
                                SEQUENCE LISTING

<110> Intradigm Corporation
      Xie, Frank Y.
      Yang, Xiaodong
      Liu, Ying

<120> COMPOSITIONS COMPRISING HUMAN PCSK9 AND
  	APOLIPOPROTEIN B siRNA AND METHODS OF USE
 
<130> 480251.408PC

<140> PCT                  
<141> 2009-03-09  

<160> 572

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 1
ucacgcgccc ugcuccugaa cuuca                                       25

<210> 2
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 2
ugaaguucag gagcagggcg cguga                                       25

<210> 3
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 3
gaggagcugg ugcuagccuu gcguu                                       25

<210> 4
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 4
aacgcaaggc uagcaccagc uccuc                                       25

<210> 5
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 5
gauaccucac caagauccug caugu                                       25

<210> 6
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 6
acaugcagga ucuuggugag guauc                                       25

<210> 7
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 7
cgacuacauc gaggaggacu ccucu                                       25

<210> 8
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 8
agaggagucc uccucgaugu agucg                                       25

<210> 9
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 9
caucgaggag gacuccucug ucuuu                                       25

<210> 10
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 10
aaagacagag gaguccuccu cgaug                                       25

<210> 11
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 11
gaggacuccu cugucuuugc ccaga                                       25

<210> 12
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 12
ucugggcaaa gacagaggag uccuc                                       25

<210> 13
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 13
gacuccucug ucuuugccca gagca                                       25

<210> 14
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 14
ugcucugggc aaagacagag gaguc                                       25

<210> 15
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 15
gaggcagccu gguggaggug uaucu                                       25

<210> 16
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 16
agauacaccu ccaccaggcu gccuc                                       25

<210> 17
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 17
gcagccuggu ggagguguau cuccu                                       25

<210> 18
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 18
aggagauaca ccuccaccag gcugc                                       25

<210> 19
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 19
cagccuggug gagguguauc uccua                                       25

<210> 20
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 20
uaggagauac accuccacca ggcug                                       25

<210> 21
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 21
gccuggugga gguguaucuc cuaga                                       25

<210> 22
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 22
ucuaggagau acaccuccac caggc                                       25

<210> 23
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 23
gguguaucuc cuagacacca gcaua                                       25

<210> 24
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 24
uaugcuggug ucuaggagau acacc                                       25

<210> 25
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 25
ccagcauaca gagugaccac cggga                                       25

<210> 26
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 26
ucccgguggu cacucuguau gcugg                                       25

<210> 27
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 27
gcauacagag ugaccaccgg gaaau                                       25

<210> 28
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 28
auuucccggu ggucacucug uaugc                                       25

<210> 29
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 29
gaaaucgagg gcagggucau gguca                                       25

<210> 30
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 30
ugaccaugac ccugcccucg auuuc                                       25

<210> 31
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 31
ccgacuucga gaaugugccc gagga                                       25

<210> 32
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 32
uccucgggca cauucucgaa gucgg                                       25

<210> 33
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 33
acaggccagc aagugugaca gucau                                       25

<210> 34
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 34
augacuguca cacuugcugg ccugu                                       25

<210> 35
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 35
ugcgcgugcu caacugccaa gggaa                                       25

<210> 36
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 36
uucccuuggc aguugagcac gcgca                                       25

<210> 37
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 37
ggcacccuca uaggccugga guuua                                       25

<210> 38
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 38
uaaacuccag gccuaugagg gugcc                                       25

<210> 39
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 39
gcacccucau aggccuggag uuuau                                       25

<210> 40
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 40
auaaacucca ggccuaugag ggugc                                       25

<210> 41
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 41
cacccucaua ggccuggagu uuauu                                       25

<210> 42
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 42
aauaaacucc aggccuauga gggug                                       25

<210> 43
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 43
cauaggccug gaguuuauuc ggaaa                                       25

<210> 44
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 44
uuuccgaaua aacuccaggc cuaug                                       25

<210> 45
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 45
ggaccaacuu uggccgcugu gugga                                       25

<210> 46
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 46
uccacacagc ggccaaaguu ggucc                                       25

<210> 47
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 47
acuuuggccg cuguguggac cucuu                                       25

<210> 48
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 48
aagaggucca cacagcggcc aaagu                                       25

<210> 49
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 49
gggaggacau cauuggugcc uccag                                       25

<210> 50
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 50
cuggaggcac caaugauguc cuccc                                       25

<210> 51
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 51
gaggacauca uuggugccuc cagcg                                       25

<210> 52
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 52
cgcuggaggc accaaugaug uccuc                                       25

<210> 53
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 53
gacaucauug gugccuccag cgacu                                       25

<210> 54
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 54
agucgcugga ggcaccaaug auguc                                       25

<210> 55
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 55
caggacugua uggucagcac acucg                                       25

<210> 56
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 56
cgagugugcu gaccauacag uccug                                       25

<210> 57
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 57
ggccuacgcc guagacaaca cgugu                                       25

<210> 58
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 58
acacguguug ucuacggcgu aggcc                                       25

<210> 59
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 59
gccuacgccg uagacaacac gugug                                       25

<210> 60
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 60
cacacguguu gucuacggcg uaggc                                       25

<210> 61
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 61
ccuacgccgu agacaacacg ugugu                                       25

<210> 62
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 62
acacacgugu ugucuacggc guagg                                       25

<210> 63
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 63
acgccguaga caacacgugu guagu                                       25

<210> 64
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 64
acuacacacg uguugucuac ggcgu                                       25

<210> 65
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 65
ccguagacaa cacgugugua gucag                                       25

<210> 66
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 66
cugacuacac acguguuguc uacgg                                       25

<210> 67
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 67
uguguaguca ggagccggga cguca                                       25

<210> 68
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 68
ugacgucccg gcuccugacu acaca                                       25

<210> 69
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 69
gacgucagca cuacaggcag cacca                                       25

<210> 70
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 70
uggugcugcc uguagugcug acguc                                       25

<210> 71
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 71
cagcacuaca ggcagcacca gcgaa                                       25

<210> 72
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 72
uucgcuggug cugccuguag ugcug                                       25

<210> 73
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 73
ccuccuugcc uggaacucac ucacu                                       25

<210> 74
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 74
agugagugag uuccaggcaa ggagg                                       25

<210> 75
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 75
ccauucaaac aggucgagcu gugcu                                       25

<210> 76
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 76
agcacagcuc gaccuguuug aaugg                                       25

<210> 77
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 77
ccgauguccg ugggcagaau gacuu                                       25

<210> 78
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 78
aagucauucu gcccacggac aucgg                                       25

<210> 79
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 79
cgauguccgu gggcagaaug acuuu                                       25

<210> 80
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 80
aaagucauuc ugcccacgga caucg                                       25

<210> 81
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 81
ucuuguuccg ugccaggcau ucaau                                       25

<210> 82
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 82
auugaaugcc uggcacggaa caaga                                       25

<210> 83
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 83
gccaggcauu caauccucag gucuc                                       25

<210> 84
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 84
gagaccugag gauugaaugc cuggc                                       25

<210> 85
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 85
aggaggcagg auucuuccca uggau                                       25

<210> 86
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 86
auccauggga agaauccugc cuccu                                       25

<210> 87
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 87
ggaggcagga uucuucccau ggaua                                       25

<210> 88
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 88
uauccauggg aagaauccug ccucc                                       25

<210> 89
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 89
gggugagugu gaaaggugcu gaugg                                       25

<210> 90
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 90
ccaucagcac cuuucacacu caccc                                       25

<210> 91
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 91
ugaaaggugc ugauggcccu caucu                                       25

<210> 92
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 92
agaugagggc caucagcacc uuuca                                       25

<210> 93
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 93
gcccucaucu ccagcuaacu gugga                                       25

<210> 94
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 94
uccacaguua gcuggagaug agggc                                       25

<210> 95
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 95
cccugauuaa uggaggcuua gcuuu                                       25

<210> 96
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 96
aaagcuaagc cuccauuaau caggg                                       25

<210> 97
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 97
ggaggcuuag cuuucuggau ggcau                                       25

<210> 98
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 98
augccaucca gaaagcuaag ccucc                                       25

<210> 99
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 99
ggauggcauc uagccagagg cugga                                       25

<210> 100
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 100
uccagccucu ggcuagaugc caucc                                       25

<210> 101
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 101
ccaggcugug cuagcaacac ccaaa                                       25

<210> 102
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 102
uuuggguguu gcuagcacag ccugg                                       25

<210> 103
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 103
cacuacccgg caggguacac auucg                                       25

<210> 104
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 104
cgaaugugua cccugccggg uagug                                       25

<210> 105
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 105
cagcaggaac ugagccagaa acgca                                       25

<210> 106
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 106
ugcguuucug gcucaguucc ugcug                                       25

<210> 107
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 107
cagaaacgca gauugggcug gcucu                                       25

<210> 108
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 108
agagccagcc caaucugcgu uucug                                       25

<210> 109
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 109
aaacgcagau ugggcuggcu cugaa                                       25

<210> 110
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      PCSK9

<400> 110
uucagagcca gcccaaucug cguuu                                       25

<210> 111
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 111
gccauuccag aagggaagca gguuu                                       25

<210> 112
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 112
aaaccugcuu cccuucugga auggc                                       25

<210> 113
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 113
aagaugaacc uacuuacauc cugaa                                       25

<210> 114
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 114
uucaggaugu aaguagguuc aucuu                                       25

<210> 115
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 115
gaugaaccua cuuacauccu gaaca                                       25

<210> 116
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 116
uguucaggau guaaguaggu ucauc                                       25

<210> 117
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 117
gaaccuacuu acauccugaa cauca                                       25

<210> 118
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 118
ugauguucag gauguaagua gguuc                                       25

<210> 119
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 119
aaccuacuua cauccugaac aucaa                                       25

<210> 120
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 120
uugauguuca ggauguaagu agguu                                       25

<210> 121
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 121
uccacucacu uuaccgucaa gacga                                       25

<210> 122
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 122
ucgucuugac gguaaaguga gugga                                       25

<210> 123
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 123
gaggaagggc aauguggcaa cagaa                                       25

<210> 124
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 124
uucuguugcc acauugcccu uccuc                                       25

<210> 125
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 125
gaagggcaau guggcaacag aaaua                                       25

<210> 126
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 126
uauuucuguu gccacauugc ccuuc                                       25

<210> 127
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 127
uguggcaaca gaaauaucca cugaa                                       25

<210> 128
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 128
uucaguggau auuucuguug ccaca                                       25

<210> 129
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 129
gaauaaguau gggaugguag cacaa                                       25

<210> 130
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 130
uugugcuacc aucccauacu uauuc                                       25

<210> 131
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 131
cagccgcuuc uuuggugaag guacu                                       25

<210> 132
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 132
aguaccuuca ccaaagaagc ggcug                                       25

<210> 133
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 133
ggccucgcau uugagagcac caaau                                       25

<210> 134
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 134
auuuggugcu cucaaaugcg aggcc                                       25

<210> 135
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 135
ccucagugau gaagcaguca caucu                                       25

<210> 136
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 136
agaugugacu gcuucaucac ugagg                                       25

<210> 137
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 137
caacuaucau aagacaaacc cuaca                                       25

<210> 138
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 138
uguaggguuu gucuuaugau aguug                                       25

<210> 139
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 139
aaccauggag caguuaacuc cagaa                                       25

<210> 140
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 140
uucuggaguu aacugcucca ugguu                                       25

<210> 141
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 141
acaaggacca ggagguucuu cuuca                                       25

<210> 142
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 142
ugaagaagaa ccuccugguc cuugu                                       25

<210> 143
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 143
agauaagcga cuggcugccu aucuu                                       25

<210> 144
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 144
aagauaggca gccagucgcu uaucu                                       25

<210> 145
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 145
gauaagcgac uggcugccua ucuua                                       25

<210> 146
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 146
uaagauaggc agccagucgc uuauc                                       25

<210> 147
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 147
gacuggcugc cuaucuuaug uugau                                       25

<210> 148
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 148
aucaacauaa gauaggcagc caguc                                       25

<210> 149
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 149
gcugccuauc uuauguugau gagga                                       25

<210> 150
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 150
uccucaucaa cauaagauag gcagc                                       25

<210> 151
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 151
caugggaaca gaaugagcaa gugaa                                       25

<210> 152
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 152
uucacuugcu cauucuguuc ccaug                                       25

<210> 153
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 153
gaaagaagcu cugaaagaau cucaa                                       25

<210> 154
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 154
uugagauucu uucagagcuu cuuuc                                       25

<210> 155
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 155
gaaagaaucu caacuuccaa cuguc                                       25

<210> 156
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 156
gacaguugga aguugagauu cuuuc                                       25

<210> 157
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 157
caacuuccaa cugucaugga cuuca                                       25

<210> 158
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 158
ugaaguccau gacaguugga aguug                                       25

<210> 159
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 159
caaaucuguu ucucuuccau cacuu                                       25

<210> 160
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 160
aagugaugga agagaaacag auuug                                       25

<210> 161
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 161
cacugccuuu ggauuugcuu cagcu                                       25

<210> 162
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 162
agcugaagca aauccaaagg cagug                                       25

<210> 163
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 163
cagcugaccu caucgagauu ggcuu                                       25

<210> 164
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 164
aagccaaucu cgaugagguc agcug                                       25

<210> 165
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 165
ugaccucauc gagauuggcu uggaa                                       25

<210> 166
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 166
uuccaagcca aucucgauga gguca                                       25

<210> 167
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 167
cagacagugu caacaaagcu uugua                                       25

<210> 168
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 168
uacaaagcuu uguugacacu gucug                                       25

<210> 169
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 169
caacaaagcu uuguacuggg uuaau                                       25

<210> 170
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 170
auuaacccag uacaaagcuu uguug                                       25

<210> 171
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 171
gguuaauggu caaguuccug auggu                                       25

<210> 172
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 172
accaucagga acuugaccau uaacc                                       25

<210> 173
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 173
ggucaaguuc cugauggugu cucua                                       25

<210> 174
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 174
uagagacacc aucaggaacu ugacc                                       25

<210> 175
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 175
ucuaaggucu uaguggacca cuuug                                       25

<210> 176
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 176
caaagugguc cacuaagacc uuaga                                       25

<210> 177
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 177
ugauaaacau gagcaggaua uggua                                       25

<210> 178
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 178
uaccauaucc ugcucauguu uauca                                       25

<210> 179
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 179
caugagcagg auaugguaaa uggaa                                       25

<210> 180
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 180
uuccauuuac cauauccugc ucaug                                       25

<210> 181
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 181
caucuucaug gagaaugccu uugaa                                       25

<210> 182
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 182
uucaaaggca uucuccauga agaug                                       25

<210> 183
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 183
ccacuggagc uggauuacag uugca                                       25

<210> 184
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 184
ugcaacugua auccagcucc agugg                                       25

<210> 185
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 185
ggagcuggau uacaguugca aauau                                       25

<210> 186
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 186
auauuugcaa cuguaaucca gcucc                                       25

<210> 187
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 187
gagcuggauu acaguugcaa auauc                                       25

<210> 188
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 188
gauauuugca acuguaaucc agcuc                                       25

<210> 189
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 189
ccaaagagac cagucaagcu gcuca                                       25

<210> 190
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 190
ugagcagcuu gacuggucuc uuugg                                       25

<210> 191
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 191
aaacggaggu gaucccaccu cucau                                       25

<210> 192
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 192
augagaggug ggaucaccuc cguuu                                       25

<210> 193
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 193
ccucucauug agaacaggca guccu                                       25

<210> 194
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 194
aggacugccu guucucaaug agagg                                       25

<210> 195
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 195
gagaacaggc aguccugguc aguuu                                       25

<210> 196
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 196
aaacugacca ggacugccug uucuc                                       25

<210> 197
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 197
caguccuggu caguuugcaa gcaag                                       25

<210> 198
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 198
cuugcuugca aacugaccag gacug                                       25

<210> 199
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 199
ccuggucagu uugcaagcaa gucuu                                       25

<210> 200
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 200
aagacuugcu ugcaaacuga ccagg                                       25

<210> 201
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 201
ccuacaggag agauugagca guauu                                       25

<210> 202
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 202
aauacugcuc aaucucuccu guagg                                       25

<210> 203
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 203
gauugagcag uauucuguca gcgca                                       25

<210> 204
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 204
ugcgcugaca gaauacugcu caauc                                       25

<210> 205
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 205
gcaguauucu gucagcgcaa ccuau                                       25

<210> 206
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 206
auagguugcg cugacagaau acugc                                       25

<210> 207
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 207
gaagcagacu gaggcuacca ugaca                                       25

<210> 208
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 208
ugucauggua gccucagucu gcuuc                                       25

<210> 209
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 209
aagcagacug aggcuaccau gacau                                       25

<210> 210
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 210
augucauggu agccucaguc ugcuu                                       25

<210> 211
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 211
cagacugagg cuaccaugac auuca                                       25

<210> 212
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 212
ugaaugucau gguagccuca gucug                                       25

<210> 213
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 213
gaggcuacca ugacauucaa auaua                                       25

<210> 214
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 214
uauauuugaa ugucauggua gccuc                                       25

<210> 215
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 215
ccaugacauu caaauauaau cggca                                       25

<210> 216
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 216
ugccgauuau auuugaaugu caugg                                       25

<210> 217
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 217
uccgauuauc cuaagagcuu gcaua                                       25

<210> 218
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 218
uaugcaagcu cuuaggauaa ucgga                                       25

<210> 219
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 219
gagcuugcau auguaugcua auaga                                       25

<210> 220
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 220
ucuauuagca uacauaugca agcuc                                       25

<210> 221
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 221
uguaugcuaa uagacuccug gauca                                       25

<210> 222
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 222
ugauccagga gucuauuagc auaca                                       25

<210> 223
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 223
cagagucccu caaacagaca ugacu                                       25

<210> 224
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 224
agucaugucu guuugaggga cucug                                       25

<210> 225
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 225
ccggcacgug gguuccaaau uaaua                                       25

<210> 226
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 226
uauuaauuug gaacccacgu gccgg                                       25

<210> 227
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 227
cagaaggcau cugggagucu uccuu                                       25

<210> 228
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 228
aaggaagacu cccagaugcc uucug                                       25

<210> 229
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 229
agaaggcauc ugggagucuu ccuua                                       25

<210> 230
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 230
uaaggaagac ucccagaugc cuucu                                       25

<210> 231
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 231
gaaggcaucu gggagucuuc cuuau                                       25

<210> 232
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 232
auaaggaaga cucccagaug ccuuc                                       25

<210> 233
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 233
cccagacuuu gcaagaccac cucaa                                       25

<210> 234
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 234
uugagguggu cuugcaaagu cuggg                                       25

<210> 235
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 235
ccauucccaa guuguaucaa cugca                                       25

<210> 236
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 236
ugcaguugau acaacuuggg aaugg                                       25

<210> 237
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 237
cauucccaag uuguaucaac ugcaa                                       25

<210> 238
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 238
uugcaguuga uacaacuugg gaaug                                       25

<210> 239
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 239
uccacgaaug ucuacagcaa cuugu                                       25

<210> 240
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 240
acaaguugcu guagacauuc gugga                                       25

<210> 241
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 241
ccacgaaugu cuacagcaac uugua                                       25

<210> 242
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 242
uacaaguugc uguagacauu cgugg                                       25

<210> 243
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 243
gcaaggaucu ggagaaacaa cauau                                       25

<210> 244
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 244
auauguuguu ucuccagauc cuugc                                       25

<210> 245
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 245
cacacuauca ugugaugggu cucua                                       25

<210> 246
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 246
uagagaccca ucacaugaua gugug                                       25

<210> 247
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 247
acgccacaaa uuucuagauu cgaau                                       25

<210> 248
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 248
auucgaaucu agaaauuugu ggcgu                                       25

<210> 249
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 249
ugcuucaguu cauuuggacu ccaaa                                       25

<210> 250
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 250
uuuggagucc aaaugaacug aagca                                       25

<210> 251
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 251
cagcauuugu uugucaaaga aguca                                       25

<210> 252
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 252
ugacuucuuu gacaaacaaa ugcug                                       25

<210> 253
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 253
gaagucaaga uugaugggca guuca                                       25

<210> 254
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 254
ugaacugccc aucaaucuug acuuc                                       25

<210> 255
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 255
gggcaguuca gagucucuuc guucu                                       25

<210> 256
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 256
agaacgaaga gacucugaac ugccc                                       25

<210> 257
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 257
caguucagag ucucuucguu cuaug                                       25

<210> 258
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 258
cauagaacga agagacucug aacug                                       25

<210> 259
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 259
uaccuccaag gcaccaacca gauaa                                       25

<210> 260
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 260
uuaucugguu ggugccuugg aggua                                       25

<210> 261
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 261
gaaguauaag aacuuugcca cuucu                                       25

<210> 262
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 262
agaaguggca aaguucuuau acuuc                                       25

<210> 263
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 263
aaaugcacug cugcguucug aauau                                       25

<210> 264
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 264
auauucagaa cgcagcagug cauuu                                       25

<210> 265
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 265
ugcguucuga auaucaggcu gauua                                       25

<210> 266
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 266
uaaucagccu gauauucaga acgca                                       25

<210> 267
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 267
gaauaucagg cugauuacga gucau                                       25

<210> 268
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 268
augacucgua aucagccuga uauuc                                       25

<210> 269
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 269
gauuacgagu cauugagguu cuuca                                       25

<210> 270
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 270
ugaagaaccu caaugacucg uaauc                                       25

<210> 271
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 271
cacuaaauuc ccauggucuu gaguu                                       25

<210> 272
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 272
aacucaagac caugggaauu uagug                                       25

<210> 273
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 273
ccaagaugga auaucuacca gugca                                       25

<210> 274
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 274
ugcacuggua gauauuccau cuugg                                       25

<210> 275
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 275
ucuaccagug caacgaccaa cuuga                                       25

<210> 276
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 276
ucaaguuggu cguugcacug guaga                                       25

<210> 277
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 277
ccaacuugaa guguagucuc cuggu                                       25

<210> 278
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 278
accaggagac uacacuucaa guugg                                       25

<210> 279
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 279
acuugaagug uagucuccug gugcu                                       25

<210> 280
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 280
agcaccagga gacuacacuu caagu                                       25

<210> 281
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 281
gccgcuucag ggaacacaau gcaaa                                       25

<210> 282
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 282
uuugcauugu guucccugaa gcggc                                       25

<210> 283
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 283
gggaagugcu uaucaggcca ugauu                                       25

<210> 284
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 284
aaucauggcc ugauaagcac uuccc                                       25

<210> 285
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 285
gaugggcuca uaugcugaaa ugaaa                                       25

<210> 286
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 286
uuucauuuca gcauaugagc ccauc                                       25

<210> 287
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 287
cagucugaac auugcaggcu uauca                                       25

<210> 288
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 288
ugauaagccu gcaauguuca gacug                                       25

<210> 289
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 289
gcccuauucu cugguaacua cuuua                                       25

<210> 290
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 290
uaaaguaguu accagagaau agggc                                       25

<210> 291
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 291
cccuauucuc ugguaacuac uuuaa                                       25

<210> 292
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 292
uuaaaguagu uaccagagaa uaggg                                       25

<210> 293
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 293
gaagcugcau guggcuggua accua                                       25

<210> 294
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 294
uagguuacca gccacaugca gcuuc                                       25

<210> 295
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 295
aagcugcaug uggcugguaa ccuaa                                       25

<210> 296
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 296
uuagguuacc agccacaugc agcuu                                       25

<210> 297
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 297
gcuaagguuc agggugugga guuua                                       25

<210> 298
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 298
uaaacuccac acccugaacc uuagc                                       25

<210> 299
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 299
gagcacaaac uauaauucag acuca                                       25

<210> 300
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 300
ugagucugaa uuauaguuug ugcuc                                       25

<210> 301
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 301
cacaaacuau aauucagacu cacug                                       25

<210> 302
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 302
cagugagucu gaauuauagu uugug                                       25

<210> 303
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 303
gacucacugc auuucagcaa ugucu                                       25

<210> 304
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 304
agacauugcu gaaaugcagu gaguc                                       25

<210> 305
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 305
ccaugaccau cgaugcacau acaaa                                       25

<210> 306
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 306
uuuguaugug caucgauggu caugg                                       25

<210> 307
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 307
caugaccauc gaugcacaua caaau                                       25

<210> 308
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 308
auuuguaugu gcaucgaugg ucaug                                       25

<210> 309
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 309
caucgaugca cauacaaaug gcaau                                       25

<210> 310
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 310
auugccauuu guaugugcau cgaug                                       25

<210> 311
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 311
gaugcacaua caaauggcaa uggga                                       25

<210> 312
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 312
ucccauugcc auuuguaugu gcauc                                       25

<210> 313
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 313
ccucuggcau uuacuuucuc ucaug                                       25

<210> 314
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 314
caugagagaa aguaaaugcc agagg                                       25

<210> 315
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 315
gaacacaaag ucagugcccu gcuua                                       25

<210> 316
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 316
uaagcagggc acugacuuug uguuc                                       25

<210> 317
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 317
accuggaaac ucaagaccca auuua                                       25

<210> 318
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 318
uaaauugggu cuugaguuuc caggu                                       25

<210> 319
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 319
ccuggaaacu caagacccaa uuuaa                                       25

<210> 320
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 320
uuaaauuggg ucuugaguuu ccagg                                       25

<210> 321
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 321
caggacuugg augcuuacaa cacua                                       25

<210> 322
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 322
uaguguugua agcauccaag uccug                                       25

<210> 323
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 323
uggacgaacu cuggcugacc uaacu                                       25

<210> 324
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 324
aguuagguca gccagaguuc gucca                                       25

<210> 325
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 325
gaacucuggc ugaccuaacu cuacu                                       25

<210> 326
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 326
aguagaguua ggucagccag aguuc                                       25

<210> 327
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 327
cagagaaacc ugaagcacau caaua                                       25

<210> 328
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 328
uauugaugug cuucagguuu cucug                                       25

<210> 329
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 329
acucccacag caagcuaaug auuau                                       25

<210> 330
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 330
auaaucauua gcuugcugug ggagu                                       25

<210> 331
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 331
ccacagcaag cuaaugauua ucuga                                       25

<210> 332
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 332
ucagauaauc auuagcuugc ugugg                                       25

<210> 333
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 333
cacagcaagc uaaugauuau cugaa                                       25

<210> 334
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 334
uucagauaau cauuagcuug cugug                                       25

<210> 335
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 335
agcagcuuaa gagacacaua cagaa                                       25

<210> 336
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 336
uucuguaugu gucucuuaag cugcu                                       25

<210> 337
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 337
cagcuuaaga gacacauaca gaaua                                       25

<210> 338
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 338
uauucuguau gugucucuua agcug                                       25

<210> 339
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 339
gaggcuauug auguuagagu gcuuu                                       25

<210> 340
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 340
aaagcacucu aacaucaaua gccuc                                       25

<210> 341
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 341
uaaaugacgu ucuugagcau gucaa                                       25

<210> 342
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 342
uugacaugcu caagaacguc auuua                                       25

<210> 343
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 343
aguccaugag uuaaucgaga gguau                                       25

<210> 344
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 344
auaccucucg auuaacucau ggacu                                       25

<210> 345
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 345
cgagagguau gaaguagacc aacaa                                       25

<210> 346
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 346
uuguuggucu acuucauacc ucucg                                       25

<210> 347
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 347
gagagguaug aaguagacca acaaa                                       25

<210> 348
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 348
uuuguugguc uacuucauac cucuc                                       25

<210> 349
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 349
gguaugaagu agaccaacaa aucca                                       25

<210> 350
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 350
uggauuuguu ggucuacuuc auacc                                       25

<210> 351
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 351
gaaguagacc aacaaaucca gguuu                                       25

<210> 352
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 352
aaaccuggau uuguuggucu acuuc                                       25

<210> 353
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 353
uaguagaguu ggcccaccaa uacaa                                       25

<210> 354
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 354
aaguauuggu gggccaacuc uacua                                       25

<210> 355
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 355
ccaauacaag uugaaggaga cuauu                                       25

<210> 356
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 356
aauagucucc uucaacuugu auugg                                       25

<210> 357
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 357
caccaguuug uagaugaaac caaug                                       25

<210> 358
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 358
cauugguuuc aucuacaaac uggug                                       25

<210> 359
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 359
caguuuguag augaaaccaa ugaca                                       25

<210> 360
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 360
ugucauuggu uucaucuaca aacug                                       25

<210> 361
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 361
uccgugaggu gacucagaga cucaa                                       25

<210> 362
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 362
uugagucucu gagucaccuc acgga                                       25

<210> 363
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 363
ccuuaaucau caauugguua cagga                                       25

<210> 364
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 364
uccuguaacc aauugaugau uaagg                                       25

<210> 365
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 365
caucaauugg uuacaggagg cuuua                                       25

<210> 366
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 366
uaaagccucc uguaaccaau ugaug                                       25

<210> 367
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 367
caggaggcuu uaaguucagc aucuu                                       25

<210> 368
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 368
aagaugcuga acuuaaagcc uccug                                       25

<210> 369
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 369
ggaggcuuua aguucagcau cuuug                                       25

<210> 370
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 370
caaagaugcu gaacuuaaag ccucc                                       25

<210> 371
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 371
ccgaauguau caaauggaca uucag                                       25

<210> 372
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 372
cugaaugucc auuugauaca uucgg                                       25

<210> 373
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 373
uaccugucuc ugguaggcca gguuu                                       25

<210> 374
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 374
aaaccuggcc uaccagagac aggua                                       25

<210> 375
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 375
accugucucu gguaggccag guuua                                       25

<210> 376
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 376
uaaaccuggc cuaccagaga caggu                                       25

<210> 377
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 377
cagagcaaua uucuauccaa gauug                                       25

<210> 378
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 378
caaucuugga uagaauauug cucug                                       25

<210> 379
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 379
ggcuaaacgu augaaagcau uggua                                       25

<210> 380
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 380
uaccaaugcu uucauacguu uagcc                                       25

<210> 381
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 381
agcaaggguu cacuguuccu gaaau                                       25

<210> 382
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 382
auuucaggaa cagugaaccc uugcu                                       25

<210> 383
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 383
ccuaacagau uugaggauuc cauca                                       25

<210> 384
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 384
ugauggaauc cucaaaucug uuagg                                       25

<210> 385
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 385
aacagauuug aggauuccau caguu                                       25

<210> 386
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 386
aacugaugga auccucaaau cuguu                                       25

<210> 387
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 387
cagauuugag gauuccauca guuca                                       25

<210> 388
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 388
ugaacugaug gaauccucaa aucug                                       25

<210> 389
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 389
uccacaccag aauuuaccau ccuua                                       25

<210> 390
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 390
uaaggauggu aaauucuggu gugga                                       25

<210> 391
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 391
acaccagaau uuaccauccu uaaca                                       25

<210> 392
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 392
uguuaaggau gguaaauucu ggugu                                       25

<210> 393
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 393
cagaauuuac cauccuuaac accuu                                       25

<210> 394
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 394
aagguguuaa ggaugguaaa uucug                                       25

<210> 395
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 395
uaacaccuuc cacauuccuu ccuuu                                       25

<210> 396
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 396
aaaggaagga auguggaagg uguua                                       25

<210> 397
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 397
caccuuccac auuccuuccu uuaca                                       25

<210> 398
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 398
uguaaaggaa ggaaugugga aggug                                       25

<210> 399
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 399
uagcgagaau cacccugcca gacuu                                       25

<210> 400
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 400
aagucuggca gggugauucu cgcua                                       25

<210> 401
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 401
ugccagacuu ccguuuacca gaaau                                       25

<210> 402
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 402
auuucuggua aacggaaguc uggca                                       25

<210> 403
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 403
ccagaauuca uaaucccaac ucuca                                       25

<210> 404
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 404
ugagaguugg gauuaugaau ucugg                                       25

<210> 405
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 405
cagaauucau aaucccaacu cucaa                                       25

<210> 406
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 406
uugagaguug ggauuaugaa uucug                                       25

<210> 407
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 407
ucauaauccc aacucucaac cuuaa                                       25

<210> 408
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 408
uuaagguuga gaguugggau uauga                                       25

<210> 409
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 409
ucccaacucu caaccuuaau gauuu                                       25

<210> 410
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 410
aaaucauuaa gguugagagu uggga                                       25

<210> 411
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 411
cacacacaau ugaaguaccu acuuu                                       25

<210> 412
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 412
aaaguaggua cuucaauugu gugug                                       25

<210> 413
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 413
ccaccucagc aaacgaagca gguau                                       25

<210> 414
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 414
auaccugcuu cguuugcuga ggugg                                       25

<210> 415
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 415
gcacaacucu caaacccuaa gauua                                       25

<210> 416
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 416
uaaucuuagg guuugagagu ugugc                                       25

<210> 417
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 417
cacaacucuc aaacccuaag auuaa                                       25

<210> 418
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 418
uuaaucuuag gguuugagag uugug                                       25

<210> 419
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 419
ugggccacag uguucuaacu gcuaa                                       25

<210> 420
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 420
uuagcaguua gaacacugug gccca                                       25

<210> 421
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 421
gggccacagu guucuaacug cuaaa                                       25

<210> 422
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 422
uuuagcaguu agaacacugu ggccc                                       25

<210> 423
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 423
ccacaaacaa ugaagggaau uugaa                                       25

<210> 424
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 424
uucaaauucc cuucauuguu ugugg                                       25

<210> 425
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 425
ccauuaaggu uaacagggaa gauag                                       25

<210> 426
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 426
cuaucuuccc uguuaaccuu aaugg                                       25

<210> 427
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 427
acagggaaga uagacuuccu gaaua                                       25

<210> 428
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 428
uauucaggaa gucuaucuuc ccugu                                       25

<210> 429
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 429
cagggaagau agacuuccug aauaa                                       25

<210> 430
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 430
uuauucagga agucuaucuu cccug                                       25

<210> 431
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 431
ggaagauaga cuuccugaau aacua                                       25

<210> 432
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 432
uaguuauuca ggaagucuau cuucc                                       25

<210> 433
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 433
cgagaacauu auggaggccc augua                                       25

<210> 434
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 434
uacaugggcc uccauaaugu ucucg                                       25

<210> 435
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 435
caaacacagg cauuccauca caaau                                       25

<210> 436
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 436
auuugugaug gaaugccugu guuug                                       25

<210> 437
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 437
ccuuuggcug ugcuuuguga guuua                                       25

<210> 438
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 438
uaaacucaca aagcacagcc aaagg                                       25

<210> 439
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 439
gccaguccuu caugucccua gaaau                                       25

<210> 440
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 440
auuucuaggg acaugaagga cuggc                                       25

<210> 441
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 441
caugucccua gaaaucucaa gcuuu                                       25

<210> 442
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 442
aaagcuugag auuucuaggg acaug                                       25

<210> 443
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 443
ccaugggcaa uauuaccuau gauuu                                       25

<210> 444
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 444
aaaucauagg uaauauugcc caugg                                       25

<210> 445
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 445
caagugucau cacacugaau accaa                                       25

<210> 446
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 446
uugguauuca gugugaugac acuug                                       25

<210> 447
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 447
caucacacug aauaccaaug cugaa                                       25

<210> 448
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 448
uucagcauug guauucagug ugaug                                       25

<210> 449
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 449
caucugucau ugaugcacug cagua                                       25

<210> 450
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 450
uacugcagug caucaaugac agaug                                       25

<210> 451
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 451
caguacaaau uagagggcac cacaa                                       25

<210> 452
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 452
uuguggugcc cucuaauuug uacug                                       25

<210> 453
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 453
caacaaauuu guggagggua gucau                                       25

<210> 454
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 454
augacuaccc uccacaaauu uguug                                       25

<210> 455
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 455
cauaacagua cugugagcuu aacca                                       25

<210> 456
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 456
ugguuaagcu cacaguacug uuaug                                       25

<210> 457
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 457
caguacugug agcuuaacca cgaaa                                       25

<210> 458
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 458
uuucgugguu aagcucacag uacug                                       25

<210> 459
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 459
agucaucuac caaaggagau gucaa                                       25

<210> 460
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 460
uugacaucuc cuuugguaga ugacu                                       25

<210> 461
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 461
ucuaccaaag gagaugucaa ggguu                                       25

<210> 462
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 462
aacccuugac aucuccuuug guaga                                       25

<210> 463
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 463
caaggguucg guucuuucuc gggaa                                       25

<210> 464
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 464
uucccgagaa agaaccgaac ccuug                                       25

<210> 465
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 465
cgggaauauu caggaacuau ugcua                                       25

<210> 466
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 466
uagcaauagu uccugaauau ucccg                                       25

<210> 467
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 467
gaggccaaca cuuacuugaa uucca                                       25

<210> 468
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 468
uggaauucaa guaaguguug gccuc                                       25

<210> 469
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 469
aggccaacac uuacuugaau uccaa                                       25

<210> 470
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 470
auggaauuca aguaaguguu ggccu                                       25

<210> 471
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 471
uccauggcaa augucagcuc uuguu                                       25

<210> 472
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 472
aacaagagcu gacauuugcc augga                                       25

<210> 473
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 473
cauggcaaau gucagcucuu guuca                                       25

<210> 474
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 474
ugaacaagag cugacauuug ccaug                                       25

<210> 475
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 475
ccagcauugg uaggagacag caucu                                       25

<210> 476
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 476
agaugcuguc uccuaccaau gcugg                                       25

<210> 477
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 477
gccuacguuc caugucccau uuaca                                       25

<210> 478
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 478
uguaaauggg acauggaacg uaggc                                       25

<210> 479
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 479
ucgugcaaac uugacuucag agaaa                                       25

<210> 480
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 480
uuucucugaa gucaaguuug cacga                                       25

<210> 481
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 481
cgugcaaacu ugacuucaga gaaau                                       25

<210> 482
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 482
auuucucuga agucaaguuu gcacg                                       25

<210> 483
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 483
cauuugcccu caaccuacca acacu                                       25

<210> 484
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 484
aguguuggua gguugagggc aaaug                                       25

<210> 485
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 485
ucucaguuaa cuguguccca guuca                                       25

<210> 486
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 486
ugaacuggga cacaguuaac ugaga                                       25

<210> 487
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 487
gauuauguug aaacaguccu ggauu                                       25

<210> 488
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 488
aauccaggac uguuucaaca uaauc                                       25

<210> 489
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 489
gaaacagucc uggauuccac augca                                       25

<210> 490
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 490
ugcaugugga auccaggacu guuuc                                       25

<210> 491
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 491
cgaagauggu acguuagccu cuaag                                       25

<210> 492
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 492
cuuagaggcu aacguaccau cuucg                                       25

<210> 493
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 493
gaugguacgu uagccucuaa gacua                                       25

<210> 494
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 494
uagucuuaga ggcuaacgua ccauc                                       25

<210> 495
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 495
cagaaagaca agaaaggcau cucca                                       25

<210> 496
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 496
uggagaugcc uuucuugucu uucug                                       25

<210> 497
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 497
gaugaggaaa cucagaucaa aguua                                       25

<210> 498
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 498
uaacuuugau cugaguuucc ucauc                                       25

<210> 499
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 499
gaagaggcag cuucuggcuu gcuaa                                       25

<210> 500
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 500
uuagcaagcc agaagcugcc ucuuc                                       25

<210> 501
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 501
gcuugcuaac cucucugaaa gacaa                                       25

<210> 502
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 502
uugucuuuca gagagguuag caagc                                       25

<210> 503
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 503
cacccugaga gaagugucuu caaag                                       25

<210> 504
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 504
cuuugaagac acuucucuca gggug                                       25

<210> 505
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 505
gggccauuag gcaaauugau gauau                                       25

<210> 506
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 506
auaucaucaa uuugccuaau ggccc                                       25

<210> 507
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 507
ggaaggacaa ggcccagaau cugua                                       25

<210> 508
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 508
uacagauucu gggccuuguc cuucc                                       25

<210> 509
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 509
cccagaaucu guaccaggaa cuguu                                       25

<210> 510
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 510
aacaguuccu gguacagauu cuggg                                       25

<210> 511
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 511
ggauauacac uagggaggaa cuuug                                       25

<210> 512
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 512
caaaguuccu cccuagugua uaucc                                       25

<210> 513
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 513
cacuagggag gaacuuugca cuaug                                       25

<210> 514
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 514
cauagugcaa aguuccuccc uagug                                       25

<210> 515
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 515
gaggaacuuu gcacuauguu cauaa                                       25

<210> 516
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 516
uuaugaacau agugcaaagu uccuc                                       25

<210> 517
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 517
gguacugucc cagguauauu cgaaa                                       25

<210> 518
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 518
uuucgaauau accugggaca guacc                                       25

<210> 519
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 519
cgaaagucca uaaugguuca gaaau                                       25

<210> 520
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 520
auuucugaac cauuauggac uuucg                                       25

<210> 521
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 521
ccaagaccua gugauuacac uuccu                                       25

<210> 522
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 522
aggaagugua aucacuaggu cuugg                                       25

<210> 523
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 523
aagaccuagu gauuacacuu ccuuu                                       25

<210> 524
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 524
aaaggaagug uaaucacuag gucuu                                       25

<210> 525
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 525
uaaucucgau guauagggaa cuguu                                       25

<210> 526
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 526
aacaguuccc uauacaucga gauua                                       25

<210> 527
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 527
ucucgaugua uagggaacug uugaa                                       25

<210> 528
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 528
uucaacaguu cccuauacau cgaga                                       25

<210> 529
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 529
aaacgagcuu caggaagcuu cucaa                                       25

<210> 530
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 530
uugagaagcu uccugaagcu cguuu                                       25

<210> 531
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 531
gaucaagaac cuguuaguug cucuu                                       25

<210> 532
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 532
aagagcaacu aacagguucu ugauc                                       25

<210> 533
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 533
ucaagaaccu guuaguugcu cuuaa                                       25

<210> 534
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 534
uuaagagcaa cuaacagguu cuuga                                       25

<210> 535
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 535
caagaaccug uuaguugcuc uuaag                                       25

<210> 536
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 536
cuuaagagca acuaacaggu ucuug                                       25

<210> 537
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 537
cccaacucuc aagucaaguu gagca                                       25

<210> 538
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 538
ugcucaacuu gacuugagag uuggg                                       25

<210> 539
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 539
caagucaagu ugagcaauuu cugca                                       25

<210> 540
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 540
ugcagaaauu gcucaacuug acuug                                       25

<210> 541
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 541
aaguugagca auuucugcac agaaa                                       25

<210> 542
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 542
uuucugugca gaaauugcuc aacuu                                       25

<210> 543
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 543
accagcaguu uagauauaaa cugca                                       25

<210> 544
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 544
ugcaguuuau aucuaaacug cuggu                                       25

<210> 545
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 545
gaccaacucu cugauuacua ugaaa                                       25

<210> 546
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 546
uuucauagua aucagagagu ugguc                                       25

<210> 547
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 547
aagauugauu gaccugucca uucaa                                       25

<210> 548
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 548
uugaauggac aggucaauca aucuu                                       25

<210> 549
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 549
ugauauacau cacggaguua cugaa                                       25

<210> 550
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 550
uucaguaacu ccgugaugua uauca                                       25

<210> 551
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 551
ccaggagaac uuacuaucau ccucu                                       25

<210> 552
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 552
agaggaugau aguaaguucu ccugg                                       25

<210> 553
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 553
caggagaacu uacuaucauc cucua                                       25

<210> 554
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 554
uagaggauga uaguaaguuc uccug                                       25

<210> 555
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 555
ggagaacuua cuaucauccu cuaau                                       25

<210> 556
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 556
auuagaggau gauaguaagu ucucc                                       25

<210> 557
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 557
cagccuugca guaggcagua gacua                                       25

<210> 558
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 558
uagucuacug ccuacugcaa ggcug                                       25

<210> 559
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 559
gccuugcagu aggcaguaga cuaua                                       25

<210> 560
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 560
uauagucuac ugccuacugc aaggc                                       25

<210> 561
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 561
caguagacua uaagcagaag cacau                                       25

<210> 562
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 562
augugcuucu gcuuauaguc uacug                                       25

<210> 563
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 563
gacuauaagc agaagcacau augaa                                       25

<210> 564
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 564
uucauaugug cuucugcuua uaguc                                       25

<210> 565
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 565
gaagcacaua ugaacuggac cugca                                       25

<210> 566
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 566
ugcaggucca guucauaugu gcuuc                                       25

<210> 567
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 567
cauaugaacu ggaccugcac caaag                                       25

<210> 568
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Candidate Molecule for the inhibition of
      Apolipoprotein B

<400> 568
cuuuggugca gguccaguuc auaug                                       25

<210> 569
<211> 3636
<212> DNA
<213> Homo sapiens

<400> 569
cagcgacgtc gaggcgctca tggttgcagg cgggcgccgc cgttcagttc agggtctgag 60
cctggaggag tgagccaggc agtgagactg gctcgggcgg gccgggacgc gtcgttgcag 120
cagcggctcc cagctcccag ccaggattcc gcgcgcccct tcacgcgccc tgctcctgaa 180
cttcagctcc tgcacagtcc tccccaccgc aaggctcaag gcgccgccgg cgtggaccgc 240
gcacggcctc taggtctcct cgccaggaca gcaacctctc ccctggccct catgggcacc 300
gtcagctcca ggcggtcctg gtggccgctg ccactgctgc tgctgctgct gctgctcctg 360
ggtcccgcgg gcgcccgtgc gcaggaggac gaggacggcg actacgagga gctggtgcta 420
gccttgcgtt ccgaggagga cggcctggcc gaagcacccg agcacggaac cacagccacc 480
ttccaccgct gcgccaagga tccgtggagg ttgcctggca cctacgtggt ggtgctgaag 540
gaggagaccc acctctcgca gtcagagcgc actgcccgcc gcctgcaggc ccaggctgcc 600
cgccggggat acctcaccaa gatcctgcat gtcttccatg gccttcttcc tggcttcctg 660
gtgaagatga gtggcgacct gctggagctg gccttgaagt tgccccatgt cgactacatc 720
gaggaggact cctctgtctt tgcccagagc atcccgtgga acctggagcg gattacccct 780
ccacggtacc gggcggatga ataccagccc cccgacggag gcagcctggt ggaggtgtat 840
ctcctagaca ccagcataca gagtgaccac cgggaaatcg agggcagggt catggtcacc 900
gacttcgaga atgtgcccga ggaggacggg acccgcttcc acagacaggc cagcaagtgt 960
gacagtcatg gcacccacct ggcaggggtg gtcagcggcc gggatgccgg cgtggccaag 1020
ggtgccagca tgcgcagcct gcgcgtgctc aactgccaag ggaagggcac ggttagcggc 1080
accctcatag gcctggagtt tattcggaaa agccagctgg tccagcctgt ggggccactg 1140
gtggtgctgc tgcccctggc gggtgggtac agccgcgtcc tcaacgccgc ctgccagcgc 1200
ctggcgaggg ctggggtcgt gctggtcacc gctgccggca acttccggga cgatgcctgc 1260
ctctactccc cagcctcagc tcccgaggtc atcacagttg gggccaccaa tgcccaagac 1320
cagccggtga ccctggggac tttggggacc aactttggcc gctgtgtgga cctctttgcc 1380
ccaggggagg acatcattgg tgcctccagc gactgcagca cctgctttgt gtcacagagt 1440
gggacatcac aggctgctgc ccacgtggct ggcattgcag ccatgatgct gtctgccgag 1500
ccggagctca ccctggccga gttgaggcag agactgatcc acttctctgc caaagatgtc 1560
atcaatgagg cctggttccc tgaggaccag cgggtactga cccccaacct ggtggccgcc 1620
ctgcccccca gcacccatgg ggcaggttgg cagctgtttt gcaggactgt atggtcagca 1680
cactcggggc ctacacggat ggccacagcc gtcgcccgct gcgccccaga tgaggagctg 1740
ctgagctgct ccagtttctc caggagtggg aagcggcggg gcgagcgcat ggaggcccaa 1800
gggggcaagc tggtctgccg ggcccacaac gcttttgggg gtgagggtgt ctacgccatt 1860
gccaggtgct gcctgctacc ccaggccaac tgcagcgtcc acacagctcc accagctgag 1920
gccagcatgg ggacccgtgt ccactgccac caacagggcc acgtcctcac aggctgcagc 1980
tcccactggg aggtggagga ccttggcacc cacaagccgc ctgtgctgag gccacgaggt 2040
cagcccaacc agtgcgtggg ccacagggag gccagcatcc acgcttcctg ctgccatgcc 2100
ccaggtctgg aatgcaaagt caaggagcat ggaatcccgg cccctcagga gcaggtgacc 2160
gtggcctgcg aggagggctg gaccctgact ggctgcagtg ccctccctgg gacctcccac 2220
gtcctggggg cctacgccgt agacaacacg tgtgtagtca ggagccggga cgtcagcact 2280
acaggcagca ccagcgaagg ggccgtgaca gccgttgcca tctgctgccg gagccggcac 2340
ctggcgcagg cctcccagga gctccagtga cagccccatc ccaggatggg tgtctgggga 2400
gggtcaaggg ctggggctga gctttaaaat ggttccgact tgtccctctc tcagccctcc 2460
atggcctggc acgaggggat ggggatgctt ccgcctttcc ggggctgctg gcctggccct 2520
tgagtggggc agcctccttg cctggaactc actcactctg ggtgcctcct ccccaggtgg 2580
aggtgccagg aagctccctc cctcactgtg gggcatttca ccattcaaac aggtcgagct 2640
gtgctcgggt gctgccagct gctcccaatg tgccgatgtc cgtgggcaga atgactttta 2700
ttgagctctt gttccgtgcc aggcattcaa tcctcaggtc tccaccaagg aggcaggatt 2760
cttcccatgg ataggggagg gggcggtagg ggctgcaggg acaaacatcg ttggggggtg 2820
agtgtgaaag gtgctgatgg ccctcatctc cagctaactg tggagaagcc cctgggggct 2880
ccctgattaa tggaggctta gctttctgga tggcatctag ccagaggctg gagacaggtg 2940
cgcccctggt ggtcacaggc tgtgccttgg tttcctgagc cacctttact ctgctctatg 3000
ccaggctgtg ctagcaacac ccaaaggtgg cctgcgggga gccatcacct aggactgact 3060
cggcagtgtg cagtggtgca tgcactgtct cagccaaccc gctccactac ccggcagggt 3120
acacattcgc acccctactt cacagaggaa gaaacctgga accagagggg gcgtgcctgc 3180
caagctcaca cagcaggaac tgagccagaa acgcagattg ggctggctct gaagccaagc 3240
ctcttcttac ttcacccggc tgggctcctc atttttacgg gtaacagtga ggctgggaag 3300
gggaacacag accaggaagc tcggtgagtg atggcagaac gatgcctgca ggcatggaac 3360
tttttccgtt atcacccagg cctgattcac tggcctggcg gagatgcttc taaggcatgg 3420
tcgggggaga gggccaacaa ctgtccctcc ttgagcacca gccccaccca agcaagcaga 3480
catttatctt ttgggtctgt cctctctgtt gcctttttac agccaacttt tctagacctg 3540
ttttgctttt gtaacttgaa gatatttatt ctgggttttg tagcattttt attaatatgg 3600
tgacttttta aaataaaaac aaacaaacgt tgtcct                           3636

<210> 570
<211> 14121
<212> DNA
<213> Homo sapiens

<400> 570
attcccaccg ggacctgcgg ggctgagtgc ccttctcggt tgctgccgct gaggagcccg 60
cccagccagc cagggccgcg aggccgaggc caggccgcag cccaggagcc gccccaccgc 120
agctggcgat ggacccgccg aggcccgcgc tgctggcgct gctggcgctg cctgcgctgc 180
tgctgctgct gctggcgggc gccagggccg aagaggaaat gctggaaaat gtcagcctgg 240
tctgtccaaa agatgcgacc cgattcaagc acctccggaa gtacacatac aactatgagg 300
ctgagagttc cagtggagtc cctgggactg ctgattcaag aagtgccacc aggatcaact 360
gcaaggttga gctggaggtt ccccagctct gcagcttcat cctgaagacc agccagtgca 420
ccctgaaaga ggtgtatggc ttcaaccctg agggcaaagc cttgctgaag aaaaccaaga 480
actctgagga gtttgctgca gccatgtcca ggtatgagct caagctggcc attccagaag 540
ggaagcaggt tttcctttac ccggagaaag atgaacctac ttacatcctg aacatcaaga 600
ggggcatcat ttctgccctc ctggttcccc cagagacaga agaagccaag caagtgttgt 660
ttctggatac cgtgtatgga aactgctcca ctcactttac cgtcaagacg aggaagggca 720
atgtggcaac agaaatatcc actgaaagag acctggggca gtgtgatcgc ttcaagccca 780
tccgcacagg catcagccca cttgctctca tcaaaggcat gacccgcccc ttgtcaactc 840
tgatcagcag cagccagtcc tgtcagtaca cactggacgc taagaggaag catgtggcag 900
aagccatctg caaggagcaa cacctcttcc tgcctttctc ctacaagaat aagtatggga 960
tggtagcaca agtgacacag actttgaaac ttgaagacac accaaagatc aacagccgct 1020
tctttggtga aggtactaag aagatgggcc tcgcatttga gagcaccaaa tccacatcac 1080
ctccaaagca ggccgaagct gttttgaaga ctctccagga actgaaaaaa ctaaccatct 1140
ctgagcaaaa tatccagaga gctaatctct tcaataagct ggttactgag ctgagaggcc 1200
tcagtgatga agcagtcaca tctctcttgc cacagctgat tgaggtgtcc agccccatca 1260
ctttacaagc cttggttcag tgtggacagc ctcagtgctc cactcacatc ctccagtggc 1320
tgaaacgtgt gcatgccaac ccccttctga tagatgtggt cacctacctg gtggccctga 1380
tccccgagcc ctcagcacag cagctgcgag agatcttcaa catggcgagg gatcagcgca 1440
gccgagccac cttgtatgcg ctgagccacg cggtcaacaa ctatcataag acaaacccta 1500
cagggaccca ggagctgctg gacattgcta attacctgat ggaacagatt caagatgact 1560
gcactgggga tgaagattac acctatttga ttctgcgggt cattggaaat atgggccaaa 1620
ccatggagca gttaactcca gaactcaagt cttcaatcct gaaatgtgtc caaagtacaa 1680
agccatcact gatgatccag aaagctgcca tccaggctct gcggaaaatg gagcctaaag 1740
acaaggacca ggaggttctt cttcagactt tccttgatga tgcttctccg ggagataagc 1800
gactggctgc ctatcttatg ttgatgagga gtccttcaca ggcagatatt aacaaaattg 1860
tccaaattct accatgggaa cagaatgagc aagtgaagaa ctttgtggct tcccatattg 1920
ccaatatctt gaactcagaa gaattggata tccaagatct gaaaaagtta gtgaaagaag 1980
ctctgaaaga atctcaactt ccaactgtca tggacttcag aaaattctct cggaactatc 2040
aactctacaa atctgtttct cttccatcac ttgacccagc ctcagccaaa atagaaggga 2100
atcttatatt tgatccaaat aactaccttc ctaaagaaag catgctgaaa actaccctca 2160
ctgcctttgg atttgcttca gctgacctca tcgagattgg cttggaagga aaaggctttg 2220
agccaacatt ggaagctctt tttgggaagc aaggattttt cccagacagt gtcaacaaag 2280
ctttgtactg ggttaatggt caagttcctg atggtgtctc taaggtctta gtggaccact 2340
ttggctatac caaagatgat aaacatgagc aggatatggt aaatggaata atgctcagtg 2400
ttgagaagct gattaaagat ttgaaatcca aagaagtccc ggaagccaga gcctacctcc 2460
gcatcttggg agaggagctt ggttttgcca gtctccatga cctccagctc ctgggaaagc 2520
tgcttctgat gggtgcccgc actctgcagg ggatccccca gatgattgga gaggtcatca 2580
ggaagggctc aaagaatgac ttttttcttc actacatctt catggagaat gcctttgaac 2640
tccccactgg agctggatta cagttgcaaa tatcttcatc tggagtcatt gctcccggag 2700
ccaaggctgg agtaaaactg gaagtagcca acatgcaggc tgaactggtg gcaaaaccct 2760
ccgtgtctgt ggagtttgtg acaaatatgg gcatcatcat tccggacttc gctaggagtg 2820
gggtccagat gaacaccaac ttcttccacg agtcgggtct ggaggctcat gttgccctaa 2880
aagctgggaa gctgaagttt atcattcctt ccccaaagag accagtcaag ctgctcagtg 2940
gaggcaacac attacatttg gtctctacca ccaaaacgga ggtgatccca cctctcattg 3000
agaacaggca gtcctggtca gtttgcaagc aagtctttcc tggcctgaat tactgcacct 3060
caggcgctta ctccaacgcc agctccacag actccgcctc ctactatccg ctgaccgggg 3120
acaccagatt agagctggaa ctgaggccta caggagagat tgagcagtat tctgtcagcg 3180
caacctatga gctccagaga gaggacagag ccttggtgga taccctgaag tttgtaactc 3240
aagcagaagg tgcgaagcag actgaggcta ccatgacatt caaatataat cggcagagta 3300
tgaccttgtc cagtgaagtc caaattccgg attttgatgt tgacctcgga acaatcctca 3360
gagttaatga tgaatctact gagggcaaaa cgtcttacag actcaccctg gacattcaga 3420
acaagaaaat tactgaggtc gccctcatgg gccacctaag ttgtgacaca aaggaagaaa 3480
gaaaaatcaa gggtgttatt tccatacccc gtttgcaagc agaagccaga agtgagatcc 3540
tcgcccactg gtcgcctgcc aaactgcttc tccaaatgga ctcatctgct acagcttatg 3600
gctccacagt ttccaagagg gtggcatggc attatgatga agagaagatt gaatttgaat 3660
ggaacacagg caccaatgta gataccaaaa aaatgacttc caatttccct gtggatctct 3720
ccgattatcc taagagcttg catatgtatg ctaatagact cctggatcac agagtccctc 3780
aaacagacat gactttccgg cacgtgggtt ccaaattaat agttgcaatg agctcatggc 3840
ttcagaaggc atctgggagt cttccttata cccagacttt gcaagaccac ctcaatagcc 3900
tgaaggagtt caacctccag aacatgggat tgccagactt ccacatccca gaaaacctct 3960
tcttaaaaag cgatggccgg gtcaaatata ccttgaacaa gaacagtttg aaaattgaga 4020
ttcctttgcc ttttggtggc aaatcctcca gagatctaaa gatgttagag actgttagga 4080
caccagccct ccacttcaag tctgtgggat tccatctgcc atctcgagag ttccaagtcc 4140
ctacttttac cattcccaag ttgtatcaac tgcaagtgcc tctcctgggt gttctagacc 4200
tctccacgaa tgtctacagc aacttgtaca actggtccgc ctcctacagt ggtggcaaca 4260
ccagcacaga ccatttcagc cttcgggctc gttaccacat gaaggctgac tctgtggttg 4320
acctgctttc ctacaatgtg caaggatctg gagaaacaac atatgaccac aagaatacgt 4380
tcacactatc atgtgatggg tctctacgcc acaaatttct agattcgaat atcaaattca 4440
gtcatgtaga aaaacttgga aacaacccag tctcaaaagg tttactaata ttcgatgcat 4500
ctagttcctg gggaccacag atgtctgctt cagttcattt ggactccaaa aagaaacagc 4560
atttgtttgt caaagaagtc aagattgatg ggcagttcag agtctcttcg ttctatgcta 4620
aaggcacata tggcctgtct tgtcagaggg atcctaacac tggccggctc aatggagagt 4680
ccaacctgag gtttaactcc tcctacctcc aaggcaccaa ccagataaca ggaagatatg 4740
aagatggaac cctctccctc acctccacct ctgatctgca aagtggcatc attaaaaata 4800
ctgcttccct aaagtatgag aactacgagc tgactttaaa atctgacacc aatgggaagt 4860
ataagaactt tgccacttct aacaagatgg atatgacctt ctctaagcaa aatgcactgc 4920
tgcgttctga atatcaggct gattacgagt cattgaggtt cttcagcctg ctttctggat 4980
cactaaattc ccatggtctt gagttaaatg ctgacatctt aggcactgac aaaattaata 5040
gtggtgctca caaggcgaca ctaaggattg gccaagatgg aatatctacc agtgcaacga 5100
ccaacttgaa gtgtagtctc ctggtgctgg agaatgagct gaatgcagag cttggcctct 5160
ctggggcatc tatgaaatta acaacaaatg gccgcttcag ggaacacaat gcaaaattca 5220
gtctggatgg gaaagccgcc ctcacagagc tatcactggg aagtgcttat caggccatga 5280
ttctgggtgt cgacagcaaa aacattttca acttcaaggt cagtcaagaa ggacttaagc 5340
tctcaaatga catgatgggc tcatatgctg aaatgaaatt tgaccacaca aacagtctga 5400
acattgcagg cttatcactg gacttctctt caaaacttga caacatttac agctctgaca 5460
agttttataa gcaaactgtt aatttacagc tacagcccta ttctctggta actactttaa 5520
acagtgacct gaaatacaat gctctggatc tcaccaacaa tgggaaacta cggctagaac 5580
ccctgaagct gcatgtggct ggtaacctaa aaggagccta ccaaaataat gaaataaaac 5640
acatctatgc catctcttct gctgccttat cagcaagcta taaagcagac actgttgcta 5700
aggttcaggg tgtggagttt agccatcggc tcaacacaga catcgctggg ctggcttcag 5760
ccattgacat gagcacaaac tataattcag actcactgca tttcagcaat gtcttccgtt 5820
ctgtaatggc cccgtttacc atgaccatcg atgcacatac aaatggcaat gggaaactcg 5880
ctctctgggg agaacatact gggcagctgt atagcaaatt cctgttgaaa gcagaacctc 5940
tggcatttac tttctctcat gattacaaag gctccacaag tcatcatctc gtgtctagga 6000
aaagcatcag tgcagctctt gaacacaaag tcagtgccct gcttactcca gctgagcaga 6060
caggcacctg gaaactcaag acccaattta acaacaatga atacagccag gacttggatg 6120
cttacaacac taaagataaa attggcgtgg agcttactgg acgaactctg gctgacctaa 6180
ctctactaga ctccccaatt aaagtgccac ttttactcag tgagcccatc aatatcattg 6240
atgctttaga gatgagagat gccgttgaga agccccaaga atttacaatt gttgcttttg 6300
taaagtatga taaaaaccaa gatgttcact ccattaacct cccatttttt gagaccttgc 6360
aagaatattt tgagaggaat cgacaaacca ttatagttgt actggaaaac gtacagagaa 6420
acctgaagca catcaatatt gatcaatttg taagaaaata cagagcagcc ctgggaaaac 6480
tcccacagca agctaatgat tatctgaatt cattcaattg ggagagacaa gtttcacatg 6540
ccaaggagaa actgactgct ctcacaaaaa agtatagaat tacagaaaat gatatacaaa 6600
ttgcattaga tgatgccaaa atcaacttta atgaaaaact atctcaactg cagacatata 6660
tgatacaatt tgatcagtat attaaagata gttatgattt acatgatttg aaaatagcta 6720
ttgctaatat tattgatgaa atcattgaaa aattaaaaag tcttgatgag cactatcata 6780
tccgtgtaaa tttagtaaaa acaatccatg atctacattt gtttattgaa aatattgatt 6840
ttaacaaaag tggaagtagt actgcatcct ggattcaaaa tgtggatact aagtaccaaa 6900
tcagaatcca gatacaagaa aaactgcagc agcttaagag acacatacag aatatagaca 6960
tccagcacct agctggaaag ttaaaacaac acattgaggc tattgatgtt agagtgcttt 7020
tagatcaatt gggaactaca atttcatttg aaagaataaa tgacgttctt gagcatgtca 7080
aacactttgt tataaatctt attggggatt ttgaagtagc tgagaaaatc aatgccttca 7140
gagccaaagt ccatgagtta atcgagaggt atgaagtaga ccaacaaatc caggttttaa 7200
tggataaatt agtagagttg gcccaccaat acaagttgaa ggagactatt cagaagctaa 7260
gcaatgtcct acaacaagtt aagataaaag attactttga gaaattggtt ggatttattg 7320
atgatgctgt caagaagctt aatgaattat cttttaaaac attcattgaa gatgttaaca 7380
aattccttga catgttgata aagaaattaa agtcatttga ttaccaccag tttgtagatg 7440
aaaccaatga caaaatccgt gaggtgactc agagactcaa tggtgaaatt caggctctgg 7500
aactaccaca aaaagctgaa gcattaaaac tgtttttaga ggaaaccaag gccacagttg 7560
cagtgtatct ggaaagccta caggacacca aaataacctt aatcatcaat tggttacagg 7620
aggctttaag ttcagcatct ttggctcaca tgaaggccaa attccgagag accctagaag 7680
atacacgaga ccgaatgtat caaatggaca ttcagcagga acttcaacga tacctgtctc 7740
tggtaggcca ggtttatagc acacttgtca cctacatttc tgattggtgg actcttgctg 7800
ctaagaacct tactgacttt gcagagcaat attctatcca agattgggct aaacgtatga 7860
aagcattggt agagcaaggg ttcactgttc ctgaaatcaa gaccatcctt gggaccatgc 7920
ctgcctttga agtcagtctt caggctcttc agaaagctac cttccagaca cctgatttta 7980
tagtccccct aacagatttg aggattccat cagttcagat aaacttcaaa gacttaaaaa 8040
atataaaaat cccatccagg ttttccacac cagaatttac catccttaac accttccaca 8100
ttccttcctt tacaattgac tttgtagaaa tgaaagtaaa gatcatcaga accattgacc 8160
agatgctgaa cagtgagctg cagtggcccg ttccagatat atatctcagg gatctgaagg 8220
tggaggacat tcctctagcg agaatcaccc tgccagactt ccgtttacca gaaatcgcaa 8280
ttccagaatt cataatccca actctcaacc ttaatgattt tcaagttcct gaccttcaca 8340
taccagaatt ccagcttccc cacatctcac acacaattga agtacctact tttggcaagc 8400
tatacagtat tctgaaaatc caatctcctc ttttcacatt agatgcaaat gctgacatag 8460
ggaatggaac cacctcagca aacgaagcag gtatcgcagc ttccatcact gccaaaggag 8520
agtccaaatt agaagttctc aattttgatt ttcaagcaaa tgcacaactc tcaaacccta 8580
agattaatcc gctggctctg aaggagtcag tgaagttctc cagcaagtac ctgagaacgg 8640
agcatgggag tgaaatgctg ttttttggaa atgctattga gggaaaatca aacacagtgg 8700
caagtttaca cacagaaaaa aatacactgg agcttagtaa tggagtgatt gtcaagataa 8760
acaatcagct taccctggat agcaacacta aatacttcca caaattgaac atccccaaac 8820
tggacttctc tagtcaggct gacctgcgca acgagatcaa gacactgttg aaagctggcc 8880
acatagcatg gacttcttct ggaaaagggt catggaaatg ggcctgcccc agattctcag 8940
atgagggaac acatgaatca caaattagtt tcaccataga aggacccctc acttcctttg 9000
gactgtccaa taagatcaat agcaaacacc taagagtaaa ccaaaacttg gtttatgaat 9060
ctggctccct caacttttct aaacttgaaa ttcaatcaca agtcgattcc cagcatgtgg 9120
gccacagtgt tctaactgct aaaggcatgg cactgtttgg agaagggaag gcagagttta 9180
ctgggaggca tgatgctcat ttaaatggaa aggttattgg aactttgaaa aattctcttt 9240
tcttttcagc ccagccattt gagatcacgg catccacaaa caatgaaggg aatttgaaag 9300
ttcgttttcc attaaggtta acagggaaga tagacttcct gaataactat gcactgtttc 9360
tgagtcccag tgcccagcaa gcaagttggc aagtaagtgc taggttcaat cagtataagt 9420
acaaccaaaa tttctctgct ggaaacaacg agaacattat ggaggcccat gtaggaataa 9480
atggagaagc aaatctggat ttcttaaaca ttcctttaac aattcctgaa atgcgtctac 9540
cttacacaat aatcacaact cctccactga aagatttctc tctatgggaa aaaacaggct 9600
tgaaggaatt cttgaaaacg acaaagcaat catttgattt aagtgtaaaa gctcagtata 9660
agaaaaacaa acacaggcat tccatcacaa atcctttggc tgtgctttgt gagtttatca 9720
gtcagagcat caaatccttt gacaggcatt ttgaaaaaaa cagaaacaat gcattagatt 9780
ttgtcaccaa atcctataat gaaacaaaaa ttaagtttga taagtacaaa gctgaaaaat 9840
ctcacgacga gctccccagg acctttcaaa ttcctggata cactgttcca gttgtcaatg 9900
ttgaagtgtc tccattcacc atagagatgt cggcattcgg ctatgtgttc ccaaaagcag 9960
tcagcatgcc tagtttctcc atcctaggtt ctgacgtccg tgtgccttca tacacattaa 10020
tcctgccatc attagagctg ccagtccttc atgtccctag aaatctcaag ctttctcttc 10080
cagatttcaa ggaattgtgt accataagcc atatttttat tcctgccatg ggcaatatta 10140
cctatgattt ctcctttaaa tcaagtgtca tcacactgaa taccaatgct gaacttttta 10200
accagtcaga tattgttgct catctccttt cttcatcttc atctgtcatt gatgcactgc 10260
agtacaaatt agagggcacc acaagattga caagaaaaag gggattgaag ttagccacag 10320
ctctgtctct gagcaacaaa tttgtggagg gtagtcataa cagtactgtg agcttaacca 10380
cgaaaaatat ggaagtgtca gtggcaacaa ccacaaaagc ccaaattcca attttgagaa 10440
tgaatttcaa gcaagaactt aatggaaata ccaagtcaaa acctactgtc tcttcctcca 10500
tggaatttaa gtatgatttc aattcttcaa tgctgtactc taccgctaaa ggagcagttg 10560
accacaagct tagcttggaa agcctcacct cttacttttc cattgagtca tctaccaaag 10620
gagatgtcaa gggttcggtt ctttctcggg aatattcagg aactattgct agtgaggcca 10680
acacttactt gaattccaag agcacacggt cttcagtgaa gctgcagggc acttccaaaa 10740
ttgatgatat ctggaacctt gaagtaaaag aaaattttgc tggagaagcc acactccaac 10800
gcatatattc cctctgggag cacagtacga aaaaccactt acagctagag ggcctctttt 10860
tcaccaacgg agaacataca agcaaagcca ccctggaact ctctccatgg caaatgtcag 10920
ctcttgttca ggtccatgca agtcagccca gttccttcca tgatttccct gaccttggcc 10980
aggaagtggc cctgaatgct aacactaaga accagaagat cagatggaaa aatgaagtcc 11040
ggattcattc tgggtctttc cagagccagg tcgagctttc caatgaccaa gaaaaggcac 11100
accttgacat tgcaggatcc ttagaaggac acctaaggtt cctcaaaaat atcatcctac 11160
cagtctatga caagagctta tgggatttcc taaagctgga tgtaaccacc agcattggta 11220
ggagacagca tcttcgtgtt tcaactgcct ttgtgtacac caaaaacccc aatggctatt 11280
cattctccat ccctgtaaaa gttttggctg ataaattcat tattcctggg ctgaaactaa 11340
atgatctaaa ttcagttctt gtcatgccta cgttccatgt cccatttaca gatcttcagg 11400
ttccatcgtg caaacttgac ttcagagaaa tacaaatcta taagaagctg agaacttcat 11460
catttgccct caacctacca acactccccg aggtaaaatt ccctgaagtt gatgtgttaa 11520
caaaatattc tcaaccagaa gactccttga ttcccttttt tgagataacc gtgcctgaat 11580
ctcagttaac tgtgtcccag ttcacgcttc caaaaagtgt ttcagatggc attgctgctt 11640
tggatctaaa tgcagtagcc aacaagatcg cagactttga gttgcccacc atcatcgtgc 11700
ctgagcagac cattgagatt ccctccatta agttctctgt acctgctgga attgtcattc 11760
cttcctttca agcactgact gcacgctttg aggtagactc tcccgtgtat aatgccactt 11820
ggagtgccag tttgaaaaac aaagcagatt atgttgaaac agtcctggat tccacatgca 11880
gctcaaccgt acagttccta gaatatgaac taaatgtttt gggaacacac aaaatcgaag 11940
atggtacgtt agcctctaag actaaaggaa catttgcaca ccgtgacttc agtgcagaat 12000
atgaagaaga tggcaaatat gaaggacttc aggaatggga aggaaaagcg cacctcaata 12060
tcaaaagccc agcgttcacc gatctccatc tgcgctacca gaaagacaag aaaggcatct 12120
ccacctcagc agcctcccca gccgtaggca ccgtgggcat ggatatggat gaagatgacg 12180
acttttctaa atggaacttc tactacagcc ctcagtcctc tccagataaa aaactcacca 12240
tattcaaaac tgagttgagg gtccgggaat ctgatgagga aactcagatc aaagttaatt 12300
gggaagaaga ggcagcttct ggcttgctaa cctctctgaa agacaacgtg cccaaggcca 12360
caggggtcct ttatgattat gtcaacaagt accactggga acacacaggg ctcaccctga 12420
gagaagtgtc ttcaaagctg agaagaaatc tgcagaacaa tgctgagtgg gtttatcaag 12480
gggccattag gcaaattgat gatatcgacg tgaggttcca gaaagcagcc agtggcacca 12540
ctgggaccta ccaagagtgg aaggacaagg cccagaatct gtaccaggaa ctgttgactc 12600
aggaaggcca agccagtttc cagggactca aggataacgt gtttgatggc ttggtacgag 12660
ttactcaaga attccatatg aaagtcaagc atctgattga ctcactcatt gattttctga 12720
acttccccag attccagttt ccggggaaac ctgggatata cactagggag gaactttgca 12780
ctatgttcat aagggaggta gggacggtac tgtcccaggt atattcgaaa gtccataatg 12840
gttcagaaat actgttttcc tatttccaag acctagtgat tacacttcct ttcgagttaa 12900
ggaaacataa actaatagat gtaatctcga tgtataggga actgttgaaa gatttatcaa 12960
aagaagccca agaggtattt aaagccattc agtctctcaa gaccacagag gtgctacgta 13020
atcttcagga ccttttacaa ttcattttcc aactaataga agataacatt aaacagctga 13080
aagagatgaa atttacttat cttattaatt atatccaaga tgagatcaac acaatcttca 13140
gtgattatat cccatatgtt tttaaattgt tgaaagaaaa cctatgcctt aatcttcata 13200
agttcaatga atttattcaa aacgagcttc aggaagcttc tcaagagtta cagcagatcc 13260
atcaatacat tatggccctt cgtgaagaat attttgatcc aagtatagtt ggctggacag 13320
tgaaatatta tgaacttgaa gaaaagatag tcagtctgat caagaacctg ttagttgctc 13380
ttaaggactt ccattctgaa tatattgtca gtgcctctaa ctttacttcc caactctcaa 13440
gtcaagttga gcaatttctg cacagaaata ttcaggaata tcttagcatc cttaccgatc 13500
cagatggaaa agggaaagag aagattgcag agctttctgc cactgctcag gaaataatta 13560
aaagccaggc cattgcgacg aagaaaataa tttctgatta ccaccagcag tttagatata 13620
aactgcaaga tttttcagac caactctctg attactatga aaaatttatt gctgaatcca 13680
aaagattgat tgacctgtcc attcaaaact accacacatt tctgatatac atcacggagt 13740
tactgaaaaa gctgcaatca accacagtca tgaaccccta catgaagctt gctccaggag 13800
aacttactat catcctctaa ttttttaaaa gaaatcttca tttattcttc ttttccaatt 13860
gaactttcac atagcacaga aaaaattcaa actgcctata ttgataaaac catacagtga 13920
gccagccttg cagtaggcag tagactataa gcagaagcac atatgaactg gacctgcacc 13980
aaagctggca ccagggctcg gaaggtctct gaactcagaa ggatggcatt ttttgcaagt 14040
taaagaaaat caggatctga gttattttgc taaacttggg ggaggaggaa caaataaatg 14100
gagtctttat tgtgtatcat a                                           14121



<210> 571
<211> 692
<212> PRT
<213> Homo sapiens

<400> 571
Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu
            20                  25                  30          
Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu
        35                  40                  45              
Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe
    50                  55                  60                  
His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val
65                  70                  75                  80  
Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg
                85                  90                  95      
Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu
            100                 105                 110         
His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly
        115                 120                 125             
Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu
    130                 135                 140                 
Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg
145                 150                 155                 160 
Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly
                165                 170                 175     
Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp
            180                 185                 190         
His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val
        195                 200                 205             
Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp
    210                 215                 220                 
Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly
225                 230                 235                 240 
Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln
                245                 250                 255     
Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg
            260                 265                 270         
Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro
        275                 280                 285             
Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu
    290                 295                 300                 
Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp
305                 310                 315                 320 
Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val
                325                 330                 335     
Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly
            340                 345                 350         
Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile
        355                 360                 365             
Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly
    370                 375                 380                 
Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu
385                 390                 395                 400 
Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile
                405                 410                 415     
His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp
            420                 425                 430         
Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr
        435                 440                 445             
His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His
    450                 455                 460                 
Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp
465                 470                 475                 480 
Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg
                485                 490                 495     
Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His
            500                 505                 510         
Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu
        515                 520                 525             
Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala
    530                 535                 540                 
Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr
545                 550                 555                 560 
Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro
                565                 570                 575     
Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg
            580                 585                 590         
Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys
        595                 600                 605             
Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val
    610                 615                 620                 
Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly
625                 630                 635                 640 
Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val
                645                 650                 655     
Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val
            660                 665                 670         
Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser
        675                 680                 685             
Gln Glu Leu Gln
    690         


<210> 572
<211> 4563
<212> PRT
<213> Homo sapiens

<400> 572
Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala Glu Glu Glu Met Leu
            20                  25                  30          
Glu Asn Val Ser Leu Val Cys Pro Lys Asp Ala Thr Arg Phe Lys His
        35                  40                  45              
Leu Arg Lys Tyr Thr Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val
    50                  55                  60                  
Pro Gly Thr Ala Asp Ser Arg Ser Ala Thr Arg Ile Asn Cys Lys Val
65                  70                  75                  80  
Glu Leu Glu Val Pro Gln Leu Cys Ser Phe Ile Leu Lys Thr Ser Gln
                85                  90                  95      
Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala Leu
            100                 105                 110         
Leu Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala Met Ser Arg
        115                 120                 125             
Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys Gln Val Phe Leu Tyr
    130                 135                 140                 
Pro Glu Lys Asp Glu Pro Thr Tyr Ile Leu Asn Ile Lys Arg Gly Ile
145                 150                 155                 160 
Ile Ser Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Ala Lys Gln Val
                165                 170                 175     
Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val
            180                 185                 190         
Lys Thr Arg Lys Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp
        195                 200                 205             
Leu Gly Gln Cys Asp Arg Phe Lys Pro Ile Arg Thr Gly Ile Ser Pro
    210                 215                 220                 
Leu Ala Leu Ile Lys Gly Met Thr Arg Pro Leu Ser Thr Leu Ile Ser
225                 230                 235                 240 
Ser Ser Gln Ser Cys Gln Tyr Thr Leu Asp Ala Lys Arg Lys His Val
                245                 250                 255     
Ala Glu Ala Ile Cys Lys Glu Gln His Leu Phe Leu Pro Phe Ser Tyr
            260                 265                 270         
Lys Asn Lys Tyr Gly Met Val Ala Gln Val Thr Gln Thr Leu Lys Leu
        275                 280                 285             
Glu Asp Thr Pro Lys Ile Asn Ser Arg Phe Phe Gly Glu Gly Thr Lys
    290                 295                 300                 
Lys Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro Pro Lys
305                 310                 315                 320 
Gln Ala Glu Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Thr
                325                 330                 335     
Ile Ser Glu Gln Asn Ile Gln Arg Ala Asn Leu Phe Asn Lys Leu Val
            340                 345                 350         
Thr Glu Leu Arg Gly Leu Ser Asp Glu Ala Val Thr Ser Leu Leu Pro
        355                 360                 365             
Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln Ala Leu Val Gln
    370                 375                 380                 
Cys Gly Gln Pro Gln Cys Ser Thr His Ile Leu Gln Trp Leu Lys Arg
385                 390                 395                 400 
Val His Ala Asn Pro Leu Leu Ile Asp Val Val Thr Tyr Leu Val Ala
                405                 410                 415     
Leu Ile Pro Glu Pro Ser Ala Gln Gln Leu Arg Glu Ile Phe Asn Met
            420                 425                 430         
Ala Arg Asp Gln Arg Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala
        435                 440                 445             
Val Asn Asn Tyr His Lys Thr Asn Pro Thr Gly Thr Gln Glu Leu Leu
    450                 455                 460                 
Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys Thr Gly
465                 470                 475                 480 
Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly Asn Met Gly
                485                 490                 495     
Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys Ser Ser Ile Leu Lys
            500                 505                 510         
Cys Val Gln Ser Thr Lys Pro Ser Leu Met Ile Gln Lys Ala Ala Ile
        515                 520                 525             
Gln Ala Leu Arg Lys Met Glu Pro Lys Asp Lys Asp Gln Glu Val Leu
    530                 535                 540                 
Leu Gln Thr Phe Leu Asp Asp Ala Ser Pro Gly Asp Lys Arg Leu Ala
545                 550                 555                 560 
Ala Tyr Leu Met Leu Met Arg Ser Pro Ser Gln Ala Asp Ile Asn Lys
                565                 570                 575     
Ile Val Gln Ile Leu Pro Trp Glu Gln Asn Glu Gln Val Lys Asn Phe
            580                 585                 590         
Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Asp Ile
        595                 600                 605             
Gln Asp Leu Lys Lys Leu Val Lys Glu Ala Leu Lys Glu Ser Gln Leu
    610                 615                 620                 
Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Leu Tyr
625                 630                 635                 640 
Lys Ser Val Ser Leu Pro Ser Leu Asp Pro Ala Ser Ala Lys Ile Glu
                645                 650                 655     
Gly Asn Leu Ile Phe Asp Pro Asn Asn Tyr Leu Pro Lys Glu Ser Met
            660                 665                 670         
Leu Lys Thr Thr Leu Thr Ala Phe Gly Phe Ala Ser Ala Asp Leu Ile
        675                 680                 685             
Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu
    690                 695                 700                 
Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr
705                 710                 715                 720 
Trp Val Asn Gly Gln Val Pro Asp Gly Val Ser Lys Val Leu Val Asp
                725                 730                 735     
His Phe Gly Tyr Thr Lys Asp Asp Lys His Glu Gln Asp Met Val Asn
            740                 745                 750         
Gly Ile Met Leu Ser Val Glu Lys Leu Ile Lys Asp Leu Lys Ser Lys
        755                 760                 765             
Glu Val Pro Glu Ala Arg Ala Tyr Leu Arg Ile Leu Gly Glu Glu Leu
    770                 775                 780                 
Gly Phe Ala Ser Leu His Asp Leu Gln Leu Leu Gly Lys Leu Leu Leu
785                 790                 795                 800 
Met Gly Ala Arg Thr Leu Gln Gly Ile Pro Gln Met Ile Gly Glu Val
                805                 810                 815     
Ile Arg Lys Gly Ser Lys Asn Asp Phe Phe Leu His Tyr Ile Phe Met
            820                 825                 830         
Glu Asn Ala Phe Glu Leu Pro Thr Gly Ala Gly Leu Gln Leu Gln Ile
        835                 840                 845             
Ser Ser Ser Gly Val Ile Ala Pro Gly Ala Lys Ala Gly Val Lys Leu
    850                 855                 860                 
Glu Val Ala Asn Met Gln Ala Glu Leu Val Ala Lys Pro Ser Val Ser
865                 870                 875                 880 
Val Glu Phe Val Thr Asn Met Gly Ile Ile Ile Pro Asp Phe Ala Arg
                885                 890                 895     
Ser Gly Val Gln Met Asn Thr Asn Phe Phe His Glu Ser Gly Leu Glu
            900                 905                 910         
Ala His Val Ala Leu Lys Ala Gly Lys Leu Lys Phe Ile Ile Pro Ser
        915                 920                 925             
Pro Lys Arg Pro Val Lys Leu Leu Ser Gly Gly Asn Thr Leu His Leu
    930                 935                 940                 
Val Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Ile Glu Asn Arg
945                 950                 955                 960 
Gln Ser Trp Ser Val Cys Lys Gln Val Phe Pro Gly Leu Asn Tyr Cys
                965                 970                 975     
Thr Ser Gly Ala Tyr Ser Asn Ala Ser Ser Thr Asp Ser Ala Ser Tyr
            980                 985                 990         
Tyr Pro Leu Thr Gly Asp Thr Arg Leu Glu Leu Glu Leu Arg Pro Thr
        995                 1000                1005            
Gly Glu Ile Glu Gln Tyr Ser Val Ser Ala Thr Tyr Glu Leu Gln Arg
    1010                1015                1020                
Glu Asp Arg Ala Leu Val Asp Thr Leu Lys Phe Val Thr Gln Ala Glu
1025                1030                1035               1040 
Gly Ala Lys Gln Thr Glu Ala Thr Met Thr Phe Lys Tyr Asn Arg Gln
                1045                1050                1055    
Ser Met Thr Leu Ser Ser Glu Val Gln Ile Pro Asp Phe Asp Val Asp
            1060                1065                1070        
Leu Gly Thr Ile Leu Arg Val Asn Asp Glu Ser Thr Glu Gly Lys Thr
        1075                1080                1085            
Ser Tyr Arg Leu Thr Leu Asp Ile Gln Asn Lys Lys Ile Thr Glu Val
    1090                1095                1100                
Ala Leu Met Gly His Leu Ser Cys Asp Thr Lys Glu Glu Arg Lys Ile
1105                1110                1115               1120 
Lys Gly Val Ile Ser Ile Pro Arg Leu Gln Ala Glu Ala Arg Ser Glu
                1125                1130                1135    
Ile Leu Ala His Trp Ser Pro Ala Lys Leu Leu Leu Gln Met Asp Ser
            1140                1145                1150        
Ser Ala Thr Ala Tyr Gly Ser Thr Val Ser Lys Arg Val Ala Trp His
        1155                1160                1165            
Tyr Asp Glu Glu Lys Ile Glu Phe Glu Trp Asn Thr Gly Thr Asn Val
    1170                1175                1180                
Asp Thr Lys Lys Met Thr Ser Asn Phe Pro Val Asp Leu Ser Asp Tyr
1185                1190                1195               1200 
Pro Lys Ser Leu His Met Tyr Ala Asn Arg Leu Leu Asp His Arg Val
                1205                1210                1215    
Pro Gln Thr Asp Met Thr Phe Arg His Val Gly Ser Lys Leu Ile Val
            1220                1225                1230        
Ala Met Ser Ser Trp Leu Gln Lys Ala Ser Gly Ser Leu Pro Tyr Thr
        1235                1240                1245            
Gln Thr Leu Gln Asp His Leu Asn Ser Leu Lys Glu Phe Asn Leu Gln
    1250                1255                1260                
Asn Met Gly Leu Pro Asp Phe His Ile Pro Glu Asn Leu Phe Leu Lys
1265                1270                1275               1280 
Ser Asp Gly Arg Val Lys Tyr Thr Leu Asn Lys Asn Ser Leu Lys Ile
                1285                1290                1295    
Glu Ile Pro Leu Pro Phe Gly Gly Lys Ser Ser Arg Asp Leu Lys Met
            1300                1305                1310        
Leu Glu Thr Val Arg Thr Pro Ala Leu His Phe Lys Ser Val Gly Phe
        1315                1320                1325            
His Leu Pro Ser Arg Glu Phe Gln Val Pro Thr Phe Thr Ile Pro Lys
    1330                1335                1340                
Leu Tyr Gln Leu Gln Val Pro Leu Leu Gly Val Leu Asp Leu Ser Thr
1345                1350                1355               1360 
Asn Val Tyr Ser Asn Leu Tyr Asn Trp Ser Ala Ser Tyr Ser Gly Gly
                1365                1370                1375    
Asn Thr Ser Thr Asp His Phe Ser Leu Arg Ala Arg Tyr His Met Lys
            1380                1385                1390        
Ala Asp Ser Val Val Asp Leu Leu Ser Tyr Asn Val Gln Gly Ser Gly
        1395                1400                1405            
Glu Thr Thr Tyr Asp His Lys Asn Thr Phe Thr Leu Ser Cys Asp Gly
    1410                1415                1420                
Ser Leu Arg His Lys Phe Leu Asp Ser Asn Ile Lys Phe Ser His Val
1425                1430                1435               1440 
Glu Lys Leu Gly Asn Asn Pro Val Ser Lys Gly Leu Leu Ile Phe Asp
                1445                1450                1455    
Ala Ser Ser Ser Trp Gly Pro Gln Met Ser Ala Ser Val His Leu Asp
            1460                1465                1470        
Ser Lys Lys Lys Gln His Leu Phe Val Lys Glu Val Lys Ile Asp Gly
        1475                1480                1485            
Gln Phe Arg Val Ser Ser Phe Tyr Ala Lys Gly Thr Tyr Gly Leu Ser
    1490                1495                1500                
Cys Gln Arg Asp Pro Asn Thr Gly Arg Leu Asn Gly Glu Ser Asn Leu
1505                1510                1515               1520 
Arg Phe Asn Ser Ser Tyr Leu Gln Gly Thr Asn Gln Ile Thr Gly Arg
                1525                1530                1535    
Tyr Glu Asp Gly Thr Leu Ser Leu Thr Ser Thr Ser Asp Leu Gln Ser
            1540                1545                1550        
Gly Ile Ile Lys Asn Thr Ala Ser Leu Lys Tyr Glu Asn Tyr Glu Leu
        1555                1560                1565            
Thr Leu Lys Ser Asp Thr Asn Gly Lys Tyr Lys Asn Phe Ala Thr Ser
    1570                1575                1580                
Asn Lys Met Asp Met Thr Phe Ser Lys Gln Asn Ala Leu Leu Arg Ser
1585                1590                1595               1600 
Glu Tyr Gln Ala Asp Tyr Glu Ser Leu Arg Phe Phe Ser Leu Leu Ser
                1605                1610                1615    
Gly Ser Leu Asn Ser His Gly Leu Glu Leu Asn Ala Asp Ile Leu Gly
            1620                1625                1630        
Thr Asp Lys Ile Asn Ser Gly Ala His Lys Ala Thr Leu Arg Ile Gly
        1635                1640                1645            
Gln Asp Gly Ile Ser Thr Ser Ala Thr Thr Asn Leu Lys Cys Ser Leu
    1650                1655                1660                
Leu Val Leu Glu Asn Glu Leu Asn Ala Glu Leu Gly Leu Ser Gly Ala
1665                1670                1675               1680 
Ser Met Lys Leu Thr Thr Asn Gly Arg Phe Arg Glu His Asn Ala Lys
                1685                1690                1695    
Phe Ser Leu Asp Gly Lys Ala Ala Leu Thr Glu Leu Ser Leu Gly Ser
            1700                1705                1710        
Ala Tyr Gln Ala Met Ile Leu Gly Val Asp Ser Lys Asn Ile Phe Asn
        1715                1720                1725            
Phe Lys Val Ser Gln Glu Gly Leu Lys Leu Ser Asn Asp Met Met Gly
    1730                1735                1740                
Ser Tyr Ala Glu Met Lys Phe Asp His Thr Asn Ser Leu Asn Ile Ala
1745                1750                1755               1760 
Gly Leu Ser Leu Asp Phe Ser Ser Lys Leu Asp Asn Ile Tyr Ser Ser
                1765                1770                1775    
Asp Lys Phe Tyr Lys Gln Thr Val Asn Leu Gln Leu Gln Pro Tyr Ser
            1780                1785                1790        
Leu Val Thr Thr Leu Asn Ser Asp Leu Lys Tyr Asn Ala Leu Asp Leu
        1795                1800                1805            
Thr Asn Asn Gly Lys Leu Arg Leu Glu Pro Leu Lys Leu His Val Ala
    1810                1815                1820                
Gly Asn Leu Lys Gly Ala Tyr Gln Asn Asn Glu Ile Lys His Ile Tyr
1825                1830                1835               1840 
Ala Ile Ser Ser Ala Ala Leu Ser Ala Ser Tyr Lys Ala Asp Thr Val
                1845                1850                1855    
Ala Lys Val Gln Gly Val Glu Phe Ser His Arg Leu Asn Thr Asp Ile
            1860                1865                1870        
Ala Gly Leu Ala Ser Ala Ile Asp Met Ser Thr Asn Tyr Asn Ser Asp
        1875                1880                1885            
Ser Leu His Phe Ser Asn Val Phe Arg Ser Val Met Ala Pro Phe Thr
    1890                1895                1900                
Met Thr Ile Asp Ala His Thr Asn Gly Asn Gly Lys Leu Ala Leu Trp
1905                1910                1915               1920 
Gly Glu His Thr Gly Gln Leu Tyr Ser Lys Phe Leu Leu Lys Ala Glu
                1925                1930                1935    
Pro Leu Ala Phe Thr Phe Ser His Asp Tyr Lys Gly Ser Thr Ser His
            1940                1945                1950        
His Leu Val Ser Arg Lys Ser Ile Ser Ala Ala Leu Glu His Lys Val
        1955                1960                1965            
Ser Ala Leu Leu Thr Pro Ala Glu Gln Thr Gly Thr Trp Lys Leu Lys
    1970                1975                1980                
Thr Gln Phe Asn Asn Asn Glu Tyr Ser Gln Asp Leu Asp Ala Tyr Asn
1985                1990                1995               2000 
Thr Lys Asp Lys Ile Gly Val Glu Leu Thr Gly Arg Thr Leu Ala Asp
                2005                2010                2015    
Leu Thr Leu Leu Asp Ser Pro Ile Lys Val Pro Leu Leu Leu Ser Glu
            2020                2025                2030        
Pro Ile Asn Ile Ile Asp Ala Leu Glu Met Arg Asp Ala Val Glu Lys
        2035                2040                2045            
Pro Gln Glu Phe Thr Ile Val Ala Phe Val Lys Tyr Asp Lys Asn Gln
    2050                2055                2060                
Asp Val His Ser Ile Asn Leu Pro Phe Phe Glu Thr Leu Gln Glu Tyr
2065                2070                2075               2080 
Phe Glu Arg Asn Arg Gln Thr Ile Ile Val Val Leu Glu Asn Val Gln
                2085                2090                2095    
Arg Asn Leu Lys His Ile Asn Ile Asp Gln Phe Val Arg Lys Tyr Arg
            2100                2105                2110        
Ala Ala Leu Gly Lys Leu Pro Gln Gln Ala Asn Asp Tyr Leu Asn Ser
        2115                2120                2125            
Phe Asn Trp Glu Arg Gln Val Ser His Ala Lys Glu Lys Leu Thr Ala
    2130                2135                2140                
Leu Thr Lys Lys Tyr Arg Ile Thr Glu Asn Asp Ile Gln Ile Ala Leu
2145                2150                2155               2160 
Asp Asp Ala Lys Ile Asn Phe Asn Glu Lys Leu Ser Gln Leu Gln Thr
                2165                2170                2175    
Tyr Met Ile Gln Phe Asp Gln Tyr Ile Lys Asp Ser Tyr Asp Leu His
            2180                2185                2190        
Asp Leu Lys Ile Ala Ile Ala Asn Ile Ile Asp Glu Ile Ile Glu Lys
        2195                2200                2205            
Leu Lys Ser Leu Asp Glu His Tyr His Ile Arg Val Asn Leu Val Lys
    2210                2215                2220                
Thr Ile His Asp Leu His Leu Phe Ile Glu Asn Ile Asp Phe Asn Lys
2225                2230                2235               2240 
Ser Gly Ser Ser Thr Ala Ser Trp Ile Gln Asn Val Asp Thr Lys Tyr
                2245                2250                2255    
Gln Ile Arg Ile Gln Ile Gln Glu Lys Leu Gln Gln Leu Lys Arg His
            2260                2265                2270        
Ile Gln Asn Ile Asp Ile Gln His Leu Ala Gly Lys Leu Lys Gln His
        2275                2280                2285            
Ile Glu Ala Ile Asp Val Arg Val Leu Leu Asp Gln Leu Gly Thr Thr
    2290                2295                2300                
Ile Ser Phe Glu Arg Ile Asn Asp Val Leu Glu His Val Lys His Phe
2305                2310                2315               2320 
Val Ile Asn Leu Ile Gly Asp Phe Glu Val Ala Glu Lys Ile Asn Ala
                2325                2330                2335    
Phe Arg Ala Lys Val His Glu Leu Ile Glu Arg Tyr Glu Val Asp Gln
            2340                2345                2350        
Gln Ile Gln Val Leu Met Asp Lys Leu Val Glu Leu Ala His Gln Tyr
        2355                2360                2365            
Lys Leu Lys Glu Thr Ile Gln Lys Leu Ser Asn Val Leu Gln Gln Val
    2370                2375                2380                
Lys Ile Lys Asp Tyr Phe Glu Lys Leu Val Gly Phe Ile Asp Asp Ala
2385                2390                2395               2400 
Val Lys Lys Leu Asn Glu Leu Ser Phe Lys Thr Phe Ile Glu Asp Val
                2405                2410                2415    
Asn Lys Phe Leu Asp Met Leu Ile Lys Lys Leu Lys Ser Phe Asp Tyr
            2420                2425                2430        
His Gln Phe Val Asp Glu Thr Asn Asp Lys Ile Arg Glu Val Thr Gln
        2435                2440                2445            
Arg Leu Asn Gly Glu Ile Gln Ala Leu Glu Leu Pro Gln Lys Ala Glu
    2450                2455                2460                
Ala Leu Lys Leu Phe Leu Glu Glu Thr Lys Ala Thr Val Ala Val Tyr
2465                2470                2475               2480 
Leu Glu Ser Leu Gln Asp Thr Lys Ile Thr Leu Ile Ile Asn Trp Leu
                2485                2490                2495    
Gln Glu Ala Leu Ser Ser Ala Ser Leu Ala His Met Lys Ala Lys Phe
            2500                2505                2510        
Arg Glu Thr Leu Glu Asp Thr Arg Asp Arg Met Tyr Gln Met Asp Ile
        2515                2520                2525            
Gln Gln Glu Leu Gln Arg Tyr Leu Ser Leu Val Gly Gln Val Tyr Ser
    2530                2535                2540                
Thr Leu Val Thr Tyr Ile Ser Asp Trp Trp Thr Leu Ala Ala Lys Asn
2545                2550                2555               2560 
Leu Thr Asp Phe Ala Glu Gln Tyr Ser Ile Gln Asp Trp Ala Lys Arg
                2565                2570                2575    
Met Lys Ala Leu Val Glu Gln Gly Phe Thr Val Pro Glu Ile Lys Thr
            2580                2585                2590        
Ile Leu Gly Thr Met Pro Ala Phe Glu Val Ser Leu Gln Ala Leu Gln
        2595                2600                2605            
Lys Ala Thr Phe Gln Thr Pro Asp Phe Ile Val Pro Leu Thr Asp Leu
    2610                2615                2620                
Arg Ile Pro Ser Val Gln Ile Asn Phe Lys Asp Leu Lys Asn Ile Lys
2625                2630                2635               2640 
Ile Pro Ser Arg Phe Ser Thr Pro Glu Phe Thr Ile Leu Asn Thr Phe
                2645                2650                2655    
His Ile Pro Ser Phe Thr Ile Asp Phe Val Glu Met Lys Val Lys Ile
            2660                2665                2670        
Ile Arg Thr Ile Asp Gln Met Leu Asn Ser Glu Leu Gln Trp Pro Val
        2675                2680                2685            
Pro Asp Ile Tyr Leu Arg Asp Leu Lys Val Glu Asp Ile Pro Leu Ala
    2690                2695                2700                
Arg Ile Thr Leu Pro Asp Phe Arg Leu Pro Glu Ile Ala Ile Pro Glu
2705                2710                2715               2720 
Phe Ile Ile Pro Thr Leu Asn Leu Asn Asp Phe Gln Val Pro Asp Leu
                2725                2730                2735    
His Ile Pro Glu Phe Gln Leu Pro His Ile Ser His Thr Ile Glu Val
            2740                2745                2750        
Pro Thr Phe Gly Lys Leu Tyr Ser Ile Leu Lys Ile Gln Ser Pro Leu
        2755                2760                2765            
Phe Thr Leu Asp Ala Asn Ala Asp Ile Gly Asn Gly Thr Thr Ser Ala
    2770                2775                2780                
Asn Glu Ala Gly Ile Ala Ala Ser Ile Thr Ala Lys Gly Glu Ser Lys
2785                2790                2795               2800 
Leu Glu Val Leu Asn Phe Asp Phe Gln Ala Asn Ala Gln Leu Ser Asn
                2805                2810                2815    
Pro Lys Ile Asn Pro Leu Ala Leu Lys Glu Ser Val Lys Phe Ser Ser
            2820                2825                2830        
Lys Tyr Leu Arg Thr Glu His Gly Ser Glu Met Leu Phe Phe Gly Asn
        2835                2840                2845            
Ala Ile Glu Gly Lys Ser Asn Thr Val Ala Ser Leu His Thr Glu Lys
    2850                2855                2860                
Asn Thr Leu Glu Leu Ser Asn Gly Val Ile Val Lys Ile Asn Asn Gln
2865                2870                2875               2880 
Leu Thr Leu Asp Ser Asn Thr Lys Tyr Phe His Lys Leu Asn Ile Pro
                2885                2890                2895    
Lys Leu Asp Phe Ser Ser Gln Ala Asp Leu Arg Asn Glu Ile Lys Thr
            2900                2905                2910        
Leu Leu Lys Ala Gly His Ile Ala Trp Thr Ser Ser Gly Lys Gly Ser
        2915                2920                2925            
Trp Lys Trp Ala Cys Pro Arg Phe Ser Asp Glu Gly Thr His Glu Ser
    2930                2935                2940                
Gln Ile Ser Phe Thr Ile Glu Gly Pro Leu Thr Ser Phe Gly Leu Ser
2945                2950                2955               2960 
Asn Lys Ile Asn Ser Lys His Leu Arg Val Asn Gln Asn Leu Val Tyr
                2965                2970                2975    
Glu Ser Gly Ser Leu Asn Phe Ser Lys Leu Glu Ile Gln Ser Gln Val
            2980                2985                2990        
Asp Ser Gln His Val Gly His Ser Val Leu Thr Ala Lys Gly Met Ala
        2995                3000                3005            
Leu Phe Gly Glu Gly Lys Ala Glu Phe Thr Gly Arg His Asp Ala His
    3010                3015                3020                
Leu Asn Gly Lys Val Ile Gly Thr Leu Lys Asn Ser Leu Phe Phe Ser
3025                3030                3035               3040 
Ala Gln Pro Phe Glu Ile Thr Ala Ser Thr Asn Asn Glu Gly Asn Leu
                3045                3050                3055    
Lys Val Arg Phe Pro Leu Arg Leu Thr Gly Lys Ile Asp Phe Leu Asn
            3060                3065                3070        
Asn Tyr Ala Leu Phe Leu Ser Pro Ser Ala Gln Gln Ala Ser Trp Gln
        3075                3080                3085            
Val Ser Ala Arg Phe Asn Gln Tyr Lys Tyr Asn Gln Asn Phe Ser Ala
    3090                3095                3100                
Gly Asn Asn Glu Asn Ile Met Glu Ala His Val Gly Ile Asn Gly Glu
3105                3110                3115               3120 
Ala Asn Leu Asp Phe Leu Asn Ile Pro Leu Thr Ile Pro Glu Met Arg
                3125                3130                3135    
Leu Pro Tyr Thr Ile Ile Thr Thr Pro Pro Leu Lys Asp Phe Ser Leu
            3140                3145                3150        
Trp Glu Lys Thr Gly Leu Lys Glu Phe Leu Lys Thr Thr Lys Gln Ser
        3155                3160                3165            
Phe Asp Leu Ser Val Lys Ala Gln Tyr Lys Lys Asn Lys His Arg His
    3170                3175                3180                
Ser Ile Thr Asn Pro Leu Ala Val Leu Cys Glu Phe Ile Ser Gln Ser
3185                3190                3195               3200 
Ile Lys Ser Phe Asp Arg His Phe Glu Lys Asn Arg Asn Asn Ala Leu
                3205                3210                3215    
Asp Phe Val Thr Lys Ser Tyr Asn Glu Thr Lys Ile Lys Phe Asp Lys
            3220                3225                3230        
Tyr Lys Ala Glu Lys Ser His Asp Glu Leu Pro Arg Thr Phe Gln Ile
        3235                3240                3245            
Pro Gly Tyr Thr Val Pro Val Val Asn Val Glu Val Ser Pro Phe Thr
    3250                3255                3260                
Ile Glu Met Ser Ala Phe Gly Tyr Val Phe Pro Lys Ala Val Ser Met
3265                3270                3275               3280 
Pro Ser Phe Ser Ile Leu Gly Ser Asp Val Arg Val Pro Ser Tyr Thr
                3285                3290                3295    
Leu Ile Leu Pro Ser Leu Glu Leu Pro Val Leu His Val Pro Arg Asn
            3300                3305                3310        
Leu Lys Leu Ser Leu Pro Asp Phe Lys Glu Leu Cys Thr Ile Ser His
        3315                3320                3325            
Ile Phe Ile Pro Ala Met Gly Asn Ile Thr Tyr Asp Phe Ser Phe Lys
    3330                3335                3340                
Ser Ser Val Ile Thr Leu Asn Thr Asn Ala Glu Leu Phe Asn Gln Ser
3345                3350                3355               3360 
Asp Ile Val Ala His Leu Leu Ser Ser Ser Ser Ser Val Ile Asp Ala
                3365                3370                3375    
Leu Gln Tyr Lys Leu Glu Gly Thr Thr Arg Leu Thr Arg Lys Arg Gly
            3380                3385                3390        
Leu Lys Leu Ala Thr Ala Leu Ser Leu Ser Asn Lys Phe Val Glu Gly
        3395                3400                3405            
Ser His Asn Ser Thr Val Ser Leu Thr Thr Lys Asn Met Glu Val Ser
    3410                3415                3420                
Val Ala Thr Thr Thr Lys Ala Gln Ile Pro Ile Leu Arg Met Asn Phe
3425                3430                3435               3440 
Lys Gln Glu Leu Asn Gly Asn Thr Lys Ser Lys Pro Thr Val Ser Ser
                3445                3450                3455    
Ser Met Glu Phe Lys Tyr Asp Phe Asn Ser Ser Met Leu Tyr Ser Thr
            3460                3465                3470        
Ala Lys Gly Ala Val Asp His Lys Leu Ser Leu Glu Ser Leu Thr Ser
        3475                3480                3485            
Tyr Phe Ser Ile Glu Ser Ser Thr Lys Gly Asp Val Lys Gly Ser Val
    3490                3495                3500                
Leu Ser Arg Glu Tyr Ser Gly Thr Ile Ala Ser Glu Ala Asn Thr Tyr
3505                3510                3515               3520 
Leu Asn Ser Lys Ser Thr Arg Ser Ser Val Lys Leu Gln Gly Thr Ser
                3525                3530                3535    
Lys Ile Asp Asp Ile Trp Asn Leu Glu Val Lys Glu Asn Phe Ala Gly
            3540                3545                3550        
Glu Ala Thr Leu Gln Arg Ile Tyr Ser Leu Trp Glu His Ser Thr Lys
        3555                3560                3565            
Asn His Leu Gln Leu Glu Gly Leu Phe Phe Thr Asn Gly Glu His Thr
    3570                3575                3580                
Ser Lys Ala Thr Leu Glu Leu Ser Pro Trp Gln Met Ser Ala Leu Val
3585                3590                3595               3600 
Gln Val His Ala Ser Gln Pro Ser Ser Phe His Asp Phe Pro Asp Leu
                3605                3610                3615    
Gly Gln Glu Val Ala Leu Asn Ala Asn Thr Lys Asn Gln Lys Ile Arg
            3620                3625                3630        
Trp Lys Asn Glu Val Arg Ile His Ser Gly Ser Phe Gln Ser Gln Val
        3635                3640                3645            
Glu Leu Ser Asn Asp Gln Glu Lys Ala His Leu Asp Ile Ala Gly Ser
    3650                3655                3660                
Leu Glu Gly His Leu Arg Phe Leu Lys Asn Ile Ile Leu Pro Val Tyr
3665                3670                3675               3680 
Asp Lys Ser Leu Trp Asp Phe Leu Lys Leu Asp Val Thr Thr Ser Ile
                3685                3690                3695    
Gly Arg Arg Gln His Leu Arg Val Ser Thr Ala Phe Val Tyr Thr Lys
            3700                3705                3710        
Asn Pro Asn Gly Tyr Ser Phe Ser Ile Pro Val Lys Val Leu Ala Asp
        3715                3720                3725            
Lys Phe Ile Ile Pro Gly Leu Lys Leu Asn Asp Leu Asn Ser Val Leu
    3730                3735                3740                
Val Met Pro Thr Phe His Val Pro Phe Thr Asp Leu Gln Val Pro Ser
3745                3750                3755               3760 
Cys Lys Leu Asp Phe Arg Glu Ile Gln Ile Tyr Lys Lys Leu Arg Thr
                3765                3770                3775    
Ser Ser Phe Ala Leu Asn Leu Pro Thr Leu Pro Glu Val Lys Phe Pro
            3780                3785                3790        
Glu Val Asp Val Leu Thr Lys Tyr Ser Gln Pro Glu Asp Ser Leu Ile
        3795                3800                3805            
Pro Phe Phe Glu Ile Thr Val Pro Glu Ser Gln Leu Thr Val Ser Gln
    3810                3815                3820                
Phe Thr Leu Pro Lys Ser Val Ser Asp Gly Ile Ala Ala Leu Asp Leu
3825                3830                3835               3840 
Asn Ala Val Ala Asn Lys Ile Ala Asp Phe Glu Leu Pro Thr Ile Ile
                3845                3850                3855    
Val Pro Glu Gln Thr Ile Glu Ile Pro Ser Ile Lys Phe Ser Val Pro
            3860                3865                3870        
Ala Gly Ile Val Ile Pro Ser Phe Gln Ala Leu Thr Ala Arg Phe Glu
        3875                3880                3885            
Val Asp Ser Pro Val Tyr Asn Ala Thr Trp Ser Ala Ser Leu Lys Asn
    3890                3895                3900                
Lys Ala Asp Tyr Val Glu Thr Val Leu Asp Ser Thr Cys Ser Ser Thr
3905                3910                3915               3920 
Val Gln Phe Leu Glu Tyr Glu Leu Asn Val Leu Gly Thr His Lys Ile
                3925                3930                3935    
Glu Asp Gly Thr Leu Ala Ser Lys Thr Lys Gly Thr Phe Ala His Arg
            3940                3945                3950        
Asp Phe Ser Ala Glu Tyr Glu Glu Asp Gly Lys Tyr Glu Gly Leu Gln
        3955                3960                3965            
Glu Trp Glu Gly Lys Ala His Leu Asn Ile Lys Ser Pro Ala Phe Thr
    3970                3975                3980                
Asp Leu His Leu Arg Tyr Gln Lys Asp Lys Lys Gly Ile Ser Thr Ser
3985                3990                3995               4000 
Ala Ala Ser Pro Ala Val Gly Thr Val Gly Met Asp Met Asp Glu Asp
                4005                4010                4015    
Asp Asp Phe Ser Lys Trp Asn Phe Tyr Tyr Ser Pro Gln Ser Ser Pro
            4020                4025                4030        
Asp Lys Lys Leu Thr Ile Phe Lys Thr Glu Leu Arg Val Arg Glu Ser
        4035                4040                4045            
Asp Glu Glu Thr Gln Ile Lys Val Asn Trp Glu Glu Glu Ala Ala Ser
    4050                4055                4060                
Gly Leu Leu Thr Ser Leu Lys Asp Asn Val Pro Lys Ala Thr Gly Val
4065                4070                4075               4080 
Leu Tyr Asp Tyr Val Asn Lys Tyr His Trp Glu His Thr Gly Leu Thr
                4085                4090                4095    
Leu Arg Glu Val Ser Ser Lys Leu Arg Arg Asn Leu Gln Asn Asn Ala
            4100                4105                4110        
Glu Trp Val Tyr Gln Gly Ala Ile Arg Gln Ile Asp Asp Ile Asp Val
        4115                4120                4125            
Arg Phe Gln Lys Ala Ala Ser Gly Thr Thr Gly Thr Tyr Gln Glu Trp
    4130                4135                4140                
Lys Asp Lys Ala Gln Asn Leu Tyr Gln Glu Leu Leu Thr Gln Glu Gly
4145                4150                4155               4160 
Gln Ala Ser Phe Gln Gly Leu Lys Asp Asn Val Phe Asp Gly Leu Val
                4165                4170                4175    
Arg Val Thr Gln Glu Phe His Met Lys Val Lys His Leu Ile Asp Ser
            4180                4185                4190        
Leu Ile Asp Phe Leu Asn Phe Pro Arg Phe Gln Phe Pro Gly Lys Pro
        4195                4200                4205            
Gly Ile Tyr Thr Arg Glu Glu Leu Cys Thr Met Phe Ile Arg Glu Val
    4210                4215                4220                
Gly Thr Val Leu Ser Gln Val Tyr Ser Lys Val His Asn Gly Ser Glu
4225                4230                4235               4240 
Ile Leu Phe Ser Tyr Phe Gln Asp Leu Val Ile Thr Leu Pro Phe Glu
                4245                4250                4255    
Leu Arg Lys His Lys Leu Ile Asp Val Ile Ser Met Tyr Arg Glu Leu
            4260                4265                4270        
Leu Lys Asp Leu Ser Lys Glu Ala Gln Glu Val Phe Lys Ala Ile Gln
        4275                4280                4285            
Ser Leu Lys Thr Thr Glu Val Leu Arg Asn Leu Gln Asp Leu Leu Gln
    4290                4295                4300                
Phe Ile Phe Gln Leu Ile Glu Asp Asn Ile Lys Gln Leu Lys Glu Met
4305                4310                4315               4320 
Lys Phe Thr Tyr Leu Ile Asn Tyr Ile Gln Asp Glu Ile Asn Thr Ile
                4325                4330                4335    
Phe Ser Asp Tyr Ile Pro Tyr Val Phe Lys Leu Leu Lys Glu Asn Leu
            4340                4345                4350        
Cys Leu Asn Leu His Lys Phe Asn Glu Phe Ile Gln Asn Glu Leu Gln
        4355                4360                4365            
Glu Ala Ser Gln Glu Leu Gln Gln Ile His Gln Tyr Ile Met Ala Leu
    4370                4375                4380                
Arg Glu Glu Tyr Phe Asp Pro Ser Ile Val Gly Trp Thr Val Lys Tyr
4385                4390                4395               4400 
Tyr Glu Leu Glu Glu Lys Ile Val Ser Leu Ile Lys Asn Leu Leu Val
                4405                4410                4415    
Ala Leu Lys Asp Phe His Ser Glu Tyr Ile Val Ser Ala Ser Asn Phe
            4420                4425                4430        
Thr Ser Gln Leu Ser Ser Gln Val Glu Gln Phe Leu His Arg Asn Ile
        4435                4440                4445            
Gln Glu Tyr Leu Ser Ile Leu Thr Asp Pro Asp Gly Lys Gly Lys Glu
    4450                4455                4460                
Lys Ile Ala Glu Leu Ser Ala Thr Ala Gln Glu Ile Ile Lys Ser Gln
4465                4470                4475               4480 
Ala Ile Ala Thr Lys Lys Ile Ile Ser Asp Tyr His Gln Gln Phe Arg
                4485                4490                4495    
Tyr Lys Leu Gln Asp Phe Ser Asp Gln Leu Ser Asp Tyr Tyr Glu Lys
            4500                4505                4510        
Phe Ile Ala Glu Ser Lys Arg Leu Ile Asp Leu Ser Ile Gln Asn Tyr
        4515                4520                4525            
His Thr Phe Leu Ile Tyr Ile Thr Glu Leu Leu Lys Lys Leu Gln Ser
    4530                4535                4540                
Thr Thr Val Met Asn Pro Tyr Met Lys Leu Ala Pro Gly Glu Leu Thr
4545                4550                4555               4560 
Ile Ile Leu

