
                                SEQUENCE LISTING

<110> Ventana Medical Systems, Inc.

<120> ANTI-DNP ANTIBODIES AND METHODS OF USE
  

<130> 930136.401PC

<140> PCT                  
<141> 2009-03-06  

<160> 22

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 720
<212> DNA
<213> Rabbit

<400> 1
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc 60
acatttgccc aagtgctgac ccagactcca tcgcctgtgt ctgcagctgt gggaggcaca 120
gtcaccatca gttgccagtc cagtgagagt gtttatggta acagccgctt agcctggtat 180
cagcagaaac cagggcagtc tcccaagctc ctgatctatt atgcatccac tctggcatct 240
ggggtccctt cgcggttcaa aggcagtgga tctgggacac agttcactct caccattagc 300
gacctggagt gtgacgatgc tgcctcttac tactgtcaag gcggttatta tagtggtaat 360
cttgatgcgc ttgctttcgg cggagggacc gaggtggtgg tcagaggtga tccagttgca 420
cctactgtcc tcatcttccc accagctgct gatcaggtgg caactggaac agtcaccatc 480
gtgtgtgtgg cgaataaata ctttcccgat gtcaccgtca cctgggaggt ggatggcacc 540
acccaaacaa ctggcatcga gaacagtaaa acaccgcaga attctgcaga ttgtacctac 600
aacctcagca gcactctgac actgaccagc acacagtaca acagccacaa agagtacacc 660
tgcaaggtga cccagggcac gacctcagtc gtccagagct tcaatagggg tgactgttag 720


<210> 2
<211> 239
<212> PRT
<213> Rabbit

<400> 2
Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp
 1               5                  10                  15      
Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Pro
            20                  25                  30          
Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser
        35                  40                  45              
Glu Ser Val Tyr Gly Asn Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro
    50                  55                  60                  
Gly Gln Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Leu Ala Ser
65                  70                  75                  80  
Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr
                85                  90                  95      
Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Ser Tyr Tyr Cys
            100                 105                 110         
Gln Gly Gly Tyr Tyr Ser Gly Asn Leu Asp Ala Leu Ala Phe Gly Gly
        115                 120                 125             
Gly Thr Glu Val Val Val Arg Gly Asp Pro Val Ala Pro Thr Val Leu
    130                 135                 140                 
Ile Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile
145                 150                 155                 160 
Val Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu
                165                 170                 175     
Val Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro
            180                 185                 190         
Gln Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu
        195                 200                 205             
Thr Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr
    210                 215                 220                 
Gln Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys
225                 230                 235                 


<210> 3
<211> 1410
<212> DNA
<213> Rabbit

<400> 3
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag 60
cagctggagc agtccggagg aggagccgaa ggaggcctgg tcaagcctgg gggatccctg 120
gaactctgct gcaaagcctc tggattctcc ctcagtagta gctactgcat atgttgggtc 180
cgccaggctc cagggaaggg gctggagtgg atcggatgca tttatgctgg tagtagtggt 240
agcacttact acgcgagctg ggtgaatggc cgattcactc tctccagaga cattgaccag 300
agcacaggtt gcctacaact gaacagtctg acagccgcgg acacggccat gtattactgt 360
gcgagagccc cctatagtag tggctgggtc ctctacttta acttgtgggg cccaggcacc 420
ctggtcattg tctcctcagg gcaacctaag gctccatcag tcttcccact ggccccctgc 480
tgcggggaca cacccagctc cacggtgacc ctgggctgcc tggtcaaagg ctacctcccg 540
gagccagtga ccgtgacctg gaactcgggc accctcacca atggggtacg caccttcccg 600
tccgtccggc agtcctcagg cctctactcg ctgagcagcg tggtgagcgt gacctcaagc 660
agccagcccg tcacctgcaa cgtggcccac ccagccacca acaccaaagt ggacaagacc 720
gttgcgccct cgacatgcag caagcccacg tgcccacccc ctgaactcct ggggggaccg 780
tctgtcttca tcttcccccc aaaacccaag gacaccctca tgatctcacg cacccccgag 840
gtcacatgcg tggtggtgga cgtgagccag gatgaccccg aggtgcagtt cacatggtac 900
ataaacaacg agcaggtgcg caccgcccgg ccgccgctac gggagcagca gttcaacagc 960
acgatccgcg tggtcagcac cctccccatc gcgcaccagg actggctgag gggcaaggag 1020
ttcaagtgca aagtccacaa caaggcactc ccggccccca tcgagaaaac catctccaaa 1080
gccagagggc agcccctgga gccgaaggtc tacaccatgg gccctccccg ggaggagctg 1140
agcagcaggt cggtcagcct gacctgcatg atcaacggct tttacccttc cgacatctcg 1200
gtggagtggg agaagaacgg gaaggcagag gacaactaca agaccacgcc ggccgtgctg 1260
gacagcgacg gctcctactt cctctacagc aagctctcag tgcccacgag tgagtggcag 1320
cggggcgacg tcttcacctg ctccgtgatg cacgaggcct tgcacaacca ctacacgcag 1380
aagtccatct cccgctctcc gggtaaatga                                  1410

<210> 4
<211> 469
<212> PRT
<213> Rabbit

<400> 4
Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly
 1               5                  10                  15      
Val Gln Cys Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly
            20                  25                  30          
Leu Val Lys Pro Gly Gly Ser Leu Glu Leu Cys Cys Lys Ala Ser Gly
        35                  40                  45              
Phe Ser Leu Ser Ser Ser Tyr Cys Ile Cys Trp Val Arg Gln Ala Pro
    50                  55                  60                  
Gly Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly Ser Ser Gly
65                  70                  75                  80  
Ser Thr Tyr Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Leu Ser Arg
                85                  90                  95      
Asp Ile Asp Gln Ser Thr Gly Cys Leu Gln Leu Asn Ser Leu Thr Ala
            100                 105                 110         
Ala Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ala Pro Tyr Ser Ser Gly
        115                 120                 125             
Trp Val Leu Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Ile Val
    130                 135                 140                 
Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys
145                 150                 155                 160 
Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys
                165                 170                 175     
Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu
            180                 185                 190         
Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu
        195                 200                 205             
Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val
    210                 215                 220                 
Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr
225                 230                 235                 240 
Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu
                245                 250                 255     
Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr
            260                 265                 270         
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        275                 280                 285             
Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu
    290                 295                 300                 
Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser
305                 310                 315                 320 
Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu
                325                 330                 335     
Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala
            340                 345                 350         
Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro
        355                 360                 365             
Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser
    370                 375                 380                 
Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser
385                 390                 395                 400 
Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr
                405                 410                 415     
Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu
            420                 425                 430         
Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser
        435                 440                 445             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser
    450                 455                 460                 
Arg Ser Pro Gly Lys
465                 


<210> 5
<211> 345
<212> DNA
<213> Rabbit

<400> 5
acatttgccc aagtgctgac ccagactcca tcgcctgtgt ctgcagctgt gggaggcaca 60
gtcaccatca gttgccagtc cagtgagagt gtttatggta acagccgctt agcctggtat 120
cagcagaaac cagggcagtc tcccaagctc ctgatctatt atgcatccac tctggcatct 180
ggggtccctt cgcggttcaa aggcagtgga tctgggacac agttcactct caccattagc 240
gacctggagt gtgacgatgc tgcctcttac tactgtcaag gcggttatta tagtggtaat 300
cttgatgcgc ttgctttcgg cggagggacc gaggtggtgg tcaga                 345

<210> 6
<211> 115
<212> PRT
<213> Rabbit

<400> 6
Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala
 1               5                  10                  15      
Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr
            20                  25                  30          
Gly Asn Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser
    50                  55                  60                  
Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Asp Leu Glu Cys Asp Asp Ala Ala Ser Tyr Tyr Cys Gln Gly Gly Tyr
                85                  90                  95      
Tyr Ser Gly Asn Leu Asp Ala Leu Ala Phe Gly Gly Gly Thr Glu Val
            100                 105                 110         
Val Val Arg
        115 


<210> 7
<211> 405
<212> DNA
<213> Rabbit

<400> 7
cagcagctgg agcagtccgg aggaggagcc gaaggaggcc tggtcaagcc tgggggatcc 60
ctggaactct gctgcaaagc ctctggattc tccctcagta gtagctactg catatgttgg 120
gtccgccagg ctccagggaa ggggctggag tggatcggat gcatttatgc tggtagtagt 180
ggtagcactt actacgcgag ctgggtgaat ggccgattca ctctctccag agacattgac 240
cagagcacag gttgcctaca actgaacagt ctgacagccg cggacacggc catgtattac 300
tgtgcgagag ccccctatag tagtggctgg gtcctctact ttaacttgtg gggcccaggc 360
accctggtca ttgtctcctc agggcaacct aaggctccat cagtc                 405

<210> 8
<211> 135
<212> PRT
<213> Rabbit

<400> 8
Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu Val Lys
 1               5                  10                  15      
Pro Gly Gly Ser Leu Glu Leu Cys Cys Lys Ala Ser Gly Phe Ser Leu
            20                  25                  30          
Ser Ser Ser Tyr Cys Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly
        35                  40                  45              
Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr
    50                  55                  60                  
Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Leu Ser Arg Asp Ile Asp
65                  70                  75                  80  
Gln Ser Thr Gly Cys Leu Gln Leu Asn Ser Leu Thr Ala Ala Asp Thr
                85                  90                  95      
Ala Met Tyr Tyr Cys Ala Arg Ala Pro Tyr Ser Ser Gly Trp Val Leu
            100                 105                 110         
Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Ile Val Ser Ser Gly
        115                 120                 125             
Gln Pro Lys Ala Pro Ser Val
    130                 135 


<210> 9
<211> 19
<212> PRT
<213> Rabbit

<400> 9
Pro Asn Ser Ala Ser His Ser Gly Ser Ala Pro Asn Thr Ser Ser Ala
 1               5                  10                  15      
Pro Gly Ser
            


<210> 10
<211> 807
<212> DNA
<213> Rabbit

<400> 10
acttttgctc aagttttgac tcaaactcca tctccagttt ctgctgctgt tggtggtact 60
gttactattt cttgtcaatc ttctgaatct gtttacggta actccagatt ggcttggtat 120
caacaaaagc caggtcaatc tccaaagttg ttgatttact acgcttctac tttggcttct 180
ggtgttccat ccagatttaa gggttctggt tctggtactc aatttacttt gactatttct 240
gatttggaat gtgatgatgc tgcttcttac tactgtcaag gtggttacta ctctggtaac 300
ttggatgctt tggcttttgg tggtggtact gaagttgttg ttagaccaaa ctctgcttct 360
cattctggtt ctgctccaaa cacttcttct gctccaggtt ctcaacaatt ggaacaatct 420
ggtggtggag ctgaaggtgg tttggttaag ccaggtggtt ctttggaatt gtgttgtaag 480
gcttctggtt tttctttgtc ctcttcttac tgtatttgtt gggttagaca agctccaggt 540
aagggtttgg aatggattgg ttgcatttac gctggttctt ccggttctac ttactatgct 600
tcttgggtta atggtagatt tactttgtcc agagacattg atcaatctac tggttgtttg 660
caattgaact ctttgactgc tgctgatact gcaatgtact actgtgctag agcaccttac 720
tcttccggtt gggttttgta ctttaacttg tggggtccag gtactttggt tattgtttct 780
tctggtcagc caaaggctcc atctgtt                                     807

<210> 11
<211> 269
<212> PRT
<213> Rabbit

<400> 11
Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala
 1               5                  10                  15      
Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr
            20                  25                  30          
Gly Asn Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro
        35                  40                  45              
Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser
    50                  55                  60                  
Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Asp Leu Glu Cys Asp Asp Ala Ala Ser Tyr Tyr Cys Gln Gly Gly Tyr
                85                  90                  95      
Tyr Ser Gly Asn Leu Asp Ala Leu Ala Phe Gly Gly Gly Thr Glu Val
            100                 105                 110         
Val Val Arg Pro Asn Ser Ala Ser His Ser Gly Ser Ala Pro Asn Thr
        115                 120                 125             
Ser Ser Ala Pro Gly Ser Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala
    130                 135                 140                 
Glu Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Glu Leu Cys Cys Lys
145                 150                 155                 160 
Ala Ser Gly Phe Ser Leu Ser Ser Ser Tyr Cys Ile Cys Trp Val Arg
                165                 170                 175     
Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly
            180                 185                 190         
Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr
        195                 200                 205             
Leu Ser Arg Asp Ile Asp Gln Ser Thr Gly Cys Leu Gln Leu Asn Ser
    210                 215                 220                 
Leu Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ala Pro Tyr
225                 230                 235                 240 
Ser Ser Gly Trp Val Leu Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu
                245                 250                 255     
Val Ile Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val
            260                 265                 


<210> 12
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 12
ggatccatgg acacgagggc ccccactcag                                  30

<210> 13
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 13
gtcgacctaa cagtcacccc tattgaagct ctggac                           36

<210> 14
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 14
gtcgacctag gagcattctg caggggccag                                  30

<210> 15
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 15
ggatccatgg cctgcacccc gctcctc                                     27

<210> 16
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 16
ggatccatgg agactgggct gcgctggctt                                  30

<210> 17
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<220> 
<221> misc_feature   
<222> 36, 37
<223> n = Any nucleotide

<400> 17
tttttttttt tttttttttt tttttttttt tttttnn                          37

<210> 18
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 18
gatcggtacc gccaccatgg agactgggct gcgctggctt ctcctggtcg c          51

<210> 19
<211> 52
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 19
gatcggtacc gccaccatgg acacgagggc ccccactcag ctgctggggc tc         52

<210> 20
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 20
gatcgatatc gccaccatgg agactgggct gcgctggctt ctcctggtcg c          51

<210> 21
<211> 52
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 21
gatcgatatc gccaccatgg acacgagggc ccccactcag ctgctggggc tc         52

<210> 22
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 22
cgtcgagggc ctctgccagt gtcgaacaga cattc                            35
