                               SEQUENCE LISTING

<110> WYETH 
 
<120> CELL-BASED METHODS FOR DETECTING AND/OR MEASURING
      BMP-12-RELATED PROTEIN ACTIVITY

<130> 08702.0224-00304

<140>
<141>

<150> 61/032,525
<151> 2008-02-29

<160> 22    

<170> PatentIn version 3.5

<210> 1
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 1
tttgcgaaac accattgctg aat                                               23


<210> 2
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 2
gcaccagtgt gtttggagtt g                                                 21


<210> 3
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 3
ccaagcttgt ggtcctc                                                      17


<210> 4
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 4
gcatgcgcag tgcattga                                                     18


<210> 5
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 5
ccacatcctt tccacagaca tagc                                              24


<210> 6
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 6
caccacacac acacgtc                                                      17


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 7
gactcctgtg acaccaacca                                                   20


<210> 8
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 8
gctgggagct gttaatgact gt                                                22


<210> 9
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 9
catccccgtc actgtct                                                      17


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 10
gctcagatcg accccaactg                                                   20


<210> 11
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 11
tcccttcaaa gtcaactccg ttaaa                                             25


<210> 12
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 12
ccgtgtaccc aacagc                                                       16


<210> 13
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 13
actcggtgcg caacct                                                       16


<210> 14
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 14
caattcaatg gactctgggt tctg                                              24


<210> 15
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 15
ccccagagcc ttttct                                                       16


<210> 16
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 16
cggccctgag tctgacaaa                                                    19


<210> 17
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 17
gccggagtct gttcactacc tt                                                22


<210> 18
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"

<400> 18
ccttcatgtc caagcaggag ggca                                              24


<210> 19
<211> 961
<212> PRT
<213> Homo sapiens

<400> 19
Met Leu Ala Pro Arg Gly Ala Ala Val Leu Leu Leu His Leu Val Leu 
1               5                   10                  15      


Gln Arg Trp Leu Ala Ala Gly Ala Gln Ala Thr Pro Gln Val Phe Asp 
            20                  25                  30          


Leu Leu Pro Ser Ser Ser Gln Arg Leu Asn Pro Gly Ala Leu Leu Pro 
        35                  40                  45              


Val Leu Thr Asp Pro Ala Leu Asn Asp Leu Tyr Val Ile Ser Thr Phe 
    50                  55                  60                  


Lys Leu Gln Thr Lys Ser Ser Ala Thr Ile Phe Gly Leu Tyr Ser Ser 
65                  70                  75                  80  


Thr Asp Asn Ser Lys Tyr Phe Glu Phe Thr Val Met Gly Arg Leu Asn 
                85                  90                  95      


Lys Ala Ile Leu Arg Tyr Leu Lys Asn Asp Gly Lys Val His Leu Val 
            100                 105                 110         


Val Phe Asn Asn Leu Gln Leu Ala Asp Gly Arg Arg His Arg Ile Leu 
        115                 120                 125             


Leu Arg Leu Ser Asn Leu Gln Arg Gly Ala Gly Ser Leu Glu Leu Tyr 
    130                 135                 140                 


Leu Asp Cys Ile Gln Val Asp Ser Val His Asn Leu Pro Arg Ala Phe 
145                 150                 155                 160 


Ala Gly Pro Ser Gln Lys Pro Glu Thr Ile Glu Leu Arg Thr Phe Gln 
                165                 170                 175     


Arg Lys Pro Gln Asp Phe Leu Glu Glu Leu Lys Leu Val Val Arg Gly 
            180                 185                 190         


Ser Leu Phe Gln Val Ala Ser Leu Gln Asp Cys Phe Leu Gln Gln Ser 
        195                 200                 205             


Glu Pro Leu Ala Ala Thr Gly Thr Gly Asp Phe Asn Arg Gln Phe Leu 
    210                 215                 220                 


Gly Gln Met Thr Gln Leu Asn Gln Leu Leu Gly Glu Val Lys Asp Leu 
225                 230                 235                 240 


Leu Arg Gln Gln Val Lys Glu Thr Ser Phe Leu Arg Asn Thr Ile Ala 
                245                 250                 255     


Glu Cys Gln Ala Cys Gly Pro Leu Lys Phe Gln Ser Pro Thr Pro Ser 
            260                 265                 270         


Thr Val Val Pro Pro Ala Pro Pro Ala Pro Pro Thr Arg Pro Pro Arg 
        275                 280                 285             


Arg Cys Asp Ser Asn Pro Cys Phe Arg Gly Val Gln Cys Thr Asp Ser 
    290                 295                 300                 


Arg Asp Gly Phe Gln Cys Gly Pro Cys Pro Glu Gly Tyr Thr Gly Asn 
305                 310                 315                 320 


Gly Ile Thr Cys Ile Asp Val Asp Glu Cys Lys Tyr His Pro Cys Tyr 
                325                 330                 335     


Pro Gly Val His Cys Ile Asn Leu Ser Pro Gly Phe Arg Cys Asp Ala 
            340                 345                 350         


Cys Pro Val Gly Phe Thr Gly Pro Met Val Gln Gly Val Gly Ile Ser 
        355                 360                 365             


Phe Ala Lys Ser Asn Lys Gln Val Cys Thr Asp Ile Asp Glu Cys Arg 
    370                 375                 380                 


Asn Gly Ala Cys Val Pro Asn Ser Ile Cys Val Asn Thr Leu Gly Ser 
385                 390                 395                 400 


Tyr Arg Cys Gly Pro Cys Lys Pro Gly Tyr Thr Gly Asp Gln Ile Arg 
                405                 410                 415     


Gly Cys Lys Ala Glu Arg Asn Cys Arg Asn Pro Glu Leu Asn Pro Cys 
            420                 425                 430         


Ser Val Asn Ala Gln Cys Ile Glu Glu Arg Gln Gly Asp Val Thr Cys 
        435                 440                 445             


Val Cys Gly Val Gly Trp Ala Gly Asp Gly Tyr Ile Cys Gly Lys Asp 
    450                 455                 460                 


Val Asp Ile Asp Ser Tyr Pro Asp Glu Glu Leu Pro Cys Ser Ala Arg 
465                 470                 475                 480 


Asn Cys Lys Lys Asp Asn Cys Lys Tyr Val Pro Asn Ser Gly Gln Glu 
                485                 490                 495     


Asp Ala Asp Arg Asp Gly Ile Gly Asp Ala Cys Asp Glu Asp Ala Asp 
            500                 505                 510         


Gly Asp Gly Ile Leu Asn Glu Gln Asp Asn Cys Val Leu Ile His Asn 
        515                 520                 525             


Val Asp Gln Arg Asn Ser Asp Lys Asp Ile Phe Gly Asp Ala Cys Asp 
    530                 535                 540                 


Asn Cys Leu Ser Val Leu Asn Asn Asp Gln Lys Asp Thr Asp Gly Asp 
545                 550                 555                 560 


Gly Arg Gly Asp Ala Cys Asp Asp Asp Met Asp Gly Asp Gly Ile Lys 
                565                 570                 575     


Asn Ile Leu Asp Asn Cys Pro Lys Phe Pro Asn Arg Asp Gln Arg Asp 
            580                 585                 590         


Lys Asp Gly Asp Gly Val Gly Asp Ala Cys Asp Ser Cys Pro Asp Val 
        595                 600                 605             


Ser Asn Pro Asn Gln Ser Asp Val Asp Asn Asp Leu Val Gly Asp Ser 
    610                 615                 620                 


Cys Asp Thr Asn Gln Asp Ser Asp Gly Asp Gly His Gln Asp Ser Thr 
625                 630                 635                 640 


Asp Asn Cys Pro Thr Val Ile Asn Ser Ala Gln Leu Asp Thr Asp Lys 
                645                 650                 655     


Asp Gly Ile Gly Asp Glu Cys Asp Asp Asp Asp Asp Asn Asp Gly Ile 
            660                 665                 670         


Pro Asp Leu Val Pro Pro Gly Pro Asp Asn Cys Arg Leu Val Pro Asn 
        675                 680                 685             


Pro Ala Gln Glu Asp Ser Asn Ser Asp Gly Val Gly Asp Ile Cys Glu 
    690                 695                 700                 


Ser Asp Phe Asp Gln Asp Gln Val Ile Asp Arg Ile Asp Val Cys Pro 
705                 710                 715                 720 


Glu Asn Ala Glu Val Thr Leu Thr Asp Phe Arg Ala Tyr Gln Thr Val 
                725                 730                 735     


Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro Asn Trp Val Val 
            740                 745                 750         


Leu Asn Gln Gly Met Glu Ile Val Gln Thr Met Asn Ser Asp Pro Gly 
        755                 760                 765             


Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val Asp Phe Glu Gly Thr 
    770                 775                 780                 


Phe His Val Asn Thr Gln Thr Asp Asp Asp Tyr Ala Gly Phe Ile Phe 
785                 790                 795                 800 


Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val Met Trp Lys Gln Thr 
                805                 810                 815     


Glu Gln Thr Tyr Trp Gln Ala Thr Pro Phe Arg Ala Val Ala Glu Pro 
            820                 825                 830         


Gly Ile Gln Leu Lys Ala Val Lys Ser Lys Thr Gly Pro Gly Glu His 
        835                 840                 845             


Leu Arg Asn Ser Leu Trp His Thr Gly Asp Thr Ser Asp Gln Val Arg 
    850                 855                 860                 


Leu Leu Trp Lys Asp Ser Arg Asn Val Gly Trp Lys Asp Lys Val Ser 
865                 870                 875                 880 


Tyr Arg Trp Phe Leu Gln His Arg Pro Gln Val Gly Tyr Ile Arg Val 
                885                 890                 895     


Arg Phe Tyr Glu Gly Ser Glu Leu Val Ala Asp Ser Gly Val Thr Ile 
            900                 905                 910         


Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val Phe Cys Phe Ser Gln 
        915                 920                 925             


Glu Asn Ile Ile Trp Ser Asn Leu Lys Tyr Arg Cys Asn Asp Thr Ile 
    930                 935                 940                 


Pro Glu Asp Phe Gln Glu Phe Gln Thr Gln Asn Phe Asp Arg Phe Asp 
945                 950                 955                 960 


Asn 
    


<210> 20
<211> 3365
<212> DNA
<213> Homo sapiens

<400> 20
ctggtccgtc caggctcctt cccatcctca cacccgcgcc tttctccctg cggccccggc       60

tcgctgctcc agctgcccag ctcttccccc gcccggccgc accataaagc gcccggccgc      120

tgccgcggag cccagcagcc agctccccag caccgcacgg cggggacgcg agcgcgcccc      180

cgacggcagc ccggacgccg agcacgggtc acctgcggcg ccggcccggg cgccgaccga      240

ggttcaacgc acggcccggg gacccccagg cggggccaac gccgccgtcg cccccggcct      300

cgcggggagc aggaagagcc aacatgctgg ccccgcgcgg agccgccgtc ctcctgctgc      360

acctggtcct gcagcggtgg ctagcggcag gcgcccaggc caccccccag gtctttgacc      420

ttctcccatc ttccagtcag aggctaaacc caggcgctct gctgccagtc ctgacagacc      480

ccgccctgaa tgatctctat gtgatttcca ccttcaagct gcagactaaa agttcagcca      540

ccatcttcgg tctttactct tcaactgaca acagtaaata ttttgaattt actgtgatgg      600

gacgcttaaa caaagccatc ctccgttacc tgaagaacga tgggaaggtg catttggtgg      660

ttttcaacaa cctgcagctg gcagacggaa ggcggcacag gatcctcctg aggctgagca      720

atttgcagcg aggggccggc tccctagagc tctacctgga ctgcatccag gtggattccg      780

ttcacaatct ccccagggcc tttgctggcc cctcccagaa acctgagacc attgaattga      840

ggactttcca gaggaagcca caggacttct tggaagagct gaagctggtg gtgagaggct      900

cactgttcca ggtggccagc ctgcaagact gcttcctgca gcagagtgag ccactggctg      960

ccacaggcac aggggacttt aaccggcagt tcttgggtca aatgacacaa ttaaaccaac     1020

tcctgggaga ggtgaaggac cttctgagac agcaggttaa ggaaacatca tttttgcgaa     1080

acaccatagc tgaatgccag gcttgcggtc ctctcaagtt tcagtctccg accccaagca     1140

cggtggtgcc cccggctccc cctgcaccgc caacacgccc acctcgtcgg tgtgactcca     1200

acccatgttt ccgaggtgtc caatgtaccg acagtagaga tggcttccag tgtgggccct     1260

gccccgaggg ctacacagga aacgggatca cctgtattga tgttgatgag tgcaaatacc     1320

atccctgcta cccgggcgtg cactgcataa atttgtctcc tggcttcaga tgtgacgcct     1380

gcccagtggg cttcacaggg cccatggtgc agggtgttgg gatcagtttt gccaagtcaa     1440

acaagcaggt ctgcactgac attgatgagt gtcgaaatgg agcgtgcgtt cccaactcga     1500

tctgcgttaa tactttggga tcttaccgct gtgggccttg taagccgggg tatactggtg     1560

atcagataag gggatgcaaa gcggaaagaa actgcagaaa cccagagctg aacccttgca     1620

gtgtgaatgc ccagtgcatt gaagagaggc agggggatgt gacatgtgtg tgtggagtcg     1680

gttgggctgg agatggctat atctgtggaa aggatgtgga catcgacagt taccccgacg     1740

aagaactgcc atgctctgcc aggaactgta aaaaggacaa ctgcaaatat gtgccaaatt     1800

ctggccaaga agatgcagac agagatggca ttggcgacgc ttgtgacgag gatgctgacg     1860

gagatgggat cctgaatgag caggataact gtgtcctgat tcataatgtg gaccaaagga     1920

acagcgataa agatatcttt ggggatgcct gtgataactg cctgagtgtc ttaaataacg     1980

accagaaaga caccgatggg gatggaagag gagatgcctg tgatgatgac atggatggag     2040

atggaataaa aaacattctg gacaactgcc caaaatttcc caatcgtgac caacgggaca     2100

aggatggtga tggtgtgggg gatgcctgtg acagttgtcc tgatgtcagc aaccctaacc     2160

agtctgatgt ggataatgat ctggttgggg actcctgtga caccaatcag gacagtgatg     2220

gagatgggca ccaggacagc acagacaact gccccaccgt cattaacagt gcccagctgg     2280

acaccgataa ggatggaatt ggtgacgagt gtgatgatga tgatgacaat gatggtatcc     2340

cagacctggt gccccctgga ccagacaact gccggctggt ccccaaccca gcccaggagg     2400

atagcaacag cgacggagtg ggagacatct gtgagtctga ctttgaccag gaccaggtca     2460

tcgatcggat cgacgtctgc ccagagaacg cagaggtcac cctgaccgac ttcagggctt     2520

accagaccgt ggtcctggat cctgaagggg atgcccagat cgatcccaac tgggtggtcc     2580

tgaaccaggg catggagatt gtacagacca tgaacagtga tcctggcctg gcagtggggt     2640

acacagcttt taatggagtt gacttcgaag ggaccttcca tgtgaatacc cagacagatg     2700

atgactatgc aggctttatc tttggctacc aagatagctc cagcttctac gtggtcatgt     2760

ggaagcagac ggagcagaca tattggcaag ccaccccatt ccgagcagtt gcagaacctg     2820

gcattcagct caaggctgtg aagtctaaga caggtccagg ggagcatctc cggaactccc     2880

tgtggcacac gggggacacc agtgaccagg tcaggctgct gtggaaggac tccaggaatg     2940

tgggctggaa ggacaaggtg tcctaccgct ggttcctaca gcacaggccc caggtgggct     3000

acatcagggt acgattttat gaaggctctg agttggtggc tgactctggc gtcaccatag     3060

acaccacaat gcgtggaggc cgacttggcg ttttctgctt ctctcaagaa aacatcatct     3120

ggtccaacct caagtatcgc tgcaatgaca ccatccctga ggacttccaa gagtttcaaa     3180

cccagaattt cgaccgcttc gataattaaa ccaaggaagc aatctgtaac tgcttttcgg     3240

aacactaaaa ccatatatat tttaacttca attttcttta gcttttacca acccaaatat     3300

atcaaaacgt tttatgtgaa tgtggcaata aaggagaaga gatcattttt aaaaaaaaaa     3360

aaaaa                                                                 3365


<210> 21
<211> 963
<212> PRT
<213> Mus musculus

<400> 21
Met Pro Ala Pro Arg Ala Ala Ala Ala Ala Phe Leu Leu Leu His Leu 
1               5                   10                  15      


Val Leu Gln Pro Trp Gln Arg Thr Ser Ala Gln Ala Thr Pro Gln Val 
            20                  25                  30          


Phe Asp Leu Leu Pro Ser Ser Ser Gln Arg Leu Asn Pro Ser Ala Leu 
        35                  40                  45              


Gln Pro Val Leu Thr Asp Pro Thr Leu His Glu Val Tyr Leu Ile Ser 
    50                  55                  60                  


Thr Phe Lys Leu Gln Ser Lys Ser Ser Ala Thr Ile Phe Gly Leu Tyr 
65                  70                  75                  80  


Ser Ser Ser Asp Asn Ser Lys Tyr Phe Glu Phe Thr Val Met Gly Arg 
                85                  90                  95      


Leu Asn Lys Ala Ile Leu Arg Tyr Leu Lys Asn Asp Gly Lys Ile His 
            100                 105                 110         


Leu Val Val Phe Asn Asn Leu Gln Leu Ala Asp Gly Arg Arg His Arg 
        115                 120                 125             


Val Leu Leu Arg Leu Ser Asn Leu Gln Arg Gly Asp Gly Ser Val Glu 
    130                 135                 140                 


Leu Tyr Leu Asp Cys Ala Gln Ala Asp Ser Val Arg Asn Leu Pro Arg 
145                 150                 155                 160 


Ala Phe Ser Gly Leu Thr Gln Asn Pro Glu Ser Ile Glu Leu Arg Thr 
                165                 170                 175     


Phe Gln Arg Lys Pro Gln Asp Phe Leu Glu Glu Leu Lys Leu Val Val 
            180                 185                 190         


Arg Gly Ser Leu Phe Gln Val Ala Ser Leu Gln Asp Cys Phe Leu Gln 
        195                 200                 205             


Gln Ser Glu Pro Leu Ala Ala Thr Ser Thr Gly Asp Phe Asn Arg Gln 
    210                 215                 220                 


Phe Leu Gly Gln Met Thr Gln Leu Asn Gln Leu Leu Gly Glu Val Lys 
225                 230                 235                 240 


Asp Leu Leu Arg Gln Gln Val Lys Glu Thr Ser Phe Leu Arg Asn Thr 
                245                 250                 255     


Ile Ala Glu Cys Gln Ala Cys Gly Pro Leu Ser Phe Gln Ser Pro Thr 
            260                 265                 270         


Pro Asn Thr Leu Val Pro Ile Ala Pro Pro Ala Pro Pro Thr Arg Pro 
        275                 280                 285             


Thr Arg His Cys Asp Ser Ser Pro Cys Phe Arg Gly Val Arg Cys Thr 
    290                 295                 300                 


Asp Thr Arg Asp Gly Phe Gln Cys Gly Pro Cys Pro Asp Gly Tyr Thr 
305                 310                 315                 320 


Gly Asn Gly Ile Thr Cys Ser Asp Val Asp Glu Cys Lys Tyr His Pro 
                325                 330                 335     


Cys Tyr Pro Gly Val Arg Cys Val Asn Leu Ala Pro Gly Phe Arg Cys 
            340                 345                 350         


Asp Ala Cys Pro Val Gly Phe Thr Gly Pro Met Val Gln Gly Val Gly 
        355                 360                 365             


Ile Asn Phe Ala Lys Thr Asn Lys Gln Val Cys Thr Asp Val Asp Glu 
    370                 375                 380                 


Cys Gln Asn Gly Ala Cys Val Leu Asn Ser Ile Cys Ile Asn Thr Leu 
385                 390                 395                 400 


Gly Ser Tyr Arg Cys Gly Pro Cys Lys Pro Gly Tyr Thr Gly Asp Gln 
                405                 410                 415     


Thr Arg Gly Cys Lys Thr Glu Arg Ser Cys Arg Asn Pro Glu Gln Asn 
            420                 425                 430         


Pro Cys Ser Val His Ala Gln Cys Ile Glu Glu Arg Gln Gly Asp Val 
        435                 440                 445             


Thr Cys Val Cys Gly Val Gly Trp Ala Gly Asp Gly Tyr Val Cys Gly 
    450                 455                 460                 


Lys Asp Val Asp Ile Asp Ser Tyr Pro Asp Glu Glu Leu Pro Cys Ser 
465                 470                 475                 480 


Ala Arg Asn Cys Lys Lys Asp Asn Cys Lys Tyr Val Pro Asn Ser Gly 
                485                 490                 495     


Gln Glu Asp Ala Asp Arg Asp Gly Ile Gly Asp Ala Cys Asp Glu Asp 
            500                 505                 510         


Ala Asp Gly Asp Gly Ile Leu Asn Glu Gln Asp Asn Cys Val Leu Thr 
        515                 520                 525             


His Asn Ile Asp Gln Arg Asn Ser Asp Lys Asp Ile Phe Gly Asp Ala 
    530                 535                 540                 


Cys Asp Asn Cys Arg Met Val Leu Asn Asn Asp Gln Lys Asp Thr Asp 
545                 550                 555                 560 


Gly Asp Gly Arg Gly Asp Ala Cys Asp Asp Asp Met Asp Gly Asp Gly 
                565                 570                 575     


Ile Lys Asn Ile Leu Asp Asn Cys Pro Arg Val Pro Asn Arg Asp Gln 
            580                 585                 590         


Gln Asp Arg Asp Gly Asp Asp Val Gly Asp Ala Cys Asp Ser Cys Pro 
        595                 600                 605             


Asp Val Ser Asn Pro Asn Gln Ser Asp Val Asp Asn Asp Leu Val Gly 
    610                 615                 620                 


Asp Ser Cys Asp Thr Asn Gln Asp Ser Asp Gly Asp Gly His Gln Asp 
625                 630                 635                 640 


Ser Thr Asp Asn Cys Pro Thr Val Ile Asn Ser Ser Gln Leu Asp Thr 
                645                 650                 655     


Asp Lys Asp Gly Ile Gly Asp Glu Cys Asp Asp Asp Asp Asp Asn Asp 
            660                 665                 670         


Gly Ile Pro Asp Leu Val Pro Pro Gly Pro Asp Asn Cys Arg Leu Val 
        675                 680                 685             


Pro Asn Pro Ala Gln Glu Asp Ser Asn Asn Asp Gly Val Gly Asp Ile 
    690                 695                 700                 


Cys Glu Ala Asp Phe Asp Gln Asp Gln Val Ile Asp His Ile Asp Val 
705                 710                 715                 720 


Cys Pro Glu Asn Ala Glu Ile Thr Leu Thr Asp Phe Arg Ala Tyr Gln 
                725                 730                 735     


Thr Val Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro Asn Trp 
            740                 745                 750         


Val Val Leu Asn Gln Gly Met Glu Ile Val Gln Thr Met Asn Ser Asp 
        755                 760                 765             


Pro Gly Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val Asp Phe Glu 
    770                 775                 780                 


Gly Thr Phe His Val Asn Thr Gln Thr Asp Asp Asp Tyr Ala Gly Phe 
785                 790                 795                 800 


Ile Phe Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val Met Trp Lys 
                805                 810                 815     


Gln Thr Glu Gln Thr Tyr Trp Gln Ala Thr Pro Phe Arg Ala Val Ala 
            820                 825                 830         


Glu Pro Gly Ile Gln Leu Lys Ala Val Lys Ser Lys Thr Gly Pro Gly 
        835                 840                 845             


Glu His Leu Arg Asn Ser Leu Trp His Thr Gly Asp Thr Ser Asp Gln 
    850                 855                 860                 


Val Arg Leu Leu Trp Lys Asp Ser Arg Asn Val Gly Trp Lys Asp Lys 
865                 870                 875                 880 


Val Ser Tyr Arg Trp Phe Leu Gln His Arg Pro Gln Val Gly Tyr Ile 
                885                 890                 895     


Arg Val Arg Phe Tyr Glu Gly Ser Glu Leu Val Ala Asp Ser Gly Val 
            900                 905                 910         


Thr Ile Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val Phe Cys Phe 
        915                 920                 925             


Ser Gln Glu Asn Ile Ile Trp Ser Asn Leu Lys Tyr Arg Cys Asn Asp 
    930                 935                 940                 


Thr Ile Pro Glu Asp Phe Gln Glu Phe Gln Thr Gln Ser Phe Asp Arg 
945                 950                 955                 960 


Leu Asp Asn 
            


<210> 22
<211> 3159
<212> DNA
<213> Mus musculus

<400> 22
cccgaggcca gcaaacagcg ccctacgccg gcaaagccac gccacattgt cgcctgcaca       60

gccctcaggg agcagaagag tcaccatgcc ggccccacgc gcggccgcgg ccgccttcct      120

cctgctgcac ctggtcctgc agccgtggca gcggacgagc gcccaggcca caccccaggt      180

ctttgatctt ctaccgtcct ccagccagag gctgaacccc agcgccctgc agccagtcct      240

gacagatccc accctgcacg aagtctatct catctccacc ttcaagctgc agagtaaaag      300

ctcagccacc atctttggcc tctactcctc aagtgacaac agcaaatact ttgaattcac      360

tgtgatggga cggctgaaca aagccatcct ccgctacctg aagaatgatg gaaagatcca      420

tctggtggtg ttcaacaact tgcagctggc tgatgggagg cgccacaggg ttctcctgag      480

actgagcaat ttgcagagag gagatggctc tgtagaactc tacctggact gcgctcaggc      540

ggactcggtg cgcaacctcc ccagagcctt ttctggcctc acccagaacc cagagtccat      600

tgaattgcgg acattccaga ggaagcccca ggacttcttg gaagagctga agctggtggt      660

gcggggctcg ctgttccagg tggccagcct ccaagactgc ttcctgcagc agagtgagcc      720

tctggctgcc acaagcacag gagactttaa tcgacagttc ttgggtcaaa tgacacaact      780

gaaccagctc cttggagagg tgaaagatct tctgaggcag caggtcaagg aaacatcgtt      840

tttgcgaaac accattgctg aatgccaagc ttgtggtcct ctcagctttc agtccccaac      900

tccaaacaca ctggtgccca tagctcctcc agcaccccca actcgcccaa cacgccactg      960

tgactccagc ccttgtttcc gaggtgtccg atgtacggac accagggatg gcttccagtg     1020

tggaccctgc ccagatggtt acacgggaaa cgggatcacc tgctctgacg tggatgagtg     1080

caaataccat ccctgctatc caggtgtgcg ctgtgtgaat ttggctccgg gtttcagatg     1140

tgacgcctgt ccagtaggtt tcacagggcc catggtgcag ggtgtcggga tcaactttgc     1200

taaaacaaac aagcaggtgt gcactgatgt tgatgagtgt cagaatggag cgtgtgttct     1260

gaattctatc tgcattaaca ctttgggatc ttatcgctgt gggccttgca aaccagggta     1320

cactggtgat cagacgaggg gatgcaagac tgaaaggagc tgccggaacc cagagcagaa     1380

cccatgcagt gtgcatgcgc agtgcattga ggagcggcaa ggggatgtga cgtgtgtgtg     1440

tggtgttggc tgggctggtg acggctatgt ctgtggaaag gatgtggaca ttgacagtta     1500

ccctgatgaa gaactgccat gctctgccag gaactgcaag aaggataact gcaagtatgt     1560

gccaaactct ggccaggaag atgcagacag agatggcatc ggagacgcgt gtgatgagga     1620

tgcagatgga gatgggatct tgaatgaaca ggacaactgt gtcctgactc acaatataga     1680

ccaaaggaac agtgataaag atatctttgg ggatgcctgt gacaactgcc ggatggtcct     1740

gaataatgac cagaaggata ctgacgggga tgggagagga gacgcctgtg atgacgacat     1800

ggatggagat ggaataaaaa acattttgga caactgtccc agagttccca accgtgacca     1860

gcaggatcgg gatggtgatg atgtcggaga cgcttgtgac agctgtcctg atgtcagtaa     1920

ccctaaccag tcggatgtgg ataacgatct ggttggggac tcctgtgaca ccaaccaaga     1980

cagtgacggg gatggccacc aggacagcac agacaactgc cccacagtca ttaacagctc     2040

ccagctggac actgacaaag atgggatcgg cgatgaatgt gatgacgatg acgataacga     2100

tggcatccca gacctggtgc ctcctggccc agacaactgc aggctcgtcc ccaacccagc     2160

ccaggaagat agcaacaatg acggggtagg agatatctgt gaagctgact tcgaccagga     2220

ccaggtcatc gatcacattg atgtgtgccc tgagaatgcg gagatcaccc tgactgactt     2280

cagggcctac cagacagtgg tcctggaccc tgaaggggat gctcagatcg accccaactg     2340

ggtggtcctg aaccagggca tggaaattgt gcagaccatg aacagtgacc ctggcctagc     2400

tgttgggtac acggcattta acggagttga ctttgaaggg accttccacg taaacaccca     2460

gacagatgat gactatgctg gctttatttt tggttaccaa gacagctcca gcttctatgt     2520

agtcatgtgg aagcaaacgg agcagacata ctggcaggct acaccgttcc gtgcagtagc     2580

agaacctggt attcagctca aggctgtgaa gtctaaaact ggcccagggg aacatctccg     2640

aaactccctg tggcacacag gggacaccag cgaccaggtc aggctgctgt ggaaggactc     2700

caggaatgtg ggctggaagg acaaggtctc ctaccgctgg ttcctgcagc ataggcccca     2760

ggtgggctac atcagggtgc gcttttatga aggctcggag ttggtggctg actctggggt     2820

caccatagac accaccatgc gtggaggccg acttggtgtg ttctgcttct ctcaagaaaa     2880

catcatctgg tccaacctca agtaccgctg caacgacacc ataccagagg acttccagga     2940

gttccagacc cagagttttg accgcttgga taattgagcc aagaagcaat cccacaactg     3000

ccttctcaaa caccaaagca acatcttttt taaaacttcc tataattctc tttatattat     3060

catggctttt cttttaccag cccaaatacg tcaaaacttt ttatatgaat gtggaaataa     3120

agaagagact atttctaata agaaaaaaaa aaaaaaaaa                            3159


