
                                SEQUENCE LISTING

<110> Conklin, Bruce R.
      Aalto-Setala, Katrina

<120> Cells and assays for use in detecting
  long QT syndrome

<130> GLAD-364WO

<150> 61/068,937          
<151> 2008-03-10  

<160> 9

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 676
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Ala Ala Ser Ser Pro Pro Arg Ala Glu Arg Lys Arg Trp Gly
 1               5                  10                  15      
Trp Gly Arg Leu Pro Gly Ala Arg Arg Gly Ser Ala Gly Leu Ala Lys
            20                  25                  30          
Lys Cys Pro Phe Ser Leu Glu Leu Ala Glu Gly Gly Pro Ala Gly Gly
        35                  40                  45              
Ala Leu Tyr Ala Pro Ile Ala Pro Gly Ala Pro Gly Pro Ala Pro Pro
    50                  55                  60                  
Ala Ser Pro Ala Ala Pro Ala Ala Pro Pro Val Ala Ser Asp Leu Gly
65                  70                  75                  80  
Pro Arg Pro Pro Val Ser Leu Asp Pro Arg Val Ser Ile Tyr Ser Thr
                85                  90                  95      
Arg Arg Pro Val Leu Ala Arg Thr His Val Gln Gly Arg Val Tyr Asn
            100                 105                 110         
Phe Leu Glu Arg Pro Thr Gly Trp Lys Cys Phe Val Tyr His Phe Ala
        115                 120                 125             
Val Phe Leu Ile Val Leu Val Cys Leu Ile Phe Ser Val Leu Ser Thr
    130                 135                 140                 
Ile Glu Gln Tyr Ala Ala Leu Ala Thr Gly Thr Leu Phe Trp Met Glu
145                 150                 155                 160 
Ile Val Leu Val Val Phe Phe Gly Thr Glu Tyr Val Val Arg Leu Trp
                165                 170                 175     
Ser Ala Gly Cys Arg Ser Lys Tyr Val Gly Leu Trp Gly Arg Leu Arg
            180                 185                 190         
Phe Ala Arg Lys Pro Ile Ser Ile Ile Asp Leu Ile Val Val Val Ala
        195                 200                 205             
Ser Met Val Val Leu Cys Val Gly Ser Lys Gly Gln Val Phe Ala Thr
    210                 215                 220                 
Ser Ala Ile Arg Gly Ile Arg Phe Leu Gln Ile Leu Arg Met Leu His
225                 230                 235                 240 
Val Asp Arg Gln Gly Gly Thr Trp Arg Leu Leu Gly Ser Val Val Phe
                245                 250                 255     
Ile His Arg Gln Glu Leu Ile Thr Thr Leu Tyr Ile Gly Phe Leu Gly
            260                 265                 270         
Leu Ile Phe Ser Ser Tyr Phe Val Tyr Leu Ala Glu Lys Asp Ala Val
        275                 280                 285             
Asn Glu Ser Gly Arg Val Glu Phe Gly Ser Tyr Ala Asp Ala Leu Trp
    290                 295                 300                 
Trp Gly Val Val Thr Val Thr Thr Ile Gly Tyr Gly Asp Lys Val Pro
305                 310                 315                 320 
Gln Thr Trp Val Gly Lys Thr Ile Ala Ser Cys Phe Ser Val Phe Ala
                325                 330                 335     
Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala
            340                 345                 350         
Leu Lys Val Gln Gln Lys Gln Arg Gln Lys His Phe Asn Arg Gln Ile
        355                 360                 365             
Pro Ala Ala Ala Ser Leu Ile Gln Thr Ala Trp Arg Cys Tyr Ala Ala
    370                 375                 380                 
Glu Asn Pro Asp Ser Ser Thr Trp Lys Ile Tyr Ile Arg Lys Ala Pro
385                 390                 395                 400 
Arg Ser His Thr Leu Leu Ser Pro Ser Pro Lys Pro Lys Lys Ser Val
                405                 410                 415     
Val Val Lys Lys Lys Lys Phe Lys Leu Asp Lys Asp Asn Gly Val Thr
            420                 425                 430         
Pro Gly Glu Lys Met Leu Thr Val Pro His Ile Thr Cys Asp Pro Pro
        435                 440                 445             
Glu Glu Arg Arg Leu Asp His Phe Ser Val Asp Gly Tyr Asp Ser Ser
    450                 455                 460                 
Val Arg Lys Ser Pro Thr Leu Leu Glu Val Ser Met Pro His Phe Met
465                 470                 475                 480 
Arg Thr Asn Ser Phe Ala Glu Asp Leu Asp Leu Glu Gly Glu Thr Leu
                485                 490                 495     
Leu Thr Pro Ile Thr His Ile Ser Gln Leu Arg Glu His His Arg Ala
            500                 505                 510         
Thr Ile Lys Val Ile Arg Arg Met Gln Tyr Phe Val Ala Lys Lys Lys
        515                 520                 525             
Phe Gln Gln Ala Arg Lys Pro Tyr Asp Val Arg Asp Val Ile Glu Gln
    530                 535                 540                 
Tyr Ser Gln Gly His Leu Asn Leu Met Val Arg Ile Lys Glu Leu Gln
545                 550                 555                 560 
Arg Arg Leu Asp Gln Ser Ile Gly Lys Pro Ser Leu Phe Ile Ser Val
                565                 570                 575     
Ser Glu Lys Ser Lys Asp Arg Gly Ser Asn Thr Ile Gly Ala Arg Leu
            580                 585                 590         
Asn Arg Val Glu Asp Lys Val Thr Gln Leu Asp Gln Arg Leu Ala Leu
        595                 600                 605             
Ile Thr Asp Met Leu His Gln Leu Leu Ser Leu His Gly Gly Ser Thr
    610                 615                 620                 
Pro Gly Ser Gly Gly Pro Pro Arg Glu Gly Gly Ala His Ile Thr Gln
625                 630                 635                 640 
Pro Cys Gly Ser Gly Gly Ser Val Asp Pro Glu Leu Phe Leu Pro Ser
                645                 650                 655     
Asn Thr Leu Pro Thr Tyr Glu Gln Leu Thr Val Pro Arg Arg Gly Pro
            660                 665                 670         
Asp Glu Gly Ser
        675     


<210> 2
<211> 676
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Ala Ala Ser Ser Pro Pro Arg Ala Glu Arg Lys Arg Trp Gly
 1               5                  10                  15      
Trp Gly Arg Leu Pro Gly Ala Arg Arg Gly Ser Ala Gly Leu Ala Lys
            20                  25                  30          
Lys Cys Pro Phe Ser Leu Glu Leu Ala Glu Gly Gly Pro Ala Gly Gly
        35                  40                  45              
Ala Leu Tyr Ala Pro Ile Ala Pro Gly Ala Pro Gly Pro Ala Pro Pro
    50                  55                  60                  
Ala Ser Pro Ala Ala Pro Ala Ala Pro Pro Val Ala Ser Asp Leu Gly
65                  70                  75                  80  
Pro Arg Pro Pro Val Ser Leu Asp Pro Arg Val Ser Ile Tyr Ser Thr
                85                  90                  95      
Arg Arg Pro Val Leu Ala Arg Thr His Val Gln Gly Arg Val Tyr Asn
            100                 105                 110         
Phe Leu Glu Arg Pro Thr Gly Trp Lys Cys Phe Val Tyr His Phe Ala
        115                 120                 125             
Val Phe Leu Ile Val Leu Val Cys Leu Ile Phe Ser Val Leu Ser Thr
    130                 135                 140                 
Ile Glu Gln Tyr Ala Ala Leu Ala Thr Gly Thr Leu Phe Trp Met Glu
145                 150                 155                 160 
Ile Val Leu Val Val Phe Phe Gly Thr Glu Tyr Val Val Arg Leu Trp
                165                 170                 175     
Ser Ala Gly Cys Arg Ser Lys Tyr Val Gly Leu Trp Gly Arg Leu Arg
            180                 185                 190         
Phe Ala Arg Lys Pro Ile Ser Ile Ile Asp Leu Ile Val Val Val Ala
        195                 200                 205             
Ser Met Val Val Leu Cys Val Gly Ser Lys Gly Gln Val Phe Ala Thr
    210                 215                 220                 
Ser Ala Ile Arg Gly Ile Arg Phe Leu Gln Ile Leu Arg Met Leu His
225                 230                 235                 240 
Val Asp Arg Gln Gly Gly Thr Trp Arg Leu Leu Gly Ser Val Val Phe
                245                 250                 255     
Ile His Arg Gln Glu Leu Ile Thr Thr Leu Tyr Ile Gly Phe Leu Gly
            260                 265                 270         
Leu Ile Phe Ser Ser Tyr Phe Val Tyr Leu Ala Glu Lys Asp Ala Val
        275                 280                 285             
Asn Glu Ser Gly Arg Val Glu Phe Gly Ser Tyr Ala Asp Ala Leu Trp
    290                 295                 300                 
Trp Gly Val Val Thr Val Thr Thr Ile Gly Tyr Gly Asp Lys Val Pro
305                 310                 315                 320 
Gln Thr Trp Val Gly Lys Thr Ile Ala Ser Cys Phe Ser Val Phe Ala
                325                 330                 335     
Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala
            340                 345                 350         
Leu Lys Val Gln Gln Lys Gln Arg Gln Lys His Phe Asn Arg Gln Ile
        355                 360                 365             
Pro Ala Ala Ala Ser Leu Ile Gln Thr Ala Trp Arg Cys Tyr Ala Ala
    370                 375                 380                 
Glu Asn Pro Asp Ser Ser Thr Trp Lys Ile Tyr Ile Arg Lys Ala Pro
385                 390                 395                 400 
Arg Ser His Thr Leu Leu Ser Pro Ser Pro Lys Pro Lys Lys Ser Val
                405                 410                 415     
Val Val Lys Lys Lys Lys Phe Lys Leu Asp Lys Asp Asn Gly Val Thr
            420                 425                 430         
Pro Gly Glu Lys Met Leu Thr Val Pro His Ile Thr Cys Asp Pro Pro
        435                 440                 445             
Glu Glu Arg Arg Leu Asp His Phe Ser Val Asp Gly Tyr Asp Ser Ser
    450                 455                 460                 
Val Arg Lys Ser Pro Thr Leu Leu Glu Val Ser Met Pro His Phe Met
465                 470                 475                 480 
Arg Thr Asn Ser Phe Ala Glu Asp Leu Asp Leu Glu Gly Glu Thr Leu
                485                 490                 495     
Leu Thr Pro Ile Thr His Ile Ser Gln Leu Arg Glu His His Arg Ala
            500                 505                 510         
Thr Ile Lys Val Ile Arg Arg Met Gln Tyr Phe Val Ala Lys Lys Lys
        515                 520                 525             
Phe Gln Gln Ala Arg Lys Pro Tyr Asp Val Arg Asp Val Ile Glu Gln
    530                 535                 540                 
Tyr Ser Gln Gly His Leu Asn Leu Met Val Arg Ile Lys Glu Leu Gln
545                 550                 555                 560 
Arg Arg Leu Asp Gln Ser Ile Gly Lys Pro Ser Leu Phe Ile Ser Val
                565                 570                 575     
Ser Glu Lys Ser Lys Asp Arg Gly Ser Asn Thr Ile Gly Ala Arg Leu
            580                 585                 590         
Asn Arg Val Glu Asp Lys Val Thr Gln Leu Asp Gln Arg Leu Ala Leu
        595                 600                 605             
Ile Thr Asp Met Leu His Gln Leu Leu Ser Leu His Gly Gly Ser Thr
    610                 615                 620                 
Pro Gly Ser Gly Gly Pro Pro Arg Glu Gly Gly Ala His Ile Thr Gln
625                 630                 635                 640 
Pro Cys Gly Ser Gly Gly Ser Val Asp Pro Glu Leu Phe Leu Pro Ser
                645                 650                 655     
Asn Thr Leu Pro Thr Tyr Glu Gln Leu Thr Val Pro Arg Arg Gly Pro
            660                 665                 670         
Asp Glu Gly Ser
        675     


<210> 3
<211> 1159
<212> PRT
<213> Homo sapiens

<400> 3
Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp
 1               5                  10                  15      
Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala
            20                  25                  30          
Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe
        35                  40                  45              
Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys
    50                  55                  60                  
Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala
65                  70                  75                  80  
Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile
                85                  90                  95      
Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val
            100                 105                 110         
Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn
        115                 120                 125             
Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp
    130                 135                 140                 
Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala
145                 150                 155                 160 
Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg
                165                 170                 175     
Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly
            180                 185                 190         
Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu
        195                 200                 205             
Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly
    210                 215                 220                 
Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro
225                 230                 235                 240 
Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu
                245                 250                 255     
Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser
            260                 265                 270         
Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile
        275                 280                 285             
Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser
    290                 295                 300                 
Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser
305                 310                 315                 320 
Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile
                325                 330                 335     
Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro
            340                 345                 350         
Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His
        355                 360                 365             
Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val
    370                 375                 380                 
Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile
385                 390                 395                 400 
Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu
                405                 410                 415     
Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu
            420                 425                 430         
Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala
        435                 440                 445             
Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile
    450                 455                 460                 
Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu
465                 470                 475                 480 
Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly
                485                 490                 495     
Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile
            500                 505                 510         
Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg
        515                 520                 525             
Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu
    530                 535                 540                 
Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile
545                 550                 555                 560 
Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln
                565                 570                 575     
Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln
            580                 585                 590         
Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys
        595                 600                 605             
Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser
    610                 615                 620                 
Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe
625                 630                 635                 640 
Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe
                645                 650                 655     
Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg
            660                 665                 670         
Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln
        675                 680                 685             
Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala
    690                 695                 700                 
Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe
705                 710                 715                 720 
Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu
                725                 730                 735     
Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg
            740                 745                 750         
Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr
        755                 760                 765             
Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg
    770                 775                 780                 
Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly
785                 790                 795                 800 
Lys Asn Asp Ile Phe Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly
                805                 810                 815     
Lys Ser Asn Gly Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys
            820                 825                 830         
Ile His Arg Asp Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe
        835                 840                 845             
Ser Asp His Phe Trp Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp
    850                 855                 860                 
Thr Asn Met Ile Pro Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly
865                 870                 875                 880 
Phe Ser Arg Gln Arg Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp
                885                 890                 895     
Lys Asp Thr Glu Gln Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg
            900                 905                 910         
Ala Gly Ala Gly Pro Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly
        915                 920                 925             
Glu Ser Pro Ser Ser Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu
    930                 935                 940                 
Gly Pro Gly Arg Ser Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser
945                 950                 955                 960 
Pro Arg Pro Pro Gly Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp
                965                 970                 975     
Cys Glu Lys Ser Ser Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser
            980                 985                 990         
Gly Val Ser Asn Ile Phe Ser Phe Trp Gly Asp Ser Arg Gly Arg Gln
        995                 1000                1005            
Tyr Gln Glu Leu Pro Arg Cys Pro Ala Pro Thr Pro Ser Leu Leu Asn
    1010                1015                1020                
Ile Pro Leu Ser Ser Pro Gly Arg Arg Pro Arg Gly Asp Val Glu Ser
1025                1030                1035                1040
Arg Leu Asp Ala Leu Gln Arg Gln Leu Asn Arg Leu Glu Thr Arg Leu
                1045                1050                1055    
Ser Ala Asp Met Ala Thr Val Leu Gln Leu Leu Gln Arg Gln Met Thr
            1060                1065                1070        
Leu Val Pro Pro Ala Tyr Ser Ala Val Thr Thr Pro Gly Pro Gly Pro
        1075                1080                1085            
Thr Ser Thr Ser Pro Leu Leu Pro Val Ser Pro Leu Pro Thr Leu Thr
    1090                1095                1100                
Leu Asp Ser Leu Ser Gln Val Ser Gln Phe Met Ala Cys Glu Glu Leu
1105                1110                1115                1120
Pro Pro Gly Ala Pro Glu Leu Pro Gln Glu Gly Pro Thr Arg Arg Leu
                1125                1130                1135    
Ser Leu Pro Gly Gln Leu Gly Ala Leu Thr Ser Gln Pro Leu His Arg
            1140                1145                1150        
His Gly Ser Asp Pro Gly Ser
        1155                


<210> 4
<211> 2016
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe
 1               5                  10                  15      
Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln
            20                  25                  30          
Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu
        35                  40                  45              
Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu
    50                  55                  60                  
Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu
65                  70                  75                  80  
Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu
                85                  90                  95      
Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr
            100                 105                 110         
Val Leu Ser Pro Phe His Pro Val Arg Arg Ala Ala Val Lys Ile Leu
        115                 120                 125             
Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn
    130                 135                 140                 
Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val
145                 150                 155                 160 
Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile
                165                 170                 175     
Leu Ala Arg Ala Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro
            180                 185                 190         
Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu
        195                 200                 205             
Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu
    210                 215                 220                 
Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val
225                 230                 235                 240 
Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu
                245                 250                 255     
Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe
            260                 265                 270         
Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn
        275                 280                 285             
Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu
    290                 295                 300                 
Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr
305                 310                 315                 320 
Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro
                325                 330                 335     
Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr
            340                 345                 350         
Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu
        355                 360                 365             
Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser
    370                 375                 380                 
Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly
385                 390                 395                 400 
Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr
                405                 410                 415     
Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys
            420                 425                 430         
Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu
        435                 440                 445             
Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser
    450                 455                 460                 
Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys
465                 470                 475                 480 
Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys
                485                 490                 495     
Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr
            500                 505                 510         
Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser
        515                 520                 525             
Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala
    530                 535                 540                 
Asp Asp Glu Asn Ser Thr Ala Arg Glu Ser Glu Ser His His Thr Ser
545                 550                 555                 560 
Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro
                565                 570                 575     
Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn
            580                 585                 590         
Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp
        595                 600                 605             
Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu
    610                 615                 620                 
Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro
625                 630                 635                 640 
Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro
                645                 650                 655     
Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala
            660                 665                 670         
Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn
        675                 680                 685             
Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met
    690                 695                 700                 
Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp
705                 710                 715                 720 
Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu
                725                 730                 735     
Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly
            740                 745                 750         
Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile
        755                 760                 765             
Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe
    770                 775                 780                 
Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg
785                 790                 795                 800 
Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe
                805                 810                 815     
Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile
            820                 825                 830         
Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile
        835                 840                 845             
Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn
    850                 855                 860                 
Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His
865                 870                 875                 880 
Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys
                885                 890                 895     
Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln
            900                 905                 910         
Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu
        915                 920                 925             
Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala
    930                 935                 940                 
Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln
945                 950                 955                 960 
Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr
                965                 970                 975     
Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg His Arg Pro Gln Lys Pro
            980                 985                 990         
Ala Ala Leu Ala Ala Gln Gly Gln Leu Pro Ser Cys Ile Ala Thr Pro
        995                 1000                1005            
Tyr Ser Pro Pro Pro Pro Glu Thr Glu Lys Val Pro Pro Thr Arg Lys
    1010                1015                1020                
Glu Thr Gln Phe Glu Glu Gly Glu Gln Pro Gly Gln Gly Thr Pro Gly
1025                1030                1035                1040
Asp Pro Glu Pro Val Cys Val Pro Ile Ala Val Ala Glu Ser Asp Thr
                1045                1050                1055    
Asp Asp Gln Glu Glu Asp Glu Glu Asn Ser Leu Gly Thr Glu Glu Glu
            1060                1065                1070        
Ser Ser Lys Gln Gln Glu Ser Gln Pro Val Ser Gly Trp Pro Arg Gly
        1075                1080                1085            
Pro Pro Asp Ser Arg Thr Trp Ser Gln Val Ser Ala Thr Ala Ser Ser
    1090                1095                1100                
Glu Ala Glu Ala Ser Ala Ser Gln Ala Asp Trp Arg Gln Gln Trp Lys
1105                1110                1115                1120
Ala Glu Pro Gln Ala Pro Gly Cys Gly Glu Thr Pro Glu Asp Ser Cys
                1125                1130                1135    
Ser Glu Gly Ser Thr Ala Asp Met Thr Asn Thr Ala Glu Leu Leu Glu
            1140                1145                1150        
Gln Ile Pro Asp Leu Gly Gln Asp Val Lys Asp Pro Glu Asp Cys Phe
        1155                1160                1165            
Thr Glu Gly Cys Val Arg Arg Cys Pro Cys Cys Ala Val Asp Thr Thr
    1170                1175                1180                
Gln Ala Pro Gly Lys Val Trp Trp Arg Leu Arg Lys Thr Cys Tyr His
1185                1190                1195                1200
Ile Val Glu His Ser Trp Phe Glu Thr Phe Ile Ile Phe Met Ile Leu
                1205                1210                1215    
Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Leu Glu Glu Arg
            1220                1225                1230        
Lys Thr Ile Lys Val Leu Leu Glu Tyr Ala Asp Lys Met Phe Thr Tyr
        1235                1240                1245            
Val Phe Val Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Phe Lys
    1250                1255                1260                
Lys Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile Val Asp
1265                1270                1275                1280
Val Ser Leu Val Ser Leu Val Ala Asn Thr Leu Gly Phe Ala Glu Met
                1285                1290                1295    
Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg
            1300                1305                1310        
Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala Leu Val
        1315                1320                1325            
Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile Phe
    1330                1335                1340                
Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys Phe
1345                1350                1355                1360
Gly Arg Cys Ile Asn Gln Thr Glu Gly Asp Leu Pro Leu Asn Tyr Thr
                1365                1370                1375    
Ile Val Asn Asn Lys Ser Gln Cys Glu Ser Leu Asn Leu Thr Gly Glu
            1380                1385                1390        
Leu Tyr Trp Thr Lys Val Lys Val Asn Phe Asp Asn Val Gly Ala Gly
        1395                1400                1405            
Tyr Leu Ala Leu Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp Ile
    1410                1415                1420                
Met Tyr Ala Ala Val Asp Ser Arg Gly Tyr Glu Glu Gln Pro Gln Trp
1425                1430                1435                1440
Glu Tyr Asn Leu Tyr Met Tyr Ile Tyr Phe Val Ile Phe Ile Ile Phe
                1445                1450                1455    
Gly Ser Phe Phe Thr Leu Asn Leu Phe Ile Gly Val Ile Ile Asp Asn
            1460                1465                1470        
Phe Asn Gln Gln Lys Lys Lys Leu Gly Gly Gln Asp Ile Phe Met Thr
        1475                1480                1485            
Glu Glu Gln Lys Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser Lys
    1490                1495                1500                
Lys Pro Gln Lys Pro Ile Pro Arg Pro Leu Asn Lys Tyr Gln Gly Phe
1505                1510                1515                1520
Ile Phe Asp Ile Val Thr Lys Gln Ala Phe Asp Val Thr Ile Met Phe
                1525                1530                1535    
Leu Ile Cys Leu Asn Met Val Thr Met Met Val Glu Thr Asp Asp Gln
            1540                1545                1550        
Ser Pro Glu Lys Ile Asn Ile Leu Ala Lys Ile Asn Leu Leu Phe Val
        1555                1560                1565            
Ala Ile Phe Thr Gly Glu Cys Ile Val Lys Leu Ala Ala Leu Arg His
    1570                1575                1580                
Tyr Tyr Phe Thr Asn Ser Trp Asn Ile Phe Asp Phe Val Val Val Ile
1585                1590                1595                1600
Leu Ser Ile Val Gly Thr Val Leu Ser Asp Ile Ile Gln Lys Tyr Phe
                1605                1610                1615    
Phe Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly Arg
            1620                1625                1630        
Ile Leu Arg Leu Ile Arg Gly Ala Lys Gly Ile Arg Thr Leu Leu Phe
        1635                1640                1645            
Ala Leu Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu Leu
    1650                1655                1660                
Phe Leu Val Met Phe Ile Tyr Ser Ile Phe Gly Met Ala Asn Phe Ala
1665                1670                1675                1680
Tyr Val Lys Trp Glu Ala Gly Ile Asp Asp Met Phe Asn Phe Gln Thr
                1685                1690                1695    
Phe Ala Asn Ser Met Leu Cys Leu Phe Gln Ile Thr Thr Ser Ala Gly
            1700                1705                1710        
Trp Asp Gly Leu Leu Ser Pro Ile Leu Asn Thr Gly Pro Pro Tyr Cys
        1715                1720                1725            
Asp Pro Thr Leu Pro Asn Ser Asn Gly Ser Arg Gly Asp Cys Gly Ser
    1730                1735                1740                
Pro Ala Val Gly Ile Leu Phe Phe Thr Thr Tyr Ile Ile Ile Ser Phe
1745                1750                1755                1760
Leu Ile Val Val Asn Met Tyr Ile Ala Ile Ile Leu Glu Asn Phe Ser
                1765                1770                1775    
Val Ala Thr Glu Glu Ser Thr Glu Pro Leu Ser Glu Asp Asp Phe Asp
            1780                1785                1790        
Met Phe Tyr Glu Ile Trp Glu Lys Phe Asp Pro Glu Ala Thr Gln Phe
        1795                1800                1805            
Ile Glu Tyr Ser Val Leu Ser Asp Phe Ala Asp Ala Leu Ser Glu Pro
    1810                1815                1820                
Leu Arg Ile Ala Lys Pro Asn Gln Ile Ser Leu Ile Asn Met Asp Leu
1825                1830                1835                1840
Pro Met Val Ser Gly Asp Arg Ile His Cys Met Asp Ile Leu Phe Ala
                1845                1850                1855    
Phe Thr Lys Arg Val Leu Gly Glu Ser Gly Glu Met Asp Ala Leu Lys
            1860                1865                1870        
Ile Gln Met Glu Glu Lys Phe Met Ala Ala Asn Pro Ser Lys Ile Ser
        1875                1880                1885            
Tyr Glu Pro Ile Thr Thr Thr Leu Arg Arg Lys His Glu Glu Val Ser
    1890                1895                1900                
Ala Met Val Ile Gln Arg Ala Phe Arg Arg His Leu Leu Gln Arg Ser
1905                1910                1915                1920
Leu Lys His Ala Ser Phe Leu Phe Arg Gln Gln Ala Gly Ser Gly Leu
                1925                1930                1935    
Ser Glu Glu Asp Ala Pro Glu Arg Glu Gly Leu Ile Ala Tyr Val Met
            1940                1945                1950        
Ser Glu Asn Phe Ser Arg Pro Leu Gly Pro Pro Ser Ser Ser Ser Ile
        1955                1960                1965            
Ser Ser Thr Ser Phe Pro Pro Ser Tyr Asp Ser Val Thr Arg Ala Thr
    1970                1975                1980                
Ser Asp Asn Leu Gln Val Arg Gly Ser Asp Tyr Ser His Ser Glu Asp
1985                1990                1995                2000
Leu Ala Asp Phe Pro Pro Ser Pro Asp Arg Asp Arg Glu Ser Ile Val
                2005                2010                2015    


<210> 5
<211> 3957
<212> PRT
<213> Homo sapiens

<400> 5
Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe
 1               5                  10                  15      
Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn
            20                  25                  30          
Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val
        35                  40                  45              
Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly
    50                  55                  60                  
Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val
65                  70                  75                  80  
Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys
                85                  90                  95      
Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val
            100                 105                 110         
Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln
        115                 120                 125             
Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp
    130                 135                 140                 
Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr
145                 150                 155                 160 
Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn
                165                 170                 175     
Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg
            180                 185                 190         
Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala
        195                 200                 205             
Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met
    210                 215                 220                 
Met Val Asn Arg Thr Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala
225                 230                 235                 240 
Ala His Tyr Gly Asn Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly
                245                 250                 255     
Ala Ala Val Asp Phe Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val
            260                 265                 270         
Ala Ser Lys Arg Gly Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg
        275                 280                 285             
Gly Gly Gln Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His
    290                 295                 300                 
Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu
305                 310                 315                 320 
Arg Gly Ala Pro Leu Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu
                325                 330                 335     
His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu
            340                 345                 350         
Gln His Lys Ala Pro Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala
        355                 360                 365             
Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Thr Lys Leu Leu
    370                 375                 380                 
Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr
385                 390                 395                 400 
Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu
                405                 410                 415     
Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu
            420                 425                 430         
Thr Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu
        435                 440                 445             
Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly
    450                 455                 460                 
Glu Thr Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val
465                 470                 475                 480 
Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu
                485                 490                 495     
Glu Gln Thr Pro Leu His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile
            500                 505                 510         
Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Thr Thr
        515                 520                 525             
Asn Gly Tyr Thr Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp
    530                 535                 540                 
Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr
545                 550                 555                 560 
Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu
                565                 570                 575     
Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala
            580                 585                 590         
Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala Ala His Tyr Asp Asn
        595                 600                 605             
Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala
    610                 615                 620                 
Thr Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn
625                 630                 635                 640 
Gln Met Gln Ile Ala Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn
                645                 650                 655     
Ile Val Thr Lys Gln Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu
            660                 665                 670         
Gly His Thr Asp Met Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile
        675                 680                 685             
His Met Ser Thr Lys Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln
    690                 695                 700                 
Glu Asp Lys Val Asn Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp
705                 710                 715                 720 
Gln Asp Ala His Thr Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys
                725                 730                 735     
His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala
            740                 745                 750         
Asn Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala
        755                 760                 765             
Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln His Gly
    770                 775                 780                 
Ala Lys Pro Asn Ala Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile
785                 790                 795                 800 
Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val
                805                 810                 815     
Thr Glu Glu Val Thr Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys
            820                 825                 830         
Leu Asn Val Pro Glu Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu
        835                 840                 845             
Glu Gly Asp Asp Thr Met Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro
    850                 855                 860                 
Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe
865                 870                 875                 880 
Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser
                885                 890                 895     
Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Thr Leu Ser His
            900                 905                 910         
Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile
        915                 920                 925             
Pro Ser His Gln Val Ser Thr Leu Ala Lys Glu Ala Glu Arg Asn Ser
    930                 935                 940                 
Tyr Arg Leu Ser Trp Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser
945                 950                 955                 960 
Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala
                965                 970                 975     
Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile
            980                 985                 990         
Ile Pro Pro Arg Lys Cys Thr Ala Pro Thr Arg Val Thr Cys Arg Leu
        995                 1000                1005            
Val Lys Arg His Arg Leu Ala Thr Met Pro Pro Met Val Glu Gly Glu
    1010                1015                1020                
Gly Leu Ala Ser Arg Leu Ile Glu Val Gly Pro Ser Gly Ala Gln Phe
1025                1030                1035                1040
Leu Gly Lys Leu His Leu Pro Thr Ala Pro Pro Pro Leu Asn Glu Gly
                1045                1050                1055    
Glu Ser Leu Val Ser Arg Ile Leu Gln Leu Gly Pro Pro Gly Thr Lys
            1060                1065                1070        
Phe Leu Gly Pro Val Ile Val Glu Ile Pro His Phe Ala Ala Leu Arg
        1075                1080                1085            
Gly Lys Glu Arg Glu Leu Val Val Leu Arg Ser Glu Asn Gly Asp Ser
    1090                1095                1100                
Trp Lys Glu His Phe Cys Asp Tyr Thr Glu Asp Glu Leu Asn Glu Ile
1105                1110                1115                1120
Leu Asn Gly Met Asp Glu Val Leu Asp Ser Pro Glu Asp Leu Glu Lys
                1125                1130                1135    
Lys Arg Ile Cys Arg Ile Ile Thr Arg Asp Phe Pro Gln Tyr Phe Ala
            1140                1145                1150        
Val Val Ser Arg Ile Lys Gln Asp Ser Asn Leu Ile Gly Pro Glu Gly
        1155                1160                1165            
Gly Val Leu Ser Ser Thr Val Val Pro Gln Val Gln Ala Val Phe Pro
    1170                1175                1180                
Glu Gly Ala Leu Thr Lys Arg Ile Arg Val Gly Leu Gln Ala Gln Pro
1185                1190                1195                1200
Met His Ser Glu Leu Val Lys Lys Ile Leu Gly Asn Lys Ala Thr Phe
                1205                1210                1215    
Ser Pro Ile Val Thr Leu Glu Pro Arg Arg Arg Lys Phe His Lys Pro
            1220                1225                1230        
Ile Thr Met Thr Ile Pro Val Pro Lys Ala Ser Ser Asp Val Met Leu
        1235                1240                1245            
Asn Gly Phe Gly Gly Asp Ala Pro Thr Leu Arg Leu Leu Cys Ser Ile
    1250                1255                1260                
Thr Gly Gly Thr Thr Pro Ala Gln Trp Glu Asp Ile Thr Gly Thr Thr
1265                1270                1275                1280
Pro Leu Thr Phe Val Asn Glu Cys Val Ser Phe Thr Thr Asn Val Ser
                1285                1290                1295    
Ala Arg Phe Trp Leu Ile Asp Cys Arg Gln Ile Gln Glu Ser Val Thr
            1300                1305                1310        
Phe Ala Ser Gln Val Tyr Arg Glu Ile Ile Cys Val Pro Tyr Met Ala
        1315                1320                1325            
Lys Phe Val Val Phe Ala Lys Ser His Asp Pro Ile Glu Ala Arg Leu
    1330                1335                1340                
Arg Cys Phe Cys Met Thr Asp Asp Lys Val Asp Lys Thr Leu Glu Gln
1345                1350                1355                1360
Gln Glu Asn Phe Ala Glu Val Ala Arg Ser Arg Asp Val Glu Val Leu
                1365                1370                1375    
Glu Gly Lys Pro Ile Tyr Val Asp Cys Phe Gly Asn Leu Val Pro Leu
            1380                1385                1390        
Thr Lys Ser Gly Gln His His Ile Phe Ser Phe Phe Ala Phe Lys Glu
        1395                1400                1405            
Asn Arg Leu Pro Leu Phe Val Lys Val Arg Asp Thr Thr Gln Glu Pro
    1410                1415                1420                
Cys Gly Arg Leu Ser Phe Met Lys Glu Pro Lys Ser Thr Arg Gly Leu
1425                1430                1435                1440
Val His Gln Ala Ile Cys Asn Leu Asn Ile Thr Leu Pro Ile Tyr Thr
                1445                1450                1455    
Lys Glu Ser Glu Ser Asp Gln Glu Gln Glu Glu Glu Ile Asp Met Thr
            1460                1465                1470        
Ser Glu Lys Asn Asp Glu Thr Glu Ser Thr Glu Thr Ser Val Leu Lys
        1475                1480                1485            
Ser His Leu Val Asn Glu Val Pro Val Leu Ala Ser Pro Asp Leu Leu
    1490                1495                1500                
Ser Glu Val Ser Glu Met Lys Gln Asp Leu Ile Lys Met Thr Ala Ile
1505                1510                1515                1520
Leu Thr Thr Asp Val Ser Asp Lys Ala Gly Ser Ile Lys Val Lys Glu
                1525                1530                1535    
Leu Val Lys Ala Ala Glu Glu Glu Pro Gly Glu Pro Phe Glu Ile Val
            1540                1545                1550        
Glu Arg Val Lys Glu Asp Leu Glu Lys Val Asn Glu Ile Leu Arg Ser
        1555                1560                1565            
Gly Thr Cys Thr Arg Asp Glu Ser Ser Val Gln Ser Ser Arg Ser Glu
    1570                1575                1580                
Arg Gly Leu Val Glu Glu Glu Trp Val Ile Val Ser Asp Glu Glu Ile
1585                1590                1595                1600
Glu Glu Ala Arg Gln Lys Ala Pro Leu Glu Ile Thr Glu Tyr Pro Cys
                1605                1610                1615    
Val Glu Val Arg Ile Asp Lys Glu Ile Lys Gly Lys Val Glu Lys Asp
            1620                1625                1630        
Ser Thr Gly Leu Val Asn Tyr Leu Thr Asp Asp Leu Asn Thr Cys Val
        1635                1640                1645            
Pro Leu Pro Lys Glu Gln Leu Gln Thr Val Gln Asp Lys Ala Gly Lys
    1650                1655                1660                
Lys Cys Glu Ala Leu Ala Val Gly Arg Ser Ser Glu Lys Glu Gly Lys
1665                1670                1675                1680
Asp Ile Pro Pro Asp Glu Thr Gln Ser Thr Gln Lys Gln His Lys Pro
                1685                1690                1695    
Ser Leu Gly Ile Lys Lys Pro Val Arg Arg Lys Leu Lys Glu Lys Gln
            1700                1705                1710        
Lys Gln Lys Glu Glu Gly Leu Gln Ala Ser Ala Glu Lys Ala Glu Leu
        1715                1720                1725            
Lys Lys Gly Ser Ser Glu Glu Ser Leu Gly Glu Asp Pro Gly Leu Ala
    1730                1735                1740                
Pro Glu Pro Leu Pro Thr Val Lys Ala Thr Ser Pro Leu Ile Glu Glu
1745                1750                1755                1760
Thr Pro Ile Gly Ser Ile Lys Asp Lys Val Lys Ala Leu Gln Lys Arg
                1765                1770                1775    
Val Glu Asp Glu Gln Lys Gly Arg Ser Lys Leu Pro Ile Arg Val Lys
            1780                1785                1790        
Gly Lys Glu Asp Val Pro Lys Lys Thr Thr His Arg Pro His Pro Ala
        1795                1800                1805            
Ala Ser Pro Ser Leu Lys Ser Glu Arg His Ala Pro Gly Ser Pro Ser
    1810                1815                1820                
Pro Lys Thr Glu Arg His Ser Thr Leu Ser Ser Ser Ala Lys Thr Glu
1825                1830                1835                1840
Arg His Pro Pro Val Ser Pro Ser Ser Lys Thr Glu Lys His Ser Pro
                1845                1850                1855    
Val Ser Pro Ser Ala Lys Thr Glu Arg His Ser Pro Ala Ser Ser Ser
            1860                1865                1870        
Ser Lys Thr Glu Lys His Ser Pro Val Ser Pro Ser Thr Lys Thr Glu
        1875                1880                1885            
Arg His Ser Pro Val Ser Ser Thr Lys Thr Glu Arg His Pro Pro Val
    1890                1895                1900                
Ser Pro Ser Gly Lys Thr Asp Lys Arg Pro Pro Val Ser Pro Ser Gly
1905                1910                1915                1920
Arg Thr Glu Lys His Pro Pro Val Ser Pro Gly Arg Thr Glu Lys Arg
                1925                1930                1935    
Leu Pro Val Ser Pro Ser Gly Arg Thr Asp Lys His Gln Pro Val Ser
            1940                1945                1950        
Thr Ala Gly Lys Thr Glu Lys His Leu Pro Val Ser Pro Ser Gly Lys
        1955                1960                1965            
Thr Glu Lys Gln Pro Pro Val Ser Pro Thr Ser Lys Thr Glu Arg Ile
    1970                1975                1980                
Glu Glu Thr Met Ser Val Arg Glu Leu Met Lys Ala Phe Gln Ser Gly
1985                1990                1995                2000
Gln Asp Pro Ser Lys His Lys Thr Gly Leu Phe Glu His Lys Ser Ala
                2005                2010                2015    
Lys Gln Lys Gln Pro Gln Glu Lys Gly Lys Val Arg Val Glu Lys Glu
            2020                2025                2030        
Lys Gly Pro Ile Leu Thr Gln Arg Glu Ala Gln Lys Thr Glu Asn Gln
        2035                2040                2045            
Thr Ile Lys Arg Gly Gln Arg Leu Pro Val Thr Gly Thr Ala Glu Ser
    2050                2055                2060                
Lys Arg Gly Val Arg Val Ser Ser Ile Gly Val Lys Lys Glu Asp Ala
2065                2070                2075                2080
Ala Gly Gly Lys Glu Lys Val Leu Ser His Lys Ile Pro Glu Pro Val
                2085                2090                2095    
Gln Ser Val Pro Glu Glu Glu Ser His Arg Glu Ser Glu Val Pro Lys
            2100                2105                2110        
Glu Lys Met Ala Asp Glu Gln Gly Asp Met Asp Leu Gln Ile Ser Pro
        2115                2120                2125            
Asp Arg Lys Thr Ser Thr Asp Phe Ser Glu Val Ile Lys Gln Glu Leu
    2130                2135                2140                
Glu Asp Asn Asp Lys Tyr Gln Gln Phe Arg Leu Ser Glu Glu Thr Glu
2145                2150                2155                2160
Lys Ala Gln Leu His Leu Asp Gln Val Leu Thr Ser Pro Phe Asn Thr
                2165                2170                2175    
Thr Phe Pro Leu Asp Tyr Met Lys Asp Glu Phe Leu Pro Ala Leu Ser
            2180                2185                2190        
Leu Gln Ser Gly Ala Leu Asp Gly Ser Ser Glu Ser Leu Lys Asn Glu
        2195                2200                2205            
Gly Val Ala Gly Ser Pro Cys Gly Ser Leu Met Glu Gly Thr Pro Gln
    2210                2215                2220                
Ile Ser Ser Glu Glu Ser Tyr Lys His Glu Gly Leu Ala Glu Thr Pro
2225                2230                2235                2240
Glu Thr Ser Pro Glu Ser Leu Ser Phe Ser Pro Lys Lys Ser Glu Glu
                2245                2250                2255    
Gln Thr Gly Glu Thr Lys Glu Ser Thr Lys Thr Glu Thr Thr Thr Glu
            2260                2265                2270        
Ile Arg Ser Glu Lys Glu His Pro Thr Thr Lys Asp Ile Thr Gly Gly
        2275                2280                2285            
Ser Glu Glu Arg Gly Ala Thr Val Thr Glu Asp Ser Glu Thr Ser Thr
    2290                2295                2300                
Glu Ser Phe Gln Lys Glu Ala Thr Leu Gly Ser Pro Lys Asp Thr Ser
2305                2310                2315                2320
Pro Lys Arg Gln Asp Asp Cys Thr Gly Ser Cys Ser Val Ala Leu Ala
                2325                2330                2335    
Lys Glu Thr Pro Thr Gly Leu Thr Glu Glu Ala Ala Cys Asp Glu Gly
            2340                2345                2350        
Gln Arg Thr Phe Gly Ser Ser Ala His Lys Thr Gln Thr Asp Ser Glu
        2355                2360                2365            
Val Gln Glu Ser Thr Ala Thr Ser Asp Glu Thr Lys Ala Leu Pro Leu
    2370                2375                2380                
Pro Glu Ala Ser Val Lys Thr Asp Thr Gly Thr Glu Ser Lys Pro Gln
2385                2390                2395                2400
Gly Val Ile Arg Ser Pro Gln Gly Leu Glu Leu Ala Leu Pro Ser Arg
                2405                2410                2415    
Asp Ser Glu Val Leu Ser Ala Val Ala Asp Asp Ser Leu Ala Val Ser
            2420                2425                2430        
His Lys Asp Ser Leu Glu Ala Ser Pro Val Leu Glu Asp Asn Ser Ser
        2435                2440                2445            
His Lys Thr Pro Asp Ser Leu Glu Pro Ser Pro Leu Lys Glu Ser Pro
    2450                2455                2460                
Cys Arg Asp Ser Leu Glu Ser Ser Pro Val Glu Pro Lys Met Lys Ala
2465                2470                2475                2480
Gly Ile Phe Pro Ser His Phe Pro Leu Pro Ala Ala Val Ala Lys Thr
                2485                2490                2495    
Glu Leu Leu Thr Glu Val Ala Ser Val Arg Ser Arg Leu Leu Arg Asp
            2500                2505                2510        
Pro Asp Gly Ser Ala Glu Asp Asp Ser Leu Glu Gln Thr Ser Leu Met
        2515                2520                2525            
Glu Ser Ser Gly Lys Ser Pro Leu Ser Pro Asp Thr Pro Ser Ser Glu
    2530                2535                2540                
Glu Val Ser Tyr Glu Val Thr Pro Lys Thr Thr Asp Val Ser Thr Pro
2545                2550                2555                2560
Lys Pro Ala Val Ile His Glu Cys Ala Glu Glu Asp Asp Ser Glu Asn
                2565                2570                2575    
Gly Glu Lys Lys Arg Phe Thr Pro Glu Glu Glu Met Phe Lys Met Val
            2580                2585                2590        
Thr Lys Ile Lys Met Phe Asp Glu Leu Glu Gln Glu Ala Lys Gln Lys
        2595                2600                2605            
Arg Asp Tyr Lys Lys Glu Pro Lys Gln Glu Glu Ser Ser Ser Ser Ser
    2610                2615                2620                
Asp Pro Asp Ala Asp Cys Ser Val Asp Val Asp Glu Pro Lys His Thr
2625                2630                2635                2640
Gly Ser Gly Glu Asp Glu Ser Gly Val Pro Val Leu Val Thr Ser Glu
                2645                2650                2655    
Ser Arg Lys Val Ser Ser Ser Ser Glu Ser Glu Pro Glu Leu Ala Gln
            2660                2665                2670        
Leu Lys Lys Gly Ala Asp Ser Gly Leu Leu Pro Glu Pro Val Ile Arg
        2675                2680                2685            
Val Gln Pro Pro Ser Pro Leu Pro Ser Ser Met Asp Ser Asn Ser Ser
    2690                2695                2700                
Pro Glu Glu Val Gln Phe Gln Pro Val Val Ser Lys Gln Tyr Thr Phe
2705                2710                2715                2720
Lys Met Asn Glu Asp Thr Gln Glu Glu Pro Gly Lys Ser Glu Glu Glu
                2725                2730                2735    
Lys Asp Ser Glu Ser His Leu Ala Glu Asp Arg His Ala Val Ser Thr
            2740                2745                2750        
Glu Ala Glu Asp Arg Ser Tyr Asp Lys Leu Asn Arg Asp Thr Asp Gln
        2755                2760                2765            
Pro Lys Ile Cys Asp Gly His Gly Cys Glu Ala Met Ser Pro Ser Ser
    2770                2775                2780                
Ser Ala Ala Pro Val Ser Ser Gly Leu Gln Ser Pro Thr Gly Asp Asp
2785                2790                2795                2800
Val Asp Glu Gln Pro Val Ile Tyr Lys Glu Ser Leu Ala Leu Gln Gly
                2805                2810                2815    
Thr His Glu Lys Asp Thr Glu Gly Glu Glu Leu Asp Val Ser Arg Ala
            2820                2825                2830        
Glu Ser Pro Gln Ala Asp Cys Pro Ser Glu Ser Phe Ser Ser Ser Ser
        2835                2840                2845            
Ser Leu Pro His Cys Leu Val Ser Glu Gly Lys Glu Leu Asp Glu Asp
    2850                2855                2860                
Ile Ser Ala Thr Ser Ser Ile Gln Lys Thr Glu Val Thr Lys Thr Asp
2865                2870                2875                2880
Glu Thr Phe Glu Asn Leu Pro Lys Asp Cys Pro Ser Gln Asp Ser Ser
                2885                2890                2895    
Ile Thr Thr Gln Thr Asp Arg Phe Ser Met Asp Val Pro Val Ser Asp
            2900                2905                2910        
Leu Ala Glu Asn Asp Glu Ile Tyr Asp Pro Gln Ile Thr Ser Pro Tyr
        2915                2920                2925            
Glu Asn Val Pro Ser Gln Ser Phe Phe Ser Ser Glu Glu Ser Lys Thr
    2930                2935                2940                
Gln Thr Asp Ala Asn His Thr Thr Ser Phe His Ser Ser Glu Val Tyr
2945                2950                2955                2960
Ser Val Thr Ile Thr Ser Pro Val Glu Asp Val Val Val Ala Ser Ser
                2965                2970                2975    
Ser Ser Gly Thr Val Leu Ser Lys Glu Ser Asn Phe Glu Gly Gln Asp
            2980                2985                2990        
Ile Lys Met Glu Ser Gln Gln Glu Ser Thr Leu Trp Glu Met Gln Ser
        2995                3000                3005            
Asp Ser Val Ser Ser Ser Phe Glu Pro Thr Met Ser Ala Thr Thr Thr
    3010                3015                3020                
Val Val Gly Glu Gln Ile Ser Lys Val Ile Ile Thr Lys Thr Asp Val
3025                3030                3035                3040
Asp Ser Asp Ser Trp Ser Glu Ile Arg Glu Asp Asp Glu Ala Phe Glu
                3045                3050                3055    
Ala Arg Val Lys Glu Glu Glu Gln Lys Ile Phe Gly Leu Met Val Asp
            3060                3065                3070        
Arg Gln Ser Gln Gly Thr Thr Pro Asp Thr Thr Pro Ala Arg Thr Pro
        3075                3080                3085            
Thr Glu Glu Gly Thr Pro Thr Ser Glu Gln Asn Pro Phe Leu Phe Gln
    3090                3095                3100                
Glu Gly Lys Leu Phe Glu Met Thr Arg Ser Gly Ala Ile Asp Met Thr
3105                3110                3115                3120
Lys Arg Ser Tyr Ala Asp Glu Ser Phe His Phe Phe Gln Ile Gly Gln
                3125                3130                3135    
Glu Ser Arg Glu Glu Thr Leu Ser Glu Asp Val Lys Glu Gly Ala Thr
            3140                3145                3150        
Gly Ala Asp Pro Leu Pro Leu Glu Thr Ser Ala Glu Ser Leu Ala Leu
        3155                3160                3165            
Ser Glu Ser Lys Glu Thr Val Asp Asp Glu Ala Asp Leu Leu Pro Asp
    3170                3175                3180                
Asp Val Ser Glu Glu Val Glu Glu Ile Pro Ala Ser Asp Ala Gln Leu
3185                3190                3195                3200
Asn Ser Gln Met Gly Ile Ser Ala Ser Thr Glu Thr Pro Thr Lys Glu
                3205                3210                3215    
Ala Val Ser Val Gly Thr Lys Asp Leu Pro Thr Val Gln Thr Gly Asp
            3220                3225                3230        
Ile Pro Pro Leu Ser Gly Val Lys Gln Ile Ser Cys Pro Asp Ser Ser
        3235                3240                3245            
Glu Pro Ala Val Gln Val Gln Leu Asp Phe Ser Thr Leu Thr Arg Ser
    3250                3255                3260                
Val Tyr Ser Asp Arg Gly Asp Asp Ser Pro Asp Ser Ser Pro Glu Glu
3265                3270                3275                3280
Gln Lys Ser Val Ile Glu Ile Pro Thr Ala Pro Met Glu Asn Val Pro
                3285                3290                3295    
Phe Thr Glu Ser Lys Ser Lys Ile Pro Val Arg Thr Met Pro Thr Ser
            3300                3305                3310        
Thr Pro Ala Pro Pro Ser Ala Glu Tyr Glu Ser Ser Val Ser Glu Asp
        3315                3320                3325            
Phe Leu Ser Ser Val Asp Glu Glu Asn Lys Ala Asp Glu Ala Lys Pro
    3330                3335                3340                
Lys Ser Lys Leu Pro Val Lys Val Pro Leu Gln Arg Val Glu Gln Gln
3345                3350                3355                3360
Leu Ser Asp Leu Asp Thr Ser Val Gln Lys Thr Val Ala Pro Gln Gly
                3365                3370                3375    
Gln Asp Met Ala Ser Ile Ala Pro Asp Asn Arg Ser Lys Ser Glu Ser
            3380                3385                3390        
Asp Ala Ser Ser Leu Asp Ser Lys Thr Lys Cys Pro Val Lys Thr Arg
        3395                3400                3405            
Ser Tyr Thr Glu Thr Glu Thr Glu Ser Arg Glu Arg Ala Glu Glu Leu
    3410                3415                3420                
Glu Leu Glu Ser Glu Glu Gly Ala Thr Arg Pro Lys Ile Leu Thr Ser
3425                3430                3435                3440
Arg Leu Pro Val Lys Ser Arg Ser Thr Thr Ser Ser Cys Arg Gly Gly
                3445                3450                3455    
Thr Ser Pro Thr Lys Glu Ser Lys Glu His Phe Phe Asp Leu Tyr Arg
            3460                3465                3470        
Asn Ser Ile Glu Phe Phe Glu Glu Ile Ser Asp Glu Ala Ser Lys Leu
        3475                3480                3485            
Val Asp Arg Leu Thr Gln Ser Glu Arg Glu Gln Glu Ile Val Ser Asp
    3490                3495                3500                
Asp Glu Ser Ser Ser Ala Leu Glu Val Ser Val Ile Glu Asn Leu Pro
3505                3510                3515                3520
Pro Val Glu Thr Glu His Ser Val Pro Glu Asp Ile Phe Asp Thr Arg
                3525                3530                3535    
Pro Ile Trp Asp Glu Ser Ile Glu Thr Leu Ile Glu Arg Ile Pro Asp
            3540                3545                3550        
Glu Asn Gly His Asp His Ala Glu Asp Pro Gln Asp Glu Gln Glu Arg
        3555                3560                3565            
Ile Glu Glu Arg Leu Ala Tyr Ile Ala Asp His Leu Gly Phe Ser Trp
    3570                3575                3580                
Thr Glu Leu Ala Arg Glu Leu Asp Phe Thr Glu Glu Gln Ile His Gln
3585                3590                3595                3600
Ile Arg Ile Glu Asn Pro Asn Ser Leu Gln Asp Gln Ser His Ala Leu
                3605                3610                3615    
Leu Lys Tyr Trp Leu Glu Arg Asp Gly Lys His Ala Thr Asp Thr Asn
            3620                3625                3630        
Leu Val Glu Cys Leu Thr Lys Ile Asn Arg Met Asp Ile Val His Leu
        3635                3640                3645            
Met Glu Thr Asn Thr Glu Pro Leu Gln Glu Arg Ile Ser His Ser Tyr
    3650                3655                3660                
Ala Glu Ile Glu Gln Thr Ile Thr Leu Asp His Ser Glu Gly Phe Ser
3665                3670                3675                3680
Val Leu Gln Glu Glu Leu Cys Thr Ala Gln His Lys Gln Lys Glu Glu
                3685                3690                3695    
Gln Ala Val Ser Lys Glu Ser Glu Thr Cys Asp His Pro Pro Ile Val
            3700                3705                3710        
Ser Glu Glu Asp Ile Ser Val Gly Tyr Ser Thr Phe Gln Asp Gly Val
        3715                3720                3725            
Pro Lys Thr Glu Gly Asp Ser Ser Ala Thr Ala Leu Phe Pro Gln Thr
    3730                3735                3740                
His Lys Glu Gln Val Gln Gln Asp Phe Ser Gly Lys Met Gln Asp Leu
3745                3750                3755                3760
Pro Glu Glu Ser Ser Leu Glu Tyr Gln Gln Glu Tyr Phe Val Thr Thr
                3765                3770                3775    
Pro Gly Thr Glu Thr Ser Glu Thr Gln Lys Ala Met Ile Val Pro Ser
            3780                3785                3790        
Ser Pro Ser Lys Thr Pro Glu Glu Val Ser Thr Pro Ala Glu Glu Glu
        3795                3800                3805            
Lys Leu Tyr Leu Gln Thr Pro Thr Ser Ser Glu Arg Gly Gly Ser Pro
    3810                3815                3820                
Ile Ile Gln Glu Pro Glu Glu Pro Ser Glu His Arg Glu Glu Ser Ser
3825                3830                3835                3840
Pro Arg Lys Thr Ser Leu Val Ile Val Glu Ser Ala Asp Asn Gln Pro
                3845                3850                3855    
Glu Thr Cys Glu Arg Leu Asp Glu Asp Ala Ala Phe Glu Lys Gly Asp
            3860                3865                3870        
Asp Met Pro Glu Ile Pro Pro Glu Thr Val Thr Glu Glu Glu Tyr Ile
        3875                3880                3885            
Asp Glu His Gly His Thr Val Val Lys Lys Val Thr Arg Lys Ile Ile
    3890                3895                3900                
Arg Arg Tyr Val Ser Ser Glu Gly Thr Glu Lys Glu Glu Ile Met Val
3905                3910                3915                3920
Gln Gly Met Pro Gln Glu Pro Val Asn Ile Glu Glu Gly Asp Gly Tyr
                3925                3930                3935    
Ser Lys Val Ile Lys Arg Val Val Leu Lys Ser Asp Thr Glu Gln Ser
            3940                3945                3950        
Glu Asp Asn Asn Glu
        3955        


<210> 6
<211> 1872
<212> PRT
<213> Homo sapiens

<400> 6
Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe
 1               5                  10                  15      
Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn
            20                  25                  30          
Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val
        35                  40                  45              
Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly
    50                  55                  60                  
Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val
65                  70                  75                  80  
Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys
                85                  90                  95      
Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val
            100                 105                 110         
Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln
        115                 120                 125             
Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp
    130                 135                 140                 
Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr
145                 150                 155                 160 
Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn
                165                 170                 175     
Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg
            180                 185                 190         
Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala
        195                 200                 205             
Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met
    210                 215                 220                 
Met Val Asn Arg Thr Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala
225                 230                 235                 240 
Ala His Tyr Gly Asn Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly
                245                 250                 255     
Ala Ala Val Asp Phe Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val
            260                 265                 270         
Ala Ser Lys Arg Gly Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg
        275                 280                 285             
Gly Gly Gln Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His
    290                 295                 300                 
Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu
305                 310                 315                 320 
Arg Gly Ala Pro Leu Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu
                325                 330                 335     
His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu
            340                 345                 350         
Gln His Lys Ala Pro Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala
        355                 360                 365             
Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Thr Lys Leu Leu
    370                 375                 380                 
Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr
385                 390                 395                 400 
Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu
                405                 410                 415     
Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu
            420                 425                 430         
Thr Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu
        435                 440                 445             
Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly
    450                 455                 460                 
Glu Thr Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val
465                 470                 475                 480 
Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu
                485                 490                 495     
Glu Gln Thr Pro Leu His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile
            500                 505                 510         
Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Thr Thr
        515                 520                 525             
Asn Gly Tyr Thr Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp
    530                 535                 540                 
Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr
545                 550                 555                 560 
Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu
                565                 570                 575     
Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala
            580                 585                 590         
Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala Ala His Tyr Asp Asn
        595                 600                 605             
Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala
    610                 615                 620                 
Thr Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn
625                 630                 635                 640 
Gln Met Gln Ile Ala Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn
                645                 650                 655     
Ile Val Thr Lys Gln Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu
            660                 665                 670         
Gly His Thr Asp Met Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile
        675                 680                 685             
His Met Ser Thr Lys Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln
    690                 695                 700                 
Glu Asp Lys Val Asn Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp
705                 710                 715                 720 
Gln Asp Ala His Thr Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys
                725                 730                 735     
His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala
            740                 745                 750         
Asn Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala
        755                 760                 765             
Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln His Gly
    770                 775                 780                 
Ala Lys Pro Asn Ala Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile
785                 790                 795                 800 
Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val
                805                 810                 815     
Thr Glu Glu Val Thr Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys
            820                 825                 830         
Leu Asn Val Pro Glu Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu
        835                 840                 845             
Glu Gly Asp Asp Thr Met Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro
    850                 855                 860                 
Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe
865                 870                 875                 880 
Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser
                885                 890                 895     
Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Thr Leu Ser His
            900                 905                 910         
Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile
        915                 920                 925             
Pro Ser His Gln Val Ser Thr Leu Ala Lys Glu Ala Glu Arg Asn Ser
    930                 935                 940                 
Tyr Arg Leu Ser Trp Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser
945                 950                 955                 960 
Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala
                965                 970                 975     
Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile
            980                 985                 990         
Ile Pro Pro Arg Lys Cys Thr Ala Pro Thr Arg Val Thr Cys Arg Leu
        995                 1000                1005            
Val Lys Arg His Arg Leu Ala Thr Met Pro Pro Met Val Glu Gly Glu
    1010                1015                1020                
Gly Leu Ala Ser Arg Leu Ile Glu Val Gly Pro Ser Gly Ala Gln Phe
1025                1030                1035                1040
Leu Gly Lys Leu His Leu Pro Thr Ala Pro Pro Pro Leu Asn Glu Gly
                1045                1050                1055    
Glu Ser Leu Val Ser Arg Ile Leu Gln Leu Gly Pro Pro Gly Thr Lys
            1060                1065                1070        
Phe Leu Gly Pro Val Ile Val Glu Ile Pro His Phe Ala Ala Leu Arg
        1075                1080                1085            
Gly Lys Glu Arg Glu Leu Val Val Leu Arg Ser Glu Asn Gly Asp Ser
    1090                1095                1100                
Trp Lys Glu His Phe Cys Asp Tyr Thr Glu Asp Glu Leu Asn Glu Ile
1105                1110                1115                1120
Leu Asn Gly Met Asp Glu Val Leu Asp Ser Pro Glu Asp Leu Glu Lys
                1125                1130                1135    
Lys Arg Ile Cys Arg Ile Ile Thr Arg Asp Phe Pro Gln Tyr Phe Ala
            1140                1145                1150        
Val Val Ser Arg Ile Lys Gln Asp Ser Asn Leu Ile Gly Pro Glu Gly
        1155                1160                1165            
Gly Val Leu Ser Ser Thr Val Val Pro Gln Val Gln Ala Val Phe Pro
    1170                1175                1180                
Glu Gly Ala Leu Thr Lys Arg Ile Arg Val Gly Leu Gln Ala Gln Pro
1185                1190                1195                1200
Met His Ser Glu Leu Val Lys Lys Ile Leu Gly Asn Lys Ala Thr Phe
                1205                1210                1215    
Ser Pro Ile Val Thr Leu Glu Pro Arg Arg Arg Lys Phe His Lys Pro
            1220                1225                1230        
Ile Thr Met Thr Ile Pro Val Pro Lys Ala Ser Ser Asp Val Met Leu
        1235                1240                1245            
Asn Gly Phe Gly Gly Asp Ala Pro Thr Leu Arg Leu Leu Cys Ser Ile
    1250                1255                1260                
Thr Gly Gly Thr Thr Pro Ala Gln Trp Glu Asp Ile Thr Gly Thr Thr
1265                1270                1275                1280
Pro Leu Thr Phe Val Asn Glu Cys Val Ser Phe Thr Thr Asn Val Ser
                1285                1290                1295    
Ala Arg Phe Trp Leu Ile Asp Cys Arg Gln Ile Gln Glu Ser Val Thr
            1300                1305                1310        
Phe Ala Ser Gln Val Tyr Arg Glu Ile Ile Cys Val Pro Tyr Met Ala
        1315                1320                1325            
Lys Phe Val Val Phe Ala Lys Ser His Asp Pro Ile Glu Ala Arg Leu
    1330                1335                1340                
Arg Cys Phe Cys Met Thr Asp Asp Lys Val Asp Lys Thr Leu Glu Gln
1345                1350                1355                1360
Gln Glu Asn Phe Ala Glu Val Ala Arg Ser Arg Asp Val Glu Val Leu
                1365                1370                1375    
Glu Gly Lys Pro Ile Tyr Val Asp Cys Phe Gly Asn Leu Val Pro Leu
            1380                1385                1390        
Thr Lys Ser Gly Gln His His Ile Phe Ser Phe Phe Ala Phe Lys Glu
        1395                1400                1405            
Asn Arg Leu Pro Leu Phe Val Lys Val Arg Asp Thr Thr Gln Glu Pro
    1410                1415                1420                
Cys Gly Arg Leu Ser Phe Met Lys Glu Pro Lys Ser Thr Arg Gly Leu
1425                1430                1435                1440
Val His Gln Ala Ile Cys Asn Leu Asn Ile Thr Leu Pro Ile Tyr Thr
                1445                1450                1455    
Lys Glu Ser Glu Ser Asp Gln Glu Gln Glu Glu Glu Ile Asp Met Thr
            1460                1465                1470        
Ser Glu Lys Asn Pro Gln Asp Glu Gln Glu Arg Ile Glu Glu Arg Leu
        1475                1480                1485            
Ala Tyr Ile Ala Asp His Leu Gly Phe Ser Trp Thr Glu Leu Ala Arg
    1490                1495                1500                
Glu Leu Asp Phe Thr Glu Glu Gln Ile His Gln Ile Arg Ile Glu Asn
1505                1510                1515                1520
Pro Asn Ser Leu Gln Asp Gln Ser His Ala Leu Leu Lys Tyr Trp Leu
                1525                1530                1535    
Glu Arg Asp Gly Lys His Ala Thr Asp Thr Asn Leu Val Glu Cys Leu
            1540                1545                1550        
Thr Lys Ile Asn Arg Met Asp Ile Val His Leu Met Glu Thr Asn Thr
        1555                1560                1565            
Glu Pro Leu Gln Glu Arg Ile Ser His Ser Tyr Ala Glu Ile Glu Gln
    1570                1575                1580                
Thr Ile Thr Leu Asp His Ser Glu Gly Phe Ser Val Leu Gln Glu Glu
1585                1590                1595                1600
Leu Cys Thr Ala Gln His Lys Gln Lys Glu Glu Gln Ala Val Ser Lys
                1605                1610                1615    
Glu Ser Glu Thr Cys Asp His Pro Pro Ile Val Ser Glu Glu Asp Ile
            1620                1625                1630        
Ser Val Gly Tyr Ser Thr Phe Gln Asp Gly Val Pro Lys Thr Glu Gly
        1635                1640                1645            
Asp Ser Ser Ala Thr Ala Leu Phe Pro Gln Thr His Lys Glu Gln Val
    1650                1655                1660                
Gln Gln Asp Phe Ser Gly Lys Met Gln Asp Leu Pro Glu Glu Ser Ser
1665                1670                1675                1680
Leu Glu Tyr Gln Gln Glu Tyr Phe Val Thr Thr Pro Gly Thr Glu Thr
                1685                1690                1695    
Ser Glu Thr Gln Lys Ala Met Ile Val Pro Ser Ser Pro Ser Lys Thr
            1700                1705                1710        
Pro Glu Glu Val Ser Thr Pro Ala Glu Glu Glu Lys Leu Tyr Leu Gln
        1715                1720                1725            
Thr Pro Thr Ser Ser Glu Arg Gly Gly Ser Pro Ile Ile Gln Glu Pro
    1730                1735                1740                
Glu Glu Pro Ser Glu His Arg Glu Glu Ser Ser Pro Arg Lys Thr Ser
1745                1750                1755                1760
Leu Val Ile Val Glu Ser Ala Asp Asn Gln Pro Glu Thr Cys Glu Arg
                1765                1770                1775    
Leu Asp Glu Asp Ala Ala Phe Glu Lys Gly Asp Asp Met Pro Glu Ile
            1780                1785                1790        
Pro Pro Glu Thr Val Thr Glu Glu Glu Tyr Ile Asp Glu His Gly His
        1795                1800                1805            
Thr Val Val Lys Lys Val Thr Arg Lys Ile Ile Arg Arg Tyr Val Ser
    1810                1815                1820                
Ser Glu Gly Thr Glu Lys Glu Glu Ile Met Val Gln Gly Met Pro Gln
1825                1830                1835                1840
Glu Pro Val Asn Ile Glu Glu Gly Asp Gly Tyr Ser Lys Val Ile Lys
                1845                1850                1855    
Arg Val Val Leu Lys Ser Asp Thr Glu Gln Ser Glu Asp Asn Asn Glu
            1860                1865                1870        


<210> 7
<211> 129
<212> PRT
<213> Homo sapiens

<400> 7
Met Ile Leu Ser Asn Thr Thr Ala Val Thr Pro Phe Leu Thr Lys Leu
 1               5                  10                  15      
Trp Gln Glu Thr Val Gln Gln Gly Gly Asn Met Ser Gly Leu Ala Arg
            20                  25                  30          
Arg Ser Pro Arg Ser Ser Asp Gly Lys Leu Glu Ala Leu Tyr Val Leu
        35                  40                  45              
Met Val Leu Gly Phe Phe Gly Phe Phe Thr Leu Gly Ile Met Leu Ser
    50                  55                  60                  
Tyr Ile Arg Ser Lys Lys Leu Glu His Ser Asn Asp Pro Phe Asn Val
65                  70                  75                  80  
Tyr Ile Glu Ser Asp Ala Trp Gln Glu Lys Asp Lys Ala Tyr Val Gln
                85                  90                  95      
Ala Arg Val Leu Glu Ser Tyr Arg Ser Cys Tyr Val Val Glu Asn His
            100                 105                 110         
Leu Ala Ile Glu Gln Pro Asn Thr His Leu Pro Glu Thr Lys Pro Ser
        115                 120                 125             
Pro
    


<210> 8
<211> 123
<212> PRT
<213> Homo sapiens

<400> 8
Met Ser Thr Leu Ser Asn Phe Thr Gln Thr Leu Glu Asp Val Phe Arg
 1               5                  10                  15      
Arg Ile Phe Ile Thr Tyr Met Asp Asn Trp Arg Gln Asn Thr Thr Ala
            20                  25                  30          
Glu Gln Glu Ala Leu Gln Ala Lys Val Asp Ala Glu Asn Phe Tyr Tyr
        35                  40                  45              
Val Ile Leu Tyr Leu Met Val Met Ile Gly Met Phe Ser Phe Ile Ile
    50                  55                  60                  
Val Ala Ile Leu Val Ser Thr Val Lys Ser Lys Arg Arg Glu His Ser
65                  70                  75                  80  
Asn Asp Pro Tyr His Gln Tyr Ile Val Glu Asp Trp Gln Glu Lys Tyr
                85                  90                  95      
Lys Ser Gln Ile Leu Asn Leu Glu Glu Ser Lys Ala Thr Ile His Glu
            100                 105                 110         
Asn Ile Gly Ala Ala Gly Phe Lys Met Ser Pro
        115                 120             


<210> 9
<211> 427
<212> PRT
<213> Homo sapiens

<400> 9
Met Gly Ser Val Arg Thr Asn Arg Tyr Ser Ile Val Ser Ser Glu Glu
 1               5                  10                  15      
Asp Gly Met Lys Leu Ala Thr Met Ala Val Ala Asn Gly Phe Gly Asn
            20                  25                  30          
Gly Lys Ser Lys Val His Thr Arg Gln Gln Cys Arg Ser Arg Phe Val
        35                  40                  45              
Lys Lys Asp Gly His Cys Asn Val Gln Phe Ile Asn Val Gly Glu Lys
    50                  55                  60                  
Gly Gln Arg Tyr Leu Ala Asp Ile Phe Thr Thr Cys Val Asp Ile Arg
65                  70                  75                  80  
Trp Arg Trp Met Leu Val Ile Phe Cys Leu Ala Phe Val Leu Ser Trp
                85                  90                  95      
Leu Phe Phe Gly Cys Val Phe Trp Leu Ile Ala Leu Leu His Gly Asp
            100                 105                 110         
Leu Asp Ala Ser Lys Glu Gly Lys Ala Cys Val Ser Glu Val Asn Ser
        115                 120                 125             
Phe Thr Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile Gly
    130                 135                 140                 
Tyr Gly Phe Arg Cys Val Thr Asp Glu Cys Pro Ile Ala Val Phe Met
145                 150                 155                 160 
Val Val Phe Gln Ser Ile Val Gly Cys Ile Ile Asp Ala Phe Ile Ile
                165                 170                 175     
Gly Ala Val Met Ala Lys Met Ala Lys Pro Lys Lys Arg Asn Glu Thr
            180                 185                 190         
Leu Val Phe Ser His Asn Ala Val Ile Ala Met Arg Asp Gly Lys Leu
        195                 200                 205             
Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Leu Val Glu
    210                 215                 220                 
Ala His Val Arg Ala Gln Leu Leu Lys Ser Arg Ile Thr Ser Glu Gly
225                 230                 235                 240 
Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Gly Phe Asp Ser
                245                 250                 255     
Gly Ile Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Val His Glu
            260                 265                 270         
Ile Asp Glu Asp Ser Pro Leu Tyr Asp Leu Ser Lys Gln Asp Ile Asp
        275                 280                 285             
Asn Ala Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu Ala
    290                 295                 300                 
Thr Ala Met Thr Thr Gln Cys Arg Ser Ser Tyr Leu Ala Asn Glu Ile
305                 310                 315                 320 
Leu Trp Gly His Arg Tyr Glu Pro Val Leu Phe Glu Glu Lys His Tyr
                325                 330                 335     
Tyr Lys Val Asp Tyr Ser Arg Phe His Lys Thr Tyr Glu Val Pro Asn
            340                 345                 350         
Thr Pro Leu Cys Ser Ala Arg Asp Leu Ala Glu Lys Lys Tyr Ile Leu
        355                 360                 365             
Ser Asn Ala Asn Ser Phe Cys Tyr Glu Asn Glu Val Ala Leu Thr Ser
    370                 375                 380                 
Lys Glu Glu Asp Asp Ser Glu Asn Gly Val Pro Glu Ser Thr Ser Thr
385                 390                 395                 400 
Asp Thr Pro Pro Asp Ile Asp Leu His Asn Gln Ala Ser Val Pro Leu
                405                 410                 415     
Glu Pro Arg Pro Leu Arg Arg Glu Ser Glu Ile
            420                 425         

