                         SEQUENCE LISTING

<110>  GeneSys Ltd
       Clark, Duncan R
       Morant, Nicholas
 
<120>  Enzyme

<130>  P1443PC00

<150>  GB0804722.7
<151>  2008-03-14

<150>  US 61/069397
<151>  2008-03-14

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  775
<212>  PRT
<213>  Palaeococcus ferrophilus

<400>  1

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Val 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Arg 
    50                  55                  60                  


Ile Thr Lys Ala Glu Lys Val Glu Arg Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Ser His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Ala Val Ser Thr Glu Lys Asp Met Ile Lys 
            180                 185                 190         


Ala Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Asp Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Arg Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Asn Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Gly Arg Glu Tyr Asp Glu Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Tyr Lys Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Arg Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Ser Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Glu Asp Ala Glu Thr Ile Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Lys Tyr Ile Asn Ser Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Arg Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asn Val Glu Glu Ala Val 
625                 630                 635                 640 


Ser Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Lys Lys 
    770                 775 


<210>  2
<211>  1305
<212>  PRT
<213>  Palaeococcus ferrophilus

<400>  2

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Val 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Arg 
    50                  55                  60                  


Ile Thr Lys Ala Glu Lys Val Glu Arg Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Ser His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Ala Val Ser Thr Glu Lys Asp Met Ile Lys 
            180                 185                 190         


Ala Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Asp Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Arg Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Asn Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Gly Arg Glu Tyr Asp Glu Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Tyr Lys Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Arg Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Ile Leu Pro Asp 
                485                 490                 495     


Glu Trp Leu Pro Ile Ile Glu Asn Gly Thr Val Arg Phe Val Arg Ile 
            500                 505                 510         


Gly Glu Phe Ile Asp Trp Lys Met Asp Glu Asn Ala Glu Arg Val His 
        515                 520                 525             


Arg Glu Gly Glu Thr Glu Ile Leu Glu Val Ser Gly Leu Glu Val Gln 
    530                 535                 540                 


Ser Phe Asn Arg Glu Thr Lys Lys Ala Glu Leu Lys Arg Val Lys Ala 
545                 550                 555                 560 


Leu Ile Arg His Arg Tyr Ser Gly Lys Ala Tyr Asn Ile Lys Leu Lys 
                565                 570                 575     


Ser Gly Arg Arg Ile Lys Ile Thr Ser Gly His Ser Leu Phe Val Glu 
            580                 585                 590         


Val Thr Gly Asp Glu Leu Lys Pro Gly Asp Leu Val Ala Val Pro Arg 
        595                 600                 605             


Arg Val Lys Leu Pro Glu Arg Asn His Val Leu Asn Leu Val Glu Leu 
    610                 615                 620                 


Leu Leu Gly Phe Pro Glu Asp Glu Thr Ser Asp Ile Val Met Thr Ile 
625                 630                 635                 640 


Pro Val Lys Glu Arg Lys Asn Phe Phe Lys Gly Met Leu Arg Thr Leu 
                645                 650                 655     


Arg Trp Ile Phe Gly Glu Glu Lys Arg Pro Arg Thr Ala Arg Arg Tyr 
            660                 665                 670         


Leu Lys His Leu Glu Asp Leu Gly Tyr Val Arg Leu Lys Lys Ile Gly 
        675                 680                 685             


Tyr Glu Val Leu Asp Trp Glu Ala Leu Arg Lys Tyr Arg Arg Leu Tyr 
    690                 695                 700                 


Glu Ala Leu Val Glu Lys Ile Arg Tyr Asn Gly Asn Lys Arg Glu Tyr 
705                 710                 715                 720 


Leu Val Glu Phe Asn Ser Ile Arg Asp Val Val Ser Leu Ile Pro Pro 
                725                 730                 735     


Glu Glu Leu Lys Glu Trp Arg Ile Gly Thr Leu Asn Gly Phe Arg Met 
            740                 745                 750         


Ser Pro Phe Val Glu Val Asp Glu Ser Phe Ala Lys Leu Leu Gly Tyr 
        755                 760                 765             


Tyr Val Ser Glu Gly Tyr Ala Arg Lys Gln Arg Asn Pro Lys Asn Gly 
    770                 775                 780                 


Trp Ser Tyr Ser Val Lys Leu Tyr Asn Glu Asp Pro Glu Val Leu Asn 
785                 790                 795                 800 


Asp Met Gly Lys Leu Ala Glu Arg Phe Phe Gly Lys Val Arg Lys Gly 
                805                 810                 815     


Arg Asn Tyr Val Glu Ile Ser Arg Lys Met Gly Tyr Leu Leu Phe Glu 
            820                 825                 830         


Ser Leu Cys Gly Val Leu Ala Lys Asn Lys Met Val Pro Glu Phe Ile 
        835                 840                 845             


Phe Thr Phe Pro Thr Gly Val Arg Met Ala Phe Leu Glu Gly Tyr Phe 
    850                 855                 860                 


Ile Gly Asp Gly Asp Val His Pro Ser Lys Arg Leu Arg Leu Ser Thr 
865                 870                 875                 880 


Lys Ser Glu Leu Leu Ala Asn Gln Leu Val Leu Leu Leu Asn Ser Val 
                885                 890                 895     


Gly Val Ser Ala Val Lys Leu Gly His Asp Ser Ser Val Tyr Arg Val 
            900                 905                 910         


Tyr Ile Asn Glu Ala Leu Pro Phe Val Lys Leu Asp Lys Lys Lys Asn 
        915                 920                 925             


Ala Tyr Tyr Ser His Val Ile Pro Lys Glu Val Leu Ser Glu Ile Phe 
    930                 935                 940                 


Glu Lys Val Phe Gln Lys Asn Val Ser Pro Gln Thr Phe Arg Lys Met 
945                 950                 955                 960 


Val Glu Gly Gly Lys Leu Asp Tyr Glu Lys Ala Gln Lys Leu Ser Trp 
                965                 970                 975     


Leu Ile Asn Gly Asp Leu Val Leu Asp Arg Val Glu Ser Val Glu Ala 
            980                 985                 990         


Glu Glu Tyr Ser Gly Tyr Val Tyr  Asp Leu Ser Val Glu  Asp Asn Glu 
        995                 1000                 1005             


Asn Phe  Leu Val Gly Phe Gly  Leu Val Tyr Ala His  Asn Ser Tyr 
    1010                 1015                 1020             


Tyr Gly  Tyr Tyr Gly Tyr Ala  Arg Ala Arg Trp Tyr  Cys Lys Glu 
    1025                 1030                 1035             


Cys Ala  Glu Ser Val Thr Ala  Trp Gly Arg Glu Tyr  Ile Glu Met 
    1040                 1045                 1050             


Ser Ile  Arg Glu Ile Glu Glu  Lys Tyr Gly Phe Lys  Val Leu Tyr 
    1055                 1060                 1065             


Ala Asp  Thr Asp Gly Phe His  Ala Thr Ile Pro Gly  Glu Asp Ala 
    1070                 1075                 1080             


Glu Thr  Ile Lys Lys Lys Ala  Met Glu Phe Leu Lys  Tyr Ile Asn 
    1085                 1090                 1095             


Ser Lys  Leu Pro Gly Ala Leu  Glu Leu Glu Tyr Glu  Gly Phe Tyr 
    1100                 1105                 1110             


Arg Arg  Gly Phe Phe Val Thr  Lys Lys Lys Tyr Ala  Val Ile Asp 
    1115                 1120                 1125             


Glu Glu  Gly Lys Ile Thr Thr  Arg Gly Leu Glu Ile  Val Arg Arg 
    1130                 1135                 1140             


Asp Trp  Ser Glu Ile Ala Lys  Glu Thr Gln Ala Arg  Val Leu Glu 
    1145                 1150                 1155             


Ala Leu  Leu Lys Asp Gly Asn  Val Glu Glu Ala Val  Ser Ile Val 
    1160                 1165                 1170             


Lys Glu  Val Thr Glu Lys Leu  Ser Lys Tyr Glu Val  Pro Pro Glu 
    1175                 1180                 1185             


Lys Leu  Val Ile His Glu Gln  Ile Thr Arg Glu Leu  Lys Asp Tyr 
    1190                 1195                 1200             


Lys Ala  Thr Gly Pro His Val  Ala Ile Ala Lys Arg  Leu Ala Ala 
    1205                 1210                 1215             


Arg Gly  Val Lys Ile Arg Pro  Gly Thr Val Ile Ser  Tyr Ile Val 
    1220                 1225                 1230             


Leu Lys  Gly Ser Gly Arg Ile  Gly Asp Arg Ala Ile  Pro Phe Asp 
    1235                 1240                 1245             


Glu Phe  Asp Pro Ala Lys His  Arg Tyr Asp Ala Glu  Tyr Tyr Ile 
    1250                 1255                 1260             


Glu Asn  Gln Val Leu Pro Ala  Val Glu Arg Ile Leu  Lys Ala Phe 
    1265                 1270                 1275             


Gly Tyr  Arg Lys Glu Asp Leu  Arg Tyr Gln Lys Thr  Arg Gln Val 
    1280                 1285                 1290             


Gly Leu  Gly Ala Trp Leu Lys  Pro Lys Gly Lys Lys  
    1295                 1300                 1305 


<210>  3
<211>  2328
<212>  DNA
<213>  Palaeococcus ferrophilus

<400>  3
atgatcctcg atgctgacta cataaccgag aatggaaagc ccgtcgtgag gatattcaag       60

aaggagaacg gcgagttcaa ggttgagtac gatagaaact ttgagcccta catctacgcc      120

ctcctgaagg acgactccgc gattgaagaa atcaagaaga taaccgccga gaggcacgga      180

acggtggtga gaattacaaa ggccgagaag gtggagagga agtttctcgg caggccggtt      240

gaagtgtgga agctctactt cacccatcca caggacgtcc cggccataag ggataagata      300

aggagccatc cggcagttgt ggacatctac gagtacgaca tacccttcgc gaagagatac      360

ctcatcgaca agggcctggt tccgatggag ggggacgagg agctgaaaat gctcgccttc      420

gacatcgaga cgctctatca cgagggcgag gagttcgccg agggacccat tctgatgata      480

agctacgctg acgaaagtga ggctcgcgtc atcacctgga agaaggttga cctcccctac      540

gtggatgccg tctcaaccga aaaagacatg ataaaggcct ttttgagggt cgtgaaggag      600

aaggacccgg acgttctcat aacttacaac ggcgacaact tcgacttcgc ctatctaaaa      660

aagcgctgcg aaaagctcgg ggtgaagttc atccttggaa gggatgggag cgagccgaag      720

atccagagga tgggcgacag atttgcggtc gatgtgaagg gaaggataca cttcgatctc      780

tatcccgtga taagaaggac gataaacctg ccgacctaca cgcttgaggc cgtctatgag      840

gcgatatttg gaaggccgaa ggagaaggtc tacgcggagg agatagctca agcctgggaa      900

accaacgagg gacttgagag ggtcgctcgc tactcaatgg aggatgccaa agtcacctac      960

gagctgggaa aggagttctt cccgatggag gcccagcttt cccgtttgat cggccagccc     1020

ctctgggacg tctcgcgctc cagcacgggc aatctggtcg agtggttcct ccttcggaag     1080

gcctacgaga ggaacgaact ggccccaaac aagccctccg gaagggagta cgacgagagg     1140

cgcggcggat acgctggcgg ctacgtgaag gagccggaga agggcctttg ggagaacata     1200

gtgtatctag attacaaatc gttatatccc tcgataataa tcacccacaa cgtctcgccg     1260

gatacgctca acagagaggg atgcaaggag tacgatgtgg ctcctcaggt cggccaccgc     1320

ttctgcaagg acttcccggg cttcattcct agcctcctcg gagatcttct ggaggagagg     1380

cagaagataa agaggaagat gaaggccact attgacccga tcgagaggag gctcctcgat     1440

tacaggcagc gggcaatcaa gatcctggcg aacagttatt acggctacta cggctacgca     1500

agggcccgct ggtactgcaa ggagtgcgcc gagagcgtca ccgcctgggg aagggagtac     1560

atcgaaatga gcatacggga gatagaagag aaatacggct ttaaagtcct ctacgcggac     1620

acggacggtt tccacgcgac gataccagga gaagatgccg agaccatcaa aaagaaggcc     1680

atggagttcc tcaaatatat caactccaaa ctcccaggtg cgcttgagct cgagtacgag     1740

ggcttctaca ggcgcggttt cttcgtcacc aagaagaagt acgcggtgat agacgaggag     1800

ggcaagataa cgacgcgcgg gcttgagata gtcaggcgtg actggagcga gatagccaag     1860

gagactcagg cgagggttct tgaggccctt ctcaaggacg gtaacgttga ggaggccgta     1920

agcatagtca aagaagtgac ggagaagctg agcaagtacg aggttccgcc ggagaagctc     1980

gttatccacg agcagataac gcgcgagctg aaggactaca aggcaacggg cccgcacgtg     2040

gcgatagcga agaggttagc cgcgaggggc gtcaaaatcc gccccgggac ggtcatcagc     2100

tacatagtcc tcaagggctc tggaaggata ggcgacaggg cgattccctt cgacgagttc     2160

gacccggcca agcaccgcta cgacgctgaa tactacatcg agaaccaggt tctgccggcc     2220

gttgagagga ttctaaaggc cttcggctat agaaaggagg atctgcgcta ccagaagacg     2280

aggcaggttg ggcttggagc gtggttaaag ccgaagggga agaagtga                  2328


<210>  4
<211>  3918
<212>  DNA
<213>  Palaeococcus ferrophilus

<400>  4
atgatcctcg atgctgacta cataaccgag aatggaaagc ccgtcgtgag gatattcaag       60

aaggagaacg gcgagttcaa ggttgagtac gatagaaact ttgagcccta catctacgcc      120

ctcctgaagg acgactccgc gattgaagaa atcaagaaga taaccgccga gaggcacgga      180

acggtggtga gaattacaaa ggccgagaag gtggagagga agtttctcgg caggccggtt      240

gaagtgtgga agctctactt cacccatcca caggacgtcc cggccataag ggataagata      300

aggagccatc cggcagttgt ggacatctac gagtacgaca tacccttcgc gaagagatac      360

ctcatcgaca agggcctggt tccgatggag ggggacgagg agctgaaaat gctcgccttc      420

gacatcgaga cgctctatca cgagggcgag gagttcgccg agggacccat tctgatgata      480

agctacgctg acgaaagtga ggctcgcgtc atcacctgga agaaggttga cctcccctac      540

gtggatgccg tctcaaccga aaaagacatg ataaaggcct ttttgagggt cgtgaaggag      600

aaggacccgg acgttctcat aacttacaac ggcgacaact tcgacttcgc ctatctaaaa      660

aagcgctgcg aaaagctcgg ggtgaagttc atccttggaa gggatgggag cgagccgaag      720

atccagagga tgggcgacag atttgcggtc gatgtgaagg gaaggataca cttcgatctc      780

tatcccgtga taagaaggac gataaacctg ccgacctaca cgcttgaggc cgtctatgag      840

gcgatatttg gaaggccgaa ggagaaggtc tacgcggagg agatagctca agcctgggaa      900

accaacgagg gacttgagag ggtcgctcgc tactcaatgg aggatgccaa agtcacctac      960

gagctgggaa aggagttctt cccgatggag gcccagcttt cccgtttgat cggccagccc     1020

ctctgggacg tctcgcgctc cagcacgggc aatctggtcg agtggttcct ccttcggaag     1080

gcctacgaga ggaacgaact ggccccaaac aagccctccg gaagggagta cgacgagagg     1140

cgcggcggat acgctggcgg ctacgtgaag gagccggaga agggcctttg ggagaacata     1200

gtgtatctag attacaaatc gttatatccc tcgataataa tcacccacaa cgtctcgccg     1260

gatacgctca acagagaggg atgcaaggag tacgatgtgg ctcctcaggt cggccaccgc     1320

ttctgcaagg acttcccggg cttcattcct agcctcctcg gagatcttct ggaggagagg     1380

cagaagataa agaggaagat gaaggccact attgacccga tcgagaggag gctcctcgat     1440

tacaggcagc gggcaatcaa gatcctggcg aacagtattc ttcccgacga gtggcttccc     1500

attattgaaa acgggacggt tcgcttcgtc aggattgggg agttcataga ctggaaaatg     1560

gatgaaaacg ctgaaagagt gcatagggaa ggggaaacgg aaatccttga agtcagtggt     1620

cttgaagtcc aatccttcaa cagggaaacg aagaaggccg agcttaagag ggtaaaggcc     1680

ctaatcaggc accgctattc gggcaaagct tacaacataa aactgaagtc tgggaggaga     1740

ataaagataa cctctggcca cagcctcttc gttgaggtca cgggggatga actcaagccc     1800

ggcgacctgg ttgcagtccc gcggagggtg aagcttccgg agagaaacca cgtgttgaac     1860

ctcgtggagc ttctcctcgg attccctgag gacgaaacgt cagacattgt tatgacaatt     1920

cccgtcaaag agcggaagaa cttctttaaa ggaatgctta gaaccctgcg ctggattttt     1980

ggggaggaga aaaggccaag gacagcaagg cgttatctca agcaccttga ggatctgggt     2040

tatgtcaggc ttaagaagat aggctatgaa gtacttgact gggaggcact taggaaatac     2100

agaaggctct acgaggcact tgtcgaaaaa atcagataca acggcaacaa gagagagtac     2160

ctcgttgagt tcaactccat ccgggacgtg gtaagcctaa ttcccccgga agagcttaag     2220

gagtggagaa ttggaacgct gaacggcttt agaatgagtc cttttgtgga ggttgacgag     2280

tccttcgcaa agctcctcgg ctactatgtg agcgagggct atgcaagaaa gcagagaaat     2340

cccaaaaacg gctggagcta cagcgtgaag ctctacaacg aagaccctga agtactgaac     2400

gatatgggga agctcgctga gaggttcttt ggaaaggtta gaaaaggccg gaactacgtt     2460

gaaatatcga ggaagatggg ctacctgctc tttgagagcc tttgcggtgt tctggcgaaa     2520

aacaagatgg ttccagagtt catcttcacg tttccgacag gggttaggat ggctttcctt     2580

gaggggtact tcatcggcga tggcgacgtc cacccgagca aaaggctcag gctctccacg     2640

aagagcgagc ttttggccaa ccagctcgtc ctcctcttga actctgtggg agtttcggcc     2700

gtaaagctcg ggcacgacag cagcgtttac agggtttaca taaacgaggc gctcccgttc     2760

gtaaagctgg acaagaaaaa gaacgcctac tattcgcacg tgatccccaa ggaagtcctg     2820

agcgagatct ttgagaaggt cttccagaag aacgtcagtc ctcagacctt caggaagatg     2880

gttgaaggcg gaaagctcga ttatgaaaag gcccaaaaac tctcctggct cattaatggc     2940

gatctagtgc ttgaccgtgt tgagtccgtt gaggctgagg aatacagcgg ctatgtctac     3000

gacctgagcg tcgaagacaa cgagaacttc ctcgttggtt ttgggttggt ctatgctcac     3060

aacagttatt acggctacta cggctacgca agggcccgct ggtactgcaa ggagtgcgcc     3120

gagagcgtca ccgcctgggg aagggagtac atcgaaatga gcatacggga gatagaagag     3180

aaatacggct ttaaagtcct ctacgcggac acggacggtt tccacgcgac gataccagga     3240

gaagatgccg agaccatcaa aaagaaggcc atggagttcc tcaaatatat caactccaaa     3300

ctcccaggtg cgcttgagct cgagtacgag ggcttctaca ggcgcggttt cttcgtcacc     3360

aagaagaagt acgcggtgat agacgaggag ggcaagataa cgacgcgcgg gcttgagata     3420

gtcaggcgtg actggagcga gatagccaag gagactcagg cgagggttct tgaggccctt     3480

ctcaaggacg gtaacgttga ggaggccgta agcatagtca aagaagtgac ggagaagctg     3540

agcaagtacg aggttccgcc ggagaagctc gttatccacg agcagataac gcgcgagctg     3600

aaggactaca aggcaacggg cccgcacgtg gcgatagcga agaggttagc cgcgaggggc     3660

gtcaaaatcc gccccgggac ggtcatcagc tacatagtcc tcaagggctc tggaaggata     3720

ggcgacaggg cgattccctt cgacgagttc gacccggcca agcaccgcta cgacgctgaa     3780

tactacatcg agaaccaggt tctgccggcc gttgagagga ttctaaaggc cttcggctat     3840

agaaaggagg atctgcgcta ccagaagacg aggcaggttg ggcttggagc gtggttaaag     3900

ccgaagggga agaagtga                                                   3918


<210>  5
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a, c, g, or t

<400>  5
cgcgggagaa cctggttntc datrtarta                                         29


<210>  6
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  Protein fragment

<400>  6

Tyr Tyr Ile Glu Asn Gln Val Leu Pro 
1               5                   


<210>  7
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is a, c, g, or t

<400>  7
tactacggat aggccaargc nagrtggta                                         29


<210>  8
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  Protein fragment


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is STOP

<400>  8

Tyr Tyr Gly Xaa Ala Asn Ala Arg Trp 
1               5                   


<210>  9
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  9
tgtaaaacga cggccagt                                                     18


<210>  10
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  10
agcggataac aatttcacac agga                                              24


<210>  11
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  11
tatctcgctc cagtcacgcc                                                   20


<210>  12
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<400>  12
agggagttct tcccnatgga rgc                                               23


<210>  13
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Protein fragment

<400>  13

Lys Glu Phe Phe Pro Met Glu Ala 
1               5               


<210>  14
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  14
aacaccgcaa aggctctca                                                    19


<210>  15
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  15
gcttgagttc atcccccgt                                                    19


<210>  16
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  16
tcaggcgagg gttcttgagg                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  17
cgtggcgata gcgaagaggt                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  18
tatctcgctc cagtcacgcc                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  19
cgctggcggc tacgtgaagg                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  20
tctcgtcgta ctcccttccg                                                   20


<210>  21
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  21
gtttggggcc agttcgtt                                                     18


<210>  22
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  22
aaagtgaggc tcgcgtcatc                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  23
actcctcgcc ctcgtgatag                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  24
attttcagct cctcgtcccc                                                   20


<210>  25
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  25
aagcttcata tgatcctgga tgctgactac ataaccgaga atgg                        44


<210>  26
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  26
gaattcgtcg acttacttct tccccttcgg ctttaacca                              39


<210>  27
<211>  55
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  27
ttcccctcta gaaataattt tgtttaactt taagaaggag atatactatg cacca            55


<210>  28
<211>  55
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  28
gaattcggat ccgctagcca tatggtgatg gtgatggtgc atagtatatc tcctt            55


<210>  29
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  29
aaattaatac gactcactat aggg                                              24


<210>  30
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  30
gctagttatt gctcagcgg                                                    19


<210>  31
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  31
aagtttgaat tcgccaggat cttgattgcc cgctgc                                 36


<210>  32
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  32
cctggcgaat tcttattacg gctactacgg ctacgcaag                              39


<210>  33
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  33
cctgctctgc cgcttcacgc                                                   20


<210>  34
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  34
ccatgattca gtgtgcccgt ctgg                                              24


<210>  35
<211>  20
<212>  PRT
<213>  Palaeococcus ferrophilus

<400>  35

Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr Tyr 
1               5                   10                  15      


Gly Tyr Ala Arg 
            20  


<210>  36
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Met or Ala

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Arg or Ala

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Lys, Arg or His

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Val, Ile or Lys

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Val or Ile

<400>  36

Glu Xaa Xaa Xaa Ile Lys Xaa Phe Leu Xaa Xaa Xaa Xaa Glu Lys Asp 
1               5                   10                  15      


Pro Asp Xaa Xaa Xaa Thr Tyr 
            20              


<210>  37
<211>  36
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Tyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Arg, Lys or Thr

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Phe or Leu

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Tyr or Ser

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Tyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Ser or Ala

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Val or Ile

<400>  37

Gly Xaa Val Lys Glu Pro Glu Xaa Gly Leu Trp Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Leu Asp Xaa Xaa Xaa Leu Tyr Pro Ser Ile Ile Xaa Thr His Asn Val 
            20                  25                  30          


Ser Pro Asp Thr 
        35      


<210>  38
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Gly, Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asn, Asp, His or Glu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Glu or Thr

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Tyr, Phe or His

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Arg, Lys or Thr

<400>  38

Gly Phe Ile Pro Ser Xaa Leu Xaa Xaa Leu Xaa Xaa Xaa Arg Gln Xaa 
1               5                   10                  15      


Xaa Lys Xaa Lys Met Lys 
            20          


<210>  39
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Tyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Tyr or Thr

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Ala or Pro

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Lys or Arg

<400>  39

Asp Tyr Arg Gln Xaa Ala Xaa Lys Xaa Leu Ala Asn Ser Xaa Tyr Gly 
1               5                   10                  15      


Tyr Xaa Gly Tyr Xaa Xaa 
            20          


<210>  40
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe or Leu

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Tyr, Phe or His

<400>  40

Asp Thr Asp Gly Xaa Xaa Ala 
1               5           


<210>  41
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Gly or His

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Val, Thr or Ile

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glu or Asp

<400>  41

Asp Glu Glu Gly Xaa Xaa Xaa Thr Arg Gly Leu Glu Xaa Val Arg Arg 
1               5                   10                  15      


Asp Trp Ser Xaa Ile Ala Lys 
            20              


<210>  42
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid fragment

<400>  42
tctagaaata attttgttta actttaagaa ggagatatac tatgcaccat caccatcacc       60

atatggcta                                                               69


<210>  43
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Protein tag sequence

<400>  43

Met His His His His His His Met 
1               5               


<210>  44
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Val or Ile

<400>  44

Leu Tyr Pro Ser Ile Ile Xaa Thr His Asn Val Ser Pro Asp Thr 
1               5                   10                  15  


<210>  45
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Glu or Asp

<400>  45

Thr Arg Gly Leu Glu Xaa Val Arg Arg Asp Trp Ser Xaa Ile Ala Lys 
1               5                   10                  15      


<210>  46
<211>  842
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric protein

<400>  46

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Val 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Arg 
    50                  55                  60                  


Ile Thr Lys Ala Glu Lys Val Glu Arg Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Ser His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Ala Val Ser Thr Glu Lys Asp Met Ile Lys 
            180                 185                 190         


Ala Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Asp Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Arg Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Asn Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Gly Arg Glu Tyr Asp Glu Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Tyr Lys Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Arg Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Ser Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Glu Asp Ala Glu Thr Ile Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Lys Tyr Ile Asn Ser Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Arg Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asn Val Glu Glu Ala Val 
625                 630                 635                 640 


Ser Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Lys Lys Gly Ser Gly Thr His Met Ala Cys Glu 
    770                 775                 780                 


Lys Pro Val Lys Val Arg Asp Pro Thr Thr Gly Lys Glu Val Glu Leu 
785                 790                 795                 800 


Val Pro Ile Lys Val Trp Gln Leu Ala Pro Arg Gly Arg Lys Gly Val 
                805                 810                 815     


Lys Ile Gly Leu Phe Lys Ser Pro Glu Thr Gly Lys Tyr Phe Arg Ala 
            820                 825                 830         


Lys Val Pro Asp Asp Tyr Pro Ile Cys Ser 
        835                 840         


<210>  47
<211>  2529
<212>  DNA
<213>  Artificial

<220>
<223>  Cloned construct

<400>  47
atgatcctcg atgctgacta cataaccgag aatggaaagc ccgtcgtgag gatattcaag       60

aaggagaacg gcgagttcaa ggttgagtac gatagaaact ttgagcccta catctacgcc      120

ctcctgaagg acgactccgc gattgaagaa atcaagaaga taaccgccga gaggcacgga      180

acggtggtga gaattacaaa ggccgagaag gtggagagga agtttctcgg caggccggtt      240

gaagtgtgga agctctactt cacccatcca caggacgtcc cggccataag ggataagata      300

aggagccatc cggcagttgt ggacatctac gagtacgaca tacccttcgc gaagagatac      360

ctcatcgaca agggcctggt tccgatggag ggggacgagg agctgaaaat gctcgccttc      420

gacatcgaga cgctctatca cgagggcgag gagttcgccg agggacccat tctgatgata      480

agctacgctg acgaaagtga ggctcgcgtc atcacctgga agaaggttga cctcccctac      540

gtggatgccg tctcaaccga aaaagacatg ataaaggcct ttttgagggt cgtgaaggag      600

aaggacccgg acgttctcat aacttacaac ggcgacaact tcgacttcgc ctatctaaaa      660

aagcgctgcg aaaagctcgg ggtgaagttc atccttggaa gggatgggag cgagccgaag      720

atccagagga tgggcgacag atttgcggtc gatgtgaagg gaaggataca cttcgatctc      780

tatcccgtga taagaaggac gataaacctg ccgacctaca cgcttgaggc cgtctatgag      840

gcgatatttg gaaggccgaa ggagaaggtc tacgcggagg agatagctca agcctgggaa      900

accaacgagg gacttgagag ggtcgctcgc tactcaatgg aggatgccaa agtcacctac      960

gagctgggaa aggagttctt cccgatggag gcccagcttt cccgtttgat cggccagccc     1020

ctctgggacg tctcgcgctc cagcacgggc aatctggtcg agtggttcct ccttcggaag     1080

gcctacgaga ggaacgaact ggccccaaac aagccctccg gaagggagta cgacgagagg     1140

cgcggcggat acgctggcgg ctacgtgaag gagccggaga agggcctttg ggagaacata     1200

gtgtatctag attacaaatc gttatatccc tcgataataa tcacccacaa cgtctcgccg     1260

gatacgctca acagagaggg atgcaaggag tacgatgtgg ctcctcaggt cggccaccgc     1320

ttctgcaagg acttcccggg cttcattcct agcctcctcg gagatcttct ggaggagagg     1380

cagaagataa agaggaagat gaaggccact attgacccga tcgagaggag gctcctcgat     1440

tacaggcagc gggcaatcaa gatcctggcg aacagttatt acggctacta cggctacgca     1500

agggcccgct ggtactgcaa ggagtgcgcc gagagcgtca ccgcctgggg aagggagtac     1560

atcgaaatga gcatacggga gatagaagag aaatacggct ttaaagtcct ctacgcggac     1620

acggacggtt tccacgcgac gataccagga gaagatgccg agaccatcaa aaagaaggcc     1680

atggagttcc tcaaatatat caactccaaa ctcccaggtg cgcttgagct cgagtacgag     1740

ggcttctaca ggcgcggttt cttcgtcacc aagaagaagt acgcggtgat agacgaggag     1800

ggcaagataa cgacgcgcgg gcttgagata gtcaggcgtg actggagcga gatagccaag     1860

gagactcagg cgagggttct tgaggccctt ctcaaggacg gtaacgttga ggaggccgta     1920

agcatagtca aagaagtgac ggagaagctg agcaagtacg aggttccgcc ggagaagctc     1980

gttatccacg agcagataac gcgcgagctg aaggactaca aggcaacggg cccgcacgtg     2040

gcgatagcga agaggttagc cgcgaggggc gtcaaaatcc gccccgggac ggtcatcagc     2100

tacatagtcc tcaagggctc tggaaggata ggcgacaggg cgattccctt cgacgagttc     2160

gacccggcca agcaccgcta cgacgctgaa tactacatcg agaaccaggt tctgccggcc     2220

gttgagagga ttctaaaggc cttcggctat agaaaggagg atctgcgcta ccagaagacg     2280

aggcaggttg ggcttggagc gtggttaaag ccgaagggga agaagggatc cggaacacac     2340

atggcgtgtg agaagcctgt taaggttcgt gaccctacta ctggtaagga ggtagagctg     2400

gtaccaatca aggtgtggca gctagcaccc aggggtagga agggcgtcaa gataggccta     2460

ttcaagagcc ccgaaacagg caagtacttc agagccaagg taccagacga ctacccaatc     2520

tgcagctaa                                                             2529


<210>  48
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  48
gaattcgtcg acttaggatc ccttcttccc cttcggcttt aacca                       45


<210>  49
<211>  2334
<212>  DNA
<213>  Artificial

<220>
<223>  Cloned construct

<400>  49
atgatcctcg atgctgacta cataaccgag aatggaaagc ccgtcgtgag gatattcaag       60

aaggagaacg gcgagttcaa ggttgagtac gatagaaact ttgagcccta catctacgcc      120

ctcctgaagg acgactccgc gattgaagaa atcaagaaga taaccgccga gaggcacgga      180

acggtggtga gaattacaaa ggccgagaag gtggagagga agtttctcgg caggccggtt      240

gaagtgtgga agctctactt cacccatcca caggacgtcc cggccataag ggataagata      300

aggagccatc cggcagttgt ggacatctac gagtacgaca tacccttcgc gaagagatac      360

ctcatcgaca agggcctggt tccgatggag ggggacgagg agctgaaaat gctcgccttc      420

gacatcgaga cgctctatca cgagggcgag gagttcgccg agggacccat tctgatgata      480

agctacgctg acgaaagtga ggctcgcgtc atcacctgga agaaggttga cctcccctac      540

gtggatgccg tctcaaccga aaaagacatg ataaaggcct ttttgagggt cgtgaaggag      600

aaggacccgg acgttctcat aacttacaac ggcgacaact tcgacttcgc ctatctaaaa      660

aagcgctgcg aaaagctcgg ggtgaagttc atccttggaa gggatgggag cgagccgaag      720

atccagagga tgggcgacag atttgcggtc gatgtgaagg gaaggataca cttcgatctc      780

tatcccgtga taagaaggac gataaacctg ccgacctaca cgcttgaggc cgtctatgag      840

gcgatatttg gaaggccgaa ggagaaggtc tacgcggagg agatagctca agcctgggaa      900

accaacgagg gacttgagag ggtcgctcgc tactcaatgg aggatgccaa agtcacctac      960

gagctgggaa aggagttctt cccgatggag gcccagcttt cccgtttgat cggccagccc     1020

ctctgggacg tctcgcgctc cagcacgggc aatctggtcg agtggttcct ccttcggaag     1080

gcctacgaga ggaacgaact ggccccaaac aagccctccg gaagggagta cgacgagagg     1140

cgcggcggat acgctggcgg ctacgtgaag gagccggaga agggcctttg ggagaacata     1200

gtgtatctag attacaaatc gttatatccc tcgataataa tcacccacaa cgtctcgccg     1260

gatacgctca acagagaggg atgcaaggag tacgatgtgg ctcctcaggt cggccaccgc     1320

ttctgcaagg acttcccggg cttcattcct agcctcctcg gagatcttct ggaggagagg     1380

cagaagataa agaggaagat gaaggccact attgacccga tcgagaggag gctcctcgat     1440

tacaggcagc gggcaatcaa gatcctggcg aacagttatt acggctacta cggctacgca     1500

agggcccgct ggtactgcaa ggagtgcgcc gagagcgtca ccgcctgggg aagggagtac     1560

atcgaaatga gcatacggga gatagaagag aaatacggct ttaaagtcct ctacgcggac     1620

acggacggtt tccacgcgac gataccagga gaagatgccg agaccatcaa aaagaaggcc     1680

atggagttcc tcaaatatat caactccaaa ctcccaggtg cgcttgagct cgagtacgag     1740

ggcttctaca ggcgcggttt cttcgtcacc aagaagaagt acgcggtgat agacgaggag     1800

ggcaagataa cgacgcgcgg gcttgagata gtcaggcgtg actggagcga gatagccaag     1860

gagactcagg cgagggttct tgaggccctt ctcaaggacg gtaacgttga ggaggccgta     1920

agcatagtca aagaagtgac ggagaagctg agcaagtacg aggttccgcc ggagaagctc     1980

gttatccacg agcagataac gcgcgagctg aaggactaca aggcaacggg cccgcacgtg     2040

gcgatagcga agaggttagc cgcgaggggc gtcaaaatcc gccccgggac ggtcatcagc     2100

tacatagtcc tcaagggctc tggaaggata ggcgacaggg cgattccctt cgacgagttc     2160

gacccggcca agcaccgcta cgacgctgaa tactacatcg agaaccaggt tctgccggcc     2220

gttgagagga ttctaaaggc cttcggctat agaaaggagg atctgcgcta ccagaagacg     2280

aggcaggttg ggcttggagc gtggttaaag ccgaagggga agaagggatc ctaa           2334


<210>  50
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  50
gaattcggat ccggaacaca catggcgtgt gagaagcctg                             40


<210>  51
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  51
gaattcgtcg acttagctgc agattgggta                                        30


<210>  52
<211>  210
<212>  DNA
<213>  Artificial

<220>
<223>  Cloned construct

<400>  52
ggatccggaa cacacatggc gtgtgagaag cctgttaagg ttcgtgaccc tactactggt       60

aaggaggtag agctggtacc aatcaaggtg tggcagctag cacccagggg taggaagggc      120

gtcaagatag gcctattcaa gagccccgaa acaggcaagt acttcagagc caaggtacca      180

gacgactacc caatctgcag ctaagtcgac                                       210


