Ser Leu Pro Ala Leu Lys Gly Asp Leu           
        165                 170                 175                       

act att gtc aca tct cct ctg atc cca gac aac ttc ctg cat gga ttt        933
Thr Ile Val Thr Ser Pro Leu Ile Pro Asp Asn Phe Leu His Gly Phe           
    180                 185                 190                           

acc aca cgg aca ggg ggc ata tct tcc gta ccc act ctc agc tcc ctc        981
Thr Thr Arg Thr Gly Gly Ile Ser Ser Val Pro Thr Leu Ser Ser Leu           
195                 200                 205                 210           

aat ctt ttc agt agt tcc aaa agg aga gat ccc aaa gtg gtt gtt caa       1029
Asn Leu Phe Ser Ser Ser Lys Arg Arg Asp Pro Lys Val Val Val Gln           
                215                 220                 225               

gaa aat gtt cgc agg ttg gca aat gct gcc gga ttt aac gca gag aaa       1077
Glu Asn Val Arg Arg Leu Ala Asn Ala Ala Gly Phe Asn Ala Glu Lys           
            230                 235                 240                   

ttt tac cga ata aag act gat cac gcc agt gaa gtg tgg gtt atg ggg       1125
Phe Tyr Arg Ile Lys Thr Asp His Ala Ser Glu Val Trp Val Met Gly           
        245                 250                 255                       

aag aag gag cct gaa tct tac gat ggg atc gtc aca aat cag aga gga       1173
Lys Lys Glu Pro Glu Ser Tyr Asp Gly Ile Val Thr Asn Gln Arg Gly           
    260                 265                 270                           

gtc aca atc act gct ctt ggc gcc gac tgt ata ccc atc gtc ttc gca       1221
Val Thr Ile Thr Ala Leu Gly Ala Asp Cys Ile Pro Ile Val Phe Ala           
275                 280                 285                 290           

gat cct gtg aaa aag gca tgt ggg gtt gct cac tcc ggc tgg aaa ggt       1269
Asp Pro Val Lys Lys Ala Cys Gly Val Ala His Ser Gly Trp Lys Gly           
                295                 300                 305               

aca ttg ttg ggt gtg gct atg gct act gtg aat gct atg ata gca gaa       1317
Thr Leu Leu Gly Val Ala Met Ala Thr Val Asn Ala Met Ile Ala Glu           
            310                 315                 320                   

tat ggc tgt gat gtg gaa gac att att gtt gtt ctg gga ccg tca gtg       1365
Tyr Gly Cys Asp Val Glu Asp Ile Ile Val Val Leu Gly Pro Ser Val           
        325                 330                 335                       

ggt tct tgc tgc ttc act ctt ccc aaa gaa tca gca gtc tcc ttt cac       1413
Gly Ser Cys Cys Phe Thr Leu Pro Lys Glu Ser Ala Val Ser Phe His           
    340                 345                 350                           

agt ctt cat cct tca tgt gtg aga cac ttt gac tca ccg aga ccc tac       1461
Ser Leu His Pro Ser Cys Val Arg His Phe Asp Ser Pro Arg Pro Tyr           
355                 360                 365                 370           

gtt gac atc cga aaa gcc acc agg att ctt cta gaa aga gga gga att       1509
Val Asp Ile Arg Lys Ala Thr Arg Ile Leu Leu Glu Arg Gly Gly Ile           
                375                 380                 385               

ctt cca cag aac att caa gac cag aag gaa gat ctt gac ctc tgc acg       1557
Leu Pro Gln Asn Ile Gln Asp Gln Lys Glu Asp Leu Asp Leu Cys Thr           
            390                 395                 400                   

tcc tgc cat cct gag aag ttt ttc tcc cat gtc cgc gat ggc ctt aac       1605
Ser Cys His Pro Glu Lys Phe Phe Ser His Val Arg Asp Gly Leu Asn           
        405                 410                 415                       

ttc ggt aca cag att ggc ttc ata tcc ctt aga gaa tga ggttcttggc        1654
Phe Gly Thr Gln Ile Gly Phe Ile Ser Leu Arg Glu                           
    420                 425                 430                           

tggagttttg cataaaggat gtttcctgca tccttccaca ctggctgcaa aagaaaatac     1714

ttagctttct gatttatata aaaccatgag gattacaaaa gataattcat ctttagggta     1774

tgctcttact gttacccaaa gcccagtgat cttggtctaa ttcttatgac aactgatcaa     1834

aaaacccaat gtgatgtcat tcctgaaggt cgttctctgt atttgtctat aaatcaaggc     1894

cagggctgtt cagttaagta tttggtagat gccaactttt gtttaggcat ggagcccagc     1954

acagggaatt gaaatgaagt cagctttctc atttgaagca gatgcagctg ggagatacct     2014

gttcccttag gtttccttat ggcattctca agcgccatgt ttttgctgat ccttccctcc     2074

ccttccctgt cccctgtgtc cccttccact cccggtagcc cctctttcct gtctcatggg     2134

ctttaatact tctcccttgc tcagtcctct ctttatgttc cctttctagt atcaacacct     2194

atatccacac ctatgaccac aaatttacag atccatatat atgtatgttt acataaacag     2254

taaaagttag aatttatatt tatatataag aaaaaataca tgcagtgttt gttattccca     2314

gtctggatta ttttggtcag cataaaataa ttccagatct ctcaattttc ctacaagttt     2374

gataacttca ttatggctaa ataaaatatt gtgtgtatga actgc                     2419


<210>  26
<211>  430
<212>  PRT
<213>  Mus musculus - RIKEN cDNA 9030625A04 gene

<400>  26

Met Ala Glu Ala Val Leu Ile Asp Leu Ser Gly Leu Gln Leu Asn Ala 
1               5                   10                  15      


Gln Lys Asn Cys His Glu Thr Leu Leu Glu Thr Leu Asp Gly Ile His 
            20                  25                  30          


Tyr His His Ala Pro Lys Ala Lys Phe Leu Cys Ile Ile Cys Cys Arg 
        35                  40                  45              


Asn Ala Ser Lys Glu Lys Asp Gly Glu Tyr Gly Leu Cys Glu Leu Glu 
    50                  55                  60                  


Ala Gly Asn Gly Phe Ser Arg Leu Ala Gly Lys Phe Glu Thr Val Ser 
65                  70                  75                  80  


His Pro Cys Leu Ala Ala Ser Leu Tyr Thr Ile Lys Gln Lys Ile Asp 
                85                  90                  95      


Glu Glu Asn Leu Ser Cys Ile Lys Val Ile Val Pro Glu His Arg Lys 
            100                 105                 110         


Leu Leu Met Lys Ala Tyr Val Gly Gln Leu Phe Thr Glu Val Tyr Glu 
        115                 120                 125             


Phe Glu Phe Glu Asp Leu Gln Gly Ala Trp Arg Asp Ser Leu Leu Lys 
    130                 135                 140                 


Pro Ser Thr Gly Ile Asn Val Thr Thr Thr Gln Glu Leu Glu Asp Ile 
145                 150                 155                 160 


Gln His Glu Ile Glu Thr Tyr Leu Arg Ser Leu Pro Ala Leu Lys Gly 
                165                 170                 175     


Asp Leu Thr Ile Val Thr Ser Pro Leu Ile Pro Asp Asn Phe Leu His 
            180                 185                 190         


Gly Phe Thr Thr Arg Thr Gly Gly Ile Ser Ser Val Pro Thr Leu Ser 
        195                 200                 205             


Ser Leu Asn Leu Phe Ser Ser Ser Lys Arg Arg Asp Pro Lys Val Val 
    210                 215                 220                 


Val Gln Glu Asn Val Arg Arg Leu Ala Asn Ala Ala Gly Phe Asn Ala 
225                 230                 235                 240 


Glu Lys Phe Tyr Arg Ile Lys Thr Asp His Ala Ser Glu Val Trp Val 
                245                 250                 255     


Met Gly Lys Lys Glu Pro Glu Ser Tyr Asp Gly Ile Val Thr Asn Gln 
            260                 265                 270         


Arg Gly Val Thr Ile Thr Ala Leu Gly Ala Asp Cys Ile Pro Ile Val 
        275                 280                 285             


Phe Ala Asp Pro Val Lys Lys Ala Cys Gly Val Ala His Ser Gly Trp 
    290                 295                 300                 


Lys Gly Thr Leu Leu Gly Val Ala Met Ala Thr Val Asn Ala Met Ile 
305                 310                 315                 320 


Ala Glu Tyr Gly Cys Asp Val Glu Asp Ile Ile Val Val Leu Gly Pro 
                325                 330                 335     


Ser Val Gly Ser Cys Cys Phe Thr Leu Pro Lys Glu Ser Ala Val Ser 
            340                 345                 350         


Phe His Ser Leu His Pro Ser Cys Val Arg His Phe Asp Ser Pro Arg 
        355                 360                 365             


Pro Tyr Val Asp Ile Arg Lys Ala Thr Arg Ile Leu Leu Glu Arg Gly 
    370                 375                 380                 


Gly Ile Leu Pro Gln Asn Ile Gln Asp Gln Lys Glu Asp Leu Asp Leu 
385                 390                 395                 400 


Cys Thr Ser Cys His Pro Glu Lys Phe Phe Ser His Val Arg Asp Gly 
                405                 410                 415     


Leu Asn Phe Gly Thr Gln Ile Gly Phe Ile Ser Leu Arg Glu 
            420                 425                 430 


<210>  27
<211>  2135
<212>  DNA
<213>  Mus musculus - Prostaglandin-endoperoxide synthase 2


<220>
<221>  CDS
<222>  (97)..(1782)

<400>  27
aagaggtaat ccagactctg ctcacgaagg aactcagcac tgcatcctgc cagctccacc       60

gccaccacta ctgccacctc cgctgccacc tctgcg atg ctc ttc cga gct gtg        114
                                        Met Leu Phe Arg Ala Val           
                                        1               5                 

ctg ctc tgc gct gcc ctg ggg ctc agc cag gca gca aat cct tgc tgt        162
Leu Leu Cys Ala Ala Leu Gly Leu Ser Gln Ala Ala Asn Pro Cys Cys           
            10                  15                  20                    

tcc aat cca tgt caa aac cgt ggg gaa tgt atg agc aca gga ttt gac        210
Ser Asn Pro Cys Gln Asn Arg Gly Glu Cys Met Ser Thr Gly Phe Asp           
        25                  30                  35                        

cag tat aag tgt gac tgt acc cgg act gga ttc tat ggt gaa aac tgt        258
Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly Phe Tyr Gly Glu Asn Cys           
    40                  45                  50                            

act aca cct gaa ttt ctg aca aga atc aaa tta ctg ctg aag ccc acc        306
Thr Thr Pro Glu Phe Leu Thr Arg Ile Lys Leu Leu Leu Lys Pro Thr           
55                  60                  65                  70            

cca aac aca gtg cac tac atc ctg acc cac ttc aag gga gtc tgg aac        354
Pro Asn Thr Val His Tyr Ile Leu Thr His Phe Lys Gly Val Trp Asn           
                75                  80                  85                

att gtg aac aac atc ccc ctc ctg cga agt tta atc atg aaa tat gtg        402
Ile Val Asn Asn Ile Pro Leu Leu Arg Ser Leu Ile Met Lys Tyr Val           
            90                  95                  100                   

ctg aca tcc aga tca tat ttg att gac agt cca cct act tac aat gtg        450
Leu Thr Ser Arg Ser Tyr Leu Ile Asp Ser Pro Pro Thr Tyr Asn Val           
        105                 110                 115                       

cac tat ggt tac aaa agc tgg gaa gcc ttc tcc aac ctc tcc tac tac        498
His Tyr Gly Tyr Lys Ser Trp Glu Ala Phe Ser Asn Leu Ser Tyr Tyr           
    120                 125                 130                           

acc agg gcc ctt cct ccc gta gca gat gac tgc cca act ccc atg ggt        546
Thr Arg Ala Leu Pro Pro Val Ala Asp Asp Cys Pro Thr Pro Met Gly           
135                 140                 145                 150           

gtg aag gga aat aag gag ctt cct gat tca aaa gaa gtg ctg gaa aag        594
Val Lys Gly Asn Lys Glu Leu Pro Asp Ser Lys Glu Val Leu Glu Lys           
                155                 160                 165               

gtt ctt cta cgg aga gag ttc atc cct gac ccc caa ggc tca aat atg        642
Val Leu Leu Arg Arg Glu Phe Ile Pro Asp Pro Gln Gly Ser Asn Met           
            170                 175                 180                   

atg ttt gca ttc ttt gcc cag cac ttc acc cat cag ttt ttc aag aca        690
Met Phe Ala Phe Phe Ala Gln His Phe Thr His Gln Phe Phe Lys Thr           
        185                 190                 195                       

gat cat aag cga gga cct ggg ttc acc cga gga ctg ggc cat gga gtg        738
Asp His Lys Arg Gly Pro Gly Phe Thr Arg Gly Leu Gly His Gly Val           
    200                 205                 210                           

gac tta aat cac att tat ggt gaa act ctg gac aga caa cat aaa ctg        786
Asp Leu Asn His Ile Tyr Gly Glu Thr Leu Asp Arg Gln His Lys Leu           
215                 220                 225                 230           

cgc ctt ttc aag gat gga aaa ttg aaa tat cag gtc att ggt gga gag        834
Arg Leu Phe Lys Asp Gly Lys Leu Lys Tyr Gln Val Ile Gly Gly Glu           
                235                 240                 245               

gtg tat ccc ccc aca gtc aaa gac act cag gta gag atg atc tac cct        882
Val Tyr Pro Pro Thr Val Lys Asp Thr Gln Val Glu Met Ile Tyr Pro           
            250                 255                 260                   

cct cac atc cct gag aac ctg cag ttt gct gtg ggg cag gaa gtc ttt        930
Pro His Ile Pro Glu Asn Leu Gln Phe Ala Val Gly Gln Glu Val Phe           
        265                 270                 275                       

ggt ctg gtg cct ggt ctg atg atg tat gcc acc atc tgg ctt cgg gag        978
Gly Leu Val Pro Gly Leu Met Met Tyr Ala Thr Ile Trp Leu Arg Glu           
    280                 285                 290                           

cac aac aga gtg tgc gac ata ctc aag ttt gac cca gag ctc ctt ttc       1026
His Asn Arg Val Cys Asp Ile Leu Lys Phe Asp Pro Glu Leu Leu Phe           
295                 300                 305                 310           

aac cag cag ttc cag tat cag aac cgc att gcc tct gaa ttc aac aca       1074
Asn Gln Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ser Glu Phe Asn Thr           
                315                 320                 325               

ctc tat cac tgg cac ccc ctg ctg ccc gac acc ttc aac att gaa gac       1122
Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Asn Ile Glu Asp           
            330                 335                 340                   

cag gag tac agc ttc aaa cag ttt ctc tac aac aac tcc atc ctc ctg       1170
Gln Glu Tyr Ser Phe Lys Gln Phe Leu Tyr Asn Asn Ser Ile Leu Leu           
        345                 350                 355                       

gaa cat gga ctc act cag ttt gtt gag tca ttc acc aga cag att gct       1218
Glu His Gly Leu Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile Ala           
    360                 365                 370                           

ggc cgg gtt gct ggg gga aga aat gtg cca att gct gta caa gca gtg       1266
Gly Arg Val Ala Gly Gly Arg Asn Val Pro Ile Ala Val Gln Ala Val           
375                 380                 385                 390           

gca aag gcc tcc att gac cag agc aga gag atg aaa tac cag tct ctc       1314
Ala Lys Ala Ser Ile Asp Gln Ser Arg Glu Met Lys Tyr Gln Ser Leu           
                395                 400                 405               

aat gag tac cgc aaa cgc ttc tcc ctg aag ccg tac aca tca ttt gaa       1362
Asn Glu Tyr Arg Lys Arg Phe Ser Leu Lys Pro Tyr Thr Ser Phe Glu           
            410                 415                 420                   

gaa ctt aca gga gag aag gaa atg gct gca gaa ttg aaa gcc ctc tac       1410
Glu Leu Thr Gly Glu Lys Glu Met Ala Ala Glu Leu Lys Ala Leu Tyr           
        425                 430                 435                       

agt gac atc gat gtc atg gaa ctg tac cct gcc ctg ctg gtg gaa aaa       1458
Ser Asp Ile Asp Val Met Glu Leu Tyr Pro Ala Leu Leu Val Glu Lys           
    440                 445                 450                           

cct cgt cca gat gct atc ttt ggg gag acc atg gta gag ctt gga gca       1506
Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Leu Gly Ala           
455                 460                 465                 470           

cca ttc tcc ttg aaa gga ctt atg gga aat ccc atc tgt tct cct caa       1554
Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Pro Ile Cys Ser Pro Gln           
                475                 480                 485               

tac tgg aag ccg agc acc ttt gga ggc gaa gtg ggt ttt aag atc atc       1602
Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Lys Ile Ile           
            490                 495                 500                   

aat act gcc tca att cag tct ctc atc tgc aat aat gtg aag ggg tgt       1650
Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly Cys           
        505                 510                 515                       

ccc ttc act tct ttc aat gtg caa gat cca cag cct acc aaa aca gcc       1698
Pro Phe Thr Ser Phe Asn Val Gln Asp Pro Gln Pro Thr Lys Thr Ala           
    520                 525                 530                           

acc atc aat gca agt gcc tcc cac tcc aga cta gat gac att aac cct       1746
Thr Ile Asn Ala Ser Ala Ser His Ser Arg Leu Asp Asp Ile Asn Pro           
535                 540                 545                 550           

aca gta cta atc aaa agg cgt tca act gag ctg taa aagtctactg            1792
Thr Val Leu Ile Lys Arg Arg Ser Thr Glu Leu                               
                555                 560                                   

accatattta tttatttatg tgaagaattt aatttaatta tttaatattt atactgaatt     1852

ttttttcatg taacatcttc cataacagaa ggcaatgttc ttgaacaatg ttacatttgt     1912

gaagattccc tccggtgttt gtcctttaaa tatgtgttac ctgaaactga aaggaaatca     1972

gcattcattc ctctacataa gccagtgaga agggaaatga attttgatat ctttatactt     2032

gaatttcaga tcatgattag cttaacaaga accaaggaaa aatgtatgaa tatgtgagtg     2092

ttgttacaag atgaaaaatg ctgcaggtat caaaaaaaaa aaa                       2135


<210>  28
<211>  561
<212>  PRT
<213>  Mus musculus - Prostaglandin-endoperoxide synthase 2

<400>  28

Met Leu Phe Arg Ala Val Leu Leu Cys Ala Ala Leu Gly Leu Ser Gln 
1               5                   10                  15      


Ala Ala Asn Pro Cys Cys Ser Asn Pro Cys Gln Asn Arg Gly Glu Cys 
            20                  25                  30          


Met Ser Thr Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly 
        35                  40                  45              


Phe Tyr Gly Glu Asn Cys Thr Thr Pro Glu Phe Leu Thr Arg Ile Lys 
    50                  55                  60                  


Leu Leu Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His 
65                  70                  75                  80  


Phe Lys Gly Val Trp Asn Ile Val Asn Asn Ile Pro Leu Leu Arg Ser 
                85                  90                  95      


Leu Ile Met Lys Tyr Val Leu Thr Ser Arg Ser Tyr Leu Ile Asp Ser 
            100                 105                 110         


Pro Pro Thr Tyr Asn Val His Tyr Gly Tyr Lys Ser Trp Glu Ala Phe 
        115                 120                 125             


Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Ala Asp Asp 
    130                 135                 140                 


Cys Pro Thr Pro Met Gly Val Lys Gly Asn Lys Glu Leu Pro Asp Ser 
145                 150                 155                 160 


Lys Glu Val Leu Glu Lys Val Leu Leu Arg Arg Glu Phe Ile Pro Asp 
                165                 170                 175     


Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr 
            180                 185                 190         


His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Gly Phe Thr Arg 
        195                 200                 205             


Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu 
    210                 215                 220                 


Asp Arg Gln His Lys Leu Arg Leu Phe Lys Asp Gly Lys Leu Lys Tyr 
225                 230                 235                 240 


Gln Val Ile Gly Gly Glu Val Tyr Pro Pro Thr Val Lys Asp Thr Gln 
                245                 250                 255     


Val Glu Met Ile Tyr Pro Pro His Ile Pro Glu Asn Leu Gln Phe Ala 
            260                 265                 270         


Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala 
        275                 280                 285             


Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Ile Leu Lys Phe 
    290                 295                 300                 


Asp Pro Glu Leu Leu Phe Asn Gln Gln Phe Gln Tyr Gln Asn Arg Ile 
305                 310                 315                 320 


Ala Ser Glu Phe Asn Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp 
                325                 330                 335     


Thr Phe Asn Ile Glu Asp Gln Glu Tyr Ser Phe Lys Gln Phe Leu Tyr 
            340                 345                 350         


Asn Asn Ser Ile Leu Leu Glu His Gly Leu Thr Gln Phe Val Glu Ser 
        355                 360                 365             


Phe Thr Arg Gln Ile Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro 
    370                 375                 380                 


Ile Ala Val Gln Ala Val Ala Lys Ala Ser Ile Asp Gln Ser Arg Glu 
385                 390                 395                 400 


Met Lys Tyr Gln Ser Leu Asn Glu Tyr Arg Lys Arg Phe Ser Leu Lys 
                405                 410                 415     


Pro Tyr Thr Ser Phe Glu Glu Leu Thr Gly Glu Lys Glu Met Ala Ala 
            420                 425                 430         


Glu Leu Lys Ala Leu Tyr Ser Asp Ile Asp Val Met Glu Leu Tyr Pro 
        435                 440                 445             


Ala Leu Leu Val Glu Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr 
    450                 455                 460                 


Met Val Glu Leu Gly Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn 
465                 470                 475                 480 


Pro Ile Cys Ser Pro Gln Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu 
                485                 490                 495     


Val Gly Phe Lys Ile Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys 
            500                 505                 510         


Asn Asn Val Lys Gly Cys Pro Phe Thr Ser Phe Asn Val Gln Asp Pro 
        515                 520                 525             


Gln Pro Thr Lys Thr Ala Thr Ile Asn Ala Ser Ala Ser His Ser Arg 
    530                 535                 540                 


Leu Asp Asp Ile Asn Pro Thr Val Leu Ile Lys Arg Arg Ser Thr Glu 
545                 550                 555                 560 


Leu 
    


<210>  29
<211>  3394
<212>  DNA
<213>  Homo sapiens - Prostaglandin-endoperoxide synthase 2


<220>
<221>  CDS
<222>  (121)..(1935)

<400>  29
cttgcagtga gcgtcaggag cacgtccagg aactcctcag cagcgcctcc ttcagctcca       60

cagccagacg ccctcagaca gcaaagccta cccccgcgcc gcgccctgcc cgccgctgcg      120

atg ctc gcc cgc gcc ctg ctg ctg tgc gcg gtc ctg gcg ctc agc cat        168
Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His           
1               5                   10                  15                

aca gca aat cct tgc tgt tcc cac cca tgt caa aac cga ggt gta tgt        216
Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys           
            20                  25                  30                    

atg agt gtg gga ttt gac cag tat aag tgc gat tgt acc cgg aca gga        264
Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly           
        35                  40                  45                        

ttc tat gga gaa aac tgc tca aca ccg gaa ttt ttg aca aga ata aaa        312
Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys           
    50                  55                  60                            

tta ttt ctg aaa ccc act cca aac aca gtg cac tac ata ctt acc cac        360
Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His           
65                  70                  75                  80            

ttc aag gga ttt tgg aac gtt gtg aat aac att ccc ttc ctt cga aat        408
Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn           
                85                  90                  95                

gca att atg agt tat gtg ttg aca tcc aga tca cat ttg att gac agt        456
Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser           
            100                 105                 110                   

cca cca act tac aat gct gac tat ggc tac aaa agc tgg gaa gcc ttc        504
Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe           
        115                 120                 125                       

tct aac ctc tcc tat tat act aga gcc ctt cct cct gtg cct gat gat        552
Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp           
    130                 135                 140                           

tgc ccg act ccc ttg ggt gtc aaa ggt aaa aag cag ctt cct gat tca        600
Cys Pro Thr Pro Leu Gly Val Lys Gly Lys Lys Gln Leu Pro Asp Ser           
145                 150                 155                 160           

aat gag att gtg gaa aaa ttg ctt cta aga aga aag ttc atc cct gat        648
Asn Glu Ile Val Glu Lys Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp           
                165                 170                 175               

ccc cag ggc tca aac atg atg ttt gca ttc ttt gcc cag cac ttc acg        696
Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr           
            180                 185                 190                   

cat cag ttt ttc aag aca gat cat aag cga ggg cca gct ttc acc aac        744
His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Ala Phe Thr Asn           
        195                 200                 205                       

ggg ctg ggc cat ggg gtg gac tta aat cat att tac ggt gaa act ctg        792
Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu           
    210                 215                 220                           

gct aga cag cgt aaa ctg cgc ctt ttc aag gat gga aaa atg aaa tat        840
Ala Arg Gln Arg Lys Leu Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr           
225                 230                 235                 240           

cag ata att gat gga gag atg tat cct ccc aca gtc aaa gat act cag        888
Gln Ile Ile Asp Gly Glu Met Tyr Pro Pro Thr Val Lys Asp Thr Gln           
                245                 250                 255               

gca gag atg atc tac cct cct caa gtc cct gag cat cta cgg ttt gct        936
Ala Glu Met Ile Tyr Pro Pro Gln Val Pro Glu His Leu Arg Phe Ala           
            260                 265                 270                   

gtg ggg cag gag gtc ttt ggt ctg gtg cct ggt ctg atg atg tat gcc        984
Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala           
        275                 280                 285                       

aca atc tgg ctg cgg gaa cac aac aga gta tgc gat gtg ctt aaa cag       1032
Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Val Leu Lys Gln           
    290                 295                 300                           

gag cat cct gaa tgg ggt gat gag cag ttg ttc cag aca agc agg cta       1080
Glu His Pro Glu Trp Gly Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu           
305                 310                 315                 320           

ata ctg ata gga gag act att aag att gtg att gaa gat tat gtg caa       1128
Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Asp Tyr Val Gln           
                325                 330                 335               

cac ttg agt ggc tat cac ttc aaa ctg aaa ttt gac cca gaa cta ctt       1176
His Leu Ser Gly Tyr His Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu           
            340                 345                 350                   

ttc aac aaa caa ttc cag tac caa aat cgt att gct gct gaa ttt aac       1224
Phe Asn Lys Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn           
        355                 360                 365                       

acc ctc tat cac tgg cat ccc ctt ctg cct gac acc ttt caa att cat       1272
Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Gln Ile His           
    370                 375                 380                           

gac cag aaa tac aac tat caa cag ttt atc tac aac aac tct ata ttg       1320
Asp Gln Lys Tyr Asn Tyr Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu           
385                 390                 395                 400           

ctg gaa cat gga att acc cag ttt gtt gaa tca ttc acc agg caa att       1368
Leu Glu His Gly Ile Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile           
                405                 410                 415               

gct ggc agg gtt gct ggt ggt agg aat gtt cca ccc gca gta cag aaa       1416
Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro Pro Ala Val Gln Lys           
            420                 425                 430                   

gta tca cag gct tcc att gac cag agc agg cag atg aaa tac cag tct       1464
Val Ser Gln Ala Ser Ile Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser           
        435                 440                 445                       

ttt aat gag tac cgc aaa cgc ttt atg ctg aag ccc tat gaa tca ttt       1512
Phe Asn Glu Tyr Arg Lys Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe           
    450                 455                 460                           

gaa gaa ctt aca gga gaa aag gaa atg tct gca gag ttg gaa gca ctc       1560
Glu Glu Leu Thr Gly Glu Lys Glu Met Ser Ala Glu Leu Glu Ala Leu           
465                 470                 475                 480           

tat ggt gac atc gat gct gtg gag ctg tat cct gcc ctt ctg gta gaa       1608
Tyr Gly Asp Ile Asp Ala Val Glu Leu Tyr Pro Ala Leu Leu Val Glu           
                485                 490                 495               

aag cct cgg cca gat gcc atc ttt ggt gaa acc atg gta gaa gtt gga       1656
Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Val Gly           
            500                 505                 510                   

gca cca ttc tcc ttg aaa gga ctt atg ggt aat gtt ata tgt tct cct       1704
Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Val Ile Cys Ser Pro           
        515                 520                 525                       

gcc tac tgg aag cca agc act ttt ggt gga gaa gtg ggt ttt caa atc       1752
Ala Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Gln Ile           
    530                 535                 540                           

atc aac act gcc tca att cag tct ctc atc tgc aat aac gtg aag ggc       1800
Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly           
545                 550                 555                 560           

tgt ccc ttt act tca ttc agt gtt cca gat cca gag ctc att aaa aca       1848
Cys Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile Lys Thr           
                565                 570                 575               

gtc acc atc aat gca agt tct tcc cgc tcc gga cta gat gat atc aat       1896
Val Thr Ile Asn Ala Ser Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn           
            580                 585                 590                   

ccc aca gta cta cta aaa gaa cgt tcg act gaa ctg tag aagtctaatg        1945
Pro Thr Val Leu Leu Lys Glu Arg Ser Thr Glu Leu                           
        595                 600                                           

atcatattta tttatttata tgaaccatgt ctattaattt aattatttaa taatatttat     2005

attaaactcc ttatgttact taacatcttc tgtaacagaa gtcagtactc ctgttgcgga     2065

gaaaggagtc atacttgtga agacttttat gtcactactc taaagatttt gctgttgctg     2125

ttaagtttgg aaaacagttt ttattctgtt ttataaacca gagagaaatg agttttgacg     2185

tctttttact tgaatttcaa cttatattat aagaacgaaa gtaaagatgt ttgaatactt     2245

aaacactgtc acaagatggc aaaatgctga aagtttttac actgtcgatg tttccaatgc     2305

atcttccatg atgcattaga agtaactaat gtttgaaatt ttaaagtact tttggtcatt     2365

tttctgtcat caaacaaaaa caggtatcag tgcattatta aatgaatatt taaattagac     2425

attaccagta atttcatgtc tactttttaa aatcagcaat gaaacaataa tttgaaattt     2485

ctaaattcat agggtagaat cacctgtaaa agcttgtttg atttcttaaa gttattaaac     2545

ttgtacatat accaaaaaga agctgtcttg gatttaaatc tgtaaaatca gtagaaattt     2605

tactacaatt gcttgttaaa atattttata agtgatgttc ctttttcacc aagagtataa     2665

acctttttag tgtgactgtt aaaacttcct tttaaatcaa aatgccaaat ttattaaggt     2725

ggtggagcca ctgcagtgtt atcttaaaat aagaatattt tgttgagata ttccagaatt     2785

tgtttatatg gctggtaaca tgtaaaatct atatcagcaa aagggtctac ctttaaaata     2845

agcaataaca aagaagaaaa ccaaattatt gttcaaattt aggtttaaac ttttgaagca     2905

aacttttttt tatccttgtg cactgcaggc ctggtactca gattttgcta tgaggttaat     2965

gaagtaccaa gctgtgcttg aataacgata tgttttctca gattttctgt tgtacagttt     3025

aatttagcag tccatatcac attgcaaaag tagcaatgac ctcataaaat acctcttcaa     3085

aatgcttaaa ttcatttcac acattaattt tatctcagtc ttgaagccaa ttcagtaggt     3145

gcattggaat caagcctggc tacctgcatg ctgttccttt tcttttcttc ttttagccat     3205

tttgctaaga gacacagtct tctcatcact tcgtttctcc tattttgttt tactagtctt     3265

aagatcagag ttcactttct ttggactctg cctatatttt cttacctgaa cttttgcaag     3325

ttttcaggta aacctcagct caggactgct atttagctcc tcttaagaag attaaaaaaa     3385

aaaaaaaaa                                                             3394


<210>  30
<211>  604
<212>  PRT
<213>  Homo sapiens - Prostaglandin-endoperoxide synthase 2

<400>  30

Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His 
1               5                   10                  15      


Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys 
            20                  25                  30          


Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly 
        35                  40                  45              


Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys 
    50                  55                  60                  


Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His 
65                  70                  75                  80  


Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn 
                85                  90                  95      


Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser 
            100                 105                 110         


Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe 
        115                 120                 125             


Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp 
    130                 135                 140                 


Cys Pro Thr Pro Leu Gly Val Lys Gly Lys Lys Gln Leu Pro Asp Ser 
145                 150                 155                 160 


Asn Glu Ile Val Glu Lys Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp 
                165                 170                 175     


Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr 
            180                 185                 190         


His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Ala Phe Thr Asn 
        195                 200                 205             


Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu 
    210                 215                 220                 


Ala Arg Gln Arg Lys Leu Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr 
225                 230                 235                 240 


Gln Ile Ile Asp Gly Glu Met Tyr Pro Pro Thr Val Lys Asp Thr Gln 
                245                 250                 255     


Ala Glu Met Ile Tyr Pro Pro Gln Val Pro Glu His Leu Arg Phe Ala 
            260                 265                 270         


Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala 
        275                 280                 285             


Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Val Leu Lys Gln 
    290                 295                 300                 


Glu His Pro Glu Trp Gly Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu 
305                 310                 315                 320 


Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Asp Tyr Val Gln 
                325                 330                 335     


His Leu Ser Gly Tyr His Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu 
            340                 345                 350         


Phe Asn Lys Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn 
        355                 360                 365             


Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Gln Ile His 
    370                 375                 380                 


Asp Gln Lys Tyr Asn Tyr Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu 
385                 390                 395                 400 


Leu Glu His Gly Ile Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile 
                405                 410                 415     


Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro Pro Ala Val Gln Lys 
            420                 425                 430         


Val Ser Gln Ala Ser Ile Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser 
        435                 440                 445             


Phe Asn Glu Tyr Arg Lys Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe 
    450                 455                 460                 


Glu Glu Leu Thr Gly Glu Lys Glu Met Ser Ala Glu Leu Glu Ala Leu 
465                 470                 475                 480 


Tyr Gly Asp Ile Asp Ala Val Glu Leu Tyr Pro Ala Leu Leu Val Glu 
                485                 490                 495     


Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Val Gly 
            500                 505                 510         


Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Val Ile Cys Ser Pro 
        515                 520                 525             


Ala Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Gln Ile 
    530                 535                 540                 


Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly 
545                 550                 555                 560 


Cys Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile Lys Thr 
                565                 570                 575     


Val Thr Ile Asn Ala Ser Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn 
            580                 585                 590         


Pro Thr Val Leu Leu Lys Glu Arg Ser Thr Glu Leu 
        595                 600                 


<210>  31
<211>  1087
<212>  DNA
<213>  Mus musculus - RIKEN cDNA E030003E18 gene


<220>
<221>  CDS
<222>  (92)..(268)

<400>  31
ggagtctggt gctgactggt gaattcagaa gcaggaaaga gggacagagt ggattttaca       60

accagaataa agctgggaaa tgcccccgtg a atg gag cca aag aaa ggt tgg         112
                                   Met Glu Pro Lys Lys Gly Trp            
                                   1               5                      

agt ttg ggg tat ggt gtg tat ttg aag att caa act cca cgt ggt ctt        160
Ser Leu Gly Tyr Gly Val Tyr Leu Lys Ile Gln Thr Pro Arg Gly Leu           
        10                  15                  20                        

cag gag ctc aaa cac tct cac aca gaa cag aaa gga agt ctc caa aac        208
Gln Glu Leu Lys His Ser His Thr Glu Gln Lys Gly Ser Leu Gln Asn           
    25                  30                  35                            

gaa tgt gaa att gac aaa tca ccg cac tgc ttc agg acc cca gcc cat        256
Glu Cys Glu Ile Asp Lys Ser Pro His Cys Phe Arg Thr Pro Ala His           
40                  45                  50                  55            

gga atg ctg tga tcaacattca gagtcgatca tcctacatca attaccctaa            308
Gly Met Leu                                                               
                                                                          

tctaggaaat cccacagagc caggaccaaa gaacgtaaaa caaaaacaaa caaaacccag      368

cctgtgaaca ttagcaatag cacagtacct gagactacac agaagcctgg gaaagtcacc      428

tgtgaatgct gatgctctac agcatcacca tggtagagaa actacaaaag aagcttttga      488

ttctgaagct gagcctgatc ctccatgatc acaacattga agtctaatcc tctacatcaa      548

atattttaac tgtgagattt gtagacccaa cagattgcta ctcacctgtt gccatgactg      608

aagacttgaa aacattccaa aacacgttcc tgattgcata gccctaaaat tccttcctag      668

aagttcattc cgttcagtgg gttctataat ttctcttcta aattatactc tgtcacgtca      728

aacatcatga caattttcaa agtttactac ttccagaaac tttatttcta acaaatactt      788

actgagctaa tgtatgaggt gttataattg tatgacaaat ttaatacagc acatatttat      848

aatgacatcg aaacacatat atttttacca caaagcatat ttgaagaaaa ctttataaaa      908

taatattaac ctatagttcg tgcagttctc acctggatat tatatgctac tgtatgttag      968

ttttcaaagt gatgatctta acctataatg ttaatttgac cctttgatag aaaatttttt     1028

tctggtaatt acttgaattg tttatttggt tttaaaatta acaataaaga atcaaatat      1087


<210>  32
<211>  58
<212>  PRT
<213>  Mus musculus - RIKEN cDNA E030003E18 gene

<400>  32

Met Glu Pro Lys Lys Gly Trp Ser Leu Gly Tyr Gly Val Tyr Leu Lys 
1               5                   10                  15      


Ile Gln Thr Pro Arg Gly Leu Gln Glu Leu Lys His Ser His Thr Glu 
            20                  25                  30          


Gln Lys Gly Ser Leu Gln Asn Glu Cys Glu Ile Asp Lys Ser Pro His 
        35                  40                  45              


Cys Phe Arg Thr Pro Ala His Gly Met Leu 
    50                  55              


<210>  33
<211>  1751
<212>  DNA
<213>  Mus musculus - Tumor-associated calcium signal transducer 1


<220>
<221>  CDS
<222>  (122)..(1069)

<400>  33
gtccgctccc gcctcgccgc gcgcacagcg ctcagtccgt ccgccgccgc gcagcgcgac       60

tgtcctccga gccgtcccgc gccgcacctc cgcgagtcgc cctcgccgct ccgcgcgcag      120

c atg gcg ggt ccc cag gcc ctc gcg ttc ggg ctc ctg ctc gcg gtg gtc      169
  Met Ala Gly Pro Gln Ala Leu Ala Phe Gly Leu Leu Leu Ala Val Val         
  1               5                   10                  15              

aca gcg acg ctg gcc gcg gct cag aga gac tgt gtc tgt gac aac tac        217
Thr Ala Thr Leu Ala Ala Ala Gln Arg Asp Cys Val Cys Asp Asn Tyr           
            20                  25                  30                    

aag ctg gca aca agt tgc tct ctg aat gaa tat ggt gaa tgc cag tgt        265
Lys Leu Ala Thr Ser Cys Ser Leu Asn Glu Tyr Gly Glu Cys Gln Cys           
        35                  40                  45                        

act tcc tat ggt aca cag aat act gtc att tgc tcc aaa ctg gcg tct        313
Thr Ser Tyr Gly Thr Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ser           
    50                  55                  60                            

aaa tgc ttg gcg atg aaa gca gaa atg act cac agc aag tct ggg agg        361
Lys Cys Leu Ala Met Lys Ala Glu Met Thr His Ser Lys Ser Gly Arg           
65                  70                  75                  80            

agg ata aag ccc gaa ggg gcg atc cag aac aac gat ggg ctg tac gac        409
Arg Ile Lys Pro Glu Gly Ala Ile Gln Asn Asn Asp Gly Leu Tyr Asp           
                85                  90                  95                

ccc gac tgc gac gag cag ggg ctc ttc aaa gcc aag cag tgc aac ggc        457
Pro Asp Cys Asp Glu Gln Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly           
            100                 105                 110                   

acc gcc acg tgc tgg tgt gtc aac acc gcc gga gtc cga aga acc gac        505
Thr Ala Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp           
        115                 120                 125                       

aag gac acg gag atc acg tgc tcc gag cgc gtg agg acc tac tgg atc        553
Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile           
    130                 135                 140                           

atc att gaa cta aaa cac aaa gaa aga gaa agc ccc tac gac cat cag        601
Ile Ile Glu Leu Lys His Lys Glu Arg Glu Ser Pro Tyr Asp His Gln           
145                 150                 155                 160           

agc ttg cag act gcg ctt caa gag gcg ttc aca tct cga tat aag ctg        649
Ser Leu Gln Thr Ala Leu Gln Glu Ala Phe Thr Ser Arg Tyr Lys Leu           
                165                 170                 175               

aat cag aaa ttt atc aaa aac att atg tat gag aat aat gtt atc acc        697
Asn Gln Lys Phe Ile Lys Asn Ile Met Tyr Glu Asn Asn Val Ile Thr           
            180                 185                 190                   

att gat ctg atg caa aac tct tct cag aaa aca caa gac gac gtg gac        745
Ile Asp Leu Met Gln Asn Ser Ser Gln Lys Thr Gln Asp Asp Val Asp           
        195                 200                 205                       

ata gct gat gtg gct tac tat ttt gaa aaa gat gtg aag ggg gag tcc        793
Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser           
    210                 215                 220                           

ctg ttc cat tct tct aag agc atg gac ctg aga gtg aac gga gag ccg        841
Leu Phe His Ser Ser Lys Ser Met Asp Leu Arg Val Asn Gly Glu Pro           
225                 230                 235                 240           

ctc gat ctg gac ccc ggg cag act ctg att tac tac gtt gat gaa aag        889
Leu Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys           
                245                 250                 255               

gca ccc gag ttc tcc atg cag ggc ctc acg gcc ggg atc atc gct gtc        937
Ala Pro Glu Phe Ser Met Gln Gly Leu Thr Ala Gly Ile Ile Ala Val           
            260                 265                 270                   

att gtg gtg gtg tca tta gca gtc atc gcg ggg att gtt gtc ctg gtt        985
Ile Val Val Val Ser Leu Ala Val Ile Ala Gly Ile Val Val Leu Val           
        275                 280                 285                       

ata tct aca agg aag aaa tca gca aaa tat gag aag gct gag ata aag       1033
Ile Ser Thr Arg Lys Lys Ser Ala Lys Tyr Glu Lys Ala Glu Ile Lys           
    290                 295                 300                           

gag atg ggt gag atc cac aga gag ctt aat gcc tag ccgtgctgag            1079
Glu Met Gly Glu Ile His Arg Glu Leu Asn Ala                               
305                 310                 315                               

tgctgaactg aggaggggcc gcccgaccgg aagtggcaga agagctcgga ctgcagatgt     1139

ataaacctgg ggaagatgaa gacctgcgaa gggttactgc tttgatagtt actttgttag     1199

tttcacattt gtaacagtga aatttgtact cgtaaataca agcagctgga caccggcatt     1259

accgatcgta aaattagacg aacgtcttat aggtgcaggt ccagtgtggt actcagaact     1319

tagcctgcaa agttaagaga gttgatgctt attatgacag agtgtgcgtc gcaaacattc     1379

caacagtaga atgcggtgac tagtctcatt tttttttttt ttttgtgatt aaggctgccc     1439

ttctatatac ctgagtcttg tacataataa actttttttt aatgaaataa aacattttaa     1499

agtgagtttc taagtttgtt tgaatcaaat tttcctagca tgtgcataat taagataata     1559

gatgtctaaa tgctctggca ctgctaactg gtacaaacct gtaattctgt acttgggagg     1619

tagaggtagg agggttagcg cttccgaggt agctgctgtg tatctgctct gccactgact     1679

ggccttgact atccaacacc ctatctgaaa gaaataaaaa tcaaacttaa aaaaaaaaaa     1739

aaaaaaaaaa aa                                                         1751


<210>  34
<211>  315
<212>  PRT
<213>  Mus musculus - Tumor-associated calcium signal transducer 1

<400>  34

Met Ala Gly Pro Gln Ala Leu Ala Phe Gly Leu Leu Leu Ala Val Val 
1               5                   10                  15      


Thr Ala Thr Leu Ala Ala Ala Gln Arg Asp Cys Val Cys Asp Asn Tyr 
            20                  25                  30          


Lys Leu Ala Thr Ser Cys Ser Leu Asn Glu Tyr Gly Glu Cys Gln Cys 
        35                  40                  45              


Thr Ser Tyr Gly Thr Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ser 
    50                  55                  60                  


Lys Cys Leu Ala Met Lys Ala Glu Met Thr His Ser Lys Ser Gly Arg 
65                  70                  75                  80  


Arg Ile Lys Pro Glu Gly Ala Ile Gln Asn Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Glu Gln Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 
            100                 105                 110         


Thr Ala Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 
    130                 135                 140                 


Ile Ile Glu Leu Lys His Lys Glu Arg Glu Ser Pro Tyr Asp His Gln 
145                 150                 155                 160 


Ser Leu Gln Thr Ala Leu Gln Glu Ala Phe Thr Ser Arg Tyr Lys Leu 
                165                 170                 175     


Asn Gln Lys Phe Ile Lys Asn Ile Met Tyr Glu Asn Asn Val Ile Thr 
            180                 185                 190         


Ile Asp Leu Met Gln Asn Ser Ser Gln Lys Thr Gln Asp Asp Val Asp 
        195                 200                 205             


Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 
    210                 215                 220                 


Leu Phe His Ser Ser Lys Ser Met Asp Leu Arg Val Asn Gly Glu Pro 
225                 230                 235                 240 


Leu Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys 
                245                 250                 255     


Ala Pro Glu Phe Ser Met Gln Gly Leu Thr Ala Gly Ile Ile Ala Val 
            260                 265                 270         


Ile Val Val Val Ser Leu Ala Val Ile Ala Gly Ile Val Val Leu Val 
        275                 280                 285             


Ile Ser Thr Arg Lys Lys Ser Ala Lys Tyr Glu Lys Ala Glu Ile Lys 
    290                 295                 300                 


Glu Met Gly Glu Ile His Arg Glu Leu Asn Ala 
305                 310                 315 


<210>  35
<211>  1458
<212>  DNA
<213>  Homo sapiens - Tumor-associated calcium signal transducer 1


<220>
<221>  CDS
<222>  (183)..(1127)

<400>  35
ccttcggcga gcgagcacct tcgacgcggt ccggggaccc cctcgtcgct gtcctcccga       60

cgcggacccg cgtgccccag gcctcgcgct gcccggccgg ctcctcgtgt cccactcccg      120

gcgcacgccc tcccgcgagt cccgggcccc tcccgcgccc ctcttctcgg cgcgcgcgca      180

gc atg gcg ccc ccg cag gtc ctc gcg ttc ggg ctt ctg ctt gcc gcg         227
   Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala            
   1               5                   10                  15             

gcg acg gcg act ttt gcc gca gct cag gaa gaa tgt gtc tgt gaa aac        275
Ala Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn           
                20                  25                  30                

tac aag ctg gcc gta aac tgc ttt gtg aat aat aat cgt caa tgc cag        323
Tyr Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln           
            35                  40                  45                    

tgt act tca gtt ggt gca caa aat act gtc att tgc tca aag ctg gct        371
Cys Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala           
        50                  55                  60                        

gcc aaa tgt ttg gtg atg aag gca gaa atg aat ggc tca aaa ctt ggg        419
Ala Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly           
    65                  70                  75                            

aga aga gca aaa cct gaa ggg gcc ctc cag aac aat gat ggg ctt tat        467
Arg Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr           
80                  85                  90                  95            

gat cct gac tgc gat gag agc ggg ctc ttt aag gcc aag cag tgc aac        515
Asp Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn           
                100                 105                 110               

ggc acc tcc acg tgc tgg tgt gtg aac act gct ggg gtc aga aga aca        563
Gly Thr Ser Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr           
            115                 120                 125                   

gac aag gac act gaa ata acc tgc tct gag cga gtg aga acc tac tgg        611
Asp Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp           
        130                 135                 140                       

atc atc att gaa cta aaa cac aaa gca aga gaa aaa cct tat gat agt        659
Ile Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser           
    145                 150                 155                           

aaa agt ttg cgg act gca ctt cag aag gag atc aca acg cgt tat caa        707
Lys Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln           
160                 165                 170                 175           

ctg gat cca aaa ttt atc acg agt att ttg tat gag aat aat gtt atc        755
Leu Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile           
                180                 185                 190               

act att gat ctg gtt caa aat tct tct caa aaa act cag aat gat gtg        803
Thr Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val           
            195                 200                 205                   

gac ata gct gat gtg gct tat tat ttt gaa aaa gat gtt aaa ggt gaa        851
Asp Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu           
        210                 215                 220                       

tcc ttg ttt cat tct aag aaa atg gac ctg aca gta aat ggg gaa caa        899
Ser Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln           
    225                 230                 235                           

ctg gat ctg gat cct ggt caa act tta att tat tat gtt gat gaa aaa        947
Leu Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys           
240                 245                 250                 255           

gca cct gaa ttc tca atg cag ggt cta aaa gct ggt gtt att gct gtt        995
Ala Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val           
                260                 265                 270               

att gtg gtt gtg gtg ata gca gtt gtt gct gga att gtt gtg ctg gtt       1043
Ile Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val           
            275                 280                 285                   

att tcc aga aag aag aga atg gca aag tat gag aag gct gag ata aag       1091
Ile Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys           
        290                 295                 300                       

gag atg ggt gag atg cat agg gaa ctc aat gca taa ctatataatt            1137
Glu Met Gly Glu Met His Arg Glu Leu Asn Ala                               
    305                 310                                               

tgaagattat agaagaaggg aaatagcaaa tggacacaaa ttacaaatgt gtgtgcgtgg     1197

gacgaagaca tctttgaagg tcatgagttt gttagtttaa catcatatat ttgtaatagt     1257

gaaacctgta ctcaaaatat aagcagcttg aaactggctt taccaatctt gaaatttgac     1317

cacaagtgtc ttatatatgc agatctaatg taaaatccag aacttggact ccatcgttaa     1377

aattatttat gtgtaacatt caaatgtgtg cattaaatat gcttccacag taaaatctga     1437

aaaactgaaa aaaaaaaaaa a                                               1458


<210>  36
<211>  314
<212>  PRT
<213>  Homo sapiens - Tumor-associated calcium signal transducer 1

<400>  36

Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr 
            20                  25                  30          


Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys 
        35                  40                  45              


Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala 
    50                  55                  60                  


Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg 
65                  70                  75                  80  


Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 
            100                 105                 110         


Thr Ser Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 
    130                 135                 140                 


Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys 
145                 150                 155                 160 


Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu 
                165                 170                 175     


Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr 
            180                 185                 190         


Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp 
        195                 200                 205             


Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 
    210                 215                 220                 


Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu 
225                 230                 235                 240 


Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala 
                245                 250                 255     


Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile 
            260                 265                 270         


Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile 
        275                 280                 285             


Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 
    290                 295                 300                 


Met Gly Glu Met His Arg Glu Leu Asn Ala 
305                 310                 


<210>  37
<211>  1400
<212>  DNA
<213>  Mus musculus - RIKEN cDNA 2310005E10 gene


<220>
<221>  CDS
<222>  (103)..(1053)

<400>  37
ccacgcgtcc gcccacgcgt ccgcccacgc gtccgcccac gcgtccgcct aatttaggca       60

aaggctcccg tctgttccct ttgaaccgtt tctgcagcaa cc atg gcc gcc ttc         114
                                               Met Ala Ala Phe            
                                               1                          

gtg acg ctc ctt acc gga gcc aag atg ccc att gtg ggc ctg ggc acc        162
Val Thr Leu Leu Thr Gly Ala Lys Met Pro Ile Val Gly Leu Gly Thr           
5                   10                  15                  20            

tgg aag tct ccc cca gct aaa gtc agg gaa gct gtg aag gtg gcc att        210
Trp Lys Ser Pro Pro Ala Lys Val Arg Glu Ala Val Lys Val Ala Ile           
                25                  30                  35                

gat gct ggg tat cgc cac att gat tgt gcc tat gtc tat cag aat gag        258
Asp Ala Gly Tyr Arg His Ile Asp Cys Ala Tyr Val Tyr Gln Asn Glu           
            40                  45                  50                    

agc gag gtg gga gaa gcc atc caa gag aag atc cag gag aag gct gtg        306
Ser Glu Val Gly Glu Ala Ile Gln Glu Lys Ile Gln Glu Lys Ala Val           
        55                  60                  65                        

aag cgg gag gac ctc ttc atc gtc agc aag ctg tgg tcc acc ttc ttt        354
Lys Arg Glu Asp Leu Phe Ile Val Ser Lys Leu Trp Ser Thr Phe Phe           
    70                  75                  80                            

gag aaa agc ctg gtg aag aaa gcc ttc cag aac acc ctc tcg gat ctg        402
Glu Lys Ser Leu Val Lys Lys Ala Phe Gln Asn Thr Leu Ser Asp Leu           
85                  90                  95                  100           

aag ctt gac tac ctg gac ctg tat cta atc cac tgg cca cag gga ttt        450
Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro Gln Gly Phe           
                105                 110                 115               

cag tct gga aat gtc ttt tta ccc aca gat gat aaa ggc agt att ctc        498
Gln Ser Gly Asn Val Phe Leu Pro Thr Asp Asp Lys Gly Ser Ile Leu           
            120                 125                 130                   

agc agt aaa tat acg ttc ttg gat gct tgg gag gcc atg gag gaa ctg        546
Ser Ser Lys Tyr Thr Phe Leu Asp Ala Trp Glu Ala Met Glu Glu Leu           
        135                 140                 145                       

gtg gac cag gga ctg gtg aaa gct ctg ggt gtc tcc aac ttc aac cac        594
Val Asp Gln Gly Leu Val Lys Ala Leu Gly Val Ser Asn Phe Asn His           
    150                 155                 160                           

ttc cag att gaa agg ctc ctg aac aag cct gga ctg aaa cat aag cca        642
Phe Gln Ile Glu Arg Leu Leu Asn Lys Pro Gly Leu Lys His Lys Pro           
165                 170                 175                 180           

gtg acc aac cag gtt gag tgt cac cct tac ctc acc cag gaa aaa ctg        690
Val Thr Asn Gln Val Glu Cys His Pro Tyr Leu Thr Gln Glu Lys Leu           
                185                 190                 195               

acc cag tac tgt cac tcc aag ggc atc acc atc aca gcc tac agt ccc        738
Thr Gln Tyr Cys His Ser Lys Gly Ile Thr Ile Thr Ala Tyr Ser Pro           
            200                 205                 210                   

ctg ggc tcc cca gac agg cct agt gcc aaa cca gag gac ccc cta tta        786
Leu Gly Ser Pro Asp Arg Pro Ser Ala Lys Pro Glu Asp Pro Leu Leu           
        215                 220                 225                       

ctg gag att ccc aag atc aaa gag att gct gca aag cac aag aag act        834
Leu Glu Ile Pro Lys Ile Lys Glu Ile Ala Ala Lys His Lys Lys Thr           
    230                 235                 240                           

gca gca cag gtt ctg att cgg ttc cat ata gag agg aac gtg gtg gtg        882
Ala Ala Gln Val Leu Ile Arg Phe His Ile Glu Arg Asn Val Val Val           
245                 250                 255                 260           

atc ccc aag tct gtg aca cct tct cga ata cag gag aac att cag gtc        930
Ile Pro Lys Ser Val Thr Pro Ser Arg Ile Gln Glu Asn Ile Gln Val           
                265                 270                 275               

ttc gac ttc cag tta agt gag gag gac atg gcc gcc att ctc agc ttc        978
Phe Asp Phe Gln Leu Ser Glu Glu Asp Met Ala Ala Ile Leu Ser Phe           
            280                 285                 290                   

aac agg aac tgg agg gcc tgt ggc ctg ttt gca gca agt cat aac gag       1026
Asn Arg Asn Trp Arg Ala Cys Gly Leu Phe Ala Ala Ser His Asn Glu           
        295                 300                 305                       

gac ttc cct ttc cat gcg gaa tac tga agccgagtac cagatgcgct             1073
Asp Phe Pro Phe His Ala Glu Tyr                                           
    310                 315                                               

tgcctggagg acactcttca ctgatatgca acccgctcct actgactcct atttttgcca     1133

agcctattgg atatcatacc aaaccagcct caacagtgca attctgcatt taaattctca     1193

tgttcaacta gaagcagact gtcacaggaa gatgcatctc agcaaagggc aatgtttgtc     1253

actaatttga cctggccgga tgtttgtcag aaaccaggaa cactaataac actgaagatt     1313

aaaaagataa aataataaaa atagcaataa tcgtaaaaaa aaaaaaaaaa aaaaaaaaaa     1373

aaaaaaaaaa aaaaaaaaaa aaaaaaa                                         1400


<210>  38
<211>  316
<212>  PRT
<213>  Mus musculus - RIKEN cDNA 2310005E10 gene

<400>  38

Met Ala Ala Phe Val Thr Leu Leu Thr Gly Ala Lys Met Pro Ile Val 
1               5                   10                  15      


Gly Leu Gly Thr Trp Lys Ser Pro Pro Ala Lys Val Arg Glu Ala Val 
            20                  25                  30          


Lys Val Ala Ile Asp Ala Gly Tyr Arg His Ile Asp Cys Ala Tyr Val 
        35                  40                  45              


Tyr Gln Asn Glu Ser Glu Val Gly Glu Ala Ile Gln Glu Lys Ile Gln 
    50                  55                  60                  


Glu Lys Ala Val Lys Arg Glu Asp Leu Phe Ile Val Ser Lys Leu Trp 
65                  70                  75                  80  


Ser Thr Phe Phe Glu Lys Ser Leu Val Lys Lys Ala Phe Gln Asn Thr 
                85                  90                  95      


Leu Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp 
            100                 105                 110         


Pro Gln Gly Phe Gln Ser Gly Asn Val Phe Leu Pro Thr Asp Asp Lys 
        115                 120                 125             


Gly Ser Ile Leu Ser Ser Lys Tyr Thr Phe Leu Asp Ala Trp Glu Ala 
    130                 135                 140                 


Met Glu Glu Leu Val Asp Gln Gly Leu Val Lys Ala Leu Gly Val Ser 
145                 150                 155                 160 


Asn Phe Asn His Phe Gln Ile Glu Arg Leu Leu Asn Lys Pro Gly Leu 
                165                 170                 175     


Lys His Lys Pro Val Thr Asn Gln Val Glu Cys His Pro Tyr Leu Thr 
            180                 185                 190         


Gln Glu Lys Leu Thr Gln Tyr Cys His Ser Lys Gly Ile Thr Ile Thr 
        195                 200                 205             


Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Ser Ala Lys Pro Glu 
    210                 215                 220                 


Asp Pro Leu Leu Leu Glu Ile Pro Lys Ile Lys Glu Ile Ala Ala Lys 
225                 230                 235                 240 


His Lys Lys Thr Ala Ala Gln Val Leu Ile Arg Phe His Ile Glu Arg 
                245                 250                 255     


Asn Val Val Val Ile Pro Lys Ser Val Thr Pro Ser Arg Ile Gln Glu 
            260                 265                 270         


Asn Ile Gln Val Phe Asp Phe Gln Leu Ser Glu Glu Asp Met Ala Ala 
        275                 280                 285             


Ile Leu Ser Phe Asn Arg Asn Trp Arg Ala Cys Gly Leu Phe Ala Ala 
    290                 295                 300                 


Ser His Asn Glu Asp Phe Pro Phe His Ala Glu Tyr 
305                 310                 315     


<210>  39
<211>  1655
<212>  DNA
<213>  Mus musculus - DEAD (Asp-Glu-Ala-Asp) box polypeptide 25


<220>
<221>  CDS
<222>  (360)..(1469)

<400>  39
cggagaccgc agctatggcg tcgttacttt ggggaggcga cgccggggcg gcggagagcg       60

agcggctgaa cagccacttt tcaaatctcg tccatcccag gaagaacctt cgtggtatta      120

ggagtaccac agtcccaaac atagacggct ctcttaacac ggaagatgat gatgatgatg      180

aagacgatgt agtggatttg gcagccaatt cactcttaaa caagctaatc cgtcagtcct      240

taatagaatc cagccaccga gtggaagtct tacagaagga tcccagctct ccactctact      300

cggtgaaaac ctttgaagag ctacggctaa aagaagaatt actaaaaggg atttatgca       359

atg gga ttt aac cga cca tcc aaa atc caa gag atg gcc ctc ccc atg        407
Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu Met Ala Leu Pro Met           
1               5                   10                  15                

atg cta gca cac cct ccc cag aac ctc ata gca cag agc cag tcc ggc        455
Met Leu Ala His Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser Gly           
            20                  25                  30                    

aca gga aaa act gct gcc ttt gtc tta gca atg cta agc cga gtg aat        503
Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg Val Asn           
        35                  40                  45                        

gcc ttg gaa ctg ttt cca cag tgc ctc tgc ctg gct cct acc tat gaa        551
Ala Leu Glu Leu Phe Pro Gln Cys Leu Cys Leu Ala Pro Thr Tyr Glu           
    50                  55                  60                            

ctg gct ctg cag acc ggt cgt gtg gtt gaa agg atg ggc aag ttc tgc        599
Leu Ala Leu Gln Thr Gly Arg Val Val Glu Arg Met Gly Lys Phe Cys           
65                  70                  75                  80            

gtg gat gtt gaa gtg atg tat gcc att cga gga aac cga att cca agg        647
Val Asp Val Glu Val Met Tyr Ala Ile Arg Gly Asn Arg Ile Pro Arg           
                85                  90                  95                

ggc acc gaa gtc acc aaa cag att att att ggt act cct ggg act gtc        695
Gly Thr Glu Val Thr Lys Gln Ile Ile Ile Gly Thr Pro Gly Thr Val           
            100                 105                 110                   

cta gat tgg tgt ttc aag cga aaa ctg att gat ttg aca aag atc cgt        743
Leu Asp Trp Cys Phe Lys Arg Lys Leu Ile Asp Leu Thr Lys Ile Arg           
        115                 120                 125                       

gtg ttt gtc ctg gat gaa gca gat gtg atg att gac acc caa gga ttc        791
Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Asp Thr Gln Gly Phe           
    130                 135                 140                           

tcc gat cag agc atc cgt atc caa aga gct tta ccc tct gaa tgc cag        839
Ser Asp Gln Ser Ile Arg Ile Gln Arg Ala Leu Pro Ser Glu Cys Gln           
145                 150                 155                 160           

atg ctc ctc ttt tcg gca acc ttt gag gac tct gtg tgg cag ttt gct        887
Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp Gln Phe Ala           
                165                 170                 175               

gaa cga atc att cct gac ccc aat gtt atc aag ttg cga aaa gag gaa        935
Glu Arg Ile Ile Pro Asp Pro Asn Val Ile Lys Leu Arg Lys Glu Glu           
            180                 185                 190                   

ctg acc ctg aac aac atc cgg cag tat tac gtg ttg tgt gag aac agg        983
Leu Thr Leu Asn Asn Ile Arg Gln Tyr Tyr Val Leu Cys Glu Asn Arg           
        195                 200                 205                       

aaa ggc aaa tac caa gcc ctc tgt aac atc tac ggt ggc atc acc att       1031
Lys Gly Lys Tyr Gln Ala Leu Cys Asn Ile Tyr Gly Gly Ile Thr Ile           
    210                 215                 220                           

ggc caa gcc att atc ttc tgc cag aca cgt cga aat gcc aag tgg ctg       1079
Gly Gln Ala Ile Ile Phe Cys Gln Thr Arg Arg Asn Ala Lys Trp Leu           
225                 230                 235                 240           

act gtg gag atg atg cag gat ggc cac cag gtg tcc ctg cta agt ggg       1127
Thr Val Glu Met Met Gln Asp Gly His Gln Val Ser Leu Leu Ser Gly           
                245                 250                 255               

gaa ctc aca gtg gag cag cga gct tcc atc att cag aga ttc cga gat       1175
Glu Leu Thr Val Glu Gln Arg Ala Ser Ile Ile Gln Arg Phe Arg Asp           
            260                 265                 270                   

ggc aaa gag aag gtt ctc ata acg acc aat gtc tgt gct cga ggg att       1223
Gly Lys Glu Lys Val Leu Ile Thr Thr Asn Val Cys Ala Arg Gly Ile           
        275                 280                 285                       

gat gtg aag cag gtc acc atc gtc gtg aac ttt gac ctc cct gta aac       1271
Asp Val Lys Gln Val Thr Ile Val Val Asn Phe Asp Leu Pro Val Asn           
    290                 295                 300                           

caa tca gaa gag cca gac tat gag acc tac ctc cac cgt ata ggg cgg       1319
Gln Ser Glu Glu Pro Asp Tyr Glu Thr Tyr Leu His Arg Ile Gly Arg           
305                 310                 315                 320           

acg gga cgc ttt ggg aaa aaa ggt ctc gcc ttc aac atg att gaa gtg       1367
Thr Gly Arg Phe Gly Lys Lys Gly Leu Ala Phe Asn Met Ile Glu Val           
                325                 330                 335               

gat aag ctg ccc ctg ctt atg aaa ata caa gac ccc ttc aat agc aat       1415
Asp Lys Leu Pro Leu Leu Met Lys Ile Gln Asp Pro Phe Asn Ser Asn           
            340                 345                 350                   

att aag cag ctt gac cca gaa gac atg gat gag att gag aag atc gaa       1463
Ile Lys Gln Leu Asp Pro Glu Asp Met Asp Glu Ile Glu Lys Ile Glu           
        355                 360                 365                       

tat tga agagagagag agaagagagg ccttcgttgt ttgtgggcta gtttacgtga        1519
Tyr                                                                       
                                                                          

gaatgtttca gcagagtttg aagataattt tctatgttga gactctgtca aggtgaaact     1579

gtcacagata aaaaataaat gccatgactc tcttcaaaaa aaaaaaaaaa aaaaaaaaaa     1639

aaaaaaaaaa aaaaaa                                                     1655


<210>  40
<211>  369
<212>  PRT
<213>  Mus musculus - DEAD (Asp-Glu-Ala-Asp) box polypeptide 25

<400>  40

Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu Met Ala Leu Pro Met 
1               5                   10                  15      


Met Leu Ala His Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser Gly 
            20                  25                  30          


Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg Val Asn 
        35                  40                  45              


Ala Leu Glu Leu Phe Pro Gln Cys Leu Cys Leu Ala Pro Thr Tyr Glu 
    50                  55                  60                  


Leu Ala Leu Gln Thr Gly Arg Val Val Glu Arg Met Gly Lys Phe Cys 
65                  70                  75                  80  


Val Asp Val Glu Val Met Tyr Ala Ile Arg Gly Asn Arg Ile Pro Arg 
                85                  90                  95      


Gly Thr Glu Val Thr Lys Gln Ile Ile Ile Gly Thr Pro Gly Thr Val 
            100                 105                 110         


Leu Asp Trp Cys Phe Lys Arg Lys Leu Ile Asp Leu Thr Lys Ile Arg 
        115                 120                 125             


Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Asp Thr Gln Gly Phe 
    130                 135                 140                 


Ser Asp Gln Ser Ile Arg Ile Gln Arg Ala Leu Pro Ser Glu Cys Gln 
145                 150                 155                 160 


Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp Gln Phe Ala 
                165                 170                 175     


Glu Arg Ile Ile Pro Asp Pro Asn Val Ile Lys Leu Arg Lys Glu Glu 
            180                 185                 190         


Leu Thr Leu Asn Asn Ile Arg Gln Tyr Tyr Val Leu Cys Glu Asn Arg 
        195                 200                 205             


Lys Gly Lys Tyr Gln Ala Leu Cys Asn Ile Tyr Gly Gly Ile Thr Ile 
    210                 215                 220                 


Gly Gln Ala Ile Ile Phe Cys Gln Thr Arg Arg Asn Ala Lys Trp Leu 
225                 230                 235                 240 


Thr Val Glu Met Met Gln Asp Gly His Gln Val Ser Leu Leu Ser Gly 
                245                 250                 255     


Glu Leu Thr Val Glu Gln Arg Ala Ser Ile Ile Gln Arg Phe Arg Asp 
            260                 265                 270         


Gly Lys Glu Lys Val Leu Ile Thr Thr Asn Val Cys Ala Arg Gly Ile 
        275                 280                 285             


Asp Val Lys Gln Val Thr Ile Val Val Asn Phe Asp Leu Pro Val Asn 
    290                 295                 300                 


Gln Ser Glu Glu Pro Asp Tyr Glu Thr Tyr Leu His Arg Ile Gly Arg 
305                 310                 315                 320 


Thr Gly Arg Phe Gly Lys Lys Gly Leu Ala Phe Asn Met Ile Glu Val 
                325                 330                 335     


Asp Lys Leu Pro Leu Leu Met Lys Ile Gln Asp Pro Phe Asn Ser Asn 
            340                 345                 350         


Ile Lys Gln Leu Asp Pro Glu Asp Met Asp Glu Ile Glu Lys Ile Glu 
        355                 360                 365             


Tyr 
    


<210>  41
<211>  1799
<212>  DNA
<213>  Homo sapiens - DEAD (Asp-Glu-Ala-Asp) box polypeptide 25


<220>
<221>  CDS
<222>  (365)..(1474)

<400>  41
ggcgggagca gcaatcgcag ccatggcgtc gttactgtgg ggaggcgacg caggggcggc       60

ggagagcgag cggctgaaca gccacttttc aaacctcagc caaccccgga agaacctttg      120

gggtattaag agtactgcag tccgaaacat agatggttct attaataaca tcaatgaaga      180

tgatgaagaa gatgtagtgg atttggcagc taattcactc ttaaacaagt taatccatca      240

atccttagta gaatccagtc accgtgtgga agttttacag aaggatccca gctctccact      300

ttactcagta aagacatttg aagagctgcg gctaaaggaa gagttactaa aaggaatcta      360

tgca atg gga ttt aat agg cca tct aaa atc caa gag atg gct ctc cct       409
     Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu Met Ala Leu Pro          
     1               5                   10                  15           

atg atg ctg gca cat cca ccc cag aac ctc ata gca cag agc cag tct        457
Met Met Leu Ala His Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser           
                20                  25                  30                

gga aca gga aag aca gcg gca ttt gtg ttg gca atg tta agc aga gtt        505
Gly Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg Val           
            35                  40                  45                    

aat gcc ttg gaa ttg ttc cca cag tgc ctc tgc cta gct cct act tat        553
Asn Ala Leu Glu Leu Phe Pro Gln Cys Leu Cys Leu Ala Pro Thr Tyr           
        50                  55                  60                        

gaa ttg gct ctg caa act ggc cgt gtg gtt gag cag atg gga aaa ttc        601
Glu Leu Ala Leu Gln Thr Gly Arg Val Val Glu Gln Met Gly Lys Phe           
    65                  70                  75                            

tgt gtg gat gtt caa gtg atg tat gcc att cga ggg aat cga att ccc        649
Cys Val Asp Val Gln Val Met Tyr Ala Ile Arg Gly Asn Arg Ile Pro           
80                  85                  90                  95            

aga ggc acc gac atc act aaa cag att ata att ggc act cct ggg act        697
Arg Gly Thr Asp Ile Thr Lys Gln Ile Ile Ile Gly Thr Pro Gly Thr           
                100                 105                 110               

gtc cta gat tgg tgt ttt aaa cta aaa ttg att gat ttg act aag att        745
Val Leu Asp Trp Cys Phe Lys Leu Lys Leu Ile Asp Leu Thr Lys Ile           
            115                 120                 125                   

cgt gtg ttt gtc ctg gat gaa gca gat gtg atg att gac act caa gga        793
Arg Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Asp Thr Gln Gly           
        130                 135                 140                       

ttc tca gat cat agt att cgt att caa aga gct cta ccc tcc gaa tgc        841
Phe Ser Asp His Ser Ile Arg Ile Gln Arg Ala Leu Pro Ser Glu Cys           
    145                 150                 155                           

caa atg ctc ctc ttt tca gca acc ttt gag gac tct gtg tgg cac ttt        889
Gln Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp His Phe           
160                 165                 170                 175           

gct gag cga atc atc cct gac cct aat gtt atc aag tta cgc aaa gag        937
Ala Glu Arg Ile Ile Pro Asp Pro Asn Val Ile Lys Leu Arg Lys Glu           
                180                 185                 190               

gag ctc aca ctg aac aac atc cgg caa tat tac gtg ctg tgt gag cac        985
Glu Leu Thr Leu Asn Asn Ile Arg Gln Tyr Tyr Val Leu Cys Glu His           
            195                 200                 205                   

agg aaa gac aaa tac caa gct ctg tgc aac att tat ggc agc atc acc       1033
Arg Lys Asp Lys Tyr Gln Ala Leu Cys Asn Ile Tyr Gly Ser Ile Thr           
        210                 215                 220                       

att ggt cag gcc atc atc ttc tgc cag act cgt cga aac gct aag tgg       1081
Ile Gly Gln Ala Ile Ile Phe Cys Gln Thr Arg Arg Asn Ala Lys Trp           
    225                 230                 235                           

ttg acc gtg gag atg ata cag gat ggc cac cag gtg tct ttg tta agc       1129
Leu Thr Val Glu Met Ile Gln Asp Gly His Gln Val Ser Leu Leu Ser           
240                 245                 250                 255           

ggg gag ctg acc gtg gag cag cga gct tcc atc att cag agg ttt cgg       1177
Gly Glu Leu Thr Val Glu Gln Arg Ala Ser Ile Ile Gln Arg Phe Arg           
                260                 265                 270               

gat ggg aaa gag aag gtt ctc ata aca act aat gtt tgc gcc cga ggg       1225
Asp Gly Lys Glu Lys Val Leu Ile Thr Thr Asn Val Cys Ala Arg Gly           
            275                 280                 285                   

att gat gtg aag cag gtc aca att gtt gtg aac ttt gat ctc cct gta       1273
Ile Asp Val Lys Gln Val Thr Ile Val Val Asn Phe Asp Leu Pro Val           
        290                 295                 300                       

aaa caa gga gag gag ccg gac tat gag acc tac ctc cac cgc ata ggg       1321
Lys Gln Gly Glu Glu Pro Asp Tyr Glu Thr Tyr Leu His Arg Ile Gly           
    305                 310                 315                           

cgg acg ggg cgc ttt ggg aaa aaa ggc ctt gcc ttc aac atg att gaa       1369
Arg Thr Gly Arg Phe Gly Lys Lys Gly Leu Ala Phe Asn Met Ile Glu           
320                 325                 330                 335           

gta gat gag ctg ccc tcg ctc atg aaa atc cag gac cac ttt aac agc       1417
Val Asp Glu Leu Pro Ser Leu Met Lys Ile Gln Asp His Phe Asn Ser           
                340                 345                 350               

agt att aag caa ctc aac gct gaa gac atg gat gaa att gaa aag att       1465
Ser Ile Lys Gln Leu Asn Ala Glu Asp Met Asp Glu Ile Glu Lys Ile           
            355                 360                 365                   

gac tat tga agaaagaact ttattgtttg tgcagtatcc tagtttatgt               1514
Asp Tyr                                                                   
                                                                          

gagaatgtct cagtgggttt tgaaggtaat ttttttatgt tgaggctttt tcgacgtgaa     1574

actgtcacag atggcaaaat aaatgtcacg gtacttagtt ttaagacatg aggtcttttt     1634

gaagccaaat tgatgtgaag cttgtgatcc ttttgaataa aaaaaaggca agattaaaaa     1694

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1754

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                     1799


<210>  42
<211>  369
<212>  PRT
<213>  Homo sapiens - DEAD (Asp-Glu-Ala-Asp) box polypeptide 25

<400>  42

Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu Met Ala Leu Pro Met 
1               5                   10                  15      


Met Leu Ala His Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser Gly 
            20                  25                  30          


Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg Val Asn 
        35                  40                  45              


Ala Leu Glu Leu Phe Pro Gln Cys Leu Cys Leu Ala Pro Thr Tyr Glu 
    50                  55                  60                  


Leu Ala Leu Gln Thr Gly Arg Val Val Glu Gln Met Gly Lys Phe Cys 
65                  70                  75                  80  


Val Asp Val Gln Val Met Tyr Ala Ile Arg Gly Asn Arg Ile Pro Arg 
                85                  90                  95      


Gly Thr Asp Ile Thr Lys Gln Ile Ile Ile Gly Thr Pro Gly Thr Val 
            100                 105                 110         


Leu Asp Trp Cys Phe Lys Leu Lys Leu Ile Asp Leu Thr Lys Ile Arg 
        115                 120                 125             


Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Asp Thr Gln Gly Phe 
    130                 135                 140                 


Ser Asp His Ser Ile Arg Ile Gln Arg Ala Leu Pro Ser Glu Cys Gln 
145                 150                 155                 160 


Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp His Phe Ala 
                165                 170                 175     


Glu Arg Ile Ile Pro Asp Pro Asn Val Ile Lys Leu Arg Lys Glu Glu 
            180                 185                 190         


Leu Thr Leu Asn Asn Ile Arg Gln Tyr Tyr Val Leu Cys Glu His Arg 
        195                 200                 205             


Lys Asp Lys Tyr Gln Ala Leu Cys Asn Ile Tyr Gly Ser Ile Thr Ile 
    210                 215                 220                 


Gly Gln Ala Ile Ile Phe Cys Gln Thr Arg Arg Asn Ala Lys Trp Leu 
225                 230                 235                 240 


Thr Val Glu Met Ile Gln Asp Gly His Gln Val Ser Leu Leu Ser Gly 
                245                 250                 255     


Glu Leu Thr Val Glu Gln Arg Ala Ser Ile Ile Gln Arg Phe Arg Asp 
            260                 265                 270         


Gly Lys Glu Lys Val Leu Ile Thr Thr Asn Val Cys Ala Arg Gly Ile 
        275                 280                 285             


Asp Val Lys Gln Val Thr Ile Val Val Asn Phe Asp Leu Pro Val Lys 
    290                 295                 300                 


Gln Gly Glu Glu Pro Asp Tyr Glu Thr Tyr Leu His Arg Ile Gly Arg 
305                 310                 315                 320 


Thr Gly Arg Phe Gly Lys Lys Gly Leu Ala Phe Asn Met Ile Glu Val 
                325                 330                 335     


Asp Glu Leu Pro Ser Leu Met Lys Ile Gln Asp His Phe Asn Ser Ser 
            340                 345                 350         


Ile Lys Gln Leu Asn Ala Glu Asp Met Asp Glu Ile Glu Lys Ile Asp 
        355                 360                 365             


Tyr 
    


<210>  43
<211>  2999
<212>  DNA
<213>  Mus musculus - Neuropeptide Y receptor Y1


<220>
<221>  CDS
<222>  (249)..(1397)

<400>  43
aatctttagg gtttgagcag gagaaatacc aacagatctt ttctccctcc agtgacactc       60

gtcccgcttc aacagaggtg aacagacgca ttctttaaaa gagtattcag ttcaagggaa      120

tgaagaactg agaattatct tggtgaatgg attcaaatat atggaataag agtatgctga      180

agatttgatc cgttttgaag aactataact gtccatttat ctaatcggta acaacaaaac      240

ataaaaaa atg aac tca act ctg ttc tcc aag gtt gaa aat cac tca att       290
         Met Asn Ser Thr Leu Phe Ser Lys Val Glu Asn His Ser Ile          
         1               5                   10                           

cac tat aat gcc tca gag aat tct cca ctt ctg gct ttt gaa aat gat        338
His Tyr Asn Ala Ser Glu Asn Ser Pro Leu Leu Ala Phe Glu Asn Asp           
15                  20                  25                  30            

gac tgc cac ctg ccc ttg gct gtg ata ttc acc ttg gct ctc gct tat        386
Asp Cys His Leu Pro Leu Ala Val Ile Phe Thr Leu Ala Leu Ala Tyr           
                35                  40                  45                

ggg gcg gtg att att ctt ggc gtc tct gga aac ctg gca ttg atc ata        434
Gly Ala Val Ile Ile Leu Gly Val Ser Gly Asn Leu Ala Leu Ile Ile           
            50                  55                  60                    

atc att ctg aaa cag aag gag atg aga aat gtc acc aac att ctg atc        482
Ile Ile Leu Lys Gln Lys Glu Met Arg Asn Val Thr Asn Ile Leu Ile           
        65                  70                  75                        

gtg aac ctc tcc ttc tca gac ttg ctc gtt gcg gtc atg tgt ctc ccg        530
Val Asn Leu Ser Phe Ser Asp Leu Leu Val Ala Val Met Cys Leu Pro           
    80                  85                  90                            

ttc act ttt gta tat aca ctg atg gac cac tgg gtc ttc ggg gag acc        578
Phe Thr Phe Val Tyr Thr Leu Met Asp His Trp Val Phe Gly Glu Thr           
95                  100                 105                 110           

atg tgc aaa ctg aat ccc ttt gta cag tgt gtc tcc atc aca gta tcc        626
Met Cys Lys Leu Asn Pro Phe Val Gln Cys Val Ser Ile Thr Val Ser           
                115                 120                 125               

att ttc tcg ctg gtt ctc atc gct gtg gaa cgg cat cag cta atc atc        674
Ile Phe Ser Leu Val Leu Ile Ala Val Glu Arg His Gln Leu Ile Ile           
            130                 135                 140                   

aac cca aga ggg tgg aga cca aac aat aga cat gct tac ata ggc att        722
Asn Pro Arg Gly Trp Arg Pro Asn Asn Arg His Ala Tyr Ile Gly Ile           
        145                 150                 155                       

act gtc att tgg gtc ctt gca gtg gct tct tct ctg ccc ttt gtg atc        770
Thr Val Ile Trp Val Leu Ala Val Ala Ser Ser Leu Pro Phe Val Ile           
    160                 165                 170                           

tat caa att ctg acc gac gag ccc ttc caa aat gtg tca ctt gcg gcg        818
Tyr Gln Ile Leu Thr Asp Glu Pro Phe Gln Asn Val Ser Leu Ala Ala           
175                 180                 185                 190           

ttc aag gac aag tat gtg tgc ttt gac aaa ttc cca tct gac tct cac        866
Phe Lys Asp Lys Tyr Val Cys Phe Asp Lys Phe Pro Ser Asp Ser His           
                195                 200                 205               

agg ctg tct tac acg act ctc ctc ctg gtg ctg cag tat ttc ggc cca        914
Arg Leu Ser Tyr Thr Thr Leu Leu Leu Val Leu Gln Tyr Phe Gly Pro           
            210                 215                 220                   

ctc tgc ttt ata ttc ata tgc tac ttc aag ata tac att cgc ttg aaa        962
Leu Cys Phe Ile Phe Ile Cys Tyr Phe Lys Ile Tyr Ile Arg Leu Lys           
        225                 230                 235                       

agg aga aac aac atg atg gac aag atc cgg gac agt aag tac agg tcc       1010
Arg Arg Asn Asn Met Met Asp Lys Ile Arg Asp Ser Lys Tyr Arg Ser           
    240                 245                 250                           

agt gag acc aag cga atc aac atc atg ctg ctc tcc att gtg gtc gcc       1058
Ser Glu Thr Lys Arg Ile Asn Ile Met Leu Leu Ser Ile Val Val Ala           
255                 260                 265                 270           

ttc gcc gtc tgc tgg ctg ccc ctt acc atc ttc aac act gtg ttc gac       1106
Phe Ala Val Cys Trp Leu Pro Leu Thr Ile Phe Asn Thr Val Phe Asp           
                275                 280                 285               

tgg aac cac cag atc att gcc acc tgc aac cac aat ctg ctg ttt ctg       1154
Trp Asn His Gln Ile Ile Ala Thr Cys Asn His Asn Leu Leu Phe Leu           
            290                 295                 300                   

ctc tgt cac ctc acc gcc atg atc tcc acc tgc gtc aac ccc atc ttt       1202
Leu Cys His Leu Thr Ala Met Ile Ser Thr Cys Val Asn Pro Ile Phe           
        305                 310                 315                       

tat gga ttc ctg aac aaa aat ttc cag aga gac ttg cag ttc ttc ttc       1250
Tyr Gly Phe Leu Asn Lys Asn Phe Gln Arg Asp Leu Gln Phe Phe Phe           
    320                 325                 330                           

aac ttt tgt gac ttc cgg tct cga gac gat gac tac gag acc ata gcc       1298
Asn Phe Cys Asp Phe Arg Ser Arg Asp Asp Asp Tyr Glu Thr Ile Ala           
335                 340                 345                 350           

atg tct acc atg cat acg gat gtg tcc aag acg tct ctg aag cag gct       1346
Met Ser Thr Met His Thr Asp Val Ser Lys Thr Ser Leu Lys Gln Ala           
                355                 360                 365               

agc cca gtc gca ttt aaa aaa atc agt atg aat gac aat gaa aaa gtc       1394
Ser Pro Val Ala Phe Lys Lys Ile Ser Met Asn Asp Asn Glu Lys Val           
            370                 375                 380                   

tga agctgctcag agcatatggt cccaggccat atctgtggaa aaacaagcac            1447

agcctgccgc atgctttctt tacctatgct ctgggggaac ggaatgaggc gcgcttggaa     1507

agcccaggac atctgtgttg ggtttgactg cttttgatgg ttgccctgat tacttagaaa     1567

tctagattac tttgtaatct atctctggca acagttttga ctagatgtcc tgtgtgtgtg     1627

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tgtgtgtgcg cgcgcgcgcg     1687

cgcgcacgtg caaaagagaa agagagagag agaaggagag agacagacag actgcctgtc     1747

tgtctgtctg tctgtctttc tttatgtatg tgtttgaatt atgcatatga caaagagttt     1807

tacattgtgt ttgttggagt gaatttctct gaagtaatgt catgagctca tttcaaaagc     1867

agtcaccacc tgatattctc aagatactga attttcaaga tcagatgaga tttccaagac     1927

cccggactac cttcgttccc tgctaggcat catcttagtc tgtcacaagg gtgacagtat     1987

acaaaagtca ccttttaaaa tgtgcctgag tcaaaagagt gtctgaagtc atttggcagc     2047

atcttttcct tttcctctct atttctgtaa ggactcaatt tcttatactc ctaattgagt     2107

cttgcctaag ataaagataa gtaaagaaca ccttttcagc tgtggatatc accaggagtt     2167

aggccaccca caagaatgaa gtggcagctg ggcgtggtgg cacacacctt taatcccagc     2227

acttgggagg cagaggcagg tggatttctg agtttgaggc cagcctggtc tacaaagtga     2287

gttccagaac agccagggct atacagagaa accctgtctc gaaagacccc cccccccaaa     2347

aaaaaagaat gaagtggcaa aacaggtccc tgattttaaa atttttctga caaccaaagc     2407

attttagggt aattagttta aaatgtaaac tagtcttgct gcagataggt aaattgcatc     2467

caaaggactt gataatcgaa aggttttgca ttgttcatca gagtgctgag ctctatcaag     2527

ctttctggca caagcatgcg actcagagca tttctaactc atactgcaca gacgcgtaag     2587

atgcgttttc tacacagccg tgcctgcata gtaactagtg tttaactctc accatttatc     2647

cttcactgca gaggacacag ggacaatgtc aatgtatcta cccttcagct aacagatgtc     2707

tgtacctaaa actttcacgc agcctaactt gtataaactg tatacaagtt caagttcatc     2767

ctaacttgta taaactgtat aatgtgtgga gttttataat catatactat tatatcatag     2827

agtactgagt agccctgcca tattgatata tttactttca tgtatcttgt aatcatgatt     2887

tagactcaga aaagatactt tgaagaacaa gacagtttca atgtattgta caaaatgttg     2947

cctgtgtgtg attttagaag ggcagacact tctgaattaa aactgagctt tt             2999


<210>  44
<211>  382
<212>  PRT
<213>  Mus musculus - Neuropeptide Y receptor Y1

<400>  44

Met Asn Ser Thr Leu Phe Ser Lys Val Glu Asn His Ser Ile His Tyr 
1               5                   10                  15      


Asn Ala Ser Glu Asn Ser Pro Leu Leu Ala Phe Glu Asn Asp Asp Cys 
            20                  25                  30          


His Leu Pro Leu Ala Val Ile Phe Thr Leu Ala Leu Ala Tyr Gly Ala 
        35                  40                  45              


Val Ile Ile Leu Gly Val Ser Gly Asn Leu Ala Leu Ile Ile Ile Ile 
    50                  55                  60                  


Leu Lys Gln Lys Glu Met Arg Asn Val Thr Asn Ile Leu Ile Val Asn 
65                  70                  75                  80  


Leu Ser Phe Ser Asp Leu Leu Val Ala Val Met Cys Leu Pro Phe Thr 
                85                  90                  95      


Phe Val Tyr Thr Leu Met Asp His Trp Val Phe Gly Glu Thr Met Cys 
            100                 105                 110         


Lys Leu Asn Pro Phe Val Gln Cys Val Ser Ile Thr Val Ser Ile Phe 
        115                 120                 125             


Ser Leu Val Leu Ile Ala Val Glu Arg His Gln Leu Ile Ile Asn Pro 
    130                 135                 140                 


Arg Gly Trp Arg Pro Asn Asn Arg His Ala Tyr Ile Gly Ile Thr Val 
145                 150                 155                 160 


Ile Trp Val Leu Ala Val Ala Ser Ser Leu Pro Phe Val Ile Tyr Gln 
                165                 170                 175     


Ile Leu Thr Asp Glu Pro Phe Gln Asn Val Ser Leu Ala Ala Phe Lys 
            180                 185                 190         


Asp Lys Tyr Val Cys Phe Asp Lys Phe Pro Ser Asp Ser His Arg Leu 
        195                 200                 205             


Ser Tyr Thr Thr Leu Leu Leu Val Leu Gln Tyr Phe Gly Pro Leu Cys 
    210                 215                 220                 


Phe Ile Phe Ile Cys Tyr Phe Lys Ile Tyr Ile Arg Leu Lys Arg Arg 
225                 230                 235                 240 


Asn Asn Met Met Asp Lys Ile Arg Asp Ser Lys Tyr Arg Ser Ser Glu 
                245                 250                 255     


Thr Lys Arg Ile Asn Ile Met Leu Leu Ser Ile Val Val Ala Phe Ala 
            260                 265                 270         


Val Cys Trp Leu Pro Leu Thr Ile Phe Asn Thr Val Phe Asp Trp Asn 
        275                 280                 285             


His Gln Ile Ile Ala Thr Cys Asn His Asn Leu Leu Phe Leu Leu Cys 
    290                 295                 300                 


His Leu Thr Ala Met Ile Ser Thr Cys Val Asn Pro Ile Phe Tyr Gly 
305                 310                 315                 320 


Phe Leu Asn Lys Asn Phe Gln Arg Asp Leu Gln Phe Phe Phe Asn Phe 
                325                 330                 335     


Cys Asp Phe Arg Ser Arg Asp Asp Asp Tyr Glu Thr Ile Ala Met Ser 
            340                 345                 350         


Thr Met His Thr Asp Val Ser Lys Thr Ser Leu Lys Gln Ala Ser Pro 
        355                 360                 365             


Val Ala Phe Lys Lys Ile Ser Met Asn Asp Asn Glu Lys Val 
    370                 375                 380         


<210>  45
<211>  2775
<212>  DNA
<213>  Homo sapiens - Neuropeptide Y receptor Y1


<220>
<221>  CDS
<222>  (267)..(1421)

<400>  45
aatctttagg atctgagcag gagaaatacc agcggatctt ccccactctg ctcccttcca       60

ttcccaccct tccttcttta ataagcagga gcgaaaaaga caaattccaa agaggattgt      120

tcagttcaag ggaatgaaga attcagaata attttggtaa atggattcca atatggggaa      180

taagaataag ctgaacagtt gacctgcttt gaagaaacat actgtccatt tgtctaaaat      240

aatctataac aaccaaacca atcaaa atg aat tca aca tta ttt tcc cag gtt       293
                             Met Asn Ser Thr Leu Phe Ser Gln Val          
                             1               5                            

gaa aat cat tca gtc cac tct aat ttc tca gag aag aat gcc cag ctt        341
Glu Asn His Ser Val His Ser Asn Phe Ser Glu Lys Asn Ala Gln Leu           
10                  15                  20                  25            

ctg gct ttt gaa aat gat gat tgt cat ctg ccc ttg gcc atg ata ttt        389
Leu Ala Phe Glu Asn Asp Asp Cys His Leu Pro Leu Ala Met Ile Phe           
                30                  35                  40                

acc tta gct ctt gct tat gga gct gtg atc att ctt ggt gtc tct gga        437
Thr Leu Ala Leu Ala Tyr Gly Ala Val Ile Ile Leu Gly Val Ser Gly           
            45                  50                  55                    

aac ctg gcc ttg atc ata atc atc ttg aaa caa aag gag atg aga aat        485
Asn Leu Ala Leu Ile Ile Ile Ile Leu Lys Gln Lys Glu Met Arg Asn           
        60                  65                  70                        

gtt acc aac atc ctg att gtg aac ctt tcc ttc tca gac ttg ctt gtt        533
Val Thr Asn Ile Leu Ile Val Asn Leu Ser Phe Ser Asp Leu Leu Val           
    75                  80                  85                            

gcc atc atg tgt ctc ccc ttt aca ttt gtc tac aca tta atg gac cac        581
Ala Ile Met Cys Leu Pro Phe Thr Phe Val Tyr Thr Leu Met Asp His           
90                  95                  100                 105           

tgg gtc ttt ggt gag gcg atg tgt aag ttg aat cct ttt gtg caa tgt        629
Trp Val Phe Gly Glu Ala Met Cys Lys Leu Asn Pro Phe Val Gln Cys           
                110                 115                 120               

gtt tca atc act gtg tcc att ttc tct ctg gtt ctc att gct gtg gaa        677
Val Ser Ile Thr Val Ser Ile Phe Ser Leu Val Leu Ile Ala Val Glu           
            125                 130                 135                   

cga cat cag ctg ata atc aac cct cga ggg tgg aga cca aat aat aga        725
Arg His Gln Leu Ile Ile Asn Pro Arg Gly Trp Arg Pro Asn Asn Arg           
        140                 145                 150                       

cat gct tat gta ggt att gct gtg att tgg gtc ctt gct gtg gct tct        773
His Ala Tyr Val Gly Ile Ala Val Ile Trp Val Leu Ala Val Ala Ser           
    155                 160                 165                           

tct ttg cct ttc ctg atc tac caa gta atg act gat gag ccg ttc caa        821
Ser Leu Pro Phe Leu Ile Tyr Gln Val Met Thr Asp Glu Pro Phe Gln           
170                 175                 180                 185           

aat gta aca ctt gat gcg tac aaa gac aaa tac gtg tgc ttt gat caa        869
Asn Val Thr Leu Asp Ala Tyr Lys Asp Lys Tyr Val Cys Phe Asp Gln           
                190                 195                 200               

ttt cca tcg gac tct cat agg ttg tct tat acc act ctc ctc ttg gtg        917
Phe Pro Ser Asp Ser His Arg Leu Ser Tyr Thr Thr Leu Leu Leu Val           
            205                 210                 215                   

ctg cag tat ttt ggt cca ctt tgt ttt ata ttt att tgc tac ttc aag        965
Leu Gln Tyr Phe Gly Pro Leu Cys Phe Ile Phe Ile Cys Tyr Phe Lys           
        220                 225                 230                       

ata tat ata cgc cta aaa agg aga aac aac atg atg gac aag atg aga       1013
Ile Tyr Ile Arg Leu Lys Arg Arg Asn Asn Met Met Asp Lys Met Arg           
    235                 240                 245                           

gac aat aag tac agg tcc agt gaa acc aaa aga atc aat atc atg ctg       1061
Asp Asn Lys Tyr Arg Ser Ser Glu Thr Lys Arg Ile Asn Ile Met Leu           
250                 255                 260                 265           

ctc tcc att gtg gta gca ttt gca gtc tgc tgg ctc cct ctt acc atc       1109
Leu Ser Ile Val Val Ala Phe Ala Val Cys Trp Leu Pro Leu Thr Ile           
                270                 275                 280               

ttt aac act gtg ttt gat tgg aat cat cag atc att gct acc tgc aac       1157
Phe Asn Thr Val Phe Asp Trp Asn His Gln Ile Ile Ala Thr Cys Asn           
            285                 290                 295                   

cac aat ctg tta ttc ctg ctc tgc cac ctc aca gca atg ata tcc act       1205
His Asn Leu Leu Phe Leu Leu Cys His Leu Thr Ala Met Ile Ser Thr           
        300                 305                 310                       

tgt gtc aac ccc ata ttt tat ggg ttc ctg aac aaa aac ttc cag aga       1253
Cys Val Asn Pro Ile Phe Tyr Gly Phe Leu Asn Lys Asn Phe Gln Arg           
    315                 320                 325                           

gac ttg cag ttc ttc ttc aac ttt tgt gat ttc cgg tct cgg gat gat       1301
Asp Leu Gln Phe Phe Phe Asn Phe Cys Asp Phe Arg Ser Arg Asp Asp           
330                 335                 340                 345           

gat tat gaa aca ata gcc atg tcc acg atg cac aca gat gtt tcc aaa       1349
Asp Tyr Glu Thr Ile Ala Met Ser Thr Met His Thr Asp Val Ser Lys           
                350                 355                 360               

act tct ttg aag caa gca agc cca gtc gca ttt aaa aaa atc aac aac       1397
Thr Ser Leu Lys Gln Ala Ser Pro Val Ala Phe Lys Lys Ile Asn Asn           
            365                 370                 375                   

aat gat gat aat gaa aaa atc tga aactacttat agcctatggt cccggatgac      1451
Asn Asp Asp Asn Glu Lys Ile                                               
        380                                                               

atctgtttaa aaacaagcac aacctgcaac atactttgat tacctgttct cccaaggaat     1511

ggggttgaaa tcatttgaaa atgactaaga ttttcttgtc ttgcttttta ctgcttttgt     1571

tgtagttgtc ataattacat ttggaacaaa aggtgtgggc tttggggtct tctggaaata     1631

gttttgacca gacatctttg aagtgctttt tgtgaattta tgcatataat ataaagactt     1691

ttatactgta cttattggaa tgaaatttct ttaaagtatt actattaact gacttcagaa     1751

gtacctgcca tccaatacgg tcattagatt gggtcatctt gattagatta gattagatta     1811

gattgtcaac agattgggcc atccttactt tatgataggc atcattttag tgtgttacaa     1871

tagtaacagt atgcaaaagc agcattcagg agccgaaaga tagtctgaag tcattcagaa     1931

gtggtttgag gtttctgttt tttggtggtt tttgtttgtt tttttttttt ttcaccttaa     1991

gggaggattt aatttgctcc caactgattg tcacttaaat gaaaatttaa aaatgaataa     2051

aaagacatac ttctcagctg caaatattat ggagaattgg ggcacccaca ggaatgaaga     2111

gagaaagcag ctccctaact tcaaaaccat tttggtacct gacaacaaga gcattttaga     2171

gtaattaatt taataaagta aattagtatt gctgcaaata gttaaattat atttatttga     2231

attgatggtc aagagatttt ccattttttt tacagactgt tcagtgtttg tcaagctttc     2291

tggcataaat atgtactcaa aaggcatttc cgcttacaat ttgtagaaac acaaaatgcg     2351

ttttccatac agcagtgcct atatagtgac tgatttttaa ctttcaatgt ccatctttca     2411

aaggaagtaa caccaaggta caatgttaaa ggaatattca ctttacctag cagggaaaaa     2471

tacacaaaaa ctgcagatac ttcatatagc ccattttaac ttgtataaac tgtgtgactt     2531

gtggcgtctt ataaataatg cactgtaaag attactgaat agttgtgtca tgttaatgtg     2591

cctaatttca tgtatcttgt aatcatgatt gagcctcaga atcatttgga gaaactatat     2651

tttaaagaac aagacatact tcaatgtatt atacagataa agtattacat gtgtttgatt     2711

ttaaaagggc ggacatttta ttaaaatcaa tattgttttt gctttttcaa aaaaaaaaaa     2771

aaaa                                                                  2775


<210>  46
<211>  384
<212>  PRT
<213>  Homo sapiens - Neuropeptide Y receptor Y1

<400>  46

Met Asn Ser Thr Leu Phe Ser Gln Val Glu Asn His Ser Val His Ser 
1               5                   10                  15      


Asn Phe Ser Glu Lys Asn Ala Gln Leu Leu Ala Phe Glu Asn Asp Asp 
            20                  25                  30          


Cys His Leu Pro Leu Ala Met Ile Phe Thr Leu Ala Leu Ala Tyr Gly 
        35                  40                  45              


Ala Val Ile Ile Leu Gly Val Ser Gly Asn Leu Ala Leu Ile Ile Ile 
    50                  55                  60                  


Ile Leu Lys Gln Lys Glu Met Arg Asn Val Thr Asn Ile Leu Ile Val 
65                  70                  75                  80  


Asn Leu Ser Phe Ser Asp Leu Leu Val Ala Ile Met Cys Leu Pro Phe 
                85                  90                  95      


Thr Phe Val Tyr Thr Leu Met Asp His Trp Val Phe Gly Glu Ala Met 
            100                 105                 110         


Cys Lys Leu Asn Pro Phe Val Gln Cys Val Ser Ile Thr Val Ser Ile 
        115                 120                 125             


Phe Ser Leu Val Leu Ile Ala Val Glu Arg His Gln Leu Ile Ile Asn 
    130                 135                 140                 


Pro Arg Gly Trp Arg Pro Asn Asn Arg His Ala Tyr Val Gly Ile Ala 
145                 150                 155                 160 


Val Ile Trp Val Leu Ala Val Ala Ser Ser Leu Pro Phe Leu Ile Tyr 
                165                 170                 175     


Gln Val Met Thr Asp Glu Pro Phe Gln Asn Val Thr Leu Asp Ala Tyr 
            180                 185                 190         


Lys Asp Lys Tyr Val Cys Phe Asp Gln Phe Pro Ser Asp Ser His Arg 
        195                 200                 205             


Leu Ser Tyr Thr Thr Leu Leu Leu Val Leu Gln Tyr Phe Gly Pro Leu 
    210                 215                 220                 


Cys Phe Ile Phe Ile Cys Tyr Phe Lys Ile Tyr Ile Arg Leu Lys Arg 
225                 230                 235                 240 


Arg Asn Asn Met Met Asp Lys Met Arg Asp Asn Lys Tyr Arg Ser Ser 
                245                 250                 255     


Glu Thr Lys Arg Ile Asn Ile Met Leu Leu Ser Ile Val Val Ala Phe 
            260                 265                 270         


Ala Val Cys Trp Leu Pro Leu Thr Ile Phe Asn Thr Val Phe Asp Trp 
        275                 280                 285             


Asn His Gln Ile Ile Ala Thr Cys Asn His Asn Leu Leu Phe Leu Leu 
    290                 295                 300                 


Cys His Leu Thr Ala Met Ile Ser Thr Cys Val Asn Pro Ile Phe Tyr 
305                 310                 315                 320 


Gly Phe Leu Asn Lys Asn Phe Gln Arg Asp Leu Gln Phe Phe Phe Asn 
                325                 330                 335     


Phe Cys Asp Phe Arg Ser Arg Asp Asp Asp Tyr Glu Thr Ile Ala Met 
            340                 345                 350         


Ser Thr Met His Thr Asp Val Ser Lys Thr Ser Leu Lys Gln Ala Ser 
        355                 360                 365             


Pro Val Ala Phe Lys Lys Ile Asn Asn Asn Asp Asp Asn Glu Lys Ile 
    370                 375                 380                 


<210>  47
<211>  2025
<212>  DNA
<213>  Mus musculus - GRP1-associated scaffold protein


<220>
<221>  CDS
<222>  (96)..(1274)

<400>  47
ctacacgcgg cccgctgggc tggcgtccca aagccgtccc taacaccatc aagcagagag       60

agcgcggcct ctgaggggcg ccggacgccg gagcc atg acc ctc cgc cga ctc         113
                                       Met Thr Leu Arg Arg Leu            
                                       1               5                  

agg aag ctg cag cag aag gag gag gcg act gcc gcg ccg gac ccc gct        161
Arg Lys Leu Gln Gln Lys Glu Glu Ala Thr Ala Ala Pro Asp Pro Ala           
            10                  15                  20                    

ggc cgg gct ccc gac tcc gaa gcc gct cgc gcc gcc ccg cta ccc tcc        209
Gly Arg Ala Pro Asp Ser Glu Ala Ala Arg Ala Ala Pro Leu Pro Ser           
        25                  30                  35                        

ggc cct ccg gct gcc gcc gct ccg ccc gga gcc ccc ggg gag gag ctg        257
Gly Pro Pro Ala Ala Ala Ala Pro Pro Gly Ala Pro Gly Glu Glu Leu           
    40                  45                  50                            

tac gca gca ctg gag gac tat cac cct gcc gag ctg tac cgc gcg ctc        305
Tyr Ala Ala Leu Glu Asp Tyr His Pro Ala Glu Leu Tyr Arg Ala Leu           
55                  60                  65                  70            

gcc gtg tcc ggg ggt acc ctg cct cgc cga aag ggc tca gga ttc cgt        353
Ala Val Ser Gly Gly Thr Leu Pro Arg Arg Lys Gly Ser Gly Phe Arg           
                75                  80                  85                

tgg aag aat ttc act cag agt cct gaa cag caa cgg aag gtt cta act        401
Trp Lys Asn Phe Thr Gln Ser Pro Glu Gln Gln Arg Lys Val Leu Thr           
            90                  95                  100                   

ttg gag aaa ggg gac aac cag acc ttt ggc ttc gag atc cag aca tat        449
Leu Glu Lys Gly Asp Asn Gln Thr Phe Gly Phe Glu Ile Gln Thr Tyr           
        105                 110                 115                       

ggc ctt cac cac cga gag gag cag cgt gta gag atg gtg acc ttc gtc        497
Gly Leu His His Arg Glu Glu Gln Arg Val Glu Met Val Thr Phe Val           
    120                 125                 130                           

tgc cga gtt cat gaa tcc agc cct gcc cag ctg gct ggg ctc acg cca        545
Cys Arg Val His Glu Ser Ser Pro Ala Gln Leu Ala Gly Leu Thr Pro           
135                 140                 145                 150           

ggg gac act att gcc agc gtc aac ggt ctc aac gtg gaa ggc atc cgg        593
Gly Asp Thr Ile Ala Ser Val Asn Gly Leu Asn Val Glu Gly Ile Arg           
                155                 160                 165               

cac cgg gag att gtc gat atc atc aag gcg tct ggc aac gtt ctc agg        641
His Arg Glu Ile Val Asp Ile Ile Lys Ala Ser Gly Asn Val Leu Arg           
            170                 175                 180                   

ctg gaa act ctg tac ggg acg tcc att cgg aag gca gaa ctg gag gcg        689
Leu Glu Thr Leu Tyr Gly Thr Ser Ile Arg Lys Ala Glu Leu Glu Ala           
        185                 190                 195                       

cgc ctg cag tac ctt aag caa acc ctg tac gag aag tgg gga gaa tac        737
Arg Leu Gln Tyr Leu Lys Gln Thr Leu Tyr Glu Lys Trp Gly Glu Tyr           
    200                 205                 210                           

agg tca ctt atg gta cag gag cag cgg cta gta cat ggc ctg gtg gtg        785
Arg Ser Leu Met Val Gln Glu Gln Arg Leu Val His Gly Leu Val Val           
215                 220                 225                 230           

aaa gac cca agc atc tat gac aca ctg gag tcc gtg cgc tcc tgc ctc        833
Lys Asp Pro Ser Ile Tyr Asp Thr Leu Glu Ser Val Arg Ser Cys Leu           
                235                 240                 245               

tac ggc gca ggc ttg ctt ccc ggg tcg ctg ccc ttt ggg cct ctg ctc        881
Tyr Gly Ala Gly Leu Leu Pro Gly Ser Leu Pro Phe Gly Pro Leu Leu           
            250                 255                 260                   

gcc gcg cct ggg agt gcc cgc ggg ggt gcg cgg cgg gcc aaa ggg gac        929
Ala Ala Pro Gly Ser Ala Arg Gly Gly Ala Arg Arg Ala Lys Gly Asp           
        265                 270                 275                       

aca gac gac gcc gtg tac cac acg tgc ttc ttt ggg ggc gcc gag ccg        977
Thr Asp Asp Ala Val Tyr His Thr Cys Phe Phe Gly Gly Ala Glu Pro           
    280                 285                 290                           

cag gca ctg cca ccc ccg cca ccc ccc gcg cgc gcg tta ggc ccg agc       1025
Gln Ala Leu Pro Pro Pro Pro Pro Pro Ala Arg Ala Leu Gly Pro Ser           
295                 300                 305                 310           

tcc gcg gag acc ccc gcg tcc gtg ctg ttt ccc gca cct cgc tcc acg       1073
Ser Ala Glu Thr Pro Ala Ser Val Leu Phe Pro Ala Pro Arg Ser Thr           
                315                 320                 325               

ctc agc cgc agc gcc agt gtg cgg tgc gcg ggc ccg ggc ggc ggc ggg       1121
Leu Ser Arg Ser Ala Ser Val Arg Cys Ala Gly Pro Gly Gly Gly Gly           
            330                 335                 340                   

ggc gcg ccg ggc gca ctc tgg act gag gcc cgc gag cag gcc ctg tgt       1169
Gly Ala Pro Gly Ala Leu Trp Thr Glu Ala Arg Glu Gln Ala Leu Cys           
        345                 350                 355                       

ggc gcc ggc cta cgc aag acc aag tac cgc agc ttc cgc aga cgg ctg       1217
Gly Ala Gly Leu Arg Lys Thr Lys Tyr Arg Ser Phe Arg Arg Arg Leu           
    360                 365                 370                           

ctc aag ttc atc ccc gga ctc aac cgc tcc ctg gag gaa gag gag agc       1265
Leu Lys Phe Ile Pro Gly Leu Asn Arg Ser Leu Glu Glu Glu Glu Ser           
375                 380                 385                 390           

cag ctg tag gggcgcgggt gggcaggtgg gaagtattta tttatttatt               1314
Gln Leu                                                                   
                                                                          

catcgtaaca gcctgtgcaa aaagtagggg cggtagtgtc ggtccaagga ccccgggagc     1374

ccaaagctgc gggagagggt ccttgctagc tctggtcttt ctggtcggtt cattggcttg     1434

tctgctgaac aaaaaaaaaa gggggggggg gctagttgct ttctgccctc ccctaaacca     1494

cagcaggagc tctacagggg gagaatagac actgggaatt gggagaaatc tgggggacca     1554

aagagggctg taccaggcta aagtctgggt cagtcgtgcc ttgtgggggt cctgtcccaa     1614

gaaaccctct cctcagatat actggctccc cagcccttcc ttagccttgg ggagaggaga     1674

tccacgatgg atcattcccc accctacaga gacagacaga cagatacaca cacacacaca     1734

cacacacaca cacacacaca cacatcaatg gaccagtggg ccccaagggg gcaaggtgct     1794

ggtcccctcc ctccaacctt gacccctaag ggcttaaccc ctgtccaggg gcctataact     1854

aagtggggtc ctgccaggcc ggggtcctgg gttctgtgct ccttggggaa caagaatgag     1914

ttcattcagg tggggtgggg cagcctggac tgttccaccg ttttctgcat atgttgcttc     1974

tgaaccacaa actgtataaa attgatgggt tttttttgca aaaaaaaaaa a              2025


<210>  48
<211>  392
<212>  PRT
<213>  Mus musculus - GRP1-associated scaffold protein

<400>  48

Met Thr Leu Arg Arg Leu Arg Lys Leu Gln Gln Lys Glu Glu Ala Thr 
1               5                   10                  15      


Ala Ala Pro Asp Pro Ala Gly Arg Ala Pro Asp Ser Glu Ala Ala Arg 
            20                  25                  30          


Ala Ala Pro Leu Pro Ser Gly Pro Pro Ala Ala Ala Ala Pro Pro Gly 
        35                  40                  45              


Ala Pro Gly Glu Glu Leu Tyr Ala Ala Leu Glu Asp Tyr His Pro Ala 
    50                  55                  60                  


Glu Leu Tyr Arg Ala Leu Ala Val Ser Gly Gly Thr Leu Pro Arg Arg 
65                  70                  75                  80  


Lys Gly Ser Gly Phe Arg Trp Lys Asn Phe Thr Gln Ser Pro Glu Gln 
                85                  90                  95      


Gln Arg Lys Val Leu Thr Leu Glu Lys Gly Asp Asn Gln Thr Phe Gly 
            100                 105                 110         


Phe Glu Ile Gln Thr Tyr Gly Leu His His Arg Glu Glu Gln Arg Val 
        115                 120                 125             


Glu Met Val Thr Phe Val Cys Arg Val His Glu Ser Ser Pro Ala Gln 
    130                 135                 140                 


Leu Ala Gly Leu Thr Pro Gly Asp Thr Ile Ala Ser Val Asn Gly Leu 
145                 150                 155                 160 


Asn Val Glu Gly Ile Arg His Arg Glu Ile Val Asp Ile Ile Lys Ala 
                165                 170                 175     


Ser Gly Asn Val Leu Arg Leu Glu Thr Leu Tyr Gly Thr Ser Ile Arg 
            180                 185                 190         


Lys Ala Glu Leu Glu Ala Arg Leu Gln Tyr Leu Lys Gln Thr Leu Tyr 
        195                 200                 205             


Glu Lys Trp Gly Glu Tyr Arg Ser Leu Met Val Gln Glu Gln Arg Leu 
    210                 215                 220                 


Val His Gly Leu Val Val Lys Asp Pro Ser Ile Tyr Asp Thr Leu Glu 
225                 230                 235                 240 


Ser Val Arg Ser Cys Leu Tyr Gly Ala Gly Leu Leu Pro Gly Ser Leu 
                245                 250                 255     


Pro Phe Gly Pro Leu Leu Ala Ala Pro Gly Ser Ala Arg Gly Gly Ala 
            260                 265                 270         


Arg Arg Ala Lys Gly Asp Thr Asp Asp Ala Val Tyr His Thr Cys Phe 
        275                 280                 285             


Phe Gly Gly Ala Glu Pro Gln Ala Leu Pro Pro Pro Pro Pro Pro Ala 
    290                 295                 300                 


Arg Ala Leu Gly Pro Ser Ser Ala Glu Thr Pro Ala Ser Val Leu Phe 
305                 310                 315                 320 


Pro Ala Pro Arg Ser Thr Leu Ser Arg Ser Ala Ser Val Arg Cys Ala 
                325                 330                 335     


Gly Pro Gly Gly Gly Gly Gly Ala Pro Gly Ala Leu Trp Thr Glu Ala 
            340                 345                 350         


Arg Glu Gln Ala Leu Cys Gly Ala Gly Leu Arg Lys Thr Lys Tyr Arg 
        355                 360                 365             


Ser Phe Arg Arg Arg Leu Leu Lys Phe Ile Pro Gly Leu Asn Arg Ser 
    370                 375                 380                 


Leu Glu Glu Glu Glu Ser Gln Leu 
385                 390         


<210>  49
<211>  1950
<212>  DNA
<213>  Homo sapiens - GRP1-associated scaffold protein


<220>
<221>  CDS
<222>  (57)..(1244)

<400>  49
ccagccccgc cgaggggagc cagcgccgtc tctgaggggc gtccggcgcc ggagcc atg       59
                                                              Met         
                                                              1           

acc ctc cgc cga ctc agg aag ctg cag cag aag gag gag gcg gcg gcc        107
Thr Leu Arg Arg Leu Arg Lys Leu Gln Gln Lys Glu Glu Ala Ala Ala           
            5                   10                  15                    

acc ccg gac ccc gcc gcc cgg act ccc gac tcg gaa gtc gcg ccc gcc        155
Thr Pro Asp Pro Ala Ala Arg Thr Pro Asp Ser Glu Val Ala Pro Ala           
        20                  25                  30                        

gct ccg gtc ccg acc ccg gga ccc cct gcc gca gcc gcc acc cct ggg        203
Ala Pro Val Pro Thr Pro Gly Pro Pro Ala Ala Ala Ala Thr Pro Gly           
    35                  40                  45                            

ccc cca gcg gac gag ctg tac gcg gcg ctg gag gac tat cac cct gcc        251
Pro Pro Ala Asp Glu Leu Tyr Ala Ala Leu Glu Asp Tyr His Pro Ala           
50                  55                  60                  65            

gag ctg tac cgc gcg ctc gcc gtg tcc ggg ggc acc ctg ccc cgc cga        299
Glu Leu Tyr Arg Ala Leu Ala Val Ser Gly Gly Thr Leu Pro Arg Arg           
                70                  75                  80                

aag ggc tca gga ttc cgc tgg aag aat ctc agc cag agt cct gaa cag        347
Lys Gly Ser Gly Phe Arg Trp Lys Asn Leu Ser Gln Ser Pro Glu Gln           
            85                  90                  95                    

cag cgg aaa gtg ctg acg ttg gag aag gag gat aac cag acc ttc ggc        395
Gln Arg Lys Val Leu Thr Leu Glu Lys Glu Asp Asn Gln Thr Phe Gly           
        100                 105                 110                       

ttt gag atc cag act tat ggc ctt cac cac cgg gag gag cag cgt gtg        443
Phe Glu Ile Gln Thr Tyr Gly Leu His His Arg Glu Glu Gln Arg Val           
    115                 120                 125                           

gaa atg gtg acc ttt gtc tgc cga gtt cat gag tct agc cct gcc cag        491
Glu Met Val Thr Phe Val Cys Arg Val His Glu Ser Ser Pro Ala Gln           
130                 135                 140                 145           

ctg gct ggg ctc aca cca ggg gac acc atc gcc agc gtc aat ggc ctg        539
Leu Ala Gly Leu Thr Pro Gly Asp Thr Ile Ala Ser Val Asn Gly Leu           
                150                 155                 160               

aat gtg gaa ggc atc cgg cat cga gag att gtg gac atc att aag gcg        587
Asn Val Glu Gly Ile Arg His Arg Glu Ile Val Asp Ile Ile Lys Ala           
            165                 170                 175                   

tca ggc aat gtt ctc aga ctg gaa act cta tat ggg aca tca att cgg        635
Ser Gly Asn Val Leu Arg Leu Glu Thr Leu Tyr Gly Thr Ser Ile Arg           
        180                 185                 190                       

aag gca gaa ctg gag gct cgt ctg cag tac ctg aag caa acc ctg tat        683
Lys Ala Glu Leu Glu Ala Arg Leu Gln Tyr Leu Lys Gln Thr Leu Tyr           
    195                 200                 205                           

gag aag tgg gga gag tac agg tcc cta atg gtg cag gag cag cgg ctg        731
Glu Lys Trp Gly Glu Tyr Arg Ser Leu Met Val Gln Glu Gln Arg Leu           
210                 215                 220                 225           

gtg cat ggc ctg gtg gtg aag gac ccc agc atc tac gac acg ctg gag        779
Val His Gly Leu Val Val Lys Asp Pro Ser Ile Tyr Asp Thr Leu Glu           
                230                 235                 240               

tcg gtg cgc tcc tgc ctc tac ggc gcg ggc ctg ctc ccg ggc tcg ctg        827
Ser Val Arg Ser Cys Leu Tyr Gly Ala Gly Leu Leu Pro Gly Ser Leu           
            245                 250                 255                   

ccc ttc ggg cct ctg ctc gcc gtg ccc ggg cgt ccc cgc gga ggc gcc        875
Pro Phe Gly Pro Leu Leu Ala Val Pro Gly Arg Pro Arg Gly Gly Ala           
        260                 265                 270                       

cga cgg gcc agg ggc gac gcc gac gac gcc gtc tac cac acg tgc ttc        923
Arg Arg Ala Arg Gly Asp Ala Asp Asp Ala Val Tyr His Thr Cys Phe           
    275                 280                 285                           

ttc ggg gac tcc gag ccg ccg gcg ctg ccg ccc ccg ccg ccc ccg gcc        971
Phe Gly Asp Ser Glu Pro Pro Ala Leu Pro Pro Pro Pro Pro Pro Ala           
290                 295                 300                 305           

cgc gcc ttc ggc ccg ggc ccc gcc gag acc cct gcc gtg ggg ccg ggc       1019
Arg Ala Phe Gly Pro Gly Pro Ala Glu Thr Pro Ala Val Gly Pro Gly           
                310                 315                 320               

cct ggg ccg cgg gcc gcg ctg agc cgc agc gcc agt gtg cgg tgc gcg       1067
Pro Gly Pro Arg Ala Ala Leu Ser Arg Ser Ala Ser Val Arg Cys Ala           
            325                 330                 335                   

ggc cct ggc ggg ggc gga ggc ggg ggc gcg ccg ggc gcg ctc tgg act       1115
Gly Pro Gly Gly Gly Gly Gly Gly Gly Ala Pro Gly Ala Leu Trp Thr           
        340                 345                 350                       

gag gct cgc gag cag gcc cta tgc ggc ccc ggc ctg cgc aaa acc aag       1163
Glu Ala Arg Glu Gln Ala Leu Cys Gly Pro Gly Leu Arg Lys Thr Lys           
    355                 360                 365                           

tac cgc agc ttc cgc cgg cgg ctg ctc aag ttc atc ccc gga ctc aac       1211
Tyr Arg Ser Phe Arg Arg Arg Leu Leu Lys Phe Ile Pro Gly Leu Asn           
370                 375                 380                 385           

cgc tcc ctg gag gag gag gag agc cag ctg tag gggcgggggc gggcagggag     1264
Arg Ser Leu Glu Glu Glu Glu Ser Gln Leu                                   
                390                 395                                   

gtatttattt atttattcgc aacagccagc gctaaaagag ggggaggccg agccaagagg     1324

accccaggag cccagagcag cgggagaggg tccttcctag cctcggcccg ccgggtcggt     1384

tcctggctgg tgtctgctga gggagtgggg ggcccagccc cttctcttct cccccgccaa     1444

accacagtgg gagctggggc agggggagag ccaggcaatc gggggccaaa gatgggggtg     1504

ctcgcctaca gtctgcatct gtagtgcctt gtggggtatc caggaacacc ctcccagcag     1564

gggatgggaa ccctgtccca tgaagccctc tcctcagctt tacttgctcc cccgccctta     1624

gccttgggga gaaatggccc gtggtgggct gaccccccac cctccacaca cacagttcca     1684

tgacccagcg ggcccccagg ggcatcaggt gctggtcctc ctccctcctg gcctcgaccc     1744

ctaagggctt cgcccctccc aggggcctgt aactaagtcg ggtcctgcca ggcagggggc     1804

ctgtgttctg tgccccttgg gagacaggaa ctggcgagtt caggtggggt ggggacagca     1864

cagactgttc caccgttgtg catattgttg cttctgaacc acaaactgta taaatggatg     1924

gttttttgac aaaaaaaaaa aaaaaa                                          1950


<210>  50
<211>  395
<212>  PRT
<213>  Homo sapiens - GRP1-associated scaffold protein

<400>  50

Met Thr Leu Arg Arg Leu Arg Lys Leu Gln Gln Lys Glu Glu Ala Ala 
1               5                   10                  15      


Ala Thr Pro Asp Pro Ala Ala Arg Thr Pro Asp Ser Glu Val Ala Pro 
            20                  25                  30          


Ala Ala Pro Val Pro Thr Pro Gly Pro Pro Ala Ala Ala Ala Thr Pro 
        35                  40                  45              


Gly Pro Pro Ala Asp Glu Leu Tyr Ala Ala Leu Glu Asp Tyr His Pro 
    50                  55                  60                  


Ala Glu Leu Tyr Arg Ala Leu Ala Val Ser Gly Gly Thr Leu Pro Arg 
65                  70                  75                  80  


Arg Lys Gly Ser Gly Phe Arg Trp Lys Asn Leu Ser Gln Ser Pro Glu 
                85                  90                  95      


Gln Gln Arg Lys Val Leu Thr Leu Glu Lys Glu Asp Asn Gln Thr Phe 
            100                 105                 110         


Gly Phe Glu Ile Gln Thr Tyr Gly Leu His His Arg Glu Glu Gln Arg 
        115                 120                 125             


Val Glu Met Val Thr Phe Val Cys Arg Val His Glu Ser Ser Pro Ala 
    130                 135                 140                 


Gln Leu Ala Gly Leu Thr Pro Gly Asp Thr Ile Ala Ser Val Asn Gly 
145                 150                 155                 160 


Leu Asn Val Glu Gly Ile Arg His Arg Glu Ile Val Asp Ile Ile Lys 
                165                 170                 175     


Ala Ser Gly Asn Val Leu Arg Leu Glu Thr Leu Tyr Gly Thr Ser Ile 
            180                 185                 190         


Arg Lys Ala Glu Leu Glu Ala Arg Leu Gln Tyr Leu Lys Gln Thr Leu 
        195                 200                 205             


Tyr Glu Lys Trp Gly Glu Tyr Arg Ser Leu Met Val Gln Glu Gln Arg 
    210                 215                 220                 


Leu Val His Gly Leu Val Val Lys Asp Pro Ser Ile Tyr Asp Thr Leu 
225                 230                 235                 240 


Glu Ser Val Arg Ser Cys Leu Tyr Gly Ala Gly Leu Leu Pro Gly Ser 
                245                 250                 255     


Leu Pro Phe Gly Pro Leu Leu Ala Val Pro Gly Arg Pro Arg Gly Gly 
            260                 265                 270         


Ala Arg Arg Ala Arg Gly Asp Ala Asp Asp Ala Val Tyr His Thr Cys 
        275                 280                 285             


Phe Phe Gly Asp Ser Glu Pro Pro Ala Leu Pro Pro Pro Pro Pro Pro 
    290                 295                 300                 


Ala Arg Ala Phe Gly Pro Gly Pro Ala Glu Thr Pro Ala Val Gly Pro 
305                 310                 315                 320 


Gly Pro Gly Pro Arg Ala Ala Leu Ser Arg Ser Ala Ser Val Arg Cys 
                325                 330                 335     


Ala Gly Pro Gly Gly Gly Gly Gly Gly Gly Ala Pro Gly Ala Leu Trp 
            340                 345                 350         


Thr Glu Ala Arg Glu Gln Ala Leu Cys Gly Pro Gly Leu Arg Lys Thr 
        355                 360                 365             


Lys Tyr Arg Ser Phe Arg Arg Arg Leu Leu Lys Phe Ile Pro Gly Leu 
    370                 375                 380                 


Asn Arg Ser Leu Glu Glu Glu Glu Ser Gln Leu 
385                 390                 395 


<210>  51
<211>  2474
<212>  DNA
<213>  Mus musculus - Nuclear receptor subfamily 4, group A, member 1


<220>
<221>  CDS
<222>  (109)..(1914)

<400>  51
gcgaaagttg ggggagtgtg ctagaaggac tgcggagcgg agcgcacgcg ggaccaggct       60

gcgactgggt cgctggtccc ggccacaggg agtgggagcc ggctggag atg ccc tgt       117
                                                     Met Pro Cys          
                                                     1                    

att caa gct caa tat gga aca cca gca acg agc cca gga ccg cgt gac        165
Ile Gln Ala Gln Tyr Gly Thr Pro Ala Thr Ser Pro Gly Pro Arg Asp           
    5                   10                  15                            

cac ctg acc ggt gat ccc ctg gcc ctt gag ttc ggc aag cct acc atg        213
His Leu Thr Gly Asp Pro Leu Ala Leu Glu Phe Gly Lys Pro Thr Met           
20                  25                  30                  35            

gac ctg gcc agc ccc gag aca gca cct gcc gca cct gct aca ctg ccc        261
Asp Leu Ala Ser Pro Glu Thr Ala Pro Ala Ala Pro Ala Thr Leu Pro           
                40                  45                  50                

agc ttc agc acc ttc atg gac ggg tac acc gga gag ttt gac acc ttc        309
Ser Phe Ser Thr Phe Met Asp Gly Tyr Thr Gly Glu Phe Asp Thr Phe           
            55                  60                  65                    

ctc tac cag ctg ccg ggg acg acc cag ccg tgc tcc tca gct tgt tcc        357
Leu Tyr Gln Leu Pro Gly Thr Thr Gln Pro Cys Ser Ser Ala Cys Ser           
        70                  75                  80                        

tct gcc tcc tcc acg tct tct tcc tca tcc tcg gcc acc tcc ccc gct        405
Ser Ala Ser Ser Thr Ser Ser Ser Ser Ser Ser Ala Thr Ser Pro Ala           
    85                  90                  95                            

tcg gcg tcc ttc aag ttt gag gac ttc cag gtg tac ggc tgc tac ccg        453
Ser Ala Ser Phe Lys Phe Glu Asp Phe Gln Val Tyr Gly Cys Tyr Pro           
100                 105                 110                 115           

ggc acc ctg agc ggc cca tta gat gag acc cta tcc tcc agc ggc tct        501
Gly Thr Leu Ser Gly Pro Leu Asp Glu Thr Leu Ser Ser Ser Gly Ser           
                120                 125                 130               

gag tac tat ggc agt ccc tgc tca gcc ccc tcg cca tct aca ccc aac        549
Glu Tyr Tyr Gly Ser Pro Cys Ser Ala Pro Ser Pro Ser Thr Pro Asn           
            135                 140                 145                   

ttc cag ccg tcc cag ctt tct ccc tgg gac ggc tca ttt ggc cac ttc        597
Phe Gln Pro Ser Gln Leu Ser Pro Trp Asp Gly Ser Phe Gly His Phe           
        150                 155                 160                       

tcc ccg agc cag act tat gaa ggc ctc tgg gca tgg aca gag cag ttg        645
Ser Pro Ser Gln Thr Tyr Glu Gly Leu Trp Ala Trp Thr Glu Gln Leu           
    165                 170                 175                           

cct aag gct tct tca ggg cct ccg cca cct cca acc ttc ttc tcc ttc        693
Pro Lys Ala Ser Ser Gly Pro Pro Pro Pro Pro Thr Phe Phe Ser Phe           
180                 185                 190                 195           

agt cct ccc act ggc ccc agc ccc agc ctg gcc cag agt tct ctg aaa        741
Ser Pro Pro Thr Gly Pro Ser Pro Ser Leu Ala Gln Ser Ser Leu Lys           
                200                 205                 210               

ttg ttc cca cca cca gcc acc cac cag ctt ggg gag ggg gag agc tat        789
Leu Phe Pro Pro Pro Ala Thr His Gln Leu Gly Glu Gly Glu Ser Tyr           
            215                 220                 225                   

tcc atg cca gca gct ttc ccc ggc ttg gca ccc acc tct ccg aac cgt        837
Ser Met Pro Ala Ala Phe Pro Gly Leu Ala Pro Thr Ser Pro Asn Arg           
        230                 235                 240                       

gac act tcc ggc att ctg gac gca ccc gtg acc tcc acc aag tcc cgg        885
Asp Thr Ser Gly Ile Leu Asp Ala Pro Val Thr Ser Thr Lys Ser Arg           
    245                 250                 255                           

agc ggg gct tca ggt ggc agc gag ggc cgc tgt gca gtc tgt ggt gac        933
Ser Gly Ala Ser Gly Gly Ser Glu Gly Arg Cys Ala Val Cys Gly Asp           
260                 265                 270                 275           

aat gct tcg tgt cag cac tat ggg gtc cgc acc tgt gag ggc tgc aag        981
Asn Ala Ser Cys Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys           
                280                 285                 290               

ggc ttc ttc aag cgc aca gta cag aaa agc gcc aag tac atc tgc ctg       1029
Gly Phe Phe Lys Arg Thr Val Gln Lys Ser Ala Lys Tyr Ile Cys Leu           
            295                 300                 305                   

gca aac aag gat tgc cct gtg gac aag agg cgg cgg aac cgc tgc cag       1077
Ala Asn Lys Asp Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln           
        310                 315                 320                       

ttc tgc cgc ttc cag aag tgc ctg gct gtg ggc atg gtg aag gaa gtt       1125
Phe Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val           
    325                 330                 335                           

gta cgg aca gac agc cta aaa ggg cgg cgg ggc cgg cta cct tca aaa       1173
Val Arg Thr Asp Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys           
340                 345                 350                 355           

ccc aag cag cct cca gat gcc tcc cct acc aat ctt ctc act tcc ctc       1221
Pro Lys Gln Pro Pro Asp Ala Ser Pro Thr Asn Leu Leu Thr Ser Leu           
                360                 365                 370               

atc cgg gca cac ttg gac tcc ggg cct agc act gcc aaa ttg gac tat       1269
Ile Arg Ala His Leu Asp Ser Gly Pro Ser Thr Ala Lys Leu Asp Tyr           
            375                 380                 385                   

tcc aag ttc cag gaa ctg gtg ctg ccc cgc ttc ggg aag gaa gat gcc       1317
Ser Lys Phe Gln Glu Leu Val Leu Pro Arg Phe Gly Lys Glu Asp Ala           
        390                 395                 400                       

ggt gac gtg caa caa ttt tat gac ttg ctc tct ggt tcc ctg gac gtt       1365
Gly Asp Val Gln Gln Phe Tyr Asp Leu Leu Ser Gly Ser Leu Asp Val           
    405                 410                 415                           

atc cga aag tgg gca gaa aaa atc cct ggc ttc att gag ctt tgc cca       1413
Ile Arg Lys Trp Ala Glu Lys Ile Pro Gly Phe Ile Glu Leu Cys Pro           
420                 425                 430                 435           

gga gac caa gac ctg ttg cta gag tct gcc ttc ctg gaa ctc ttc atc       1461
Gly Asp Gln Asp Leu Leu Leu Glu Ser Ala Phe Leu Glu Leu Phe Ile           
                440                 445                 450               

ctc cgc ctg gca tac cga tct aaa ccc ggt gag ggg aag ctc atc ttc       1509
Leu Arg Leu Ala Tyr Arg Ser Lys Pro Gly Glu Gly Lys Leu Ile Phe           
            455                 460                 465                   

tgc tca ggc ctg gta cta cac cag ctg cag tgt gcc cgt ggc ttt ggt       1557
Cys Ser Gly Leu Val Leu His Gln Leu Gln Cys Ala Arg Gly Phe Gly           
        470                 475                 480                       

gat tgg att gac aac atc ctg gcc ttc tca cgg tcc ctg cac agc ttg       1605
Asp Trp Ile Asp Asn Ile Leu Ala Phe Ser Arg Ser Leu His Ser Leu           
    485                 490                 495                           

ggt gtt gat gtt ccc gcc ttt gcc tgc ctg tcc gct ctg gtc ctc atc       1653
Gly Val Asp Val Pro Ala Phe Ala Cys Leu Ser Ala Leu Val Leu Ile           
500                 505                 510                 515           

act gat cga cac ggg ctc cag gac cct cgt cgg gtg gaa gag ctg cag       1701
Thr Asp Arg His Gly Leu Gln Asp Pro Arg Arg Val Glu Glu Leu Gln           
                520                 525                 530               

aat cgc att gct agc tgt ctg aag gag cac atg gct acc gtg gca gga       1749
Asn Arg Ile Ala Ser Cys Leu Lys Glu His Met Ala Thr Val Ala Gly           
            535                 540                 545                   

gac cca cag ccg gcc agc tgc ctg tca cgt ctg ctg ggc aaa ctg cct       1797
Asp Pro Gln Pro Ala Ser Cys Leu Ser Arg Leu Leu Gly Lys Leu Pro           
        550                 555                 560                       

gag ctt cgg acc ctg tgc act caa ggc ctg cag cgc atc ttt tgc ctc       1845
Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Cys Leu           
    565                 570                 575                           

aag ttg gag gac ttg gta ccc cct cca cct att gtg gac aag atc ttt       1893
Lys Leu Glu Asp Leu Val Pro Pro Pro Pro Ile Val Asp Lys Ile Phe           
580                 585                 590                 595           

atg gac aca ttg tct ttc tga cccctgccct gaacatgtgt gcgcacacgt          1944
Met Asp Thr Leu Ser Phe                                                   
                600                                                       

gcgtgctctt ctgtcaccca tgtgccttta agcctatagc ccacggaccc ccagaccacc     2004

ctacccccag cctggttttg agctaagact gacgtacctc ctcactccag aagatggaca     2064

gagaactcaa gacctggggg agggtgtgta ttcacggggg tgaccccact atttgtctta     2124

tccctccagc tcagtcctgg ccttcgtgtg tttttgtaag ataaaccatt tttaacacat     2184

accactctgt tgtaaataag ctgacgctac tgtaaataca gaaaggaaga ggttgagatg     2244

ggggttggga ggaaggggtg gggctcccac cagctgggcg agcctccaac tcgagatctc     2304

ttccgctctc cttccatgtg tacataactg tcactcaaga aggtgattga cagattctga     2364

tttatatttg tgtattttcc tggatttata ggatgtgact tttctgatta atatatttaa     2424

tatattgaat aaaaaataga catgtagttg aaaaaaaaaa aaaaaaaaaa                2474


<210>  52
<211>  601
<212>  PRT
<213>  Mus musculus - Nuclear receptor subfamily 4, group A, member 1

<400>  52

Met Pro Cys Ile Gln Ala Gln Tyr Gly Thr Pro Ala Thr Ser Pro Gly 
1               5                   10                  15      


Pro Arg Asp His Leu Thr Gly Asp Pro Leu Ala Leu Glu Phe Gly Lys 
            20                  25                  30          


Pro Thr Met Asp Leu Ala Ser Pro Glu Thr Ala Pro Ala Ala Pro Ala 
        35                  40                  45              


Thr Leu Pro Ser Phe Ser Thr Phe Met Asp Gly Tyr Thr Gly Glu Phe 
    50                  55                  60                  


Asp Thr Phe Leu Tyr Gln Leu Pro Gly Thr Thr Gln Pro Cys Ser Ser 
65                  70                  75                  80  


Ala Cys Ser Ser Ala Ser Ser Thr Ser Ser Ser Ser Ser Ser Ala Thr 
                85                  90                  95      


Ser Pro Ala Ser Ala Ser Phe Lys Phe Glu Asp Phe Gln Val Tyr Gly 
            100                 105                 110         


Cys Tyr Pro Gly Thr Leu Ser Gly Pro Leu Asp Glu Thr Leu Ser Ser 
        115                 120                 125             


Ser Gly Ser Glu Tyr Tyr Gly Ser Pro Cys Ser Ala Pro Ser Pro Ser 
    130                 135                 140                 


Thr Pro Asn Phe Gln Pro Ser Gln Leu Ser Pro Trp Asp Gly Ser Phe 
145                 150                 155                 160 


Gly His Phe Ser Pro Ser Gln Thr Tyr Glu Gly Leu Trp Ala Trp Thr 
                165                 170                 175     


Glu Gln Leu Pro Lys Ala Ser Ser Gly Pro Pro Pro Pro Pro Thr Phe 
            180                 185                 190         


Phe Ser Phe Ser Pro Pro Thr Gly Pro Ser Pro Ser Leu Ala Gln Ser 
        195                 200                 205             


Ser Leu Lys Leu Phe Pro Pro Pro Ala Thr His Gln Leu Gly Glu Gly 
    210                 215                 220                 


Glu Ser Tyr Ser Met Pro Ala Ala Phe Pro Gly Leu Ala Pro Thr Ser 
225                 230                 235                 240 


Pro Asn Arg Asp Thr Ser Gly Ile Leu Asp Ala Pro Val Thr Ser Thr 
                245                 250                 255     


Lys Ser Arg Ser Gly Ala Ser Gly Gly Ser Glu Gly Arg Cys Ala Val 
            260                 265                 270         


Cys Gly Asp Asn Ala Ser Cys Gln His Tyr Gly Val Arg Thr Cys Glu 
        275                 280                 285             


Gly Cys Lys Gly Phe Phe Lys Arg Thr Val Gln Lys Ser Ala Lys Tyr 
    290                 295                 300                 


Ile Cys Leu Ala Asn Lys Asp Cys Pro Val Asp Lys Arg Arg Arg Asn 
305                 310                 315                 320 


Arg Cys Gln Phe Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Val 
                325                 330                 335     


Lys Glu Val Val Arg Thr Asp Ser Leu Lys Gly Arg Arg Gly Arg Leu 
            340                 345                 350         


Pro Ser Lys Pro Lys Gln Pro Pro Asp Ala Ser Pro Thr Asn Leu Leu 
        355                 360                 365             


Thr Ser Leu Ile Arg Ala His Leu Asp Ser Gly Pro Ser Thr Ala Lys 
    370                 375                 380                 


Leu Asp Tyr Ser Lys Phe Gln Glu Leu Val Leu Pro Arg Phe Gly Lys 
385                 390                 395                 400 


Glu Asp Ala Gly Asp Val Gln Gln Phe Tyr Asp Leu Leu Ser Gly Ser 
                405                 410                 415     


Leu Asp Val Ile Arg Lys Trp Ala Glu Lys Ile Pro Gly Phe Ile Glu 
            420                 425                 430         


Leu Cys Pro Gly Asp Gln Asp Leu Leu Leu Glu Ser Ala Phe Leu Glu 
        435                 440                 445             


Leu Phe Ile Leu Arg Leu Ala Tyr Arg Ser Lys Pro Gly Glu Gly Lys 
    450                 455                 460                 


Leu Ile Phe Cys Ser Gly Leu Val Leu His Gln Leu Gln Cys Ala Arg 
465                 470                 475                 480 


Gly Phe Gly Asp Trp Ile Asp Asn Ile Leu Ala Phe Ser Arg Ser Leu 
                485                 490                 495     


His Ser Leu Gly Val Asp Val Pro Ala Phe Ala Cys Leu Ser Ala Leu 
            500                 505                 510         


Val Leu Ile Thr Asp Arg His Gly Leu Gln Asp Pro Arg Arg Val Glu 
        515                 520                 525             


Glu Leu Gln Asn Arg Ile Ala Ser Cys Leu Lys Glu His Met Ala Thr 
    530                 535                 540                 


Val Ala Gly Asp Pro Gln Pro Ala Ser Cys Leu Ser Arg Leu Leu Gly 
545                 550                 555                 560 


Lys Leu Pro Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile 
                565                 570                 575     


Phe Cys Leu Lys Leu Glu Asp Leu Val Pro Pro Pro Pro Ile Val Asp 
            580                 585                 590         


Lys Ile Phe Met Asp Thr Leu Ser Phe 
        595                 600     


<210>  53
<211>  2649
<212>  DNA
<213>  Homo sapiens - Nuclear receptor subfamily 4, group A, member 1


<220>
<221>  CDS
<222>  (265)..(2061)

<400>  53
ggctacgaaa cttgggggag tgcacagaag aacttcggga gcgcacgcgg gaccagggac       60

caggctgaga ctcggggcgc cagtccgggc aggggcagcg ggagccggcc gggtagggtg      120

cagcctgagg cttgttcagc agaacaggtg caagccacat tgttgccaag acctgcctga      180

agccggattc tccccactgc ctccttcaac cccgcctctt cctcctcctg tgggactgct      240

cccccctcct gtgaggctag atag atg ccc tgt atc caa gcc caa tat ggg         291
                           Met Pro Cys Ile Gln Ala Gln Tyr Gly            
                           1               5                              

aca cca gca ccg agt ccg gga ccc cgt gac cac ctg gca agc gac ccc        339
Thr Pro Ala Pro Ser Pro Gly Pro Arg Asp His Leu Ala Ser Asp Pro           
10                  15                  20                  25            

ctg acc cct gag ttc atc aag ccc acc atg gac ctg gcc agc ccc gag        387
Leu Thr Pro Glu Phe Ile Lys Pro Thr Met Asp Leu Ala Ser Pro Glu           
                30                  35                  40                

gca gcc ccc gct gcc ccc act gcc ctg ccc agc ttc agc acc ttc atg        435
Ala Ala Pro Ala Ala Pro Thr Ala Leu Pro Ser Phe Ser Thr Phe Met           
            45                  50                  55                    

gac ggc tac aca gga gag ttt gac acc ttc ctc tac cag ctg cca gga        483
Asp Gly Tyr Thr Gly Glu Phe Asp Thr Phe Leu Tyr Gln Leu Pro Gly           
        60                  65                  70                        

aca gtc cag cca tgc tcc tca gcc tcc tcc tcg gcc tcc tcc aca tcc        531
Thr Val Gln Pro Cys Ser Ser Ala Ser Ser Ser Ala Ser Ser Thr Ser           
    75                  80                  85                            

tcg tcc tca gcc acc tcc cct gcc tct gcc tcc ttc aag ttc gag gac        579
Ser Ser Ser Ala Thr Ser Pro Ala Ser Ala Ser Phe Lys Phe Glu Asp           
90                  95                  100                 105           

ttc cag gtg tac ggc tgc tac ccc ggc ccc ctg agc ggc cca gtg gat        627
Phe Gln Val Tyr Gly Cys Tyr Pro Gly Pro Leu Ser Gly Pro Val Asp           
                110                 115                 120               

gag gcc ctg tcc tcc agt ggc tct gac tac tat ggc agc ccc tgc tcg        675
Glu Ala Leu Ser Ser Ser Gly Ser Asp Tyr Tyr Gly Ser Pro Cys Ser           
            125                 130                 135                   

gcc ccg tcg ccc tcc acg ccc agc ttc cag ccg ccc cag ctc tct ccc        723
Ala Pro Ser Pro Ser Thr Pro Ser Phe Gln Pro Pro Gln Leu Ser Pro           
        140                 145                 150                       

tgg gat ggc tcc ttc ggc cac ttc tcg ccc agc cag act tac gaa ggc        771
Trp Asp Gly Ser Phe Gly His Phe Ser Pro Ser Gln Thr Tyr Glu Gly           
    155                 160                 165                           

ctg cgg gca tgg aca gag cag ctg ccc aaa gcc tct ggg ccc cca cag        819
Leu Arg Ala Trp Thr Glu Gln Leu Pro Lys Ala Ser Gly Pro Pro Gln           
170                 175                 180                 185           

cct cca gcc ttc ttt tcc ttc agt cct ccc acc ggc ccc agc ccc agc        867
Pro Pro Ala Phe Phe Ser Phe Ser Pro Pro Thr Gly Pro Ser Pro Ser           
                190                 195                 200               

ctg gcc cag agc ccc ctg aag ttg ttc ccc tca cag gcc acc cac cag        915
Leu Ala Gln Ser Pro Leu Lys Leu Phe Pro Ser Gln Ala Thr His Gln           
            205                 210                 215                   

ctg ggg gag gga gag agc tat tcc atg cct acg gcc ttc cca ggt ttg        963
Leu Gly Glu Gly Glu Ser Tyr Ser Met Pro Thr Ala Phe Pro Gly Leu           
        220                 225                 230                       

gca ccc act tct cca cac ctt gag ggc tcg ggg ata ctg gat aca ccc       1011
Ala Pro Thr Ser Pro His Leu Glu Gly Ser Gly Ile Leu Asp Thr Pro           
    235                 240                 245                           

gtg acc tca acc aag gcc cgg agc ggg gcc cca ggt gga agt gaa ggc       1059
Val Thr Ser Thr Lys Ala Arg Ser Gly Ala Pro Gly Gly Ser Glu Gly           
250                 255                 260                 265           

cgc tgt gct gtg tgt ggg gac aac gct tca tgc cag cat tat ggt gtc       1107
Arg Cys Ala Val Cys Gly Asp Asn Ala Ser Cys Gln His Tyr Gly Val           
                270                 275                 280               

cgc aca tgt gag ggc tgc aag ggc ttc ttc aag cgc aca gtg cag aaa       1155
Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys Arg Thr Val Gln Lys           
            285                 290                 295                   

aac gcc aag tac atc tgc ctg gct aac aag gac tgc cct gtg gac aag       1203
Asn Ala Lys Tyr Ile Cys Leu Ala Asn Lys Asp Cys Pro Val Asp Lys           
        300                 305                 310                       

agg cgg cga aac cgc tgc cag ttc tgc cgc ttc cag aag tgc ctg gcg       1251
Arg Arg Arg Asn Arg Cys Gln Phe Cys Arg Phe Gln Lys Cys Leu Ala           
    315                 320                 325                           

gtg ggc atg gtg aag gaa gtt gtc cga aca gac agc ctg aag ggg cgg       1299
Val Gly Met Val Lys Glu Val Val Arg Thr Asp Ser Leu Lys Gly Arg           
330                 335                 340                 345           

cgg ggc cgg cta cct tca aaa ccc aag cag ccc cca gat gcc tcc cct       1347
Arg Gly Arg Leu Pro Ser Lys Pro Lys Gln Pro Pro Asp Ala Ser Pro           
                350                 355                 360               

gcc aat ctc ctc act tcc ctg gtc cgt gca cac ctg gac tca ggg ccc       1395
Ala Asn Leu Leu Thr Ser Leu Val Arg Ala His Leu Asp Ser Gly Pro           
            365                 370                 375                   

agc act gcc aaa ctg gac tac tcc aag ttc cag gag ctg gtg ctg ccc       1443
Ser Thr Ala Lys Leu Asp Tyr Ser Lys Phe Gln Glu Leu Val Leu Pro           
        380                 385                 390                       

cac ttt ggg aag gaa gat gct ggg gat gta cag cag ttc tac gac ctg       1491
His Phe Gly Lys Glu Asp Ala Gly Asp Val Gln Gln Phe Tyr Asp Leu           
    395                 400                 405                           

ctc tcc ggt tct ctg gag gtc atc cgc aag tgg gcg gag aag atc cct       1539
Leu Ser Gly Ser Leu Glu Val Ile Arg Lys Trp Ala Glu Lys Ile Pro           
410                 415                 420                 425           

ggc ttt gct gag ctg tca ccg gct gac cag gac ctg ttg ctg gag tcg       1587
Gly Phe Ala Glu Leu Ser Pro Ala Asp Gln Asp Leu Leu Leu Glu Ser           
                430                 435                 440               

gcc ttc ctg gag ctc ttc atc ctc cgc ctg gcg tac agg tct aag cca       1635
Ala Phe Leu Glu Leu Phe Ile Leu Arg Leu Ala Tyr Arg Ser Lys Pro           
            445                 450                 455                   

ggc gag ggc aag ctc atc ttc tgc tca ggc ctg gtg cta cac cgg ctg       1683
Gly Glu Gly Lys Leu Ile Phe Cys Ser Gly Leu Val Leu His Arg Leu           
        460                 465                 470                       

cag tgt gcc cgt ggc ttc ggg gac tgg att gac agt atc ctg gcc ttc       1731
Gln Cys Ala Arg Gly Phe Gly Asp Trp Ile Asp Ser Ile Leu Ala Phe           
    475                 480                 485                           

tca agg tcc ctg cac agc ttg ctt gtc gat gtc cct gcc ttc gcc tgc       1779
Ser Arg Ser Leu His Ser Leu Leu Val Asp Val Pro Ala Phe Ala Cys           
490                 495                 500                 505           

ctc tct gcc ctt gtc ctc atc acc gac cgg cat ggg ctg cag gag ccg       1827
Leu Ser Ala Leu Val Leu Ile Thr Asp Arg His Gly Leu Gln Glu Pro           
                510                 515                 520               

cgg cgg gtg gag gag ctg cag aac cgc atc gcc agc tgc ctg aag gag       1875
Arg Arg Val Glu Glu Leu Gln Asn Arg Ile Ala Ser Cys Leu Lys Glu           
            525                 530                 535                   

cac gtg gca gct gtg gcg ggc gag ccc cag cca gcc agc tgc ctg tca       1923
His Val Ala Ala Val Ala Gly Glu Pro Gln Pro Ala Ser Cys Leu Ser           
        540                 545                 550                       

cgt ctg ttg ggc aaa ctg ccc gag ctg cgg acc ctg tgc acc cag ggc       1971
Arg Leu Leu Gly Lys Leu Pro Glu Leu Arg Thr Leu Cys Thr Gln Gly           
    555                 560                 565                           

ctg cag cgc atc ttc tac ctc aag ctg gag gac ttg gtg ccc cct cca       2019
Leu Gln Arg Ile Phe Tyr Leu Lys Leu Glu Asp Leu Val Pro Pro Pro           
570                 575                 580                 585           

ccc atc att gac aag atc ttc atg gac acg ctg ccc ttc tga               2061
Pro Ile Ile Asp Lys Ile Phe Met Asp Thr Leu Pro Phe                       
                590                 595                                   

cccctgcctg ggaacacgtg tgcacatgcg cactctcata tgccacccca tgtgccttta     2121

gtccacggac ccccagagca cccccaagcc tgggcttgag ctgcagaatg actccacctt     2181

ctcacctgct ccaggaggtt tgcagggagc tcaagccctt ggggaggggg atgccttcat     2241

gggggtgacc ccacgatttg tcttatcccc cccagcctgg ccccggcctt tatgtttttt     2301

gtaagataaa ccgtttttaa cacatagcgc cgtgctgtaa ataagcccag tgctgctgta     2361

aatacaggaa gaaagagctt gaggtgggag cggggctggg aggaagggat gggccccgcc     2421

ttcctgggca gcctttccag cctcctgctg gctctctctt cctaccctcc ttccacatgt     2481

acataaactg tcactctagg aagaagacaa atgacagatt ctgacattta tatttgtgta     2541

ttttcctgga tttatagtat gtgacttttc tgattaatat atttaatata ttgaataaaa     2601

aatagacatg tagttggaaa aaaaaaaaaa tataaaaaaa aaaaaaaa                  2649


<210>  54
<211>  598
<212>  PRT
<213>  Homo sapiens - Nuclear receptor subfamily 4, group A, member 1

<400>  54

Met Pro Cys Ile Gln Ala Gln Tyr Gly Thr Pro Ala Pro Ser Pro Gly 
1               5                   10                  15      


Pro Arg Asp His Leu Ala Ser Asp Pro Leu Thr Pro Glu Phe Ile Lys 
            20                  25                  30          


Pro Thr Met Asp Leu Ala Ser Pro Glu Ala Ala Pro Ala Ala Pro Thr 
        35                  40                  45              


Ala Leu Pro Ser Phe Ser Thr Phe Met Asp Gly Tyr Thr Gly Glu Phe 
    50                  55                  60                  


Asp Thr Phe Leu Tyr Gln Leu Pro Gly Thr Val Gln Pro Cys Ser Ser 
65                  70                  75                  80  


Ala Ser Ser Ser Ala Ser Ser Thr Ser Ser Ser Ser Ala Thr Ser Pro 
                85                  90                  95      


Ala Ser Ala Ser Phe Lys Phe Glu Asp Phe Gln Val Tyr Gly Cys Tyr 
            100                 105                 110         


Pro Gly Pro Leu Ser Gly Pro Val Asp Glu Ala Leu Ser Ser Ser Gly 
        115                 120                 125             


Ser Asp Tyr Tyr Gly Ser Pro Cys Ser Ala Pro Ser Pro Ser Thr Pro 
    130                 135                 140                 


Ser Phe Gln Pro Pro Gln Leu Ser Pro Trp Asp Gly Ser Phe Gly His 
145                 150                 155                 160 


Phe Ser Pro Ser Gln Thr Tyr Glu Gly Leu Arg Ala Trp Thr Glu Gln 
                165                 170                 175     


Leu Pro Lys Ala Ser Gly Pro Pro Gln Pro Pro Ala Phe Phe Ser Phe 
            180                 185                 190         


Ser Pro Pro Thr Gly Pro Ser Pro Ser Leu Ala Gln Ser Pro Leu Lys 
        195                 200                 205             


Leu Phe Pro Ser Gln Ala Thr His Gln Leu Gly Glu Gly Glu Ser Tyr 
    210                 215                 220                 


Ser Met Pro Thr Ala Phe Pro Gly Leu Ala Pro Thr Ser Pro His Leu 
225                 230                 235                 240 


Glu Gly Ser Gly Ile Leu Asp Thr Pro Val Thr Ser Thr Lys Ala Arg 
                245                 250                 255     


Ser Gly Ala Pro Gly Gly Ser Glu Gly Arg Cys Ala Val Cys Gly Asp 
            260                 265                 270         


Asn Ala Ser Cys Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys 
        275                 280                 285             


Gly Phe Phe Lys Arg Thr Val Gln Lys Asn Ala Lys Tyr Ile Cys Leu 
    290                 295                 300                 


Ala Asn Lys Asp Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln 
305                 310                 315                 320 


Phe Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val 
                325                 330                 335     


Val Arg Thr Asp Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys 
            340                 345                 350         


Pro Lys Gln Pro Pro Asp Ala Ser Pro Ala Asn Leu Leu Thr Ser Leu 
        355                 360                 365             


Val Arg Ala His Leu Asp Ser Gly Pro Ser Thr Ala Lys Leu Asp Tyr 
    370                 375                 380                 


Ser Lys Phe Gln Glu Leu Val Leu Pro His Phe Gly Lys Glu Asp Ala 
385                 390                 395                 400 


Gly Asp Val Gln Gln Phe Tyr Asp Leu Leu Ser Gly Ser Leu Glu Val 
                405                 410                 415     


Ile Arg Lys Trp Ala Glu Lys Ile Pro Gly Phe Ala Glu Leu Ser Pro 
            420                 425                 430         


Ala Asp Gln Asp Leu Leu Leu Glu Ser Ala Phe Leu Glu Leu Phe Ile 
        435                 440                 445             


Leu Arg Leu Ala Tyr Arg Ser Lys Pro Gly Glu Gly Lys Leu Ile Phe 
    450                 455                 460                 


Cys Ser Gly Leu Val Leu His Arg Leu Gln Cys Ala Arg Gly Phe Gly 
465                 470                 475                 480 


Asp Trp Ile Asp Ser Ile Leu Ala Phe Ser Arg Ser Leu His Ser Leu 
                485                 490                 495     


Leu Val Asp Val Pro Ala Phe Ala Cys Leu Ser Ala Leu Val Leu Ile 
            500                 505                 510         


Thr Asp Arg His Gly Leu Gln Glu Pro Arg Arg Val Glu Glu Leu Gln 
        515                 520                 525             


Asn Arg Ile Ala Ser Cys Leu Lys Glu His Val Ala Ala Val Ala Gly 
    530                 535                 540                 


Glu Pro Gln Pro Ala Ser Cys Leu Ser Arg Leu Leu Gly Lys Leu Pro 
545                 550                 555                 560 


Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                565                 570                 575     


Lys Leu Glu Asp Leu Val Pro Pro Pro Pro Ile Ile Asp Lys Ile Phe 
            580                 585                 590         


Met Asp Thr Leu Pro Phe 
        595             


<210>  55
<211>  2526
<212>  DNA
<213>  Mus musculus - SRY-box containing gene 5


<220>
<221>  CDS
<222>  (85)..(2232)

<400>  55
ggtttggacc gacttgacag gttcagttgg agccagccga tcataggtgg ccgctgtgac       60

aaagggaaac tgtgcttttc cagc atg ctt act gac cct gat tta cct cag         111
                           Met Leu Thr Asp Pro Asp Leu Pro Gln            
                           1               5                              

gag ttt gaa agg atg tct tcc aag cga cca gcc tct ccg tat ggg gag        159
Glu Phe Glu Arg Met Ser Ser Lys Arg Pro Ala Ser Pro Tyr Gly Glu           
10                  15                  20                  25            

aca gat gga gag gta gcc atg gtg aca agc aga cag aaa gtg gaa gag        207
Thr Asp Gly Glu Val Ala Met Val Thr Ser Arg Gln Lys Val Glu Glu           
                30                  35                  40                

gag gag agt gag agg ctc cca gcc ttt cac ctt ccc tta cat gtg agt        255
Glu Glu Ser Glu Arg Leu Pro Ala Phe His Leu Pro Leu His Val Ser           
            45                  50                  55                    

ttt ccc aac aag cct cac tct gag gaa ttt cag cca gtt tct ctg ctg        303
Phe Pro Asn Lys Pro His Ser Glu Glu Phe Gln Pro Val Ser Leu Leu           
        60                  65                  70                        

acg caa gag act tgt ggt cct agg acc ccc act gtg cag cac aac aca        351
Thr Gln Glu Thr Cys Gly Pro Arg Thr Pro Thr Val Gln His Asn Thr           
    75                  80                  85                            

atg gaa gtc gat ggc aat aaa gtt atg tct tca tta gct cca tac aac        399
Met Glu Val Asp Gly Asn Lys Val Met Ser Ser Leu Ala Pro Tyr Asn           
90                  95                  100                 105           

tca tct acc tca cct cag aag gcg gaa gaa ggt ggg cga cag agt ggc        447
Ser Ser Thr Ser Pro Gln Lys Ala Glu Glu Gly Gly Arg Gln Ser Gly           
                110                 115                 120               

gag tcc gtg tcg agc gca gcc ctg ggg act ccc gag cgg cgc aag ggc        495
Glu Ser Val Ser Ser Ala Ala Leu Gly Thr Pro Glu Arg Arg Lys Gly           
            125                 130                 135                   

agc tta gcg gat gtg gtg gac acc ctg aag cag agg aag atg gaa gag        543
Ser Leu Ala Asp Val Val Asp Thr Leu Lys Gln Arg Lys Met Glu Glu           
        140                 145                 150                       

ctg atc aag aat gag cca gaa gac act ccc agt att gaa aag cta ctc        591
Leu Ile Lys Asn Glu Pro Glu Asp Thr Pro Ser Ile Glu Lys Leu Leu           
    155                 160                 165                           

tcc aag gac tgg aaa gac aag ctc ctg gca atg gga tca ggg aac ttt        639
Ser Lys Asp Trp Lys Asp Lys Leu Leu Ala Met Gly Ser Gly Asn Phe           
170                 175                 180                 185           

gga gaa ata aaa ggg act cct gag agc ctc gct gag aag gag cgg cag        687
Gly Glu Ile Lys Gly Thr Pro Glu Ser Leu Ala Glu Lys Glu Arg Gln           
                190                 195                 200               

ctc atg ggt atg atc aat cag ctg acc agt cta cgg gag caa ctc ctg        735
Leu Met Gly Met Ile Asn Gln Leu Thr Ser Leu Arg Glu Gln Leu Leu           
            205                 210                 215                   

gct gcc cac gat gag cag aag aag ttg gct gca tct cag ata gag aaa        783
Ala Ala His Asp Glu Gln Lys Lys Leu Ala Ala Ser Gln Ile Glu Lys           
        220                 225                 230                       

cag cgt cag cag atg gag ctg gcc aag cag caa cag gag cag atc gcg        831
Gln Arg Gln Gln Met Glu Leu Ala Lys Gln Gln Gln Glu Gln Ile Ala           
    235                 240                 245                           

agg caa cag cag cag ctt ctg cag caa caa cac aaa atc aac ttg ctt        879
Arg Gln Gln Gln Gln Leu Leu Gln Gln Gln His Lys Ile Asn Leu Leu           
250                 255                 260                 265           

cag caa cag atc cag cag gtt caa ggt cag ctg ccg cca ttg atg att        927
Gln Gln Gln Ile Gln Gln Val Gln Gly Gln Leu Pro Pro Leu Met Ile           
                270                 275                 280               

ccc gtg ttc cct cct gac cag cgg acc ctc gca gca gct gcc cag caa        975
Pro Val Phe Pro Pro Asp Gln Arg Thr Leu Ala Ala Ala Ala Gln Gln           
            285                 290                 295                   

gga ttc ctc ctt cct cct ggt ttc agc tac aag gct ggg tgc agt gac       1023
Gly Phe Leu Leu Pro Pro Gly Phe Ser Tyr Lys Ala Gly Cys Ser Asp           
        300                 305                 310                       

cct tac cct gtt cag ctg atc cca acc act atg gca gct gct gct gca       1071
Pro Tyr Pro Val Gln Leu Ile Pro Thr Thr Met Ala Ala Ala Ala Ala           
    315                 320                 325                           

gca aca cca ggc tta ggc cca ctc cag ctg cag gat gaa gtg gcc cag       1119
Ala Thr Pro Gly Leu Gly Pro Leu Gln Leu Gln Asp Glu Val Ala Gln           
330                 335                 340                 345           

cca ctg aac cta tca gct aag ccc aag acc tct gat ggc aaa tca cct       1167
Pro Leu Asn Leu Ser Ala Lys Pro Lys Thr Ser Asp Gly Lys Ser Pro           
                350                 355                 360               

gca tca ccc acc tct cct cac atg cca gct ctg aga ata aac agt ggg       1215
Ala Ser Pro Thr Ser Pro His Met Pro Ala Leu Arg Ile Asn Ser Gly           
            365                 370                 375                   

gct ggc ccc ctc aaa gcc tct gtc ccg gca gca tta gct agt cct tct       1263
Ala Gly Pro Leu Lys Ala Ser Val Pro Ala Ala Leu Ala Ser Pro Ser           
        380                 385                 390                       

gca aga gtt agc aca ata ggc tat tta aat gac cac gat gct gtc acc       1311
Ala Arg Val Ser Thr Ile Gly Tyr Leu Asn Asp His Asp Ala Val Thr           
    395                 400                 405                           

aag gca atc caa gaa gct cgc cag atg aaa gag caa ctc agg cga gag       1359
Lys Ala Ile Gln Glu Ala Arg Gln Met Lys Glu Gln Leu Arg Arg Glu           
410                 415                 420                 425           

cag caa gcg ttg gac ggg aag gtg gcc gtg gtg aac agc ata ggt ctc       1407
Gln Gln Ala Leu Asp Gly Lys Val Ala Val Val Asn Ser Ile Gly Leu           
                430                 435                 440               

agc aac tgc cgg aca gaa aag gaa aaa aca aca ctg gag agc ctg act       1455
Ser Asn Cys Arg Thr Glu Lys Glu Lys Thr Thr Leu Glu Ser Leu Thr           
            445                 450                 455                   

cag cag ttg gca gtt aaa cag aat gaa gaa ggg aaa ttt agc cat gga       1503
Gln Gln Leu Ala Val Lys Gln Asn Glu Glu Gly Lys Phe Ser His Gly           
        460                 465                 470                       

atg atg gat ttc aat atg agt gga gat tct gac gga agc gct gga gtc       1551
Met Met Asp Phe Asn Met Ser Gly Asp Ser Asp Gly Ser Ala Gly Val           
    475                 480                 485                           

tca gag tca aga att tac agg gaa tcc agg gga cgt ggt agc aac gag       1599
Ser Glu Ser Arg Ile Tyr Arg Glu Ser Arg Gly Arg Gly Ser Asn Glu           
490                 495                 500                 505           

ccc cac ata aag cgt cca atg aat gcc ttc atg gtg tgg gcg aaa gat       1647
Pro His Ile Lys Arg Pro Met Asn Ala Phe Met Val Trp Ala Lys Asp           
                510                 515                 520               

gaa cgg agg aaa atc ctt cag gcc ttt ccc gac atg cac aat tcc aac       1695
Glu Arg Arg Lys Ile Leu Gln Ala Phe Pro Asp Met His Asn Ser Asn           
            525                 530                 535                   

atc agc aag ata ctg gga tct cgc tgg aaa gct atg acc aac cta gag       1743
Ile Ser Lys Ile Leu Gly Ser Arg Trp Lys Ala Met Thr Asn Leu Glu           
        540                 545                 550                       

aaa cag cca tac tat gag gag cag gcc cgc ctc agc aaa cag cac ctg       1791
Lys Gln Pro Tyr Tyr Glu Glu Gln Ala Arg Leu Ser Lys Gln His Leu           
    555                 560                 565                           

gag aag tac ccg gac tac aag tac aag cct agg cca aag cgc acc tgt       1839
Glu Lys Tyr Pro Asp Tyr Lys Tyr Lys Pro Arg Pro Lys Arg Thr Cys           
570                 575                 580                 585           

ctg gtg gac ggc aag aaa ctg cgt atc ggg gag tac aag gcc atc atg       1887
Leu Val Asp Gly Lys Lys Leu Arg Ile Gly Glu Tyr Lys Ala Ile Met           
                590                 595                 600               

cgg aac cgg agg cag gaa atg cga cag tac ttc aac gtt ggg caa caa       1935
Arg Asn Arg Arg Gln Glu Met Arg Gln Tyr Phe Asn Val Gly Gln Gln           
            605                 610                 615                   

gca cag atc ccc atc gcg acg gcc gga gtt gta tac ccc agc gcc atc       1983
Ala Gln Ile Pro Ile Ala Thr Ala Gly Val Val Tyr Pro Ser Ala Ile           
        620                 625                 630                       

gcc atg gca gga atg ccg tcc cct cac ctg ccc tcc gag cac tcg agc       2031
Ala Met Ala Gly Met Pro Ser Pro His Leu Pro Ser Glu His Ser Ser           
    635                 640                 645                           

gtg tcc agc agc ccg gag ccc ggg atg ccc gtg atc cag agc act tac       2079
Val Ser Ser Ser Pro Glu Pro Gly Met Pro Val Ile Gln Ser Thr Tyr           
650                 655                 660                 665           

ggc gcc aag gga gag gag ccc cac atc aag gaa gag atc cag gct gag       2127
Gly Ala Lys Gly Glu Glu Pro His Ile Lys Glu Glu Ile Gln Ala Glu           
                670                 675                 680               

gac atc aac gga gag att tac gag gag tac gat gag gag gag gag gac       2175
Asp Ile Asn Gly Glu Ile Tyr Glu Glu Tyr Asp Glu Glu Glu Glu Asp           
            685                 690                 695                   

ccg gat gtg gat tat ggg agt gac agc gaa aac cac att gcg gga caa       2223
Pro Asp Val Asp Tyr Gly Ser Asp Ser Glu Asn His Ile Ala Gly Gln           
        700                 705                 710                       

gcc aac tga taagggccaa cagactgtgg tgagccgagg acttgaagaa               2272
Ala Asn                                                                   
    715                                                                   

gccctgtccg gttcatcctt cccagtggcc aagcacatta actctctcat acactgactg     2332

ttattttaac tgttagtctt atatagttgg gacatcagct gacaaataga cctcagcctc     2392

aaaaggctcg gaaagaaaag aaagaaagaa agaaagaaaa aaaattacaa gcaaaaacgt     2452

catcaagaag aagagatcga aataagctat gggttaaaca gtgccagtaa ctcagctgct     2512

acaccccagc actg                                                       2526


<210>  56
<211>  715
<212>  PRT
<213>  Mus musculus - SRY-box containing gene 5

<400>  56

Met Leu Thr Asp Pro Asp Leu Pro Gln Glu Phe Glu Arg Met Ser Ser 
1               5                   10                  15      


Lys Arg Pro Ala Ser Pro Tyr Gly Glu Thr Asp Gly Glu Val Ala Met 
            20                  25                  30          


Val Thr Ser Arg Gln Lys Val Glu Glu Glu Glu Ser Glu Arg Leu Pro 
        35                  40                  45              


Ala Phe His Leu Pro Leu His Val Ser Phe Pro Asn Lys Pro His Ser 
    50                  55                  60                  


Glu Glu Phe Gln Pro Val Ser Leu Leu Thr Gln Glu Thr Cys Gly Pro 
65                  70                  75                  80  


Arg Thr Pro Thr Val Gln His Asn Thr Met Glu Val Asp Gly Asn Lys 
                85                  90                  95      


Val Met Ser Ser Leu Ala Pro Tyr Asn Ser Ser Thr Ser Pro Gln Lys 
            100                 105                 110         


Ala Glu Glu Gly Gly Arg Gln Ser Gly Glu Ser Val Ser Ser Ala Ala 
        115                 120                 125             


Leu Gly Thr Pro Glu Arg Arg Lys Gly Ser Leu Ala Asp Val Val Asp 
    130                 135                 140                 


Thr Leu Lys Gln Arg Lys Met Glu Glu Leu Ile Lys Asn Glu Pro Glu 
145                 150                 155                 160 


Asp Thr Pro Ser Ile Glu Lys Leu Leu Ser Lys Asp Trp Lys Asp Lys 
                165                 170                 175     


Leu Leu Ala Met Gly Ser Gly Asn Phe Gly Glu Ile Lys Gly Thr Pro 
            180                 185                 190         


Glu Ser Leu Ala Glu Lys Glu Arg Gln Leu Met Gly Met Ile Asn Gln 
        195                 200                 205             


Leu Thr Ser Leu Arg Glu Gln Leu Leu Ala Ala His Asp Glu Gln Lys 
    210                 215                 220                 


Lys Leu Ala Ala Ser Gln Ile Glu Lys Gln Arg Gln Gln Met Glu Leu 
225                 230                 235                 240 


Ala Lys Gln Gln Gln Glu Gln Ile Ala Arg Gln Gln Gln Gln Leu Leu 
                245                 250                 255     


Gln Gln Gln His Lys Ile Asn Leu Leu Gln Gln Gln Ile Gln Gln Val 
            260                 265                 270         


Gln Gly Gln Leu Pro Pro Leu Met Ile Pro Val Phe Pro Pro Asp Gln 
        275                 280                 285             


Arg Thr Leu Ala Ala Ala Ala Gln Gln Gly Phe Leu Leu Pro Pro Gly 
    290                 295                 300                 


Phe Ser Tyr Lys Ala Gly Cys Ser Asp Pro Tyr Pro Val Gln Leu Ile 
305                 310                 315                 320 


Pro Thr Thr Met Ala Ala Ala Ala Ala Ala Thr Pro Gly Leu Gly Pro 
                325                 330                 335     


Leu Gln Leu Gln Asp Glu Val Ala Gln Pro Leu Asn Leu Ser Ala Lys 
            340                 345                 350         


Pro Lys Thr Ser Asp Gly Lys Ser Pro Ala Ser Pro Thr Ser Pro His 
        355                 360                 365             


Met Pro Ala Leu Arg Ile Asn Ser Gly Ala Gly Pro Leu Lys Ala Ser 
    370                 375                 380                 


Val Pro Ala Ala Leu Ala Ser Pro Ser Ala Arg Val Ser Thr Ile Gly 
385                 390                 395                 400 


Tyr Leu Asn Asp His Asp Ala Val Thr Lys Ala Ile Gln Glu Ala Arg 
                405                 410                 415     


Gln Met Lys Glu Gln Leu Arg Arg Glu Gln Gln Ala Leu Asp Gly Lys 
            420                 425                 430         


Val Ala Val Val Asn Ser Ile Gly Leu Ser Asn Cys Arg Thr Glu Lys 
        435                 440                 445             


Glu Lys Thr Thr Leu Glu Ser Leu Thr Gln Gln Leu Ala Val Lys Gln 
    450                 455                 460                 


Asn Glu Glu Gly Lys Phe Ser His Gly Met Met Asp Phe Asn Met Ser 
465                 470                 475                 480 


Gly Asp Ser Asp Gly Ser Ala Gly Val Ser Glu Ser Arg Ile Tyr Arg 
                485                 490                 495     


Glu Ser Arg Gly Arg Gly Ser Asn Glu Pro His Ile Lys Arg Pro Met 
            500                 505                 510         


Asn Ala Phe Met Val Trp Ala Lys Asp Glu Arg Arg Lys Ile Leu Gln 
        515                 520                 525             


Ala Phe Pro Asp Met His Asn Ser Asn Ile Ser Lys Ile Leu Gly Ser 
    530                 535                 540                 


Arg Trp Lys Ala Met Thr Asn Leu Glu Lys Gln Pro Tyr Tyr Glu Glu 
545                 550                 555                 560 


Gln Ala Arg Leu Ser Lys Gln His Leu Glu Lys Tyr Pro Asp Tyr Lys 
                565                 570                 575     


Tyr Lys Pro Arg Pro Lys Arg Thr Cys Leu Val Asp Gly Lys Lys Leu 
            580                 585                 590         


Arg Ile Gly Glu Tyr Lys Ala Ile Met Arg Asn Arg Arg Gln Glu Met 
        595                 600                 605             


Arg Gln Tyr Phe Asn Val Gly Gln Gln Ala Gln Ile Pro Ile Ala Thr 
    610                 615                 620                 


Ala Gly Val Val Tyr Pro Ser Ala Ile Ala Met Ala Gly Met Pro Ser 
625                 630                 635                 640 


Pro His Leu Pro Ser Glu His Ser Ser Val Ser Ser Ser Pro Glu Pro 
                645                 650                 655     


Gly Met Pro Val Ile Gln Ser Thr Tyr Gly Ala Lys Gly Glu Glu Pro 
            660                 665                 670         


His Ile Lys Glu Glu Ile Gln Ala Glu Asp Ile Asn Gly Glu Ile Tyr 
        675                 680                 685             


Glu Glu Tyr Asp Glu Glu Glu Glu Asp Pro Asp Val Asp Tyr Gly Ser 
    690                 695                 700                 


Asp Ser Glu Asn His Ile Ala Gly Gln Ala Asn 
705                 710                 715 


<210>  57
<211>  2814
<212>  DNA
<213>  Homo sapiens - SRY-box 5


<220>
<221>  CDS
<222>  (451)..(2379)

<400>  57
gagagtgaaa aaggcgagcc accaaaaccc atctccagtc tcctcccggg ggcccccagc       60

ccgcctctgt gccactttgc atcccacgcc ggaggaggca ttaacgagac cgggtaaggc      120

tttttaaacg gtccaaggtg tagagccata cttcaggagg atcctcagaa gttttggaca      180

agcctcccca aatgtggcag gtgctgtgct ggccattggt gacccaaaga tgatgaaaaa      240

tatgttcctg cccacaagga gttagcgacc tactgggctt tcctcttgct gatgacatga      300

ttcctgtttg aatctgttga caagattctg aaagctgaac agagaattct ggcactgcac      360

tgggtaggaa aaagcatttc aagaaataga taatatcaag gacatcagga caccgggagt      420

gggagagatt ggactgggag actcagcagg atg tct tcc aag cga cca gcc tct       474
                                 Met Ser Ser Lys Arg Pro Ala Ser          
                                 1               5                        

ccg tat ggg gaa gca gat gga gag gta gcc atg gtg aca agc aga cag        522
Pro Tyr Gly Glu Ala Asp Gly Glu Val Ala Met Val Thr Ser Arg Gln           
    10                  15                  20                            

aaa gtg gaa gaa gag gag agt gac ggg ctc cca gcc ttt cac ctt ccc        570
Lys Val Glu Glu Glu Glu Ser Asp Gly Leu Pro Ala Phe His Leu Pro           
25                  30                  35                  40            

ttg cat gtg agt ttt ccc aac aag cct cac tct gag gaa ttt cag cca        618
Leu His Val Ser Phe Pro Asn Lys Pro His Ser Glu Glu Phe Gln Pro           
                45                  50                  55                

gtt tct ctg ctg acg caa gag act tgt ggc cat agg act ccc act tct        666
Val Ser Leu Leu Thr Gln Glu Thr Cys Gly His Arg Thr Pro Thr Ser           
            60                  65                  70                    

cag cac aat aca atg gaa gtt gat ggc aat aaa gtt atg tct tca ttt        714
Gln His Asn Thr Met Glu Val Asp Gly Asn Lys Val Met Ser Ser Phe           
        75                  80                  85                        

gcc cca cac aac tca tct acc tca cct cag aag gca gaa gaa ggt ggg        762
Ala Pro His Asn Ser Ser Thr Ser Pro Gln Lys Ala Glu Glu Gly Gly           
    90                  95                  100                           

cga cag agt ggc gag tcc ttg tct agt aca gcc ctg gga act cct gaa        810
Arg Gln Ser Gly Glu Ser Leu Ser Ser Thr Ala Leu Gly Thr Pro Glu           
105                 110                 115                 120           

cgg cgc aag ggc agt tta gct gat gtt gtt gac acc ttg aag cag agg        858
Arg Arg Lys Gly Ser Leu Ala Asp Val Val Asp Thr Leu Lys Gln Arg           
                125                 130                 135               

aaa atg gaa gag ctc atc aaa aac gag ccg gaa gaa acc ccc agt att        906
Lys Met Glu Glu Leu Ile Lys Asn Glu Pro Glu Glu Thr Pro Ser Ile           
            140                 145                 150                   

gaa aaa cta ctc tca aag gac tgg aaa gac aag ctt ctt gca atg gga        954
Glu Lys Leu Leu Ser Lys Asp Trp Lys Asp Lys Leu Leu Ala Met Gly           
        155                 160                 165                       

tcg ggg aac ttt ggc gaa ata aaa ggg act ccc gag agc tta gct gag       1002
Ser Gly Asn Phe Gly Glu Ile Lys Gly Thr Pro Glu Ser Leu Ala Glu           
    170                 175                 180                           

aaa gaa agg caa ctc atg ggt atg atc aac cag ctg acc agc ctc cga       1050
Lys Glu Arg Gln Leu Met Gly Met Ile Asn Gln Leu Thr Ser Leu Arg           
185                 190                 195                 200           

gag cag ctg ttg gct gcc cac gat gag cag aag aaa cta gct gcc tct       1098
Glu Gln Leu Leu Ala Ala His Asp Glu Gln Lys Lys Leu Ala Ala Ser           
                205                 210                 215               

cag att gag aaa cag cgt cag caa atg gag ctg gcc aag cag caa caa       1146
Gln Ile Glu Lys Gln Arg Gln Gln Met Glu Leu Ala Lys Gln Gln Gln           
            220                 225                 230                   

gaa caa att gca aga cag cag cag cag ctt cta cag caa caa cac aaa       1194
Glu Gln Ile Ala Arg Gln Gln Gln Gln Leu Leu Gln Gln Gln His Lys           
        235                 240                 245                       

atc aat ttg ctc cag caa cag atc cag gtt caa ggt cag ctg ccg cca       1242
Ile Asn Leu Leu Gln Gln Gln Ile Gln Val Gln Gly Gln Leu Pro Pro           
    250                 255                 260                           

tta atg att ccc gta ttc cct cct gat caa cgg aca ctg gct gca gct       1290
Leu Met Ile Pro Val Phe Pro Pro Asp Gln Arg Thr Leu Ala Ala Ala           
265                 270                 275                 280           

gcc cag caa gga ttc ctc ctc cct cca ggc ttc agc tat aag gct gga       1338
Ala Gln Gln Gly Phe Leu Leu Pro Pro Gly Phe Ser Tyr Lys Ala Gly           
                285                 290                 295               

tgt agt gac cct tac cct gtt cag ctg atc cca act acc atg gca gct       1386
Cys Ser Asp Pro Tyr Pro Val Gln Leu Ile Pro Thr Thr Met Ala Ala           
            300                 305                 310                   

gct gcc gca gca aca cca ggc tta ggc cca ctc caa ctg cag cag tta       1434
Ala Ala Ala Ala Thr Pro Gly Leu Gly Pro Leu Gln Leu Gln Gln Leu           
        315                 320                 325                       

tat gct gcc cag cta gct gca atg cag gta tct cca gga ggg aag ctg       1482
Tyr Ala Ala Gln Leu Ala Ala Met Gln Val Ser Pro Gly Gly Lys Leu           
    330                 335                 340                           

cca ggc ata ccc caa ggc aac ctt ggt gct gct gta tct cct acc agc       1530
Pro Gly Ile Pro Gln Gly Asn Leu Gly Ala Ala Val Ser Pro Thr Ser           
345                 350                 355                 360           

att cac aca gac aag agc aca aac agc cca cca ccc aaa agc aag gaa       1578
Ile His Thr Asp Lys Ser Thr Asn Ser Pro Pro Pro Lys Ser Lys Glu           
                365                 370                 375               

aaa aca aca ctg gag agt ctg act cag caa ctg gca gtt aaa cag aat       1626
Lys Thr Thr Leu Glu Ser Leu Thr Gln Gln Leu Ala Val Lys Gln Asn           
            380                 385                 390                   

gaa gaa gga aaa ttt agc cat gca atg atg gat ttc aat ctg agt gga       1674
Glu Glu Gly Lys Phe Ser His Ala Met Met Asp Phe Asn Leu Ser Gly           
        395                 400                 405                       

gat tct gat gga agt gct gga gtc tca gag tca aga att tat agg gaa       1722
Asp Ser Asp Gly Ser Ala Gly Val Ser Glu Ser Arg Ile Tyr Arg Glu           
    410                 415                 420                           

tcc cga ggg cgt ggt agc aat gaa ccc cac ata aag cgt cca atg aat       1770
Ser Arg Gly Arg Gly Ser Asn Glu Pro His Ile Lys Arg Pro Met Asn           
425                 430                 435                 440           

gcc ttc atg gtg tgg gct aaa gat gaa cgg aga aag atc ctt caa gcc       1818
Ala Phe Met Val Trp Ala Lys Asp Glu Arg Arg Lys Ile Leu Gln Ala           
                445                 450                 455               

ttt cct gac atg cac aac tcc aac atc agc aag ata ttg gga tct cgc       1866
Phe Pro Asp Met His Asn Ser Asn Ile Ser Lys Ile Leu Gly Ser Arg           
            460                 465                 470                   

tgg aaa gct atg aca aac cta gag aaa cag cca tat tat gag gag caa       1914
Trp Lys Ala Met Thr Asn Leu Glu Lys Gln Pro Tyr Tyr Glu Glu Gln           
        475                 480                 485                       

gcc cgt ctc agc aag cag cac ctg gag aag tac cct gac tat aag tac       1962
Ala Arg Leu Ser Lys Gln His Leu Glu Lys Tyr Pro Asp Tyr Lys Tyr           
    490                 495                 500                           

aag ccc agg cca aag cgc acc tgc ctg gtg gat ggc aaa aag ctg cgc       2010
Lys Pro Arg Pro Lys Arg Thr Cys Leu Val Asp Gly Lys Lys Leu Arg           
505                 510                 515                 520           

att ggt gaa tac aag gca atc atg cgc aac agg cgg cag gaa atg cgg       2058
Ile Gly Glu Tyr Lys Ala Ile Met Arg Asn Arg Arg Gln Glu Met Arg           
                525                 530                 535               

cag tac ttc aat gtt ggg caa caa gca cag atc ccc att gcc act gct       2106
Gln Tyr Phe Asn Val Gly Gln Gln Ala Gln Ile Pro Ile Ala Thr Ala           
            540                 545                 550                   

ggt gtt gtg tac cct gga gcc atc gcc atg gct ggg atg ccc tcc cct       2154
Gly Val Val Tyr Pro Gly Ala Ile Ala Met Ala Gly Met Pro Ser Pro           
        555                 560                 565                       

cac ctg ccc tcg gag cac tca agc gtg tct agc agc cca gag cct ggg       2202
His Leu Pro Ser Glu His Ser Ser Val Ser Ser Ser Pro Glu Pro Gly           
    570                 575                 580                           

atg cct gtt atc cag agc act tac ggt gtg aaa gga gag gag cca cat       2250
Met Pro Val Ile Gln Ser Thr Tyr Gly Val Lys Gly Glu Glu Pro His           
585                 590                 595                 600           

atc aaa gaa gag ata cag gcc gag gac atc aat gga gaa att tat gat       2298
Ile Lys Glu Glu Ile Gln Ala Glu Asp Ile Asn Gly Glu Ile Tyr Asp           
                605                 610                 615               

gag tac gac gag gaa gag gat gat cca gat gta gat tat ggg agt gac       2346
Glu Tyr Asp Glu Glu Glu Asp Asp Pro Asp Val Asp Tyr Gly Ser Asp           
            620                 625                 630                   

agt gaa aac cat att gca gga caa gcc aac tga taagggtcaa aagattgttg     2399
Ser Glu Asn His Ile Ala Gly Gln Ala Asn                                   
        635                 640                                           

tgaccttagg acttaaagaa gccctaactg gttcatcctt accagtggcc aagcacatta     2459

actttctcat acactgactg ttactttaac tgttagtctt aaatagttgg gacatcagct     2519

gactaataga cctcagcctc aaaaggcttg gaaagaaaaa acaaatacaa caagcaaaca     2579

acaatatcaa caacaagaga ttgaaataag ctatgggtaa aataatgcca gtaattcagc     2639

tgctacatcc aagcactgaa gtcttacccg tcaacttttt ttttttttaa ataaacttta     2699

tggctgtttg ttctacaatg ttctagaaat tctcactcag gtacacagtg ccaacaagtg     2759

gcttgtgaat gtgttttgtt gttttgtgct acaattttta aaaaaaaaaa aaaaa          2814


<210>  58
<211>  642
<212>  PRT
<213>  Homo sapiens - SRY-box 5

<400>  58

Met Ser Ser Lys Arg Pro Ala Ser Pro Tyr Gly Glu Ala Asp Gly Glu 
1               5                   10                  15      


Val Ala Met Val Thr Ser Arg Gln Lys Val Glu Glu Glu Glu Ser Asp 
            20                  25                  30          


Gly Leu Pro Ala Phe His Leu Pro Leu His Val Ser Phe Pro Asn Lys 
        35                  40                  45              


Pro His Ser Glu Glu Phe Gln Pro Val Ser Leu Leu Thr Gln Glu Thr 
    50                  55                  60                  


Cys Gly His Arg Thr Pro Thr Ser Gln His Asn Thr Met Glu Val Asp 
65                  70                  75                  80  


Gly Asn Lys Val Met Ser Ser Phe Ala Pro His Asn Ser Ser Thr Ser 
                85                  90                  95      


Pro Gln Lys Ala Glu Glu Gly Gly Arg Gln Ser Gly Glu Ser Leu Ser 
            100                 105                 110         


Ser Thr Ala Leu Gly Thr Pro Glu Arg Arg Lys Gly Ser Leu Ala Asp 
        115                 120                 125             


Val Val Asp Thr Leu Lys Gln Arg Lys Met Glu Glu Leu Ile Lys Asn 
    130                 135                 140                 


Glu Pro Glu Glu Thr Pro Ser Ile Glu Lys Leu Leu Ser Lys Asp Trp 
145                 150                 155                 160 


Lys Asp Lys Leu Leu Ala Met Gly Ser Gly Asn Phe Gly Glu Ile Lys 
                165                 170                 175     


Gly Thr Pro Glu Ser Leu Ala Glu Lys Glu Arg Gln Leu Met Gly Met 
            180                 185                 190         


Ile Asn Gln Leu Thr Ser Leu Arg Glu Gln Leu Leu Ala Ala His Asp 
        195                 200                 205             


Glu Gln Lys Lys Leu Ala Ala Ser Gln Ile Glu Lys Gln Arg Gln Gln 
    210                 215                 220                 


Met Glu Leu Ala Lys Gln Gln Gln Glu Gln Ile Ala Arg Gln Gln Gln 
225                 230                 235                 240 


Gln Leu Leu Gln Gln Gln His Lys Ile Asn Leu Leu Gln Gln Gln Ile 
                245                 250                 255     


Gln Val Gln Gly Gln Leu Pro Pro Leu Met Ile Pro Val Phe Pro Pro 
            260                 265                 270         


Asp Gln Arg Thr Leu Ala Ala Ala Ala Gln Gln Gly Phe Leu Leu Pro 
        275                 280                 285             


Pro Gly Phe Ser Tyr Lys Ala Gly Cys Ser Asp Pro Tyr Pro Val Gln 
    290                 295                 300                 


Leu Ile Pro Thr Thr Met Ala Ala Ala Ala Ala Ala Thr Pro Gly Leu 
305                 310                 315                 320 


Gly Pro Leu Gln Leu Gln Gln Leu Tyr Ala Ala Gln Leu Ala Ala Met 
                325                 330                 335     


Gln Val Ser Pro Gly Gly Lys Leu Pro Gly Ile Pro Gln Gly Asn Leu 
            340                 345                 350         


Gly Ala Ala Val Ser Pro Thr Ser Ile His Thr Asp Lys Ser Thr Asn 
        355                 360                 365             


Ser Pro Pro Pro Lys Ser Lys Glu Lys Thr Thr Leu Glu Ser Leu Thr 
    370                 375                 380                 


Gln Gln Leu Ala Val Lys Gln Asn Glu Glu Gly Lys Phe Ser His Ala 
385                 390                 395                 400 


Met Met Asp Phe Asn Leu Ser Gly Asp Ser Asp Gly Ser Ala Gly Val 
                405                 410                 415     


Ser Glu Ser Arg Ile Tyr Arg Glu Ser Arg Gly Arg Gly Ser Asn Glu 
            420                 425                 430         


Pro His Ile Lys Arg Pro Met Asn Ala Phe Met Val Trp Ala Lys Asp 
        435                 440                 445             


Glu Arg Arg Lys Ile Leu Gln Ala Phe Pro Asp Met His Asn Ser Asn 
    450                 455                 460                 


Ile Ser Lys Ile Leu Gly Ser Arg Trp Lys Ala Met Thr Asn Leu Glu 
465                 470                 475                 480 


Lys Gln Pro Tyr Tyr Glu Glu Gln Ala Arg Leu Ser Lys Gln His Leu 
                485                 490                 495     


Glu Lys Tyr Pro Asp Tyr Lys Tyr Lys Pro Arg Pro Lys Arg Thr Cys 
            500                 505                 510         


Leu Val Asp Gly Lys Lys Leu Arg Ile Gly Glu Tyr Lys Ala Ile Met 
        515                 520                 525             


Arg Asn Arg Arg Gln Glu Met Arg Gln Tyr Phe Asn Val Gly Gln Gln 
    530                 535                 540                 


Ala Gln Ile Pro Ile Ala Thr Ala Gly Val Val Tyr Pro Gly Ala Ile 
545                 550                 555                 560 


Ala Met Ala Gly Met Pro Ser Pro His Leu Pro Ser Glu His Ser Ser 
                565                 570                 575     


Val Ser Ser Ser Pro Glu Pro Gly Met Pro Val Ile Gln Ser Thr Tyr 
            580                 585                 590         


Gly Val Lys Gly Glu Glu Pro His Ile Lys Glu Glu Ile Gln Ala Glu 
        595                 600                 605             


Asp Ile Asn Gly Glu Ile Tyr Asp Glu Tyr Asp Glu Glu Glu Asp Asp 
    610                 615                 620                 


Pro Asp Val Asp Tyr Gly Ser Asp Ser Glu Asn His Ile Ala Gly Gln 
625                 630                 635                 640 


Ala Asn 
        


<210>  59
<211>  1959
<212>  DNA
<213>  Mus musculus - Carbonic anhydrase 9


<220>
<221>  CDS
<222>  (31)..(1344)

<400>  59
agtgtgtcct gggacacccc agtcagctgc atg gcc tcc ctg ggc ccc agc ccc        54
                                 Met Ala Ser Leu Gly Pro Ser Pro          
                                 1               5                        

tgg gcc cct ttg tcg acc cca gcc cct act gca cag ctg ctg ctg ttc        102
Trp Ala Pro Leu Ser Thr Pro Ala Pro Thr Ala Gln Leu Leu Leu Phe           
    10                  15                  20                            

ctg ctg ctc caa gtg tct gct cag ccc cag ggc ctg tcc ggg atg cag        150
Leu Leu Leu Gln Val Ser Ala Gln Pro Gln Gly Leu Ser Gly Met Gln           
25                  30                  35                  40            

ggg gag ccc tcc ttg gga gac agt tca tct ggg gag gat gag ctg ggc        198
Gly Glu Pro Ser Leu Gly Asp Ser Ser Ser Gly Glu Asp Glu Leu Gly           
                45                  50                  55                

gtg gat gtt ctg ccc agt gaa gag gat gca cct gaa gag gcg gat cca        246
Val Asp Val Leu Pro Ser Glu Glu Asp Ala Pro Glu Glu Ala Asp Pro           
            60                  65                  70                    

ccc gat ggg gag gat cca cct gaa gtt aat tct gaa gac agg atg gag        294
Pro Asp Gly Glu Asp Pro Pro Glu Val Asn Ser Glu Asp Arg Met Glu           
        75                  80                  85                        

gag tcc ctt ggg tta gag gat cta tcg act ccc gag gct cct gag cac        342
Glu Ser Leu Gly Leu Glu Asp Leu Ser Thr Pro Glu Ala Pro Glu His           
    90                  95                  100                           

agt caa ggt tcc cac ggg gat gaa aaa ggg ggt ggc cac agt cat tgg        390
Ser Gln Gly Ser His Gly Asp Glu Lys Gly Gly Gly His Ser His Trp           
105                 110                 115                 120           

agc tat gga ggc acc cta ctc tgg ccc cag gtg tcc cca gcc tgt gct        438
Ser Tyr Gly Gly Thr Leu Leu Trp Pro Gln Val Ser Pro Ala Cys Ala           
                125                 130                 135               

ggc cgc ttt cag tcc ccg gta gac atc cgc ctg gag cgc acc gca ttc        486
Gly Arg Phe Gln Ser Pro Val Asp Ile Arg Leu Glu Arg Thr Ala Phe           
            140                 145                 150                   

tgc cgc act ctg caa ccc ctg gaa ctt ctg ggt tat gag ctc cag cct        534
Cys Arg Thr Leu Gln Pro Leu Glu Leu Leu Gly Tyr Glu Leu Gln Pro           
        155                 160                 165                       

ctc ccg gaa ctg agc cta tcc aac aat ggc cac acg gta cag ctg act        582
Leu Pro Glu Leu Ser Leu Ser Asn Asn Gly His Thr Val Gln Leu Thr           
    170                 175                 180                           

ctg ccg ccg ggg ctg aag atg gct ctg gga cct ggg cag gaa tac cgg        630
Leu Pro Pro Gly Leu Lys Met Ala Leu Gly Pro Gly Gln Glu Tyr Arg           
185                 190                 195                 200           

gcc ttg cag ttg cat cta cac tgg gga act tca gat cac cca ggc tca        678
Ala Leu Gln Leu His Leu His Trp Gly Thr Ser Asp His Pro Gly Ser           
                205                 210                 215               

gaa cac aca gtc aat ggt cac cgt ttc cct gct gag atc cac gtg gtg        726
Glu His Thr Val Asn Gly His Arg Phe Pro Ala Glu Ile His Val Val           
            220                 225                 230                   

cac ctc agt act gct ttc tcc gaa ctt cat gaa gcc ttg ggc cgc cca        774
His Leu Ser Thr Ala Phe Ser Glu Leu His Glu Ala Leu Gly Arg Pro           
        235                 240                 245                       

gga ggc ctg gca gtt ttg gct gcc ttt ctg cag gag agc cca gaa gaa        822
Gly Gly Leu Ala Val Leu Ala Ala Phe Leu Gln Glu Ser Pro Glu Glu           
    250                 255                 260                           

aac agt gct tac gaa cag ttg ctg tcc cat ttg gaa gaa atc tcg gag        870
Asn Ser Ala Tyr Glu Gln Leu Leu Ser His Leu Glu Glu Ile Ser Glu           
265                 270                 275                 280           

gaa ggc tcc aag att gag atc cca ggt ttg gat gta tct gca ctg ttg        918
Glu Gly Ser Lys Ile Glu Ile Pro Gly Leu Asp Val Ser Ala Leu Leu           
                285                 290                 295               

ccc tcg gac ctc agc cgc tac tac cga tat gaa ggg tct ctg acc aca        966
Pro Ser Asp Leu Ser Arg Tyr Tyr Arg Tyr Glu Gly Ser Leu Thr Thr           
            300                 305                 310                   

cct ccc tgc agc cag ggg gtc atc tgg act gtg ttc aat gag aca gtg       1014
Pro Pro Cys Ser Gln Gly Val Ile Trp Thr Val Phe Asn Glu Thr Val           
        315                 320                 325                       

aaa ctg agc gct aag cag ctc cat act ctc tcc gtt tcc ttg tgg gga       1062
Lys Leu Ser Ala Lys Gln Leu His Thr Leu Ser Val Ser Leu Trp Gly           
    330                 335                 340                           

cct cgt gat tct cgg cta caa ctg aac ttc cga gcc acg caa ccc ttg       1110
Pro Arg Asp Ser Arg Leu Gln Leu Asn Phe Arg Ala Thr Gln Pro Leu           
345                 350                 355                 360           

aat ggg cga acg att gag gct tcc ttc cct gct gca gag gat agc agc       1158
Asn Gly Arg Thr Ile Glu Ala Ser Phe Pro Ala Ala Glu Asp Ser Ser           
                365                 370                 375               

cct gag cca gtc cat gtg aat tcc tgc ttc act gct ggt gac atc cta       1206
Pro Glu Pro Val His Val Asn Ser Cys Phe Thr Ala Gly Asp Ile Leu           
            380                 385                 390                   

gcc ttg gtg ttt ggc ctt ctc ttt gct gtc acc agc atc gcc ttc ctc       1254
Ala Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Ile Ala Phe Leu           
        395                 400                 405                       

cta cag ctg agg agg cag cac agg cac aga agt ggg acc aaa gat aga       1302
Leu Gln Leu Arg Arg Gln His Arg His Arg Ser Gly Thr Lys Asp Arg           
    410                 415                 420                           

gtt agc tac agt ccg gca gag atg aca gaa act gga gcc taa               1344
Val Ser Tyr Ser Pro Ala Glu Met Thr Glu Thr Gly Ala                       
425                 430                 435                               

taaggagaaa ccagctaaag gaatctggaa accttgtcct gtcctgcctg ttatacagcc     1404

tcctttttaa ccactacgaa atcatttcca tctttttaac tttcttcttt ccttaaagta     1464

ctgtgatagg agctaaccgt gaaaaaacaa gattgggctc aattcttgct gggttttgat     1524

ggttttgaag acagggtttc tctgtgtagc cctggctgtc ctgggactca ctctgtagcc     1584

taggctggcc ttgaactcag agatccgatt gcctctgcct tcttagtgcc aggactgagg     1644

gtatgtacca ctaccaccgc caccccgcaa ttcttgcttt tattctgcag tcaaatgctc     1704

taccactgag ctacacaccc ctccatctta ctatgcaggc agactggcct tgcattgtgt     1764

atgtatggtg atggagtttg aagccagggt cttacctact aggcaagcgt tctatcactg     1824

acctaagcct ctctagtccc ttctcttgaa ccctctattc tcctgtccca gcctcttgaa     1884

tgctgggatt acaggaatgc accatcatgc ttggtcatcc caattattta aaaaaaatat     1944

ataaatcttc ctagt                                                      1959


<210>  60
<211>  437
<212>  PRT
<213>  Mus musculus - Carbonic anhydrase 9

<400>  60

Met Ala Ser Leu Gly Pro Ser Pro Trp Ala Pro Leu Ser Thr Pro Ala 
1               5                   10                  15      


Pro Thr Ala Gln Leu Leu Leu Phe Leu Leu Leu Gln Val Ser Ala Gln 
            20                  25                  30          


Pro Gln Gly Leu Ser Gly Met Gln Gly Glu Pro Ser Leu Gly Asp Ser 
        35                  40                  45              


Ser Ser Gly Glu Asp Glu Leu Gly Val Asp Val Leu Pro Ser Glu Glu 
    50                  55                  60                  


Asp Ala Pro Glu Glu Ala Asp Pro Pro Asp Gly Glu Asp Pro Pro Glu 
65                  70                  75                  80  


Val Asn Ser Glu Asp Arg Met Glu Glu Ser Leu Gly Leu Glu Asp Leu 
                85                  90                  95      


Ser Thr Pro Glu Ala Pro Glu His Ser Gln Gly Ser His Gly Asp Glu 
            100                 105                 110         


Lys Gly Gly Gly His Ser His Trp Ser Tyr Gly Gly Thr Leu Leu Trp 
        115                 120                 125             


Pro Gln Val Ser Pro Ala Cys Ala Gly Arg Phe Gln Ser Pro Val Asp 
    130                 135                 140                 


Ile Arg Leu Glu Arg Thr Ala Phe Cys Arg Thr Leu Gln Pro Leu Glu 
145                 150                 155                 160 


Leu Leu Gly Tyr Glu Leu Gln Pro Leu Pro Glu Leu Ser Leu Ser Asn 
                165                 170                 175     


Asn Gly His Thr Val Gln Leu Thr Leu Pro Pro Gly Leu Lys Met Ala 
            180                 185                 190         


Leu Gly Pro Gly Gln Glu Tyr Arg Ala Leu Gln Leu His Leu His Trp 
        195                 200                 205             


Gly Thr Ser Asp His Pro Gly Ser Glu His Thr Val Asn Gly His Arg 
    210                 215                 220                 


Phe Pro Ala Glu Ile His Val Val His Leu Ser Thr Ala Phe Ser Glu 
225                 230                 235                 240 


Leu His Glu Ala Leu Gly Arg Pro Gly Gly Leu Ala Val Leu Ala Ala 
                245                 250                 255     


Phe Leu Gln Glu Ser Pro Glu Glu Asn Ser Ala Tyr Glu Gln Leu Leu 
            260                 265                 270         


Ser His Leu Glu Glu Ile Ser Glu Glu Gly Ser Lys Ile Glu Ile Pro 
        275                 280                 285             


Gly Leu Asp Val Ser Ala Leu Leu Pro Ser Asp Leu Ser Arg Tyr Tyr 
    290                 295                 300                 


Arg Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys Ser Gln Gly Val Ile 
305                 310                 315                 320 


Trp Thr Val Phe Asn Glu Thr Val Lys Leu Ser Ala Lys Gln Leu His 
                325                 330                 335     


Thr Leu Ser Val Ser Leu Trp Gly Pro Arg Asp Ser Arg Leu Gln Leu 
            340                 345                 350         


Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg Thr Ile Glu Ala Ser 
        355                 360                 365             


Phe Pro Ala Ala Glu Asp Ser Ser Pro Glu Pro Val His Val Asn Ser 
    370                 375                 380                 


Cys Phe Thr Ala Gly Asp Ile Leu Ala Leu Val Phe Gly Leu Leu Phe 
385                 390                 395                 400 


Ala Val Thr Ser Ile Ala Phe Leu Leu Gln Leu Arg Arg Gln His Arg 
                405                 410                 415     


His Arg Ser Gly Thr Lys Asp Arg Val Ser Tyr Ser Pro Ala Glu Met 
            420                 425                 430         


Thr Glu Thr Gly Ala 
        435         


<210>  61
<211>  1639
<212>  DNA
<213>  Homo sapiens - Carbonic anhydrase IX


<220>
<221>  CDS
<222>  (105)..(1484)

<220>
<221>  misc_difference
<222>  (201)..(201)
<223>  'A' in cDNA is 'G' in the human genome; amino acid difference: 
       'M' in cDNA, 'V' in the human genome.  The chimpanzee genome 
       agrees with the human genomic sequence and not the cDNA.

<400>  61
cagcctgctc ccctccaggc ttgctcctcc cccacccagc tctcgtttcc aatgcacgta       60

cagcccgtac acaccgtgtg ctgggacacc ccacagtcag ccgc atg gct ccc ctg       116
                                                 Met Ala Pro Leu          
                                                 1                        

tgc ccc agc ccc tgg ctc cct ctg ttg atc ccg gcc cct gct cca ggc        164
Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala Pro Ala Pro Gly           
5                   10                  15                  20            

ctc act gtg caa ctg ctg ctg tca ctg ctg ctt ctg atg cct gtc cat        212
Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu Met Pro Val His           
                25                  30                  35                

ccc cag agg ttg ccc cgg atg cag gag gat tcc ccc ttg gga gga ggc        260
Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro Leu Gly Gly Gly           
            40                  45                  50                    

tct tct ggg gaa gat gac cca ctg ggc gag gag gat ctg ccc agt gaa        308
Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp Leu Pro Ser Glu           
        55                  60                  65                        

gag gat tca ccc aga gag gag gat cca ccc gga gag gag gat cta cct        356
Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu Glu Asp Leu Pro           
    70                  75                  80                            

gga gag gag gat cta cct gga gag gag gat cta cct gaa gtt aag cct        404
Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Glu Val Lys Pro           
85                  90                  95                  100           

aaa tca gaa gaa gag ggc tcc ctg aag tta gag gat cta cct act gtt        452
Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp Leu Pro Thr Val           
                105                 110                 115               

gag gct cct gga gat cct caa gaa ccc cag aat aat gcc cac agg gac        500
Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn Ala His Arg Asp           
            120                 125                 130                   

aaa gaa ggg gat gac cag agt cat tgg cgc tat gga ggc gac ccg ccc        548
Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly Gly Asp Pro Pro           
        135                 140                 145                       

tgg ccc cgg gtg tcc cca gcc tgc gcg ggc cgc ttc cag tcc ccg gtg        596
Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe Gln Ser Pro Val           
    150                 155                 160                           

gat atc cgc ccc cag ctc gcc gcc ttc tgc ccg gcc ctg cgc ccc ctg        644
Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala Leu Arg Pro Leu           
165                 170                 175                 180           

gaa ctc ctg ggc ttc cag ctc ccg ccg ctc cca gaa ctg cgc ctg cgc        692
Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu Leu Arg Leu Arg           
                185                 190                 195               

aac aat ggc cac agt gtg caa ctg acc ctg cct cct ggg cta gag atg        740
Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro Gly Leu Glu Met           
            200                 205                 210                   

gct ctg ggt ccc ggg cgg gag tac cgg gct ctg cag ctg cat ctg cac        788
Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln Leu His Leu His           
        215                 220                 225                       

tgg ggg gct gca ggt cgt ccg ggc tcg gag cac act gtg gaa ggc cac        836
Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr Val Glu Gly His           
    230                 235                 240                           

cgt ttc cct gcc gag atc cac gtg gtt cac ctc agc acc gcc ttt gcc        884
Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser Thr Ala Phe Ala           
245                 250                 255                 260           

aga gtt gac gag gcc ttg ggg cgc ccg gga ggc ctg gcc gtg ttg gcc        932
Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu Ala Val Leu Ala           
                265                 270                 275               

gcc ttt ctg gag gag ggc ccg gaa gaa aac agt gcc tat gag cag ttg        980
Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala Tyr Glu Gln Leu           
            280                 285                 290                   

ctg tct cgc ttg gaa gaa atc gct gag gaa ggc tca gag act cag gtc       1028
Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser Glu Thr Gln Val           
        295                 300                 305                       

cca gga ctg gac ata tct gca ctc ctg ccc tct gac ttc agc cgc tac       1076
Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp Phe Ser Arg Tyr           
    310                 315                 320                           

ttc caa tat gag ggg tct ctg act aca ccg ccc tgt gcc cag ggt gtc       1124
Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys Ala Gln Gly Val           
325                 330                 335                 340           

atc tgg act gtg ttt aac cag aca gtg atg ctg agt gct aag cag ctc       1172
Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser Ala Lys Gln Leu           
                345                 350                 355               

cac acc ctc tct gac acc ctg tgg gga cct ggt gac tct cgg cta cag       1220
His Thr Leu Ser Asp Thr Leu Trp Gly Pro Gly Asp Ser Arg Leu Gln           
            360                 365                 370                   

ctg aac ttc cga gcg acg cag cct ttg aat ggg cga gtg att gag gcc       1268
Leu Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg Val Ile Glu Ala           
        375                 380                 385                       

tcc ttc cct gct gga gtg gac agc agt cct cgg gct gct gag cca gtc       1316
Ser Phe Pro Ala Gly Val Asp Ser Ser Pro Arg Ala Ala Glu Pro Val           
    390                 395                 400                           

cag ctg aat tcc tgc ctg gct gct ggt gac atc cta gcc ctg gtt ttt       1364
Gln Leu Asn Ser Cys Leu Ala Ala Gly Asp Ile Leu Ala Leu Val Phe           
405                 410                 415                 420           

ggc ctc ctt ttt gct gtc acc agc gtc gcg ttc ctt gtg cag atg aga       1412
Gly Leu Leu Phe Ala Val Thr Ser Val Ala Phe Leu Val Gln Met Arg           
                425                 430                 435               

agg cag cac aga agg gga acc aaa ggg ggt gtg agc tac cgc cca gca       1460
Arg Gln His Arg Arg Gly Thr Lys Gly Gly Val Ser Tyr Arg Pro Ala           
            440                 445                 450                   

gag gta gcc gag act gga gcc tag aggctggatc ttggagaatg tgagaagcca      1514
Glu Val Ala Glu Thr Gly Ala                                               
        455                                                               

gccagaggca tctgaggggg agccggtaac tgtcctgtcc tgctcattat gccacttcct     1574

tttaactgca aagaaatttt ttaaaataaa tatttataat aaaaaaaaaa aaaaaaaaaa     1634

aaaaa                                                                 1639


<210>  62
<211>  459
<212>  PRT
<213>  Homo sapiens - Carbonic anhydrase IX

<400>  62

Met Ala Pro Leu Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala 
1               5                   10                  15      


Pro Ala Pro Gly Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu 
            20                  25                  30          


Met Pro Val His Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro 
        35                  40                  45              


Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp 
    50                  55                  60                  


Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu 
65                  70                  75                  80  


Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 
                85                  90                  95      


Glu Val Lys Pro Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp 
            100                 105                 110         


Leu Pro Thr Val Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn 
        115                 120                 125             


Ala His Arg Asp Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly 
    130                 135                 140                 


Gly Asp Pro Pro Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe 
145                 150                 155                 160 


Gln Ser Pro Val Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala 
                165                 170                 175     


Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu 
            180                 185                 190         


Leu Arg Leu Arg Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro 
        195                 200                 205             


Gly Leu Glu Met Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln 
    210                 215                 220                 


Leu His Leu His Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr 
225                 230                 235                 240 


Val Glu Gly His Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser 
                245                 250                 255     


Thr Ala Phe Ala Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu 
            260                 265                 270         


Ala Val Leu Ala Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala 
        275                 280                 285             


Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser 
    290                 295                 300                 


Glu Thr Gln Val Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp 
305                 310                 315                 320 


Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys 
                325                 330                 335     


Ala Gln Gly Val Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser 
            340                 345                 350         


Ala Lys Gln Leu His Thr Leu Ser Asp Thr Leu Trp Gly Pro Gly Asp 
        355                 360                 365             


Ser Arg Leu Gln Leu Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg 
    370                 375                 380                 


Val Ile Glu Ala Ser Phe Pro Ala Gly Val Asp Ser Ser Pro Arg Ala 
385                 390                 395                 400 


Ala Glu Pro Val Gln Leu Asn Ser Cys Leu Ala Ala Gly Asp Ile Leu 
                405                 410                 415     


Ala Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Ala Phe Leu 
            420                 425                 430         


Val Gln Met Arg Arg Gln His Arg Arg Gly Thr Lys Gly Gly Val Ser 
        435                 440                 445             


Tyr Arg Pro Ala Glu Val Ala Glu Thr Gly Ala 
    450                 455                 


<210>  63
<211>  2060
<212>  DNA
<213>  Mus musculus - Aldehyde dehydrogenase family 1, subfamily A7


<220>
<221>  CDS
<222>  (45)..(1550)

<400>  63
attttgctga gcctgtcact tgtgttccag gagccaaacc agca atg tct tca cct        56
                                                 Met Ser Ser Pro          
                                                 1                        

gca caa cct gca gtc cct gcc ccg ctg gcc aac ttg aag att caa cat        104
Ala Gln Pro Ala Val Pro Ala Pro Leu Ala Asn Leu Lys Ile Gln His           
5                   10                  15                  20            

acc aag atc ttt ata aac aat gaa tgg cat gat tcg gtg agc agc aag        152
Thr Lys Ile Phe Ile Asn Asn Glu Trp His Asp Ser Val Ser Ser Lys           
                25                  30                  35                

aaa ttt cct gtc ctt aac cct gca act gag gag gtc atc tgc cac gtg        200
Lys Phe Pro Val Leu Asn Pro Ala Thr Glu Glu Val Ile Cys His Val           
            40                  45                  50                    

gaa gaa ggg gac aag gct gat gtt gac aaa gct gtg aag gcc gca aga        248
Glu Glu Gly Asp Lys Ala Asp Val Asp Lys Ala Val Lys Ala Ala Arg           
        55                  60                  65                        

cag gct ttc cag att ggc tcc cca tgg cgc acc atg gat gct tca gag        296
Gln Ala Phe Gln Ile Gly Ser Pro Trp Arg Thr Met Asp Ala Ser Glu           
    70                  75                  80                            

agg ggc cgc ctg ctg aac aag ctg gct gac tta atg gag aga gat cgt        344
Arg Gly Arg Leu Leu Asn Lys Leu Ala Asp Leu Met Glu Arg Asp Arg           
85                  90                  95                  100           

ctg ctg ctg gct aca atg gaa tcg atg aat gct ggg aaa gtc ttt gct        392
Leu Leu Leu Ala Thr Met Glu Ser Met Asn Ala Gly Lys Val Phe Ala           
                105                 110                 115               

cat gca tac ctg ttg gat gta gag atc agc ata aaa gca tta cag tac        440
His Ala Tyr Leu Leu Asp Val Glu Ile Ser Ile Lys Ala Leu Gln Tyr           
            120                 125                 130                   

ttc gca ggc tgg gct gac aag atc cat ggc caa aca ata ccc agt gat        488
Phe Ala Gly Trp Ala Asp Lys Ile His Gly Gln Thr Ile Pro Ser Asp           
        135                 140                 145                       

gga aac ata ttc act tat aca agg cgt gaa cct att ggg gtg tgt ggc        536
Gly Asn Ile Phe Thr Tyr Thr Arg Arg Glu Pro Ile Gly Val Cys Gly           
    150                 155                 160                           

caa atc atc cct tgg aat ggt cca ttg att ata ttc act tgg aag tta        584
Gln Ile Ile Pro Trp Asn Gly Pro Leu Ile Ile Phe Thr Trp Lys Leu           
165                 170                 175                 180           

ggc cct gcc ctt agc tgt ggg aac act gtg gtt gtc aag cca gca gag        632
Gly Pro Ala Leu Ser Cys Gly Asn Thr Val Val Val Lys Pro Ala Glu           
                185                 190                 195               

caa act cct ctc aca gct ctt cac atg gca tct tta ata aaa gag gca        680
Gln Thr Pro Leu Thr Ala Leu His Met Ala Ser Leu Ile Lys Glu Ala           
            200                 205                 210                   

ggg ttt cct cct ggc gtg gtg aac att gtc cct ggt tat ggg cca act        728
Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly Tyr Gly Pro Thr           
        215                 220                 225                       

gca ggg gga gcc atc tcc tcc cac atg gac atc gac aaa gtg tcc ttc        776
Ala Gly Gly Ala Ile Ser Ser His Met Asp Ile Asp Lys Val Ser Phe           
    230                 235                 240                           

aca gga tca aca gag gtt ggc aaa tta atc aag gaa gct gca ggg aaa        824
Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Lys Glu Ala Ala Gly Lys           
245                 250                 255                 260           

agc aat ctg aag aga gtc acc ctg gag ctg ggg gga aag agc cct tgc        872
Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Cys           
                265                 270                 275               

att gtg ttt gca gat gcc gac ttg gac agt gct gtt gag ttt gca cac        920
Ile Val Phe Ala Asp Ala Asp Leu Asp Ser Ala Val Glu Phe Ala His           
            280                 285                 290                   

caa gga gtg ttc ttc cac cag ggt cag att tgt gtt gca gcg tcc agg        968
Gln Gly Val Phe Phe His Gln Gly Gln Ile Cys Val Ala Ala Ser Arg           
        295                 300                 305                       

ctt ttt gtt gag gaa tca att tac gat gag ttt gtg agg agg agt gtg       1016
Leu Phe Val Glu Glu Ser Ile Tyr Asp Glu Phe Val Arg Arg Ser Val           
    310                 315                 320                           

gag cgg gct aag aaa tac att cta gga aat cct ctg aac tcc gga ata       1064
Glu Arg Ala Lys Lys Tyr Ile Leu Gly Asn Pro Leu Asn Ser Gly Ile           
325                 330                 335                 340           

aat caa ggt cct cag att gac aag gaa caa cac aat aaa ata ctt ggt       1112
Asn Gln Gly Pro Gln Ile Asp Lys Glu Gln His Asn Lys Ile Leu Gly           
                345                 350                 355               

ctc att gag agt ggg aag aaa gaa gga gcc aag ctg gag tgt ggt gga       1160
Leu Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu Glu Cys Gly Gly           
            360                 365                 370                   

ggt cgc tgg ggg aac aaa ggc ttc ttt gtc caa ccc aca gtc ttc tcc       1208
Gly Arg Trp Gly Asn Lys Gly Phe Phe Val Gln Pro Thr Val Phe Ser           
        375                 380                 385                       

aat gtg act gat gag atg cgc att gcc aaa gag gag ata ttt gga cca       1256
Asn Val Thr Asp Glu Met Arg Ile Ala Lys Glu Glu Ile Phe Gly Pro           
    390                 395                 400                           

gtg caa caa atc atg aag ttt aaa tct atg gat gat gtg atc aag aga       1304
Val Gln Gln Ile Met Lys Phe Lys Ser Met Asp Asp Val Ile Lys Arg           
405                 410                 415                 420           

gca aac aac act acc tat ggt tta gca gca gga gtc ttc act aaa gac       1352
Ala Asn Asn Thr Thr Tyr Gly Leu Ala Ala Gly Val Phe Thr Lys Asp           
                425                 430                 435               

ctg gat aag gcc atc act gtg tca tct gct ctg cag gct ggg atg gtg       1400
Leu Asp Lys Ala Ile Thr Val Ser Ser Ala Leu Gln Ala Gly Met Val           
            440                 445                 450                   

tgg gtg aac tgc tat ttg gct gtc cct gtc caa tgc cca ttt ggt gga       1448
Trp Val Asn Cys Tyr Leu Ala Val Pro Val Gln Cys Pro Phe Gly Gly           
        455                 460                 465                       

ttc aag atg tct gga aat ggg cga gaa ctg ggc gaa cat ggt ctt tat       1496
Phe Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu His Gly Leu Tyr           
    470                 475                 480                           

gaa tac act gag ctc aag aca gtt gca atg caa ata tct cag aag aac       1544
Glu Tyr Thr Glu Leu Lys Thr Val Ala Met Gln Ile Ser Gln Lys Asn           
485                 490                 495                 500           

tca taa agaagccagc agagtgaaga gaaactctca gcagtggctg tacatctcat        1600
Ser                                                                       
                                                                          

acagtcacca gaaagtggtg ttttgctata agttcttctt ctgttgagtt ctttaaacgt     1660

aaggaattca tcagtattac tgttaatcat agaaaagacg tagcttaatc tggcagaatc     1720

agagtcttct aatccgtgaa cccaattcat atcccagaac aaaaggatac attaaggtgc     1780

aagctctctg taactctgtc atgataaggt gctttccatt gtagctactt gtctagagta     1840

cacacttggc aaggaggacc agtcctgatt taagctctgt cccacactga ttccttgaac     1900

tacgtaccat gcatgataac tgaaaagtta gctgctctat tcctcggggt tattcctctg     1960

agtgttgtga aatattttcc agaatgccat gactgcttgt caaatgaaat gcctccctgt     2020

aattcgaatg caaagcttaa taaaggcaat ctcgcatgat                           2060


<210>  64
<211>  501
<212>  PRT
<213>  Mus musculus - Aldehyde dehydrogenase family 1, subfamily A7

<400>  64

Met Ser Ser Pro Ala Gln Pro Ala Val Pro Ala Pro Leu Ala Asn Leu 
1               5                   10                  15      


Lys Ile Gln His Thr Lys Ile Phe Ile Asn Asn Glu Trp His Asp Ser 
            20                  25                  30          


Val Ser Ser Lys Lys Phe Pro Val Leu Asn Pro Ala Thr Glu Glu Val 
        35                  40                  45              


Ile Cys His Val Glu Glu Gly Asp Lys Ala Asp Val Asp Lys Ala Val 
    50                  55                  60                  


Lys Ala Ala Arg Gln Ala Phe Gln Ile Gly Ser Pro Trp Arg Thr Met 
65                  70                  75                  80  


Asp Ala Ser Glu Arg Gly Arg Leu Leu Asn Lys Leu Ala Asp Leu Met 
                85                  90                  95      


Glu Arg Asp Arg Leu Leu Leu Ala Thr Met Glu Ser Met Asn Ala Gly 
            100                 105                 110         


Lys Val Phe Ala His Ala Tyr Leu Leu Asp Val Glu Ile Ser Ile Lys 
        115                 120                 125             


Ala Leu Gln Tyr Phe Ala Gly Trp Ala Asp Lys Ile His Gly Gln Thr 
    130                 135                 140                 


Ile Pro Ser Asp Gly Asn Ile Phe Thr Tyr Thr Arg Arg Glu Pro Ile 
145                 150                 155                 160 


Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Gly Pro Leu Ile Ile Phe 
                165                 170                 175     


Thr Trp Lys Leu Gly Pro Ala Leu Ser Cys Gly Asn Thr Val Val Val 
            180                 185                 190         


Lys Pro Ala Glu Gln Thr Pro Leu Thr Ala Leu His Met Ala Ser Leu 
        195                 200                 205             


Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
    210                 215                 220                 


Tyr Gly Pro Thr Ala Gly Gly Ala Ile Ser Ser His Met Asp Ile Asp 
225                 230                 235                 240 


Lys Val Ser Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Lys Glu 
                245                 250                 255     


Ala Ala Gly Lys Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         


Lys Ser Pro Cys Ile Val Phe Ala Asp Ala Asp Leu Asp Ser Ala Val 
        275                 280                 285             


Glu Phe Ala His Gln Gly Val Phe Phe His Gln Gly Gln Ile Cys Val 
    290                 295                 300                 


Ala Ala Ser Arg Leu Phe Val Glu Glu Ser Ile Tyr Asp Glu Phe Val 
305                 310                 315                 320 


Arg Arg Ser Val Glu Arg Ala Lys Lys Tyr Ile Leu Gly Asn Pro Leu 
                325                 330                 335     


Asn Ser Gly Ile Asn Gln Gly Pro Gln Ile Asp Lys Glu Gln His Asn 
            340                 345                 350         


Lys Ile Leu Gly Leu Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu 
        355                 360                 365             


Glu Cys Gly Gly Gly Arg Trp Gly Asn Lys Gly Phe Phe Val Gln Pro 
    370                 375                 380                 


Thr Val Phe Ser Asn Val Thr Asp Glu Met Arg Ile Ala Lys Glu Glu 
385                 390                 395                 400 


Ile Phe Gly Pro Val Gln Gln Ile Met Lys Phe Lys Ser Met Asp Asp 
                405                 410                 415     


Val Ile Lys Arg Ala Asn Asn Thr Thr Tyr Gly Leu Ala Ala Gly Val 
            420                 425                 430         


Phe Thr Lys Asp Leu Asp Lys Ala Ile Thr Val Ser Ser Ala Leu Gln 
        435                 440                 445             


Ala Gly Met Val Trp Val Asn Cys Tyr Leu Ala Val Pro Val Gln Cys 
    450                 455                 460                 


Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu 
465                 470                 475                 480 


His Gly Leu Tyr Glu Tyr Thr Glu Leu Lys Thr Val Ala Met Gln Ile 
                485                 490                 495     


Ser Gln Lys Asn Ser 
            500     


<210>  65
<211>  2116
<212>  DNA
<213>  Homo sapiens - Aldehyde dehydrogenase 1 family, member A1


<220>
<221>  CDS
<222>  (54)..(1559)

<400>  65
atcagaacca aattgctgag ccagtcacct gtgttccagg agccgaatca gaa atg          56
                                                           Met            
                                                           1              

tca tcc tca ggc acg cca gac tta cct gtc cta ctc acc gat ttg aag        104
Ser Ser Ser Gly Thr Pro Asp Leu Pro Val Leu Leu Thr Asp Leu Lys           
            5                   10                  15                    

att caa tat act aag atc ttc ata aac aat gaa tgg cat gat tca gtg        152
Ile Gln Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp His Asp Ser Val           
        20                  25                  30                        

agt ggc aag aaa ttt cct gtc ttt aat cct gca act gag gag gag ctc        200
Ser Gly Lys Lys Phe Pro Val Phe Asn Pro Ala Thr Glu Glu Glu Leu           
    35                  40                  45                            

tgc cag gta gaa gaa gga gat aag gag gat gtt gac aag gca gtg aag        248
Cys Gln Val Glu Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val Lys           
50                  55                  60                  65            

gcc gca aga cag gct ttt cag att gga tcc ccg tgg cgt act atg gat        296
Ala Ala Arg Gln Ala Phe Gln Ile Gly Ser Pro Trp Arg Thr Met Asp           
                70                  75                  80                

gct tcc gag agg ggg cga cta tta tac aag ttg gct gat tta atc gaa        344
Ala Ser Glu Arg Gly Arg Leu Leu Tyr Lys Leu Ala Asp Leu Ile Glu           
            85                  90                  95                    

aga gat cgt ctg ctg ctg gcg aca atg gag tca atg aat ggt gga aaa        392
Arg Asp Arg Leu Leu Leu Ala Thr Met Glu Ser Met Asn Gly Gly Lys           
        100                 105                 110                       

ctc tat tcc aat gca tat ctg aat gat tta gca ggc tgc atc aaa aca        440
Leu Tyr Ser Asn Ala Tyr Leu Asn Asp Leu Ala Gly Cys Ile Lys Thr           
    115                 120                 125                           

ttg cgc tac tgt gca ggt tgg gct gac aag atc cag ggc cgt aca ata        488
Leu Arg Tyr Cys Ala Gly Trp Ala Asp Lys Ile Gln Gly Arg Thr Ile           
130                 135                 140                 145           

cca att gat gga aat ttt ttt aca tat aca aga cat gaa cct att ggt        536
Pro Ile Asp Gly Asn Phe Phe Thr Tyr Thr Arg His Glu Pro Ile Gly           
                150                 155                 160               

gta tgt ggc caa atc att cct tgg aat ttc ccg ttg gtt atg ctc att        584
Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Val Met Leu Ile           
            165                 170                 175                   

tgg aag ata ggg cct gca ctg agc tgt gga aac aca gtg gtt gtc aaa        632
Trp Lys Ile Gly Pro Ala Leu Ser Cys Gly Asn Thr Val Val Val Lys           
        180                 185                 190                       

cca gca gag caa act cct ctc act gct ctc cac gtg gca tct tta ata        680
Pro Ala Glu Gln Thr Pro Leu Thr Ala Leu His Val Ala Ser Leu Ile           
    195                 200                 205                           

aaa gag gca ggg ttt cct cct gga gta gtg aat att gtt cct ggt tat        728
Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly Tyr           
210                 215                 220                 225           

ggg cct aca gca ggg gca gcc att tct tct cac atg gat ata gac aaa        776
Gly Pro Thr Ala Gly Ala Ala Ile Ser Ser His Met Asp Ile Asp Lys           
                230                 235                 240               

gta gcc ttc aca gga tca aca gag gtt ggc aag ttg atc aaa gaa gct        824
Val Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Lys Glu Ala           
            245                 250                 255                   

gcc ggg aaa agc aat ctg aag agg gtg acc ctg gag ctt gga gga aag        872
Ala Gly Lys Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly Lys           
        260                 265                 270                       

agc cct tgc att gtg tta gct gat gcc gac ttg gac aat gct gtt gaa        920
Ser Pro Cys Ile Val Leu Ala Asp Ala Asp Leu Asp Asn Ala Val Glu           
    275                 280                 285                           

ttt gca cac cat ggg gta ttc tac cac cag ggc cag tgt tgt ata gcc        968
Phe Ala His His Gly Val Phe Tyr His Gln Gly Gln Cys Cys Ile Ala           
290                 295                 300                 305           

gca tcc agg att ttt gtg gaa gaa tca att tat gat gag ttt gtt cga       1016
Ala Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Asp Glu Phe Val Arg           
                310                 315                 320               

agg agt gtt gag cgg gct aag aag tat atc ctt gga aat cct ctg acc       1064
Arg Ser Val Glu Arg Ala Lys Lys Tyr Ile Leu Gly Asn Pro Leu Thr           
            325                 330                 335                   

cca gga gtc act caa ggc cct cag att gac aag gaa caa tat gat aaa       1112
Pro Gly Val Thr Gln Gly Pro Gln Ile Asp Lys Glu Gln Tyr Asp Lys           
        340                 345                 350                       

ata ctt gac ctc att gag agt ggg aag aaa gaa ggg gcc aaa ctg gaa       1160
Ile Leu Asp Leu Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu Glu           
    355                 360                 365                           

tgt gga gga ggc ccg tgg ggg aat aaa ggc tac ttt gtc cag ccc aca       1208
Cys Gly Gly Gly Pro Trp Gly Asn Lys Gly Tyr Phe Val Gln Pro Thr           
370                 375                 380                 385           

gtg ttc tct aat gtt aca gat gag atg cgc att gcc aaa gag gag att       1256
Val Phe Ser Asn Val Thr Asp Glu Met Arg Ile Ala Lys Glu Glu Ile           
                390                 395                 400               

ttt gga cca gtg cag caa atc atg aag ttt aaa tct tta gat gac gtg       1304
Phe Gly Pro Val Gln Gln Ile Met Lys Phe Lys Ser Leu Asp Asp Val           
            405                 410                 415                   

atc aaa aga gca aac aat act ttc tat ggc tta tca gca gga gtg ttt       1352
Ile Lys Arg Ala Asn Asn Thr Phe Tyr Gly Leu Ser Ala Gly Val Phe           
        420                 425                 430                       

acc aaa gac att gat aaa gcc ata aca atc tcc tct gct ctg cag gca       1400
Thr Lys Asp Ile Asp Lys Ala Ile Thr Ile Ser Ser Ala Leu Gln Ala           
    435                 440                 445                           

gga aca gtg tgg gtg aat tgc tat ggc gtg gta agt gcc cag tgc ccc       1448
Gly Thr Val Trp Val Asn Cys Tyr Gly Val Val Ser Ala Gln Cys Pro           
450                 455                 460                 465           

ttt ggt gga ttc aag atg tct gga aat gga aga gaa ctg gga gag tac       1496
Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu Tyr           
                470                 475                 480               

ggt ttc cat gaa tat aca gag gtc aaa aca gtc aca gtg aaa atc tct       1544
Gly Phe His Glu Tyr Thr Glu Val Lys Thr Val Thr Val Lys Ile Ser           
            485                 490                 495                   

cag aag aac tca taa agaaaataca agagtggaga gaagctcttc aatagctaag       1599
Gln Lys Asn Ser                                                           
        500                                                               

catctcctta cagtcactaa tatagtagat tttaaagaca aaatttttct tttcttgatt     1659

tttttaaaca taagctaaat catattagta ttaatactac ccatagaaaa cttgacatgt     1719

agcttcttct gaaagaatta tttgccttct gaaatgtgac ccccaagtcc tatcctaaat     1779

aaaaaaagac aaattcggat gtatgatctc tctagctttg tcatagttat gtgattttcc     1839

tttgtagcta cttttgcagg ataataattt tatagaaaag gaacagttgc atttagcttc     1899

tttcccttag tgactcttga agtacttaac atacacgtta actgcagagt aaattgctct     1959

gttcccagta gttataaagt ccttggactg ttttgaaaag tttcctagga tgtcatgtct     2019

gcttgtcaaa agaaataatc cctgtaatat ttagctgtaa actgaatata aagcttaata     2079

aaaacaacct tgcatgaaaa aaaaaaaaaa aaaaaaa                              2116


<210>  66
<211>  501
<212>  PRT
<213>  Homo sapiens - Aldehyde dehydrogenase 1 family, member A1

<400>  66

Met Ser Ser Ser Gly Thr Pro Asp Leu Pro Val Leu Leu Thr Asp Leu 
1               5                   10                  15      


Lys Ile Gln Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp His Asp Ser 
            20                  25                  30          


Val Ser Gly Lys Lys Phe Pro Val Phe Asn Pro Ala Thr Glu Glu Glu 
        35                  40                  45              


Leu Cys Gln Val Glu Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 
    50                  55                  60                  


Lys Ala Ala Arg Gln Ala Phe Gln Ile Gly Ser Pro Trp Arg Thr Met 
65                  70                  75                  80  


Asp Ala Ser Glu Arg Gly Arg Leu Leu Tyr Lys Leu Ala Asp Leu Ile 
                85                  90                  95      


Glu Arg Asp Arg Leu Leu Leu Ala Thr Met Glu Ser Met Asn Gly Gly 
            100                 105                 110         


Lys Leu Tyr Ser Asn Ala Tyr Leu Asn Asp Leu Ala Gly Cys Ile Lys 
        115                 120                 125             


Thr Leu Arg Tyr Cys Ala Gly Trp Ala Asp Lys Ile Gln Gly Arg Thr 
    130                 135                 140                 


Ile Pro Ile Asp Gly Asn Phe Phe Thr Tyr Thr Arg His Glu Pro Ile 
145                 150                 155                 160 


Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Val Met Leu 
                165                 170                 175     


Ile Trp Lys Ile Gly Pro Ala Leu Ser Cys Gly Asn Thr Val Val Val 
            180                 185                 190         


Lys Pro Ala Glu Gln Thr Pro Leu Thr Ala Leu His Val Ala Ser Leu 
        195                 200                 205             


Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
    210                 215                 220                 


Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ser Ser His Met Asp Ile Asp 
225                 230                 235                 240 


Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Lys Glu 
                245                 250                 255     


Ala Ala Gly Lys Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         


Lys Ser Pro Cys Ile Val Leu Ala Asp Ala Asp Leu Asp Asn Ala Val 
        275                 280                 285             


Glu Phe Ala His His Gly Val Phe Tyr His Gln Gly Gln Cys Cys Ile 
    290                 295                 300                 


Ala Ala Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Asp Glu Phe Val 
305                 310                 315                 320 


Arg Arg Ser Val Glu Arg Ala Lys Lys Tyr Ile Leu Gly Asn Pro Leu 
                325                 330                 335     


Thr Pro Gly Val Thr Gln Gly Pro Gln Ile Asp Lys Glu Gln Tyr Asp 
            340                 345                 350         


Lys Ile Leu Asp Leu Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu 
        355                 360                 365             


Glu Cys Gly Gly Gly Pro Trp Gly Asn Lys Gly Tyr Phe Val Gln Pro 
    370                 375                 380                 


Thr Val Phe Ser Asn Val Thr Asp Glu Met Arg Ile Ala Lys Glu Glu 
385                 390                 395                 400 


Ile Phe Gly Pro Val Gln Gln Ile Met Lys Phe Lys Ser Leu Asp Asp 
                405                 410                 415     


Val Ile Lys Arg Ala Asn Asn Thr Phe Tyr Gly Leu Ser Ala Gly Val 
            420                 425                 430         


Phe Thr Lys Asp Ile Asp Lys Ala Ile Thr Ile Ser Ser Ala Leu Gln 
        435                 440                 445             


Ala Gly Thr Val Trp Val Asn Cys Tyr Gly Val Val Ser Ala Gln Cys 
    450                 455                 460                 


Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu 
465                 470                 475                 480 


Tyr Gly Phe His Glu Tyr Thr Glu Val Lys Thr Val Thr Val Lys Ile 
                485                 490                 495     


Ser Gln Lys Asn Ser 
            500     


<210>  67
<211>  4751
<212>  DNA
<213>  Mus musculus - Thymoma viral proto-oncogene 3


<220>
<221>  CDS
<222>  (47)..(1486)

<400>  67
gcaaagcacc atttctccaa gttggggggc tcagagggga gccatc atg agc gat          55
                                                   Met Ser Asp            
                                                   1                      

gtt acc att gtg aaa gaa ggt tgg gtt cag aag agg gga gaa tat ata        103
Val Thr Ile Val Lys Glu Gly Trp Val Gln Lys Arg Gly Glu Tyr Ile           
    5                   10                  15                            

aaa aac tgg agg cca aga tac ttc ctt ttg aag aca gat ggc tca ttc        151
Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Thr Asp Gly Ser Phe           
20                  25                  30                  35            

ata ggc tat aag gag aaa cct caa gat gtg gac tta cct tat ccc ctc        199
Ile Gly Tyr Lys Glu Lys Pro Gln Asp Val Asp Leu Pro Tyr Pro Leu           
                40                  45                  50                

aac aac ttc tca gtg gca aaa tgt cag tta atg aaa aca gaa cga cca        247
Asn Asn Phe Ser Val Ala Lys Cys Gln Leu Met Lys Thr Glu Arg Pro           
            55                  60                  65                    

aag cca aat aca ttt att atc aga tgt ctt cag tgg acc act gtt ata        295
Lys Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp Thr Thr Val Ile           
        70                  75                  80                        

gag aga aca ttt cat gta gat aca cca gag gaa aga gaa gag tgg acg        343
Glu Arg Thr Phe His Val Asp Thr Pro Glu Glu Arg Glu Glu Trp Thr           
    85                  90                  95                            

gaa gct atc caa gcc gta gcc gac cga ttg cag agg caa gag gag gag        391
Glu Ala Ile Gln Ala Val Ala Asp Arg Leu Gln Arg Gln Glu Glu Glu           
100                 105                 110                 115           

agg atg aat tgt agc cca gcc tca cag att gat aat ata gga gaa gaa        439
Arg Met Asn Cys Ser Pro Ala Ser Gln Ile Asp Asn Ile Gly Glu Glu           
                120                 125                 130               

gag atg gat gcg tct aca acc cat cat aaa aga aag acg atg aat gat        487
Glu Met Asp Ala Ser Thr Thr His His Lys Arg Lys Thr Met Asn Asp           
            135                 140                 145                   

ttt gac tat ttg aaa cta cta ggt aaa ggc act ttt ggg aaa gtt att        535
Phe Asp Tyr Leu Lys Leu Leu Gly Lys Gly Thr Phe Gly Lys Val Ile           
        150                 155                 160                       

ttg gtt cga gag aag gca agt gga aaa tac tat gct atg aag att ctg        583
Leu Val Arg Glu Lys Ala Ser Gly Lys Tyr Tyr Ala Met Lys Ile Leu           
    165                 170                 175                           

aag aaa gaa gtc att att gca aag gat gaa gtg gca cac act ctt act        631
Lys Lys Glu Val Ile Ile Ala Lys Asp Glu Val Ala His Thr Leu Thr           
180                 185                 190                 195           

gaa agc aga gta cta aag aac acc aga cat cca ttt tta aca tcc ttg        679
Glu Ser Arg Val Leu Lys Asn Thr Arg His Pro Phe Leu Thr Ser Leu           
                200                 205                 210               

aaa tat tcc ttc cag aca aaa gac cgt ttg tgt ttt gtg atg gaa tat        727
Lys Tyr Ser Phe Gln Thr Lys Asp Arg Leu Cys Phe Val Met Glu Tyr           
            215                 220                 225                   

gtt aat ggc gga gag ctg ttt ttc cat ttg tcg aga gag cga gtg ttc        775
Val Asn Gly Gly Glu Leu Phe Phe His Leu Ser Arg Glu Arg Val Phe           
        230                 235                 240                       

tct gag gac cgc aca cgt ttc tat ggt gca gaa att gtc tct gct ttg        823
Ser Glu Asp Arg Thr Arg Phe Tyr Gly Ala Glu Ile Val Ser Ala Leu           
    245                 250                 255                           

gac tat cta cat tct gga aag att gtg tac cgt gat ctc aag ttg gag        871
Asp Tyr Leu His Ser Gly Lys Ile Val Tyr Arg Asp Leu Lys Leu Glu           
260                 265                 270                 275           

aat ttg atg cta gat aag gat ggc cat ata aaa att acg gat ttt ggg        919
Asn Leu Met Leu Asp Lys Asp Gly His Ile Lys Ile Thr Asp Phe Gly           
                280                 285                 290               

ctt tgc aaa gaa ggg atc aca gat gca gct acc atg aag aca ttc tgt        967
Leu Cys Lys Glu Gly Ile Thr Asp Ala Ala Thr Met Lys Thr Phe Cys           
            295                 300                 305                   

ggc aca cca gag tac ctg gca cca gag gta tta gaa gat aat gac tat       1015
Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp Asn Asp Tyr           
        310                 315                 320                       

ggc cga gcc gtg gac tgg tgg ggc tta ggt gtt gtc atg tat gaa atg       1063
Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met Tyr Glu Met           
    325                 330                 335                           

atg tgt gga agg ttg cct ttc tac aac cag gat cat gag aaa ctc ttt       1111
Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu Lys Leu Phe           
340                 345                 350                 355           

gaa tta ata cta atg gaa gac att aaa ttc ccc cga aca ctc tct tca       1159
Glu Leu Ile Leu Met Glu Asp Ile Lys Phe Pro Arg Thr Leu Ser Ser           
                360                 365                 370               

gat gca aaa tca ttg ctt tca ggg ctc ttg ata aag gat cca aat aaa       1207
Asp Ala Lys Ser Leu Leu Ser Gly Leu Leu Ile Lys Asp Pro Asn Lys           
            375                 380                 385                   

cgc ctt ggt gga ggg cca gat gat gca aaa gaa atc atg agg cat agt       1255
Arg Leu Gly Gly Gly Pro Asp Asp Ala Lys Glu Ile Met Arg His Ser           
        390                 395                 400                       

ttt ttt tct gga gta aac tgg caa gat gta tat gac aaa aag ctt gta       1303
Phe Phe Ser Gly Val Asn Trp Gln Asp Val Tyr Asp Lys Lys Leu Val           
    405                 410                 415                           

cct cct ttt aag cct caa gta aca tct gaa aca gac acc cga tat ttt       1351
Pro Pro Phe Lys Pro Gln Val Thr Ser Glu Thr Asp Thr Arg Tyr Phe           
420                 425                 430                 435           

gat gaa gaa ttt aca gct cag act att aca ata aca cca cct gaa aag       1399
Asp Glu Glu Phe Thr Ala Gln Thr Ile Thr Ile Thr Pro Pro Glu Lys           
                440                 445                 450               

tat gac gac gac ggc atg gac ggc atg gac agc gag cgg cgg cca cac       1447
Tyr Asp Asp Asp Gly Met Asp Gly Met Asp Ser Glu Arg Arg Pro His           
            455                 460                 465                   

ttc cct cag ttc tcc tac tct gca agc gga cgg gaa taa gttcctttca        1496
Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Arg Glu                           
        470                 475                                           

gtctgtttct acactgtcat cttagacttt gcctgagact gattcctgga catctctacc     1556

agtcctcgct cttacagtta gcaggggcac cttctgacat ccctgaccag ccaagggtct     1616

tcaccctcac cacctttcac tcacatgaaa ccatatacac agacactcca gttttgtttt     1676

tgcatgaaat tgtatctcag tctaaggtct catgctgttg ctgctactgt cttactatta     1736

tagcaacctt cagaagtaat ttcacaatct ttgggagtca tgagcccatt gttcatttgt     1796

gcatcaagtg tcatcttttg gtttttggtt ttccctagca gtgaaggcta aatgagatac     1856

actgattcta ggtacattgt taactttcta ggagataaat caagaactaa ttagactaag     1916

aagatttagt ttatatttct gaacaagcaa ttgttgaagg gtggtggtgt gtgtatgtaa     1976

gagtttagca gtgtatgtct gaccagcaca tgaagtgtgt atcactgaca tttggctgga     2036

aaatcttagg aaacattgag aggactgaag ggccaatgag atacacattt tttttttttt     2096

aaatcctgct ggctattgtg gaggaagccc agtgccaccc atggatgccc aggtttcaag     2156

ggcaaatgga cattgttcaa ccaagtactg acggtgcaga gtcccctaga gagtcttagg     2216

atctactttg taccagagag tattttcccc tgggcttggc aacctttttc ccttctttat     2276

atttatcacc tctgatggct gaagaatgta gacagtataa tgatcctgct gtcgccaaaa     2336

tctatacacc aaggtgaaca ggtgtttgcc ttaccagttt tggagttttt actttcagtt     2396

ataggtaaat tagctttttc tcagatgtta aaaccttgaa tgtcctttat ggttttgttt     2456

atattacagt agtatttatt ttttagtggt aagaattgtg ttgtcatgtt agcaagcgca     2516

gctccaattc acagatcatt gcctgcgttt tcttttgacc catgtgcaag gaatgtacac     2576

acccattaga atcatgcact ttttctccta tgttaaaaac aatggtaagg ctctgggact     2636

gtatctgttg gttagaatct ggctagaatc tctgggagaa gagatgctgt gatttaaccc     2696

cttggagctg aaatgagagc atccccaact acccagtgcc aagggatgga tgtgagagga     2756

tagtctggca gaaagtaatg gagaaagctg agacccaaat gatgatgaga aatgaactct     2816

actcggcaaa atgaacacat cacaagtatt cacacagtag gaagtaaagg ataagaagct     2876

gatgtgttta ttcttatcaa ggtacattca ttactgaatc aagccatcag ggaaaacaac     2936

aaaacaaaac acctctagct tttatttttc tgtacatatt catgtctccc aacccaaaca     2996

tttctcactg agaggggaca tgtatgcaaa cctcatcttt ctccttcatt aatgatgatc     3056

ttcagattaa ccctttggtg ctaggagctg acactttcca aagcagacta tgacgtccaa     3116

ggatcaaagc ctctcttgca gcaagcaaga gcaactgctg ctccaaggcg tgatcatgga     3176

agtggaagac cacagtgtga cacagtggta ctgcattgtc tttttcagta ggaagtcatg     3236

ttctcatgca agtgtcttgg cctctaggct cagacttaga gaagcagagc cgctgctggc     3296

agtggctggc cgctgggact gctggggtgt aaagggcatt ttcctaaggc agctaagaca     3356

gactcagaca tagatttttg tcctaatttt tcatgtttct acctgggtga gtttaccctc     3416

agtgggaagt aggaagttaa acaggtgtat tcttacatct gctgtcttct gttttcctac     3476

atagaagtat gttgaatgtt gcacattgac aaggaagtag attagatggt aagtcctttt     3536

aagttaccct gcatccattc tgtaagaaag gaggaggaga ggaagaaaag caagctgagc     3596

ctggccgatg ttcagaacat ttactccctc agagggagca gacactgtac actaagcaca     3656

cagcttcttt tgttttgtct ctccttccaa gtcttaaggt aatttcatga ccttggccaa     3716

ggatactttg tgaagattaa tgaggggaca ttgacaatgc ctcaggctgg ccactcctca     3776

cactggccct tggtccccag ccattcaagg ggttactcat cccatccctg actacctgag     3836

tgtcactaca ggtgggttct tggctttgag ttcaagaatt ctttccttac accctccacc     3896

agatgtcagt ggaaaggcag aagtagaacc gaggtgtggg aggagattct aaaagcttgt     3956

gttgcccagg cctctagctt agggttctgg caattgagac ggcctgaaac ctgacagcat     4016

catgtccggg cagctctggc tttgtgagtc cagctcctac caactccacc ttgacctctt     4076

gtctccatgc agggctgtct gggaggaaac tggccacttc tgctcagact gctgccagcg     4136

ctctcacagc tttgctctct acactaatga catagattat tccagtattg ttcccatttc     4196

ccacctgacc tccagcttct cggagctgac ttcttgcagg ggccacatgc ttctttccct     4256

cactaactgc agggtctcca ccacacctca gtgtacacac tttgctgcta ccgtctgtac     4316

tgtctacatc acggttccct tagcttgctc ctggtagtgc attacaggca agcatgaaat     4376

gtaaagtatt tatttaaata aaaaggaaac ctctgaattg gtcatcgagt cacctccctg     4436

tagatttgta gtctgtgaca tatttcgact ttctagtcct gctagatcca tataagatct     4496

ggtcatctgg ttaagggttt gaagcagaca tagctatgaa cccggatggt atcatcactg     4556

tcacggctgg ccacactaca gatgtttatg tccttacgtt tatgacccac agggtgtgaa     4616

gtaacttcca agaacctgat tttgtacact gtccactctc agcatctcac actctctgat     4676

agggacacac attacttcct tcgtacagac agcttaaata aagccctatg tcaatctgca     4736

aaaaaaaaaa aaaaa                                                      4751


<210>  68
<211>  479
<212>  PRT
<213>  Mus musculus - Thymoma viral proto-oncogene 3

<400>  68

Met Ser Asp Val Thr Ile Val Lys Glu Gly Trp Val Gln Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Thr Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Lys Pro Gln Asp Val Asp Leu Pro 
        35                  40                  45              


Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys Cys Gln Leu Met Lys Thr 
    50                  55                  60                  


Glu Arg Pro Lys Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp Thr 
65                  70                  75                  80  


Thr Val Ile Glu Arg Thr Phe His Val Asp Thr Pro Glu Glu Arg Glu 
                85                  90                  95      


Glu Trp Thr Glu Ala Ile Gln Ala Val Ala Asp Arg Leu Gln Arg Gln 
            100                 105                 110         


Glu Glu Glu Arg Met Asn Cys Ser Pro Ala Ser Gln Ile Asp Asn Ile 
        115                 120                 125             


Gly Glu Glu Glu Met Asp Ala Ser Thr Thr His His Lys Arg Lys Thr 
    130                 135                 140                 


Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys Gly Thr Phe Gly 
145                 150                 155                 160 


Lys Val Ile Leu Val Arg Glu Lys Ala Ser Gly Lys Tyr Tyr Ala Met 
                165                 170                 175     


Lys Ile Leu Lys Lys Glu Val Ile Ile Ala Lys Asp Glu Val Ala His 
            180                 185                 190         


Thr Leu Thr Glu Ser Arg Val Leu Lys Asn Thr Arg His Pro Phe Leu 
        195                 200                 205             


Thr Ser Leu Lys Tyr Ser Phe Gln Thr Lys Asp Arg Leu Cys Phe Val 
    210                 215                 220                 


Met Glu Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Ser Arg Glu 
225                 230                 235                 240 


Arg Val Phe Ser Glu Asp Arg Thr Arg Phe Tyr Gly Ala Glu Ile Val 
                245                 250                 255     


Ser Ala Leu Asp Tyr Leu His Ser Gly Lys Ile Val Tyr Arg Asp Leu 
            260                 265                 270         


Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile Lys Ile Thr 
        275                 280                 285             


Asp Phe Gly Leu Cys Lys Glu Gly Ile Thr Asp Ala Ala Thr Met Lys 
    290                 295                 300                 


Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp 
305                 310                 315                 320 


Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met 
                325                 330                 335     


Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu 
            340                 345                 350         


Lys Leu Phe Glu Leu Ile Leu Met Glu Asp Ile Lys Phe Pro Arg Thr 
        355                 360                 365             


Leu Ser Ser Asp Ala Lys Ser Leu Leu Ser Gly Leu Leu Ile Lys Asp 
    370                 375                 380                 


Pro Asn Lys Arg Leu Gly Gly Gly Pro Asp Asp Ala Lys Glu Ile Met 
385                 390                 395                 400 


Arg His Ser Phe Phe Ser Gly Val Asn Trp Gln Asp Val Tyr Asp Lys 
                405                 410                 415     


Lys Leu Val Pro Pro Phe Lys Pro Gln Val Thr Ser Glu Thr Asp Thr 
            420                 425                 430         


Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Thr Ile Thr Ile Thr Pro 
        435                 440                 445             


Pro Glu Lys Tyr Asp Asp Asp Gly Met Asp Gly Met Asp Ser Glu Arg 
    450                 455                 460                 


Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Arg Glu 
465                 470                 475                 


<210>  69
<211>  1623
<212>  DNA
<213>  Homo sapiens - v-akt murine thymoma viral oncogene homolog 3


<220>
<221>  CDS
<222>  (84)..(1481)

<400>  69
cagcagcagc agagaatcca aaccctaaag ctgatatcac aaagtaccat ttctccaagt       60

tgggggctca gaggggagtc atc atg agc gat gtt acc att gtg aaa gaa ggt      113
                          Met Ser Asp Val Thr Ile Val Lys Glu Gly         
                          1               5                   10          

tgg gtt cag aag agg gga gaa tat ata aaa aac tgg agg cca aga tac        161
Trp Val Gln Lys Arg Gly Glu Tyr Ile Lys Asn Trp Arg Pro Arg Tyr           
                15                  20                  25                

ttc ctt ttg aag aca gat ggc tca ttc ata gga tat aaa gag aaa cct        209
Phe Leu Leu Lys Thr Asp Gly Ser Phe Ile Gly Tyr Lys Glu Lys Pro           
            30                  35                  40                    

caa gat gtg gat tta cct tat ccc ctc aac aac ttt tca gtg gca aaa        257
Gln Asp Val Asp Leu Pro Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys           
        45                  50                  55                        

tgc cag tta atg aaa aca gaa cga cca aag cca aac aca ttt ata atc        305
Cys Gln Leu Met Lys Thr Glu Arg Pro Lys Pro Asn Thr Phe Ile Ile           
    60                  65                  70                            

aga tgt ctc cag tgg act act gtt ata gag aga aca ttt cat gta gat        353
Arg Cys Leu Gln Trp Thr Thr Val Ile Glu Arg Thr Phe His Val Asp           
75                  80                  85                  90            

act cca gag gaa agg gaa gaa tgg aca gaa gct atc cag gct gta gca        401
Thr Pro Glu Glu Arg Glu Glu Trp Thr Glu Ala Ile Gln Ala Val Ala           
                95                  100                 105               

gac aga ctg cag agg caa gaa gag gag aga atg aat tgt agt cca act        449
Asp Arg Leu Gln Arg Gln Glu Glu Glu Arg Met Asn Cys Ser Pro Thr           
            110                 115                 120                   

tca caa att gat aat ata gga gag gaa gag atg gat gcc tct aca acc        497
Ser Gln Ile Asp Asn Ile Gly Glu Glu Glu Met Asp Ala Ser Thr Thr           
        125                 130                 135                       

cat cat aaa aga aag aca atg aat gat ttt gac tat ttg aaa cta cta        545
His His Lys Arg Lys Thr Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu           
    140                 145                 150                           

ggt aaa ggc act ttt ggg aaa gtt att ttg gtt cga gag aag gca agt        593
Gly Lys Gly Thr Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Ser           
155                 160                 165                 170           

gga aaa tac tat gct atg aag att ctg aag aaa gaa gtc att att gca        641
Gly Lys Tyr Tyr Ala Met Lys Ile Leu Lys Lys Glu Val Ile Ile Ala           
                175                 180                 185               

aag gat gaa gtg gca cac act cta act gaa agc aga gta tta aag aac        689
Lys Asp Glu Val Ala His Thr Leu Thr Glu Ser Arg Val Leu Lys Asn           
            190                 195                 200                   

act aga cat ccc ttt tta aca tcc ttg aaa tat tcc ttc cag aca aaa        737
Thr Arg His Pro Phe Leu Thr Ser Leu Lys Tyr Ser Phe Gln Thr Lys           
        205                 210                 215                       

gac cgt ttg tgt ttt gtg atg gaa tat gtt aat ggg ggc gag ctg ttt        785
Asp Arg Leu Cys Phe Val Met Glu Tyr Val Asn Gly Gly Glu Leu Phe           
    220                 225                 230                           

ttc cat ttg tcg aga gag cgg gtg ttc tct gag gac cgc aca cgt ttc        833
Phe His Leu Ser Arg Glu Arg Val Phe Ser Glu Asp Arg Thr Arg Phe           
235                 240                 245                 250           

tat ggt gca gaa att gtc tct gcc ttg gac tat cta cat tcc gga aag        881
Tyr Gly Ala Glu Ile Val Ser Ala Leu Asp Tyr Leu His Ser Gly Lys           
                255                 260                 265               

att gtg tac cgt gat ctc aag ttg gag aat cta atg cgg gac aaa gat        929
Ile Val Tyr Arg Asp Leu Lys Leu Glu Asn Leu Met Arg Asp Lys Asp           
            270                 275                 280                   

ggc cac ata aaa att aca gat ttt gga ctt tgc aaa gaa ggg atc aca        977
Gly His Ile Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Thr           
        285                 290                 295                       

gat gca gcc acc atg aag aca ttc tgt ggc act cca gaa tat ctg gca       1025
Asp Ala Ala Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala           
    300                 305                 310                           

cca gag gtg tta gaa gat aat gac tat ggc cga gca gta gac tgg tgg       1073
Pro Glu Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp           
315                 320                 325                 330           

ggc cta ggg gtt gtc atg tat gaa atg atg tgt ggg agg tta cct ttc       1121
Gly Leu Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe           
                335                 340                 345               

tac aac cag gac cat gag aaa ctt ttt gaa tta ata tta atg gaa gac       1169
Tyr Asn Gln Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Asp           
            350                 355                 360                   

att aaa ttt cct cga aca ctc tct tca gat gca aaa tca ttg ctt tca       1217
Ile Lys Phe Pro Arg Thr Leu Ser Ser Asp Ala Lys Ser Leu Leu Ser           
        365                 370                 375                       

ggg ctc ttg ata aag gat cca aat aaa cgc ctt ggt gga gga cca gat       1265
Gly Leu Leu Ile Lys Asp Pro Asn Lys Arg Leu Gly Gly Gly Pro Asp           
    380                 385                 390                           

gat gca aaa gaa att atg aga cac agt ttc ttc tct gga gta aac tgg       1313
Asp Ala Lys Glu Ile Met Arg His Ser Phe Phe Ser Gly Val Asn Trp           
395                 400                 405                 410           

caa gat gta tat gat aaa aag ctt gta cct cct ttt aaa cct caa gta       1361
Gln Asp Val Tyr Asp Lys Lys Leu Val Pro Pro Phe Lys Pro Gln Val           
                415                 420                 425               

aca tct gag aca gat act aga tat ttt gat gaa gaa ttt aca gct cag       1409
Thr Ser Glu Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln           
            430                 435                 440                   

act att aca ata aca cca cct gaa aaa tgt cag caa tca gat tgt ggc       1457
Thr Ile Thr Ile Thr Pro Pro Glu Lys Cys Gln Gln Ser Asp Cys Gly           
        445                 450                 455                       

atg ctg ggt aac tgg aaa aaa taa taaaaatcgg cttcctacag ccagcagcac      1511
Met Leu Gly Asn Trp Lys Lys                                               
    460                 465                                               

agtcacccat ggaactgttg gctttggatt aaatgtggaa ttgaacgact acccagaagt     1571

gttctggaaa gaagcgagat gtgtggcctg cctcaccgtc ctcacccatc aa             1623


<210>  70
<211>  465
<212>  PRT
<213>  Homo sapiens - v-akt murine thymoma viral oncogene homolog 3

<400>  70

Met Ser Asp Val Thr Ile Val Lys Glu Gly Trp Val Gln Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Thr Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Lys Pro Gln Asp Val Asp Leu Pro 
        35                  40                  45              


Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys Cys Gln Leu Met Lys Thr 
    50                  55                  60                  


Glu Arg Pro Lys Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp Thr 
65                  70                  75                  80  


Thr Val Ile Glu Arg Thr Phe His Val Asp Thr Pro Glu Glu Arg Glu 
                85                  90                  95      


Glu Trp Thr Glu Ala Ile Gln Ala Val Ala Asp Arg Leu Gln Arg Gln 
            100                 105                 110         


Glu Glu Glu Arg Met Asn Cys Ser Pro Thr Ser Gln Ile Asp Asn Ile 
        115                 120                 125             


Gly Glu Glu Glu Met Asp Ala Ser Thr Thr His His Lys Arg Lys Thr 
    130                 135                 140                 


Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys Gly Thr Phe Gly 
145                 150                 155                 160 


Lys Val Ile Leu Val Arg Glu Lys Ala Ser Gly Lys Tyr Tyr Ala Met 
                165                 170                 175     


Lys Ile Leu Lys Lys Glu Val Ile Ile Ala Lys Asp Glu Val Ala His 
            180                 185                 190         


Thr Leu Thr Glu Ser Arg Val Leu Lys Asn Thr Arg His Pro Phe Leu 
        195                 200                 205             


Thr Ser Leu Lys Tyr Ser Phe Gln Thr Lys Asp Arg Leu Cys Phe Val 
    210                 215                 220                 


Met Glu Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Ser Arg Glu 
225                 230                 235                 240 


Arg Val Phe Ser Glu Asp Arg Thr Arg Phe Tyr Gly Ala Glu Ile Val 
                245                 250                 255     


Ser Ala Leu Asp Tyr Leu His Ser Gly Lys Ile Val Tyr Arg Asp Leu 
            260                 265                 270         


Lys Leu Glu Asn Leu Met Arg Asp Lys Asp Gly His Ile Lys Ile Thr 
        275                 280                 285             


Asp Phe Gly Leu Cys Lys Glu Gly Ile Thr Asp Ala Ala Thr Met Lys 
    290                 295                 300                 


Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp 
305                 310                 315                 320 


Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met 
                325                 330                 335     


Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu 
            340                 345                 350         


Lys Leu Phe Glu Leu Ile Leu Met Glu Asp Ile Lys Phe Pro Arg Thr 
        355                 360                 365             


Leu Ser Ser Asp Ala Lys Ser Leu Leu Ser Gly Leu Leu Ile Lys Asp 
    370                 375                 380                 


Pro Asn Lys Arg Leu Gly Gly Gly Pro Asp Asp Ala Lys Glu Ile Met 
385                 390                 395                 400 


Arg His Ser Phe Phe Ser Gly Val Asn Trp Gln Asp Val Tyr Asp Lys 
                405                 410                 415     


Lys Leu Val Pro Pro Phe Lys Pro Gln Val Thr Ser Glu Thr Asp Thr 
            420                 425                 430         


Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Thr Ile Thr Ile Thr Pro 
        435                 440                 445             


Pro Glu Lys Cys Gln Gln Ser Asp Cys Gly Met Leu Gly Asn Trp Lys 
    450                 455                 460                 


Lys 
465 


<210>  71
<211>  1799
<212>  DNA
<213>  Mus musculus - 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130020G16 product

<400>  71
tatggaatag ggcatttcca gaggggaaac tgggaaagga gataaaattt caagtgtaaa       60

taaataaaat attcaataca aaaaaagtag tctggaccaa gagaacaaga gactgacaaa      120

gccaaagtat ctgtgttata acaataacaa tattgttaat tataacagtt atataaaaat      180

caggctaggg aaagggaaag cccagcccca ggttgggggc gggatgagaa gtgttgggag      240

gaacccccag taaggagtgg tgctgcccaa gctgggagga gctggccagc agtggcttcc      300

ataagcatgt cagccagcta ttggtttctg aaaggtagcc tctacaaacc tgagttgctg      360

agtctggtgt ggtagcaagc tctggttgtc atacacaaaa tgctcaaatg aaggccagct      420

gataaaaaga aaaacactaa gcctaatggt atatatctat cgtctgccac cttttaccca      480

aggaatacat gtcaagtcaa catgttagga gtttcagcaa tatttactaa tctttgctat      540

gagtccagtg tcttagttaa cgtgtagtgc tgctatcctg ttgtttactg cattttattc      600

ttgctttgtc tctcatcact gtaaatcata atcgataaag cgcatcacta tgacaagcgt      660

catgcttttc tggaggtcac tcttcctggg agtgcgtcaa tgtaaaatgt gtcttcctat      720

tttaaaactt tcgatgagtc tttggcatct acataacagc tcagtctcca gtttttcccc      780

cagtcttcca cttctgtcaa gaaatcacaa gtccaggtct tgcctccatt taataattgt      840

gctccactgg agagtttcaa gtattcaagt ctacagctca tatgtcttca taggcgtccc      900

taactgaaat taatggagaa gatgacaaat ttataaaact tcattttttg tcttctgaaa      960

atatgtattc atcaatcttt ttaaaactgt ctctgtgatt ttgtttatta ttcatctcac     1020

tgctcgcaaa acggacacaa aatgtcagag aaatatttgc tgtgttttcc aaaggggaat     1080

ttagagaggg agtaaagaat aagttgtggg gtagataata ccgattttaa atgctgttgc     1140

tagacaacag ctgctgatta tgggaagttt ctgaagttct ccatataagt tgtctcgtgt     1200

atgaagtgac caataacttt aaaaactttt ggatcgtaaa tctgtcaaga gacagattga     1260

actagagtat gtaaagtatt tgtagatctt aacatacaat gacctgtgta ctgaagttaa     1320

tgatgttaat tagctattgt taattacaat aacttctgta atctcagaag ctcacattgc     1380

acttgactca gccccgctgt caatcaatat tatgctggtg aatgaataac atgagttaat     1440

gattactgta agtagcacaa attccgtagt gccattttta taatatttac ccccgttgat     1500

ttccttatta ttatggctta tttcttcaga aattatcttt atctgtgcaa gagaattcac     1560

tccaactcag tcagccatat agttagtaga gctctgccag atctgtggag cagagagaaa     1620

atgaatgggc tggaaatgaa gttattagtg gagtggcctc atgccacggc agcttctctt     1680

ttgttaatat taaaaaaacg atttcttcac acagcatcca aaatagctac ttaacaatat     1740

aaagtggggc atgtttctcc attccataaa agttcccagt ggcttctttt cacacacag      1799


<210>  72
<211>  715
<212>  DNA
<213>  Mus musculus - IL-2


<220>
<221>  CDS
<222>  (47)..(556)

<400>  72
tcacccttgc taatcactcc tcacagtgac ctcaagtcct gcaggc atg tac agc          55
                                                   Met Tyr Ser            
                                                   1                      

atg cag ctc gca tcc tgt gtc aca ctg aca ctt gtg ctc ctt gtc aac        103
Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu Leu Val Asn           
    5                   10                  15                            

agc gca ccc act tca agc ccc act tca agc ccc act tca agc tct aca        151
Ser Ala Pro Thr Ser Ser Pro Thr Ser Ser Pro Thr Ser Ser Ser Thr           
20                  25                  30                  35            

gcg gaa gca cag cag cag cag cag cag cag cag cac ctg gag cag ctg        199
Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu           
                40                  45                  50                

ttg atg gac cta cag gag ctc ctg agc agg atg gag aat tac agg aac        247
Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn           
            55                  60                  65                    

ctg aaa ctc ccc agg atg ctc acc ttc aaa ttt tac ttg ccc aag cag        295
Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln           
        70                  75                  80                        

gcc aca gaa ttg aaa gat ctt cag tgc cta gaa gat gaa ctt gga cct        343
Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro           
    85                  90                  95                            

ctg cgg cat gtt ctg gat ttg act caa agc aaa agc ttt caa ttg gaa        391
Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu           
100                 105                 110                 115           

gat gct gag aat ttc atc agc aat atc aga gta act gtt gta aaa cta        439
Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu           
                120                 125                 130               

aag ggc tct gac aac aca ttt gag tgc caa ttc gat gat gag tca gca        487
Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala           
            135                 140                 145                   

act gtg gtg gac ttt ctg agg aga tgg ata gcc ttc tgt caa agc atc        535
Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile           
        150                 155                 160                       

atc tca aca agc cct caa taa ctatgtacct cctgcttaca acacataagg           586
Ile Ser Thr Ser Pro Gln                                                   
    165                                                                   

ctctctattt atttaaatat ttaactttaa tttatttttg gatgtattgt ttactatctt      646

ttgtaactac tagtcttcag atgataaata tggatcttta aagattcttt ttgtaagccc      706

caagggctc                                                              715


<210>  73
<211>  169
<212>  PRT
<213>  Mus musculus - IL-2

<400>  73

Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Pro Thr Ser Ser Pro Thr Ser 
            20                  25                  30          


Ser Ser Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln 
                165                 


<210>  74
<211>  822
<212>  DNA
<213>  Homo sapiens - IL-2


<220>
<221>  CDS
<222>  (56)..(517)

<400>  74
agttccctat cactctcttt aatcactact cacagtaacc tcaactcctg ccaca atg        58
                                                             Met          
                                                             1            

tac agg atg caa ctc ctg tct tgc att gca cta agt ctt gca ctt gtc        106
Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val           
            5                   10                  15                    

aca aac agt gca cct act tca agt tct aca aag aaa aca cag cta caa        154
Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln           
        20                  25                  30                        

ctg gag cat tta ctg ctg gat tta cag atg att ttg aat gga att aat        202
Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn           
    35                  40                  45                            

aat tac aag aat ccc aaa ctc acc agg atg ctc aca ttt aag ttt tac        250
Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr           
50                  55                  60                  65            

atg ccc aag aag gcc aca gaa ctg aaa cat ctt cag tgt cta gaa gaa        298
Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu           
                70                  75                  80                

gaa ctc aaa cct ctg gag gaa gtg cta aat tta gct caa agc aaa aac        346
Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn           
            85                  90                  95                    

ttt cac tta aga ccc agg gac tta atc agc aat atc aac gta ata gtt        394
Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val           
        100                 105                 110                       

ctg gaa cta aag gga tct gaa aca aca ttc atg tgt gaa tat gct gat        442
Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp           
    115                 120                 125                           

gag aca gca acc att gta gaa ttt ctg aac aga tgg att acc ttt tgt        490
Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys           
130                 135                 140                 145           

caa agc atc atc tca aca ctg act tga taattaagtg cttcccactt              537
Gln Ser Ile Ile Ser Thr Leu Thr                                           
                150                                                       

aaaacatatc aggccttcta tttatttaaa tatttaaatt ttatatttat tgttgaatgt      597

atggtttgct acctattgta actattattc ttaatcttaa aactataaat atggatcttt      657

tatgattctt tttgtaagcc ctaggggctc taaaatggtt tcacttattt atcccaaaat      717

atttattatt atgttgaatg ttaaatatag tatctatgta gattggttag taaaactatt      777

taataaattt gataaatata aaaaaaaaaa aaaaaaaaaa aaaaa                      822


<210>  75
<211>  153
<212>  PRT
<213>  Homo sapiens - IL-2

<400>  75

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  76
<211>  916
<212>  DNA
<213>  Mus musculus - GM-CSF


<220>
<221>  CDS
<222>  (138)..(599)

<400>  76
gagctcagca agcgctctcc cccaattccc ttagccaaag tggacgccac cgaacagaca       60

gacctaggct aagaggtttg atgtctctgg ctacccgact ttgaaaattt tccgcaaagg      120

aaggcctttt gactaca atg gcc cac gag aga aag gct aag gtc ctg agg         170
                   Met Ala His Glu Arg Lys Ala Lys Val Leu Arg            
                   1               5                   10                 

agg atg tgg ctg cag aat tta ctt ttc ctg ggc att gtg gtc tac agc        218
Arg Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser           
            15                  20                  25                    

ctc tca gca ccc acc cgc tca ccc atc act gtc acc cgg cct tgg aag        266
Leu Ser Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys           
        30                  35                  40                        

cat gta gag gcc atc aaa gaa gcc ctg aac ctc ctg gat gac atg cct        314
His Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro           
    45                  50                  55                            

gtc aca ttg aat gaa gag gta gaa gtc gtc tct aac gag ttc tcc ttc        362
Val Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe           
60                  65                  70                  75            

aag aag cta aca tgt gtg cag acc cgc ctg aag ata ttc gag cag ggt        410
Lys Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly           
                80                  85                  90                

cta cgg ggc aat ttc acc aaa ctc aag ggc gcc ttg aac atg aca gcc        458
Leu Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala           
            95                  100                 105                   

agc tac tac cag aca tac tgc ccc cca act ccg gaa acg gac tgt gaa        506
Ser Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu           
        110                 115                 120                       

aca caa gtt acc acc tat gcg gat ttc ata gac agc ctt aaa acc ttt        554
Thr Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe           
    125                 130                 135                           

ctg act gat atc ccc ttt gaa tgc aaa aaa cca gtc caa aaa tga            599
Leu Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Val Gln Lys                   
140                 145                 150                               

ggaagcccag gccagctctg aatccagctt ctcagactgc tgcttttgtg cctgcgtaat      659

gagccaggaa ctcggaattt ctgccttaaa gggaccaaga gatgtggcac agccacagtt      719

ggagggcagt atagccctct gaaaacgctg actcagcttg gacagcggca agacaaacga      779

gagatatttt ctactgatag ggaccattat atttatttat atatttatat tttttaaata      839

tttatttatt tatttattta attttgcaac tctatttatt gagaatgtct taccagataa      899

taaattatta aaacttt                                                     916


<210>  77
<211>  153
<212>  PRT
<213>  Mus musculus - GM-CSF

<400>  77

Met Ala His Glu Arg Lys Ala Lys Val Leu Arg Arg Met Trp Leu Gln 
1               5                   10                  15      


Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu Ser Ala Pro Thr 
            20                  25                  30          


Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val Glu Ala Ile 
        35                  40                  45              


Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr Leu Asn Glu 
    50                  55                  60                  


Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys Leu Thr Cys 
65                  70                  75                  80  


Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg Gly Asn Phe 
                85                  90                  95      


Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr Tyr Gln Thr 
            100                 105                 110         


Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln Val Thr Thr 
        115                 120                 125             


Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr Asp Ile Pro 
    130                 135                 140                 


Phe Glu Cys Lys Lys Pro Val Gln Lys 
145                 150             


<210>  78
<211>  789
<212>  DNA
<213>  Homo sapiens - GM-CSF


<220>
<221>  CDS
<222>  (33)..(467)

<400>  78
acacagagag aaaggctaaa gttctctgga gg atg tgg ctg cag agc ctg ctg         53
                                    Met Trp Leu Gln Ser Leu Leu           
                                    1               5                     

ctc ttg ggc act gtg gcc tgc agc atc tct gca ccc gcc cgc tcg ccc        101
Leu Leu Gly Thr Val Ala Cys Ser Ile Ser Ala Pro Ala Arg Ser Pro           
        10                  15                  20                        

agc ccc agc acg cag ccc tgg gag cat gtg aat gcc atc cag gag gcc        149
Ser Pro Ser Thr Gln Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala           
    25                  30                  35                            

cgg cgt ctc ctg aac ctg agt aga gac act gct gct gag atg aat gaa        197
Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu           
40                  45                  50                  55            

aca gta gaa gtc atc tca gaa atg ttt gac ctc cag gag ccg acc tgc        245
Thr Val Glu Val Ile Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys           
                60                  65                  70                

cta cag acc cgc ctg gag ctg tac aag cag ggc ctg cgg ggc agc ctc        293
Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu           
            75                  80                  85                    

acc aag ctc aag ggc ccc ttg acc atg atg gcc agc cac tac aag cag        341
Thr Lys Leu Lys Gly Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln           
        90                  95                  100                       

cac tgc cct cca acc ccg gaa act tcc tgt gca acc cag att atc acc        389
His Cys Pro Pro Thr Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr           
    105                 110                 115                           

ttt gaa agt ttc aaa gag aac ctg aag gac ttt ctg ctt gtc atc ccc        437
Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro           
120                 125                 130                 135           

ttt gac tgc tgg gag cca gtc cag gag tga gaccggccag atgaggctgg          487
Phe Asp Cys Trp Glu Pro Val Gln Glu                                       
                140                                                       

ccaagccggg gagctgctct ctcatgaaac aagagctaga aactcaggat ggtcatcttg      547

gagggaccaa ggggtgggcc acagccatgg tgggagtggc ctggacctgc cctgggcaca      607

ctgaccctga tacaggcatg gcagaagaat gggaatattt tatactgaca gaaatcagta      667

atatttatat atttatattt ttaaaatatt tatttattta tttatttaag ttcatattcc      727

atatttattc aagatgtttt accgtaataa ttattattaa aaatagcttc taaaaaaaaa      787

aa                                                                     789


<210>  79
<211>  144
<212>  PRT
<213>  Homo sapiens - GM-CSF

<400>  79

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  80
<211>  1171
<212>  DNA
<213>  Mus musculus - IL-17A


<220>
<221>  CDS
<222>  (58)..(534)

<400>  80
atccacctca cacgaggcac aagtgcaccc agcaccagct gatcaggacg cgcaaac          57

atg agt cca ggg aga gct tca tct gtg tct ctg atg ctg ttg ctg ctg        105
Met Ser Pro Gly Arg Ala Ser Ser Val Ser Leu Met Leu Leu Leu Leu           
1               5                   10                  15                

ctg agc ctg gcg gct aca gtg aag gca gca gcg atc atc cct caa agc        153
Leu Ser Leu Ala Ala Thr Val Lys Ala Ala Ala Ile Ile Pro Gln Ser           
            20                  25                  30                    

tca gcg tgt cca aac act gag gcc aag gac ttc ctc cag aat gtg aag        201
Ser Ala Cys Pro Asn Thr Glu Ala Lys Asp Phe Leu Gln Asn Val Lys           
        35                  40                  45                        

gtc aac ctc aaa gtc ttt aac tcc ctt ggc gca aaa gtg agc tcc aga        249
Val Asn Leu Lys Val Phe Asn Ser Leu Gly Ala Lys Val Ser Ser Arg           
    50                  55                  60                            

agg ccc tca gac tac ctc aac cgt tcc acg tca ccc tgg act ctc cac        297
Arg Pro Ser Asp Tyr Leu Asn Arg Ser Thr Ser Pro Trp Thr Leu His           
65                  70                  75                  80            

cgc aat gaa gac cct gat aga tat ccc tct gtg atc tgg gaa gct cag        345
Arg Asn Glu Asp Pro Asp Arg Tyr Pro Ser Val Ile Trp Glu Ala Gln           
                85                  90                  95                

tgc cgc cac cag cgc tgt gtc aat gcg gag gga aag ctg gac cac cac        393
Cys Arg His Gln Arg Cys Val Asn Ala Glu Gly Lys Leu Asp His His           
            100                 105                 110                   

atg aat tct gtt ctc atc cag caa gag atc ctg gtc ctg aag agg gag        441
Met Asn Ser Val Leu Ile Gln Gln Glu Ile Leu Val Leu Lys Arg Glu           
        115                 120                 125                       

cct gag agc tgc ccc ttc act ttc agg gtc gag aag atg ctg gtg ggt        489
Pro Glu Ser Cys Pro Phe Thr Phe Arg Val Glu Lys Met Leu Val Gly           
    130                 135                 140                           

gtg ggc tgc acc tgc gtg gcc tcg att gtc cgc cag gca gcc taa            534
Val Gly Cys Thr Cys Val Ala Ser Ile Val Arg Gln Ala Ala                   
145                 150                 155                               

acagagaccc gcggctgacc cctaagaaac ccccacgttt ctcagcaaac ttacttgcat      594

ttttaaaaca gttcgtgcta ttgattttca gcaaggaatg tggattcaga ggcagattca      654

gaattgtctg ccctccacaa tgaaaagaag gtgtaaaggg gtcccaaact gcttcgtgtt      714

tgtttttctg tggactttaa attatttgtg tatttacaat atcccaagat agctttgaag      774

cgtaacttat tttaatgaag tatctacatt attattatgt ttctttctga agaagacaaa      834

attcaagact cagaaatttt attatttaaa aggtaaagcc tatatttata tgagctattt      894

atgaatctat ttatttttct tcagtatttg aagtattaag aacatgattt tcagatctac      954

ctagggaagt cctaagtaag attaaatatt aatggaaatt tcagctttac tatttgttta     1014

tttaaggttc tctcctctga atggggtgaa aaccaaactt agttttatgt ttaataactt     1074

tttaaattat tgaagattca aaaaattgga taatttagct ccctactctg ttttaaaaaa     1134

aaattgtaac aatatcactg taataataaa gttttgg                              1171


<210>  81
<211>  158
<212>  PRT
<213>  Mus musculus - IL-17A

<400>  81

Met Ser Pro Gly Arg Ala Ser Ser Val Ser Leu Met Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ser Leu Ala Ala Thr Val Lys Ala Ala Ala Ile Ile Pro Gln Ser 
            20                  25                  30          


Ser Ala Cys Pro Asn Thr Glu Ala Lys Asp Phe Leu Gln Asn Val Lys 
        35                  40                  45              


Val Asn Leu Lys Val Phe Asn Ser Leu Gly Ala Lys Val Ser Ser Arg 
    50                  55                  60                  


Arg Pro Ser Asp Tyr Leu Asn Arg Ser Thr Ser Pro Trp Thr Leu His 
65                  70                  75                  80  


Arg Asn Glu Asp Pro Asp Arg Tyr Pro Ser Val Ile Trp Glu Ala Gln 
                85                  90                  95      


Cys Arg His Gln Arg Cys Val Asn Ala Glu Gly Lys Leu Asp His His 
            100                 105                 110         


Met Asn Ser Val Leu Ile Gln Gln Glu Ile Leu Val Leu Lys Arg Glu 
        115                 120                 125             


Pro Glu Ser Cys Pro Phe Thr Phe Arg Val Glu Lys Met Leu Val Gly 
    130                 135                 140                 


Val Gly Cys Thr Cys Val Ala Ser Ile Val Arg Gln Ala Ala 
145                 150                 155             


<210>  82
<211>  1859
<212>  DNA
<213>  Homo sapiens - IL-17A


<220>
<221>  CDS
<222>  (46)..(513)

<400>  82
gcaggcacaa actcatccat ccccagttga ttggaagaaa caacg atg act cct ggg       57
                                                  Met Thr Pro Gly         
                                                  1                       

aag acc tca ttg gtg tca ctg cta ctg ctg ctg agc ctg gag gcc ata        105
Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser Leu Glu Ala Ile           
5                   10                  15                  20            

gtg aag gca gga atc aca atc cca cga aat cca gga tgc cca aat tct        153
Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser           
                25                  30                  35                

gag gac aag aac ttc ccc cgg act gtg atg gtc aac ctg aac atc cat        201
Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His           
            40                  45                  50                    

aac cgg aat acc aat acc aat ccc aaa agg tcc tca gat tac tac aac        249
Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn           
        55                  60                  65                        

cga tcc acc tca cct tgg aat ctc cac cgc aat gag gac cct gag aga        297
Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg           
    70                  75                  80                            

tat ccc tct gtg atc tgg gag gca aag tgc cgc cac ttg ggc tgc atc        345
Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile           
85                  90                  95                  100           

aac gct gat ggg aac gtg gac tac cac atg aac tct gtc ccc atc cag        393
Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln           
                105                 110                 115               

caa gag atc ctg gtc ctg cgc agg gag cct cca cac tgc ccc aac tcc        441
Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser           
            120                 125                 130                   

ttc cgg ctg gag aag ata ctg gtg tcc gtg ggc tgc acc tgt gtc acc        489
Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr           
        135                 140                 145                       

ccg att gtc cac cat gtg gcc taa gagctctggg gagcccacac tccccaaagc       543
Pro Ile Val His His Val Ala                                               
    150                 155                                               

agttagacta tggagagccg acccagcccc tcaggaaccc tcatccttca aagacagcct      603

catttcggac taaactcatt agagttctta aggcagtttg tccaattaaa gcttcagagg      663

taacacttgg ccaagatatg agatctgaat tacctttccc tctttccaag aaggaaggtt      723

tgactgagta ccaatttgct tcttgtttac ttttttaagg gctttaagtt atttatgtat      783

ttaatatgcc ctgagataac tttggggtat aagattccat tttaatgaat tacctacttt      843

attttgtttg tctttttaaa gaagataaga ttctgggctt gggaatttta ttatttaaaa      903

ggtaaaacct gtatttattt gagctattta aggatctatt tatgtttaag tatttagaaa      963

aaggtgaaaa agcactatta tcagttctgc ctaggtaaat gtaagataga attaaatggc     1023

agtgcaaaat ttctgagtct ttacaacata cggatatagt atttcctcct ctttgttttt     1083

aaaagttata acatggctga aaagaaagat taaacctact ttcatatgta ttaatttaaa     1143

ttttgcaatt tgttgaggtt ttacaagaga tacagcaagt ctaactctct gttccattaa     1203

acccttataa taaaatcctt ctgtaataat aaagtttcaa aagaaaatgt ttatttgttc     1263

tcattaaatg tattttagca aactcagctc ttccctattg ggaagagtta tgcaaattct     1323

cctataagca aaacaaagca tgtctttgag taacaatgac ctggaaatac ccaaaattcc     1383

aagttctcga tttcacatgc cttcaagact gaacaccgac taaggttttc atactattag     1443

ccaatgctgt agacagaagc attttgatag gaatagagca aataagataa tggccctgag     1503

gaatggcatg tcattattaa agatcatatg gggaaaatga aaccctcccc aaaatacaag     1563

aagttctggg aggagacatt gtcttcagac tacaatgtcc agtttctccc ctagactcag     1623

gcttcctttg gagattaagg cccctcagag atcaacagac caacattttt ctcttcctca     1683

agcaacactc ctagggcctg gcttctgtct gatcaaggca ccacacaacc cagaaaggag     1743

ctgatggggc agaacgaact ttaagtatga gaaaagttca gcccaagtaa aataaaaact     1803

caatcacatt caattccaga gtagtttcaa gtttcacatc gtaaccattt tcgccc         1859


<210>  83
<211>  155
<212>  PRT
<213>  Homo sapiens - IL-17A

<400>  83

Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210>  84
<211>  707
<212>  DNA
<213>  Mus musculus - IL-17B


<220>
<221>  CDS
<222>  (50)..(592)

<400>  84
ggggttcctg gcgggtggca gctgcgggcc tgccgcctga cttggtggg atg gac tgg       58
                                                      Met Asp Trp         
                                                      1                   

ccg cac agc ctg ctc ttc ctc ctg gcc atc tcc atc ttc ctg gcg cca        106
Pro His Ser Leu Leu Phe Leu Leu Ala Ile Ser Ile Phe Leu Ala Pro           
    5                   10                  15                            

agc cac ccc cgg aac acc aaa ggc aaa aga aaa ggg caa ggg agg ccc        154
Ser His Pro Arg Asn Thr Lys Gly Lys Arg Lys Gly Gln Gly Arg Pro           
20                  25                  30                  35            

agt ccc ttg gcc cct ggg cct cat cag gtg ccg ctg gac ctg gtg tct        202
Ser Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp Leu Val Ser           
                40                  45                  50                

cga gta aag ccc tac gct cga atg gaa gag tat gag cgg aac ctt ggg        250
Arg Val Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Leu Gly           
            55                  60                  65                    

gag atg gtg gcc cag ctg agg aac agc tcc gag cca gcc aag aag aaa        298
Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Pro Ala Lys Lys Lys           
        70                  75                  80                        

tgt gaa gtc aat cta cag ctg tgg ttg tcc aac aag agg agc ctg tcc        346
Cys Glu Val Asn Leu Gln Leu Trp Leu Ser Asn Lys Arg Ser Leu Ser           
    85                  90                  95                            

cca tgg ggc tac agc atc aac cac gac ccc agc cgc atc cct gcg gac        394
Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro Ala Asp           
100                 105                 110                 115           

ttg ccc gag gcg cgg tgc cta tgt ttg ggt tgc gtg aat ccc ttc acc        442
Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe Thr           
                120                 125                 130               

atg cag gag gac cgt agc atg gtg agc gtg cca gtg ttc agc cag gtg        490
Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe Ser Gln Val           
            135                 140                 145                   

ccg gtg cgc cgc cgc ctc tgt cct caa cct cct cgc cct ggg ccc tgc        538
Pro Val Arg Arg Arg Leu Cys Pro Gln Pro Pro Arg Pro Gly Pro Cys           
        150                 155                 160                       

cgc cag cgt gtc gtc atg gag acc atc gct gtg ggt tgc acc tgc atc        586
Arg Gln Arg Val Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys Ile           
    165                 170                 175                           

ttc tga gccaaccacc aacccggtgg cctctgcaac aaccctccct ccctgcaccc         642
Phe                                                                       
180                                                                       

actgtgaccc tcaaggctga taaacagtaa acgctgttct ttgtaaagga aaaaaaaaaa      702

aaaaa                                                                  707


<210>  85
<211>  180
<212>  PRT
<213>  Mus musculus - IL-17B

<400>  85

Met Asp Trp Pro His Ser Leu Leu Phe Leu Leu Ala Ile Ser Ile Phe 
1               5                   10                  15      


Leu Ala Pro Ser His Pro Arg Asn Thr Lys Gly Lys Arg Lys Gly Gln 
            20                  25                  30          


Gly Arg Pro Ser Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp 
        35                  40                  45              


Leu Val Ser Arg Val Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg 
    50                  55                  60                  


Asn Leu Gly Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Pro Ala 
65                  70                  75                  80  


Lys Lys Lys Cys Glu Val Asn Leu Gln Leu Trp Leu Ser Asn Lys Arg 
                85                  90                  95      


Ser Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile 
            100                 105                 110         


Pro Ala Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn 
        115                 120                 125             


Pro Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe 
    130                 135                 140                 


Ser Gln Val Pro Val Arg Arg Arg Leu Cys Pro Gln Pro Pro Arg Pro 
145                 150                 155                 160 


Gly Pro Cys Arg Gln Arg Val Val Met Glu Thr Ile Ala Val Gly Cys 
                165                 170                 175     


Thr Cys Ile Phe 
            180 


<210>  86
<211>  711
<212>  DNA
<213>  Homo sapiens - IL-17B


<220>
<221>  CDS
<222>  (51)..(593)

<400>  86
tggggttcca ggcgggcagc agctgcaggc tgaccttgca gcttggcgga atg gac          56
                                                       Met Asp            
                                                       1                  

tgg cct cac aac ctg ctg ttt ctt ctt acc att tcc atc ttc ctg ggg        104
Trp Pro His Asn Leu Leu Phe Leu Leu Thr Ile Ser Ile Phe Leu Gly           
        5                   10                  15                        

ctg ggc cag ccc agg agc ccc aaa agc aag agg aag ggg caa ggg cgg        152
Leu Gly Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln Gly Arg           
    20                  25                  30                            

cct ggg ccc ctg gcc cct ggc cct cac cag gtg cca ctg gac ctg gtg        200
Pro Gly Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp Leu Val           
35                  40                  45                  50            

tca cgg atg aaa ccg tat gcc cgc atg gag gag tat gag agg aac atc        248
Ser Arg Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Ile           
                55                  60                  65                

gag gag atg gtg gcc cag ctg agg aac agc tca gag ctg gcc cag aga        296
Glu Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala Gln Arg           
            70                  75                  80                    

aag tgt gag gtc aac ttg cag ctg tgg atg tcc aac aag agg agc ctg        344
Lys Cys Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg Ser Leu           
        85                  90                  95                        

tct ccc tgg ggc tac agc atc aac cac gac ccc agc cgt atc ccc gtg        392
Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro Val           
    100                 105                 110                           

gac ctg ccg gag gca cgg tgc ctg tgt ctg ggc tgt gtg aac ccc ttc        440
Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe           
115                 120                 125                 130           

acc atg cag gag gac cgc agc atg gtg agc gtg ccg gtg ttc agc cag        488
Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe Ser Gln           
                135                 140                 145               

gtt cct gtg cgc cgc cgc ctc tgc ccg cca ccg ccc cgc aca ggg cct        536
Val Pro Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr Gly Pro           
            150                 155                 160                   

tgc cgc cag cgc gca gtc atg gag acc atc gct gtg ggc tgc acc tgc        584
Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys           
        165                 170                 175                       

atc ttc tga atcacctggc ccagaagcca ggccagcagc ccgagaccat                633
Ile Phe                                                                   
    180                                                                   

cctccttgca cctttgtgcc aagaaaggcc tatgaaaagt aaacactgac ttttgaaagc      693

aaaaaaaaaa aaaaaaaa                                                    711


<210>  87
<211>  180
<212>  PRT
<213>  Homo sapiens - IL-17B

<400>  87

Met Asp Trp Pro His Asn Leu Leu Phe Leu Leu Thr Ile Ser Ile Phe 
1               5                   10                  15      


Leu Gly Leu Gly Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln 
            20                  25                  30          


Gly Arg Pro Gly Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp 
        35                  40                  45              


Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg 
    50                  55                  60                  


Asn Ile Glu Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala 
65                  70                  75                  80  


Gln Arg Lys Cys Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg 
                85                  90                  95      


Ser Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile 
            100                 105                 110         


Pro Val Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn 
        115                 120                 125             


Pro Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe 
    130                 135                 140                 


Ser Gln Val Pro Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr 
145                 150                 155                 160 


Gly Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys 
                165                 170                 175     


Thr Cys Ile Phe 
            180 


