
                                SEQUENCE LISTING

<110> Merck & Co., Inc.

<120> PD-1 Binding Proteins
  

<130> MRL-IFD-22463

<150> 61/069,060          
<151> 2008-03-12  

<160> 77

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 288
<212> PRT
<213> Homo sapien

<400> 1
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln
 1               5                  10                  15      
Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp
            20                  25                  30          
Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp
        35                  40                  45              
Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val
    50                  55                  60                  
Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala
65                  70                  75                  80  
Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg
                85                  90                  95      
Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg
            100                 105                 110         
Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu
        115                 120                 125             
Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val
    130                 135                 140                 
Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro
145                 150                 155                 160 
Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly
                165                 170                 175     
Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys
            180                 185                 190         
Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro
        195                 200                 205             
Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly
    210                 215                 220                 
Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro
225                 230                 235                 240 
Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly
                245                 250                 255     
Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg
            260                 265                 270         
Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu
        275                 280                 285             


<210> 2
<211> 290
<212> PRT
<213> Homo sapien

<400> 2
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu
 1               5                  10                  15      
Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr
            20                  25                  30          
Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu
        35                  40                  45              
Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile
    50                  55                  60                  
Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser
65                  70                  75                  80  
Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn
                85                  90                  95      
Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr
            100                 105                 110         
Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val
        115                 120                 125             
Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val
    130                 135                 140                 
Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr
145                 150                 155                 160 
Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser
                165                 170                 175     
Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn
            180                 185                 190         
Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr
        195                 200                 205             
Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu
    210                 215                 220                 
Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His
225                 230                 235                 240 
Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr
                245                 250                 255     
Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys
            260                 265                 270         
Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu
        275                 280                 285             
Glu Thr
    290 


<210> 3
<211> 4867
<212> DNA
<213> Artificial Sequence

<220> 
<223> V1Jns

<400> 3
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca 60
cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg 120
ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc 180
accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg 240
ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg 300
tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac 360
ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg 420
cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc 480
catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac 540
tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa 600
tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac 660
ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta 720
catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga 780
cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa 840
ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag 900
agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca 960
tagaagacac cgggaccgat ccagcctccg cggccgggaa cggtgcattg gaacgcggat 1020
tccccgtgcc aagagtgacg taagtaccgc ctatagactc tataggcaca cccctttggc 1080
tcttatgcat gctatactgt ttttggcttg gggcctatac acccccgctt ccttatgcta 1140
taggtgatgg tatagcttag cctataggtg tgggttattg accattattg accactcccc 1200
tattggtgac gatactttcc attactaatc cataacatgg ctctttgcca caactatctc 1260
tattggctat atgccaatac tctgtccttc agagactgac acggactctg tatttttaca 1320
ggatggggtc ccatttatta tttacaaatt cacatataca acaacgccgt cccccgtgcc 1380
cgcagttttt attaaacata gcgtgggatc tccacgcgaa tctcgggtac gtgttccgga 1440
catgggctct tctccggtag cggcggagct tccacatccg agccctggtc ccatgcctcc 1500
agcggctcat ggtcgctcgg cagctccttg ctcctaacag tggaggccag acttaggcac 1560
agcacaatgc ccaccaccac cagtgtgccg cacaaggccg tggcggtagg gtatgtgtct 1620
gaaaatgagc gtggagattg ggctcgcacg gctgacgcag atggaagact taaggcagcg 1680
gcagaagaag atgcaggcag ctgagttgtt gtattctgat aagagtcaga ggtaactccc 1740
gttgcggtgc tgttaacggt ggagggcagt gtagtctgag cagtactcgt tgctgccgcg 1800
cgcgccacca gacataatag ctgacagact aacagactgt tcctttccat gggtcttttc 1860
tgcagtcacc gtccttagat ctgctgtgcc ttctagttgc cagccatctg ttgtttgccc 1920
ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa 1980
tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg 2040
gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg 2100
ctctatggcc gctgcggcca ggtgctgaag aattgacccg gttcctcctg ggccagaaag 2160
aagcaggcac atccccttct ctgtgacaca ccctgtccac gcccctggtt cttagttcca 2220
gccccactca taggacactc atagctcagg agggctccgc cttcaatccc acccgctaaa 2280
gtacttggag cggtctctcc ctccctcatc agcccaccaa accaaaccta gcctccaaga 2340
gtgggaagaa attaaagcaa gataggctat taagtgcaga gggagagaaa atgcctccaa 2400
catgtgagga agtaatgaga gaaatcatag aatttcttcc gcttcctcgc tcactgactc 2460
gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg 2520
gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa 2580
ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga 2640
cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag 2700
ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct 2760
taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg 2820
ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc 2880
ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt 2940
aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta 3000
tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac 3060
agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc 3120
ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat 3180
tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc 3240
tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt 3300
cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta 3360
aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct 3420
atttcgttca tccatagttg cctgactcgg gggggggggg cgctgaggtc tgcctcgtga 3480
agaaggtgtt gctgactcat accaggcctg aatcgcccca tcatccagcc agaaagtgag 3540
ggagccacgg ttgatgagag ctttgttgta ggtggaccag ttggtgattt tgaacttttg 3600
ctttgccacg gaacggtctg cgttgtcggg aagatgcgtg atctgatcct tcaactcagc 3660
aaaagttcga tttattcaac aaagccgccg tcccgtcaag tcagcgtaat gctctgccag 3720
tgttacaacc aattaaccaa ttctgattag aaaaactcat cgagcatcaa atgaaactgc 3780
aatttattca tatcaggatt atcaatacca tatttttgaa aaagccgttt ctgtaatgaa 3840
ggagaaaact caccgaggca gttccatagg atggcaagat cctggtatcg gtctgcgatt 3900
ccgactcgtc caacatcaat acaacctatt aatttcccct cgtcaaaaat aaggttatca 3960
agtgagaaat caccatgagt gacgactgaa tccggtgaga atggcaaaag cttatgcatt 4020
tctttccaga cttgttcaac aggccagcca ttacgctcgt catcaaaatc actcgcatca 4080
accaaaccgt tattcattcg tgattgcgcc tgagcgagac gaaatacgcg atcgctgtta 4140
aaaggacaat tacaaacagg aatcgaatgc aaccggcgca ggaacactgc cagcgcatca 4200
acaatatttt cacctgaatc aggatattct tctaatacct ggaatgctgt tttcccgggg 4260
atcgcagtgg tgagtaacca tgcatcatca ggagtacgga taaaatgctt gatggtcgga 4320
agaggcataa attccgtcag ccagtttagt ctgaccatct catctgtaac atcattggca 4380
acgctacctt tgccatgttt cagaaacaac tctggcgcat cgggcttccc atacaatcga 4440
tagattgtcg cacctgattg cccgacatta tcgcgagccc atttataccc atataaatca 4500
gcatccatgt tggaatttaa tcgcggcctc gagcaagacg tttcccgttg aatatggctc 4560
ataacacccc ttgtattact gtttatgtaa gcagacagtt ttattgttca tgatgatata 4620
tttttatctt gtgcaatgta acatcagaga ttttgagaca caacgtggct ttcccccccc 4680
ccccattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt 4740
atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac 4800
gtctaagaaa ccattattat catgacatta acctataaaa ataggcgtat cacgaggccc 4860
tttcgtc                                                           4867

<210> 4
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1B8 Vh

<400> 4
Glu Val Gln Leu Val Leu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Asn Pro Glu Arg Arg Leu Val Trp Val
        35                  40                  45              
Ala Thr Ile Thr Gly Gly Gly Arg Asn Thr Tyr Tyr Pro Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Thr Arg Gln Gly Tyr Asp Gly Tyr Thr Trp Phe Ala Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser
        115                 


<210> 5
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1B8 V1

<400> 5
Asp Ile Val Leu Thr Gln Ser Pro Thr Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Ser
            20                  25                  30          
Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Pro Gly Ser Gly Val Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65                  70                  75                  80  
Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Arg
            100                 105                 110         


<210> 6
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1B8 Vh CDR1

<400> 6
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser
 1               5                  10              


<210> 7
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1B8 Vh CDR2

<400> 7
Thr Ile Thr Gly Gly Gly Arg Asn Thr Tyr Tyr Pro Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 8
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1B8 Vh CDR3

<400> 8
Gln Gly Tyr Asp Gly Tyr Thr Trp Phe Ala Tyr
 1               5                  10      


<210> 9
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1B8 and 20B3.1 V1 CDR1

<400> 9
Arg Ala Ser Glu Ser Val Asp Asn Ser Gly Ile Ser Phe Met Asn
 1               5                  10                  15  


<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1B8 V1 CDR2

<400> 10
Ala Ala Ser Asn Pro Gly Ser
 1               5          


<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1B8 and 20B3.1 V1 CDR3

<400> 11
Gln Gln Ser Lys Glu Val Pro Trp Thr
 1               5                  


<210> 12
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 20B3.1 Vh

<400> 12
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
        35                  40                  45              
Ala Thr Ile Ser Gly Gly Gly Ser Asn Thr Tyr Tyr Pro Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr
65                  70                  75                  80  
Leu Gln Met Thr Ser Leu Thr Ser Glu Asp Thr Ala Leu Tyr Tyr Cys
                85                  90                  95      
Thr Arg Ile Tyr Asp Val Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser
        115         


<210> 13
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 20B3.1 V1

<400> 13
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Ser
            20                  25                  30          
Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65                  70                  75                  80  
Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105                 110         


<210> 14
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 20B3.1 Vh CDR1

<400> 14
Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser
 1               5                  10              


<210> 15
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 20B3.1 Vh CDR2

<400> 15
Thr Ile Ser Gly Gly Gly Ser Asn Thr Tyr Tyr Pro Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 20B3.1 Vh CDR3

<400> 16
Ile Tyr Asp Val Ala Trp Phe Ala Tyr
 1               5                  


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 20B3.1 V1 CDR2

<400> 17
Ala Ala Ser Asn Gln Gly Ser
 1               5          


<210> 18
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7G3 Vh

<400> 18
Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Arg Pro Gly Val
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Ala Leu His Trp Met Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Ser Thr His Tyr Gly Asp Thr Val Tyr Asn Gln Arg Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Tyr Gly Ser Leu Phe Tyr Phe Asp Gln Trp Gly Gln
            100                 105                 110         
Gly Thr Pro Leu Thr Val Ser
        115                 


<210> 19
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7G3 V1

<400> 19
Cys Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp
 1               5                  10                  15      
Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser Asp
            20                  25                  30          
Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Ser Gly Gln Ser Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser
65                  70                  75                  80  
Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser
                85                  90                  95      
His Val Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Arg Arg
            100                 105                 110         


<210> 20
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7G3 Vh CDR1

<400> 20
Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr Ala Leu His
 1               5                  10              


<210> 21
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7G3 Vh CDR2

<400> 21
Val Ile Ser Thr His Tyr Gly Asp Thr Val Tyr Asn Gln Arg Phe Lys
 1               5                  10                  15      
Gly
    


<210> 22
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7G3 Vh CDR3

<400> 22
Glu Gly Tyr Gly Ser Leu Phe Tyr Phe Asp Gln
 1               5                  10      


<210> 23
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7G3 V1 CDR1

<400> 23
Arg Ser Ser Gln Thr Ile Val His Ser Asp Gly Asn Thr Tyr Leu Glu
 1               5                  10                  15      


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7G3, 1.8A10 and  28.11.1 V1 CDR2

<400> 24
Lys Val Ser Asn Arg Phe Ser
 1               5          


<210> 25
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7G3, and 1.8A10 V1 CDR3

<400> 25
Phe Gln Gly Ser His Val Pro Tyr Thr
 1               5                  


<210> 26
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1G7 Vh

<400> 26
Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr
            20                  25                  30          
Asn Ile Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asp Leu Tyr Asn Gly Asp Thr Ser Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Arg Glu Gly Arg Leu Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110         
Val Thr Val Ser Ala Ala
        115             


<210> 27
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1G7 V1

<400> 27
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr
            20                  25                  30          
Gly Asn Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Leu
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Asp Ser Gly Val Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Asp
65                  70                  75                  80  
Pro Val Glu Ala Asp Asp Pro Ala Thr Tyr Tyr Cys Gln Gln Asn Asn
                85                  90                  95      
Glu Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg
            100                 105                 110         


<210> 28
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1G7 Vh CDR1

<400> 28
Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr Asn Ile Tyr
 1               5                  10              


<210> 29
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1G7 Vh CDR2

<400> 29
Tyr Ile Asp Leu Tyr Asn Gly Asp Thr Ser Tyr Asn Glu Lys Phe
 1               5                  10                  15  


<210> 30
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1G7 Vh CDR3

<400> 30
Glu Gly Arg Leu Ser Phe Asp Tyr
 1               5              


<210> 31
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1G7 V1 CDR1

<400> 31
Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met Asn
 1               5                  10                  15  


<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1G7 V1 CDR2

<400> 32
Leu Ala Ser Asn Leu Asp Ser
 1               5          


<210> 33
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1G7 V1 CDR3

<400> 33
Gln Gln Asn Asn Glu Val Pro Leu Thr
 1               5                  


<210> 34
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1.8A10 Vh

<400> 34
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
            20                  25                  30          
Asp Met Ser Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
        35                  40                  45              
Ala Tyr Ile Ser Gly Gly Gly Gly Asn Thr Tyr Tyr Pro Asp Thr Leu
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Phe Tyr Cys
                85                  90                  95      
Val Arg Ile Ser Leu Thr Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Leu Thr Val Ser Ser Ala
        115                 


<210> 35
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1.8A10 V1

<400> 35
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Gln Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 36
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1.8A10 Vh CDR1

<400> 36
Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Asp Met Ser
 1               5                  10              


<210> 37
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1.8A10 Vh CDR2

<400> 37
Tyr Ile Ser Gly Gly Gly Gly Asn Thr Tyr Tyr Pro Asp Thr Leu
 1               5                  10                  15  


<210> 38
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1.8A10 Vh CDR3

<400> 38
Ile Ser Leu Thr Gly Ile Phe Asp Tyr
 1               5                  


<210> 39
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1.8A10 V1 CDR1

<400> 39
Arg Ser Ser Gln Ser Ile Val Gln Ser Asn Gly Asn Thr Tyr Leu Glu
 1               5                  10                  15      


<210> 40
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.1 Vh

<400> 40
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val
        35                  40                  45              
Ala Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys
                85                  90                  95      
Ala Ser Gly Asn Tyr Val Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Ser Val Thr Val Ser Ser Ala
        115                 


<210> 41
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.1 V1

<400> 41
Asp Val Met Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Gly
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 42
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.1 Vh CDR1

<400> 42
Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr Gly Met Ser
 1               5                  10              


<210> 43
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.1 Vh CDR2

<400> 43
Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Gln
 1               5                  10                  15      
Gly
    


<210> 44
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.1 Vh CDR3

<400> 44
Gly Asn Tyr Val Tyr Val Met Asp Tyr
 1               5                  


<210> 45
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.1 V1 CDR1

<400> 45
Arg Ser Ser Gln Thr Ile Val His Gly Asn Gly Asn Thr Tyr Leu Glu
 1               5                  10                  15      


<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.1 V1 CDR3

<400> 46
Phe Gln Gly Ser His Val Pro Tyr Thr
 1               5                  


<210> 47
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.2 Vh

<400> 47
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Val
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ile Phe Thr Asp Tyr
            20                  25                  30          
Val Met His Trp Val Lys Gln Ser Pro Ala Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Ser Thr Tyr Tyr Ser Asn Ile Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys
                85                  90                  95      
Ala Arg Glu Gly Phe Gly Arg Pro Tyr Trp Tyr Phe Asp Val Trp Gly
            100                 105                 110         
Ala Gly Thr Thr Val Thr Val Ser Ser Ala
        115                 120         


<210> 48
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.2 V1

<400> 48
Ala Tyr Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Glu Asn Ile Tyr Ser Ser
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Gly Thr Ser Asn
                85                  90                  95      
Val Glu Asn Pro Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105                 110     


<210> 49
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.2 Vh CDR1

<400> 49
Lys Gly Ser Gly Tyr Ile Phe Thr Asp Tyr Val Met His
 1               5                  10              


<210> 50
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.2 Vh CDR2

<400> 50
Val Ile Ser Thr Tyr Tyr Ser Asn Ile Asn Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 51
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.2 Vh CDR3

<400> 51
Glu Gly Phe Gly Arg Pro Tyr Trp Tyr Phe Asp Val
 1               5                  10          


<210> 52
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.2 V1 CDR1

<400> 52
Gln Ala Ser Glu Asn Ile Tyr Ser Ser Leu Ala
 1               5                  10      


<210> 53
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.2 V1 CDR2

<400> 53
Ser Ala Ser Thr Leu Ala Ser
 1               5          


<210> 54
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 28.11.2 V1 CDR3

<400> 54
Gln Gln Gly Phe Gly Thr Ser Asn Val Glu Asn Pro
 1               5                  10          


<210> 55
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 3H4 Vh

<400> 55
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Asn Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Ser Val Asn Thr Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Arg Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Ile Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Tyr Ser Asn Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Ala
            100                 105                 110         
Val Thr Val Ser
        115     


<210> 56
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 3H4 V1

<400> 56
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr
            20                  25                  30          
Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly
    50                  55                  60                  
Ser Arg Ser Gly Ser Asp Tyr Ser Leu Ser Ile Ser Ser Leu Glu Ser
65                  70                  75                  80  
Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105             


<210> 57
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 3H4 Vh CDR1

<400> 57
Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile Asn
 1               5                  10              


<210> 58
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 3H4 Vh CDR2

<400> 58
Trp Ile Tyr Pro Gly Ser Val Asn Thr Lys Tyr Asn Glu Lys Phe Arg
 1               5                  10                  15      
Gly
    


<210> 59
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 3H4 Vh CDR3

<400> 59
Tyr Ser Asn Trp Phe Phe Asp Val
 1               5              


<210> 60
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 3H4 V1 CDR1

<400> 60
Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Ser
 1               5                  10      


<210> 61
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 3H4 V1 CDR2

<400> 61
Ala Ala Ser Thr Leu Asp Ser
 1               5          


<210> 62
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 3H4 V1 CDR3

<400> 62
Leu Gln Tyr Ala Ser Tyr Pro Tyr Thr
 1               5                  


<210> 63
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 6D10 Vh

<400> 63
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Tyr Val Ser Ser Ala Ser Ser Val Ile His Tyr Ala Asp Thr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Gly Tyr Tyr Gly Thr Trp Phe Pro Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser
        115             


<210> 64
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 6D10 Vh CDR1

<400> 64
Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met His
 1               5                  10              


<210> 65
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 6D10 Vh CDR2

<400> 65
Tyr Val Ser Ser Ala Ser Ser Val Ile His Tyr Ala Asp Thr Val Lys
 1               5                  10                  15      
Gly
    


<210> 66
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 6D10 Vh CDR3

<400> 66
Ser Gly Tyr Tyr Gly Thr Trp Phe Pro Tyr
 1               5                  10  


<210> 67
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 2.3A9 Vh

<400> 67
Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Thr
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His
            20                  25                  30          
Ala Ile His Trp Leu Lys Gln Glu Pro Asp Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Ser Pro Gly Tyr Gly Asp Ile Glu Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Lys Val Thr Thr Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser
            100                 105                 110         


<210> 68
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 2.3A9 V1

<400> 68
Asp Val Leu Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly
                85                  90                  95      
Thr His Phe Pro His Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         
Arg
    


<210> 69
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 2.3A9 Vh CDR1

<400> 69
Lys Ala Ser Gly Tyr Thr Phe Thr Asp His Ala Ile His
 1               5                  10              


<210> 70
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 2.3A9 Vh CDR2

<400> 70
Tyr Ile Ser Pro Gly Tyr Gly Asp Ile Glu Tyr Asn Glu Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 71
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 2.3A9 Vh CDR3

<400> 71
Thr Thr Gly Tyr
 1              


<210> 72
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 2.3A9 V1 CDR1

<400> 72
Lys Ser Ser Gln Ser Leu Leu Asn Ser Asp Gly Lys Thr Tyr Leu Asn
 1               5                  10                  15      


<210> 73
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 2.3A9 V1 CDR2

<400> 73
Leu Val Ser Glu Leu Asp Ser
 1               5          


<210> 74
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 2.3A9 V1 CDR3

<400> 74
Trp Gln Gly Thr His Phe Pro His Thr
 1               5                  


<210> 75
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1B8 V1 and human kappa constant

<400> 75
Asp Ile Val Leu Thr Gln Ser Pro Thr Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Ser
            20                  25                  30          
Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Pro Gly Ser Gly Val Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
65                  70                  75                  80  
Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Arg
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215             


<210> 76
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1B8 Vh and human IgG constant

<400> 76
Glu Val Gln Leu Val Leu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Asn Pro Glu Arg Arg Leu Val Trp Val
        35                  40                  45              
Ala Thr Ile Thr Gly Gly Gly Arg Asn Thr Tyr Tyr Pro Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Thr Arg Gln Gly Tyr Asp Gly Tyr Thr Trp Phe Ala Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
        435                 440                 445             
Gly Lys
    450 


<210> 77
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 1B8 Vh and human IgG2m4 constant

<400> 77
Glu Val Gln Leu Val Leu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Asn Pro Glu Arg Arg Leu Val Trp Val
        35                  40                  45              
Ala Thr Ile Thr Gly Gly Gly Arg Asn Thr Tyr Tyr Pro Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Thr Arg Gln Gly Tyr Asp Gly Tyr Thr Trp Phe Ala Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Thr
            180                 185                 190         
Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val
    210                 215                 220                 
Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val
            260                 265                 270         
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
305                 310                 315                 320 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser
                325                 330                 335     
Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
            340                 345                 350         
Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
                405                 410                 415     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445     

