
                                SEQUENCE LISTING

<110> ZHA, Dongxing
      WILDT, Stefan

<120> SURFACE DISPLAY OF RECOMBINANT PROTEINS
  IN LOWER EUKARYOTES

<130> GFI-BIO-0031

<150> 61/067,965          
<151> 2008-03-03  

<160> 74

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> c-fos zipper

<400> 1
Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys Ser Ala Leu Gln
 1               5                  10                  15      
Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys Leu
            20                  25                  


<210> 2
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> c-jun zipper

<400> 2
Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala
 1               5                  10                  15      
Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln Leu
            20                  25                  


<210> 3
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> c-fos zipper

<400> 3
Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys
 1               5                  10                  15      
Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys
            20                  25                  30          
Leu Glu Phe Ile Leu Ala
        35              


<210> 4
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> c-jun zipper

<400> 4
Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn
 1               5                  10                  15      
Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln
            20                  25                  30          
Leu Lys Gln Lys Val Met Asn
        35                  


<210> 5
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> c-jun zipper

<400> 5
Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala
 1               5                  10                  15      
Ser Thr Phe Asn Met Leu Arg Glu Gln Phe Ala Gln Leu
            20                  25                  


<210> 6
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> c-jun zipper

<400> 6
Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala
 1               5                  10                  15      
Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln Phe
            20                  25                  


<210> 7
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> c-jun zipper

<400> 7
Leu Glu Glu Lys Val Lys Thr Phe Lys Ala Gln Asn Ser Glu Leu Ala
 1               5                  10                  15      
Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln Phe
            20                  25                  


<210> 8
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> c-jun zipper

<400> 8
Leu Glu Glu Lys Val Lys Ser Phe Lys Ala Gln Asn Ser Glu His Ala
 1               5                  10                  15      
Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln Leu
            20                  25                  


<210> 9
<211> 74
<212> PRT
<213> Artificial Sequence

<220> 
<223> S.cerevisiae CWP2

<400> 9
Val Asp Glu Ser Ala Ala Ala Ile Ser Gln Ile Thr Asp Gly Gln Ile
 1               5                  10                  15      
Gln Ala Thr Thr Thr Ala Thr Thr Glu Ala Thr Thr Thr Ala Ala Pro
            20                  25                  30          
Ser Ser Thr Val Glu Thr Val Ser Pro Ser Ser Thr Glu Thr Ile Ser
        35                  40                  45              
Gln Gln Thr Glu Asn Gly Ala Ala Lys Ala Ala Val Gly Met Gly Ala
    50                  55                  60                  
Gly Ala Leu Ala Ala Ala Ala Met Leu Leu
65                  70                  


<210> 10
<211> 54
<212> PRT
<213> Artificial Sequence

<220> 
<223> S.cerevisiae CWP2 truncated version

<400> 10
Val Asp Thr Thr Glu Ala Thr Thr Thr Ala Ala Pro Ser Ser Thr Val
 1               5                  10                  15      
Glu Thr Val Ser Pro Ser Ser Thr Glu Thr Ile Ser Gln Gln Thr Glu
            20                  25                  30          
Asn Gly Ala Ala Lys Ala Ala Val Gly Met Gly Ala Gly Ala Leu Ala
        35                  40                  45              
Ala Ala Ala Met Leu Leu
    50                  


<210> 11
<211> 322
<212> PRT
<213> Artificial Sequence

<220> 
<223> S. cerevisiae SED1

<400> 11
Val Asp Gln Phe Ser Asn Ser Thr Ser Ala Ser Ser Thr Asp Val Thr
 1               5                  10                  15      
Ser Ser Ser Ser Ile Ser Thr Ser Ser Gly Ser Val Thr Ile Thr Ser
            20                  25                  30          
Ser Glu Ala Pro Glu Ser Asp Asn Gly Thr Ser Thr Ala Ala Pro Thr
        35                  40                  45              
Glu Thr Ser Thr Glu Ala Pro Thr Thr Ala Ile Pro Thr Asn Gly Thr
    50                  55                  60                  
Ser Thr Glu Ala Pro Thr Thr Ala Ile Pro Thr Asn Gly Thr Ser Thr
65                  70                  75                  80  
Glu Ala Pro Thr Asp Thr Thr Thr Glu Ala Pro Thr Thr Ala Leu Pro
                85                  90                  95      
Thr Asn Gly Thr Ser Thr Glu Ala Pro Thr Asp Thr Thr Thr Glu Ala
            100                 105                 110         
Pro Thr Thr Gly Leu Pro Thr Asn Gly Thr Thr Ser Ala Phe Pro Pro
        115                 120                 125             
Thr Thr Ser Leu Pro Pro Ser Asn Thr Thr Thr Thr Pro Pro Tyr Asn
    130                 135                 140                 
Pro Ser Thr Asp Tyr Thr Thr Asp Tyr Thr Val Val Thr Glu Tyr Thr
145                 150                 155                 160 
Thr Tyr Cys Pro Glu Pro Thr Thr Phe Thr Thr Asn Gly Lys Thr Tyr
                165                 170                 175     
Thr Val Thr Glu Pro Thr Thr Leu Thr Ile Thr Asp Cys Pro Cys Thr
            180                 185                 190         
Ile Glu Lys Pro Thr Thr Thr Ser Thr Thr Glu Tyr Thr Val Val Thr
        195                 200                 205             
Glu Tyr Thr Thr Tyr Cys Pro Glu Pro Thr Thr Phe Thr Thr Asn Gly
    210                 215                 220                 
Lys Thr Tyr Thr Val Thr Glu Pro Thr Thr Leu Thr Ile Thr Asp Cys
225                 230                 235                 240 
Pro Cys Thr Ile Glu Lys Ser Glu Ala Pro Glu Ser Ser Val Pro Val
                245                 250                 255     
Thr Glu Ser Lys Gly Thr Thr Thr Lys Glu Thr Gly Val Thr Thr Lys
            260                 265                 270         
Gln Thr Thr Ala Asn Pro Ser Leu Thr Val Ser Thr Val Val Pro Val
        275                 280                 285             
Ser Ser Ser Ala Ser Ser His Ser Val Val Ile Asn Ser Asn Gly Ala
    290                 295                 300                 
Asn Val Val Val Pro Gly Ala Leu Gly Leu Ala Gly Val Ala Met Leu
305                 310                 315                 320 
Phe Leu
        


<210> 12
<211> 45
<212> PRT
<213> Artificial Sequence

<220> 
<223> S. cerevisiae SED1 truncated version

<400> 12
Val Asp Leu Thr Val Ser Thr Val Val Pro Val Ser Ser Ser Ala Ser
 1               5                  10                  15      
Ser His Ser Val Val Ile Asn Ser Asn Gly Ala Asn Val Val Val Pro
            20                  25                  30          
Gly Ala Leu Gly Leu Ala Gly Val Ala Met Leu Phe Leu
        35                  40                  45  


<210> 13
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> Pichia pastoris SPI1

<400> 13
Val Asp Leu Val Ser Asn Ser Ser Ser Ser Val Ile Val Val Pro Ser
 1               5                  10                  15      
Ser Asp Ala Thr Ile Ala Gly Asn Asp Thr Ala Thr Pro Ala Pro Glu
            20                  25                  30          
Pro Ser Ser Ala Ala Pro Ile Phe Tyr Asn Ser Thr Ala Thr Ala Thr
        35                  40                  45              
Gln Tyr Glu Val Val Ser Glu Phe Thr Thr Tyr Cys Pro Glu Pro Thr
    50                  55                  60                  
Thr Phe Val Thr Asn Gly Ala Thr Phe Thr Val Thr Ala Pro Thr Thr
65                  70                  75                  80  
Leu Thr Ile Thr Asn Cys Pro Cys Thr Ile Glu Lys Pro Thr Ser Glu
                85                  90                  95      
Thr Ser Val Ser Ser Thr His Asp Val Glu Thr Asn Ser Asn Ala Ala
            100                 105                 110         
Asn Ala Arg Ala Ile Pro Gly Ala Leu Gly Leu Ala Gly Ala Val Met
        115                 120                 125             
Met Leu Leu
    130     


<210> 14
<211> 538
<212> PRT
<213> Artificial Sequence

<220> 
<223> S. cerevisiae GAS1

<400> 14
Val Asp Asp Val Pro Ala Ile Glu Val Val Gly Asn Lys Phe Phe Tyr
 1               5                  10                  15      
Ser Asn Asn Gly Ser Gln Phe Tyr Ile Arg Gly Val Ala Tyr Gln Ala
            20                  25                  30          
Asp Thr Ala Asn Glu Thr Ser Gly Ser Thr Val Asn Asp Pro Leu Ala
        35                  40                  45              
Asn Tyr Glu Ser Cys Ser Arg Asp Ile Pro Tyr Leu Lys Lys Leu Asn
    50                  55                  60                  
Thr Asn Val Ile Arg Val Tyr Ala Ile Asn Thr Thr Leu Asp His Ser
65                  70                  75                  80  
Glu Cys Met Lys Ala Leu Asn Asp Ala Asp Ile Tyr Val Ile Ala Asp
                85                  90                  95      
Leu Ala Ala Pro Ala Thr Ser Ile Asn Arg Asp Asp Pro Thr Trp Thr
            100                 105                 110         
Val Asp Leu Phe Asn Ser Tyr Lys Thr Val Val Asp Thr Phe Ala Asn
        115                 120                 125             
Tyr Thr Asn Val Leu Gly Phe Phe Ala Gly Asn Glu Val Thr Asn Asn
    130                 135                 140                 
Tyr Thr Asn Thr Asp Ala Ser Ala Phe Val Lys Ala Ala Ile Arg Asp
145                 150                 155                 160 
Val Arg Gln Tyr Ile Ser Asp Lys Asn Tyr Arg Lys Ile Pro Val Gly
                165                 170                 175     
Tyr Ser Ser Asn Asp Asp Glu Asp Thr Arg Val Lys Met Thr Asp Tyr
            180                 185                 190         
Phe Ala Cys Gly Asp Asp Asp Val Lys Ala Asp Phe Tyr Gly Ile Asn
        195                 200                 205             
Met Tyr Glu Trp Cys Gly Lys Ser Asp Phe Lys Thr Ser Gly Tyr Ala
    210                 215                 220                 
Asp Arg Thr Ala Glu Phe Lys Asn Leu Ser Ile Pro Val Phe Phe Ser
225                 230                 235                 240 
Glu Tyr Gly Cys Asn Glu Val Thr Pro Arg Leu Phe Thr Glu Val Glu
                245                 250                 255     
Ala Leu Tyr Gly Ser Asn Met Thr Asp Val Trp Ser Gly Gly Ile Val
            260                 265                 270         
Tyr Met Tyr Phe Glu Glu Thr Asn Lys Tyr Gly Leu Val Ser Ile Asp
        275                 280                 285             
Gly Asn Asp Val Lys Thr Leu Asp Asp Phe Asn Asn Tyr Ser Ser Glu
    290                 295                 300                 
Ile Asn Lys Ile Ser Pro Thr Ser Ala Asn Thr Lys Ser Tyr Ser Ala
305                 310                 315                 320 
Thr Thr Ser Asp Val Ala Cys Pro Ala Thr Gly Lys Tyr Trp Ser Ala
                325                 330                 335     
Ala Thr Glu Leu Pro Pro Thr Pro Asn Gly Gly Leu Cys Ser Cys Met
            340                 345                 350         
Asn Ala Ala Asn Ser Cys Val Val Ser Asp Asp Val Asp Ser Asp Asp
        355                 360                 365             
Tyr Glu Thr Leu Phe Asn Trp Ile Cys Asn Glu Val Asp Cys Ser Gly
    370                 375                 380                 
Ile Ser Ala Asn Gly Thr Ala Gly Lys Tyr Gly Ala Tyr Ser Phe Cys
385                 390                 395                 400 
Thr Pro Lys Glu Gln Leu Ser Phe Val Met Asn Leu Tyr Tyr Glu Lys
                405                 410                 415     
Ser Gly Gly Ser Lys Ser Asp Cys Ser Phe Ser Gly Ser Ala Thr Leu
            420                 425                 430         
Gln Thr Ala Thr Thr Gln Ala Ser Cys Ser Ser Ala Leu Lys Glu Ile
        435                 440                 445             
Gly Ser Met Gly Thr Asn Ser Ala Ser Gly Ser Val Asp Leu Gly Ser
    450                 455                 460                 
Gly Thr Glu Ser Ser Thr Ala Ser Ser Asn Ala Ser Gly Ser Ser Ser
465                 470                 475                 480 
Lys Ser Asn Ser Gly Ser Ser Gly Ser Ser Ser Ser Ser Ser Ser Ser
                485                 490                 495     
Ser Ala Ser Ser Ser Ser Ser Ser Lys Lys Asn Ala Ala Thr Asn Val
            500                 505                 510         
Lys Ala Asn Leu Ala Gln Val Val Phe Thr Ser Ile Ile Ser Leu Ser
        515                 520                 525             
Ile Ala Ala Gly Val Gly Phe Ala Leu Val
    530                 535             


<210> 15
<211> 521
<212> PRT
<213> Artificial Sequence

<220> 
<223> Pichia pastoris GAS1

<400> 15
Val Asp Ala Asp Phe Pro Thr Ile Glu Val Thr Gly Asn Lys Phe Phe
 1               5                  10                  15      
Tyr Ser Asn Asn Gly Ser Gln Phe Tyr Ile Lys Gly Val Ala Tyr Gln
            20                  25                  30          
Lys Asp Thr Ser Gly Leu Ser Ser Asp Ala Thr Phe Val Asp Pro Leu
        35                  40                  45              
Ala Asp Lys Ser Thr Cys Glu Arg Asp Ile Pro Tyr Leu Glu Glu Leu
    50                  55                  60                  
Gly Thr Asn Val Ile Arg Val Tyr Ala Val Asp Ala Asp Ala Asp His
65                  70                  75                  80  
Asp Asp Cys Met Gln Met Leu Gln Asp Ala Gly Ile Tyr Val Ile Ala
                85                  90                  95      
Asp Leu Ser Gln Pro Asn Asn Ser Ile Ile Thr Thr Asp Pro Glu Trp
            100                 105                 110         
Thr Val Asp Leu Tyr Asp Gly Tyr Thr Ala Val Leu Asp Asn Leu Gln
        115                 120                 125             
Lys Tyr Asp Asn Ile Leu Gly Phe Phe Ala Gly Asn Glu Val Ile Thr
    130                 135                 140                 
Asn Lys Ser Asn Thr Asp Thr Ala Pro Phe Val Lys Ala Ala Ile Arg
145                 150                 155                 160 
Asp Met Lys Thr Tyr Met Glu Asp Lys Gly Tyr Arg Ser Ile Pro Val
                165                 170                 175     
Gly Tyr Ser Ala Asn Asp Asp Glu Leu Thr Arg Val Ala Ser Ala Asp
            180                 185                 190         
Tyr Phe Ala Cys Gly Asp Ser Asp Val Lys Ala Asp Phe Tyr Gly Ile
        195                 200                 205             
Asn Met Tyr Glu Trp Cys Gly Lys Ala Thr Phe Ser Asn Ser Gly Tyr
    210                 215                 220                 
Lys Asp Arg Thr Ala Glu Phe Lys Asn Leu Ser Ile Pro Val Phe Phe
225                 230                 235                 240 
Ser Glu Tyr Gly Cys Asn Glu Val Gln Pro Arg Leu Phe Thr Glu Val
                245                 250                 255     
Gln Ser Leu Tyr Gly Asp Asp Met Thr Asp Val Trp Ser Gly Gly Ile
            260                 265                 270         
Val Tyr Met Tyr Phe Glu Glu Thr Asn Asn Tyr Gly Leu Val Thr Ile
        275                 280                 285             
Lys Ser Asp Gly Asp Val Ser Thr Leu Glu Asp Phe Asn Asn Leu Lys
    290                 295                 300                 
Thr Glu Leu Ala Ser Ile Ser Pro Ser Ile Ala Thr Gln Ser Glu Val
305                 310                 315                 320 
Ser Ala Thr Ala Thr Glu Ile Asp Cys Pro Ala Thr Gly Ser Asn Trp
                325                 330                 335     
Lys Ala Ser Thr Asp Leu Pro Pro Val Pro Glu Gln Ala Ala Cys Gln
            340                 345                 350         
Cys Met Ala Asp Ala Leu Ser Cys Val Val Ser Glu Asp Val Asp Thr
        355                 360                 365             
Asp Asp Tyr Ser Asp Leu Phe Ser Tyr Val Cys Glu Asn Val Ser Ser
    370                 375                 380                 
Cys Asp Gly Val Ser Ala Asp Ser Glu Ser Gly Glu Tyr Gly Ser Tyr
385                 390                 395                 400 
Ser Phe Cys Ser Ser Lys Glu Lys Leu Ser Phe Leu Leu Asn Leu Tyr
                405                 410                 415     
Tyr Ser Glu Asn Gly Ala Lys Ser Ser Ala Cys Asp Phe Ser Gly Ser
            420                 425                 430         
Ala Thr Leu Val Ser Gly Thr Thr Ala Ser Glu Cys Ser Ser Ile Leu
        435                 440                 445             
Ser Ala Ala Gly Thr Ala Gly Thr Gly Ser Ile Thr Gly Ile Thr Gly
    450                 455                 460                 
Ser Val Glu Ala Ala Thr Gln Ser Gly Ser Asn Ser Gly Ser Ser Lys
465                 470                 475                 480 
Ser Ser Ser Ala Ser Gln Ser Ser Ser Ser Asn Ala Gly Val Gly Gly
                485                 490                 495     
Gly Ala Ser Gly Ser Ser Trp Ala Met Thr Gly Leu Val Ser Ile Ser
            500                 505                 510         
Val Ala Leu Gly Met Ile Met Ser Phe
        515                 520     


<210> 16
<211> 78
<212> PRT
<213> Artificial Sequence

<220> 
<223> Pichia pastoris GAS1 truncated version

<400> 16
Val Asp Ser Ile Leu Ser Ala Ala Gly Thr Ala Gly Thr Gly Ser Ile
 1               5                  10                  15      
Thr Gly Ile Thr Gly Ser Val Glu Ala Ala Thr Gln Ser Gly Ser Asn
            20                  25                  30          
Ser Gly Ser Ser Lys Ser Ser Ser Ala Ser Gln Ser Ser Ser Ser Asn
        35                  40                  45              
Ala Gly Val Gly Gly Gly Ala Ser Gly Ser Ser Trp Ala Met Thr Gly
    50                  55                  60                  
Leu Val Ser Ile Ser Val Ala Leu Gly Met Ile Met Ser Phe
65                  70                  75              


<210> 17
<211> 159
<212> PRT
<213> Artificial Sequence

<220> 
<223> H. polymorpha TIP1

<400> 17
Val Asp Ala Ala Ala Thr Ser Ser Val Ala Ala Ala Ala Ser Glu Val
 1               5                  10                  15      
Ser Ser Ser Ser Ala Ala Ala Ser Ser Thr Gln Ala Ala Ala Ala Ala
            20                  25                  30          
Ser Thr Ser Ala Ala Ala Ser Thr Glu Ala Thr Thr Ser Ala Ala Ala
        35                  40                  45              
Ala Ala Thr Ser Ser Ser Glu Ala Ala Ser Ser Ser Ala His Val His
    50                  55                  60                  
Ser His Ala Ala Glu Ser Thr Ser Ala Val Glu Ser Thr Ser Ala Ala
65                  70                  75                  80  
His Ser His Ala Ala Glu Ser Ser Ser Ala Ala His Ser His Ala Val
                85                  90                  95      
Glu Ser Ser Ser Ala Ala His Val His Ser His Ala Ala Glu Ser Ser
            100                 105                 110         
Ser Ala Ala His Ser His Ala Ala Gly Ser Ser Ser Ala Ala Ser Asn
        115                 120                 125             
Ser Ser Gly His Ile Ser Thr Phe Ser Gly Ala Gly Ala Lys Leu Ala
    130                 135                 140                 
Val Gly Ala Gly Ala Gly Ile Val Gly Leu Ala Ala Leu Leu Met
145                 150                 155                 


<210> 18
<211> 74
<212> PRT
<213> Artificial Sequence

<220> 
<223> H. polymorpha TIP1 truncated version

<400> 18
Val Asp Ser Ser Ala Ala His Ser His Ala Val Glu Ser Ser Ser Ala
 1               5                  10                  15      
Ala His Val His Ser His Ala Ala Glu Ser Ser Ser Ala Ala His Ser
            20                  25                  30          
His Ala Ala Gly Ser Ser Ser Ala Ala Ser Asn Ser Ser Gly His Ile
        35                  40                  45              
Ser Thr Phe Ser Gly Ala Gly Ala Lys Leu Ala Val Gly Ala Gly Ala
    50                  55                  60                  
Gly Ile Val Gly Leu Ala Ala Leu Leu Met
65                  70                  


<210> 19
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human GR2 coiled coil peptide sequence

<400> 19
Thr Ser Arg Leu Glu Gly Leu Gln Ser Glu Asn His Arg Leu Arg Met
 1               5                  10                  15      
Lys Ile Thr Glu Leu Asp Lys Asp Leu Glu Glu Val Thr Met Gln Leu
            20                  25                  30          
Gln Asp Val Gly Gly Cys
        35              


<210> 20
<211> 390
<212> PRT
<213> Artificial Sequence

<220> 
<223> SED 1 Fusion
      Leader GR2 cMyc SED1
      

<400> 20
Met Val Ala Trp Trp Ser Leu Phe Leu Tyr Gly Leu Gln Val Ala Ala
 1               5                  10                  15      
Pro Ala Leu Ala Thr Ser Arg Leu Glu Gly Leu Gln Ser Glu Asn His
            20                  25                  30          
Arg Leu Arg Met Lys Ile Thr Glu Leu Asp Lys Asp Leu Glu Glu Val
        35                  40                  45              
Thr Met Gln Leu Gln Asp Val Gly Gly Cys Glu Gln Lys Leu Ile Ser
    50                  55                  60                  
Glu Glu Asp Leu Val Asp Gln Phe Ser Asn Ser Thr Ser Ala Ser Ser
65                  70                  75                  80  
Thr Asp Val Thr Ser Ser Ser Ser Ile Ser Thr Ser Ser Gly Ser Val
                85                  90                  95      
Thr Ile Thr Ser Ser Glu Ala Pro Glu Ser Asp Asn Gly Thr Ser Thr
            100                 105                 110         
Ala Ala Pro Thr Glu Thr Ser Thr Glu Ala Pro Thr Thr Ala Ile Pro
        115                 120                 125             
Thr Asn Gly Thr Ser Thr Glu Ala Pro Thr Thr Ala Ile Pro Thr Asn
    130                 135                 140                 
Gly Thr Ser Thr Glu Ala Pro Thr Asp Thr Thr Thr Glu Ala Pro Thr
145                 150                 155                 160 
Thr Ala Leu Pro Thr Asn Gly Thr Ser Thr Glu Ala Pro Thr Asp Thr
                165                 170                 175     
Thr Thr Glu Ala Pro Thr Thr Gly Leu Pro Thr Asn Gly Thr Thr Ser
            180                 185                 190         
Ala Phe Pro Pro Thr Thr Ser Leu Pro Pro Ser Asn Thr Thr Thr Thr
        195                 200                 205             
Pro Pro Tyr Asn Pro Ser Thr Asp Tyr Thr Thr Asp Tyr Thr Val Val
    210                 215                 220                 
Thr Glu Tyr Thr Thr Tyr Cys Pro Glu Pro Thr Thr Phe Thr Thr Asn
225                 230                 235                 240 
Gly Lys Thr Tyr Thr Val Thr Glu Pro Thr Thr Leu Thr Ile Thr Asp
                245                 250                 255     
Cys Pro Cys Thr Ile Glu Lys Pro Thr Thr Thr Ser Thr Thr Glu Tyr
            260                 265                 270         
Thr Val Val Thr Glu Tyr Thr Thr Tyr Cys Pro Glu Pro Thr Thr Phe
        275                 280                 285             
Thr Thr Asn Gly Lys Thr Tyr Thr Val Thr Glu Pro Thr Thr Leu Thr
    290                 295                 300                 
Ile Thr Asp Cys Pro Cys Thr Ile Glu Lys Ser Glu Ala Pro Glu Ser
305                 310                 315                 320 
Ser Val Pro Val Thr Glu Ser Lys Gly Thr Thr Thr Lys Glu Thr Gly
                325                 330                 335     
Val Thr Thr Lys Gln Thr Thr Ala Asn Pro Ser Leu Thr Val Ser Thr
            340                 345                 350         
Val Val Pro Val Ser Ser Ser Ala Ser Ser His Ser Val Val Ile Asn
        355                 360                 365             
Ser Asn Gly Ala Asn Val Val Val Pro Gly Ala Leu Gly Leu Ala Gly
    370                 375                 380                 
Val Ala Met Leu Phe Leu
385                 390 


<210> 21
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human GR1 coiled coil peptide sequence
      

<400> 21
Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu Leu Glu Lys
 1               5                  10                  15      
Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu Arg His Gln Leu
            20                  25                  30          
Gln Ser Val Gly Gly Cys
        35              


<210> 22
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb1 (anti-her2) Heavy chain
      

<400> 22
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
        435                 440                 445             
Gly Lys
    450 


<210> 23
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb1 (anti-her2) Light chain

<400> 23
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 24
<211> 438
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb2 (anti-DKK1) Heavy chain

<400> 24
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile His Ser Asn Ser Gly Ala Thr Thr Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Ala Arg Val Thr Met Ser Arg Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Glu Ser Asp Asp Thr Ala Met Tyr Phe Cys
                85                  90                  95      
Ser Arg Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
            100                 105                 110         
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
        115                 120                 125             
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
    130                 135                 140                 
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
145                 150                 155                 160 
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
                165                 170                 175     
Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr
            180                 185                 190         
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
        195                 200                 205             
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
    210                 215                 220                 
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
225                 230                 235                 240 
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                245                 250                 255     
Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
            260                 265                 270         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn
        275                 280                 285             
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    290                 295                 300                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
305                 310                 315                 320 
Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
                325                 330                 335     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
            340                 345                 350         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        355                 360                 365             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    370                 375                 380                 
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
385                 390                 395                 400 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                405                 410                 415     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            420                 425                 430         
Ser Leu Ser Pro Gly Lys
        435             


<210> 25
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb2 (anti-DKK1) Light Chain

<400> 25
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Gly Tyr Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Ala Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80  
Arg Pro Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser
                85                  90                  95      
Leu Ser Ser Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ser
            100                 105                 110         
Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu
        115                 120                 125             
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe
    130                 135                 140                 
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val
145                 150                 155                 160 
Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys
                165                 170                 175     
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser
            180                 185                 190         
His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu
        195                 200                 205             
Lys Thr Val Ala Pro Thr Glu Cys
    210                 215     


<210> 26
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb3 (anti-CD20, C2B8) Heavy chain

<400> 26
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110         
Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445             
Pro Gly Lys
    450     


<210> 27
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb3 (anti-CD20, C2B8) Light chain

<400> 27
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile
            20                  25                  30          
His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
        35                  40                  45              
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             
Asn Arg Gly Glu Cys
    210             


<210> 28
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb4 (anti-CD20, Frame grafted Heavy chain
      

<400> 28
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445             
Pro Gly Lys
    450     


<210> 29
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb4 (anti-CD20, Frame grafted) Light chain
      

<400> 29
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Ala Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             
Asn Arg Gly Glu Cys
    210             


<210> 30
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb5 (anti-CD20, Genmab) Heavy chain

<400> 30
Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                85                  90                  95      
Thr Lys Asp Asn Gln Tyr Gly Ser Gly Ser Thr Tyr Gly Leu Gly Val
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
225                 230                 235                 240 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
        355                 360                 365             
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
        435                 440                 445             
Leu Ser Pro Gly Lys
    450             


<210> 31
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb5 (anti-CD20, Genmab) Light chain

<400> 31
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 32
<211> 514
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-Her2 mAb heavy chain readthrough coiled coil
      peptide with one stop codon
      

<220> 
<223> Xaa=unkown amino acid inserted by stop codon
      readthrough

<220> 
<221> DOMAIN         
<222> (475)...(514)
<223> GR1 coiled coil

<400> 32
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
        435                 440                 445             
Gly Lys Xaa Ala Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly
    450                 455                 460                 
Gly His His His His His His His His His Gly Gly Glu Glu Lys Ser
465                 470                 475                 480 
Arg Leu Leu Glu Lys Glu Asn Arg Glu Leu Glu Lys Ile Ile Ala Glu
                485                 490                 495     
Lys Glu Glu Arg Val Ser Glu Leu Arg His Gln Leu Gln Ser Val Gly
            500                 505                 510         
Gly Cys
        


<210> 33
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> Alpha amylase signal sequence (from Aspergillus
      niger  -amylase) (DNA)

<400> 33
atggttgctt ggtggtcctt gttcttgtac ggattgcaag ttgctgctcc agctttggct 60


<210> 34
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Alpha amylase signal sequence (from Aspergillus
      niger  -amylase) (DNA)

<400> 34
Met Val Ala Trp Trp Ser Leu Phe Leu Tyr Gly Leu Gln Val Ala Ala
 1               5                  10                  15      
Pro Ala Leu Ala
            20  


<210> 35
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer hPDI/UP1

<400> 35
agcgctgacg cccccgagga ggaggaccac                                  30

<210> 36
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer hPDI/LP-PacI

<400> 36
ccttaattaa ttacagttca tcatgcacag ctttctgatc at                    42

<210> 37
<211> 1476
<212> DNA
<213> Artificial Sequence

<220> 
<223> DNA encoding relevant portion of human PDI

<400> 37
gacgcccccg aggaggagga ccacgtcttg gtgctgcgga aaagcaactt cgcggaggcg 60
ctggcggccc acaagtaccc gccggtggag ttccatgccc cctggtgtgg ccactgcaag 120
gctctggccc ctgagtatgc caaagccgct gggaagctga aggcagaagg ttccgagatc 180
aggttggcca aggtggacgc cacggaggag tctgacctag cccagcagta cggcgtgcgc 240
ggctatccca ccatcaagtt cttcaggaat ggagacacgg cttcccccaa ggaatataca 300
gctggcagag aggctgatga catcgtgaac tggctgaaga agcgcacggg cccggctgcc 360
accaccctgc ctgacggcgc agctgcagag tccttggtgg agtccagcga ggtggccgtc 420
atcggcttct tcaaggacgt ggagtcggac tctgccaagc agtttttgca ggcagcagag 480
gccatcgatg acataccatt tgggatcact tccaacagtg acgtgttctc caaataccag 540
ctcgacaaag atggggttgt cctctttaag aagtttgatg aaggccggaa caactttgaa 600
ggggaggtca ccaaggagaa cctgctggac tttatcaaac acaaccagct gccccttgtc 660
atcgagttca ccgagcagac agccccgaag atttttggag gtgaaatcaa gactcacatc 720
ctgctgttct tgcccaagag tgtgtctgac tatgacggca aactgagcaa cttcaaaaca 780
gcagccgaga gcttcaaggg caagatcctg ttcatcttca tcgacagcga ccacaccgac 840
aaccagcgca tcctcgagtt ctttggcctg aagaaggaag agtgcccggc cgtgcgcctc 900
atcaccttgg aggaggagat gaccaagtac aagcccgaat cggaggagct gacggcagag 960
aggatcacag agttctgcca ccgcttcctg gagggcaaaa tcaagcccca cctgatgagc 1020
caggagctgc cggaggactg ggacaagcag cctgtcaagg tgcttgttgg gaagaacttt 1080
gaagacgtgg cttttgatga gaaaaaaaac gtctttgtgg agttctatgc cccatggtgt 1140
ggtcactgca aacagttggc tcccatttgg gataaactgg gagagacgta caaggaccat 1200
gagaacatcg tcatcgccaa gatggactcg actgccaacg aggtggaggc cgtcaaagtg 1260
cacggcttcc ccacactcgg gttctttcct gccagtgccg acaggacggt cattgattac 1320
aacggggaac gcacgctgga tggttttaag aaattcctag agagcggtgg ccaagatggg 1380
gcaggggatg ttgacgacct cgaggacctc gaagaagcag aggagccaga catggaggaa 1440
gacgatgacc agaaagctgt gaaagatgaa ctgtaa                           1476

<210> 38
<211> 491
<212> PRT
<213> Artificial Sequence

<220> 
<223> Relevant portion of human PDI

<400> 38
Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser Asn
 1               5                  10                  15      
Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Pro Pro Val Glu Phe His
            20                  25                  30          
Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala Lys
        35                  40                  45              
Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala Lys
    50                  55                  60                  
Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val Arg
65                  70                  75                  80  
Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser Pro
                85                  90                  95      
Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp Leu
            100                 105                 110         
Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala Ala
        115                 120                 125             
Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe Phe
    130                 135                 140                 
Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala Glu
145                 150                 155                 160 
Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val Phe
                165                 170                 175     
Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys Phe
            180                 185                 190         
Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn Leu
        195                 200                 205             
Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe Thr
    210                 215                 220                 
Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His Ile
225                 230                 235                 240 
Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu Ser
                245                 250                 255     
Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe Ile
            260                 265                 270         
Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe Phe
        275                 280                 285             
Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu Glu
    290                 295                 300                 
Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala Glu
305                 310                 315                 320 
Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys Pro
                325                 330                 335     
His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro Val
            340                 345                 350         
Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu Lys
        355                 360                 365             
Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys
    370                 375                 380                 
Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp His
385                 390                 395                 400 
Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val Glu
                405                 410                 415     
Ala Val Lys Val His Gly Phe Pro Thr Leu Gly Phe Phe Pro Ala Ser
            420                 425                 430         
Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp Gly
        435                 440                 445             
Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp Val
    450                 455                 460                 
Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu Glu
465                 470                 475                 480 
Asp Asp Asp Gln Lys Ala Val His Asp Glu Leu
                485                 490     


<210> 39
<211> 1554
<212> DNA
<213> Pichia pastoris

<400> 39
atgcaattca actggaatat taaaactgtg gcaagtattt tgtccgctct cacactagca 60
caagcaagtg atcaggaggc tattgctcca gaggactctc atgtcgtcaa attgactgaa 120
gccacttttg agtctttcat caccagtaat cctcacgttt tggcagagtt ttttgcccct 180
tggtgtggtc actgtaagaa gttgggccct gaacttgttt ctgctgccga gatcttaaag 240
gacaatgagc aggttaagat tgctcaaatt gattgtacgg aggagaagga attatgtcaa 300
ggctacgaaa ttaaagggta tcctactttg aaggtgttcc atggtgaggt tgaggtccca 360
agtgactatc aaggtcaaag acagagccaa agcattgtca gctatatgct aaagcagagt 420
ttaccccctg tcagtgaaat caatgcaacc aaagatttag acgacacaat cgccgaggca 480
aaagagcccg tgattgtgca agtactaccg gaagatgcat ccaacttgga atctaacacc 540
acattttacg gagttgccgg tactctcaga gagaaattca cttttgtctc cactaagtct 600
actgattatg ccaaaaaata cactagcgac tcgactcctg cctatttgct tgtcagacct 660
ggcgaggaac ctagtgttta ctctggtgag gagttagatg agactcattt ggtgcactgg 720
attgatattg agtccaaacc tctatttgga gacattgacg gatccacctt caaatcatat 780
gctgaagcta acatcccttt agcctactat ttctatgaga acgaagaaca acgtgctgct 840
gctgccgata ttattaaacc ttttgctaaa gagcaacgtg gcaaaattaa ctttgttggc 900
ttagatgccg ttaaattcgg taagcatgcc aagaacttaa acatggatga agagaaactc 960
cctctatttg tcattcatga tttggtgagc aacaagaagt ttggagttcc tcaagaccaa 1020
gaattgacga acaaagatgt gaccgagctg attgagaaat tcatcgcagg agaggcagaa 1080
ccaattgtga aatcagagcc aattccagaa attcaagaag agaaagtctt caagctagtc 1140
ggaaaggccc acgatgaagt tgtcttcgat gaatctaaag atgttctagt caagtactac 1200
gccccttggt gtggtcactg taagagaatg gctcctgctt atgaggaatt ggctactctt 1260
tacgccaatg atgaggatgc ctcttcaaag gttgtgattg caaaacttga tcacactttg 1320
aacgatgtcg acaacgttga tattcaaggt tatcctactt tgatccttta tccagctggt 1380
gataaatcca atcctcaact gtatgatgga tctcgtgacc tagaatcatt ggctgagttt 1440
gtaaaggaga gaggaaccca caaagtggat gccctagcac tcagaccagt cgaggaagaa 1500
aaggaagctg aagaagaagc tgaaagtgag gcagacgctc acgacgagct ttaa       1554

<210> 40
<211> 517
<212> PRT
<213> Pichia pastoris

<400> 40
Met Gln Phe Asn Trp Asn Ile Lys Thr Val Ala Ser Ile Leu Ser Ala
 1               5                  10                  15      
Leu Thr Leu Ala Gln Ala Ser Asp Gln Glu Ala Ile Ala Pro Glu Asp
            20                  25                  30          
Ser His Val Val Lys Leu Thr Glu Ala Thr Phe Glu Ser Phe Ile Thr
        35                  40                  45              
Ser Asn Pro His Val Leu Ala Glu Phe Phe Ala Pro Trp Cys Gly His
    50                  55                  60                  
Cys Lys Lys Leu Gly Pro Glu Leu Val Ser Ala Ala Glu Ile Leu Lys
65                  70                  75                  80  
Asp Asn Glu Gln Val Lys Ile Ala Gln Ile Asp Cys Thr Glu Glu Lys
                85                  90                  95      
Glu Leu Cys Gln Gly Tyr Glu Ile Lys Gly Tyr Pro Thr Leu Lys Val
            100                 105                 110         
Phe His Gly Glu Val Glu Val Pro Ser Asp Tyr Gln Gly Gln Arg Gln
        115                 120                 125             
Ser Gln Ser Ile Val Ser Tyr Met Leu Lys Gln Ser Leu Pro Pro Val
    130                 135                 140                 
Ser Glu Ile Asn Ala Thr Lys Asp Leu Asp Asp Thr Ile Ala Glu Ala
145                 150                 155                 160 
Lys Glu Pro Val Ile Val Gln Val Leu Pro Glu Asp Ala Ser Asn Leu
                165                 170                 175     
Glu Ser Asn Thr Thr Phe Tyr Gly Val Ala Gly Thr Leu Arg Glu Lys
            180                 185                 190         
Phe Thr Phe Val Ser Thr Lys Ser Thr Asp Tyr Ala Lys Lys Tyr Thr
        195                 200                 205             
Ser Asp Ser Thr Pro Ala Tyr Leu Leu Val Arg Pro Gly Glu Glu Pro
    210                 215                 220                 
Ser Val Tyr Ser Gly Glu Glu Leu Asp Glu Thr His Leu Val His Trp
225                 230                 235                 240 
Ile Asp Ile Glu Ser Lys Pro Leu Phe Gly Asp Ile Asp Gly Ser Thr
                245                 250                 255     
Phe Lys Ser Tyr Ala Glu Ala Asn Ile Pro Leu Ala Tyr Tyr Phe Tyr
            260                 265                 270         
Glu Asn Glu Glu Gln Arg Ala Ala Ala Ala Asp Ile Ile Lys Pro Phe
        275                 280                 285             
Ala Lys Glu Gln Arg Gly Lys Ile Asn Phe Val Gly Leu Asp Ala Val
    290                 295                 300                 
Lys Phe Gly Lys His Ala Lys Asn Leu Asn Met Asp Glu Glu Lys Leu
305                 310                 315                 320 
Pro Leu Phe Val Ile His Asp Leu Val Ser Asn Lys Lys Phe Gly Val
                325                 330                 335     
Pro Gln Asp Gln Glu Leu Thr Asn Lys Asp Val Thr Glu Leu Ile Glu
            340                 345                 350         
Lys Phe Ile Ala Gly Glu Ala Glu Pro Ile Val Lys Ser Glu Pro Ile
        355                 360                 365             
Pro Glu Ile Gln Glu Glu Lys Val Phe Lys Leu Val Gly Lys Ala His
    370                 375                 380                 
Asp Glu Val Val Phe Asp Glu Ser Lys Asp Val Leu Val Lys Tyr Tyr
385                 390                 395                 400 
Ala Pro Trp Cys Gly His Cys Lys Arg Met Ala Pro Ala Tyr Glu Glu
                405                 410                 415     
Leu Ala Thr Leu Tyr Ala Asn Asp Glu Asp Ala Ser Ser Lys Val Val
            420                 425                 430         
Ile Ala Lys Leu Asp His Thr Leu Asn Asp Val Asp Asn Val Asp Ile
        435                 440                 445             
Gln Gly Tyr Pro Thr Leu Ile Leu Tyr Pro Ala Gly Asp Lys Ser Asn
    450                 455                 460                 
Pro Gln Leu Tyr Asp Gly Ser Arg Asp Leu Glu Ser Leu Ala Glu Phe
465                 470                 475                 480 
Val Lys Glu Arg Gly Thr His Lys Val Asp Ala Leu Ala Leu Arg Pro
                485                 490                 495     
Val Glu Glu Glu Lys Glu Ala Glu Glu Glu Ala Glu Ser Glu Ala Asp
            500                 505                 510         
Ala His Asp Glu Leu
        515         


<210> 41
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer PB248

<400> 41
atgaattcag gccatatcgg ccattgttta ctgtgcgccc acagtag               47

<210> 42
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer PB249

<400> 42
atgtttaaac gtgaggatta ctggtgatga aagac                            35

<210> 43
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer PB250

<400> 43
agactagtct atttggagac attgacggat ccac                             34

<210> 44
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer PB251

<400> 44
atctcgagag gccatgcagg ccaaccacaa gatgaatcaa attttg                46

<210> 45
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer hGRP94/UP1

<400> 45
agcgctgacg atgaagttga tgtggatggt acagtag                          37

<210> 46
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer hGRP94/LP1

<400> 46
ggccggcctt acaattcatc atgttcagct gtagattc                         38

<210> 47
<211> 2349
<212> DNA
<213> Artificial Sequence

<220> 
<223> Encodes relevant portion of GRP94

<400> 47
gatgatgaag ttgacgttga cggtactgtt gaagaggact tgggaaagtc tagagagggt 60
tccagaactg acgacgaagt tgttcagaga gaggaagagg ctattcagtt ggacggattg 120
aacgcttccc aaatcagaga gttgagagag aagtccgaga agttcgcttt ccaagctgag 180
gttaacagaa tgatgaaatt gattatcaac tccttgtaca agaacaaaga gattttcttg 240
agagagttga tctctaacgc ttctgacgct ttggacaaga tcagattgat ctccttgact 300
gacgaaaacg ctttgtccgg taacgaagag ttgactgtta agatcaagtg tgacaaagag 360
aagaacttgt tgcacgttac tgacactggt gttggaatga ctagagaaga gttggttaag 420
aacttgggta ctatcgctaa gtctggtact tccgagttct tgaacaagat gactgaggct 480
caagaagatg gtcaatccac ttccgagttg attggtcagt tcggtgttgg tttctactcc 540
gctttcttgg ttgctgacaa ggttatcgtt acttccaagc acaacaacga cactcaacac 600
atttgggaat ccgattccaa cgagttctcc gttattgctg acccaagagg taacactttg 660
ggtagaggta ctactatcac tttggttttg aaagaagagg cttccgacta cttggagttg 720
gacactatca agaacttggt taagaagtac tcccagttca tcaacttccc aatctatgtt 780
tggtcctcca agactgagac tgttgaggaa ccaatggaag aagaagaggc tgctaaagaa 840
gagaaagagg aatctgacga cgaggctgct gttgaagaag aggaagaaga aaagaagcca 900
aagactaaga aggttgaaaa gactgtttgg gactgggagc ttatgaacga catcaagcca 960
atttggcaga gaccatccaa agaggttgag gaggacgagt acaaggcttt ctacaagtcc 1020
ttctccaaag aatccgatga cccaatggct tacatccact tcactgctga gggtgaagtt 1080
actttcaagt ccatcttgtt cgttccaact tctgctccaa gaggattgtt cgacgagtac 1140
ggttctaaga agtccgacta catcaaactt tatgttagaa gagttttcat cactgacgac 1200
ttccacgata tgatgccaaa gtacttgaac ttcgttaagg gtgttgttga ttccgatgac 1260
ttgccattga acgtttccag agagactttg cagcagcaca agttgttgaa ggttatcaga 1320
aagaaacttg ttagaaagac tttggacatg atcaagaaga tcgctgacga caagtacaac 1380
gacactttct ggaaagagtt cggaactaac atcaagttgg gtgttattga ggaccactcc 1440
aacagaacta gattggctaa gttgttgaga ttccagtcct ctcatcaccc aactgacatc 1500
acttccttgg accagtacgt tgagagaatg aaagagaagc aggacaaaat ctacttcatg 1560
gctggttcct ctagaaaaga ggctgaatcc tccccattcg ttgagagatt gttgaagaag 1620
ggttacgagg ttatctactt gactgagcca gttgacgagt actgtatcca ggctttgcca 1680
gagtttgacg gaaagagatt ccagaacgtt gctaaagagg gtgttaagtt cgacgaatcc 1740
gaaaagacta aagaatccag agaggctgtt gagaaagagt tcgagccatt gttgaactgg 1800
atgaaggaca aggctttgaa ggacaagatc gagaaggctg ttgtttccca gagattgact 1860
gaatccccat gtgctttggt tgcttcccaa tacggatgga gtggtaacat ggaaagaatc 1920
atgaaggctc aggcttacca aactggaaag gacatctcca ctaactacta cgcttcccag 1980
aagaaaactt tcgagatcaa cccaagacac ccattgatca gagacatgtt gagaagaatc 2040
aaagaggacg aggacgacaa gactgttttg gatttggctg ttgttttgtt cgagactgct 2100
actttgagat ccggttactt gttgccagac actaaggctt acggtgacag aatcgagaga 2160
atgttgagat tgtccttgaa cattgaccca gacgctaagg ttgaagaaga accagaagaa 2220
gagccagagg aaactgctga agatactact gaggacactg aacaagacga ggacgaagag 2280
atggatgttg gtactgacga agaggaagag acagcaaagg aatccactgc tgaacacgac 2340
gagttgtaa                                                         2349

<210> 48
<211> 782
<212> PRT
<213> Artificial Sequence

<220> 
<223> Relevant portion of GPR94

<400> 48
Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu Glu Asp Leu Gly Lys
 1               5                  10                  15      
Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val Val Gln Arg Glu Glu
            20                  25                  30          
Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser Gln Ile Arg Glu Leu
        35                  40                  45              
Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala Glu Val Asn Arg Met
    50                  55                  60                  
Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn Lys Glu Ile Phe Leu
65                  70                  75                  80  
Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu Asp Lys Ile Arg Leu
                85                  90                  95      
Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly Asn Glu Glu Leu Thr
            100                 105                 110         
Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu Leu His Val Thr Asp
        115                 120                 125             
Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val Lys Asn Leu Gly Thr
    130                 135                 140                 
Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn Lys Met Thr Glu Ala
145                 150                 155                 160 
Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile Gly Gln Phe Gly Val
                165                 170                 175     
Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys Val Ile Val Thr Ser
            180                 185                 190         
Lys His Asn Asn Asp Thr Gln His Ile Trp Glu Ser Asp Ser Asn Glu
        195                 200                 205             
Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr Leu Gly Arg Gly Thr
    210                 215                 220                 
Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser Asp Tyr Leu Glu Leu
225                 230                 235                 240 
Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser Gln Phe Ile Asn Phe
                245                 250                 255     
Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr Val Glu Glu Pro Met
            260                 265                 270         
Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu Glu Ser Asp Asp Glu
        275                 280                 285             
Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys Pro Lys Thr Lys Lys
    290                 295                 300                 
Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met Asn Asp Ile Lys Pro
305                 310                 315                 320 
Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu Asp Glu Tyr Lys Ala
                325                 330                 335     
Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp Pro Met Ala Tyr Ile
            340                 345                 350         
His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys Ser Ile Leu Phe Val
        355                 360                 365             
Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu Tyr Gly Ser Lys Lys
    370                 375                 380                 
Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Thr Asp Asp
385                 390                 395                 400 
Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe Val Lys Gly Val Val
                405                 410                 415     
Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg Glu Thr Leu Gln Gln
            420                 425                 430         
His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu Val Arg Lys Thr Leu
        435                 440                 445             
Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr Asn Asp Thr Phe Trp
    450                 455                 460                 
Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val Ile Glu Asp His Ser
465                 470                 475                 480 
Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe Gln Ser Ser His His
                485                 490                 495     
Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val Glu Arg Met Lys Glu
            500                 505                 510         
Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser Ser Arg Lys Glu Ala
        515                 520                 525             
Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys Lys Gly Tyr Glu Val
    530                 535                 540                 
Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys Ile Gln Ala Leu Pro
545                 550                 555                 560 
Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala Lys Glu Gly Val Lys
                565                 570                 575     
Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg Glu Ala Val Glu Lys
            580                 585                 590         
Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp Lys Ala Leu Lys Asp
        595                 600                 605             
Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu Thr Glu Ser Pro Cys
    610                 615                 620                 
Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile
625                 630                 635                 640 
Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr
                645                 650                 655     
Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn Pro Arg His Pro Leu
            660                 665                 670         
Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp Glu Asp Asp Lys Thr
        675                 680                 685             
Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr Ala Thr Leu Arg Ser
    690                 695                 700                 
Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly Asp Arg Ile Glu Arg
705                 710                 715                 720 
Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp Ala Lys Val Glu Glu
                725                 730                 735     
Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu Asp Thr Thr Glu Asp
            740                 745                 750         
Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val Gly Thr Asp Glu Glu
        755                 760                 765             
Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu His Asp Glu Leu
    770                 775                 780         


<210> 49
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> Saccharomyces cerevisiae mating factor pre-signal
      peptide

<400> 49
atgagattcc catccatctt cactgctgtt ttgttcgctg cttcttctgc tttggct    57

<210> 50
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Saccharomyces cerevisiae mating factor pre-signal
      peptide

<400> 50
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser
 1               5                  10                  15      
Ala Leu Ala
            


<210> 51
<211> 966
<212> DNA
<213> Artificial Sequence

<220> 
<223> Fab Anti-Her2 HC-GR1 fusion with Pre-pro alpha-
      mating factor signal peptide (ScalphaMTprepro)

<220> 
<221> sig_peptide    
<222> (1)...(57)
<223>  Pre-pro alpha- mating factor signal peptide

<220> 
<221> misc_feature   
<222> (847)...(966)
<223> GR1 coiled coil

<400> 51
atgagattcc catccatctt cactgctgtt ttgttcgctg cttcttctgc tttggctgag 60
gttcagttgg ttgaatctgg aggaggattg gttcaacctg gtggttcttt gagattgtcc 120
tgtgctgctt ccggtttcaa catcaaggac acttacatcc actgggttag acaagctcca 180
ggaaagggat tggagtgggt tgctagaatc tacccaacta acggttacac aagatacgct 240
gactccgtta agggaagatt cactatctct gctgacactt ccaagaacac tgcttacttg 300
cagatgaact ccttgagagc tgaggatact gctgtttact actgttccag atggggtggt 360
gatggtttct acgctatgga ctactggggt caaggaactt tggttactgt ttcctccgct 420
tctactaagg gaccatctgt tttcccattg gctccatctt ctaagtctac ttccggtggt 480
actgctgctt tgggatgttt ggttaaagac tacttcccag agccagttac tgtttcttgg 540
aactccggtg ctttgacttc tggtgttcac actttcccag ctgttttgca atcttccggt 600
ttgtactctt tgtcctccgt tgttactgtt ccatcctctt ccttgggtac tcagacttac 660
atctgtaacg ttaaccacaa gccatccaac actaaggttg acaagaaggt tgagccaaag 720
tcctgtggtg gtggtggtag tggaggtggt ggaagtggtg gcggtggttc tgcggccgct 780
tatccatatg atgttccaga ctacgctgga ggtcatcatc atcaccacca tcaccatcat 840
ggtggtgaag agaagtccag attgttggag aaagagaaca gagagttgga gaagatcatc 900
gctgagaaag aagagagagt ttccgagttg agacaccaat tgcaatccgt tggtggttgt 960
taatag                                                            966

<210> 52
<211> 705
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-Her2 LC with Pre-pro alpha- mating factor
      signal peptide (ScalphaMTprepro)

<220> 
<221> sig_peptide    
<222> (1)...(57)
<223> Pre-pro alpha- mating factor signal peptide

<400> 52
atgagattcc catccatctt cactgctgtt ttgttcgctg cttcttctgc tttggctgac 60
atccaaatga ctcaatcccc atcttctttg tctgcttccg ttggtgacag agttactatc 120
acttgtagag cttcccagga cgttaatact gctgttgctt ggtatcaaca gaagccagga 180
aaggctccaa agttgttgat ctactccgct tccttcttgt actctggtgt tccatccaga 240
ttctctggtt ccagatccgg tactgacttc actttgacta tctcctcctt gcaaccagaa 300
gatttcgcta cttactactg tcagcagcac tacactactc caccaacttt cggacagggt 360
actaaggttg agatcaagag aactgttgct gctccatccg ttttcatttt cccaccatcc 420
gacgaacagt tgaagtctgg tacagcttcc gttgtttgtt tgttgaacaa cttctaccca 480
agagaggcta aggttcagtg gaaggttgac aacgctttgc aatccggtaa ctcccaagaa 540
tccgttactg agcaagactc taaggactcc acttactcct tgtcctccac tttgactttg 600
tccaaggctg attacgagaa gcacaaggtt tacgcttgtg aggttacaca tcagggtttg 660
tcctccccag ttactaagtc cttcaacaga ggagagtgtt aatag                 705

<210> 53
<211> 943
<212> DNA
<213> Artificial Sequence

<220> 
<223> Fab Anti-DKK1 HC-GR1 fusion with Alpha amylase
      signal peptide (from Aspergillus niger
      alpha-amylase)

<220> 
<221> sig_peptide    
<222> (1)...(60)
<223> Alpha amylase signal peptide

<220> 
<221> misc_feature   
<222> (823)...(943)
<223> GR coiled coil

<400> 53
atggtcgctt ggtggtcttt gtttctgtac ggtcttcagg tcgctgcacc tgctttggct 60
gaggttcagt tggttcaatc tggtgctgag gttaagaaac ctggtgcttc cgttaaggtt 120
tcctgtaagg cttccggtta cactttcact gactactaca tccactgggt tagacaagct 180
ccaggtcaag gattggaatg gatgggatgg attcactcta actccggtgc tactacttac 240
gctcagaagt tccaggctag agttactatg tccagagaca cttcttcttc cactgcttac 300
atggaattgt ccagattgga atccgatgac actgctatgt acttttgttc cagagaggac 360
tactggggac agggaacttt ggttactgtt tcctccgctt ctactaaagg gccctctgtt 420
tttccattgg ctccatgttc tagatccact tccgaatcca ctgctgcttt gggatgtttg 480
gttaaggact acttcccaga gccagttact gtttcttgga actccggtgc tttgacttct 540
ggtgttcaca ctttcccagc tgttttgcaa tcttccggtt tgtactcctt gtcctccgtt 600
gttactgtta cttcctccaa cttcggtact cagacttaca cttgtaacgt tgaccacaag 660
ccatccaaca ctaaggttga caagactgtt gagagaaagt gtggtggtgg tggtagtgga 720
ggtggtggaa gtggtggcgg tggttctgcg gccgcttatc catatgatgt tccagactac 780
gctggaggtc atcatcatca ccaccatcac catcatggtg gtgaagagaa gtccagattg 840
ttggagaaag agaacagaga gttggagaag atcatcgctg agaaagaaga gagagtttcc 900
gagttgagac accaattgca atccgttggt ggttgttaat agg                   943

<210> 54
<211> 718
<212> DNA
<213> Artificial Sequence

<220> 
<223> Fab Anti-DKK1 LC with Alpha amylase signal peptide
      (from Aspergillus niger alpha -amylase)

<220> 
<221> sig_peptide    
<222> (1)...(60)
<223> Alpha-amylase signal peptide

<400> 54
atggtcgctt ggtggtcttt gtttctgtac ggtcttcagg tcgctgcacc tgctttggct 60
cagtccgttt tgacacaacc accatctgtt tctggtgctc caggacagag agttactatc 120
tcctgtactg gttcctcttc caacattggt gctggttacg atgttcactg gtatcaacag 180
ttgccaggta ctgctccaaa gttgttgatc tacggttact ccaacagacc atctggtgtt 240
ccagacagat tctctggttc taagtctggt gcttctgctt ccttggctat cactggattg 300
agaccagatg acgaggctga ctactactgt caatcctacg acaactcctt gtcctcttac 360
gttttcggtg gtggtactca gttgactgtt ttgtcccagc caaaggctaa tccaactgtt 420
actttgttcc caccatcttc cgaagaactg caggctaata aggctacttt ggtttgtttg 480
atctccgact tctacccagg tgctgttact gttgcttgga aggctgatgg ttctccagtt 540
aaggctggtg ttgagactac taagccatcc aagcagtcca ataacaagta cgctgctagc 600
tcttacttgt ccttgacacc agaacaatgg aagtcccaca gatcctactc ttgtcaggtt 660
acacacgagg gttctactgt tgaaaagact gttgctccaa ctgagtgttc ctaatgag   718

<210> 55
<211> 972
<212> DNA
<213> Artificial Sequence

<220> 
<223> Fab Anti-CD20, C2B8 HC with Alpha amylase signal
      peptide (from Aspergillus niger alpha -amylase)

<220> 
<221> sig_peptide    
<222> (1)...(60)
<223> Alpha amylase signal peptide

<220> 
<221> misc_feature   
<222> (876)...(972)
<223> GR1 coiled coil

<400> 55
atggttgctt ggtggtcttt gttcttgtac ggattgcaag ttgctgctcc agctttggct 60
caagttcagc tgcaacaacc aggtgctgaa ttggttaagc ctggtgcttc tgttaagatg 120
tcttgtaagg cttctggtta cactttcact tcctacaaca tgcactgggt taagcaaact 180
ccaggtagag gattggaatg gattggtgct atctacccag gtaacggtga cacttcttat 240
aaccaaaagt tcaagggaaa ggctactttg actgctgaca aatcttcttc tactgcttac 300
atgcaattgt cctccttgac ttctgaagat tctgctgttt actactgtgc tagatccact 360
tactacggtg gtgactggta ctttaatgtt tggggtgctg gtactactgt tactgtctcg 420
agtgcttcta ctaagggacc atctgttttc ccattggctc catcttctaa gtctacttcc 480
ggtggtaccg ctgctttggg atgtttggtt aaagactact tcccagagcc agttactgtt 540
tcttggaact ccggtgcttt gacttctggt gttcacactt tcccagctgt tttgcaatct 600
tccggtttgt actctttgtc ctccgttgtt actgttccat cctcttcctt gggtactcag 660
acttacatct gtaacgttaa ccacaagcca tccaacacta aggttgacaa gaaggttgag 720
ccaaagtcct gtggtggtgg tggtagtgga ggtggtggaa gtggtggcgg tggttctgcg 780
gccgcttatc catatgatgt tccagactac gctggaggtc atcatcatca ccaccatcac 840
catcatggtg gtgaagagaa gtccagattg ttggagaaag agaacagaga gttggagaag 900
atcatcgctg agaaagaaga gagagtttcc gagttgagac accaattgca atccgttggt 960
ggttgttaat ag                                                     972

<210> 56
<211> 702
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-CD20, C28B LC  with Alpha amylase signal
      peptide (from Aspergillus niger alpha -amylase)

<220> 
<221> sig_peptide    
<222> (1)...(60)
<223> Alpha amylase signal peptide

<400> 56
atggttgctt ggtggtcctt gttcttgtac ggattgcaag ttgctgctcc agctttggct 60
gagatcgttt tgacacagtc cccagctact ttgtctttgt ccccaggtga aagagctaca 120
ttgtcctgta gagcttcctc ttccgtttcc tacatccact ggtatcaaca aaagccagga 180
caggctccaa gattgttgat ctacgctact tccaacttgg cttccggtat tccagctaga 240
ttctctggtt ctggttccgg tactgacttc actttgacta tctcttcctt ggaaccagag 300
gacttcgctg tttactactg tcaacagtgg acttctaacc caccaacttt cggacaaggt 360
actaaggttg agatcaagcg tacggttgct gctccttccg ttttcatttt cccaccatcc 420
gacgaacaat tgaagtctgg taccgcttcc gttgtttgtt tgttgaacaa cttctaccca 480
cgtgaggcta aggttcagtg gaaggttgac aacgctttgc aatccggtaa ctcccaagaa 540
tccgttactg agcaggattc taaggattcc acttactcat tgtcctccac tttgactttg 600
tccaaggctg attacgagaa gcacaaggtt tacgcatgcg aggttacaca tcagggtttg 660
tcctccccag ttactaagtc cttcaacaga ggagagtgtt aa                    702

<210> 57
<211> 972
<212> DNA
<213> Artificial Sequence

<220> 
<223> Fab Anti-CD20 frame grafted HC-GR1  with Alpha
      amylase signal peptide (from Aspergillus niger
      alpha -amylase)

<220> 
<221> sig_peptide    
<222> (1)...(60)
<223> Alpha amylase signal peptide

<220> 
<221> misc_feature   
<222> (853)...(972)
<223> GR1 coiled coil

<400> 57
atggttgctt ggtggtcctt gttcttgtac ggattgcaag ttgctgctcc agctttggct 60
caagttcagc tggttcaatc tggtgctgag gttaagaagc ctggttcctc cgttaaggtt 120
tcctgtaagg cttccggtta cactttcact tcctacaaca tgcactgggt tagacaagct 180
ccaggtcaag gattggaatg gatgggtgct atctacccag gtaacggtga cacttcttac 240
aaccagaagt tcaagggtag agttactatc actgctgacg aatccacttc cactgcttac 300
atggaattgt cctcattgag atccgaggac actgctgttt actactgtgc tagatccact 360
tactacggtg gtgactggta ctttaatgtt tggggacagg gaactttggt tactgtctcg 420
agtgcttcta ctaagggacc atccgttttt ccattggctc catcctctaa gtctacttcc 480
ggtggtaccg ctgctttggg atgtttggtt aaagactact tcccagagcc agttactgtt 540
tcttggaact ccggtgcttt gacttctggt gttcacactt tcccagctgt tttgcaatct 600
tccggtttgt actctttgtc ctccgttgtt actgttccat cctcttcctt gggtactcag 660
acttacatct gtaacgttaa ccacaagcca tccaacacta aggttgacaa gaaggttgag 720
ccaaagtcct gtggtggtgg tggtagtgga ggtggtggaa gtggtggcgg tggttctgcg 780
gccgcttatc catatgatgt tccagactac gctggaggtc atcatcatca ccaccatcac 840
catcatggtg gtgaagagaa gtccagattg ttggagaaag agaacagaga gttggagaag 900
atcatcgctg agaaagaaga gagagtttcc gagttgagac accaattgca atccgttggt 960
ggttgttaat ag                                                     972

<210> 58
<211> 702
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-CD20 frame grafted LC   with Alpha amylase
      signal peptide (from Aspergillus niger alpha
      -amylase)

<220> 
<221> sig_peptide    
<222> (1)...(60)
<223> Alpha amylase signal peptide

<400> 58
atggttgctt ggtggtcctt gttcttgtac ggattgcaag ttgctgctcc agctttggct 60
gagatcgttt tgacacagtc cccagctact ttgtctttgt ccccaggtga aagagctaca 120
ttgtcctgta gagcttcctc ttccgtttcc tacatccact ggtatcaaca aaagccagga 180
caggctccaa gattgttgat ctacgctact tccaacttgg cttccggtat tccagctaga 240
ttctctggtt ctggttccgg tactgacttc actttgacta tctcttcctt ggaaccagag 300
gacttcgctg tttactactg tcaacagtgg acttctaacc caccaacttt cggacaaggt 360
actaaggttg agatcaagcg tacggttgct gctccttccg ttttcatttt cccaccatcc 420
gacgaacaat tgaagtctgg taccgcttcc gttgtttgtt tgttgaacaa cttctaccca 480
cgtgaggcta aggttcagtg gaaggttgac aacgctttgc aatccggtaa ctcccaagaa 540
tccgttactg agcaggattc taaggattcc acttactcat tgtcctccac tttgactttg 600
tccaaggctg attacgagaa gcacaaggtt tacgcatgcg aggttacaca tcagggtttg 660
tcctccccag ttactaagtc cttcaacaga ggagagtgtt aa                    702

<210> 59
<211> 1602
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-Her2 full length HC with GR1 ORF and Pre-pro
      alpha- mating factor signal peptide
      (ScalphaMTprepro)

<220> 
<221> sig_peptide    
<222> (1)...(57)
<223> Signal peptide

<220> 
<221> misc_feature   
<222> (1483)...(1602)
<223> GR1 coiled coil

<400> 59
atgagattcc catccatctt cactgctgtt ttgttcgctg cttcttctgc tttggctgag 60
gttcagttgg ttgaatctgg aggaggattg gttcaacctg gtggttcttt gagattgtcc 120
tgtgctgctt ccggtttcaa catcaaggac acttacatcc actgggttag acaagctcca 180
ggaaagggat tggagtgggt tgctagaatc tacccaacta acggttacac aagatacgct 240
gactccgtta agggaagatt cactatctct gctgacactt ccaagaacac tgcttacttg 300
cagatgaact ccttgagagc tgaggatact gctgtttact actgttccag atggggtggt 360
gatggtttct acgctatgga ctactggggt caaggaactt tggttactgt ttcctccgct 420
tctactaagg gaccatctgt tttcccattg gctccatctt ctaagtctac ttccggtggt 480
actgctgctt tgggatgttt ggttaaagac tacttcccag agccagttac tgtttcttgg 540
aactccggtg ctttgacttc tggtgttcac actttcccag ctgttttgca atcttccggt 600
ttgtactctt tgtcctccgt tgttactgtt ccatcctctt ccttgggtac tcagacttac 660
atctgtaacg ttaaccacaa gccatccaac actaaggttg acaagaaggt tgagccaaag 720
tcctgtgaca agactcatac ttgtccacca tgtccagctc cagaattgtt gggtggtcct 780
tccgtttttt tgttcccacc aaagccaaag gacactttga tgatctccag aactccagag 840
gttacatgtg ttgttgttga cgtttctcac gaggacccag aggttaagtt caactggtac 900
gttgacggtg ttgaagttca caacgctaag actaagccaa gagaggagca gtacaactcc 960
acttacagag ttgtttccgt tttgactgtt ttgcaccagg attggttgaa cggaaaggag 1020
tacaagtgta aggtttccaa caaggctttg ccagctccaa tcgaaaagac tatctccaag 1080
gctaagggtc aaccaagaga gccacaggtt tacactttgc caccatccag agatgagttg 1140
actaagaacc aggtttcctt gacttgtttg gttaagggat tctacccatc cgacattgct 1200
gttgaatggg agtctaacgg tcaaccagag aacaactaca agactactcc acctgttttg 1260
gactctgacg gttccttttt cttgtactcc aagttgactg ttgacaagtc cagatggcaa 1320
cagggtaacg ttttctcctg ttccgttatg catgaggctt tgcacaacca ctacactcaa 1380
aagtccttgt ctttgtcccc tggtaaggcg gccgcttatc catatgatgt tccagactac 1440
gctggaggtc atcatcatca ccaccatcac catcatggtg gtgaagagaa gtccagattg 1500
ttggagaaag agaacagaga gttggagaag atcatcgctg agaaagaaga gagagtttcc 1560
gagttgagac accaattgca atccgttggt ggttgttaat ag                    1602

<210> 60
<211> 1619
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-Her2 full length HC with Pre-pro alpha-
      mating factor signal peptide (ScalphaMTprepro) and
      GR1 with single stop codon between

<220> 
<221> sig_peptide    
<222> (1)...(57)
<223> signal peptide

<220> 
<221> terminator     
<222> (1408)...(1410)
<223> stop codon

<220> 
<221> misc_feature   
<222> (1486)...(1619)
<223> GR1 coiled coil

<400> 60
atgagattcc catccatctt cactgctgtt ttgttcgctg cttcttctgc tttggctgag 60
gttcagttgg ttgaatctgg aggaggattg gttcaacctg gtggttcttt gagattgtcc 120
tgtgctgctt ccggtttcaa catcaaggac acttacatcc actgggttag acaagctcca 180
ggaaagggat tggagtgggt tgctagaatc tacccaacta acggttacac aagatacgct 240
gactccgtta agggaagatt cactatctct gctgacactt ccaagaacac tgcttacttg 300
cagatgaact ccttgagagc tgaggatact gctgtttact actgttccag atggggtggt 360
gatggtttct acgctatgga ctactggggt caaggaactt tggttactgt ttcctccgct 420
tctactaagg gaccatctgt tttcccattg gctccatctt ctaagtctac ttccggtggt 480
actgctgctt tgggatgttt ggttaaagac tacttcccag agccagttac tgtttcttgg 540
aactccggtg ctttgacttc tggtgttcac actttcccag ctgttttgca atcttccggt 600
ttgtactctt tgtcctccgt tgttactgtt ccatcctctt ccttgggtac tcagacttac 660
atctgtaacg ttaaccacaa gccatccaac actaaggttg acaagaaggt tgagccaaag 720
tcctgtgaca agactcatac ttgtccacca tgtccagctc cagaattgtt gggtggtcct 780
tccgtttttt tgttcccacc aaagccaaag gacactttga tgatctccag aactccagag 840
gttacatgtg ttgttgttga cgtttctcac gaggacccag aggttaagtt caactggtac 900
gttgacggtg ttgaagttca caacgctaag actaagccaa gagaggagca gtacaactcc 960
acttacagag ttgtttccgt tttgactgtt ttgcaccagg attggttgaa cggaaaggag 1020
tacaagtgta aggtttccaa caaggctttg ccagctccaa tcgaaaagac tatctccaag 1080
gctaagggtc aaccaagaga gccacaggtt tacactttgc caccatccag agatgagttg 1140
actaagaacc aggtttcctt gacttgtttg gttaagggat tctacccatc cgacattgct 1200
gttgaatggg agtctaacgg tcaaccagag aacaactaca agactactcc acctgttttg 1260
gactctgacg gttccttttt cttgtactcc aagttgactg ttgacaagtc cagatggcaa 1320
cagggtaacg ttttctcctg ttccgttatg catgaggctt tgcacaacca ctacactcaa 1380
aagtccttgt ctttgtcccc tggtaagtag gcggccgctt atccatatga tgttccagac 1440
tacgctggag gtcatcatca tcaccaccat caccatcatg gtggtgaaga gaagtccaga 1500
ttgttggaga aagagaacag agagttggag aagatcatcg ctgagaaaga agagagagtt 1560
tccgagttga gacaccaatt gcaatccgtt ggtggttgtt aatagggccg gccatttaa  1619

<210> 61
<211> 1611
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-CD20 C2B8 full length HC with Alpha amylase
      signal peptide (from Aspergillus niger
      alpha-amylase) (DNA) and GR1 with single stop
      codon between

<220> 
<221> sig_peptide    
<222> (1)...(60)
<223> Signal peptide

<220> 
<221> terminator     
<222> (1414)...(1416)
<223> stop codon

<220> 
<221> misc_feature   
<222> (1491)...(1611)
<223> GR1 coiled coil

<400> 61
atggttgctt ggtggtcttt gttcttgtac ggattgcaag ttgctgctcc agctttggct 60
caagttcagc tgcaacaacc aggtgctgaa ttggttaagc ctggtgcttc tgttaagatg 120
tcttgtaagg cttctggtta cactttcact tcctacaaca tgcactgggt taagcaaact 180
ccaggtagag gattggaatg gattggtgct atctacccag gtaacggtga cacttcttat 240
aaccaaaagt tcaagggaaa ggctactttg actgctgaca aatcttcttc tactgcttac 300
atgcaattgt cctccttgac ttctgaagat tctgctgttt actactgtgc tagatccact 360
tactacggtg gtgactggta ctttaatgtt tggggtgctg gtactactgt tactgtctcg 420
agtgcttcta ctaagggacc atctgttttc ccattggctc catcttctaa gtctacttcc 480
ggtggtaccg ctgctttggg atgtttggtt aaagactact tcccagagcc agttactgtt 540
tcttggaact ccggtgcttt gacttctggt gttcacactt tcccagctgt tttgcaatct 600
tccggtttgt actctttgtc ctccgttgtt actgttccat cctcttcctt gggtactcag 660
acttacatct gtaacgttaa ccacaagcca tccaacacta aggttgacaa gaaggttgag 720
ccaaagtcct gtgacaagac tcatacttgt ccaccatgtc cagctccaga attgttgggt 780
ggtccttccg tttttttgtt cccaccaaag ccaaaggaca ctttgatgat ctccagaact 840
ccagaggtta catgtgttgt tgttgacgtt tctcacgagg acccagaggt taagttcaac 900
tggtacgttg acggtgttga agttcacaac gctaagacta agccaagaga ggagcagtac 960
aactccactt acagagttgt ttccgttttg actgttttgc accaggattg gttgaacgga 1020
aaggagtaca agtgtaaggt ttccaacaag gctttgccag ctccaatcga aaagactatc 1080
tccaaggcta agggtcaacc aagagagcca caggtttaca ctttgccacc atccagagat 1140
gagttgacta agaaccaggt ttccttgact tgtttggtta agggattcta cccatccgac 1200
attgctgttg aatgggagtc taacggtcaa ccagagaaca actacaagac tactccacct 1260
gttttggact ctgacggttc ctttttcttg tactccaagt tgactgttga caagtccaga 1320
tggcaacagg gtaacgtttt ctcctgttcc gttatgcatg aggctttgca caaccactac 1380
actcaaaagt ccttgtcttt gtcccctggt aagtaggcgg ccgcttatcc atatgatgtt 1440
ccagactacg ctggaggtca tcatcatcac caccatcacc atcatggtgg tgaagagaag 1500
tccagattgt tggagaaaga gaacagagag ttggagaaga tcatcgctga gaaagaagag 1560
agagtttccg agttgagaca ccaattgcaa tccgttggtg gttgttaata g          1611

<210> 62
<211> 1617
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-CD20 Genmab full length HC with with Alpha
      amylase signal peptide (from Aspergillus niger
      alpha-amylase) and GR1 with single stop codon
      between

<220> 
<221> sig_peptide    
<222> (1)...(60)
<223> Signal peptide

<220> 
<221> terminator     
<222> (1420)...(142)
<223> Stop codon

<220> 
<221> misc_feature   
<222> (1498)...(1617)
<223> GR1 coiled coil

<400> 62
atggttgctt ggtggtcctt gttcttgtac ggattgcaag ttgctgctcc agctttggct 60
gctgttcagc tggttgaatc tggtggtgga ttggttcaac ctggtagatc cttgagattg 120
tcctgtgctg cttccggttt tactttcggt gactacacta tgcactgggt tagacaagct 180
ccaggaaagg gattggaatg ggtttccggt atttcttgga actccggttc cattggttac 240
gctgattccg ttaagggaag attcactatc tccagagaca acgctaagaa ctccttgtac 300
ttgcagatga actccttgag agctgaggat actgctttgt actactgtac taaggacaac 360
caatacggtt ctggttccac ttacggattg ggagtttggg gacagggaac tttggttact 420
gtctcgagtg cttctactaa gggaccatcc gtttttccat tggctccatc ctctaagtct 480
acttccggtg gtaccgctgc tttgggatgt ttggttaaag actacttccc agagccagtt 540
actgtttctt ggaactccgg tgctttgact tctggtgttc acactttccc agctgttttg 600
caatcttccg gtttgtactc tttgtcctcc gttgttactg ttccatcctc ttccttgggt 660
actcagactt acatctgtaa cgttaaccac aagccatcca acactaaggt tgacaagaag 720
gttgagccaa agtcctgtga caagactcat acttgtccac catgtccagc tccagaattg 780
ttgggtggtc cttccgtttt tttgttccca ccaaagccaa aggacacttt gatgatctcc 840
agaactccag aggttacatg tgttgttgtt gacgtttctc acgaggaccc agaggttaag 900
ttcaactggt acgttgacgg tgttgaagtt cacaacgcta agactaagcc aagagaggag 960
cagtacaact ccacttacag agttgtttcc gttttgactg ttttgcacca ggattggttg 1020
aacggaaagg agtacaagtg taaggtttcc aacaaggctt tgccagctcc aatcgaaaag 1080
actatctcca aggctaaggg tcaaccaaga gagccacagg tttacacttt gccaccatcc 1140
agagatgagt tgactaagaa ccaggtttcc ttgacttgtt tggttaaggg attctaccca 1200
tccgacattg ctgttgaatg ggagtctaac ggtcaaccag agaacaacta caagactact 1260
ccacctgttt tggactctga cggttccttt ttcttgtact ccaagttgac tgttgacaag 1320
tccagatggc aacagggtaa cgttttctcc tgttccgtta tgcatgaggc tttgcacaac 1380
cactacactc aaaagtcctt gtctttgtcc cctggtaagt aggcggccgc ttatccatat 1440
gatgttccag actacgctgg aggtcatcat catcaccacc atcaccatca tggtggtgaa 1500
gagaagtcca gattgttgga gaaagagaac agagagttgg agaagatcat cgctgagaaa 1560
gaagagagag tttccgagtt gagacaccaa ttgcaatccg ttggtggttg ttaatag    1617

<210> 63
<211> 705
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-CD20 Genmab LC with with Alpha amylase signal
      peptide (from Aspergillus niger  alpha-amylase)

<220> 
<221> sig_peptide    
<222> (1)...(60)
<223> Signal peptide

<400> 63
atggttgctt ggtggtcctt gttcttgtac ggattgcaag ttgctgctcc agctttggct 60
gagatcgttt tgacacagtc cccagctact ttgtctttgt ccccaggtga aagagctaca 120
ttgtcctgta gagcttccca atctgtttcc tcctacttgg cttggtatca acaaaagcca 180
ggacaggctc caagattgtt gatctacgac gcttccaata gagctactgg tatcccagct 240
agattctctg gttctggttc cggtactgac ttcactttga ctatctcttc cttggaacca 300
gaggacttcg ctgtttacta ctgtcagcag agatccaatt ggccattgac tttcggtggt 360
ggtactaagg ttgagatcaa gcgtacggtt gctgctcctt ccgttttcat tttcccacca 420
tccgacgaac aattgaagtc tggtaccgct tccgttgttt gtttgttgaa caacttctac 480
ccacgtgagg ctaaggttca gtggaaggtt gacaacgctt tgcaatccgg taactcccaa 540
gaatccgtta ctgagcagga ttctaaggat tccacttact cattgtcctc cactttgact 600
ttgtccaagg ctgattacga gaagcacaag gtttacgcat gcgaggttac acatcagggt 660
ttgtcctccc cagttactaa gtccttcaac agaggagagt gttaa                 705

<210> 64
<211> 1611
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-CD20 full length HC with Alpha amylase signal
      peptide (from Aspergillus niger  alpha-amylase)
      and GR1 and stop codon between

<220> 
<221> sig_peptide    
<222> (1)...(60)
<223> Signal peptide

<220> 
<221> terminator     
<222> (1414)...(1416)
<223> Stop codon

<220> 
<221> misc_feature   
<222> (142)...(1611)
<223> GR1 coiled coil

<400> 64
atggttgctt ggtggtcctt gttcttgtac ggattgcaag ttgctgctcc agctttggct 60
caagttcagc tggttcaatc tggtgctgag gttaagaagc ctggttcctc cgttaaggtt 120
tcctgtaagg cttccggtta cactttcact tcctacaaca tgcactgggt tagacaagct 180
ccaggtcaag gattggaatg gatgggtgct atctacccag gtaacggtga cacttcttac 240
aaccagaagt tcaagggtag agttactatc actgctgacg aatccacttc cactgcttac 300
atggaattgt cctcattgag atccgaggac actgctgttt actactgtgc tagatccact 360
tactacggtg gtgactggta ctttaatgtt tggggacagg gaactttggt tactgtctcg 420
agtgcttcta ctaagggacc atccgttttt ccattggctc catcctctaa gtctacttcc 480
ggtggtaccg ctgctttggg atgtttggtt aaagactact tcccagagcc agttactgtt 540
tcttggaact ccggtgcttt gacttctggt gttcacactt tcccagctgt tttgcaatct 600
tccggtttgt actctttgtc ctccgttgtt actgttccat cctcttcctt gggtactcag 660
acttacatct gtaacgttaa ccacaagcca tccaacacta aggttgacaa gaaggttgag 720
ccaaagtcct gtgacaagac tcatacttgt ccaccatgtc cagctccaga attgttgggt 780
ggtccttccg tttttttgtt cccaccaaag ccaaaggaca ctttgatgat ctccagaact 840
ccagaggtta catgtgttgt tgttgacgtt tctcacgagg acccagaggt taagttcaac 900
tggtacgttg acggtgttga agttcacaac gctaagacta agccaagaga ggagcagtac 960
aactccactt acagagttgt ttccgttttg actgttttgc accaggattg gttgaacgga 1020
aaggagtaca agtgtaaggt ttccaacaag gctttgccag ctccaatcga aaagactatc 1080
tccaaggcta agggtcaacc aagagagcca caggtttaca ctttgccacc atccagagat 1140
gagttgacta agaaccaggt ttccttgact tgtttggtta agggattcta cccatccgac 1200
attgctgttg aatgggagtc taacggtcaa ccagagaaca actacaagac tactccacct 1260
gttttggact ctgacggttc ctttttcttg tactccaagt tgactgttga caagtccaga 1320
tggcaacagg gtaacgtttt ctcctgttcc gttatgcatg aggctttgca caaccactac 1380
actcaaaagt ccttgtcttt gtcccctggt aagtaggcgg ccgcttatcc atatgatgtt 1440
ccagactacg ctggaggtca tcatcatcac caccatcacc atcatggtgg tgaagagaag 1500
tccagattgt tggagaaaga gaacagagag ttggagaaga tcatcgctga gaaagaagag 1560
agagtttccg agttgagaca ccaattgcaa tccgttggtg gttgttaata g          1611

<210> 65
<211> 702
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-CD20 LC with Alpha amylase signal peptide
      (from Aspergillus niger  alpha-amylase)

<220> 
<221> sig_peptide    
<222> (1)...(60)
<223> Signal peptide

<400> 65
atggttgctt ggtggtcctt gttcttgtac ggattgcaag ttgctgctcc agctttggct 60
gagatcgttt tgacacagtc cccagctact ttgtctttgt ccccaggtga aagagctaca 120
ttgtcctgta gagcttcctc ttccgtttcc tacatccact ggtatcaaca aaagccagga 180
caggctccaa gattgttgat ctacgctact tccaacttgg cttccggtat tccagctaga 240
ttctctggtt ctggttccgg tactgacttc actttgacta tctcttcctt ggaaccagag 300
gacttcgctg tttactactg tcaacagtgg acttctaacc caccaacttt cggacaaggt 360
actaaggttg agatcaagcg tacggttgct gctccttccg ttttcatttt cccaccatcc 420
gacgaacaat tgaagtctgg taccgcttcc gttgtttgtt tgttgaacaa cttctaccca 480
cgtgaggcta aggttcagtg gaaggttgac aacgctttgc aatccggtaa ctcccaagaa 540
tccgttactg agcaggattc taaggattcc acttactcat tgtcctccac tttgactttg 600
tccaaggctg attacgagaa gcacaaggtt tacgcatgcg aggttacaca tcagggtttg 660
tcctccccag ttactaagtc cttcaacaga ggagagtgtt aa                    702

<210> 66
<211> 993
<212> DNA
<213> Artificial Sequence

<220> 
<223>  1D05 Heavy chain with Saccharomyces cerevisiae
      mating factor pre-signal peptide and GR1

<220> 
<221> sig_peptide    
<222> (1)...(57)
<223> Signal peptide

<220> 
<221> misc_feature   
<222> (874)...(993)
<223> GR1 coiled coil

<400> 66
atgagattcc catccatctt cactgctgtt ttgttcgctg cttcttccgc tttggctcag 60
gttcaattgg ttcaatccgg tgctgaagtt aagaagcctg gttcctccgt taaggtttcc 120
tgtaaggctt ctggtggtac ttttaactcc cacgctatct cttgggttag acaagctcca 180
ggtcaaggat tggaatggat gggtggtatc aacccaattt tgggtatcgc taactacgct 240
caaaagttcc agggtagagt tactattact gctgacgaat ccacttccac tgcttacatg 300
gaattgtcct cattgagatc cgaggacact gctgtttact actgtgctag acactacgag 360
atccagatcg gtagatacgg aatgaacgtt tactacttga tgtacagatt cgcttcttgg 420
ggacagggaa ctttggttac tgtctcgagt gcttctacta aggggccctc tgtttttcca 480
ttggctccat gttctagatc cacttccgaa tccactgctg ctttgggatg tttggttaag 540
gactacttcc cagagccagt tactgtttct tggaactccg gtgctttgac ttctggtgtt 600
cacactttcc cagctgtttt gcaatcttcc ggtttgtact ccttgtcctc cgttgttact 660
gttacttcct ccaacttcgg tactcagact tacacttgta acgttgacca caagccatcc 720
aacactaagg ttgacaagac tgttgagaga aagggtggtg gtggtagtgg aggtggtgga 780
agtggtggcg gtggttctgc ggccgcttat ccatatgatg ttccagacta cgctggaggt 840
catcatcatc accaccatca ccatcatggt ggtgaagaga agtccagatt gttggagaaa 900
gagaacagag agttggagaa gatcatcgct gagaaagaag agagagtttc cgagttgaga 960
caccaattgc aatccgttgg tggttgttaa tag                              993

<210> 67
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1D05 Heavy chain with Saccharomyces cerevisiae
      mating factor pre-signal peptide

<220> 
<221> SIGNAL         
<222> (1)...(19)
<223> Signal peptide

<400> 67
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser
                -15                 -10                 -5      
Ala Leu Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
             1               5                  10              
Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe
    15                  20                  25                  
Asn Ser His Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
30                  35                  40                  45  
Glu Trp Met Gly Gly Ile Asn Pro Ile Leu Gly Ile Ala Asn Tyr Ala
                50                  55                  60      
Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser
            65                  70                  75          
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val
        80                  85                  90              
Tyr Tyr Cys Ala Arg His Tyr Glu Ile Gln Ile Gly Arg Tyr Gly Met
    95                  100                 105                 
Asn Val Tyr Tyr Leu Met Tyr Arg Phe Ala Ser Trp Gly Gln Gly Thr
110                 115                 120                 125 
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
                130                 135                 140     
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly
            145                 150                 155         
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
        160                 165                 170             
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
    175                 180                 185                 
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Thr Ser Ser
190                 195                 200                 205 
Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser
                210                 215                 220     
Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys
            225                 230         


<210> 68
<211> 702
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1D05 light chain with Saccharomyces cerevisiae
      mating factor pre-signal peptide

<220> 
<221> sig_peptide    
<222> (1)...(57)
<223> Signal peptide

<400> 68
atgagattcc catccatctt cactgctgtt ttgttcgctg cttcttctgc tttggctgac 60
atccaaatga cacaatcccc atcttccttg tctgcttccg ttggtgacag agttactatc 120
acttgtagag cttcccaagg tatcagatcc gctttgaact ggtatcaaca gaagccagga 180
aaggctccaa agttgttgat ctacaacggt tccactttgc aatctggtgt tccatctaga 240
ttctctggtt ccggttctgg tactgacttc actttgacta tctcttcctt gcaaccagag 300
gacttcgctg tttactactg tcaacagttc gatggtgacc caacttttgg acagggtact 360
aaggttgaga tcaagagaac tgttgctgct ccatccgttt tcattttccc accatccgac 420
gaacaattga agtctggtac cgcttccgtt gtttgtttgt tgaacaactt ctacccacgt 480
gaggctaagg ttcagtggaa ggttgacaac gctttgcaat ccggtaactc ccaagaatcc 540
gttactgagc aggattctaa ggattccact tactcattgt cctccacttt gactttgtcc 600
aaggctgatt acgagaagca caaggtttac gcttgcgagg ttacacatca gggtttgtcc 660
tccccagtta ctaagtcctt caacagagga gagtgttaat ag                    702

<210> 69
<211> 232
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1D05 LC with Saccharomyces cerevisiae mating
      factor pre-signal peptide

<220> 
<221> SIGNAL         
<222> (1)...(19)
<223> Signal peptide

<400> 69
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser
                -15                 -10                 -5      
Ala Leu Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
             1               5                  10              
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile
    15                  20                  25                  
Arg Ser Ala Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
30                  35                  40                  45  
Leu Leu Ile Tyr Asn Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg
                50                  55                  60      
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
            65                  70                  75          
Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asp Gly
        80                  85                  90              
Asp Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val
    95                  100                 105                 
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
110                 115                 120                 125 
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
                130                 135                 140     
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
            145                 150                 155         
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
        160                 165                 170             
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
    175                 180                 185                 
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
190                 195                 200                 205 
Lys Ser Phe Asn Arg Gly Glu Cys
                210             


<210> 70
<211> 945
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1H23 heavy chain with Aspergillus amylase signal
      sequence and GR1

<220> 
<221> sig_peptide    
<222> (1)...(60)
<223> Signal peptide

<220> 
<221> misc_feature   
<222> (826)...(945)
<223> GR1 coiled coil

<400> 70
atggttgctt ggtggtcctt gttcttgtac ggattgcaag ttgctgctcc agctttggct 60
caagttcagt tggttgaatc cggtggtgga ttggttcaac ctggtggttc tttgagattg 120
tcctgtgctg cttccggttt tactttctcc gactactaca tgcactgggt tagacaagca 180
cctggaaagg gattggaatg ggtttccaac atttctggtt ccggttccac tacttactac 240
gctgattccg ttaagggaag attcactatc tccagagaca actccaagaa cactttgtac 300
ttgcagatga actccttgag agctgaggat actgctgttt actactgtgc tagaggaatg 360
tttgacttct ggggacaggg aactttggtt actgtctcga gtgcttctac taaggggccc 420
tctgtttttc cattggctcc atgttctaga tccacttccg aatccactgc tgctttggga 480
tgtttggtta aggactactt cccagagcca gttactgttt cttggaactc cggtgctttg 540
acttctggtg ttcacacttt cccagctgtt ttgcaatctt ccggtttgta ctccttgtcc 600
tccgttgtta ctgttacttc ctccaacttc ggtactcaga cttacacttg taacgttgac 660
cacaagccat ccaacactaa ggttgacaag actgttgaga gaaagggtgg tggtggtagt 720
ggaggtggtg gaagtggtgg cggtggttct gcggccgctt atccatatga tgttccagac 780
tacgctggag gtcatcatca tcaccaccat caccatcatg gtggtgaaga gaagtccaga 840
ttgttggaga aagagaacag agagttggag aagatcatcg ctgagaaaga agagagagtt 900
tccgagttga gacaccaatt gcaatccgtt ggtggttgtt aatag                 945

<210> 71
<211> 234
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1H23 heavy chain with Aspergillus amylase signal
      sequence

<220> 
<221> SIGNAL         
<222> (1)...(19)
<223> Signal peptide

<400> 71
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser
                -15                 -10                 -5      
Ala Leu Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
             1               5                  10              
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
    15                  20                  25                  
Ser Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
30                  35                  40                  45  
Glu Trp Val Ser Asn Ile Ser Gly Ser Gly Ser Thr Thr Tyr Tyr Ala
                50                  55                  60      
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
            65                  70                  75          
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
        80                  85                  90              
Tyr Tyr Cys Ala Arg Gly Met Phe Asp Phe Trp Gly Gln Gly Thr Leu
    95                  100                 105                 
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu
110                 115                 120                 125 
Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys
                130                 135                 140     
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
            145                 150                 155         
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser
        160                 165                 170             
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn
    175                 180                 185                 
Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn
190                 195                 200                 205 
Thr Lys Val Asp Lys Thr Val Glu Arg Lys
                210                 215 


<210> 72
<211> 717
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1H23 light chain with Aspergillus amylase signal
      sequence

<220> 
<221> sig_peptide    
<222> (1)...(60)
<223> Signal peptide

<400> 72
atggttgctt ggtggtcctt gttcttgtac ggattgcaag ttgctgctcc agctttggct 60
gacatcgttt tgacacagtc cccagctact ttgtctttgt ccccaggtga aagagctaca 120
ttgtcctgta gagcttccca atccgttaac tccaactact tggcttggta tcaacaaaag 180
ccaggacagg ctccaagatt gttgatctac ggtgcttctt ctagagctac tggtgttcca 240
gctagattct ctggttctgg ttccggtact gacttcactt tgactatctc ttccttggaa 300
ccagaggact tcgctgttta ctactgtcaa cagtggggtg acgttccaat tactttcgga 360
cagggtacta aggttgagat caagagaact gttgctgctc cttccgtttt cattttccca 420
ccatccgacg aacaattgaa gtctggtacc ggtaccgctt ccgttgtttg tttgttgaac 480
aacttctacc cacgtgaggc taaggttcag tggaaggttg acaacgcttt gcaatccggt 540
aactcccaag aatccgttac tgagcaggat tctaaggatt ccacttactc attgtcctcc 600
actttgactt tgtccaaggc tgattacgag aagcacaagg tttacgcttg cgaggttaca 660
catcagggtt tgtcctcccc agttactaag tccttcaaca gaggagagtg ttaatag    717

<210> 73
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1H23 light chain

<220> 
<221> SIGNAL         
<222> (1)...(20)
<223> Signal peptide

<400> 73
Met Val Ala Trp Trp Ser Leu Phe Leu Tyr Gly Leu Gln Val Ala Ala
-20                 -15                 -10                 -5  
Pro Ala Leu Ala Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
                 1               5                  10          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser
        15                  20                  25              
Val Asn Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala
    30                  35                  40                  
Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro
45                  50                  55                  60  
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                65                  70                  75      
Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp
            80                  85                  90          
Gly Asp Val Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
        95                  100                 105             
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
    110                 115                 120                 
Gln Leu Lys Ser Gly Thr Gly Thr Ala Ser Val Val Cys Leu Leu Asn
125                 130                 135                 140 
Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                145                 150                 155     
Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys
            160                 165                 170         
Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp
        175                 180                 185             
Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu
    190                 195                 200                 
Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
205                 210                 215         


<210> 74
<211> 662
<212> PRT
<213> Artificial Sequence

<220> 
<223> PCSK9

<400> 74
Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg
 1               5                  10                  15      
Ser Glu Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala
            20                  25                  30          
Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr
        35                  40                  45              
Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr
    50                  55                  60                  
Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys
65                  70                  75                  80  
Ile Leu His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met
                85                  90                  95      
Ser Gly Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr
            100                 105                 110         
Ile Glu Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu
        115                 120                 125             
Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro
    130                 135                 140                 
Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln
145                 150                 155                 160 
Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu
                165                 170                 175     
Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys
            180                 185                 190         
Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp
        195                 200                 205             
Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn
    210                 215                 220                 
Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe
225                 230                 235                 240 
Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu
                245                 250                 255     
Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln
            260                 265                 270         
Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe
        275                 280                 285             
Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile
    290                 295                 300                 
Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr
305                 310                 315                 320 
Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu
                325                 330                 335     
Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln
            340                 345                 350         
Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met
        355                 360                 365             
Met Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg
    370                 375                 380                 
Leu Ile His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro
385                 390                 395                 400 
Glu Asp Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro
                405                 410                 415     
Ser Thr His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser
            420                 425                 430         
Ala His Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala
        435                 440                 445             
Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys
    450                 455                 460                 
Arg Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg
465                 470                 475                 480 
Ala His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys
                485                 490                 495     
Cys Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala
            500                 505                 510         
Glu Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val
        515                 520                 525             
Leu Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His
    530                 535                 540                 
Lys Pro Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly
545                 550                 555                 560 
His Arg Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu
                565                 570                 575     
Glu Cys Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val
            580                 585                 590         
Thr Val Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu
        595                 600                 605             
Pro Gly Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys
    610                 615                 620                 
Val Val Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu
625                 630                 635                 640 
Ala Val Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln
                645                 650                 655     
Ala Ser Gln Glu Leu Gln
            660         

